The effect of treatment with recombinant gamma-interferon on adjuvant-induced arthritis in rats.
We have investigated the effects of recombinant rat gamma-interferon (rIFN gamma) on adjuvant-induced arthritis (AA). Lewis rats, inoculated in the left hind-paw with adjuvant (day 0), were given 10(5) U/rat of rIFN gamma daily (days 0 to 20), subcutaneously and intramuscularly on alternate days. rIFN gamma suppressed the secondary phase of swelling of both hind-paw on and after day 18 without influencing the earlier phases, both primary and secondary, of swelling. rIFN gamma also reduced the hind-paw bone lesions, the degree of splenomegaly, and the increase in erythrocyte sedimentation rate and plasma fibrinogen. These results indicate a new aspect of the regulatory role of IFN gamma in chronic inflammation.
Nakajima
H
H
Research Institute, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Takamori
H
H
Hiyama
Y
Y
Tsukada
W
W
D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D001799:Blood Sedimentation; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005528:Foot; D007213:Indomethacin / Q000494:pharmacology; D007371:Interferon-gamma / Q000627:therapeutic use*; D009161:Mycobacterium; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011994:Recombinant Proteins; D013154:Spleen / Q000187:drug effects
D011994:Recombinant Proteins; D007371:Interferon-gamma; D005340:Fibrinogen; D007213:Indomethacin