title: Effect of storage on the plasma concentration of chlorpromazine and six of its metabolites.
abstract: The concentrations of chlorpromazine (CPZ) and six of its metabolites in patient plasma samples that had been stored for 24 h at -20 degrees C, for 1 week at -20 degrees C, and for 4 weeks at -70 degrees C were compared. The concentrations of CPZ and six of its metabolites in human plasma spiked with known concentrations and stored at -70 degrees C for either 3 or 12 months were also compared. No significant difference was seen in the concentrations after storage under nitrogen and analysis by a high-performance liquid chromatography technique.
authors.affiliation: Pharmacology Department, University of Durban-Westville, Republic of South Africa.
authors.forename: M
authors.initials: M
authors.lastname: Chetty
authors.forename: R
authors.initials: R
authors.lastname: Miller
mesh_terms: D002746:Chlorpromazine / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004356:Drug Storage; D006801:Humans; D012559:Schizophrenia / Q000378:metabolism
chemical_list: C046144:chlorpromazine N-oxide; C022891:didemethylchlorpromazine sulfoxide; C029699:norchlorpromazine; C007994:7-hydroxychlorpromazine; D002746:Chlorpromazine