Synthesis and preliminary pharmacological assessment of novel 9-substituted pyrimidino-[2,1-f]-purines.
Synthesis, chemical properties and results of preliminary pharmacological evaluation of several new 9-substituted pyrimidino-[2,1-f]-purines are described. The most interesting was 1,3-dimethyl-2,4,8-trioxo-9-[gamma-N1-(N4-C6H5)-piperazynopropy l]-1,3,6,7-tetrahydro-9H-pyrimidino-[2,1-f]-purine (compound 4a), which exerted strong sedative, hypothermizing and cataleptogenic action and possessed some anti-amphetamine and anti-apomorphine properties.
Pawłowski
M
M
Department of Pharmaceutical Chemistry, Medical Academy, Kraków, Poland.
Drabczyńska
A
A
Gorczyca
M
M
Malec
D
D
Modzelewski
J
J
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants; D000928:Antidepressive Agents / Q000494:pharmacology; D001058:Apomorphine / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced; D006220:Haloperidol / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000037:antagonists & inhibitors; D013055:Spectrophotometry, Infrared; D013239:Stereotyped Behavior / Q000187:drug effects
D000927:Anticonvulsants; D000928:Antidepressive Agents; D011687:Purines; D011744:Pyrimidinones; D012110:Reserpine; D000661:Amphetamine; D006220:Haloperidol; D001058:Apomorphine