title: [Physiopathology, etiology and medical treatment of non-calcium lithiasis].
abstract: Under the term "non-calcium nephrolithiasis", three types of renal stone formation are considered. (1) Infected nephrolithiasis, which is due to bacteriological ureolysis. Its treatment includes lowering of oversaturation by antibiotics, urease inhibition and/or acidification of the urine; lowering of crystallization by eradicating concomitant infections caused by non-ureolytic organisms; prevention of crystal adherence by exogenous glycosaminoglycans, and prevention of bacterial adherence by glycolipids. (2) Uric acid lithiasis is defined on physico-chemical and physiopathological grounds. Medical treatment consists of increasing water intake, reducing puric acid intake, alkalinizing the urine inhibiting xanthine-oxidase. (3) Cystinuria is described as a nephrolithogenic proximal tubulopathy. Medical treatment includes reduction of urinary cystine concentration by a strong increase of water intake; reduction of urinary cystine excretion by diet and increase of cystine solubility by urinary alkalinization or administration of some thiol compounds.
authors.affiliation: Policlinique médicale universitaire, hôpital de l'Ile, Berne, Suisse.
authors.forename: B
authors.initials: B
authors.lastname: Hess
authors.forename: P
authors.initials: P
authors.lastname: Jaeger
mesh_terms: D003555:Cystinuria / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D014527:Uric Acid / Q000032:analysis; D014552:Urinary Tract Infections / Q000150:complications
chemical_list: D014527:Uric Acid
vernacular_title: Physiopathologie, étiologie et traitement médical des lithiases non calciques.