[Nitrates in the drinking water and cancer].
Nitrates originating from food and particularly from water are supposedly precursors of carcinogenic N-nitroso compound (NOC) formed within the organism. According to Correa and al. these transformations could be a consequence of bacterial gastric pullulation resulting from certain hypochlorhydric conditions. Much epidemiological research has tried to establish a relationship between exposure to nitrates in drinking water and cases of gastric cancer. The present article deals with research into this relationship in France, in a region where the rate of nitrates in water supplies is among the highest. Death statistics (from cancers of the digestive and urinal tracts) are issued by INSERM and these of the population by INSEE. Towns are classified according to nitrate concentration and the number of deaths is established according to tumour detection by sex and age. Research into death rate divergencies is found by chi 2 and the correlated coefficient. The average relative risk for any age group is calculated for all types of cancer. Research on frequency is carried out from tumour records. Comparative frequency rates are established by direct standardisation according to the structural age of any one European population. Results are analysed in relation to (1) mortality rates and (2) incidence rates. (1) None of the cancers studied, of the digestive or urinary systems, whatever the age on sex, is significantly linked to the quantity of nitrates in water supplies. When all these cancers are taken into account, the death rate does not vary significantly for increasing concentration of nitrates. Towns exceeding the maximum concentration permitted by law do not have a higher mortality rate than other towns.(ABSTRACT TRUNCATED AT 250 WORDS)
Leclerc
H
H
Faculté de Médecine, Lille.
Vincent
P
P
Vandevenne
P
P
D000328:Adult; D000368:Aged; D004067:Digestive System Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000401:mortality; D005069:Evaluation Studies as Topic; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000009:adverse effects* / Q000032:analysis; D012307:Risk Factors; D014571:Urologic Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000401:mortality; D014881:Water Supply / Q000032:analysis / Q000592:standards*
D009566:Nitrates
Nitrates de l'eau de boisson et cancer.