Iridoids: a new class of leishmanicidal agents from Nyctanthes arbortristis.
Iridoid glucosides (arbortristosides A [I], B [2], C [3], and 6beta-hydroxy-loganin [4] isolated from the traditional plant Nyctanthes arbortristis show antileishmanial activity in both in vitro (against amastigotes in macrophage cultures) and in vivo (in hamsters) test systems.
Tandon
J S
JS
Division of Medicinal Chemistry and Parasitology, Central Drug Research Institute, Lucknow, India.
Srivastava
V
V
Guru
P Y
PY
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification; D006224:Cricetinae; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D007893:Leishmania donovani / Q000187:drug effects*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008297:Male; D008647:Mesocricetus; D015394:Molecular Structure; D010946:Plants, Medicinal; D011714:Pyrans / Q000302:isolation & purification / Q000494:pharmacology*; D016205:Sigmodontinae
D000981:Antiprotozoal Agents; D005960:Glucosides; D011714:Pyrans