A rapid method for the determination of cocaine in brain tissue.
A rapid procedure is described for the extraction and analysis of brain samples for cocaine and benzoylecgonine. Human brain tissue was sectioned at autopsy, and samples were subjected to a lipase digestion, subsequent to solid-phase extraction. The distribution of cocaine and benzoylecgonine throughout different regions of the brain was determined by high-performance liquid chromatography.
Browne
S P
SP
Department of Pharmacodynamics, University of Illinois, Chicago.
Moore
C M
CM
Scheurer
J
J
Tebbett
I R
IR
Logan
B K
BK
D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D003042:Cocaine / Q000031:analogs & derivatives* / Q000032:analysis*; D006801:Humans; D008049:Lipase / Q000378:metabolism
C005618:benzoylecgonine; D008049:Lipase; D003042:Cocaine