Effects of 3-aminobenzamide on the post-initiation phase of N-nitrosobis(2-oxopropyl)amine induced pancreatic carcinogenesis in Syrian hamsters.
Effects of 3-aminobenzamide (ABA) on pancreatic carcinogenesis after initiation by N-nitrosobis(2-oxopropyl)amine (BOP) were investigated in Syrian hamsters. Animals were given BOP at a dose of 70 mg/kg body weight by subcutaneous injection and following a 2-week recovery period, were administered basal diet or basal diet containing 0.5, 0.75 and 1.5% ABA for 30 weeks. While the incidences of resultant pancreatic lesions, including hyperplasia, atypical hyperplasia and carcinoma, induced by BOP were not significantly influenced by ABA treatment, the mean numbers of those pancreatic lesions were significantly decreased in a dose-dependent way. The results therefore suggested the possible involvement of poly(ADP-ribosyl)ation in the post-initiation phase of pancreatic carcinogenesis in hamsters.
Tsujiuchi
T
T
Department of Oncological Pathology, Cancer Center, Nara Medical College, Japan.
Mizumoto
K
K
Tsutsumi
M
M
Denda
A
A
Amanuma
T
T
Kondoh
S
S
Konishi
Y
Y
D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines; D009929:Organ Size / Q000187:drug effects; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
D001549:Benzamides; D002273:Carcinogens; D009602:Nitrosamines; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011838:Radiation-Sensitizing Agents; C013622:nitrosobis(2-oxopropyl)amine; C025160:3-aminobenzamide