Fiber outgrowth from fetal vasopressin neurons of the suprachiasmatic nucleus, bed nucleus of the stria terminalis, and medial amygdaloid nucleus transplanted into adult Brattleboro rats.
Outgrowth of fibers from different types of vasopressin (AVP) neurons was compared in the brains of AVP-deficient Brattleboro rats. Fetal grafts of the suprachiasmatic nucleus (SCN), the bed nucleus of the stria terminalis (BST), and the medial amygdaloid nucleus (MA) were implanted into the lateral ventricle. AVP-immunoreactive fibers from all grafts entered the host tissue in the lateral septum. SCN fibers were confined to the lateral margin of the septum. In contrast, MA and BST fibers formed equally dense networks spanning the width of the lateral septum. The data suggest that these transplanted neurons show specific outgrowth, and that the phylogenetically related BST and MA neurons follow similar cues to reach their targets.
al-Shamma
H A
HA
Department of Psychology, University of Massachusetts, Amherst 01003.
De Vries
G J
GJ
D000679:Amygdala / Q000166:cytology / Q000196:embryology*; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D016332:Fetal Tissue Transplantation; D007150:Immunohistochemistry; D009412:Nerve Fibers / Q000378:metabolism / Q000502:physiology; D009474:Neurons / Q000637:transplantation*; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D013493:Suprachiasmatic Nucleus / Q000166:cytology / Q000196:embryology*; D013788:Thalamus / Q000166:cytology / Q000196:embryology*
D001127:Arginine Vasopressin