Treatment of experimental trypanosomiasis in pigs.
The therapeutic activity of difluoromethylornithine (DFMO), diminazene aceturate (Berenil) and their combination against chronic trypanosomiasis was investigated in experimental Trypanosoma brucei brucei infections of growing pigs. DFMO (300 mg/kg/day orally for 10 days), diminazene aceturate (7 mg/kg in single intramuscular injection) and a combination of the two agents at the above dosages produced varied periods of aparasitaemia in the treated pigs. Relapse parasitaemia occurred in all treatment groups, with diminazene aceturate providing the longest relief period of 17 days, combination treatment 11 days and DFMO 6 days. The packed cell volume, blood haemoglobin concentration and red cell count values decreased after the pigs were infected with the parasites. The values improved following treatment with the agents and their combination.
Jibike
G I
GI
Department of Veterinary Physiology and Pharmacology, University of Maiduguri, Nigeria.
Anika
S M
SM
D000818:Animals; D004133:Diminazene / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D000518:Eflornithine / Q000627:therapeutic use*; D005260:Female; D008297:Male; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000662:veterinary*
D014344:Trypanocidal Agents; C003915:diminazene aceturate; D004133:Diminazene; D000518:Eflornithine