Strain differences in convulsive response to the excitotoxin kainic acid.
We describe a strain of rats (Wistar-Furth) that is highly susceptible to the neurotoxic effects of kainic acid (KA) and presents a reliable and quantifiable (with low within-group variability) animal model of status epilepticus. Wistar-Furth rats are more sensitive and demonstrate a less variable convulsant response than Sprague-Dawley and Long-Evans rats when tested for total time in seizure activity, latency to onset of first seizure, latency to status epilepticus, seizure severity scores, and percentage exhibiting behavioral seizures and status epilepticus. Results suggest that significant heterogeneity exists in the rodent population with regard to neuronal sensitivity to an excitotoxic amino acid and indicate that strain differences are an important consideration in studies using KA.
Golden
G T
GT
Research and Neurology Service, Department of Veterans Affairs Medical Center, Coatesville, PA 19320.
Smith
G G
GG
Ferraro
T N
TN
Reyes
P F
PF
Kulp
J K
JK
Fariello
R G
RG
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D007608:Kainic Acid; D009498:Neurotoxins; D051381:Rats; D011919:Rats, Inbred Strains; D011920:Rats, Inbred WF; D012640:Seizures / Q000139:chemically induced*; D013226:Status Epilepticus / Q000139:chemically induced
D009498:Neurotoxins; D007608:Kainic Acid