title: A novel Robertsonian translocation in a family of Walker hounds.
abstract: A 5-year-old female Walker hound was presented to the Washington State University Veterinary Teaching Hospital as a result of a narrowing of the vulva, which prevented natural breeding. All other physical and clinical findings were normal. Cytogenetic analysis disclosed a chromosome number of 77, with three metacentric chromosomes comprised of two X chromosomes and a Robertsonian translocation of two acrocentric autosomes, chromosomes 21 and 33. Cytogenetic analysis of two full-sister siblings with histories of absence of estrus disclosed one with the same translocation and one with a normal female chromosome constitution. The propositus was artificially inseminated with semen from a karyotypically normal male Walker hound and gave birth to nine live grossly normal pups, six females and three males. Another female pup was stillborn but was grossly normal. Cytogenetic analysis of the live pups disclosed that four (three males and one female) of the nine had the same translocation in all lymphocytes. The remaining five pups (five females) had normal female chromosome constitutions. The litter size was average for this breed. This is a previously unreported Robertsonian translocation in dogs.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
authors.forename: D M
authors.initials: DM
authors.lastname: Stone
authors.forename: W D
authors.initials: WD
authors.lastname: Mickelsen
authors.forename: P B
authors.initials: PB
authors.lastname: Jacky
authors.forename: D J
authors.initials: DJ
authors.lastname: Prieur
mesh_terms: D000818:Animals; D002871:Chromosome Banding / Q000662:veterinary; D004285:Dogs / Q000235:genetics*; D005260:Female; D007621:Karyotyping / Q000662:veterinary; D008297:Male; D014178:Translocation, Genetic