Effects of [des-Tyr-D-Phe3]beta-casomorphin (2-5) on sleep pattern in rats.
The effects of the antidepressant-like acting peptide [des-Tyr-D-Phe3]beta-casomorphin(2-5) (Pro-D-Phe-Pro-Gly, BCH-325) on sleep were studied in rats. The rats received subcutaneous injections of BCH-325 in acute experiments (doses: 4, 20, 100, 500 and 2500 nmol/kg) and in a 10-day chronic experiment (50 nmol/kg/day). Acute administration of 20 and 100 nmol/kg enhanced wakefulness, 500 and 2500 nmol/kg enhanced paradoxical sleep, and 4 nmol/kg had no effect. Chronic administration resulted in an increase of paradoxical sleep during the first 5 days of drug treatment. Thus the sleep effects of BCH-325 differ from those of typical antidepressants and other psychotropic drugs.
Schulz
S
S
Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, Germany.
Diedrich
M
M
Wetzel
W
W
Matthies
H
H
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000494:pharmacology*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects*; D014851:Wakefulness / Q000187:drug effects
D000928:Antidepressive Agents; D004723:Endorphins; D010446:Peptide Fragments; C059556:beta-casomorphin, des-Tyr-