Nephrotoxicity of aminoglycosides, polypeptides and cephalosporins in cancer patients.
The nephrotoxicity of various combinations of antibiotics--aminoglycosides, cephalosporins, vancomycin, amphotericin B--in 171 oncologic patients is described. The most nephrotoxic combination seems to be cefotaxime plus gentamicin, ceftriaxone plus amikacin and amphotericin B with cephalosporin, vancomycin or aminoglycoside. Less toxic was netilmicin with penicillin or cephalosporin, and vancomycin.
Krcméry
V
V
Department of Clinical Oncology, Postgraduate Medical Institute, Bratislava, Czechoslovakia.
Fuchsberger
P
P
Gocár
M
M
Salát
T
T
Bodnárová
J
J
Sobota
R
R
Koza
I
I
Svec
J
J
D000617:Aminoglycosides; D000666:Amphotericin B / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D009369:Neoplasms / Q000150:complications*; D012189:Retrospective Studies; D014640:Vancomycin / Q000009:adverse effects*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D014640:Vancomycin; D000666:Amphotericin B