Membrane stabilising properties of the selective 5-HT2 receptor agonist, (+/-)-DOI.
The effects of (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a selective 5-HT2 receptor agonist, on nerve conduction in the isolated frog sciatic nerve trunk were examined. Compound action potential amplitude was concentration dependently decreased by (+/-)-DOI (EC50 = 1.2 mM), an effect that was not altered by the presence of ketanserin and with a similar potency to lignocaine. (+/-)-propranolol and disopyramide. The results indicate that (+/-)-DOI has membrane stabilising properties, in addition to its reported 5-HT2 agonist actions.
Martin
K F
KF
Boots Pharmaceuticals Research Department, Nottingham, U.K.
Kellett
R
R
Buckett
W R
WR
D000200:Action Potentials / Q000187:drug effects; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D004206:Disopyramide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D009431:Neural Conduction / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D011896:Rana temporaria; D012584:Sciatic Nerve / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology*
D000662:Amphetamines; D012702:Serotonin Antagonists; D008012:Lidocaine; D011433:Propranolol; D004206:Disopyramide; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine