title: The steroid hormone antagonist RU486. Mechanism at the cellular level and clinical applications.
abstract: The cellular and molecular mechanism of RU486, a steroid hormone antagonist, is discussed in detail. Principally, RU486 opposes the action of two types of hormones: progesterone and glucocorticosteroids. The clinical applications are also described, as well as the future outlook.
authors.affiliation: INSERM U 33 Lab Hormones, Bicêtre, France.
authors.forename: E E
authors.initials: EE
authors.lastname: Baulieu
mesh_terms: D000028:Abortion, Induced; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology* / Q000627:therapeutic use; D008969:Molecular Sequence Data; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D011980:Receptors, Progesterone / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism
chemical_list: D011965:Receptors, Glucocorticoid; D011980:Receptors, Progesterone; D015735:Mifepristone; D004247:DNA