Randomized treatment of patients with typhoid and paratyphoid fevers using norfloxacin or chloramphenicol.
Forty adult patients with Salmonella typhi and S. paratyphi infections were studied in a randomly assigned prospective study to receive norfloxacin (12 drug-sensitive and 8 drug-resistant cases) or chloramphenicol (20 cases). No complication occurred in either group and no side effect was noted in the norfloxacin-treated group. The results suggest that a 7 d course of twice daily norfloxacin promises to be an alternative to a 14 d course of chloramphenicol for treating chloramphenicol-sensitive and multidrug-resistant typhoid and paratyphoid fevers.
Sarma
P S
PS
Department of Medicine, Jawaharlal Nehru Hospital and Research Centre, Bhilainagar, Madhya Pradesh, India.
Durairaj
P
P
D000293:Adolescent; D000328:Adult; D002701:Chloramphenicol / Q000009:adverse effects / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008297:Male; D009643:Norfloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D010284:Paratyphoid Fever / Q000188:drug therapy*; D011446:Prospective Studies; D014435:Typhoid Fever / Q000188:drug therapy*
D002701:Chloramphenicol; D009643:Norfloxacin