title: [General pathogenesis of diffuse alveolar-interstitial pulmonary disease].
abstract: Diffuse alveolar-interstitial lung disease is a syndrome characterized, amongst others, by a common pathogenic scheme. The different phases of its pathogenesis are reviewed in this work. First of all, the concept of alveolitis is described, indicating its characteristics and general consequences of this lesion. Secondly, the different agents which could lead to the destruction of alveolar and interstitial structures, especially those of macrophagic origin, are reviewed. Next, the different types of granulomas, cells of which they are formed, and their general production mechanism are described. Finally the concept of lung fibrosis are reviewed, studying the different processes which lead to increased collagen in the interstitial tissue, specially chemotaxis and fibroblastic proliferative factors.
authors.affiliation: Servicio de Medicina Interna II (Cátedra de Patología General), Hospital Clínico Universitario, Salamanca.
authors.forename: J L
authors.initials: JL
authors.lastname: Pérez Arellano
authors.forename: J E
authors.initials: JE
authors.lastname: Losa García
authors.forename: M J
authors.initials: MJ
authors.lastname: García Martín
authors.forename: M C
authors.initials: MC
authors.lastname: Alcázar Montero
authors.forename: J D
authors.initials: JD
authors.lastname: García Palomo
authors.forename: A
authors.initials: A
authors.lastname: Jiménez López
mesh_terms: D006801:Humans; D011658:Pulmonary Fibrosis / Q000378:metabolism* / Q000503:physiopathology*
vernacular_title: Patogenia general de la enfermedad pulmonar alveolo-intersticial difusa.