title: Caries incidence after topical application of varnishes containing different concentrations of sodium fluoride: 3-year results.
abstract: Previous studies have shown that topical application of the fluoride varnish Duraphat reduces caries incidence. The aim of the present study was to compare the caries inhibiting effect of a new fluoride varnish (Carex) containing 1.8% fluoride (F) with that of Duraphat (2.26% F). Informed consent was obtained from the guardians of 495 children 10-12 yr old in Voss Dental Health District (low F area). The children were randomly allocated to two groups. One group of subjects received 6-monthly application of Duraphat (n = 185), the other Carex (n = 165). Ethical considerations precluded the use of a placebo varnish. All participants received dental examinations including one pair of posterior bitewing radiographs and necessary dental care annually. One trained examiner interpreted bitewing radiographs blindly. Total 3-yr net DFS increment for 24 posterior approximal surfaces was 2.63 (SD = 3.81) in the Duraphat group and 2.12 (SD = 3.50) in the Carex group. DMFS increments based on 40 posterior occlusal and approximal surfaces were 5.21 (SD = 5.79) and 4.04 (SD = 4.92), respectively. Thus the results indicate a comparable efficacy for Carex and Duraphat at the caries activity level exhibited by these study participants.
authors.affiliation: Department of Community Dentistry, University of Bergen, Norway.
authors.forename: O
authors.initials: O
authors.lastname: Haugejorden
authors.forename: A
authors.initials: A
authors.lastname: Nord
mesh_terms: D000704:Analysis of Variance; D002648:Child; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D005260:Female; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D008297:Male; D010150:Paint; D010895:Pit and Fissure Sealants / Q000627:therapeutic use; D012737:Sex Factors; D012969:Sodium Fluoride / Q000627:therapeutic use*
chemical_list: C070175:Carex; D005460:Fluorides, Topical; D010895:Pit and Fissure Sealants; C023807:sodium fluoride topical preparation; D012969:Sodium Fluoride