[Prevention and treatment of isoproterenol induced ventricular fibrillation in rats by aqueous extract of Salvia miltiorrhiza].
Acute fatal ventricular fibrillation (VF) in male Sprague-Dawley rats was induced by subcutaneous injection of isoproterenol (1 mg or 5 mg/kg body weight) to two groups of rats of different body weights (525 +/- 21 g or 387 +/- 11 g) respectively. VF occurred in all control rats resulting in 96% death with only 4% spontaneously reverted and survived. Pretreatment of animals, with or without pentobarbital anaesthesia, with an aqueous extract of Salvia miltiorrhiza (SM-H, i.p., 5 g herb/kg body weight) significantly reduced J-point displacement and VF induced by isoproterenol. Survival rate was significantly raised compared with the control (P less than 0.05). Immediate intravenous injection of SM-H (5 g herb/kg body weight) to poisoned rats which developed VF caused 71% of them to recover temporarily their sinus rhythm and significantly prolonged their survival time (P less than 0.05).
Cheng
Y Y
YY
Chinese Medicinal Material Research Centre, Chinese University of Hong Kong.
Fong
S M
SM
Hon
P M
PM
Li
C M
CM
Chang
H M
HM
D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008297:Male; D009638:Norepinephrine; D010618:Phenanthrolines / Q000627:therapeutic use*; D010936:Plant Extracts; D051381:Rats; D011919:Rats, Inbred Strains; D027561:Salvia miltiorrhiza; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010618:Phenanthrolines; D010936:Plant Extracts; C028972:dan-shen root extract; D009638:Norepinephrine