Protein metabolism after abdominal surgery: effect of 24-h extradural block with local anaesthetic.
We have studied the effect of intraoperative and postoperative (24 h) extradural block with local anaesthetic on whole body protein turnover (stable isotope methodology) and urinary excretion of urea nitrogen, adrenaline, noradrenaline and cortisol in a group of well nourished elderly patients undergoing colorectal surgery who received a constant nutritional intake before (7 days) and after (4 days) surgery. One group (control, n = 8) received routine anaesthetic and surgical care. Patients in the test group (extradural, n = 9) received extradural bupivacaine, and sensory block (T4-S5) was maintained during and after surgery for a period of 24 h. Whole body protein breakdown and amino acid oxidation increased significantly after surgery in both groups (P less than 0.05), but the increase in protein breakdown in the extradural group was significantly less than that in the control group. Urinary excretion of urea nitrogen, adrenaline and noradrenaline increased in the control group after surgery, whilst the increase in the extradural group was very small. In contrast, urinary excretion of cortisol increased significantly in both groups after surgery. We conclude that extradural block maintained for 24 h after surgery significantly minimized postoperative protein breakdown without compromising whole body protein synthesis.
Carli
F
F
Department of Anaesthesia, Northwick Park Hospital, Harrow, Middlesex.
Webster
J
J
Pearson
M
M
Pearson
J
J
Bartlett
S
S
Bannister
P
P
Halliday
D
D
D000005:Abdomen / Q000601:surgery*; D000368:Aged; D015360:Analgesia, Epidural; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D002045:Bupivacaine; D002395:Catecholamines / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D007930:Leucine / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D011184:Postoperative Period; D011506:Proteins / Q000378:metabolism*; D014508:Urea / Q000652:urine
D002395:Catecholamines; D011506:Proteins; D014508:Urea; D003404:Creatinine; D007930:Leucine; D006854:Hydrocortisone; D002045:Bupivacaine