Carcinogenic effects of bis(2,3-dibromopropyl)-phosphate in Wistar rats.
Four groups of 40 Wistar rats of each sex per dose level were fed diets containing 0, 80, 400 or 2000 ppm of the magnesium salt of bis(2,3-dibromopropyl)phosphate (Bis-BP) for 24 months. A high incidence of tumours was induced, in both sexes, in the digestive system. Tumours included papillomas and adenocarcinomas of the tongue, oesophagus and forestomach, adenocarcinomas of the intestine and hepatocellular adenomas (neoplastic nodules) and carcinomas. Pre-terminal mortalities were associated with an increased incidence of forestomach papillomas in both sexes, adenocarcinomas of the small intestine in male rats and increased incidence of hepatocellular carcinomas in females. The data suggest that Bis-BP is a more potent proximate carcinogen than tris-(2,3-dibromopropyl)phosphate (Tris-BP).
Takada
K
K
Division of Toxicology, National Institute of Hygienic Sciences, Tokyo, Japan.
Naito
K
K
Kobayashi
K
K
Tobe
M
M
Kurokawa
Y
Y
Fukuoka
M
M
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004947:Esophagus / Q000187:drug effects / Q000473:pathology; D005260:Female; D006965:Hyperplasia; D007414:Intestinal Neoplasms / Q000139:chemically induced; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D009153:Mutagens / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009929:Organ Size / Q000187:drug effects; D009928:Organ Specificity; D010755:Organophosphates / Q000009:adverse effects*; D010212:Papilloma / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects / Q000473:pathology
D009153:Mutagens; D010755:Organophosphates; C035185:bis(2,3-dibromopropyl)phosphate