Nucleotide profile in rat liver and intestine at portal vein obstruction and reflow.
Liver and intestinal nucleotides and energy charge levels were examined in rats at portal vein clamping for 1, 5 or 30 min and after reflow for 1 or 6 h following 30 min clamping. In both tissues, clamping resulted in a loss of ATP, energy charge, UTP, GTP, UDP-glucuronic acid and UDP-N-acetylhexosamine levels, which all, except ATP and total adenosine phosphates, essentially recovered at 1 h reflow. At 6 h reflow, liver UDP-glucuronic acid and liver glutathione decreased in both clamped and sham operated rats.
Jakobsson
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B
Department of Pathology, Lund University, University Hospital, Sweden.
el Hag
I A
IA
Stenram
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U
D000818:Animals; D003250:Constriction; D006160:Guanosine Triphosphate / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000098:blood supply* / Q000378:metabolism; D008102:Liver Circulation; D008297:Male; D009711:Nucleotides / Q000378:metabolism*; D011169:Portal Vein / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014535:Uridine Diphosphate Glucuronic Acid / Q000378:metabolism; D014544:Uridine Triphosphate / Q000378:metabolism
D009711:Nucleotides; D014535:Uridine Diphosphate Glucuronic Acid; D006160:Guanosine Triphosphate; D014544:Uridine Triphosphate