Neurotropism, frozen muscle grafts and other conduits.
Axonal regeneration following nerve transection requires a number of cellular and biochemical phenomena in the axons as well as the nerve cell bodies. The nerve cells must survive the trauma. Since axonal severance means amputation of a large axoplasmic volume from the remaining parts of the nerve cell, the cell body must prepare for increased synthesis of axoplasm to replace the missing parts. A sprouting process must be initiated at the level of transection. Regenerating axonal processes are to regenerate towards peripheral targets, a process regulated by an interaction between genetic mechanisms in the nerve cell body and biochemical information at the molecular level along the pathway.
Lundborg
G
G
Department of Hand Surgery, Lund University General Hospital, Malmö, Sweden.
D000818:Animals; D001369:Axons / Q000502:physiology; D006801:Humans; D009132:Muscles / Q000294:innervation / Q000637:transplantation; D009414:Nerve Growth Factors / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D059348:Peripheral Nerve Injuries; D019736:Prostheses and Implants; D012828:Silicones
D009414:Nerve Growth Factors; D012828:Silicones