[Effect of delayed-action Mirenil (Polfa) on the hypothalamic function in patients with schizophrenia].
Hormonal tests--TRH, ITT and L-RH--were performed in 10 cases of paranoid schizophrenia before the paranoid deterioration and after--on average--ten months of treatment with fluphenazine depot injection. The drug did show a clear modulating effect on the mechanisms regulating secretion of gonadotrophins and prolactin --it did not effect the secretion of thyrotropin , thyroxine, triiodothyronine, cortisol, growth hormone or insulin .
Horodnicki
J M
JM
Kliniki Psychiatrycznej PAM w Szczecinie.
Pobocha
J
J
D000328:Adult; D003692:Delayed-Action Preparations; D005260:Female; D005476:Fluphenazine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010906:Pituitary Hormone-Releasing Hormones / Q000378:metabolism / Q000502:physiology*; D011044:Poland; D011388:Prolactin / Q000378:metabolism*; D012563:Schizophrenia, Paranoid / Q000188:drug therapy* / Q000503:physiopathology
D003692:Delayed-Action Preparations; D006065:Gonadotropins, Pituitary; D010906:Pituitary Hormone-Releasing Hormones; D011388:Prolactin; C011825:fluphenazine depot; D005476:Fluphenazine
Wpøyw mirenilu prolongatum (Polfa) na czynność podwzgórza u chorych z rozpoznaniem schizofrenii.