title: Current issues in evaluating the efficacy of oral poliovirus vaccine and inactivated poliovirus vaccine immunization.
abstract: Although epidemic poliomyelitis in the United States has been eliminated, there are a number of current issues that concern the use of oral attenuated poliovirus vaccine in comparison with the new enhanced-potency inactivated vaccine. Although wild-type poliovirus is almost eradicated in developed nations, vaccine-induced polio exists, at a low but persistent rate. This article reviews the current issues and suggests a return to the Institute of Medicine's 1988 recommendations concerning combined immunization with inactivated poliovirus vaccine and oral poliovirus vaccine.
authors.affiliation: Pasteur Mérieux, Marnes-La-Coquette, France.
authors.forename: S A
authors.initials: SA
authors.lastname: Plotkin
mesh_terms: D006801:Humans; D011051:Poliomyelitis / Q000517:prevention & control*; D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral
chemical_list: D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral