133Xenon absorption into rubber-protected portable cadmium telluride (CdTe(Cl)) detectors invalidating the 133Xenon washout method for measurement of cutaneous and subcutaneous blood flow rates in man.
The importance of 133Xenon absorption into rubber detector caps during cutaneous and subcutaneous blood flow measurement was investigated in 46 experiments involving 38 persons. 133Xenon was administered atraumatically. Cutaneous and subcutaneous washout rates were registered by portable Cadmium Telluride detectors without rubber caps, with rubber caps, and with rubber caps with Mylar membranes interposed between the rubber and the tissue investigated. No difference in rate constants obtained by means of various detector types was detected. The accumulation of 133Xenon in the rubber caps was found to take place within the first few minutes after the detectors had been brought into position. The 133Xenon then diffused back into the tissue exhibiting a great variation regarding rate constants. The 133Xenon diffused form rubber into air and perfused tissue tracing a monoexponential course; and again the rate constants would vary considerably. No correlation was found between elimination rates obtained with detectors with and without 133Xenon polluted caps, and no way of correcting for the 133Xenon content in the rubber caps was found. Relative changes in rate constants could still be recognized, but absolute values were not obtainable.
Sørensen
J L
JL
Department of Plastic and Reconstructive Surgery, Rigshospitalet, University of Copenhagen, Denmark.
D000042:Absorption; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002104:Cadmium; D019187:Cadmium Compounds; D003238:Connective Tissue / Q000098:blood supply; D005069:Evaluation Studies as Topic; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012408:Rubber; D012867:Skin / Q000098:blood supply; D013691:Tellurium; D014980:Xenon Radioisotopes
D019187:Cadmium Compounds; D014980:Xenon Radioisotopes; D002104:Cadmium; D012408:Rubber; D013691:Tellurium; C028337:cadmium telluride