[Methodology of regional blood stabilization with sodium citrate during hemosorption and the first experience of its clinical application].
The method of blood stabilization using sodium citrate ("Glugicir") has been elaborated. The experimental hemosorptions (HS) have shown that reliable blood stabilization in extracorporeal sorption contour was achieved with Glugicir/blood ratio 1 to 10, no considerable changes in the basic clearance characteristics of the sorbents have been observed. The method elaborated was used in 135 HS sessions performed in 100 patients. It has been shown that sodium citrate causes no changes in the patients' hemostasis. The method of regional blood stabilization with sodium citrate may be recommended for HS in patients with bleeding or high risk of its development. Mild symptoms of citrate intoxication (3.7%) were associated with technical inaccuracy and were easily eliminated either by discontinuation of excessive Glugicir introduction into the contour or by intravenous injection of calcium salts.
Egorov
V M
VM
Nazarov
A V
AV
Sentsov
V G
VG
Sukhanov
V A
VA
Ignatenko
T V
TV
Rokin
S R
SR
Amon
E P
EP
D001769:Blood / Q000187:drug effects*; D002951:Citrates / Q000494:pharmacology*; D019343:Citric Acid; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D011041:Poisoning / Q000628:therapy*
D002951:Citrates; D019343:Citric Acid
Metodika regionarnoĭ stabilizatsii krovi tsitratom natriia pri gemosorbtsii i pervyĭ opyt ee klinicheskogo primeneniia.