[The respiratory function in children with collagen disease].
Respiratory function tests were performed on 60 children with collagen disease. Twenty-seven cases (45%) showed abnormalities in the respiratory function. These abnormalities were restrictive in 14 cases (52%), obstructive in 6 cases (22%), and mixed type in 7 cases (26%). Eight out of 14 SLE patients (57%) showed abnormalities of various types. Abnormalities were seen in 9 out of 25 JRA patients (36%) including 6 cases (67%) with restrictive type changes. Four out of 6 MCTD (67%) and 3 out of 9 DM (33%) patient showed functional abnormalities. Most of patients with these two types of collagen disease showed restrictive changes. Investigations performed by a research group of the Ministry of Health and Welfare showed the incidence of restrictive type changes (% VC less than 80) in adult patients of collagen disease to be in the following descending order: PM/DM greater than PSS greater than MCTD greater than SLE. Though small in number, our investigation revealed that a considerable proportion of MCTD and SLE patients showed restrictive changes in respiratory function. In evaluating the clinical course of the disease, it was thus considered to be important to follow up the progress of respiratory functions in children with collagen disease.
Wada
N
N
Department of Pediatrics, The Jikei University School of Medicine, Tokyo.
Fukunaga
K
K
Obata
T
T
Saito
Y
Y
Tamaki
H
H
Kobayashi
S
S
Kubo
M
M
Seki
T
T
Oishi
T
T
Joh
K
K
D000293:Adolescent; D000328:Adult; D002648:Child; D003095:Collagen Diseases / Q000503:physiopathology*; D005541:Forced Expiratory Volume; D006801:Humans; D012119:Respiration; D012129:Respiratory Function Tests; D014797:Vital Capacity