title: L-tryptophan-induced eosinophilia-myalgia syndrome. I. Report of two cases with pseudoxanthoma-elasticum-like skin changes.
abstract: Two female patients who fulfilled the criteria for L-tryptophan-induced eosinophilia-myalgia syndrome (EMS) had, together with morphea-like and fasciitis-like sclerotic changes of the skin, lesions that clinically mimicked pseudoxanthoma elasticum (PXE). Histology was compatible with the diagnosis; electron microscopy did not reveal calcium deposits. PXE-like changes may represent an additional feature of the pleomorphic L-tryptophan-induced EMS.
authors.affiliation: Department of Dermatology, Hôpital Cantonal Universitaire, Geneva, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Mainetti
authors.forename: E
authors.initials: E
authors.lastname: Schmied
authors.forename: I
authors.initials: I
authors.lastname: Masouyé
authors.forename: P
authors.initials: P
authors.lastname: Chavaz
authors.forename: J H
authors.initials: JH
authors.lastname: Saurat
mesh_terms: D016603:Eosinophilia-Myalgia Syndrome / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011561:Pseudoxanthoma Elasticum / Q000139:chemically induced / Q000473:pathology*; D012594:Scleroderma, Localized / Q000139:chemically induced / Q000473:pathology; D012867:Skin / Q000473:pathology; D014364:Tryptophan / Q000009:adverse effects*
chemical_list: D014364:Tryptophan