History of the development of pertussis vaccine.
Bordetella pertussis and the disease whooping cough have mysterious unique features among bacterial infectious diseases. Numerous studies gradually provided information that permitted the development of a pertussis vaccine and the assessment of its potency relative to human efficacy. The advances in the understanding of B. pertussis, its pathogenicity and immunity that led to the development of a pertussis vaccine are presented.
Pittman
M
M
Center for Biologics Evaluation and Research, USA Food and Drug Administration, Bethesda, MD 20892.
D000818:Animals; D001886:Bordetella pertussis / Q000302:isolation & purification; D049673:History, 20th Century; D006801:Humans; D010567:Pertussis Vaccine / Q000266:history* / Q000302:isolation & purification / Q000592:standards; D014917:Whooping Cough / Q000266:history / Q000517:prevention & control
D010567:Pertussis Vaccine