Interaction between carbamazepine and fluvoxamine.
In 3 patients the addition of fluvoxamine to a constant dosage of carbamazepine (CZP) caused a substantial rise of plasma CZP accompanied by symptoms of intoxication. As this drug combination may occur increasingly in the future, this probably pharmacokinetic interaction is of practical relevance.
Fritze
J
J
Department of Psychiatry, University of Würzburg, Germany.
Unsorg
B
B
Lanczik
M
M
D000328:Adult; D001883:Borderline Personality Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D002220:Carbamazepine / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004829:Epilepsy, Generalized / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D016666:Fluvoxamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009325:Nausea / Q000097:blood / Q000139:chemically induced; D014839:Vomiting / Q000097:blood / Q000139:chemically induced
D002220:Carbamazepine; D016666:Fluvoxamine