Dietary lipid modification of renal disorders and ether phospholipid metabolism.
The formation of arachidonic acid derived eicosanoids, including thromboxane A2 and leukotriene B4, as well as platelet-activating factor (1-O-alkyl-2-acetyl-glycerophosphocholine), has been implicated in various renal pathophysiologies. Alteration of the fatty acid composition of membrane phospholipids in platelets, the glomerulus, and inflammatory cells, and of 1-O-alkyl-2-acyl-glycerophosphocholine (platelet-activating factor precursor) can be attained by dietary lipid modifications (e.g., consumption of fish oil containing n - 3 polyunsaturated fatty acids). These changes have been associated with an attenuation in renal disease progression and modifications in the synthesis and actions-interactions of eicosanoids, cytokines, and platelet-activating factors.
Holub
B J
BJ
Department of Nutritional Sciences, University of Guelph, Ont., Canada.
Philbrick
D J
DJ
Parbtani
A
A
Clark
W F
WF
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D015777:Eicosanoids / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D007674:Kidney Diseases / Q000178:diet therapy* / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D010742:Phospholipid Ethers / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000378:metabolism
D016207:Cytokines; D004042:Dietary Fats, Unsaturated; D015777:Eicosanoids; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008563:Membrane Lipids; D010742:Phospholipid Ethers; D010972:Platelet Activating Factor