(HX)n repeats: a pH-controlled protein-protein interaction motif of eukaryotic transcription factors?
A characteristic sequence repeat of type His-X, repeated several times in a row, is present in several eukaryotic transcription factors, e.g. HPHAHPHP in paired protein. Detailed molecular modelling and database searches lead to the suggestion that (HX)n repeats can mediate interaction between transcription factors in a pH-controlled fashion.
Janknecht
R
R
Institut für Molekularbiologie, Medizinische Hochschule Hannover, Germany.
Sander
C
C
Pongs
O
O
D000595:Amino Acid Sequence; D000818:Animals; D004330:Drosophila / Q000235:genetics; D006639:Histidine; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D011487:Protein Conformation; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D014157:Transcription Factors; D006639:Histidine