[The effect of specific transfusion therapy on the level of circulating immune complexes in hemophilia patients].
The level of circulating immune complexes (CIC) was measured in 108 hemophilic patients registered at the Republican Center for Hemophilia Treatment. High levels of CIC were detected in hemophilic patients of different age. The concentrations of CIC were higher in adult patients than in children. Formation of immune complexes in the test groups did not go beyond the framework of the physiological process, for the signs of vasculitis, which is an indispensable component of immunocomplex pathology, could not be identified. Higher levels of CIC in adults were related to a greater number of transfusions made throughout the life, particularly if the annual dose of the preparations infused exceeded 10,000 Units of factor VIII or IX. No significant correlation was established between the rise of CIC levels in the patients' serum and the biochemical alterations in liver function, detected in these patients. Therefore, CIC detected by the authors are not specific and lesions of the liver parenchyma in hemophilic patients are not determined by their presence.
Andreeva
T A
TA
Fedorova
Z D
ZD
Khanin
T M
TM
Klimova
N I
NI
D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D001803:Blood Transfusion / Q000379:methods; D002648:Child; D002675:Child, Preschool; D006467:Hemophilia A / Q000276:immunology / Q000628:therapy*; D002836:Hemophilia B / Q000276:immunology / Q000628:therapy*; D006509:Hepatitis B / Q000276:immunology; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014181:Transplantation Immunology
D000936:Antigen-Antibody Complex
Vliianie transfuzionnoĭ spetsificheskoĭ terapii na uroven' tsirkuliruiushchikh immunnykh kompleksov u bol'nykh gemofilieĭ.