title: No female preponderance in juvenile periodontitis after correction for ascertainment bias.
abstract: Juvenile periodontitis (JP) is generally recognized to exist in 2 clinical forms: localized and generalized. Historically, females have been reported to be affected by both forms of JP at rates of 2 to 10 times greater than males. However, evidence suggests that females are more likely than males to seek dental care. If this is true, females will be diagnosed with JP more often than males even if juvenile periodontitis is equally prevalent among males and females in the general population. Thus, previous reports of a female predominance for JP may simply reflect this selection bias. The purpose of this study was to test our hypothesis that juvenile periodontitis occurs with equal frequency in males and females after correcting for selection bias. Twenty-four juvenile periodontitis probands were ascertained from the VCU/MCV dental clinics. The families of these individuals were examined to determine the relative prevalence of JP among male and female relatives of these probands. Our results indicate that while females are 3 times more likely than males to be initially ascertained as juvenile periodontitis probands, among relatives of probands the proportion of affected males and females is equal.
authors.affiliation: Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond.
authors.forename: T C
authors.initials: TC
authors.lastname: Hart
authors.forename: M L
authors.initials: ML
authors.lastname: Marazita
authors.forename: H A
authors.initials: HA
authors.lastname: Schenkein
authors.forename: C N
authors.initials: CN
authors.lastname: Brooks
authors.forename: J G
authors.initials: JG
authors.lastname: Gunsolley
authors.forename: S R
authors.initials: SR
authors.lastname: Diehl
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000453:epidemiology* / Q000235:genetics; D000704:Analysis of Variance; D015982:Bias; D002648:Child; D005260:Female; D006801:Humans; D007575:Jaw, Edentulous / Q000453:epidemiology; D008297:Male; D010518:Periodontitis / Q000453:epidemiology / Q000235:genetics; D012044:Regression Analysis; D012737:Sex Factors; D014768:Virginia / Q000453:epidemiology