Association of a thyrotropin-secreting pituitary adenoma and a thyroid follicular carcinoma.
The different factors involved as etiological agents in thyroid cancer have in common long term thyroid follicle stimulation. On this base, a patient with a TSH-producing pituitary adenoma could be at high risk for developing thyroid cancer. A patient consulting for a single thyroid nodule was studied in our unit. He was diagnosed as having a TSH-producing pituitary adenoma and the Thyroid nodule was shown to be a follicular carcinoma following removed. We speculate that elevated TSH levels could have contributed to neoplastic transformation of the thyroid in this patient.
Calle-Pascual
A L
AL
Unidad de Endocrinologia y Nutricion, Hospital Ntra Sra de Sonsoles, Avila, Spain.
Yuste
E
E
Martin
P
P
Aramendi
T
T
Garcia-Mauriño
M L
ML
Argente
J
J
Catalan
M J
MJ
Uria
J
J
Cabranes
J A
JA
Charro
A L
AL
D000230:Adenocarcinoma / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D000236:Adenoma / Q000150:complications* / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging; D002230:Carbidopa / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D013006:Growth Hormone / Q000494:pharmacology; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007328:Insulin / Q000494:pharmacology; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D011388:Prolactin / Q000097:blood; D011863:Radioimmunoassay; D013964:Thyroid Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014284:Triiodothyronine / Q000097:blood
D007328:Insulin; D014284:Triiodothyronine; D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D002230:Carbidopa; D013974:Thyroxine; D006854:Hydrocortisone