title: [The light sensitivity of corticosteroids in crystalline form. Photochemical studies. 59. (1)].
abstract: The light sensitivity of corticosteroids in the solid state have been investigated and the photodecomposition rates of the compounds have been estimated by HPLC. After 48 h UV-irradiation desoxycortone acetate, hydrocortisone, hydrocortisone acetate, prednisolone, methylprednisolone, dexamethasone, betamethasone and triamcinolone acetonide decompose between 20 and 50%. Cortisone acetate, prednisone and fluocinolone acetonide show photostability in contrast to requirements of the Pharmacopeia for light protections.
authors.affiliation: Institut für Pharmazeutische Chemie, Semmelweis Medizinischen Universität.
authors.forename: M
authors.initials: M
authors.lastname: Takács
authors.forename: N
authors.initials: N
authors.lastname: Ekiz-Gücer
authors.forename: J
authors.initials: J
authors.lastname: Reisch
authors.forename: A
authors.initials: A
authors.lastname: Gergely-Zobin
mesh_terms: D000305:Adrenal Cortex Hormones / Q000737:chemistry / Q000528:radiation effects*; D002851:Chromatography, High Pressure Liquid; D008027:Light; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000305:Adrenal Cortex Hormones
vernacular_title: Lichtempfindlichkeit von Corticosteroiden in kristallinem Zustand. Photochemische Studien, 59. Mitt. [1].