Deconvolution method for accurate determination of overlapping peak areas in chromatograms.
A method is described for deconvoluting chromatograms which contain overlapping peaks. Parameters can be selected to ensure that attenuation of peak areas is uniform over any desired range of peak widths. A simple extension of the method greatly reduces the negative overshoot frequently encountered with deconvolutions. The deconvoluted chromatograms are suitable for integration by conventional methods.
Nelson
T J
TJ
Neural Systems Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892.
D002845:Chromatography / Q000379:methods*; D008433:Mathematics