Effect of sho-saiko-to (TJ-9, Japanese herbal medicine) on estradiol receptors in the cytosol of hepatic sinusoidal endothelial cells.
We first confirmed the presence of estradiol receptors in the cytosol of rat hepatic sinusoidal endothelial cells and then studied the effects of Sho-saiko-to (TJ-9) on the level of these cytosol estradiol receptors. As a result, we found that estradiol receptors are present in the cytosol of hepatic sinusoidal endothelial cells from rats. Moreover, when these cells were incubated with TJ-9, the level of cytosol estradiol receptors increased. These results suggested that TJ-9 acts on hepatic sinusoidal endothelial cells to increase the level of estradiol receptors, thereby affecting the immune reactions in the liver.
Mizoguchi
Y
Y
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Ichikawa
Y
Y
Kobayashi
K
K
Morisawa
S
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002478:Cells, Cultured; D003600:Cytosol / Q000737:chemistry* / Q000648:ultrastructure; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004727:Endothelium / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D007564:Japan; D008099:Liver / Q000166:cytology* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D011959:Receptors, Estradiol / Q000032:analysis* / Q000187:drug effects* / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D011959:Receptors, Estradiol; C018142:saiko-keishi-to