title: [New concepts of the course of cholesteatoma from the immunohistological study of 96 samples].
abstract: The immunohistological characteristics of retraction pockets, cholesteatoma matrix and granulomatous tissue have been compared. Langerhans cells, epidemic folds and sub-epithelial tissue were labelled with specific markers (HLA II, adhesion receptors, KI 67). The junction between epidermis and sub-epithelial tissue of middle ear mucosa appeared as the most inflammatory area, displaying characteristics of delayed type hypersensitivity phenomenon. CD1+ Langerhans cells appear to express class II molecules only in the vicinity of polymorphonuclear infiltrates. Epidemic proliferation seems to able place mainly in the deepest recesses of the epidermis.
authors.affiliation: Clinique ORL, CHRU de Nancy-Brabois, Vandoeuvre-les-nancy.
authors.forename: D
authors.initials: D
authors.lastname: Mayot
authors.forename: M C
authors.initials: MC
authors.lastname: Bene
authors.forename: C
authors.initials: C
authors.lastname: Perrin
authors.forename: G C
authors.initials: GC
authors.lastname: Faure
authors.forename: M
authors.initials: M
authors.lastname: Wayoff
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002781:Cholesteatoma / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D002908:Chronic Disease; D004427:Ear Diseases / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D004432:Ear, Middle; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D008875:Middle Aged; D013997:Time Factors
vernacular_title: Nouvelles conceptions de l'évolution du cholestéatome à partir de l'étude immuno-histologique de 96 prélèvements.