Effect of monosodium glutamate on cell-mediated immunity.
Cell-mediated immunity was investigated in adult mice and rats treated with monosodium glutamate in their suckling period. Delayed-type hypersensitivity to xenogeneic cells and host-versus-graft reactivity to allogeneic cells were depressed in these mice. Their splenocytes showed reduced mitogen-induced blastogenesis in vitro which was restored by removal of nonadherent to glass spleen cells. Xenogeneic local graft-versus-host reaction induced by spleen cells taken from Wistar rats treated with monosodium glutamate was significantly decreased. Treatment with monosodium glutamate of neonatal mice and rats (possibly producing hypothalamic lesions) significantly reduced their cell-mediated immunity.
Kubera
M
M
Laboratory of Immunobiology, Polish Academy of Sciences, Kraków.
Bubak-Satora
M
M
Skowron-Cendrzak
A
A
Mazur-Kolecka
B
B
Stĕdra
J
J
Holán
V
V
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001835:Body Weight / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects; D006968:Hypersensitivity, Delayed; D007031:Hypothalamus / Q000502:physiology; D007111:Immunity, Cellular / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D051381:Rats; D011919:Rats, Inbred Strains; D012970:Sodium Glutamate / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology; D013936:Thymidine / Q000378:metabolism
D003208:Concanavalin A; D013936:Thymidine; D012970:Sodium Glutamate