Synergistic interaction of methotrexate and 6-mercaptopurine in human derived malignant T-ALL and CALLA+ cell lines.
De Abreu
R A
RA
Centre for Pediatric Oncology SE Netherlands, Department of Pediatrics, University Hospital Nijmegen.
van Strien
F
F
Lambooy
L H
LH
Bökkerink
J P
JP
D002250:Carbon Radioisotopes; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D005998:Glycine / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D015459:Leukemia-Lymphoma, Adult T-Cell; D015122:Mercaptopurine / Q000494:pharmacology*; D008727:Methotrexate / Q000494:pharmacology*; D010710:Phosphates / Q000378:metabolism; D010761:Phosphorus Radioisotopes; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; D011687:Purines / Q000378:metabolism; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D013938:Thymidine Monophosphate / Q000378:metabolism
D002250:Carbon Radioisotopes; D010710:Phosphates; D010761:Phosphorus Radioisotopes; D011687:Purines; D013938:Thymidine Monophosphate; D015122:Mercaptopurine; D013762:Tetrahydrofolate Dehydrogenase; D005998:Glycine; D008727:Methotrexate