title: [Status of liver mitochondria and rat tissue creatine kinase during administration of antivitamin K].
abstract: It has been shown that 16-18 days administration of antivitamin K (pelentan) leads to two-fold increase of prothrombin time in adult rats but does not influence the soluble brain, renal, heart, muscle and serum creatine kinase activity. No effect on metabolic function of isolated liver mitochondria has been found in contrast to the vitamin K deficient rats. Mitochondria were characterized by high value of respiration control; substance oxidation rates and internal mitochondrial Ca2+ content do not differ in the level from those of control animals. From the obtained results and data published in literature a conclusion can be drawn about only particular similarity (prothrombin time) between the antivitamin K administration and alimentary vitamin K deficit.
authors.forename: A A
authors.initials: AA
authors.lastname: Sokol'nikov
authors.forename: T V
authors.initials: TV
authors.lastname: Zharova
authors.forename: O V
authors.initials: OV
authors.lastname: Tiulina
authors.forename: V M
authors.initials: VM
authors.lastname: Kodentsova
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Leĭkin
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D003402:Creatine Kinase / Q000187:drug effects*; D005017:Ethyl Biscoumacetate / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects; D011517:Prothrombin Time; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005017:Ethyl Biscoumacetate; D003402:Creatine Kinase
vernacular_title: Sostoianie mitokhondriĭ pecheni i aktivnost' kreatinkinazy tkaneĭ krysy pri vvedenii antivitamina K.