[Suppression of development of autoimmune thyroiditis during prolonged stimulation of T-cellular immunity].
The purpose of this experiment was to investigate the suppression of autoimmune thyroiditis in guinea-pigs by prolonged stimulation of T-cellular immunity with T-activin, a thymic hormone. The development of experimental autoimmune thyroiditis (EAT) at early stages was shown to be characterized by deficiency of T-cells of helper and suppressor phenotypes, hypersecretion of thyroid hormones and insignificant development of a thyroid autoimmune process. With disease development indices of peripheral blood immunity of guinea-pigs were close to normal, and the frequency and degree of lymphoid infiltration of the gland were increased in parallel with the development of hypofunction of the organ. Immuno-correction of developing EAT with injections of T-activin according to our scheme resulted in a prolonged stimulation of T-cellular immunity, prevented sensitization of lymphocytes with thyroid antigens, increased secretion of the thymic hormones in parallel with a decrease in a degree of lymphoid-plasmacytic infiltration from thyroid tissues, indicating suppression of the disease.
Artemova
E P
EP
Nugmanova
L B
LB
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000502:physiology; D016130:Immunophenotyping; D010455:Peptides / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology*; D013949:Thymus Extracts / Q000627:therapeutic use*; D013963:Thyroid Hormones / Q000378:metabolism; D013967:Thyroiditis, Autoimmune / Q000276:immunology / Q000517:prevention & control*
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; D013963:Thyroid Hormones; C036191:T-activin
Supressiia razvitiia éksperimental'nogo autoimmunnogo tireoidita v protsesse dlitel'noĭ stimuliatsii T-kletochnogo immuniteta.