title: Developmental neuron-glia interaction: role of the serotonin innervation upon the onset of GABA uptake into the ependymocytes of the rat subcommissural organ.
abstract: The subcommissural organ (SCO) of the rat allows the analysis of neuron-glia interactions, in vivo, during the maturation of the brain. The SCO contains a single glial cell type which receives a homogeneous serotonin (5-HT) innervation. The onset of gamma-aminobutyric acid (GABA) uptake transport into the SCO ependymocytes is dependent on the 5-HT innervation since destruction of this innervation, at birth, or transplantation of newborn rat SCO ependymocytes to the fourth ventricle of adult host rats prevented the appearance of [3H]GABA uptake as visualized by autoradiography.
authors.affiliation: INSERM, Hôpital Neurologique, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Didier-Bazes
authors.forename: L
authors.initials: L
authors.lastname: Chouaf
authors.forename: H
authors.initials: H
authors.lastname: Hardin
authors.forename: M
authors.initials: M
authors.lastname: Aguera
authors.forename: M
authors.initials: M
authors.lastname: Fèvre-Montange
authors.forename: M F
authors.initials: MF
authors.lastname: Belin
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002552:Cerebral Ventricles; D004805:Ependyma / Q000166:cytology / Q000378:metabolism / Q000637:transplantation; D009457:Neuroglia / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013351:Subcommissural Organ / Q000166:cytology / Q000378:metabolism* / Q000637:transplantation; D016042:Transplantation, Heterotopic; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D012701:Serotonin; D005680:gamma-Aminobutyric Acid