[Calcificated necrotic inflammatory granuloma after intradiscal injection of triamcinolone hexacetonide].
Recently, it has been demonstrated that symptomatic epidural calcifications represent a complication of intradiscal injection of triamcinolone hexacetonide (Hexatrione). Out of our three cases, pathological examination showed lesions of necrosis with granulomatous inflammatory reaction and bone metaplasia. Necrosis seems to be the primary cause of calcifications so we propose to call the lesion inflammatory and necrotic granuloma. The incidence of these granulomas is unknown. They are unpredictable and appear with a mean range of a year following the intradiscal injection. The treatment is surgery if they become symptomatic.
Menei
P
P
Service de Neurochirurgie, Centre hospitalier Régional et Universitaire, Angers.
Fournier
D
D
Alhayek
G
G
Mercier
P
P
François
H
H
Audran
M
M
Guy
G
G
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002114:Calcinosis / Q000139:chemically induced*; D005260:Female; D006099:Granuloma / Q000139:chemically induced*; D006801:Humans; D007404:Intervertebral Disc Chemolysis; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced*; D013122:Spinal Diseases / Q000139:chemically induced; D013166:Spondylitis / Q000139:chemically induced*; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
D000893:Anti-Inflammatory Agents; D014222:Triamcinolone Acetonide; C005900:triamcinolone hexacetonide
Granulome nécrotico-inflammatoire calcifié après nucléorthèse à l'hexacétonide de triamcinolone.