[Placebo controlled study of the effect of intravenous PGE1 on macro- and microcirculation in patients with stage III/IV arterial occlusive disease].
In a randomized double-blind study i.v. PGE1 (60 mcg) leads to a significant increase of femoral blood flow, of tcPO2 and skin temperature. This effect lasts for more than one hour after infusion. Besides a slight decrease of blood pressure no severe side effects could be confirmed.
Scheffler
P
P
Angiologische Ambulanz, Universitätskliniken des Saarlandes.
de la Hamette
D
D
Leipnitz
G
G
D000527:Alprostadil / Q000008:administration & dosage*; D001157:Arterial Occlusive Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D007511:Ischemia / Q000188:drug therapy / Q000503:physiopathology; D007866:Leg / Q000098:blood supply; D008297:Male; D008833:Microcirculation / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged
D000527:Alprostadil
Placebokontrollierte Studie über die Wirkung von i.v. PGE1 auf Makro- und Mikrozirkulationen bei Patienten mit AVK Stadium III/IV.