[Effects of non-clostridial anaerobic infection on the course of chronic pulmonary tuberculosis in experimental animals].
Influence of non-clostridial anaerobic infection on the course of chronic pulmonary tuberculosis caused by intrapleural administration of BCG used in a vaseline-lanolin mixture was studied experimentally on guinea pigs. Administration of Bacteroides fragilis in the presence of a mild tuberculous inflammation aggravates the course of a specific process promoting pleural empyema development, increase in the size of pulmonary granuloma, extension of pathologic changes into the parenchymatous organs and aggravation of a nonspecific inflammatory reaction. Animals with mixed infection exhibited a longer duration and higher level of M. tuberculosis and B. fragilis excretion than those having a mono-infection. The findings suggest M. tuberculosis and B. fragilis synergism.
El'shanskaia
M P
MP
Golyshevskaia
V I
VI
Kazarova
T A
TA
D000818:Animals; D001442:Bacteroides Infections / Q000150:complications* / Q000382:microbiology; D001441:Bacteroides fragilis / Q000302:isolation & purification; D002908:Chronic Disease; D008168:Lung / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D011817:Rabbits; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000382:microbiology
Vliianie neklostridial'noĭ anaérobnoĭ infektsii na techenie khronicheskogo tuberkuleza legkikh v éksperimente.