Gastroprotective effect of nitrendipine on stress-induced gastric lesions in rats.
The effects of nitrendipine on stress-induced acute gastric lesions were investigated in rats. Intraperitoneally injected nitrendipine (8, 16, or 32 mg/kg) given 30 min before stress, dose-dependently prevented gastric glandular ulceration. The anti-ulcer effects of nitrendipine were not reversible by indometacin or dexamethasone. These results suggest that calcium is important in gastric pathophysiology and that the proof of gastroprotective effects of calcium channel blockers is of great value in the development of new and improved therapies for treatment and prevention of gastric ulcers in humans.
Ulak
G
G
Department of Pharmacology, Medical Faculty, Dicle University, Diyarbakir, Turkey.
Cingi
M I
MI
Erol
K
K
D000818:Animals; D003080:Cold Temperature; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D007103:Immobilization; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009568:Nitrendipine / Q000627:therapeutic use*; D010438:Peptic Ulcer Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D013276:Stomach Ulcer / Q000150:complications / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D003907:Dexamethasone; D009568:Nitrendipine; D007213:Indomethacin