title: [Ultrastructural alterations in rat brain tissues under the direct action of Escherichia coli endotoxin].
abstract: The experiments on the rats with intracisternal injection of endotoxin have revealed essential differences in the mechanisms of its permeability through cerebrospinal fluid-brain and blood-cerebrospinal fluid barriers. As for ependymal cells, endotoxin shunts through the cytoplasm in the areas of tight junctions and then it reaches perineuronal spaces. The mechanism of endotoxin penetration through the epithelium of choroid plexi is associated with receptor-mediated endocytosis.
authors.forename: E A
authors.initials: EA
authors.lastname: Bardakhch'ian
authors.forename: N G
authors.initials: NG
authors.lastname: Kharlanova
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D002946:Cisterna Magna; D004731:Endotoxins / Q000493:pharmacokinetics / Q000494:pharmacology*; D004805:Ependyma / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D004926:Escherichia coli; D007267:Injections; D008297:Male; D010539:Permeability; D051381:Rats
chemical_list: D004731:Endotoxins; C044101:endotoxin, Escherichia coli
vernacular_title: Ul'trastrukturnye izmeneniia v tkaniiakh golovnogo mozga krys pri priamom deĭstvii éndotoksina kishechnoĭ palochki.