Use of nonimaging nuclear medicine techniques to assess the effect of flunixin meglumine on effective renal plasma flow and effective renal blood flow in healthy horses.
The effect of flunixin meglumine on renal function was studied in 6 healthy horses by use of nonimaging nuclear medicine techniques. Effective renal plasma flow (ERPF) and effective renal blood flow (ERBF) were determined by plasma clearance of 131I-orthoiodohippuric acid before and after administration of flunixin meglumine. Mean ERPF and ERBF was 6.03 ml/min/kg and 10.7 ml/min/kg, respectively, before treatment and was 5.7 ml/min/kg and 9.7 ml/min/kg, respectively, after treatment. Although ERPF and ERBF decreased after flunixin meglumine administration, the difference was not statistically significant.
Held
J P
JP
Department of Rural Practice, College of Vetertinary Medicine, University of Tennessee, Knoxville 37901-1071.
Daniel
G B
GB
D000818:Animals; D003002:Clonixin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006736:Horses / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D009683:Nuclear Medicine / Q000379:methods; D012044:Regression Analysis; D012079:Renal Circulation / Q000187:drug effects*
C014558:flunixin meglumine; D003002:Clonixin