Current issues in evaluating the efficacy of oral poliovirus vaccine and inactivated poliovirus vaccine immunization.
Although epidemic poliomyelitis in the United States has been eliminated, there are a number of current issues that concern the use of oral attenuated poliovirus vaccine in comparison with the new enhanced-potency inactivated vaccine. Although wild-type poliovirus is almost eradicated in developed nations, vaccine-induced polio exists, at a low but persistent rate. This article reviews the current issues and suggests a return to the Institute of Medicine's 1988 recommendations concerning combined immunization with inactivated poliovirus vaccine and oral poliovirus vaccine.
Plotkin
S A
SA
Pasteur Mérieux, Marnes-La-Coquette, France.
D006801:Humans; D011051:Poliomyelitis / Q000517:prevention & control*; D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral
D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral