[The effect of membrane-active compounds on the radiation-modifying effect of glucose in x-irradiated ascitic tumor cells].
A study was made of the influence of membrane-active agents with different mechanisms of action (quercetin, amiloride, valinomycin, and digitonin), that modify the transmembrane transfer of inorganic ions, on a modifying effect of a glucose loading in X-irradiated Ehrlich ascites tumor cells. The combination of digitonin with glucose increased the damaging effect of radiation on tumor cells by 1.8-2.2 times as compared to glucose alone. Merely insignificant changes in the radiation-modifying effect of glucose were observed when it was combined with other membrane-active agents.
Obrokov
A F
AF
Letov
V N
VN
Veksler
A M
AM
D000584:Amiloride / Q000008:administration & dosage*; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D004072:Digitonin / Q000008:administration & dosage*; D004338:Drug Combinations; D005947:Glucose / Q000008:administration & dosage*; D066298:In Vitro Techniques; D051379:Mice; D008808:Mice, Inbred CBA; D011794:Quercetin / Q000008:administration & dosage*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000528:radiation effects*; D014634:Valinomycin / Q000008:administration & dosage*
D004338:Drug Combinations; D014634:Valinomycin; D000584:Amiloride; D011794:Quercetin; D005947:Glucose; D004072:Digitonin
Vliianie membranoaktivnykh soedineniĭ na radiomodifitsiruiushchiĭ éffekt gliukozy pri rentgenovskom obluchenii kletok astsitnoĭ opukholi.