Transforming activity of ethylene dibromide in BALB/c 3T3 cells.
Ethylene dibromide was capable of inducing in vitro transformation of BALB/c 3T3 cells either in the presence or in the absence of exogenous metabolic activation (S9-mix). This transforming effect was evidenced by the induction of a higher number of transformed foci as compared to the controls performed with untreated cells or solvent vehicle-treated cells. In the absence of exogenous activation, all assayed doses (ranging from 23.4 micrograms/ml to 187.9 micrograms/ml) exerted transforming activity. Number of foci obtained in EDB-treated plates antransformation frequency of the target cells were higher than those detected in the transformation test performed in the presence of S9-mix.
Perocco
P
P
Centro Interuniversitario per la Ricerca sul Cancro, Universita' di Bologna, Italy.
Colacci
A
A
Santucci
M A
MA
Vaccari
M
M
Grilli
S
S
D016475:3T3 Cells; D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity; D001711:Biotransformation; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D015946:Ethylene Dibromide / Q000493:pharmacokinetics / Q000633:toxicity*; D008748:Methylcholanthrene / Q000633:toxicity; D051379:Mice
D015946:Ethylene Dibromide; D001564:Benzo(a)pyrene; D008748:Methylcholanthrene