Alcohol and anesthetic actions on myocardial contractility. Evidence for a lipophilic/electrophilic sarcoplasmic reticulum site.
Lynch
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Department of Anesthesiology, University of Virginia Health Sciences Center, Charlottesville 22908.
D000200:Action Potentials / Q000187:drug effects; D000438:Alcohols / Q000494:pharmacology*; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D011343:Procaine / Q000494:pharmacology; D012433:Ryanodine / Q000494:pharmacology; D012519:Sarcoplasmic Reticulum / Q000737:chemistry / Q000187:drug effects*; D012964:Sodium / Q000494:pharmacology
D000438:Alcohols; D000777:Anesthetics; D012433:Ryanodine; D011343:Procaine; D012964:Sodium; D007545:Isoproterenol; D002118:Calcium