title: Micronization by means of supercritical fluids: possibility of application to pharmaceutical field.
abstract: The state of the art in drug micronization is briefly reviewed. The Authors propose and discuss the adoption of a new micronization technique based on supercritical fluids properties: high solvent power and selectivity, fast solute precipitation. A supercritical spray apparatus that has been designed to maximize micronization of pharmaceutical interest products is described. A preliminary scanning of supercritical solvents and cosolvents suitable to dissolve poorly soluble products is also proposed.
authors.affiliation: Istituto di Ingegneria Chimico-Alimentare, Facoltà di Ingegneria, Università di Salerno.
authors.forename: G
authors.initials: G
authors.lastname: Donsì
authors.forename: E
authors.initials: E
authors.lastname: Reverchon
mesh_terms: D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods*