title: Vacuolar myositis with expression of both MHC class I and class II antigens on skeletal muscle fibers.
abstract: We describe here a 10-year-old patient with high levels of serum IgE and inflammatory myopathy whose muscle fibers exhibit excessive autophagy. Previous studies have demonstrated surface expression of class I MHC antigens on muscle fibers from patients with inflammatory myopathy. The muscle fibers of this patients showed marked expression of both class I and class II MHC antigens. The reaction products were demonstrated not only on sarcolemma but also in and around some vacuoles. Both CD4-positive and CD8-positive T-lymphocytes were noted in inflammatory exudates surrounding these fibers but B-lymphocytes were rare. We hypothesize that myocyte expression of both class I and class II antigens may play a role in the pathogenesis of this new type of inflammatory myopathy.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Higuchi
authors.forename: M
authors.initials: M
authors.lastname: Nerenberg
authors.forename: T
authors.initials: T
authors.lastname: Ijichi
authors.forename: H
authors.initials: H
authors.lastname: Fukunaga
authors.forename: K
authors.initials: K
authors.lastname: Arimura
authors.forename: F
authors.initials: F
authors.lastname: Usuki
authors.forename: M
authors.initials: M
authors.lastname: Kuriyama
authors.forename: M
authors.initials: M
authors.lastname: Osame
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D002648:Child; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007181:Inclusion Bodies, Viral; D008297:Male; D009132:Muscles / Q000276:immunology* / Q000473:pathology; D009220:Myositis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D010587:Phagocytosis; D011239:Prednisolone / Q000627:therapeutic use; D014617:Vacuoles
chemical_list: D006680:HLA Antigens; D006684:HLA-DR Antigens; D007073:Immunoglobulin E; D011239:Prednisolone