Benign parotid oncocytoma with the chromosomal abnormality trisomy 7.
This report concerns the first cytogenetical study of a benign salivary gland oncocytoma. The cultured tumor was studied in five consecutive preparations. The first three were dominated by cells with a normal karyotype. In the two subsequent preparations a hyperdiploid stemline characterized by trisomy 7 had taken over. Trisomy 7 has previously been observed in a number of different, benign, premalignant and malignant conditions. We interpreted trisomy 7 in the salivary gland oncocytoma, as in these other conditions, to be a neoplasia-related, probably primary, gross chromosomal change and not an expression of aging or comparable events in normal cells.
Mark
J
J
Department of Pathology and Cytogenetics, Central Hospital, Skövde, Sweden.
Dahlenfors
R
R
Havel
G
G
Böckmann
P
P
D000236:Adenoma / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007621:Karyotyping; D008297:Male; D010307:Parotid Neoplasms / Q000235:genetics*; D014314:Trisomy