[Status of liver mitochondria and rat tissue creatine kinase during administration of antivitamin K].
It has been shown that 16-18 days administration of antivitamin K (pelentan) leads to two-fold increase of prothrombin time in adult rats but does not influence the soluble brain, renal, heart, muscle and serum creatine kinase activity. No effect on metabolic function of isolated liver mitochondria has been found in contrast to the vitamin K deficient rats. Mitochondria were characterized by high value of respiration control; substance oxidation rates and internal mitochondrial Ca2+ content do not differ in the level from those of control animals. From the obtained results and data published in literature a conclusion can be drawn about only particular similarity (prothrombin time) between the antivitamin K administration and alimentary vitamin K deficit.
Sokol'nikov
A A
AA
Zharova
T V
TV
Tiulina
O V
OV
Kodentsova
V M
VM
Leĭkin
Iu N
IuN
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D003402:Creatine Kinase / Q000187:drug effects*; D005017:Ethyl Biscoumacetate / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects; D011517:Prothrombin Time; D051381:Rats; D011919:Rats, Inbred Strains
D005017:Ethyl Biscoumacetate; D003402:Creatine Kinase
Sostoianie mitokhondriĭ pecheni i aktivnost' kreatinkinazy tkaneĭ krysy pri vvedenii antivitamina K.