title: Wernicke's encephalopathy and alcohol-related disease.
abstract: A pilot study of 31 consecutive alcohol-related deaths over an 8-month period revealed the presence of histologically diagnosed Wernicke's encephalopathy in 17 cases. Analysis of the clinical records revealed that a disturbance of the mental state was the commonest finding and neurological signs were present in only 2 of the 17 cases (ataxia 1, peripheral neuropathy 1). Analysis of 22 ward admissions for Wernicke's encephalopathy during the same 8-month period revealed that the diagnosis is easily made when neurological deficits (ophthalmoplegia, ataxia) accompany mental changes and when Wernicke's encephalopathy is the predominant illness. In patients with established alcohol-related disease attention is often directed to the presenting illness so that Wernicke's encephalopathy may easily be overlooked as a cause of deterioration in the mental state in these patients. It is recommended that routine management of patients with alcohol-related disease should include thiamine even if neurological signs are absent.
authors.affiliation: Department of Medicine, University of Natal, Medical School, Durban, Republic of South Africa.
authors.forename: D P
authors.initials: DP
authors.lastname: Naidoo
authors.forename: A
authors.initials: A
authors.lastname: Bramdev
authors.forename: K
authors.initials: K
authors.lastname: Cooper
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications* / Q000473:pathology; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D013831:Thiamine / Q000627:therapeutic use; D014899:Wernicke Encephalopathy / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology
chemical_list: D013831:Thiamine