Menotropins as a possible risk factor for premature deliveries in triplet pregnancies.
This study was undertaken in order to evaluate pregnancy outcome in three groups of triplet conceptions. Of 36 delivered triplet gestations, seven were spontaneous, 12 achieved using clomiphene citrate and 17 induced by menotropins. The mean gestational age (weeks) at delivery was 36.5 +/- 1.0 SD, for spontaneous and clomiphene citrate pregnancies it was 35.9 +/- 1.9 SD which differed significantly from that in pregnancies induced by menotropins which was 32.9 +/- 3.7 SD. Similarly, triplets born following menotropin treatment had a significantly lower gestational weight (g) of 1656 +/- 516 SD vs. 2015 +/- 198 SD and 2176 +/- 315 SD for spontaneous and clomiphene citrate gestations, respectively. It is concluded that triplets following menotropins are at an increased risk for premature delivery and low birth weight.
Mordel
N
N
Department of Obstetrics and Gynecology, Hadassah Medical Center, Jerusalem, Israel.
Laufer
N
N
Zajicek
G
G
Dorembus
D
D
Benshushan
A
A
Schenker
J G
JG
Sadovsky
E
E
D000328:Adult; D002996:Clomiphene / Q000009:adverse effects; D005260:Female; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008596:Menotropins / Q000009:adverse effects*; D007752:Obstetric Labor, Premature / Q000139:chemically induced*; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D014310:Triplets
D002996:Clomiphene; D008596:Menotropins