Glomerulopressin activity in carbon tetrachloride-induced cirrhosis in male rats.
The activity of glomerulopressin, a putative renal vasoregulatory hormone that is synthesized in the liver, was assayed in male rats with carbon tetrachloride-induced cirrhosis and the results were compared to glomerulopressin activity in normal-control and pair-fed animals. Glomerulopressin activity in blood samples collected from the hepatic vein of the cirrhotic group was significantly lower than the activity in the normal-control and pair-fed groups. Glomerulopressin activity in the normal-control and the pair-fed groups were not significantly different. The data support the concept that glomerulopressin deficiency in liver disease, such as cirrhosis, may play a role in the genesis of the functional renal failure associated with liver disease.
Elias
A N
AN
Department of Medicine, University of California, Irvine.
Khamiseh
G
G
Vaziri
N D
ND
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D005965:Glucuronates / Q000378:metabolism*; D006728:Hormones / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000209:etiology; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005965:Glucuronates; D006728:Hormones; C014007:glomerulopressin