title: Participation and adherence among older men and women recruited to the Beta-Carotene and Retinol Efficacy trial (CARET).
abstract: We evaluated as functions of age and gender participation and adherence rates in older adults recruited to pilot studies for CARET, a multicenter chemoprevention trial. Eligible were men and women aged 50-69 who were current or recent former smokers, and men aged 45-74 with occupational exposure to asbestos. We found negligible differences by age in response to recruitment mailings, drop out during the enrollment process and after randomization, and adherence to taking the study capsules. Men had numerically lower drop-out and higher adherence rates than women, but differences were not statistically significant. These results should encourage researchers to recruit older men and women (at least up to age 69) to clinical trials.
authors.affiliation: Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, University of Washington, Seattle 98195.
authors.forename: M D
authors.initials: MD
authors.lastname: Thornquist
authors.forename: D L
authors.initials: DL
authors.lastname: Patrick
authors.forename: G S
authors.initials: GS
authors.lastname: Omenn
mesh_terms: D000367:Age Factors; D000368:Aged; D002338:Carotenoids / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003256:Community Participation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010865:Pilot Projects; D011322:Primary Prevention; D012737:Sex Factors; D014801:Vitamin A / Q000627:therapeutic use; D019207:beta Carotene
chemical_list: D019207:beta Carotene; D014801:Vitamin A; D002338:Carotenoids