Exhalation of metallic mercury by acatalasemic, hypocatalasemic and normal mice exposed to metallic mercury vapor.
In order to elucidate the amounts of metallic mercury exhaled from mice having different amounts of catalase activity, normal, homozygous hypocatalasemic and acatalasemic mice were exposed to radioactive metallic mercury vapor at three levels of concentrations (0.072, 0.144, and 0.297 mg/m3). The timed and cumulative amounts of metallic mercury exhaled from the mice were used to classify them, in the descending order, as being acatalasemic, hypocatalasemic, and normal at the three environmental mercury concentrations. The statistical differences in the mean values among the acatalasemic, hypocatalasemic, and normal mice were calculated by the use of one-way ANOVA and multiple comparison of the mean values by Tukey's method. The mean values of the timed amounts of exhaled metallic mercury were found to be significantly different (P less than 0.05) among the three kinds of mice several hours after exposure, and those of the cumulative amounts of exhaled metallic mercury were in the descending order of acatalasemic, hypocatalasemic and normal mice, and were significantly different among the three types of mice almost over the entire time course. Thus, negative correlation coefficients were obtained between the logarithms of the catalase activity in the lungs and the blood, and the logarithms of the cumulative amounts of exhaled metallic mercury.
Meguro
T
T
Department of Public Health, Okayama University Medical School, Japan.
Ogata
M
M
D020642:Acatalasia; D000280:Administration, Inhalation; D000388:Air / Q000032:analysis; D000818:Animals; D002374:Catalase / Q000097:blood; D007202:Indicators and Reagents; D008168:Lung / Q000201:enzymology; D008297:Male; D008628:Mercury / Q000378:metabolism*; D008631:Mercury Radioisotopes; D051379:Mice; D008809:Mice, Inbred C3H
D007202:Indicators and Reagents; D008631:Mercury Radioisotopes; D002374:Catalase; D008628:Mercury