Red blood cell polyamine evolution during normal growth in mouse.
Red blood cell (RBC) polyamine levels were studied at different ages in growing mice. Contrary to RBC from adult mice, high levels of the three polyamines Putrescine, Spermidine (Spd), Spermine (Spm) were detected in erythrocytes from newborn mice. These levels progressively decreased during growth. As previously reported in experimental and clinical studies related to tumor progression or normal tissue regeneration, a statistical correlation between Spd and Spm was noticed in this study concerning normal growth. As regards this correlation, two separate periods appeared during development. The slope values of the straight regression line were calculated for these periods and showed highly significant differences.
Quemener
V
V
Unité Fonctionelle de Biologie Cellulaire, CNRS SDI 15667, Centre Hospitalier Universitaire, Rennes, France.
Martin
C
C
Havouis
R
R
Moulinoux
J P
JP
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D004912:Erythrocytes / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D011073:Polyamines / Q000097:blood*; D013095:Spermidine / Q000097:blood; D013096:Spermine / Q000097:blood
D011073:Polyamines; D013096:Spermine; D013095:Spermidine