Effect of nifedipine on renal microvascular cholesterol accumulation and prostacyclin biosynthesis in cholesterol-fed rabbits.
Studies, performed in rabbits, examined the effect of feeding a high cholesterol diet and/or a calcium antagonist, nifedipine, on renal microvascular prostacyclin biosynthesis and cholesterol accumulation. After 30 days, cholesterol-fed rabbits had elevated serum and tissue cholesterol levels associated with decreased microvascular prostacyclin biosynthesis and histologic evidence of microvascular and glomerular lipid accumulation. Nifedipine reduced tissue cholesterol levels, enhanced prostacyclin biosynthesis, and reduced the histologic evidence for lipid accumulation in renal microvessels and glomeruli. These studies suggest that calcium antagonists may have a beneficial effect in preventing the tissue cholesterol accumulation associated with a high-cholesterol diet and further suggest that these agents may have beneficial effects in the treatment of renal diseases associated with microvascular or glomerular lipid accumulation.
Kirschenbaum
M A
MA
Nephrology Section, Department of Veterans Affairs Medical Center, Long Beach, CA 90822.
Roh
D D
DD
Kamanna
V S
VS
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D007668:Kidney / Q000098:blood supply*; D008833:Microcirculation / Q000378:metabolism; D009543:Nifedipine / Q000494:pharmacology*; D011817:Rabbits
D002788:Cholesterol Esters; D002791:Cholesterol, Dietary; D015121:6-Ketoprostaglandin F1 alpha; D002784:Cholesterol; D009543:Nifedipine