[Effects of dalargin on the proliferative processes of the gastric epithelium under repeated action of different stressors].
Using radiography with H-thymidine method we studied the synthesis of DNA process in pyloric parts of stomach epithelium in white rats, which have been five-fold effected by different kinds of stressors against a background of dalargin injections. In the first hour after animals were stressed, DNA synthesis was depressed. Dalargin injections caused DNA synthesis normalization in the first hour after hypoxia and hyperthermia. Since 24 hours after hyperthermia and immobilization against a background of dalargin injections the normalization of DNA synthesis took place, and after hypoxia the post-stressing IMN activation was growing week. One of the mechanisms of dalargin correction of DNA synthesis breach under the influence of stressors is a stabilization of noradrenaline and histamine concentration in tissue of the stomach.
Timoshin
S S
SS
Shvets
S I
SI
Radivoz
M I
MI
Aleksandrovich
A G
AG
Mel'nik
E I
EI
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004847:Epithelial Cells; D004848:Epithelium / Q000737:chemistry / Q000187:drug effects; D005334:Fever / Q000503:physiopathology; D006632:Histamine / Q000032:analysis; D000860:Hypoxia / Q000503:physiopathology; D007103:Immobilization; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D013270:Stomach / Q000737:chemistry / Q000166:cytology / Q000187:drug effects*; D013312:Stress, Physiological / Q000503:physiopathology*
D016308:Enkephalin, Leucine-2-Alanine; D006632:Histamine; D004247:DNA; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D009638:Norepinephrine
Vliianie dalargina na proliferativnye protsessy épiteliia zheludka pri povtornykh vozdeĭstviiakh razlichnykh strssorov.