title: Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells.
abstract: Perforin and granzymes are considered to be instrumental in cell-mediated cytolysis by cytotoxic T cells and natural killer cells. Here, Gillian Griffiths and Christoph Mueller describe the expression of perforin and granzymes, emphasizing studies in vivo, and discuss the possibility that these proteins are useful diagnostic markers for immune responses involving cytolytic cells.
authors.affiliation: Basel Institute for Immunology, Switzerland.
authors.forename: G M
authors.initials: GM
authors.lastname: Griffiths
authors.forename: C
authors.initials: C
authors.lastname: Mueller
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000175:diagnosis; D015415:Biomarkers; D003602:Cytotoxicity, Immunologic; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000276:immunology*; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D012697:Serine Endopeptidases / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic; D014181:Transplantation Immunology; D014777:Virus Diseases / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin; D012697:Serine Endopeptidases