title: Oral prostaglandin E1 derivative (OP-1206) in an infant with double outlet right ventricle and pulmonary stenosis. Effect on ductus-dependent pulmonary circulation.
abstract: A small-for-gestational-age infant with cyanosis due to double outlet right ventricle with severe pulmonary stenosis and patent ductus arteriosus was treated with oral prostaglandin E1 derivative (OP-1206). The constricting ductus arteriosus dilated and the ductus-dependent pulmonary blood flow increased. The recommended dosage was 1.5-2.0 micrograms/kg/day which was lower than that of intravenous PGE1 or of oral PGE2. The administration interval was 6 hours, which was longer than that of oral PGE2. The patient was treated as an out-patient because continuous intravenous infusion was not necessary. Treatment was continued for 2 months without complication, at which time a Blalock-Taussig shunt operation was performed. Orally administered PGE1 derivative (OP-1206) was found to be equally effective to intravenous infusion of PGE1 for both short and long-term management of cyanotic heart disease in which the pulmonary blood flow is mostly dependent on the patency of the ductus arteriosus. Oral PGE1 derivative (OP-1206) may be a possible substitute for intravenous PGE1 infusion therapy.
authors.affiliation: Department of Pediatrics, Toho University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Saji
authors.forename: H
authors.initials: H
authors.lastname: Matsuura
authors.forename: K
authors.initials: K
authors.lastname: Hoshino
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Ishikita
authors.forename: N
authors.initials: N
authors.lastname: Matsuo
mesh_terms: D000284:Administration, Oral; D000527:Alprostadil / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004310:Double Outlet Right Ventricle / Q000150:complications*; D004374:Ductus Arteriosus, Patent / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011652:Pulmonary Circulation / Q000187:drug effects*; D011666:Pulmonary Valve Stenosis / Q000150:complications* / Q000151:congenital; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; C025090:ONO 1206; D000527:Alprostadil