The efficacy of mezlocillin-amikacin combination in febrile neutropenic children with oncologic disease.
The efficacy of mexlocillin-amikacin combination as empirical therapy for febrile neutropenic patients was studied in 30 children (21 males, 9 females) with various oncologic diseases aged 1-15 years (mean age 7.3 +/- 4.4) in the Istanbul Medical School, Oncologic Disease Research and Treatment Center, and Department of Pediatric Hematology-Oncology between January 1 and May 31, 1988. The response rate was 76.6%. Profound persistent granulocytopenia (fewer than 100 ml) was present in 70% of the patients. In 63.3% of patients, the infections were microbiologically documented (60%) Gram(+) and 40% Gram(-). The combination was well tolerated with hepatic and/or renal disturbances in 8 cases (26.6%). We conclude that mezlocillin-amikacin is an effective empirical combination in the initial treatment of infections in febrile neutropenic children with various oncologic diseases.
Zülfikar
B
B
Istanbul University, Istanbul Medical School, Türkiye.
Devecioğlu
O
O
Anak
S
S
Ovali
F
F
Gedikoğlu
G
G
D000293:Adolescent; D000583:Amikacin / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D006192:Haemophilus Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008297:Male; D008802:Mezlocillin / Q000009:adverse effects / Q000627:therapeutic use*; D016870:Neisseriaceae Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy; D009369:Neoplasms / Q000150:complications*; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology; D013203:Staphylococcal Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy; D013290:Streptococcal Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy
D000583:Amikacin; D008802:Mezlocillin