Epidermal growth factor in human tear fluid: a minireview.
This minireview deals with the presence of epidermal growth factor (EGF) in human tear fluid. It explains the occurrence of EGF in tear fluid, the origin of EGF and its dependency on tear fluid dynamics. The alterations in tear fluid EGF concentrations that occur during diseases of the ocular surface are described and discussed in the context of the current knowledge about the interaction between EGF and EGF receptors. The possible clinical implications of topical treatment with EGF are considered.
van Setten
G B
GB
Department of Ophthalmology, University of Helsinki, Finland.
Tervo
T
T
Viinikka
L
L
Perheentupa
J
J
Tarkkanen
A
A
D004815:Epidermal Growth Factor / Q000032:analysis*; D066246:ErbB Receptors / Q000032:analysis; D005128:Eye Diseases / Q000378:metabolism; D015200:Fluoroimmunoassay; D006801:Humans; D013666:Tears / Q000737:chemistry*; D014945:Wound Healing
D004815:Epidermal Growth Factor; D066246:ErbB Receptors