6-OHDA lesion to the entorhinal cortex does not abolish angiotensin II improvement of recall in rats.
Our recent studies have shown that facilitating effect of angiotensin II (AII) on recall is mediated by dopaminergic systems. In this study the influence of bilateral destruction of dopaminergic endings in the entorhinal cortex on improving recall intracerebroventricular injection of AII was tested. Since this lesion did not abolish the facilitating influence of AII, it may be suggested that the dopaminergic projection to the entorhinal cortex is not responsible for the facilitating effect of AII on recall in a passive avoidance situation.
Winnicka
M M
MM
Department of Pharmacology, Medical Academy, Białystok, Poland.
Braszko
J J
JJ
Wiśniewski
K
K
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D016627:Oxidopamine / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D000804:Angiotensin II; D016627:Oxidopamine