Androgen receptors in laryngeal carcinoma and their clinical significance.
Specific radioligand [3H] methyltestosterone incubation and dextran-coated charcoal absorption technique (DCC) were used to test cytosol androgen receptors (AR) of laryngeal carcinoma in 33 patients. In all specimens, high level AR ranged from 3 to 16.9 fmol/mg of cytosol protein (mean 10 +/- 3.9 fmol/mg), and dissociation constant was 1.7 x 10(-9) mole. Laryngeal carcinoma is considered a sex hormone-dependent tumor. High level of AR in laryngeal carcinoma may indicate a super-demand on androgen; when the content of AR increases the tumor proliferates perniciously. Antiandrogen endocrine therapy may be helpful in treating laryngeal carcinoma.
Wang
J Q
JQ
Department of Otorhinolaryngology, First Affiliated Hospital, Bethune University of Medical Sciences, Changchun.
Dong
Z
Z
Zhu
J G
JG
Bu
G X
GX
Guo
X F
XF
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000737:chemistry*; D011944:Receptors, Androgen / Q000032:analysis*
D011944:Receptors, Androgen