title: [Drug therapy of vesico-ureteral reflux in children].
abstract: The results of medical management of primary vesicoureteric refluc in 138 children aged 3 months to 15 years are presented. All children were kept on long-term, low-dose continuous chemoprophylaxis of urinary tract infection. During the 2-6 years follow-up period serial urine cultures, interval radiographic revaluation, renal function tests and blood pressure measurements were performed. Refluc disappeared spontaneously in 91 patients (66%), persisted in 9.4% and was later on surgically corrected in 20% of children. The refluc grade at presentation was the most important factor affecting the outcome: the refluc disappeared from 72% of affected ureters with grade I and II, and from 28% of ureters with grade III and IV. The presence of renal scaring and recurrence of urinary tract infection during the chemophylaxis did not influence the percentage of cured patients. Nevertheless, the mean duration of refluc from diagnosis to its spontaneous resolution was significantly longer in children with renal scars and urinary tract infections compared with its duration in children who had neither scars, nor further infections. Renal scarring progressed in 2.8% patients. Chronic renal failure developed, in spite of spontaneous resolution of refluc, in only one child with hypertension and bilateral renal scars at presentation. It is concluded that medical treatment of vesicoureteric refluc in most of the children is successful and in regard of preserving renal function stage.
authors.affiliation: Mother and Child Health Institute of Serbia.
authors.forename: V
authors.initials: V
authors.lastname: Nikolić
authors.forename: R
authors.initials: R
authors.lastname: Bogdanović
authors.forename: A
authors.initials: A
authors.lastname: Cvorić
authors.forename: M
authors.initials: M
authors.lastname: Ognjanović
mesh_terms: D000293:Adolescent; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*; D014718:Vesico-Ureteral Reflux / Q000209:etiology / Q000628:therapy*
chemical_list: D000892:Anti-Infective Agents, Urinary
vernacular_title: Medikamentna terapija vezikoureternog refluksa kod dece.