[The transplantation of beta-cell cultures in the treatment of insulin-dependent diabetes mellitus in children].
Over 100 transplantations were performed in 86 children and adolescents with a severe course of insulin dependent diabetes mellitus. A good effect was achieved in 81 +/- 6%, in other cases the effect was uncertain. Therapy resulted in a significantly higher rate of cases of stable compensation with a lesser number of injections and a stable dose of insulin, in stabilization and regression of some complications. Transplantation was followed by an increase in the level of C-peptide 3-4 times as compared to the basal one for a period of 6 mos. A better effect was noted in a group of patients with a high residual secretion of C-peptide. An assumption was made of simultaneous secretory activity of a graft and residual beta-cell-stimulated endogenous production of insulin.
Benikova
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EA
Turchin
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IS
D000293:Adolescent; D002096:C-Peptide / Q000097:blood; D002648:Child; D003131:Combined Modality Therapy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000209:etiology / Q000601:surgery*; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000502:physiology; D012074:Remission Induction
D002096:C-Peptide
Transplantatsiia kul'tur beta-kletok v lechenii insulinzavisimogo sakharnogo diabeta u deteĭ.