title: Synthesis and anticonvulsant properties of some novel quinazolone-thiosemicarbazone and 4-thiazolidone derivatives.
abstract: Diverse biological activities have been found in compounds having a quinazolinone ring system. A large number of 4(3H)-quinazolinones, in particular those possessing 2-alkyl-3-aryl, 2,3-dialkyl, and 2-alkyl-3-amino substitution, have been evaluated for pharmacological activity. On the other hand, thiazolidone derivatives are reported to have anesthetic, anticonvulsant, and hypnotic activity.
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Fateh University, Tripoli, Libya.
authors.forename: S A
authors.initials: SA
authors.lastname: el-Feky
authors.forename: Z K
authors.initials: ZK
authors.lastname: Abd el-Samii
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D011799:Quinazolines; D013844:Thiazoles; D013882:Thiosemicarbazones
chemical_list: D000927:Anticonvulsants; D011799:Quinazolines; D013844:Thiazoles; D013882:Thiosemicarbazones