Studies on low molecular weight nuclear protein of tumour and normal cells.
1. Preliminary results of comparative electrophoretical and immunological analyses of the components of two classes of non-histone proteins, i.e. NHP1 and NHP2 eluted from hydroxyapatite allowed to suppose that protein of Mw 18,000 is specific for animal tumour cells. 2. However, the studies on cellular distribution of this polypeptide indicated that it is exclusively located in nuclei of hepatoma and normal liver as well. 3. The former observation seems to be the result of changes of the affinity of this protein to DNA during neoplastic transformation.
Lipińska
A
A
Department of Cytobiochemistry, University of Lódź, Poland.
Krajewska
W M
WM
Marszałek
M
M
Kiliańska
Z
Z
Kłyszejko-Stefanowicz
L
L
D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry / Q000378:metabolism*; D006224:Cricetinae; D004591:Electrophoresis, Polyacrylamide Gel; D015151:Immunoblotting; D008099:Liver / Q000737:chemistry*; D008113:Liver Neoplasms / Q000737:chemistry*; D008114:Liver Neoplasms, Experimental / Q000737:chemistry*; D008970:Molecular Weight; D051381:Rats; D014407:Tumor Cells, Cultured
D002868:Chromosomal Proteins, Non-Histone