title: Evaluation of total serum bile acid concentrations for the diagnosis of hepatobiliary disease in cattle.
abstract: Serum bile acid concentrations were measured in 41 clinically healthy cattle of different breeds. There was no diurnal variation in values and age and sex had no effect. There was no significant difference between serum and plasma bile acid concentrations in clinically healthy cattle. Serum bile acids were stable on storage at -20 degrees C. The total serum bile acid concentrations, together with other tests of hepatic disease, were evaluated in cattle with various types of hepatobiliary disease (hepatic lipidosis, hepatic abscessation, leptospirosis, biliary calculi, fascioliasis), respiratory, cardiovascular and infectious diseases, and in various other conditions not affecting the liver. Total serum bile acids were the most specific and sensitive indicators of a wide variety of hepatic diseases and were significantly correlated with the degree of clinical illness.
authors.affiliation: Department of Veterinary Clinical Science, Leahurst, University of Liverpool, Neston, South Wirral.
authors.forename: H J
authors.initials: HJ
authors.lastname: West
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood*; D001660:Biliary Tract Diseases / Q000175:diagnosis / Q000662:veterinary*; D001793:Blood Preservation; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis*; D005069:Evaluation Studies as Topic; D008099:Liver / Q000201:enzymology; D008107:Liver Diseases / Q000175:diagnosis / Q000662:veterinary*; D011237:Predictive Value of Tests; D013448:Sulfobromophthalein / Q000493:pharmacokinetics
chemical_list: D001647:Bile Acids and Salts; D013448:Sulfobromophthalein