Complete Freund adjuvant treatment of pregnant females influences resorption rates in CBA/J x DBA/2 matings via progesterone-mediated immunomodulation.
Treatment of pregnant CBA/J females with CFA at day 0.5 and 7.5 of pregnancy significantly reduced the fetal resorption rates from 45% to 29% (P less than 0.05). Supernatants of progesterone-treated spleen cells from CFA treated CBA/J females pregnant of DBA/2 males significantly reduced natural cytotoxicity, while those of untreated identically pregnant mice had no effect. Supernatants of CFA-treated virgin mice blocked natural cytotoxicity to the same extent as those of CFA-treated pregnant mice. These data suggest that nonspecific immunostimulation induces progesterone receptors in spleen cells of CBA mice and that these receptors allow a progesterone dependent suppressive pathway to exert an antiresorptive effect.
Szekeres-Bartho
J
J
Institute of Microbiology, University Medical School, Pecs, Hungary.
Kinsky
R
R
Kapovic
M
M
Chaouat
G
G
D000818:Animals; D005260:Female; D005327:Fetal Resorption / Q000276:immunology / Q000517:prevention & control*; D005620:Freund's Adjuvant / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology / Q000502:physiology*; D011980:Receptors, Progesterone / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000502:physiology
D011980:Receptors, Progesterone; D011374:Progesterone; D005620:Freund's Adjuvant