title: [Combined arterial bypass operation and coumarin therapy--a concept for long-term management and its conditions].
abstract: Antithrombotics of cumarin type or with antiplatelet effect are preferred to obtain results from vascular surgical interventions in arterial occlusion disease. In our experience the combination with cumarin long term therapy seems to be the better method, especially if the following conditions can be achieved: very good compliance of patients respectively strict consideration of absolute and relative contraindications, a sufficient number of patients who are treated and a long enough experience of therapeutists followed by using the recommendations of the WHO expert committee for the worldwide application of standardization in measuring the anticoagulation effect, using reagents and calibration materials, and the expression of results in INR. Further in our anticoagulation behaviour we are used influencing risk factors, having a good cooperation between patients and doctors during secondary diseases and new drug intake. For dental surgery we prefer a Quick test between 30 and 35% activity or 1, 9 and 2, 1 INR. With Phenprocoumon (Falithrom, Markumar) we use the long term anticoagulation effect without several daily applications. Since September 1987 there has been the possibility of a computer assisted programme for dose prediction.
authors.affiliation: Zentralabteilung Hämostaseologie/Angiologie und Gefässchirurgische Klinik Berlin.
authors.forename: L
authors.initials: L
authors.lastname: Kühnel
authors.forename: C
authors.initials: C
authors.lastname: Heinrichs
authors.forename: I
authors.initials: I
authors.lastname: Wache
authors.forename: J
authors.initials: J
authors.lastname: Neugebauer
mesh_terms: D000328:Adult; D001012:Aorta, Abdominal / Q000601:surgery; D001014:Aortic Aneurysm / Q000601:surgery; D001157:Arterial Occlusive Diseases / Q000188:drug therapy / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D003131:Combined Modality Therapy; D003374:Coumarins / Q000008:administration & dosage*; D006801:Humans; D007511:Ischemia / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged
chemical_list: D003374:Coumarins; C030123:coumarin
vernacular_title: Kombinierte arterielle Bypass-Chirurgie und Kumarintherapie--ein Konzept zur Langzeitbetreuung und seine Bedingungen.