title: [Effects of l-stepholidine on isolated rabbit basilar artery, mesenteric artery, and thoracic aorta].
abstract: l-Stepholidine (SPD) has been shown to be effective in treating migraine, but its mechanism is not clear. So the effects of SPD on isolated rabbit basilar artery (BA), mesenteric artery (MA) and thoracic aorta (TA) were studied. The contractions of BA and MA were induced by KCl (10-160 mmol.L-1) and the contraction of TA was caused by 5-HT (0.1-100 mumol.L-1). Ketanserin was used as reference. SPD (0.1-0.2 mmol.L-1) relaxed the contractions of BA and MA induced by KCl in a noncompetitive manner with pD'2 3.4 +/- 0.3 and 4.0 +/- 0.3, respectively. SPD had no selectivity in BA and MA. SPD also inhibited the contraction of TA induced by 5-HT with pA2 9.7 +/- 2.0 and pD'2 5.4 +/- 0.6, which showed a dual of both competitive and noncompetitive antagonisms. These results suggested that SPD had a blockade effect on the calcium channel and 5-HT2 receptors.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Shanghat Medical University, China.
authors.forename: Y S
authors.initials: YS
authors.lastname: Miao
authors.forename: A Z
authors.initials: AZ
authors.lastname: Zhang
authors.forename: C
authors.initials: C
authors.lastname: Lin
authors.forename: M H
authors.initials: MH
authors.lastname: Jiang
authors.forename: G Z
authors.initials: GZ
authors.lastname: Jin
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001488:Basilar Artery / Q000187:drug effects; D001599:Berberine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008638:Mesenteric Arteries / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011817:Rabbits; D013237:Stereoisomerism
chemical_list: D001599:Berberine; C010513:stepholidine