title: Quantitative and sustained suppression of renal sympathetic nerve activity by left atrial distension in conscious dogs.
abstract: In order to investigate the interrelations between left atrial pressure (Pla) and renal sympathetic nerve activity (RSNA) and heart rate (HR), Pla was increased by a balloon both in conscious sham-operated and cardiac-denervated dogs. RSNA was decreased and HR was increased with increasign Pla in sham-operated dogs. The reflex changes in RSNA and HR induced by the stimulation of atrial receptors persisted for at least 15 min. There was a consistent relationship between Pla and RSNA which could be described by a single exponential equation: % delta RSNA = -80.0(1-e-0.395 delta Pla), or by a linear equation when delta Pla was less than 6 mmHg; % delta RSNA = -13.5 delta Pla-2.25. The relationship between Pla and HR can be described by a single exponential equation: delta HR = 86.5(1-e-0.125 delta Pla). A significant linear relationship between RSNA and HR was obtained during a graded left atrial distention (% delta RSNA = -1.08 delta HR-17.7). In cardiac-denervated dogs, RSNA tended to increase and HR remained constant during the left atrial distention. These results indicate that left atrial receptors regulate RSNA and HR in both a quantitative and sustained manner in conscious sham-operated dogs.
authors.affiliation: Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Kitakyushu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Miki
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashida
authors.forename: K
authors.initials: K
authors.lastname: Shiraki
mesh_terms: D000818:Animals; D016275:Atrial Function; D001794:Blood Pressure / Q000502:physiology; D003714:Denervation; D004285:Dogs; D005260:Female; D006321:Heart / Q000294:innervation*; D006325:Heart Atria / Q000294:innervation; D006339:Heart Rate / Q000502:physiology; D007668:Kidney / Q000294:innervation*; D008465:Mechanoreceptors / Q000502:physiology; D012018:Reflex / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*