Vanadate stimulates ornithine decarboxylase activity in C3H/10T1/2 cells.
Ornithine decarboxylase (ODC) activity of C3H/10T1/2 cells reflects their response to conflicting actions of many tumor promoters and tumor suppressors. In cultured C3H/10T1/2 cells, addition of vanadate (50 nM) increased ODC activity. Over the range 0.05-5 microM, vanadate increased ODC levels in a dose dependent manner to 11 times control levels. The presence of retinoic acid (5 microM) or the absence of fetal calf serum blocked the stimulation by vanadate.
Davison
A J
AJ
Bioenergetics Research Laboratory, School of Kinesiology, Faculty of Applied Sciences Simon Fraser University, Burnaby B.C., Canada.
Stern
A
A
Fatur
D J
DJ
Tsang
S S
SS
D000818:Animals; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008809:Mice, Inbred C3H; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D014212:Tretinoin / Q000494:pharmacology; D014638:Vanadates / Q000494:pharmacology*
D014638:Vanadates; D014212:Tretinoin; D009955:Ornithine Decarboxylase