Cognitive and motor skills in achondroplastic infants: neurologic and respiratory correlates.
Thirteen infants with achondroplasia underwent psychometric testing as part of a comprehensive neurologic assessment. As a group, mental development was average and motor development was delayed, although a wide range of scores was obtained. Foramen magnum measurements were correlated with respiratory dysfunction, abnormal somatosensory evoked potentials, and delayed motor development. Abnormal polysomnogram outcome was associated with reduced mental capacity. In light of the reported increased frequency of respiratory dysfunction in achondroplasia, these findings warrant careful attention and further study.
Hecht
J T
JT
Department of Pediatrics, University of Texas Medical School, Houston 77225.
Thompson
N M
NM
Weir
T
T
Patchell
L
L
Horton
W A
WA
D000130:Achondroplasia / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002675:Child, Preschool; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000209:etiology; D007360:Intelligence; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011597:Psychomotor Performance; D012120:Respiration Disorders / Q000209:etiology* / Q000503:physiopathology; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000503:physiopathology