Effects of cadmium on cocaine-induced changes in activity.
Adult male rats were exposed to a diet that contained 100 parts per million added cadmium or a control diet for 72 days before being tested in a Digiscan activity monitor. During the 1-hr test period, each animal's baseline activity levels were recorded for 20 min. Animals then received intraperitoneal injections of 0, 10, 20, or 40 mg/kg cocaine HCl, and their activity levels were recorded for the remaining 40 min of the test session. The results showed that the 10, 20, and 40 mg/kg doses of cocaine produced behavioral activation in the control-diet animals. For cadmium-treated animals, cocaine-induced behavioral changes at the 10 mg/kg dose were not observed, but increased activity was evident at the two higher doses.
Nation
J R
JR
Department of Psychology, Texas A&M University, College Station 77843.
Grover
C A
CA
Salinas
J A
JA
Pugh
C K
CK
Peltier
R
R
Horger
B A
BA
Bratton
G D
GD
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats
D002104:Cadmium; D003042:Cocaine