Treatment of adult acute myelogenous leukemia: a pilot study at Chulalongkorn Hospital.
Twenty-seven patients with acute myelogenous leukemia (AML), aged 15 to 65 years, were treated with standard induction remission chemotherapy and two different strategies for postremission treatment. Seventeen patients (63%) achieved complete remission (CR). Nine patients (37%) died during marrow hypoplasia. The median survival of complete remitters allocated to the intensive postremission therapy is projected to be in excess of 24 months with 53 per cent probability of remaining in CR at two years. The median remission duration for patients who entered the nonintensive postremission therapy was 11 months. Age was the major factor significantly correlated with the outcome of treatment. It is concluded that intensive curative treatment should be indicated in AML patients who are less than 30 years.
Intragumtornchai
T
T
Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Sucharitchan
P
P
Swasdikul
D
D
Mahasandhana
S
S
Watananukul
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D001853:Bone Marrow / Q000187:drug effects; D002423:Cause of Death; D003561:Cytarabine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012074:Remission Induction / Q000379:methods*; D015996:Survival Rate; D013785:Thailand / Q000453:epidemiology; D016896:Treatment Outcome
D003561:Cytarabine; D004317:Doxorubicin