[Synthesis of analogues of carbocyclic nucleoside].
The derivatives of 5'-dehydroxymethyl carbocyclic nucleoside were synthesized by condensation of cyclopentenyl chloride and corresponding pyrimidines followed by epoxidation and substitution. All compounds were screened for anticancer and antiviral activities and no activity was found.
Qiao
L
L
School of Pharmaceutical Sciences, Beijing Medical University.
Ma
L T
LT
Min
J M
JM
Zhang
L H
LH
D000818:Animals; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D006515:Hepatitis B virus / Q000187:drug effects; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D009705:Nucleosides