Age- and sex-related effects on hepatic drug metabolism in rats chronically exposed to dietary atrazine.
Male and female Wistar rats were administered a diet containing 450 ppm atrazine as early as 60 days prior to the cohabitation period and the same diet was offered to their offspring. Hexobarbital sleeping time and further in vitro assays pointed to a monooxygenase induction which appeared to be more marked in males vs females and most significant in the offspring at weaning. At this age, induction involved also the cytosolic glutathione S-transferase, a phase II enzyme. Results would suggest that the inducing properties of the herbicide can be transferred to the offspring via the placental and/or the mammary route.
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Dipartimento di Medicina e Oncologia Sperimentale, Università di Torino, Italy.
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D000367:Age Factors; D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D001280:Atrazine / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004790:Enzyme Induction; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism; D006591:Hexobarbital / Q000494:pharmacology*; D008297:Male; D008431:Maternal-Fetal Exchange; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects*
D000814:Aniline Compounds; D000632:Aminopyrine; D006591:Hexobarbital; D005982:Glutathione Transferase; D001280:Atrazine; C023650:aniline