Effects of laminin on functional reinnervation of target organs by regenerating axons.
Reinnervation of sweat glands, skeletal muscle and skin was studied in the mouse paw after section of the sciatic nerve and repair by entubulation with collagen conduits, with and without a coating of laminin. After operation, sweat glands activated by pilocarpine reappeared at 32 days and increased in number to 67% of control counts. Muscle action potentials (during sciatic nerve stimulation) were recorded from the interosseus muscle at 39 days. The potential amplitudes increased to 30% of controls. The first withdrawal response from pin prick to the paw was observed at about 34 days, the response score increasing to 66% of control. There were no significant differences at any test interval between the control group and the group with laminin added.
Navarro
X
X
Department of Neurology, University of Minnesota, Minneapolis 55455.
Kennedy
W R
WR
Stewart
N J
NJ
Furcht
L T
LT
D000818:Animals; D001369:Axons / Q000502:physiology*; D003714:Denervation; D004594:Electrophysiology; D005528:Foot; D007797:Laminin / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000294:innervation / Q000502:physiology; D009416:Nerve Regeneration / Q000187:drug effects*; D012584:Sciatic Nerve / Q000502:physiology; D012677:Sensation / Q000502:physiology; D012867:Skin / Q000294:innervation; D013545:Sweat Glands / Q000294:innervation / Q000378:metabolism
D007797:Laminin