[Changes in lipid peroxides in methamphetamine treated rats].
Methamphetamine (MA) has many pharmacological effects. We measured lipid peroxides of MA treated rat by thiobarbituric acid (TBA) reaction to estimate the relationship between free radical reaction and pharmacological effects of MA. In this study we used rat which were injected 1 mg/kg/day MA for 2-10 weeks as the long term groups and which injected 10 mg/kg MA once as the acute groups. Although the acute groups were not different from the control groups, TBA reacting substance was increased in brains of more than 6 weeks treated rat and decreased in lungs of the same groups. These results indicate that lipid peroxidation might be related to chronic MA effects.
Sodesaki
K
K
Department of Forensic Medicine, Saga Medical School.
Matoba
R
R
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011921:Rats, Inbred WKY
D008054:Lipid Peroxides; D008694:Methamphetamine