[In vitro identification of a mononuclear precursor of osteoclast].
Osteoclast is derived from mononuclear hematopoietic stem cells, most likely within the granulocyte-macrophage lineage. The exact differentiation process of osteoclasts precurssors has only been partially uncovered. The authors isolated in vitro, from the medullary bone of hens a mononuclear precursor of the osteoclast. This cell expressed several characteristics of mature and multinucleated osteoclast including the capacity to resorb the extracellular bone matrix.
Prallet
B
B
Laboratoire de Biologie du Tissu Osseux, Université de Médecine, Saint-Etienne.
Alexandre
C
C
Baron
R
R
D000818:Animals; D001862:Bone Resorption; D002454:Cell Differentiation; D002645:Chickens; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D010010:Osteoclasts / Q000648:ultrastructure*
Identification, in vitro, d'un précurseur mononucléé de l'ostéoclaste.