Hematogenous dissemination of Mycobacterium tuberculosis in patients with AIDS.
Proof of hematogenous dissemination of Mycobacterium tuberculosis was initially reported in the early 1900s and was noted to be most frequent in patients with miliary tuberculosis. More recently, M. tuberculosis bacteremia has been reported in human immunodeficiency virus (HIV)-infected patients. We describe 13 adult HIV-infected patients in whom hematogenous M. tuberculosis dissemination was evident. Although for most patients whose bone marrow aspirate cultures yielded M. tuberculosis a chest roentgenogram revealed a miliary pattern, roentgenograms for those with M. tuberculosis bacteremia usually revealed evidence of lobar or diffuse infiltrates. Most patients with M. tuberculosis bacteremia had other risk factors for M. tuberculosis, and many had a rapid death, suggesting acute fulminant infection. Our own experience suggests that there are various syndromes associated with hematogenous dissemination in patients infected with M. tuberculosis.
Clark
R A
RA
Tulane/LSU AIDS Clinical Trial Unit, Tulane University Medical Center, New Orleans, Louisiana 70112.
Blakley
S L
SL
Greer
D
D
Smith
M H
MH
Brandon
W
W
Wisniewski
T L
TL
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D016470:Bacteremia / Q000150:complications*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications; D011020:Pneumonia, Pneumocystis / Q000150:complications; D011859:Radiography; D012189:Retrospective Studies; D012307:Risk Factors; D014376:Tuberculosis / Q000150:complications* / Q000000981:diagnostic imaging