Computer software for the on-line measurement of the left ventricular end-systolic pressure-dimension relationship.
A microcomputer system was designed to measure the end-systolic pressure-dimension relationship (ESPDR), an index of cardiac contractility that is independent of preload, afterload, and heart rate. To test the system, pressure-dimension data were obtained from swine left ventricles and from a mathematical model of the heart. Algorithms for filtering, location of end-systole, selection of the measurement interval, and calculation of the ESPDR were evaluated on the basis of speed, precision, accuracy, and robustness. The resulting program runs on an IBM-AT and measures ESPDR on-line within 60 seconds of the start of data acquisition. By reducing the time spent in data analysis and providing rapid feedback of information, the on-line software has increased productivity and facilitated improvements in experimental technique.
Ward
J A
JA
Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200.
Kingsley
C P
CP
Silverman
S M
SM
D000465:Algorithms; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D008838:Microcomputers; D009862:Online Systems; D012984:Software; D013318:Stroke Volume / Q000502:physiology*; D013552:Swine; D016277:Ventricular Function, Left / Q000502:physiology*