title: Brain tumours and the occurrence of severe invasive basal cell carcinoma in first degree relatives with Gorlin syndrome.
abstract: We describe the occurrence of a medulloblastoma and an astrocytoma in successive generations of a family with the Gorlin syndrome. The appearance of thousands of invasive basal cell carcinomata after craniospinal irradiation led to the death of one patient from intracranial involvement.
authors.affiliation: CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK.
authors.forename: D G
authors.initials: DG
authors.lastname: Evans
authors.forename: J M
authors.initials: JM
authors.lastname: Birch
authors.forename: C I
authors.initials: CI
authors.lastname: Orton
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000473:pathology; D001478:Basal Cell Nevus Syndrome / Q000235:genetics* / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002280:Basal Cell Carcinoma / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000473:pathology / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology