title: Neuropsychological probes of fronto-limbic system dysfunction in schizophrenia. Olfactory identification and Wisconsin Card Sorting performance.
abstract: Schizophrenic patients and normal control subjects took the University of Pennsylvania Smell Identification Test (UPSIT) and Wisconsin Card Sorting Test (WCST) as dual neuropsychological 'probes' of orbitofrontal (OF) and dorsolateral (DL) prefrontal function respectively. Patients were significantly impaired on both tasks compared to controls. UPSIT and WCST performance were uncorrelated in patients but were positively correlated in controls. The lack of correlation found in the patients suggests that the tasks may be tapping independent dysfunctions in schizophrenia reflecting differential impairment in fronto-limbic brain systems. Individual profiles of preserved and impaired performance on the UPSIT and WCST suggested that three schizophrenic patients had OF dysfunction, five had DL dysfunction and seven had a generalized (OF and DL) frontal system dysfunction. The reduced ability of schizophrenic patients to identify odors was largely independent of many deficits or confounds typically associated with schizophrenia and did not appear to be simply a function of generalized deficit. These data are preliminary and require replication with larger samples and validation with other measures of fronto-limbic system dysfunction.
authors.affiliation: Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, Boston 02115.
authors.forename: L J
authors.initials: LJ
authors.lastname: Seidman
authors.forename: N L
authors.initials: NL
authors.lastname: Talbot
authors.forename: A G
authors.initials: AG
authors.lastname: Kalinowski
authors.forename: R W
authors.initials: RW
authors.lastname: McCarley
authors.forename: S V
authors.initials: SV
authors.lastname: Faraone
authors.forename: W S
authors.initials: WS
authors.lastname: Kremen
authors.forename: J R
authors.initials: JR
authors.lastname: Pepple
authors.forename: M T
authors.initials: MT
authors.lastname: Tsuang
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology; D004193:Discrimination Learning / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008032:Limbic System / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology*; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012903:Smell / Q000502:physiology*