Is there a link between debrisoquine oxidation phenotype and lung cancer susceptibility?
A link between debrisoquine oxidation phenotype and lung cancer susceptibility has been evoked by some authors but not confirmed by others. For this reason, we compared the frequency of debrisoquine poor metabolizer phenotype in 91 Belgian patients with lung cancer to that studied in 167 healthy Belgian subjects. No significant difference was observed in our study. These results do not support the existence of this link.
Horsmans
Y
Y
Laboratoire de pharmacothérapie, Université catholique de Louvain, Brussels, Belgium.
Desager
J P
JP
Harvengt
C
C
D000328:Adult; D000368:Aged; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010641:Phenotype
D003647:Debrisoquin