title: Bactericidal activity of ceftizoxime, cefotetan, and clindamycin against cefoxitin-resistant strains of the Bacteroides fragilis group.
abstract: The bactericidal activity of ceftizoxime, cefotetan, and clindamycin at 0.5 x MIC, 1 x MIC, and 4 x MIC was determined by killing kinetic studies for 12 cefoxitin-resistant strains of the Bacteroides fragilis group. Ceftizoxime and clindamycin had greater bactericidal activity than cefotetan. The degree of bactericidal activity of each compound increased as the concentration increased from subinhibitory (0.5 x MIC) to suprainhibitory concentrations (4 x MIC). Comparison of the bactericidal activity at the MIC of the test agents with the MIC showed greater killing of susceptible strains than the resistant strains. Interestingly, ceftizoxime was more active than clindamycin, or cefotetan, against strains with high cefoxitin MIC values.
authors.affiliation: Louisiana State University Medical Center, New Orleans.
authors.forename: K E
authors.initials: KE
authors.lastname: Aldridge
authors.forename: C W
authors.initials: CW
authors.lastname: Stratton
mesh_terms: D001441:Bacteroides fragilis / Q000187:drug effects*; D015313:Cefotetan / Q000494:pharmacology*; D015296:Ceftizoxime / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests
chemical_list: D002981:Clindamycin; D015313:Cefotetan; D015296:Ceftizoxime