Clinical applications of human granulocyte-macrophage colony-stimulating factor.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that stimulates myeloid cell proliferation and maturation and enhances the function of terminally differentiated effector cells. Phase I and II clinical trials have demonstrated mild to moderate toxicities at doses of less than 30 micrograms/kg/day. These studies suggest a potential role for this growth factor to stimulate myelopoiesis in patients with aplastic anemia, myelodysplastic syndromes, AIDS, chemotherapy-induced myelosuppression, chronic neutropenia, and following bone marrow transplantation. The potential clinical uses of GM-CSF will depend on results of studies designed to optimize its therapeutic efficacy.
Sakamoto
K M
KM
Department of Pediatrics, UCLA School of Medicine 90024-1752.
Gasson
J C
JC
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000741:Anemia, Aplastic / Q000188:drug therapy; D001772:Blood Cell Count; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000009:adverse effects / Q000627:therapeutic use*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000188:drug therapy; D009503:Neutropenia / Q000188:drug therapy
D016178:Granulocyte-Macrophage Colony-Stimulating Factor