Medication-nutrient interactions: hypophosphatemia associated with sucralfate in the intensive care unit.
Clinically significant medication-nutrient interactions are of concern to the nutritional support practitioner. To emphasize the possible effect of the aluminum-containing medication sucralfate on serum phosphorus levels, patients admitted to the intensive care unit of a small private hospital were monitored for a 4-week period. Sixteen patients demonstrated low serum phosphorus levels; eight (50%) of these were receiving sucralfate. Eighteen patients had no low phosphorus levels measured; five (28%) patients in this group were receiving sucralfate. The hypophosphatemia observed in these patients was probably multifactorial; respiratory alkalosis and dextrose feeding as well as sucralfate use are consistent with hypophosphatemia.
Miller
S J
SJ
Simpson
J
J
D000328:Adult; D000368:Aged; D003677:Deficiency Diseases / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology; D004750:Enteral Nutrition / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D010710:Phosphates / Q000097:blood*; D012307:Risk Factors; D013392:Sucralfate / Q000009:adverse effects*
D010710:Phosphates; D013392:Sucralfate