title: The pathophysiology of acute optic neuritis. An association of gadolinium leakage with clinical and electrophysiological deficits.
abstract: Eighteen patients with acute optic neuritis underwent optic nerve magnetic resonance imaging (MRI) before and after injection of gadolinium-diethylene triamine pentacetic acid (Gd-DTPA). Ten were re-examined 4 weeks later. Leakage of Gd-DTPA across the blood-optic nerve barrier was a consistent finding in the acute lesion, and its presence was associated with abnormal visual acuity and colour vision, retro-ocular pain on eye movement, and afferent pupillary defect, and a reduced amplitude of the P100 component of the visual evoked potential. Gd-DTPA leakage had ceased in 9/11 nerves when restudied 4 wks later, and this evolution was associated with improved visual acuity and an increased P100 amplitude. Leakage is likely to reflect inflammation, and we conclude that the latter plays an important part in the production of conduction block and clinical deficit, and that its resolution is an important step in clinical remission from acute episodes of demyelination.
authors.affiliation: NMR Research Group, Institute of Neurology, London, UK.
authors.forename: B D
authors.initials: BD
authors.lastname: Youl
authors.forename: G
authors.initials: G
authors.lastname: Turano
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
authors.forename: A D
authors.initials: AD
authors.lastname: Towell
authors.forename: D G
authors.initials: DG
authors.lastname: MacManus
authors.forename: S G
authors.initials: SG
authors.lastname: Moore
authors.forename: S J
authors.initials: SJ
authors.lastname: Jones
authors.forename: G
authors.initials: G
authors.lastname: Barrett
authors.forename: B E
authors.initials: BE
authors.lastname: Kendall
authors.forename: I F
authors.initials: IF
authors.lastname: Moseley
mesh_terms: D000293:Adolescent; D000328:Adult; D004594:Electrophysiology; D005074:Evoked Potentials, Visual; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009902:Optic Neuritis / Q000175:diagnosis / Q000503:physiopathology*; D009942:Organometallic Compounds / Q000378:metabolism; D004369:Pentetic Acid / Q000378:metabolism
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA