Penetration of antibiotics through omiderm in vitro and on split-thickness skin grafts in burn patients.
Penetration of antibiotic preparations (gentamicin, neomycin, silver sulfadiazine, mupirocin) through Omiderm, a synthetic wound covering, was tested in vitro and in 5 patients with full-thickness burns who had undergone tangential excision and split-thickness skin grafting. All antibiotic preparations tested penetrated both meshed and unmeshed Omiderm. Omiderm did not affect the zones of inhibition of antimicrobial activity as compared with controls.
Russavage
J M
JM
General Surgery Department, University of Pittsburgh, Presbyterian University Hospital, PA.
Slater
H
H
Goldfarb
I W
IW
Hammell
E J
EJ
D000042:Absorption / Q000187:drug effects; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001458:Bandages; D002056:Burns / Q000188:drug therapy* / Q000601:surgery; D005069:Evaluation Studies as Topic; D006801:Humans; D010539:Permeability / Q000187:drug effects; D011140:Polyurethanes / Q000592:standards*; D016038:Skin Transplantation / Q000592:standards*
D000900:Anti-Bacterial Agents; D011140:Polyurethanes; C045685:omiderm