[The effect of an insulin load on rat mast cells].
The increase of heparin secretion by mast cells of kidney capsule and subcutaneous fat has been noted in rats after 30 min intravenous insulin administration in a dose 0.3 U/200 g (by this time the blood sugar concentration lowers by 40%). The index of mast cells saturation with heparin drops by 2.3 and 1.9 times correspondingly. After preliminary administration of protamine sulphate (2 mg/200 g that provokes in rats the status of temporary resistance to the hypoglycemic action of insulin the stimulatory effect of insulin on the function of mast cells does not occur.
Shapiro
F B
FB
Umarova
B A
BA
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D006493:Heparin / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D008643:Mesentery / Q000187:drug effects / Q000378:metabolism; D011479:Protamines / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D007328:Insulin; D011479:Protamines; D006493:Heparin
Vliianie insulinovoĭ nagruzki na tuchnye kletki krys.