[Vitamin E and its structural analogs in tuberculosis].
Efficiency of tocopherol, its analog with a shortened side chain as well as their quinons for tuberculosis was determined. All the studied compounds inhibited peroxide-formation processes in the liver homogenate and mitochondria. The vitamin E amount in the blood is considerably decreased in case of tuberculosis. The studied analogs increased its content and possessed a weak tuberculostatic but expressed antiedemic and antiinflammatory action. Administration of vitamin E in combination with isoniazid to sick animals had a favourable effect on the processes of tissue respiration and oxidative phosphorylation. If taking a sum of characters, tocopherol acetate with a shortened side chain is the most efficient of all the analogs under study for the tuberculosis therapy.
Panasiuk
A V
AV
Penenko
O R
OR
Kuz'menko
I V
IV
Suslov
E I
EI
Klimenko
M T
MT
Kuznitsa
N I
NI
Tumanova
T A
TA
Makovetskiĭ
V P
VP
Donchenko
G V
GV
D000818:Animals; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D007538:Isoniazid / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011809:Quinones / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014810:Vitamin E / Q000031:analogs & derivatives / Q000627:therapeutic use*
D011809:Quinones; D014810:Vitamin E; D007538:Isoniazid
Vitamin E i ego strukturnye analogi pri tuberkuleze.