Enhancement of amniotic fluid cell growth for genetic amniocentesis.
The last two decades have witnessed a logarithmic growth in demand for prenatal diagnosis of human disease through amniocentesis. Consequently, culture turn-around-time has become the major concern of all those who are primary care providers for patients seeking help. We report a rapid method for obtaining cytogenetic results from amniocytes as early as 5 days. Early tapping and reducing the turn-around-time during cytogenetic analysis may provide an alternative to chorionic villi sampling.
Mathews
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Division of Genetics, Long Island College Hospital, SUNY Health Science Center, Brooklyn.
Verma
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RS
D000649:Amniocentesis / Q000379:methods*; D000653:Amniotic Fluid / Q000166:cytology*; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D007621:Karyotyping / Q000379:methods; D011247:Pregnancy; D013997:Time Factors