[Increasing the radioprotective therapeutic efficacy of typhoid vaccine using sexta-anatoxin in combination with the antimetabolite methotrexate].
A typhoid vaccine with sexta-anatoxin delivered to mice 4.5-5 h after gamma-irradiation has a pronounced therapeutic effect: survival rate is 42% with radiation dose of 8.2 Gy (LD85/30) and 19% with radiation dose of 8.7 Gy (LD95/30). The vaccine of 2.5 and 5 mg/kg combined with methotrexate has a more pronounced therapeutic effect increasing the survival rate up to 65% (LD85/30) and up to 35-40% (LD95/30).
Deshevoĭ
Iu B
IuB
Martirosov
K S
KS
Andrianova
I E
IE
D000818:Animals; D004359:Drug Therapy, Combination; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D014121:Toxoids / Q000627:therapeutic use*; D014436:Typhoid-Paratyphoid Vaccines / Q000627:therapeutic use*
D011837:Radiation-Protective Agents; D014121:Toxoids; D014436:Typhoid-Paratyphoid Vaccines; D008727:Methotrexate
Povyshenie protivoluchevoĭ lechebnoĭ éffektivnosti briushno-tifoznoĭ vaktsiny s sekstaanatoksinom pri ee sochetannom primenenii s antimetabolitom--metotreksatom.