Decreased cerebral metabolism in stroke-prone spontaneously hypertensive rats (SHRSP) with stroke and its possible improvement by Solcoseryl.
Local cerebral glucose utilization (LCGU) was decreased in SHRSP with stroke compared with normotensive Wistar rats. The decrement of LCGU was less in Solcoseryl-treated SHRSP with stroke than that in saline-treated SHRSP with stroke and these brain areas where LCGU was less damaged, in Solcoseryl-treated SHRSP were consistent with the important functioning sites of emotion, motor movement and memory. The result suggests that Solcoseryl may be useful for metabolic improvement of the brain damage after stroke.
Yamasaki
Y
Y
Immunological and Cardiovascular Research Lab., Taiho Pharmaceutical Co. Ltd., Saitama, Japan.
Yamamoto
Y
Y
Senga
Y
Y
Isogai
M
M
Shimizu
H
H
Yamori
Y
Y
D000183:Actihaemyl / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002561:Cerebrovascular Disorders / Q000378:metabolism / Q000517:prevention & control*; D004198:Disease Susceptibility; D005947:Glucose / Q000378:metabolism; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains
D000183:Actihaemyl; D005947:Glucose