title: Fat-soluble vitamins in infants identified by cystic fibrosis newborn screening.
abstract: Fat-soluble vitamin status was assessed in 36 infants diagnosed with cystic fibrosis by newborn screening in the Colorado Program. At the time of diagnosis of cystic fibrosis, 36% of infants were hypoalbuminemic, 21% had vitamin A deficiency, 35% had vitamin D deficiency, and 38% had vitamin E deficiency. None had vitamin K deficiency. Supplementation with pancreatic enzymes, a multiple vitamin preparation, and additional vitamin E was associated with normalization of serum albumin, retinol, and 25-hydroxyvitamin D and negative PIVKA testing at age 6 and 12 months. Several patients remained vitamin E deficient, but this was felt to be due to poor compliance. Biochemical evidence of fat-soluble vitamin deficiency is common before age 3 months in infants with CF and responds to supplementation in the first year of life.
authors.affiliation: Department of Pediatric Gastroenterology and Nutrition, University of Colorado Health Sciences Center, Denver.
authors.forename: R J
authors.initials: RJ
authors.lastname: Sokol
authors.forename: M C
authors.initials: MC
authors.lastname: Reardon
authors.forename: F J
authors.initials: FJ
authors.lastname: Accurso
authors.forename: C
authors.initials: C
authors.lastname: Stall
authors.forename: M R
authors.initials: MR
authors.lastname: Narkewicz
authors.forename: S H
authors.initials: SH
authors.lastname: Abman
authors.forename: K B
authors.initials: KB
authors.lastname: Hammond
mesh_terms: D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015997:Neonatal Screening; D010194:Pancreatin / Q000627:therapeutic use; D014802:Vitamin A Deficiency / Q000188:drug therapy / Q000209:etiology*; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000209:etiology*; D014810:Vitamin E / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000188:drug therapy / Q000209:etiology*; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D014815:Vitamins; D014810:Vitamin E; D010194:Pancreatin