The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon.
The styrylpyrone, goniodiol-7-monoacetate [1] [6R-(7R,8R-dihydro-7-acetoxy-8-hydroxystyryl)-5, 6-dihydro-2-pyrone], has been isolated from Goniothalamus amuyon, and its detailed molecular structure has been determined by X-ray crystallographic analysis. Goniodiol-7-monoacetate showed potent (ED50 values less than 0.1 microgram/ml) cytotoxicities against KB, P-388, RPMI, and TE671 tumor cells.
Wu
Y C
YC
School of Pharmacy, Department of Microbiology, Kaohsiung Medical College, Taiwan, Republic of China.
Duh
C Y
CY
Chang
F R
FR
Chang
G Y
GY
Wang
S K
SK
Chang
J J
JJ
McPhail
D R
DR
McPhail
A T
AT
Lee
K H
KH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D003460:Crystallization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D015394:Molecular Structure; D010946:Plants, Medicinal; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013343:Styrenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D011753:Pyrones; D013343:Styrenes; C073082:goniodiol-7-monoacetate