title: Rationale for the design of biomaterials and the evaluation of their biocompatibility.
abstract: The biocompatibility of a material can be considered as the ideally expectable result of its interactions with living tissues with which it is interfaced. This property determines the ability of devices involving this material in their constitution, to correctly assume their ascribed function; reciprocally a bad fitting, between devices and their intended use, coming from a non-optimized design or from an inappropriate prescription, may alter the original biocompatibility of constitutive materials. Accordingly, the actual biocompatibility of a biomaterial depends upon both its intrinsic properties and the application in which it is involved. Such considerations must be taken into account by specialists who try to design more performant biomaterials, or new assist devices, should they be implantable or not; but they draw also methodological guidelines for the evaluation of the biocompatibility of these biomedical products.
authors.affiliation: Inserm U.306, Université de Bordeux II, France.
authors.forename: C
authors.initials: C
authors.lastname: Baquey
authors.forename: B
authors.initials: B
authors.lastname: Dupuy
authors.forename: G
authors.initials: G
authors.lastname: Janvier
authors.forename: L
authors.initials: L
authors.lastname: Bordenave
authors.forename: J
authors.initials: J
authors.lastname: Caix
authors.forename: B
authors.initials: B
authors.lastname: Basse-Cathalinat
mesh_terms: D001672:Biocompatible Materials; D002319:Cardiovascular System; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D010179:Pancreas
chemical_list: D001672:Biocompatible Materials