[Environmentally-induced causes of aging-dependent DNA modifications and possible consequences: current methods for the assessment of genotoxic potential of mixed pollution].
The deoxyribonucleic acid (DNA) is subject of a series of modifications with time, which are connected with the development of cancer and the process of aging. However, an efficient and nearly perfect repair system works against them, which eliminates most but not all of these changes. A series of tests has been developed for assessment of genotoxic potential of compounds and mixed pollution of environment. Three fast assay systems (umu test, DIT test, and Visko test) are discussed, whose results are obtained more quickly than by using conventional methods (e.g., Ames test or sister chromatid exchange).
Schröder
H C
HC
Institut für Physiologische Chemie, Mainz.
Zahn
R K
RK
Müller
W E
WE
D000375:Aging / Q000235:genetics*; D004249:DNA Damage; D004260:DNA Repair; D003641:Deamination; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D009152:Mutagenicity Tests; D011687:Purines / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects; D013941:Thymine / Q000378:metabolism
D004785:Environmental Pollutants; D011687:Purines; D013941:Thymine
Umweltbedingte Ursachen alternsabhängiger DNA-Veränderungen und mögliche Konsequenzen: Neue Methoden zur Erfassung des gentoxischen Potentials von Mischpollutionen.