[HLA class II DP antigens and bone marrow transplantation].
The biochemical structure of the HLA class II DP antigens is close to that of the remainder DR and DQ isotypes. Nevertheless, they may play a peculiar functional role. Their importance in bone marrow transplantation, where a complete HLA class II identity between graft donor and recipient is requested, is not yet known. The detection of a DP mismatch by using the mixed lymphocyte reaction is quite difficult. The role of such a mismatch in the incidence of graft versus host disease (GVHD) or graft rejection has to be defined. Studies on large series of recombinant families, using oligotyping, are necessary.
Urlacher
A
A
Centre de Transfusion sanguine, Strasbourg.
Bergerat
J P
JP
Cesbron
A
A
Bignon
J D
JD
Tongio
M M
MM
D016026:Bone Marrow Transplantation / Q000276:immunology*; D002478:Cells, Cultured; D006084:Graft Rejection / Q000276:immunology; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000276:immunology; D006682:HLA-DP Antigens / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology
D006682:HLA-DP Antigens
Antigènes HLA de classe II DP et greffe de moelle osseuse.