title: Systemic lupus erythematosus.
abstract: Systemic lupus erythematosus is a prototypic autoimmune disease characterized by antinuclear antibody production. In recent investigations, the contributions of various polymorphic immune response gene systems to disease pathogenesis have been analyzed. Unique cellular and molecular studies have also established the role of 'autoantigen drive' in autoantibody induction and its relationship to polyclonal B-cell activation.
authors.affiliation: Durham VA Hospital, North Carolina.
authors.forename: D S
authors.initials: DS
authors.lastname: Pisetsky
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology; D051379:Mice
chemical_list: D000974:Antibodies, Antinuclear; D001324:Autoantigens