title: [The use of cisplatin as radiosensitizing agent in advanced tumors of the head and neck. Randomized study].
abstract: This study was aimed at assessing whether c-DDP administration immediately before radiotherapy could increase frequency and duration of objective responses, as well as survival, in patients affected with locally advanced stages of squamous carcinomas of the head and neck. All patients had already undergone two induction cycles according to the CABO schedule. Ninety-six of 108 treated patients could be evaluated. Treatment schedule consisted in: 1) randomized distribution of patients into two groups before induction chemotherapy; 2) two cycles of induction chemotherapy according to the CABO schedule in all patients; 3) radiation therapy: the patients in group A were given 5 mg/mq of i.v. cisplatin, 30-60 minutes before each session. The results from the two groups were compared and no significant differences were observed regarding objective response (82.5% in group A vs. 86% in group B), response duration and overall survival rates. Even though toxicity was higher in the patients in group A, therapeutic protocol never needed be modified.
authors.affiliation: Divisione di Radioterapia, Ospedale S. Giovanni Vecchio, Torino.
authors.forename: A
authors.initials: A
authors.lastname: Boidi Trotti
authors.forename: P
authors.initials: P
authors.lastname: Rovea
authors.forename: A M
authors.initials: AM
authors.lastname: Gabriele
authors.forename: V
authors.initials: V
authors.lastname: Tseroni
authors.forename: F
authors.initials: F
authors.lastname: Fracchia
authors.forename: M
authors.initials: M
authors.lastname: Raiteri
authors.forename: A
authors.initials: A
authors.lastname: Tardy
authors.forename: A
authors.initials: A
authors.lastname: Valle
authors.forename: O
authors.initials: O
authors.lastname: Bertetto
authors.forename: U
authors.initials: U
authors.lastname: Nastasi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011878:Radiotherapy / Q000379:methods
chemical_list: D002945:Cisplatin
vernacular_title: Utilizzazione del cisplatino come radiosensibilizzante nei tumori avanzati della regione testa-collo. Studio randomizzato.