Sex comparison of heme pathway in rats bearing hepatic tumors.
The present study was undertaken to explore the effect of the presence of hepatic tumors induced by diethylinitrosamine (DENA) on the metabolic heme pathway, and to assess whether these tumors can modify the response of rats to the porphyrinogenic drug hexachlorobenzene (HCB) and whether the above mentioned effects occur to a greater extent in females than males. The results obtained showed that: a) Females were more susceptible to the hepatocarcinogenicity of DENA than males. b) Female normal and DENA treated rats were more susceptible than male rats to the porphyrinogenicity of HCB. c) The presence of hepatic DENA induced tumors could diminish basal hepatic ferrochelatase activity. d) Hepatic tumors could modify the response of animals to a porphyrinogenic drug such as HCB. Thus, both female and male DENA/HBC rats accumulated more porphyrins and showed a lower delta-aminolevulinate synthase and uroporphyrinogen I synthase induction than HCB rats. e) The heme pathway was functional in DENA induced tumors in both male and female rats but they were little affected by HCB.
Wainstok de Calmanovici
R
R
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Cochón
A C
AC
Aldonatti
C
C
Cabral
J R
JR
San Martín de Viale
L C
LC
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000818:Animals; D002262:Carboxy-Lyases; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004052:Diethylnitrosamine; D005260:Female; D005294:Ferrochelatase / Q000378:metabolism; D006418:Heme / Q000378:metabolism*; D006581:Hexachlorobenzene; D011163:Hydroxymethylbilane Synthase / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D008297:Male; D011164:Porphyrias / Q000139:chemically induced / Q000201:enzymology*; D011166:Porphyrins / Q000378:metabolism*; D051381:Rats; D012727:Sex Characteristics
D011166:Porphyrins; D004052:Diethylnitrosamine; D006418:Heme; D006581:Hexachlorobenzene; D003577:Cytochrome P-450 Enzyme System; D000624:5-Aminolevulinate Synthetase; D011163:Hydroxymethylbilane Synthase; D002262:Carboxy-Lyases; C022430:porphyrinogen carboxy-lyase; D005294:Ferrochelatase