Derivative spectrophotometric determination of antiprotozoal drugs in two-component tablet preparation.
First (D1-) and second (D2-) derivative spectrophotometric methods for the determination of diloxanide furoate and metronidazole in two-component preparation are presented. The methods are based on the direct measurements of diloxanide furoate in 0.1N hydrochloric acid solution at 262 nm and 248 nm for D1- and D2- curves, respectively without the interference of the coexisting component. Metronidazole, on the other hand is determined before and after its acid extraction from chloroformic solution and the subsequent D1- measurement at 288 nm and D2- measurement at 296 nm. The methods have been applied for the determination of both components in laboratory made mixtures and in tablet with a coefficient of variation less than 2%.
Galal
S M
SM
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
Bedair
M M
MM
el-Sayed
M A
MA
D000981:Antiprotozoal Agents / Q000032:analysis*; D004338:Drug Combinations; D005663:Furans / Q000032:analysis; D008795:Metronidazole / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000981:Antiprotozoal Agents; D004338:Drug Combinations; D005663:Furans; D013607:Tablets; D008795:Metronidazole; C004932:diloxanide furoate