Effect of erythroid differentiation factor on megakaryocytic differentiation of L8057, a murine megakaryoblastic leukemia cell line.
To assess the potent effect of erythroid differentiation factor (EDF) on megakaryocytopoiesis, effect of EDF on megakaryocytic differentiation of L8057, a murine megakaryoblastic cell line, was examined. EDF potentiated AchE induction of L8057 in a dose dependent manner. The potency of EDF on megakaryocytic differentiation is comparable to that on erythroid differentiation reported previously. The present results suggest that EDF may play a regulatory role in megakaryocytopoiesis as well as in erythropoiesis.
Nishimura
M
M
Department of Pediatrics, Yokohama City University, School of Medicine, Japan.
Kaku
K
K
Azuno
Y
Y
Okafuji
K
K
Etoh
Y
Y
Shiozaki
M
M
Sasaki
H
H
Inoue
T
T
Kaneko
T
T
D000110:Acetylcholinesterase / Q000378:metabolism; D028341:Activins; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D007265:Inhibins / Q000494:pharmacology*; D007700:Kinetics; D007942:Leukemia, Experimental; D008533:Megakaryocytes / Q000166:cytology* / Q000187:drug effects; D051379:Mice; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D028341:Activins; D007265:Inhibins; D000110:Acetylcholinesterase; D013755:Tetradecanoylphorbol Acetate