ACE inhibitor fetopathy and hypocalvaria: the kidney-skull connection.
Two cases of angiotensin converting enzyme inhibitor fetopathy with renal tubular dysgenesis and severely underdeveloped calvarial bone are described. Six additional, unexposed cases of hypocalvaria are described, and possible links between calvarial development and fetal hypotension and/or chronic hypoxia are explored.
Barr
M
M
Department of Pediatrics, University of Michigan, Ann Arbor 48109.
Cohen
M M
MM
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D000293:Adolescent; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005311:Fetal Hypoxia / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities*; D007684:Kidney Tubules / Q000002:abnormalities*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy; D012886:Skull / Q000002:abnormalities*
D000806:Angiotensin-Converting Enzyme Inhibitors