Inhibitory effect of sulfamonomethoxine on capsule formation of Bordetella bronchiseptica.
Bordetella bronchiseptica phase I organism possesses a capsule and has the ability to agglutinate with K antiserum, although phase III organism lacks both. The present study examines the effect of sulfamonomethoxine (SMMX) on capsule formation of B. bronchiseptica. I also investigated whether or not the organisms possessed a capsule by bacterial agglutination with K antiserum. Three SMMX-resistant strains of B. bronchiseptica phase I organisms showed loss of agglutinability with K antiserum by culturing them at a higher concentration of 1.56 micrograms/ml of SMMX. These results indicated that capsule formation of SMMX-resistant B. bronchiseptica is inhibited by SMMX.
Kuwano
A
A
Research Institute of Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
D000372:Agglutination Tests; D000818:Animals; D016667:Bacterial Capsules / Q000187:drug effects*; D001885:Bordetella Infections / Q000382:microbiology / Q000662:veterinary; D016950:Bordetella bronchiseptica / Q000187:drug effects*; D012222:Rhinitis, Atrophic / Q000382:microbiology / Q000662:veterinary; D013422:Sulfamonomethoxine / Q000494:pharmacology*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology
D013422:Sulfamonomethoxine