The kinetics of chemical reaction of activated nitrosamine with organic substrates.
The chemical reaction of tosylated N-nitrosobis (2-hydroxylpropyl) amine with aniline, 1-naphthol, pyridine, and hydroxylamine follows kinetics which can be described in a mixed order rate equation. This nitrosamine, considered an activated nitrosamine with a potential for alkylating a substrate, was seen to alkylate aniline, pyridine, 1-naphthol, and hydroxylamine. The presence of salts in the solution as well as an increase in solution pH increased the rate of reaction of the nitrosamine with substrates. The nitrosamine reacts quickly with water but will not react with solvents such as acetonitrile, dimethylsulfoxide, and methylene chloride.
Bartzatt
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Eppley Institute, University of Nebraska Medical Center, Omaha 68198.
Nagel
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D
D000477:Alkylating Agents / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D019811:Hydroxylamine; D006898:Hydroxylamines / Q000737:chemistry; D007700:Kinetics; D013058:Mass Spectrometry; D009284:Naphthols / Q000737:chemistry; D009602:Nitrosamines / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D000477:Alkylating Agents; D000814:Aniline Compounds; D006898:Hydroxylamines; D009284:Naphthols; D009602:Nitrosamines; D011725:Pyridines; C029350:1-naphthol; D019811:Hydroxylamine; C012457:diisopropanolnitrosamine