Prefrontal cortex self-stimulation and energy balance.
The relation between sulcal prefrontal cortex (SPC) and medial prefrontal cortex (MPC) self-stimulation and energy balance was investigated in rats. SPC but not MPC self-stimulation induced feeding but not the gnawing of wooden blocks. SPC but not MPC self-stimulation enhanced weight gain over several weeks of exposure to stimulation. Food deprivation (48 hr but not 24 hr) increased SPC self-stimulation rates under a 5-s fixed-interval reinforcement schedule and decreased current thresholds for SPC self-stimulation. MPC self-stimulation was unaffected by food deprivation. Insulin (4 U/kg) and 2-deoxy-D-glucose (300 mg/kg) inhibited both SPC and MPC self-stimulation, probably through interfering with performance. Satiety induced by prolonged intake of a sweetened solution or deprivation-induced feeding moderately facilitated SPC self-stimulation. Overall, it appears that SPC but not MPC self-stimulation modulates, and is modulated by, energy balance.
McGregor
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Department of Psychology, University of Sydney, New South Wales, Australia.
Atrens
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D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001931:Brain Mapping; D003847:Deoxyglucose / Q000378:metabolism; D004326:Drinking / Q000502:physiology; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005508:Food Deprivation / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology*; D007026:Hypothalamic Area, Lateral / Q000502:physiology; D007328:Insulin / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012528:Satiety Response / Q000502:physiology; D012653:Self Stimulation / Q000502:physiology*
D007328:Insulin; D003847:Deoxyglucose