In vivo-in vitro correlation of salbutamol release from a controlled release osmotic pump delivery system.
The drug release of salbutamol from a controlled release (osmotic pump) tablet was determined in vitro by four different dissolution apparatuses. From published in vivo data, percent of drug absorbed and percent of drug released in vivo were estimated. The highest correlation was obtained between percentage released in vitro versus percentage released in vivo using polynomial regression.
Civiale
C
C
Biopharmaceutics Department, Faculty of Pharmacy, Clermont-Ferrand, France.
Ritschel
W A
WA
Shiu
G K
GK
Aiache
J M
JM
Beyssac
E
E
D000284:Administration, Oral; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D007408:Intestinal Absorption
D003692:Delayed-Action Preparations; D000420:Albuterol