Difference in the developmental toxicity of ethylenethiourea and three N,N'-substituted thiourea derivatives in rats.
Sprague-Dawley rats were administered ethylenethiourea (ETU), 1,3-dimethyl-2-thiourea (DMT), 1,3-dibutyl-2-thiourea (DBT), or 1,3-diphenyl-2-thiourea (DPT) by gavage from Days 6 to 20 of gestation. Daily dosage levels (mg/kg/day) were ETU at 0, 15, 25 and 35; DMT at 0, 15, 25, 50, 100, and 200; DBT at 0, 15, 25, 50, 100, and 200; and DPT at 0, 25, 50, 100, and 200. There was evidence of maternal toxicity at all doses of DMT and at doses greater than or equal to 50 mg DBT/kg/day. DPT was embryolethal at 200 mg/kg/day. Fetotoxicity was observed at doses greater than or equal to 15 mg DMT/kg/day, greater than or equal to 15 mg DBT/kg/day, and greater than or equal to 100 mg DPT/kg/day. ETU was the only chemical tested that proved to be teratogenic.
Saillenfait
A M
AM
Institut National de Recherche et de Sécurité, Vandoeuvre, France.
Sabate
J P
JP
Langonne
I
I
de Ceaurriz
J
J
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects; D005031:Ethylenethiourea / Q000633:toxicity*; D005260:Female; D005865:Gestational Age; D007441:Intubation, Gastrointestinal; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens / Q000633:toxicity*; D013890:Thiourea / Q000031:analogs & derivatives / Q000633:toxicity*
D013723:Teratogens; D005031:Ethylenethiourea; C034546:1,3-dibutyl-2-thiourea; C038983:1,3-dimethylthiourea; C032788:diphenylthiourea; D013890:Thiourea