title: In vitro activity and cross resistance studies with cefpodoxime.
abstract: On the basis of MIC determinations and appropriate MIC breakpoints, 370 pathogens showed complete cross resistance between cefpodoxime and cefuroxime axetil, cefotiam hexetil, cefixime and cefotaxime in 69.7%, 80.3%, 92.2% and 87% of the strains, respectively. Cefpodoxime was superior to cefuroxime axetil in 28.7%, to cefotiam hexetil in 17.6%, to cefixime in 7% of strains and to cefotaxime not at all. On the other hand, we found cefpodoxime to be inferior to the cephalosporins mentioned in 1.6%, 2.1%, 0.8% and 13%, respectively.
authors.affiliation: Institute for Medical Microbiology and Clin. Chemistry (Laboratory Dr. Gaertner), Weingarten.
authors.forename: H
authors.initials: H
authors.lastname: Grimm
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000494:pharmacology; D015310:Cefotiam / Q000494:pharmacology; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests; D000097623:Cefpodoxime
chemical_list: D000892:Anti-Infective Agents, Urinary; D020682:Cefixime; D002439:Cefotaxime; D015310:Cefotiam; D015296:Ceftizoxime; D002444:Cefuroxime; D002511:Cephalosporins; D000097623:Cefpodoxime