Scanning electron microscopy of ovine endothelial cells in vitro exposed to tunicamycin.
The endothelium of isolated ovine aorta was severely damaged when exposed to tunicamycin. This observation supports the hypothesis that endothelial injury is the basis of the neural lesions induced by this toxin in livestock.
Finnie
J W
JW
S.A. Department of Agriculture, Central Veterinary Laboratories, Adelaide.
D000818:Animals; D001011:Aorta / Q000166:cytology; D002545:Brain Ischemia / Q000139:chemically induced / Q000662:veterinary*; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D006017:Glycolipids / Q000633:toxicity; D008855:Microscopy, Electron, Scanning; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced*; D013329:Structure-Activity Relationship; D014415:Tunicamycin / Q000494:pharmacology*
D006017:Glycolipids; C034696:corynetoxins; D014415:Tunicamycin