title: A lack of effect of captopril on platelet aggregation in patients with congestive heart failure.
abstract: We have studied the acute and chronic effects of an ACE inhibitor (captopril) on platelet function and the renin-angiotensin system in patients with congestive heart failure. Plasma concentrations of angiotensin II fell significantly after a single dose of captopril (25 mg) and during long-term treatment with captopril (2 weeks, 75 mg/day). Plasma renin activity increased significantly after both the single and repeated doses. Captopril did not affect ADP-induced platelet aggregation or concentrations. It seems unlikely that circulating angiotensin II affects ADP-induced platelet aggregation in patients with congestive heart failure.
authors.affiliation: Department of Medicine, Western General Hospital, Edinburgh, UK.
authors.forename: I F
authors.initials: IF
authors.lastname: Gow
authors.forename: A D
authors.initials: AD
authors.lastname: Flapan
authors.forename: M
authors.initials: M
authors.lastname: Morris
authors.forename: E
authors.initials: E
authors.lastname: Davies
authors.forename: B C
authors.initials: BC
authors.lastname: Williams
authors.forename: P L
authors.initials: PL
authors.lastname: Padfield
authors.forename: T R
authors.initials: TR
authors.lastname: Shaw
authors.forename: C R
authors.initials: CR
authors.lastname: Edwards
mesh_terms: D000804:Angiotensin II / Q000097:blood; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D012083:Renin / Q000097:blood; D012701:Serotonin / Q000097:blood
chemical_list: D000804:Angiotensin II; D012701:Serotonin; D002216:Captopril; D012083:Renin