title: [Chronic lymphatic leukemia. I. Clinico-biological features and survival analysis. Study of 187 patients].
abstract: A review was carried out of 187 previously untreated cases of chronic lymphocytic leukaemia diagnosed between 1969 and 1988. The median age of the patients was 65 years (range, 36-87). There were 118 males (M/F ratio, 1.7). In accordance with Rai's staging system the patients were distributed as follows: 0.29%; I, 20%; II, 25%; III, 13%; IV, 13%, and according to Binet's staging the distribution was: A, 55%; B, 21%; C, 24%. The most frequently found physical findings were lymph node enlargement (55%), splenomegaly (32%) and hepatomegaly (28%). Anaemia was present in 20% of the cases and thrombocytopenia in 13%. The mean lymphocyte count was 62 x 10(9)/L (range, 6-475 x 10(9)/L). Bone marrow infiltration of over 80% was seen in 46% of the patients. Bone marrow biopsy was performed on 97 patients, the diffuse pattern of involvement being most commonly found (44%). Increased BUN (55%), alkaline phosphatase (42%) and LDH (38%) were the most frequent biochemical alterations. Hypogammaglobulinaemia was present in 55% of the patients, IgM being the most commonly affected immunoglobulin (66%). Monoclonal gammopathy was seen in 4% of the cases. LDT, measured in 75 patients, was less than a year in 32%. No antileukaemic drugs were needed in 34% of the patients. When concluding this study, 100 patients had died. The median survival was 57 months and death was related to chronic lymphocytic leukaemia in 53% of such patients.
authors.affiliation: Hospital Universitario La Fe, Valencia.
authors.forename: I
authors.initials: I
authors.lastname: Jarque
authors.forename: G
authors.initials: G
authors.lastname: Sanz
authors.forename: F
authors.initials: F
authors.lastname: Gomis
authors.forename: G
authors.initials: G
authors.lastname: Martínez
authors.forename: J
authors.initials: J
authors.lastname: de la Rubia
authors.forename: F
authors.initials: F
authors.lastname: López
authors.forename: M A
authors.initials: MA
authors.lastname: Sanz
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis
vernacular_title: Leucemia linfática crónica (I). Características clínico-biológicas y análisis de supervivencia. Estudio de 187 pacientes.