Synthesis and evaluation of in vitro antitumor activity of some substituted 5-pyridazinyl-styrylketones.
A series of twenty pyridazinyl-styrilketones, substituted at position 4 with linear or cyclic tertiary amino groups, were synthesized and evaluated in vitro as antitumor agents against 60 human tumor cell-lines. Moderate activity and differential cell sensitivity were found for several of the compounds. Cell-line XF-498L (panel:Brain) showed differential cell sensitivity towards compound 5b (more than 1000 times the mean sensitivity of all cell-lines).
Ciciani
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Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università di Firenze.
Dal Piaz
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V
Giovannoni
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MP
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011355:Prodrugs; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013343:Styrenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D011355:Prodrugs; D011724:Pyridazines; D013343:Styrenes