title: Activation of blood coagulation and fibrinolysis in Graves' disease.
abstract: We studied blood coagulation and fibrinolysis activities in hyperthyroidism before and after methimazole or 131I. Fibrinopeptide A and B beta 15-42, in vivo indicators of thrombin and plasmin activity, were measured by RIA, while fibrinogen by the Clauss method. We studied 50 patients, affected by toxic diffuse goiter. We evaluated 21 of them before and after treatment. Fibrinogen, fibrinopeptide A, and B beta 15-42 were higher in patients than in controls (p less than 0.0001). There was no difference in fibrinopeptide A nor in B beta 15-42 before or after treatment. In euthyroidism fibrinogen returned to normal values. Inflammation of the thyroid gland secondary to autoimmunity may activate blood coagulation by release of tissue factor. High fibrinogen before treatment may be explained as an aspecific response. Since it persists in euthyroidism, autoimmunity could account for high fibrinopeptide A and B beta 15-42 aftertreatment.
authors.affiliation: Institute of Internal Medicine, University of Cagliari, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Marongiu
authors.forename: M
authors.initials: M
authors.lastname: Conti
authors.forename: M L
authors.initials: ML
authors.lastname: Murtas
authors.forename: G
authors.initials: G
authors.lastname: Mameli
authors.forename: G G
authors.initials: GG
authors.lastname: Sorano
authors.forename: E
authors.initials: E
authors.lastname: Martino
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D005344:Fibrinopeptide A / Q000378:metabolism; D005345:Fibrinopeptide B / Q000378:metabolism; D006111:Graves Disease / Q000097:blood* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D007457:Iodine Radioisotopes; D010446:Peptide Fragments; C033786:fibrinogen Bbeta (15-42); D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D008713:Methimazole; D005340:Fibrinogen