Bilateral iris tumors in an immunosuppressed child.
A seven-year-old iatrogenically immunosuppressed girl developed simultaneous bilateral iris tumors associated with granulomatous iridocyclitis, splenomegaly, and an immunoblastic pleocytosis. Serologic studies suggested a current active Epstein-Barr virus infection. Tumor biopsy showed a polyclonal plasmacytoid lymphoproliferative process, establishing the diagnosis of posttransplant lymphoproliferative disorder. Low-dose local irradiation produced rapid and complete iris tumor regression with restoration of vision in both eyes. To our knowledge, this is the first report of ocular involvement in posttransplant lymphoproliferative disorder.
Brodsky
M C
MC
Department of Ophthalmology, University of Arkansas for Medical Sciences, Little Rock.
Casteel
H
H
Barber
L D
LD
Kletzl
M
M
Roloson
G J
GJ
D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy; D015811:Iris Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000532:radiotherapy; D016031:Liver Transplantation; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000209:etiology / Q000532:radiotherapy; D010954:Plasmacytoma / Q000175:diagnosis* / Q000209:etiology / Q000532:radiotherapy; D011183:Postoperative Complications
D016572:Cyclosporine