title: [An experimental infection of the seal Phoca sibirica with the morbilli virus].
abstract: A Baikal seal (Phoca sibirica) was experimentally infected with Baikal seal morbillivirus (BSMV) isolated from Baikal seals during an epizootic in 1987-1988. The seal was infected with BSMV with an infectious titer of 10(7.0) TCD50/ml, and daily observations of the animal clinical condition were made. The virus-specific antibodies in the seal serum were determined by ELISA and virus neutralization test. The clinical picture showed a mild infection. The ELISA-active antibodies were detected 10 days postinfection and reached the maximum in 20 days. Virus-neutralizing antibodies were detected in 16 days after infection, reached the maximum titer of 1:640 in 20 days and remained at this level for 39 days (the observation period). These data indicate that BSMV can induce a disease in the natural host with production of virus-neutralizing antibodies. The results of this work and the earlier reports show that the epizootic in Baikal seals was induced by BSMV.
authors.forename: A M
authors.initials: AM
authors.lastname: Titenko
authors.forename: T I
authors.initials: TI
authors.lastname: Borisova
authors.forename: A M
authors.initials: AM
authors.lastname: Beĭm
authors.forename: S S
authors.initials: SS
authors.lastname: Novozhilov
authors.forename: V N
authors.initials: VN
authors.lastname: Kudelin
authors.forename: V L
authors.initials: VL
authors.lastname: Zorin
authors.forename: V P
authors.initials: VP
authors.lastname: Kumarev
authors.forename: V S
authors.initials: VS
authors.lastname: Kolesnik
mesh_terms: D000820:Animal Diseases / Q000175:diagnosis; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000918:Antibody Specificity; D008457:Measles / Q000175:diagnosis*; D008459:Measles virus / Q000276:immunology; D046048:Seals, Earless / Q000276:immunology; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral
vernacular_title: Eksperimental'noe infitsirovanie nerpy Phoca sibirica morbillivirusom.