title: A rapid method for the determination of cocaine in brain tissue.
abstract: A rapid procedure is described for the extraction and analysis of brain samples for cocaine and benzoylecgonine. Human brain tissue was sectioned at autopsy, and samples were subjected to a lipase digestion, subsequent to solid-phase extraction. The distribution of cocaine and benzoylecgonine throughout different regions of the brain was determined by high-performance liquid chromatography.
authors.affiliation: Department of Pharmacodynamics, University of Illinois, Chicago.
authors.forename: S P
authors.initials: SP
authors.lastname: Browne
authors.forename: C M
authors.initials: CM
authors.lastname: Moore
authors.forename: J
authors.initials: J
authors.lastname: Scheurer
authors.forename: I R
authors.initials: IR
authors.lastname: Tebbett
authors.forename: B K
authors.initials: BK
authors.lastname: Logan
mesh_terms: D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D003042:Cocaine / Q000031:analogs & derivatives* / Q000032:analysis*; D006801:Humans; D008049:Lipase / Q000378:metabolism
chemical_list: C005618:benzoylecgonine; D008049:Lipase; D003042:Cocaine