Synthesis and studies of alkynyl pyrimidinones as metaphase inhibitors.
Methods are described for the syntheses of chloromethyl propargyl ethers and propargyl halides substituted with a hydroxyalkyl group, and their use in alkylation reactions of 2-pyrimidinones. The N-alkynyl derivatives are reversible inhibitors of mitosis in the metaphase of the cell-cycle. The in vivo screening was on Chang liver cells.
Benneche
T
T
Department of Chemistry, University of Oslo, Norway.
Keilen
G
G
Solberg
J
J
Oftebro
R
R
Undheim
K
K
D000478:Alkylation; D002478:Cells, Cultured; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects; D008677:Metaphase / Q000187:drug effects*; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology
D011744:Pyrimidinones