title: The concentration of the cross-linking agent as a tool for the control of release and swelling properties of gelatin microspheres.
abstract: The effect of the concentration of a cross-linking agent (gelatin hardener) on gelatin microspheres was evaluated. A concentration increase of the gelatin hardener (formaldehyde) produced a decrease of drug loading, swelling degree and drug release rate. The cross-linking agent concentration affected also the kinetics of water absorption and drug release. This paper suggests a decreasing significance of the diffusion-type mechanism of drug release as the concentration of the cross-linking agent increased.
authors.affiliation: Department of Pharmaceutical Sciences, University of Modena, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Vandelli
authors.forename: F
authors.initials: F
authors.lastname: Forni
authors.forename: V
authors.initials: V
authors.lastname: Iannuccelli
authors.forename: R
authors.initials: R
authors.lastname: Cameroni
mesh_terms: D002214:Capsules / Q000737:chemistry*; D003432:Cross-Linking Reagents; D005780:Gelatin / Q000737:chemistry*
chemical_list: D002214:Capsules; D003432:Cross-Linking Reagents; D005780:Gelatin