Generally recognized as safe (GRAS) evaluation of 4-hexylresorcinol for use as a processing aid for prevention of melanosis in shrimp.
4-Hexylresorcinol (C12H18O2) is proposed for use as a processing aid for prevention of melanosis ("black spot") in shrimp and as an alternative to the currently approved sulfites. A safety evaluation was conducted to affirm, based upon scientific procedures, the generally recognized as safe ("GRAS") status of 4-hexylresorcinol for proposed use. The GRAS safety evaluation compiled, reviewed, and analyzed data on the following areas: chemical identity, analytical methodology, historical and proposed uses, functionality, and safety. The publicly available safety data on 4-hexylresorcinol cover a broad range of potential toxicity concerns including acute and subacute toxicity, subchronic toxicity, carcinogenicity, mutagenicity, and allergenicity. These studies, along with the aforementioned data, demonstrate that 4-hexylresorcinol presents no risk of toxicity at the levels proposed for treatment of shrimp, and the use of 4-hexylresorcinol as a processing aid to prevent melanosis in shrimp is GRAS.
Frankos
V H
VH
ENVIRON Corporation, Arlington, Virginia 22203.
Schmitt
D F
DF
Haws
L C
LC
McEvily
A J
AJ
Iyengar
R
R
Miller
S A
SA
Munro
I C
IC
Clydesdale
F M
FM
Forbes
A L
AL
Sauer
R M
RM
D000818:Animals; D033364:Decapoda; D006168:Guinea Pigs; D006604:Hexylresorcinol / Q000633:toxicity*; D006801:Humans; D008548:Melanosis / Q000517:prevention & control / Q000662:veterinary*; D051379:Mice; D051381:Rats
D006604:Hexylresorcinol