[Significance of pharmacokinetic parameters for effective drug therapy in house and domestic animals].
Aspects of pharmacokinetics (absorption, distribution, metabolism and excretion) and pharmacokinetic parameters (half-life time, elimination time, volume of distribution and bioavailability) are discussed. Treatment with food or drinking water demands additionally considerations to obtain a suitable drug level in the organism. Age- and sickness-dependent variations cause important changes of pharmacokinetic parameters. For an efficacious therapy, pharmacokinetic considerations are essential.
Kietzmann
M
M
Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztlichen Hochschule Hannover.
Löscher
W
W
D000818:Animals; D000829:Animals, Domestic / Q000097:blood*; D004358:Drug Therapy / Q000662:veterinary*; D008657:Metabolic Clearance Rate / Q000502:physiology; D010599:Pharmacokinetics
Bedeutung pharmakokinetischer Parameter für eine effektive Arzneimitteltherapie bei Haus- und Nutztieren.