Lethal chromosomal deletions in the mouse, a model system for the study of development and regulation of postnatal gene expression.
Mechanisms involved in the regulation of development and its genetic control are receiving ever-increasing attention in studies of mammalian developmental genetics. The potential success of such studies is strongly enhanced by the availability of suitable systems of analysis. Such a system was identified in a series of radiation-induced chromosomal deletions at and around the albino (c) locus of the mouse associated with cell type-specific effects on liver differentiation. Their detailed study has aided the analysis of possible mechanisms of cell type-specific gene expression. As summarized in this review, the experimental results strongly suggest that specific trans-acting developmental regulatory genes are concerned with the differentiation of hormone-inducible expression of a cluster of hepatocyte specific structural genes mapping in different parts of the genome.
Gluecksohn-Waelsch
S
S
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461.
DeFranco
D
D
D000375:Aging; D000417:Albinism / Q000235:genetics; D000818:Animals; D002872:Chromosome Deletion; D005333:Fetus; D005786:Gene Expression Regulation; D005804:Genes, Lethal; D008099:Liver / Q000196:embryology / Q000254:growth & development / Q000502:physiology; D051379:Mice