[Expression of c-myc and HER-1 genes in the development of human esophageal cancer].
To understand the possible role of oncogenes in the development of human esophageal cancer, the expression of c-myc and HER-1 genes was studied by in situ hybridization. The results showed that: (a) The c-myc and HER-1 protooncogenes were transcriptionally activated (b) Activation of c-myc gene was observed in hyperplastic cells and carcinoma cells. (c) The degree of pathological changes of the esophageal epithelium was related to the level of c-myc transcription, the highest level of c-myc expression was seen in invasive carcinoma cells. (d) Expression of HER-1 gene in carcinoma cells is higher than that in normal and adjacent non-tumor cells, but its frequency is lower than that of c-myc gene.
Liang
Y Y
YY
Cancer Institute, CAMS, Beijing.
D004938:Esophageal Neoplasms / Q000235:genetics*; D004947:Esophagus / Q000473:pathology; D016259:Genes, myc; D006801:Humans; D006965:Hyperplasia / Q000235:genetics; D011230:Precancerous Conditions / Q000235:genetics; D011519:Proto-Oncogenes