Specific crystal chemical interactions between carcinogenic aromatic compounds and cholesterol.
Polycyclic aromatic hydrocarbons and aromatic amines exercise a highly specific influence on the crystallization of cholesterol. The strength of these non-covalent, presumably epitaxial interactions correlates with the carcinogenic activity of these substances. The presented results are in support of the assumption that a specific process of adsorption and crystallization with cholesterol of the plasma membrane takes place during the initial phase of the carcinogenesis by aromatic compounds.
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B
Technische Fachhochschule Berlin, Fachbereich Chemie- und Biotechnik, Bundesrepublik Deutschland.
D000588:Amines; D000818:Animals; D002273:Carcinogens / Q000737:chemistry*; D002784:Cholesterol / Q000737:chemistry*; D003460:Crystallization; D008954:Models, Biological; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000588:Amines; D002273:Carcinogens; D011083:Polycyclic Compounds; D002784:Cholesterol