Anticancer effects of a Chinese herbal medicine, juzen-taiho-to, in combination with or without 5-fluorouracil derivative on DNA-synthesizing enzymes in 1,2-dimethylhydrazine induced colonic cancer in rats.
Juzen-taiho-to (JTT; [Shi-quan-da-bu-tang], a Japanese modified Chinese herbal prescription) in combination with an anticancer drug UFT (5-fluorouracil derivative) prevented the body weight loss and the induction of the colonic cancer in rats treated with a chemical carcinogen 1,2-dimethylhydrazine (DMH), and suppressed markedly the activity of thymidylate synthetase (TS) involved in the de novo pathway of pyrimidine synthesis in colonic cancer induced by DMH.
Sakamoto
S
S
Medical Research Institute, Tokyo Medical and Dental University, Japan.
Kudo
H
H
Kuwa
K
K
Suzuki
S
S
Kato
T
T
Kawasaki
T
T
Nakayama
T
T
Kasahara
N
N
Okamoto
R
R
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005472:Fluorouracil / Q000008:administration & dosage*; D009367:Neoplasm Staging; D051381:Rats; D013937:Thymidine Kinase / Q000187:drug effects; D013940:Thymidylate Synthase / Q000187:drug effects*; D015431:Weight Loss / Q000187:drug effects
D004365:Drugs, Chinese Herbal; C063587:juzentaihoto; D013940:Thymidylate Synthase; D013937:Thymidine Kinase; D005472:Fluorouracil