title: A prospective analysis of cholestasis in infants supported with extracorporeal membrane oxygenation.
abstract: Cholestasis develops in many infants supported with extracorporeal membrane oxygenation. We prospectively investigated the role of hemolysis and di-(2-ethylhexyl) phthalate exposure in the development of this cholestasis. Both di-(2-ethylhexyl) phthalate levels and hemolysis, as measured by maximum free hemoglobin, were significantly (p less than 0.025) associated with the degree of cholestasis. Other clinical and laboratory factors that may contribute to cholestasis were also investigated and not found to be related to the degree of cholestasis. We speculate that hemolysis during extracorporeal membrane oxygenation support produces a large bilirubin load whose excretion is inhibited by mechanisms similar to the inspissated bile syndrome and/or by di-(2-ethylhexyl) phthalate. This would result in a predominantly direct hyperbilirubinemia with little evidence of hepatocellular or canalicular injury.
authors.affiliation: Department of Medicine, Children's Hospital, Boston, Massachusetts.
authors.forename: B
authors.initials: B
authors.lastname: Shneider
authors.forename: J
authors.initials: J
authors.lastname: Cronin
authors.forename: L
authors.initials: L
authors.lastname: Van Marter
authors.forename: E
authors.initials: E
authors.lastname: Maller
authors.forename: R
authors.initials: R
authors.lastname: Truog
authors.forename: M
authors.initials: M
authors.lastname: Jacobson
authors.forename: S
authors.initials: S
authors.lastname: Kevy
mesh_terms: D000704:Analysis of Variance; D002779:Cholestasis / Q000209:etiology*; D004051:Diethylhexyl Phthalate / Q000009:adverse effects*; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology*; D007223:Infant; D011446:Prospective Studies; D012044:Regression Analysis
chemical_list: D006454:Hemoglobins; D004051:Diethylhexyl Phthalate