Inhibition of mouse skin tumor promotion by tenuazonic acid.
Tenuazonic acid (TA) was topically applied to the interscapular region of Swiss albino mice at different doses before the application of 12-O-tetradecanoyl phorbol-13-acetate (TPA). Skin from the painted area was examined for ornithine decarboxylase (ODC) enzyme estimation. It was observed that TA inhibited TPA induced ODC activity. The inhibitory effect of TA was also found in mouse skin tumor promotion in the two stage initiation promotion protocol. There was a remarkable delay in the latency period and decrease in the number of tumors developed and the percentage of tumor bearing animals after TA treatment.
Antony
M
M
Laboratory of Environmental Carcinogenesis, Industrial Toxicology Research Centre, Lucknow, India.
Gupta
K P
KP
Janardanan
K K
KK
Mehrotra
N K
NK
D000287:Administration, Topical; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009955:Ornithine Decarboxylase / Q000096:biosynthesis / Q000187:drug effects; D065108:Ornithine Decarboxylase Inhibitors; D012867:Skin / Q000187:drug effects / Q000201:enzymology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013720:Tenuazonic Acid / Q000627:therapeutic use*; D013755:Tetradecanoylphorbol Acetate
D065108:Ornithine Decarboxylase Inhibitors; D013720:Tenuazonic Acid; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate