Pathogenesis of suxamethonium-induced muscle damage in the biventer cervicis muscle in the chick.
Muscle damage induced by suxamethonium, and the influence of halothane on it, has been examined by measuring the efflux of creatine kinase (CK) in the biventer cervicis muscle of the chick. Whereas halothane and suxamethonium alone did not increase the enzyme efflux significantly, the combination of the two was associated with significant increase in the concentration of CK in the bathing medium by 59-157%. The increase in CK was prevented by adding chlorpromazine 100 mumol litre-1 to the medium, suggesting the involvement of phospholipases in the pathogenesis of suxamethonium-induced muscle damage.
McLoughlin
C
C
Department of Anaesthetics, Queen's University of Belfast.
Mirakhur
R K
RK
Trimble
E R
ER
Clarke
R S
RS
D000818:Animals; D002645:Chickens; D002746:Chlorpromazine / Q000494:pharmacology; D003402:Creatine Kinase / Q000378:metabolism*; D004357:Drug Synergism; D006221:Halothane / Q000037:antagonists & inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D009132:Muscles / Q000187:drug effects* / Q000201:enzymology; D013390:Succinylcholine / Q000037:antagonists & inhibitors / Q000633:toxicity*
D003402:Creatine Kinase; D013390:Succinylcholine; D002746:Chlorpromazine; D006221:Halothane