Diazepam-induced feeding in captive gray wolves (Canis lupus).
Diazepam doses of 0.2, 0.4, and 0.8 mg/kg induced feeding in sated gray wolves in a dose-dependent manner (p less than 0.001). Neither 0.8 mg/kg of the benzodiazepine antagonist, beta-CCP (p = 0.36), nor 0.8 mg/kg of the benzodiazepine inverse agonist, beta-CCE (p = 0.85), decreased the diazepam-induced hyperphagia. Five of 6 naive wolves (p = 0.003) ate dry dog food within 15.4 +/- 1.9 min of being given 0.4 mg/kg diazepam and freely chose dog food after the single diazepam administration.
Kreeger
T J
TJ
Department of Ecology, Evolution, and Behavior, University of Minnesota, Minneapolis 55455.
Levine
A S
AS
Seal
U S
US
Callahan
M
M
Beckel
M
M
D000818:Animals; D002243:Carbolines / Q000494:pharmacology; D002335:Carnivora / Q000523:psychology*; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D008297:Male; D012527:Satiation / Q000502:physiology
D002243:Carbolines; C024915:beta-carboline-3-carboxylic acid ethyl ester; C028585:propyl beta-carboline-3-carboxylate; D003975:Diazepam