Birdshot retinochoroidopathy and HLA-A29+ and HLA-A29- idiopathic retinal vasculitis: comparative study of 56 cases.
We reviewed the records of 20 patients with birdshot retinochoroidopathy and 36 patients with idiopathic retinal vasculitis. The numbers of patients with the HLA-A29 phenotype were 19 (95%) and 22 (61%) respectively. Overall, similar findings were noted in the birdshot retinochoroidopathy group and the HLA-A29+ idiopathic vasculitis group: more posterior pole involvement, more severe course and poor visual prognosis despite intense corticosteroid therapy. In contrast, the patients with HLA-A29- idiopathic vasculitis showed more peripheral involvement, the course was less severe and the prognosis was better; smaller amounts of steroids were used. Only one patient with HLA-A29+ idiopathic vasculitis eventually presented with signs of birdshot retinochoroidopathy; complete cure was obtained in other cases. Our results suggest the existence of an HLA-A29 syndrome encompassing birdshot retinochoroidopathy as well as other conditions whose expression would be determined genetically.
Bloch-Michel
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Unité d'Immunopathologie Oculaire, Centre Hospitalo-universitaire de Bicêtre, Faculté de Médecine, Paris Sud, France.
Frau
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D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D002825:Chorioretinitis / Q000175:diagnosis / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D005260:Female; D005451:Fluorescein Angiography; D015234:HLA-A Antigens / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D012171:Retinal Vessels; D013577:Syndrome; D014657:Vasculitis / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000628:therapy; D014821:Vitrectomy
D000305:Adrenal Cortex Hormones; D015234:HLA-A Antigens; C035524:HLA-A29 antigen; D007166:Immunosuppressive Agents