title: Nimodipine in migraine: clinical efficacy and endocrinological effects.
abstract: Serum prolactin is increased during chronic flunarizine treatment of patients suffering from migraine. In order to clarify the role of calcium in control of the secretion of anterior pituitary hormones, a study has now been made of the effects of chronic nimodipine and propranolol treatment of migraine patients on prolactin (PRL), luteinizing hormone (LH) and growth hormone (GH) levels. 11 patients were treated with nimodipine and 8 with propranolol for four months. A statistically significant reduction in the frequency of the attacks was demonstrated in both groups. No significant change was found in the hormones levels during nimodipine treatment.
authors.affiliation: 1st Chair Department of Neurological Sciences, La Sapienza, University of Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Formisano
authors.forename: P
authors.initials: P
authors.lastname: Falaschi
authors.forename: R
authors.initials: R
authors.lastname: Cerbo
authors.forename: A
authors.initials: A
authors.lastname: Proietti
authors.forename: T
authors.initials: T
authors.lastname: Catarci
authors.forename: R
authors.initials: R
authors.lastname: D'Urso
authors.forename: C
authors.initials: C
authors.lastname: Roberti
authors.forename: V
authors.initials: V
authors.lastname: Aloise
authors.forename: F
authors.initials: F
authors.lastname: Chiarotti
authors.forename: A
authors.initials: A
authors.lastname: Agnoli
mesh_terms: D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D009553:Nimodipine / Q000494:pharmacology*; D010908:Pituitary Hormones, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D011433:Propranolol / Q000494:pharmacology
chemical_list: D010908:Pituitary Hormones, Anterior; D009553:Nimodipine; D011388:Prolactin; D007986:Luteinizing Hormone; D013006:Growth Hormone; D011433:Propranolol