[Placental ultrastructure in disturbed antenatal development of fetus and pathogenesis of these disorders in women with different types of diabetes mellitus].
The paper is concerned with analysis of 819 electronograms of placenta in macrosomia, hypotrophy, diabetic phenopathy, and antenatal death of fetuses on the 37th-38th weeks of pregnancy in 39 women with different types of diabetes mellitus. Ultrastructural characterization of placenta was analyzed, as was its hormone-producing function and the infant condition at birth and a degree of maturity of his main functional systems. Discrepancy between morphofunctional criteria of chorionic ultrastructure and a period of gestation were revealed in diabetic women in abnormal antenatal development of a fetus and imperfect adaptive possibilities of an infant in the neonatal period. The results of investigation have shown that disorders of antenatal development, functional incompetence of the systems of fetal self-regulation, and imperfect adaptive possibilities of an infant seem to be associated with discordance of placental development and fetogenesis. The author puts forward a hypothesis that diabetic fetopathy results from dysfunction of the hypothalamo-hypophyseo-adrenal system, and metabolic derangement i fetal self-regulation, caused by trophoblastic morphofunctional pathology and inadequacy of chorionic compensatory reactions in women with diabetes mellitus.
Bobkov
V M
VM
D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D010920:Placenta / Q000648:ultrastructure*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000473:pathology*
Ul'trastruktura platsenty pri narvsheniiakh antenatal'nogo razvitiia ploda i patogenez étikh narusheniĭ u zhenshchin s razlichnymi tipami sakharnogo diabeta.