[Immunogenetic grounds for the development of local forms of primary tuberculosis in children].
The ++clinico-immunogenetic status of children with local forms of primary tuberculosis was analysed. Examination included 99 children aged 4-14 years with pulmonary tuberculosis. The control group comprised 51 children who has negative tuberculin tests and no intercurrent diseases. The HLA composition was determined by the A, B, C and DR loci. The HLA-DR2 representation is responsible for a high specific process risk and HLA-A11 and HLA-B15 can be characterized as antigens causing a resistance to tuberculosis infection.
Vasil'ev
A V
AV
Dovgaliuk
I F
IF
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D015234:HLA-A Antigens / Q000235:genetics* / Q000276:immunology; D059870:HLA-A11 Antigen; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D059910:HLA-B15 Antigen; D015802:HLA-DR2 Antigen / Q000235:genetics* / Q000276:immunology; D006801:Humans; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000209:etiology* / Q000235:genetics / Q000276:immunology
D015234:HLA-A Antigens; D059870:HLA-A11 Antigen; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D015802:HLA-DR2 Antigen
Immunogeneticheskie predposylki razvitiia lokal'nykh form pervichnogo tuberkuleza u deteĭ.