Regulation of IgE synthesis by cytokines.
Considerable progress has been made in our understanding of the mechanisms underlying regulation of human IgE synthesis. Interleukin-4 induces IgE production specifically, but costimulatory signals provided by T cells are required. Other cytokines modulate interleukin-4-induced IgE synthesis. The roles of T cells and cytokines in regulating IgE switching are discussed.
de Vries
J E
JE
DNAX Research Institute, Palo Alto, California.
Gauchat
J F
JF
Aversa
G G
GG
Punnonen
J
J
Gascan
H
H
Yssel
H
H
D000916:Antibody Diversity / Q000235:genetics; D005786:Gene Expression Regulation; D005803:Genes, Immunoglobulin; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000235:genetics; D007134:Immunoglobulin Switch Region; D015847:Interleukin-4 / Q000096:biosynthesis / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
D015847:Interleukin-4; D007073:Immunoglobulin E