title: Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the beta-amyloid sequence.
abstract: A mutation within exon 17 at codon 717 of the beta-amyloid protein precursor (APP) gene is one cause of early onset familial Alzheimer's disease. Direct sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene in 14 families with familial early onset Alzheimer's disease without the known pathogenic mutation (APP717) failed to reveal other mutations within the beta-amyloid sequence in this form of the disorder.
authors.affiliation: Department of Biochemistry, St. Mary's Hospital Medical School, London, U.K.
authors.forename: F
authors.initials: F
authors.lastname: Crawford
authors.forename: J
authors.initials: J
authors.lastname: Hardy
authors.forename: M
authors.initials: M
authors.lastname: Mullan
authors.forename: A
authors.initials: A
authors.lastname: Goate
authors.forename: D
authors.initials: D
authors.lastname: Hughes
authors.forename: L
authors.initials: L
authors.lastname: Fidani
authors.forename: P
authors.initials: P
authors.lastname: Roques
authors.forename: M
authors.initials: M
authors.lastname: Rossor
authors.forename: M C
authors.initials: MC
authors.lastname: Chartier-Harlin
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D001483:Base Sequence; D005091:Exons; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation
chemical_list: C094559:APP717; D016564:Amyloid beta-Protein Precursor