The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8.
The murine gonadotropin-releasing hormone (Gnrh) locus has been mapped to mouse chromosome 14 using a mouse x Chinese hamster somatic cell hybrid panel. The equivalent human locus, known as luteinizing hormone-releasing hormone (LHRH), has been previously mapped to 8p21-8p11.2. Four other loci mapping to the human chromosome 8 short arm have been mapped to mouse chromosome 8; two of these (PLAT, GSR) lie proximal to LHRH, and two (LPL, DEF1) lie distal to LHRH. The localization of Gnrh, the murine homolog of LHRH, to mouse chromosome 14 therefore defines a hitherto unrecognized block of homology between man and mouse. Furthermore, it indicates that the region of homology between the human chromosome 8 short arm and mouse chromosome 8 is composed of two separate blocks.
Williamson
P
P
Genetics Division (Harwell), MRC Radiobiology Unit, Didcot, Oxon, England.
Lang
J
J
Boyd
Y
Y
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002875:Chromosomes; D002898:Chromosomes, Human, Pair 8; D003433:Crosses, Genetic; D004277:DNA, Single-Stranded; D007987:Gonadotropin-Releasing Hormone / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid
D004277:DNA, Single-Stranded; D007987:Gonadotropin-Releasing Hormone