Immunoglobulin heavy-chain allotypes play a role in the clinical history of celiac disease.
We studied the role of the immunoglobulin heavy-chain allotypes in the evolution of celiac disease. Particularly the Gm(fb) phenotype was investigated since this phenotype is able to determine the breadth of immune response against alpha-gliadin antigen. The results show that weight percentiles and intestinal absorption as assessed by xylose test are influenced by Gm(fb) phenotype suggesting that Gm(fb) genes contribute to the determination of clinical aspects and evolution of celiac disease.
Caruso
C
C
Istituti di Patologia generale, Università di Palermo, Italia.
Candore
G
G
Lio
D
D
Modica
M A
MA
Cataldo
F
F
Maltese
I
I
Marino
V
V
Albeggiani
A
A
D000293:Adolescent; D001835:Body Weight; D002446:Celiac Disease / Q000178:diet therapy / Q000235:genetics* / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005803:Genes, Immunoglobulin; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D010641:Phenotype; D014994:Xylose / Q000493:pharmacokinetics
D007129:Immunoglobulin Gm Allotypes; D007143:Immunoglobulin Heavy Chains; D005983:Glutens; D014994:Xylose