Expression of c-myc in cutaneous lymphomas and pseudolymphomas.
The expression of the proto-oncogene c-myc was studied in tumorous skin lesions of (cutaneous) lymphoproliferative diseases (3 cases of pseudolymphoma, 8 cases of non-Hodgkin lymphoma and 1 case of lymph node involvement in mycosis fungoides) in a total of 12 patients. c-myc mRNA levels were quantified by Northern blot analysis followed by densitometric evaluation of the specific bands. Higher levels of c-myc mRNA expression were observed in lymphomas as compared with pseudolymphomas (p greater than 0.05). No significant differences in c-myc mRNA values were detected between B and T cell pseudolymphomas. Our results suggest that c-myc mRNA overexpression is associated with malignant lymphomas of the skin. We conclude that the measurement of c-myc mRNA levels may contribute to further characterize cutaneous lymphoproliferative diseases.
Peris
K
K
Department of Dermatology, University of L'Aquila, Italy.
Cerroni
L
L
Kerl
H
H
Radaszkiewicz
T
T
Chimenti
S
S
Höfler
H
H
D015152:Blotting, Northern; D006801:Humans; D008223:Lymphoma / Q000235:genetics* / Q000276:immunology; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D012878:Skin Neoplasms / Q000235:genetics* / Q000276:immunology
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger