title: Histopathology and doxycycline treatment in a previously healthy non-AIDS patient systemically infected by Mycoplasma fermentans (incognitus strain).
abstract: The newly recognized human pathogenic mycoplasma M. fermentans (incognitus strain) causes a fatal systemic infection in experimental monkeys, infects patients with AIDS, and apparently is associated with a fatal disease in previously healthy non-AIDS patients. An apparently immunocompetent male who lacked evidence of HIV infection developed fever, malaise, progressive weight loss, and diarrhea and had extensive tissue necrosis involving liver and spleen. M. fermentans (incognitus strain) was centered at the advancing margins of these necrotizing lesions. Following the treatment of 300 mg doxycycline per day for 6 weeks, he recovered fully. He has no fever or diarrhea, and his abnormal liver function tests have returned to normal. He regained all lost strength and 14 kg of lost weight and has remained disease free for more than 1 year.
authors.affiliation: Department of Infectious and Parasitic Diseases Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000.
authors.forename: S C
authors.initials: SC
authors.lastname: Lo
authors.forename: C L
authors.initials: CL
authors.lastname: Buchholz
authors.forename: D J
authors.initials: DJ
authors.lastname: Wear
authors.forename: R C
authors.initials: RC
authors.lastname: Hohm
authors.forename: A M
authors.initials: AM
authors.lastname: Marty
mesh_terms: D000163:Acquired Immunodeficiency Syndrome; D000328:Adult; D004318:Doxycycline / Q000627:therapeutic use*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009175:Mycoplasma Infections / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D016858:Mycoplasma fermentans; D011860:Radiography, Abdominal; D014057:Tomography, X-Ray Computed
chemical_list: D004318:Doxycycline