title: Two new styryl lactones, 9-deoxygoniopypyrone and 7-epi-goniofufurone, from Goniothalamus giganteus.
abstract: Two new styryl lactones, 9-deoxygoniopypyrone [1] and 7-epi-goniofufurone [3], and a known styryl lactone, goniodiol [5], were isolated from the stem bark of Goniothalamus giganteus. The structures were elucidated by ir, ms, 1H-nmr, 13C-nmr, and 1H-1H COSY spectra; the relative configurations were determined by X-ray crystallographic analysis. Unlike goniopypyrone [2] and goniofufurone [4], neither of the new styryl lactones 1 and 3 showed significant bioactivities to human tumor cells. However, goniodiol [5] showed significant and selective cytotoxicity against human lung tumor cells (A-549).
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
authors.forename: X P
authors.initials: XP
authors.lastname: Fang
authors.forename: J E
authors.initials: JE
authors.lastname: Anderson
authors.forename: C J
authors.initials: CJ
authors.lastname: Chang
authors.forename: J L
authors.initials: JL
authors.lastname: McLaughlin
authors.forename: P E
authors.initials: PE
authors.lastname: Fanwick
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D001156:Artemia / Q000187:drug effects; D003461:Crystallography; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010944:Plants; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; C073078:9-deoxygoniopypyrone; C073080:7-goniofufurone