Effect of tiapride on electroacupuncture analgesia.
Tiapride icv 400 micrograms/rabbit exhibited analgesic and synergistic effects on electroacupuncture analgesia (EAA) in rabbits. Both electroacupuncture (EA) and tiapride (icv 400 micrograms/rabbit) enhanced the beta-endorphin-like immunoreactive substance (beta-EPIS) level in cerebrospinal fluid (CSF) measured by radioimmunoassay (RIA). When EA and tiapride were used in combination, a further increase of beta-EPIS content was found. The results suggested that promotion of beta-EPIS release by tiapride may be one of the mechanisms of synergistic effect of tiapride on EAA.
Dai
J L
JL
Department of Neurobiology, Shanghai Medical University, China.
Xu
S F
SF
D015667:Acupuncture Analgesia; D000818:Animals; D015671:Electroacupuncture; D005260:Female; D008297:Male; D010146:Pain / Q000503:physiopathology*; D011817:Rabbits; D011863:Radioimmunoassay; D012684:Sensory Thresholds / Q000187:drug effects; D013976:Tiapamil Hydrochloride / Q000494:pharmacology*; D001615:beta-Endorphin / Q000134:cerebrospinal fluid
D001615:beta-Endorphin; D013976:Tiapamil Hydrochloride