title: [Immunomorphological analysis of prolonged intoxication by low doses of herbicide simazine].
abstract: Dynamic investigation of several immunologic data and complex morphologic study of the thymus of rats fed for a long time (6 months) by very low doses of herbicide simazine have been carried out. Chronic simazine treatment resulted in the development of the secondary immunodeficient state with the damage of T lymphocytes. The morphologic signs of this process were the disarray in thymus structure (dystrophic changes and intercellular contact break of nurse cells, sclerosis of microvessel walls and stromal elements), severe decrease of the T lymphocyte number in peripheral blood, inhibition of phagocytosis reaction of neutrophils.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Barshteĭn
authors.forename: G K
authors.initials: GK
authors.lastname: Paliĭ
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Persidskiĭ
authors.forename: V O
authors.initials: VO
authors.lastname: Ben'iaminov
authors.forename: M S
authors.initials: MS
authors.lastname: Pushkar'
mesh_terms: D000818:Animals; D006652:Histological Techniques; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D008854:Microscopy, Electron; D012157:Mononuclear Phagocyte System / Q000276:immunology; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains; D012839:Simazine / Q000008:administration & dosage / Q000506:poisoning*; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
chemical_list: D012839:Simazine
vernacular_title: Immunomorfologicheskiĭ analiz dlitel'noĭ intoksikatsii malymi dozami gerbitsida simazina.