title: [Chronic lymphatic leukemia. II. Analysis of prognostic factors and development of survival predicting models. Study of 187 patients].
abstract: The univariate analysis of prognostic factors showed the value of clinical variables (age, symptoms, lymph node enlargement, splenomegaly, hepatomegaly, clinical stage), haematological variables (haemoglobin, platelet count, leucocyte count, lymphocyte count, bone marrow involvement and biopsy pattern, cleaved lymphocytes, prolymphocytes, LDT) and biochemical variables (BUN, creatinine, calcium, phosphorus, uric acid and albumin). The multivariate analysis chose the combination of Rai's stage, age, cervical lymph node involvement, phosphorus and BUN. Two predictive models capable of separating appropriately low, intermediate and high risk groups were developed and validated. The results were compared with others in the literature. The interest of predictive models arising from multivariate analysis is stressed.
authors.affiliation: Hospital Universitario La Fe, Valencia.
authors.forename: I
authors.initials: I
authors.lastname: Jarque
authors.forename: G
authors.initials: G
authors.lastname: Sanz
authors.forename: F
authors.initials: F
authors.lastname: Gomis
authors.forename: J
authors.initials: J
authors.lastname: Martínez
authors.forename: G
authors.initials: G
authors.lastname: Martín
authors.forename: J
authors.initials: J
authors.lastname: de la Rubia
authors.forename: F
authors.initials: F
authors.lastname: López
authors.forename: M A
authors.initials: MA
authors.lastname: Sanz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000401:mortality / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D014411:Neoplastic Stem Cells / Q000473:pathology; D011379:Prognosis; D012306:Risk; D016019:Survival Analysis
vernacular_title: Leucemia linfática crónica (II). Análisis de factores pronósticos y desarrollo de modelos predictivos de supervivencia. Estudio de 187 pacientes.