title: Experience of percutaneous transluminal coronary angioplasty in orthotopic cardiac transplant recipients.
abstract: We evaluated the role of percutaneous transluminal coronary angioplasty (PTCA) in a series of orthotopic cardiac transplant recipients with severe epicardial coronary occlusive disease. Ten orthotopic cardiac transplant patients treated by PTCA up to March 1990 were reviewed. All had significant epicardial coronary artery lesions (greater than 70% stenosis compared with the adjacent healthy artery) and exercise electrocardiogram or isotope perfusion evidence of myocardial ischaemia in the relevant region. Primary angiographic PTCA success was achieved in 12 of the 16 lesions attempted (75%). Mean stenosis improvement was from 80% of adjacent healthy artery (range 70-90%) to 12% (range 0-20%). Median angiographic follow-up of 9 months (2-25 months) is available for all patients. The mean recurrence rate is 33% (4 of 12 successfully treated lesions) defined as greater than 50% reduction in the original gain at the PTCA. We have shown that PTCA is technically possible in a series of cardiac transplant recipients. The primary success and recurrence rates are comparable to the use of PTCA in conventional atherosclerotic coronary disease.
authors.affiliation: Cardiac Unit, Papworth Hospital, Cambridge, U.K.
authors.forename: P A
authors.initials: PA
authors.lastname: Mullins
authors.forename: L M
authors.initials: LM
authors.lastname: Shapiro
authors.forename: D A
authors.initials: DA
authors.lastname: Aravot
authors.forename: J P
authors.initials: JP
authors.lastname: Scott
authors.forename: S R
authors.initials: SR
authors.lastname: Large
authors.forename: J
authors.initials: J
authors.lastname: Wallwork
authors.forename: P M
authors.initials: PM
authors.lastname: Schofield
mesh_terms: D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D003324:Coronary Artery Disease / Q000628:therapy*; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D016896:Treatment Outcome