[Reparation of the vascular wall after laser recanalization of the artery (characteristics of changes in the vascular wall at a late period after laser recanalization)].
Chronic experimental studies were carried out on 9 mongrel dogs. To study the reparation processes in the arterial wall after laser intervention, arteries of different anatomic zones were irradiated with laser: descending and abdominal aorta, iliac, femoral and axillary arteries. To make a laser trauma, two types of laser catheters were used: a) with the light guide with diameter of 400 and 600 microns; and b) with a quartz tip at the end. The laser light source was a laser of Cu vapors, and ND; YAG laser. Laser energy was transmitted in the form of individual impulses with the duration of 2-5 sec, and power of 8-10 watt. Histological studies of the preparations of the irradiated arterial wall were performed at periods: 1-3-7-16-28 days, and 2-8 months. Characteristic signs of the vascular wall reparations are given. The analysis of the experimental results showed that by the 28-th day after laser trauma, on the site of laser irradiation a connective tissue scar was formed substituting the defect in the vascular wall and covered from the lumen side with a thin continuous layer of endothelium without any signs of inflammatory infiltration. The development of intimal hyperplasia is not excluded, as well as of inflammatory reaction with the following thrombotic occlusion of the artery lumen. The study results can be used in clinical practice in order to determine the optimum tactics and performance of laser recanalization of the artery, as well as the treatment after the laser intervention.
Natsvlishvili
Z G
ZG
Sheremet'eva
G F
GF
Babunashvili
A M
AM
D016342:Angioplasty, Laser / Q000295:instrumentation; D000818:Animals; D001158:Arteries / Q000473:pathology*; D004285:Dogs; D005500:Follow-Up Studies; D006965:Hyperplasia; D007249:Inflammation; D013997:Time Factors
Reparatsiia sosudistoĭ stenki lazernoĭ rekanalizatsii arterii (kharakteristika izmeneniĭ v stenke sosuda v otdalennye sroki posle lazernoĭ rekanalizatsii).