Antiphospholipid antibodies in migraine.
We studied the presence of serum antiphospholipid antibodies (APA) in 35 patients with migraine and 75 controls. None of the controls showed APA, while we found these antibodies in five patients out of the 35 studied (p = 0.003). The clinical features of migraineurs with APA were similar to those of patients without them. After a follow-up of one to two years, no patient suffered any neurological complications or developed any clinical features that would suggest the presence of autoimmune disease. Our results suggest that APA are not prominent in the pathogenesis of migraine attacks, or significant in the course of otherwise healthy migraine patients.
Iñiguez
C
C
Servicio de Neurologia, Hospital Ramón y Cajal, Madrid, Spain.
Pascual
C
C
Pardo
A
A
Martinez-Castrillo
J C
JC
Alvarez-Cermeño
J C
JC
D000328:Adult; D002308:Cardiolipins / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008297:Male; D008881:Migraine Disorders / Q000276:immunology*; D010743:Phospholipids / Q000276:immunology*; D011446:Prospective Studies
D002308:Cardiolipins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010743:Phospholipids