Synthesis, characterization, and cytotoxic studies of alpha-diimine/1,2-diamine platinum(II) and palladium(II) complexes of selenite and tellurite and binding of some of these complexes to DNA.
Eleven new complexes of formula [M(NN)(XO3)] (where M is Pd(II) or Pt(II); NN is 2,2'-bipyridine, 1,10-phenanthroline, 2,2'-dipyridylamine, ethylenediamine or (+-)trans-1,2-diaminocyclohexane, and XO3(2-) is SeO3(2-) or TeO3(2-)) have been synthesized. These water soluble complexes have been characterized by chemical analysis and conductivity measurements as well as ultraviolet-visible and infrared spectroscopy. In these complexes the selenite or tellurite ligand coordinates to platinum(II) or palladium(II) as bidentate with two oxygen atoms. These complexes inhibit the growth of P 388 lymphocytic leukemia cells, their targets are DNA. The selenite complexes invariably show I.D.50 values less than cisplatin. However, the I.D.50 values of the tellurite complexes are usually higher than cisplatin, except that of [Pd(dach)(TeO3)] which has comparable I.D.50 values, as compared to cisplatin. [Pt(bipy)(SeO3)] and [Pd(bipy)(SeO3)] have been interacted with calf thymus DNA and bind to DNA through a coordinate covalent bond.
Mansuri-Torshizi
H
H
Department of Chemistry, Indian Institute of Technology, Powai, Bombay.
Mital
R
R
Srivastava
T S
TS
Parekh
H
H
Chitnis
M P
MP
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D004247:DNA / Q000378:metabolism*; D003959:Diamines / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D007941:Leukemia P388 / Q000188:drug therapy; D010165:Palladium / Q000737:chemistry* / Q000627:therapeutic use; D010984:Platinum / Q000737:chemistry* / Q000627:therapeutic use; D020887:Selenious Acid; D012643:Selenium / Q000737:chemistry*; D013053:Spectrophotometry; D013691:Tellurium / Q000737:chemistry*
D000970:Antineoplastic Agents; D003959:Diamines; D007097:Imines; D010984:Platinum; D010165:Palladium; D004247:DNA; D020887:Selenious Acid; D012643:Selenium; D013691:Tellurium; D002945:Cisplatin