Preliminary study on antiradiation effect of kuei-pi-tang.
In order to evaluate the potential action of Kuei-Pi-Tang as an antiradiation agent, colony forming units of bone marrow cells in the spleen (CFUs) were used. Different sequences of X-ray irradiation with or without Kuei-Pi-Tang administration in the groups of ICR strain mice were intraperitoneally injected 10mg/20g or 20mg/20g, once a day, for consecutive seven days before or after 4Gy X-ray irradiation. After the different treatments, whole blood was collected from the tail endings to observe the fluctuation of leukocytes, erythrocytes and thrombocytes. The administration of 20mg/20g was more effective than that of 10mg/20g. Lower radiosensitivity was observed with the treatment of 20mg/20g of Kui-Pi-Tang than that of 10mg/20g. The injection of Kuei-Pi-Tang accelerated the recovery of blood cell counts of leukocytes, erythrocytes and thrombocytes in mice irradiated with 4Gy, especially for leukocytes under the treatments with 20mg/20g of Kuei-Pi-Tang administered after irradiation.
Hsu
H Y
HY
School of Technology for Medical Sciences, Kaohsiung Medical College, Taiwan.
Ho
Y H
YH
Lian
S L
SL
Lin
C C
CC
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D001856:Bone Marrow Examination; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004906:Erythrocyte Count; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010976:Platelet Count; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal