Hypoxanthine depletion induced by xanthine oxidase inhibits malaria parasite growth in vitro.
Berman
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PA
Department of Chemical Pathology, University of Cape Town Medical School Observatory, South Africa.
Human
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L
D000225:Adenine / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D002374:Catalase / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D011687:Purines / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000494:pharmacology; D014969:Xanthine Oxidase / Q000494:pharmacology*
D002250:Carbon Radioisotopes; D007042:Hypoxanthines; D011687:Purines; D019271:Hypoxanthine; D002738:Chloroquine; D000255:Adenosine Triphosphate; D002374:Catalase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D000225:Adenine; D005998:Glycine