title: [Plasma cell leukemia: our experience in 4 cases].
abstract: Clinical findings and response to treatment in four cases with plasma cell leukemia (PCL) out of 152 patients of multiple myeloma diagnosed at the Hospital La Paz from 1969 to 1988 are studied. Three of the four plasma cell leukemia cases presented a primary form, and one a secondary form. Our cases had a lower incidence of lymphadenopathy and splenomegaly than reported in previous series. The incidence of serum M band in PCL was similar to that found in multiple myeloma. The four patients received combination chemotherapy; one of them attained PR lasting for 2 months, and the remaining three failed to respond to similar therapy. The mean duration of survival was less than 8 months. Current treatments are reviewed.
authors.affiliation: Servicio de Hematología, Hospital La Paz, Madrid.
authors.forename: F
authors.initials: F
authors.lastname: Manso
authors.forename: J L
authors.initials: JL
authors.lastname: Bello
authors.forename: J
authors.initials: J
authors.lastname: Feliu
authors.forename: J
authors.initials: J
authors.lastname: García de Bustos
authors.forename: G
authors.initials: G
authors.lastname: Losada
authors.forename: E
authors.initials: E
authors.lastname: Quevedo
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D011241:Prednisone / Q000627:therapeutic use; D012074:Remission Induction; D013713:Teniposide / Q000627:therapeutic use
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D013713:Teniposide; D011239:Prednisolone; D008558:Melphalan; D011241:Prednisone
vernacular_title: Leucemia de células plasmáticas: nuestra experiencia de cuatro casos.