The effect of cyclosporin on lower limb blood flow in renal transplant recipients.
We investigated the effect of electively converting stable renal allograft recipients from cyclosporin A (CyA) to prednisolone and azathioprine on limb blood. We used a non-invasive method designed to measure the hyperaemic blood flow to the lower limb following a standard ischaemic insult. The hyperaemic blood flow was greater during CyA therapy--median 14 ml/100 ml tissue per minute (95% confidence limits 10.5-16.5)--than that after conversion--median 11 ml/100 ml tissue per minute (8.3-13.8; P less than 0.01). By increasing peripheral vascular resistance and reducing limb blood flow, CyA may have caused an increase in the degree of ischaemia, so resulting in a greater hyperaemic response.
Davenport
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Department of Renal Research, St. James's University Hospital, Leeds, UK.
Parkin
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D000328:Adult; D000368:Aged; D001379:Azathioprine / Q000008:administration & dosage; D001775:Blood Circulation / Q000187:drug effects; D001783:Blood Flow Velocity / Q000187:drug effects; D003404:Creatinine / Q000097:blood / Q000652:urine; D016572:Cyclosporine / Q000627:therapeutic use*; D004452:Echocardiography; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage
D016572:Cyclosporine; D003404:Creatinine; D001379:Azathioprine; D011241:Prednisone