[The effect of the flesinoxan subtype of serotonin C1a receptor agonist on the arterial pressure in rats].
The effect of a high-affinity C1A serotonin receptor agonist flesinoxan on the arterial blood pressure and the heart rate in normotensive Wistar rats, spontaneously hypertensive rats and inherited stress-induced arterial hypertension rats was studied. It was shown that both peripheral and central administration of flesinoxan produces a decrease of blood pressure and heart rate. However, a reduction of heart rate was more pronounced at the drug peripheral administration. The sensitivity to flesinoxan in the hypertensive rats was greater than in the normotensive rats.
Piianzin
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Popova
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Markel'
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D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*
D000959:Antihypertensive Agents; D010879:Piperazines; D011985:Receptors, Serotonin; C056895:flesinoxan
Vliianie agonista serotoninovykh retseptorov C1a podtipa flezinoksana na arterial'noe davlenie u krys.