title: Evaluation of detomidine as a sedative in goats.
abstract: Intramuscular (i.m.) and intravenous (i.v.) administration of detomidine at doses of 10, 20 and 40 micrograms/kg body mass was evaluated for its sedative and analgesic properties in 15 goats (Capra hircus). The drug produced dose- and route-dependent sedation. The 10 micrograms/kg dose was effective only when administered i.v. There was no observable analgesia at this dose. Higher doses produced effective sedation and moderate analgesia of the body with either route of administration. Severe ataxia and sternal recumbency were seen in all the animals after the dose of 40 micrograms/kg. Other effects of detomidine in these goats included mild to moderate salivation, depressed respiratory rate, decreased rectal temperature, bradycardia and hyperglycaemia. Plasma concentrations of total protein, sodium, potassium and chloride were not affected.
authors.affiliation: Department of Veterinary Surgery and Radiology, College of Veterinary Science, Haryana Agricultural University, Hisar, India.
authors.forename: A P
authors.initials: AP
authors.lastname: Singh
authors.forename: P K
authors.initials: PK
authors.lastname: Peshin
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: D
authors.initials: D
authors.lastname: Sharifi
authors.forename: D B
authors.initials: DB
authors.lastname: Patil
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005069:Evaluation Studies as Topic; D006041:Goats / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C041255:detomidine