title: Thermogenic effect of adrenaline: interaction with insulin.
abstract: The contribution of insulin (3.6 pmol.kg body mass-1.min-1) to adrenaline-induced (0.164 nmol.kg fat free mass-1.min-1) thermogenesis was studied in ten postabsorptive healthy volunteers using two sequential protocols. Variables considered were oxygen consumption as well as carbon dioxide production, heart rate, blood pressure, plasma concentrations of glucose, insulin, glycerol, free fatty acids, beta-HO-butyrate and lactate. Adrenaline increased plasma concentrations of glucose, glycerol, free fatty acids, and beta-HO-butyrate, and heart rate and metabolic rate during normo-insulinaemia [61.3 (SEM 6.6) pmol.l-1]. Similar effects were observed during hyperinsulinaemia [167.9 (SEM 18.7) pmol.l-1], but the effect of adrenaline on oxygen consumption was reduced. On average, metabolic rate increased by 12.9% during normo-insulinaemia and by 8.9% during hyperinsulinaemia. We concluded that relative hyperinsulinaemia resulted in decreased adrenaline-induced thermogenesis and therefore increased whole body anabolism.
authors.affiliation: Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Federal Republic of Germany.
authors.forename: O
authors.initials: O
authors.lastname: Selberg
authors.forename: S
authors.initials: S
authors.lastname: Schlaak
authors.forename: H J
authors.initials: HJ
authors.lastname: Balks
authors.forename: A
authors.initials: A
authors.lastname: von zur Mühlen
authors.forename: M J
authors.initials: MJ
authors.lastname: Müller
mesh_terms: D020155:3-Hydroxybutyric Acid; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001833:Body Temperature Regulation / Q000187:drug effects*; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005990:Glycerol / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007328:Insulin; D005990:Glycerol; D020155:3-Hydroxybutyric Acid; D004837:Epinephrine