Changes in glucose metabolism in dementia of the Alzheimer type compared with depression: a preliminary report.
We evaluated positron emission tomography (PET) in the differential diagnosis of depression and Alzheimer's disease. The local cerebral metabolic rate for glucose (LCMRGlc) in the parahippocampal gyrus-hippocampus and the dorsolateral prefrontal cortex were determined. The ratio of the LCMRGlc in those two regions was examined in patients with unipolar depression, bipolar depression, and Alzheimer's dementia. An analysis of variance revealed significant overall intergroup differences in values for both hemispheres. Student's t test showed significant differences in LCMRGlc for both unipolar and bipolar depression as compared with Alzheimer's dementia. These data indicate that PET may be useful in the differential diagnosis of dementia vs. depression.
Guze
B H
BH
University of California, Los Angeles.
Baxter
L R
LR
Schwartz
J M
JM
Szuba
M P
MP
Mazziotta
J C
JC
Phelps
M E
ME
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D003866:Depressive Disorder / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D004734:Energy Metabolism / Q000502:physiology*; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D006624:Hippocampus / Q000000981:diagnostic imaging; D006801:Humans; D014055:Tomography, Emission-Computed
D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose