Activation of immediate early genes after acute stress.
We used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and in the CA1 region of the hippocampus. This regionally-specific response suggests that IEGs may have a role in the mediation of acute stress responses in the central nervous system.
Schreiber
S S
SS
Department of Neurology, University of Southern California, School of Medicine, Los Angeles 90033.
Tocco
G
G
Shors
T J
TJ
Thompson
R F
RF
D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics; D051766:Early Growth Response Protein 1; D004597:Electroshock; D005786:Gene Expression Regulation; D017874:Immediate-Early Proteins; D008297:Male; D009693:Nucleic Acid Hybridization; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000209:etiology / Q000235:genetics*; D013623:Tail; D014157:Transcription Factors / Q000235:genetics
D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; D017874:Immediate-Early Proteins; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D014157:Transcription Factors