Bioactive polymers 66. Theophylline retardation in xanthan-based hydrogels.
Xanthan has been reticulated with epichlorohydrin to obtain a hydrogel for use in drug retardation. The obtained gel shows swelling degrees up to 1000. Theophylline has been inserted by diffusion into this gel; concentrations around 150 mg theophylline/g dry hydrogel being obtained. Controlled release of theophylline has been established by elution in a close recirculation system. Zero-order kinetics has been obtained in the diffusion process of theophylline into the eluent, within a 14 h time interval.
Dumitriu
S
S
Polytechnic Institute of Jassy, Romania.
Dumitriu
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M
D004337:Drug Carriers; D016503:Drug Delivery Systems; D005782:Gels; D007700:Kinetics; D011135:Polysaccharides, Bacterial; D013806:Theophylline / Q000008:administration & dosage*
D004337:Drug Carriers; D005782:Gels; D011135:Polysaccharides, Bacterial; D013806:Theophylline; C002563:xanthan gum