Metastatic calcification due to hypercalcemia in adult T-cell leukemia-lymphoma (ATLL).
Four cases of metastatic calcification due to hypercalcemia in adult T-cell leukemia-lymphoma (ATLL) are reported. Serum calcium was at high levels, 15.4-19.4 mg/dl (normal range 8.4-10.4 mg/dl). In our cases, metastatic calcification was detected by v. Kossa's silver nitrate method for calcium in tubules of kidneys (100%), pulmonary alveolar septa of lungs (100%), myocardium (75%), muscular layer of stomach (50%), lower portion of aortic media (50%), gastric mucosa (25%), testicular tubules (25%), and in the liver (25%). Scattered osteoclasts were seen around the cortex of the bone. Therefore, hypercalcemia in ATLL may have been caused by bone-resorption-stimulating factors which promote differentiation of osteoclast cells, resulting in calcium increase in the serum.
Senba
M
M
Department of Pathology, Nagasaki University, Japan.
Kawai
K
K
D000328:Adult; D000368:Aged; D001011:Aorta / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D002114:Calcinosis / Q000209:etiology* / Q000473:pathology; D009202:Cardiomyopathies / Q000209:etiology / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000150:complications* / Q000209:etiology; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications*; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology; D008171:Lung Diseases / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology; D011650:Pulmonary Alveoli / Q000473:pathology; D013270:Stomach / Q000473:pathology; D013272:Stomach Diseases / Q000209:etiology / Q000473:pathology; D013733:Testicular Diseases / Q000209:etiology / Q000473:pathology; D013737:Testis / Q000473:pathology