title: Effect of perfluorodecalin on activities of hepatic phase II xenobiotic biotransformation enzymes.
abstract: The activity of the hepatic phase II enzymes of xenobiotic biotransformation after intravenous administration of perfluorodecalin emulsion to rats was measured. Perfluorodecalin was found to increase the microsomal glutathione S-transferase and UDP-glucuronosyltransferase activities 1.4- and 2.3-fold, respectively. The activity of sulphotransferase was decreased 2-fold. These results show that perfluorodecalin is an inducer of both the enzymes of cytochrome P-450-dependent monooxygenase system [Mishin V. et al (1989) Chem.-Biol. Interactions, 72, 143-155.] and those catalyzing conjugation reactions: microsomal glutathione S-transferase and UDP-glucuronosyltransferase.
authors.affiliation: All-Union Research Institute of Biotechnology, Nauchyi Proiezd, Moscow, USSR.
authors.forename: E V
authors.initials: EV
authors.lastname: Kalinina
authors.forename: V V
authors.initials: VV
authors.lastname: Obraztsov
authors.forename: D G
authors.initials: DG
authors.lastname: Shekhtman
authors.forename: O V
authors.initials: OV
authors.lastname: Gudkova
authors.forename: N I
authors.initials: NI
authors.lastname: Kukushkin
authors.forename: A N
authors.initials: AN
authors.lastname: Saprin
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004655:Emulsions; D005466:Fluorocarbons / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008658:Inactivation, Metabolic; D007275:Injections, Intravenous; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015238:Sulfotransferases / Q000378:metabolism*; D015262:Xenobiotics
chemical_list: D004655:Emulsions; D005466:Fluorocarbons; D015262:Xenobiotics; C008805:perfluorodecalin; D003577:Cytochrome P-450 Enzyme System; C019781:benzphetamine N-demethylase; D010089:Oxidoreductases, N-Demethylating; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; D015238:Sulfotransferases