[An experimental infection of the seal Phoca sibirica with the morbilli virus].
A Baikal seal (Phoca sibirica) was experimentally infected with Baikal seal morbillivirus (BSMV) isolated from Baikal seals during an epizootic in 1987-1988. The seal was infected with BSMV with an infectious titer of 10(7.0) TCD50/ml, and daily observations of the animal clinical condition were made. The virus-specific antibodies in the seal serum were determined by ELISA and virus neutralization test. The clinical picture showed a mild infection. The ELISA-active antibodies were detected 10 days postinfection and reached the maximum in 20 days. Virus-neutralizing antibodies were detected in 16 days after infection, reached the maximum titer of 1:640 in 20 days and remained at this level for 39 days (the observation period). These data indicate that BSMV can induce a disease in the natural host with production of virus-neutralizing antibodies. The results of this work and the earlier reports show that the epizootic in Baikal seals was induced by BSMV.
Titenko
A M
AM
Borisova
T I
TI
Beĭm
A M
AM
Novozhilov
S S
SS
Kudelin
V N
VN
Zorin
V L
VL
Kumarev
V P
VP
Kolesnik
V S
VS
D000820:Animal Diseases / Q000175:diagnosis; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000918:Antibody Specificity; D008457:Measles / Q000175:diagnosis*; D008459:Measles virus / Q000276:immunology; D046048:Seals, Earless / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral
Eksperimental'noe infitsirovanie nerpy Phoca sibirica morbillivirusom.