Isolation and structural elucidation of new 18-membered macrolide antibiotics, viranamycins A and B.
Two cytotoxic antibiotics, designated viranamycins A and B, were isolated from the culture broth of Streptomyces sp. CH41. Their structures were elucidated as new 18-membered macrolides related to virustomycin A and concanamycin A from NMR spectral analysis. Viranamycins A and B inhibited the growth of P388 mouse leukemia and KB human squamous-cell-carcinoma cells.
Hayakawa
Y
Y
Institute of Applied Microbiology, University of Tokyo, Japan.
Takaku
K
K
Furihata
K
K
Nagai
K
K
Seto
H
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D005285:Fermentation; D006801:Humans; D018942:Macrolides; D051379:Mice; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D018942:Macrolides; C072731:viranamycin A; C072730:viranamycin B