[Effect of acute carbaryl poisoning on various indicators of amino acid metabolism in rats].
Male Wistar rats were orally poisoned with carbaryl in a single dose 474 mg/kg (1/2 LD50). After 2, 4, 24, 72 and sometimes 120 hours from the administration of the insecticide the studied biochemical parameters have been determined. Trials showed an essential effect of carbaryl on the amino acid balance and metabolism. Significant decreases of the most amino acids concentrations in the brain tissue (a maximum decrease in the second hour) and in the liver (at 4-th h of intoxication). Normalization of the amino acid levels occurred more early in the brain than in the liver. Furthermore a decrease of total keto-acids concentration in erythrocytes (at 4-th h) and activity changes of some plasma and liver plasmatic aminotransferases in the reaction with alpha-ketoglutarate and pyruvate was observed.
Jeleniewicz
K
K
Z Katedry i Zakładu Chemii Toksykologicznej Akademii Medycznej w Lublinie.
D000208:Acute Disease; D000284:Administration, Oral; D000596:Amino Acids / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D012721:Carbaryl / Q000506:poisoning*; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D012721:Carbaryl
Badania wpływu ostrej intoksykacji karbarylem na niektóre wskaźniki przemiany aminokwasowej u szczura.