Studies on the antifertility components from Marsdenia koi.
By random screening test, Marsdenia koi was found to have antifertility activity on SD rat. From MeOH extracts of this plant two steroidal glycosides, marsdekoiside A and B, were isolated, and their structures were elucidated on the basis of spectral evidence and by comparison of the hydrolysis products with the authentic samples. Both are newly identified compounds, and marsdekoiside A has good antifertility activity.
Yuan
J L
JL
Family Planning Research Institute, Tongji Medical University, Wuhan.
Ding
W P
WP
Shi
J P
JP
Lu
Z Z
ZZ
Zhou
B N
BN
Erdelmeier
C A
CA
Cordell
G A
GA
Fong
H H
HH
Farnsworth
N R
NR
D000818:Animals; D003271:Contraceptive Agents, Female / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005260:Female; D011278:Pregnanes; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D003271:Contraceptive Agents, Female; D004365:Drugs, Chinese Herbal; D011278:Pregnanes; D012503:Saponins; C072846:marsdekoiside B; C072845:marsdekoiside A