Metabolism of benzothiazole. I. Identification of ring-cleavage products.
1. The metabolic fate of benzothiazole in guinea pig has been investigated following i.p. administration at a dose of 30 mg/kg. 2. Five ring-cleavage products were identified in urinary extracts by g.l.c.-mass spectra. By reference to authentic compounds the three major metabolites were shown to be 2-methylmercaptoaniline (I), 2-methylsulphinylaniline (II) and 2-methylsulphonylaniline (III). On the basis of the mass spectrometric evidence the remaining two metabolites were postulated to be 2-methylsulphinylphenylhydroxylamine (IV) and 2-methylsulphonylphenylhydroxylamine (V). 3. I, II and III were present in conjugated and unconjugated forms; IV and V were identified only after hydrolysis with sulphatase.
Wilson
K
K
School of Natural Sciences, Hatfield Polytechnic, Hertfordshire, UK.
Chissick
H
H
Fowler
A M
AM
Frearson
F J
FJ
Gittins
M
M
Swinbourne
F J
FJ
D000818:Animals; D052160:Benzothiazoles; D002849:Chromatography, Gas; D006168:Guinea Pigs; D006868:Hydrolysis; D066298:In Vitro Techniques; D008297:Male; D013058:Mass Spectrometry; D013429:Sulfatases / Q000378:metabolism; D013844:Thiazoles / Q000378:metabolism*
D052160:Benzothiazoles; D013844:Thiazoles; D013429:Sulfatases; C005465:benzothiazole