title: The proteolytic activation of interleukin-1 beta.
abstract: Interleukin-1 beta (IL-1 beta) is released from an inactive precursor by a proteolytic cleavage. A monocytic protease has been identified that appears to be involved in the physiological activation of this cytokine. Two situations have been found in which precursor IL-1 beta exists without the monocytic processing enzyme, and in these cases other proteases, such as neutrophil elastase, cathepsin G and cathepsin L, may be involved in generating the active cytokine.
authors.affiliation: Department of Protein Chemistry, Immunex Corp., Seattle, WA 98101.
authors.forename: R
authors.initials: R
authors.lastname: Black
authors.forename: S
authors.initials: S
authors.lastname: Kronheim
authors.forename: P
authors.initials: P
authors.lastname: Sleath
authors.forename: T
authors.initials: T
authors.lastname: Greenstreet
authors.forename: G D
authors.initials: GD
authors.lastname: Virca
authors.forename: C
authors.initials: C
authors.lastname: March
authors.forename: T
authors.initials: T
authors.lastname: Kupper
mesh_terms: D002460:Cell Line; D010450:Endopeptidases / Q000502:physiology; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D009000:Monocytes / Q000201:enzymology
chemical_list: D007375:Interleukin-1; D010450:Endopeptidases