Changes in a photoreceptor polypeptide correlating with an early-onset retinal dystrophy in the cat.
A preparation of rod outer segments has been used to study the polypeptides characteristic of an early-onset retinal dystrophy in cats (Rdy) by two-dimensional gel electrophoresis. Comparison of 2-D gels of rod outer segment preparations from retinas of normal and Rdy animals shows several differences. In particular, a polypeptide of Mr 51 kDa and pI 7.5 is present at increased levels in preparations from Rdy cats at 6 weeks, 9 weeks and 12.5 weeks of age but not at 3.5 weeks.
Holmes
N G
NG
Department of Immunogenetics, Animal Health Trust, Newmarket, Suffolk, UK.
Curtis
R
R
D000818:Animals; D002415:Cats; D015180:Electrophoresis, Gel, Two-Dimensional; D007525:Isoelectric Focusing; D007526:Isoelectric Point; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis*; D012162:Retinal Degeneration / Q000378:metabolism*; D012374:Rod Cell Outer Segment / Q000737:chemistry*
D010455:Peptides