Effect of cisapride on gastric emptying in diabetic patients without gastrointestinal symptoms.
The long-team effects of cisapride on gastric emptying and hormonal interaction in diabetic patients without gastrointestinal symptoms was evaluated. Gastric emptying was determined by the N-acetyl-p-amino-phenol (APAP) method before and after cisapride treatment. Gastric emptying improved significantly, from 5.95 to 8.04 micrograms/ml, after 6 weeks of treatment. Plasma concentrations of immunoreactive insulin (IRI), after 30 and 45 minutes in the gastric emptying test, increased significantly after treatment. It appeared that improvement of gastric emptying after loading with cisapride might be related to improved insulin secretion in diabetic patients without subjective symptoms of gastroparesis.
Kasai
S
S
Department of Internal Medicine, School of Medicine, Tokai University, Kanagawa.
Tanaka
K
K
Machimura
H
H
Takeda
H
H
Kaneshige
H
H
Sakai
H
H
Harasawa
S
S
D000082:Acetaminophen / Q000008:administration & dosage / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D020117:Cisapride; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000627:therapeutic use
D001786:Blood Glucose; D007328:Insulin; D010880:Piperidines; D012702:Serotonin Antagonists; D000082:Acetaminophen; D020117:Cisapride