title: The interactive effects of Type A behavior and hostility on bleeding time thromboxane and prostacyclin formation.
abstract: Sixty-six male university students were classified as Type A or B on the basis of the Structured Interview of Rosenman and as hostile or non-hostile on the basis of the Cook-Medley scale. Vascular production of prostacyclin and platelet thromboxane in response to a standard vessel injury was evaluated. Basal thromboxane production, measured as the primary metabolite, thromboxane B2, in blood oozing from the bleeding-time site, was highest among hostile Type A subjects with significantly lower thromboxane production in hostile Type Bs and all non-hostile groups combined. Following an exercise treadmill test hostile subjects produced more thromboxane than non-hostile ones, and hostile Type As had significantly shorter bleeding times than hostile Type Bs. No significant differences on any measure were observed following a stressful color naming task. The observed interaction of hostility and Type A behavior on bleeding time thromboxane formation links behavior to an adverse aspect of a thrombosis-related parameter thought to be involved in the genesis of cardiovascular disease.
authors.affiliation: Department of Psychology, University of Manitoba, Winnipeg, Canada.
authors.forename: D J
authors.initials: DJ
authors.lastname: Schonwetter
authors.forename: P R
authors.initials: PR
authors.lastname: Dion
authors.forename: A E
authors.initials: AE
authors.lastname: Ready
authors.forename: D G
authors.initials: DG
authors.lastname: Dyck
authors.forename: J M
authors.initials: JM
authors.lastname: Gerrard
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000328:Adult; D001143:Arousal / Q000502:physiology*; D001760:Bleeding Time; D001792:Blood Platelets / Q000378:metabolism; D006791:Hostility; D006801:Humans; D008297:Male; D013929:Thromboxane B2 / Q000097:blood*; D014434:Type A Personality
chemical_list: D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha