Effects of prostaglandins and prostaglandin synthetase inhibitors on acutely obstructed kidneys in the dog.
An intact canine model was developed to study the effects of prostaglandins (PG) and prostaglandin synthetase inhibitors on acutely obstructed kidneys. Totally implanted nephrostomy tubes were placed to measure renal pelvic pressure. Complete ureteral obstruction was obtained with a Fogarty balloon catheter inflated in the distal ureter; by this method renal pelvic pressure reached 40-50 mm Hg. Renal pelvic pressure was reduced after intravenous indomethacin and dipyrone administration, whereas blood pressure showed no major changes. Exogenous prostaglandins had both immediate and contrary effects: PGE2 caused a significant decrease, whereas PGF2 alpha caused a significant increase in renal pelvic and blood pressure. The reduced rise in renal pelvic pressure appears to be the main reason for the analgesic effects of prostaglandin synthetase inhibitors. The efficiency of these drugs in the treatment of renal colic is supported by this study, that of prostaglandins cannot be proved.
Zwergel
U
U
Department of Urology, University of Saarland, Homburg/Saar, FRG.
Zwergel
T
T
Ziegler
M
M
D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003085:Colic / Q000188:drug therapy* / Q000209:etiology; D015237:Dinoprost / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology; D004177:Dipyrone / Q000494:pharmacology* / Q000627:therapeutic use; D004285:Dogs; D005260:Female; D007213:Indomethacin / Q000494:pharmacology* / Q000627:therapeutic use; D007674:Kidney Diseases / Q000188:drug therapy* / Q000209:etiology; D007682:Kidney Pelvis / Q000187:drug effects* / Q000503:physiopathology; D011312:Pressure; D014517:Ureteral Obstruction / Q000150:complications / Q000503:physiopathology*
D004177:Dipyrone; D015237:Dinoprost; D015232:Dinoprostone; D007213:Indomethacin