title: [Treatment of gonococcal urethritis].
abstract: Results of the treatment of 5 cases of males with uncomplicated gonoccocal urethritis using levofloxacin (LVFX, DR-3355), the L-type optical isomer of ofloxacin (OFLX), were compared with those treated with OFLX itself. Three hundred mg/day of LVFX or 600 mg/day of OFLX was given to each patient for 5 days. Both drugs showed excellent clinical results in all the patients. When MICs of the 2 drugs were compared against 57 isolated strains of Neisseria gonorrhoeae including 3 penicillinase-producing N. gonorrhoeae, it was found that MICs of LVFX were approximately one half of those of OFLX.
authors.affiliation: Osaka Prefectural Bandai Clinic for STD.
authors.forename: K
authors.initials: K
authors.lastname: Osato
authors.forename: C
authors.initials: C
authors.lastname: Katsukawa
authors.forename: M
authors.initials: M
authors.lastname: Makino
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D006069:Gonorrhea; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000302:isolation & purification; D015242:Ofloxacin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014526:Urethritis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D064704:Levofloxacin; D015242:Ofloxacin