[Pharmacokinetics of norethindrone enanthate 200 mg after intramuscular injection in 25 Chinese women].
Pharmacokinetic profile was studied in 25 healthy fertile Chinese female volunteers after im norethindrone enanthate (NET-EN) 200 mg. The results were compared with the data from British women in our previous paper. Following a single im NET-EN 200 mg, the times to reach peak levels of NET-EN and NET were 4.0 +/- 2.8 d and 5.4 +/- 2.0 d, and their peak values were 5.0 +/- 1.8 and 12.6 +/- 0.9 ng.ml-1, respectively. Mean elimination T1/2 of NET was significantly longer than that of NET-EN. Mean apparent elimination T1/2 were 14.8 +/- 3.8 d for and 11.4 +/- 5.7 d for NET-EN. The elimination rate of NET in Chinese women was significantly slower than that in British women. There was no significant ethnic difference in absorption kinetics of NET and NET-EN.
Sang
G W
GW
Family Planning Research Institute, Zhejiang Academy of Medicine, Hangzhou, China.
Liu
X H
XH
Shao
Q X
QX
Ge
J L
JL
Mao
S M
SM
Lu
F Y
FY
D000328:Adult; D044466:Asian People; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D009640:Norethindrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D045167:Progesterone Congeners; D044465:White People
D045167:Progesterone Congeners; C024319:norethindrone enanthate; D009640:Norethindrone