title: Long-latency auditory event-related potentials in schizophrenia and in bipolar and unipolar affective disorder.
abstract: Long-latency auditory event-related potentials were examined in 96 subjects with schizophrenia, 99 with bipolar affective disorder and 48 with major depressive (unipolar) disorder, and compared with 32 in-patient and 213 normal controls. The latency of the P3 component was significantly greater in the schizophrenic and bipolar subjects compared to other groups. The difference was stable with respect to clinical state at the time of testing and was not due to age differences or the effect of psychotropic medications. The results support the clinical distinction between bipolar and unipolar affective disorders, but also show that P3 change is not specific to schizophrenia and found in bipolar but not unipolar affective disorder.
authors.affiliation: Department of Psychiatry, University of Edinburgh.
authors.forename: W J
authors.initials: WJ
authors.lastname: Muir
authors.forename: D M
authors.initials: DM
authors.lastname: St Clair
authors.forename: D H
authors.initials: DH
authors.lastname: Blackwood
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001288:Attention / Q000187:drug effects / Q000502:physiology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D004569:Electroencephalography / Q000187:drug effects / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009497:Neurotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D010554:Personality Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D010897:Pitch Discrimination / Q000187:drug effects / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D011619:Psychotropic Drugs / Q000627:therapeutic use; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology*; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation
chemical_list: D011619:Psychotropic Drugs