title: [Streptokinase as routine treatment in acute myocardial infarction. The effect on pain, arrhythmias and mortality assessed by a historical cohort study].
abstract: It has been demonstrated that treatment with streptokinase (SK) in acute myocardial infarction (AMI) has an effect in reducing the mortality. The object of this study was, by means of a historical cohort study in a Danish Cardiological Department, to illustrate the effect of streptokinase on the course of pain, occurrence of arrhythmia and the lethality. Seventy-six patients with their first AMI treated with SK and low-dosage acetylsalicylic acid were compared with 76 patients with their first AMI who were not treated with SK. The median value of the employment of intravenous analgesics was significantly lower in the SK group (20 mg nicomorphine compared with 41 mg nicomorphine) as compared with the control group. Similarly, the duration of pain was briefer in the SK group (3.5 hours compared with 24 hours). Significantly more patients in the control group developed atrial fibrillation (12 patients compared with two). No differences were observed in the occurrence of arrhythmias endangering life in the two groups. Four patients in the SK group died during hospitalization whereas 14 died in the control group (p = 0.02). It is concluded that administration of SK intravenously combined with low-dosage acetylsalicylic acid in the acute phase of myocardial infarction has the effect of reducing 1) the duration of pain and thus the consumption of analgesics, 2) the number of cases of atrial fibrillation and 3) the lethality during the period of hospitalization.
authors.affiliation: Kardiologisk afdeling S, Aalborg Sygehus, Syd.
authors.forename: J H
authors.initials: JH
authors.lastname: Christensen
authors.forename: H T
authors.initials: HT
authors.lastname: Sørensen
authors.forename: F E
authors.initials: FE
authors.lastname: Nielsen
authors.forename: L
authors.initials: L
authors.lastname: Ravn
authors.forename: S E
authors.initials: SE
authors.lastname: Rasmussen
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy / Q000209:etiology; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology; D001281:Atrial Fibrillation / Q000209:etiology / Q000517:prevention & control; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D013300:Streptokinase / Q000627:therapeutic use*
chemical_list: D013300:Streptokinase
vernacular_title: Streptokinase som rutinebehandling ved akut myokardieinfarkt. Effekten på smerter, arytmier og letalitet vurderet ud fra en historisk kohorteundersøgelse.