[Improvement of chronic regionally impaired myocardial function immediately after coronary angioplasty].
The effect of PTCA on chronically impaired, regional wall motion was studied in 40 patients with stable angina and stenoses in the left anterior descending artery. Left-ventricular angiograms were obtained before, 15 min after PTCA and, additionally, in eight patients 15 +/- 5 weeks after PTCA. Left-ventricular ejection fraction and regional myocardial function were assessed by the centerline method. Patients with no (n = 18) or non-Q-wave (n = 12) infarction were compared to patients with Q-wave infarction (n = 10). After PTCA, ejection fraction increased from 54 +/- 8% to 59 +/- 8% (p less than 0.05) and regional function improved significantly (maximal standard deviation before PTCA: 2.8 +/- 0.8; after PTCA: 1.9 +/- 0.9- segments below the first standard deviation before PTCA: 31 +/- 16; after PTCA: 19 +/- 17). The improvements were found in patients with no or non-Q-wave infarction. The benefit on regional function was unchanged at follow-up.


CONCLUSIONS
PTCA reduced chronic regional myocardial dysfunction in 78% of the patients with stable angina within 15 min. Reversible myocardial dysfunction is most likely related to hibernating myocardium.
Schuchert
A
A
Abteilung Kardiologie, Universitäts-Krankenhaus Eppendorf, Hamburg.
Hamm
C W
CW
Reimers
J
J
Middendorf
N
N
Bleifeld
W
W
D000368:Aged; D000787:Angina Pectoris / Q000503:physiopathology* / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D002302:Cardiac Output / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology* / Q000628:therapy*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy; D011446:Prospective Studies; D016277:Ventricular Function, Left / Q000502:physiology
Verbesserung der chronisch regional eingeschränkten Myokardfunktion sofort nach Koronarangioplastie.