title: New cytotoxic beta-carboline alkaloids from the marine bryozoan, Cribricellina cribraria.
abstract: Bioactivity-directed separations led to the isolation of the new alkaloid, 1-vinyl-8-hydroxy-beta-carboline [1], as the major cytotoxic component of the marine bryozoan Cribricellina cribraria. Another new beta-carboline alkaloid 2 with the novel sulfone structure was isolated, together with a number of known beta-carboline compounds. Cytotoxicity and antimicrobial effects are reported for these compounds and for other synthesized beta-carbolines.
authors.affiliation: Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
authors.forename: M R
authors.initials: MR
authors.lastname: Prinsep
authors.forename: J W
authors.initials: JW
authors.lastname: Blunt
authors.forename: M H
authors.initials: MH
authors.lastname: Munro
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification; D001419:Bacteria / Q000187:drug effects; D002013:Bryozoa / Q000032:analysis*; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D014780:Viruses / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents