title: Analgesia in tonsillectomy: a double-blind study on pre and post-operative treatment with diclofenac.
abstract: The efficacy and tolerability of diclofenac suppositories given pre and/or post-operatively were investigated in a randomized double-blind study on 99 patients undergoing tonsillectomy. In one group, 50 mg diclofenac was given 1 h preoperatively, followed by 50 mg directly after the operation. In another group, diclofenac 100 mg was given only immediately post-operatively. A significantly lower consumption of rescue analgesics (paracetamol and/or pethidine) was found in the group treated preoperatively with diclofenac and the average time until first demand of rescue analgesics was significantly longer compared to the group given diclofenac post-operatively only. The tolerance was good and no serious bleeding complications occurred in either group. In the treatment of post-operative pain after tonsillectomy, the combination of pre and post-operative administration of diclofenac suppositories resulted in significantly lower consumption of rescue analgesics and is thus preferable to administration solely post-operatively.
authors.affiliation: ENT Department, Växjö Central Hospital, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Nordbladh
authors.forename: B
authors.initials: B
authors.lastname: Ohlander
authors.forename: R
authors.initials: R
authors.lastname: Björkman
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000698:Analgesia; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008614:Meperidine / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*; D010919:Placebos; D011182:Postoperative Care; D011292:Premedication; D013488:Suppositories; D014068:Tonsillectomy / Q000009:adverse effects
chemical_list: D010919:Placebos; D013488:Suppositories; D004008:Diclofenac; D000082:Acetaminophen; D008614:Meperidine