title: A magnetic resonance image study of age-related changes in human putamen nuclei.
abstract: Putamen nuclei were assessed in 36 normal volunteers using magnetic resonance imaging and a systematic sampling method. There was a significant decrease in the volume of the putamen nuclei with advancing age (r = -0.74, p less than 0.0001), and an associated decline in the volume of the caudate nuclei (r = 0.60, p less than 0.0001). The implications of these findings in age-associated motor abnormalities are discussed.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: W M
authors.initials: WM
authors.lastname: McDonald
authors.forename: M
authors.initials: M
authors.lastname: Husain
authors.forename: P M
authors.initials: PM
authors.lastname: Doraiswamy
authors.forename: G
authors.initials: G
authors.lastname: Figiel
authors.forename: O
authors.initials: O
authors.lastname: Boyko
authors.forename: K R
authors.initials: KR
authors.lastname: Krishnan
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D002421:Caudate Nucleus / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011699:Putamen / Q000033:anatomy & histology*; D012016:Reference Values