title: The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon.
abstract: The styrylpyrone, goniodiol-7-monoacetate [1] [6R-(7R,8R-dihydro-7-acetoxy-8-hydroxystyryl)-5, 6-dihydro-2-pyrone], has been isolated from Goniothalamus amuyon, and its detailed molecular structure has been determined by X-ray crystallographic analysis. Goniodiol-7-monoacetate showed potent (ED50 values less than 0.1 microgram/ml) cytotoxicities against KB, P-388, RPMI, and TE671 tumor cells.
authors.affiliation: School of Pharmacy, Department of Microbiology, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: Y C
authors.initials: YC
authors.lastname: Wu
authors.forename: C Y
authors.initials: CY
authors.lastname: Duh
authors.forename: F R
authors.initials: FR
authors.lastname: Chang
authors.forename: G Y
authors.initials: GY
authors.lastname: Chang
authors.forename: S K
authors.initials: SK
authors.lastname: Wang
authors.forename: J J
authors.initials: JJ
authors.lastname: Chang
authors.forename: D R
authors.initials: DR
authors.lastname: McPhail
authors.forename: A T
authors.initials: AT
authors.lastname: McPhail
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D003460:Crystallization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D015394:Molecular Structure; D010946:Plants, Medicinal; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013343:Styrenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011753:Pyrones; D013343:Styrenes; C073082:goniodiol-7-monoacetate