[The effect of cow's milk and its hydrolysates on the metabolism of 17-hydroxycorticosteroids and the functional state of the gastrointestinal tract in guinea pigs].
Two groups of noninbred male guinea pigs (initial bw 250-300 g) received test rations in which 50% of standard ration protein were substituted for milk protein (P 20/80) and its enzymatic hydrolysate (H 20/80). The influence of P 20/80 and H 20/80 on some parameters of the gastro-intestinal tract (GIT) barrier function and 17-OCS metabolism was studied. The action of H 20/80 as compared to P 20/80 was expressed in the intensified excretion of free fraction of 17-OCS and glucuronides. The content of hydroxylated glucocorticoids increased in both fractions. At the same time elevated total proteolytic activity in the gastric mucosa and a tendency to decreased GIT permeability for chicken ovalbumin macromolecules were observed in animals that received H 20/80. It has been suggested that enzymatic hydrolysates of food proteins influence endocrine regulation of metabolic processes.
Malikova
N A
NA
Marokko
I N
IN
Samenkova
N F
NF
Gmoshinskiĭ
I V
IV
Mazo
V K
VK
D015065:17-Hydroxycorticosteroids / Q000378:metabolism*; D000818:Animals; D004064:Digestive System / Q000187:drug effects / Q000378:metabolism; D004068:Digestive System Physiological Phenomena; D006168:Guinea Pigs; D008297:Male; D008894:Milk Proteins / Q000494:pharmacology*; D011492:Protein Hydrolysates / Q000494:pharmacology*
D015065:17-Hydroxycorticosteroids; D008894:Milk Proteins; D011492:Protein Hydrolysates
Vliianie belkov korov'ego moloka i ikh gidrolizatov na metabolizm 17-oksikortikosteroidov i funktsional'noe sostoianie zheludochno-kishechnogo trakta u morskikh svinok.