[Effect of an unbalanced food ration on induction and course of alloxan diabetes in rats].
Wistar rats were kept on a synthetic ration with different percentage of proteins (18, 9 and 50%) for 2 weeks. Then they were given subcutaneous injections of alloxan at a dose of 200 micrograms/kg of body mass. In some animals glycemia was established on the 7th day after the first administration of alloxan, in others--on the 3rd day after repeated administration of alloxan at a dose of 150 micrograms/kg of body mass. The animals were decapitated on the 14th and 30th day after establishing a hyperglycemic condition. Lethality percentage, a degree of glycemia, and at the end of the experiment insulinemia, body mass indices, indices for some organs were evaluated. A ration with an optimum and high content of protein was shown to decrease lethality percentage, reducing risks developing of a hyperglycemic condition, caused by alloxan. A ration with a high content of protein decreased a degree of severity of a diabetic condition, caused by alloxan.
Dreval'
A V
AV
Sadykova
R E
RE
Mazo
V K
VK
D000818:Animals; D015992:Body Mass Index; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004044:Dietary Proteins / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012720:Severity of Illness Index
D004044:Dietary Proteins
Vliianie nesbalansirovannosti pishchevogo ratsiona na indutsirovanie i techenie alloksanovogo sakharnogo diabeta u krys.