Reduced fluid volume requirement for resuscitation of third-degree burns with high-dose vitamin C.
The effects of high-dose vitamin C therapy (170 mg, 340 mg, and 680 mg/kg/day) were evaluated in 70% body surface area third-degree burns in guinea pigs that were resuscitated with 1 ml/kg/%burn Ringer's lactate solution. The water content measurements of the burned skin at 24 hours after burn injury in the vitamin C-treated groups were significantly lower than those of the control group (1 ml/kg/%burn) and those of the standard resuscitation group (4 ml/kg/%burn). The cardiac outputs in the group that received 340 mg vitamin C were significantly higher than those of the control group but not significantly different than those of the standard therapy group at 2 hours after burn injury and thereafter. In comparison with the regimen of 340 mg vitamin C, the regimen of 680 mg vitamin C was no more beneficial, and the regimen of 170 mg was less effective. With administration of adjuvant high-dose vitamin C, we were able to reduce the total 24-hour resuscitation volume from 4 ml/kg/%burn to 1 ml/kg/%burn, while a comparable cardiac output was maintained.
Matsuda
T
T
Burn Center, Cook County Hospital, Chicago, IL 60612.
Tanaka
H
H
Williams
S
S
Hanumadass
M
M
Abcarian
H
H
Reyes
H
H
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D002056:Burns / Q000503:physiopathology / Q000628:therapy*; D002199:Capillary Permeability / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D005440:Fluid Therapy; D016166:Free Radical Scavengers; D006168:Guinea Pigs; D007552:Isotonic Solutions / Q000008:administration & dosage; D012151:Resuscitation / Q000379:methods*; D000077325:Ringer's Lactate; D013997:Time Factors
D016166:Free Radical Scavengers; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D001205:Ascorbic Acid