title: Single photon emission computed tomography in children with idiopathic seizures.
abstract: Single photon emission computed tomography (SPECT) with N-isopropyl-p[123I]-iodoamphetamine (IMP), X-ray computed tomography (X-CT), and magnetic resonance imaging (MRI) were performed in 20 children with idiopathic seizures. In children with idiopathic seizures, SPECT could detect the abnormal sites at the highest rate (45%) compared with CT (10%) and MRI (12%), but the abnormal sites on SPECT correlated poorly with the foci on electroencephalograph (EEG). Idiopathic epilepsy with hypoperfusion on SPECT was refractory to treatment and was frequently associated with mental and/or developmental retardation. Perfusion defects on SPECT scans probably affect the development and maturation of the brain in children.
authors.affiliation: Department of Radiology, Kumamoto University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: A
authors.initials: A
authors.lastname: Kojima
authors.forename: O
authors.initials: O
authors.lastname: Shimomura
authors.forename: R
authors.initials: R
authors.lastname: Kinoshita
authors.forename: S
authors.initials: S
authors.lastname: Tomiguchi
authors.forename: K
authors.initials: K
authors.lastname: Taku
authors.forename: T
authors.initials: T
authors.lastname: Miike
mesh_terms: D000293:Adolescent; D000328:Adult; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000150:complications; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine