title: Effect of erythroid differentiation factor on megakaryocytic differentiation of L8057, a murine megakaryoblastic leukemia cell line.
abstract: To assess the potent effect of erythroid differentiation factor (EDF) on megakaryocytopoiesis, effect of EDF on megakaryocytic differentiation of L8057, a murine megakaryoblastic cell line, was examined. EDF potentiated AchE induction of L8057 in a dose dependent manner. The potency of EDF on megakaryocytic differentiation is comparable to that on erythroid differentiation reported previously. The present results suggest that EDF may play a regulatory role in megakaryocytopoiesis as well as in erythropoiesis.
authors.affiliation: Department of Pediatrics, Yokohama City University, School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Kaku
authors.forename: Y
authors.initials: Y
authors.lastname: Azuno
authors.forename: K
authors.initials: K
authors.lastname: Okafuji
authors.forename: Y
authors.initials: Y
authors.lastname: Etoh
authors.forename: M
authors.initials: M
authors.lastname: Shiozaki
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D028341:Activins; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D007265:Inhibins / Q000494:pharmacology*; D007700:Kinetics; D007942:Leukemia, Experimental; D008533:Megakaryocytes / Q000166:cytology* / Q000187:drug effects; D051379:Mice; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D028341:Activins; D007265:Inhibins; D000110:Acetylcholinesterase; D013755:Tetradecanoylphorbol Acetate