Investigating protein conformation, dynamics and folding with monoclonal antibodies.
Monoclonal antibodies with thoroughly characterized target specificities can be used as powerful probes of protein conformation. In addition to providing information on the relative arrangement of the domains in the native molecule, they can also be used to monitor both early and late stages of protein folding and conformational changes related to enzyme action.
Goldberg
M E
ME
CNRS, URA 1129, Université Paris 7, Unité de Biochimie, Cellulaire, Institut Pasteur, France.
D000911:Antibodies, Monoclonal; D001666:Binding Sites, Antibody; D004926:Escherichia coli / Q000201:enzymology; D008024:Ligands; D011487:Protein Conformation; D014367:Tryptophan Synthase / Q000737:chemistry*
D000911:Antibodies, Monoclonal; D008024:Ligands; D014367:Tryptophan Synthase