Micronization by means of supercritical fluids: possibility of application to pharmaceutical field.
The state of the art in drug micronization is briefly reviewed. The Authors propose and discuss the adoption of a new micronization technique based on supercritical fluids properties: high solvent power and selectivity, fast solute precipitation. A supercritical spray apparatus that has been designed to maximize micronization of pharmaceutical interest products is described. A preliminary scanning of supercritical solvents and cosolvents suitable to dissolve poorly soluble products is also proposed.
Donsì
G
G
Istituto di Ingegneria Chimico-Alimentare, Facoltà di Ingegneria, Università di Salerno.
Reverchon
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E
D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods*