[The mechanisms of neutrophilic oxygen damage in ischemic and reperfusion lesions. Pharmacological manipulations].
This work studies the ischemic/reperfusion injury (I/R) in relationship to the production of free radicals from activated neutrophils. It is well known, that biochemical and physiopathological alterations participate in the tissue lesion produced by the interaction oxygen/leukocyte. Pharmacological manipulations, oriented to eliminate the harmful effect of the free radicals, remain as the most significant event in the management of the I/R injury. Compounds such as allopurinol, adenosine, naloxone, corticosteroids, methylurea, and others, have demonstrated a protective effect during the I/R injury. Although, the mechanism of action of these compounds is unknown, it is possible that the free radical scavenging effect, could be the most important protective mechanism. The better understanding of the I/R injury would allow for a better protection of the damaged organ.
Toledo-Pereyra
L H
LH
Departamento de Investigación y Trasplantes, Borgess Medical Center, Kalamazoo, Mich.
D000818:Animals; D016166:Free Radical Scavengers; D005609:Free Radicals; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D015427:Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism*
D016166:Free Radical Scavengers; D005609:Free Radicals
Mecanismos de daño neutrófilo-oxígeno en la lesión de isquemia y reperfusión. Manipulaciones farmacológicas.