title: Emergency department analgesia without narcotics for adults with acute sickle cell pain crisis: case reports and review of crisis management.
abstract: Vaso-occlusive crises are one of the most debilitating features of sickle cell disease. There appears to be no standardization of care for adults with pain crisis, and some commonly utilized regimens, such as those employing intramuscular meperidine, are pharmacologically unsound. Parenteral narcotic use may be associated with respiratory compromise acutely and with dependence over the long term, but nonopioid preparations are often unsatisfactory in relieving pain. We have recently enjoyed success with a combination of a parenteral nonsteroidal anti-inflammatory medication and an oral tricyclic antidepressant. We report four representative cases and review the salient points of the management of pain crisis in adult patients in the emergency department.
authors.affiliation: Division of Emergency Medicine, University of Mississippi Medical Center, Jackson 39216-4505.
authors.forename: C V
authors.initials: CV
authors.lastname: Pollack
authors.forename: D Y
authors.initials: DY
authors.lastname: Sanders
authors.forename: H W
authors.initials: HW
authors.lastname: Severance
mesh_terms: D000208:Acute Disease; D000328:Adult; D000698:Analgesia / Q000379:methods*; D000755:Anemia, Sickle Cell / Q000150:complications*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000929:Antidepressive Agents, Tricyclic