The structure and function of MHC molecules. Possible implications for the control of tumor growth by MHC-restricted T cells.
We briefly survey recent basic progress on the structure and function of MHC molecules. We call attention on a number of remaining unanswered questions, and focus on a few points which we think might be of importance in immune surveillance against tumors mediated by MHC restricted T cells. In particular, we discuss the possible peptidic nature of certain tumor antigens. Following these lines, we mention a recent approach for the in vivo activation of specific CTL.
Kourilsky
P
P
Unité de Biologie Moléculaire du Gène, U. 277 INSERM-U.A.C. 535 CNRS, Institut Pasteur, France.
Jaulin
C
C
Ley
V
V
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology* / Q000378:metabolism; D006680:HLA Antigens / Q000276:immunology / Q000378:metabolism; D006649:Histocompatibility Antigens / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D007157:Immunologic Surveillance; D007167:Immunotherapy; D008954:Models, Biological; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D009374:Neoplasms, Experimental / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology; D011487:Protein Conformation; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000951:Antigens, Neoplasm; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell