The state of leucocyte adhesiveness/aggregation (LAA) in the peripheral blood of burned mice: an early and sensitive inflammatory indicator and a marker of pulmonary leukostasis.
The inflammatory response during thermal injury increases the adhesiveness of white blood cells. A direct slide test was used to compare the state of leucocyte adhesiveness/aggregation (LAA) in the peripheral blood of mice subjected to a thermal injury with the findings in control animals. The state of LAA in the peripheral blood increased from baseline values of 1.1 +/- 1.1 per cent to 6.5 +/- 1.3 per cent within 1 h and to 11.0 +/- 1.2 per cent and 14.8 +/- 4 per cent after 3 and 6 h respectively following thermal injury. The respective leucocyte counts were 3075 +/- 277/mm3 (baseline), 3871 +/- 359, 3840 +/- 687 and 6395 +/- 1152 cells/mm3. The LAA values had subsided by 5 days following burning and correlated with the degree of pulmonary leukostasis. Our study suggests that the LAA is an early and sensitive marker of inflammation and that it can be used as a marker for the presence of pulmonary leukostasis during thermal injury.
Fried
M
M
Department of Plastic and Maxillofacial Surgery, Shaare Zedek Medical Center, Jerusalem, Israel.
Ben-Hur
N
N
Berliner
S
S
Medalia
O
O
Aronson
M
M
Kidron
D
D
Ben-Bassat
M
M
D000818:Animals; D001831:Body Temperature / Q000502:physiology; D002056:Burns / Q000097:blood* / Q000473:pathology; D002448:Cell Adhesion; D002449:Cell Aggregation; D005260:Female; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology*; D007964:Leukocytosis / Q000473:pathology*; D008171:Lung Diseases / Q000473:pathology*; D051379:Mice