title: [Malaria in the republic of São Tomé and Principe. Epidemiologic evaluation and chemoresistance of P. falciparum].
abstract: The authors report the results of a valuation of paludometric indices during mai 1990 in Democratic São Tomé e Príncipe Republic (RDSTP). These investigations (parasitic index and spleen index) suggest that malaria is mesoendemic in these area. Plasmodium susceptibility to chloroquine at posology of 25 mg/kg per os was evaluated (WHO standard 7 days field test). Among 58 children, ranging from 5 to 11 years old, resistance at level R I was observed in 9% of cases, at level R II in 14%. Among 10 strains of P. falciparum, 9 were chloroquine resistant in vitro. 2 strains were also less sensible to quinine.
authors.affiliation: Hôpital d'instruction des Armées A. Laveran, Service de Biologie clinique, Marseille.
authors.forename: G
authors.initials: G
authors.lastname: Martet
authors.forename: S
authors.initials: S
authors.lastname: Da Conceicao
authors.forename: G
authors.initials: G
authors.lastname: Cordoliani
authors.forename: H
authors.initials: H
authors.lastname: Delolme
authors.forename: G
authors.initials: G
authors.lastname: Raphenon
authors.forename: P
authors.initials: P
authors.lastname: Hovette
authors.forename: J C
authors.initials: JC
authors.lastname: Doury
authors.forename: D
authors.initials: D
authors.lastname: Baudon
authors.forename: J E
authors.initials: JE
authors.lastname: Touze
authors.forename: J L
authors.initials: JL
authors.lastname: Lecamus
mesh_terms: D000367:Age Factors; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D001266:Atlantic Islands / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000453:epidemiology*; D008297:Male; D015767:Mefloquine / Q000494:pharmacology; D010616:Phenanthrenes / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000494:pharmacology; D012621:Seasons; D012737:Sex Factors; D013163:Splenomegaly
chemical_list: D000962:Antimalarials; D010616:Phenanthrenes; D002738:Chloroquine; D011803:Quinine; C023768:halofantrine; D015767:Mefloquine
vernacular_title: Le paludisme en république de São Tomé et Principe. Evaluation épidémiologique et chimiorésistance de P. falciparum.