title: [Cardiac assist device with inserted alternate-drive skeletal muscle pump system].
abstract: Many studies on a skeletal muscle pump (SMP) for use as a cardiac assist device require preconditioning as a countermeasure to muscle fatigue. However, we conducted experiments in the hope of developing a cardiac assist device with an alternate-drive SMP system requiring no preconditioning. Adult mongrel dogs were used. We prepared a roll-type SMP from a pedicled muscle flap of the latissimus dorsi and major pectoris muscle, and an insert type SMP without separating the latissimus dorsi and major pectoris muscle. The muscles were stimulated at a frequency of 60 rpm at cycles of burst stimulation. Thirty-minute intermittent driving was performed. The hydrodynamic changes were measured at five-minute intervals for a total of three hours. The function of the pumps markedly declined after a few minutes of driving the roll-type SMPs but remained satisfactory after thirty minutes of driving the insert-type SMPs. Consequently, we concluded that dual SMPs, alternately driven through thirty minute intermittent drive and rest intervals, could be useful as cardiac assist devices without preconditioning.
authors.affiliation: Second Department of Surgery, Tokyo Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fujikawa
authors.forename: H
authors.initials: H
authors.lastname: Suesada
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Osada
authors.forename: T
authors.initials: T
authors.lastname: Hirayama
authors.forename: S
authors.initials: S
authors.lastname: Ishimaru
authors.forename: K
authors.initials: K
authors.lastname: Furukawa
mesh_terms: D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D004867:Equipment Design; D006353:Heart-Assist Devices; D009132:Muscles