Expression of APP in the early stage of brain damage.
We immunocytochemically studied the expression of various epitopes of amyloid beta/A4 protein precursor (APP) after brain damage by kainic acid injection. After 3 h, APP695 rapidly accumulated in dystrophic neurites near the damaged site. After 3 days, APP with Kunitz-type protease inhibitor domain was expressed in reactive astrocytes in the lesion and ipsilateral hippocampus. APP rapidly accumulated in dystrophic neurites, and different types of APP were expressed in different cell types in the damaged brain.
Kawarabayashi
T
T
Department of Neurology, Gunma University School of Medicine, Maebashi, Japan.
Shoji
M
M
Harigaya
Y
Y
Yamaguchi
H
H
Hirai
S
S
D016229:Amyloid beta-Peptides / Q000096:biosynthesis* / Q000276:immunology; D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D007608:Kainic Acid; D008297:Male; D009457:Neuroglia / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D014360:Trypsin Inhibitor, Kunitz Soybean
D016229:Amyloid beta-Peptides; D014360:Trypsin Inhibitor, Kunitz Soybean; D007608:Kainic Acid