Effects of naloxone on seizure latencies of black (a/a) Mongolian gerbils (Meriones unguiculatus).
The effects of the opiate antagonist, naloxone, on seizure tendencies of the black or nonagouti line of Mongolian gerbils (Meriones unguiculatus) carrying the a/a coat color allele was investigated. The animals were tested under the following conditions: mock infection; 0.9% NaCl injection; and naloxone at doses of 1, 2, 5, and 10 mg/kg body weight. The results indicated that when naloxone was at doses of 2 mg/kg body weight and higher, there was an increase in the animals' seizure latencies relative to that manifested under the basal condition.
Wong
R
R
Department of Psychology, University of British Columbia, Vancouver, Canada.
Gray-Allan
P
P
D000818:Animals; D001921:Brain / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects; D005849:Gerbillinae / Q000235:genetics*; D009270:Naloxone / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects* / Q000235:genetics* / Q000502:physiology; D012640:Seizures / Q000235:genetics* / Q000503:physiopathology*; D001615:beta-Endorphin / Q000235:genetics / Q000502:physiology
D009270:Naloxone; D001615:beta-Endorphin