Splenic immunomodulation with swimming-induced stress in rats.
In order to determine the effects of swimming-induced stress, young male Wistar rats swam for a single session of 2 h duration, or for one 2-h session a day for five consecutive days. The absolute number of splenic mononuclear cells and the in vitro proliferation of mitogen-stimulated (PHA) T lymphocytes were studied. A single swimming session did not significantly diminish the number of splenic mononuclear cells, but it did significantly reduce splenic T-lymphocyte proliferation. This effect on T-lymphocyte proliferation was significantly blocked, in part, by subcutaneous injection of naltrexone before a swimming session. It was not significantly blocked by pre-exercise oral administration of aminoglutethimide. Repeated swimming sessions induced no significant changes in immune parameters. In conclusion, these data suggest that immunosuppression seen with a single swimming-induced stress period may partly be due to endogenous opioids, and that repetition of the swimming session reduced swimming-induced immunomodulation.
Ferry
A
A
Laboratoire de Physiologie des Adaptations, Université René Descartes, Paris, France.
Weill
B
B
Amiridis
I
I
Laziry
F
F
Rieu
M
M
D000616:Aminoglutethimide / Q000008:administration & dosage; D000818:Animals; D004723:Endorphins / Q000502:physiology; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D009271:Naltrexone / Q000008:administration & dosage; D015213:Neuroimmunomodulation / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology*; D013550:Swimming; D013601:T-Lymphocytes / Q000276:immunology*
D004723:Endorphins; D000616:Aminoglutethimide; D009271:Naltrexone