[Identification of effective region of the pons in response to inaperisone which facilitates urine storage].
To identify the effective region of the pons in response to inaperisone which facilitates urine storage, inaperisone (100 mM, 0.2 microliters) was injected into the nucleus locus coeruleus alpha (LCa, the pontine micturition center), the nucleus locus subcoeruleus (LSC, the pontine urine storage center) and the nucleus reticularis pontis oralis (PoO, micturition inhibitory region) of the decerebrate cats. On reflex micturition, inaperisone injection into the LSC decreased voiding volume, and increased residual volume and bladder capacity, significantly. However, there was no difference in the maximum bladder pressure before and after inaperisone injection into the LSC. Inaperisone injection into the LCa or the PoO had no influence on reflex micturition. These results suggest that effective region of the pons in response to inaperisone is the LSC, and that inaperisone facilitates the urine storage neural mechanism in the LSC.
Sugaya
K
K
Department of Urology, Akita University School of Medicine.
Nishizawa
O
O
Noto
H
H
Tsukada
T
T
Kohama
T
T
Shimoda
N
N
Harada
T
T
Tsuchida
S
S
D000818:Animals; D002415:Cats; D004576:Electromyography; D005260:Female; D008297:Male; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D011149:Pons / Q000187:drug effects* / Q000502:physiology; D011427:Propiophenones / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects* / Q000502:physiology; D001743:Urinary Bladder / Q000502:physiology; D014554:Urination / Q000187:drug effects*
D009125:Muscle Relaxants, Central; D011427:Propiophenones; C052425:inaperisone