title: Gas chromatography and mass spectrometry of dimethylethylsilyl ether derivatives of norethisterone metabolites in plasma.
abstract: Metabolites isolated from human plasma after oral administration of norethisterone were assayed as their novel dimethylethylsilyl ether derivatives by gas chromatography--mass spectrometry--ion selective monitoring. The major metabolite is 3 alpha, 5 alpha-tetrahydronorethisterone. The unchanged drug is present in a measurable amount even after 8 h of drug administration. The method is accurate, precise and highly sensitive.
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Egypt.
authors.forename: M S
authors.initials: MS
authors.lastname: Rizk
authors.forename: N A
authors.initials: NA
authors.lastname: Zakhari
authors.forename: M I
authors.initials: MI
authors.lastname: Walash
authors.forename: S S
authors.initials: SS
authors.lastname: Toubar
authors.forename: C J
authors.initials: CJ
authors.lastname: Brooks
authors.forename: R
authors.initials: R
authors.lastname: Anderson
mesh_terms: D004987:Ethers / Q000032:analysis; D005003:Ethisterone / Q000097:blood; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009640:Norethindrone / Q000097:blood / Q000378:metabolism*
chemical_list: D004987:Ethers; D005003:Ethisterone; D009640:Norethindrone