Imidazolidin-2-one prostaglandin analogues.
The 5-desoxy analogue of BW245C, imidazolidin-2-one 3, has been synthesized by reduction of the N-benzyl hydantoin derivative 6. Compound 3 was found to be approximately equipotent with BW245C as an inhibitor of platelet aggregation and this result indicates that the 5-keto group of BW245C is not essential for platelet inhibitory activity.
Barraclough
P
P
Department of Medicinal Chemistry, Wellcome Research Laboratories, Beckenham, Kent.
Jackson
W P
WP
Harris
C J
CJ
D003510:Cyclohexanes / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006827:Hydantoins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis; D011465:Prostaglandins, Synthetic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D003510:Cyclohexanes; D006827:Hydantoins; D007093:Imidazoles; D010975:Platelet Aggregation Inhibitors; D011465:Prostaglandins, Synthetic; C030669:BW 245C; C072612:5-(6-carboxyhexyl)-1-(3-cyclohexane-3-hydroxypropyl)-5-deoxyhydantoin