title: Calcium pyrophosphate dihydrate deposition disease: morphological and microanalytical features.
abstract: The light microscopic and polarization appearances of calcium pyrophosphate dihydrate crystal deposits in tissues are reviewed. In routine sections haematoxylinophilic crystalline deposits with a feathery or brush-like pattern are typical of calcium pyrophosphate dihydrate. Short rhomboidal crystals showing positive birefringence are seen on polarization; X-ray microanalytical and infrared spectroscopic data support the specificity of these appearances. The appearances of the crystal deposits in decalcified specimens are also described. We include six cases of calcium pyrophosphate dihydrate deposition within periarticular bone; to the best of our knowledge this has not previously been described.
authors.affiliation: Department of Histopathology, Lewisham Hospital, London, UK.
authors.forename: C E
authors.initials: CE
authors.lastname: Keen
authors.forename: P R
authors.initials: PR
authors.lastname: Crocker
authors.forename: K
authors.initials: K
authors.lastname: Brady
authors.forename: N
authors.initials: N
authors.lastname: Hasan
authors.forename: D A
authors.initials: DA
authors.lastname: Levison
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001718:Birefringence; D001847:Bone Diseases / Q000378:metabolism* / Q000473:pathology; D001842:Bone and Bones / Q000737:chemistry / Q000473:pathology; D002131:Calcium Pyrophosphate / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D002805:Chondrocalcinosis / Q000378:metabolism* / Q000473:pathology; D003460:Crystallization; D004577:Electron Probe Microanalysis; D005260:Female; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008859:Microscopy, Polarization; D008875:Middle Aged; D013055:Spectrophotometry, Infrared
chemical_list: D002131:Calcium Pyrophosphate