title: Intracerebroventricular dermorphin, but not dermenkephalin, is epileptogenic in the rat.
abstract: The effects of intracerebroventricular administration of dermorphin (mu agonist) and dermenkephalin (delta agonist) were studied at the electrocorticographic (ECoG) and electromyographic (EMG) levels in free-moving rats. A very low dose of dermorphin (125 pmol) induced ECoG spiking, occasional myoclonic jerks, wet-dog shakes and catalepsy. In addition, electrical seizures were triggered with doses of 250 to 500 pmol. These signs were reversed by an i.p. injection of naloxone (1 mg kg-1). However, no epileptic-like phenomena were seen after administration of dermenkephalin up to 1 nmol. These results indicate that mu but not delta receptors are involved in the epileptogenic effect of intraventricularly administered opiates.
authors.affiliation: INSERM, Centre Paul Broca, Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Gioanni
authors.forename: D
authors.initials: D
authors.lastname: Goyon
authors.forename: J
authors.initials: J
authors.lastname: Prevost
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000502:physiology*; D004569:Electroencephalography; D004576:Electromyography; D004827:Epilepsy / Q000139:chemically induced* / Q000503:physiopathology; D066298:In Vitro Techniques; D007276:Injections, Intraventricular; D009842:Oligopeptides; D018847:Opioid Peptides; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009842:Oligopeptides; D018847:Opioid Peptides; C059567:deltorphin; C030058:dermorphin