Different stressors and blood lipid peroxidation.
Elevation of lipid peroxidation (LOX) was observed in rabbits and mice after the intravenous administration of 0.2 micrograms.kg-1 of lipopolysaccharide (LPS) and 100 micrograms.kg-1 of peptidoglycan (MP). The peak was reached sooner after peptidoglycan, and 2-4 h after LPS administration. The trends of lipid peroxidation were the same in both species. 8-10 h later original LOX blood levels were reached. Mild horizontal vibration (1 h) induced in both species a significant lowering of LOX. This appeared already immediately after the vibration. Original values were gained again after 8-10 h. The difference between the internal stressors, LPS and MP, and the external stressor, vibration, are discussed.
Lavický
J
J
Medical Faculty II, Charles University, Institute of Pharmacology, Prague, Czechoslovakia.
Rasková
H
H
D000818:Animals; D002682:Chinchilla; D015227:Lipid Peroxidation / Q000502:physiology*; D008054:Lipid Peroxides / Q000097:blood; D008055:Lipids / Q000097:blood*; D008070:Lipopolysaccharides; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D008808:Mice, Inbred CBA; D010457:Peptidoglycan; D011817:Rabbits; D013315:Stress, Psychological / Q000097:blood / Q000378:metabolism*; D014732:Vibration / Q000009:adverse effects
D008054:Lipid Peroxides; D008055:Lipids; D008070:Lipopolysaccharides; D010457:Peptidoglycan; D008315:Malondialdehyde