Decrease of frontal metabolism demonstrated by positron emission tomography in a population of healthy elderly volunteers.
Frontal metabolism measured with positron emission tomography is shown to be decreased relatively to that in other cortical or sub-cortical areas, in a population of healthy elderly compared to young volunteers. Cortical atrophy or neuronal depopulation are unlikely to entirely explain this physiological phenomenon, and sub-cortico-cortical deactivation should play a role, analogous to that proposed in subcortical diseases.
Salmon
E
E
Department of Neurology, University of Liège, Belgium.
Maquet
P
P
Sadzot
B
B
Degueldre
C
C
Lemaire
C
C
Franck
G
G
D000368:Aged; D000375:Aging / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D003847:Deoxyglucose / Q000031:analogs & derivatives; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D014055:Tomography, Emission-Computed
D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose