title: Measurements of the effect of dipyridamole on regional myocardial blood flow with positron emission tomography and the first-pass flow model.
abstract: We assessed percent changes of regional myocardial blood flow (RMBF) after infusion of dipyridamole (0.56 mg/kg) with dynamic N-13 ammonia PET and the first-pass flow model. Positron emission tomography (PET) was performed at rest and after infusion of dipyridamole in 17 participants [five normal subjects, five patients with hypertrophic cardiomyopathy (HCM), and seven patients with coronary artery disease]. Dipyridamole increased RMBF 126 +/- 69% (mean +/- SD) in normal subjects and 55 +/- 43% in the patients with HCM. In the cases of coronary artery disease, the percent changes of RMBF were +19 +/- 19% in ischemic areas and +76 +/- 23% in nonischemic areas. These results demonstrate that N-13 ammonia dynamic PET study is useful in assessing the percent changes of RMBF induced by dipyridamole infusion.
authors.affiliation: Third Department of Internal Medicine, Chiba University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Himi
authors.forename: M
authors.initials: M
authors.lastname: Endo
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: A
authors.initials: A
authors.lastname: Kagaya
authors.forename: Y
authors.initials: Y
authors.lastname: Masuda
authors.forename: Y
authors.initials: Y
authors.lastname: Inagaki
authors.forename: H
authors.initials: H
authors.lastname: Fukuda
authors.forename: T
authors.initials: T
authors.lastname: Iinuma
authors.forename: T
authors.initials: T
authors.lastname: Yamasaki
authors.forename: N
authors.initials: N
authors.lastname: Fukuda
mesh_terms: D000328:Adult; D000368:Aged; D000641:Ammonia; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000503:physiopathology; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D004176:Dipyridamole / Q000494:pharmacology; D006801:Humans; D008875:Middle Aged; D008955:Models, Cardiovascular; D009590:Nitrogen Radioisotopes; D015203:Reproducibility of Results; D012146:Rest; D014055:Tomography, Emission-Computed; D015646:Ventriculography, First-Pass
chemical_list: D009590:Nitrogen Radioisotopes; D004176:Dipyridamole; D000641:Ammonia