title: Monitoring of exposure to cyclohexanone through the analysis of breath and urine.
abstract: Occupational exposure to cyclohexanone was studied for 59 workers through the analysis of environmental air, alveolar air, and urinary cyclohexanol. Environmental cyclohexanone exposure was measured by personal sampling with a carbon-felt passive dosimeter. Cyclohexanone in alveolar air and cyclohexanol in urine were determined with gas chromatography with a flame ionization detector. The end-of-shift urinary cyclohexanol levels correlated well with the time-weighted average environmental cyclohexanone values (r = 0.66). Urinary cyclohexanol corrected for creatinine correlated best with cyclohexanone in air (r = 0.77); when corrected for specific gravity, it gave a similar correlation coefficient (r = 0.73). When the time-weighted average of the exposure was 25 ppm, the corresponding calculated concentration for urinary cyclohexanol was 54.5 mg/1, 23.3 mg/g of creatinine, or 43.5 mg/l at a specific gravity of 1.018. The relationship between cyclohexanone exposure and its concentration in exhaled breath was found to be poorer than that for cyclohexanone exposure and the urinary metabolite (r = 0.51).
authors.affiliation: Department of Community Occupational and Family Medicine, National University of Singapore.
authors.forename: C N
authors.initials: CN
authors.lastname: Ong
authors.forename: S E
authors.initials: SE
authors.lastname: Chia
authors.forename: W H
authors.initials: WH
authors.lastname: Phoon
authors.forename: K T
authors.initials: KT
authors.lastname: Tan
authors.forename: P W
authors.initials: PW
authors.lastname: Kok
mesh_terms: D000293:Adolescent; D000328:Adult; D001944:Breath Tests; D003512:Cyclohexanones / Q000493:pharmacokinetics*; D004784:Environmental Monitoring; D006801:Humans; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D016273:Occupational Exposure; D016272:Occupational Health
chemical_list: D003512:Cyclohexanones; C036468:cyclohexanone