Clindamycin in the treatment of anaerobic lung abscess.
A case of anaerobic lung abscess who had treatment failure after 4 weeks of supervised parenteral penicillin and oral metronidazole is described. Anaerobic pathogens resistant to one or the other of the above drugs were isolated. The patient had a striking clinical response to subsequent therapy with oral clindamycin. Failure of therapy should alert physicians to the possibility of infection with resistant anaerobic pathogens and in such situations, clindamycin is considered as an effective alternative.
Shah
A
A
Department of Clinical Research, Vallabhbhai Patel Chest Institute, Delhi.
Sircar
M
M
Bhagat
R
R
Jaiswal
A
A
Thukral
S S
SS
D000328:Adult; D001421:Bacteria, Anaerobic / Q000187:drug effects / Q000302:isolation & purification; D002981:Clindamycin / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006801:Humans; D008169:Lung Abscess / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D010403:Penicillin Resistance; D010406:Penicillins / Q000627:therapeutic use
D010406:Penicillins; D008795:Metronidazole; D002981:Clindamycin