title: Excretion of indomethacin in breast milk.
abstract: 1. The excretion of indomethacin into breast milk and subsequent exposure of infants was studied in 16 women and seven of their infants. The median milk:plasma ratio in seven patients where there were measurable drug concentrations in both milk and plasma was 0.37. 2. Total infant dose, assuming a daily milk intake of 150 ml kg-1 and 100% absorption, ranged from 0.07% to 0.98% (median = 0.18%) of the weight adjusted maternal dose. 3. Plasma samples were obtained in seven infants. In six of these, indomethacin concentrations were below the sensitivity of the assay (less than 20 micrograms l-1), while one infant had a plasma indomethacin concentration of 47 micrograms l-1. 4. No adverse effects due to indomethacin were reported in the infants.
authors.affiliation: Department of Pharmacy, King Edward Memorial Hospital for Women, Subiaco, Western Australia.
authors.forename: T H
authors.initials: TH
authors.lastname: Lebedevs
authors.forename: R E
authors.initials: RE
authors.lastname: Wojnar-Horton
authors.forename: P
authors.initials: P
authors.lastname: Yapp
authors.forename: M J
authors.initials: MJ
authors.lastname: Roberts
authors.forename: L J
authors.initials: LJ
authors.lastname: Dusci
authors.forename: L P
authors.initials: LP
authors.lastname: Hackett
authors.forename: K F
authors.initials: KF
authors.lastname: Ilett
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D007231:Infant, Newborn; D008297:Male; D008895:Milk, Human / Q000378:metabolism*
chemical_list: D007213:Indomethacin