title: On kynureninase activity.
abstract: 1) In Mg-deficient rats, kynureninase activity is decreased. 2) p-Hydroxyphenylpyruvate inhibits kynureninase activity. 3) -SH groups in the apoenzyme of kynureninase play a very important role in the enzymatic reaction. 4) 3-Hydroxykynurenine may be a very important regulative metabolite in the 3-hydroxykynurenine----xanthurenic acid pathway.
authors.affiliation: Department of Biochemistry, Aichi Medical University Nagakute, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shibata
authors.forename: F
authors.initials: F
authors.lastname: Takeuchi
authors.forename: R
authors.initials: R
authors.lastname: Tsubouchi
authors.forename: M
authors.initials: M
authors.lastname: Haneda
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: M
authors.initials: M
authors.lastname: Nakatsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Nisimoto
authors.forename: T
authors.initials: T
authors.lastname: Tamai
authors.forename: S
authors.initials: S
authors.lastname: Nomura
authors.forename: H
authors.initials: H
authors.lastname: Fujimoto
mesh_terms: D000818:Animals; D001051:Apoenzymes / Q000378:metabolism; D052160:Benzothiazoles; D003545:Cysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D004228:Dithionitrobenzoic Acid / Q000494:pharmacology; D004229:Dithiothreitol / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006867:Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007737:Kynurenine / Q000031:analogs & derivatives* / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008274:Magnesium / Q000378:metabolism; D008297:Male; D010667:Phenylpyruvic Acids / Q000494:pharmacology; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan / Q000378:metabolism; D014443:Tyrosine / Q000494:pharmacology; D014977:Xanthurenates / Q000378:metabolism*
chemical_list: D001051:Apoenzymes; D052160:Benzothiazoles; D010667:Phenylpyruvic Acids; D014977:Xanthurenates; C010590:4-hydroxyphenylpyruvic acid; C005045:3-hydroxykynurenine; D007737:Kynurenine; C034680:S-(2-benzothiazolyl)cysteine; D014443:Tyrosine; C028330:xanthurenic acid; D011732:Pyridoxal Phosphate; D014364:Tryptophan; D004228:Dithionitrobenzoic Acid; D006867:Hydrolases; C021480:kynureninase; D008274:Magnesium; D003545:Cysteine; D004229:Dithiothreitol