[The effect of antibiotics on the function of type-II and -III glucocorticoid receptors].
The effects of antibiotics on functioning glucocorticoid receptors of types II and III of male Wistar rat liver cytosol were studied. All the studied antibiotics at the concentration of 10(-3) M increased 1.6-2.4 times the function of glucocorticoid receptors of type III. At the concentration of 10(-4) M, except cephazolin and kanamycin, all antibiotics also enhanced the function of glucocorticoid receptors of types III, although to a lesser degree than at the concentration of 10(-3) M. The influence of antibiotics on the function of glucocorticoid receptors of type II is diverse. If antibiotics of penicillin and cephalosporin group increased, antibiotics of streptomycin, rifamycin, aminoglycosides and levomicetine group, on the contrary, decreased the function of type II glucocorticoid receptors. The practical importance of the agents regulating the function of glucocorticoid receptors is discussed.
Golikov
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PP
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003345:Corticosterone / Q000378:metabolism*; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000145:classification / Q000187:drug effects* / Q000378:metabolism; D014222:Triamcinolone Acetonide / Q000378:metabolism*; D014316:Tritium
D000900:Anti-Bacterial Agents; D011965:Receptors, Glucocorticoid; D014316:Tritium; D014222:Triamcinolone Acetonide; D003345:Corticosterone
Vliianie antibiotikov na funktsiiu gliukokortikoidnykh retseptorov II i III tipov.