Involvement of the amygdala in the memory-enhancing effects of clenbuterol.
Male Sprague Dawley rats with stria terminalis (ST) or sham lesions were trained in an inhibitory avoidance task, injected immediately post-training with clenbuterol hydrochloride (0.03 mg/kg; IP), and tested for retention 48 h later. Clenbuterol enhanced retention of the sham-lesioned animals but did not affect retention of the ST-lesioned animals. Clenbuterol injected intraamygdally immediately after training also enhanced retention of the inhibitory avoidance task. These results agree with other evidence suggesting the participation of beta-noradrenergic mechanisms in the amygdala in the modulation of memory storage.
Introini-Collison
I B
IB
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.
Miyazaki
B
B
McGaugh
J L
JL
D000679:Amygdala / Q000033:anatomy & histology / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002404:Catheterization; D002976:Clenbuterol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D002976:Clenbuterol