title: Repletion and depletion of vitamin E in gastroduodenal mucosa.
abstract: Male rats were used to assess the effect of fasting and depletion and repletion rates on the levels of vitamin E in the liver and in mucosa from the fundus, antrum, and duodenum. Fasting for 24 h did not produce a significant decrease in vitamin E content in gastroduodenal mucosa. Feeding rats a diet low in vitamin E content for 10 weeks produced very low levels of the vitamin in all the tissues studied (below 2.4 micrograms/g tissue). Feeding rats a diet high in vitamin E content for 10 weeks produced high levels of vitamin E in the liver (64.5 micrograms/g) and in fundic (47.5), antral (36.9), and duodenal (24.5) mucosa. Calculated rates of depletion (microgram/g tissue/day) were very low in fundic and antral mucosa (0.2-0.7); duodenal mucosa (4.2) and liver (12.2) were the highest. Rates of repletion (microgram/g tissue/day) were lower in the antrum (1.2) and fundus (2.6); duodenal (4.2) and liver (7.6) were the highest. The findings of this study indicate that fasting or short-term dietary manipulation did not substantially change the vitamin E content of the gastroduodenal mucosa.
authors.affiliation: Bureau of Human Prescription Drugs, Health and Welfare Canada, Ottawa, Ontario.
authors.forename: G
authors.initials: G
authors.lastname: Zaror-Behrens
authors.forename: W A
authors.initials: WA
authors.lastname: Behrens
authors.forename: R
authors.initials: R
authors.lastname: Madère
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004386:Duodenum / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005215:Fasting / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D014810:Vitamin E