The male antifertility activity of 6-chloro-6-deoxyglucose.
6-Chloro-6-deoxy[U-14C]glucose is not metabolised by mature boar spermatozoa nor has it any specific inhibitory action on their metabolic activity in vitro. The compound is metabolised by the male rat and the identification of two urinary metabolites as alpha-chlorohydrin and 3-chlorolactate confirmed that (S)-3-chlorolactaldehyde is produced by this species in vivo. A tissue distribution study revealed that radioactivity from 6-chloro-6-deoxy[U-14C]glucose was more concentrated in rat caudal spermatozoa than in any other of the major tissues.
Jones
A R
AR
Department of Biochemistry, University of Sydney, N.S.W., Australia.
Dobbie
M S
MS
D000818:Animals; D002250:Carbon Radioisotopes; D003272:Contraceptive Agents, Male / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013094:Spermatozoa / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D013552:Swine
D002250:Carbon Radioisotopes; D003272:Contraceptive Agents, Male; C021163:6-chloro-6-deoxyglucose; D003847:Deoxyglucose