On kynureninase activity.
1) In Mg-deficient rats, kynureninase activity is decreased. 2) p-Hydroxyphenylpyruvate inhibits kynureninase activity. 3) -SH groups in the apoenzyme of kynureninase play a very important role in the enzymatic reaction. 4) 3-Hydroxykynurenine may be a very important regulative metabolite in the 3-hydroxykynurenine----xanthurenic acid pathway.
Shibata
Y
Y
Department of Biochemistry, Aichi Medical University Nagakute, Japan.
Takeuchi
F
F
Tsubouchi
R
R
Haneda
M
M
Ohta
T
T
Nakatsuka
M
M
Nisimoto
Y
Y
Tamai
T
T
Nomura
S
S
Fujimoto
H
H
D000818:Animals; D001051:Apoenzymes / Q000378:metabolism; D052160:Benzothiazoles; D003545:Cysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D004228:Dithionitrobenzoic Acid / Q000494:pharmacology; D004229:Dithiothreitol / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006867:Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007737:Kynurenine / Q000031:analogs & derivatives* / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008274:Magnesium / Q000378:metabolism; D008297:Male; D010667:Phenylpyruvic Acids / Q000494:pharmacology; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan / Q000378:metabolism; D014443:Tyrosine / Q000494:pharmacology; D014977:Xanthurenates / Q000378:metabolism*
D001051:Apoenzymes; D052160:Benzothiazoles; D010667:Phenylpyruvic Acids; D014977:Xanthurenates; C010590:4-hydroxyphenylpyruvic acid; C005045:3-hydroxykynurenine; D007737:Kynurenine; C034680:S-(2-benzothiazolyl)cysteine; D014443:Tyrosine; C028330:xanthurenic acid; D011732:Pyridoxal Phosphate; D014364:Tryptophan; D004228:Dithionitrobenzoic Acid; D006867:Hydrolases; C021480:kynureninase; D008274:Magnesium; D003545:Cysteine; D004229:Dithiothreitol