title: Fictive cough in the cat.
abstract: Experiments were performed to determine whether cough could be elicited in paralyzed cats ventilated on a respiratory cycle-triggered pump. Midcollicular decerebrate cats were paralyzed and artificially ventilated on a phrenic-triggered pump. Phrenic and cranial iliohypogastric nerve efferent activities were recorded. Cough was elicited by electrical stimulation of the superior laryngeal nerve (SLN) or probing the intrathoracic trachea. Fictive coughs induced by electrical stimulation of the SLN or mechanical stimulation of the intrathoracic trachea consisted of large-amplitude bursts in phrenic discharge immediately followed by large bursts in cranial iliohypogastric discharge. During fictive cough, phrenic postinspiratory discharge was reduced relative to control cycles. Codeine (0.03-1 mg/kg iv) decreased both SLN- and probe-induced fictive cough. I conclude that fictive cough can be produced in paralyzed cats ventilated on a phrenic-triggered pump. Furthermore, fictive cough can be produced in the absence of afferent feedback associated with active expiration.
authors.affiliation: Department of Allergy, Schering-Plough Research, Bloomfield, New Jersey 07003.
authors.forename: D C
authors.initials: DC
authors.lastname: Bolser
mesh_terms: D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D002415:Cats; D003061:Codeine / Q000494:pharmacology; D003371:Cough / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D003655:Decerebrate State / Q000503:physiopathology; D004558:Electric Stimulation; D005246:Feedback; D007823:Laryngeal Nerves / Q000503:physiopathology; D010791:Phrenic Nerve / Q000503:physiopathology; D010812:Physical Stimulation; D015656:Respiratory Mechanics / Q000502:physiology; D014132:Trachea / Q000503:physiopathology
chemical_list: D003061:Codeine