Dithiocarbamate analog N-(4-methoxybenzyl)-N-dithiocarboxy-D-glucamine reduces the retention of ingested cadmium in rats.
This study was performed to evaluate the effect of oral and intraperitoneal treatment with N-(4-methoxybenzyl)-D-glucamine dithiocarbamate monohydrate (MeOBDCG) after a single oral administration of 115mCd to 6-week-old rats. Oral treatment reduced the retention of 115mCd in the whole body, gut, liver and kidney by 5, 3, 4 and 3 times respectively, and intraperitoneal treatment reduced the retention by 7, 2.5, 16 and 4.5 times, respectively. This finding is new, since it was believed that oral dithiocarbamate treatment would increase the toxicity and absorption of ingested cadmium.
Kargacin
B
B
Department of Mineral Metabolism, University of Zagreb, Yugoslavia.
Kostial
K
K
Arezina
R
R
Singh
P K
PK
Jones
M M
MM
Cikrt
M
M
D000284:Administration, Oral; D000818:Animals; D002104:Cadmium / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*; D002614:Chelating Agents / Q000494:pharmacology; D005260:Female; D007274:Injections, Intraperitoneal; D051381:Rats; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000494:pharmacology; D013859:Thiocarbamates / Q000494:pharmacology*
D002614:Chelating Agents; D013859:Thiocarbamates; D002104:Cadmium; C060427:N-(4-methoxybenzyl)glucamine dithiocarbamate; D013012:Sorbitol