Reduced thrombogenicity of artificial materials by coating with ADPase.
A novel coating solution for the improvement of biocompatibility of polyurethane-based vascular prostheses was tested in rabbits and rats in vivo. Segments of coated and uncoated vascular prostheses were implanted into the peritoneal cavity of rats, followed by induction of experimental haemorrhage; otherwise whole vascular prostheses were implanted in the carotid artery of rabbits using microsurgical procedures. While in both rats and rabbits, the uncoated material showed abundant formation of fibrinoid thrombi, clear reduction of thrombus formation was seen in all ADPase coated materials following implantation in vivo.
Bakker
W W
WW
Department of Pathology, University Hospital Groningen, The Netherlands.
van der Lei
B
B
Nieuwenhuis
P
P
Robinson
P
P
Bartels
H L
HL
D000818:Animals; D001081:Apyrase; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D008297:Male; D008422:Materials Testing; D009504:Neutrophils / Q000473:pathology; D011140:Polyurethanes; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew; D013927:Thrombosis / Q000473:pathology / Q000517:prevention & control*
D001672:Biocompatible Materials; D011140:Polyurethanes; D001081:Apyrase