The effect of bile acids on the growth and adherence of Helicobacter pylori.
Bile reflux gastritis occurs in the absence of Helicobacter pylori (H. pylori). The aim of this study was to see if the bile acids cheno or ursodeoxycholic acid affected the growth or adherence of H. pylori in vitro. Twenty-seven strains growth were inhibited by 0.1% chenodeoxycholic acid whereas only 11 out of the 27 were inhibited by 0.1% ursodeoxycholic acid. Growth was totally inhibited by a combination of 0.05% chenodeoxycholic acid +0.05% ursodeoxycholic acid. Chenodeoxycholic acid was a more effective inhibitor of adherence in that the number inhibited and percentage inhibition were greater than with ursodeoxycholic acid. Bile salts might be useful in the treatment of H. pylori infection.
Mathai
E
E
Department of Clinical Microbiology Trinity College, St James's Hospital, Dublin, Eire.
Arora
A
A
Cafferkey
M
M
Keane
C T
CT
O'Morain
C
C
D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002635:Chenodeoxycholic Acid / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000166:cytology / Q000187:drug effects*; D006736:Horses; D014580:Ursodeoxycholic Acid / Q000494:pharmacology*
D002635:Chenodeoxycholic Acid; D014580:Ursodeoxycholic Acid