title: Maintenance of blood pressure control in elderly hypertensives on ketoprofen.
abstract: In elderly patients, nonsteroidal anti-inflammatory drugs (NSAIDs) are often used concomitantly with antihypertensive agents. It is therefore important to assess the potential for interactions between NSAIDs and these agents. In a double-blind, placebo-controlled study, 40 elderly hypertensive patients treated with acebutolol or atenolol, together with frusemide, were randomized to receive either ketoprofen, 200 mg/day (50 mg q.i.d.), or matching placebo for 7 days. Arterial blood pressure and heart rate were monitored for a 24-hour period at baseline and at the end of treatment. Standard sphygmomanometric measurements of blood pressure and heart rate were conducted twice a day during the study. No clinically significant side effects or blood pressure or heart rate alterations were observed during the trial. The results indicate that ketoprofen does not interfere with blood pressure control in elderly hypertensive patients being treated with a combination of beta-blockers and diuretics.
authors.affiliation: Service de Médecine Interne, Centre hospitalier de Meaux, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Weiss
authors.forename: A
authors.initials: A
authors.lastname: Chenard
authors.forename: J M
authors.initials: JM
authors.lastname: De Kermadec
authors.forename: F
authors.initials: F
authors.lastname: Tertrain
authors.forename: M
authors.initials: M
authors.lastname: Abiteboul
mesh_terms: D000070:Acebutolol / Q000494:pharmacology / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001262:Atenolol / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005665:Furosemide / Q000494:pharmacology / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D015994:Incidence; D007660:Ketoprofen / Q000494:pharmacology / Q000592:standards / Q000627:therapeutic use*; D008297:Male
chemical_list: D001262:Atenolol; D000070:Acebutolol; D005665:Furosemide; D007660:Ketoprofen