title: Oesophageal involvement in rheumatoid arthritis patients: a study with oesophageal radionuclide transit using 81Krm.
abstract: Rheumatoid arthritis (RA) is an inflammatory disease affecting mainly the joints. In addition, signs of systemic disease are likely to be present although they are not always clinically evident. Oesophageal motility dysfunction, present in 75% of progressive systemic sclerosis patients, was also reported in various other connective tissue diseases. The present study involved 32 rheumatic patients devoid of any gastrointestinal complaints or diseases: 16 RA, nine Raynaud's syndrome and seven mild osteoarthritis as controls. Oesophageal transit was assessed by using 81Krm radionuclide scan, a sensitive and non-invasive technique. Diffusing lung capacity for carbon monoxide (DLCO) was performed as evidence of subclinical systemic involvement. Abnormal oesophageal transit was observed in 5/16 RA (31%). Two of them were subsequently discarded due to the presence of asymptomatic goiter and asymptomatic gastrointestinal reflux leaving 3/14 RA for analysis. They all had extra-articular features (EAF) (pericarditis, nodules) and two of them had diminished DLCO. Two with Raynaud's syndrome had abnormal oesophageal transit but none of the controls had abnormal oesophageal transit. Upper gastrointestinal dysfunction after exclusion of symptomatic patients appears thus to be not very frequent in RA, even when a sensitive technique is used. Radionuclide transit scanning of the oesophagus is not a more useful method than others in detecting early EAF in RA.
authors.affiliation: Department of Rheumatology and Physical Medicine, Saint-Pierre Hospital, Free University of Brussels, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Peretz
authors.forename: G
authors.initials: G
authors.lastname: Muller
authors.forename: J P
authors.initials: JP
authors.lastname: Praet
authors.forename: H
authors.initials: H
authors.lastname: Ham
authors.forename: J P
authors.initials: JP
authors.lastname: Famaey
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000000981:diagnostic imaging; D015154:Esophageal Motility Disorders / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D007727:Krypton Radioisotopes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D011928:Raynaud Disease / Q000150:complications* / Q000000981:diagnostic imaging
chemical_list: D007727:Krypton Radioisotopes