title: Effect of diazinon on freeze-fracture images of microvilli of intestinal epithelial cells of Tilapia nilotica.
abstract: The effect of the organophosphate insecticide, diazinon on the intramembranous particles (IMPs) of the microvilli of the intestinal epithelial cells of Tilapia nilotica fish was studied using freeze-fracture technique. Exposing fish to different repeated concentrations of diazinon (1/2LC50) caused a significant decrease in population density of IMPs in P- and E-faces. IMPs of microvilli found in intestinal epithelial cells are thought to represent many kinds of proteins including enzymes. In the present work, it is suggested that diazinon induced a reduction in enzymatic content of the membrane which was accompanied by a decrease in IMPs density of the microvilli.
authors.affiliation: Zoology Dept., Faculty of Science, Menoufia University Egypt.
authors.forename: S A
authors.initials: SA
authors.lastname: Sakr
authors.forename: S A
authors.initials: SA
authors.lastname: Gabr
authors.forename: M M
authors.initials: MM
authors.lastname: el-Saadany
mesh_terms: D000818:Animals; D003976:Diazinon / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D005399:Fishes / Q000033:anatomy & histology*; D005614:Freeze Fracturing; D005618:Fresh Water; D007422:Intestines / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008871:Microvilli / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D003976:Diazinon