[The immunomodulating properties of staphylotoxin].
The action of native staphylotoxin has been tested on T lymphocytes obtained from 21 healthy human donors. As revealed in this investigation, toxic action affects Fc-receptors to IgG, IgM and IgA. The dose-dependent effect of the preparation suggests its direct contacts with Fc-receptors of lymphocytic membranes. High doses of the toxin suppress the expression of Fc-receptors 6- to 12-fold, low doses of the toxin are capable of stimulating the expression of Fc gamma-receptors.
Bol'shakov
I N
IN
Kulaev
D V
DV
Kulak
V G
VG
Lopukhin
Iu M
IuM
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D011961:Receptors, Fc / Q000187:drug effects / Q000276:immunology; D012397:Rosette Formation; D013211:Staphylococcus aureus; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D001427:Bacterial Toxins; D011961:Receptors, Fc; C036117:staphylotoxin
Immunomoduliruiushchie svoĭstva stafilotoksina.