title: Villous tumors of the duodenum. Presentation of five cases.
abstract: Five cases of villous tumors of the duodenum are reported. These tumors have a predilection for the periampullary region and tend to present with jaundice or obstruction of the duodenal lumen. In four of these patients, malignant transformation was seen. Endoscopy and biopsy play a major rôle in attempting to obtain an accurate preoperative diagnosis. Unfortunately, the diagnosis of malignant degeneration is frequently missed, even when multiple biopsies are taken. For this reason villous tumors should always be resected, and the strategy of treatment must depend on pre-, intra- and postoperative histological evaluation, location in the duodenum and intra-operative findings.
authors.affiliation: Dept. of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands.
authors.forename: B J
authors.initials: BJ
authors.lastname: Witteman
authors.forename: A R
authors.initials: AR
authors.lastname: Janssens
authors.forename: J L
authors.initials: JL
authors.lastname: Terpstra
authors.forename: F
authors.initials: F
authors.lastname: Eulderink
authors.forename: K
authors.initials: K
authors.lastname: Welvaart
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology; D000368:Aged; D014670:Ampulla of Vater; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000453:epidemiology; D003138:Common Bile Duct Neoplasms / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged