[The effect of pharmacological agents on the rate of lymph outflow and on blood and lymph toxicity in acute myocardial infarct].
In experiments on rabbits it was found that acute myocardial infarction (AMI) was associated with a disorder of the drainage function the lymphatic system and a drastic increase of the lymph toxicity. The administration of propranolol (obsidan), amiodaron (cordaron), lidocaine (xycaine), trimecaine (mesocaine), nitroglycerin, panangin and heparin exerted the pronounced stimulating action on the lymph outflow rate. Strophanthin-K, corglycon and digo in possessed the moderate lymphogenic effect. Novocainamide (procainamide), verapamil (isoptine) and panangin exerted no influence on the lymph outflow rate. The administration of the above mentioned drugs in the initial period of AMI sharply increased the toxic properties of the lymph; subsequently the lymph toxicity gradually decreased and was less than in control (in AMI treated with drugs).
Ismailova
Z D
ZD
Mamedov
Ia D
IaD
Guseĭnov
D Ia
DIa
Garaev
G Sh
GSh
D000818:Animals; D001769:Blood / Q000187:drug effects* / Q000276:immunology; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008196:Lymph / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D011817:Rabbits; D013897:Thoracic Duct / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D002317:Cardiovascular Agents
Vliianie nekotorykh farmakologicheskikh sredstv na skorost' limfoottoka, toksichnost' krovi i limfy pri ostrom infarkte miokarda.