Effect of moniliformin on myocardial contractility in rats.
The present study was carried out on rat heart to in situ determine the myocardial toxicity of moniliformin, a synthesized compound, originally isolated from mouldy corn and soil samples in the Keshan disease prevalent area in China. Perfusion of moniliformin 10(-7) mol/liter in isolated heart decreased myocardial contractile force by 52 +/- 17%. Intravenous injection of moniliformin at 1/6 and 1/4 LD50 markedly inhibited cardiac hemodynamic variables relative to myocardial contractile function. Particularly, it decreased +/- LV dP/dt max by 52 +/- 6%, and induced ventricular arrhythmia. These data indicate that moniliformin is toxic to mammalian heart and might be an important factor relative to Keshan disease.
Fan
L L
LL
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Li
J
J
Sun
L H
LH
D000818:Animals; D003503:Cyclobutanes / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009183:Mycotoxins / Q000633:toxicity*; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D003503:Cyclobutanes; D009183:Mycotoxins; C008539:moniliformin