A human T cell leukemia virus type-I carrier with recurrent thrombocytopenia and various autoantibodies.
A 34-year-old woman infected with human T cell leukemia virus type-I(HTLV-I) with recurrent thrombocytopenia and various autoantibodies is described. The platelet counts fluctuated between 1.3 x 10(4)/microliters and 14.8 x 10(4)/microliters without any medical treatment, and thrombocytopenia improved with a decrease of platelet-associated IgG (PA-IgG). Autoantibodies such as rheumatoid factor, antinuclear factor, anti-Sm, anti-RNP and anti-SSA antibodies were also recognized. Marker analysis of peripheral mononuclear cells showed an increase in the proportion of CD 25+ cells, CD 3+ HLA-DR+ cells, CD4+ HLA-DR+ cells and CD8+ HLA-DR+ cells. The recurrent thrombocytopenia and development of various autoantibodies in this HTLV-I carrier are speculated to be due to the alteration of B cell functions by T cells infected with HTLV-I.
Takahashi
I
I
Department of Medicine, Kochi Municipal Central Hospital, Japan.
Sano
M
M
Okamoto
H
H
Shiromoto
M
M
Nakamura
T
T
Ueno
K
K
Nakada
H
H
Haruta
Y
Y
Seto
T
T
Yamashita
J
J
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D002353:Carrier State; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D015490:HTLV-I Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D012008:Recurrence; D013921:Thrombocytopenia / Q000209:etiology*
D001323:Autoantibodies; D006684:HLA-DR Antigens