Acute motor neuropathy with antibodies to GM1 ganglioside.
We describe a 52-year-old man who had an acute-onset purely motor neuropathy fulfilling the diagnostic criteria for the Guillain-Barré syndrome, in whom virtually complete spontaneous recovery occurred by 1 year, and in whom high titres of polyclonal serum antibody to GM1, GD1b, asialo-GM1 and lacto-N-tetraose were detected. The titre of IgM antibody to GM1 fell during the course of the disease with a concomitant rise in the IgG titre. This case adds to the widening spectrum of disease associated with anti-GM1 antibodies and provides further evidence for a relationship between anti-GM1 antibodies and motor system disease.
Gregson
N A
NA
Department of Anatomy, United Medical School, Royal Free Hospital School of Medicine, London, UK.
Jones
D
D
Thomas
P K
PK
Willison
H J
HJ
D000208:Acute Disease; D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011129:Polyradiculoneuropathy / Q000276:immunology*; D011901:Ranvier's Nodes / Q000276:immunology; D051381:Rats
D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005677:G(M1) Ganglioside