[Immune shifts and their correction in the extremely severe course of diffuse suppurative peritonitis in children].
Clinical and immunological studies of 65 patients with extremely severe disseminated suppurative peritonitis have revealed profound disturbances in their immune status. A considerable (2.5-3-fold) decrease in phagocytosis and complement activity, a drastic drop in T-, B-lymphocyte and T-helper content and a depression in T-lymphocyte functional activity have been observed. All this was accompanied by the activation of allergic and autoimmune reactions. Single transfusion of extracorporally X-ray-irradiated autoblood (5-7% of circulating blood volume) promoted an earlier normalization of the patients' critical condition and a prompt correction of the immune shifts.
Kushch
N L
NL
Iulish
E I
EI
Prikhodchenko
V V
VV
Agaev
A A
AA
Kushch
N N
NN
D000293:Adolescent; D001064:Appendicitis / Q000150:complications; D001769:Blood / Q000528:radiation effects*; D001804:Blood Transfusion, Autologous; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007111:Immunity, Cellular; D010538:Peritonitis / Q000209:etiology / Q000276:immunology* / Q000628:therapy
Immunnye sdvigi i ikh korrektsiia pri kraĭne tiazhelom techenii razlichnogo gnoĭnogo peritonita u deteĭ.