title: Gentamicin interval in newborn infants as determined by renal function and postconceptional age.
abstract: We evaluated the relationship between gentamicin pharmacokinetics and glomerular filtration rate in newborn infants to estimate the appropriate interval of administration in neonates with renal insufficiency. Gentamicin half-life (Gt1/2) could be predicted from plasma creatinine concentration (PCr) (r = 0.78); the prediction was minimally but significantly increased (r = 0.81) by adding post-conceptional age to a multiple regression analysis. Infants with a postconceptional age of 29 weeks or more and a PCr of 1 mg/dl or more had significantly greater through and peak gentamicin levels than those with a PCr less than 1 mg/dl. If gentamicin is indicated in a patient with renal insufficiency, the interval of administration should be 2-3 Gt1/2, which can be estimated from PCr (Gt1/2 = 2.0 + 7.7 PCr). The interval can then be adjusted according to peak and trough gentamicin levels.
authors.affiliation: Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461.
authors.forename: L P
authors.initials: LP
authors.lastname: Brion
authors.forename: A R
authors.initials: AR
authors.lastname: Fleischman
authors.forename: G J
authors.initials: GJ
authors.lastname: Schwartz
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism* / Q000503:physiopathology; D003404:Creatinine / Q000097:blood; D004334:Drug Administration Schedule; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005865:Gestational Age; D005919:Glomerular Filtration Rate; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D007668:Kidney / Q000503:physiopathology*
chemical_list: D005839:Gentamicins; D003404:Creatinine