[Application of quantitative autoradiography to the measurement of brain function activity in rats during post-natal development].
Quantitative autoradiographic techniques for the measurement of local cerebral functional activity have been set up in the rat during postnatal development and applied to the measurement of local cerebral glucose and beta-hydroxybutyrate utilization as well as of local cerebral blood flow from 10 to 35 days after birth. These techniques have shown transient peaks of cerebral activity for both energy metabolism, expressed in terms of glucose plus beta-hydroxybutyrate utilization, and blood flow from 14 to 17 days of postnatal age. These methods which allow the mapping of functional activity simultaneously in all cerebral regions of conscious animals represent a tool of choice for the study of metabolism and blood flow regional changes, particularly in pathological situations.
Nehlig
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A
INSERM U272, Université de Nancy I, France.
Pereira de Vasconcelos
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A
Boyet
S
S
D020155:3-Hydroxybutyric Acid; D000818:Animals; D001345:Autoradiography / Q000379:methods; D001921:Brain / Q000000981:diagnostic imaging / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D002560:Cerebrovascular Circulation; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D006885:Hydroxybutyrates / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats
D006885:Hydroxybutyrates; D005947:Glucose; D020155:3-Hydroxybutyric Acid
Application de l'autoradiographie quantitative à la mesure de l'activité fonctionnelle cérébrale chez le rat au cours du développement postnatal.