[Various mechanisms of regulation of lipid peroxidation in human erythrocytes after long-term exposure to hyperbaric oxygenation].
Intensity of lipid peroxidation and activity of antioxidant protection enzymes in erythrocytes were measured in three experiments with 10-24 days exposure of aquanauts under 4.6 and 5.1 MPa. It is established that there is no pathological intensification of lipid peroxidation when oxygen partial pressure in breathing gas mixture is optimal. This process is under reliable control by modulation of antioxidant enzymes activity. The high sensitivity of these research methods allows using them to determine exposure limitations under high pressure and optimal oxygen concentrations in breathing gas mixture.
Povazhenko
A A
AA
Ryzhova
T I
TI
Kozyreva
E V
EV
D000328:Adult; D002374:Catalase / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006931:Hyperbaric Oxygenation; D007101:Immersion; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D009326:Naval Medicine; D010100:Oxygen / Q000097:blood; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D014586:USSR
D002374:Catalase; D013482:Superoxide Dismutase; D010100:Oxygen
Nekotorye mekhanizmy reguliatsii peroksidatsii lipidov v éritrotsitakh cheloveka pri dlitel'nom prebyvanii v usloviiakh giperbarii.