Octamania: the POU factors in murine development.
Much effort has been directed towards the investigation of regulatory processes in the early mouse embryo. Several multigene families of developmental control genes have been identified. The POU family is a group of related transcription factors containing a particular type of bipartite DNA-binding domain. Members of this family show distinct expression patterns during embryonic development. Two members, Oct-4 and Oct-6, are expressed as early as in the preimplantation embryo and thus may regulate early events of murine development.
Schöler
H R
HR
Max-Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG.
D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D050814:Octamer Transcription Factor-3; D050816:Octamer Transcription Factor-6; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D004268:DNA-Binding Proteins; D050814:Octamer Transcription Factor-3; C494178:POU3F1 protein, human; C494173:POU5F1 protein, human; C494180:Pou3f1 protein, mouse; C494174:Pou5f1 protein, mouse; D014157:Transcription Factors; D050816:Octamer Transcription Factor-6