Brain tumours and the occurrence of severe invasive basal cell carcinoma in first degree relatives with Gorlin syndrome.
We describe the occurrence of a medulloblastoma and an astrocytoma in successive generations of a family with the Gorlin syndrome. The appearance of thousands of invasive basal cell carcinomata after craniospinal irradiation led to the death of one patient from intracranial involvement.
Evans
D G
DG
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK.
Birch
J M
JM
Orton
C I
CI
D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000473:pathology; D001478:Basal Cell Nevus Syndrome / Q000235:genetics* / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002280:Basal Cell Carcinoma / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000473:pathology / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology