[Experimental substantiation of using gentacycol for prevention of wound infection in gunshot bone fractures of the extremities].
There have been experimentally studied the antibacterial properties of the preparation "gentacycol" developed in the research institute of antibiotics. Its effective agent is gentamycin and as the matrix of a carrier modified collagen is used. It is indicated that in vitro and at implantation in preliminary infected ordinary and gunshot osseous wounds in rabbits and dogs gentacycol inhibits the growth of aerobic and, that is especially important, anaerobic microflora, limits the development of inflammatory Process and stimulates, to a certain extent, reparative osteogenesis. The obtained data allows to recommend gentacycol application for prophylaxis of wound infection in treatment of gunshot limb bone injuries.
Shaposhnikov
Iu G
IuG
Kaveshnikov
A I
AI
Kroĭtor
G M
GM
Okropiridze
G G
GG
Lipkin
S I
SI
D000818:Animals; D001134:Arm Injuries / Q000150:complications* / Q000382:microbiology; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005552:Forelimb / Q000293:injuries / Q000382:microbiology; D050723:Fractures, Bone / Q000150:complications* / Q000382:microbiology; D005839:Gentamicins / Q000008:administration & dosage*; D006614:Hindlimb / Q000293:injuries / Q000382:microbiology; D006801:Humans; D007869:Leg Injuries / Q000150:complications* / Q000382:microbiology; D011817:Rabbits; D014946:Wound Infection / Q000209:etiology / Q000517:prevention & control*; D014948:Wounds, Gunshot / Q000150:complications* / Q000382:microbiology
D005839:Gentamicins
Eksperimental'noe obosnovanie primeneniia gentatsikola dlia profilaktiki ranevoĭ infektsii pri ognestrel'nykh perelomakh kosteĭ konechnoste'i.