[Changes in the activity of antioxidant enzymes and level of lipid peroxidation in the embryo brain tissue during prenatal action of ethanol].
Catalase, superoxide dismutase (SOD) activity and level of lipid peroxidation in embryo brain of 13-17-th day were evaluated during ethanol consumption by pregnant rats. The level of lipid peroxidation was more higher in alcohol groups, than in control groups. At the same time the reduced glutathione content was decreased by 13% in the brain of 15-th day embryos under the same conditions. One can draw a conclusion that the elevated level of lipid peroxidation may be a consequence of activated free radical mechanisms or consequence of reduced activity of a non-enzymatic antioxidant system.
Burmistrov
S O
SO
Kotin
A M
AM
Borodkin
Iu S
IuS
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism*; D063647:Fetal Alcohol Spectrum Disorders / Q000201:enzymology / Q000378:metabolism*; D005865:Gestational Age; D015227:Lipid Peroxidation; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*
D002374:Catalase; D013482:Superoxide Dismutase
Izmenenie aktivnosti fermentov antioksidantnoĭ zashchity i urovnia perekisnogo okisleniia lipidov tkani mozga émbrionov pri prenatal'nom deĭstvii étanola.