title: Histology of joint inflammation induced in rats by cell wall fragments of the anaerobic intestinal bacterium Eubacterium aerofaciens.
abstract: To study the arthropathic properties of human intestinal bacteria, cell wall fragments (CWF) of the anaerobic bowel bacterium Eubacterium aerofaciens were injected intraperitoneally (i.p.) in arthritis-susceptible Lewis rats. Rat paw joints were subsequently studied for histopathological changes. A persisting synovitis accompanied by marginal erosions of cartilage and bone and a marked periosteal apposition of new bone tissue were the main features of the polyarthritis induced. These results are discussed in relation to streptococcal cell wall induced arthritis and compared with histopathological findings in rheumatoid arthritis (RA) in man.
authors.affiliation: Department of Immunology, Erasmus University, Rotterdam, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Severijnen
authors.forename: R
authors.initials: R
authors.lastname: van Kleef
authors.forename: A A
authors.initials: AA
authors.lastname: Grandia
authors.forename: T H
authors.initials: TH
authors.lastname: van der Kwast
authors.forename: M P
authors.initials: MP
authors.lastname: Hazenberg
mesh_terms: D000818:Animals; D001170:Arthritis, Infectious / Q000209:etiology / Q000473:pathology*; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000382:microbiology / Q000473:pathology*; D001424:Bacterial Infections / Q000209:etiology / Q000473:pathology*; D002462:Cell Membrane / Q000502:physiology / Q000648:ultrastructure; D002908:Chronic Disease; D004195:Disease Models, Animal; D005051:Eubacterium / Q000502:physiology* / Q000648:ultrastructure; D005260:Female; D006614:Hindlimb; D007274:Injections, Intraperitoneal; D007422:Intestines / Q000382:microbiology*; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors