[Modeling the interaction of anti-cataract drugs with membranes of normal human crystalline lenses and those with cataracts].
Anti-cataract drugs ability to diffuse into the lens at different forms of cataract was studied on a model system. For this purpose the ability of these drugs to interact with monolayers of lipids from normal and cataract lenses was appreciated. It was shown that the equilibrium surface pressure developed by the drugs after their injection under the monolayer did not depend on whether normal or pathological lipids were used.
Chasovnikova
L V
LV
Formaziuk
V E
VE
Sergienko
V I
VI
Belikova
T V
TV
Vladimirov
Iu A
IuA
D000328:Adult; D000818:Animals; D002336:Carnosine / Q000494:pharmacology / Q000627:therapeutic use*; D002386:Cataract / Q000188:drug therapy* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004058:Diffusion; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007908:Lens, Crystalline / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D051379:Mice; D008854:Microscopy, Electron; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000378:metabolism
D008563:Membrane Lipids; D010713:Phosphatidylcholines; D002336:Carnosine; D002784:Cholesterol
Modelirovanie vzaimodeĭstviia antikataraktal'nykh lekarstv s membranami normal'nykh i kataraktal'nykh chelovecheskikh khrustalikov.