title: [Ca(2+)-dependent regulation of T-lymphocytes in experimental tuberculosis].
abstract: Ca(2+)-exchange kinetics and the content of membrane and cytoplasm fractions of calmodulin in the splenic T-lymphocytes of guinea pigs with experimental tuberculosis were studied. A tuberculous process was accompanied by the changes in the Ca2+ exchange kinetics in the form of T-lymphocyte oversaturation with Ca2+ ions which in the end leads to an inhibition of the functional status of the immunity T system. PPD, a specific allergen, brought the capacity of T lymphocytes down in relation to the cellular Ca2+ exchange, presumably causing the normalization of the immune response.
authors.forename: S V
authors.initials: SV
authors.lastname: Demidov
authors.forename: A P
authors.initials: AP
authors.lastname: Kostromin
authors.forename: E F
authors.initials: EF
authors.lastname: Chernushenko
authors.forename: V V
authors.initials: VV
authors.lastname: Kuibeda
authors.forename: M I
authors.initials: MI
authors.lastname: Borovik
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000502:physiology; D006168:Guinea Pigs; D013601:T-Lymphocytes / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000378:metabolism*
chemical_list: D002118:Calcium
vernacular_title: Ca2+-zavisimaia reguliatsiia T-limfotsitov pri eksperimental'nom tuberculeze.