title: Effect of sustained release and pulse release anthelmintic intraruminal devices on development of pathophysiological changes and parasite populations in calves infected with Ostertagia ostertagi and Cooperia oncophora.
abstract: An experiment was conducted in calves to investigate the effect of sustained release and pulse release anthelmintic intraruminal boli on the development of pathophysiological changes following daily infection with Ostertagia ostertagi and Cooperia oncophora for six weeks. After infection various pathophysiological changes were detected including increases in serum pepsinogen concentration, enteric plasma protein losses and in the catabolic rate of albumin. Such changes developed rapidly in the unprotected calves following patency after 17 days and persisted until the termination of the study. There were indications that the sustained anthelmintic release device was more efficacious than the pulse anthelmintic release device in reducing the worm burdens and early pathophysiological changes associated with infection. It was found at necropsy that the release of anthelmintic by the oxfendazole pulse release bolus had been delayed in several calves.
authors.affiliation: University of Glasgow Veterinary School.
authors.forename: P H
authors.initials: PH
authors.lastname: Holmes
authors.forename: K
authors.initials: K
authors.lastname: Bairden
authors.forename: D
authors.initials: D
authors.lastname: McKechnie
authors.forename: G
authors.initials: G
authors.lastname: Gettinby
authors.forename: P N
authors.initials: PN
authors.lastname: McWilliam
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use; D001798:Blood Proteins / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009015:Morantel / Q000008:administration & dosage / Q000627:therapeutic use; D010029:Ostertagiasis / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D010435:Pepsinogens / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D001798:Blood Proteins; D003692:Delayed-Action Preparations; D010435:Pepsinogens; D012709:Serum Albumin; D009015:Morantel; C011030:oxfendazole