[Non-steroidal anti-inflammatory agents. XXII. Chiral aryl-hydroxy-fluorenylpropionic acids].
As fluorenyl rigid analogues of previous biphenylyl alcanoic acids with very interesting antiinflammatory activity, the 3-(m-tolyl and m-anisyl)-3-hydroxy-3-(2-fluorenyl)-propionic acids have been prepared by means of the Reformatsky reaction and following hydrolysis of the obtained ethyl esters. The preliminary antiinflammatory assay showed that the structural modification inactivates the compounds.
Burnelli
S
S
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Bologna.
Varoli
L
L
Guarnieri
A
A
Lumachi
B
B
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan / Q000037:antagonists & inhibitors; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005449:Fluorenes / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005449:Fluorenes; D002351:Carrageenan
Antiinfiammatori non steroidei. XXII--Acidi aril-idrossi-fluorenilpropionici chirali.