Interplay of microbe and major histocompatibility complex: a family study.
We describe a 24-year-old man who developed reactive arthritis (ReA) after a dysenteric illness caused by Salmonella hadar. Serologic tests suggested recent exposure of family members to Salmonella. All members of the family were HLA-B27 positive, but no other family member developed acute ReA, although 2 of them had clinical evidence of previously existing B27 associated arthritis.
Thomson
G T
GT
Department of Medicine, University of Toronto, Canada.
Rajanayagam
C
C
Chiu
B
B
Thorne
C
C
Falk
J
J
Inman
R D
RD
D000328:Adult; D001170:Arthritis, Infectious / Q000235:genetics; D003429:Cross Reactions; D015235:HLA-B Antigens / Q000032:analysis; D015796:HLA-B27 Antigen / Q000032:analysis / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008285:Major Histocompatibility Complex; D008297:Male; D010375:Pedigree; D010641:Phenotype; D000091402:Prohibitins; D012480:Salmonella Infections / Q000276:immunology
D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; C081918:HLA-B60 antigen; D007136:Immunoglobulins; C000717331:PHB2 protein, human; D000091402:Prohibitins