Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. II. Isolation and elucidation of structures.
A novel complex of antifungal and immunosuppressant compounds has been isolated from the fermentation broth and mycelia of two strains of Streptomyces diastatochromogenes. The structures of eight related components were determined employing 1D and 2D homonuclear and the heteronuclear NMR spectroscopy and mass spectrometry. These structures represent the first reported spiroketal 24-membered macrolide natural products related to the common 26-membered oligomycins.
Hochlowski
J E
JE
Pharmaceutical Products Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064.
Mullally
M M
MM
Brill
G M
GM
Whittern
D N
DN
Buko
A M
AM
Hill
P
P
McAlpine
J B
JB
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification*; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification*; D018942:Macrolides; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D018942:Macrolides