Effects of cisapride on the esophageal motor function of patients with progressive systemic sclerosis or mixed connective tissue disease.
In a double-blind crossover study lower esophageal sphincter pressure and distal esophageal motility were studied in 10 patients with progressive systemic sclerosis or mixed connective tissue disease, following a single intravenous dose of cisapride or placebo. The measurements were carried out under basal conditions and 30 min after intravenous administration of 10 mg cisapride or placebo. No effects on lower esophageal sphincter pressure or distal esophageal motility were observed.
Limburg
A J
AJ
Department of Medicine, University Hospital, Groningen, The Netherlands.
Smit
A J
AJ
Kleibeuker
J H
JH
D000328:Adult; D000368:Aged; D020117:Cisapride; D004311:Double-Blind Method; D004943:Esophagogastric Junction / Q000503:physiopathology; D004947:Esophagus / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000188:drug therapy / Q000503:physiopathology*; D010528:Peristalsis / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology*; D011312:Pressure; D012595:Scleroderma, Systemic / Q000188:drug therapy / Q000503:physiopathology*; D012702:Serotonin Antagonists / Q000494:pharmacology*
D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride