title: Regulation of noradrenergic coerulean neuronal firing mediated by 5-HT2 receptors: involvement of the prepositus hypoglossal nucleus.
abstract: Previous studies have indicated a 5-HT2-mediated inhibitory influence on unit activity in the locus coeruleus. In the present work, attempts were made to determine which area(s) of the brain is (are) involved in this effect: (1) Microiontophoretic application of serotoninergic compounds (quipazine, ketanserin, RU 24969 (Roussel Uclaf), 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), metergoline, serotonin) in the locus coeruleus, did not alter the coerulean discharge. Local microinjection of quipazine or ketanserin in the area of the locus coeruleus, as well as in one of its major afferents, the prepositus hypoglossi, had no effect on the unit activity in the locus coeruleus. (2) Section of the forebrain, caudal to the frontal cortex (rich in 5-HT2 receptors), did not modify the effects of coerulean activity of quipazine-ketanserin injected systemically: quipazine induced an inhibition which was reversed by ketanserin. In contrast, these effects were significantly reduced after the bilateral or contralateral lesion of the prepositus hypoglossi. It is concluded that the prepositus hypoglossal nucleus is part of the network responsible for the 5-HT2-mediated control of unit activity in the locus coeruleus.
authors.affiliation: INSERM U.288, Neurobiologie Cellulaire et Fonctionnelle, CHU Pitié-Salpêtrière, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Gorea
authors.forename: D
authors.initials: D
authors.lastname: Davenne
authors.forename: L
authors.initials: L
authors.lastname: Lanfumey
authors.forename: M
authors.initials: M
authors.lastname: Chastanet
authors.forename: J
authors.initials: J
authors.lastname: Adrien
mesh_terms: D000818:Animals; D007002:Hypoglossal Nerve / Q000166:cytology / Q000187:drug effects*; D007478:Iontophoresis; D008024:Ligands; D008125:Locus Coeruleus / Q000166:cytology / Q000502:physiology*; D008297:Male; D008845:Microinjections; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D011903:Raphe Nuclei / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000502:physiology
chemical_list: D008024:Ligands; D011985:Receptors, Serotonin; D012701:Serotonin; D009638:Norepinephrine