New surgical approach to overcome the inability of injured mammalian axons to grow within their environment.
We present a new method for creating conditions conductive to axonal growth in injured optic nerves of adult rabbits. The surgical approach consists of making a cavity in the adult rabbit optic nerve, into which a piece of nitrocellulose soaked with conditioned medium originating from regenerating fish optic nerves is implanted. In addition, daily irradiation (10 days, 5 min, 35 mW) with low energy He-Ne laser is carried out. Such a combined treatment may open a door to neurobiologists and clinicians, hoping to unravel the enigma of mammalian CNS regeneration.
Solomon
A
A
Goldschleger Eye Research Institute, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel.
Lavie
V
V
Ben-Bassat
S
S
Belkin
M
M
Schwartz
M
M
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D003101:Collodion; D003131:Combined Modality Therapy; D003470:Culture Media; D006054:Goldfish / Q000502:physiology*; D053685:Laser Therapy; D009416:Nerve Regeneration / Q000187:drug effects / Q000528:radiation effects; D009900:Optic Nerve / Q000187:drug effects / Q000528:radiation effects / Q000601:surgery; D020221:Optic Nerve Injuries; D019736:Prostheses and Implants; D011817:Rabbits
D003470:Culture Media; D003101:Collodion