title: Urinary hydroxyproline and serum alkaline phosphatase in sickle cell disease.
abstract: Serum alkaline phosphatase, alkaline phosphatase isoenzymes, and urinary hydroxyproline excretion were studied in 20 young adult sickle cell patients and 58 matching normal controls. Total alkaline phosphatase was significantly higher in the sickle cell patients than in controls. Heat inactivation test and isoenzyme electrophoresis indicated that bone is the predominant isoenzyme in patients. Hydroxyproline excretion was significantly higher in the sickle cell patients than in controls. Serum total alkaline phosphatase correlated well with urinary hydroxyproline excretion in sickle cell patients (r = 0.73). Both alkaline phosphatase and hydroxyproline increased with age in the sickle cell patients. This study suggests that delayed growth and/or bone destruction may contribute to the elevated levels of alkaline phosphatase and urinary hydroxyproline.
authors.affiliation: Department of Clinical Biochemistry, College of Medicine, King Saud University, Abha Branch Abha Saudi Arabia.
authors.forename: S M
authors.initials: SM
authors.lastname: Mohammed
authors.forename: S A
authors.initials: SA
authors.lastname: Suleiman
authors.forename: S K
authors.initials: SK
authors.lastname: Addae
authors.forename: S H
authors.initials: SH
authors.lastname: Annobil
authors.forename: F K
authors.initials: FK
authors.lastname: Adzaku
authors.forename: O F
authors.initials: OF
authors.lastname: Kadoummi
authors.forename: J T
authors.initials: JT
authors.lastname: Richards
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000097:blood*; D000755:Anemia, Sickle Cell / Q000378:metabolism*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D012529:Saudi Arabia
chemical_list: D007527:Isoenzymes; D000469:Alkaline Phosphatase; D006909:Hydroxyproline