title: Limb function following conservation treatment of adult soft tissue sarcoma.
abstract: Quality of life and limb function were studied in 54 patients who were disease-free 2 or more years after limb-conserving treatment for soft tissue sarcoma of the leg or pelvic girdle. Tumours of the thigh predominated (25 patients) and the mean tumour size was 9.9 cm. 41 patients had been treated with a combination of surgery and radiotherapy (29 with conventional and 12 with high dose), 12 with surgery alone and one with irradiation and intra-arterial doxorubicin. Only 15 patients had a normal range of movement in all lower limb joints and only 12 had normal power in all muscle groups; tumours of the lower leg were particularly unfavourable in this respect. Gait was normal in 42 patients but 8 required a walking aid and 4 a joint support. 16 had detectable lymphoedema but only 2 needed to wear compression hosiery. 35 patients still experienced pain at some time but only 6 required analgesia. However, when assessed by questionnaire for locomotion, grooming and home/leisure/vocational activities, 37 patients (68%) reported excellent function, and only 2 had moderate impairment. Function loss was most marked in leisure (25 patients) and vocational (8) activities, but was mild in 66% of cases. Multivariate analysis was carried out to determine the prognostic factors for poor limb function. The results suggested that overall functional score was predominantly determined by gait (P less than 0.001), muscle power or range of movement (P less than 0.001), with increasing age, female sex and the use of radiotherapy poor prognostic factors. Reduced muscle power or range of movement were the major factors determining gait (P less than 0.02) with the use of radiotherapy the significant prognostic factor for both in the conventionally treated group. Doses in excess of 60 Gy resulted in increased fibrosis and a worse functional outcome. Extent of surgery was not an independent prognostic factor for limb function, although univariate analysis suggested an association with range of movement in the conventionally treated group (P less than 0.025). Despite significant objective loss of range of movement and muscle power patients retain excellent limb function and quality of life following limb conserving treatment. For optimal function, radiotherapy should be given with small fractions to a dose not exceeding 60 Gy.
authors.affiliation: Department of Radiotherapy, Royal Marsden Hospital, London.
authors.forename: M H
authors.initials: MH
authors.lastname: Robinson
authors.forename: L
authors.initials: L
authors.lastname: Spruce
authors.forename: R
authors.initials: R
authors.lastname: Eeles
authors.forename: I
authors.initials: I
authors.lastname: Fryatt
authors.forename: C L
authors.initials: CL
authors.lastname: Harmer
authors.forename: J M
authors.initials: JM
authors.lastname: Thomas
authors.forename: G
authors.initials: G
authors.lastname: Westbury
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D005684:Gait; D006801:Humans; D007866:Leg / Q000601:surgery*; D008209:Lymphedema / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009068:Movement; D009132:Muscles / Q000503:physiopathology; D011183:Postoperative Complications / Q000209:etiology; D011379:Prognosis; D011788:Quality of Life; D012509:Sarcoma / Q000532:radiotherapy / Q000534:rehabilitation* / Q000601:surgery