Effect of anti-obesity drugs promoting energy expenditure, yohimbine and ephedrine, on gastric emptying in obese patients.
The effect of ephedrine, a non-selective adrenoreceptor agonist, and yohimbine, a selective alpha 2-adrenolytic drug, on gastric emptying of a radiolabelled solid meal was examined in groups of 8 (all women) and 15 (4 men and 11 women) obese patients, respectively. Patients were given orally, double-blind in random order, placebo or 50 mg ephedrine in the first group, and placebo or 15 mg yohimbine in the second group, 1.5 h prior to the gastric emptying measurement performed with the use of a gamma camera. Yohimbine did not significantly affect gastric emptying--the fraction of the meal retained within the stomach at the end of the examination (that is after 90 min), F90, amounted to 71.0 +/- 3.8% (placebo) and 66.8 +/- 4.1% (yohimbine); the gastric emptying index, Ix, was 0.737 +/- 0.106 min-1 x 10(-2) (placebo) and 0.885 +/- 0.128 min-1 x 10(-2) (yohimbine). A significant delay in gastric emptying was observed after administration of ephedrine: F90 increased from 70.3 +/- 5.1% after placebo to 80.9 +/- 3.0% after ephedrine, P less than 0.02, and Ix decreased from 0.747 +/- 0.142 min-1 x 10(-2) to 0.461 +/- 0.080 min-1 x 10(-2) after ephedrine, P less than 0.02. We conclude that the inhibitory influence of ephedrine on gastric emptying, and thus possibly on satiety, makes it a candidate for trial as pharmacological support of a low-energy diet treatment of obesity.
Jonderko
K
K
Department of Gastroenterology, Silesian School of Medicine, Katowice, Poland.
Kucio
C
C
D000328:Adult; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000187:drug effects; D004809:Ephedrine / Q000494:pharmacology*; D005260:Female; D015902:Gamma Cameras; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D008863:Microspheres; D009765:Obesity / Q000188:drug therapy* / Q000503:physiopathology*; D012709:Serum Albumin; D013667:Technetium; D015016:Yohimbine / Q000494:pharmacology*
D012709:Serum Albumin; D015016:Yohimbine; D013667:Technetium; D004809:Ephedrine