Molecular mediators and events associated with attenuated MHC class I gene expression.
Numerous examples of altered expression of MHC class I antigens by cells with a malignant phenotype have been described. Of particular interest in this regard has been the description of neoplastic cells with attenuated class I antigen expression. The model system used in this laboratory for understanding the molecular mediators and events associated with attenuation in MHC class I gene expression enlists the use of Abelson virus transformed leukemia cells from which H-2 surface null variants have been immunoselected. For these variants, interdiction in MHC antigen expression occurs at many levels of eukaryotic gene regulation. The regulated expression of H-2 antigens from these somatic cell variants is discussed in relationship to the mechanisms of attenuated MHC class I gene expression described for other leukemias.
Zeff
R A
RA
Department of Pathology, University of Connecticut Health Center, Farmington 06032.
D000011:Abelson murine leukemia virus; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D002461:Cell Line, Transformed; D005786:Gene Expression Regulation; D015973:Gene Expression Regulation, Leukemic; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis* / Q000235:genetics; D007942:Leukemia, Experimental / Q000235:genetics / Q000276:immunology; D051379:Mice; D011519:Proto-Oncogenes; D013724:Teratoma / Q000235:genetics / Q000276:immunology
D000951:Antigens, Neoplasm; D006183:H-2 Antigens; D015395:Histocompatibility Antigens Class I