title: [Dumbbell neuroblastoma. Experience at the Gustave Roussy Institute in 38 cases treated from 1982 to 1987].
abstract: Among the 282 neuroblastomas treated at the Institut Gustave-Roussy between 1982 and 1987, 38 dumbbell forms were observed. Therapeutic approaches included: 1) An initial laminectomy in forms with neurological deficit; 2) Surgical excision of the primary tumor; 3) Preoperative chemotherapy for metastatic forms and non-metastatic forms in which primary tumors considered unresectable at diagnosis; 4) Radiation therapy on macroscopic residual disease. Twenty three of 38 children presented with a neurological deficit. A laminectomy was performed in 21 cases. Neurological recovery was good in 8 cases, partial in 5 cases and absent in 5 cases. Three patients were aggravated after the procedure. The event free survival was 76%. This high survival rate is linked with: 1) The predominantly non metastatic stages (25/38); 2) A high proportion of children under 1 year of age (25/38); 3) A high proportion of thoracic locations. Out of the 29 survivors, there were 10 cases of major neurological sequelae (34%) and 9 cases of major orthopedic sequelae (31%). The coexistence of a serious functional prognosis and an excellent vital prognosis led us to analyse the therapeutic modalities and reevaluate the necessity of routine initial neurosurgical excision by laminectomy, and using a first line chemotherapy in selected indications.
authors.affiliation: Service de Pédiatrie, Institut Gustave-Roussy, CHU de Grenoble.
authors.forename: D
authors.initials: D
authors.lastname: Plantaz
authors.forename: O
authors.initials: O
authors.lastname: Hartmann
authors.forename: C
authors.initials: C
authors.lastname: Kalifa
authors.forename: C
authors.initials: C
authors.lastname: Sainte-Rose
authors.forename: J G
authors.initials: JG
authors.lastname: Passagia
authors.forename: J
authors.initials: J
authors.lastname: Lemerle
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D015174:Epidural Neoplasms / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007796:Laminectomy; D008297:Male; D009447:Neuroblastoma / Q000150:complications / Q000628:therapy*; D011379:Prognosis; D013117:Spinal Cord Compression / Q000209:etiology / Q000628:therapy
vernacular_title: Neuroblastomes en sablier. Expérience de l'Institut Gustave-Roussy sur 38 cas traités de 1982 à 1987.