[Gallopamil and changes of adenosine diphosphate- and collagen-induced thrombocyte aggregation].
In blood samples of 12 healthy volunteers (5 female, 7 male) the influence of Gallopamil (Procorum, CAS 16662-47-8) on the adenosine-diphosphate- (ADP-) and collagen-induced platelet aggregation was studied. Measurements in platelet rich plasma after induction with 1 mumol ADP and 0.5 microgramml collagen with gallopamil were performed. After incubation mit 250 mumol gallopamil a second test was carried out. The parameters were compared with the U-test. After application of 250 mumol gallopamil a significant reduction of ADP- and collagen-induced platelet aggregation could be observed. This is a sign for a protective effect of gallopamil in atherosclerotic disorders due to its calcium-channel blocking property.
Költringer
P
P
Abteilung für Neurologie, Krankenhaus der Barmherzigen Brüder Graz-Eggenberg.
Langsteger
W
W
Lind
P
P
Pierer
G
G
Reisecker
F
F
Eber
O
O
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000328:Adult; D003094:Collagen / Q000494:pharmacology*; D005260:Female; D005711:Gallopamil / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D005711:Gallopamil; D000244:Adenosine Diphosphate; D003094:Collagen
Gallopamil und Veränderungen der Adenosin-diphosphat- und Kollagen-induzierten Thrombozyten-Aggregation.