Opioidergic inhibition of reflexes evoked by selective stimulation of sural nerve C fibres in the rabbit.
Reflexes were evoked in the gastrocnemius medialis (GM) muscle nerve by selective electrical stimulation of the non-myelinated C fibres of the ipsilateral sural nerve of decerebrated, spinalized rabbits. The opioid antagonist (-)-quadazocine (555 micrograms/kg i.v.) enhanced responses to sural C fibre stimulation to an average of 236% of pre-drug levels. In addition, C fibre-evoked reflexes were depressed for 7-9 min after repetitive activation of the high threshold axons of the common peroneal nerve, and this effect was reversed after quadazocine. Thus, GM responses to stimulation of non-myelinated sural afferent fibres are suppressed by endogenous opioid peptides, but the degree of inhibition does not appear to be as profound as that previously reported for reflexes evoked by myelinated fibres.
Clarke
R W
RW
Department of Physiology and Environmental Science, University of Nottingham, School of Agriculture, Loughborough, Leicestershire.
Harris
J
J
Ford
T W
TW
Taylor
J S
JS
D000818:Animals; D001392:Azocines / Q000494:pharmacology*; D003655:Decerebrate State; D004558:Electric Stimulation; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000502:physiology*; D007700:Kinetics; D009132:Muscles / Q000294:innervation*; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D009475:Neurons, Afferent / Q000187:drug effects; D010543:Peroneal Nerve / Q000187:drug effects; D011817:Rabbits; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D013497:Sural Nerve / Q000187:drug effects / Q000502:physiology*
D001392:Azocines; D004723:Endorphins; C035969:quadazocine