title: [Rheologic and coagulational disorders and their correction with heparin in patients with autoimmune thrombocytopenic purpura treated with antilymphocytic globulin].
abstract: Rheologic and hemocoagulation parameters were studied in 26 patients with autoimmune thrombocytopenic purpura (AITP). It has been shown that disorders in red blood cell rheologic properties detected in these patients aggravate the hemostasis disturbances and promote the development of disseminated intravascular blood coagulation (DIVBC). After infusion of antilymphocytic globulin (ALG) to 20 AITP patients improvement of general condition, as well as positive changes in the rheologic and hemocoagulation parameters were recorded in 15 of them. However, progressing DIVBC syndrome was observed in 5 patients, rheologic shifts being in the basis of its mechanism. To prevent or correct arising disorders, besides ALG infusions, heparin administration was used in a dose of 2000 IU/day. Rheologic and coagulation parameters significantly improved, hemorrhagic symptoms disappeared. Heparin administered in time to AITP patients who received ALG will permit conduction of a full course of treatment with this preparation.
authors.forename: S S
authors.initials: SS
authors.lastname: Bessmel'tsev
authors.forename: Z D
authors.initials: ZD
authors.lastname: Fedorova
authors.forename: K M
authors.initials: KM
authors.lastname: Abdulkadyrov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000188:drug therapy*; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000188:drug therapy*; D012212:Rheology
chemical_list: D000961:Antilymphocyte Serum; D006493:Heparin
vernacular_title: Reologicheskie i gemokoagulĭatsionnye narusheniia u bol'nykh autoimmunoĭ trombotsitopenicheskoĭ purpuroĭ, poluchavshikh antilimfotsitarnyĭ globulin, i korresktsiia ikh geparinom.