Pharmacokinetics of alpha-dihydroergokryptine in monkeys after oral administration.
The pharmacokinetic profile of a single dose (6 mg/kg) of alpha-dihydroergokryptine (alpha-DHEK) was established after oral administration in monkeys using a radio-immunoassay technique for non-metabolized drug. alpha-DHEK showed a plasma profile according to an open three-compartment pharmacokinetic model with a long half-life (mean = 5.787 h). The disposition of alpha-DHEK involves a fast absorption, a slow distribution phase and a slow elimination phase. alpha-DHEK showed an high total clearance and distribution volume; the drug is largely metabolized, as concluded from the very low urinary excretion.
Grognet
J M
JM
Service of Pharmacology and Immunology, DRIPP, Gif-sur-Yvette, France.
Istin
M
M
Zanotti
A
A
Mailland
F
F
Coppi
G
G
D000284:Administration, Oral; D000818:Animals; D004088:Dihydroergotoxine / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D008252:Macaca fascicularis; D008297:Male
D004088:Dihydroergotoxine