[Expression of blood group antigens(BGA) in esophageal carcinoma and its prognostic significance].
Five monoclonal antibodies directed against BGA of ABH and Lewis systems and sensitive immunohistochemical SABC method were used to study the expression of these antigens and analyze its significance in prognosis. The results showed: 1. The normal esophageal mucosa in most cases expressed positive BGA; 2. BGA were deleted or lost in most esophageal carcinomas, and the incompatibility of antigens and precursor accumulation were also found. 3. Expression of three or more BGA simultaneously in the same specimen might indicate better prognosis than those which expressed less than two BGA. Incompatibility of antigens also had prognostic significance.
Zhang
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Department of the First Internal Medicine, Hebei Provincial, Hospital, Shijiazhang.
D000017:ABO Blood-Group System / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D004938:Esophageal Neoplasms / Q000276:immunology*; D006801:Humans; D007519:Isoantigens / Q000032:analysis*; D007983:Lewis Blood Group Antigens / Q000276:immunology; D011379:Prognosis
D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D007519:Isoantigens; D007983:Lewis Blood Group Antigens