[The mechanism of the therapeutic effect of periodontal cytomedin on the course of experimental periodontitis].
Periodontitis induction causes a drastic elevation of free-radical lipid peroxidation, of ceruloplasmin level, and a reduction of antioxidant enzyme activities. Blood analysis shows hypercoagulation, appearance of paracoagulation products, reduced fibrinolysis, enhanced proaggregation activity of the periodontium, elevated levels of circulating immune complexes; this may by regarded as adaptation failure manifesting by these reactions. Morphologic examinations show foci of destructive changes. Administration of periodontal cytomedin reduced the level of free-radical oxidation, enhanced the activity of antioxidant enzymes, normalized antiaggregation activity of the periodontium and hemostasis and fibrinolysis parameters, and reduced the level of circulating immune complexes. The inflammatory reaction disappears completely, that is seen from reduced ceruloplasmin level and clinically. Morphologic study shows disappearance of foci of destruction. Thus, cytomedin of periodontal tissues may be regarded as an effective agent for the therapy of experimental periodontitis.
Silenko
Iu I
IuI
Mishchenko
V P
VP
Tokar'
D L
DL
Khavinson
V Kh
VKh
Zhukova
M Iu
MIu
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D010455:Peptides / Q000627:therapeutic use*; D010518:Periodontitis / Q000097:blood / Q000188:drug therapy*; D010519:Periodontium / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D005609:Free Radicals; D010455:Peptides; C053892:cytomedins
Mekhanizm terapevticheskogo éffekta tsitomedina iz parodonta na techenie éksperimental'nogo parodontita.