[The effect of dipyridamole on hippurate excretion in healthy volunteers and in patients with renal insufficiency].
Organic anions retained in patients with renal failure participate in a substantial way in the metabolic acidosis and thus also the catabolism in renal failure. The basic disorder is the reduced capacity of the transport system of organic ions. Therefore drugs are sought to enhance its activity. Acute investigation of healthy volunteers revealed that 150 mg dipyridamol increased the urinary hippurate excretion, while the serum hippurate concentration declined. In patients with renal failure there is the same tendency, though less marked, and due to the variability of functions of individual patients this trend is insignificant. It is assumed that this hitherto not described action of dipyridamol may be of therapeutic importance when administered to patients with impaired renal function.
Gajdos
M
M
Centrum klinickej farmakológie Ustavu preventívnej a klinickej medicíny, Bratislava.
Spustová
V
V
Stefíková
K
K
Dzúrik
R
R
D004176:Dipyridamole / Q000494:pharmacology*; D006626:Hippurates / Q000652:urine*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000652:urine*
D006626:Hippurates; D004176:Dipyridamole
Vplyv dipyridamolu na vylucovanie hipurátu u zdravých dobrovol'níkov a pacientov v renálnej insuficiencii.