title: Pharmacokinetics of quinine and doxycycline in patients with acute falciparum malaria: a study in Africa.
abstract: The pharmacokinetics of quinine was investigated in patients with acute falciparum malaria treated with quinine alone or in the presence of doxycycline. Twenty-six patients divided into two groups of equal number were enrolled in the study. In the absence of doxycycline, the volume of distribution of quinine (mean +/- SD) was estimated to be 1.32 +/- 0.32 L/kg, and its clearance was 0.125 +/- 0.47 L/h/kg, which was only in partial agreement with previously published data. No effect of doxycycline on the pharmacokinetics of quinine was observed.
authors.affiliation: CEMAF s.a., Poitiers, France.
authors.forename: W
authors.initials: W
authors.lastname: Couet
authors.forename: R
authors.initials: R
authors.lastname: Laroche
authors.forename: J J
authors.initials: JJ
authors.lastname: Floch
authors.forename: B
authors.initials: B
authors.lastname: Istin
authors.forename: J B
authors.initials: JB
authors.lastname: Fourtillan
authors.forename: J F
authors.initials: JF
authors.lastname: Sauniere
mesh_terms: D000293:Adolescent; D000328:Adult; D004318:Doxycycline / Q000097:blood / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011803:Quinine / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D011803:Quinine; D004318:Doxycycline