[Diabetes insipidus and Langerhans-cell histiocytosis without changes in cerebral CAT and NMR].
In LCH extended disease CNS involvement in is not infrequent. Diabetes insipidus, due to the affectation of hypothalamus-hypophysis axis, is its most frequent finding. The solitary affectation of hypothalamus-hypophysis axis is exceptional. At times, it's a difficult diagnosis and could precede the diagnosis of LCH several years. Usually, CAT and NMR show morphologic lesions. We report a patient who was diagnosed of idiopathic diabetes insipidus when he was 16 years old. Seven year later, he was diagnosed of LCH after underwent a bone marrow biopsy examination, just when the disease involved the bone and lung. Cerebral CAT and NMR didn't show morphologic lesions. In the presence of morphologic lesions in hypothalamus and/or hypophysis, proved by cerebral CAT and NMR, or a clinical setting of DI, the possibility of LCH must be considered.
Muñoz Méndez
J
J
Servicio de Neumología, Hospital La Paz, Universidad Autónoma, Madrid.
Ortega Cuesta
B
B
García Rubio
B
B
de Ramón Casado
A
A
Vázquez Mezquita
M
M
Fernández Francés
J
J
González Ruiz
J M
JM
Díaz Lobato
S
S
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D001856:Bone Marrow Examination; D001842:Bone and Bones / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging*; D003919:Diabetes Insipidus / Q000209:etiology*; D003937:Diagnosis, Differential; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed
Diabetes insípida en histiocitosis de células de Langerhans, sin alteraciones en la TAC y RMN cerebral.