Effect of vanadate on renal function in rats with streptozotocin-induced diabetes.
The effects of vanadate on glycemic control (HbA1c) and renal function was assessed in streptozotocin-induced diabetic rats (STZ-D) with heminephrectomy. Vanadate-treated rats had a significantly lower HbA1c level compared with STZ-D rats without vanadate at 8 weeks after initiation of this study. In the STZ-D rats with vanadate, there were significant decreases in the urinary albumin and IgG excretion rates. The present findings suggest that glycemic control by oral administration of vanadate, which does not cause insulin release, improves diabetic renal function.
Nakazawa
A
A
First Department of Internal Medicine, Niigata University, School of Medicine, Japan.
Igarashi
K
K
Tani
N
N
Momotsu
T
T
Ito
S
S
Shibata
A
A
D000419:Albuminuria; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000032:analysis; D007074:Immunoglobulin G / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D009392:Nephrectomy; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D014638:Vanadates / Q000494:pharmacology*
D006442:Glycated Hemoglobin; D007074:Immunoglobulin G; D014638:Vanadates