Effects of canrenone on RRM-sucrose hypertension in WKY.
Ingestion of a diet high in sucrose content by WKY rats having reduced renal mass (RRM) via a unilateral nephrectomy causes a significant elevation of BP--greater than might be expected from either condition alone. The same findings occur whether the added sucrose calories replace protein or fat. The elevated BP differential remained throughout the 6 months of the study. In some ways, these results resemble a well recognized model of hypertension produced by the removal of 70-80% of renal mass plus excess salt consumption (RRM-salt). When the RRM-sucrose WKY were given canrenone, an agent which is a digoxin antagonist, the BP decreased significantly simulating previous findings in RRM-salt. Therefore, like the RRM-salt model, evidence suggests that the RRM-sucrose model is also caused, at least in part, by a digoxin-like factor (DLF).
Preuss
H G
HG
Department of Medicine (Nephrology Division), Georgetown University Medical Center, Washington, D.C.
al Karadaghi
P
P
Yousufi
A
A
MacArthy
P
P
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002192:Canrenone / Q000627:therapeutic use*; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D007668:Kidney / Q000502:physiology*; D009392:Nephrectomy; D051381:Rats; D011921:Rats, Inbred WKY; D012982:Sodium, Dietary / Q000009:adverse effects; D013395:Sucrose / Q000009:adverse effects*
D004040:Dietary Carbohydrates; D012982:Sodium, Dietary; D013395:Sucrose; D002192:Canrenone