title: Effects of testosterone on the liver of castrated rats: morphologic study.
abstract: It is well known that castration in rats causes atrophy of the sexual organs and, to a lesser extent, of other organs. We have observed that castration causes a reduction of the liver weight due to a reduction (-10%) of the numerical density of the hepatocytes after castration (p less than 0.01). Testosterone administration at high concentration (2.5 mg/100 g b. wt.) as well as at low concentration (0.025 mg/100 g) in the castrated rats causes an increase of the liver weight due to an increase (+30%) in the cellular area (p less than 0.001) as well as in the nuclear area (+20%) (p less than 0.01) of the hepatocytes, revealing a powerful hypertrophic effect of the hormone in the liver.
authors.affiliation: University of Siena, Institute of Pathological Anatomy, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Tanganelli
authors.forename: G
authors.initials: G
authors.lastname: Bianciardi
authors.forename: L
authors.initials: L
authors.lastname: Barbagli
authors.forename: A
authors.initials: A
authors.lastname: Paffetti
authors.forename: A
authors.initials: A
authors.lastname: Di Stefano
authors.forename: M
authors.initials: M
authors.lastname: Pizzichini
authors.forename: E
authors.initials: E
authors.lastname: Marinello
mesh_terms: D000818:Animals; D002452:Cell Count; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008297:Male; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology*; D015430:Weight Gain / Q000187:drug effects; D015431:Weight Loss
chemical_list: D013739:Testosterone