[The influence of melatonin, epiphysectomy and anaprilin on the cataleptogenic effect of haloperidol and its time dynamics].
The acute administration of the pineal hormone melatonin (1 mg/kg) to rats was shown to increase, and the chronic use to decrease intensity of haloperidol-induced catalepsy with the reorganization of the rhythmic pattern of the neuroleptic effect. The direct opposite shifts were observed after pinealectomy or propranolol chronic administration (1 mg/kg). It is suggested that owing to its own adaptive properties the pineal gland can participate in the formation of drug tolerance.
Arushanian
E B
EB
Binatova
N Iu
NIu
Popov
A V
AV
Popova
A P
AP
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced* / Q000503:physiopathology; D004347:Drug Interactions; D006220:Haloperidol / Q000633:toxicity*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010870:Pineal Gland / Q000187:drug effects / Q000502:physiology* / Q000601:surgery; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012621:Seasons; D013997:Time Factors
D011433:Propranolol; D006220:Haloperidol; D008550:Melatonin
Vliianie melatonina, épifizéktomii i anaprilina na kateleptogennyĭ éffekt galoperidola i ego vremennúiu dinamiku.