t(10;11)(p13-14;q14-21): a new recurrent translocation in T-cell acute lymphoblastic leukemias. Groupe Français de Cytogénétique Hématologique (GFCH).
A workshop held by the "Groupe Français de Cytogénétique Hématologique" has identified a t(10;11)(p13-14;q14-21) in four acute lymphoblastic leukemias of T-cell lineage. The immunophenotypes were consistent with immature thymocytes. This translocation is therefore a new candidate for a recurrent translocation in early T-cell leukemia. A similar translocation has been reported as a rare change in early pre-B lymphoid leukemias and also in myeloid leukemias. It is not known whether the similar cytogenetic changes involve different molecular breakpoints or whether the same rearrangement affects a multipotential stem cell capable of lymphoid and myeloid differentiation.
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor; D002648:Child; D002879:Chromosomes, Human, Pair 10 / Q000648:ultrastructure*; D002880:Chromosomes, Human, Pair 11 / Q000648:ultrastructure*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000276:immunology; D008297:Male; D014411:Neoplastic Stem Cells / Q000276:immunology / Q000648:ultrastructure; D009857:Oncogenes; D014178:Translocation, Genetic
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D005819:Genetic Markers