title: Osteomalacia secondary to renal tubular acidosis in a patient with primary Sjögren's syndrome.
abstract: We report a case of a 41-year-old woman whose disease manifested as osteomalacia and whose etiological investigation revealed renal tubular acidosis secondary to primary Sjögren's syndrome. Proximal tubular dysfunction was also present and was documented by increased urinary excretion of beta-2-microglobulin and retinol-binding protein. The patient showed clinical and laboratory improvement after treatment with oral potassium citrate, calcium supplements and steroids.
authors.affiliation: Department of Medicine, Escola Paulista de Medicina, Sao Paulo, Brazil.
authors.forename: J T
authors.initials: JT
authors.lastname: Monte Neto
authors.forename: R
authors.initials: R
authors.lastname: Sesso
authors.forename: G M
authors.initials: GM
authors.lastname: Kirsztajn
authors.forename: L C
authors.initials: LC
authors.lastname: Da Silva
authors.forename: A B
authors.initials: AB
authors.lastname: De Carvalho
authors.forename: A B
authors.initials: AB
authors.lastname: Pereira
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D000328:Adult; D002118:Calcium / Q000627:therapeutic use; D002951:Citrates / Q000627:therapeutic use; D019343:Citric Acid; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000209:etiology; D007687:Kidney Tubules, Proximal / Q000502:physiology; D010018:Osteomalacia / Q000209:etiology*; D012177:Retinol-Binding Proteins / Q000652:urine; D012859:Sjogren's Syndrome / Q000150:complications*; D013256:Steroids / Q000627:therapeutic use; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D002951:Citrates; D012177:Retinol-Binding Proteins; D013256:Steroids; D001613:beta 2-Microglobulin; D019343:Citric Acid; D002118:Calcium