Effect of flomoxef on blood coagulation and alcohol metabolism.
The effect of flomoxef, a newly developed oxacephem antibiotic with an N-hydroxyethyltetrazolethiol (HTT) side chain, on blood coagulation and alcohol metabolism was compared with that of a series of cephalosporin antibiotics with N-methyltetrazolethiol (NMTT), thiadiazolethiol (TDT) or methylthiadiazolethiol (MTDT) side chains in position 3' of the cephalosporin nucleus known to cause hypoprothrombinemia and bleeding in patients who are malnourished, debilitated and/or of high age. A disulfiram-like effect caused by inhibition of aldehyde dehydrogenase was observed for NMTT-containing antibiotics. Studies were carried out on healthy volunteers and on rats. Eight-day treatment with 2 g flomoxef i.v. once or twice daily in five and six healthy male volunteers, respectively, did not cause any significant changes in prothrombin time (PT), coagulation factors II, VII, IX or X, in hepaplastin values or fibrinogen levels, activated partial thromboplastin time (APTT), platelet counts, bleeding time, or collagen- and ADP-induced platelet aggregation. Inhibition of vitamin K epoxide reductase was observed in rats treated with flomoxef, yet to a much lesser extent than observed for cephalosporins with NMTT, TDT or MTDT side chains. This defect was quickly normalized by vitamin K injection. There were no differences between oxacephem (1-O) and cephem (1-S) compounds with respect to effects on blood clotting and platelet aggregation. Flomoxef and its side chain HTT showed no influence on alcohol metbolism.
Uchida
K
K
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Matsubara
T
T
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology*; D000431:Ethanol / Q000378:metabolism*; D006801:Humans; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship; D014812:Vitamin K / Q000502:physiology
D002511:Cephalosporins; D014812:Vitamin K; D000431:Ethanol; C045693:flomoxef