title: A series of experimental surgery for advanced Parkinson's disease by foetal mesencephalic transplantation.
abstract: 12 patients with advanced Parkinson's Disease who had right caudate implantations of late stage foetal mesencephalon have been followed up for 1 to 2 years with extensive clinical and physiological assessments. Three patients failed to comply and were excluded. Seven of the remaining 9 patients showed substantial initial improvement which was well maintained in 4. Two of the 3 remaining patients of this group maintained lesser improvement. One returned to pre-operative state. Two patients with greatly advanced disease had only slight but brief improvement. A series of 24 matched patients have been treated and continue under investigation.
authors.affiliation: Department of Neurosurgery, University of Birmingham, Midland Centre for Neurosurgery and Neurology, Smethwick, Birmingham, U.K.
authors.forename: E R
authors.initials: ER
authors.lastname: Hitchcock
authors.forename: B G
authors.initials: BG
authors.lastname: Kenny
authors.forename: B T
authors.initials: BT
authors.lastname: Henderson
authors.forename: C G
authors.initials: CG
authors.lastname: Clough
authors.forename: R C
authors.initials: RC
authors.lastname: Hughes
authors.forename: A
authors.initials: A
authors.lastname: Detta
mesh_terms: D000328:Adult; D000368:Aged; D016380:Brain Tissue Transplantation / Q000379:methods*; D002421:Caudate Nucleus / Q000601:surgery*; D005260:Female; D016332:Fetal Tissue Transplantation / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000196:embryology / Q000637:transplantation*; D008875:Middle Aged; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000601:surgery*; D010865:Pilot Projects; D011183:Postoperative Complications / Q000601:surgery*; D011699:Putamen / Q000601:surgery*