Lung injury in acute experimental pancreatitis in rats. II. Functional studies.
In this study we report the functional changes in isolated perfused lungs from rats with cerulein-induced experimental pancreatitis. Rat lungs isolated immediately after the cerulein infusion demonstrated decreased pressor responses to angiotensin II (A II) and acute hypoxia (FIO2: 0.0). The lung wet- to dry-weight ratio was increased, as was the lung-leak index, consistent with high-permeability edema formation in the lung. Neither saline-solution infusion for 12 h nor perfusion with cerulein of rat lungs isolated from untreated animals caused lung injury or functional alterations. The changes in pulmonary vascular reactivity were normalized 48-72 h after induction of pancreatitis. In conclusion, we describe an animal model of pancreatitis and reversible, ARDS-like lung injury.
Feddersen
C O
CO
Department of Internal Medicine, Philipps-University Marburg, FRG.
Willemer
S
S
Karges
W
W
Püchner
A
A
Adler
G
G
Wichert
P V
PV
D000208:Acute Disease; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002199:Capillary Permeability; D002108:Ceruletide; D000860:Hypoxia; D008168:Lung / Q000098:blood supply / Q000503:physiopathology*; D008297:Male; D009929:Organ Size; D010195:Pancreatitis / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000503:physiopathology; D014655:Vascular Resistance; D014661:Vasoconstriction
D000804:Angiotensin II; D002108:Ceruletide