Malignant transformation by mutant Rel proteins.
A newly described family of transcriptional regulatory proteins, the Rel family, has recently been the subject of much interest. The Rel family includes proteins known to be important in Drosophila development, replication of HIV-1, oncogenesis and general transcriptional control. Nevertheless, there is still much to be learned about their precise mechanism of action, including the process by which the original member of this family, v-Rel, malignantly transforms cells.
Gilmore
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TD
Department of Biology, Boston University, MA 02215.
D000595:Amino Acid Sequence; D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D020572:Oncogene Proteins v-rel; D009857:Oncogenes; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D020572:Oncogene Proteins v-rel; D015682:Retroviridae Proteins, Oncogenic; D014157:Transcription Factors