title: Lactobacillus casei-induced polyarthritis in Lewis rats: histopathological scoring system for evaluation of anti-rheumatic drugs.
abstract: A histopathological scoring system which grades drug effects on cellular infiltration, pannus formation, cartilage degradation and bone resorption in L. casei-induced polyarthritis in rats is described. Reference anti-rheumatic and anti-inflammatory agents administered on days 2-60 after induction of arthritis were evaluated for effects on paw swelling weekly and graded histopathologic changes on day 60. This animal model affords a tool to evaluated therapeutic agents on the joint destruction resulting from chronic inflammation.
authors.affiliation: CIBA-GEIGY Corporation, Research Department, Summit, NJ 07901.
authors.forename: E M
authors.initials: EM
authors.lastname: O'Byrne
authors.forename: E D
authors.initials: ED
authors.lastname: Roberts
authors.forename: A S
authors.initials: AS
authors.lastname: Rubin
authors.forename: V
authors.initials: V
authors.lastname: Blancuzzi
authors.forename: D
authors.initials: D
authors.lastname: Wilson
authors.forename: N R
authors.initials: NR
authors.lastname: Hall
authors.forename: T J
authors.initials: TJ
authors.lastname: Lehman
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy* / Q000473:pathology; D001862:Bone Resorption / Q000188:drug therapy / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology; D002473:Cell Wall / Q000737:chemistry; D004341:Drug Evaluation; D005260:Female; D007596:Joints / Q000473:pathology; D007780:Lacticaseibacillus casei; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000893:Anti-Inflammatory Agents