[The antihyperalgesic and selective analgesic effects of neurotropin].
In experiments of albino rats neurotropin injection was shown to increase the latency of the tail-flick test in response to the nociceptive thermal stimulus and didn't change the threshold of the test in response to the nociceptive electroskin stimulus. The administration of the antiserum to beta-endorphin lowered the threshold and the latency of the tail-flick test in response to both stimuli. The preliminary administration of neurotropin reduced the hyperalgesic effect of the antiserum on both nociceptive stimuli.
Litvinova
S V
SV
Aristova
V V
VV
Kaliuzhnyĭ
A L
AL
Shul'govskiĭ
V V
VV
Kaliuzhnyĭ
L V
LV
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation / Q000379:methods; D006358:Hot Temperature; D006930:Hyperalgesia / Q000188:drug therapy* / Q000209:etiology; D007106:Immune Sera / Q000008:administration & dosage; D010146:Pain / Q000188:drug therapy; D011134:Polysaccharides / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects; D013997:Time Factors; D001615:beta-Endorphin / Q000276:immunology
D000700:Analgesics; D007106:Immune Sera; D011134:Polysaccharides; C010491:neurotropin; D001615:beta-Endorphin
Antigiperal'geticheskiĭ i izbiratel'nyĭ anal'geticheskiĭ éffekty neĭrotropina.