The protein translocation apparatus of the rough endoplasmic reticulum, its associated proteins, and the mechanism of translocation.
The demonstration that the yeast Sec61, Sec62, and Sec63 proteins are assembled into a multisubunit complex in the yeast endoplasmic reticulum was of particular significance in a year when protein, and nucleic-sequence analyses revealed interesting homologies between pathways of protein transport in mammals and yeast, and possibly in Escherichia coli.
Gilmore
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Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01655.
D000818:Animals; D001692:Biological Transport; D004285:Dogs; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005800:Genes, Fungal; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D008322:Mammals / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D021382:Protein Sorting Signals / Q000502:physiology; D011506:Proteins / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics; D012697:Serine Endopeptidases
D005656:Fungal Proteins; D006023:Glycoproteins; D008565:Membrane Proteins; D021382:Protein Sorting Signals; D011506:Proteins; D006160:Guanosine Triphosphate; D010450:Endopeptidases; D012697:Serine Endopeptidases; C026515:type I signal peptidase