The effect of acetylsalicylic acid on the development of the skeletal system in rats.
The authors wished to clarify the cause of micro- and phocomelia developing in rat fetuses following administration of acetylsalicylic acid. It has been proved by histological examinations that the positive ground substance of the epiphyseal cartilage, detected by Rivanol reaction, became disarranged or negative. The sulphation of glycosaminoglycans was diminished or inhibited by acetylsalicylic acid in the chondrocytes depending on the dose applied. The conclusion has been drawn that the malformation developed is due to the reduced production of sulphated mucopolysaccharides.
Tátrai
E
E
National Institute of Occupational Health, Budapest, Hungary.
Ungváry
G
G
D000818:Animals; D001241:Aspirin / Q000009:adverse effects*; D002356:Cartilage / Q000187:drug effects*; D005269:Femur / Q000187:drug effects / Q000196:embryology*; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D001241:Aspirin