title: Two-stage resuscitation of the cat brain after prolonged cardiac arrest.
abstract: Following prolonged cardiac arrest, reperfusion of the brain is endangered by the low blood perfusion pressure during the early resuscitation phase. In order to avoid low perfusion brain injury, a two-stage resuscitation protocol was applied to cats submitted to 30 min potassium chloride induced cardiac arrest: first, the heart was resuscitated, followed--after stabilisation of blood pressure--by recirculation of the brain. During cardiac resuscitation the brain was disconnected from the general circulation by inflating a pneumatic cuff around the neck. The results were compared with the outcome of conventional one-stage resuscitation following 15 min cardiac arrest. Cardiac resuscitation was successful in 5 out of 8 animals with 15 min and in 6 out of 13 animals with 30 min cardiac arrest. In successfully resuscitated animals of both groups, brain energy metabolism recovered to normal within 3 h although two-stage resuscitation increased brain ischemia time to 37-61 min. Two-stage resuscitation, in consequence, is a promising approach for revival of the brain after prolonged cardiac arrest.
authors.affiliation: Department of Anesthesiology, Yamaguchi Rousai Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Seo
authors.forename: S
authors.initials: S
authors.lastname: Ishimaru
authors.forename: K A
authors.initials: KA
authors.lastname: Hossmann
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D001923:Brain Chemistry; D016887:Cardiopulmonary Resuscitation / Q000379:methods / Q000592:standards*; D002415:Cats; D002560:Cerebrovascular Circulation; D004569:Electroencephalography; D004594:Electrophysiology; D004734:Energy Metabolism; D005069:Evaluation Studies as Topic; D005073:Evoked Potentials, Somatosensory; D005260:Female; D005947:Glucose / Q000737:chemistry; D006323:Heart Arrest / Q000150:complications*; D006863:Hydrogen-Ion Concentration; D002534:Hypoxia, Brain / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007773:Lactates / Q000737:chemistry; D019344:Lactic Acid; D008297:Male
chemical_list: D007773:Lactates; D019344:Lactic Acid; D000255:Adenosine Triphosphate; D005947:Glucose