[Study of viral replication in HbsAg positive chronic hepatitis].
Viral replication seric markers (VRSM), (BeHAg, BcHAg, and DNA-VHB) and the hepatic tissue BcHAg of thirty four patients suffering from chronic hepatopathies (6 PCH, 18 ACH, and 10 cirrhosis) were investigated. The greatest incidence of RVSM was observed in PCH. The combined study using all the markers demonstrated a positive correlation: DNA-VHB and BeHAg (p less than 0,001); DNA-VHB and BcHAg (p less than 0,001); BeHAg and BcHAg (p less than 0,001). The same result was obtained when comparing BcHAg (n) with the rest of RVSM: DNA-VHB (p less than 0,001), BeHAg (p less than 0,001) and seric BcHAg (p less than 0,01). Patients with a most intense histologic activity according to the Knodell index, presented a higher ratio of positive nuclei for BcHAg. The conclusion is that there is a good correlation amongst replication markers, specially hepatic BcHAg and DNA-VHB.
Tomás Gilabert
J
J
Servicio de Microbiología, Hospital Universitario de Granada.
Galán Navarro
M I
MI
Caballero Morales
T
T
Maroto Vela
M C
MC
Ruiz Extremera
A
A
Salmerón Escobar
F J
FJ
D015415:Biomarkers; D002908:Chronic Disease; D006511:Hepatitis B Antigens / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000502:physiology*; D006801:Humans; D008107:Liver Diseases / Q000276:immunology / Q000382:microbiology*; D014779:Virus Replication / Q000276:immunology*
D015415:Biomarkers; D006511:Hepatitis B Antigens; D006514:Hepatitis B Surface Antigens
Estudio de la replicaciíon vírica en las hepatitis crónicas AgHBs positivo.