title: Immune responses of lambs experimentally infected with bovine respiratory syncytial virus and Pasteurella haemolytica.
abstract: The immune responses of lambs experimentally infected with bovine respiratory syncytial virus (RSV) and Pasteurella haemolytica were compared with lambs infected with bovine RSV or Pasteurella haemolytica alone. Superinfection with P. haemolytica aggravated the reduction in the number of CD5+, CD4+ and LCA p220+ (B) lymphocytes caused by bovine RSV, but it had no effect on the neutralizing antibodies against P. haemolytica cytotoxin. Serum samples obtained from lambs experimentally infected with bovine RSV and P. haemolytica had significantly lower amounts of neutralizing antibodies to bovine RSV than those obtained from lambs infected with bovine RSV alone.
authors.affiliation: University of Liverpool, Department of Veterinary Pathology, Leahurst, Neston, Wirral, U.K.
authors.forename: R
authors.initials: R
authors.lastname: Sharma
authors.forename: Z
authors.initials: Z
authors.lastname: Woldehiwet
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000914:Antibodies, Viral / Q000096:biosynthesis*; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D003603:Cytotoxins / Q000276:immunology; D008213:Lymphocyte Activation; D016978:Mannheimia haemolytica / Q000276:immunology*; D009500:Neutralization Tests; D010326:Pasteurella Infections / Q000150:complications / Q000276:immunology / Q000662:veterinary*; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D010253:Respirovirus Infections / Q000150:complications / Q000276:immunology / Q000662:veterinary*; D012756:Sheep / Q000276:immunology* / Q000382:microbiology; D012757:Sheep Diseases / Q000276:immunology* / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D003603:Cytotoxins