Cyclosporine A prevents neurological deterioration of patients with SAH--a preliminary report.
In the present study we found that the neurological outcome in patients anaesthetized for early clipping (up to 72 h after SAH) of a ruptured aneurysm and treated with cyclosporine A was significantly better than the neurological state of control patients without immuno-suppressive treatment. The results justify the presumption that auto-immune reactions are involved in the deterioration of the postoperative neurological state of patients with SAH after rupture of an intracranial aneurysm. Supplementing a standard surgical and pharmacological treatment with cyclosporine A seems to reduce the undesirable neurological consequences of the immunologically, induced vascular disturbance after SAH.
Ryba
M
M
Department of Neurophysiology, Polish Academy of Sciences, Warsaw.
Pastuszko
M
M
Iwanska
K
K
Bidzinski
J
J
Dziewiecki
C
C
D000328:Adult; D001327:Autoimmune Diseases / Q000517:prevention & control*; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D002546:Ischemic Attack, Transient / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000601:surgery*; D016896:Treatment Outcome
D016572:Cyclosporine