Effect of felodipine on histamine and adenosine induced bronchoconstriction in patients with asthma.
The effect of felodipine, a new selective calcium antagonist, was assessed on histamine and adenosine monophosphate (AMP) induced bronchoconstriction in 9 mild atopic asthmatics. Felodipine did not alter the baseline FEV1, but showed a small significant inhibitory effect upon histamine and AMP induced bronchoconstriction.
Ghosh
S K
SK
Department of Respiratory Medicine, Western Infirmary, Glasgow, Scotland, UK.
Rafferty
P
P
D000249:Adenosine Monophosphate / Q000494:pharmacology; D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D016084:Bronchoconstriction / Q000187:drug effects*; D004311:Double-Blind Method; D015736:Felodipine / Q000008:administration & dosage / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008297:Male
D000249:Adenosine Monophosphate; D006632:Histamine; D015736:Felodipine