Chromosomal assignment in mouse of matrix Gla protein and bone Gla protein genes.
Matrix Gla protein (MGLAP) and bone Gla protein (BGLAP) are calcium-binding, vitamin K-dependent proteins produced by cells of the osteoblastic lineage. Sequence homology suggests that the genes for these proteins evolved from a common ancestor. Somatic whole cell hybrids and karyotypically simple microcell hybrids were used to map Mglap to mouse Chromosome 6 and Bglap to mouse Chromosome 3. Human MGLAP has previously been mapped to chromosome 12p, a region with homology to mouse Chromosome 6, and human BGLAP has been mapped to chromosome 1q, a region with homology to mouse Chromosome 3. It appears that BGLAP is the third calcium-binding protein that maps to human chromosome 1q and mouse Chromosome 3.
Johnson
T L
TL
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
Sakaguchi
A Y
AY
Lalley
P A
PA
Leach
R J
RJ
D015055:1-Carboxyglutamic Acid / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D015342:DNA Probes / Q000235:genetics; D016326:Extracellular Matrix Proteins; D006822:Hybrid Cells; D051379:Mice; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000235:genetics; D015675:Osteocalcin / Q000235:genetics*; D016133:Polymerase Chain Reaction; D051381:Rats; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D000097568:Matrix Gla Protein
D015055:1-Carboxyglutamic Acid; D002135:Calcium-Binding Proteins; D015342:DNA Probes; D016326:Extracellular Matrix Proteins; D009838:Oligodeoxyribonucleotides; D015675:Osteocalcin; D000097568:Matrix Gla Protein