[Anabolic action of prolactin on phosphatidylcholine metabolism in guinea pig adrenocorticocytes].
Isolated adrenocortical cells of guinea pigs whom injected with prolactin (PRL) during 3 days incorporated [3H] choline into phosphatidylcholine more intensively than those cells of animals in control. Labelling of intracellular pools of choline and phosphorylcholine remained unchanged, though a part of radioactivity represented by the water-soluble precursors decreased due to PRL influence. The rate of disappearance of labelled phosphatidylcholine in adrenocortical cells prelabelled with [3H] choline was lower in cells obtained from PRL-treated animals. The discharge of [3N] choline accumulated during prelabeling accelerated simultaneously. Rate of the phosphorylcholine radioactivity fall remained unchanged. The obtained data showed that prolonged influence of PRL caused a shift of the phosphatidylcholine metabolism to anabolism. That effect might be a part of the mechanism of proliferative PRL action in the adrenal cortex.
Sautin
Iu Iu
IuIu
Tron'ko
N D
ND
Kovzun
E I
EI
Mikosha
A S
AS
D000302:Adrenal Cortex / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D010713:Phosphatidylcholines / Q000378:metabolism*; D011388:Prolactin / Q000502:physiology*
D010713:Phosphatidylcholines; D011388:Prolactin
Anabolicheskoe deĭstvie prolaktina na metabolizm fosfatidilkholina v adrenokortikotsitakh morskikh svinok.