Effects of intramedullary reaming and nailing of rat femur. A mechanical and chemical study.
This study was undertaken to explore the association between mechanical and chemical effects of intramedullary reaming and nailing. The right femora of 80 rats were reamed and nailed with steel nails. Forty rats were evaluated from 3 days to 24 weeks postoperatively. The other 40 rats had the nail removed after 12 weeks, and they were then followed from 3 days to 24 weeks after nail extraction. Evaluation consisted of in vivo strain recording, geometric measurements, mechanical three-point bending test, and chemical analyses of hydroxyproline and calcium contents. Reaming and nailing caused immediate weakening of the bone as measured by in vitro mechanical tests, but within 3 weeks the mechanical properties were fully restored, whereas in vivo strain remained reduced throughout the experimental period in rats with nails. Removing the nail increased in vivo strain to a level close to that of the intact femur. Remodeling of the bone resulted in greater external anteroposterior diameter, cross-sectional area, area moment of inertia, and amount of hydroxyproline and calcium in the operated on femur as compared with the intact side. This indicates that the repair processes resulted in greater bone mass of the operated on femur than of the intact femur. Thus, there is evidence that nailing techniques effectively assist tissues by repair and remodeling.
Indrekvam
K
K
University of Bergen, Surgical Research Laboratory, Norway.
Gjerdet
N R
NR
Engesaeter
L B
LB
Langeland
N
N
D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density; D002118:Calcium / Q000032:analysis; D003094:Collagen / Q000737:chemistry; D005269:Femur / Q000737:chemistry / Q000502:physiology / Q000601:surgery*; D005594:Fracture Fixation, Intramedullary; D006909:Hydroxyproline / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013718:Tensile Strength
D003094:Collagen; D006909:Hydroxyproline; D002118:Calcium