title: Effects of tryptophane on SHRSP offspring growth.
abstract: The effects of tryptophane on growth and hypertension of offspring obtained from mothers given L-tryptophane prior to mating: In the tryptophane group, body weights were heavier and blood pressures were higher than in the control group. Stroke lesion incidence rates were also much higher in the tryptophane group. At 20 weeks of age, brain enzyme activities were lower and serotonin content was higher in the tryptophane group in comparison with the control. These results suggest that dietary tryptophane may affect precocious maturation and as well as affect elevation in blood pressures due to brain serotonin turnover.
authors.affiliation: Department of Pathology, Kinki University School of Medicine, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Shiokawa
authors.forename: M
authors.initials: M
authors.lastname: Torii
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D001835:Body Weight / Q000502:physiology*; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000235:genetics; D004032:Diet / Q000009:adverse effects*; D004198:Disease Susceptibility; D005260:Female; D006973:Hypertension / Q000209:etiology* / Q000235:genetics; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D011918:Rats, Inbred SHR; D012701:Serotonin / Q000378:metabolism; D014364:Tryptophan / Q000009:adverse effects*
chemical_list: D012701:Serotonin; D014364:Tryptophan