[Effect of splenectomy on the development of neonatal lymphoid organs transplanted to animals of varying age].
The effect of splenectomy on the development of newborn thymus and spleen grafted under the kidney capsule of young and old mice has been investigated. Preliminary splenectomy is shown to increase cell counts in grafted spleen that is more conspicuous in young recipients as compared with old ones. This result suggests a decrease with age in the inhibitory effect of the host spleen on the maturation of spleen grafted from newborn donor. Combined transplantation of newborn thymus and spleen has revealed a decrease of cell counts in the donor spleen grafted to the young splenectomized recipients and, on the contrary, increase of this parameter in old ones. Immune response in donor spleen with combined transplantation of the thymus to the old splenectomized recipients is much higher as compared with the same parameter in recipient without splenectomy. It is concluded that partial destruction of the old immune system is essential for its correction.
Butenko
G M
GM
Kharazi
A I
AI
Pishel'
I N
IN
D000375:Aging / Q000276:immunology*; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D002452:Cell Count; D007668:Kidney; D013154:Spleen / Q000276:immunology / Q000637:transplantation*; D013156:Splenectomy; D013950:Thymus Gland / Q000637:transplantation*; D016042:Transplantation, Heterotopic
Vliianie splenéktomii na razvitie limfoidnykh organov novorozhdennykh, peresazhennykh zhivotnym raznogo vozrasta.