title: Genetic transmission of migraine without aura: a study of 68 families.
abstract: 68 randomly selected patients with migraine without aura (M) and 4 generations of their relatives (N = 394) were studied in order to probe the genetic hypothesis of migraine. Significantly more of the probands were women and M was significantly more frequent among female relatives. Earlier onset was commoner among male probands. A genetic component of M is indicated by the very high frequency of at least one affected relative (85.3%) and by a disease prevalence that is similar among both first and second degree relatives. A simple autosomal mode of transmission seems unlikely from analysis of the data on the affected relatives, while a "sex-limited" transmission mode is suggested.
authors.affiliation: Centro Cefalee, Istituto Nazionale Neurologico, C. Besta, Milano.
authors.forename: D
authors.initials: D
authors.lastname: D'Amico
authors.forename: M
authors.initials: M
authors.lastname: Leone
authors.forename: F
authors.initials: F
authors.lastname: Macciardi
authors.forename: S
authors.initials: S
authors.lastname: Valentini
authors.forename: G
authors.initials: G
authors.lastname: Bussone
mesh_terms: D000328:Adult; D000367:Age Factors; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000235:genetics*; D012737:Sex Factors