Effect of an interferon inhibitor on the antiproliferative signal of interferon-alpha.
We have described a nonantibody type inhibitor of interferons (IFN) in the blood of patients with AIDS, advanced neoplastic disorders, and lupus erythematosus in earlier reports (1,2). In the present study we show that the semipurified inhibitor blocks the antiproliferative signal of IFN-alpha in Daudi cells and the membrane potential shifting ability of IFN-alpha is modulated by the interferon inhibitor preparation (IFI).
Aszalos
A
A
Division of Research and Testing, Food and Drug Administration, Washington, D.C. 20204.
Chadha
K C
KC
Stadler
I
I
Ambrus
J L
JL
Ambrus
J L
JL
D002455:Cell Division / Q000187:drug effects; D006801:Humans; D016898:Interferon-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D008564:Membrane Potentials / Q000187:drug effects; D014407:Tumor Cells, Cultured
D016898:Interferon-alpha