title: [Immunohistochemical studies of bronchial carcinoma using monoclonal antibody A63-C/A3].
abstract: An immunohistological study was undertaken, using paraffin sections of 22 cases of lung carcinoma and a number of reference tissue samples, to clear up the reactivity of A63-C/A63 monoclonal antibody (IgM) which was capable of identifying a carcinoma-associated carbohydrate antigen. Following neuraminidase pretreatment of those sections, positive response to the above antigen was produced by more than 90% of all bronchial carcinoma samples, notwithstanding the histological type involved (squamous-cell carcinoma or adenocarcinoma). Columnar epithelium of the bronchi, not involved in the neoplastic process gave a positive immunoreaction with the antibody A63-C/A3 in 64% of the cases.
authors.affiliation: Forschungsinstitut für Lungenkrankheiten und Tuberkulose, Berlin-Buch, BRD.
authors.forename: S
authors.initials: S
authors.lastname: Weber
authors.forename: L
authors.initials: L
authors.lastname: Reinhold-Richter
authors.forename: U
authors.initials: U
authors.lastname: Karsten
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology; D000911:Antibodies, Monoclonal; D002276:Carcinoid Tumor / Q000737:chemistry / Q000473:pathology; D002283:Carcinoma, Bronchogenic / Q000737:chemistry / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology*; D008297:Male; D009439:Neuraminidase / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D009439:Neuraminidase
vernacular_title: Immunhistochemische Untersuchung von Bronchialkarzinomen mit Hilfe des monoklonalen Antikörpers A63-C/A3.