title: Tl-201 uptake in brown tumors of hyperparathyroidism.
abstract: Tl-201 chloride bone scans were performed on nine patients with primary hyperparathyroidism just after Tl-201 and Tc-99m parathyroid subtraction scintigraphy. Bone lesions accumulate Tl-201, especially in sites of brown tumor formation. This was proven by the histopathologic examination of two patients. Eight patients had bone scans with Tc-99m MDP. The lesion-to-background ratio was quantified in seven patients for Tl-201 and in four patients for Tc-99m MDP. Tl-201 uptake of the lesions were quantified in two patients. The lesion-to-background ratio was 1.63 +/- 0.21 and 2.51 +/- 0.88 for Tl-201 and Tc-99m MDP, respectively. A Ga-67 citrate scan was performed on one patient, and the lesion-to-background ratio was 1.49 +/- 0.06. The accumulation of Tl-201 in brown tumors of bone might be due to increased blood flow and local metabolic activity. Tl-201 chloride was inferior to Tc-99m MDP in lesion detection. It is concluded that bone imaging with Tl-201 can easily be performed following parathyroid subtraction scintigraphy to delineate the sites of brown tumor formation.
authors.affiliation: Department of Nuclear Medicine, Eylul University, Izmir, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Durak
authors.forename: T
authors.initials: T
authors.lastname: Aras
authors.forename: C
authors.initials: C
authors.lastname: Sungur
authors.forename: G
authors.initials: G
authors.lastname: Erbengi
authors.forename: C F
authors.initials: CF
authors.lastname: Bekdik
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010002:Osteitis Fibrosa Cystica / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics
chemical_list: D013794:Thallium Radioisotopes; D013669:Technetium Tc 99m Medronate