[The preliminary study on aluminum toxicity to mice].
Mice were tested orally to study the toxic effects of Al on their skeleton and brain. The results showed that the Al content in brain increased along with its intake increase, but pathological examination of brain revealed no apparent change between test and control groups. Relative femur weight of mice in the highest dose group was lower than those of the other groups (P less than 0.05). The bone Al content was increased along with Al intake increase (P less than 0.05). There was negative correlation between the bone Al content and relative femur weight (P less than 0.05), and positive correlation between the bone Al content and the Al intake (P less than 0.01). Pathological examination of femurs revealed that the pathological changes of osteoporosis and osteoblast atrophy tended to increase while both Al intake and bone Al content were increased.
Huang
G W
GW
Department of Nutrition and Food Hygiene, Tianjin Medical College.
Xu
G S
GS
D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism / Q000473:pathology; D005260:Female; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects
D000535:Aluminum