title: [Platelet aggregation during hypotensive anesthesia using prostaglandin E1].
abstract: We studied platelet aggregation during hypotensive anesthesia using prostaglandin E1 (PGE1) on 22 patients (6 males, 16 female). All the patients underwent operations on head, neck, abdomen, breast, or lower extremities under general anesthesia. They had no history of hematological disease or taking drugs which affected platelet aggregation. The blood was sampled three times under a constant condition of anesthesia with intravenous drip: firstly, before using PGE1, secondly, under hypotensive state during PGE1 infusion at the speed of 0.05-0.3 micrograms.kg-1.min-1, and thirdly, after cessation of PGE1, after the blood pressure had recovered to the level before PGE1 infusion. ADP, collagen and epinephrine were added to the platelet rich plasma as clumping agents; their final concentrations were 0.3 microM, 2 micrograms.ml-1, and 2 micrograms.ml-1 respectively. The aggregating curves were recorded for 7 min. There were no significant differences in platelet aggregation among the three blood samples; neither in platelet count nor in bleeding time. Bleeding did not seem to have increased due to PGE1 infusion. These results suggest that PGE1 at hypotensive dose could be used safely under general anesthesia regarding hemostasis.
authors.affiliation: Department of Anesthesiology, Kyoto Prefectural University of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Hosokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
mesh_terms: D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007023:Hypotension, Controlled; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D013514:Surgical Procedures, Operative
chemical_list: D000527:Alprostadil