[Malaria in the republic of São Tomé and Principe. Epidemiologic evaluation and chemoresistance of P. falciparum].
The authors report the results of a valuation of paludometric indices during mai 1990 in Democratic São Tomé e Príncipe Republic (RDSTP). These investigations (parasitic index and spleen index) suggest that malaria is mesoendemic in these area. Plasmodium susceptibility to chloroquine at posology of 25 mg/kg per os was evaluated (WHO standard 7 days field test). Among 58 children, ranging from 5 to 11 years old, resistance at level R I was observed in 9% of cases, at level R II in 14%. Among 10 strains of P. falciparum, 9 were chloroquine resistant in vitro. 2 strains were also less sensible to quinine.
Martet
G
G
Hôpital d'instruction des Armées A. Laveran, Service de Biologie clinique, Marseille.
Da Conceicao
S
S
Cordoliani
G
G
Delolme
H
H
Raphenon
G
G
Hovette
P
P
Doury
J C
JC
Baudon
D
D
Touze
J E
JE
Lecamus
J L
JL
D000367:Age Factors; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D001266:Atlantic Islands / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000453:epidemiology*; D008297:Male; D015767:Mefloquine / Q000494:pharmacology; D010616:Phenanthrenes / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000494:pharmacology; D012621:Seasons; D012737:Sex Factors; D013163:Splenomegaly
D000962:Antimalarials; D010616:Phenanthrenes; D002738:Chloroquine; D011803:Quinine; C023768:halofantrine; D015767:Mefloquine
Le paludisme en république de São Tomé et Principe. Evaluation épidémiologique et chimiorésistance de P. falciparum.