Evidence for volume regulatory increase by Na-K-Cl co-transport in rat arterial smooth muscle.
A component of K efflux (86Rb as tracer) from rat femoral arterial smooth muscle was blocked by loop diuretics. Following hypertonic challenge with 100 mM-sucrose, K efflux increased but not in the presence of loop diuretics. This is taken as evidence for a volume regulatory increase mediated by Na-K-Cl co-transport.
Chipperfield
A R
AR
Department of Anatomy and Physiology, The University, Dundee.
Davis
J P
JP
Harper
A A
AA
D000818:Animals; D001158:Arteries / Q000378:metabolism; D002034:Bumetanide / Q000494:pharmacology; D002352:Carrier Proteins / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D009997:Osmotic Pressure; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012413:Rubidium / Q000378:metabolism; D028021:Sodium-Potassium-Chloride Symporters; D013395:Sucrose / Q000494:pharmacology
D002352:Carrier Proteins; D028021:Sodium-Potassium-Chloride Symporters; D002034:Bumetanide; D013395:Sucrose; D012413:Rubidium; D011188:Potassium