title: Use of nonimaging nuclear medicine techniques to assess the effect of flunixin meglumine on effective renal plasma flow and effective renal blood flow in healthy horses.
abstract: The effect of flunixin meglumine on renal function was studied in 6 healthy horses by use of nonimaging nuclear medicine techniques. Effective renal plasma flow (ERPF) and effective renal blood flow (ERBF) were determined by plasma clearance of 131I-orthoiodohippuric acid before and after administration of flunixin meglumine. Mean ERPF and ERBF was 6.03 ml/min/kg and 10.7 ml/min/kg, respectively, before treatment and was 5.7 ml/min/kg and 9.7 ml/min/kg, respectively, after treatment. Although ERPF and ERBF decreased after flunixin meglumine administration, the difference was not statistically significant.
authors.affiliation: Department of Rural Practice, College of Vetertinary Medicine, University of Tennessee, Knoxville 37901-1071.
authors.forename: J P
authors.initials: JP
authors.lastname: Held
authors.forename: G B
authors.initials: GB
authors.lastname: Daniel
mesh_terms: D000818:Animals; D003002:Clonixin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006736:Horses / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D009683:Nuclear Medicine / Q000379:methods; D012044:Regression Analysis; D012079:Renal Circulation / Q000187:drug effects*
chemical_list: C014558:flunixin meglumine; D003002:Clonixin