title: Effects of cadmium on cocaine-induced changes in activity.
abstract: Adult male rats were exposed to a diet that contained 100 parts per million added cadmium or a control diet for 72 days before being tested in a Digiscan activity monitor. During the 1-hr test period, each animal's baseline activity levels were recorded for 20 min. Animals then received intraperitoneal injections of 0, 10, 20, or 40 mg/kg cocaine HCl, and their activity levels were recorded for the remaining 40 min of the test session. The results showed that the 10, 20, and 40 mg/kg doses of cocaine produced behavioral activation in the control-diet animals. For cadmium-treated animals, cocaine-induced behavioral changes at the 10 mg/kg dose were not observed, but increased activity was evident at the two higher doses.
authors.affiliation: Department of Psychology, Texas A&M University, College Station 77843.
authors.forename: J R
authors.initials: JR
authors.lastname: Nation
authors.forename: C A
authors.initials: CA
authors.lastname: Grover
authors.forename: J A
authors.initials: JA
authors.lastname: Salinas
authors.forename: C K
authors.initials: CK
authors.lastname: Pugh
authors.forename: R
authors.initials: R
authors.lastname: Peltier
authors.forename: B A
authors.initials: BA
authors.lastname: Horger
authors.forename: G D
authors.initials: GD
authors.lastname: Bratton
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats
chemical_list: D002104:Cadmium; D003042:Cocaine