Doxorubicin storage in myocardial tissue of reserpine- and nicardipine-pretreated rats.
While reserpine and nicardipine pretreatment induced a more or less marked decrease in typical red-orange doxorubicin fluorescence in certain rat tissues, such as spleen, kidney and large intestine, the myocardial tissue (right atrium and left ventriculum) did not show any significant variations in nuclear doxorubicin storage. This different behaviour of cardiac tissue may be related to the well-known doxorubicin cardiotoxicity.
Soldani
P
P
Istituto di Anatomia Umana Normale, Facoltà di Medicina e Chirurgia, Università degli Studi di Pisa, Italy.
Pellegrini
A
A
Breschi
M C
MC
Natale
G
G
Paparelli
A
A
D000818:Animals; D004317:Doxorubicin / Q000378:metabolism*; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009529:Nicardipine / Q000494:pharmacology*; D011292:Premedication; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology*; D013154:Spleen / Q000378:metabolism
D004317:Doxorubicin; D012110:Reserpine; D009529:Nicardipine