Boundary functions in the control of gene expression.
Recent experiments using stably transformed genes in mouse and Drosophila have demonstrated that elimination of euchromatic position effects can be used as a functional assay for domain boundaries. These studies will lead to an analysis of boundary structure, and in addition will provide clues to the mechanism(s) of gene regulation by higher order chromatin packaging.
Eissenberg
J C
JC
Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, MO 63104.
Elgin
S C
SC
D000818:Animals; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D011401:Promoter Regions, Genetic