Genetic transmission of migraine without aura: a study of 68 families.
68 randomly selected patients with migraine without aura (M) and 4 generations of their relatives (N = 394) were studied in order to probe the genetic hypothesis of migraine. Significantly more of the probands were women and M was significantly more frequent among female relatives. Earlier onset was commoner among male probands. A genetic component of M is indicated by the very high frequency of at least one affected relative (85.3%) and by a disease prevalence that is similar among both first and second degree relatives. A simple autosomal mode of transmission seems unlikely from analysis of the data on the affected relatives, while a "sex-limited" transmission mode is suggested.
D'Amico
D
D
Centro Cefalee, Istituto Nazionale Neurologico, C. Besta, Milano.
Leone
M
M
Macciardi
F
F
Valentini
S
S
Bussone
G
G
D000328:Adult; D000367:Age Factors; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000235:genetics*; D012737:Sex Factors