[Mechanism of differential effect of low dose adaptogens on the functional activity of normal and transformed cellular elements in vitro].
Influence of water solutions of chemically pure adaptogen--synthetic analog of Rhodiola Rosea extract phenol composition (SAR) on functional activity of hemopoietic and tumor cells of mice with Ehrlich ascite cancer was studied in vitro. The periodical character of SAR effects was shown to be different for both types of cells, and at 1 x 10(-2) and 1 x 10(-26) M concentrations simultaneous stimulation of blood marrow cells colony-forming activity and inhibition of the latter in tumor elements was revealed. Essential changes of reactions of both cell types after adding the DNA-dependent RNA polymerase blocker Actinomycin D permit to suggest SAR effects to be connected with drug influence on the membrane RNA of the target cells.
Udintsev
S N
SN
Shakhov
V P
VP
Borovskoĭ
I G
IG
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D003114:Colony-Forming Units Assay; D003609:Dactinomycin / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014410:Tumor Stem Cell Assay
D010636:Phenols; D010936:Plant Extracts; D003609:Dactinomycin
K mekhanizmu differentsirovannogo vliianiia malykh doz adaptogenov na funktsional'nuiu aktivnost' normal'nykh i transformirovannykh kletochnykh élementov in vitro.