title: Synthesis and studies of alkynyl pyrimidinones as metaphase inhibitors.
abstract: Methods are described for the syntheses of chloromethyl propargyl ethers and propargyl halides substituted with a hydroxyalkyl group, and their use in alkylation reactions of 2-pyrimidinones. The N-alkynyl derivatives are reversible inhibitors of mitosis in the metaphase of the cell-cycle. The in vivo screening was on Chang liver cells.
authors.affiliation: Department of Chemistry, University of Oslo, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Benneche
authors.forename: G
authors.initials: G
authors.lastname: Keilen
authors.forename: J
authors.initials: J
authors.lastname: Solberg
authors.forename: R
authors.initials: R
authors.lastname: Oftebro
authors.forename: K
authors.initials: K
authors.lastname: Undheim
mesh_terms: D000478:Alkylation; D002478:Cells, Cultured; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects; D008677:Metaphase / Q000187:drug effects*; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D011744:Pyrimidinones