The effect of lipo-prostaglandin E1 on the production of interleukin 1 and platelet-activating factor by hepatic sinusoidal endothelial cells in mice.
We first studied the production of interleukin 1 (IL1) and platelet-activating factor (PAF) by mouse hepatic sinusoidal endothelial cells and then the effect of Lipo-prostaglandin E1 (Lipo-PGE1) on IL1 and PAF production by these cells. The incubation of mouse hepatic sinusoidal endothelial cells with lipopolysaccharide (LPS) or calcium-ionophore (CaI) A23187 resulted in a concentration-dependent production of IL1 and PAF. However, Lipo-PGE1 dose-dependently decreased the LPS- or CaI A23187-induced production of IL1 and PAF. These results suggested that Lipo-PGE1 acts on hepatic sinusoidal endothelial cells to decrease the production of IL1 and PAF, thereby ameliorating inflammatory reactions in the liver.
Mizoguchi
Y
Y
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Ichikawa
Y
Y
Kawada
N
N
Kobayashi
K
K
Morisawa
S
S
D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D004727:Endothelium / Q000166:cytology / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism*; D008099:Liver / Q000166:cytology* / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010972:Platelet Activating Factor / Q000378:metabolism*
D007375:Interleukin-1; D010972:Platelet Activating Factor; D000527:Alprostadil