Effects of glucagon on serum calcium, magnesium and strontium levels in rats.
The pharmacological effects of glucagon (0.05 mg/kg b.wt. day) on serum calcium, magnesium and strontium levels were analyzed in order to clarify the response of divalent cations to glucagon administration and its possible relation with calcitonin release stimulation. The results show significant decreases in serum calcium and strontium levels 2 h after glucagon administration, and in daily administration the effect peaks on the 3rd day and returns to baseline values by the 9th day. In contrast, the serum magnesium increases significantly by the 3rd day of daily glucagon administration and continues to increase until the 9th day. Calcitonin administration (90 mU Medical Research Council unit)/100 g b.wt.) significantly reduces the serum calcium, strontium and magnesium levels up to the 3rd day of treatment, just when the glucagon effect is highest. Other additional mechanisms may be involved besides the calcitonin release stimulation, in the response induced in divalent cations--particularly magnesium--by the exogenous administration of glucagon.
Escanero
J F
JF
Departamento de Fisiología, Facultad de Medicina de Zaragoza, Universidad de Zaragoza, España.
Córdova
A
A
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology; D002118:Calcium / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D008274:Magnesium / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013324:Strontium / Q000097:blood*
D002116:Calcitonin; D005934:Glucagon; D008274:Magnesium; D002118:Calcium; D013324:Strontium