Evidence from in vitro studies that dihydroorotate dehydrogenase may be a source of toxic oxygen species.
Lakaschus
G
G
Institut für Physiologische Chemie, Philipps-Universität, Marburg, F.R.G.
Krüger
H
H
Heese
D
D
Löffler
M
M
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology; D002850:Chromatography, Gel; D000090722:Dihydroorotate Dehydrogenase; D004591:Electrophoresis, Polyacrylamide Gel; D006861:Hydrogen Peroxide / Q000378:metabolism; D007425:Intracellular Membranes / Q000201:enzymology; D007700:Kinetics; D051379:Mice; D008928:Mitochondria / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology*; D010088:Oxidoreductases / Q000302:isolation & purification / Q000378:metabolism*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D010100:Oxygen / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D013367:Submitochondrial Particles / Q000201:enzymology; D013552:Swine
D000090722:Dihydroorotate Dehydrogenase; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; D010100:Oxygen