title: Concentrations of blood and urine ethanol, acetaldehyde, acetate and acetone during experimental hangover in volunteers.
abstract: Blood and urine samples were analyzed for ethanol, acetaldehyde, acetate and acetone during experimental hangover in 6 healthy male volunteers (A, B, C, D, E, F). They drank freely for some 4 hr. In flushers (A, F) at 9 hr after ingestion (ethanol: 92 g, 1.2 g/kg and 1.3 g/kg), acetaldehyde levels were low in the blood, but high in the urine (37 microM, 45 microM). Heavy drinkers, non-flushers of B (ethanol: 176 g, 2.5 g/kg), C (157 g, 2.4 g/kg) and E (182 g, 2.9 g/kg) had a slightly high [lactate]/[pyruvate] ratio and 3-hydroxybutyrate in the blood at 11 hr after alcohol ingestion. Blood ethanol levels were dose dependent and blood acetaldehyde in B and C had a slightly high 6.3 microM and 8.0 microM 9 hr later, respectively. B, C and E had a high urine acetone concentration (100 microM over) in hangover. In C, in particular, urine acetate and acetone levels were unusually high. The ratio in blood (urine) among alcohol metabolites at 9 hr after drinking was approximately ethanol 1000 (1000): acetaldehyde 0.2-1.0 (0.1-5.9): acetate 36-163 (22-1554): acetone 1-11 (3-47).
authors.affiliation: Department of Legal Medicine, Nihon University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Tsukamoto
authors.forename: T
authors.initials: T
authors.lastname: Kanegae
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Nagoya
authors.forename: M
authors.initials: M
authors.lastname: Shimamura
authors.forename: H
authors.initials: H
authors.lastname: Tainaka
authors.forename: M
authors.initials: M
authors.lastname: Kawaguchi
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism*; D000085:Acetates / Q000378:metabolism*; D000096:Acetone / Q000378:metabolism*; D000328:Adult; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism*; D006801:Humans; D008297:Male
chemical_list: D000085:Acetates; D000096:Acetone; D000431:Ethanol; D000079:Acetaldehyde