Predictors of pregnancy success in repeated miscarriage.
Factors that may have a bearing on subsequent pregnancy success or failure in patients with recurrent abortion were examined in 165 women with a history of three or more consecutive miscarriages in the first trimester. The overall success rate was 67.9%. Factors that were found to correlate significantly with success rate were length of abortion history, total number of abortions, interval from last miscarriage to present pregnancy, and whether there was any degree of subfertility. Logistic regression analysis showed that the abortion x years index and maternal age accounted for all the variation observed in our data. Where all other known causes of abortions are excluded, recurrent aborters can be subdivided into two populations--namely, those with a relatively good prognosis characterized by a short abortion history and absence of subfertility problems, compared to those with a poor prognosis namely those with a long abortion history or presence of subfertility problems. These data clearly demonstrate major differences in success rates in women depending on the number of abortions and the length of abortion history (abortion x year index), particularly in women over the age of 30 years.
Cauchi
M N
MN
Royal Women's Hospital, Carlton, Melbourne, Australia.
Pepperell
R
R
Kloss
M
M
Lim
D
D
D000026:Abortion, Habitual / Q000209:etiology / Q000276:immunology / Q000628:therapy; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology; D008423:Maternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D012044:Regression Analysis; D013997:Time Factors