title: Epidermal growth factor in human tear fluid: a minireview.
abstract: This minireview deals with the presence of epidermal growth factor (EGF) in human tear fluid. It explains the occurrence of EGF in tear fluid, the origin of EGF and its dependency on tear fluid dynamics. The alterations in tear fluid EGF concentrations that occur during diseases of the ocular surface are described and discussed in the context of the current knowledge about the interaction between EGF and EGF receptors. The possible clinical implications of topical treatment with EGF are considered.
authors.affiliation: Department of Ophthalmology, University of Helsinki, Finland.
authors.forename: G B
authors.initials: GB
authors.lastname: van Setten
authors.forename: T
authors.initials: T
authors.lastname: Tervo
authors.forename: L
authors.initials: L
authors.lastname: Viinikka
authors.forename: J
authors.initials: J
authors.lastname: Perheentupa
authors.forename: A
authors.initials: A
authors.lastname: Tarkkanen
mesh_terms: D004815:Epidermal Growth Factor / Q000032:analysis*; D066246:ErbB Receptors / Q000032:analysis; D005128:Eye Diseases / Q000378:metabolism; D015200:Fluoroimmunoassay; D006801:Humans; D013666:Tears / Q000737:chemistry*; D014945:Wound Healing
chemical_list: D004815:Epidermal Growth Factor; D066246:ErbB Receptors