[Lectin-histochemical characteristics of the epithelium in intestinal metaplasia, polyps and cancer of the stomach].
Distribution of lectins (PNA, SBA, WGA, and Con A) has been studied in 53 stomach biopsies. Positive lectin reaction in the foveolar epithelium is observed, including dysplastic foci in the apical plasmalemma and in the cytoplasm around the nucleus this corresponding to the Golgi complex. It was mainly the apical plasmalemma of the columnar epithelium in the foci of intestinal metaplasia. Differences in the receptor localization were established in non-complete intestinal metaplasia, hyperplastic polyps and adenomas this depending on the cell type. Carcinoma cells not infrequently had all the plasmalemma stained with granules of the reaction product being distributed through all the cytoplasm. Lectin reactions are more pronounced in carcinomas accumulating mucus. Lectin binding by tumorous cells containing mucus was enhanced after the elimination of sialic acid as a result of the incubation with neuraminidase. Intensity of lectin reactions somewhat differs in various histological forms of stomach cancer.
Zolotarevskiĭ
V B
VB
Ufimtseva
A G
AG
D000230:Adenocarcinoma / Q000737:chemistry; D000231:Adenocarcinoma, Papillary / Q000378:metabolism; D000236:Adenoma / Q000737:chemistry; D000818:Animals; D004848:Epithelium / Q000737:chemistry; D005260:Female; D006651:Histocytochemistry; D006965:Hyperplasia / Q000378:metabolism; D007417:Intestinal Polyps / Q000378:metabolism*; D007422:Intestines / Q000737:chemistry / Q000473:pathology*; D037102:Lectins; D008297:Male; D008679:Metaplasia / Q000378:metabolism; D051379:Mice; D013274:Stomach Neoplasms / Q000378:metabolism*
D037102:Lectins
Lektino-gistokhimicheskaia kharakteristika épiteliia pri kishechnoĭ metaplazii, polipakh i rake zheludka.