Alprazolam enhances the antibacterial activity exerted by normal human peripheral blood lymphocytes.
The effects of two benzodiazepines, diazepam and alprazolam, have been evaluated on the in vitro antibacterial activity exerted by human peripheral blood lymphocytes (PBL). Results demonstrate that diazepam has no influence on this PBL function, while alprazolam is able to enhance this activity in six out of nine normal donors considered. The possible therapeutical implications of these data are discussed.
Covelli
V
V
Clinica Neurologica, II Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.
Maffione
A B
AB
Cannuscio
B
B
Jirillo
E
E
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000328:Adult; D000525:Alprazolam / Q000494:pharmacology*; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D003601:Cytotoxicity Tests, Immunologic; D003975:Diazepam / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D012485:Salmonella typhi; D013268:Stimulation, Chemical; D016176:T-Lymphocyte Subsets / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D003975:Diazepam; D000525:Alprazolam