Imipenem/gentamicin and imipenem/rifampin against methicillin-resistant Staphylococcus aureus.
The combinations of imipenem with gentamicin and imipenem with rifampin were studied by the time-kill method against 20 strains of methicillin-resistant Staphylococcus aureus. Twelve strains were resistant to imipenem, 18 resistant to gentamicin, 5 resistant to both imipenem and gentamicin and 5 resistant to imipenem, gentamicin and rifampin. Imipenem/gentamicin was synergistic against 1 strain and antagonistic against another strain. Imipenem/rifampin was synergistic against 4 strains and antagonistic against 3 other strains.
Watanakunakorn
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Department of Internal Medicine, St. Elizabeth Hospital Medical Center, Youngstown, Ohio.
D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology*; D015378:Imipenem / Q000494:pharmacology*; D016106:Methicillin Resistance; D012293:Rifampin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D005839:Gentamicins; D015378:Imipenem; D012293:Rifampin