Growth inhibitions on human cancer cell cultures with the indole sulphur-containing phytoalexins and their analogues.
Cell growth inhibitions on human cancer cell cultures were determined for the indole sulphur-containing phytoalexins cyclobrassinin, brassilexin (previously isolated from vegetables of the Cruciferae family) and their synthetic analogues 5-methoxybrassilexin and homocyclobrassinin. The most biologically active of these products is brassilexin (LD50 = 8 micrograms/ml).
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Institut de Chimie des Substances Naturelles, CNRS, Gif sur Yvette, France.
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D002455:Cell Division / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D007624:KB Cells; D010936:Plant Extracts / Q000494:pharmacology*; D012717:Sesquiterpenes; D013329:Structure-Activity Relationship; D013455:Sulfur; D013729:Terpenes; D014675:Vegetables; D000094162:Phytoalexins
D007211:Indoles; D010936:Plant Extracts; D012717:Sesquiterpenes; D013729:Terpenes; D013455:Sulfur; D000094162:Phytoalexins