Linkage of bipolar affective disorders to markers on chromosome 11p is excluded in a second lateral extension of Amish pedigree 110.
Linkage between markers on chromosome 11p and bipolar affective disorders can be excluded in a second large lateral extension of the original Amish Pedigree 110. These results, together with previous negative linkage findings, suggest that there is not one single gene on 11p conferring susceptibility for bipolar affective disorders among the Old Order Amish.
Pauls
D L
DL
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.
Gerhard
D S
DS
Lacy
L G
LG
Hostetter
A M
AM
Allen
C R
CR
Bland
S D
SD
LaBuda
M C
MC
Egeland
J A
JA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000208:ethnology / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes / Q000235:genetics; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011995:Recombination, Genetic / Q000235:genetics; D015183:Restriction Mapping
D015342:DNA Probes; D005819:Genetic Markers