The nephropathology in human immunodeficiency virus (HIV-1) infection.
The nephropathology observed in patients with HIV infection is reviewed. A characteristic, though not specific, nephropathy associated with HIV infection can be encountered in HIV carriers, in patients with AIDS-related complex and in patients with AIDS. HIV-associated nephropathy typically exhibits the features of an aggressive form of focal and segmental glomerulosclerosis. Distinctive pathologic features include: 1) the "collapsing" and predominantly global pattern of glomerulosclerosis; 2) the severity of visceral epithelial cell hypertrophy and droplet formation; 3) the prominent tubular microcysts and cast formation; 4) the focal tubular degenerative features; and 5) the numerous tubuloreticular inclusions.
Bourgoignie
J J
JJ
Department of Medicine, University of Miami School of Medicine, Florida.
Pardo
V
V
D016263:AIDS-Associated Nephropathy / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology; D015658:HIV Infections / Q000473:pathology*; D015497:HIV-1; D006801:Humans; D007668:Kidney / Q000473:pathology*