title: The role of Chlamydia trachomatis and Neisseria gonorrhoeae in the aetiology of ectopic pregnancy in Gabon.
abstract: OBJECTIVE
  To study the association between ectopic pregnancy and Chlamydia trachomatis and Neisseria gonorrhoeae.
  
  
  METHODS
  A prospective observational study with two comparison groups.
  
  
  METHODS
  A general hospital in Franceville, Gabon.
  
  
  METHODS
  Forty-five women with ectopic pregnancies and two comparison groups each of 45 women, one at 5 to 12 and the other at 32 to 41 weeks gestation.
  
  
  METHODS
  Serum levels of IgG and IgA antibodies to C. trachomatis (L1 and rMOMP) and N. gonorrhoeae (pili) in all the women. In the women with ectopic pregnancy peritoneal adhesions were scored and in 40 women samples of tube were cultured for organisms being studied.
  
  
  RESULTS
  IgG and IgA antibodies to C. trachomatis (L1) were detected in 84% of the ectopic group and 53 and 39% of the comparison groups (P less than 0.0001). IgG and IgA antibodies to N. gonorrhoeae occurred in 49, 28 and 18% and 49, 28 and 26% of the groups but the differences were not statistically significant. Adhesions were positively associated with the antibodies. C. trachomatis was cultured from the tubes of 71% of the women with ectopic pregnancy.
  
  
  CONCLUSIONS
  Infection with chlamydia, and probably with N. gonorrhoeae, is an important factor in the causation of ectopic pregnancy in Gabon.
authors.affiliation: Centre International de Recherche de Franceville, Gabon.
authors.forename: Y
authors.initials: Y
authors.lastname: Ville
authors.forename: M
authors.initials: M
authors.lastname: Leruez
authors.forename: E
authors.initials: E
authors.lastname: Glowaczower
authors.forename: J N
authors.initials: JN
authors.lastname: Robertson
authors.forename: M E
authors.initials: ME
authors.lastname: Ward
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D002690:Chlamydia Infections / Q000150:complications / Q000175:diagnosis*; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D005260:Female; D006069:Gonorrhea / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D011271:Pregnancy, Ectopic / Q000382:microbiology*; D011446:Prospective Studies
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G