Cytokines. A unifying concept in the pathogenesis of clubbing.
Finger clubbing is a striking clinical sign associated with a large variety of diseases and syndromes. Although clubbing is poorly understood, we hypothesise that there is a final common pathway in the pathogenesis of clubbing by which there is increased growth of connective tissue and augmented blood flow mediated or stimulated by cytokines, which are either over-produced or poorly eliminated.
Yosipovitch
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G
Department of Medicine B, Beilinson Medical Center, Petah Tiqva, Israel.
Weinberger
A
A
D016207:Cytokines / Q000502:physiology*; D005385:Fingers; D005767:Gastrointestinal Diseases / Q000150:complications; D006228:Hand Deformities, Congenital / Q000150:complications* / Q000235:genetics; D006330:Heart Defects, Congenital / Q000150:complications; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000150:complications / Q000151:congenital; D009369:Neoplasms / Q000150:complications; D013577:Syndrome
D016207:Cytokines