title: Electron microscopic appearance of the chronic Campylobacter jejuni enteritis of mice.
abstract: Campylobacter jejuni is a major cause of human enteritis which mimics the inflammatory bowel disease (IBD). In this study, microstructural changes on the surfaces of the murine gastrointestinal tract persistently colonized by Campylobacter jejuni, strain GJ-S131, were investigated by using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results revealed that the appearance of the gastrointestinal mucosa in both BALB/C and KM mice resembled that in human with inflammatory bowel disease. Under SEM, the mucosa of the jejunum and ileum, with broken or distorted villi had a "worm eaten" look; crypts were irregular in shape and size, and the mucosa showed atrophy, especially in the colon. Epithelial junctions demonstrated furrows, clefts or deep crevasses, with exudates containing a large number of leukocytes. Cytologic appearances were characterized by microvilli dysplasia and/or atrophy, patchy erosions or necrosis and pelade-like appearance due to absence of microvilli, which were similar to the findings under TEM.
authors.affiliation: Shanghai Institute of Immunology, Shanghai Second Medical University.
authors.forename: J X
authors.initials: JX
authors.lastname: Gao
authors.forename: B L
authors.initials: BL
authors.lastname: Ma
authors.forename: Y L
authors.initials: YL
authors.lastname: Xie
authors.forename: D S
authors.initials: DS
authors.lastname: Huang
mesh_terms: D000818:Animals; D002169:Campylobacter Infections; D016123:Campylobacter jejuni; D002908:Chronic Disease; D004751:Enteritis / Q000382:microbiology / Q000473:pathology*; D005260:Female; D007583:Jejunum / Q000648:ultrastructure*; D051379:Mice; D008807:Mice, Inbred BALB C; D008855:Microscopy, Electron, Scanning