The growth hormone secretory response to growth hormone releasing factor in the developing rhesus monkey.
We studied the development of the GH response to growth hormone releasing hormone (GHRH) using two doses of GHRH. The newborns demonstrated higher baseline GH and responses to GHRH than animals of any older age. There was no difference noted between the rise in GH in male and female subjects with 10 mcg/kg vs 1 mcg/kg. Serum cortisol concentrations did not correlate with serum GH concentrations. These developmental patterns of serum GH are similar to those known in the human being.
Styne
D M
DM
Department of Pediatrics, University of California, School of Medicine, Davis 95616.
D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002406:Catheterization, Peripheral / Q000662:veterinary; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006854:Hydrocortisone / Q000097:blood; D007260:Infusion Pumps / Q000662:veterinary; D007262:Infusions, Intravenous / Q000662:veterinary; D008253:Macaca mulatta / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D012149:Restraint, Physical; D012727:Sex Characteristics
D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D006854:Hydrocortisone