RU486 combined with PG analogs in voluntary termination of pregnancy.
This French study evaluates the clinical results of administering RU486 with prostaglandin analogs in early pregnancy. Since 1986, RU486 has been used with prostaglandin analogs to interrupt pregnancies of less than 49 days' amenorrhea. Success rate among 10,250 cases was 95.3%. Failures involve ending of pregnancy without expulsion (2.8%), and ongoing pregnancy (1.1%). Two cases of cardiovascular complications following administration of the prostaglandin have occurred. The majority of users prefer this method because it eliminates need for surgery and anesthesia, and it allows the patient to take an active role in the procedure.
Aubeny
E
E
Family Planning Center, Broussais Hospital, Paris, France.
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000009:adverse effects; D000028:Abortion, Induced / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011465:Prostaglandins, Synthetic / Q000008:administration & dosage* / Q000009:adverse effects; D014592:Uterine Hemorrhage / Q000209:etiology
D000020:Abortifacient Agents, Nonsteroidal; D011465:Prostaglandins, Synthetic; D015735:Mifepristone