Bacterial meningitis--an update.
This report emphasizes new clinical information about bacterial meningitis in infants and children. Important elements of diagnosis include examination for the presence of shock and increased intracranial pressure. In such cases, initial treatment should focus on appropriate fluid therapy, administration of oxygen, reduction of intracranial pressure and use of corticosteroids. Currently, antibiotics of choice include ampicillin plus either cefotaxime or ceftriaxone in young infants, and one of these cephalosporins in older patients (beyond 3 months of age). Shorter durations of therapy (5 to 7 days for meningococcus, 7 days for haemophilus and 7-10 days for pneumococcus) are now commonly employed. In many centers, dexamethasone is started before the first dose of antibiotic and continued for 4 days to reduce neurologic and audiologic sequelae. Future trends will include studies of endotoxin neutralizers and non-steroidal anti-inflammatory drugs to reduce further tissue injury in meningitis. Prevention of meningitis is the ultimate goal. Since Haemophilus influenzae vaccination can now begin at 2 months, this approach may bring important results soon.
Marks
M I
MI
Department of Pediatrics, University of California, Irvine.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D003907:Dexamethasone / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000628:therapy; D008583:Meningitis, Haemophilus / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D003907:Dexamethasone