title: Immunohistochemical expression of epidermal growth factor receptors in nuclei of a subpopulation of keratinocytes and sweat gland cells.
abstract: We have raised a polyclonal antibody to the 170-kD epidermal growth factor receptor. We found an intercellular pattern of immunoreactivity in the epidermis as well as a positivity of the cytoplasm of keratinocytes and eccrine secretory cells. In some samples, a nuclear labelling was evidenced in these type of cells. There is a close resemblance in the topographical distribution of these cells with nuclear labelling and those synthesizing DNA under phytohaemagglutinin stimulation.
authors.affiliation: Department of Dermatopathology, University of Liège, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Piérard-Franchimont
authors.forename: A
authors.initials: A
authors.lastname: Colige
authors.forename: J
authors.initials: J
authors.lastname: Arrese Estrada
authors.forename: C M
authors.initials: CM
authors.lastname: Lapière
authors.forename: G E
authors.initials: GE
authors.lastname: Piérard
mesh_terms: D002462:Cell Membrane / Q000737:chemistry; D002467:Cell Nucleus / Q000737:chemistry; D066246:ErbB Receptors / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000737:chemistry* / Q000648:ultrastructure; D013545:Sweat Glands / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D066246:ErbB Receptors