Anthelmintic activity of paraherquamide in dogs.
Paraherquamide, an oxindole alkaloid metabolite of Penicillium paraherquei and Penicillium charlesii, was tested against the common gastrointestinal nematodes of dogs at a single oral dosage of 0.5, 1.0, or 2.0 mg kg-1. Efficacy was poor (less than 85%) against Ancylostoma caninum, Uncinaria stenocephala, Toxascaris leonina, Trichuris vulpis, and Strongyloides stercoralis at the low- and mid-dosage levels. At the high dosage level, good efficacy (91%) was observed only against S. stercoralis. Adverse reactions were observed in all dogs at every dosage level and included depression, ataxia, and protrusion of the nictitating membrane.
Shoop
W L
WL
Merck Institute for Therapeutic Research, Rahway, NJ 07065.
Eary
C H
CH
Michael
B F
BF
Haines
H W
HW
Seward
R L
RL
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D007212:Indolizines / Q000627:therapeutic use*; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D013141:Spiro Compounds / Q000627:therapeutic use*
D000871:Anthelmintics; D007212:Indolizines; D013141:Spiro Compounds; C063985:paraherquamide