title: Ductal shunting and effective systemic blood flow following single dose surfactant treatment in the premature baboon with hyaline membrane disease.
abstract: We studied the hemodynamic effects of using natural surfactant in premature baboons with hyaline membrane disease (HMD). Study animals (n = 5) received a single dose of surfactant immediately after delivery and control animals (n = 8) did not. Using microspheres at 3, 8, and 23 h we found no significant differences in left ventricular output, effective systemic flow, systemic-to-pulmonary patent ductus arteriosus (PDA) shunting, or in cerebral or renal organ blood flow. However, both groups had large PDA shunts (fraction of LVO to lungs greater than 0.40-0.55 at 3 and 8 h) resulting in low systemic perfusion (less than 80 ml/min/kg). Single dose surfactant did not improve the myocardial dysfunction and low cerebral and renal blood flow which occur during treatment for HMD.
authors.affiliation: Department of Pediatrics, Fitzsimons Army Medical Center, Aurora, Col.
authors.forename: J P
authors.initials: JP
authors.lastname: Kinsella
authors.forename: D R
authors.initials: DR
authors.lastname: Gerstmann
authors.forename: A K
authors.initials: AK
authors.lastname: Gong
authors.forename: A F
authors.initials: AF
authors.lastname: Taylor
authors.forename: R A
authors.initials: RA
authors.lastname: deLemos
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000098:blood supply; D004195:Disease Models, Animal; D004374:Ductus Arteriosus, Patent / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006819:Hyaline Membrane Disease / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D007668:Kidney / Q000098:blood supply; D008863:Microspheres; D010215:Papio; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012121:Respiration, Artificial; D012129:Respiratory Function Tests
chemical_list: D011663:Pulmonary Surfactants