[Prevention of injurious effect of free radicals to island skin flap with mannitol and anisodamine--an experimental study].
Rat abdominal skin flaps were subjected to total venous occlusion for 8 hours. Prior to and immediately following release of the vascular occlusion, mannitol, anisodamine or placebos were administered. Mannitol and/or anisodamine significantly enhanced island flap survival. LPO or water content was significantly lower in drug groups than in placebo groups. However, XOD was not affected by the drugs. These findings indicated that oxygen free-radical played an important role in post-ischemic flap injury.
Fu
W Y
WY
Department of Oral and Maxillo-facial Surgery, Qingdao Municipal Hospital.
D000818:Animals; D005609:Free Radicals; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D008353:Mannitol / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*; D013524:Surgical Flaps; D014665:Vasodilator Agents / Q000627:therapeutic use*; D014947:Wounds and Injuries / Q000601:surgery
D005609:Free Radicals; D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine; D008353:Mannitol