Phagocytic function of neutrophils during dialysis in relation to some immunological findings.
Haemodialysis neutropenia and impaired granulocyte function are transitory, but the consequences of altered granulocyte function are observed at the end of haemodialysis. Activity of polymorphonuclear receptor for Fc and C3 complement component, circulating immune complexes and components of complement (C1 inactivator, C4, C3, C3 proactivator) were measured in ten patients before and at the end of haemodialysis. Significant decrease in polymorphonuclear Fc receptor activity (1689 cells/mm3 before and 1277 cells/mm3 after HD) and increase of circulating immune complexes (69.9 micrograms/dl before and 112.7 micrograms/dl after HD) were observed at the end of haemodialysis. A decrease in complement C3 component was observed after haemodialysis (866 mg/l before and 804 mg/l after HD); the other components: C1 inactivator, C4 component, and C3 proactivator, remained unchanged. Increase of circulating immune complexes and decrease of Fc receptor activity correlated with a decrease in phagocytic function of polymorphonuclear leukocytes.
Ksiazek
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Department of Nephrology, Medical School, Lublin, Poland.
Kozioł
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D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood; D003165:Complement System Proteins / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology / Q000628:therapy; D016177:Macrophage-1 Antigen / Q000097:blood; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D011961:Receptors, Fc / Q000378:metabolism; D006435:Renal Dialysis / Q000009:adverse effects*
D000936:Antigen-Antibody Complex; D016177:Macrophage-1 Antigen; D011961:Receptors, Fc; D003165:Complement System Proteins