[Effects of alminoprofen on sodium urate crystal-induced inflammation].
Effects of alminoprofen (AP), a non-steroidal anti-inflammatory agent, were investigated using several experimental gouty models. AP (3-30 mg/kg, p.o.) dose-dependently inhibited urate crystal-induced rat paw edema. AP (3-30 mg/kg, p.o.) inhibited the accumulation of exudate and decreased the total counts of leukocytes and the amount of PGE2 in a dose-dependent manner in sodium urate crystal-induced pleuritic rats. AP (0.3-10 mg/kg, p.o.) showed a dose-related analgesic activity on the pain response in sodium urate crystal-induced arthritic rats. AP (10(-5)-10(-3)M) inhibited the sodium urate crystal-induced beta-glucuronidase release from guinea pig neutrophils at more than 10(-4) M. AP (10(-5)-10(-3)M) did not inhibit the sodium urate crystal-induced production of O2- from guinea-pig neutrophils. AP (10(-6)-10(-4) M) inhibited dose-dependently the chemotaxis of leukocytes induced by chemotactic factors from guinea pig neutrophils stimulated with sodium urate crystals. AP (10(-6)-10(-4) M) inhibited the sodium urate crystal-induced production of PGE2 from rat peritoneal leukocytes in a dose-related manner. These results suggest that AP has a potent anti-inflammatory and analgesic activity in sodium urate crystal-induced inflammations, and these effects are exerted through its combined inhibitions of PGE2 synthesis, leukocyte chemotaxis and lysosomal enzyme release.
Maeda
E
E
Pharmaceutical Research Laboratories, Fujirebio, Inc., Tokyo, Japan.
Hujiyoshi
T
T
Uematsu
T
T
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003864:Depression, Chemical; D015232:Dinoprostone / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals; D005966:Glucuronidase / Q000378:metabolism; D006073:Gout / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D006168:Guinea Pigs; D008297:Male; D009504:Neutrophils / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism; D011422:Propionates / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014527:Uric Acid
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005609:Free Radicals; D010545:Peroxides; D011422:Propionates; C027953:alminoprofen; D014527:Uric Acid; D005966:Glucuronidase; D015232:Dinoprostone