title: [Efficacy and tolerance of LA 50 mg nicardipine in hypertensive athletes].
abstract: The beneficial effects of physical exercise on the blood pressure are widely recognised. Nevertheless, some athletes remain hypertensive and the treatment of this population makes special demands with respect to treatment efficacy and tolerability, the respect of athletic performance and problems of proscribed substances. For example, the Athletic Boards have prohibited betablockers and diuretics in competitive athletes. The aim of this study was to assess nicardipine LA 50 mg administered twice daily in the special context of hypertensive athletes. Thirty-eight athletes with mild or moderate hypertension undergoing endurance training were included in this double blind trial versus placebo. After two months treatment, the systolic and diastolic blood pressures were significantly lower at rest in the nicardipine than in the placebo group (delta SBP = -18.9 vs -4.1 mmHg, p less than 0.001; delta DBP = -15.7 vs -4.1 mmHg, p less than 0.01). In addition the maximum SBP on effort was significantly lower in the nicardipine group (200 vs 215 mmHg, p less than 0.05). On the other hand, no difference was observed between the two groups as regards the maximum oxygen consumption (delta VO2 max = 6.2 vs -0.4 ml/min/kg, NS) and duration of effort (13.75 vs 12.32 min, NS), showing that athletic performance was unchanged in the group treated by nicardipine LA. These results suggest that treatment with nicardipine LA fulfills the special criteria of hypertensive athletes.
authors.affiliation: Clinique Bizet, Paris.
authors.forename: D M
authors.initials: DM
authors.lastname: Marcadet
authors.forename: A S
authors.initials: AS
authors.lastname: Blanc
authors.forename: A A
authors.initials: AA
authors.lastname: Lopez
authors.forename: J P
authors.initials: JP
authors.lastname: Preziosi
authors.forename: M M
authors.initials: MM
authors.lastname: Guignard
authors.forename: S
authors.initials: S
authors.lastname: Baggio
authors.forename: P
authors.initials: P
authors.lastname: Sassano
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004361:Drug Tolerance; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000008:administration & dosage / Q000627:therapeutic use*; D010101:Oxygen Consumption / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects*; D010919:Placebos; D013177:Sports
chemical_list: D003692:Delayed-Action Preparations; D010919:Placebos; D009529:Nicardipine
vernacular_title: Efficacité et tolérance de la nicardipine LP 50 mg dans l'hypertension artérielle du sportif.