[Screening of single doses of the main antihypertensive drugs at rest and during various exercise tests in patients with hypertension].
The single doses of three reference antihypertensive drugs: corinfar (20 mg), anapriline (80 mg), and hypothiazide (50 mg) were screened on day 5 of drug administration at rest and during paired isometric and dynamic exercises in comparison to placebo. There was a significant decrease in blood pressures: systolic (SBP), diastolic (DBP), and mean (MBP) (p less than 0.01-0.001) at rest and during isometric and dynamic exercises after single doses of corinfar and hypothiazide versus placebo. A single dose of anapriline resulted in a significant reduction in SBP and MBP at rest and during dynamic exercise (p less than 0.05-0.001), in DBP at rest (p less than 0.05) and in an insignificant decrease in SBP, DBP, and MBP during isometric exercise and DBP during dynamic exercise. The agents were graded in terms of the effect of placebo from the mean group and individual hypotensive effects (by each blood pressure parameter). The resting dynamic exercise failed to yield some new evidence for determining the efficacy of corinfar and hypothiazide, whereas it was informative for anapriline with regard to SBP. With respect to SBP, DBP, and MBP, isometric exercise was informative for hypothiazide.
Korinteli
M O
MO
Metelitsa
V I
VI
Ostrovskaia
T P
TP
Duda
S G
SG
Vygodin
V A
VA
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004341:Drug Evaluation; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage*; D010919:Placebos; D011433:Propranolol / Q000008:administration & dosage*; D012146:Rest / Q000502:physiology
D010919:Placebos; D006852:Hydrochlorothiazide; D011433:Propranolol; D009543:Nifedipine
Skrining razovykh doz osnovnykh antigipertenzivnykh preparatov v pokoe i s pomoshch'iu razlichnykh nagruzochnykh prob u bol'nykh gipertonicheskoĭ bolezn'iu.