title: Regulation of IgE synthesis by cytokines.
abstract: Considerable progress has been made in our understanding of the mechanisms underlying regulation of human IgE synthesis. Interleukin-4 induces IgE production specifically, but costimulatory signals provided by T cells are required. Other cytokines modulate interleukin-4-induced IgE synthesis. The roles of T cells and cytokines in regulating IgE switching are discussed.
authors.affiliation: DNAX Research Institute, Palo Alto, California.
authors.forename: J E
authors.initials: JE
authors.lastname: de Vries
authors.forename: J F
authors.initials: JF
authors.lastname: Gauchat
authors.forename: G G
authors.initials: GG
authors.lastname: Aversa
authors.forename: J
authors.initials: J
authors.lastname: Punnonen
authors.forename: H
authors.initials: H
authors.lastname: Gascan
authors.forename: H
authors.initials: H
authors.lastname: Yssel
mesh_terms: D000916:Antibody Diversity / Q000235:genetics; D005786:Gene Expression Regulation; D005803:Genes, Immunoglobulin; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000235:genetics; D007134:Immunoglobulin Switch Region; D015847:Interleukin-4 / Q000096:biosynthesis / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015847:Interleukin-4; D007073:Immunoglobulin E