title: Effects of single and repeated marijuana smoke exposure on fetal EEG.
abstract: The effect of single and repeated marijuana smoke exposure on fetal EEG was investigated in the chronic fetal lamb model using power spectral analysis. Maternal inhalation of marijuana smoke (n = 9) resulted in a significant reduction in total power and power distribution in the delta (1-4 Hz) band, and an increase in power distribution in the faster frequencies in the first h after smoke inhalation. These EEG changes were not observed following maternal inhalation of placebo smoke (n = 5), nor in animals with 3-5 prior exposures to marijuana smoke (n = 5). These results suggest that the effects of marijuana smoke exposure on fetal EEG is short-lived and tolerance develops rapidly with repeated exposure.
authors.affiliation: Department of Pharmacology, Cornell University Medical College, New York, NY 10021.
authors.forename: H H
authors.initials: HH
authors.lastname: Szeto
authors.forename: D L
authors.initials: DL
authors.lastname: Wu
authors.forename: J A
authors.initials: JA
authors.lastname: Decena
authors.forename: Y
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000818:Animals; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000502:physiology*; D008385:Marijuana Smoking / Q000503:physiopathology*; D011247:Pregnancy; D012756:Sheep