[Effects of high-dose fentanyl on intraductal pressure in the choledochoduodenal junction in dogs].
Changes in intraductal pressure in choledochoduodenal junction were studied following intravenous administration of fentanyl in dogs. The intraductal pressure was measured with constant-rate infusion method. A statistically significant increase in the intraductal pressure was demonstrated after the intravenous administration of fentanyl 5 micrograms.kg-1 and 75 micrograms.kg-1. The increase in intraductal pressure following fentanyl administration at a dose of 75 micrograms.kg-1 persisted for more than 5 hours. We conclude that in case of intravenous high-dose fentanyl administration special attention should be paid to spasm of choledochoduodenal sphincter.
Miyamoto
M
M
Department of Anesthesiology, Sapporo Medical College & Hospital.
Iwasaki
H
H
Omote
T
T
Namiki
A
A
D000818:Animals; D003135:Common Bile Duct / Q000502:physiology*; D004285:Dogs; D004386:Duodenum / Q000502:physiology*; D005283:Fentanyl / Q000008:administration & dosage*; D007275:Injections, Intravenous; D011312:Pressure
D005283:Fentanyl