Effect of gomisin A in the prevention of acute hepatic failure induction.
Nearly all rats develop massive hepatic cell necrosis and die upon intravenous administration of heat-killed Propionibacterium acnes followed by a small amount of Gram-negative lipopolysaccharide 7 days later. However, when such an experimental liver disorder is induced in rats raised for 4 or more weeks on food containing 0.06% of gomisin A extracted and purified from Schizandra chinensis, the survival rate rises, histological changes of the liver improve remarkably, and splenocyte reactivity to phytohemagglutinin and pokeweed mitogen as well as splenocyte interleukin 1 productivity are retained. These results suggested the possibility that the development of acute hepatic failure may be prevented with the oral administration of gomisin A.
Mizoguchi
Y
Y
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Kawada
N
N
Ichikawa
Y
Y
Tsutsui
H
H
D000818:Animals; D034242:Cyclooctanes; D004032:Diet; D004149:Dioxoles; D007375:Interleukin-1 / Q000096:biosynthesis; D017705:Lignans; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D011083:Polycyclic Compounds / Q000627:therapeutic use*; D011425:Propionibacterium acnes; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D000637:Transaminases / Q000097:blood
D034242:Cyclooctanes; D004149:Dioxoles; D007375:Interleukin-1; D017705:Lignans; D011083:Polycyclic Compounds; C033585:schizandrol B; D000637:Transaminases