The role of midline ventral medullary structures in generation of respiratory motor high frequency oscillations.
Lesions 1-2 mm deep in the midline of the ventral medulla (VM) abolished high frequency oscillations (HFO) in the respiratory motor output in cat and rabbit. Raising arterial pCO2 increased phrenic nerve activity to its prelesion level but did not restore HFO. We conclude that the neuronal pathways crossing the midline of the VM are crucial for reinforcement of respiratory activity and HFO generation.
Romaniuk
J R
JR
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Bruce
E N
EN
D000818:Animals; D002415:Cats; D004525:Efferent Pathways / Q000502:physiology; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000502:physiology*; D010791:Phrenic Nerve / Q000502:physiology*; D011817:Rabbits; D012119:Respiration; D014630:Vagus Nerve / Q000502:physiology*