title: Effect of size fractionation on the distribution of an albumin colloid in the reticuloendothelial system of the mouse.
abstract: To study if by varying the particle size of a 99mTc albumin colloid preparation its relative bone marrow accumulation could be increased, it was separated by gel filtration and different fractions were injected into mice. Particles around and smaller than the peak size of the colloid, 31 nm, exhibited a higher bone marrow/liver-spleen uptake ratio than larger particles but the uptake ratio was similar to that of the unseparated colloid. An antimony sulphide colloid showed a similar particle size distribution, but the corresponding uptake ratio was half of the albumin colloid. This indicates that characteristics other than size determine the distribution of a colloid in the reticuloendothelial system.
authors.affiliation: Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Kalin
authors.forename: P
authors.initials: P
authors.lastname: Sellin
authors.forename: S
authors.initials: S
authors.lastname: Von Krusenstierna
authors.forename: P O
authors.initials: PO
authors.lastname: Schnell
authors.forename: H
authors.initials: H
authors.lastname: Jacobsson
mesh_terms: D000818:Animals; D002850:Chromatography, Gel; D003102:Colloids; D008297:Male; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000000981:diagnostic imaging*; D010316:Particle Size; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D014018:Tissue Distribution
chemical_list: D003102:Colloids; D013668:Technetium Tc 99m Aggregated Albumin