A study on the chronopharmacokinetics of theophylline in rabbits.
The Chronopharmacokinetics of a single oral dose of theophylline was studied in rabbits. It was observed that morning (06.00 hr) dosing was characterized by significantly low rate of absorption (t 1/2a and Tmax) but higher extent of absorption (AUC0-alpha) compared to that after nocturnal dosing (22.00 hr). The plasma half life (t1/2el) was significantly less at night compared to that in daytime. The data may have considerable clinical relevance.
Kumar
A
A
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Chakrabarti
A
A
Garg
S K
SK
D000284:Administration, Oral; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D002940:Circadian Rhythm / Q000502:physiology*; D004334:Drug Administration Schedule; D008297:Male; D011817:Rabbits; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*
D013806:Theophylline