[A parallel study between the magnitude of smooth-muscle contraction in vitro and the prostanoid content of the incubation medium of the preparation after the introduction of blood serum from women].
An attempt is made to establish dependence between stimulation of smooth-muscle contraction and the concentration of prostanoids in biologically active sera of women on the basis of two various methods: physiological test with smooth-muscle strips in vitro and radioimmunological determination of prostanoids. Three prostanoids are examined PgF2 alpha PgI2, TxA2 are examined and it is found that lineal dependence between the prostanoid concentration and activation of contraction (for the whole range) is observed only for PgF2 alpha, which allows graphic interpolation for this prostaglandin.
Milieva
E
E
Milkov
V
V
Krumov
G
G
Srents
A
A
D000022:Abortion, Spontaneous / Q000097:blood; D000818:Animals; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D010477:Perfusion / Q000379:methods; D011247:Pregnancy; D011453:Prostaglandins / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*
D011453:Prostaglandins
Paralelno izsledvane mezhdu goleminata na gladkomuskulnoto sŭkrashtenie in vitro i sŭdŭrzhanieto na prostanoidi v inkubatsionnata sreda na preparata sled vŭvezhdena na krŭven serum ot zheni.