Uptake of fluorine in cortical and trabecular bone.
Nuclear magnetic resonance techniques can measure the fluoride levels in bone of the finger after a patient has ingested F in the treatment of osteoporosis, but does uptake in cortical bone reflect uptake in the critical trabecular bone? Investigation has been made of the relative uptake of fluoride from drinking water into trabecular and cortical bone of the rat. For fine detail of the uptake of F into the femur and vertebra, microprobe techniques were used with a spatial resolution of 10 microns; for broader studies, treating the femur as representative of cortical bone and the vertebra as typical of trabecular bone, chemical techniques using spectroscopy and ion-selective electrodes were employed. The conclusion is that in the rat uptake of F by cortical bone is indicative of uptake by trabecular bone, and that therefore as a working hypothesis NMR measurement of F in the finger may be taken as reflecting uptake of F by trabecular bone.
McNeill
K G
KG
Department of Physics, University of Toronto, Ontario, Canada.
Coote
G E
GE
Hitchman
A J
AJ
D000818:Animals; D001345:Autoradiography; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000032:analysis; D005260:Female; D005269:Femur; D005461:Fluorine / Q000032:analysis / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D011919:Rats, Inbred Strains; D013131:Spine
D005461:Fluorine; D002118:Calcium