title: Trophoblast immunity in human pregnancy defined by antiidiotype.
abstract: Successful reproduction in mammals requires the mother to immunologically accept genetically disparate tissues. Allotypic trophoblast antigens (TLX) are thought to be responsible for influencing maternal acceptance of the feto-placental graft, and faulty regulation of immunity to TLX antigens has been associated with recurrent pregnancy losses. In this report, rabbit antiidiotype (RAb2) was produced to a human TLX antibody (Ab1). This RAb2 detected TLX cross-reactive idiotypes (CRI) on antitrophoblast IgG from women with normal and abnormal pregnancies. These findings support an hypothesis that women respond immunologically to allotypic trophoblast antigens, and that idiotype-antiidiotype regulation of this response is characteristic of normal pregnancy.
authors.affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts.
authors.forename: D S
authors.initials: DS
authors.lastname: Torry
authors.forename: W P
authors.initials: WP
authors.lastname: Faulk
authors.forename: J A
authors.initials: JA
authors.lastname: McIntyre
mesh_terms: D000022:Abortion, Spontaneous / Q000276:immunology; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D000918:Antibody Specificity; D001667:Binding, Competitive; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D011247:Pregnancy / Q000276:immunology*; D014327:Trophoblasts / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G