[A comparative evaluation of the anti-ischemic action of verapamil in different models of myocardial ischemia].
The effectiveness of the anti-ischemic effect of verapamil was studied on models of coronary spasm (the test with dihydroergotamine) and microthrombosis of the coronary arteries (the test with ADP). The results of the performed studies showed that verapamil exerts the anti-ischemic effect at administration of dihydroergotamine and ADP. The most pronounced effect of verapamil was demonstrated on the model of myocardial ischemia due to coronary spasm.
Gurbanov
K K
KK
Kovalev
G V
GV
Paperno
A A
AA
D000244:Adenosine Diphosphate; D000818:Animals; D002415:Cats; D003327:Coronary Disease / Q000139:chemically induced / Q000188:drug therapy*; D003328:Coronary Thrombosis / Q000139:chemically induced / Q000188:drug therapy; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000188:drug therapy; D004087:Dihydroergotamine; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography / Q000187:drug effects; D014700:Verapamil / Q000627:therapeutic use*
D004087:Dihydroergotamine; D000244:Adenosine Diphosphate; D014700:Verapamil
Sravnitel'naia otsenka antiishemicheskogo deĭstviia verapamila na razlichnykh modeliakh ishemii miokarda.