Amrinone for refractory cardiogenic shock following chloroquine poisoning.
Cardiac arrhythmias and circulatory collapse account for the high mortality reported after severe chloroquine poisoning. We have recently observed a 17-year-old man who ingested an 8 g chloroquine overdose. Cardiac arrest occurred within 1 h. Cardiogenic shock was refractory to epinephrine, dopamine and molar sodium lactate. Amrinone, a bipyridine analog, was then successfully used to improve haemodynamic conditions.
Hantson
P
P
Department of Intensive Care, Cliniques Universitaires St-Luc, Brussels, Belgium.
Ronveau
J L
JL
De Coninck
B
B
Horn
J L
JL
Mahieu
P
P
Hassoun
A
A
D000293:Adolescent; D000676:Amrinone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D016887:Cardiopulmonary Resuscitation / Q000592:standards; D002738:Chloroquine / Q000506:poisoning*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D011041:Poisoning / Q000150:complications*; D012770:Shock, Cardiogenic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013406:Suicide, Attempted
D002738:Chloroquine; D000676:Amrinone