[Effect of vasorenal hypertension and neodicoumarin on the rheological properties of erythrocytes and the balance of blood electrolytes, heart and abdominal aorta wall in rats].
It has been shown that with vasorenal hypertension, erythrocyte suspension viscosity coefficient increases, the abdominal aorta transmural potential difference decreases with lower levels of Na+, K+, Ca2+, and Mg2+ in plasma, cardiac and abdominal aorta tissue and higher red blood cell Na+ levels. Neodicumarinum, 3 mg/kg, modified Na+ and K+ imbalance in the red blood cell-plasma-abdominal aorta wall system, which had been caused by vasorenal hypertension. At the same time the changes in Ca2+ and Mg2+ levels in the abdominal aorta and heart tissue, as well as the value of red blood cell suspension viscosity coefficient were demonstrated to be effectively abolished with neodicumarinum in a dose of 30 mg/kg.
Pustovalov
A P
AP
Voronkov
I F
IF
Rachkov
A K
AK
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001012:Aorta, Abdominal / Q000187:drug effects / Q000378:metabolism*; D001809:Blood Viscosity / Q000187:drug effects / Q000502:physiology*; D003374:Coumarins / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000378:metabolism*; D004906:Erythrocyte Count / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology*; D006978:Hypertension, Renovascular / Q000188:drug therapy / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
D000959:Antihypertensive Agents; D003374:Coumarins; D004573:Electrolytes
Vliianie vazorenal'noĭ gipertenzii i neodikumarina na reologicheskie svoĭstva eritrotsitov, balans elektrolitov krovi, serdtsa i stenki briushnoĭ aorty krys.