Comparison of the effectiveness of dithiocarbamates on the excretion and distribution of cadmium in mice.
Sodium N-benzyl-D-glucamine dithiocarbamate (BGD), sodium N-p-hydroxymethylbenzyl-D-glucamine dithiocarbamate (HBGD), and sodium N-p-methoxybenzyl-D-glucamine dithiocarbamate (MeOBGD) were evaluated for their efficacy in the distribution and excretion of cadmium in mice exposed to cadmium. Mice were injected i.p. with 109CdCl2 (1 mg Cd/kg and 74 kBq of 109Cd/mouse) and 30 min or 24 h later, they were injected i.p. with chelating agents (5% of an LD50). The results of this study indicated that the injection of HBGD to mice pretreated with cadmium can remove cadmium from the body without redistribution of cadmium to the brain, testes, and heart more effectively than that of BGD or MeOBGD.
Shimada
H
H
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Funakoshi
T
T
Kiyozumi
M
M
Kojima
S
S
D000818:Animals; D001646:Bile / Q000378:metabolism; D001923:Brain Chemistry; D002104:Cadmium / Q000493:pharmacokinetics* / Q000652:urine; D002614:Chelating Agents / Q000032:analysis / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000494:pharmacology; D013859:Thiocarbamates / Q000494:pharmacology*; D014018:Tissue Distribution
D002614:Chelating Agents; D013859:Thiocarbamates; D002104:Cadmium; C060427:N-(4-methoxybenzyl)glucamine dithiocarbamate; C068198:N-4-hydroxymethylbenzylglucamine dithiocarbamate; D013012:Sorbitol; C048763:N-benzylglucamine dithiocarbamate