[The effect of Bulbus allii on precancerous lesions of the esophagus due to N-methyl-N-amylnitrosamine in rats].
In so much as precancerous lesions of the esophagus are a stage that must pass in the course of formation of carcinoma of the esophagus, inhibiting its occurrence is an important measure in the prevention of esophageal. The test was carried out in 84 Wistar rats of both sexes randomly divided into 2 groups, one group fed with 50% aqueous extract of Bulbus allii and the other as control. After 105th day of experiment, results showed that Bulbus allii inhibited significantly precancerous lesions of the esophagus due to N-methyl-N-amyl-nitrosamine (P less than 0.05) increases of the splenic index (P less than 0.001) in rate and the percentage of peripheral T-lymphocyte (P less than 0.01) in rats. The results suggested that Bulbus allii had a preventive action against carcinoma of the esophagus, which could be attributed to increasing the immunity.
Cao
Z L
ZL
Xinxiang Medical College.
D000818:Animals; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005737:Garlic; D008297:Male; D009602:Nitrosamines; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011230:Precancerous Conditions / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology
D009602:Nitrosamines; D010936:Plant Extracts; C025033:N-amyl-N-methylnitrosamine