Chronic continuous nicotine treatment causes decreased burst firing of nigral dopamine neurons in rats partially hemitransected at the meso-diencephalic junction.
Chronic continuous administration of nicotine (0.125 mg/kg/h, 14 days) to male Sprague-Dawley rats with a partial hemitransection at the meso-diencephalic junction caused a significant reduction in burst firing of remaining dopamine (DA) neurons in the zona compacta, substantia nigra, whereas neither the firing rate nor the number of spontaneously active DA cells per track were altered in comparison with saline-treated, hemitransected controls. The reduced functional activity of the remaining DA cells subjected to nicotine treatment provides a physiological correlate to the previously observed, reduced DA utilization in these neurons. It may also help to explain the increased nigral DA cell survival found after chronic nicotine treatment in similar lesion experiments.
Grenhoff
J
J
Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Janson
A M
AM
Svensson
T H
TH
Fuxe
K
K
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004027:Diencephalon / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D007124:Immunoenzyme Techniques; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects*; D013997:Time Factors
D009538:Nicotine; D004298:Dopamine