Cancer promotion in cells initiated by polycyclic aromatic hydrocarbons and other non-viral carcinogens.
Permanent membrane lesions that initiate cells to transformation by polycyclic aromatic hydrocarbons and other non-viral carcinogens are inherited by the daughter cells at mitosis. This causes elevation of intracellular pH and suggests promotion mechanisms.
Beech
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D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007424:Intracellular Fluid / Q000378:metabolism; D008938:Mitosis; D008954:Models, Biological; D011083:Polycyclic Compounds / Q000633:toxicity*
D002273:Carcinogens; D011083:Polycyclic Compounds