Polymorphisms of serum proteins in Japanese patients with vascular diseases. I. Factor XIIIB, plasminogen and complement types in primary varicose veins.
The polymorphisms of the B subunit of coagulation factor XIII (F13B), plasminogen (PLG), complement C6, C7, factor B (BF) and factor I (IF) were studied among 21 unrelated Japanese patients with primary varicose veins (PVV) by isoelectric focusing followed by immunoblotting. The allele frequencies for F13B*2 and IF*A in PVV patients were significantly higher (F13B*2, p = 0.0047; IF*A, p = 0.0006) than those in healthy controls (n = 60). Significant associations of F13B 2 allotype [p = 0.0220, relative risk (RR) = 13.9] and IF A allotype (p = 0.0006, RR = 10.0) with PVV were observed; however, no significant association of PLG, C6, C7 or BF allotype with the disease was found.
Mizutani
K
K
First Department of Surgery, School of Medicine, Ehime University, Japan.
Nishimukai
H
H
Yasugi
T
T
Iwahashi
K
K
Tsunekawa
K
K
Shinomiya
T
T
D000328:Adult; D000483:Alleles; D001798:Blood Proteins / Q000235:genetics*; D003165:Complement System Proteins / Q000235:genetics*; D005176:Factor XIII / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010958:Plasminogen / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D014648:Varicose Veins / Q000097:blood / Q000235:genetics*
D001798:Blood Proteins; D010958:Plasminogen; D003165:Complement System Proteins; D005176:Factor XIII; C054380:factor XIIIb