title: Increased iron absorption in uroporphyrin-treated rats.
abstract: Rats were given 59Fe (28 micrograms) together with doses of 0, 2 and 200 micrograms of uroporphyrin III in paired observations. Absorption of 59Fe was determined by comparing whole body counts of the rats 30 min and 7 days after dosing. Prior treatment with 200 micrograms of uroporphyrin twice daily for 3 days was associated with significantly increased 59Fe absorption of 6.2% compared to the absorption of 4.6% without uroporphyrin (control) and 4.6% with a 2-micrograms dose (p less than 0.05).
authors.affiliation: Department of Medicine, Mary Imogene Bassett Hospital, Cooperstown, N.Y.
authors.forename: G A
authors.initials: GA
authors.lastname: Weaver
authors.forename: C A
authors.initials: CA
authors.lastname: Franck
authors.forename: M D
authors.initials: MD
authors.lastname: Harris
authors.forename: T
authors.initials: T
authors.lastname: Peters
mesh_terms: D000818:Animals; D007408:Intestinal Absorption / Q000187:drug effects*; D007501:Iron / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014578:Uroporphyrins / Q000494:pharmacology*
chemical_list: D014578:Uroporphyrins; C022181:uroporphyrin III; D007501:Iron