Age and the rate of induction of aryl hydrocarbon hydroxylase in isolated peripheral blood monocytes.
We have measured the rate of induction of the microsomal monooxygenase enzyme aryl hydrocarbon hydroxylase (AHH) in isolated peripheral blood monocytes from young and elderly donors. There was no effect of age on rate of induction. The mechanisms underlying impaired induction of drug metabolism in elderly people remain to be clarified.
George
G
G
Department of Geriatric Medicine, University of Wales College of Medicine, Cardiff.
Wynne
H
H
Woodhouse
K
K
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009000:Monocytes / Q000201:enzymology*; D012016:Reference Values
D001189:Aryl Hydrocarbon Hydroxylases