Effects of nimodipine on psychological-stress situation in aged rats.
Female aged rats treated with nimodipine, a calcium-blocker dihydropyridine derivative, were submitted to a psychological-stress situation. Nimodipine at the doses of 3 and 6 mg/Kg antagonized the stress-related body-weight decrease and lethality. These findings seem to validate the role of Ca-mediated mechanisms in the physiopathology of stress and the protective effects of the Ca-blockers in the stress-related illnesses.
De Marino
V
V
Department of Human Communicative Sciences, II School of Medicine, University of Naples, Italy.
Pisanti
N
N
Capone
D
D
D000367:Age Factors; D000374:Aggression / Q000187:drug effects; D000818:Animals; D001007:Anxiety / Q000209:etiology; D001362:Avoidance Learning / Q000187:drug effects*; D002118:Calcium / Q000502:physiology*; D005260:Female; D009553:Nimodipine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011917:Rats, Inbred Lew / Q000523:psychology; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology; D015431:Weight Loss / Q000187:drug effects
D009553:Nimodipine; D002118:Calcium