[Regulatory effects of human mononuclear cells treated with diucifon may be dependent on membrane-associated form of interleukin-2].
The immunomodulating activity of diucifon--activated and glutaraldehyde fixed human mononuclear cells (MNC-DGA) was studied in the test--system of autologous and allogenic mononuclear cells proliferative response. It was shown that MNC-DGA had the same stimulating activity as the diucifon treated unfixed cells. The immunomodulating capacity of MNC-DGA was fully abolished in the case MNC-DGA. So, the interaction between interleukin 2 receptor (Tac--antigen) and the membrane form of the mediator, expressed on MNC after diucifon treatment may play an important role in MNC-DGA immunomodulating activity. The regulating activity of MNC-DGA was revealed both in autologous and allogenic systems. The speculation is that construction of new immunomodulating drugs as complexes of cell-like carrier and immunomodulators fixed on their surface may be perspective.
Prozorovskiĭ
N S
NS
Leskov
V P
VP
Gushchin
I S
IS
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D002478:Cells, Cultured; D003470:Culture Media; D004338:Drug Combinations; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis / Q000276:immunology*; D008954:Models, Biological; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000276:immunology; D013450:Sulfones / Q000494:pharmacology*; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000911:Antibodies, Monoclonal; D003470:Culture Media; D004338:Drug Combinations; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D013450:Sulfones; C023367:diucifon; D014498:Uracil
Reguliatornoe deĭstvie mononuklearnykh kletok cheloveka, obrabotannykh diutsifonom, mozhet oposredovat'sia membranoassotsiirovannoĭ formoĭ interleĭkina -2.