title: Prevalence of Helicobacter pylori in patients with end-stage renal failure and renal transplant recipients.
abstract: The prevalence of Helicobacter pylori was determined using an ELISA technique for IgG antibodies to H. pylori in 76 patients with end-stage renal failure who were receiving regular haemodialysis and 202 patients with functioning renal transplants. Twenty-seven (34%) of the haemodialysis group and 58 (29%) of the transplant group were positive for H. pylori IgG antibodies, and the prevalence did not differ significantly from that in 247 age-matched healthy controls. In the haemodialysis group, patients positive for H. pylori were older, median age 60 years (range 22-73), compared to those patients without H. pylori antibodies, median age 52 years (range 22-75), p less than 0.05, more suffered from dyspeptic symptoms, 35 vs. 10% (p less than 0.01), yet fewer had been prescribed aluminium-containing antacids, 38 vs. 78% (p less than 0.01). In the transplanted group, those positive for H. pylori were more symptomatic for dyspepsia, 30 vs. 11% (p less than 0.01), and had lower serum creatinine values, 136 +/- 10 mumol/l (mean +/- SEM) vs. 172 +/- 12 mumol/l (p less than 0.05), compared to those without H. pylori antibodies. Almost all the transplant patients with H. pylori antibodies were taking steroids (98%) compared to 84% of those without antibodies (p less than 0.05). The prevalence of antibodies to H. pylori in this study was increased in symptomatic dyspeptic subjects and reduced in those patients prescribed aluminium-containing phosphate binders.
authors.affiliation: Department of Medicine, St. James's University Hospital, Leeds, UK.
authors.forename: A
authors.initials: A
authors.lastname: Davenport
authors.forename: T M
authors.initials: TM
authors.lastname: Shallcross
authors.forename: J E
authors.initials: JE
authors.lastname: Crabtree
authors.forename: A M
authors.initials: AM
authors.lastname: Davison
authors.forename: E J
authors.initials: EJ
authors.lastname: Will
authors.forename: R V
authors.initials: RV
authors.lastname: Heatley
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D005260:Female; D016481:Helicobacter Infections / Q000209:etiology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000150:complications / Q000276:immunology / Q000382:microbiology*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G