B16 melanoma response in vivo to photochemotherapy with mitoxantrone and red light.
The cytocidal activity of light-activated mitoxantrone in mice bearing B16 melanoma was investigated. Mice inoculated with 10(6) tumor cells on day 0 were i.p. injected with 1 mg/kg body weight of mitoxantrone on days 1, 5 and 9 and exposed to 108 J/cm2 of suitably filtered red light from a halogen lamp on days 2, 6 and 10. The treatment significantly prolonged the median survival time compared to both therapy with mitoxantrone and with red light alone.
Andreoni
A
A
Centro Endocrinologia ed Oncologia Sperimentale - C.N.R., University of Naples, Italy.
Canti
G
G
Fabbrocini
G
G
Mastrocinque
M
M
Quarto
E
E
D000818:Animals; D008027:Light; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008942:Mitoxantrone / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D010778:Photochemotherapy; D013053:Spectrophotometry
D008942:Mitoxantrone