The concentration of the cross-linking agent as a tool for the control of release and swelling properties of gelatin microspheres.
The effect of the concentration of a cross-linking agent (gelatin hardener) on gelatin microspheres was evaluated. A concentration increase of the gelatin hardener (formaldehyde) produced a decrease of drug loading, swelling degree and drug release rate. The cross-linking agent concentration affected also the kinetics of water absorption and drug release. This paper suggests a decreasing significance of the diffusion-type mechanism of drug release as the concentration of the cross-linking agent increased.
Vandelli
M A
MA
Department of Pharmaceutical Sciences, University of Modena, Italy.
Forni
F
F
Iannuccelli
V
V
Cameroni
R
R
D002214:Capsules / Q000737:chemistry*; D003432:Cross-Linking Reagents; D005780:Gelatin / Q000737:chemistry*
D002214:Capsules; D003432:Cross-Linking Reagents; D005780:Gelatin