[Effect of exogenous neoplasm DNA on the course of Swetz leukemia in non-inbred rats of different age groups].
Experiments on 150 non-inbred white rats have shown that preliminary administration of high polymer native DNA isolated from Swetz leukemia tumor suppresses the tumor growth. Tumor DNA combined with BCG vaccine in young animals suppresses and in old ones stimulates the tumor growth. These results correlate with DNA and CIC content in the blood serum. Due to the tumor growth suppression the animals' life increases by 40%. Administration of BCG vaccine only does not prevent the development of tumor in usual terms.
Sarnitskiĭ
I P
IP
Shalimov
S A
SA
Trokhimenko
E P
EP
Keĭsevich
L V
LV
Cherviak
P I
PI
D000367:Age Factors; D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis / Q000276:immunology; D001500:BCG Vaccine / Q000008:administration & dosage*; D002455:Cell Division / Q000502:physiology; D004273:DNA, Neoplasm / Q000008:administration & dosage* / Q000302:isolation & purification; D006131:Growth Inhibitors; D006133:Growth Substances; D007942:Leukemia, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008297:Male; D051381:Rats; D014020:Tissue Extracts / Q000008:administration & dosage* / Q000302:isolation & purification
D000912:Antibodies, Neoplasm; D001500:BCG Vaccine; D004273:DNA, Neoplasm; D006131:Growth Inhibitors; D006133:Growth Substances; D014020:Tissue Extracts
Vliianie ékzogennoĭ opukholevoĭ DNK na techenie leĭkoza Shwetsa u besporodnykh krys razlichnykh vozrastnykh grupp.