In SHR rats, dietary potassium determines NaCl sensitivity in NaCl-induced rises of blood pressure.
The current study tested whether the spontaneously hypertensive rats (SHR) from Charles River Laboratories are resistant or not to NaCl-induced rises of blood pressure and deaths. These rats are fairly NaCl-resistant on a 2.1% high K diet, whereas they are quite susceptible to NaCl-induced hypertension and deaths on a 0.5% normal K diet. Thus, a high K diet strongly protects against a NaCl-induced rise of blood pressure as well as deaths in these SHR rats. Hence the level of dietary K determines the degree of NaCl sensitivity in these SHR rats.
Ganguli
M
M
Department of Medicine, University of Minnesota Hospital & School of Medicine, Minneapolis 55455.
Tobian
L
L
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D011188:Potassium / Q000008:administration & dosage*; D051381:Rats; D011918:Rats, Inbred SHR; D012965:Sodium Chloride / Q000009:adverse effects*; D015996:Survival Rate
D012965:Sodium Chloride; D011188:Potassium