Effects of single and long-term droperidol administration on open-field and stereotyped behavior of rats.
The effects of single and long-term droperidol administration on rat open-field and apomorphine-induced stereotyped behavior were studied. A single dose of droperidol decreased dose dependently not only locomotion and rearing frequencies in the open-field but also the apomorphine effects. Long-term droperidol administration induced significant tolerance to all parameters of activity recorded in the open-field. Unlike other dopamine blockers, droperidol withdrawn from long-term droperidol administration wasn't able to increase rats' open-field parameters significantly. However, like other dopamine blockers, droperidol withdrawn produced an augmented responsiveness to apomorphine-induced stereotyped behavior. These results suggest that the supersensitivity of central dopamine receptors developed after droperidol treatment may have peculiar characteristics.
Frussa-Filho
R
R
Department of Pharmacology, Escola Paulista de Medicina, Marília, São Paulo, Brazil.
Palermo-Neto
J
J
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001143:Arousal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D004329:Droperidol / Q000494:pharmacology*; D008134:Long-Term Care; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009048:Motor Skills / Q000187:drug effects; D009434:Neural Pathways / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D012931:Social Environment; D013239:Stereotyped Behavior / Q000187:drug effects*
D011954:Receptors, Dopamine; D001058:Apomorphine; D004329:Droperidol