title: Calculation of efficacy of acellular pertussis vaccine from the number of pertussis patients and vaccinees in three areas.
abstract: A study is presented of the efficacy of acellular pertussis vaccine based on the number of pertussis patients and its relationship to vaccination rate in three demographic areas of Osaka Prefecture, Japan. In three separate areas within Osaka Prefecture, the pertussis vaccine is given to children three to six months of age, and in the other two it is given to children two years of age or older. Use of a mathematical method to correct the reported number of pertussis patients per 100,000 population with a constant obtained from analysis of the reported number of exanthem subitum cases allowed us to compare the number of pertussis patients in the three areas with each other. Vaccination rate by age and incidence of pertussis in each city revealed the efficacy of acellular pertussis vaccine to be 94.8%.
authors.affiliation: Osaka Infectious Center, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ohkuni
authors.forename: M
authors.initials: M
authors.lastname: Yabiku
authors.forename: M
authors.initials: M
authors.lastname: Togawa
authors.forename: K
authors.initials: K
authors.lastname: Fukai
authors.forename: I
authors.initials: I
authors.lastname: Yosida
authors.forename: Y
authors.initials: Y
authors.lastname: Minekawa
authors.forename: T
authors.initials: T
authors.lastname: Kitamura
mesh_terms: D000367:Age Factors; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D014917:Whooping Cough / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D010567:Pertussis Vaccine