title: Para-urethral collagen implantation for female stress incontinence.
abstract: A series of 25 women with genuine stress incontinence were treated by para-urethral injection of glutaraldehyde cross-linked collagen. The technique was simple and associated with few complications. Follow-up at 3 months revealed 20 patients (80%) to have been symptomatically improved or cured. An increase in urethral closure pressure together with a decrease in urine flow rate and increase in detrusor pressure was found post-operatively. The success rate was significantly higher (90%) in patients who had undergone previous surgery for urinary incontinence when compared with those who had had no previous surgery (73%).
authors.affiliation: Department of Urology, Southmead Hospital, Bristol.
authors.forename: S D
authors.initials: SD
authors.lastname: Eckford
authors.forename: P
authors.initials: P
authors.lastname: Abrams
mesh_terms: D000328:Adult; D000368:Aged; D003094:Collagen; D005260:Female; D006801:Humans; D007267:Injections; D008875:Middle Aged; D011184:Postoperative Period; D011312:Pressure; D016896:Treatment Outcome; D014521:Urethra / Q000503:physiopathology; D014550:Urinary Incontinence, Stress / Q000503:physiopathology / Q000628:therapy*; D014563:Urodynamics
chemical_list: C048470:glutaraldehyde-cross-linked collagen; D003094:Collagen