title: Cytokine production by mast cells and basophils.
abstract: Mast cells and/or basophils have been implicated in the expression of a wide variety of biological responses, including immediate hypersensitivity reactions, host responses to parasites and neoplasms, angiogenesis, tissue remodeling, and immunologically non-specific inflammatory and fibrotic conditions. Recent findings suggest that an important mechanism by which mast cells influence such biological responses is through the production of a broad panel of multifunctional cytokines. In contrast, the extent to which basophils can produce cytokines is uncertain.
authors.affiliation: Beth Israel Hospital, Boston, Massachusetts.
authors.forename: S J
authors.initials: SJ
authors.lastname: Galli
authors.forename: J R
authors.initials: JR
authors.lastname: Gordon
authors.forename: B K
authors.initials: BK
authors.lastname: Wershil
mesh_terms: D000818:Animals; D001491:Basophils / Q000276:immunology / Q000378:metabolism*; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism*; D051379:Mice
chemical_list: D016207:Cytokines