Long-term carcinogenicity bioassays on industrial chemicals and man-made mineral fibers, at the Bentivoglio (BT) laboratories of the Bologna Institute of Oncology: premises, programs, and results.
After having stressed the need of primary prevention in the strategy for cancer control, the crucial role of the long-term carcinogenicity bioassays in providing scientific support to primary prevention has been focused. The state-of-the-art, the present inadequacies, the necessity of implementation, and the perspectives of the long-term carcinogenicity bioassays have been briefly reviewed. The performed and ongoing programs of carcinogenicity bioassays at the Bentivoglio (BT) Laboratories of the Bologna Institute of Oncology have been presented, together with the currently available results on several compounds of industrial and commercial relevance.
Maltoni
C
C
Institute of Oncology F. Addarii, Bologna, Italy.
Minardi
F
F
Soffritti
M
M
Lefemine
G
G
D001681:Biological Assay; D015197:Carcinogenicity Tests / Q000379:methods; D002617:Chemical Industry; D004784:Environmental Monitoring; D006801:Humans; D007558:Italy; D008903:Minerals / Q000009:adverse effects*; D009369:Neoplasms / Q000517:prevention & control*; D012307:Risk Factors; D013997:Time Factors
D008903:Minerals