Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. I. Taxonomy of the producing organisms, fermentation and antimicrobial activity.
The dunaimycins are a new complex of spiroketal 24-membered macrolides discovered in the fermentation broth of two actinomycetes. Based on taxonomic studies these two cultures, which were isolated from soil, were identified as Streptomyces diastatochromogenes strains AB 1691Q-321 and AB 1711J-452. The dunaimycins possess both immunosuppressive and antimicrobial activity.
Karwowski
J P
JP
Pharmaceutical Products Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064.
Jackson
M
M
Maus
M L
ML
Kohl
W L
WL
Humphrey
P E
PE
Tillis
P M
PM
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D007166:Immunosuppressive Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D018942:Macrolides