title: [Neurotoxicity of acyclovir in peritoneal dialysis apropos of 1 case].
abstract: We report a case of reversible myoclonic encephalopathy which appeared after intravenous acyclovir treatment in a patient in CAPD for which pharmacological dosages have been made in serum, peritoneal dialysate and cerebrospinal fluid (CSF). Encephalopathy appeared after two intravenous doses of 7.33 mg/kg (doses higher than recommended), administered on admission and 16 hours later. Pharmacological dosages indicated that acyclovir peritoneal clearance was negligible, and that acyclovir persisted a long time in plasma and CSF. Neurological symptoms persisted although serum concentrations returned to normal value. The diagnostic value of pharmacological dosages in serum and CSF is discussed. In addition, neurological symptoms disappeared following two consecutive hemodialysis procedures. Hence we suggest that hemodialysis could be used for drug removal in case of acyclovir overdose in CAPD patients.
authors.affiliation: Service de Néphrologie, CHU de Rennes, France.
authors.forename: I
authors.initials: I
authors.lastname: Guilhem
authors.forename: C
authors.initials: C
authors.lastname: Charasse
authors.forename: J
authors.initials: J
authors.lastname: Gary
authors.forename: S
authors.initials: S
authors.lastname: Gie
authors.forename: J
authors.initials: J
authors.lastname: Rivalan
authors.forename: P
authors.initials: P
authors.lastname: Le Pogamp
authors.forename: C
authors.initials: C
authors.lastname: Beneton
authors.forename: F
authors.initials: F
authors.lastname: Lokiec
mesh_terms: D000212:Acyclovir / Q000009:adverse effects* / Q000097:blood / Q000134:cerebrospinal fluid; D001927:Brain Diseases / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory
chemical_list: D000212:Acyclovir
vernacular_title: Neurotoxicité de l'aciclovir chez le dialysé péritonéal à propos d'un cas.