Long-term vitreous replacement in primates with intravitreal Vitreon or Vitreon plus silicone.
Six African green monkeys (six eyes) underwent vitrectomy and vitreous replacement with Vitreon (perfluorophenanthrene) or Vitreon plus silicone. A seventh animal served as a control. Vitreon alone and in combination remained optically clear and allowed fundus examination up to 162 days. No toxic effects to the retina were detectable. Vitreon exhibited some degree of emulsification and formed some globules at 45 days postoperatively. Interestingly, Vitreon emulsification occurred at a later time (80 days) in one of the silicone plus Vitreon eyes. The combination of silicone plus Vitreon may offer the advantage of tamponading the inferior and superior retina in phakic eyes.
Peyman
G A
GA
Department of Ophthalmology, LSU Eye Center, Louisiana State University Medical Center, School of Medicine, New Orleans 70112-2234.
Conway
M D
MD
Soike
K F
KF
Clark
L C
LC
D000818:Animals; D002522:Chlorocebus aethiops; D004338:Drug Combinations; D005451:Fluorescein Angiography; D005466:Fluorocarbons / Q000633:toxicity*; D005654:Fundus Oculi; D008137:Longitudinal Studies; D010786:Photoreceptor Cells / Q000187:drug effects / Q000473:pathology; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D012167:Retinal Perforations / Q000601:surgery; D012827:Silicone Oils / Q000633:toxicity*; D014821:Vitrectomy
D004338:Drug Combinations; D005466:Fluorocarbons; D012827:Silicone Oils; C047722:perfluorophenanthrene