[The antiacidotic and cardioprotective effects of fructose-1,6-diphosphate and dehydroascorbic acid].
The antiacidotic and cardioprotective effects of dehydro-L-ascorbic acid and fructose-1,6-diphosphate were compared in experiments of rats. It was found that the both compounds exhibit the antiacidotic effect on the model of metabolic acidosis in the isolated hypoxic heart, decrease the excess-lactate degree, increase ATP level in the myocardium and reduce the size of the necrosis area 4 hours after the modelling of myocardial infarction. The significance of the antiacidotic component in the mechanism of the cardioprotective action of the energy-supplying agents is concluded.
Sernov
L N
LN
Sokolova
O A
OA
Gatsura
V V
VV
D000138:Acidosis / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003683:Dehydroascorbic Acid / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005635:Fructosediphosphates / Q000627:therapeutic use*; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D010477:Perfusion / Q000379:methods; D051381:Rats
D005635:Fructosediphosphates; D005958:Glucosephosphates; D019298:Glucose-6-Phosphate; D000255:Adenosine Triphosphate; C029063:fructose-1,6-diphosphate; D003683:Dehydroascorbic Acid
Antiatsidoticheskiĭ i kardioprotektivnyĭ éffekty fruktozo-1,6-difosfata i degidroaskorbinovoĭ kisloty.