title: The value of an expert system in performing clinical drug trials.
abstract: An expert system has been designed to assist the cardiologist in determining whether patients can be included in clinical trials. This system contains knowledge on inclusion and exclusion criteria for six drug trials, and has been validated in 100 randomly selected patients. In 97 cases, the expert system and the cardiologist made an identical classification; in the remaining three cases, the patient was incorrectly classified by the physician. The system will also optimize the order in which questions are asked in order to minimize the time required to decide on inclusion or exclusion.
authors.affiliation: Department of Cardiology, University of Limburg, Maastricht, The Netherlands.
authors.forename: W R
authors.initials: WR
authors.lastname: Dassen
authors.forename: R
authors.initials: R
authors.lastname: Mulleneers
authors.forename: H L
authors.initials: HL
authors.lastname: Frank
mesh_terms: D000789:Angina, Unstable / Q000145:classification; D002986:Clinical Trials as Topic / Q000379:methods*; D003627:Data Interpretation, Statistical; D005103:Expert Systems; D006801:Humans; D009203:Myocardial Infarction / Q000145:classification; D015588:Observer Variation; D011655:Pulmonary Embolism / Q000145:classification; D013610:Tachycardia / Q000145:classification; D014584:User-Computer Interface