title: Intraarterial perfusion of prostaglandin E1 after lumbar sympathectomy or reconstruction on femoropopliteal segment.
abstract: Out of 100 patients treated by intraarterial perfusion of prostaglandin E1 we selected 36 cases who have been treated after a lumbar sympathectomy or reconstruction on the femoro-popliteal segment. The patients were in the III and IV stage of occlusive diseases by Fontain. All patients were divided into four groups: (a) prostaglandin E1 after a lumbar sympathectomy (20); (b) prostaglandin E1 after failed femoro-popliteal bypass (8); (c) prostaglandin E1 with patent femoro-popliteal bypass and distal progression of the occlusive disease (3); (d) prostaglandin E1 with previously femoro-popliteal reconstruction and poor run off (5). After intraoperative introduction of a catheter into the superficial femoral artery, profunda femoral artery (a, b), a patent graft (c) or just implanted graft (d), a continuous intraarterial perfusion of prostaglandin E1 was applied, in doses 10 nanograms/kg body weight/minute, in total doses 3000 nanograms. The perfusion time was 48-72 h. The patients were controlled immediately after treatment as well as 1, 3, 6 and 12 months after. Our early and late results of the intraarterial perfusion of prostaglandin E1 proved as a very successful limb salvage procedure.
authors.affiliation: Institute for Cardiovascular Diseases, UCC, Belgrade, Yugoslavia.
authors.forename: L B
authors.initials: LB
authors.lastname: Davidovic
authors.forename: M R
authors.initials: MR
authors.lastname: Vranes
authors.forename: S I
authors.initials: SI
authors.lastname: Lotina
authors.forename: I F
authors.initials: IF
authors.lastname: Cernak
authors.forename: D B
authors.initials: DB
authors.lastname: Velimirovic
authors.forename: P L
authors.initials: PL
authors.lastname: Stojanov
authors.forename: R P
authors.initials: RP
authors.lastname: Sindjelic
authors.forename: D Z
authors.initials: DZ
authors.lastname: Sagic
authors.forename: I S
authors.initials: IS
authors.lastname: Cinara
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use*; D001157:Arterial Occlusive Diseases / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007866:Leg / Q000098:blood supply*; D008161:Lumbosacral Region; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery / Q000601:surgery*; D011182:Postoperative Care; D016879:Salvage Therapy; D013562:Sympathectomy
chemical_list: D000527:Alprostadil