title: Uterine motility and cervical ripening in second trimester elective abortion by two different PGE analogues.
abstract: The clinical effects were studied of two different PGE analogues on the uterine motility and cervical ripening of eighty pregnant women asking for a second trimester elective abortion for fetal abnormalities. Forty women received vaginal suppositories each containing 1 milligram of 16, 16-dimethyl-trans-s2-PGE1 (Gemeprost) every 3 hours (5 mg max). Intramuscular injections of 500 micrograms of 16-phenoxy-w 17, 18, 19, 20 tetranor PGE2 methyl-sulphonylamide (Sulprostone) were administered every four hours (2000 mcg max.) to the remaining forty patients. Thirty-three Gemeprost treated patients (82.5%) and 34 Sulprostone treated patients (85%) experienced a complete abortion in the mean of 12.92 +/- 6.95 hours and 11.88 +/- 6.8 hours respectively. The histological and ultrastructural findings of cervical ripening were similar in both groups, while the tocographic patterns showed different characteristics. Side effects occurred in 16 Sulprostone (40%), but only in 9 (22.5%) Gemeprost treated patients, demonstrating that Gemeprost, although equally effective, is better tolerated.
authors.affiliation: II Medical School, Department of Gynecology and Obstetrics, University of Naples Federico II.
authors.forename: A
authors.initials: A
authors.lastname: Di Lieto
authors.forename: D
authors.initials: D
authors.lastname: Catalano
authors.forename: G
authors.initials: G
authors.lastname: Albano
authors.forename: N
authors.initials: N
authors.lastname: Uccello
authors.forename: A
authors.initials: A
authors.lastname: Civetta
authors.forename: R
authors.initials: R
authors.lastname: Ferrara
authors.forename: R
authors.initials: R
authors.lastname: Fimiani
authors.forename: M
authors.initials: M
authors.lastname: Pontillo
authors.forename: A
authors.initials: A
authors.lastname: Paladini
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D002584:Cervix Uteri / Q000502:physiology / Q000648:ultrastructure; D015232:Dinoprostone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007745:Labor Onset / Q000187:drug effects*; D008854:Microscopy, Electron; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: C021182:gemeprost; C016767:sulprostone; D000527:Alprostadil; D015232:Dinoprostone