[Study of blood pressure response to exertion in essential hypertension. Its modification with anti-hypertensive treatment].
We have studied the effect of atenolol, xipamide, and verapamil in the control of effort tensional response in 54 patients suffering essential hypertension. A first effort test without treatment and a second after a one month treatment randomly assigned were performed in all patients, evaluating the tensional response at 30, 60 and 80 Watts of charge, maximum peak, and after five minutes in recovery. Atenolol significantly reduced (p less than 0.05) systolic arterial pressure and diastolic arterial pressure in every intermediate effort stage, maximum peak and post effort recovery, xipamide, also significantly reduced (p less than 0.05) the systolic hypertensive response at all different levels, however, the diastolic one did not reach any statistic significance. Verapamil at used doses did not modify neither systolic nor diastolic hypertensive response. The beneficial effect of beta-blockers is confirmed although we could not confirm the effect pointed out by other authors regarding calcium antagonists. Tensional control using xipamide was striking although there is some evidence to think that it can have a more important effect in the control than thiazide diuretics or amiloride.
Soria Arcos
F
F
Facultad de Medicina, Hospital General de Murcia.
Alegría Ezquerra
E
E
Valdés Chávarri
M
M
García Alberola
A
A
Vicente Vera
T
T
Pérez Lorente
F
F
Apellaniz Sáinz-Trápaga
G
G
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion / Q000502:physiology*
D000959:Antihypertensive Agents
Estudio de la respuesta tensional al esfuerzo en hipertensos esenciales. Su modificación con el tratamiento antihipertensivo.