title: New developments in enzymatic peptide synthesis.
abstract: This review article describes new enzymatic methods developed for the efficient and irreversible synthesis of peptides based on native and modified proteases, and for the synthesis of polypeptides containing D- and/or unnatural amino acids. Potential opportunities for future developments in the field based on new enzymes, tailor-made catalytic antibodies, and on the technique of in vitro mutagenesis are also described.
authors.affiliation: Department of Chemistry, Scripps Research Institute, La Jolla, California 92037.
authors.forename: C H
authors.initials: CH
authors.lastname: Wong
authors.forename: K T
authors.initials: KT
authors.lastname: Wang
mesh_terms: D000577:Amides / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D002384:Catalysis; D010450:Endopeptidases / Q000737:chemistry; D005544:Forecasting; D007700:Kinetics; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013816:Thermodynamics
chemical_list: D000577:Amides; D000596:Amino Acids; D010455:Peptides; D010450:Endopeptidases