title: In vitro brain acetylcholinesterase response among three inbred strains of mice to monocrotophos.
abstract: The strain differences in the neurotoxic potential of monocrotophos (MCP) were assessed by determining the inhibition of brain acetylcholinesterase (AChE) in BALB/cAnN, DBA/2J and C57BL/6J in vitro. MCP being a competitive inhibitor for AChE, alters the Km values widely among these inbred strains. Comparatively least alterations in Km were found in BALB/cAnN and maximum in DBA/2J. Based on the Ki values DBA/2J was found to be the most sensitive strain to MCP inhibition followed by C57BL/6J and BALB/cAnN.
authors.affiliation: Biology Division, Indian Institute of Chemical Technology, Hyderabad.
authors.forename: J V
authors.initials: JV
authors.lastname: Rao
authors.forename: A N
authors.initials: AN
authors.lastname: Swamy
authors.forename: S
authors.initials: S
authors.lastname: Yamin
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000378:metabolism; D008810:Mice, Inbred C57BL / Q000378:metabolism; D008811:Mice, Inbred DBA / Q000378:metabolism; D008815:Mice, Inbred Strains / Q000378:metabolism*; D008999:Monocrotophos / Q000633:toxicity*
chemical_list: D002800:Cholinesterase Inhibitors; D008999:Monocrotophos; D000110:Acetylcholinesterase