Some metabolic relationships between biopterin and folate: implications for the "methyl trap hypothesis".
Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H4-folate can regenerate BH4 from q-BH2 and q-BH2 can provide an escape from the "methyl trap."
Kaufman
S
S
Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland.
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000378:metabolism*; D000818:Animals; D001708:Biopterins / Q000378:metabolism*; D005492:Folic Acid / Q000378:metabolism*
D001708:Biopterins; D005492:Folic Acid; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase