Cyclodextrin sulfates: characterization as polydisperse and amorphous mixtures.
Alpha- and beta-cyclodextrins and their hydroxypropyl derivatives were converted by the reaction with chlorosulfonic acid in pyridine to the corresponding sulfates. Cyclodextrin sulfates were shown by fast-atom bombardment mass spectrometry (negative ion mode, triethanolamine matrix) to be mixtures with nearly symmetrical distributions of degree of substitution by sulfate groups and by powder X-ray diffraction to be amorphous. Thus, in these aspects, cyclodextrin sulfates are similar to the potent drug solubilizers hydroxypropylcyclodextrins.
Pitha
J
J
NIA/GRC, National Institutes of Health, Baltimore, Maryland 21224.
Mallis
L M
LM
Lamb
D J
DJ
Irie
T
T
Uekama
K
K
D003505:Cyclodextrins / Q000737:chemistry*; D013058:Mass Spectrometry; D012995:Solubility
D003505:Cyclodextrins