title: [Pharmacokinetic comparison of intraperitoneal and intravenous 5-Fu administration].
abstract: Pharmacokinetic comparison of 5-Fluorouracil (5-Fu) administered ip versus iv was made in rabbits. Ip administration of bolus and large volume of 5-Fu could maintain high, stable and sustained concentration in the peritoneal cavity, portal vain and liver while sparing the systemic circulation. After iv bolus administration of 5-Fu, drug concentration in the systemic circulation was very high. Although iv administration of 5-Fu could lead to high concentration in the portal vein and liver, sustainment of concentration was relatively of short duration and the 5-Fu concentration was very low in the peritoneal fluid. The authors believe that ip chemotherapy has a significant pharmacokinetic advantage over the conventional iv route in preventing and treating recurrences in the peritoneal cavity and liver metastasis after surgery for gastro-intestinal malignancies.
authors.affiliation: Rui Jin Hospital, Shanghai Second Medical University.
authors.forename: S H
authors.initials: SH
authors.lastname: Qing
mesh_terms: D000818:Animals; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits; D014018:Tissue Distribution
chemical_list: D005472:Fluorouracil