Vitamin D suppression of spleen colony formation in radiation chimeras.
The effect of vitamin D on spleen colonies in murine bone marrow chimeras was investigated using a single suprapharmacologic dose of vitamin D. The results revealed that vitamin D even without producing hypercalcemia, reduced to a significant degree the number of spleen colonies obtained. This finding is thought to be due to either a direct effect of the vitamin on the capacity of stem cells to multiply or an effect on the number of stem cells that lodge in the spleen.
Nuwayri-Salti
N
N
Department of Human Morphology, American University of Beirut, Faculty of Medicine, New York, N.Y.
Abdel-Halim
J
J
Salem
Z
Z
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011828:Radiation Chimera; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D014807:Vitamin D / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D014807:Vitamin D