title: Diuretic profile of a novel loop diuretic torasemide in rats and dogs.
abstract: In the present study, the authors have examined the diuretic action of a novel loop diuretic torasemide and compared it to those of other diuretics, employing normal rats and dogs. Oral administration of torasemide elicited a dose-dependent increase in urine volume and electrolyte excretion, and elevated the urinary Na/K ratio in rats. These effects were more potent than those of the other diuretics furosemide, trichlormethiazide, indapamide and spironolactone. Moreover, torasemide exhibited a similar or higher urinary Na/K ratio than the combination of these diuretics and spironolactone. In a study employing anaesthetized dogs, i.v. injection of torasemide resulted in a higher urinary Na/K ratio in comparison to furosemide, in addition to potent and long-lasting diuretic activity.
authors.affiliation: Central Research Laboratory, Green Cross Corporation, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Uchida
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtaki
authors.forename: H
authors.initials: H
authors.lastname: Kido
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000758:Anesthesia; D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013148:Spironolactone / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*; D000077786:Torsemide
chemical_list: D004232:Diuretics; D013449:Sulfonamides; D013148:Spironolactone; D000077786:Torsemide