Synthesis and hypocholesterolemic activity of some N-diphenylmethylpiperazine derivatives.
The synthesis and preliminary assays as hypocholesterolemic agents of five N-diphenylmethylpiperazines are described. The evaluations were carried out in hypercholesterolemic mice and two of these compounds were more effective than bezafibrate in the test employed. The di-p-chlorosubstituted compounds showed higher activity than their corresponding dechlorinated analogs.
Alivert
A
A
C.E.T.S. Institut Químic de Sarrià, Department of Organic Chemistry, Barcelona, Spain.
Canals
F
F
Bonet
J J
JJ
Gómez-Parra
V
V
Sánchez-Alonso
F
F
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001559:Benzhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D004032:Diet; D008297:Male; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000924:Anticholesteremic Agents; D001559:Benzhydryl Compounds; D010879:Piperazines; D002784:Cholesterol