[Plasma amitriptyline level and its therapeutic effectiveness in patients with affective disorders].
57 patients treated with amitriptyline because of depressive syndrome in the course of affective disorder were studied. The drug level in plasma was measured weakly using a gas chromatograph. A non-linear correlation between the amitriptyline level in plasma and the clinical effect of the treatment was substantiated. The range of therapeutic effectiveness was determined between 68.0 and 185.0 ng/ml.
Jakitowicz
J
J
Katedry i I Kliniki Chorób Psychicznych AM w Gdańsku.
D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000639:Amitriptyline
Poziom amitryptyliny w osoczu krwi a efekt terapeutyczny leku u pacjentów z chorobami afektywnymi.