Works in progress #7. Age-dependent fibrin clot invasion by human meniscal fibrochondrocytes. A preliminary report.
This study was performed to determine whether human fibrochondrocytes possess the same biologic potential for initiating a reparative response in a meniscal defect as that found in lower vertebrates. Small, circular defects were created in meniscal fragments obtained from nine men aged 14 to 72 years. The defects were filled with purified fibrin and placed in a culture medium. By 4 weeks, there was excellent cellular penetration into all clots. This study suggests that human meniscal fibrochondrocytes are also capable of initiating a reparative response, and the rapidity of this response appears to be age dependent. The 14- and 16-year-old menisci mounted a more rapid healing response in vitro than did those obtained from skeletally mature individuals.
Vander Schilden
J L
JL
Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock.
York
J L
JL
Webber
R J
RJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D046508:Culture Techniques; D005337:Fibrin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008592:Menisci, Tibial / Q000502:physiology*; D008875:Middle Aged; D000070600:Tibial Meniscus Injuries; D014945:Wound Healing / Q000502:physiology
D005337:Fibrin