Polymerase chain reaction polymorphisms in HLA-DQ alpha and IL6 from Mongoloid and Caucasoid populations.
Polymerase chain reaction polymorphisms have been used to study European, Chinese, Russian and Buryat populations at the HLA-DQ alpha and IL6 loci. DNA from individuals in these populations was specifically amplified at these loci, and analyzed either with allele-specific oligonucleotides for HLA-DQ alpha or directly on agarose gels for IL6. Allelic frequencies were calculated for each of the loci in each population. Comparisons between the population frequencies show that the Russian population is more closely related to Europeans, and that the Buryat population is more closely related to Chinese. This finding is in agreement with conclusions based on the phenotypic frequencies of classical blood-group and other protein markers in these populations.
Titenko
N V
NV
Laboratory of Ecogenetics, Academy of Medical Sciences of the USSR, Moscow.
Kurth
J H
JH
Bowcock
A M
AM
Cavalli-Sforza
L L
LL
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002681:China; D002897:Chromosomes, Human, Pair 7; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D005060:Europe; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008214:Lymphocytes / Q000276:immunology; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000276:immunology; D014586:USSR; D044465:White People / Q000235:genetics*
D004273:DNA, Neoplasm; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D015850:Interleukin-6; D015345:Oligonucleotide Probes