title: [Factor D of complement: Uremic toxin?].
abstract: Factor D is an essential enzyme of the alternative pathway of complement. Its catabolism is mainly renal. The concentration of factor D increases with renal failure, and is approximately 10-fold higher in patients with end-stage renal disease. The accumulation of factor D is responsible for an enhancement of alternative pathway activation. Whether this excess of factor D has pathophysiological consequences remains to be determined, however, complement activation might participate in adverse effects during hemodialysis and in the progression of renal injury.
authors.forename: M
authors.initials: M
authors.lastname: Pascual
mesh_terms: D011416:Complement Factor D / Q000378:metabolism*; D003170:Complement Pathway, Alternative; D006801:Humans; D014511:Uremia / Q000378:metabolism*
chemical_list: C493488:CFD protein, human; D011416:Complement Factor D
vernacular_title: Le facteur D du complément: toxine urémique?