Volume measurement of intraocular tumours by cross-sectional ultrasonographic scans.
The volume of intraocular tumours can be calculated from tumour height and cross-sectional areas measured in maximal orthogonal B-mode ultrasonograms, on the assumption that the tumour morphology is hemi-ellipsoidal. Comparison of this method with an accurate but more complex computer-aided B-mode ultrasonic tomographic method demonstrated a highly linear relationship with a correlation coefficient of 0.93. Furthermore, the comparison of cross-sectional areas measured from B-scan images and histological cross-sections in a small series of enucleated eyes demonstrated that tumour cross-sectional area measured from ultrasound images provides an accurate representation of the true physical size of the tumour in the globe. This method can be easily implemented with readily available B-mode ultrasound equipment. Unlike previously reported volume measurement methods, customised hardware or software is not required. The method is rapid and easy to perform, and may offer a useful standard method of measuring and monitoring intraocular tumours.
Gosbell
A D
AD
Department of Ophthalmology, Monash Medical Centre, Melbourne, Australia.
Barry
W R
WR
Favilla
I
I
Burgess
F
F
D002830:Choroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D015353:Eye Enucleation; D005654:Fundus Oculi; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000473:pathology; D012044:Regression Analysis; D014463:Ultrasonography