Interleukin 1 production by monocytic leukemia cells and its possible role in coagulation abnormalities.
Interleukin 1 (IL-1) production by leukemic cells was studied in 16 patients with myelocytic or monocytic leukemia. Leukemic cells from the patients with monocytic leukemia showed higher IL-1 production than those with myelocytic leukemia. Subclinical coagulation abnormalities were observed more frequently in patients with higher IL-1 producing monocytic leukemia. It is suggested that IL-1 from leukemic cells might play important roles in the establishment of these clinical features. Such observations might be of value in the understanding of the pathophysiology of leukemia-associated paraneoplastic phenomena.
Furukawa
Y
Y
Division of Hemopoiesis, Jichi Medical School, Tochigi, Japan.
Ohta
M
M
Miura
Y
Y
Saito
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000502:physiology; D007948:Leukemia, Monocytic, Acute / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism; D015477:Leukemia, Myelomonocytic, Chronic / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014407:Tumor Cells, Cultured / Q000378:metabolism
D007375:Interleukin-1