Effect of perfluorodecalin on activities of hepatic phase II xenobiotic biotransformation enzymes.
The activity of the hepatic phase II enzymes of xenobiotic biotransformation after intravenous administration of perfluorodecalin emulsion to rats was measured. Perfluorodecalin was found to increase the microsomal glutathione S-transferase and UDP-glucuronosyltransferase activities 1.4- and 2.3-fold, respectively. The activity of sulphotransferase was decreased 2-fold. These results show that perfluorodecalin is an inducer of both the enzymes of cytochrome P-450-dependent monooxygenase system [Mishin V. et al (1989) Chem.-Biol. Interactions, 72, 143-155.] and those catalyzing conjugation reactions: microsomal glutathione S-transferase and UDP-glucuronosyltransferase.
Kalinina
E V
EV
All-Union Research Institute of Biotechnology, Nauchyi Proiezd, Moscow, USSR.
Obraztsov
V V
VV
Shekhtman
D G
DG
Gudkova
O V
OV
Kukushkin
N I
NI
Saprin
A N
AN
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004655:Emulsions; D005466:Fluorocarbons / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008658:Inactivation, Metabolic; D007275:Injections, Intravenous; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015238:Sulfotransferases / Q000378:metabolism*; D015262:Xenobiotics
D004655:Emulsions; D005466:Fluorocarbons; D015262:Xenobiotics; C008805:perfluorodecalin; D003577:Cytochrome P-450 Enzyme System; C019781:benzphetamine N-demethylase; D010089:Oxidoreductases, N-Demethylating; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; D015238:Sulfotransferases