Central pharmacological effects of long-term application of piracetam in rats.
Effect of the 14-day administration of piracetam in a dose of 5 g/kg ip upon the behavior of rats and on the content of biogenic amines and their metabolites in different brain areas was studied. It was shown that the treatment by PI for 14 days produced changes in the rat behavior manifested mainly by inhibition of exploratory activity. Long-term PI administration modified the content of NA, DA and 5-HT and their metabolites in different parts of the brain.
Felińska
W
W
Department of Pharmacology, Silesian Academy of Medicine, Zabrze, Poland.
Bień
E
E
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D001679:Biogenic Amines / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D003672:Defecation / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010889:Piracetam / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D001679:Biogenic Amines; D001058:Apomorphine; D010889:Piracetam