title: Pharmacokinetics and bioavailability of famotidine in 10 Chinese healthy volunteers.
abstract: The pharmacokinetics and bioavailability of famotidine were investigated by HPLC method in 10 Chinese healthy volunteers. Data obtained from HPLC were analysed automatically using a MCPKP program on microcomputer. Linear pharmacokinetics were observed following either iv or po administration. After 20 mg iv, plasma levels declined biexponentially with an initial T1/2 of 0.3 +/- 0.2 h and terminal T1/2 of 3.5 +/- 0.8 h. The plasma elimination T1/2 following po administration were 3.4 +/- 0.7 h and 3.5 +/- 0.5 h for capsules and tablets respectively. Oral absorption was incomplete. The absolute bioavailabilities were 38 +/- 10% for capsules and 43 +/- 11% for tablets. Renal excretion was the major route of elimination. About 72% of the dose were recovered as unchanged famotidine in urine. Mean renal and plasma clearance were 416 and 541 ml.min-1 respectively.
authors.affiliation: Department of Clinical Pharmacology, Changhai Hospital, China.
authors.forename: S
authors.initials: S
authors.lastname: Gao
authors.forename: G L
authors.initials: GL
authors.lastname: Liu
authors.forename: S X
authors.initials: SX
authors.lastname: Wang
authors.forename: X H
authors.initials: XH
authors.lastname: Gao
mesh_terms: D000328:Adult; D001682:Biological Availability; D002214:Capsules; D015738:Famotidine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D013607:Tablets
chemical_list: D002214:Capsules; D013607:Tablets; D015738:Famotidine