Clinical significance of squamous cell carcinoma antigen in cancer of the human uterine cervix. Comparison with CEA and CA-125.
Serum squamous cell carcinoma antigen (SCCa) concentrations were determined by a radioimmunoassay kit before and during the treatment of 50 patients with cervical carcinoma: 44 with squamous cell carcinoma (SCC) and 6 with adenocarcinoma. The positivity rate of SCCa was 50% (52% for SCC and 33% for adenocarcinoma). The sensitivity of SCCa for SCC was twice as high as that of CEA and CA-125. Low serum concentrations were observed in early-stage carcinoma, indicating that SCCa is not useful for diagnosis. In advanced cases, serum levels were directly and significantly correlated with the stage of the disease.
Verlooy
H
H
Department of Nuclear Medicine, University Hospital Gasthuisberg, Leuven, Belgium.
Devos
P
P
Janssens
J
J
Mortelmans
L
L
Gerits
M
M
Bonte
J
J
De Roo
M
M
D000230:Adenocarcinoma / Q000097:blood / Q000453:epidemiology / Q000473:pathology; D000951:Antigens, Neoplasm / Q000097:blood*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000453:epidemiology / Q000473:pathology; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D011863:Radioimmunoassay; D012680:Sensitivity and Specificity; D015843:Serpins; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000473:pathology
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D015843:Serpins; C051072:squamous cell carcinoma-related antigen