Cytokine modulation of bacterial cell wall-induced arthritis.
Bacterial cell wall-induced arthritis in experimental animals is dependent on mononuclear cell infiltration and accumulation. These mononuclear cells secrete cytokines which promote synovial hyperplasia and erosive destruction of bone and cartilage. Whereas local administration of cytokines may exacerbate these events, systemic administration of TGF-beta or gamma IFN effectively suppresses both the acute and chronic phases of the disease.
Wahl
S M
SM
Cellular Immunology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
Allen
J B
JB
Brandes
M E
ME
D000818:Animals; D000941:Antigens / Q000276:immunology; D001168:Arthritis / Q000517:prevention & control*; D002473:Cell Wall / Q000276:immunology; D005260:Female; D007371:Interferon-gamma / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D011994:Recombinant Proteins; D013297:Streptococcus pyogenes / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
D000941:Antigens; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D007371:Interferon-gamma