Behavior of calciotropic hormones in psoriasis.
This report was motivated by the finding that calciotropic hormones, except parathormone (PTH), do not show any response to 1a(OH)D3 therapy in psoriatic patients. These showed high basal whole PTH levels (127 +/- 38 pg/ml) which declined to 45 +/- 15 pg/ml after treatment (p less than 0.001) but did not correlate to calcemia values. Basal calcemia and calciuria were normal and rose with treatment (p less than 0.001 for both). Basal calcitonin and 25(OH)D3 were normal and did not change with treatment nor correlate to changes in calcemia. Due to the effect of 1-hydroxyvitamin D and calcemia on calcitonin and 25(OH)D, the lack of changes in the latter suggests a calciotropic hormone imbalance in psoriasis, which may be an etiologic factor in this entity.
Rico
H
H
Departamento de Medicina, Universidad de Alcalá de Henares, Madrid, España.
Robledo
A
A
Crabranes
J A
JA
Lopez-Bran
E
E
Hernandez
E R
ER
D000328:Adult; D002116:Calcitonin / Q000097:blood*; D002118:Calcium / Q000097:blood*; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy
D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D002116:Calcitonin; D002118:Calcium; C008088:alfacalcidol