title: [Initial experiences with prostaglandin E1 and PGE1 prepared injections].
abstract: Between April and August 1989 we treated 50 patients with an erectile dysfunction. 23 patients (46%) had an organic, 17 (34%) a psychogenic and 7 patients (14%) a mixed origin of their impotence. In 3 patients the diagnosis has yet to be made. To induce pharmacological erections we used 20 micrograms of prostaglandin-E1 in a ready to use syringe. 64% (32 patients) achieved a full erection. Of the 18 patients insufficiently responding, 12 (67%) had an organic (in 11 patients vascular), 4 a psychogenic and 1 patient a mixed erectile dysfunction. In one patient the diagnosis has not been established at present. 14% (7) of the patients complained to have painful erections disturbing intercourse. The mean erection time was 2.5 hours (range 0.5-5.5). In one patient the intracavernous injection of prostaglandin-E1 resulted in a prolonged erection of more than seven hours, which was successfully treated by aspiration of blood from the corpora cavernosa and intracavernous injection of phenylephrine-hydrochloride. Nevertheless prostaglandin-E1 appears to be more physiological and to have less side-effects than papaverin-chloride.
authors.affiliation: Urologische Klinik, Kantonsspital Basel.
authors.forename: G
authors.initials: G
authors.lastname: Mattarelli
authors.forename: B
authors.initials: B
authors.lastname: Leibundgut
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage* / Q000009:adverse effects; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007267:Injections; D008297:Male; D010410:Penile Erection / Q000187:drug effects
chemical_list: D000527:Alprostadil
vernacular_title: Erste Erfahrungen mit Prostaglandin-E1 und PG-E1-Fertigspritzen.