Effects of cicletanine on vasoactive systems in conscious sinoaortic-denervated dogs.
The present study investigates the antihypertensive action of cicletanine, a new antihypertensive compound with diuretic properties (or placebo), on vasopressor (catecholamines, renin-aldosterone) as well as vasodepressor (prostaglandins, kallikrein-kinin) systems in conscious chronic sinoaortic denervated (SAD) dogs. Cicletanine (10 mg/kg twice a day, per os, for one month) lowered blood pressure and heart rate. The antihypertensive action does not involve an effect on sympathetic tone (since plasma catecholamine levels were unmodified) or on plasma aldosterone levels. By contrast, urinary 6 keto PGF1 or PGE2 levels and kallikrein activity were enhanced. This result indicates that the antihypertensive effect of cicletanine is associated with a stimulation of potential vasodepressor systems (such as prostaglandins or kinins).
Damase-Michel
C
C
Laboratoire de pharmacologie médicale et clinique, INSERM U 317, Faculté de médecine, Toulouse, France.
Girolami
J P
JP
Bascands
J L
JL
Tran
M A
MA
Moatti
J P
JP
Pecher
C
C
Berthet
P
P
Tarrade
T
T
Montastruc
J L
JL
D000450:Aldosterone / Q000097:blood; D000595:Amino Acid Sequence; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000097:blood; D003404:Creatinine / Q000097:blood; D004232:Diuretics / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D007610:Kallikreins / Q000652:urine; D008297:Male; D008969:Molecular Sequence Data; D011188:Potassium / Q000097:blood / Q000652:urine; D011453:Prostaglandins / Q000652:urine; D011725:Pyridines; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine; D014508:Urea / Q000097:blood
D000959:Antihypertensive Agents; D001786:Blood Glucose; D002395:Catecholamines; D004232:Diuretics; D011453:Prostaglandins; D011725:Pyridines; D000450:Aldosterone; D014508:Urea; D012964:Sodium; D003404:Creatinine; C038068:cicletanine; D007610:Kallikreins; D012083:Renin; D011188:Potassium