The effect of age on glucuronidation and sulphation of paracetamol by human liver fractions.
Glucuronidation and sulphation were studied in vitro in human liver samples from 22 subjects aged 40-89 years using paracetamol as substrate. There was no significant correlation with age for the activity of either enzyme pathway. These results provide further evidence that age per se does not have a major effect on the activities of hepatic metabolising enzymes.
Herd
B
B
Department of Medicine (Geriatrics), The University, Newcastle upon Tyne.
Wynne
H
H
Wright
P
P
James
O
O
Woodhouse
K
K
D000082:Acetaminophen / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008875:Middle Aged; D015238:Sulfotransferases / Q000378:metabolism
D000082:Acetaminophen; D014453:Glucuronosyltransferase; D015238:Sulfotransferases