title: [Significance of therapeutic pathomorphosis in the treatment and prognosis of osteogenic sarcoma in children].
abstract: To decide the problem of adequacy of preoperative treatment and postoperative special therapy, it is necessary to determine the degree of therapeutic pathomorphosis of primary osteogenic sarcoma. According to the materials of the children's clinic of the All-Union Cancer Research Center, USSR AMS, the degree of impairment is dependent on the size of the neoplasm, nature of the treatment and the x-ray-morphological variant. In a group of patients given preoperative chemoradiation treatment for degrees III and IV of therapeutic pathomorphosis, the 5-year survival amounted to 37.9 and 67.2% of cases, respectively. In a weak degree of tumor lesion (I-II), only 7% of the patients survive the 5-year period without metastases. The degree of therapeutic pathomorphosis is of great importance for correcting postoperative therapy as well as for predicting the course of osteogenic sarcoma in children.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Pashkov
authors.forename: N M
authors.initials: NM
authors.lastname: Ivanova
authors.forename: A N
authors.initials: AN
authors.lastname: Fedenko
authors.forename: V I
authors.initials: VI
authors.lastname: Lebedev
authors.forename: R S
authors.initials: RS
authors.lastname: Ravshanova
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D011859:Radiography
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Znachenie terapevticheskogo patomorfoza v lechenii i prognoze osteogennoĭ sarkomy u deteĭ.