title: [Immunodepressants used in immune system pathology. I. Cyclosporin, cyclophosphane, azathioprine and mercaptopurine].
abstract: The data on immunodepressants most commonly used in the Soviet Union in the diseases caused by disorders in normal function of the immune system are presented. Such drugs as cyclosporine A, cyclophosphan, azatioprine, 6-mercaptopurine are considered. Emphasis is given to the mechanism of the primary pharmacological response of the drugs to the immunocompetent cells, the grounding of their clinical use, dosage and mechanisms of possible side effects.
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Napolov
authors.forename: K B
authors.initials: KB
authors.lastname: Borisov
mesh_terms: D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007154:Immune System Diseases / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015122:Mercaptopurine / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003520:Cyclophosphamide; D015122:Mercaptopurine; D001379:Azathioprine
vernacular_title: Immunodepressanty, primeniaemye pri patologii immunnoĭ sistemy. I. Tsiklosporin, tsiklofosfan, azatioprin, merkatopurin.