Transcranial Doppler (TCD) after nitroglycerin in migraine without aura.
Nitroglycerin, a vasodilating agent, was administered sublingually in migraine without aura patients and in healthy volunteers. Systolic, diastolic and time-mean flow velocity and pulsatility index, were measured by transcranial Doppler sonography in the major intracranial arteries before and after nitroglycerin administration. Following nitroglycerin administration, a significant decrease in systolic and time-mean velocity and pulsatility index was observed in migraine patients, whereas in control subjects only time-mean velocity decreased significantly. Based on those findings we hypothesize a more marked responsiveness to nitroglycerin in migraine patients as compared to healthy subjects.
Zanette
E M
EM
Department of Neurological Sciences, University La Sapienza, Rome, Italy.
Agnoli
A
A
Cerbo
R
R
Chiarotti
F
F
Roberti
C
C
Buzzi
M G
MG
Fieschi
C
C
D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D003971:Diastole / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005996:Nitroglycerin / Q000494:pharmacology*; D011673:Pulsatile Flow / Q000187:drug effects; D011674:Pulse / Q000187:drug effects; D013599:Systole / Q000187:drug effects; D014463:Ultrasonography
D005996:Nitroglycerin