Interactive effect of ethanol administration on blood propranolol levels in rats.
Effect of ethanol administration on blood propranolol concentration (BPC) was investigated with rats. By oral administration of 20 mg/kg propranolol hydrochloride together with 1.5 g/kg of ethanol, it was suggested that there might be an increase in blood 4-hydroxypropranolol concentration (BHPC) though BPC did not increase. By oral administration of propranolol 3 hours after oral administration of 1.0 g/kg ethanol, it was suggested that both BPC and BHPC might increase. It was considered that the main mechanisms of increases in BPC and BHPC by ethanol were a rise of intestinal permeability to propranolol and an inhibition of 4-hydroxypropranolol metabolism in hepatic microsomes, respectively.
Moriya
F
F
Department of Legal Medicine, Okayama University Medical School.
Ishizu
H
H
D000284:Administration, Oral; D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D011433:Propranolol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood* / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains
C001422:4-hydroxypropranolol; D000431:Ethanol; D011433:Propranolol