Binding of potassium [3H]embelate to rat brain synaptosomes.
[3H]Embelate (potassium salt of 2,5-dihydroxy-3-undecyl-1,4- benzoquinone), a new analgesic compound, showed a specific and saturable binding in rat brain synaptosomes which was not influenced by naloxone and morphine. The binding characteristics were correlated with its non-narcotic central analgesic action.
Johri
R K
RK
Regional Research Laboratory, Jammu Tawi, India.
Zutshi
U
U
D000700:Analgesics; D000818:Animals; D016227:Benzoquinones / Q000378:metabolism*; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D010946:Plants, Medicinal; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism*
D000700:Analgesics; D016227:Benzoquinones; C010945:embelin