title: [Synthesis of CNS-activity of pyran derivatives: 6,8-dioxabicyclo(3,2,1)octane].
abstract: The amino nitriles 4a,b and 5a,b, prepared from (1S,5R)-6,8-dioxabicyclo[3,2,1]octan-4-one (2), react with phenylmagnesium bromide to afford the diastereomeric 4-amino-4-phenyl derivatives 7a,b and 8a,b, respectively. The diastereomeric piperidine derivatives 7b and 8b show different CNS-activity.
authors.affiliation: Institut für Pharmazie, Lebensmittelchemie der Universität München.
authors.forename: F
authors.initials: F
authors.lastname: Eiden
authors.forename: F
authors.initials: F
authors.lastname: Denk
mesh_terms: D000374:Aggression / Q000187:drug effects; D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds; D002490:Central Nervous System / Q000187:drug effects*; D051379:Mice; D010880:Piperidines; D013237:Stereoisomerism
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D001643:Bridged Bicyclo Compounds; D010880:Piperidines
vernacular_title: Synthese und ZNS-Wirkung von Pyranderivaten: 6,8-Dioxabicyclo[3,2,1]octane.