[The effect of the adamantylamides of 1,3-diphenylpyrazole-4-carboxylic acids on the cytochrome P-450 system of the liver].
The effect of adamanthylamides of 1,3-diphenylptrazol-4-carbonic acids on the system of the liver microsomal monoxygenases was studied. A potent induction of the liver cytochrome P-450 by 1,3-diphenylpyrazol-5-methyl-4-carbonic acid, N-methyl-N-(adamant-1-il)amide was found. As a consequence of the induction of the liver cytochrome P-450, the compound reduced by 40% the degree of the delayed type hypersensitivity in mice.
Khlopushina
T G
TG
Krinskaia
A V
AV
D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000577:Amides / Q000494:pharmacology; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000187:drug effects*; D004790:Enzyme Induction / Q000187:drug effects; D006968:Hypersensitivity, Delayed / Q000201:enzymology; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology
D000577:Amides; D003577:Cytochrome P-450 Enzyme System; D000547:Amantadine
Vliianie adamantilamidov 1,3-difenilpirazol-4-karbonovykh kislot na sistemu tsitokhroma P-450 pecheni.