title: [Impaired fibrinolytic response to the venous occlusion test in patients with cryptogenic colitis].
abstract: The fibrinolytic response to venous occlusion was studied in 17 patients with inflammatory bowel disease: 7 with Crohn's disease, 10 with ulcerative colitis and compared with those obtained in 20 controls. Patients with inflammatory bowel disease showed decreased tissue-type plasminogen activator antigen release (t-PA Ag), no significant Von Willebrand antigen release (vWF Ag), and a residual plasminogen activator inhibitor activity (PAI activity) after venous occlusion. These modifications were more important in the evolutive colitis group compared with the remission group. Hypofibrinolysis, as defined by a defective t-PA release, and a residual PAI activity after venous occlusion might contribute to digestive and/or extra digestive thrombotic manifestations observed during the course of inflammatory bowel diseases.
authors.affiliation: Laboratoire d'Hématologie et Immunologie, CHRU, Nîmes.
authors.forename: J C
authors.initials: JC
authors.lastname: Gris
authors.forename: J F
authors.initials: JF
authors.lastname: Schved
authors.forename: C
authors.initials: C
authors.lastname: Raffanel
authors.forename: A
authors.initials: A
authors.lastname: Dubois
authors.forename: D
authors.initials: D
authors.lastname: Ribard
authors.forename: J L
authors.initials: JL
authors.lastname: Balmes
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000503:physiopathology*; D003424:Crohn Disease / Q000503:physiopathology*; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D010960:Plasminogen Activators / Q000032:analysis; D015849:Plasminogen Inactivators / Q000032:analysis; D012016:Reference Values; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D015849:Plasminogen Inactivators; D014841:von Willebrand Factor; D010960:Plasminogen Activators
vernacular_title: Réponse anormale au test d'occlusion veineuse chez les patients atteints de colite cryptogénique.