Effects of nifedipine on normotensive rat placental blood flow, placental weight and fetal weight.
Recently, nifedipine (Ca antagonist) has been used for the treatment of preeclampsia. In this study, we investigated the effects of nifedipine on the normotensive Wistar Kyoto rat's placental blood flow, fetal weight and placental weight. We measured the rat's placental blood flow using clearance of hydrogen gas generated by electrolysis. The placental blood flow, placental and fetal weights of nifedipine-treated rats (5, 10 and 25 mg/kg) were significantly (p less than 0.05) reduced compared with normal pregnant rats. These data suggest that nifedipine might have some reducing effects on placental blood flow, fetal weight and placental weight.
Furuhashi
N
N
Department of Obstetrics and Gynecology, Tohoku University, School of Medicine, Sendai, Japan.
Tsujiei
M
M
Kimura
H
H
Yajima
A
A
D000818:Animals; D001724:Birth Weight / Q000187:drug effects*; D001783:Blood Flow Velocity / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004572:Electrolysis; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006859:Hydrogen; D009543:Nifedipine / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000033:anatomy & histology / Q000098:blood supply*; D010929:Placentation; D011225:Pre-Eclampsia / Q000188:drug therapy; D011247:Pregnancy; D051381:Rats; D011921:Rats, Inbred WKY
D006859:Hydrogen; D009543:Nifedipine