Effects of a 13-week chloropentafluorobenzene inhalation exposure of Fischer 344 rats and B6C3F1 mice.
Chloropentafluorobenzene (CPFB) has been identified as a candidate simulant for nonpersistent chemical warfare agents. Acute toxicity studies have shown that CPFB has limited adverse effects on laboratory animals. A 21-day inhalation study of rats and mice to 2.5, 0.8, and 0.25 mg CPFB/liter resulted in reduced weight gain in male and female rats exposed at the high concentration only and identified the liver as a potential target organ. This multiconcentration inhalation study was designed to detect a no-observable-effect level associated with repeated exposure to CPFB. Male and female rats and mice were exposed to 250, 50, or 10 mg CPFB/m3 (0.25, 0.05, or 0.01 mg CPFB/liter) for 13 weeks. No treatment-related effects on body weight, clinical chemistries, mortality, absolute or relative organ weight or histopathology were noted.
Kinkead
E R
ER
Mantech Environmental Technology, Inc., Dayton, OH 45431-0009.
Bunger
S K
SK
Kimmel
E C
EC
Flemming
C D
CD
Wall
H G
HG
Grabau
J H
JH
D000280:Administration, Inhalation; D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity*; D005260:Female; D005464:Fluorobenzenes / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D005466:Fluorocarbons
D002619:Chemical Warfare Agents; D005464:Fluorobenzenes; C069395:chloropentafluorobenzene; D005466:Fluorocarbons