N-isopropyl-123I-p-iodoamphetamine uptake mechanism in the lung--is it dependent on pH, lipophilicity or pKa?
The uptake and binding mechanism of biogenic amines in the lungs has been studied extensively with no conclusive results. The competition between N-isopropyl-123I-p-iodo amphetamines (123I-IMP) and propranolol and 123I-IMP and ketamine, in the lungs suggest that the pKa value of the biogenic amines has a significant role to play in the mechanism of uptake and retention of biogenic amines in the lungs.
Akber
S F
SF
Department of Radiology, University of Texas Medical School, Houston.
D000662:Amphetamines / Q000493:pharmacokinetics*; D000818:Animals; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D007457:Iodine Radioisotopes; D020367:Iofetamine; D007649:Ketamine / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology
D000662:Amphetamines; D007457:Iodine Radioisotopes; D007649:Ketamine; D011433:Propranolol; D020367:Iofetamine