title: Influence of age on neutrophil function in foals.
abstract: Functional activities (phagocytosis and killing) of neutrophil leucocytes (NL) and immunoglobulin G concentrations were evaluated in six healthy foals from birth to 6 months of age. Peripheral blood NL were reacted with Streptococcus equisimilis in 20 per cent pooled equine serum for 30, 60 and 90 mins and functional activities of NL were determined using a fluorochrome microassay. Values for foal NL function were compared with those of healthy adult horses (n = 28). Foal neutrophil function was influenced by age. Killing capacity of NL decreased, whereas phagocytic capacity increased, until 113 days of age, after which a reversal in trends became apparent. Immunoglobulin G concentrations changed significantly over time and were lowest at 29 to 56 days of age. All foal values for NL function fell within the range of normal values established for healthy adult horses.
authors.affiliation: Department of Food Animal and Equine Medicine, North Carolina State University, College of Veterinary Medicine, Raleigh 27606.
authors.forename: M G
authors.initials: MG
authors.lastname: Wichtel
authors.forename: K L
authors.initials: KL
authors.lastname: Anderson
authors.forename: T V
authors.initials: TV
authors.lastname: Johnson
authors.forename: U
authors.initials: U
authors.lastname: Nathan
authors.forename: L
authors.initials: L
authors.lastname: Smith
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D002478:Cells, Cultured; D005260:Female; D006736:Horses / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D013291:Streptococcus / Q000276:immunology
chemical_list: D007074:Immunoglobulin G