[Homeorrhetic modifications produced by a beta-agonist in the muscle and adipose tissues of the rat].
A repartitioning effect was observed in young rats after a chronic treatment with a nonselective beta-agonist administered subcutaneously. An increase in carcass protein (P less than 0.05) accompanied by a reduction in fat stores (P less than 0.01) and an increase in back fat oxygen consumption (P less than 0.05) were found in treated animals. The muscle mass accretion should be attributed to a reduction in muscle protein degradation, based on lower activity of the proteolytic enzyme cathepsin A in treated rats, rather than to changes in protein synthesis, assessed by an amino-acid incorporation technique. The anabolic actions of this compound apparently involve changes in muscle prostaglandin E2 and reduction-oxidation state.
Portillo
M P
MP
Université Paul-Sabatier, faculté de médecine, Toulouse, France.
Martinez
J A
JA
Larralde
J
J
D000273:Adipose Tissue / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002268:Carboxypeptidases / Q000032:analysis; D043402:Cathepsin A; D002403:Cathepsins / Q000032:analysis; D015232:Dinoprostone / Q000378:metabolism; D007279:Injections, Subcutaneous; D009921:Metaproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D024510:Muscle Development; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D009124:Muscle Proteins; D009921:Metaproterenol; D002268:Carboxypeptidases; D002403:Cathepsins; D043402:Cathepsin A; D015232:Dinoprostone
Modifications homéorhétiques produites par un beta-agoniste dans les tissus musculaires et adipeux chez le rat.