Variant translocations of chromosome 13 in alveolar rhabdomyosarcoma.
In three cases of alveolar rhabdomyosarcoma with variant translocations, two tumors contained an identical translocation, t(1;13)(p36.1;q14); the third tumor contained a t(8;13)(p21;q14). All three patients were 2 years old, markedly younger than the median age for patients with t(2;13)-positive alveolar rhabdomyosarcoma. The alteration of genetic material on chromosome 13 may be of primary importance in the development of alveolar rhabdomyosarcoma.
Douglass
E C
EC
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101.
Rowe
S T
ST
Valentine
M
M
Parham
D M
DM
Berkow
R
R
Bowman
W P
WP
Maurer
H M
HM
D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1 / Q000648:ultrastructure*; D002882:Chromosomes, Human, Pair 13 / Q000648:ultrastructure*; D002889:Chromosomes, Human, Pair 2 / Q000648:ultrastructure; D002898:Chromosomes, Human, Pair 8 / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008297:Male; D012208:Rhabdomyosarcoma / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic