[A preclinical study of the organ distribution and radiation dosage of radioiodinated iodolisuride].
The distribution in rats of 125I-iodo-lisuride was studied. Three rats each were sacrificed at fixed intervals between 5 min and 24 h p.i., and the radioactivity was measured in isolated organs and parts of the body. The organ distribution and biexponential blood disappearance were similar to values for unlabeled lisuride. The radiation dose was estimated for man assuming a 123I label. The resulting doses were comparable to those from other radiopharmaceuticals in clinical use.
Buchali
K
K
Klinik für Nuklearmedizin, Fakultät (Charité), Humboldt-Univ., Berlin, FRG.
Flade
H
H
Johannsen
B
B
Pink
V
V
Herold
U
U
Harhammer
R
R
Horowski
R
R
D000818:Animals; D007457:Iodine Radioisotopes; D008090:Lisuride / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008297:Male; D011829:Radiation Dosage; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D008090:Lisuride
Vorklinische Untersuchung zur Organverteilung und Strahlenbelastung von Radiojod-Jodlisurid.