[Aluminum and fluorine absorption in a perfusion system of rat small intestine in vivo].
Mixtures of aluminum an fluorine in two different ratios in tris-hydroxy-methyl-aminomethane buffered media of pH 7.0 were perfused respectively through the small intestine of the in vivo rat over a period of 40 min. The contents of aluminum and fluorine in the portal vein blood obtained from different perfusion periods were detected and determined simultaneously. The results showed that fluorine absorption was not significant in the mixtures. An obviously large amount of aluminum was absorbed in the mixture with a higher proportion of aluminum (4660 micrograms/ml Al + 200 micrograms/ml F/L), while in the mixture with a lower dose of aluminum (860 micrograms/ml Al + 200 micrograms F/L), a small quantity of aluminum was absorbed. It is evident that the mechanism by which aluminum inhibits fluorine toxicity is that aluminum decreases the intestinal fluorine absorption by the formation of aluminum fluoride complex.
Li
D
D
Institute of Toxicology, School of Public Health.
Xiao
B
B
Dong
Q
Q
Li
S
S
Zhan
C
C
D000535:Aluminum / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D005461:Fluorine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D010477:Perfusion; D011169:Portal Vein; D051381:Rats; D011919:Rats, Inbred Strains
D005461:Fluorine; D000535:Aluminum