[Monitoring the treatment of precocious puberty with a GnRH-analog (buserelin): comparison of the GnRH-test with nocturnal pulsatility of LH, testosterone and 17-beta-estradiol].
We studied in 10 children (3 boys and 7 girls), affected by precocious puberty and treated for a period of more than 6 months with the GnRH-analog Buserelin, the efficacy of the GnRH test versus the study of spontaneous nocturnal secretion of LH, testosterone and 17 beta-estradiol as a means of testing the gonadotropin suppression. All the subjects have shown a total suppression of LH during the GnRH test as well as a nocturnal profile of LH, testosterone and 17 beta-estradiol of a prepubertal pattern. Clinically all the patients were treated successfully. Considering the effectiveness of both investigations, we conclude that the GnRH test combined with clinical observation is a single and valid means of testing the pharmacological treatment for precocious puberty.
Radetti
G
G
Reparto di Pediatria, Ospedale Regionale di Bolzano, Italia.
Pasquino
B
B
Castellan
C
C
Gentili
L
L
Mengarda
G
G
D002064:Buserelin / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D016903:Drug Monitoring / Q000379:methods*; D004958:Estradiol / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011629:Puberty, Precocious / Q000097:blood / Q000188:drug therapy*; D013739:Testosterone / Q000097:blood
D012739:Gonadal Steroid Hormones; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D002064:Buserelin
Monitoraggio della terapia per la pubertà precoce con un analogo del GnRH (Buserelin): confronto fra il GnRH-test e la pulsatilità notturna di LH, testosterone e 17 beta-estradiolo.