Early graft injuries after pancreatic transplantation in syngeneic rats. Cytoprotective effects of gabexate-mesilate.
Failures in experimental and human pancreatic transplantation are mainly attributable to rejection, graft thrombosis, and technical problems. There are, however, problems related to other causes, such as preservation injuries, which we found to exhibit, at least within the first 6 h, the same histological patterns seen in experimental acute pancreatitis. We performed pancreatic transplantation in 110 syngeneic rats under different preservation techniques and administration of gabexate mesilate, a synthetic protease inhibitor. The results showed that antiprotease treatment reduces graft preservation injuries significantly.
Bassi
C
C
Clinica Chirurgica, University of Verona, Italy.
Benetti
L
L
Girelli
R
R
Falconi
M
M
Nifosí
F
F
Coviello
G
G
Cavallini
G
G
Vesentini
S
S
Dragonetti
C
C
Pederzoli
P
P
D000704:Analysis of Variance; D000818:Animals; D004487:Edema / Q000209:etiology; D016670:Gabexate / Q000008:administration & dosage / Q000494:pharmacology*; D006085:Graft Survival; D009336:Necrosis; D009926:Organ Preservation; D010179:Pancreas / Q000473:pathology; D016035:Pancreas Transplantation; D010195:Pancreatitis / Q000209:etiology / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*
D015842:Serine Proteinase Inhibitors; D016670:Gabexate