title: Systolic and diastolic pressure-volume relationships during cardiac surgery.
abstract: Seven patients undergoing elective coronary artery bypass surgery were studied to assess left ventricular (LV) performance by pressure-volume loops. LV pressure was measured by micromanometry and instantaneous LV volume by a conductance catheter. Continuous pressure-volume relationships were determined during preload reduction before and after cardiopulmonary bypass (CPB). End-systolic elastance (Ees), as the slope of the end-systolic pressure-volume relationship (ESPVR), and diastolic elastance (Ed) were calculated from these interventions. Changes in position of the Ees were assessed at V75, the value of LV end-systolic volume at 75 mm Hg of LV pressure. From pre-CPB to post-CPB, Ees increased in three patients with a decrease of V75 in two patients, and Ees decreased in four patients with a concomitant increase in V75. Ed increased significantly (P less than 0.01) following CPB, demonstrating a decrease of ventricular distensibility. It is concluded that continuous measurement of LV pressure-volume relationships using the conductance catheter is feasible and may be a useful tool to estimate LV performance during cardiac surgery.
authors.affiliation: Department of Anesthesiology, University Hospital of Maastricht, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Schreuder
authors.forename: J D
authors.initials: JD
authors.lastname: Biervliet
authors.forename: E T
authors.initials: ET
authors.lastname: van der Velde
authors.forename: K
authors.initials: K
authors.lastname: ten Have
authors.forename: A D
authors.initials: AD
authors.lastname: van Dijk
authors.forename: N G
authors.initials: NG
authors.lastname: Meyne
authors.forename: J
authors.initials: J
authors.lastname: Baan
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D001026:Coronary Artery Bypass; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D013318:Stroke Volume / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*