title: History of clinical trials.
abstract: Advances in medical treatments have occurred because of the application of new knowledge gained from clinical experiments conducted over the last 250 years. New sources of compounds with anti-tumor activity in human cancer are constantly under investigation. The development of a new drug is a complex process: screening, formulation, production, toxicology studies, FDA approval, and evaluation in phase I, II, and III clinical trials.
authors.affiliation: Cancer Nursing Service, National Institutes of Health, Bethesda, MD 20892.
authors.forename: J
authors.initials: J
authors.lastname: Jenkins
authors.forename: S
authors.initials: S
authors.lastname: Hubbard
mesh_terms: D000970:Antineoplastic Agents / Q000592:standards / Q000627:therapeutic use; D002985:Clinical Protocols / Q000592:standards; D002986:Clinical Trials as Topic / Q000266:history*; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D012106:Research / Q000266:history* / Q000458:organization & administration / Q000592:standards; D012107:Research Design / Q000592:standards; D014481:United States
chemical_list: D000970:Antineoplastic Agents