Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.
Kozikowski
A P
AP
Neurochemistry Research and Neuropharmacology Research, Mayo Clinic Jacksonville, Florida 32224.
Miller
C P
CP
Yamada
F
F
Pang
Y P
YP
Miller
J H
JH
McKinney
M
M
Ball
R G
RG
D000470:Alkaloids; D000818:Animals; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D066298:In Vitro Techniques; D008958:Models, Molecular; D008968:Molecular Conformation; D051381:Rats; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes; C050426:huperzine A