title: [The effect of the flesinoxan subtype of serotonin C1a receptor agonist on the arterial pressure in rats].
abstract: The effect of a high-affinity C1A serotonin receptor agonist flesinoxan on the arterial blood pressure and the heart rate in normotensive Wistar rats, spontaneously hypertensive rats and inherited stress-induced arterial hypertension rats was studied. It was shown that both peripheral and central administration of flesinoxan produces a decrease of blood pressure and heart rate. However, a reduction of heart rate was more pronounced at the drug peripheral administration. The sensitivity to flesinoxan in the hypertensive rats was greater than in the normotensive rats.
authors.forename: A I
authors.initials: AI
authors.lastname: Piianzin
authors.forename: N K
authors.initials: NK
authors.lastname: Popova
authors.forename: A L
authors.initials: AL
authors.lastname: Markel'
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*
chemical_list: D000959:Antihypertensive Agents; D010879:Piperazines; D011985:Receptors, Serotonin; C056895:flesinoxan
vernacular_title: Vliianie agonista serotoninovykh retseptorov C1a podtipa flezinoksana na arterial'noe davlenie u krys.