title: [Personal experience with the hypolipidemic agent Olbetam-Acipimox in hyperlipoproteinemia associated with type II diabetes].
abstract: The objective of this work was to test in type II diabetics with hyperlipoproteinaemia the action of a new analogue of nicotinic acid--Acipimox (Olbetam, Farmitalia Carlo Erba). The investigation comprised 24 patients of whom 16 took for three months Olbetam (250 mg 3 x per day by the oral route) and 8 patients were given placebo. The investigated biochemical parameters were examined before administration of the preparation was started and 4 and 12 weeks following its administration. Contrary to the group taking placebo, in the group taking Olbetam a significant decline of the triglyceride serum level occurred and a slight decline of total serum cholesterol levels and increase of HDL-cholesterol and the atherogenic risk indexes were thus more favourable. The results indicate that Olbetam is a satisfactory hypolipidemic agent for the treatment of diabetic hyperlipoproteinaemia.
authors.affiliation: Ustav experimentálnej endokrinológie SAV, Bratislava.
authors.forename: E
authors.initials: E
authors.lastname: Rajecová
authors.forename: A
authors.initials: A
authors.lastname: Kréze
authors.forename: I
authors.initials: I
authors.lastname: Klimes
authors.forename: A
authors.initials: A
authors.lastname: Cvrkalová
authors.forename: A
authors.initials: A
authors.lastname: Lacko
authors.forename: H
authors.initials: H
authors.lastname: Langrová
authors.forename: E
authors.initials: E
authors.lastname: Hanzen
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011719:Pyrazines / Q000627:therapeutic use*
chemical_list: D000960:Hypolipidemic Agents; D008055:Lipids; D011719:Pyrazines; C027696:acipimox
vernacular_title: Nase skúsenosti s hypolipemikom Olbetam-Acipimox pri hyperlipoproteinèmii u diabetu II. typu.