Malignant pineal teratomas: a report on three patients and the case for craniospinal irradiation following chemotherapy.
Malignant pineal teratomas carry a poor prognosis. We describe a long-term survivor after chemotherapy and craniospinal irradiation, and another who achieved only transient disease control with chemotherapy and cranial irradiation. Spinal cord spread occurred in first patient and long-term survivors have been reported following surgery and craniospinal irradiation alone, suggesting a role for craniospinal irradiation following chemotherapy.
Senan
S
S
Beatson Oncology Centre, Western Infirmary, Glasgow, U.K.
Rampling
R
R
Kaye
S B
SB
D000293:Adolescent; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D002648:Child; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005260:Female; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D010870:Pineal Gland / Q000528:radiation effects* / Q000601:surgery; D011379:Prognosis; D013116:Spinal Cord / Q000528:radiation effects; D013120:Spinal Cord Neoplasms / Q000532:radiotherapy; D015996:Survival Rate; D013724:Teratoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome