title: [Pharmacokinetic studies of flomoxef in the neonatal field].
abstract: Flomoxef (FMOX), a new broad spectrum oxacephem antibiotic, was studied in the neonatal field and the pharmacokinetic results obtained are summarized below. 1. Serum concentrations of FMOX after dosages of 20 mg/kg via 1 hour drip infusion were 21.8 +/- 7.59 micrograms/ml, 15.4 +/- 4.35 micrograms/ml, 4.3 +/- 2.88 micrograms/ml at 1, 2 and 5 hours after administration, respectively, and T 2/1 (beta)'s averaged 2.08 +/- 1.01 hours. 2. Urinary excretion rates were 53.38 +/- 16.94% in the first 7 hours after administration.
authors.affiliation: Department of Pediatric Surgery, Juntendo University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Miyano
authors.forename: H
authors.initials: H
authors.lastname: Shimomura
mesh_terms: D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D013997:Time Factors
chemical_list: D002511:Cephalosporins; C045693:flomoxef