[Possibility of directed changes in the surface activity of rat pulmonary surfactants by means of exposure to antibodies specific to them].
The experiments were performed on Wistar rats with weight of 150-200 g. Antibodies were prepared by immunization of rabbits with pure surfactants of rat lungs and were intravenously injected into rats three times within 3 days intervals. These antibodies were shown to influence the superficial activity of lung surfactants and the alveolar lung cells activity. The low doses of antibodies (0.06 micrograms of protein per 100 g of body mass) stimulated the superficial activity of lung surfactants, while higher doses (3 mg of protein per 100 g of body mass) inhibited it.
Berezovskiĭ
V A
VA
Gorchakov
V Iu
VIu
Alekseeva
I N
IN
Bogomolets
E O
EO
Andrianova
I V
IV
Makogon
N V
NV
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D011663:Pulmonary Surfactants / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D000911:Antibodies, Monoclonal; D011663:Pulmonary Surfactants
Vozmozhnost' napravlennykh izmeneniĭ poverkhnostnoĭ aktivnosti surfaktantov legkogo krys putem vozdeĭstviia spetsificheskimi k nim antitelami.