title: [Clinical study of the efficacy of and tolerance to nimesulide in suppository formulation in pain-inflammatory pathologies of the ear, nose, and throat].
abstract: The efficacy and tolerability of a new pharmaceutical form of the non-steroid anti-inflammatory drug. Nimesulide have been studied in a double blind study compared with flurbiprofen, in 98 patients aged between 18 and 75 suffering from pain-inflammatory pathologies of ENT nature. Both drugs, administered in a dose of one suppository twice a day for 7 days, showed marked anti-inflammatory, analgesic and antipyretic activity and produced a significant, progressive improvement in the typical symptoms of the inflammatory state up to their complete remission. Nimesulide evidenced greater speed and duration of therapeutic action. Assessment on the effectiveness and tolerability as expressed separately by the physician and patient were positive in almost all cases of both treatments.
authors.affiliation: Istituto di Otorinolaringoiatria, Università di Catania.
authors.forename: M
authors.initials: M
authors.lastname: Rossi
authors.forename: P
authors.initials: P
authors.lastname: Monea
authors.forename: G
authors.initials: G
authors.lastname: Lomeo
authors.forename: G
authors.initials: G
authors.lastname: Tringali
authors.forename: I
authors.initials: I
authors.lastname: Scaricabarozzi
authors.forename: R
authors.initials: R
authors.lastname: Trezzani
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005480:Flurbiprofen / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010038:Otorhinolaryngologic Diseases / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D013449:Sulfonamides / Q000008:administration & dosage / Q000627:therapeutic use*; D013488:Suppositories
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D013488:Suppositories; D005480:Flurbiprofen; C012655:nimesulide
vernacular_title: Studio clinico sull'efficacia e la tollerabilità della nimesulide in formulazione supposte in patologie algico-infiammatorie otorinolaringoiatriche.