title: [The formation of an immune response in volunteers inoculated with a live recombinant influenza vaccine].
abstract: The capacity of a live influenza vaccine (LIV) to stimulate cytotoxic cells (ADCMC and NK) was studied in 49 volunteers and 56 patients with influenza. Experimental batches of LIV from influenza A and B viruses prepared by genetic recombination on the basis of cold-adapted attenuation donors were used. Type A and B LIV were shown to stimulate the cytotoxic cell-mediated and humoral immunity; the intensity of immune response, however, depended on the molecular genetic characteristics of the vaccine (genome structure, properties of the donor of attenuation), its biological activity and capacity of reproduction in tissues.
authors.forename: K V
authors.initials: KV
authors.lastname: Vorob'ev
authors.forename: L G
authors.initials: LG
authors.lastname: Rudenko
authors.forename: I T
authors.initials: IT
authors.lastname: Islamova
authors.forename: E P
authors.initials: EP
authors.lastname: Grigor'eva
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Egorov
authors.forename: T A
authors.initials: TA
authors.lastname: Ermachenko
authors.forename: E B
authors.initials: EB
authors.lastname: Chepik
authors.forename: N G
authors.initials: NG
authors.lastname: Zakharova
authors.forename: A M
authors.initials: AM
authors.lastname: Karachentsev
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D006389:Hemagglutinins, Viral / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control; D007694:Killer Cells, Natural / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D006389:Hemagglutinins, Viral; D007252:Influenza Vaccines; D014614:Vaccines, Synthetic
vernacular_title: Formirovanie immunnogo otveta u dobrovol'tsev, privitykh zhivoĭ grippoznoĭ rekombinantnoĭ vaktsinoĭ.