Protein kinase C beta-subtype-immunoreactive motor and sensory nerves in rat muscle spindle.
The localization of protein kinase C beta-subtype-like immunoreactivity (PKC-beta-LI) was studied in the muscle spindles of rat neck muscles. In the equatorial regions of muscle spindles PKC-beta-LI was detected in spiral sensory nerve endings surrounding intrafusal muscle fibers. In polar regions single PKC-beta-immunoreactive (IR) nerve fibers were found between intrafusal muscle fibers and some PKC-beta-IR motor nerve endings were seen on the surface of intrafusal fibers. These results suggest that PKC-beta may be involved in regulation of muscle contraction and tonus by modulating the sensitivity of afferent and efferent innervation of muscle spindles.
Hietanen-Peltola
M
M
Department of Biomedical Sciences, University of Tampere, Finland.
Rechardt
L
L
Pelto-Huikko
M
M
D000818:Animals; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000032:analysis*; D008297:Male; D009046:Motor Neurons / Q000201:enzymology*; D009132:Muscles / Q000294:innervation*; D009469:Neuromuscular Junction / Q000201:enzymology*; D009475:Neurons, Afferent / Q000201:enzymology*; D011493:Protein Kinase C / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D007527:Isoenzymes; D011493:Protein Kinase C