title: Influence of gonadectomy and testosterone supplementation on the postnatal development of the vasopressin and oxytocin-containing nucleus of the pig hypothalamus.
abstract: We have studied the effects of gonadectomy and testoterone supplementation on the development of the vasopressin- and oxytocin-containing nucleus (VON) of the pig hypothalamus that shows a decrease in neuron number during the first weeks postnatally, followed by an increase during puberty. Neonatal gonadectomy caused a 2.5-fold increase in VON volume and neuron number in males and 3-fold in females at the age of 16 weeks, the onset of puberty. However, the difference between gonadectomized and nongonadectomized animals disappeared after puberty (38 weeks). Testosterone replacement from 16 weeks onwards induced a decrease in neuron number and volume of the VON. The present study indicates that the development of the VON is influenced by gonadal steroids although it seems improbable that these hormones affect the VON directly.
authors.affiliation: Department of Functional Morphology, Faculty of Veterinary Science, University of Utrecht, The Netherlands.
authors.forename: F J
authors.initials: FJ
authors.lastname: van Eerdenburg
authors.forename: C M
authors.initials: CM
authors.lastname: Lugard-Kok
authors.forename: S J
authors.initials: SJ
authors.lastname: Dieleman
authors.forename: M M
authors.initials: MM
authors.lastname: Bevers
authors.forename: D F
authors.initials: DF
authors.lastname: Swaab
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D002369:Castration; D002452:Cell Count; D005260:Female; D007031:Hypothalamus / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009474:Neurons / Q000166:cytology; D010121:Oxytocin / Q000378:metabolism*; D012741:Sexual Maturation; D013552:Swine; D013739:Testosterone / Q000097:blood / Q000494:pharmacology*; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D014667:Vasopressins; D013739:Testosterone; D010121:Oxytocin; D007986:Luteinizing Hormone