[Psoriasis: physiopathology and therapeutic targets].
Psoriatic lesions are characterized by hyperproliferation of keratinocytes associated with differentiation disorders. Hyperproliferation might be due to extrakeratinocytic signals delivered by dermal fibroblasts, protease-secreting granulocytes, lymphocytes involved in local immune reaction or growth factors produced at a distance. An alternative theory puts the blame on intrinsic abnormalities of keratinocytes which would affect the transduction phenomena or the genome. The abnormal expression of certain genes coding for growth factors is in favour of that theory. Vertically transmitted retroviral agents may also be suspected. The points of impact of the major therapies (antimitotic drugs, cyclosporin, retinoids, phototherapy) are numerous, but their common end-result is to block the mitotic activity.
Guilhou
J J
JJ
Service de Dermatologie-phlébologie, hôpital Saint-Charles, Montpellier.
D002455:Cell Division; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology; D011565:Psoriasis / Q000503:physiopathology* / Q000628:therapy
Psoriasis: physiopathologie et cibles thérapeutiques.