Bone-alkaline phosphatase as indicator of bone formation.
Bone-alkaline phosphatase was determined in patients at risk of osteoporosis due to treatment with oral corticosteroids, and in patients at risk of increased bone synthesis because of treatment with cyclosporin. Both a significant decrease of bone-alkaline phosphatase during corticosteroid treatment, and a significant increase of bone-alkaline phosphatase during cyclosporin treatment could be demonstrated. It is concluded that bone-alkaline phosphatase is a useful parameter for monitoring changes in bone formation.
van Straalen
J P
JP
Department of Clinical Chemistry, Academic Medical Centre, Amsterdam, The Netherlands.
Sanders
E
E
Prummel
M F
MF
Sanders
G T
GT
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood* / Q000187:drug effects; D001379:Azathioprine / Q000494:pharmacology; D001507:Beclomethasone / Q000494:pharmacology; D001846:Bone Development / Q000502:physiology*; D001842:Bone and Bones / Q000201:enzymology*; D016572:Cyclosporine / Q000494:pharmacology; D005260:Female; D006111:Graves Disease / Q000201:enzymology; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology; D008875:Middle Aged; D011241:Prednisone / Q000494:pharmacology
D016572:Cyclosporine; D000469:Alkaline Phosphatase; D001507:Beclomethasone; D001379:Azathioprine; D011241:Prednisone