[Effects of ulinastatin on granulocyte elastase and fibronectin in patients undergoing cardiopulmonary bypass].
We investigated the effects of ulinastatin on the increase of granulocyte elastase (GEL) and the decrease of fibronectin (FN) after cardiopulmonary bypass (CPB) in 30 patients undergoing cardiopulmonary bypass. Ulinastatin 300,000 units were given immediately after the induction of anesthesia (U1) or during CPB (U2). GEL increased by 20 times after CPB. GEL was lower in U2 than those in other groups. FN increased by 7-13% after CPB in U1 but decreased in other groups. FN decreased by 21-13% on the first postoperative day in three groups. There was a close relationship between CPB time and increase of GEL in the control group (no ulinastatin given) (y = 18.5 x -833, r = 0.751), between CPB time and increase of FN in U1 (y = 1.4 x -163.4, r = 0.683) or increases of GEL and FN in the control group (y = 0.068 x -202.6, r = 0.812). From these results, we recommend that ulinastatin should be given after the induction of anesthesia and during CPB, to keep a favorable host defense function after CPB.
Enzan
K
K
Department of Anesthesiology, Akita University School of Medicine.
Mitsuhata
H
H
Masaki
Y
Y
Matsumoto
J
J
Shigeomi
S
S
Komatsu
H
H
Suzuki
M
M
D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass; D003864:Depression, Chemical; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006023:Glycoproteins / Q000627:therapeutic use*; D006098:Granulocytes / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood*; D013268:Stimulation, Chemical; D014361:Trypsin Inhibitors / Q000627:therapeutic use*
D005353:Fibronectins; D006023:Glycoproteins; D014361:Trypsin Inhibitors; D010196:Pancreatic Elastase; C028665:urinastatin