title: Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. I. Taxonomy of the producing organisms, fermentation and antimicrobial activity.
abstract: The dunaimycins are a new complex of spiroketal 24-membered macrolides discovered in the fermentation broth of two actinomycetes. Based on taxonomic studies these two cultures, which were isolated from soil, were identified as Streptomyces diastatochromogenes strains AB 1691Q-321 and AB 1711J-452. The dunaimycins possess both immunosuppressive and antimicrobial activity.
authors.affiliation: Pharmaceutical Products Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064.
authors.forename: J P
authors.initials: JP
authors.lastname: Karwowski
authors.forename: M
authors.initials: M
authors.lastname: Jackson
authors.forename: M L
authors.initials: ML
authors.lastname: Maus
authors.forename: W L
authors.initials: WL
authors.lastname: Kohl
authors.forename: P E
authors.initials: PE
authors.lastname: Humphrey
authors.forename: P M
authors.initials: PM
authors.lastname: Tillis
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D007166:Immunosuppressive Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D018942:Macrolides