[Current aspects of Paget's bone disease].
The clinical and laboratory signs, as well as the imaging and course of Paget's disease of bone, are now well known. This chronic and usually benign disease is characterized by excessive remodelling of bone tissue, associated with an increase, sometimes considerable, of osteoclast resorption and osteoblast formation activities. Studies conducted during the last two decades were aimed at determining more precisely some aspects of the disease, notably: its epidemiological aspect and in particular its geographical distribution; its aetiological aspect using data obtained from electron microscopy, immunocytology and hydridization in situ, which has led to the hypothesis of a viral origin, and finally its therapeutic aspect with the recent introduction of truly effective treatments such as calcitonin and biphosphonates.
Baslé
M F
MF
Laboratoire d'Histologie-Embryologie, Faculté de Médecine, ANGERS, France.
Audran
M
M
Rebel
A
A
D001842:Bone and Bones / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D010001:Osteitis Deformans / Q000209:etiology / Q000503:physiopathology / Q000628:therapy
Aspects actuels de la maladie osseuse de Paget.