[The effect of cyclooxygenase inhibition on the indices of the thrombocyte-vascular link in hemostasis and on the free-radical processes of lipid oxidation in experimental Salmonella intoxication].
Injection of Salmonella typhimurium endotoxin to the laboratory animals (rabbits) in dose of 1 mg/ml (LD84) induces the particular changes in the thrombocyte vessels system of hemostasis: decrease of aggregatory ability of thrombocytes, increase of thromboxane A2 and prostacyclin activation of lipid peroxidation process. Use of indomethacin--the cyclooxygenase inhibitor--leads to less progressive alterations of the studied parameters of the thrombocyte vessels hemostasis and lipid peroxidation processes.
Malov
V A
VA
Studennikova
L N
LN
Pak
S G
SG
SAchek
M M
MM
Vinnitskiĭ
L I
LI
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004731:Endotoxins; D005609:Free Radicals; D006487:Hemostasis / Q000187:drug effects*; D007213:Indomethacin / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D012481:Salmonella Infections, Animal / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D012486:Salmonella typhimurium
D016861:Cyclooxygenase Inhibitors; D004731:Endotoxins; D005609:Free Radicals; D007213:Indomethacin
Vliianie ingibirovaniia tsiklooksigenazy na pokazateli trombotsitarno-sosudistogo zvena gemostaza i protsessy svobodnoradikal'nogo okisleniia lipidov pri éksperimental'noĭ sal'monelleznoĭ intoksikatsii.