title: Synthesis and pharmacological screening of some new N-[4-(N,N-disubstituted aminocarbonyl)phenyl]-3,5-dinitrobenzoic acid hydrazides.
abstract: Ten title compounds were synthesized by the action of N-[4-carboxyphenyl]-3,5-dinitrobenzoic acid hydrazide with thionyl chloride, followed by condensation with different secondary amines. The synthesized compounds were screened for toxicity, gross central nervous system, cardiovascular and anti-inflammatory activities. Most of the compounds were found to be moderately toxic and to depress the central nervous system. Some of them showed anti-inflammatory activity against carrageenin-induced oedema. Certain compounds displayed mild cardiovascular activity.
authors.affiliation: Chemistry Department, Lucknow University, India.
authors.forename: S
authors.initials: S
authors.lastname: Swarup
authors.forename: V K
authors.initials: VK
authors.lastname: Saxena
authors.forename: C R
authors.initials: CR
authors.lastname: Prasad
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000633:toxicity; D002351:Carrageenan; D002415:Cats; D004136:Dinitrobenzenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D051381:Rats; D013055:Spectrophotometry, Infrared
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002317:Cardiovascular Agents; D004136:Dinitrobenzenes; D006834:Hydrazines; D002351:Carrageenan