title: Nephrotoxicity of aminoglycosides, polypeptides and cephalosporins in cancer patients.
abstract: The nephrotoxicity of various combinations of antibiotics--aminoglycosides, cephalosporins, vancomycin, amphotericin B--in 171 oncologic patients is described. The most nephrotoxic combination seems to be cefotaxime plus gentamicin, ceftriaxone plus amikacin and amphotericin B with cephalosporin, vancomycin or aminoglycoside. Less toxic was netilmicin with penicillin or cephalosporin, and vancomycin.
authors.affiliation: Department of Clinical Oncology, Postgraduate Medical Institute, Bratislava, Czechoslovakia.
authors.forename: V
authors.initials: V
authors.lastname: Krcméry
authors.forename: P
authors.initials: P
authors.lastname: Fuchsberger
authors.forename: M
authors.initials: M
authors.lastname: Gocár
authors.forename: T
authors.initials: T
authors.lastname: Salát
authors.forename: J
authors.initials: J
authors.lastname: Bodnárová
authors.forename: R
authors.initials: R
authors.lastname: Sobota
authors.forename: I
authors.initials: I
authors.lastname: Koza
authors.forename: J
authors.initials: J
authors.lastname: Svec
mesh_terms: D000617:Aminoglycosides; D000666:Amphotericin B / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D009369:Neoplasms / Q000150:complications*; D012189:Retrospective Studies; D014640:Vancomycin / Q000009:adverse effects*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D014640:Vancomycin; D000666:Amphotericin B