title: Decreased hospitalization and increased height velocity in focal segmental glomerulosclerosis responsive to ciclosporin A.
abstract: Eleven pediatric patients with nephrosis and focal segmental glomerulosclerosis were treated with long-term (8-38 months) ciclosporin A in combination with steroids. All had abnormal height-velocity curves and multiple hospitalizations for complications of nephrosis. Eight patients attained remission with a dramatic improvement in growth and decrease in necessity for hospitalization for therapy of nephrosis complications, while maintaining adequate renal function. Three nonresponders developed end-stage renal disease. Long-term ciclosporin A therapy may be of benefit in steroid-resistant nephrosis in childhood.
authors.affiliation: Department of Pediatrics, Hôpital Ste-Justine, University of Montreal, Canada.
authors.forename: S
authors.initials: S
authors.lastname: O'Regan
authors.forename: G F
authors.initials: GF
authors.lastname: Murphy
authors.forename: P
authors.initials: P
authors.lastname: Robitaille
authors.forename: P
authors.initials: P
authors.lastname: Russo
authors.forename: J
authors.initials: J
authors.lastname: Klassen
mesh_terms: D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy*; D006128:Growth / Q000187:drug effects; D006760:Hospitalization; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D012074:Remission Induction; D013997:Time Factors
chemical_list: D016572:Cyclosporine