Changes of thymocyte subpopulations induced by activities diffusing from leukemia L1210 cells.
Mice with intraperitoneally inoculated leukemia L1210 cells had a lower total number of thymocytes and a markedly reduced percentage of L3T4+ Lyt2+ (CD4+ 8+) thymocytes, but increased subpopulations of L3T4+ Lyt2-, L3T4- Lyt2+, L3T4-Lyt2-. The percentage of Thy 1.2+ thymocytes was unchanged as compared with control animals. A similar effect was observed is suggested that leukemia L1210 cells produce some activities which diffuse through 0.22 microns filters and influence the subpopulations of thymocytes.
Kawiak
J
J
Department of Cytophysiology, Medical Centre of Postgraduate Education, Warsaw, Poland.
Kawalec
M
M
Hoser
G
G
Miks
B
B
Skórski
T
T
Pojda
Z
Z
Skurzak
H
H
D000818:Animals; D015704:CD4 Antigens; D016827:CD8 Antigens; D002454:Cell Differentiation / Q000276:immunology*; D002461:Cell Line, Transformed / Q000276:immunology; D015194:Diffusion Chambers, Culture; D007939:Leukemia L1210 / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000276:immunology*; D051379:Mice; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*
D015704:CD4 Antigens; D016827:CD8 Antigens