title: Prevalence of type I spinal muscular atrophy in North Dakota.
abstract: In order to establish the incidence and prevalence of type I spinal muscular atrophy (SMA Werdnig-Hoffmann disease) in North Dakota, we reviewed the death certificates for the past 8 years. Between 1980 and 1987 the prevalence of was 1.5 per 10,000. The incidence was 1 in 6,720. This suggests a carrier frequency of 1 in 41 in North Dakota with a gene frequency of 0.0122. In North Dakota, type I spinal muscular atrophy appears to be 3 to 10 times more common than in other locations.
authors.affiliation: Department of Neuroscience, School of Medicine, University of North Dakota, Grand Forks.
authors.forename: L
authors.initials: L
authors.lastname: Burd
authors.forename: S K
authors.initials: SK
authors.lastname: Short
authors.forename: J T
authors.initials: JT
authors.lastname: Martsolf
authors.forename: R A
authors.initials: RA
authors.lastname: Nelson
mesh_terms: D003644:Death Certificates; D005260:Female; D005787:Gene Frequency; D005808:Genes, Recessive; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D009658:North Dakota / Q000453:epidemiology; D010375:Pedigree; D015995:Prevalence; D014897:Spinal Muscular Atrophies of Childhood / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality