Recognition of complex oligosaccharides by the multi-subunit asialoglycoprotein receptor.
The hepatic asialoglycoprotein receptor, a galactose lectin, is an oligomer of two types of similar polypeptide chains, each of which weakly binds galactose. High-affinity binding of complex oligosaccharides requires a precise geometric arrangement of receptor subunits. The two subunits have different functions in receptor assembly, ligand binding and endocytosis.
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Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.
D000818:Animals; D037263:Asialoglycoprotein Receptor; D002240:Carbohydrate Sequence; D006801:Humans; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
D037263:Asialoglycoprotein Receptor; D009844:Oligosaccharides; D011971:Receptors, Immunologic