title: Cyclodextrin sulfates: characterization as polydisperse and amorphous mixtures.
abstract: Alpha- and beta-cyclodextrins and their hydroxypropyl derivatives were converted by the reaction with chlorosulfonic acid in pyridine to the corresponding sulfates. Cyclodextrin sulfates were shown by fast-atom bombardment mass spectrometry (negative ion mode, triethanolamine matrix) to be mixtures with nearly symmetrical distributions of degree of substitution by sulfate groups and by powder X-ray diffraction to be amorphous. Thus, in these aspects, cyclodextrin sulfates are similar to the potent drug solubilizers hydroxypropylcyclodextrins.
authors.affiliation: NIA/GRC, National Institutes of Health, Baltimore, Maryland 21224.
authors.forename: J
authors.initials: J
authors.lastname: Pitha
authors.forename: L M
authors.initials: LM
authors.lastname: Mallis
authors.forename: D J
authors.initials: DJ
authors.lastname: Lamb
authors.forename: T
authors.initials: T
authors.lastname: Irie
authors.forename: K
authors.initials: K
authors.lastname: Uekama
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D013058:Mass Spectrometry; D012995:Solubility
chemical_list: D003505:Cyclodextrins