[Decrease in the intensity of luminol-dependent chemiluminescence of neutrophils in patients with pulmonary tuberculosis].
The ability of neutrophils to generate free oxygen forms, and the activity of glutathione-conjugated enzymes and superoxide dismutase were investigated in 94 patients with pulmonary tuberculosis. A drop in the oxygen-generating ability of the patients' neutrophils was revealed. The interrelation between the decrease of activity of antioxidative enzymes and the drop in the oxygen-generating ability of neutrophils are shown. Clinical and pathophysiological importance of the changes revealed is discussed.
Muminov
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TA
D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D008165:Luminol / Q000494:pharmacology; D008954:Models, Biological; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000097:blood; D014397:Tuberculosis, Pulmonary / Q000097:blood*
D008165:Luminol; D005954:Glucosephosphate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase
Snizhenie intensivnosti liuminolzavisimoĭ khemiliuminestsentsii neĭtrofilov u bol'nykh tuberkulezom legkikh.