Peritoneal fluid interleukin-1 beta and tumor necrosis factor in patients with benign gynecologic disease.
The levels of interleukin 1 beta (IL-1 beta) and tumor necrosis factor (TNF) in peritoneal fluid (PF-IL-1 beta and PF-TNF) and production of IL-1 beta and TNF by peritoneal macrophages were determined in patients with benign gynecologic disease. The level of PF-IL-1 beta was elevated in the acute pelvic inflammatory disease (PID) and stages I and II endometriosis (E I/II) groups compared with the normal pelvis group, but not in the myoma of the uterus, ovarian cyst, and postinflammatory pelvic adhesion groups. The level of PF-TNF was elevated in the PID, EI/II and stages III and IV endometriosis (EIII/IV) groups. There was no correlation between the levels of PF-IL-1 beta and PF-TNF. Neither the level of PF-IL-1 beta nor that of PF-TNF was correlated with the concentration of peritoneal macrophages. Peritoneal macrophages produced IL-1 beta and TNF in vitro in the absence of stimulants. The levels of PF-IL-1 beta and PF-TNF are presumably linked to the activation of peritoneal macrophages.
Mori
H
H
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Sawairi
M
M
Nakagawa
M
M
Itoh
N
N
Wada
K
K
Tamaya
T
T
D000328:Adult; D001202:Ascitic Fluid / Q000276:immunology*; D002452:Cell Count; D016009:Chi-Square Distribution; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000032:analysis* / Q000096:biosynthesis; D008264:Macrophages / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis* / Q000096:biosynthesis
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha