Serum chemistry alterations, including creatine kinase isoenzymes, in furazolidone toxicosis of ducklings: preliminary findings.
Furazolidone induces a cardiotoxicosis when fed in toxic concentrations to newly hatched ducklings. This preliminary experiment was designed to determine if creatine kinase (CK) isoenzymic activities or other serum analytes would be useful as indicators of these cardiac alterations. Sera from 12 ducklings (six fed a control ration and six fed the control ration with 700 mg furazolidone added per kg of feed [700 ppm] for 28 days) were analyzed for CK isoenzymic activities, electrolytes, nitrogenous metabolites, hepatic enzymic activities, bilirubin, and glucose. Statistically significant differences between control and treated groups were detected for creatine kinase MB (CK-MB, cardiac muscle origin) isoenzymic activity and bilirubin, potassium, calcium, and total carbon dioxide concentrations. Differences other than CK-MB isoenzymic activity were generally explained by factors related to the toxicosis or sample handling. These findings suggest that CK-MB isoenzymic activity may be useful to detect and monitor the progress of cardiac injury in furazolidone toxicosis, thereby increasing the usefulness of this model of dilated cardiomyopathy. Our findings, analyzed on the Kodak Ektachem 700 Dry Chemistry Analyzer, are compared with serum chemistry values reported in the literature.
Webb
D M
DM
Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907.
DeNicola
D B
DB
Van Vleet
J F
JF
D000136:Acid-Base Equilibrium; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001774:Blood Chemical Analysis / Q000662:veterinary; D001798:Blood Proteins / Q000032:analysis; D003402:Creatine Kinase / Q000097:blood*; D004372:Ducks; D004573:Electrolytes / Q000097:blood; D004587:Electrophoresis, Agar Gel; D005664:Furazolidone / Q000506:poisoning*; D006321:Heart / Q000187:drug effects*; D007527:Isoenzymes; D008297:Male; D011041:Poisoning / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D011201:Poultry Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D014527:Uric Acid / Q000097:blood
D001798:Blood Proteins; D004573:Electrolytes; D007527:Isoenzymes; D014527:Uric Acid; D005664:Furazolidone; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D001663:Bilirubin