title: Contribution of the known subcellular effects of anesthetics to their negative inotropic effect in intact myocardium.
abstract: The results of these studies suggest that halothane, in addition to its effect of reducing the trans-sarcolemmal Ca2+ influx, has a direct effect on the function of the sarcoplasmic reticulum by making the organelle leaky to Ca2+ and reducing the amount of Ca2+ stored. Isoflurane, on the other hand, does not appear to make the sarcoplasmic reticulum leaky to Ca2+. In fact, our observations suggest that isoflurane makes the sarcoplasmic reticulum less leaky to Ca2+. Halothane may enhance the reduction in the myofibrillar response to activator Ca2+ when the muscle fiber length is shortened. Thiopental appears to reduce the trans-sarcolemmal Ca2+ influx without reducing the amount of Ca2+ stored in the sarcoplasmic reticulum.
authors.affiliation: Department of Anesthesiology, University of Wisconsin, Madison 53792.
authors.forename: H
authors.initials: H
authors.lastname: Komai
authors.forename: B F
authors.initials: BF
authors.lastname: Rusy
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D006221:Halothane / Q000494:pharmacology; D066298:In Vitro Techniques; D007530:Isoflurane / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D009210:Myofibrils / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D012433:Ryanodine / Q000494:pharmacology; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism; D013347:Subcellular Fractions / Q000187:drug effects*
chemical_list: D000777:Anesthetics; D012433:Ryanodine; D007530:Isoflurane; D006221:Halothane