[Effects of panaxadiol and panaxatriol saponins on action potentials of normal and xanthine-xanthine oxidase damaged cultured myocardial cells].
Wistar rat myocardial cells were cultured. PDS 20-80 micrograms.ml-1; PTS 1.25-20 micrograms.ml-1 dose-dependently decreased their action potential parameters, indicating the possibility of being concerned in the blockage of Ca channel. After the free radical damage was induced by xanthine 0.42 mmol.L-1--xanthine oxidase 5.3 nmol.L-1 (X-XO). All the action potential parameters of the cardiac cells decreased without exception. Both PDA and PTS antagonized the electrical appearance of membrane damage induced by X-XO, suggesting that both PDS and PTS protect the myocardial cells from oxidative damage.
Zhong
G G
GG
Department of Physiology, Norman Bethune University of Medical Sciences, Changchun, China.
Jiang
Y
Y
Wang
X Q
XQ
Yue
G
G
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002478:Cells, Cultured; D036145:Ginsenosides; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D009206:Myocardium / Q000166:cytology; D005894:Panax; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins / Q000494:pharmacology*; D014315:Triterpenes / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology
D036145:Ginsenosides; D012503:Saponins; D014315:Triterpenes; D014970:Xanthines; C048026:ginsenoside Rb2; C004564:panaxadiol; C004563:panaxatriol; D014969:Xanthine Oxidase