Adjuvant effects of beta-adrenergic drugs on indomethacin treatment of newborn canine endotoxic shock.
Newborns are susceptible to gram-negative sepsis/septic shock, but there is no established method of its treatment. This study was performed to evaluate the adjuvant effects of dopamine and dobutamine in the indomethacin treatment of newborn endotoxic shock. Endotoxic shock was induced in newborn dogs (2 to 10 days old; 300 to 800 g) by Escherichia coli lipopolysaccharide (LPS; 1.5 mg/kg, intravenously [IV]). Indomethacin (1.5 mg/kg, IV) was injected 5 minutes after LPS injection. Dopamine (5 micrograms/kg/min) or dobutamine (5 micrograms/mg/min) infusion started 5 minutes after LPS injection immediately following indomethacin injection. Hemodynamic parameters were monitored serially for 120 minutes. LPS induced bradycardia and hypotension, decreased the cardiac output and cardiac performance, and increased the total vascular resistance. When dopamine, dobutamine, or indomethacin were used alone, they attenuated the hemodynamic deterioration by LPS. Dopamine infusion following indomethacin administration improved the hemodynamics further, although dobutamine infusion did not. Therefore, we conclude that the adjuvant therapy of dopamine in the indomethacin treatment of newborn endotoxic shock is beneficial.
Goto
M
M
Department of Pediatrics, Loyola University Stritch School of Medicine, Maywood, IL 60153.
Griffin
A
A
D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000831:Animals, Newborn; D004280:Dobutamine / Q000494:pharmacology / Q000627:therapeutic use*; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004926:Escherichia coli; D006439:Hemodynamics / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use*; D008070:Lipopolysaccharides; D012772:Shock, Septic / Q000188:drug therapy* / Q000209:etiology
D000277:Adjuvants, Pharmaceutic; D008070:Lipopolysaccharides; D004280:Dobutamine; D004298:Dopamine; D007213:Indomethacin