title: Insulin-carrying microspheres, in vitro studies.
abstract: Loading and release characteristics of insulin-carrying albumin and starch microspheres have been studied in vitro. The sorption characteristics of 125I-labelled insulin onto albumin microspheres were studied and were found to be completed within 5h, and the loading capacity was found to be 0.14% w/w. Insulin did not show any sorption into the matrix of the starch microspheres. The release characteristics were analyzed by high performance liquid chromatography. About 80% was released within 5-10 min from albumin microspheres and starch microspheres, respectively.
authors.affiliation: Royal Danish School of Pharmacy, Department of Pharmaceutics, Copenhagen, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Gizurarson
authors.forename: E
authors.initials: E
authors.lastname: Bechgaard
mesh_terms: D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000737:chemistry; D008863:Microspheres; D013213:Starch
chemical_list: D007328:Insulin; D013213:Starch