No evidence of enterohepatic circulation of doxorubicin in a patient with transitory biliary obstruction due to lymphoblastic lymphoma.
Doxorubicin (DOX) and doxorubicinol (DOXOL) were analyzed by high performance liquid chromatography in serum, bile and urine in a lymphoma patient with tumor-induced biliary obstruction. The patient had an indwelling T-tube and was given DOX containing combination chemotherapy. The bile was collected via the T-tube and given orally (together with beer) to the patient four times daily. New samples were obtained three weeks later when normal bile flow was re-established. The serum and bile concentration curves for DOX and DOXOL show great similarity between the first and second chemotherapy course, respectively. This finding strongly argues against an enterohepatic circulation of DOX or DOXOL of clinical importance in man.
Engervall
P A
PA
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Björkholm
M J
MJ
Peterson
C O
CO
D001646:Bile / Q000737:chemistry / Q000378:metabolism; D002779:Cholestasis / Q000097:blood* / Q000209:etiology / Q000652:urine; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000097:blood* / Q000627:therapeutic use / Q000652:urine; D006801:Humans; D008102:Liver Circulation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000150:complications / Q000188:drug therapy
D004317:Doxorubicin; C010013:adriamycinol