The in vivo effects of recombinant human erythropoietin on cisdiamminodichloroplatinum-induced anemia in golden Syrian hamsters.
Recombinant human erythropoietin given subcutaneously is able to accelerate hematopoietic recovery in hamsters affected by cisplatin-induced anemia, increasing hemoglobin and hematocrit levels. The increase in hemoglobin and hematocrit levels. The increase in hemoglobin and hematocrit levels is not accompanied by an increase of platelet or granulocyte counts in the peripheral blood. However, an increase in the marrow concentration of burst and colony forming units--erythroid (BFU-E, CFU-E) is observed after recombinant human erythropoietin treatment. This increase in the concentration of marrow erythroid progenitors was accompanied by an increase in the percentage of these stem cells in DNA synthesis as assessed by exposure to ARA-Cyt. Recombinant human erythropoietin seems highly effective in ameliorating and/or preventing cisplatin-induced anemia in experimental animals.
Gebbia
V
V
Section of Oncology, University of Palermo, Italy.
Palmeri
S
S
Valenza
R
R
Rausa
L
L
Citarrella
P
P
D000740:Anemia / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002945:Cisplatin / Q000633:toxicity*; D003114:Colony-Forming Units Assay; D006224:Cricetinae; D004921:Erythropoietin / Q000627:therapeutic use*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000473:pathology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008647:Mesocricetus; D011994:Recombinant Proteins / Q000627:therapeutic use
D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin; D002945:Cisplatin