Effect of reserpine and calcium antagonists on doxorubicin storage in various organs of young and senescent rats.
Reserpine pre-treatment causes a considerable decrease in typical red-orange doxorubicin fluorescence of the organs examined (kidney, large intestine, spleen) and a similar picture is observed after calcium antagonists administration. This effect is far more evident in the spleen and large intestine than in the kidney; moreover, it seems more marked in young rats compared with aged ones. An inhibitory action of these drugs on the anthracycline transport carrier through the cell membrane is hypothesized.
Pellegrini
A
A
Istituto di Anatomia Umana Normale, Facoltà di Medicina e Chirurgia, Università degli Studi di Pisa, Italia.
Soldani
P
P
Breschi
M C
MC
Paparelli
A
A
D000375:Aging; D000818:Animals; D004317:Doxorubicin / Q000493:pharmacokinetics*; D007420:Intestine, Large / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D008856:Microscopy, Fluorescence; D024510:Muscle Development; D009130:Muscle, Smooth / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D009529:Nicardipine / Q000494:pharmacology*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D014700:Verapamil / Q000494:pharmacology*
D004317:Doxorubicin; D012110:Reserpine; D014700:Verapamil; D009529:Nicardipine