[The effect of cimetidine and gastrozepin on liver function and the pharmacotherapy of "hepatogenous" gastroduodenal ulcers and erosions].
Toxic hepatitis developed but in one out of 127 peptic ulcer patients treated with cimetidine. In patients (n-142) treated with gastrozepine, no cases of toxic hepatitis were recorded. These anti-ulcer agents did not influence absorptive capacities of the liver or hepatic blood flow. Meanwhile microsomal exidase (antitoxic) function of hepatocytes noticeably declined as a result of cimetidine treatment in every 8th patient with peptic ulcer subjected to the continuous 5-week treatment with the drug and in every 5th patient given the treatment (maintenance included) for a longer time. In patients suffering from liver cirrhosis with secondary gastroduodenal ulcers or multiple erosions, the 5-week treatment either with almagel and platyphylline or gastrozepine provided approximately similar results and promoted ulcer and erosion healing in half the cases. Adjuvant 3-week therapy with sucralfate (venter) having cytoprotective properties led to the disappearance of gastroduodenal ulcers and erosions in 23 out of 26 patients, in whom the previous treatment was ineffective.
Geller
L I
LI
Bessonova
G A
GA
Griaznova
M V
MV
D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002927:Cimetidine / Q000008:administration & dosage / Q000009:adverse effects*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D010890:Pirenzepine / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors
D000897:Anti-Ulcer Agents; D010890:Pirenzepine; D002927:Cimetidine
Vliianie tsimetidina i gastrotsepina na sostoianie pecheni i farmakoterapiia "gepatogennykh" gastroduodenal'nykh iazv i éroziĭ.