[Effectiveness of dioxidine in a model of Staphylococcal necrotic-suppurative encephalomeningitis (according to electron microscopy data].
Dioxidine efficacy was studied on a model of staphylococcal necrotic suppurative encephalomeningitis. There was a relationship of the development of disease signs to the value of the contaminating dose. Dioxidine was shown to have a therapeutic effect. Purulent inflammation in the brain either undevelop or was more limited. Examination of the changes in the ultrastructure of the nervous tissue also confirmed the efficacy of dioxidine. The treated mice had single inflammation infiltrations in the presence of the intact structure of the nervous tissue, the cell composition of the infiltrations changing in the direction of predominance of the mononuclear phagocytes. The phagocytes were in the state of hyperactivity and phagocytosis was of the completed nature. Secondary phagocytosis of the phagocytes and cell detritus was recorded.
Stebaeva
L F
LF
Padeĭskaia
E N
EN
Shipilova
L D
LD
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D008590:Meningoencephalitis / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008854:Microscopy, Electron; D009336:Necrosis; D010586:Phagocytes / Q000187:drug effects; D011810:Quinoxalines / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000473:pathology
D000890:Anti-Infective Agents; D011810:Quinoxalines; C001077:dioxidine
Effektivnost' dioksidina na modeli stafilokokkovogo nekroticheski-gnoĭnogo éntsefalomeningita (po dannym élektronnoĭ mikroscopii).