The effects of oral morphine and buprenorphine on autotomy following brachial nerve sections in rat.
This study assessed the relationship between autotomy and opioid systems following brachial nerve sections in the rat. Morphine, buprenorphine and/or naloxone were self-administered orally to rats following nerve sections. Oral morphine and buprenorphine increased the severity of autotomy. Naloxone alone had no effect, but reversed oral morphine effect on autotomy. These results suggest that mu-receptor activation by morphine and buprenorphine can increase the severity of autotomy.
Yamamoto
Tatsuo
T
Department of Anesthesiology, School of Medicine, Chiba University, Chiba 280 Japan.
Mizuguchi
Tadanobu
T
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001917:Brachial Plexus / Q000601:surgery*; D002047:Buprenorphine / Q000008:administration & dosage* / Q000494:pharmacology; D003714:Denervation / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D008297:Male; D009020:Morphine / Q000008:administration & dosage* / Q000494:pharmacology; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D010146:Pain / Q000209:etiology / Q000503:physiopathology*; D051381:Rats; D011916:Rats, Inbred F344; D012652:Self Mutilation
D009270:Naloxone; D002047:Buprenorphine; D009020:Morphine