title: Systolic intra-cavitary gradients following aortic valve replacement: an echo-Doppler study.
abstract: Systolic left ventricular flow was studied by pulsed and continuous wave Doppler in 41 patients following aortic valve replacement for severe stenosis (mean valvular area: 0.58 cm2; range 0.3-0.75 cm2). Maximal left ventricular velocities by continuous wave Doppler study, were higher than 2.5 m.s-1 with a sharp peak at end-systole in five patients in basal condition and in four others after amyl nitrite inhalation. Pulsed Doppler study showed that the high velocities started from the apex or mitral papillary muscle level with a marked chamber narrowing at two-dimensional echography. Only one patient had a systolic anterior motion (SAM) of the anterior mitral leaflet with mitral-septal contact. The left ventricular dimensions, as measured by M-mode echography were compared in the various patient groups. High velocities seemed statistically associated with the smaller systolic and diastolic diameters of the left ventricle and outflow tract and the larger relative thickness of the posterior wall. The highest pressure gradients disappeared after correction of hypovolaemia (one patient), clearance of pericardial effusion (one patient), or beta-blocker treatment (three patients). The present study confirms that left intra-ventricular dynamic gradients can occur after clearance of fixed outflow obstruction, for which Doppler examination is a reliable and innocuous diagnostic means. Haemodynamically, this syndrome resembles hypertrophic obstructive cardiomyopathy, but the scarcity of the systolic anterior motion of the mitral leaflets is suggestive of a different mechanism that could be cavity obliteration or mid-ventricular obstruction.
authors.affiliation: Division of Cardiology B, Hôtel-Dieu, C.H.U. Rennes, France.
authors.forename: M
authors.initials: M
authors.lastname: Laurent
authors.forename: O
authors.initials: O
authors.lastname: Leborgne
authors.forename: C
authors.initials: C
authors.lastname: Clement
authors.forename: J L
authors.initials: JL
authors.lastname: Foulgoc
authors.forename: A
authors.initials: A
authors.lastname: Le Helloco
authors.forename: C
authors.initials: C
authors.lastname: Almange
authors.forename: P
authors.initials: P
authors.lastname: Leborgne
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000503:physiopathology / Q000601:surgery*; D001783:Blood Flow Velocity / Q000187:drug effects; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006350:Heart Valve Prosthesis; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000494:pharmacology; D005996:Nitroglycerin / Q000494:pharmacology; D000439:Pentanols / Q000494:pharmacology; D011312:Pressure; D013318:Stroke Volume; D013599:Systole / Q000502:physiology; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology*
chemical_list: D009566:Nitrates; D000439:Pentanols; D005996:Nitroglycerin; C036285:amyl nitrate