title: Sedative effect of detomidine in infant calves.
abstract: Detomidine administered intramuscularly at a dose of 10, 20 or 40 micrograms/kg body mass was evaluated for its sedative effects in 15 unfasted infant calves (age: 15-20 days; body mass: 18-33 kg). The drug produced dose-dependent sedation. At a dose of 10 micrograms/kg detomidine produced effective sedation for 30 to 45 min without any observable analgesia. At doses of 20 or 40 micrograms/kg it caused deep sedation, sternal recumbency, and moderate analgesia of the trunk. Hyperglycaemia was recorded at all dose levels. The changes in respiratory rate, rectal temperature, haemoglobin, packed cell volume, total erythrocyte count and plasma concentration of total protein were not significant.
authors.affiliation: Department of Veterinary Surgery and Radiology, College of Veterinary Sciences, Haryana Agricultural University, Hisar, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Peshin
authors.forename: A P
authors.initials: AP
authors.lastname: Singh
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: D B
authors.initials: DB
authors.lastname: Patil
authors.forename: D
authors.initials: D
authors.lastname: Sharifi
mesh_terms: D000698:Analgesia / Q000662:veterinary; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002417:Cattle / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C041255:detomidine