L-tryptophan-induced eosinophilia-myalgia syndrome. I. Report of two cases with pseudoxanthoma-elasticum-like skin changes.
Two female patients who fulfilled the criteria for L-tryptophan-induced eosinophilia-myalgia syndrome (EMS) had, together with morphea-like and fasciitis-like sclerotic changes of the skin, lesions that clinically mimicked pseudoxanthoma elasticum (PXE). Histology was compatible with the diagnosis; electron microscopy did not reveal calcium deposits. PXE-like changes may represent an additional feature of the pleomorphic L-tryptophan-induced EMS.
Mainetti
C
C
Department of Dermatology, Hôpital Cantonal Universitaire, Geneva, Switzerland.
Schmied
E
E
Masouyé
I
I
Chavaz
P
P
Saurat
J H
JH
D016603:Eosinophilia-Myalgia Syndrome / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011561:Pseudoxanthoma Elasticum / Q000139:chemically induced / Q000473:pathology*; D012594:Scleroderma, Localized / Q000139:chemically induced / Q000473:pathology; D012867:Skin / Q000473:pathology; D014364:Tryptophan / Q000009:adverse effects*
D014364:Tryptophan