title: Subacute inhalation toxicity of benzaldehyde in the Sprague-Dawley rat.
abstract: Benzaldehyde was administered by inhalation to female and male Sprague-Dawley rats for 14 consecutive days (low level: 500 ppm; medium level: 750 ppm; high level: 1000 ppm). Effects of this chemical were investigated during and at the end of the exposure period. Throughout the experiment, significant hypothermia and a reduction of motor activity were observed in all rats exposed to benzaldehyde and were accompanied in high-level rats by a severe impairment of the central nervous system, as evidenced by abnormal gait, tremors, and a positive Straub sign. Histopathologic examination of tissues from exposed rats showed a goblet cell metaplasia that was largely confined to the respiratory epithelium lining the nasal septum in male rats. No other abnormal microscopic changes were observed. A no effect level was not observed in these studies.
authors.affiliation: Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario.
authors.forename: S
authors.initials: S
authors.lastname: Laham
authors.forename: B
authors.initials: B
authors.lastname: Broxup
authors.forename: M
authors.initials: M
authors.lastname: Robinet
authors.forename: M
authors.initials: M
authors.lastname: Potvin
authors.forename: K
authors.initials: K
authors.lastname: Schrader
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001547:Benzaldehydes / Q000008:administration & dosage / Q000633:toxicity*; D002493:Central Nervous System Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D005260:Female; D007035:Hypothermia / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009296:Nasal Cavity / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001547:Benzaldehydes; C032175:benzaldehyde