Polarized sorting of GPI-linked proteins in epithelia and membrane microdomains.
Taken together, our results with endogenous and transfected GPI-anchored proteins (summarized in Table 6) suggest that covalent attachment to GPI functions as an apical transport signal in polarized epithelial cells. This is the first example of a well-defined targeting signal for the post-Golgi sorting of plasma membrane proteins in polarized epithelia; the only other known post-Golgi targeting signal is mannose-6-phosphate, which functions in the recognition of lysosomal hydrolases and directs them to lysosomes.
Lisanti
M P
MP
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021.
Rodríguez-Boulan
E
E
D000818:Animals; D002240:Carbohydrate Sequence; D002460:Cell Line; D016764:Cell Polarity; D017261:Glycosylphosphatidylinositols; D006595:Hexosamines / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008969:Molecular Sequence Data; D010716:Phosphatidylinositols / Q000378:metabolism*; D011134:Polysaccharides / Q000378:metabolism*
D017261:Glycosylphosphatidylinositols; D006595:Hexosamines; D008562:Membrane Glycoproteins; D010716:Phosphatidylinositols; D011134:Polysaccharides; C008322:mannosamine