title: Effect of buflomedil, dipyridamole and indobufene on hemorrheologic and blood coagulation parameters in patients who underwent vascular surgery for severe atherosclerosis.
abstract: We studied 30 patients (age range 58 to 64 years) who underwent vascular surgery for peripheral vascular disease (24 patients) and for carotid stenosis (6 patients). At the time of the study, all subjects have been taking antiplatelet agents for at least three months. They were divided into three groups of ten patients each: the first group received buflomedil (BUF), the second dipyridamole (DIP) and the third indobufene (IND), as treatment before vascular surgery. We investigated the influence of these drugs on hemorrheologic (hematocrit, whole blood and plasma viscosity) and blood coagulation (partial thromboplastin time, prothrombin time and bleeding time) parameters in all patients. In our experience, none of the three drugs influenced any tested parameters, which were within normal limits: among them we noted only a statistically significant difference in bleeding time between patients treated with BUF and IND.
authors.affiliation: Institute of Medical Semeiotics, University of Padua, Medical School, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mares
authors.forename: F
authors.initials: F
authors.lastname: Sogaro
authors.forename: M A
authors.initials: MA
authors.lastname: Scomparin
authors.forename: G
authors.initials: G
authors.lastname: Boeri
authors.forename: G
authors.initials: G
authors.lastname: Cella
mesh_terms: D001161:Arteriosclerosis / Q000097:blood* / Q000601:surgery; D001777:Blood Coagulation / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects*; D004176:Dipyridamole / Q000494:pharmacology*; D005260:Female; D006801:Humans; D054833:Isoindoles; D008297:Male; D008875:Middle Aged; D010654:Phenylbutyrates / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D014656:Vascular Surgical Procedures
chemical_list: D054833:Isoindoles; D010654:Phenylbutyrates; D010975:Platelet Aggregation Inhibitors; D011759:Pyrrolidines; D004176:Dipyridamole; C020371:indobufen; C010651:buflomedil