The molecular basis of positional information.
Embryologists have dreamed of their own particular philosophers stone for 100 years. During that time they have repeatedly demonstrated the likely existence of signalling molecules or morphogens that control the pattern of development in the embryo. Now at last seems possible that some of these morphogens may have been identified. We review current evidence for the molecular basis of positional information.
Summerbell
D
D
Limb Development Group, National Institute for Medical Research, Mill Hill, London.
Smith
J C
JC
Maden
M
M
D000818:Animals; D002454:Cell Differentiation; D002642:Chick Embryo / Q000196:embryology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006829:Hydra / Q000196:embryology*; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014981:Xenopus / Q000196:embryology*