Lung adenoma structure among inbred strains of mice: the pulmonary adenoma histologic type (Pah) genes.
Urethane-induced, lung adenoma multiplicity and histologic type vary among mouse strains. We asked whether the Pas genes which control multiplicity also determine adenoma structure. Lung adenomas from inbred mice, F1 hybrids, and recombinant inbred mice were classified by growth pattern as either solid or papillary. Since no correlation was observed between adenoma multiplicity and histologic type, no linkage apparently exists between the Pas genes and adenoma morphology. We propose the name Pah (Pulmonary Adenoma Histologic type) for the genes controlling lung adenoma growth patterns. Genetic analysis indicated dominance of the papillary phenotype, and that two or more Pah genes determine adenoma structure.
Thaete
L G
LG
Colorado Cancer Center, School of Pharmacy, University of Colorado, Boulder 80309-0297.
Nesbitt
M N
MN
Malkinson
A M
AM
D000236:Adenoma / Q000235:genetics* / Q000473:pathology; D000818:Animals; D003537:Cystadenoma / Q000473:pathology; D005260:Female; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains / Q000235:genetics*; D010641:Phenotype