title: Purpura simplex (inflammatory purpura without vasculitis): a clinicopathologic study of 174 cases.
abstract: Purpura simplex manifests clinically as macular purpuric and petechial pigmented, golden, annular, or lichenoid lesions. These subtypes have been termed Schamberg's purpura, lichen aureus, Majocchi's purpura, and Gougerot-Blum purpura. Histologically, there is inflammation and hemorrhage without fibrinoid necrosis of vessels. One hundred seventy-four cases were retrospectively reviewed. In some patients, the eruption was related to medications. Treatment was usually of limited benefit. Fifty-eight of 87 patients (67%) who had follow-up data did eventually have clearing of lesions. Because of the clinical and histologic similarities among the subtypes, the inclusive term purpura simplex is favored.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
authors.forename: K V
authors.initials: KV
authors.lastname: Ratnam
authors.forename: W P
authors.initials: WP
authors.lastname: Su
authors.forename: M S
authors.initials: MS
authors.lastname: Peters
mesh_terms: D004485:Eczema / Q000473:pathology; D004912:Erythrocytes / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006485:Hemosiderin / Q000032:analysis; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000473:pathology; D011693:Purpura / Q000139:chemically induced / Q000209:etiology / Q000473:pathology*; D012189:Retrospective Studies; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D006485:Hemosiderin