Effect of intracanalicular collagen implants on the absorption of topically applied sodium fluorescein.
Absorbable intracanalicular collagen implants were placed in both canaliculi of one eye of nine human volunteers. The other eye served as a control. Twenty-four hours later 2% sodium fluorescein was placed into both conjunctival sacs. Serial corneal fluorescein concentrations were measured with a scanning ocular fluorophotometer from 2 to 90 min after fluorescein administration. The mean corneal fluorescein concentration averaged over all time points was greater in 7 of 9 eyes with collagen implants compared to unimplanted controls. When the data from each subject were analyzed collectively, the mean corneal fluorescein concentration in the implanted eyes (1,218 micrograms/ml +/- SEM 83) was significantly greater (p less than 0.001) than the mean concentration in the control eyes (823 micrograms/ml +/- SEM 83). The use of absorbable intracanalicular collagen implants may increase the bioavailability of topically applied ocular solutions.
Unterman
S R
SR
Department of Ophthalmology, University of Kansas Medical Center, Kansas City 66103.
Reidy
J J
JJ
Hill
J H
JH
Kaufman
H E
HE
D000042:Absorption; D000287:Administration, Topical; D000328:Adult; D001682:Biological Availability; D003094:Collagen; D003315:Cornea / Q000378:metabolism*; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015590:Fluorophotometry; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000378:metabolism*; D008297:Male; D009883:Ophthalmic Solutions / Q000493:pharmacokinetics; D019736:Prostheses and Implants
D005452:Fluoresceins; D009883:Ophthalmic Solutions; D003094:Collagen; D019793:Fluorescein