Azathioprine for treatment of immune-mediated thrombocytopenia in two horses.
Azathioprine, a thiopurine antimetabolite used in the treatment of immune-mediated thrombocytopenia in human beings and dogs, was used in 2 cases of immune-mediated thrombocytopenia in horses that failed to respond to corticosteroid therapy alone. Platelet counts were increased to acceptable values in both horses. One horse returned to a successful racing career, and the other was euthanatized after developing renal disease and mild laminitis.
Humber
K A
KA
Department of Clinical Studies, George D. Widener Hospital, New Balton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348.
Beech
J
J
Cudd
T A
TA
Palmer
J E
JE
Gardner
S Y
SY
Sommer
M M
MM
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000662:veterinary*; D001379:Azathioprine / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000188:drug therapy / Q000662:veterinary*; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D003907:Dexamethasone; D001379:Azathioprine; D011241:Prednisone