Effects of single and repeated marijuana smoke exposure on fetal EEG.
The effect of single and repeated marijuana smoke exposure on fetal EEG was investigated in the chronic fetal lamb model using power spectral analysis. Maternal inhalation of marijuana smoke (n = 9) resulted in a significant reduction in total power and power distribution in the delta (1-4 Hz) band, and an increase in power distribution in the faster frequencies in the first h after smoke inhalation. These EEG changes were not observed following maternal inhalation of placebo smoke (n = 5), nor in animals with 3-5 prior exposures to marijuana smoke (n = 5). These results suggest that the effects of marijuana smoke exposure on fetal EEG is short-lived and tolerance develops rapidly with repeated exposure.
Szeto
H H
HH
Department of Pharmacology, Cornell University Medical College, New York, NY 10021.
Wu
D L
DL
Decena
J A
JA
Cheng
Y
Y
D000818:Animals; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000502:physiology*; D008385:Marijuana Smoking / Q000503:physiopathology*; D011247:Pregnancy; D012756:Sheep