title: [The anti-inflammatory activity of structural analogs of the platelet-activating factor].
abstract: The pro- and anti-inflammatory activity of new structural analogues of the platelet-activating factor (PAF) was studied. It was found that three PAF analogues inhibit PAF-induced rat paw edema in a dose-dependent manner. The anti-inflammatory activity of one of the PAF analogues upon PAF- or carrageenan-induced inflammation was comparable or in some extent exceeded that of dexamethasone.
authors.forename: A G
authors.initials: AG
authors.lastname: Melikiants
authors.forename: V I
authors.initials: VI
authors.lastname: Kulikov
authors.forename: E E
authors.initials: EE
authors.lastname: Koloskova
authors.forename: T I
authors.initials: TI
authors.lastname: Kuznetsova
authors.forename: A A
authors.initials: AA
authors.lastname: Dergousov
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Lipatkina
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D002351:Carrageenan; D003907:Dexamethasone / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007213:Indomethacin / Q000627:therapeutic use; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010972:Platelet Activating Factor; D003907:Dexamethasone; D002351:Carrageenan; D001241:Aspirin; D007213:Indomethacin
vernacular_title: Protivovospalitel'naia aktivnost' strukturnykh analogov faktora aktivatsii trombotsitov.