Homogeneous 5-HT1D recognition sites in the human substantia nigra identified with a new iodinated radioligand.
The novel iodinated radioligand, serotonin-5-O-carboxymethyl-glycyl[125I] tyrosinamide, was used for binding studies with membranes of human substantia nigra. Evidence is provided for the existence in this tissue of a homogeneous population of recognition sites with the pharmacological profile of the 5-HT1D site.
Bruinvels
A T
AT
Sandoz Pharma Ltd., Basel, Switzerland.
Landwehrmeyer
B
B
Waeber
C
C
Palacios
J M
JM
Hoyer
D
D
D004151:Dipeptides; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000031:analogs & derivatives*; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism*
D004151:Dipeptides; D007457:Iodine Radioisotopes; D011985:Receptors, Serotonin; C072128:serotonin-O-carboxymethyl-Gly-Tyr; D012701:Serotonin