[An electrophysiological study of the anti-arrhythmia effect of antioxidant ionol].
The paper describes the study of anti-arrhythmia effects of ionol. In isolated rabbit papillary muscle, ionol (a) had no effect on the depolarization-induced automaticity; (b) did not influence early afterdepolarizations: (c) delayed the onset of post-depolarizations initiated by Ca-overload and therefore inhibited the ectopic focal activity in myocardium. In isolated left auricles of rabbit, ionol suppressed the shortening of the excitation wavelength induced with adrenaline and thus protected the heart of reentry and consequent rhythm disturbances.
Gaĭnullin
R Z
RZ
Medvinskiĭ
A B
AB
Kozhokaru
A F
AF
Kukushkin
N I
NI
D000818:Animals; D000889:Anti-Arrhythmia Agents; D016275:Atrial Function; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D004594:Electrophysiology; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D010210:Papillary Muscles / Q000187:drug effects / Q000502:physiology; D011817:Rabbits
D000889:Anti-Arrhythmia Agents; D002084:Butylated Hydroxytoluene
Elektrofiziologicheskoe issledovanie antiaritmicheskogo deĭstviia antioksidanta ionola.