title: [Anabolic action of prolactin on phosphatidylcholine metabolism in guinea pig adrenocorticocytes].
abstract: Isolated adrenocortical cells of guinea pigs whom injected with prolactin (PRL) during 3 days incorporated [3H] choline into phosphatidylcholine more intensively than those cells of animals in control. Labelling of intracellular pools of choline and phosphorylcholine remained unchanged, though a part of radioactivity represented by the water-soluble precursors decreased due to PRL influence. The rate of disappearance of labelled phosphatidylcholine in adrenocortical cells prelabelled with [3H] choline was lower in cells obtained from PRL-treated animals. The discharge of [3N] choline accumulated during prelabeling accelerated simultaneously. Rate of the phosphorylcholine radioactivity fall remained unchanged. The obtained data showed that prolonged influence of PRL caused a shift of the phosphatidylcholine metabolism to anabolism. That effect might be a part of the mechanism of proliferative PRL action in the adrenal cortex.
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Sautin
authors.forename: N D
authors.initials: ND
authors.lastname: Tron'ko
authors.forename: E I
authors.initials: EI
authors.lastname: Kovzun
authors.forename: A S
authors.initials: AS
authors.lastname: Mikosha
mesh_terms: D000302:Adrenal Cortex / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D010713:Phosphatidylcholines / Q000378:metabolism*; D011388:Prolactin / Q000502:physiology*
chemical_list: D010713:Phosphatidylcholines; D011388:Prolactin
vernacular_title: Anabolicheskoe deĭstvie prolaktina na metabolizm fosfatidilkholina v adrenokortikotsitakh morskikh svinok.