[Does parenteral linoleic acid modify tumor growth? Studies with the Yoshida sarcoma model].
In an experimental study with sprague-dawley-rats we tested the effect of parenteral substituted LCT-fats on tumor growth of the Yoshida sarcoma in its ascites form. Therefore we tested 4 groups with 10 tumor-bearing and 10 non-tumor-bearing rats. We added group 1-3 LCT-fats in different doses. Group 4 was fed enterally. We found that tumor-bearing rats had a higher nitrogen retention than non-tumor-bearing rats. Non-tumor-bearing rats showed a higher nitrogen concentration in the muscles. The portion of nitrogen increased with increasing portion of fat. The content of nitrogen in the ascites, the quantity and the number of tumor cells was reversed in proportion to the portion of fat. For the host we showed that he cannot make use of the energy directly. The tumor does not grow in proportion to the available energy but has to support itself from the catabolism of the host.
Wolters
U
U
Chirurgische Universitätsklinik, Köln, BRD.
Brenner
U
U
Müller
J M
JM
Wolf
K
K
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D004734:Energy Metabolism / Q000187:drug effects; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D008041:Linoleic Acids / Q000008:administration & dosage*; D008297:Male; D009368:Neoplasm Transplantation; D009584:Nitrogen / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D051381:Rats; D011919:Rats, Inbred Strains; D012517:Sarcoma, Yoshida / Q000473:pathology*; D013024:Soybean Oil / Q000008:administration & dosage*; D014280:Triglycerides / Q000008:administration & dosage; D014882:Water-Electrolyte Balance / Q000187:drug effects
D005217:Fat Emulsions, Intravenous; D008041:Linoleic Acids; D014280:Triglycerides; D013024:Soybean Oil; D009584:Nitrogen
Beeinflusst parenterale Linolsäurezufuhr das Tumorwachstum? Untersuchungen am Beispiel des Yoshida-Sarkoms.