Study on the interaction between sucralfate and diclofenac/piroxicam in healthy volunteers.
The possible interaction between sucralfate (Ulcogant, CAS 54182-58-0) on the one hand and diclofenac (CAS 15307-86-5) and piroxicam (CAS 36322-90-4) on the other hand was investigated in two groups each consisting of twelve healthy volunteers. The AUC (0-t) was calculated at 1670 +/- 492 ng/ml x h for diclofenac alone and at 1817 +/- 682 ng/ml x h for diclofenac plus sucralfate. The mean AUC (0-t) for piroxicam alone was 91 +/- 19 micrograms/ml x h whilst that for piroxicam plus sucralfate was 91 +/- 20 micrograms/ml x h. The mean relative bioavailability was 116% for diclofenac plus sucralfate compared to diclofenac alone, and 100% for piroxicam plus sucralfate compared to piroxicam alone. Thus there is no interaction between sucralfate and diclofenac resp. piroxicam.
Ungethüm
W
W
Department of Clinical Pharmacology, Darmstadt, Fed. Rep. of Germany.
D000328:Adult; D001682:Biological Availability; D004008:Diclofenac / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D010894:Piroxicam / Q000493:pharmacokinetics / Q000494:pharmacology*; D011897:Random Allocation; D013392:Sucralfate / Q000493:pharmacokinetics / Q000494:pharmacology*
D010894:Piroxicam; D004008:Diclofenac; D013392:Sucralfate