title: Do 15-lipoxygenases have a common biological role?
abstract: In contrast to the well-studied role of 5-lipoxygenase in the arachidonic acid cascade that occurs in inflammatory cells, the biological role of the related 15-lipoxygenases in the metabolism of free polyenoic fatty acids is far from clear. However, the activity of 15-lipoxygenases with more complex substrates may play a crucial role in the differentiation and maturation of certain cell types and in the oxidative modification of lipoproteins in the early stages of atherosclerosis.
authors.affiliation: Institute of Biochemistry, Medical School (Charité), Humboldt-University, Berlin, FRG.
authors.forename: T
authors.initials: T
authors.lastname: Schewe
authors.forename: H
authors.initials: H
authors.lastname: Kühn
mesh_terms: D000818:Animals; D001093:Arachidonate 15-Lipoxygenase / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008928:Mitochondria / Q000201:enzymology; D012156:Reticulocytes / Q000201:enzymology
chemical_list: D005227:Fatty Acids; D001093:Arachidonate 15-Lipoxygenase