[Impregnation and liberation of nicotine with hydrogen copolymer discs].
Reticulated copolymers with products N-vinyl-2 pyrrolidone (NVP), hydroxy-2 ethyl (HEMA) and methyl methacrylate (MMA) were realized in disc form. Nicotine was used as active principle. On these discs the following study was carried out: permeation, percentage of liquid absorbed, texture, as well as nicotine release kinetics. A 2-variable (NVP and HEMA/MMA), 5-level experimental plan has enabled the outlining of the significant differences on the action of these parameters. The release kinetics show particularly that these discs behave as forms of prolonged released and that the released quantities are sufficient to envisage the use of these reticulated copolymers within the framework of a transdermal system.
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Laboratoire de Pharmacie Galénique, Faculté des Sciences Pharmaceutiques, Toulouse.
Laurent
J L
JL
Rodriguez
F
F
Michaud
P
P
D000279:Administration, Cutaneous; D002626:Chemistry, Pharmaceutical; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D009538:Nicotine / Q000008:administration & dosage / Q000737:chemistry*; D011092:Polyethylene Glycols
D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D009538:Nicotine
Imprégnation et libération de nicotine à partir de disques de copolymère hydrogel réticulé.