[Determination of nystatin component composition using HPLC and TLC with densitometry].
The component composition of nystatin produced by an improved strain of Streptomyces noursei was determined by HPLC on Milichrom chromatograph (USSR). It was shown that the antibiotic consisted of nystatins A1, A2, A3 and B and admixture substances. The data appeared to be in good agreement with the results of the complex TLC investigation, by using densitometry. The component composition of the samples was evidenced by SIEAP mass spectrometry. Physiochemical and biological characteristics of separate components are presented.
Mitrofanova
V G
VG
Shenin
Iu D
IuD
Mirgorodskaia
O A
OA
Derzhavets
A A
AA
Matveeva
E R
ER
Grinberg
G E
GE
Apter
Iu M
IuM
Golubkova
L S
LS
D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003720:Densitometry; D009761:Nystatin / Q000032:analysis*
D009761:Nystatin
Opredelenie komponentnogo sostava nistatina metodami VEZhKh i TSKh s ispol'zovaniem densitometrii.