[Trial of amitriptyline versus flunarizine as treatment of vestibular diseases. A preliminary study].
109 patients with vestibular disease were included in two different treatments with amitriptyline (Group A:53 patients with depressive symptoms), or flunarizine (Group B: 56 patients). Vertiginous symptoms, basic vestibular exploration, depressive disorder, cochlear symptoms, vegetative disorders and headache were evaluated. Among the patients treated with amitriptyline a significant decrease in the vertiginous symptoms were observed. The possible mechanism of action were analyzed too.
Pardal Refoyo
J L
JL
Servicio de ORL, Hospital Clínico Universitario, Salamanca.
Beltrán Mateos
L D
LD
D000639:Amitriptyline / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy; D005260:Female; D005444:Flunarizine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014717:Vertigo / Q000188:drug therapy; D015837:Vestibular Diseases / Q000188:drug therapy*
D000639:Amitriptyline; D005444:Flunarizine
Ensayo de amitriptilina versus flunarizina como tratamiento en patología vestibular. Estudio preliminar.