title: [Influence of recombinant interleukin-2 on the course and pathomorphology of intraperitoneal staphylococcal infection in mice].
abstract: Resistance to the lethal doses of the infectious agent (3 DL100) develops in mice 6 days after the intraperitoneal non-lethal dose of staphylococcus in combination with recombinant interleukin-2 (RIL-2). This effect may be due to the activation of T- and B-dependent zones of the regional lymph nodes and spleen, activation and proliferation of the liver stellate reticulo-endotheliocytes, enhancement of the phagocytic activity of the circulating neutrophil granulocytes. These structural and functional mechanisms may be due to both direct RIL-2 effect in combination with an antigenic stimulation and indirect effect through other interleukins produced by lymphocytes activated by RIL-2.
authors.forename: O Ia
authors.initials: OIa
authors.lastname: Kaufman
authors.forename: S N
authors.initials: SN
authors.lastname: Bykovskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Shadrin
authors.forename: B V
authors.initials: BV
authors.lastname: Shlopov
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005260:Female; D007274:Injections, Intraperitoneal; D007376:Interleukin-2 / Q000627:therapeutic use*; D008099:Liver / Q000166:cytology / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects; D011994:Recombinant Proteins / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000473:pathology*
chemical_list: D007376:Interleukin-2; D011994:Recombinant Proteins
vernacular_title: Vliianie rekombinantnogo interleĭkina-2 na techenie i patomorfologiiu vnutribriushnoĭ stafilokokkovoĭ infektsii mysheĭ.