Experience with liposomal amphotericin B (AmBisome) in cryptococcal meningitis in AIDS.
Three patients with AIDS who had cryptococcal meningitis were treated with liposomal amphotericin B after unsuccessful treatment with fluconazole and conventional amphotericin B. One patient responded but relapsed nine weeks later; he responded to a second course of treatment but again relapsed and subsequently died. Another patient deteriorated despite an improvement in cryptococcal antigen titres. The third patient was found to have culture negative CSF and treatment was therefore stopped. None of the patients suffered any adverse effects and renal function improved in all after conventional amphotericin was stopped and liposomal amphotericin B commenced.
Coker
R J
RJ
Department of Genito-Urinary Medicine, St Mary's Hospital, Paddington, London, UK.
Murphy
S M
SM
Harris
J R
JR
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D004337:Drug Carriers; D006801:Humans; D008081:Liposomes; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy* / Q000209:etiology
D004337:Drug Carriers; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B; D003404:Creatinine