C-peptide/creatinine ratio in early morning urine as an indicator of residual B-cell function in insulin-dependent diabetes.
The C-peptide/creatinine (Cr) ratio in early morning urine was evaluated to assess B-cell function. The subjects were 12 boys and 36 girls with insulin-dependent diabetes mellitus (IDDM). The controls were 130 boys and 137 girls aged 4-15 years. There was a significant inverse correlation of this ratio with the duration of insulin therapy (r = -0.5807, P less than 0.01). The daily insulin dose in U/kg was significantly different among the following groups: 1.22 +/- 0.31 U/kg in group 1 with undetectable C-peptide, 0.94 +/- 0.37 in group 2 with a decreased ratio and 0.45 +/- 0.28 in group 3 with a normal ratio. HbA1 levels were 11.3 +/- 1.6% in group 1 and 9.2 +/- 1.1% in group 3. The difference was significant. The result shows that the C-peptide/Cr ratio in early morning urine is useful for assessing B-cell function in diabetic children.
Sasaki
N
N
Division of Endocrinology, Chiba Children's Hospital, Japan.
Miyamoto
S
S
Niimi
H
H
Nakajima
H
H
D000293:Adolescent; D000367:Age Factors; D002096:C-Peptide / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D003404:Creatinine / Q000652:urine*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000503:physiopathology* / Q000652:urine; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D007515:Islets of Langerhans / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D012016:Reference Values; D012737:Sex Factors; D013997:Time Factors
D002096:C-Peptide; D003404:Creatinine; D006442:Glycated Hemoglobin; D007328:Insulin