title: Vascularised nerve grafts.
abstract: Since Taylor (1976) successfully performed the first vascularised free nerve graft, experimental and clinical data have not provided conclusive support for the superiority of this method of repairing loss of nerve substance. Experimental work yields conflicting results. Histologic results are in favour of vascularised grafts but non-vascularised fascicular grafts placed in a healthy bed recover sufficient neovascularisation within a short period of time (four to six days). In the field of brachial plexus repair, vascularised grafts give consistent results. However, if thrombosis of the anastomoses occurs, the grafts fail completely. In our experience, vascularised nerve grafts used for repairing digital nerves and arteries, have a high rate of thrombosis. There are few potential donor sites. A nerve graft cannot be considered to be physiologically vascularised if it relies only on an artery or on an arterialised vein. Given the present state of immunosuppressant treatments, vascularised allografts are not yet appropriate. Therefore, vascularised nerve grafts have limited applications. In general it is preferable to repair the tissue bed so as to promote revascularisation of conventional nerve grafts.
authors.affiliation: Service de Chirurgie Plastique et Reconstructrice de l'Appareil Locomoteur, Centre Hospitalo-Universitaire de Nancy, Hôpital Jeanne d'Arc, Toul, France.
authors.forename: M
authors.initials: M
authors.lastname: Merle
authors.forename: G
authors.initials: G
authors.lastname: Dautel
mesh_terms: D000328:Adult; D001917:Brachial Plexus / Q000098:blood supply / Q000601:surgery*; D005543:Forearm Injuries / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D016067:Nerve Transfer / Q000379:methods; D011446:Prospective Studies; D011826:Radial Nerve / Q000601:surgery; D014459:Ulnar Nerve / Q000601:surgery