[New concepts of the course of cholesteatoma from the immunohistological study of 96 samples].
The immunohistological characteristics of retraction pockets, cholesteatoma matrix and granulomatous tissue have been compared. Langerhans cells, epidemic folds and sub-epithelial tissue were labelled with specific markers (HLA II, adhesion receptors, KI 67). The junction between epidermis and sub-epithelial tissue of middle ear mucosa appeared as the most inflammatory area, displaying characteristics of delayed type hypersensitivity phenomenon. CD1+ Langerhans cells appear to express class II molecules only in the vicinity of polymorphonuclear infiltrates. Epidemic proliferation seems to able place mainly in the deepest recesses of the epidermis.
Mayot
D
D
Clinique ORL, CHRU de Nancy-Brabois, Vandoeuvre-les-nancy.
Bene
M C
MC
Perrin
C
C
Faure
G C
GC
Wayoff
M
M
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002781:Cholesteatoma / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D002908:Chronic Disease; D004427:Ear Diseases / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D004432:Ear, Middle; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D008875:Middle Aged; D013997:Time Factors
Nouvelles conceptions de l'évolution du cholestéatome à partir de l'étude immuno-histologique de 96 prélèvements.