Radioprotection by MPG of mice ovaries exposed to sublethal gamma radiation doses at different postnatal ages.
Female Swiss albino mice were exposed at 1, 3 or 6 weeks of age respectively to sublethal doses (0.6, 1.2 and 2.4 Gy) of gamma radiation in the presence or absence of 2-mercaptopropionylglycine (MPG). Ovaries were histologically examined at different intervals after irradiation and the follicles were counted. Most follicular depletion had occurred already at postirradiation day 1 and the depletion then gradually continued. At day 35 after irradiation a few follicles could still be found in mice exposed at 1 week of age while all follicles were eliminated in mice exposed at 3 and 6 weeks of age. In MPG-treated animals the depletion of follicles was significantly less pronounced and obviously MPG to some degree protected the ovaries from radiation damage.
Mathur
S
S
Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India.
Nandchahal
K
K
Bhartiya
H C
HC
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D004307:Dose-Response Relationship, Radiation; D005260:Female; D051379:Mice; D006080:Ovarian Follicle / Q000187:drug effects / Q000528:radiation effects; D010053:Ovary / Q000187:drug effects* / Q000528:radiation effects*; D011829:Radiation Dosage; D008625:Tiopronin / Q000494:pharmacology*
D008625:Tiopronin