title: Neuronal migration disorders: a contribution of modern neuroimaging to the etiologic diagnosis of epilepsy.
abstract: Computed tomography and magnetic resonance imaging enable the identification of neuronal migration disorders during life. Several specific syndromes have been identified and early diagnosis of previously unrecognized entities is now possible. We report 51 patients with imaging. Thirty-two had a single widespread cortical dysplastic lesion. Twenty-eight had focal corticectomies. From a pathological standpoint, these encompassed focal cortical dysplasia (14 cases) and forme fruste of tuberous sclerosis (10 cases). These two groups of patients were indistinguishable from the clinical and radiological standpoint. In only two was the MRI examination normal. In addition, there were 10 with bilateral perisylvian dysplasia, four with diffuse cortical dysplasia or the "double cortex" syndrome, three with hemimegalencephaly, one with megalencephaly, and one with nodular neuronal heterotopia. The electroclinical and imaging findings led to the development of specific surgical strategies for the alleviation of the intractable seizures in each of these radiologically-defined syndromes.
authors.affiliation: Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Palmini
authors.forename: F
authors.initials: F
authors.lastname: Andermann
authors.forename: A
authors.initials: A
authors.lastname: Olivier
authors.forename: D
authors.initials: D
authors.lastname: Tampieri
authors.forename: Y
authors.initials: Y
authors.lastname: Robitaille
authors.forename: D
authors.initials: D
authors.lastname: Melanson
authors.forename: R
authors.initials: R
authors.lastname: Ethier
mesh_terms: D000293:Adolescent; D000328:Adult; D000654:Amobarbital; D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D002540:Cerebral Cortex / Q000002:abnormalities / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009474:Neurons / Q000473:pathology*; D013226:Status Epilepticus / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D000654:Amobarbital