[Pharmacokinetic aspects of the combination of interferon-alpha-2b and folic acid with fluorouracil].
The plasma levels of fluorouracil (5-fluorouracil, 5FU; CAS 51-21-8) after intravenous administration have been monitored without, under influence of interferon-alpha-2b (IFN) and under influence of IFN combined with folic acid (FA). IFN causes a highly significant change of the pharmacokinetic parameters of 5FU (p less than 0.001) compared to 5FU administration without IFN. The bioavailability of 5FU (compared as the AUC0-60 values) is elevated to 80%. In contrary, the combination of IFN with FA leads to a non-significant change of the 5FU pharmacokinetics, although the bioavailability is increased to 18%. The higher plasma levels of 5FU under the influence of IFN might be causes by a changed renal clearance, which is indicated by the reduction of the total plasma clearance at about 53%. The combination IFN/FA did not show a similar effect. Yet, in both cases an improvement of the tumor response and of the clinical picture could be observed.
Czejka
M J
MJ
Institut für Pharmazeutische Chemie, Universität Wien.
Jäger
W
W
Schüller
J
J
Fogl
U
U
Schernthaner
G
G
D000368:Aged; D001682:Biological Availability; D005260:Female; D005472:Fluorouracil / Q000493:pharmacokinetics*; D005492:Folic Acid / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D008297:Male; D011994:Recombinant Proteins
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D005492:Folic Acid; D005472:Fluorouracil
Pharmakokinetische Aspekte der Kombination von interferon-alpha-2b und Folinsäure mit Fluorouracil.