title: [Human allogeneic cultured epidermis: medico-legal considerations].
abstract: The possibility of cultivating in vitro human kerathinocytes has opened new prospectives in the surgical treatment of major burns and, generally, in patients with extensive skin loss (degloving, etc.). Epidermidal sheets, obtained in vitro, have been used initially, successfully, as autografts. Later, their peculiar immunological characteristic (absence of Langerhans cells expressing class II MHC antigens and inability of evocating omograft rejection) has allowed it's use as allograft without the need of resorting to treatment with immunosuppressive drugs. Medico-legal problems raised by the use of human epidermys cultivated as allograft are described hereafter.
authors.affiliation: Cattedra di Medicina Legale e delle Assicurazioni, Va, Università degli Studi di Roma La Sapienza.
authors.forename: M
authors.initials: M
authors.lastname: Angelini Rota
authors.forename: E
authors.initials: E
authors.lastname: Mezzetti
authors.forename: G
authors.initials: G
authors.lastname: Sabatini
authors.forename: M
authors.initials: M
authors.lastname: Monti
mesh_terms: D002056:Burns / Q000601:surgery; D002478:Cells, Cultured; D006801:Humans; D007558:Italy; D015603:Keratinocytes; D007801:Langerhans Cells; D016038:Skin Transplantation / Q000331:legislation & jurisprudence*; D014019:Tissue Donors; D014184:Transplantation, Homologous
vernacular_title: Epidermide umana coltivata allogenica: considerazioni medico-legali.