title: The structural and functional heterogeneity of glutamic acid decarboxylase: a review.
abstract: Studies of the GABA-synthetic enzyme glutamate decarboxylase (glutamic acid decarboxylase; GAD; E.C.4.1.1.15) began in 1951 with the work of Roberts and his colleagues. Since then, many investigators have demonstrated the structural and functional heterogeneity of brain GAD. At least part of this heterogeneity derives from the existence of two GAD genes.
authors.affiliation: Neuroscience Program, University of California, Los Angeles 90024.
authors.forename: M G
authors.initials: MG
authors.lastname: Erlander
authors.forename: A J
authors.initials: AJ
authors.lastname: Tobin
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D005968:Glutamate Decarboxylase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000201:enzymology / Q000648:ultrastructure; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase