[Analysis of chromosome aberrations and prognosis of bone marrow syndrome severity in acute radiation injuries in man].
Biological dose indication using chromosomal aberrations analysis is a reliable method of diagnosing acute radiation disease and prognosing bone marrow syndrome severity. Cytogenetic methods permit one not only to estimate the mean radiation dose in the subjects exposed that is most important in case of relatively uniform irradiation, but also to reveal the non-uniformity of radiation exposure. Estimation of aberrant cells in bone marrow puncture biopsy specimens obtained from different sites of the hemopoietic tissue and analysis of chromosomal aberrations in peripheral blood lymphocyte cultures can be used for this purpose. Materials including those obtained at the Chernobyl accident were analyzed with the use of the above methods, their advantages and shortcomings are considered, and equations of dose-response curves are presented.
Piatkin
E K
EK
Nugis
V Iu
VIu
Chirkov
A A
AA
D001855:Bone Marrow Diseases / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D006801:Humans; D011379:Prognosis; D011832:Radiation Injuries / Q000235:genetics*; D012720:Severity of Illness Index
Analiz aberratsiĭ khromosom i prognozirovanie tiazhesti kostno-mozgovogo sindroma pri ostrykh radiatsionnykh porazheniiakh cheloveka.