title: Diamines interfere with the transport of L-ornithine in Ehrlich-cell plasma-membrane vesicles.
abstract: 1. L-Ornithine transport by plasma-membrane vesicles isolated from Ehrlich cells is Na(+)-independent and shows a saturable and a diffusional component. 2. Putrescine, histamine, 5-hydroxytryptamine and 2,3-diaminopropane at 55 microM concentration significantly inhibit 0.5 mM-L-ornithine transport at least for the first 10 min of incubation. 3. There is a trans-stimulatory effect of putrescine on L-ornithine transport.
authors.affiliation: Laboratorio de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Málaga, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Medina
authors.forename: J L
authors.initials: JL
authors.lastname: Urdiales
authors.forename: J M
authors.initials: JM
authors.lastname: Mates
authors.forename: I
authors.initials: I
authors.lastname: Núñez de Castro
authors.forename: F
authors.initials: F
authors.lastname: Sánchez-Jiménez
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D003959:Diamines / Q000494:pharmacology*; D005973:Glutamine / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D009952:Ornithine / Q000378:metabolism*; D011700:Putrescine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology
chemical_list: D003959:Diamines; D005973:Glutamine; D012701:Serotonin; C070006:1,2-diaminopropane; D006632:Histamine; D009952:Ornithine; D011700:Putrescine