Staphylococcal lipoteichoic acid exerts growth factor-like activity towards human and murine cells.
Lipoteichoic acid (LTA) was extracted from Staphylococcus saprophyticus strain S1 and tested for the capacity to induce hematopoietic and lymphatic cell proliferation. As compared to nontreated cells, the number of human bone marrow cells significantly increased in the presence of low LTA concentrations. Optimal growth was observed on the fifth day of in vitro incubation. After exposure to LTA, the lymphocyte proliferation rate also increased in a dose and time dependent manner. On the other hand, human epithelial cells and fibroblasts did not show enhanced growth activities in the presence of LTA.
Ohshima
Y
Y
St. Marianna University, Department of Microbiology, School of Medicine, Kawasaki, Japan.
Beuth
J
J
Ko
H L
HL
Roszkowski
W
W
Pulverer
G
G
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D008070:Lipopolysaccharides; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D013210:Staphylococcus; D013682:Teichoic Acids / Q000494:pharmacology*
D003115:Colony-Stimulating Factors; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid