title: Normal pregnancy after curative multiagent chemotherapy for choriocarcinoma with brain metastases.
abstract: A case is reported of a metastatic gestational choriocarcinoma in a 25-year old woman. Extensive pelvic, pulmonary and brain metastases were associated with clinically manifest thyrotoxicosis. Multiagent chemotherapy alone was successful in achieving a durable remission and euthyroid state. The chemotherapy regimen consisted of cis-platinum, etoposide, actinomycin-D, and intrathecal methotrexate (PEA-M). The Patient conceived 2 years after completing therapy and gave birth at term to a normal infant.
authors.affiliation: King Faisal Gestational Trophoblastic Center, Section of Gynecologic Oncology, Riyadh, Saudi Arabia.
authors.forename: Y N
authors.initials: YN
authors.lastname: Bakri
authors.forename: P
authors.initials: P
authors.lastname: Pedersen
authors.forename: M
authors.initials: M
authors.lastname: Nassar
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D002822:Choriocarcinoma / Q000188:drug therapy* / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008727:Methotrexate / Q000008:administration & dosage; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced*; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D003609:Dactinomycin; D005047:Etoposide; D002945:Cisplatin; D008727:Methotrexate