Effect of radical treatment on erythrocyte lipid peroxidation in Plasmodium vivax-infected malaria patients.
Elevated levels of thiobarbituric acid reactive substances and increased in vitro Heinz body formation in erythrocytes of Plasmodium vivax-infected malarial patients were observed. Radical treatment with chloroquine and primaquine increased the per cent maximal release of thiobarbituric acid reactive substances. Antioxidant enzymes, superoxide dismutase and catalase were decreased significantly in vivax malaria. Superoxide dismutase showed restoration of enzyme activity while catalase activity was increased significantly following therapy, suggesting an active involvement of free radical mechanism.
Mathews
S T
ST
Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, India.
Selvam
R
R
D000818:Animals; D002374:Catalase / Q000097:blood; D002738:Chloroquine / Q000627:therapeutic use*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006366:Heinz Bodies / Q000187:drug effects; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D016780:Malaria, Vivax / Q000097:blood* / Q000188:drug therapy; D008297:Male; D011319:Primaquine / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood; D013858:Thiobarbiturates / Q000378:metabolism
D013858:Thiobarbiturates; D002738:Chloroquine; D002374:Catalase; D013482:Superoxide Dismutase; C029684:thiobarbituric acid; D011319:Primaquine