Effect of captopril on aldosterone response to potassium infusion in primary aldosteronism.
The effect of captopril on the aldosterone response to potassium was studied in 6 patients with idiopathic adrenal hyperplasia (IAH) and in 4 patients with an aldosterone-producing adenoma (APA), who all have suppressed activity of circulating renin-angiotensin system (RAS). Precaptopril, KCl infusion induced a significant increase in aldosterone in both groups. This increment was significantly blunted by captopril in IAH, but not in APA. Decreased potassium-stimulated aldosterone secretion after captopril in IAH supports the hypothesis that adrenal RAS plays a role in aldosterone production under potassium stimulation.
Fallo
F
F
Institute of Semeiotica Medica, University of Padova, Italy.
Chouman
M
M
Pagotto
U
U
Pistorello
M
M
D000236:Adenoma / Q000097:blood; D000310:Adrenal Gland Neoplasms / Q000097:blood; D000311:Adrenal Glands / Q000473:pathology; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000097:blood; D002216:Captopril / Q000494:pharmacology*; D005260:Female; D005410:Flame Ionization; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood*; D006965:Hyperplasia; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011189:Potassium Chloride / Q000494:pharmacology*; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood
D000804:Angiotensin II; D000450:Aldosterone; D011189:Potassium Chloride; D002216:Captopril; D012083:Renin; D011188:Potassium