Relationship between plasminogen activators and stomach carcinoma stage.
The antigen levels of plasminogen activators (PAs), tissue-type PA (t-PA) and urokinase-type PA (u-PA), were measured in extracts from 30 gastric carcinomas and corresponding normal gastric mucosa. The t-PA level was significantly higher in normal mucosa than in cancer tissue, while the u-PA level was significantly higher in cancer tissue. The u-PA level increased with increasing tumor stage, and there was a significant difference between early and advanced cancer. The u-PA level also increased with the degree of nodal involvement, and it was higher in undifferentiated tumors than in well-differentiated ones. It was higher in cases with venous invasion, liver metastasis or peritoneal dissemination than in cases without these features.
Umehara
Y
Y
First Department of Surgery, Hamamatsu University School of Medicine, Japan.
Kimura
T
T
Yoshida
M
M
Oba
N
N
Harada
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000276:immunology / Q000473:pathology; D010959:Tissue Plasminogen Activator / Q000032:analysis* / Q000276:immunology; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis* / Q000276:immunology
D000951:Antigens, Neoplasm; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator