title: [Liver transplantation and the major histocompatibility complex].
abstract: We have carried out a retrospective study over 308 liver transplant patients (31 of them have had a retransplantation) in Professor Bismuth's Department at Paul Brousse Hospital. The purpose of the study was a search for the possible effect of donor/recipient major histocompatibility complex on the evolution of the transplantation. We chose to study four parameters: early acute rejection; chronic rejection; retransplantation cases and death frequency; graft survival. We observed the following: for HLA A locus: in cases of total or partial compatibility there are more moderate early acute rejections than in the case of incompatibility (p less than 0.02); for HLA B locus: in the case of total compatibility there are more chronic rejections than in cases of partial or total incompatibility (p less than 0.03); for joint A and B locus: the results are similar to those of A locus (p less than 0.03); for HLA class I: we observed no effect either on graft survival or on retransplantation cases or on death frequency; for HLA DR: we did not find any effect on the studied parameters. Considering the low statistical significance of these results and in order to confirm our analysis, we have started a prospective study in collaboration with two other European Transplantation Centers.
authors.affiliation: Poste de Transfusion, Hôpital Paul Brousse, Villejuif.
authors.forename: A
authors.initials: A
authors.lastname: Bismuth
authors.forename: B
authors.initials: B
authors.lastname: Ducot
authors.forename: D
authors.initials: D
authors.lastname: Samuel
authors.forename: J L
authors.initials: JL
authors.lastname: Arulnaden
authors.forename: J
authors.initials: J
authors.lastname: Gugenheim
authors.forename: P
authors.initials: P
authors.lastname: Debat
authors.forename: D
authors.initials: D
authors.lastname: Azoulay
authors.forename: P
authors.initials: P
authors.lastname: Farrokhi
authors.forename: C
authors.initials: C
authors.lastname: Pillier-Loriette
authors.forename: G
authors.initials: G
authors.lastname: Bourdon
mesh_terms: D006084:Graft Rejection; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D016031:Liver Transplantation / Q000276:immunology*; D008285:Major Histocompatibility Complex; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D006680:HLA Antigens
vernacular_title: Transplantation hépatique et complexe majeur d'histocompatibilité.