[The response of human lymphocytes to Staphylococcus aureus peptidoglycan in a system of opsonic cooperation].
Interaction of lymphocytes with S. aureus peptidoglycan treated with normal human serum and its fractions was studied on the basis of luminol-dependent chemiluminescent reaction. Treatment with whole serum led to the considerable increase and acceleration of lymphocytic reactions. The opsonic effect mainly depended on antibodies and complement, the contribution of other opsonins (which could be partially attributed to fibronectin) did not exceed 30%. IgG and fibronectin in concentrations, similar to their concentration in normal human plasma, enhanced the reactions 3.4 +/- 0.3 (p less than 0.05) and 1.5 +/- 0.005 (p greater than 0.05) times, respectively. The problem of the intrapopulation profile of opsonic-lymphocytic reactions and their role in the system of cell-mediated and humoral interactions is discussed.
Maianskiĭ
A N
AN
Osipov
O A
OA
Astaf'ev
D G
DG
D000328:Adult; D005353:Fibronectins / Q000494:pharmacology; D006801:Humans; D008163:Luminescent Measurements; D008165:Luminol; D008211:Lymphocyte Cooperation / Q000187:drug effects / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D009895:Opsonin Proteins / Q000187:drug effects / Q000276:immunology*; D010457:Peptidoglycan / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*
D005353:Fibronectins; D009895:Opsonin Proteins; D010457:Peptidoglycan; D008165:Luminol
Otvet limfotsitov cheloveka na peptidoglikan Staphylococcus aureus v sisteme opsonicheskoĭ kooperatsii.