title: Isoenzyme changes in Candida albicans during domestication.
abstract: Isoenzyme analysis was performed on multiple strains of two commonly used reference cultures of Candida albicans (B311 and NCPF3153). Whereas strains originating from C. albicans B311 showed no variation in isoenzyme profiles, some strains derived from NCPF3153 were identical to B311 strains but others showed variation in their glucose-6-phosphate dehydrogenase isoenzymes. The results are compared with those from previous analyses with these strains and show that C. albicans can undergo genetic alterations during prolonged maintenance in laboratories.
authors.affiliation: Department of Microbiology, Medical College of Ohio, Toledo 43699-0008.
authors.forename: P F
authors.initials: PF
authors.lastname: Lehmann
authors.forename: L C
authors.initials: LC
authors.lastname: Wu
authors.forename: D W
authors.initials: DW
authors.lastname: Mackenzie
mesh_terms: D002176:Candida albicans / Q000145:classification / Q000201:enzymology* / Q000235:genetics; D014644:Genetic Variation; D007527:Isoenzymes / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D009172:Mycology / Q000379:methods; D012015:Reference Standards; D013045:Species Specificity
chemical_list: D007527:Isoenzymes