[Use of tuftsin in experimental leprosy].
The effect of tuftsin was studied in vivo using CBA mice infected with M. leprae by Shepard's technique and in vitro using macrophage-like cell line P. 388 (Co-cultivated with M. leprae) and the cultivated leproma tissue. It was found out that tuftsin acted as a stimulator of M. leprae multiplication in foot-pads of mice and as a prolongator of M. leprae survival in the cells of macrophage-like cell line P .388. It is concluded that using tuftsin might be useful in view of studying different aspects of experimental leprosy.
Vishnevetskiĭ
F E
FE
Freĭdlin
I S
IS
Iushchenko
A A
AA
Vishnevetskiĭ
R F
RF
Anokhina
V V
VV
Urliapova
N G
NG
Iushin
M Iu
MIu
Eskina
I M
IM
D000818:Animals; D002460:Cell Line; D003622:Dapsone / Q000627:therapeutic use; D007918:Leprosy / Q000188:drug therapy*; D051379:Mice; D008808:Mice, Inbred CBA; D009166:Mycobacterium leprae / Q000254:growth & development; D012293:Rifampin / Q000627:therapeutic use; D014405:Tuftsin / Q000627:therapeutic use*
D003622:Dapsone; D014405:Tuftsin; D012293:Rifampin
Primenenie taftsina v éksperimental'noĭ leprologii.