The human homolog of the mouse brown gene maps to the short arm of chromosome 9 and extends the known region of homology with mouse chromosome 4.
The mouse brown locus encodes a tyrosinase-related protein, TRP-1. The human homolog of TRP-1 was recently cloned from a melanoma cDNA library and sequenced. We have made oligonucleotide primers corresponding to the human TRP1 3' untranslated region and used them to map the human TRP1 gene by species-specific PCR in human/rodent somatic cell hybrids. By this means, the human TRP1 gene has been mapped to the short arm of chromosome 9.
Abbott
C
C
Department of Genetics & Biometry, University College London, England.
Jackson
I J
IJ
Carritt
B
B
Povey
S
S
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D004268:DNA-Binding Proteins; D015723:Gene Library; D006801:Humans; D006822:Hybrid Cells; D008545:Melanoma / Q000235:genetics; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D015534:Trans-Activators
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D015534:Trans-Activators