Hb Cleveland or alpha 2 beta 2(93)(F9)Cys----Arg;121(GH4)Glu----Gln.
Hb Cleveland is characterized by two amino acid substitutions, namely beta 121(GH4)Glu----Gln as in Hb D-Los Angeles and beta 93(F9)Cys----Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th beta chain variant with two substitutions that has been described thus far.
Wilson
J B
JB
Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912-2100.
Ramachandran
M
M
Webber
B B
BB
Kutlar
F
F
Hazelwood
L F
LF
Barnett
D
D
Hirschler
N V
NV
Huisman
T H
TH
D000328:Adult; D000595:Amino Acid Sequence; D001797:Blood Protein Electrophoresis; D005260:Female; D005914:Globins / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D006801:Humans; D007525:Isoelectric Focusing; D008969:Molecular Sequence Data; D010100:Oxygen / Q000378:metabolism; D010108:Oxyhemoglobins / Q000378:metabolism
D006455:Hemoglobins, Abnormal; D010108:Oxyhemoglobins; C072969:hemoglobin Cleveland; D005914:Globins; C026237:hemoglobin D Punjab; D010100:Oxygen