Ocular and cardiovascular pharmacology of tetramethylpyrazine isolated from Ligusticum wallichii Franch.
Tetramethylpyrazine (TMP), the active principle in Ligusticum wallichii, D-timolol, and L-timolol were compared for their effects on retinal and choroidal blood flow (RCBF), blood pressure (BP), and heart rate (HR). TMP (10 mg.kg-1) increased RCBF by 44% and did not affect systemic BP or HR. D-Timolol (4 mg.kg-1 iv) had a tendency to increase RCBF but did not affect systemic BP and HR either. L-Timolol (0.4 mg.kg-1 iv), on the other hand, decreased RCBF by 18% and reduced both systemic BP and HR. In isolated preparations, TMP increased coronary artery blood flow with slight vasodilation, but vasoconstriction in renal, femoral and mesenteric arteries. These results indicate that TMP could be used to prevent or alleviate certain ischemic retinal degenerations without producing significant cardiovascular side effects. The in vitro vasoconstriction actions of TMP (0.2 mg.ml-1) were blocked by propranolol and phenoxybenzamine, indicating that adrenergic mechanism might be involved in TMP action.
Chiou
G C
GC
Department of Medical Pharmacology & Toxicology, Texas A&M University College of Medicine, College Station 77843.
Yan
H Y
HY
Lei
X L
XL
Li
B H
BH
Shen
Z F
ZF
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002829:Choroid / Q000098:blood supply; D003326:Coronary Circulation / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D011719:Pyrazines / Q000494:pharmacology*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D012171:Retinal Vessels / Q000187:drug effects* / Q000502:physiology; D013237:Stereoisomerism; D013999:Timolol / Q000494:pharmacology; D014665:Vasodilator Agents
D011719:Pyrazines; D014665:Vasodilator Agents; D013999:Timolol; C017953:tetramethylpyrazine