[Influence of the speed of spheronization on the physical properties and dissolution availability of theophylline minigranules prepared by extrusion-spheronization].
From the minigranules of the theophylline-based that prepared by extrusion-spheronization, the authors have envisaged the study of one of the parameters of operation (spheronizer speed) on the physical properties and lyoavailability of the active ingredient. It emerges that there is a clear influence of that parameters on the particle size distribution, the hardness, the friability, the density and the lyoavailability.
Rahman
L
L
Université de Montpellier I, Faculté de Pharmacie, Laboratoire de Pharmacie Galénique, Pharmacotechnie et Biopharmacie.
Gaudy
D
D
Bataille
B
B
Jacob
M
M
Puech
A
A
D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods*; D011208:Powders; D012995:Solubility; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry*
D011208:Powders; D013806:Theophylline
Etude de l'influence de la vitesse de sphéronisation sur les propriétés physiques et la lyodisponibilité de minigranules de théophylline obtenus par extrusion-sphéronisation.