[The combined therapy of stage-II lymphogranulomatosis: the effect of splenectomy and the time period for achieving full remission on treatment efficacy].
In 1982-1986, 72 patients with stage II lymphogranulomatosis received combined treatment according to the following program: 3 cycles of polychemotherapy in accordance with the CVPP scheme plus radiation of all the lymphatic collectors above the diaphragm up to the total radiation dose 35 Gy plus 3 cycles according to the CVPP. Splenectomy was provided to 45 patients; spleen impairment was revealed in 13. The median observation period reached 67 months. Both short- and long-term results of the treatment were analyzed. Neither splenectomy nor specific impairment thereof exerted any effect on the treatment results of this patients' group. The predominance of a number of "favourable" prognostic factors in splenectomized patients produced no effect on the treatment efficacy. It is concluded that in this patients' group, splenectomy is not advisable. A significant relationship was discovered between both survival and duration of the relapse-free course and the times of complete remission attainment. In patients, in whom complete remission was ascertained after 3 cycles of polychemotherapy and before radiotherapy onset, the 7-year survival amounted to 100% whereas the 7-year relapse-free course was recorded in 98% of cases, which is significantly higher than in patients, in whom only partial remission was attained by that time--78 and 68%, respectively (p less than 0.05).
Demina
E A
EA
Kondrat'eva
N F
NF
Pirogova
N A
NA
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006689:Hodgkin Disease / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage; D009367:Neoplasm Staging; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D012008:Recurrence; D012074:Remission Induction; D013156:Splenectomy; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage
D011344:Procarbazine; D014747:Vinblastine; D008130:Lomustine; D011241:Prednisone
Kombinirovannaia terapiia limfogranulematoza II stadii: vliianie splenéktomii i srokov dostizheniia polnoĭ remissii na éffektivnost' lecheniia.