Relationships of haptoglobin level to FEV1, wheezing, bronchial hyper-responsiveness and allergy.
The relationships of haptoglobin level to respiratory and allergic parameters have been assessed in an epidemiological study conducted in a working population surveyed twice 5 years apart. At the first survey conducted in 892 working men, haptoglobin level was significantly related to FEV1 (r = -0.18; P less than 0.001) and smoking habits. After adjustment for smoking, a history of wheezing was significantly related to lower haptoglobin level. A second survey conducted in 304 men of the original sample 5 years later confirmed that haptoglobin was related to FEV1 (r = -0.21; P less than 0.001) and that wheezing was significantly related to hypohaptoglobinaemia (lower decile; P = 0.04). Men who exhibited bronchial hyper-responsiveness to methacholine had haptoglobin levels 0.35 g/l higher than those who did not (P = 0.01). Haptoglobin level was unrelated to IgE level and skin prick tests. These results support the hypothesis of the role of inflammation in both lower lung function and bronchial hyper-responsiveness. They suggest that some heterogeneity exists within subjects with a history of wheezing.
Kauffmann
F
F
INSERM Unit 169, Villejuif, France.
Frette
C
C
Annesi
I
I
Oryszczyn
M P
MP
Dore
M F
MF
Neukirch
F
F
D000328:Adult; D001249:Asthma / Q000097:blood / Q000453:epidemiology; D016535:Bronchial Hyperreactivity / Q000097:blood* / Q000453:epidemiology; D001985:Bronchial Provocation Tests; D015897:Comorbidity; D005541:Forced Expiratory Volume; D006242:Haptoglobins / Q000032:analysis*; D006801:Humans; D006967:Hypersensitivity / Q000097:blood* / Q000453:epidemiology; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged; D009961:Orosomucoid / Q000032:analysis; D012135:Respiratory Sounds; D012907:Smoking; D000515:alpha 1-Antitrypsin / Q000032:analysis
D006242:Haptoglobins; D009961:Orosomucoid; D000515:alpha 1-Antitrypsin; D016210:Methacholine Chloride