Reversal of indomethacin-induced inhibition of implantation in the mouse by epidermal growth factor.
In the mouse, estriol (E3) can induce implantation as a phase I of estrogen action. E3-induced implantation was attenuated by indomethacin(INDO), an inhibitor of prostaglandin (PG) synthesis. The inhibitory effect of INDO was reversed by administration of epidermal growth factor (EGF), and this EGF effect was dose-dependent. These results suggest that one of the functions of estrogen could be to activate the EGF ligand-receptor signalling in the uterus in generating PGs required for initiation of implantation. This is consistent with the results of EGF stimulation of synthesis of PGs in uterine stromal cells in culture.
Paria
B C
BC
Department of Obstetrics & Gynecology, University of Kansas Medical Center, Ralph L. Smith Research Center, Kansas City 66103.
Das
S K
SK
Gupta
A
A
Dey
S K
SK
D000818:Animals; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects*; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000037:antagonists & inhibitors*; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis; D015398:Signal Transduction; D014599:Uterus / Q000187:drug effects* / Q000502:physiology
D011453:Prostaglandins; D004815:Epidermal Growth Factor; D007213:Indomethacin