Receptors for angiotensins I and II: their relevance to renal haemodynamics, blood pressure control and hind-limb blood flow.
The well established differential pulmonary handling of angiotensins I and II indicates the possibility that vascular receptors for the deca- and octa-peptides do not necessarily involve common sites in the renal vasculature either. Experimental findings involving haemodynamic changes within the kidney in anaesthetised and conscious sheep, with utilization of the angiotensins, and also of noradrenaline, are briefly presented; the implications of the intra-renal water and creatinine transfers are discussed, especially as they concern the possible location of angiotensin receptors in the renal blood vessels. Other aspects of the relationships between the peptides are also taken into account particularly with regard to a postulated angiotensin I [NaCl] dependent peritubular capillary antidiuretic action, angiotensin converting enzyme inhibition, Goldblatt clamp induced hypertension and blood flow through the hind-limbs.
Osborn
E C
EC
Department of Renal Medicine, Southmead Hospital, Bristol, UK.
Fearn
L M
LM
Francis
R J
RJ
MacKenzie
J C
JC
Wilson
J
J
D000803:Angiotensin I / Q000502:physiology; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D008954:Models, Biological; D011945:Receptors, Angiotensin / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D012079:Renal Circulation / Q000502:physiology*; D012756:Sheep
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D000803:Angiotensin I