Novel cytotoxic principles of Formosan Ganoderma lucidum.
Two new steryl esters, ergosta-7,22-dien-3 beta-yl linoleate [1] and 5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-yl linoleate [3], and a novel steroid, ergosta-7,22-diene- 3 beta,3 alpha,9 alpha-triol [5], have been isolated from the fruiting bodies of Formosan Ganoderma lucidum and characterized. A new lanostanoid, 3 beta-hydroxy-26-oxo-5 alpha-lanosta- 8,24-dien-11-one, and the new steroid exhibited potent inhibition of KB cells and human PLC/PRF/5 cells in vitro.
Lin
C N
CN
Natural Products Research Center, Kaohsiung Medical College, Taiwan, Republic of China.
Tome
W P
WP
Won
S J
SJ
D000107:Acetylation; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D008041:Linoleic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010944:Plants; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D008041:Linoleic Acids; C073073:5,8-epidioxyergosta-6,22-dien-3-yl linoleate; C073070:ergosta-7,22-diene-2,3,9-triol; C073071:ergosta-7,22-dien-3-yl linoleate; C073068:5,8-epidioxyergosta-6,9(11),22-trien-3-ol; D004875:Ergosterol