4-(4-R-phenylamino)-5-methoxy-1,2-benzoquinones are new selective inhibitors of carbon tetrachloride-initiated free radical reactions in liver.
The action of several 1,2-benzoquinone derivatives on free radical processes initiated by carbon tetrachloride was studied. Among them a substance that effectively inhibited lipid peroxidation without substantial influence on covalent binding of radical products of metabolic cleavage of carbon tetrachloride as well a substance that equally inhibited both processes were found. It was shown that 1,2-benzoquinones can be useful tool for investigation of free radical mechanisms of carbon tetrachloride-initiated liver cell damage in vivo.
Kostyuk
V A
VA
Department of Biology, V.I. Lenin Byelorussian State University, Minsk, USSR.
Potapovich
A I
AI
Tereshchenko
S M
SM
D000818:Animals; D016227:Benzoquinones / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D016227:Benzoquinones; D005609:Free Radicals; D009249:NADP; D002251:Carbon Tetrachloride