[Effects of morphine on adenylate cyclase activity in lymphocytes of healthy subjects and patients with alcoholism and opiate addiction].
The morphine dose 10(-7) M had practically no effect on adenylate cyclase (AC) activity in lymphocytes of healthy controls (n = 20). The same dose of morphine had a pronounced stimulating effect on the AC activity in lymphocytes of alcoholics in withdrawal (n = 16). In the group of opiate addicts in withdrawal (n = 9) morphine had also a stimulating effect, which differed significantly from controls (33.7 +/- 13.8; P. 0.02). The range of fluctuation of morphine influence on AC activity during the first week of hospitalization was 162.9 +/- 33.0% in alcoholics and 30.4 +/- 4.6% in opiate addicts (P 0.01).
Gamaleia
N B
NB
Vekshina
N L
NL
Proskuriakova
T V
TV
Tronnikov
S I
SI
Anokhina
I P
IP
D000262:Adenylyl Cyclases / Q000097:blood*; D000437:Alcoholism / Q000097:blood / Q000201:enzymology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology*; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009293:Opioid-Related Disorders / Q000097:blood / Q000201:enzymology*; D013997:Time Factors
D009270:Naloxone; D009020:Morphine; D000262:Adenylyl Cyclases
Vliianie morfina na aktivnost' adenilattsiklazy limfotsitov zdorovykh, bol'nykh alkogolizmom i opiĭnoĭ narkomanieĭ.