[Demonstration of viral proteins and RNA in hypothalamus of mice infected by canine distemper virus].
There are a number of reports suggesting that neurological disorders may be due to infectious agents, such as viruses. In order to study the role of viruses on cellular plasticity in the central nervous system, we established a model of virus infection in the mouse. Inoculation of mouse with canine distemper virus (CDV) led to an acute encephalitis, late neurological disorders and an obesity syndrome. To analyse the role of viral replication on the development of this syndrome we studied the cerebral distribution of viral products during the course of infection. Viral proteins and RNA accumulated in mouse brain from the 9th day to the 6th week post-inoculation, particularly in hypothalamus, a cerebral structure implicated in obesity. Such selective viral tropism may explain some of the unexpected features of viral-induced disorders.
Bernard
A
A
U.M.R. 30, C.N.R.S./U.C.B.L.; Faculté de Médecine A. Carrel, Lyon.
Fevre-Montange
M
M
Giraudon
P
P
Hardin
H
H
Wild
T F
TF
Belin
M F
MF
D000818:Animals; D015152:Blotting, Northern; D004216:Distemper / Q000378:metabolism*; D005260:Female; D007031:Hypothalamus / Q000737:chemistry*; D051379:Mice; D012333:RNA, Messenger / Q000737:chemistry; D012367:RNA, Viral / Q000737:chemistry*; D014764:Viral Proteins / Q000737:chemistry*
D012333:RNA, Messenger; D012367:RNA, Viral; D014764:Viral Proteins
Mise en évidence de protéines et d'ARN viraux dans l'hypothalamus de souris infectées par le virus de la maladie de Carré.