[The anticonvulsant activity of digoxin in rats of different ages and in mice].
The anticonvulsant activity of digoxin was studied on rats of different ages and mice. Cramps were simulated by using electroshock or a subcutaneous administration of bemegrid or corasol. The effect of digoxin (in the doses amounting to 1/10 or 1/2 of LD50) on the time of the onset of cramps, the duration of tonic and clonic phases as well as the number of the deceased animals was evaluated. The detected anticonvulsant effect of digoxin is explained by its influence on the activity of the membrane Na+, K+, ATP-ase and K+ conductivity.
Mikhaĭlov
I B
IB
Sukhov
R R
RR
D000375:Aging / Q000187:drug effects*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001534:Bemegride; D004077:Digoxin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000209:etiology / Q000401:mortality / Q000517:prevention & control
D000927:Anticonvulsants; D001534:Bemegride; D004077:Digoxin; D010433:Pentylenetetrazole
Protivosudorozhnaia aktivnost' digoksina u krys raznogo vozrasta i mysheĭ.