Potential clinical use of an adrenergic/cholinergic agent (HP 128) in the treatment of Alzheimer's disease.
A novel compound designated HP 128, which manifests adrenergic and cholinergic properties, was administered for 10 days to patients with Alzheimer's disease in a double-blind, placebo-controlled trial. All patients who entered the trial had previously failed to respond to a structurally related cholinesterase inhibitor without adrenergic properties (HP 029). The primary purpose of the study was to assess the safety and tolerance of HP 128. Efficacy measures were obtained to generate hypotheses for possible future studies. In the dosage range examined, HP 128 was safe and well tolerated. Effects on clinical measures of dementia severity were equivocal.
Huff
F J
FJ
Clinical Neuroscience Research, Hoechst-Roussel Pharmaceuticals, Inc. Somerville, New Jersey 08876.
Antuono
P
P
Murphy
M
M
Beyer
J
J
Dobson
C
C
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000188:drug therapy*; D000609:Aminoacridines / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos
D000609:Aminoacridines; D010919:Placebos; C070061:suronacrine