Alteration of DNA synthesis in human brain tumor cells by gallium nitrate in vitro.
We measured 3H-thymidine incorporation by human brain tumor cell lines treated with varying doses of gallium nitrate. These DNA synthesis data indicate that the effects of gallium documented for brain tumor cell viability parallel those for alterations in DNA synthesis. The primitive, poorly-differentiated, small, round-cell tumors (medulloblastoma and rhabdomyosarcoma) appear to be more sensitive than glially differentiated neoplasms (glioblastoma) to DNA synthesis inhibition by gallium nitrate.
Whelan
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HT
Department of Neurology, Medical College of Wisconsin, Milwaukee 53226.
Przybylski
C
C
Chitambar
C R
CR
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D005708:Gallium / Q000494:pharmacology*; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008527:Medulloblastoma / Q000378:metabolism* / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000378:metabolism* / Q000473:pathology; D013936:Thymidine; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D005708:Gallium; D013936:Thymidine; C027235:gallium nitrate