The penetration of cefpirome into the potential sites of pulmonary infection.
The concentrations of cefpirome, a new semi-synthetic cephalosporin, in the bronchial mucosa and serum were assessed after a single 1 g intravenous dose in 37 patients. Bronchoalveolar lavage allowed epithelial lining fluid (ELF) concentrations to be measured in eight subjects. The mean concentration for serum was 34.5 mg/L (S.E.M. 3.3), for bronchial mucosa 19.3 mg/kg (S.E.M. 1.9) and for ELF 7.2 mg/L (S.E.M. 1.1). The progressive reduction in cefpirome concentration in serum compared to that in bronchial mucosa and ELF is consistent with the permeability characteristics of beta-lactam antimicrobials and the barriers to movement of antimicrobial agents present in the lung.
Baldwin
D R
DR
Department of Thoracic Medicine, Dudley Road Hospital, Birmingham, UK.
Maxwell
S R
SR
Honeybourne
D
D
Andrews
J M
JM
Ashby
J P
JP
Wise
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism; D002511:Cephalosporins / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000378:metabolism*; D000097572:Cefpirome
D002511:Cephalosporins; D000097572:Cefpirome