title: Pharmacokinetics of alpha-dihydroergocryptine in rats after intravenous and oral administration.
abstract: The pharmacokinetic properties of alpha-dihydroergocryptine methanesulphonate (alpha-DHEK, CAS 19467-62-0) were investigated in rat using a radioimmunoassay technique for nonmetabolized drug. alpha-DHEK, intravenously administered at the dose of 6 mg/kg, showed a plasma profile according to an open 3-compartment pharmacokinetic model with a long half-life (about 7.56 h). The kinetics of alpha-DHEK after oral administration (6 mg/kg) showed two peaks; the second peak at 8 h was probably due to an enterohepatic cycle. The disposition of alpha-DHEK consisted in a fast absorption and a slow elimination (t1/2el about 6.78 h). The alpha-DHEK was largely metabolized as results from the complex metabolite profile in body fluids and from very low urinary elimination of unchanged drug.
authors.affiliation: Department de Recherche en Imagerie, Pharmacologie et Physiologie, Centre d'Etudes Nucléaires de Saclay, Gif-sur-Yvette, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Grognet
authors.forename: M
authors.initials: M
authors.lastname: Istin
authors.forename: A
authors.initials: A
authors.lastname: Zanotti
authors.forename: F
authors.initials: F
authors.lastname: Mailland
authors.forename: G
authors.initials: G
authors.lastname: Coppi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004088:Dihydroergotoxine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D011863:Radioimmunoassay; D051381:Rats
chemical_list: D004088:Dihydroergotoxine