Effects of ambient glycaemic state on growth hormone responsiveness in insulin-dependent diabetes.
OBJECTIVE
We wished to examine the effects of ambient glycaemia on hypothalamic somatostatinergic tone in insulin-dependent diabetes mellitus.


METHODS
After 6-hour periods of either euglycaemia (5 mmol/l) or hyperglycaemia (15 mmol/l), exercise-induced GH secretion was measured.


METHODS
Seven insulin dependent diabetics with no evidence of complications were recruited.


RESULTS
There was no significant difference between basal GH levels during euglycaemia and hyperglycaemia (5.50 vs 5.53 mU/l). Nor was there a significant difference when mean delta GH levels (33.9 vs 27.4 mU/l) or mean area under GH curve (2331 vs 4038 mU min/l) during euglycaemia or hyperglycaemia were compared.


CONCLUSIONS
We find no evidence therefore to support short-term effects of ambient glucose concentration on GH responsiveness, and by inference no direct effect of short-term changes in glycaemic control on hypothalamic release of somatostatin in the aetiology of GH hypersecretion in insulin-dependent diabetes mellitus.
Ismail
I S
IS
Department of Medicine, University of Wales College of Medicine, Cardiff, UK.
Scanlon
M F
MF
Peters
J R
JR
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000503:physiopathology; D005080:Exercise Test; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism* / Q000503:physiopathology
D001786:Blood Glucose; D013006:Growth Hormone