title: [Effect of L-carnitine supplementation on lipid metabolism of renal failure, dialysis-dependent children and adolescents].
abstract: In six renally insufficient children and adolescents (age: 8-21 years) on hemodialysis the effect of L-carnitine supplementation at two dose levels (10 mg/kg/d vs. 100 mg/kg/d) on parameters of lipid metabolism was investigated. L-Carnitine substitution was carried out over four weeks per dose level. Under this regime a significant increase of the serum carnitine concentration occurred together with a decrease in the AC/FC-ratio (x: 1.59 to x:0.83). During the same period a significant decrease in serum triglyceride levels as well as an increase in serum HDL-cholesterol were observed. An inverse correlation (r = -0.63; p less than 0.0008) was found between HDL-cholesterol and the AC/FC-ratio. L-carnitine supplementation and its increasing effect on HDL-cholesterol in patients with renal insufficiency may be considered as antiatherogenic.
authors.affiliation: Zentrum der Kinderheikunde; Johann Wolfgang Goethe-Universität, Frankfurt/Main.
authors.forename: H
authors.initials: H
authors.lastname: Böhles
authors.forename: D
authors.initials: D
authors.lastname: Michalk
authors.forename: E
authors.initials: E
authors.lastname: von Wendt-Göknur
mesh_terms: D000293:Adolescent; D002331:Carnitine / Q000008:administration & dosage*; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D002331:Carnitine
vernacular_title: Der Einfluss einer L-Carnitin-Supplementierung auf den Lipidstoffwechsel niereninsuffizienter, dialysepflichtiger Kinder und Jugendlicher.