title: 13,14-dihydro-PGE1, an in-vivo metabolite of PGE1, decreases mitotic activity induced by corticosteroid administration.
abstract: PGE1 has antimitotic activity by virtue of its effect in increasing cAMP in vascular smooth muscle cells. The present study compares the effect of 13,14-dihydro-PGE1 (13,14-DH-PGE1) with PGE1 in an experimental model of stress induced by desoxycorticosterone in the rabbit. 13,14-DH-PGE1 significantly inhibited the stress-induced increase in mitotic activity, measured by autoradiography as percentage of 3H-thymidine positive cells, in all 3 abdominal aortic wall layers. Administration prior to stress was more effective than after stress, while combined administration was most effective. 13,14-DH-PGE1 exerts approximately 90% of the antimitotic activity of PGE1. It seems possible that the antimitotic activity observed after administration of intravenous PGE1 is attributable in part to 13,14-DH-PGE1.
authors.affiliation: 2nd Department of Internal Medicine, Policlinic Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Fitscha
authors.forename: F
authors.initials: F
authors.lastname: Rauscha
authors.forename: W
authors.initials: W
authors.lastname: Rogatti
authors.forename: B A
authors.initials: BA
authors.lastname: Peskar
authors.forename: J
authors.initials: J
authors.lastname: O'Grady
authors.forename: H
authors.initials: H
authors.lastname: Sinzinger
mesh_terms: D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001012:Aorta, Abdominal / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D003900:Desoxycorticosterone / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects*; D011817:Rabbits; D013312:Stress, Physiological / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D013936:Thymidine / Q000378:metabolism
chemical_list: C069881:13,14-dihydroprostaglandin E1; D003900:Desoxycorticosterone; D000527:Alprostadil; D013936:Thymidine