Fluoroacetate and fluorocitrate: mechanism of action.
The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a "suicide" substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glial-neuronal relationships is considered.
Clarke
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DD
Department of Chemistry, Fordham University, Bronx, NY 10458.
D000154:Aconitate Hydratase / Q000378:metabolism*; D000818:Animals; D002951:Citrates / Q000633:toxicity*; D005463:Fluoroacetates / Q000378:metabolism*; D009457:Neuroglia / Q000187:drug effects; D009474:Neurons / Q000187:drug effects
D002951:Citrates; D005463:Fluoroacetates; C007744:fluorocitrate; D000154:Aconitate Hydratase