[Dermatological manifestations of Sjögren's syndrome].
In primary Sjögren's syndrome, various cutaneous manifestations may become apparent: annular erythema or eruptions reminiscent of erythema multiforme, lichen planus or erythema nodosum (dermo-panniculitis), chilblain-like erythema, purpura, cheilitis, and xerosis, are some of them. In the clinical diagnosis, the following laboratory tests are of value: Schirmer test, rose bengal test, fluorescence staining techniques, gum test, sialography, sialoscintigraphy, lip biopsy. In some cases, dryness can be absent though the above-mentioned skin manifestations are observed. Mothers with Sjögren's syndrome can deliver babies with neonatal lupus erythematosus. Serological testing almost always reveals anti-Ro/SSA-autoantibody and the more specific anti-La/SSB in the sera of patients. The sensitivity of detection can be enhanced by using the immunoblotting technique and the two-dimensional immunoblotting method. In some cases, a new antibody against carbonic anhydrase has been detected.
Ueki
H
H
Dermatologische Klinik, Kawasaki Medical School.
Inagaki
Y
Y
Hamasaki
Y
Y
Ono
M
M
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000302:isolation & purification; D019411:Clinical Laboratory Techniques; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*
D001323:Autoantibodies
Dermatologische Manifestationen des Sjögren-Syndroms.