[Sensitivity of human glial tumor cells of different grade of anaplasia to lysis due to natural killers depending on some characteristics of the glycoprotein structure of tumor cell membranes].
A study is presented of the sensitivity of freshly isolated cells (13 cases) to lysis due to natural killers (NK) depending on their malignancy grade and degree of their membrane sialization. The diagnoses were verified histologically (I-II grade gliomas-4 cases, grade III gliomas-3 cases, grade IV gliomas-6 cases). It was established that grade IV gliomas were most sensitive to NK-lysis. Treatment of tumor cells with neuraminidase increased the sensitivity to NK-lysis of grade I-III glioma cells and did not influence the sensitivity of grade IV gliomas. It is suggested that glycoprotein oligosaccharides of glial tumour cell membranes may play the role of target structures for lymphocytes-killers.
Lisianyĭ
K I
KI
Markova
O V
OV
Romodanov
S A
SA
D001254:Astrocytoma / Q000276:immunology*; D005910:Glioma / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000032:analysis*; D009439:Neuraminidase / Q000494:pharmacology; D009844:Oligosaccharides / Q000032:analysis; D014407:Tumor Cells, Cultured
D008562:Membrane Glycoproteins; D009844:Oligosaccharides; D009439:Neuraminidase
Chuvstvitel'nost' kletok glial'nykh opukholeĭ cheloveka raznoĭ stepeni anaplazii k lizisu, oposredovannomu estestvennymi killerami, v zavisimosti ot nekotorykh osobennosteĭ glikoproteidnoĭ struktury membran opukholevykh kletok.