Effects of hypoxia on a potassium channel in cat cerebral arterial muscle cells.
We have shown that exposure of isolated cat cerebral arterial muscle cells to hypoxic environments increases K+ channel activity when recorded in the cell-attached mode. Inhibition by glibenclamide of the "hypoxia-induced" increase in K+ channel activity may suggest that increased activity is mediated by an ATP sensitive K+ channel. Thus, the level of O2 may modulate cerebral vascular tone by an action on membrane K+ channels, possibly mediated by the concentration of intracellular ATP.
Bonnet
P
P
Laboratoire d'Electrophysiologie et de Pharmacologie Cellulaires, Parc de Grandmont Fac. des Sciences Tours, France.
Gebremedhin
D
D
Rush
N J
NJ
Harder
D R
DR
D000818:Animals; D001488:Basilar Artery / Q000502:physiology; D002415:Cats; D015687:Cell Hypoxia / Q000502:physiology*; D002478:Cells, Cultured; D008564:Membrane Potentials / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*
D015221:Potassium Channels