[Disorders of oxidizing metabolism as a criterion of evaluation of the course of wound healing in experimental animals].
The authors carried out 90 experiments in fertile male Wistar rats and 10 experiments in rabbits with noncomplicated and complicated (infectious) wounds. We have revealed in the first 24 hours the characteristic changes of pro- and antioxidation potentials and acid-alkaline condition of blood plasma. The increasing of specific activity of LPO product by 30-40% and the decreasing of hydroperoxides level in comparison with the initial levels of these indicators and the decreasing of blood pH point out the possibility of purulent inflammation development in postoperative wounds. We can use the special treatment of purulent inflammatory wounds in early stages of its development by the meaning of prognostication of wound healing that is very valuable in medical practice.
Zakharov
V V
VV
Nikolaev
A V
AV
Ragimov
Ch R
ChR
Khokhlov
A P
AP
Shekhter
A B
AB
Cherkasova
M E
ME
Kirsanov
V Iu
VIu
D000818:Animals; D006861:Hydrogen Peroxide / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D015227:Lipid Peroxidation; D008297:Male; D010084:Oxidation-Reduction; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism; D013492:Suppuration; D013530:Surgical Wound Infection / Q000097:blood / Q000378:metabolism*; D013997:Time Factors; D014945:Wound Healing
D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase
Narushenie okislitel'nogo metabolizma kak kriteriĭ otsenki techeniia ranevogo protsessa v éksperimente.