Antifertility effects of sulfapyridine on male hamsters.
Sulfapyridine was administered to mature male golden hamsters either by impregnation in feed pellets, or by subcutaneous injection as a solution in dimethylsulfoxide. The average litter size for control males was 8.3 +/- 3.3 (n = 13) vs. 4.2 +/- 2.7 (n = 11) for sulfapyridine-fed treated animals. Histology of the testis and epididymis was normal and sperm were normal in morphology and motility. Subcutaneous injection of sulfapyridine caused much more dramatic inhibition of male fertility than was achieved by feeding the drug. Sulfapyridine (750 mg/kg body weight in 0.2 ml DMSO) injected subcutaneously for 60 days was effective in reducing testis size and sperm quality. Histology of testes showed spermatogenic arrest at young spermatids. Two classes of animals were found in both sulfapyridine-fed and -injected treatment groups. One class was relatively resistant to the antifertility effects of the drugs. This difference may reflect differing abilities of the animals to convert sulfapyridine to an active form or to excrete its metabolites.
Weissenberg
R
R
Institute of Endocrinology, Sheba Medical Center, Tel HaShomer, Israel.
Pholpramool
C
C
Lewin
L M
LM
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006224:Cricetinae; D004032:Diet; D004822:Epididymis / Q000033:anatomy & histology / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007279:Injections, Subcutaneous; D008098:Litter Size / Q000187:drug effects; D008297:Male; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D012016:Reference Values; D012669:Seminal Vesicles / Q000033:anatomy & histology / Q000187:drug effects*; D013427:Sulfapyridine / Q000008:administration & dosage / Q000494:pharmacology* / Q000652:urine; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects*
D013427:Sulfapyridine