Biological changes in the regenerating and intact rat liver following exposure of the organ to lasers.
This study is among the first employing anatomical partial hepatectomy and exposure of the remnant organ to lasers before closure for comparison of biological changes with those of exposed sham-operated groups and the respective controls. Adult male rats were partially hepatectomized leading to removal of two-thirds of the organ and the lateral lobe exposed to Argon (514 nm, 270 mW-3.0 W for up to 120 s; tunable dye, 630 nm, 200 and 500 mW for up to 240 s) and Nd:YAG (1064 nm; 3-8 W, 60-180 s) lasers. Sham-operated rats were treated similarly and with several, 1 or 2 additional sites in the quadrate lobes were irradiated. Possibly, liver damage and penetrability were somewhat greater for the intact rats treated with the Nd:YAG laser and which also displayed liver profile changes over the controls in contrast to the partially hepatectomized. In general, the extent of liver regeneration over a period of 10 days post-operative was not affected by the laser treatment. The mixed function oxidase system reflected small decrements in aminopyrine demethylase and in benzo[a]pyrene hydroxylase for adjacent lesion-free microsomes from the partially hepatectomized and intact groups exposed to Nd:YAD laser (5.0 W, 120 s), respectively.
Gershbein
L L
LL
Northwest Institute for Medical Research, John F. Kennedy Health Care Corporation, Chicago, IL.
Denton
R W
RW
Schifano
M J
MJ
D000818:Animals; D006498:Hepatectomy; D007834:Lasers / Q000009:adverse effects*; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000473:pathology / Q000528:radiation effects*; D008115:Liver Regeneration; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000528:radiation effects; D009929:Organ Size / Q000528:radiation effects; D051381:Rats; D011919:Rats, Inbred Strains; D014466:Ultraviolet Rays / Q000009:adverse effects
D008055:Lipids