title: Autogenous meniscus grafts in articular cartilage defects--an experimental study.
abstract: Many methods have been attempted to repair defects in the articular cartilage involving the subchondral bone, but no satisfactory method has yet been established. We performed an experimental study utilizing autogenous meniscus grafts for defects in the articular cartilage involving the subchondral bone. Sixty-two knees of 31 rabbits were thus treated. Gross and histological examinations were performed in animals sequentially sacrificed after 2 to 24 weeks. In gross examinations, the articular surface was smooth and the degenerative changes were slight although the grafted area appeared as a piece of whitish meniscus in all experimental knees. Histologically, 12 weeks were necessary for complete union in the superficial zone of the junction between the grafted meniscus and the subchondral bone. However, the junction in the deep zone was completely united after two weeks. Degenerative changes, such as fibrillation or ulceration were not noted on the surface of the grafted meniscus. The chondrocytes of the meniscus survived for as long as 24 weeks. The autogenous meniscus graft appears to be a promising alternative for defects in the articular cartilage.
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, Tokai University, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kusayama
authors.forename: T
authors.initials: T
authors.lastname: Tomatsu
authors.forename: O
authors.initials: O
authors.lastname: Akasaka
authors.forename: N
authors.initials: N
authors.lastname: Imai
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000293:injuries* / Q000473:pathology / Q000601:surgery; D008592:Menisci, Tibial / Q000473:pathology / Q000637:transplantation*; D011817:Rabbits; D013997:Time Factors; D014182:Transplantation, Autologous