title: [Prevalence of reactions to drugs in 251 patients with urticaria-angioedema syndrome].
abstract: We studied 251 outpatients affected by chronic and acute urticaria-angioedema syndrome, triggered or exacerbated by drugs, to evaluate the prevalence of adverse reactions to each pharmacological group. Among these patients, 134 (53.4%) presented one or more adverse reactions to a single drug: 100 (74.7%) reacted to NSAIDs, 33 (24.7%) to antibiotics and 1 to B vitamin complex. The remaining 117 patients (46.6%) presented adverse reactions to more than one drug. Considering the patients all together, 123 (49%) had adverse reactions to ASA, 116 (46.2%) to pyrazones, 65 (25.9%) to antibiotics, 26 (10.3%) to NSAIDs different from ASA and pyrazones. In our experience, according to other reports, there is a greater frequency of drug reactions to NSAIDs vs other drugs. ASA is the more frequently involved drug.
authors.affiliation: Spedali Civili di Brescia, Cattedra di Immunologia Clinica, Università degli Studi di Brescia.
authors.forename: M
authors.initials: M
authors.lastname: Braga
authors.forename: R
authors.initials: R
authors.lastname: Cattaneo
authors.forename: F
authors.initials: F
authors.lastname: Soldati
authors.forename: M T
authors.initials: MT
authors.lastname: Franzini
authors.forename: C
authors.initials: C
authors.lastname: Tosoni
mesh_terms: D000799:Angioedema / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D013577:Syndrome
vernacular_title: Prevalenza di reazioni a farmaci in 251 pazienti affetti da sindrome orticaria-angioedema.