title: [Short- and long-term results of multimodal treatment program of lymphogranulomatosis (Hodgkin's disease) in children and adolescents].
abstract: Short- and long-term results of combined treatment of 440 children and adolescents afflicted with lymphogranulomatosis (Hodgkin's disease) were traced. A group of 104 children received treatment in 1964-1973. Complete effect was attained in 72.1% of the patients (in 75 out of 104); the 5-year survival was 72.5%, the 10-year 61.1%, the 15-year 52.75%. The long-term results are described in detail. Analysis of the results allowed basing the necessity of the three-stage combined chemoradiation therapy in children with lymphogranulomatosis. In 1976-1980, the treatment according to the first combined program was provided to 193 children and adolescents aged 2.5 to 16 years suffering from lymphogranulomatosis. In 1979-1983, the treatment according to the second combined program was provided to 143 children and adolescents aged 3 to 15 years suffering from the same disease. In patients treated according to the first and second programs, the 5-year survival amounted to 81.3 and 93.3%, respectively. The total number of lethal outcomes was 20.2 and 4.2%, respectively, during the whole observation period.
authors.forename: V E
authors.initials: VE
authors.lastname: Poliakov
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008297:Male; D011879:Radiotherapy Dosage; D013997:Time Factors
vernacular_title: Neposredstvennye i otdalennye rezul'taty kompleksnoĭ programmoĭ terapii limfogranulematoza (bolezni Khodzhkina) u deteĭ i podrostkov.