title: [Gonalgia: treatment with therapeutic local anesthesia. Results of a controlled comparative study versus diclofenac].
abstract: The effectiveness and tolerance of therapeutic local anesthesia (TLA) with lidocaine was compared with those of oral diclofenac in a controlled, open, randomized study involving 76 patients with gonalgia due to gonarthrosis or patellar chondropathy. During the course of the three-week (maximum) treatment, the summed score of pain at rest, pain on movement, and restricted mobility, taken as the target parameter of effectiveness, decreased significantly more markedly (p = 0.008) under TLA, than under diclofenac. Side effects involving mainly the gastrointestinal tract occurred significantly more frequently in the diclofenac group (p = 0.012). The results of this study indicate that in the treatment of localized joint pain of degenerative genesis, TLA with lidocaine is superior to NSAID treatment in terms of effectiveness and tolerance.
authors.affiliation: Ludwig-Boltzmann-Institut für konservative Orthopädie.
authors.forename: A
authors.initials: A
authors.lastname: Berenfeld
authors.forename: W D
authors.initials: WD
authors.lastname: Bessing
authors.forename: U
authors.initials: U
authors.lastname: Bisplinghoff
authors.forename: G
authors.initials: G
authors.lastname: Bittner
authors.forename: H O
authors.initials: HO
authors.lastname: Matthiesen
authors.forename: H
authors.initials: H
authors.lastname: Tilscher
authors.forename: S
authors.initials: S
authors.lastname: Ramm
authors.forename: L
authors.initials: L
authors.lastname: Ebeling
authors.forename: H
authors.initials: H
authors.lastname: Schmitz
mesh_terms: D000328:Adult; D000772:Anesthesia, Local; D004008:Diclofenac / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000502:physiology; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D016059:Range of Motion, Articular
chemical_list: D004008:Diclofenac; D008012:Lidocaine
vernacular_title: Gonalgie: Behandlung mit der therapeutischen Lokalanästhesie. Ergebnisse einer kontrollierten Vergleichsstudie versus Diclofenac.