[Diethylnicotinamid (cordiamine) stabilization of the liver hydroxylating function in rabbits with CCl4 poisoning].
Three and ten days after the administration of CCl4 (subcutaneously, once, 4 ml/kg of 50% oil solution) there were found a decrease of the rate of antipyrine elimination (intravenously, 50 mg/kg) from the blood plasma, an increase of the total bilirubin content, ALT activity and stimulation of lipid peroxidation processes. Cordiamine administration (subcutaneously, twice a day, 3 and 10 days) exerts the normalizing effect.
Zavodnik
L B
LB
Bushma
M I
MI
Lukienko
P I
PI
Abakumov
G Z
GZ
Zverinskiĭ
I V
IV
Tsyrkunov
V M
VM
D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000818:Animals; D000983:Antipyrine / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D006900:Hydroxylation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009552:Nikethamide / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors
D009552:Nikethamide; D000410:Alanine Transaminase; D001663:Bilirubin; D000983:Antipyrine
Stabilizatsiia diétilnikotinamidom (kordiaminom) gidroksiliruiushcheĭ funktsii pecheni krolikov pri otravlenii CCl4.