Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit.
The human serine/threonine protein casein kinase II (CK II) contains two distinct catalytic subunits, alpha and alpha 1, which are encoded by different genes. A combination of segregation analysis of rodent-human hybrid cells and chromosomal in situ hybridization have localized the human CK II-alpha DNA sequence to two loci: 11p15.5-p15.4 and 20p13. In contrast, the CK II-alpha' gene has been mapped to chromosome 16 by somatic cell hybrid analysis. Taken together with our previous assignment of the CK II regulatory beta-subunit gene to 6p12-p21, these results indicate that although the products of these genes form a single biological complex, they are encoded on different human chromosomes. Further analysis should determine whether both loci of CK II-alpha are functional, or perhaps one of the two constitutes a pseudogene.
Yang-Feng
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TL
Department of Genetics, Yale University School of Medicine, New Haven, CT 06510.
Zheng
K
K
Kopatz
I
I
Naiman
T
T
Canaani
D
D
D015139:Blotting, Southern; D047388:Casein Kinases; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002885:Chromosomes, Human, Pair 16; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D006822:Hybrid Cells; D011494:Protein Kinases / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D011494:Protein Kinases; D047388:Casein Kinases