Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer's and Parkinson's diseases.
The binding of the selective 5-HT2 antagonist [3H]ketanserin has been investigated in the temporal cortex of patients with Alzheimer's disease (SDAT), Parkinson's disease (PD), senile dementia of Lewy body type (SDLT) and neuropathologically normal subjects (control). 5-HT2 binding was reduced in SDAT, PD with dementia and SDLT. SDAT showed a 5-HT2 receptor deficit across most of the cortical layers. A significant decrease in 5-HT2 binding in the deep cortical layers was found in those SDLT cases without hallucinations. SDLT cases with hallucinations only showed a deficit in one upper layer. There was a significant difference in cortical layers III and V between SDLT without hallucinations and SDLT with hallucinations. The results confirm an abnormality of serotonin binding in various forms of dementia and suggest that preservation of 5-HT2 receptor in the temporal cortex may differentiate hallucinating from non-hallucinating cases of SDLT.
Cheng
A V
AV
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, U.K.
Ferrier
I N
IN
Morris
C M
CM
Jabeen
S
S
Sahgal
A
A
McKeith
I G
IG
Edwardson
J A
JA
Perry
R H
RH
Perry
E K
EK
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D003704:Dementia / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006212:Hallucinations / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007650:Ketanserin / Q000378:metabolism; D016631:Lewy Bodies; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000145:classification / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism*
D011985:Receptors, Serotonin; D012701:Serotonin; D007650:Ketanserin