title: Renal function in dry cleaning workers exposed to perchloroethylene.
abstract: Perchloroethylene (PCE) is a widely used dry cleaning and degreasing solvent. Although there is evidence in animals and humans for renal effects at extremely high doses, there are few studies of its potential renal toxicity at typical occupational concentrations. This study reports on the relationship of PCE in breath and estimates of chronic exposure with the urinary ratios of total urinary protein, albumin, and n-acetyl-glucosaminidase (NAG) to creatinine in dry cleaning workers exposed to PCE. Regression models including one or more exposure variables, demographic variables, mean arterial blood pressure (MAP), and the presence of diseases affecting kidney function were examined. Urine samples, breath samples, exposure histories, and medical histories were obtained from 192 dry cleaning workers. The results failed to demonstrate any consistent relationship between exposure and renal outcome variables. However, protein/creatinine and albumin/creatinine were significantly, although weakly and positively, associated with MAP; NAG/creatinine was weakly but significantly positively associated with age; mean NAG/creatinine was also higher in non-whites. The reasons why an association between exposure and renal outcome was not found are discussed.
authors.affiliation: School of Public Health, University of Michigan, Ann Arbor.
authors.forename: D
authors.initials: D
authors.lastname: Solet
authors.forename: T G
authors.initials: TG
authors.lastname: Robins
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000419:Albuminuria / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D001944:Breath Tests; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced / Q000652:urine; D007846:Laundering; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis*; D011507:Proteinuria / Q000139:chemically induced; D012044:Regression Analysis; D013750:Tetrachloroethylene / Q000009:adverse effects / Q000032:analysis / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000118:Acetylglucosaminidase; D013750:Tetrachloroethylene