title: Absorption of some cephalosporins by rectal route in rabbits.
abstract: In order to obtain an effective alternative to parenteral administration of several cephalosporins, experiments were carried out in rabbits by rectal route. The suppositories of cefotaxime (CTX), ceftazidime (CAZ) and cefoxitin (CFX) in association with surface active sodium lauryl sulfate (SLS), release the antibiotic for absorption. Based on the positive results of the comparative plasmatic levels, this dosage appears to be applicable to humans too.
authors.affiliation: Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, Oporto, Portugal.
authors.forename: M F
authors.initials: MF
authors.lastname: Bahia
mesh_terms: D000285:Administration, Rectal; D000818:Animals; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D013488:Suppositories
chemical_list: D002511:Cephalosporins; D013488:Suppositories