title: Biology and pathophysiology of Toxocara vitulorum infections in a rabbit model.
abstract: Ten female New Zealand rabbits were infected via stomach intubation with eggs of Toxocara vitulorum at a dosage of 10 embryonated eggs per gram of body weight on Days 0, 35 and 72. Ten or 4% of the administered parasites passed in the feces during the 3 days following the first or second infection, but 32% after the third infection. Many larvae were passed in the third infection, but not in the first or second. Tissue parasite yields were 4.1% on Day 5, 2% on Day 15, 0.8% on Day 30, 0.1% on Day 65 and 0.06% on Day 101. Five hundred and ninety-three larvae were recovered from liver, 243 from lungs and 0 from muscles on Day 5; 282 from liver, 138 from lungs and 21 from muscles on Day 15; 151 from liver, 21 from lungs and 50 from muscles on Day 30; 0 from liver, 26 from lungs and 15 from muscles on Day 65; 0 from liver, 0 from lungs and 9 from muscles on Day 101. No larvae were found in other tissues. The size of the muscle larvae at 30, 65 and 101 days indicated that the parasites did not develop beyond the infective stage and suggested that they were probably hypobiotic organisms. Erythrocytes, packed cell volume and monocytes decreased, but eosinophils and basophils increased, after each infection. Serum enzyme levels indicated that liver damage occurred only after the first infection, but muscle injury occurred after each infection and was increasingly more precocious after each infection.
authors.affiliation: Department of Veterinary Preventive Medicine, Ohio State University, Columbus 43210.
authors.forename: H M
authors.initials: HM
authors.lastname: Omar
authors.forename: O O
authors.initials: OO
authors.lastname: Barriga
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005243:Feces / Q000469:parasitology; D005260:Female; D007441:Intubation, Gastrointestinal / Q000662:veterinary; D007814:Larva; D010270:Parasite Egg Count / Q000662:veterinary; D011817:Rabbits; D013997:Time Factors; D014120:Toxocariasis / Q000469:parasitology* / Q000503:physiopathology