[Effects of ethanol and limontar in the antenatal period of development on lipid peroxidation process and antioxidant defense system in the brain and liver tissue of fetal and newborn rats].
The process of lipid peroxidation and the system of antioxidant defense in brain and liver of fetuses on the 20th day of gestation and 1 day old rats after antenatal exposure to ethanol and limontar were studied. It was shown that antenatal exposure to ethanol led to activation of the process of lipid peroxidation in brain and to inhibition of of the enzyme system of antioxidant defense in liver of fetal and newborn rats. Limontar promoted the normalization of both the process of lipid peroxidation and the system of antioxidant defense.
Bykova
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Zhukova
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D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005865:Gestational Age; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats
D000975:Antioxidants; D000431:Ethanol
Deĭstvie etanola i limontara v antenatal'nom periode razvitiia na protsess perekisnogo okisleniia lipidov i sistemu antioksidantnoĭ zashchity v tkani mozga i pecheni plodov i novorozhdennykh krys.