Effect of lignocaine on blood lipid in relation to partition coefficient and biological activity.
To correlate lipophilicity of lignocaine with changes in lipid composition of blood as a result of in vitro incubation with the drug, phosphorus content and fatty acid compositions of blood lipids before and after lignocaine treatment have been compared with those of a standard phospholipid, lecithin, under similar conditions of drug treatment. The change in fatty acid constituents has been correlated with the biological activity (both therapeutic and toxic) of lignocaine.
Dutta
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Department of Pharmaceutical Technology, Jadavpur University, Calcutta.
Sengupta
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Ghosh
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A
Sengupta
C
C
De
A U
AU
D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D005227:Fatty Acids / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006041:Goats; D008012:Lidocaine / Q000494:pharmacology*; D008055:Lipids / Q000097:blood* / Q000302:isolation & purification; D010743:Phospholipids / Q000097:blood
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D010743:Phospholipids; D008012:Lidocaine