[The indices of the lipid peroxidation and desaturation of the blood serum in diabetes mellitus in children].
Comparative investigation of indices of lipid peroxidation and blood lipid unsaturation was carried out in 91 pediatric inpatients (aged 7 to 15) with type I diabetes mellitus and in 10 controls of the same age. Activation of free radical lipid peroxidation was shown to occur in children with diabetes mellitus. A degree of compensation of diabetes did not influence the level of hydroxyperoxides (HP) and final decay products (FP) of lipid peroxidation. In ketoacidotic decompensation HP and FP concentrations in the patients were increased as compared to those in the controls by 284 and 255%, respectively. At the same time children who were admitted in coma, demonstrated low values of blood lipid unsaturation. Insulin therapy (irrespective a drug dose) was accompanied by a 1.8-2-fold increase (p less than 0.05) in a HP level as compared to control values. Change in the level of lipid unsaturation depended upon a daily dose of insulin. In diabetes over 1 year different types of changes in lipid peroxidation and unsaturation were detected, and individual differences in their levels required a differentiated approach to therapeutic tactics.
Turkina
T I
TI
Marchenko
L F
LF
Zezerov
A E
AE
Pozniak
T I
TI
Martynova
M I
MI
Kiseleva
E V
EV
D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000188:drug therapy; D005609:Free Radicals; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood*
D005609:Free Radicals; D007328:Insulin; D008055:Lipids
Pokazateli perekisnogo okisleniia i nenasyshchennosti lipidov syvorotki krovi pri sakharnom diabete u deteĭ.