title: Replacement of chloride deficit by use of 1.8% NaCl to correct experimentally induced hypochloremic metabolic alkalosis in sheep.
abstract: Five adult 40- to 50-kg female sheep were surgically fitted with a reentrant cannulae placed in the proximal part of the duodenum just distal to the pylorus. By diversion of abomasal outflow, this model has been shown to produce hypochloremic metabolic alkalosis accompanied by dehydration, hypokalemia, and hyponatremia. Each sheep was subjected to 3 separate, 12-hour IV treatment trials, in each case preceded by a control period of 48 hours, and a diversion period of 36 to 96 hours, during which a hypochloremic (Cl- less than or equal to 60 +/- 2 mEq/L) metabolic alkalosis with hypokalemia and hyponatremia was produced. Treatment 1, consisting of 6 L of isotonic Na gluconate, was designed to replace volume without replenishing the Cl-1 deficit. Although hydration improved, plasma Cl- decreased further, and the sheep became increasingly weak and depressed. Treatment 2, consisting of 2 L of 1.8% NaCl, was designed to replace the Cl- deficit without replacing total volume. Plasma Na+ and Cl- concentrations returned to normal during the 12 hours of treatment; acid-base balance and plasma K+ concentrations returned to normal within 36 hours of treatment. During treatment 3 (control, no treatment), measured metabolic values changed minimally. We concluded that the IV replacement of Cl- without K+ is effective in the correction of experimentally induced hypochloremic metabolic alkalosis in sheep.
authors.affiliation: Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
authors.forename: S L
authors.initials: SL
authors.lastname: Fubini
authors.forename: D F
authors.initials: DF
authors.lastname: Smith
authors.forename: Y T
authors.initials: YT
authors.lastname: Grohn
authors.forename: S A
authors.initials: SA
authors.lastname: Levine
authors.forename: D M
authors.initials: DM
authors.lastname: Deuel
mesh_terms: D000471:Alkalosis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001835:Body Weight; D002712:Chlorides / Q000097:blood*; D005260:Female; D005942:Gluconates / Q000627:therapeutic use; D006863:Hydrogen-Ion Concentration; D011188:Potassium / Q000097:blood; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D012964:Sodium / Q000097:blood; D012965:Sodium Chloride / Q000627:therapeutic use*
chemical_list: D001639:Bicarbonates; D002712:Chlorides; D005942:Gluconates; D012965:Sodium Chloride; D012964:Sodium; C030691:gluconic acid; D011188:Potassium