title: [A new emphasis on the diagnosis of malignant hyperthermia using the in vitro contracture test?].
abstract: In accordance with the protocol of the European Malignant Hyperpyrexia Group, an account is given of the experience regarding establishment of the "in vitro contracture test" for diagnosis and exclusion of malignant hyperpyrexia disposition at the University Clinic of Leipzig. Since its commencement in 1986 these diagnostic possibilities are being increasingly utilized, and--basing on 76 MH manifestations and suspected cases--324 persons have been examined until now. Besides the representation of the methodical features (e.g. performance of biopsy in tranquanalgesia in children), emphasis was on the safety of executing this test (attaining higher specificity, total absence of MH manifestations). The epidemiological study of the results shows the varying knowledge of physicians and the interference by insufficient investigation alternatives in individual areas. On the basis of the results, the use of the in vitro contracture test is recommended in all MH suspected cases by the authorized and qualified regional centres.
authors.affiliation: Klinik für Anästhesiologie und Intensivtherapie, Bereich Medizin, Universität Leipzig.
authors.forename: D
authors.initials: D
authors.lastname: Olthoff
authors.forename: C D
authors.initials: CD
authors.lastname: Meinecke
mesh_terms: D000293:Adolescent; D000328:Adult; D002110:Caffeine; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D006221:Halothane; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D008305:Malignant Hyperthermia / Q000453:epidemiology / Q000503:physiopathology*; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D012189:Retrospective Studies
chemical_list: D002110:Caffeine; D006221:Halothane
vernacular_title: Neue Akzente bei der Maligne-Hyperthermie-Diagnostik mittels in-vitro-Kontrakturtest?