title: [Vitamin E and its structural analogs in tuberculosis].
abstract: Efficiency of tocopherol, its analog with a shortened side chain as well as their quinons for tuberculosis was determined. All the studied compounds inhibited peroxide-formation processes in the liver homogenate and mitochondria. The vitamin E amount in the blood is considerably decreased in case of tuberculosis. The studied analogs increased its content and possessed a weak tuberculostatic but expressed antiedemic and antiinflammatory action. Administration of vitamin E in combination with isoniazid to sick animals had a favourable effect on the processes of tissue respiration and oxidative phosphorylation. If taking a sum of characters, tocopherol acetate with a shortened side chain is the most efficient of all the analogs under study for the tuberculosis therapy.
authors.forename: A V
authors.initials: AV
authors.lastname: Panasiuk
authors.forename: O R
authors.initials: OR
authors.lastname: Penenko
authors.forename: I V
authors.initials: IV
authors.lastname: Kuz'menko
authors.forename: E I
authors.initials: EI
authors.lastname: Suslov
authors.forename: M T
authors.initials: MT
authors.lastname: Klimenko
authors.forename: N I
authors.initials: NI
authors.lastname: Kuznitsa
authors.forename: T A
authors.initials: TA
authors.lastname: Tumanova
authors.forename: V P
authors.initials: VP
authors.lastname: Makovetskiĭ
authors.forename: G V
authors.initials: GV
authors.lastname: Donchenko
mesh_terms: D000818:Animals; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D007538:Isoniazid / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011809:Quinones / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014810:Vitamin E / Q000031:analogs & derivatives / Q000627:therapeutic use*
chemical_list: D011809:Quinones; D014810:Vitamin E; D007538:Isoniazid
vernacular_title: Vitamin E i ego strukturnye analogi pri tuberkuleze.