[Impaired fibrinolytic response to the venous occlusion test in patients with cryptogenic colitis].
The fibrinolytic response to venous occlusion was studied in 17 patients with inflammatory bowel disease: 7 with Crohn's disease, 10 with ulcerative colitis and compared with those obtained in 20 controls. Patients with inflammatory bowel disease showed decreased tissue-type plasminogen activator antigen release (t-PA Ag), no significant Von Willebrand antigen release (vWF Ag), and a residual plasminogen activator inhibitor activity (PAI activity) after venous occlusion. These modifications were more important in the evolutive colitis group compared with the remission group. Hypofibrinolysis, as defined by a defective t-PA release, and a residual PAI activity after venous occlusion might contribute to digestive and/or extra digestive thrombotic manifestations observed during the course of inflammatory bowel diseases.
Gris
J C
JC
Laboratoire d'Hématologie et Immunologie, CHRU, Nîmes.
Schved
J F
JF
Raffanel
C
C
Dubois
A
A
Ribard
D
D
Balmes
J L
JL
D000328:Adult; D003093:Colitis, Ulcerative / Q000503:physiopathology*; D003424:Crohn Disease / Q000503:physiopathology*; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D010960:Plasminogen Activators / Q000032:analysis; D015849:Plasminogen Inactivators / Q000032:analysis; D012016:Reference Values; D014841:von Willebrand Factor / Q000032:analysis
D015849:Plasminogen Inactivators; D014841:von Willebrand Factor; D010960:Plasminogen Activators
Réponse anormale au test d'occlusion veineuse chez les patients atteints de colite cryptogénique.