Synthesis and in vitro antibacterial properties of 2-(3-bromo-5-isoxazolylideneamino-oxy)acetamido-beta-lactam derivatives.
The synthesis of new 2-(3-bromo-5-isoxazolylideneamino-oxy)acetic acids and their condensation derivatives with suitable beta-lactam nuclei is reported. Their antibacterial properties have been tested in vitro. An interesting activity against Gram-positive bacteria including beta-lactamase-producing microorganisms was found among the cephalosporanic acid derivatives.
Sala
A
A
Zambon Research Laboratories, Milano, Italy.
Chiarino
D
D
Napoletano
M
M
Albini
E
E
Carenzi
A
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002511:Cephalosporins / Q000138:chemical synthesis / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000201:enzymology; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000201:enzymology; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000138:chemical synthesis / Q000494:pharmacology; D001618:beta-Lactamases / Q000096:biosynthesis; D047090:beta-Lactams / Q000138:chemical synthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D007555:Isoxazoles; D010406:Penicillins; D047090:beta-Lactams; D001618:beta-Lactamases