Influence of major histocompatibility complex class I, class II and TLA genes on tumor rejection.
T lymphocytes recognize antigen associated with MHC class I and/or class II gene products. Recognition of malignant cells is therefore dependent on presentation of tumor associated antigen(s) by MHC molecules. We have studied immunity to tumors that have down-regulated class I expression. These studies demonstrate a requirement for class I antigens, but suggest that additional factors may also be required for tumor-specific immunity. The MHC also encodes TLA class I antigens, whose function is unknown. Our studies suggest that these molecules function is unknown. Our studies suggest that T lymphocytes, specifically in tumor cells that do not express H-2K or H-2D moieties. Other studies are aimed at improving tumor-specific Th cell generation by producing class II+ tumor cells. The success of these experiments indicates that this approach may be a potentially useful immunotherapy.
Ostrand-Rosenberg
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Department of Biological Sciences, University of Maryland Baltimore County 21228.
Garcia
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Roby
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Clements
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D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D006801:Humans; D007157:Immunologic Surveillance; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D012509:Sarcoma / Q000235:genetics / Q000276:immunology; D013724:Teratoma / Q000235:genetics / Q000276:immunology; D014162:Transfection
D000951:Antigens, Neoplasm; D006183:H-2 Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D010446:Peptide Fragments; C032907:Q surface antigens; D011948:Receptors, Antigen, T-Cell; C040588:Tla antigens