Clubbing associated with oesophageal adenocarcinoma.
A patient with an oesophageal adenocarcinoma, recent onset of digital clubbing, and evidence of increased oestrogen synthesis is presented. In the discussion, some of the theories of the pathogenesis of clubbing are reviewed, together with previous reports of clubbing in gastro-oesophageal disorders. A possible unifying theory is proposed for our case which we believe is the first report of this triple association.
Polkey
M I
MI
Department of Medicine, Greenwich District Hospital, London, UK.
Cook
G R
GR
Thomson
A D
AD
Taylor
N F
NF
D000230:Adenocarcinoma / Q000150:complications* / Q000378:metabolism; D000368:Aged; D004938:Esophageal Neoplasms / Q000150:complications* / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D004964:Estriol / Q000652:urine; D004967:Estrogens / Q000096:biosynthesis; D004970:Estrone / Q000652:urine; D005260:Female; D006801:Humans; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology* / Q000378:metabolism
D004967:Estrogens; D004970:Estrone; D004958:Estradiol; D004964:Estriol