The structure-activity relationship of inhibitors of serotonin uptake and receptor binding.
An analysis of five different datasets of inhibitors of serotonin uptake has yielded quantitative structure/activity relationships (QSARs) which delineate the role of steric and hydrophobic properties essential for inhibition by phenylethylamine-type analogues.
Hansch
C
C
Department of Chemistry, Pomona College, Claremont, CA 91711.
Caldwell
J
J
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D003198:Computer Simulation; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D010627:Phenethylamines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship
D010627:Phenethylamines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin