title: [Diabetes insipidus and Langerhans-cell histiocytosis without changes in cerebral CAT and NMR].
abstract: In LCH extended disease CNS involvement in is not infrequent. Diabetes insipidus, due to the affectation of hypothalamus-hypophysis axis, is its most frequent finding. The solitary affectation of hypothalamus-hypophysis axis is exceptional. At times, it's a difficult diagnosis and could precede the diagnosis of LCH several years. Usually, CAT and NMR show morphologic lesions. We report a patient who was diagnosed of idiopathic diabetes insipidus when he was 16 years old. Seven year later, he was diagnosed of LCH after underwent a bone marrow biopsy examination, just when the disease involved the bone and lung. Cerebral CAT and NMR didn't show morphologic lesions. In the presence of morphologic lesions in hypothalamus and/or hypophysis, proved by cerebral CAT and NMR, or a clinical setting of DI, the possibility of LCH must be considered.
authors.affiliation: Servicio de Neumología, Hospital La Paz, Universidad Autónoma, Madrid.
authors.forename: J
authors.initials: J
authors.lastname: Muñoz Méndez
authors.forename: B
authors.initials: B
authors.lastname: Ortega Cuesta
authors.forename: B
authors.initials: B
authors.lastname: García Rubio
authors.forename: A
authors.initials: A
authors.lastname: de Ramón Casado
authors.forename: M
authors.initials: M
authors.lastname: Vázquez Mezquita
authors.forename: J
authors.initials: J
authors.lastname: Fernández Francés
authors.forename: J M
authors.initials: JM
authors.lastname: González Ruiz
authors.forename: S
authors.initials: S
authors.lastname: Díaz Lobato
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D001856:Bone Marrow Examination; D001842:Bone and Bones / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging*; D003919:Diabetes Insipidus / Q000209:etiology*; D003937:Diagnosis, Differential; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed
vernacular_title: Diabetes insípida en histiocitosis de células de Langerhans, sin alteraciones en la TAC y RMN cerebral.