The effect on serum lipid concentrations of a prolonged infusion of propofol--hypertriglyceridaemia associated with propofol administration.
Serum concentrations of triglyceride, cholesterol and high density lipoprotein-cholesterol (HDL-cholesterol) were measured in an ICU patient after he had received a 10-day continuous infusion of propofol. No additional parenteral lipid was given in the 72 h prior to initial sampling, but a total of 71 of 10% intralipid had been administered over the remaining 7 days. The total cumulative dose of propofol was 66.1 g (range 0.7-6.4 mg kg-1 h-1). There was no visual appearance of lipaemia. Both the serum triglyceride and cholesterol concentrations increased (triglyceride level increased to 4 times normal whereas the cholesterol elevation was minimal). The HDL-cholesterol concentration decreased. At 72 h after discontinuing the infusion of propofol the triglyceride level remained elevated, the cholesterol concentration had returned to normal and the HDL-cholesterol concentration remained unchanged. The implications of hypertriglyceridaemia are discussed.
Eddleston
J M
JM
Intensive Care Unit, Withington Hospital, Manchester, UK.
Shelly
M P
MP
D000293:Adolescent; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D002149:Energy Intake; D005217:Fat Emulsions, Intravenous / Q000592:standards; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000139:chemically induced*; D007262:Infusions, Intravenous; D008297:Male; D009104:Multiple Trauma / Q000188:drug therapy* / Q000628:therapy; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D005217:Fat Emulsions, Intravenous; D014280:Triglycerides; D002784:Cholesterol; D015742:Propofol