title: Effect of Eupatorium odoratum on blood coagulation.
abstract: The purified compound, 4', 5, 6, 7-tetramethoxyflavone, is an active ingredient isolated from Eupatorium odoratum, a Thai indigenous plant that has long been used to stop bleeding. This compound was studied in vitro for the effect on blood clotting factor activities. It was found that the compound enhanced blood coagulation, the observed APTT being shorter than that observed in the control. The result suggested that the compound accelerated clotting time through the intrinsic pathway of the coagulation which may involve the reaction of factor XII, factor XI, factor IX or factor VIII.
authors.affiliation: Department of Oral Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Triratana
authors.forename: R
authors.initials: R
authors.lastname: Suwannuraks
authors.forename: W
authors.initials: W
authors.lastname: Naengchomnong
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D005419:Flavonoids / Q000494:pharmacology; D006801:Humans; D010314:Partial Thromboplastin Time; D010946:Plants, Medicinal / Q000737:chemistry; D013785:Thailand
chemical_list: D005419:Flavonoids; C072809:4',5,6,7-tetramethoxyflavone