title: Biological changes in the regenerating and intact rat liver following exposure of the organ to lasers.
abstract: This study is among the first employing anatomical partial hepatectomy and exposure of the remnant organ to lasers before closure for comparison of biological changes with those of exposed sham-operated groups and the respective controls. Adult male rats were partially hepatectomized leading to removal of two-thirds of the organ and the lateral lobe exposed to Argon (514 nm, 270 mW-3.0 W for up to 120 s; tunable dye, 630 nm, 200 and 500 mW for up to 240 s) and Nd:YAG (1064 nm; 3-8 W, 60-180 s) lasers. Sham-operated rats were treated similarly and with several, 1 or 2 additional sites in the quadrate lobes were irradiated. Possibly, liver damage and penetrability were somewhat greater for the intact rats treated with the Nd:YAG laser and which also displayed liver profile changes over the controls in contrast to the partially hepatectomized. In general, the extent of liver regeneration over a period of 10 days post-operative was not affected by the laser treatment. The mixed function oxidase system reflected small decrements in aminopyrine demethylase and in benzo[a]pyrene hydroxylase for adjacent lesion-free microsomes from the partially hepatectomized and intact groups exposed to Nd:YAD laser (5.0 W, 120 s), respectively.
authors.affiliation: Northwest Institute for Medical Research, John F. Kennedy Health Care Corporation, Chicago, IL.
authors.forename: L L
authors.initials: LL
authors.lastname: Gershbein
authors.forename: R W
authors.initials: RW
authors.lastname: Denton
authors.forename: M J
authors.initials: MJ
authors.lastname: Schifano
mesh_terms: D000818:Animals; D006498:Hepatectomy; D007834:Lasers / Q000009:adverse effects*; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000473:pathology / Q000528:radiation effects*; D008115:Liver Regeneration; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000528:radiation effects; D009929:Organ Size / Q000528:radiation effects; D051381:Rats; D011919:Rats, Inbred Strains; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D008055:Lipids