title: Computer simulation of surface-induced aggregation of ferritin.
abstract: Models are presented describing the transient mass-transport limited adsorption and cluster growth of ferritin at a solid surface. Computer simulations are carried out on a hexagonal lattice using a computer model that can be characterized as a two-dimensional stochastic cellular automaton allowing different rules regarding association, lateral interaction and dissociation to be incorporated in the model. The fractal dimensions of individual clusters were extracted from simulated aggregates and for similar rules found to be consistent with literature values on reversible diffusion-limited aggregation in two dimensions. The distribution of clusters versus free surface were shown to be affected by neighbor-dependent association probability. Low fractal dimension clusters were generated by a combination of strong lateral cohesion and neighbor-dependent dissociation to the bulk. By comparing computer simulated aggregation to experimental electron micrographs of adsorbed ferritin layers it is suggested that neighbor-dependent association, neighbor-dependent dissociation and lateral interactions are important factors in the complex dynamics of adsorbed protein layers.
authors.affiliation: Department of Histology, University of Göteborg, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Stenberg
authors.forename: H
authors.initials: H
authors.lastname: Nygren
mesh_terms: D003198:Computer Simulation; D005293:Ferritins / Q000737:chemistry* / Q000648:ultrastructure; D008854:Microscopy, Electron
chemical_list: D005293:Ferritins