Various hippocampal lesions induced by multi-fractional ibotenic acid injections and amygdala kindling in rats.
Hippocampal degenerative lesions were made bilaterally by means of multiple ibotenic acid injections and development of amygdala kindling was studied. In groups with lesions in either bilateral dorsal or ventral hippocampus, stimulations required for kindling were almost the same as those of controls. In the group with lesion of the entire hippocampus, kindling development was remarkably slow especially in the early stage of the kindling process. However, kindling effect was finally established in all groups.
Tanaka
T
T
Department of Neurosurgery, Asahikawa Medical College, Japan.
Kondo
S
S
Hori
T
T
Tanaka
S
S
Yonemasu
Y
Y
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004569:Electroencephalography; D006624:Hippocampus / Q000033:anatomy & histology / Q000187:drug effects*; D007051:Ibotenic Acid / Q000008:administration & dosage / Q000633:toxicity*; D007267:Injections; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques
D007051:Ibotenic Acid