title: An antiviral sesquiterpene hydroquinone from the marine sponge Strongylophora hartmani.
abstract: A new sesquiterpene hydroquinone 1, which we call strongylin A, was isolated from the marine sponge Strongylophora hartmani. Its structure was determined through spectroscopic methods, including 2D-13C homonuclear correlation spectroscopy (INADEQUATE). Both 1 and its acetate derivative are active in in vitro assays against the P-388 tumor cell line and influenza strain PR-8.
authors.affiliation: Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Ft. Pierce, FL 34946.
authors.forename: A E
authors.initials: AE
authors.lastname: Wright
authors.forename: S A
authors.initials: SA
authors.lastname: Rueth
authors.forename: S S
authors.initials: SS
authors.lastname: Cross
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification; D002460:Cell Line; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009975:Orthomyxoviridae / Q000187:drug effects; D011161:Porifera; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D012717:Sesquiterpenes; C073085:strongylin A