title: Prostaglandin E2-induced inhibition of the in vitro immune response by SRBC-stimulated human lymphocytes.
abstract: Exogenous PGE2 strongly inhibits the response of human lymphocyte cultures to SRBC. This effect is mediated through a T cell inhibition since non-T cells are not significantly affected. Indomethacin, which inhibits in this system lymphocyte endogenous PGE2 synthesis increases the in vitro immune response. The effect of indomethacin is overcame by exogenous PGE2. These data may be relevant for explaining the immunomodulatory role of PGE2 following antigen challenge.
authors.affiliation: Institute of General Pathology, University of Messina, Medical School, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Misefari
authors.forename: A
authors.initials: A
authors.lastname: Valenti
authors.forename: A
authors.initials: A
authors.lastname: Cavallaro
authors.forename: V
authors.initials: V
authors.lastname: Sofo
authors.forename: G
authors.initials: G
authors.lastname: Santarpia
authors.forename: F M
authors.initials: FM
authors.lastname: Salmeri
authors.forename: D
authors.initials: D
authors.lastname: Venza Teti
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000941:Antigens; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D015232:Dinoprostone / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D012756:Sheep; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000941:Antigens; D015232:Dinoprostone; D007213:Indomethacin