Application of the ARMA method to acoustic detection of coronary artery disease.
To further explore the application of advanced signal processing techniques to the noninvasive detection of coronary artery disease, 30 patients (10 angioplasty and 20 normal or abnormal) were tested using autoregressive moving average (ARMA) modelling of the diastolic heart sound data. It is during diastole that coronary blood flow is maximum and sounds associated with turbulent blood flow through partially occluded coronary arteries would be loudest. Model parameters (the power spectral density (PSD) functions and the poles of the ARMA method) were used to separate the normal patients from the abnormal patients in the normal/abnormal study, or to decide whether the recordings were made before or after angioplasty in the angioplasty study. The decisions were made 'blind', without knowledge of the actual disease states of the patients for the normal/abnormal study and without prior knowledge of whether a given recording was made before or after angioplasty for the angioplasty study. Results from the angioplasty and the normal/abnormal studies showed that pre- and post-angioplasty records were correctly distinguished in 8 out of 10 cases, and normal and abnormal records were correctly distinguished in 17 of 20 cases. These results also confirmed that high frequency energy above 400 Hz is probably associated with coronary stenosis.
Akay
M
M
Biomedical Engineering Department, Rutgers University, NJ 08855.
Welkowitz
W
W
Semmlow
J L
JL
Kostis
J
J
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001157:Arterial Occlusive Diseases / Q000175:diagnosis*; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006347:Heart Sounds / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D011184:Postoperative Period