Interleukin-1 production from peripheral blood monocytes in septic infections in children.
Interleukin-1 (IL-1) production from peripheral blood mononuclear cells (MNC) was studied in 18 children with septic infection. IL-1 activity was measured from the supernatants of MNC cultures at various times after infection. At the acute stage of infection the IL-1 activity was low (depressed) but rose in early convalescent stage and was normalized at late control after infection. In prolonged infections lasting for 11-25 days the IL-1 activity showed further decline. Rising IL-1 production of MNC in septic infection may be regarded as a good prognostic sign, whereas a declining IL-1 activity may be suggestive of prolonged or complicated course of infection.
Helminen
M
M
Department of Paediatrics, Tampere University Hospital, Finland.
D000293:Adolescent; D001424:Bacterial Infections / Q000097:blood* / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000627:therapeutic use; D007902:Length of Stay; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D011379:Prognosis; D013997:Time Factors
D007375:Interleukin-1