[Diagnosis using monoclonal antibody imaging in the clinical follow-up of colorectal cancer].
A total of 44 patients with a range of ages between 34 and 72 were studied by immunoscintigraphy. They have surgical treatment for colon and rectum carcinomas. The immunoradiotracer used was a cocktail of F(ab')2 monoclonal-antibodies anti-CEA and CA 19.9. Planar images were obtained 4th, 6th, and 10th days postinjection. In some cases we used digital subtraction of image. Both CEA and CA 19.9 tumor markers were measured in patients serum. The method shows a global high sensitivity (88%), and specificity (92%).
Campos Villarino
L M
LM
Servicio de Medicina Nuclear, Hospital del Meixoeiro, Insalud, Vigo.
Pajares Vinardell
M
M
Freire Macias
J M
JM
Vale Gonsalves
E I
EI
Millán Núñez-Cortés
J
J
Senra Varela
A
A
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis* / Q000276:immunology; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000032:analysis* / Q000276:immunology; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D013382:Subtraction Technique
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D007140:Immunoglobulin Fab Fragments
Diagnóstico por imagen con anticuerpos monoclonales en el seguimiento clínico del cáncer colorrectal.