Complicated problems in osteogenic sarcoma including pulmonary metastasis, second bone involvement and cure rates.
A desirable goal in the treatment of osteogenic sarcoma is preservation of a limb, without sacrificing the principles of cancer surgery. This study describes the author's experience at the Memorial Sloan-Kettering Cancer Center in New York with limb salvage surgery for osteogenic sarcoma. One hundred ninety two patients are included in this study. The study shows that pre-operative chemotherapy is successful as demonstrated by the improved cure rates of each resection group. It was also found that limb sparing surgery is successful with or without chemotherapy as long as the surgical margins are adequate. Pulmonary resection surgery has also been shown to be successful as has surgery for a second bone involvement.
Marcove
R C
RC
Department of Orthopedics, Memorial Sloan-Kettering Cancer Center, New York NY 10021.
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D005121:Extremities / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012516:Osteosarcoma / Q000473:pathology / Q000556:secondary / Q000601:surgery; D011300:Preoperative Care
D000970:Antineoplastic Agents