Effect of BAY U 3405, a new thromboxane antagonist, on sudden death in rabbits.
We studied the effects of BAY U 3405 in experimental models of arachidonic acid- and collagen-induced sudden death. BAY U 3405 was effective in dose-dependently inhibiting death from both arachidonic acid and collagen at doses of 1, 3 and 10 mg/kg orally. The survival rate, usually amounting to less than 10% in vehicle-treated animals, was dramatically increased to 100% at the highest dose. The data obtained emphasize the role of thromboxane A2 as a mediator in this model, and the potential usefulness of BAY U 3405 for thromboembolic disorders.
Seuter
F
F
Bayer AG, Institut für Pharmakologie, Chem. Wiss. Labor Pharma, Wuppertal, F.R.G.
Perzborn
E
E
Fiedler
V B
VB
Rosentreter
U
U
Böshagen
H
H
D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002227:Carbazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003094:Collagen / Q000494:pharmacology; D003645:Death, Sudden; D004305:Dose-Response Relationship, Drug; D008297:Male; D011817:Rabbits; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013923:Thromboembolism / Q000517:prevention & control; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors*
D002227:Carbazoles; D013449:Sulfonamides; D016718:Arachidonic Acid; D013928:Thromboxane A2; D003094:Collagen; C063119:ramatroban