title: Resolution of early lesions of juvenile periodontitis with tetracycline therapy alone: long-term observations of 4 cases.
abstract: Our previous studies have demonstrated that early-identified lesions of localized juvenile periodontitis (LJP) can be treated by the use of systemically administered tetracycline alone (1 gm/day for 6 weeks). This therapy results in arrest of disease progression, decreased pocket depths, gains in clinical attachment, and significant repair of alveolar defects. This paper reports on the long-term clinical and radiographic improvement in 4 subjects followed for 1 to 4 years after the completion of tetracycline therapy. Four patients (mean age 14 years) were examined 1 to 4 years following the completion of a single 6 week course of tetracycline. Mean pocket depth was reduced from the initial level of 7.1 mm to 3.6 mm. Mean attachment loss was reduced from 3.8 mm to 0.9 mm and angular bone defects had filled by an average of 72%. Pocket depths and attachment loss continued to decrease during the entire study period, while alveolar bone repair continued to increase. The findings support those of our previous investigation and confirm that: 1) early identified lesions of LJP can be effectively treated with 6 weeks of tetracycline therapy alone; 2) decreases in pocket depth, gains in clinical attachment, and repair of alveolar defects remain stable up to 4 years following antibiotic therapy; 3) clinical and radiographic improvement continues over time and may lead to complete resolution of some lesions; and 4) the reparative/regenerative potential of the periodontium in early onset disease in young individuals may exceed that observed in chronic adult periodontitis.
authors.affiliation: Department of Dental Research, University of Rochester, NY.
authors.forename: M J
authors.initials: MJ
authors.lastname: Novak
authors.forename: C
authors.initials: C
authors.lastname: Stamatelakys
authors.forename: S M
authors.initials: SM
authors.lastname: Adair
mesh_terms: D000293:Adolescent; D010520:Aggressive Periodontitis / Q000188:drug therapy* / Q000473:pathology; D016301:Alveolar Bone Loss / Q000188:drug therapy / Q000473:pathology; D000539:Alveolar Process / Q000473:pathology; D003777:Dental Prophylaxis; D004846:Epithelial Attachment / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010514:Periodontal Pocket / Q000188:drug therapy / Q000473:pathology; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014945:Wound Healing
chemical_list: D013752:Tetracycline