Concomitant Creutzfeldt-Jakob and Alzheimer diseases.
We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identified by Western blot analysis of brain extracts.
Powers
J M
JM
Department of Pathology, Columbia-Presbyterian Medical Center, New York, NY.
Liu
Y
Y
Hair
L S
LS
Kascsack
R J
RJ
Lewis
L D
LD
Levy
L A
LA
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001284:Atrophy / Q000473:pathology; D015153:Blotting, Western; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001923:Brain Chemistry; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D014057:Tomography, X-Ray Computed
D016229:Amyloid beta-Peptides