Hydrogel grafted surfaces: protein interaction and platelet adhesion.
The blood compatibility of an artificial polymeric implant largely depends on the physicochemical nature of the polymer substrate. In the present study our aim is to develop an understanding of polymer surfaces having similar surface free energy, but different chemical characteristics. We attempted to graft hydrogels onto a silastic polyurethane (Angioflex) material and optimised the surface free energy to about 35.0 ergs/cm2. We compared the protein adsorption and platelet and lymphocyte adhesion on these surfaces. It is observed that there is a relative change in behavior because of the difference in chemical nature.
Hari
P R
PR
Biosurface Technology Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum, India.
Sharma
C P
CP
D000327:Adsorption; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002417:Cattle; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010973:Platelet Adhesiveness; D011092:Polyethylene Glycols; D019736:Prostheses and Implants
D001798:Blood Proteins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols