[An analysis of the possible mechanism of the ulcerostatic action of 1-ethoxysilatrane].
Stimulating effect of 1-ethoxysilatrane on healing processes of experimental stomach ulcers was studied in rats. 1-ethoxysilatrane inhibited lipid peroxidation in blood and stomach wall tissues, interacted with artificial membranes, and affected the rate of mitochondrial respiration in liver. A hypothesis is put forward on the membranotropic effect of 1-ethoxysilatrane which underlies its ulcerostatic effect.
Rasulov
M M
MM
Kuznetsov
I G
IG
Bartkova
L K
LK
Suslova
S K
SK
Belousov
A A
AA
Voronkov
M G
MG
D000085:Acetates; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004353:Drug Evaluation, Preclinical; D008051:Lipid Bilayers; D015227:Lipid Peroxidation / Q000187:drug effects; D008563:Membrane Lipids; D008564:Membrane Potentials / Q000187:drug effects; D017646:Organosilicon Compounds; D051381:Rats; D012825:Silicon / Q000494:pharmacology / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D000085:Acetates; D000897:Anti-Ulcer Agents; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D008051:Lipid Bilayers; D008563:Membrane Lipids; D017646:Organosilicon Compounds; C042292:1-ethoxysilatrane; D012825:Silicon
Analiz vozmozhnogo mekhanizma ul'tserostaticheskogo deĭstviia 1-étoksisilatrana.