title: [The biological availability of cefadroxil given simultaneously with N-acetylcysteine].
abstract: A preliminary study revealed that similarly to the antibiotics amoxillin, thiamphenicol, erythromycin and doxycycline, the oral cephalosporin cefadroxil (CAS 66592-87-8) can be administered simultaneously with the mucolytic n-acetylcysteine (CAS 616-91-1). In the present study 12 healthy male volunteers received in a randomised cross-over design a single oral dose of 1000 mg cefadroxil or a single oral dose of 1000 mg cefadroxil (Bidocef) plus 200 mg n-acetylcysteine. The two study days were separated by a wash-out period of one week. To determine the pharmacokinetic profile of cefadroxil, plasma and sputum were analysed by HPLC at defined intervals. Regarding the bioavailability of cefadroxil, the free combination is bioequivalent to the individual component. After administration of cefadroxil plus n-acetylcysteine, a higher cefadroxil concentration was found in the sputum compared to an administration of cefadroxil alone. However, the difference was not statistically significant. According to the results, simultaneous administration of the oral cephalosporin cefadroxil and the mucolytic n-acetylcysteine is possible without changes in the bioavailability of cefadroxil being observed.
authors.affiliation: Iphar-CRF Institut für Klinische Pharmakologie GmbHa, München.
authors.forename: M F
authors.initials: MF
authors.lastname: Barkworth
authors.forename: B
authors.initials: B
authors.lastname: Mangold
authors.forename: K D
authors.initials: KD
authors.lastname: Rehm
authors.forename: G
authors.initials: G
authors.lastname: Schmieder
authors.forename: H
authors.initials: H
authors.lastname: Töberich
authors.forename: A
authors.initials: A
authors.lastname: Vinchenzo
authors.forename: J
authors.initials: J
authors.lastname: Weber
authors.forename: C
authors.initials: C
authors.lastname: Rübartsch
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D000328:Adult; D001682:Biological Availability; D002434:Cefadroxil / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D006801:Humans; D008297:Male; D011897:Random Allocation; D013183:Sputum / Q000378:metabolism
chemical_list: D002434:Cefadroxil; D000111:Acetylcysteine
vernacular_title: Ermittlung der Bioverfügbarkeit von Cefadroxil bei gleichzeitiger Gabe von N-Acetylcystein.