[Prevalence of reactions to drugs in 251 patients with urticaria-angioedema syndrome].
We studied 251 outpatients affected by chronic and acute urticaria-angioedema syndrome, triggered or exacerbated by drugs, to evaluate the prevalence of adverse reactions to each pharmacological group. Among these patients, 134 (53.4%) presented one or more adverse reactions to a single drug: 100 (74.7%) reacted to NSAIDs, 33 (24.7%) to antibiotics and 1 to B vitamin complex. The remaining 117 patients (46.6%) presented adverse reactions to more than one drug. Considering the patients all together, 123 (49%) had adverse reactions to ASA, 116 (46.2%) to pyrazones, 65 (25.9%) to antibiotics, 26 (10.3%) to NSAIDs different from ASA and pyrazones. In our experience, according to other reports, there is a greater frequency of drug reactions to NSAIDs vs other drugs. ASA is the more frequently involved drug.
Braga
M
M
Spedali Civili di Brescia, Cattedra di Immunologia Clinica, Università degli Studi di Brescia.
Cattaneo
R
R
Soldati
F
F
Franzini
M T
MT
Tosoni
C
C
D000799:Angioedema / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D013577:Syndrome
Prevalenza di reazioni a farmaci in 251 pazienti affetti da sindrome orticaria-angioedema.