[The pharmacokinetic characteristics of the new psychotropic preparation with nootropic action ONK-10 in the progeny of alcoholized animals].
There were found significant differences in the pharmacokinetics of a new psychotropic drug with nootropic action ONC-10 following a long-term administration to the offspring of the intact animals as compared with the pharmacokinetics after a single administration: an increase of the drug content in plasma with a simultaneous decrease of clearance and the volume of distribution. A long-term administration of ONC-10 to the offspring of the alcoholized animals led to a decrease of the plasma drug level that was related to not only an increase of the constant of elimination and clearance of the drug but also an enhancement of the processes of its biotransformation and the appearance of the main metabolite.
Boĭko
S S
SS
Zherdev
V P
VP
D000437:Alcoholism / Q000097:blood*; D000818:Animals; D002853:Chromatography, Liquid; D005260:Female; D005971:Glutamates / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D013997:Time Factors
D005971:Glutamates; D009539:Nicotinic Acids; D011619:Psychotropic Drugs; C066295:nooglutil
Osobennosti farmakokinetiki novogo psikhotropnogo preparata s nootropnym deĭstviem ONK-10 u potomstva alkogolizirovannykh zhivotnykh.