Fat-soluble vitamins in infants identified by cystic fibrosis newborn screening.
Fat-soluble vitamin status was assessed in 36 infants diagnosed with cystic fibrosis by newborn screening in the Colorado Program. At the time of diagnosis of cystic fibrosis, 36% of infants were hypoalbuminemic, 21% had vitamin A deficiency, 35% had vitamin D deficiency, and 38% had vitamin E deficiency. None had vitamin K deficiency. Supplementation with pancreatic enzymes, a multiple vitamin preparation, and additional vitamin E was associated with normalization of serum albumin, retinol, and 25-hydroxyvitamin D and negative PIVKA testing at age 6 and 12 months. Several patients remained vitamin E deficient, but this was felt to be due to poor compliance. Biochemical evidence of fat-soluble vitamin deficiency is common before age 3 months in infants with CF and responds to supplementation in the first year of life.
Sokol
R J
RJ
Department of Pediatric Gastroenterology and Nutrition, University of Colorado Health Sciences Center, Denver.
Reardon
M C
MC
Accurso
F J
FJ
Stall
C
C
Narkewicz
M R
MR
Abman
S H
SH
Hammond
K B
KB
D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015997:Neonatal Screening; D010194:Pancreatin / Q000627:therapeutic use; D014802:Vitamin A Deficiency / Q000188:drug therapy / Q000209:etiology*; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000209:etiology*; D014810:Vitamin E / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000188:drug therapy / Q000209:etiology*; D014815:Vitamins / Q000627:therapeutic use
D014815:Vitamins; D014810:Vitamin E; D010194:Pancreatin