Free radical-induced liver injury. I. Effects of dietary vitamin E deficiency on triacylglycerol level and its fatty acid profile in rat liver.
Effects of dietary vitamin E deficiency on the fatty acid compositions of total lipids and phospholipids were studied in several tissues of rats fed a vitamin E-deficient diet for 4, 6, and 9 months. No significant differences were observed between the vitamin E deficiency and controls except in the fatty acid profiles of liver total lipids. Triacylglycerol (TAG) accumulation was found in the liver of rats fed a vitamin E-deficient diet. The levels of TAG-palmitate and -oleate increased particularly in the liver from such animals. The fatty acid compositions of hepatic phospholipids were not affected by the diet. Increased TAG observed in the liver of rats fed a vitamin E-deficient diet was restored to normal when the diet was supplemented with 20 mg alpha-tocopheryl acetate/kg diet. These findings indicate that dietary vitamin E deficiency causes TAG accumulation in the liver and that the antioxidant, vitamin E, is capable of preventing free radical-induced liver injury.
Saypil
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WH
Department of Biochemistry, Teikyo University School of Medicine, Tokyo, Japan.
Shimasaki
H
H
Ueta
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N
D000818:Animals; D001835:Body Weight; D005227:Fatty Acids / Q000378:metabolism*; D005609:Free Radicals; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009929:Organ Size; D009928:Organ Specificity; D010743:Phospholipids / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism*; D014810:Vitamin E / Q000032:analysis; D014811:Vitamin E Deficiency / Q000378:metabolism* / Q000473:pathology
D005227:Fatty Acids; D005609:Free Radicals; D010743:Phospholipids; D014280:Triglycerides; D014810:Vitamin E