Immunohistochemical expression of epidermal growth factor receptors in nuclei of a subpopulation of keratinocytes and sweat gland cells.
We have raised a polyclonal antibody to the 170-kD epidermal growth factor receptor. We found an intercellular pattern of immunoreactivity in the epidermis as well as a positivity of the cytoplasm of keratinocytes and eccrine secretory cells. In some samples, a nuclear labelling was evidenced in these type of cells. There is a close resemblance in the topographical distribution of these cells with nuclear labelling and those synthesizing DNA under phytohaemagglutinin stimulation.
Piérard-Franchimont
C
C
Department of Dermatopathology, University of Liège, Belgium.
Colige
A
A
Arrese Estrada
J
J
Lapière
C M
CM
Piérard
G E
GE
D002462:Cell Membrane / Q000737:chemistry; D002467:Cell Nucleus / Q000737:chemistry; D066246:ErbB Receptors / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000737:chemistry* / Q000648:ultrastructure; D013545:Sweat Glands / Q000737:chemistry* / Q000648:ultrastructure
D066246:ErbB Receptors