title: Concomitant Creutzfeldt-Jakob and Alzheimer diseases.
abstract: We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identified by Western blot analysis of brain extracts.
authors.affiliation: Department of Pathology, Columbia-Presbyterian Medical Center, New York, NY.
authors.forename: J M
authors.initials: JM
authors.lastname: Powers
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: L S
authors.initials: LS
authors.lastname: Hair
authors.forename: R J
authors.initials: RJ
authors.lastname: Kascsack
authors.forename: L D
authors.initials: LD
authors.lastname: Lewis
authors.forename: L A
authors.initials: LA
authors.lastname: Levy
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001284:Atrophy / Q000473:pathology; D015153:Blotting, Western; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001923:Brain Chemistry; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D014057:Tomography, X-Ray Computed
chemical_list: D016229:Amyloid beta-Peptides