Differential c-myc protein expression in Burkitt's lymphomas and EBV-transformed lymphoblastoid lines.
The levels of c-myc protein expression in three types of Epstein-Barr virus (EBV) transformed human B-cell derived lines were examined with an ELISA assay. Six independently maintained sublines of the same EBV-transformed pro-B-cell line (FLEB-14), six B-cell lines (LCL) and six Burkitt's lymphoma lines (BL) were compared. The average amount of c-myc protein, calculated from at least three independent tests on each line, differed between the three groups. Expressed in relative units, the ratio of the means was 1:2:5 for the LCL:FLEB:BL lines. The differences were statistically significant at P less than 0.01.
Wennborg
A D
AD
Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden.
Altiok
E
E
Moore
J P
JP
Ernberg
I
I
Klein
G
G
D001402:B-Lymphocytes / Q000378:metabolism; D002051:Burkitt Lymphoma / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D002472:Cell Transformation, Viral / Q000502:physiology; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D015967:Gene Expression Regulation, Viral; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis*
D016271:Proto-Oncogene Proteins c-myc