Interethnic differences in drug glucuronidation: a comparison of paracetamol metabolism in Caucasians and Chinese.
Paracetamol disposition following a single oral 1 g dose of the drug was compared in groups (n = 12) of healthy young adult male Caucasians and Chinese. There was no difference between the groups in terms of paracetamol oral clearance, elimination half-life, or partial metabolic (glucuronidation, sulphation, oxidation) and renal clearances. The results demonstrate that drug glucuronidation is not universally impaired in Chinese and, together with previously published data, that paracetamol glucuronidation is minimally affected by race.
Osborne
N J
NJ
Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, Adelaide, South Australia.
Tonkin
A L
AL
Miners
J O
JO
D000082:Acetaminophen / Q000378:metabolism* / Q000493:pharmacokinetics; D000284:Administration, Oral; D000328:Adult; D044466:Asian People; D002681:China / Q000208:ethnology; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D013021:South Australia; D044465:White People
D000082:Acetaminophen