title: [Digestive manifestations of common variable immunodeficiency].
abstract: We present 4 cases of common variable immunodeficiency with main digestive clinical manifestations. In all four cases chronic diarrhea with intestinal malabsorption predominated, as well as the presence lymphoid nodular hyperplasia; in one case Giardia infestation could be identified; one patient also presented chronic pancreatitis, or recurrent aphthous stomatitis and active chronic hepatitis; sideroblastic anemia could be observed in another patient. All patients had favorable evolution during follow-up which lasted at least 14 months in substitutive treatment with immunoglobulins. One of our patients presented an elevated number of suppressor T lymphocytes, with inversion of the T helper/T suppressor ratio which improved with cimetidine treatment.
authors.affiliation: Servicio de Medicina Interna III, Hospital Clínico de San Carlos, Universidad Complutense, Madrid.
authors.forename: V
authors.initials: V
authors.lastname: Estrada Pérez
authors.forename: J
authors.initials: J
authors.lastname: Pérez de la Serna
authors.forename: J
authors.initials: J
authors.lastname: García Paredes
authors.forename: M
authors.initials: M
authors.lastname: Cortés León
authors.forename: F M
authors.initials: FM
authors.lastname: Gutiérrez Marcos
authors.forename: R V
authors.initials: RV
authors.lastname: Estrada Sáiz
mesh_terms: D000328:Adult; D004066:Digestive System Diseases / Q000209:etiology*; D005260:Female; D005873:Giardiasis / Q000209:etiology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008206:Lymphatic Diseases / Q000209:etiology; D008286:Malabsorption Syndromes / Q000209:etiology; D008297:Male
vernacular_title: Manifestaciones digestivas de la inmunodeficiencia común variable.