Insulin-tumour interrelationships in thymoma bearing mice. Effects of dietary glucose and fructose.
Control (C) or Thymoma (T) implanted male C57BL/6J mice received a basal diet containing 16.5% glucose (G) or fructose (F). Compared to the C-G group, the C-F mice consumed more food and less water, and gained more weight. The blood glucose, insulin and triglyceride levels were higher in the C-F than in the C-G mice. Thymoma implantation into the right flank caused a transient decrease in body weight followed by a steady increase due to tumour growth. Tumours were detected earlier and tumour size was greater in the T-F group than in the T-G mice. Tumour chemical composition was similar in both groups. Blood analysis showed that the T mice had lower glucose and higher insulin and triglyceride levels than the C group. Carcasses from the T groups contained more water and ash and less fat than their C counterparts, but the type of sugar did not affect the body composition of the C or T groups. The results suggest that dietary fructose may enhance the growth of tumour via its hyperinsulinaemic action.
Yam
D
D
Weizmann Institute of Science, Rehovot, Israel.
Fink
A
A
Nir
I
I
Budowski
P
P
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004327:Drinking Behavior; D005247:Feeding Behavior; D005632:Fructose / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013945:Thymoma / Q000473:pathology / Q000503:physiopathology*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin; D014280:Triglycerides; D005632:Fructose; D005947:Glucose