title: Tracheal cilia response to exogenous niacin in drinking water of turkey poults infected with Bordetella avium.
abstract: Niacin was added daily to the drinking water of control and Bordetella avium-infected turkey poults at a dosage of 0, 70, and 280 mg/liter over a 2-week experimental period. Fourteen days postinoculation, tracheal sections were examined by histological and morphometrical analysis of cilia, as well as agar plate isolation for bacteria. Infected poults exhibited a 96-97% loss of cilia along the tracheal epithelial border, compared with only a 4-5% loss in controls. Infected poults receiving niacin in the drinking water exhibited only a 61.0% and 76.0% loss of cilia at doses of 70 mg/liter and 280 mg/liter, respectively. The results indicate that niacin treatment may influence the pathogenicity of B. avium infection.
authors.affiliation: North Carolina State University, Department of Poultry Science, Raleigh 27695-7635.
authors.forename: A G
authors.initials: AG
authors.lastname: Yersin
authors.forename: F W
authors.initials: FW
authors.lastname: Edens
authors.forename: D G
authors.initials: DG
authors.lastname: Simmons
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001884:Bordetella / Q000187:drug effects; D001885:Bordetella Infections / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D002923:Cilia / Q000187:drug effects / Q000473:pathology; D004326:Drinking; D005260:Female; D008297:Male; D009525:Niacin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000188:drug therapy* / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D014132:Trachea / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology; D014422:Turkeys
chemical_list: D009525:Niacin