Furosemide-induced changes in plasma and blood volume of horses.
The effect of furosemide administration (1 mg/kg body weight, i.v.) on plasma and blood volumes in 6 intact and 4 splenectomized horses was measured using Evans blue dye dilution, hematocrit, and hemoglobin and plasma total solids concentrations. Body weight decreased by 33.6 +/- 3.3 and 33.7 +/- 0.8 g/kg 4 h after furosemide administration to intact and splenectomized mares, respectively. Plasma volume, estimated by Evans blue dye dilution, was reduced by 8.3 +/- 3.3% (mean +/- SE) 4 h after furosemide administration. The reduction in plasma volume was first detectable 5-10 min after furosemide administration and was greatest 15-30 min (13.0 +/- 0.8%) after dosing. This study demonstrates that furosemide produces significant and rapid reductions in plasma volume in horses. These decreases in plasma volume only partially resolve 4 h after furosemide administration.
Hinchcliff
K W
KW
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Ohio State University, Columbus 43210.
McKeever
K H
KH
Muir
W W
WW
D000818:Animals; D001810:Blood Volume / Q000187:drug effects*; D004395:Dye Dilution Technique; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis / Q000187:drug effects; D006736:Horses / Q000097:blood*; D010953:Plasma Volume / Q000187:drug effects*; D013156:Splenectomy / Q000662:veterinary; D015431:Weight Loss / Q000187:drug effects
D006454:Hemoglobins; D005665:Furosemide