Effects of upper airway pressure on abdominal muscle activity in conscious dogs.
We have examined arousal and abdominal muscle electromyogram (EMGabd) responses to upper airway pressure stimuli during physiological sleep in four dogs with permanent side-hole tracheal stomata. The dogs were trained to sleep with a tightly fitting snout mask, hermetically sealed in place, while breathing through a cuffed endotracheal tube inserted through the tracheostomy. Sleep stage was determined by behavioral and electroencephalographic criteria. EMGabd activity was measured using bipolar fine-wire electrodes inserted into the abdominal muscle layers. Static increases or decreases in upper airway pressure (+/- 6 cmH2O), when applied at the snout mask or larynx (upper trachea), caused an immediate decrease in EMGabd on the first two to three breaths; EMGabd usually returned to control levels within the 1-min test interval. In contrast, oscillatory pressure waves at 30 Hz and +/- 3 cmH2O amplitude (or -2 to -8 cmH2O amplitude) produced an immediate and sustained reduction in IMGabd in all sleep states. Inhibition of EMGabd could be maintained over many minutes when the oscillatory pressure stimulus was pulsed by using a cycle of 0.5 s on and 0.5 s off. Oscillatory upper airway pressures were also found to be powerful arousal-promoting stimuli, producing arousal in 94% of tests in drowsiness and 66% of tests in slowwave sleep. The results demonstrate the presence of breath-by-breath upper airway control of abdominal muscle activity.
Plowman
L
L
David Read Laboratory, Department of Medicine, University of Sydney, New South Wales, Australia.
Lauff
D C
DC
McNamara
F
F
Berthon-Jones
M
M
Sullivan
C E
CE
D000005:Abdomen; D000818:Animals; D001143:Arousal / Q000502:physiology; D004285:Dogs; D004576:Electromyography; D009132:Muscles / Q000502:physiology*; D011175:Positive-Pressure Respiration; D011312:Pressure; D015656:Respiratory Mechanics / Q000502:physiology*; D012890:Sleep / Q000502:physiology; D014732:Vibration