title: Gastrointestinal protein loss in children recovering from burns.
abstract: Qualitative gastrointestinal protein loss was evaluated in 10 children with second- and/or third-degree burns covering 10% or more of their body surface area (BSA) by using fecal alpha-1-antitrypsin (FA-1-AT) as a marker. Patients were subdivided according to the extent of the burned area: group I (5 patients) had burns covering less than 20% of BSA; group II (5 patients) had burns covering more than 20% of BSA (mean, 37.2% = 24.9%). Results were compared with those of 12 healthy normal controls. Mean maximal FA-1-AT excretion in group II patients (2.71 +/- 1.35 mg/g) was significantly greater than that found in group I children (0.43 +/- 0.26 mg/g; P = .006) and in the controls (0.62 +/- 0.25 mg/g; P = .004). The mean maximal FA-1-AT excretion positively correlated to the percent of BSA covered with burns (r = 0.83). Although the mean septic score (SS) of group I patients (7 +/- 2.9) was significantly greater than that calculated for group II children (3 +/- 2.45; P = .047), only 2 patients in group II had positive microbiological cultures. Patients in both groups had received more than the recommended enteral caloric and protein allowance during the 96 hours prior to the maximal FA-1-AT measurements. Within this range, no correlation was found between the amount of FA-1-AT and the number of calories per kilogram protein consumed. By using the method of FA-1-AT quantification, this study provides the first report on postburn intestinal protein loss in children.
authors.affiliation: Department of Pediatrics, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Matoth
authors.forename: E
authors.initials: E
authors.lastname: Granot
authors.forename: A
authors.initials: A
authors.lastname: Gorenstein
authors.forename: K
authors.initials: K
authors.lastname: Abu-Dalu
authors.forename: K
authors.initials: K
authors.lastname: Goitein
mesh_terms: D002056:Burns / Q000150:complications* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000502:physiology / Q000503:physiopathology*; D008297:Male; D011504:Protein-Losing Enteropathies / Q000209:etiology* / Q000503:physiopathology; D011506:Proteins / Q000502:physiology*; D012709:Serum Albumin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis*
chemical_list: D011506:Proteins; D012709:Serum Albumin; D000515:alpha 1-Antitrypsin