Development, characterization and evaluation of an auto-regulatory delivery system for insulin.
A self-regulatory delivery system for insulin was designed, based on the competitive and complementary binding behaviour of Concanavalin with glucose and glycosylated insulin. By encapsulating the Con-A bound G- insulin in a suitable polymer membrane, which was permeable to both glucose and insulin, the insulin efflux was regulated in response to glucose influx.
Vyas
S P
SP
Department of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya, Sagar, India.
Karajgi
J S
JS
Gogoi
P J
PJ
Jain
N K
NK
D000818:Animals; D001667:Binding, Competitive; D001786:Blood Glucose / Q000378:metabolism; D002214:Capsules; D002417:Cattle; D003208:Concanavalin A / Q000737:chemistry; D005947:Glucose / Q000737:chemistry / Q000378:metabolism*; D007328:Insulin / Q000737:chemistry / Q000378:metabolism*; D007332:Insulin Infusion Systems; D008297:Male; D008567:Membranes, Artificial; D008854:Microscopy, Electron; D011817:Rabbits
D001786:Blood Glucose; D002214:Capsules; D007328:Insulin; D008567:Membranes, Artificial; D003208:Concanavalin A; D005947:Glucose