Electrical potential difference across the stomach wall and gastric morphology in anaesthetized pigs after intravenous administration of cytotoxic drugs.
Nausea and vomiting are frequent side-effects of cancer chemotherapy. To investigate whether such therapy has an acute toxic effect on the gastric mucosa, cyclophosphamide, epirubicin and fluorouracil were administered intravenously to anaesthetized pigs. Gastric mucosal function was evaluated by continuous measurements of the gastric transmucosal electrical potential difference (PD) and the intragastric pH by using a newly developed microelectrode principle. After sacrifice, gastric histology was examined. During chemotherapy a significant decline in gastric PD was observed two hours after drug infusion, indicating a hampered gastric mucosal function. Apart from a slight hyperemia, gastric histology was normal. In this animal model a change in gastric mucosal function developed at the same time after chemotherapy as the gastric side-effects in humans.
Fabrin
B
B
Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, Denmark.
Højgaard
L
L
Johansen
A
A
Olesen
H P
HP
Madsen
J
J
Mouridsen
H T
HT
D000758:Anesthesia; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D013270:Stomach / Q000187:drug effects* / Q000502:physiology; D013552:Swine