Effect of long-term n-butanol ingestion on rat brain polypeptide synthesis directed by endogenous messengers.
Long-term ingestion of sublethal n-butanol doses by rats led to a noteworthy increase in the resistance of in vitro brain ribosomal function to the acute inhibitory action of ethanol and isopropanol. Withdrawal of n-butanol did not change this adaptation process immediately. The step affected seems to be the elongation of polypeptide chains. The dependence of in vitro translation on incubation temperature was affected by the adaptation process, the translation system of chronic animals being less stimulatable than that of control animals at low temperature.
Muñoz
R
R
Departamento de Bioquímica, Biología Molecular y Fisiología, Facultad de Ciencias, Universidad de Valladolid, Spain.
Iglesias
R
R
Ferreras
J M
JM
Arias
F J
FJ
Rojo
M A
MA
Girbés
T
T
D000433:1-Propanol / Q000494:pharmacology; D000222:Adaptation, Physiological; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D000440:Butanols / Q000494:pharmacology*; D002474:Cell-Free System; D004351:Drug Resistance; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D010452:Peptide Biosynthesis; D010441:Peptide Chain Elongation, Translational / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000440:Butanols; D000431:Ethanol; D000433:1-Propanol