Glomerular hyperfiltration in insulin-dependent diabetes mellitus: no evidence for enhanced activity of the renin-angiotensin-aldosterone system.
Glomerular hyperfiltration is a characteristic functional abnormality in insulin-dependent diabetes mellitus (IDDM) patients, but the underlying mechanisms remain controversial. Supine and ambulant plasma renin activity (PRA) and aldosterone were measured in ten IDDM patients with normal glomerular filtration rate (GFR), in ten IDDM patients with elevated GFR and in ten nondiabetic controls. Basal and stimulated PRA or aldosterone did not differ significantly between the three groups. These results suggest that in insulin-dependent diabetes the glomerular hyperfiltration is not causally related to hyperactivity of the renin-angiotensin-aldosterone system.
Carvalho-Braga
D
D
Department of Endocrinology, Oporto Medical School, Hospital de S. João, Portugal.
Almeida
R
R
Azevedo
M
M
Amaral
I
I
Medina
J
J
Hargreaves
M
M
D000328:Adult; D000419:Albuminuria; D000450:Aldosterone / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System; D016683:Supine Position
D000450:Aldosterone; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D012083:Renin