title: Subchronic oral toxicity of pyridostigmine bromide in rats.
abstract: This study evaluated the oral toxicity of pyridostigmine bromide in Sprague-Dawley rats when administered for 13 weeks by daily gavage. Groups of 10 rats/sex received doses of 0, 5, 15, 30, or 60 mg/kg/day. Toxicity was limited to exaggerated cholinergic stimulation at doses of 15 mg/kg/day or greater. Significant findings included tremors and inhibition of RBC acetylcholinesterase. Thus, 5 mg/kg/day of pyridostigmine bromide appears to be the no observed toxic effect level under the conditions of the present investigation.
authors.affiliation: Department of Pharmacology, University of Illinois, Chicago 60680.
authors.forename: B S
authors.initials: BS
authors.lastname: Levine
authors.forename: R
authors.initials: R
authors.lastname: Long
authors.forename: H
authors.initials: H
authors.lastname: Chung
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D006403:Hematologic Tests; D008297:Male; D011729:Pyridostigmine Bromide / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D013997:Time Factors
chemical_list: D011729:Pyridostigmine Bromide