title: Umbilical metastasis (Sister Joseph's nodule) from carcinoma of the vagina.
abstract: A case is reported of a squamous cell carcinoma of the vagina with metastasis to the umbilicus (Sister Mary Joseph's nodule). Systemic cisplatinum chemotherapy resulted in partial response, however, the "nodule" was a sign of poor prognosis and indicative of short-term survival. To the best of our knowledge, this is the first report of umbilical metastasis from a primary carcinoma of the vagina.
authors.affiliation: Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors.forename: Y N
authors.initials: YN
authors.lastname: Bakri
authors.forename: J
authors.initials: J
authors.lastname: Subhi
authors.forename: E
authors.initials: E
authors.lastname: Hashim
authors.forename: M
authors.initials: M
authors.lastname: Senoussi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000556:secondary*; D002945:Cisplatin / Q000627:therapeutic use; D004850:Eponyms; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D014472:Umbilicus; D014625:Vaginal Neoplasms / Q000473:pathology*
chemical_list: D002945:Cisplatin