[Morphofunctional changes in the vascular system of the rabbit brain in rocking during anti-orthostatic position and administration of dimephosphon].
It was demonstrated by experiment that exposure of non-anesthetized rabbits to rocking in the head-down position at -30 degrees led to acidosis, hypoxemia and hypercapnia, changes in impedance components that were suggestive of water imbalance in the cerebral tissue, paralytic dilation of microcirculation vessels, subarachnoidal hemorrhages, hyaline thrombi, stasis and sludge-syndrome, small perivascular extravasates in different brain compartments, marked perivascular and pericellular edema. Pretreatment with dimephosphone prevented or attenuated significantly acidosis, water imbalance, and pathomorphological disorders in the vascular system, nervous and glial elements of the brain of the rabbits examined.
Skoromnyĭ
N A
NA
Beketov
A I
AI
Vasil'ev
K K
KK
Kolbasin
P N
PN
D000818:Animals; D001921:Brain / Q000098:blood supply*; D001929:Brain Edema / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D002536:Cerebral Arteries / Q000187:drug effects / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D009068:Movement; D009943:Organophosphorus Compounds / Q000008:administration & dosage* / Q000494:pharmacology; D011187:Posture; D011817:Rabbits
D009943:Organophosphorus Compounds; C049638:dimephosphon
Morfofunktsional'nye izmeneniia sosudistoĭ sistemy golovnogo mozga krolikov pri ukachivanii v antiortostaticheskom polozhenii i primenenii dimefosfona.