title: [The effect of interferon preparations on the ultrastructural organization of Legionella pneumophila].
abstract: The influence of the preparations of interferon on morphological changes in L. pneumophila on the ultrastructural level has been studied. Disturbances in the ultrastructure of L. pneumophila result from the direct bactericidal action of interferons without any interference of immune mechanisms. These disturbances are manifested by damages in the cell wall, plasma membrane, nuclear and ribosomal apparatuses of microbial cells. Leukinferon exhibits pronounced anti-Legionella activity, both in vitro in a liquid culture medium and in ovo, than reaferon.
authors.forename: L V
authors.initials: LV
authors.lastname: Nebozhina
authors.forename: N V
authors.initials: NV
authors.lastname: Klitsunova
authors.forename: I S
authors.initials: IS
authors.lastname: Tartakovskiĭ
authors.forename: V P
authors.initials: VP
authors.lastname: Kuznetsov
authors.forename: A F
authors.initials: AF
authors.lastname: Bykovskiĭ
mesh_terms: D000818:Animals; D002642:Chick Embryo; D003470:Culture Media; D016207:Cytokines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D007370:Interferon Type I / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D016952:Legionella pneumophila / Q000187:drug effects* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011994:Recombinant Proteins
chemical_list: D003470:Culture Media; D016207:Cytokines; D004338:Drug Combinations; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; C062252:leukinferon
vernacular_title: Vliianie preparatov interferona na ul'trastrukturnuiu organizatsiiu Legionella pneumophila.