title: The hexachlorotechnetate reagent in the synthesis, characterization and biodistribution of two novel lipophilic complexes.
abstract: The hexachlorotechnetate reagent has been used to synthesize lipophilic complexes of technetium-99m with polydentate ligands, using ligand exchange reactions and acetonitrile as an aprotic solvent. The complexes isolated were partially characterized by chromatographic (paper and HPLC) and electrophoretic methods. Preliminary data on biodistribution studies, carried out in rabbits, are also presented. This work documents that the hexachlorotechnetate reagent is a suitable intermediate for the rapid synthesis of new lipophilic complexes of technetium-99m.
authors.affiliation: Radiopharmacy Program, School of Pharmacy, University of Southern California, Los Angeles 90033.
authors.forename: J K
authors.initials: JK
authors.lastname: Amartey
authors.forename: W
authors.initials: W
authors.lastname: Wolf
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D008099:Liver / Q000378:metabolism; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011817:Rabbits
chemical_list: D015609:Organotechnetium Compounds