Hemolysis and infection: categories and mechanisms of their interrelationship.
Different cause-and-effect relationships between hemolytic and infectious processes are categorized in a clinically useful manner as follows: infections causing hemolysis by invasion of red blood cells (RBCs), by hemolysins, or by immune mechanisms; oxidative damage to RBCs during infections; hemolysis secondary to infection-induced pathologic processes; hemolytic effects of antimicrobial therapy; and predisposition of an individual to infection caused by an underlying hemolytic disorder or therapy for that disorder. The mechanisms of these interrelationships are discussed in detail.
Berkowitz
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Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30303.
D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000209:etiology*; D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D006461:Hemolysis; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D008297:Male; D010084:Oxidation-Reduction
D000890:Anti-Infective Agents