title: The structure of 6-phosphogluconate dehydrogenase refined at 2.5 A resolution.
abstract: The three-dimensional structure of ovine 6-phosphogluconate dehydrogenase, refined at 2.5 A resolution with a residual for all data of 18.5%, is reported. This model, based on improved diffraction data and a corrected sequence, supersedes that reported earlier. Each subunit of the dimer has three domains: a beta-alpha-beta domain binds NADP; an all alpha domain provides much of the dimer interface; the C-terminal tail burrows into the second subunit.
authors.affiliation: Laboratory of Molecular Biophysics, Oxford University, England.
authors.forename: M J
authors.initials: MJ
authors.lastname: Adams
authors.forename: S
authors.initials: S
authors.lastname: Gover
authors.forename: R
authors.initials: R
authors.lastname: Leaback
authors.forename: C
authors.initials: C
authors.lastname: Phillips
authors.forename: D O
authors.initials: DO
authors.lastname: Somers
mesh_terms: D015394:Molecular Structure; D010734:Phosphogluconate Dehydrogenase / Q000737:chemistry*; D011487:Protein Conformation; D014961:X-Ray Diffraction
chemical_list: D010734:Phosphogluconate Dehydrogenase