A cytopathic effect of Trichomonas vaginalis probably mediated by a mannose/N-acetyl-glucosamine binding lectin.
The pathogenic effect of a highly pathogenic strain of Trichomonas vaginalis on McCoy cell monolayers was investigated. Specific inhibition of the cytopathic effect by monosaccharides, such as N-acetyl-glucosamine (GlcNAc) and mannose (Man), was observed. Our preliminary results suggest that the pathogenicity of T. vaginalis depends on a lectin specifically sensitive to GlcNAc and to a lesser extent to Man. Although N-acetyl-mannosamine was found to be the most efficient inhibitor, this effect seems to be unrelated to the natural biological behaviour of the infested host.
Roussel
F
F
Laboratoire d'Histologie, Hôpital Charles Nicolle, Rouen, France.
De Carli
G
G
Brasseur
P
P
D000117:Acetylglucosamine / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D037102:Lectins / Q000378:metabolism*; D008358:Mannose / Q000378:metabolism*; D014246:Trichomonas vaginalis / Q000472:pathogenicity*
D037102:Lectins; D008358:Mannose; D000117:Acetylglucosamine