Influence of ouabain of electrolyte and water transport in the rabbit ileum and colon in vitro and in vivo.
We studied the influence of the Na(+)-K+ pump inhibitor ouabain on water and electrolyte transport in the rabbit distal ileum and proximal colon in vitro and in vivo. Under in vitro conditions, ouabain markedly reduced the absorption of water, sodium, chloride and bicarbonate, and reduced potassium secretion in both the ileum and the colon. In vivo results were similar but less marked than those obtained in vitro, with significant differences only at the level of the distal ileum.
Galindo
M C
MC
Department of Physiology, Faculty of Pharmacy, University of Granada, Spain.
Campos
M S
MS
Garcia
J A
JA
Lisbona
F
F
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D001834:Body Water / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D004573:Electrolytes / Q000378:metabolism*; D007082:Ileum / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010042:Ouabain / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D012964:Sodium / Q000378:metabolism
D001639:Bicarbonates; D002712:Chlorides; D004573:Electrolytes; D010042:Ouabain; D012964:Sodium; D011188:Potassium