[Effect of dipyridamole on the interrelations of the stromal and hematopoietic tissues of the bone marrow in experimental studies].
By means of heterotopic transplantation of the bone marrow interrelations of the stromal and hemopoietic tissues of the mice bone marrow have been studied at administration of dipiridamol. Effect of the drug to the hemopoiesis is realized via stem stromal cells of the bone marrow. Under the influence of dipiridamol a focus of heterotopic hemopoiesis the osteogenic component in it is present only in 30% of cases in comparison with the control. Inhibition of the stromal component proliferation is accompanied with increasing mitotic activity of the hemopoietic elements against the background of the bone marrow cellularity decrease both in the femoral bone and in the focus of heterotopic hemopoiesis. At administration of dipiridamol a phenomenon of noneffective megakaryocytopoiesis with the intrabone marrow destruction of megakaryocytes, resulting in local release of thrombocyte growth factor, which has a compensatory character.
Ivasenko
I N
IN
Arkad'eva
G E
GE
D000818:Animals; D016026:Bone Marrow Transplantation / Q000502:physiology*; D002452:Cell Count / Q000187:drug effects; D003864:Depression, Chemical; D004176:Dipyridamole / Q000494:pharmacology*; D006411:Hematopoiesis, Extramedullary / Q000187:drug effects / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D007668:Kidney; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D016042:Transplantation, Heterotopic / Q000502:physiology*
D004176:Dipyridamole
Deĭstvie dipiridamola na vzaimootnosheniia stromy i gemopoieticheskoĭ tkani kostnogo mozga v éksperimente.