Percutaneous absorption and metabolism of aldrin by rat skin in diffusion cells.
Using a static diffusion cell with varying receptor fluids the viability of isolated rat skin mounted as whole skin or as split thickness skin has been studied. Skin viability decreased with time with phosphate buffer or Eagles MEM and was not supported with ethanol/water as the receptor fluid. The pesticide aldrin was absorbed through the skin into ethanol/water but not the aqueous receptor fluids. With viable skin preparations aldrin was metabolised to dieldrin and absorbed aldrin and the metabolite remained in the skin. Viable skin preparations must be used to assess in vitro, the degree of metabolism of xenobiotics which occurs during percutaneous absorption.
Macpherson
S E
SE
Wolfson Unit of Clinical Pharmacology, Medical School, University of Newcastle upon Tyne, UK.
Scott
R C
RC
Williams
F M
FM
D000452:Aldrin / Q000493:pharmacokinetics*; D000818:Animals; D002470:Cell Survival; D004026:Dieldrin / Q000378:metabolism; D015194:Diffusion Chambers, Culture; D008297:Male; D009245:NADH Dehydrogenase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012869:Skin Absorption
D009245:NADH Dehydrogenase; D004026:Dieldrin; D000452:Aldrin