title: Ultrastructural morphology of ectoplacental cone trophoblasts of hamster embryos.
abstract: The invasiveness of trophoblast cells is well known, but it is not clear whether they achieve this property by being transformed to other cell types (like malignant ones) or remain benign. Trophoblasts, in culture, were studied ultrastructurally by examining the surface morphology of the cell vis-à-vis their cytoplasmic outgrowth, and the presence and/or absence of ruffling membranes, filopodia, microvilli, pinocytotic pits or bleb-like structures was observed. Results revealed formation of ruffling membranes only on the leading edge, a presence of slender filopodia and pinocytotic pits but an absence of microvilli and bleb-like structures, the characteristic features of a transformed cell. The study indicated that the trophoblast cells, in spite of being invasive, do not convert to any other cell type.
authors.affiliation: Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
authors.forename: R
authors.initials: R
authors.lastname: Shukla
authors.forename: P K
authors.initials: PK
authors.lastname: Mehrotra
authors.forename: S C
authors.initials: SC
authors.lastname: Maitra
authors.forename: V P
authors.initials: VP
authors.lastname: Kamboj
mesh_terms: D000818:Animals; D002462:Cell Membrane; D002478:Cells, Cultured; D003034:Coated Pits, Cell-Membrane; D006224:Cricetinae; D004622:Embryo, Mammalian; D008647:Mesocricetus; D010873:Pinocytosis; D010920:Placenta / Q000166:cytology*; D014327:Trophoblasts / Q000648:ultrastructure*