title: [A case of Crow-Fukase syndrome with increased serum interleukin-6].
abstract: We experienced a 47-year-old Japanese female with polyneuropathy, edema, hypertrichosis, hyperpigmentation, and white nail, which were diagnostic as having Crow-Fukase syndrome. Laboratory and radiological evaluation showed neither plasma cell dyscrasia nor monoclonal gammopathy. Increased factor VIII activity and thrombocytosis, which suggested thrombotic tendency, were observed at the exacerbation of clinical symptoms. In her third exacerbation, she presented marked cyanosis in her right foot, and angiography confirmed narrowing of arteries at the ankle. Increased serum interleukin-6 was also observed, and the production of interleukin-6 by endothelial cells of cutaneous angioma was shown. Possible role of interleukin-6 in Crow-Fukase syndrome was discussed.
authors.affiliation: Department of Neurology, Japanese Red Cross Medical Center.
authors.forename: S
authors.initials: S
authors.lastname: Hitoshi
authors.forename: H
authors.initials: H
authors.lastname: Okazawa
authors.forename: J
authors.initials: J
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Sakuta
mesh_terms: D005169:Factor VIII / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000150:complications; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood*; D008875:Middle Aged; D016878:POEMS Syndrome / Q000097:blood* / Q000209:etiology; D010976:Platelet Count; D012878:Skin Neoplasms / Q000150:complications; D013927:Thrombosis / Q000097:blood / Q000209:etiology
chemical_list: D015850:Interleukin-6; D005169:Factor VIII