title: Cervical intraepithelial neoplasia extending to the margins of resection in conization of the cervix.
abstract: Conization of the cervix is still widely utilized under certain conditions for the diagnosis and treatment of cervical intraepithelial neoplasia (CIN). Little has been written about the management of disease extending to the margins of resection. Ninety-four patients underwent conization of the cervix for cervical intraepithelial neoplasia (CIN). Nineteen (20%) had positive margins of resection; 10 (56%) of them had no evidence of disease in follow-up of one to four years. The inflammatory response of healing may play a role in a cure. Positive margins of resection and persistent disease, noted in 44%, were positively associated with higher grades of CIN and smoking. Smoking was also a risk factor for recurrent disease in those with negative margins of resection.
authors.affiliation: Department of Obstetrics and Gynecology, Marietta Memorial Hospital, Ohio.
authors.forename: C D
authors.initials: CD
authors.lastname: White
authors.forename: W L
authors.initials: WL
authors.lastname: Cooper
authors.forename: R R
authors.initials: RR
authors.lastname: Williams
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D003127:Colposcopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis / Q000601:surgery; D012008:Recurrence; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000601:surgery*