Rapid development of multiple squamous-cell carcinomas during chronic granulocytic leukemia.
We report a 65-year-old patient who presented a rapid eruption of keratoses on sun-exposed areas and an explosive transformation into several squamous-cell carcinomas, occurring during the accelerated phase of a chronic granulocytic leukemia. Clinical findings resembled those usually described in xeroderma pigmentosum. The role of immunosuppression, chemotherapy and possible genetic predisposition is discussed.
Disdier
P
P
Service de Médecine Interne du Prof. P.J. Weiller, Clinique Médicale B, Hôpital de La Timone, France.
Harle
J R
JR
Grob
J J
JJ
Weiller-Merli
C
C
Magalon
G
G
Weiller
P J
PJ
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000276:immunology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology
D000970:Antineoplastic Agents