[Prevention of in vivo formation of NMBz A and the formation of oesophageal tumour by tea in rats].
Five groups of rats (22 per group) were intubated with precursors of N-Nitrosomethylbenzylamine (NMBzA), i.e. methylbenzylamine (1 mmol/kg) and sodium nitrite (0.5 mmol/kg), and five varieties of Chinese tea. One positive control group was intubated with precursors of NM2A without tea and one negative control group with tap water and sodium nitrite. After 12 week's treatment, significantly less lesions and papillomas in esophageal mucosa, examined by naked eye or by microscope, were found in the tea-treated groups than in the non-tea-treated positive control group. The results confirmed the anti-tumour ability of Chinese tea by blocking the in vivo formation of NMBzA in rats.
Xu
Y
Y
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing.
Han
C
C
D000818:Animals; D001596:Benzylamines; D002273:Carcinogens; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives*; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012977:Sodium Nitrite; D013662:Tea
D001596:Benzylamines; D002273:Carcinogens; D010936:Plant Extracts; D013662:Tea; C029991:N-methylbenzylamine; C014707:nitrosobenzylmethylamine; D012977:Sodium Nitrite; D004128:Dimethylnitrosamine