[Studies on the mutagenicity of vesnarinone].
The mutagenicity of domestic Vesnarinone (OPC-8212) was studied by Ames test, micronucleus test of NIH mouse bone marrow and chromosome aberration assay in CHL cells. Negative results were obtained, which suggested that OPC-8212 did not induce prokaryotic cell gene mutation or chromosome damage both in vitro and in vivo.
Hu
H
H
Department of Biology and Cell Biology.
Xing
Y
Y
Tao
D
D
Zheng
X
X
Yang
Z
Z
D000818:Animals; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D011719:Pyrazines; D011804:Quinolines / Q000633:toxicity*
D011719:Pyrazines; D011804:Quinolines; C041667:vesnarinone