title: A comparative study of the biological properties of some sea snake venoms.
abstract: 1. The protease, phosphodiesterase, alkaline phosphomonoesterase, L-amino acid oxidase, acetylcholinesterase, phospholipase A, 5'-nucleotidase, hyaluronidase, arginine ester hydrolase, procoagulant, anticoagulant and hemorrhagic activities of ten samples of venoms from seven taxa of sea snakes were examined. 2. The results show that venoms of sea snakes of both subfamilies of Hydrophiinae and Laticaudinae are characterized by a very low level of enzymatic activities, except phospholipase A activity and, for some species, hyaluronidase activity. 3. Because of the low levels of enzymatic activities and the total lack of procoagulant and hemorrhagic activities, venom biological properties are not useful for the differentiation of species of sea snakes. Nevertheless, the unusually low levels of enzymatic activities of sea snake venoms may be used to distinguish sea snake venoms from other elapid or viperid venoms.
authors.affiliation: Department of Biochemistry, University of Malaya, Lumpur, Malaysia.
authors.forename: N H
authors.initials: NH
authors.lastname: Tan
authors.forename: G
authors.initials: G
authors.lastname: Ponnudurai
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D000594:Amino Acid Oxidoreductases / Q000378:metabolism; D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D006470:Hemorrhage / Q000139:chemically induced; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D051379:Mice; D010741:Phospholipases A / Q000378:metabolism; D012623:Seawater; D012910:Snake Venoms / Q000378:metabolism* / Q000633:toxicity; D012911:Snakes; D013045:Species Specificity
chemical_list: D012910:Snake Venoms; D000594:Amino Acid Oxidoreductases; C019724:arginine esterase; D002265:Carboxylic Ester Hydrolases; D010741:Phospholipases A; D000110:Acetylcholinesterase; D015720:5'-Nucleotidase; D006821:Hyaluronoglucosaminidase; D010450:Endopeptidases