Toxicity of aldehyde products of lipid peroxidation to adult Schistosoma intercalatum in vitro.
The host's immune response results in oxidative damage to parasite membranes. Known aldehyde breakdown products from lipid peroxidation have been investigated for their in vitro toxicity to Schistosoma intercalatum. Saturated and monounsaturated aldehydes were found to be relatively non-toxic, whilst dienal and hydroxyenal aldehydes had LD50 values in the range of 10-20 microM. Conversion of the toxic aldehydes to their corresponding alcohols or glutathione conjugates reduced toxicity to S. intercalatum by one or two orders of magnitude. This suggests that parasite detoxification enzymes might be useful targets for chemotherapy and raises the possibility of combining chemo- and immunotherapy.
Barrett
J
J
Department of Biological Sciences, University College of Wales, Aberystwyth, Dyfed, U.K.
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D015227:Lipid Peroxidation; D012547:Schistosoma / Q000187:drug effects*
D000447:Aldehydes