[Parkinsonism induced by MPTP as an experimental model of Parkinson disease: similarities and differences].
MPTP administration, preferably to mice and primates, induces a selective damage of substantia nigra dopaminergic cells. Intrinsic mechanisms mediating MPTP induced toxicity, remain still under evaluation. There are very few semiological differences between Parkinson's disease (PD) and MPTP parkinsonism, but significant biochemical and neuropathological differences have been reported between these two entities. However, at the moment it represents the best model of Parkinson's disease available for the study of the basal ganglia function. In addition it could be a useful tool for a better understanding of mechanisms involved in neuronal death and regeneration. The present paper, summarize the real knowledge about the mechanism by which MPTP induces neuronal toxicity, the differences reported between PD and MPTP parkinsonism and finally its application for research.
Luquin
M R
MR
Departamento de Neurología, Facultad de Medicina, Universidad de Navarra, Pamplona.
Obeso
J A
JA
Herrero
M T
MT
Laguna
J
J
Martínez-Lage
J M
JM
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000009:adverse effects; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D020267:MPTP Poisoning; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010300:Parkinson Disease; D010302:Parkinson Disease, Secondary / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D011323:Primates; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine
Parkinsonismo inducido por MPTP como modelo experimental de enfermedad de Parkinson: similitudes y diferencias.