Mechanism of anergy in AIDS and malnutrition.
Human immunodeficiency virus, the retrovirus associated with acquired immunodeficiency syndrome, is known to deplete CD4+ helper cells and reduce CD8+ cytotoxic cell activity, resulting in impaired cell-mediated immunity and a 'state of anergy'. This leads to dissemination of micro-organisms that are normally held dormant in the host by the cell-mediated immune system. Malnutrition also leads to depletion of CD4+ helper cells and decreases CD8+ cytotoxic cells leading to impaired cell-mediated immunity and 'state of anergy'. Clinical situation can worsen when the two conditions co-exist.
Hegde
H R
HR
Department of Pediatrics, University of Calgary, Alberta, Canada.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D009748:Nutrition Disorders / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D015704:CD4 Antigens; D016827:CD8 Antigens