title: [Obsessive-compulsive disorder and the study of thyroid function].
abstract: We evaluated thyroid function (T3, T4, TSH) and TRH Test in 17 patients with obsessive-compulsive disorder (DSM III criteria and at least 1 year duration) not associated to major depression (absence of DSM III criteria and depression Hamilton scale score, 17 items, below 16). Blood tests were performed following a drug-free period of at least 2 weeks. We accidentally discovered one case of hyperthyroidism with the diagnosis of Graves' disease. In the remaining group (n = 16), basal values of thyroid hormones and TSH were normal. 12.5% (2 cases) showed a blunted delta TSH (less than 5 mUl/l) and 0% a high delta TSH (greater than 20 mUl/l). A significant degree of negative correlation was only noted between delta TSH and age (r = -0.65). Lastly, we report a curious comorbidity between OCD and Graves' disease found in 3 cases within a population of 50 OC patients (or 6%) recruited in our psychiatric unit. The characteristics of these observations will be presented.
authors.affiliation: Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, CHS Sainte-Anne, Paris.
authors.forename: E
authors.initials: E
authors.lastname: Hantouche
authors.forename: M L
authors.initials: ML
authors.lastname: Piketty
authors.forename: M F
authors.initials: MF
authors.lastname: Poirier
authors.forename: T
authors.initials: T
authors.lastname: Brochier
authors.forename: J P
authors.initials: JP
authors.lastname: Olié
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000503:physiopathology*; D013959:Thyroid Diseases / Q000453:epidemiology; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000502:physiology* / Q000503:physiopathology
vernacular_title: Trouble obsessionnel-compulsif et exploration de la fonction thyroïdienne.