title: Acute radiation effects on saliva composition in rats with different vitamin A levels in serum.
abstract: Irradiation of the head and neck often causes loss of salivary gland function which may lead to severe oral discomfort. The effects of a single dose of 25 Gy given to rats with different serum levels of vitamin A were studied. The salivary secretion rate as well as concentrations of protein, hexosamine, amylase and electrolytes, and the activities of two antibacterial glycoproteins were measured. At an adequate level of vitamin A in the diet, irradiation significantly reduced whole saliva secretion rate, and decreased the concentration of salivary sodium, calcium and hexosamine as well as the activity of a glycoprotein agglutinating a serotype c strain of S. mutans. Peroxidase, amylase and potassium were not significantly affected. The reductions seen at an adequate level of vitamin A were not reduced by supplementation of excess dietary retinol. The damage caused by irradiation was enhanced by vitamin A deficiency as seen in the reduced protein and hexosamine concentrations.
authors.affiliation: Department of Cariology, University of Umeå, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Funegård
authors.forename: I
authors.initials: I
authors.lastname: Johansson
authors.forename: L
authors.initials: L
authors.lastname: Franzén
authors.forename: T
authors.initials: T
authors.lastname: Ericson
mesh_terms: D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D006595:Hexosamines / Q000032:analysis; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects*; D012469:Salivary Glands / Q000528:radiation effects*; D014801:Vitamin A / Q000008:administration & dosage*; D014802:Vitamin A Deficiency / Q000097:blood / Q000150:complications*
chemical_list: D006595:Hexosamines; D014801:Vitamin A