[Isolation of the antiphlogistic principle from Epilobium angustifolium].
From the leaves of Epilobium angustifolium L. (Onagraceae) an antiphlogistic principle was isolated and identified as myricetin 3-O-beta-D-glucuronide. This novel flavonoid exhibited a very strong anti-inflammatory effect on carrageenan-induced edema in the rat hind paw (more than ten times more effective than indomethacin) and an inhibitory effect on prostaglandin biosynthesis (as effective as indomethacin).
Hiermann
A
A
Institut für Pharmakognosie, Universität Graz, Austria.
Reidlinger
M
M
Juan
H
H
Sametz
W
W
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D010944:Plants; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D011453:Prostaglandins; C072578:myricetin 3-O-glucuronide
Isolierung des antiphlogistischen Wirkprinzips von Epilobium angustifolium.