[The characteristics of the postsplenectomy hyperthrombocytic syndrome in patients with chronic myeloleukemia].
One of the clinical features of chronic myeloid leukemia (CML) after splenectomy lies in the development of an unusual hyperthrombocytic syndrome. In the course of a long-term observation, 12 out of 14 patients subjected to splenectomy demonstrated maximum thrombocytosis ranging from 1.008 X 10(9) to 3.053 X 10(9)/l. Hemorrhagic manifestations occurred in 6 patients, no thromboses were recorded. Postsplenectomy hyperthrombocytosis is to a certain measure resistant to cytostatic therapy. Dissociation may occur--good readings of the leukogram with a high hyperthrombocytosis. According to the authors' and reported data, the postsplenectomy hyperthrombocytic syndrome in ALL patients is fraught with the danger of the occurrence of hemorrhagic manifestations and, to a less degree, of thromboses.
Berliner
T B
TB
Miasnikov
A A
AA
Kheĭfets
L M
LM
Polezhaev
Iu N
IuN
D000328:Adult; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000150:complications* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D013156:Splenectomy; D013577:Syndrome; D013916:Thrombelastography; D013922:Thrombocytosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D013997:Time Factors
Ob osobennostiakh postsplenéktomicheskogo gipertrombotsitarnogo sindroma u bol'nykh khronicheskim mieloleĭkozom.