Localized in vivo proton spectroscopy of the human kidney.
In vivo 1H spectroscopy using the STEAM sequence for localization has been applied to the human kidney in normal volunteers and subjects with successful renal transplants. We show that, within the resolution of our measurements, trimethylamines are present in the spectra from some of the subjects and absent from others. The prominent peak seen at 5.8 ppm in the spectrum is identified as that from urea and not lipid, as previously suggested.
Shah
N J
NJ
Herchel Smith Laboratory for Medicinal Chemistry, University of Cambridge School of Clinical Medicine, England, United Kingdom.
Carpenter
T A
TA
Wilkinson
I D
ID
Hall
L D
LD
Dixon
A K
AK
Freer
C E
CE
Prosser
K
K
Evans
D B
DB
D006801:Humans; D007668:Kidney / Q000033:anatomy & histology* / Q000737:chemistry; D016030:Kidney Transplantation / Q000473:pathology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008744:Methylamines / Q000032:analysis
D008744:Methylamines; C023336:trimethylamine