title: [A preclinical study of the organ distribution and radiation dosage of radioiodinated iodolisuride].
abstract: The distribution in rats of 125I-iodo-lisuride was studied. Three rats each were sacrificed at fixed intervals between 5 min and 24 h p.i., and the radioactivity was measured in isolated organs and parts of the body. The organ distribution and biexponential blood disappearance were similar to values for unlabeled lisuride. The radiation dose was estimated for man assuming a 123I label. The resulting doses were comparable to those from other radiopharmaceuticals in clinical use.
authors.affiliation: Klinik für Nuklearmedizin, Fakultät (Charité), Humboldt-Univ., Berlin, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Buchali
authors.forename: H
authors.initials: H
authors.lastname: Flade
authors.forename: B
authors.initials: B
authors.lastname: Johannsen
authors.forename: V
authors.initials: V
authors.lastname: Pink
authors.forename: U
authors.initials: U
authors.lastname: Herold
authors.forename: R
authors.initials: R
authors.lastname: Harhammer
authors.forename: R
authors.initials: R
authors.lastname: Horowski
mesh_terms: D000818:Animals; D007457:Iodine Radioisotopes; D008090:Lisuride / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008297:Male; D011829:Radiation Dosage; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D008090:Lisuride
vernacular_title: Vorklinische Untersuchung zur Organverteilung und Strahlenbelastung von Radiojod-Jodlisurid.