Oral amino acids and gastric emptying: an investigation of the mechanism of levodopa-induced gastric stasis.
To investigate possible mechanisms of levodopa-induced gastric stasis, we have studied the effect of other amino acids on gastric emptying. The large neutral amino acid tryptophan delays gastric emptying in the dog at molar concentrations below those required to stimulate duodenal osmoreceptors. In healthy volunteers, we have shown that neither tryptophan nor the small neutral amino acid glycine delayed gastric emptying when given in concentrations similar to those of levodopa which produce gastric stasis. The study suggests that levodopa does not inhibit gastric emptying by an effect on duodenal amino acid receptors or via osmoreceptors.
Waller
D G
DG
Clinical Pharmacology Group, University of Southampton, Southampton General Hospital.
Usman
F
F
Renwick
A G
AG
Macklin
B
B
George
C F
CF
D000082:Acetaminophen / Q000097:blood / Q000494:pharmacology; D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005998:Glycine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D014364:Tryptophan / Q000008:administration & dosage / Q000494:pharmacology*
D000082:Acetaminophen; D007980:Levodopa; D014364:Tryptophan; D005998:Glycine