title: [Evaluation of the effectiveness of monotherapy in the treatment of epilepsy].
abstract: On 44 patients undergoing monotherapy, with total plasma levels of drug therapeutic range, 33 had a reduction of the frequency of seizures, while the remaining 11 were unmodified. There was 90% improvement in Primary Generalized seizures, 73% in Secondary Generalized and 62% in Partial Complex; 27% of PC, 16% of PG and 16% of SG shifted to polytherapy. Considering that monotherapy can be better managed and is less toxic, we can recommend it as first choice treatment in newcomers, as a maintenance therapy, and as treatment of choice for the gradual elimination of therapy.
authors.affiliation: Divisione Universitaria di Neurologia, Ospedale S. Luigi Gonzaga, Orbassano, Torino.
authors.forename: F
authors.initials: F
authors.lastname: Brignolio
authors.forename: L
authors.initials: L
authors.lastname: Verzè
authors.forename: M
authors.initials: M
authors.lastname: Baruchello
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002220:Carbamazepine / Q000627:therapeutic use*; D002648:Child; D004341:Drug Evaluation; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D010634:Phenobarbital / Q000627:therapeutic use*; D010672:Phenytoin / Q000627:therapeutic use*; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D010634:Phenobarbital
vernacular_title: Valutazione dell'efficacia della monoterapia nel trattamento dell'epilessia.