[Sensitivity of Pseudomonas mallei to fluoroquinolones and their efficacy in experimental glanders].
Thirteen strains of P. mallei were found to be highly sensitive to ciprofloxacin and ofloxacin and resistant to norfloxacin. Ciprofloxacin and ofloxacin showed a high efficacy on models of malleus in guinea pigs and hamsters. The animals were infected with various strains of P. mallei. In the in vitro experiments, ciprofloxacin proved to be the most active and efficient. Norfloxacin appeared to be inefficient.
Batmanov
V P
VP
D000818:Animals; D002939:Ciprofloxacin / Q000627:therapeutic use*; D006224:Cricetinae; D004352:Drug Resistance, Microbial / Q000502:physiology; D005896:Glanders / Q000188:drug therapy*; D006168:Guinea Pigs; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000627:therapeutic use*; D015242:Ofloxacin / Q000627:therapeutic use*; D011549:Pseudomonas / Q000187:drug effects*
D002939:Ciprofloxacin; D015242:Ofloxacin; D009643:Norfloxacin
Chuvstvitel'nost' Pseudomonas mallei k ftorkhinolonam i éffektivnost' ikh pri éksperimental'nom sape.