title: Acute fatal Trypanosoma cruzi meningoencephalitis in a human immunodeficiency virus-positive hemophiliac patient.
abstract: A 37-year-old hemophiliac patient with known, asymptomatic human immunodeficiency virus infection and chronic Chagas' disease was admitted to the hospital complaining of fever and headache. A computed tomographic scan revealed multiple ring-enhancing lesions in both cerebral hemispheres. No antibodies to Trypanosoma cruzi were found in the cerebrospinal fluid. Treatment for toxoplasmosis of the central nervous system, which was considered the most likely diagnosis, was instituted, but the patient died after progressive neurologic deterioration. An autopsy revealed severe meningoencephalitis caused by T. cruzi.
authors.affiliation: Centro de Ciencias Biomedicas, Universidade Federal de Uberlandia, Brazil.
authors.forename: M S
authors.initials: MS
authors.lastname: Ferreira
authors.forename: S de A
authors.initials: Sde A
authors.lastname: Nishioka
authors.forename: A
authors.initials: A
authors.lastname: Rocha
authors.forename: A M
authors.initials: AM
authors.lastname: Silva
authors.forename: R G
authors.initials: RG
authors.lastname: Ferreira
authors.forename: W
authors.initials: W
authors.lastname: Olivier
authors.forename: S
authors.initials: S
authors.lastname: Tostes Júnior
mesh_terms: D000208:Acute Disease; D000328:Adult; D000818:Animals; D014355:Chagas Disease / Q000150:complications*; D015658:HIV Infections / Q000150:complications*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000469:parasitology*; D014349:Trypanosoma cruzi