[Penetration of cefixime in the anterior chamber of the human eye].
Penetration of cefixime in aqueous humor was investigated in 21 patients about to undergo elective cataract extraction. All subjects received a 400 mg oral dose. Aqueous humor was collected within 4, 6, 10 or 15 hours after the administration. Cefixime was measured by liquid chromatography. The concentration of cefixime in aqueous humor was below 0.05 mg/l in 17 patients. The highest level reached was 0.16 mg/l. In spite of lower minimal inhibitory concentrations than first generation oral cefalosporins, cefixime per os cannot be proposed for the treatment of postoperative ocular infections.
Tod
B
B
Centre Lamaze, Blanc-Mesnil.
Chaine
G
G
Oliary
J
J
Mezzanotte
F
F
Tod
M
M
Petitjean
O
O
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000378:metabolism; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D020682:Cefixime; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D002511:Cephalosporins / Q000493:pharmacokinetics; D006801:Humans; D008875:Middle Aged; D015503:Surgical Sponges
D000892:Anti-Infective Agents, Urinary; D002511:Cephalosporins; D020682:Cefixime; D002439:Cefotaxime
Pénétration du céfixime dans la chambre antérieure de l'oeil humain.