Linear modeling of the effect of intravenous histamine infusion on rat gastric acid secretion: a biostatistical evaluation by splitting the time-effect curves.
Lumen perfusion experiments have been widely employed for the evaluation of gastric acid secretion in rats. The advantage of the lumen perfusion models is the simplicity in evaluating the effectiveness of secretagogues and antisecretagogues. There is, however, no efficient methodology for biostatistical modeling of gastric acid secretion in lumen-perfused rats. In order to optimize methodology, we applied a linear regression model after splitting the time-effect curves obtained from histamine-induced gastric acid secretion in rats.
Oztürk
Y
Y
Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
Ozçelikay
A T
AT
Altan
V M
VM
Altinkurt
O
O
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000493:pharmacokinetics / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis
D006632:Histamine