Naloxone-induced hypoalgesia: effects of noradrenergic antagonists and agonist.
The present experiments confirmed that rats injected with naloxone and exposed to a heated floor acquired a hypoalgesic response, as indexed by the latencies to lick their paws. The expression of these latencies were unaffected by yohimbine, clonidine, propranolol, or by relatively moderate doses of prazosin, suggesting that the conditioned hypoalgesic response induced by pairings of naloxone and a heated floor is not mediated by the release and turnover of noradrenaline.
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School of Psychology, University of New South Wales, Kensington, Sydney, Australia.
Westbrook
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D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D006358:Hot Temperature; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology
D015016:Yohimbine; D009270:Naloxone; D011433:Propranolol; D003000:Clonidine; D009638:Norepinephrine; D011224:Prazosin