[Effects of etafon on calcium ion contents in smooth muscle cells of the aorta].
Aethaphonium (dialicor) in 5-20 microM concentrations causes the dose dependent Ca decreasing in resting smooth muscle cells of rabbit aorta. In dose of 0.5-2.0 microM dialicor decreases the extent of transient in cytosolic-free calcium induced by application acetylcholine (10 microM) and high extracellular K (119 microM). This effect of dialicor is most expressed in attitude to the myocytes, containing the hyper K medium.
Sergeev
P V
PV
Dukhanin
A S
AS
Nikolaevskiĭ
V A
VA
Reznikov
K M
KM
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001011:Aorta; D002118:Calcium / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D011405:Propafenone / Q000031:analogs & derivatives* / Q000494:pharmacology; D011817:Rabbits
C001162:etafenone; D011405:Propafenone; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium
Vliianie étafona na soderzhanie ionov kal'tsiia v gladkomyshechnykh kletkakh aorty.