title: Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine.
abstract: We report the case of a patient who developed myoclonus and hyperalgesia following administration of high-dose subarachnoid morphine. This complication occurred with 40-80 mg/day continuous infusion. The pathophysiology of these side effects is discussed.
authors.affiliation: Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, 20133 Milan Italy Department of Radiology, National Cancer Institute of Milan, 20133 Milan Italy Palliative Care Unit, USSL 75 / IV, 20143 Milan Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: de Conno
authors.forename: Augusto
authors.initials: A
authors.lastname: Caraceni
authors.forename: Cinzia
authors.initials: C
authors.lastname: Martini
authors.forename: Elio
authors.initials: E
authors.lastname: Spoldi
authors.forename: Monica
authors.initials: M
authors.lastname: Salvetti
authors.forename: Vittorio
authors.initials: V
authors.lastname: Ventafridda
mesh_terms: D004334:Drug Administration Schedule; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced*; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D009207:Myoclonus / Q000139:chemically induced*
chemical_list: D009020:Morphine