Cyclosporin-induced hypertriglyceridemia with prompt response to plasma exchange therapy.
A case of severe cyclosporin-induced hypertriglyceridemia that prompted plasma exchange therapy is reported. Hyperlipemic retinitis, headache, stupor, and peripheral paresthesias became apparent when the level of triglycerides exceeded the 1,500 mg/dL level. Two plasma exchanges were required to halt disease progression. This is the second time that plasma exchange was used in a bone marrow transplanted patient on cyclosporin-A therapy. In both cases hypertriglyceridemia became apparent and symptomatic after approximately 7 months of therapy with cyclosporin.
Valbonesi
M
M
Immunohematology Services, San Martino University Hospital, Genova, Italy.
Occhini
D
D
Frisoni
R
R
Malfanti
L
L
Capra
C
C
Gualandi
F
F
D000293:Adolescent; D001629:Bezafibrate / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced / Q000188:drug therapy / Q000628:therapy*; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D010951:Plasma Exchange; D011183:Postoperative Complications / Q000139:chemically induced / Q000188:drug therapy / Q000628:therapy*; D011241:Prednisone / Q000627:therapeutic use
D016756:Immunoglobulins, Intravenous; D016572:Cyclosporine; D011241:Prednisone; D001629:Bezafibrate