Effects of anti-arthritic drugs on IL-1 induced inflammation in rats.
Intra-articular injection of IL-1 in rats results in profound changes in the synovial joints including edema, synovitis, cartilage degeneration and fibroblast proliferation. We have tested the efficacy of several anti-arthritic drugs in this model to characterize the mechanism of IL-1 induced inflammatory lesions. The response to IL-1 was evaluated by measurement of soft-tissue swelling and by histological scoring. Dexamethasone, and several NSAIDS were effective in reducing the soft tissue swelling but only some were effective in improving the histological lesions. The slow-acting antirheumatic D-penicillamine and immunosuppressive agents such as cyclosporine A were ineffective. These observations provide further evidence that in vivo, at least some aspects of IL-1 induced changes in rat knee joints are likely to be prostaglandin mediated.
Hrubey
P S
PS
Department of Connective Tissue and Monoclonal Antibody Research, Lilly Research Laboratories, Indianapolis, IN 46285.
Harvey
A K
AK
Bendele
A M
AM
Chandrasekhar
S
S
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D003907:Dexamethasone / Q000494:pharmacology; D006614:Hindlimb; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007270:Injections, Intra-Articular; D007375:Interleukin-1 / Q000008:administration & dosage / Q000633:toxicity*; D007596:Joints / Q000473:pathology; D051381:Rats; D011994:Recombinant Proteins
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D007375:Interleukin-1; D011994:Recombinant Proteins; D003907:Dexamethasone