title: [Study on porphyrins:synthesis and antitumor activity of porphyrin-fluorouracil compounds].
abstract: Three covalently linked porphyrin-fluorouracil compounds were synthesized. Measurement using these compounds for inhibition of mice transplanted tumor growth, cytotoxicity to mice cancer cells and the mice ear index under exposure to a light was performed. The results indicated that all these compounds were phototoxic to the cancer cells, and compound 1 was the most effective among them.
authors.affiliation: Department of Chemistry, Wuhan University.
authors.forename: S Q
authors.initials: SQ
authors.lastname: Huang
authors.forename: Z C
authors.initials: ZC
authors.lastname: Jiang
authors.forename: L Z
authors.initials: LZ
authors.lastname: Li
authors.forename: J Y
authors.initials: JY
authors.lastname: Xu
authors.forename: J
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D010778:Photochemotherapy; D011166:Porphyrins / Q000138:chemical synthesis* / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C072996:5,10,15-triphenyl-(20-(5-fluorouracil)acetylamino)phenylporphyrin