Inhibitory effects of flavonoids on several venom hyaluronidases.
In vitro studies showed that the flavonoid aglycones apigenin, luteolin and kaempferol inhibited the hyaluronidase activity of five different venoms dose-dependently. They were also able to delay the venom action when injected into mice. Naringenin, catechin and flavonoid glycosides had no effect. The flavonoids with unsubstituted hydroxyl groups at C-positions 5, 7 and 4', a double bond between carbons 2 and 3, as well as a ketone group at position 4, exhibited potent inhibitory actions on the venom hyaluronidases.
Kuppusamy
U R
UR
Department of Biochemistry, Faculty of Medicine, National University of Singapore.
Das
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NP
D001514:Bee Venoms / Q000201:enzymology*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D012910:Snake Venoms / Q000201:enzymology*; D013329:Structure-Activity Relationship
D001514:Bee Venoms; D005419:Flavonoids; D012910:Snake Venoms; D006821:Hyaluronoglucosaminidase