On the detection of a blood-joint barrier for radiosulfate and [3H]glucosamine in single joints of aging rats.
A blood-joint barrier effect has been detected for two precursors of glycosaminoglycan biosynthesis (35SO4 and [3H]glucosamine) in single joints of adult Wistar rats by calculating the ratio between their blood plasma levels in the equilibrium range and their incorporation rates into joint tissues of knee joints (tibia and femur parts, patella) or femur and humerus heads. The barrier effect appears to be joint specific in the adult rat, because it was not found in joints of one month old rats and in tendon tissue. In 17 months old rats the barrier effect increased indicating a diminished supply of the joints with both precursors. Incorporation rates into the joint tissues, however, were higher than into the isolated glycosaminoglycans of aged rats indicating the barrier effect to be not the only cause for a diminished glycosaminoglycan biosynthesis in joint cartilage of aging rats.
Kleine
T O
TO
Med. Zentrum für Nervenheilkunde, Funktionsbereich Neurochemie, Universität Marburg.
Baumann
H J
HJ
D000375:Aging / Q000502:physiology*; D000818:Animals; D001769:Blood; D005944:Glucosamine / Q000378:metabolism*; D007596:Joints / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013461:Sulfur Oxides / Q000378:metabolism*; D013462:Sulfur Radioisotopes; D014316:Tritium
D013461:Sulfur Oxides; D013462:Sulfur Radioisotopes; D014316:Tritium; D005944:Glucosamine