Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine.
We report the case of a patient who developed myoclonus and hyperalgesia following administration of high-dose subarachnoid morphine. This complication occurred with 40-80 mg/day continuous infusion. The pathophysiology of these side effects is discussed.
de Conno
Franco
F
Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, 20133 Milan Italy Department of Radiology, National Cancer Institute of Milan, 20133 Milan Italy Palliative Care Unit, USSL 75 / IV, 20143 Milan Italy.
Caraceni
Augusto
A
Martini
Cinzia
C
Spoldi
Elio
E
Salvetti
Monica
M
Ventafridda
Vittorio
V
D004334:Drug Administration Schedule; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced*; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D009207:Myoclonus / Q000139:chemically induced*
D009020:Morphine