Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19).
We report here a rare case of intrathoracic undifferentiated carcinoma in an 11-year-old girl. The biopsy tissue stained with antibodies against cytokeratin and carcino-embryonic antigen. The same staining was obtained using a cell line, PER-403, which was derived from the tumor. DNA from PER-403 cells was tested for the presence of Epstein-Barr virus genes, yielding a negative result. The cytogenetic analysis found a translocation t(15;19) (p12;q13), which has not previously been described in a carcinoma.
Kees
U R
UR
Department of Haematology-Oncology, Western Australian Research Institute for Child Health, Princess Margaret Hospital, Perth.
Mulcahy
M T
MT
Willoughby
M L
ML
D002277:Carcinoma / Q000000981:diagnostic imaging / Q000235:genetics*; D002648:Child; D002884:Chromosomes, Human, Pair 15; D004273:DNA, Neoplasm / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008854:Microscopy, Electron; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics*; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic / Q000235:genetics*; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm