Antimicrobial and antiviral activity of xylosyl-methylthio-adenosine, a naturally occurring analogue of methylthio-adenosine from Doris verrucosa.
Xylosyl-methylthio-adenosine, a naturally occurring analogue of 5'-deoxy-5'-methylthio-adenosine, has been postulated to play a protective role during egg development in the mollusc Doris verrucosa. However, in vitro tests showed that this analogue is devoid of activity against fungi, bacteria and viruses.
Pani
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A
Dipartimento di Biologia Sperimentale, Universitá di Cagliari, Italy.
Marongiu
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ME
Obino
P
P
Gavagnin
M
M
La Colla
P
P
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000998:Antiviral Agents / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003839:Deoxyadenosines / Q000494:pharmacology*; D008974:Mollusca / Q000737:chemistry*; D013872:Thionucleosides / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D003839:Deoxyadenosines; D013872:Thionucleosides; C014251:9-xylosyladenine; C056833:9-(5'-deoxy-5'-(methylthio)-xylofuranosyl)adenine; C008500:5'-methylthioadenosine; D000241:Adenosine