[The effect of ethacrynic acid on the functions of the gastrointestinal tract].
During in vitro and in situ experiments ethacrynic acid was shown to reduce the gastric secretion in rats, motility of the small intestine in rats and mice, contractions of the ileum of guinea pigs in response to histamine and acetylcholine. The intestinal water and electrolyte absorption in rats decreased too. All these effects of ethacrynic acid are extrarenal.
Aladyshev
A V
AV
Vorontsov
V V
VV
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003864:Depression, Chemical; D004064:Digestive System / Q000187:drug effects*; D004068:Digestive System Physiological Phenomena; D004976:Ethacrynic Acid / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D051381:Rats
D004976:Ethacrynic Acid
Vliianie étakrinovoĭ kisloty na funktsii zheludochno-kishechnogo trakta.