title: Cross-correlation function in the analysis of auditory brainstem response in spinocerebellar degeneration.
abstract: Cross-correlation functions were derived from the analysis of auditory-evoked brainstem response (ABR) and compared with measurements of wave latency and computed tomography findings in the assessment of ABR findings in spinocerebellar degeneration (SCD). Gender-specific normative ABR templates were produced from 30 normal males and 30 normal females separately. The cross-correlation indices used were the correlation coefficient at time 0, the maximal correlation coefficient and the latency delay in milli-seconds. The technique was applied to 33 patients with SCD. The incidence of abnormal cross-correlation functions (81.8%) was greater than the incidence of abnormal ABR peak latencies assessed according to gender (75.8%) which, in turn, was more common than the abnormal peak latencies assessed conventionally (69.7%). Moreover, the incidence of abnormal cross-correlations and latencies in Menière's disease was much lower (less than 8%). These results suggest that the evaluation of ABR waveform characteristics with cross-correlation functions using normative ABR templates of the same gender contributes to the precise detection of abnormality in the brainstem auditory pathway.
authors.affiliation: Department of Otolaryngology, Yamagata University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Aoyagi
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: J
authors.initials: J
authors.lastname: Yokoyama
authors.forename: M
authors.initials: M
authors.lastname: Sakai
authors.forename: T
authors.initials: T
authors.lastname: Kiren
authors.forename: Y
authors.initials: Y
authors.lastname: Koike
mesh_terms: D000328:Adult; D000368:Aged; D001306:Auditory Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000503:physiopathology; D008875:Middle Aged; D011930:Reaction Time; D012984:Software; D013132:Spinocerebellar Degenerations / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed