Behavioural, electrocortical spectrum power and body temperature changes after microinfusion of some lymphokines in the rat brain.
Interleukin-1, interleukin-2 and interleukin-3 injected into the third cerebral ventricle produce typical behavioural sedation and/or sleep and ECoG synchronization in rats. Much smaller doses were required to produce similar behavioural and ECoG spectrum power effects after infusion of interleukins into the locus coeruleus. Interleukin-1 and interleukin-3 induced pyrogenic effects while interleukin-2 produced no pyrogenic actions. These effects were blocked by specific anti-interleukin receptors monoclonal antibodies. In addition, naloxone was able to antagonize the central effects of IL-2 but it did not affect the typical changes induced by IL-1. These results are consistent with the hypothesis that the behavioural, body temperature and ECoG changes of these lymphokines are mediated by specific receptors.
De Sarro
G
G
Department of Experimental and Clinical Medicine, School of Medicine, Catanzaro University of Reggio Calabria, Italy.
Nisticò
G
G
D000818:Animals; D000911:Antibodies, Monoclonal; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects*; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D007378:Interleukins / Q000008:administration & dosage / Q000494:pharmacology*; D008125:Locus Coeruleus / Q000187:drug effects / Q000502:physiology; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
D000911:Antibodies, Monoclonal; D007378:Interleukins; D011994:Recombinant Proteins; D009270:Naloxone