Interspecies scaling of anesthetic potency.
Anesthetic potency data for 11 volatile anesthetics were correlated against body weight in multiple mammalian species, including man. The results indicate that the alveolar concentration necessary to produce anesthesia is approximately constant across species. Because alveolar ventilation rates scale with the 0.75 power of body weight, this implies that administered dose measured in mg/kg0.75/day produces the same anesthetic effect in all species. This analysis provides further support for the use of a mg/kg0.75/day interspecies scaling metric for acute toxic effects.
Travis
C C
CC
Risk Analysis Section, Oak Ridge National Laboratory, Tennessee 37831.
Bowers
J C
JC
D000777:Anesthetics / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D008322:Mammals; D011650:Pulmonary Alveoli / Q000378:metabolism*; D012044:Regression Analysis; D013045:Species Specificity
D000777:Anesthetics