B-lymphocyte mitogenicity and adjuvanticity of an ornithine-containing lipid or a serine-containing lipid.
An ornithine-containing lipid (Orn-L) or a serine-containing lipid (Ser-L) from Flavobacterium meningosepticum exhibited strong mitogenicity for the splenocytes from both LPS-responder C3H/HeSlc and LPS-low-responder C3H/HeJ mice. The potency of the lipoamino acids was the same as that of LPS for responder mice. The lipoamino acids were B-lymphocyte mitogens. Furthermore, Orn-L or Ser-L exhibited strong adjuvanticity. Compared with the adjuvanticity of LPS, the activity of Orn-L was rather high. Based on these data, together with the previously reported data of macrophage activation, we propose that the lipoamino acids are non-toxic, potent immunoactivators.
Kawai
Y
Y
Department of Bacteriology, National Institute of Health, Tokyo, Japan.
Kamoshita
K
K
Akagawa
K
K
D000276:Adjuvants, Immunologic; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D005417:Flavobacterium / Q000276:immunology*; D008055:Lipids / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D009952:Ornithine / Q000031:analogs & derivatives* / Q000276:immunology; D012694:Serine / Q000031:analogs & derivatives* / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000276:Adjuvants, Immunologic; D008055:Lipids; D008070:Lipopolysaccharides; C051524:ornithine containing aminolipid; C069989:serine containing aminolipid; D012694:Serine; D009952:Ornithine