[Limitation of the cardiac depressive effect caused by various forms of staphylococcal infection by using dalargin, a synthetic analog of endogenous opioids].
Male Wistar rats were used to examine the cardiodepressive action of experimentally induced generalized infection and bacterial shock and the ability of the synthetic opioid dalargin to enhance resistance the damaging effect of bacterial intoxication. The cardiac performance of the infected rats was studied in a model of an isolated perfused heart with the working left ventricle. In the rats, generalized Staphylococcus infection was ascertained to result in a dose-dependent inhibition of heart performance at all study stages, showing the peak of cardiodepressive action on days 3 of postinfection. The experimental animals given dalagin displayed a high infection resistance, as manifested predominantly by prevented profound cardiac disorders due to systemic administration of dalargin or by a positive inotropic effect of the drug supplemented to perfusate, the effect being particularly pronounced in bacterial shock or in early generalized infection.
Pashutin
S B
SB
Zinov'eva
T D
TD
D000818:Animals; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000209:etiology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D008297:Male; D010919:Placebos; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000150:complications* / Q000503:physiopathology; D013203:Staphylococcal Infections / Q000150:complications* / Q000503:physiopathology; D013211:Staphylococcus aureus
D010919:Placebos; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Ogranichenie kardiodepressivnogo deĭstviia, vyzvannogo razlichnymi formami stafilokokkovoĭ infektsii, pri ispol'zovanii sinteticheskogo analoga éndogennykh opioidov dalargina.