Topical application of ciclosporin ophthalmic solution containing alpha-cyclodextrin in experimental uveitis.
Ciclosporin (CS) has been shown to be a potent immunosuppressive drug. However, systemic administration of CS has been limited because of its unfavourable side effects. Thus, our attention has been focused on a topical application of CS for ophthalmic diseases. In this study, we examined the influence of a topical application of CS on experimentally induced ocular inflammation. CS was prepared by a new drug delivery system, with alpha-cyclodextrin (CD) as a solvent. Topical 0.075% CD-CS reduced ocular inflammation of rabbits induced by intravitreal injection of bovine serum albumin. The magnitude of efficacy of topical 0.075% CD-CS fell within the same level as that of topical 0.02% fluorometholone. However, the topical CD-CS showed no effect on experimental autoimmune uveitis in rats which had been induced by S-antigen or interphotoreceptor retinoid-binding protein. These findings indicate that the topical CD-CS is effective on anterior uveitis.
Sasamoto
Y
Y
Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan.
Hirose
S
S
Ohno
S
S
Onoé
K
K
Matsuda
H
H
D000287:Administration, Topical; D000818:Animals; D000941:Antigens; D019393:Arrestin; D003505:Cyclodextrins / Q000008:administration & dosage*; D016572:Cyclosporine / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004337:Drug Carriers; D005136:Eye Proteins; D008297:Male; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D010726:Phosphodiesterase Inhibitors; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew; D012177:Retinol-Binding Proteins; D014605:Uveitis / Q000188:drug therapy* / Q000276:immunology; D014822:Vitreous Body; D047391:alpha-Cyclodextrins; D000099214:Retinol-Binding Proteins, Interstitial
D000941:Antigens; D019393:Arrestin; D003505:Cyclodextrins; D016572:Cyclosporine; D004337:Drug Carriers; D005136:Eye Proteins; D009883:Ophthalmic Solutions; D010726:Phosphodiesterase Inhibitors; D012177:Retinol-Binding Proteins; D047391:alpha-Cyclodextrins; D000099214:Retinol-Binding Proteins, Interstitial; C032613:alpha-cyclodextrin