title: Growth inhibitions on human cancer cell cultures with the indole sulphur-containing phytoalexins and their analogues.
abstract: Cell growth inhibitions on human cancer cell cultures were determined for the indole sulphur-containing phytoalexins cyclobrassinin, brassilexin (previously isolated from vegetables of the Cruciferae family) and their synthetic analogues 5-methoxybrassilexin and homocyclobrassinin. The most biologically active of these products is brassilexin (LD50 = 8 micrograms/ml).
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, Gif sur Yvette, France.
authors.forename: C
authors.initials: C
authors.lastname: Tempête
authors.forename: M
authors.initials: M
authors.lastname: Devys
authors.forename: M
authors.initials: M
authors.lastname: Barbier
mesh_terms: D002455:Cell Division / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D007624:KB Cells; D010936:Plant Extracts / Q000494:pharmacology*; D012717:Sesquiterpenes; D013329:Structure-Activity Relationship; D013455:Sulfur; D013729:Terpenes; D014675:Vegetables; D000094162:Phytoalexins
chemical_list: D007211:Indoles; D010936:Plant Extracts; D012717:Sesquiterpenes; D013729:Terpenes; D013455:Sulfur; D000094162:Phytoalexins