title: Use of scintigraphy for the determination of mucociliary clearance rates in normal, sedated, diseased and exercised horses.
abstract: Mucociliary clearance rates from the trachea were determined in normal, sedated, diseased and exercised horses from scintigraphs obtained after an injection of technetium-99m sulphide colloid into the tracheal lumen. The group mean tracheal clearance rate of eight clinically normal horses during 42 trials was 2.06 +/- 0.38 cm/min. Significant between horse differences were found (p less than 0.05). When six and seven of these horses were given xylazine and detomidine hydrochloride, respectively, mean group tracheal clearance rates dropped significantly (p less than 0.05). The decreases from each normal horse's mean tracheal clearance rate ranged from 18 to 54%. There did not appear to be a difference between the tracheal clearance rates (TCRs) of the normal horses and those with chronic respiratory disease. Postexercise evaluations were not significantly different from the pre-exercise TCRs in three clinically normal horses and three horses with chronic obstructive pulmonary disease (p greater than 0.05). This minimally invasive scintigraphic technique for determining TCRs has proved to be useful and reliable.
authors.affiliation: Equine Research Centre, University of Guelph, Ontario.
authors.forename: R A
authors.initials: RA
authors.lastname: Willoughby
authors.forename: G L
authors.initials: GL
authors.lastname: Ecker
authors.forename: S L
authors.initials: SL
authors.lastname: McKee
authors.forename: L J
authors.initials: LJ
authors.lastname: Riddolls
mesh_terms: D000818:Animals; D005080:Exercise Test / Q000662:veterinary; D006734:Horse Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006736:Horses / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D008173:Lung Diseases, Obstructive / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary; D009079:Mucociliary Clearance / Q000187:drug effects; D005082:Physical Exertion / Q000502:physiology*; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D012984:Software; D014132:Trachea / Q000000981:diagnostic imaging*; D014991:Xylazine / Q000494:pharmacology
chemical_list: D006993:Hypnotics and Sedatives; D007093:Imidazoles; D014991:Xylazine; C041255:detomidine