title: Infectious gastroenteritis does not act as a triggering mechanism for the synthesis of serum IgG antibody to beta-lactoglobulin.
abstract: beta-Lactoglobulin (BLG)-specific serum IgG antibody was measured by enzyme-linked immunosorbent assay in 1,392 serum samples from newborn to 5-year-old Ecuadorian children enrolled into a representative nutrition and health survey. At a 1:100 serum dilution, 62% of the children showed specific antibody (blank-corrected optical density greater than or equal to 0.1). This prevalence did not change with increasing age. More specifically, we did not observe a prevalence or titer increase of BLG-specific antibody in age groups where the majority of these Ecuadorian children experienced infection with rotavirus (8-24-month age groups) and enterotoxigenic Escherichia coli (8-12-month age group). In addition, BLG-specific antibody did not differ between children who did or did not experience an episode of diarrhea 15 days before blood sampling. We observed a small but statistically significant difference in BLG-specific antibody between subsamples of Ecuadorian children regularly or only occasionally ingesting milk. Titers were higher in the group consuming more milk.
authors.affiliation: Nestlé Research Centre, Nestec Ltd., Lausanne, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Brüssow
authors.forename: J
authors.initials: J
authors.lastname: Sidoti
authors.forename: H
authors.initials: H
authors.lastname: Rahim
authors.forename: H
authors.initials: H
authors.lastname: Dirren
authors.forename: W
authors.initials: W
authors.lastname: Freire
mesh_terms: D000328:Adult; D000818:Animals; D001782:Blood Donors; D002648:Child; D002675:Child, Preschool; D004484:Ecuador; D004797:Enzyme-Linked Immunosorbent Assay; D004927:Escherichia coli Infections / Q000276:immunology*; D005260:Female; D005759:Gastroenteritis / Q000276:immunology*; D005858:Germany; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D007782:Lactoglobulins / Q000276:immunology*; D008297:Male; D008892:Milk; D012400:Rotavirus Infections / Q000276:immunology*; D012424:Rural Population; D014505:Urban Population
chemical_list: D007074:Immunoglobulin G; D007782:Lactoglobulins