title: New surgical approach to overcome the inability of injured mammalian axons to grow within their environment.
abstract: We present a new method for creating conditions conductive to axonal growth in injured optic nerves of adult rabbits. The surgical approach consists of making a cavity in the adult rabbit optic nerve, into which a piece of nitrocellulose soaked with conditioned medium originating from regenerating fish optic nerves is implanted. In addition, daily irradiation (10 days, 5 min, 35 mW) with low energy He-Ne laser is carried out. Such a combined treatment may open a door to neurobiologists and clinicians, hoping to unravel the enigma of mammalian CNS regeneration.
authors.affiliation: Goldschleger Eye Research Institute, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Solomon
authors.forename: V
authors.initials: V
authors.lastname: Lavie
authors.forename: S
authors.initials: S
authors.lastname: Ben-Bassat
authors.forename: M
authors.initials: M
authors.lastname: Belkin
authors.forename: M
authors.initials: M
authors.lastname: Schwartz
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D003101:Collodion; D003131:Combined Modality Therapy; D003470:Culture Media; D006054:Goldfish / Q000502:physiology*; D053685:Laser Therapy; D009416:Nerve Regeneration / Q000187:drug effects / Q000528:radiation effects; D009900:Optic Nerve / Q000187:drug effects / Q000528:radiation effects / Q000601:surgery; D020221:Optic Nerve Injuries; D019736:Prostheses and Implants; D011817:Rabbits
chemical_list: D003470:Culture Media; D003101:Collodion