[Free amino acids in rat blood serum during A-hypovitaminosis].
A pool of free aminoacids of the blood serum has been studied in growing rats with a decreased retinol content in the liver tissue (to 5 g/g). The study shows a reliable drop in the concentrations of all essential aminoacids, except for phenylalanine. It is determined that the total amount of essential aminoacids decreases by 31%. At the same time concentrations of replaceable aminoacids increase, namely: glutamic acid and arginine--by 15.7%, ornithine and histidine--by 24%-45%, though proline concentration decreases abruptly by 31%. A disturbance in ultrastructural organization of microvilli in the apical membrane cells absorptive epithelium of the small intestine has been found. The results of the study confirm changes in a free aminoacid pool of the blood serum in growing rats and these changes occur first of all due to the disturbance of the absorption processes in the small intestine.
Prokopenko
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Gulich
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MP
D000596:Amino Acids / Q000097:blood*; D000601:Amino Acids, Essential / Q000097:blood; D000818:Animals; D007421:Intestine, Small / Q000648:ultrastructure; D008871:Microvilli / Q000648:ultrastructure; D051381:Rats; D014802:Vitamin A Deficiency / Q000097:blood*
D000596:Amino Acids; D000601:Amino Acids, Essential
Svobodnye aminokisloty syvorotki krovi krys pri A-gipovitaminoze.