title: [Primary Sjogren's syndrome in men: evolution to acute lymphoblastic leukemia].
abstract: A clinical case of a 55-year-old man with syndrome of primary Sjögren, seronegative, normoglobulinemic and normocomplementary with 7 years of evolution, which developed acute lymphoblastic leukemia, having suffered recurrent lympho-adenopathy and paresthetic meralgia as previous clinical signs, is presented. Clinical, serological and immunologic characteristics of this syndrome are reviewed, highlighting its rare appearance among men. While appearance of malignant lymphoproliferation disorders is well known, evolution to acute or chronic myeloid leukemia is very rare and so far, an acute lymphoblastic leukemia as the one presented in this study has never been described.
authors.affiliation: Servicio de Medicina Interna, Hospital Arnau de Vilanova, Valencia.
authors.forename: A
authors.initials: A
authors.lastname: Blanes
authors.forename: A
authors.initials: A
authors.lastname: Villar
authors.forename: V
authors.initials: V
authors.lastname: Amigó
authors.forename: E
authors.initials: E
authors.lastname: Monzó
authors.forename: M
authors.initials: M
authors.lastname: González Sal
mesh_terms: D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology / Q000473:pathology*; D011289:Preleukemia / Q000276:immunology / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000276:immunology / Q000473:pathology*
chemical_list: D006680:HLA Antigens
vernacular_title: Síndrome de Sjögren primario en varón: evolución a leucemia linfoblástica aguda.