[A study on developmental toxicity of vanadium pentoxide in NIH mice].
There is no general agreement yet about the teratogenic effects or developmental toxicity of vanadium in animal studies. This is a report on developmental toxicity in NIH mice following injection of vanadium pentoxide (V2O5, 5 mg/kg body weight, i.p.) at different times of gestation (on days 1-5, 6-15, 7, 8, 9, 10, 11, 14-17 of gestation). No adverse effects of V2O5 on pre-implantation and implantation were noted, and neither were teratogenicity and premature birth. However, there was toxic effect on embryofetus. Increased frequency of resorption or fetal death on days 6-15, 7, 14-17 of gestation were observed. Delayed ossification of bones was noted on days 6-15, 8, 10, 14-17 of gestation. These results suggest that V2O5 may be a weak developmental toxicant but not a teratogen in NIH mice. In addition, this paper reports the developmental toxicity, especially teratogenicity of N, N'-methylene-bis (2-amino-1, 3, 4-thiadiazole) which was used as the positive control in NIH mice.
Zhang
T
T
Department of Environmental Health.
Gou
X
X
Yang
Z
Z
D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced*; D051379:Mice; D010012:Osteogenesis / Q000187:drug effects; D011247:Pregnancy; D014639:Vanadium / Q000633:toxicity*; D017968:Vanadium Compounds
D017968:Vanadium Compounds; D014639:Vanadium; C066075:vanadium pentoxide