title: Xerophthalmia in Ethiopia: a nationwide ophthalmological, biochemical and anthropometric survey.
abstract: A total of 6636 children, aged from 6 months to 6 years and selected throughout the country using a multi-staged stratified sample design, were examined for signs of xerophthalmia. The concentrations of retinol and of beta-carotene were measured in 742 children, including those with xerophthalmia and every twentieth of the remaining children. Anthropometric measurements were made on 2909 of the children. Bitot's spots were seen in 1.0% of all children, with a higher prevalence in the pastoral (1.6%) and cropping (1.1%) agro-ecological zones than in the zones characterized by cash crops (0.4%) and 'ensete' (false banana, Ensete ventricosum) (0.0%). One case of corneal xerosis and 2 cases of corneal scar were also seen. Serum retinol levels were in the 'deficient' range (less than 0.35 mumol l-1) in 16% and 'low' (0.35-0.69 mumol l-1) in 44% of children. Serum retinol and clinical signs did not show any correlation with occupation and education of head of household, household size or anthropometric measurements. More stunting than wasting was observed, with peak prevalence of these signs of malnutrition being observed in the second year of life.
authors.affiliation: Ethiopian Nutrition Institute, Addis Ababa.
authors.forename: Z
authors.initials: Z
authors.lastname: Wolde-Gebriel
authors.forename: T
authors.initials: T
authors.lastname: Demeke
authors.forename: C E
authors.initials: CE
authors.lastname: West
mesh_terms: D000383:Agriculture; D000886:Anthropometry; D002338:Carotenoids / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009749:Nutrition Surveys; D009887:Ophthalmoscopy; D015995:Prevalence; D012111:Residence Characteristics; D012172:Retinaldehyde / Q000097:blood; D016036:Seroepidemiologic Studies; D014802:Vitamin A Deficiency / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D014985:Xerophthalmia / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D019207:beta Carotene
chemical_list: D019207:beta Carotene; D002338:Carotenoids; D012172:Retinaldehyde