title: Modulation of enzyme specificity by site-directed mutagenesis.
authors.forename: L
authors.initials: L
authors.lastname: Hedstrom
authors.forename: L
authors.initials: L
authors.lastname: Graf
authors.forename: C B
authors.initials: CB
authors.lastname: Stewart
authors.forename: W J
authors.initials: WJ
authors.lastname: Rutter
authors.forename: M A
authors.initials: MA
authors.lastname: Phillips
mesh_terms: D000595:Amino Acid Sequence; D002918:Chymotrypsin / Q000235:genetics; D004798:Enzymes / Q000737:chemistry* / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D009841:Oligonucleotides / Q000138:chemical synthesis; D016133:Polymerase Chain Reaction; D011487:Protein Conformation; D015202:Protein Engineering; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D012697:Serine Endopeptidases / Q000737:chemistry / Q000235:genetics; D013379:Substrate Specificity; D014357:Trypsin / Q000235:genetics; D015003:Yeasts / Q000235:genetics
chemical_list: D004798:Enzymes; D009841:Oligonucleotides; D012697:Serine Endopeptidases; D002918:Chymotrypsin; D014357:Trypsin