title: Effects of ubidecarenone in an exercise training program for patients with chronic obstructive pulmonary diseases.
abstract: A study was undertaken to determine the usefulness of ubidecarenone in pulmonary rehabilitation in exercise training programs in the management of chronic obstructive pulmonary disease (COPD). The subjects were 20 patients with COPD who had been participating in an exercise training program for at least four weeks. The patients were randomly assigned either to receive 50 mg of oral ubidecarenone daily or to enter a control group during the program. Oxygen consumption, expired volume, and heart rate were measured during exercise tests before and after training. Maximum oxygen consumption increased 13% in the ubidecarenone-treated patients and 7% in the controls, and maximum expired volume increased 10% in each group. The increases were significant in the ubidecarenone group but not in the controls. Heart rate increased 2% in both groups. It is concluded that ubidecarenone deserves further evaluation in exercise training programs for patients with COPD.
authors.affiliation: Clinica del Lavoro Foundation, Medical Center of Tradate, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Satta
authors.forename: M
authors.initials: M
authors.lastname: Grandi
authors.forename: C V
authors.initials: CV
authors.lastname: Landoni
authors.forename: G B
authors.initials: GB
authors.lastname: Migliori
authors.forename: A
authors.initials: A
authors.lastname: Spanevello
authors.forename: G
authors.initials: G
authors.lastname: Vocaturo
authors.forename: M
authors.initials: M
authors.lastname: Neri
mesh_terms: D003067:Coenzymes; D005081:Exercise Therapy; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000378:metabolism / Q000534:rehabilitation; D010101:Oxygen Consumption / Q000187:drug effects; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10