[The bronchodilating effect of pirenzepine].
The purpose of this study was to clarify the bronchodilating effect of pirenzepine (PZ) and to verify its mechanism. Ten asthmatic patients (6 men, 4 women: aged 20 to 65, 5 atopic 5 non-atopic) and ten non-asthmatic volunteers (8 men, 2 women: aged 25 to 60) were studied. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1.0) and peak expiratory flow rate (PEFR) were measured after intravenous administration of 20 mg PZ. PZ increased FVC, FEV1.0 and PEFR significantly by 15%, 29% and 37% respectively in asthmatic patients (p less than 0.01). We also studied the effects of PZ on the contractile responses of tracheal smooth muscle to intra-arterially administered acetylcholine (ACh) and the electrical stimulation of the vagus nerves (VNS) using isometric technique in situ in 5 mongrel dogs. PZ significantly inhibited the contractile responses elicited with ACh at doses larger than 1000 micrograms/kg (p less than 0.01). PZ also significantly inhibited the contractile responses elicited by VNS at doses larger than 100 micrograms/kg (p less than 0.01). These data demonstrate that intravenously administered PZ dilates the airway in asthmatic patients and also suggest that the bronchodilating effect of PZ related to inhibition of the M1 and M3 muscarinic receptors.
Shioya
T
T
Second Department of Internal Medicine, Akita University School of Medicine.
Kagaya
M
M
Onodera
A
A
Miura
S
S
Miura
K
K
Miura
M
M
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000328:Adult; D000368:Aged; D000818:Animals; D001249:Asthma / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D010890:Pirenzepine / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects; D014797:Vital Capacity / Q000187:drug effects
D001993:Bronchodilator Agents; D018727:Muscarinic Antagonists; D010890:Pirenzepine; D000109:Acetylcholine