[Characterization of novel partial t-haplotypes tM1, tM2, tM3, tM4].
The results of genetic analysis of the effects of four novel partial mouse TM-haplotypes are presented in this work. Fertility and viability of tM/tM homozygotes and tM/t6 compounds, transmission ratio distortion (trd) in males heterozygous for tM, suppression of recombination and taillessness effects were studied. Three novel t-haplotypes tM1,2,4 are viable and heterozygous for these haplotypes males T/tM show low trd (20-30%). Comparison of these data and the t6-haplotype structure suggests that the tM1,2,4-haplotypes were derived as a result of recombination events in the non-inverted T-complex fragment located between two inversions. The tM3-haplotype is semilethal and heterozygous T/tM3 males show the trd equal to that of t6-heterozygotes. Homozygous tM3/tM3 and tM3/t6 male compounds are fertile or subfertile. Potential recombination ways of derivation of tM3 are discussed.
Shustrova
I V
IV
Safronova
L D
LD
Mitrofanov
V G
VG
D000818:Animals; D005298:Fertility / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D011995:Recombination, Genetic / Q000235:genetics*; D013489:Suppression, Genetic / Q000235:genetics; D013623:Tail / Q000502:physiology
Kharakteristika novykh chastichnykh gaplotipov tM1, tM2, tM3, tM4.