[The anti-inflammatory activity of structural analogs of the platelet-activating factor].
The pro- and anti-inflammatory activity of new structural analogues of the platelet-activating factor (PAF) was studied. It was found that three PAF analogues inhibit PAF-induced rat paw edema in a dose-dependent manner. The anti-inflammatory activity of one of the PAF analogues upon PAF- or carrageenan-induced inflammation was comparable or in some extent exceeded that of dexamethasone.
Melikiants
A G
AG
Kulikov
V I
VI
Koloskova
E E
EE
Kuznetsova
T I
TI
Dergousov
A A
AA
Lipatkina
L Iu
LIu
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D002351:Carrageenan; D003907:Dexamethasone / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007213:Indomethacin / Q000627:therapeutic use; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010972:Platelet Activating Factor; D003907:Dexamethasone; D002351:Carrageenan; D001241:Aspirin; D007213:Indomethacin
Protivovospalitel'naia aktivnost' strukturnykh analogov faktora aktivatsii trombotsitov.