title: [Studies on the mutagenicity of vesnarinone].
abstract: The mutagenicity of domestic Vesnarinone (OPC-8212) was studied by Ames test, micronucleus test of NIH mouse bone marrow and chromosome aberration assay in CHL cells. Negative results were obtained, which suggested that OPC-8212 did not induce prokaryotic cell gene mutation or chromosome damage both in vitro and in vivo.
authors.affiliation: Department of Biology and Cell Biology.
authors.forename: H
authors.initials: H
authors.lastname: Hu
authors.forename: Y
authors.initials: Y
authors.lastname: Xing
authors.forename: D
authors.initials: D
authors.lastname: Tao
authors.forename: X
authors.initials: X
authors.lastname: Zheng
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D011719:Pyrazines; D011804:Quinolines / Q000633:toxicity*
chemical_list: D011719:Pyrazines; D011804:Quinolines; C041667:vesnarinone