title: History of the development of pertussis vaccine.
abstract: Bordetella pertussis and the disease whooping cough have mysterious unique features among bacterial infectious diseases. Numerous studies gradually provided information that permitted the development of a pertussis vaccine and the assessment of its potency relative to human efficacy. The advances in the understanding of B. pertussis, its pathogenicity and immunity that led to the development of a pertussis vaccine are presented.
authors.affiliation: Center for Biologics Evaluation and Research, USA Food and Drug Administration, Bethesda, MD 20892.
authors.forename: M
authors.initials: M
authors.lastname: Pittman
mesh_terms: D000818:Animals; D001886:Bordetella pertussis / Q000302:isolation & purification; D049673:History, 20th Century; D006801:Humans; D010567:Pertussis Vaccine / Q000266:history* / Q000302:isolation & purification / Q000592:standards; D014917:Whooping Cough / Q000266:history / Q000517:prevention & control
chemical_list: D010567:Pertussis Vaccine