[Effect of L-carnitine supplementation on lipid metabolism of renal failure, dialysis-dependent children and adolescents].
In six renally insufficient children and adolescents (age: 8-21 years) on hemodialysis the effect of L-carnitine supplementation at two dose levels (10 mg/kg/d vs. 100 mg/kg/d) on parameters of lipid metabolism was investigated. L-Carnitine substitution was carried out over four weeks per dose level. Under this regime a significant increase of the serum carnitine concentration occurred together with a decrease in the AC/FC-ratio (x: 1.59 to x:0.83). During the same period a significant decrease in serum triglyceride levels as well as an increase in serum HDL-cholesterol were observed. An inverse correlation (r = -0.63; p less than 0.0008) was found between HDL-cholesterol and the AC/FC-ratio. L-carnitine supplementation and its increasing effect on HDL-cholesterol in patients with renal insufficiency may be considered as antiatherogenic.
Böhles
H
H
Zentrum der Kinderheikunde; Johann Wolfgang Goethe-Universität, Frankfurt/Main.
Michalk
D
D
von Wendt-Göknur
E
E
D000293:Adolescent; D002331:Carnitine / Q000008:administration & dosage*; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D002331:Carnitine
Der Einfluss einer L-Carnitin-Supplementierung auf den Lipidstoffwechsel niereninsuffizienter, dialysepflichtiger Kinder und Jugendlicher.