title: [Premalignant lesions of the laryngeal epithelium].
abstract: At the Academic Hospital of the Free University of Brussels 243 patients underwent microlaryngoscopy over a period of 11 years (1978-1989). Histologic examination disclosed premalignant lesions in 55 patients. 26 patients had a follow-up (mean follow-up time was 5 years) and were selected for this study. The patients with premalignant lesions were divided into 3 groups: group 1 = hyperplasia and/or keratosis with or without mild dysplasia (11 patients); group 2 = mild dysplasia (7 patients); group 3 = severe dysplasia and carcinoma in situ (8 patients). In group 1 no malignant transformation was seen. In group 2 one invasive carcinoma developed after a period of 5 years (14%) and in group 3 two malignant transformations appeared 14 and 15 months after the initial diagnosis (25%). The treatment of choice was a total excision biopsy or stripping. A life time follow-up with an interval period of 6 months is recommended. The patients were also motivated to change their smoking habits.
authors.affiliation: Dienst KNO, AZ, VUB, Brussel.
authors.forename: P
authors.initials: P
authors.lastname: Iwens
authors.forename: A
authors.initials: A
authors.lastname: Goossens
authors.forename: A R
authors.initials: AR
authors.lastname: Halama
mesh_terms: D000328:Adult; D000368:Aged; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000601:surgery; D007828:Laryngoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000145:classification / Q000175:diagnosis* / Q000601:surgery
vernacular_title: Premaligne lesies van het larynxepitheel.