title: International Federation of Clinical Chemistry (IFCC), scientific division: IFCC recommendation on sampling transport and storage for the determination of the concentration of ionized calcium in whole blood, plasma and serum.
abstract: The substance concentration of ionized calcium (cCa2+) in blood, plasma or serum preanalytically may be affected by pH changes of the sample, calcium binding by heparin, and dilution by the anticoagulant solution. pH changes in whole blood can be minimized by anaerobic sampling to avoid loss of CO2, by measuring as soon as possible or by storing the sample in iced water to avoid lactic acid formation. cCa2+ and pH should be determined simultaneously.
authors.forename: A B
authors.initials: AB
authors.lastname: Boink
authors.forename: B M
authors.initials: BM
authors.lastname: Buckley
authors.forename: T F
authors.initials: TF
authors.lastname: Christiansen
authors.forename: A K
authors.initials: AK
authors.lastname: Covington
authors.forename: A H
authors.initials: AH
authors.lastname: Maas
authors.forename: O
authors.initials: O
authors.lastname: Müller-Plathe
authors.forename: C
authors.initials: C
authors.lastname: Sachs
authors.forename: O
authors.initials: O
authors.lastname: Siggaard-Andersen
mesh_terms: D001777:Blood Coagulation; D001793:Blood Preservation / Q000379:methods*; D001800:Blood Specimen Collection / Q000379:methods*; D002118:Calcium / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000037:antagonists & inhibitors; D002624:Chemistry, Clinical; D006493:Heparin; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007390:International Agencies; D010949:Plasma / Q000737:chemistry*; D013048:Specimen Handling
chemical_list: D002135:Calcium-Binding Proteins; D006493:Heparin; D002118:Calcium