Magnetic resonance imaging of lipid deposits in human atheroma via a stimulated-echo diffusion-weighted technique.
NMR images of subintimal lipid deposits within the vessel walls of atherosclerotic human aortas were obtained at 37 and 27 degrees C at 4.7 T. A combination of a stimulated-echo and pulsed-field gradients was used for suppressing the mobile tissue water relative to the less mobile tissue lipids. At 27 degrees C there was also a substantial reduction of the subintimal lipid signal intensity, which is consistent with the characteristic phase transition of cholesteryl esters in human atheroma. These results represent the first direct detection of lipid deposits in nonprotruding atherosclerotic lesions with NMR imaging.
Altbach
M I
MI
Department of Chemistry, University of Arizona, Tucson 85721.
Mattingly
M A
MA
Brown
M F
MF
Gmitro
A F
AF
D001011:Aorta / Q000473:pathology; D001018:Aortic Diseases / Q000175:diagnosis*; D001161:Arteriosclerosis / Q000175:diagnosis*; D006801:Humans; D008055:Lipids / Q000032:analysis; D008279:Magnetic Resonance Imaging / Q000379:methods*
D008055:Lipids