T lymphocytes bearing histamine receptors in patients with digestive neoplasm.
The inverse relationship between allergic diseases, particularly bronchial asthma, and cancer has been much debated these past years. This inverse relationship may be due to different levels of blood and tissue histamine, and its effect on lymphocytes with H2 receptors. A clinical study was performed on circulating histamine-bearing T cells and on in vivo and in vitro immune response to PPD and histamine in patients with a newly diagnosed digestive neoplasm and in patients with allergic bronchial asthma. The mean percentage of T lymphocytes with histamine receptors was significantly decreased in patients with digestive neoplasm and with allergic bronchial asthma as compared to healthy controls.
Stanciu
L
L
3rd Medical Clinic, Institute of Hygiene and Public Health, Cluj-Napoca, Romania.
Dumitrascu
D
D
Badea
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000276:immunology / Q000473:pathology; D004067:Digestive System Neoplasms / Q000276:immunology / Q000473:pathology*; D005260:Female; D006632:Histamine / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D011968:Receptors, Histamine / Q000032:analysis*; D013601:T-Lymphocytes / Q000737:chemistry*
D011968:Receptors, Histamine; D006632:Histamine