[The antiulcer action of antidepressants. II. The effect of the antidepressants inkazan, azafen, and OF-743 in combination with arginine on ethanol-evoked damage to the gastric mucosa in rats].
Mucosal gastric damages in rats induced by intragastric ethanol introduction decreased considerably on the background of action of one of the antidepressants (asaphen, inkasan and OF-743) in combination with arginine. The combination OF-743 with arginine has the largest protective action, the least one--asaphen with arginine. A comparison of protective action of some antidepressants with action of antidepressants in combination with arginine revealed a tendency to more expressed antiulcerogenic effect in studied combinations.
Natsvlishvili
N A
NA
Samonina
G E
GE
Ashmarin
I P
IP
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001120:Arginine / Q000627:therapeutic use*; D002243:Carbolines / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects*; D010078:Oxazines / Q000627:therapeutic use; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D013558:Sydnones / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D002243:Carbolines; D010078:Oxazines; D013558:Sydnones; C072808:OF 743; C100161:azaphen; C027473:metralindole; D000431:Ethanol; D001120:Arginine
Protivoiazvennoe deĭstvie nekotorykh antidepressantov. II, Vliianie antidepressantov inkazana, azafena i OF-743 v kombinatsii s argininom na vyzvannye étanolom povrezhdeniia slizistoĭ obolozhki zheludka krys.