Plasticity of neuroendocrine-immune interactions during aging.
Intact neuroendocrine-immune interactions are essential for the development and functional maintenance of both systems. Normal physiological aging appears to be, in part, dependent on age-related modifications of neuroendocrine-immune interactions. The thymus plays a major role in this context. Experimental manipulation at the thymic or neuroendocrine level may reciprocally correct the age-associated dysfunctions, suggesting the reversible nature of such phenomena.
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Immunology Center, Research Dept. Inrca, Ancona, Italy.
D000222:Adaptation, Physiological; D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000375:Aging / Q000276:immunology / Q000502:physiology*; D000818:Animals; D006801:Humans; D007121:Immunocompetence / Q000502:physiology; D051379:Mice; D015213:Neuroimmunomodulation / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology*; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology / Q000637:transplantation
D000276:Adjuvants, Immunologic