title: A randomized comparative study for the clinical evaluation of hormone replacement by transdermal and oral routes.
abstract: During a six-month randomized study involving 460 post-menopausal women, transdermal estradiol has proved to be as effective as oral conjugated equine estrogens in the control of menopausal symptoms and to produce similar estrogenic effects on the endometrium. The group of patients treated with transdermal estradiol showed better compliance and had fewer drop-outs. Moreover, the quality and duration of menstrual bleeding were considered more physiological in the transdermal estradiol group than in the orally treated patients. The trial was carried out with the co-operation of 17 Italian University Centres, under the supervision of Ciba-Geigy Italy S.p.A. Medical Department.
authors.affiliation: Dipartimento Medico Ciba Geigy S.p.A. Origgio, Varese.
authors.forename: F
authors.initials: F
authors.lastname: Polvani
authors.forename: L
authors.initials: L
authors.lastname: Zichella
authors.forename: A
authors.initials: A
authors.lastname: Bocci
authors.forename: F
authors.initials: F
authors.lastname: Bottiglioni
authors.forename: G
authors.initials: G
authors.lastname: Cagnazzo
authors.forename: C
authors.initials: C
authors.lastname: Campagnoli
authors.forename: L
authors.initials: L
authors.lastname: Carenza
authors.forename: S
authors.initials: S
authors.lastname: Cianci
authors.forename: V
authors.initials: V
authors.lastname: Danesino
authors.forename: L
authors.initials: L
authors.lastname: De Cecco
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D004958:Estradiol / Q000008:administration & dosage* / Q000097:blood; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D006801:Humans; D008593:Menopause / Q000097:blood / Q000187:drug effects; D008875:Middle Aged
chemical_list: D004967:Estrogens; D004958:Estradiol