Genetic and immunological studies on polypeptides encoded by the vir locus of Bordetella pertussis.
We report here the results of genetic and immunological studies of the vir locus of Bordetella pertussis. These studies have allowed the determination of the cellular compartment that each of the vir-encoded polypeptides occupies, and have allowed the detection of each of them in crude extracts of Bordetella pertussis cells. From these studies it can be seen that the vir locus encodes two polypeptides, one a transmembrane sensing and signalling protein and the second a cytoplasmic regulatory protein. These proteins belong to the family of bacterial regulatory proteins known as two-component systems. A simple model for signal transduction in this organism is put forward.
Stibitz
S
S
Center for Biological Evaluation and Research, Food and Drug Administration, Bethesda, MD.
Yang
M S
MS
D001426:Bacterial Proteins / Q000235:genetics* / Q000276:immunology; D001886:Bordetella pertussis / Q000235:genetics* / Q000276:immunology; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D008954:Models, Biological; D009154:Mutation; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology; D037521:Virulence Factors
D001426:Bacterial Proteins; C065601:BvgA protein, Bacteria; D011993:Recombinant Fusion Proteins; D014157:Transcription Factors; D037521:Virulence Factors