An immunohistochemical study of the collagens of rabbit synovial interstitium.
The interstitial pathway from joint cavity to synovial transport vessels contains a complex extracellular matrix. Rabbit knee synovial intima contains 3 fibrous elements--banded collagen fibrils, microfibrils and broad banded aggregates. The distribution of 4 types of collagen in rabbit knee synovium was investigated immunohistochemically. Types I and III collagens are both present, although the binding of anti-type I antibody was weak. Type V collagen, which forms thin fibrils, or is copolymerized with type I collagen, and type VI collagen, which forms broad banded aggregates and microfibrils, are widely distributed throughout the intimal and subintimal matrices.
Ashhurst
D E
DE
Department of Anatomy, St. George's Hospital Medical School, London, UK.
Bland
Y S
YS
Levick
J R
JR
D000818:Animals; D000911:Antibodies, Monoclonal; D003094:Collagen / Q000378:metabolism*; D007150:Immunohistochemistry; D011817:Rabbits; D013583:Synovial Membrane / Q000166:cytology / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D003094:Collagen