title: [Alterations of the hypophyseal-gonadal axis in chronic renal insufficiency and after renal transplantation].
abstract: The purpose of this study is to assess hormonal disorders of the hypophysis-gonad axis in 92 patients with chronic renal failure undergoing hemodialysis and in 14 patients after renal transplantation; concentrations of testosterone, free testosterone, estradiol, progesterone, gonadotropins and prolactin are analyzed. We have tried to establish typical alteration patterns, and to this effect, we have analyzed the results according to the etiology of chronic renal failure and to the impact of several dialysis factors on the hormones assessed. A typical patterns of hormonal disorder in the hypophysis-gonad axis has not been observed, nor a disorder that may be typical of a given etiology. Hyperprolactinemia affects men and women in equal proportion. No impact of dialysis factors on hormonal disorders has been observed. After renal transplantation, hormonal disorders disappear and normality of hypophysis-gonad axis is restored.
authors.affiliation: Laboratorio de Radioinmunoanálisis, Clínica Nervión, Madrid.
authors.forename: J
authors.initials: J
authors.lastname: Chisvert León
authors.forename: F
authors.initials: F
authors.lastname: Valderrábano Quintana
mesh_terms: D000328:Adult; D005260:Female; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis*; D006065:Gonadotropins, Pituitary / Q000096:biosynthesis*; D006066:Gonads / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000378:metabolism*
chemical_list: D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary
vernacular_title: Alteraciones del eje hipofisario-gonadal en la insuficiencia renal crónica y después del trasplante renal.