[Mild forms of multi-infarct dementia: effectiveness of cerebrolysin].
The randomized double-blind placebo-controlled study of the effectiveness of cerebrolysin in a mild form of multi-infarct dementia was carried out. Sixty patients were divided in two equal groups differing significantly at the beginning of the study by none of the compared parameters. They received for 28 days daily drop intravenous doses of cerebrolysin (15 ml of the drug in 200 ml of a 0.85% NaCl solution: 10 ml in the morning and 5 ml in the evening) or placebo in the same amount of the solution. The control of the therapy effectiveness was instituted clinically (by means of a special scale), electroencephalographically, and using the psychological test of Arnold-Kohlmann and the test for response time. The study found a significant improvement of the memory (p-0.01), abstract thinking and time of reaction in the patients on cerebrolysin, confirmed also by the EEG-mapping. It is believed advisable to use the drug cerebrolysin in mild forms of multi-infarct dementia.
Vereshchagin
N V
NV
Nekrasova
E M
EM
Lebedeva
N V
NV
Suslina
Z A
ZA
Solov'ev
O I
OI
Piradov
M A
MA
Altunina
M N
MN
D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain; D015161:Dementia, Multi-Infarct / Q000188:drug therapy*; D004311:Double-Blind Method; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests
D000596:Amino Acids; C006952:cerebrolysin
Legkie formy mul'tiinfarktnoĭ dementsii: éffektivnost' tserebrolizina.