title: [A comparative study of nisoldipine and alpha-methyldopa in aged patients with isolated systolic hypertension].
abstract: A comparative, randomized and cross clinical trial between nisoldipine and alpha-methyldopa in 50 aged patients with isolated systolic hypertension during 12 weeks. The therapeutic aim (SAP less than or equal to 160 mmHg) was reached after the first period in the 60% of the patients treated with nisoldipine and the 63% of those who took alpha-methyldopa (ns), and after the second period: 77% in nisoldipine group and 82% for alpha-methyldopa (ns). Adverse effects were experienced in the 21.7% of the patients treated with nisoldipine and in the 60.8% of the patients who received alpha-methyldopa (p less than 0.001. Nisoldipine had a lower effect that alpha-methyldopa over the diastolic arterial pressure. It was not any change in the biochemical parameters related to both antihypertensive drugs.
authors.affiliation: Servicio de Geriatría, Hospital de la Cruz Roja, Madrid.
authors.forename: F
authors.initials: F
authors.lastname: Guillén Llera
authors.forename: J M
authors.initials: JM
authors.lastname: Reuss
authors.forename: F
authors.initials: F
authors.lastname: Sagués
authors.forename: N
authors.initials: N
authors.lastname: Tobares
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008750:Methyldopa / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015737:Nisoldipine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013599:Systole; D013997:Time Factors
chemical_list: D015737:Nisoldipine; D008750:Methyldopa
vernacular_title: Estudio comparativo entre nisoldipino y alfa-metildopa en pacientes ancianos con hipertensión sistólica aislada.