Comparison of continuous, constant rate enteral tube feeding in supine patients to bolus food intake in ambulatory, healthy subjects regarding bioavailability of perorally administered cefroxadine.
Stabilized, bedridden, inactive trauma patients on enteral nutrition via continuous, constant rate tube feeding (2 different formulas) were given a single dose of cefroxadine p.o. There were no differences in the pharmacokinetic parameters between the groups on different enteral nutrition. These patients were compared to cefroxadine absorption in ambulatory healthy subjects after a standardized meal (bolus-fed). The mean residence time was significantly longer in the patients, and the extent of absorption was slightly reduced with one enteral nutrition formulation and significantly reduced with the other. The other pharmacokinetic parameters were not significantly different. The difference is believed to be caused by reduction in splanchnic blood flow in the immobilized patients, weakening of migrating motor complex due to tube feeding and the lower temperature (4 degrees C) of enteral nutrition.
Beyssac
E
E
Biopharmaceutics Department, Faculty of Pharmacy, Clermont-Ferrand, France.
Ritschel
W A
WA
Aiache
J M
JM
Haberer
J P
JP
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D002515:Cephradine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004435:Eating; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D007103:Immobilization; D008297:Male; D009043:Motor Activity
C012671:cefroxadine; D002515:Cephradine