title: Routine examination by ultrasound for the detection of fetal malformations in a low risk population.
abstract: A low risk population was offered screening for malformations in the second and third trimesters of pregnancy. Of 16,763 scans of pregnancies in the second trimester, 61 malformations were identified (0.36%). In the third trimester, scanning of 10,752 pregnancies revealed 24 malformations (0.22%): in all, in a low risk population 0.58% major malformations were found. The sensitivity for noncardiac malformations of the second trimester scanning was 54.3 with a specificity of 99.9%. The malformations overlooked was a more benign spectrum than the cases diagnosed. The sensitivity for cardiac malformations was less than 20%.
authors.affiliation: Department of Obstetrics and Gynecology, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: V
authors.initials: V
authors.lastname: Brocks
authors.forename: J
authors.initials: J
authors.lastname: Bang
mesh_terms: D000013:Congenital Abnormalities / Q000000981:diagnostic imaging* / Q000196:embryology; D003955:Diagnostic Tests, Routine; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D005865:Gestational Age; D006801:Humans; D008403:Mass Screening; D011237:Predictive Value of Tests; D011247:Pregnancy; D016216:Ultrasonography, Prenatal