title: Polymyositis complicating D-penicillamine treatment.
abstract: Although there is good evidence that D-penicillamine can induce polymyositis, the exact pathogenic mechanism remains unclear. We report two patients with psoriatic arthritis and primary biliary cirrhosis respectively, who developed polymyositis while receiving D-penicillamine treatment for their primary diseases. Whether D-penicillamine treatment was the sole cause of polymyositis or acted as a trigger for the development of a secondary autoimmune disease is discussed.
authors.affiliation: Lupus Arthritis Research Unit, Rayne Institute, St Thomas' Hospital, London, UK.
authors.forename: A O
authors.initials: AO
authors.lastname: Aydintug
authors.forename: R
authors.initials: R
authors.lastname: Cervera
authors.forename: D
authors.initials: D
authors.lastname: D'Cruz
authors.forename: G
authors.initials: G
authors.lastname: Ramírez
authors.forename: R A
authors.initials: RA
authors.lastname: Asherson
authors.forename: M A
authors.initials: MA
authors.lastname: Khamashta
authors.forename: G R
authors.initials: GR
authors.lastname: Hughes
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000188:drug therapy*; D008875:Middle Aged; D009220:Myositis / Q000139:chemically induced*; D010396:Penicillamine / Q000009:adverse effects*
chemical_list: D010396:Penicillamine