title: [Influence of the speed of spheronization on the physical properties and dissolution availability of theophylline minigranules prepared by extrusion-spheronization].
abstract: From the minigranules of the theophylline-based that prepared by extrusion-spheronization, the authors have envisaged the study of one of the parameters of operation (spheronizer speed) on the physical properties and lyoavailability of the active ingredient. It emerges that there is a clear influence of that parameters on the particle size distribution, the hardness, the friability, the density and the lyoavailability.
authors.affiliation: Université de Montpellier I, Faculté de Pharmacie, Laboratoire de Pharmacie Galénique, Pharmacotechnie et Biopharmacie.
authors.forename: L
authors.initials: L
authors.lastname: Rahman
authors.forename: D
authors.initials: D
authors.lastname: Gaudy
authors.forename: B
authors.initials: B
authors.lastname: Bataille
authors.forename: M
authors.initials: M
authors.lastname: Jacob
authors.forename: A
authors.initials: A
authors.lastname: Puech
mesh_terms: D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods*; D011208:Powders; D012995:Solubility; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D011208:Powders; D013806:Theophylline
vernacular_title: Etude de l'influence de la vitesse de sphéronisation sur les propriétés physiques et la lyodisponibilité de minigranules de théophylline obtenus par extrusion-sphéronisation.