[The effect of interferon preparations on the ultrastructural organization of Legionella pneumophila].
The influence of the preparations of interferon on morphological changes in L. pneumophila on the ultrastructural level has been studied. Disturbances in the ultrastructure of L. pneumophila result from the direct bactericidal action of interferons without any interference of immune mechanisms. These disturbances are manifested by damages in the cell wall, plasma membrane, nuclear and ribosomal apparatuses of microbial cells. Leukinferon exhibits pronounced anti-Legionella activity, both in vitro in a liquid culture medium and in ovo, than reaferon.
Nebozhina
L V
LV
Klitsunova
N V
NV
Tartakovskiĭ
I S
IS
Kuznetsov
V P
VP
Bykovskiĭ
A F
AF
D000818:Animals; D002642:Chick Embryo; D003470:Culture Media; D016207:Cytokines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D007370:Interferon Type I / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D016952:Legionella pneumophila / Q000187:drug effects* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011994:Recombinant Proteins
D003470:Culture Media; D016207:Cytokines; D004338:Drug Combinations; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; C062252:leukinferon
Vliianie preparatov interferona na ul'trastrukturnuiu organizatsiiu Legionella pneumophila.