title: HLA-B40: a marker for susceptibility to lung disease in rheumatoid arthritis.
abstract: We have compared the frequency of HLA antigens in groups of patients with rheumatoid arthritis (RA) who had pulmonary manifestations, other extra-articular features or articular disease alone. There was a significantly increased frequency of the antigen HLA-B40 in patients with lung involvement compared to other forms of extra-articular RA (relative risk 40.54), and when compared to the total RA group (relative risk 4.94). In contrast there was little variation in the frequency of HLA-DR4, which was significantly increased in all patient groups. These data suggest that HLA-B40 is a marker of increased susceptibility to lung disease in patients with rheumatoid arthritis.
authors.affiliation: Department of Rheumatology, Charing Cross Hospital, London.
authors.forename: P J
authors.initials: PJ
authors.lastname: Charles
authors.forename: M C
authors.initials: MC
authors.lastname: Sweatman
authors.forename: J R
authors.initials: JR
authors.lastname: Markwick
authors.forename: R N
authors.initials: RN
authors.lastname: Maini
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000235:genetics / Q000276:immunology; D015415:Biomarkers; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D015235:HLA-B Antigens / Q000032:analysis*; D059947:HLA-B40 Antigen; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000235:genetics* / Q000276:immunology; D008297:Male; D012016:Reference Values
chemical_list: D015415:Biomarkers; D015235:HLA-B Antigens; D059947:HLA-B40 Antigen