title: Endothelin-binding inhibitors, BE-18257A and BE-18257B II. Structure determination.
abstract: The structures of novel endothelin-binding inhibitors, BE-18257A and BE-18257B, were elucidated by spectral analyses and chemical studies. Both inhibitors were found to have a cyclic pentapeptide structure containing three D-form amino acid residues, namely, the structures of BE-18257A and BE-18257B were elucidated to be cyclo(-D-Glu-L-Ala-D-Val-L-Leu-D-Trp-) and cyclo(-D-Glu-L-Ala-allo-D-Ile-L-Leu-D-Trp-), respectively.
authors.affiliation: Central Research, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakajima
authors.forename: K
authors.initials: K
authors.lastname: Niiyama
authors.forename: M
authors.initials: M
authors.lastname: Ihara
authors.forename: K
authors.initials: K
authors.lastname: Kojiri
authors.forename: H
authors.initials: H
authors.lastname: Suda
mesh_terms: D016232:Endothelins / Q000378:metabolism*; D009842:Oligopeptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry*
chemical_list: D016232:Endothelins; D009842:Oligopeptides; D010456:Peptides, Cyclic; C072732:cyclo(valyl-leucyl-tryptophyl-glutamyl-alanyl); C069764:cyclo(glutamyl-alanyl-isoleucyl-leucyl-tryptophyl)