[Immunohistochemical studies of bronchial carcinoma using monoclonal antibody A63-C/A3].
An immunohistological study was undertaken, using paraffin sections of 22 cases of lung carcinoma and a number of reference tissue samples, to clear up the reactivity of A63-C/A63 monoclonal antibody (IgM) which was capable of identifying a carcinoma-associated carbohydrate antigen. Following neuraminidase pretreatment of those sections, positive response to the above antigen was produced by more than 90% of all bronchial carcinoma samples, notwithstanding the histological type involved (squamous-cell carcinoma or adenocarcinoma). Columnar epithelium of the bronchi, not involved in the neoplastic process gave a positive immunoreaction with the antibody A63-C/A3 in 64% of the cases.
Weber
S
S
Forschungsinstitut für Lungenkrankheiten und Tuberkulose, Berlin-Buch, BRD.
Reinhold-Richter
L
L
Karsten
U
U
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology; D000911:Antibodies, Monoclonal; D002276:Carcinoid Tumor / Q000737:chemistry / Q000473:pathology; D002283:Carcinoma, Bronchogenic / Q000737:chemistry / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology*; D008297:Male; D009439:Neuraminidase / Q000378:metabolism
D000911:Antibodies, Monoclonal; D009439:Neuraminidase
Immunhistochemische Untersuchung von Bronchialkarzinomen mit Hilfe des monoklonalen Antikörpers A63-C/A3.