[Characteristics of the course of chronic liver diseases of hepatitis B etiology with delta infection in children].
Overall 120 children with chronic liver diseases of HB-virus etiology were examined. In 78.3% of the patients, RIA was used to reveal anti-delta in blood serum, 33 children were diagnosed to have chronic persistent hepatitis, 44 chronic active hepatitis, and 43 liver cirrhosis. The patients with anti-delta manifested certain characteristic features. There prevailed children from epidemiologically unfavourable regions as regards virus hepatitis B. There also prevailed boys. In one-third of the patients with chronic liver diseases and anti-delta, acute hepatitis ran a biphasic course. According to the data obtained, super-addition of delta-infection aggravates the disease; the process becomes chronic more rapidly, exacerbations are more pronounced. 16 out of 23 children showed delta-antigen in liver biopsy specimens; in patients with active disease, the antigen was detected in the nucleus and cytoplasm at a time. As the activity decreases, the antigen becomes mostly detectable in the cytoplasm.
Chistova
L V
LV
Ivanov
V G
VG
Khodunova
T V
TV
Sakhatov
M Ia
MIa
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000032:analysis / Q000276:immunology; D006511:Hepatitis B Antigens / Q000276:immunology; D003699:Hepatitis D / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D003698:Hepatitis Delta Virus / Q000276:immunology; D006521:Hepatitis, Chronic / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D006801:Humans; D008297:Male
D000914:Antibodies, Viral; D015415:Biomarkers; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens
Osobennosti techeniia khronicheskikh zabolevaniĭ pecheni HB-virusnoĭ étiologii s delta-infektsieĭ u deteĭ.