title: Aneuploidy in benign seminal vesicle epithelium: an example of the paradox of ploidy studies.
abstract: To evaluate if the nuclear enlargement and irregularity of non-neoplastic seminal vesicle epithelium were associated with an abnormal DNA content, 30 seminal vesicles obtained from radical prostatectomies were analyzed by flow cytometry. Twenty-eight (93.3%) of the seminal vesicles showed characteristic diploid histograms, while two (6.7%) showed histograms characteristic of aneuploidy. These results are discussed and other reported examples of aneuploidy in nonmalignant tissues are reviewed.
authors.affiliation: Department of Pathology, Scott & White Hospital, Temple, Texas.
authors.forename: D A
authors.initials: DA
authors.lastname: Arber
authors.forename: V O
authors.initials: VO
authors.lastname: Speights
mesh_terms: D000368:Aged; D000782:Aneuploidy; D002453:Cell Cycle; D004247:DNA / Q000032:analysis* / Q000235:genetics; D004171:Diploidy; D005434:Flow Cytometry; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D012669:Seminal Vesicles / Q000378:metabolism* / Q000473:pathology
chemical_list: D004247:DNA