title: Pharmacokinetics of alpha-dihydroergokryptine in monkeys after oral administration.
abstract: The pharmacokinetic profile of a single dose (6 mg/kg) of alpha-dihydroergokryptine (alpha-DHEK) was established after oral administration in monkeys using a radio-immunoassay technique for non-metabolized drug. alpha-DHEK showed a plasma profile according to an open three-compartment pharmacokinetic model with a long half-life (mean = 5.787 h). The disposition of alpha-DHEK involves a fast absorption, a slow distribution phase and a slow elimination phase. alpha-DHEK showed an high total clearance and distribution volume; the drug is largely metabolized, as concluded from the very low urinary excretion.
authors.affiliation: Service of Pharmacology and Immunology, DRIPP, Gif-sur-Yvette, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Grognet
authors.forename: M
authors.initials: M
authors.lastname: Istin
authors.forename: A
authors.initials: A
authors.lastname: Zanotti
authors.forename: F
authors.initials: F
authors.lastname: Mailland
authors.forename: G
authors.initials: G
authors.lastname: Coppi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004088:Dihydroergotoxine / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D008252:Macaca fascicularis; D008297:Male
chemical_list: D004088:Dihydroergotoxine