[The development of multiple myeloma in chronic diffuse liver diseases with a long course of monoclonal immunoglobulinopathy (a description of 2 cases)].
The authors describe 2 patients with chronic active hepatitis accompanied for many years by stable monoclonal immunoglobulinopathy. In addition to the formation of liver cirrhosis, these patients were diagnosed to have multiple myeloma. Analysis of the authors' and reported data (including those on transformation of liver cirrhosis associated with monoclonal immunoglobulinopathy to hepatocellular carcinoma) makes it possible to regard patients suffering from chronic diffuse liver diseases associated with monoclonal immunoglobulinopathy as a group at risk for paraproteinemic hemoblastosis and hepatocellular carcinoma. The pathogenesis of the development of paraproteinemic hemoblastoses and hepatocellular carcinoma in the indicated group of patients is under discussion.
Krel'
P E
PE
Andreeva
N E
NE
Aprosina
Z G
ZG
D000368:Aged; D004406:Dysgammaglobulinemia / Q000150:complications / Q000175:diagnosis; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis; D006521:Hepatitis, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D017098:IgA Deficiency; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000209:etiology*; D010265:Paraproteinemias / Q000150:complications* / Q000175:diagnosis
Razvitie mielomnoĭ bolezni pri khronicheskikh diffuznykh zabolevaniiakh pecheni, dlitel'no protekavshikh s monoklonal'noĭ immunoglobulinopatieĭ (opisanie dvukh nabliudeniĭ).