Effect of cerebral ischemia on hypotension-induced increase in plasma vasopressin and hepatic glycogen concentration in the rat.
The effect of cerebral ischemia on the vasopressin response to hemorrhagic hypotension and on the hepatic and muscular glycogen mobilization was studied in rats. The addition of cerebral ischemia to the hemorrhage required withdrawal of significantly more blood to lower mean arterial pressure (MAP) to 50 mmHg but not if combined with ganglionic blockade. The increase in plasma vasopressin concentration during hypotension was not significantly different in rats with and without concurrent cerebral ischemia. Ganglionic blockade blunted the vasopressin response. Thus cerebral ischemia in fact attenuated the vasopressin response to hemorrhage. One hour after the insult, the hormone concentration in rats exposed to combined cerebral ischemia and hemorrhagic hypotension without ganglionic blockade was still above control levels and higher than in all other groups. Concomitantly the hepatic but not the muscular glycogen concentration in these rats was significantly lower than in the other groups.
Karlsson
B R
BR
Institute for Experimental Medical Research, University of Oslo, Norway.
Grögaard
B
B
Höglund
U
U
Gerdin
B
B
Steen
P A
PA
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood*; D002545:Brain Ischemia / Q000150:complications / Q000378:metabolism*; D006470:Hemorrhage / Q000150:complications / Q000378:metabolism; D007022:Hypotension / Q000150:complications / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000150:complications / Q000378:metabolism
D008112:Liver Glycogen; D001127:Arginine Vasopressin