Lactobacillus casei-induced polyarthritis in Lewis rats: histopathological scoring system for evaluation of anti-rheumatic drugs.
A histopathological scoring system which grades drug effects on cellular infiltration, pannus formation, cartilage degradation and bone resorption in L. casei-induced polyarthritis in rats is described. Reference anti-rheumatic and anti-inflammatory agents administered on days 2-60 after induction of arthritis were evaluated for effects on paw swelling weekly and graded histopathologic changes on day 60. This animal model affords a tool to evaluated therapeutic agents on the joint destruction resulting from chronic inflammation.
O'Byrne
E M
EM
CIBA-GEIGY Corporation, Research Department, Summit, NJ 07901.
Roberts
E D
ED
Rubin
A S
AS
Blancuzzi
V
V
Wilson
D
D
Hall
N R
NR
Lehman
T J
TJ
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy* / Q000473:pathology; D001862:Bone Resorption / Q000188:drug therapy / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology; D002473:Cell Wall / Q000737:chemistry; D004341:Drug Evaluation; D005260:Female; D007596:Joints / Q000473:pathology; D007780:Lacticaseibacillus casei; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents