Spontaneously occurring leiomyosarcomas of the mouse urinary bladder.
Spontaneous leiomyosarcomas of the mouse urinary bladder have not been reported. Data from 8 chronic toxicity/oncogenicity studies that included 400 male and 400 female mice were reviewed and evaluated to gather information on spontaneously occurring urinary bladder leiomyosarcomas. Three control mice from 3 different studies had leiomyosarcomas in the submucosa of the trigone area of the urinary bladder. These tumors were not connected to the surface epithelium; however, they were connected to and destroyed the smooth muscle layer of the urinary bladder. This communication describes the incidence and histopathological features of these neoplasms.
Chandra
M
M
Experimental Pathology Department, American Cyanamid Company, Pearl River, New York 10965.
Frith
C H
CH
D000818:Animals; D005260:Female; D015994:Incidence; D007890:Leiomyosarcoma / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology* / Q000473:pathology