[The effect of microsomal enzyme inducers on the renal transport of iodamide].
On the 3rd day after the last administration of phenobarbital (50 mg/kg orally, 4 days), benzonal (35 mg/kg orally, 4 days), zixorine (200 mg/kg orally, 4 days) and 3-methylcholanthrene (20 mg/kg subcutaneously, 2 days) the rats exhibited a decrease of iodamide secretion in the kidneys. The administration of zixorine to the dog (200 mg orally, 6 days) led to a significant decrease of iodamide transport in the first two weeks after discontinuation of the drug administration.
Ul'ianov
G P
GP
Lampatov
V V
VV
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003864:Depression, Chemical; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D007451:Iodamide / Q000493:pharmacokinetics*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008861:Microsomes / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013997:Time Factors
D007451:Iodamide
Vliianie induktorov mikrosomal'nykh fermentov na pochechnyĭ transport ĭodamida.