[Effect of intra-arterial and intravenous PGE1 infusions on transcutaneous oxygen pressure in patients with critical ischemia of the extremities].
In a randomized cross-over study 20 patients with peripheral arterial occlusive disease stage IV according to Fontaine received one i.a. infusion of 10 micrograms PGE1 in 25 ml saline over 30 min and one i.v. infusion of 40 micrograms PGE1 in 125 ml saline over 60 min. Transcutaneous PO2 was measured continuously (44 degrees C) on the forefoot and dorsum of the foot of the affected leg as well as on the forefoot of the contralateral limb. During i.a. infusion tcPO2 decreased by 73% on the forefoot combined with pain in the infused leg in 8 patients, whereas i.v. infusion induced a 83.1% increase in tcPO2. All in all i.v. PGE1 infusion resulted in a more pronounced increase of tcPO2 without causing side effects.
Weiss
T
T
Medizinische Universitätsklinik Heidelberg.
Griesshaber
J
J
Rogatti
W
W
Kistner
O
O
Hsu
E
E
Jansen
T
T
Diehm
C
C
D000527:Alprostadil / Q000008:administration & dosage*; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000188:drug therapy*; D001785:Blood Gas Monitoring, Transcutaneous; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D007511:Ischemia / Q000097:blood / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*
D000527:Alprostadil
Einfluss von i.a. und i.v. PGE1 Infusionen auf den transkutanen Sauerstoffdruck bei Patienten mit kritischer Extremitätenischämie.