title: Oligotyping of celiac multiplex families with the 11th International Histocompatibility Workshop reagents.
abstract: Using PCR and SSO probes from the 11th International Histocompatibility Workshop, we oligotyped for HLA-DRB1 gene and DQA1*0501, DQB1*0201 alleles 10 celiac families each with 2 affected children. All families belong to the Italian population except for one, whose mother is originally from Cape Verde island. 8/10 sibling pairs share the DQA1*0501/B1*0201 heterodimer, inherited in cis or in trans arrangement. All the dimer-negative patients were DR4-positive.
authors.affiliation: Department of Experimental Medicine, University La Sapienza, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Petronzelli
authors.forename: P
authors.initials: P
authors.lastname: Ferrante
authors.forename: P
authors.initials: P
authors.lastname: Triglione
authors.forename: M
authors.initials: M
authors.lastname: Bonamico
authors.forename: M C
authors.initials: MC
authors.lastname: Mazzilli
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000235:genetics* / Q000276:immunology; D002648:Child; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007558:Italy; D008297:Male; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction
chemical_list: D006684:HLA-DR Antigens; D015345:Oligonucleotide Probes