Molecular recognition: models for drug design.
The review takes examples, mostly from the recent literature, to illustrate how an understanding of physico-chemical properties and an appreciation of the molecular shape and electronic properties can lead to a better insight into molecular recognition processes. The techniques used to generate 3-dimensional structures of molecules and the influence this information has had on the drug design cycle, are briefly discussed.
Breckenridge
R J
RJ
Drug Design Group, Sandoz Pharma Ltd., Basel, Switzerland.
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003461:Crystallography; D015195:Drug Design; D010450:Endopeptidases / Q000737:chemistry; D005493:Folic Acid Antagonists; D006801:Humans; D006860:Hydrogen Bonding; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry; D014961:X-Ray Diffraction
D005493:Folic Acid Antagonists; D046911:Macromolecular Substances; D010456:Peptides, Cyclic; D010450:Endopeptidases