title: Volumetric analyses of central nervous system neoplasm based on MRI.
abstract: Morphometric analyses were performed using an objective semiautomated algorithm on 5 sequential three-dimensional T1-weighted magnetic resonance imaging scans of a metastatic choroid plexus carcinoma, concurrent with a course of chemotherapy. The 5 scans were positionally normalized in a three-dimensional coordinate system for uniform definition of the borders of the mass. Volumes were calculated for the gadolinium-DTPA enhancing and nonenhancing cystic-appearing regions. Volumetric changes of up to 145% were measured using this method which were associated with changes in the calculated (spherical) radii of only up to 2.7 mm. Volumetric changes of up to 59% were not appreciated by visual inspection, most probably due to irregular borders and positional variability across the scans. Volumetric analyses were also performed on the right cerebellar hemisphere, producing a 1.83% coefficient of variability across the 5 scans. The growth rates of this mass were estimated from the sequential computations, permitting in vivo observations on tumor behavior otherwise not obtainable. These analyses demonstrate the potential of this morphometric method to detect significant volumetric changes, and illustrate its use to define in vivo the growth properties of central nervous system tumors in response to therapeutic interventions.
authors.affiliation: Pediatric Neurology Service, Massachusetts General Hospital, Boston.
authors.forename: P A
authors.initials: PA
authors.lastname: Filipek
authors.forename: D N
authors.initials: DN
authors.lastname: Kennedy
authors.forename: V S
authors.initials: VS
authors.lastname: Caviness
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002277:Carcinoma / Q000175:diagnosis* / Q000188:drug therapy; D002675:Child, Preschool; D016545:Choroid Plexus Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D003287:Contrast Media; D003936:Diagnosis, Computer-Assisted; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA