Interferon (IFN) alpha inhibits cell proliferation of UWOV2 cells without down-regulation of transferrin receptors.
It has been suggested that growth inhibition of cells by interferons may be mediated through interferon induced down-regulation of transferrin receptor expression. We describe a continuously growing cell line UWOV2 (pf) which expresses cell surface transferrin receptor but is able to grow in the absence of transferrin. This cell line is sensitive to the growth inhibitory effects of interferon alpha. Interferon alpha induced growth inhibition is not, however, accompanied by modulation of transferrin receptor expression suggesting that transferrin receptor modulation is not an essential component of the growth inhibitory effect of interferons.
Bezwoda
W R
WR
Department of Medicine, Hematology/Oncology, University of the Witwatersrand Medical School, Parktown, Johannesburg, South Africa.
Golombick
T
T
Mansoor
N
N
D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D015536:Down-Regulation; D005434:Flow Cytometry; D016898:Interferon-alpha / Q000494:pharmacology*; D011990:Receptors, Transferrin / Q000187:drug effects*
D016898:Interferon-alpha; D011990:Receptors, Transferrin