The effect of methamphetamine on the release of glutamate from striatal slices.
One postulated role of dopamine in the striatum is to reduce neuronal activity in cortico-striatal glutamergic terminals. We investigated the effects of methamphetamine, which displaces dopamine, on glutamate release from rat striatal slices. Methamphetamine significantly reduced K(+)-stimulated (45 mM) glutamate release. In slices prepared from rats treated 8 days previously with methamphetamine there was enhanced (approximately 200%) release of glutamate. This study demonstrates that dopamine has a modulatory effect on glutamate release in the striatum.
Earle
M L
ML
Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Cardiff, United Kingdom.
Davies
J A
JA
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005971:Glutamates / Q000378:metabolism*; D066298:In Vitro Techniques; D008694:Methamphetamine / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D005971:Glutamates; D008694:Methamphetamine; D011188:Potassium; D004298:Dopamine