title: Interference of AlF4- with nucleotide and DNA binding of rat histone H1 in vitro. Implications for the pathogenesis of Alzheimer's disease.
abstract: We demonstrate here that the H2PO4- analogue AlF4- binds to the nucleotide-binding site of rat liver histone H1 in vitro, and interferes with nucleotide recognition and H1 DNA binding. AlF4- may thus compromise the genetically determined pattern of protein synthesis through binding to H1, the general repressor. The present findings are of interest as a number of studies have implicated aluminium as a factor in the pathogenesis of Alzheimer's disease.
authors.affiliation: Collagen Research Unit, University of Oulu, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Oikarinen
authors.forename: R M
authors.initials: RM
authors.lastname: Mannermaa
authors.forename: T
authors.initials: T
authors.lastname: Tarkka
authors.forename: N
authors.initials: N
authors.lastname: Yli-Mäyry
authors.forename: K
authors.initials: K
authors.lastname: Majamaa
mesh_terms: D000535:Aluminum / Q000494:pharmacology*; D017607:Aluminum Compounds; D000544:Alzheimer Disease / Q000209:etiology*; D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D005459:Fluorides; D005461:Fluorine / Q000494:pharmacology*; D006657:Histones / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism*; D051381:Rats
chemical_list: D017607:Aluminum Compounds; D006657:Histones; D009711:Nucleotides; C050992:tetrafluoroaluminate; D005461:Fluorine; D004247:DNA; D000535:Aluminum; D005459:Fluorides