Use of 111In-labelling to follow tissue distribution of Candida albicans in mice.
Two strains of Candida albicans, a wild type and a derived mutant, were labelled with 111Inoxine. Labelled cells were injected into mice and tissue distribution patterns were determined from 0.5 to 48 h. During the first 4-h post-injection phase, remarkable differences in tissue distribution were observed between the two strains. Radiolabelling of C. albicans with 111Inoxine is shown to be a much more reliable method for determining early tissue distribution patterns in infected animal models than culturing the infected tissue.
Kasi
L P
LP
Department of Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston 77030.
Hopfer
R L
RL
D000818:Animals; D002176:Candida albicans / Q000472:pathogenicity*; D007553:Isotope Labeling; D008297:Male; D051379:Mice; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives*
D009942:Organometallic Compounds; C032950:indium oxine; D015125:Oxyquinoline