Synthesis and nootropic activity of 2-oxo-1-pyrrolidinesulfonic acid derivatives.
The synthesis of a series of 2-oxo-1-pyrrolidinesulfonic acid derivatives, as potential nootropic agents, is reported. Such compounds were designed to have chemical and physico-chemical properties intermediate between 2-oxo-1-pyrrolidineacetamides (e.g. oxiracetam) and 1-acyl-2-pyrrolidinones (e.g. aniracetam). The ability of these compounds to counteract the ECS-induced amnesia in mice was assessed in a one trial, step through, passive avoidance paradigm. Whilst oxiracetam and aniracetam confirmed their antiamnestic action, none of the title compounds showed a statistically significant activity.
Cerri
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A
Ist-Laboratori Per la Ricerca Biomedica (Milano), Italy.
Farina
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C
Pinza
M
M
Banfi
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S
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004597:Electroshock; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology
D011619:Psychotropic Drugs; D011759:Pyrrolidines; D011760:Pyrrolidinones; C073245:2-oxo-1-pyrrolidinesulfonic acid; C036466:aniracetam; C040619:oxiracetam