title: Sedation by propofol in tetanus--is it a muscular relaxant?
abstract: We investigated the muscular relaxant properties of propofol in a 54 year-old-man with severe tetanus. Four consecutive boluses of propofol 50 mg i.v. were administered. Mean muscular activity recorded on an electromyography (EMG) decreased from 100 to 10-25 mV within 15 s after each bolus. EMG values were restored to prior levels 10 min after the last bolus. Maximum decrease of muscular activity was observed with propofol blood level between 2.90-3.20 micrograms.ml-1. Neuromuscular function recorded by means of evoked electromyography was not affected by propofol administration.
authors.affiliation: Surgical Intensive Care Unit, University Hospital of Geneva, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Borgeat
authors.forename: C
authors.initials: C
authors.lastname: Dessibourg
authors.forename: M
authors.initials: M
authors.lastname: Rochani
authors.forename: P M
authors.initials: PM
authors.lastname: Suter
mesh_terms: D004569:Electroencephalography / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D013742:Tetanus / Q000150:complications*; D014313:Trismus / Q000097:blood / Q000188:drug therapy* / Q000209:etiology
chemical_list: D015742:Propofol