[Effects of mecobalamin on testicular dysfunction induced by X-ray irradiation in mice].
Experimental testicular dysfunction were produced by X-ray irradiation to the testes in mice. Mecobalamin (CH3-B12) was orally administered at a daily dose of 0.01, 0.1 or 1 mg/kg six times a week for 8 weeks from the next day after the irradiation. The control mice received physiological saline in the same manner. On 4th- and 6th-week after the irradiation, the weights of testes and epididymides were decreased, although those of the body and accessory sex glands (seminal vesicle, coagulating gland and prostate) were nearly equal to those of non-irradiated mice. At the same time, the diameter of seminiferous tubules decreased and sperm parameters (sperm count, sperm motility and sperm abnormality) deteriorated. When CH3-B12 (1 mg/kg) was administered, the diameter of seminiferous tubules increased and sperm parameters improved as compared to those of the control. The results indicate that CH3-B12 improved the experimental testicular dysfunction in mice induced by the irradiation. These results suggest that CH3-B12 might accelerate testicular function.
Oshio
S
S
Department of Urology, Teikyo University School of Medicine, Tokyo, Japan.
Yazaki
T
T
Umeda
T
T
Ozaki
S
S
Ohkawa
I
I
Tajima
T
T
Yamada
T
T
Mohri
H
H
D000284:Administration, Oral; D000818:Animals; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D013076:Sperm Count; D013081:Sperm Motility; D013091:Spermatogenesis; D013733:Testicular Diseases / Q000188:drug therapy* / Q000503:physiopathology; D013737:Testis / Q000503:physiopathology / Q000528:radiation effects*; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
C019476:mecobalamin; D014805:Vitamin B 12