title: Matrix remodelling and fibroblast phenotype in early lesions of human cutaneous leishmaniasis.
abstract: The connective matrix participates directly in early pathological events observed in the cutaneous lesion of leishmaniasis, due to Leishmania braziliensis guyanensis. A sample of 19 skin biopsies was examined by light and electron microscopy, in order to identify the matrix components (collagen isotypes I to IV, elastin and membrane associated proteins) of the dermal infiltrate, and the pattern of organization of the reparative connective matrix. An extensive remodelling process of apparently parasite-independent nature involves different fibroblast sub-populations. The original organization of this immune-mediated lesion offers a rare opportunity to study in situ the local inflammatory mediators inducing the activation of fibroblasts and macrophages.
authors.affiliation: Parasitology Laboratory, Institut Pasteur de Guyane française, Cayenne, French Guiana.
authors.forename: P
authors.initials: P
authors.lastname: Esterre
authors.forename: J P
authors.initials: JP
authors.lastname: Dedet
authors.forename: S
authors.initials: S
authors.lastname: Guerret
authors.forename: M
authors.initials: M
authors.lastname: Chevallier
authors.forename: C
authors.initials: C
authors.lastname: Frenay
authors.forename: J A
authors.initials: JA
authors.lastname: Grimaud
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001706:Biopsy; D003094:Collagen / Q000032:analysis; D003238:Connective Tissue / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D004549:Elastin / Q000032:analysis; D005109:Extracellular Matrix / Q000737:chemistry / Q000648:ultrastructure*; D005347:Fibroblasts / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006099:Granuloma / Q000473:pathology; D006790:Host-Parasite Interactions / Q000502:physiology; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000032:analysis; D008854:Microscopy, Electron; D010641:Phenotype
chemical_list: D008565:Membrane Proteins; D003094:Collagen; D004549:Elastin