[The dynamics of prednisolone and dexamethasone distribution and metabolism in the body of white rats].
The processes of elimination and distribution of the synthetic steroidal drugs prednisolone and dexamethasone in the internal organs of Wistar rats were studied by the method of radioisotopes and high performance liquid chromatography. It was shown that the main route of excretion is the elimination with the urine. Prednisolone does not undergo conjugation and dexamethasone is glucuronidated by approximately 20%. The conclusion is made about the dependence of the main pharmacokinetic parameters on the concrete route of metabolism of each drug.
Krylov
Iu F
IuF
Krynetskiĭ
E Iu
EIu
Maruzhenkov
D S
DS
Prokhorov
B S
BS
D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003907:Dexamethasone / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D011239:Prednisolone / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors; D014018:Tissue Distribution; D014316:Tritium
D014316:Tritium; D003907:Dexamethasone; D011239:Prednisolone
Dinamika raspredeleniia i metabolizm prednizolona i deksametazona v organizme belykh krys.