title: Evidence from in vitro studies that dihydroorotate dehydrogenase may be a source of toxic oxygen species.
authors.affiliation: Institut für Physiologische Chemie, Philipps-Universität, Marburg, F.R.G.
authors.forename: G
authors.initials: G
authors.lastname: Lakaschus
authors.forename: H
authors.initials: H
authors.lastname: Krüger
authors.forename: D
authors.initials: D
authors.lastname: Heese
authors.forename: M
authors.initials: M
authors.lastname: Löffler
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology; D002850:Chromatography, Gel; D000090722:Dihydroorotate Dehydrogenase; D004591:Electrophoresis, Polyacrylamide Gel; D006861:Hydrogen Peroxide / Q000378:metabolism; D007425:Intracellular Membranes / Q000201:enzymology; D007700:Kinetics; D051379:Mice; D008928:Mitochondria / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology*; D010088:Oxidoreductases / Q000302:isolation & purification / Q000378:metabolism*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D010100:Oxygen / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D013367:Submitochondrial Particles / Q000201:enzymology; D013552:Swine
chemical_list: D000090722:Dihydroorotate Dehydrogenase; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; D010100:Oxygen