title: Bioactive polymers 66. Theophylline retardation in xanthan-based hydrogels.
abstract: Xanthan has been reticulated with epichlorohydrin to obtain a hydrogel for use in drug retardation. The obtained gel shows swelling degrees up to 1000. Theophylline has been inserted by diffusion into this gel; concentrations around 150 mg theophylline/g dry hydrogel being obtained. Controlled release of theophylline has been established by elution in a close recirculation system. Zero-order kinetics has been obtained in the diffusion process of theophylline into the eluent, within a 14 h time interval.
authors.affiliation: Polytechnic Institute of Jassy, Romania.
authors.forename: S
authors.initials: S
authors.lastname: Dumitriu
authors.forename: M
authors.initials: M
authors.lastname: Dumitriu
mesh_terms: D004337:Drug Carriers; D016503:Drug Delivery Systems; D005782:Gels; D007700:Kinetics; D011135:Polysaccharides, Bacterial; D013806:Theophylline / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D005782:Gels; D011135:Polysaccharides, Bacterial; D013806:Theophylline; C002563:xanthan gum