Insulin-like growth factor I (IGF-I) stimulates glucose and amino acid uptake in cultured glomerular mesangial cells.
Cultured mesangial cells possess a large number of receptors specific to IGF-I with a small number of insulin receptors. Physiological concentrations of IGF-I increased the uptakes of aminoisobutyric acid and 2-deoxyglucose in mesangial cells, while insulin exhibited similar effects only with unphysiologically high concentration. These findings suggest that, in cultured mesangial cells, IGF-I may regulate cellular metabolic functions such as glucose and amino acid uptakes through its own receptors rather than insulin receptors.
Togawa
M
M
Third Department of Medicine, Shiga University of Medical Science, Japan.
Kikkawa
R
R
Haneda
M
M
Koya
D
D
Horide
N
N
Kajiwara
N
N
Shigeta
Y
Y
D000621:Aminoisobutyric Acids / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002478:Cells, Cultured; D003847:Deoxyglucose / Q000378:metabolism*; D005920:Glomerular Mesangium / Q000187:drug effects / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D007700:Kinetics; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains
D000621:Aminoisobutyric Acids; D007328:Insulin; C100049:2-aminoisobutyric acid; D007334:Insulin-Like Growth Factor I; D003847:Deoxyglucose