title: [Alloimmune neutropenia in newborns].
abstract: Investigations were conducted in 4 infants with alloimmune neutropenia caused by leuko-agglutinins (2 cases) and granulo-cytotoxins (2 cases) detected in the mothers' and infants' sera. Anti-granulocytic antibodies reacted with granulocytes of the child and father but did not react with the mother's own cells. A more severe clinical course (repeated pyo-inflammatory diseases, sepsis) was recorded in infants with alloimmune neutropenia caused by granulo-cytotoxins, alloimmune neutropenia was characterized by disorders in neutrophil phagocytic activity (mainly, due to decreased digestive capacity of cells), inhibition of colony-forming capacity of precursor-cells of granulocytopoiesis; a tendency to T-lymphocytopenia was noted during the study of cellular immunity parameters. Prognosis was favourable in all the cases of neutropenia. The maximum term of neutropenia duration was 6 months. The catamnesis has shown that the development of the infants is normal and they fall ill not often.
authors.forename: N S
authors.initials: NS
authors.lastname: Kisliak
authors.forename: E A
authors.initials: EA
authors.lastname: Mamedova
authors.forename: N A
authors.initials: NA
authors.lastname: Finogenova
authors.forename: L P
authors.initials: LP
authors.lastname: Poreshina
authors.forename: M N
authors.initials: MN
authors.lastname: Vasil'eva
authors.forename: L P
authors.initials: LP
authors.lastname: Gerasimova
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D009503:Neutropenia / Q000276:immunology*
vernacular_title: Alloimmunnaia neĭtropeniia novorozhdennykh.