title: Effects of low concentrations of cyclopropane and halothane on peak velocity of saccadic eye movements.
abstract: We have investigated the effect of 4.7 and 8.8% MAC of cyclopropane, and 5.3 and 9.3% MAC of halothane on the peak velocity of saccadic eye movements (PSV) in six healthy volunteers. Both concentrations of cyclopropane and halothane significantly depressed PSV (P less than 0.01) compared with air, in a dose-related fashion. Halothane depressed PSV significantly more than cyclopropane (P less than 0.05). PSV returned to baseline within 5 min after discontinuation of the agents. There was no significant difference between cyclopropane, halothane and air in subjective assessment of sedation.
authors.affiliation: Department of Anaesthetics, University of Wales College of Medicine, Heath Park, Cardiff.
authors.forename: J
authors.initials: J
authors.lastname: Yoshizumi
authors.forename: R W
authors.initials: RW
authors.lastname: Marshall
authors.forename: M D
authors.initials: MD
authors.lastname: Vickers
mesh_terms: D000328:Adult; D000777:Anesthetics / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D003521:Cyclopropanes / Q000493:pharmacokinetics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006221:Halothane / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D011650:Pulmonary Alveoli / Q000378:metabolism; D012438:Saccades / Q000187:drug effects*
chemical_list: D000777:Anesthetics; D003521:Cyclopropanes; C030797:cyclopropane; D006221:Halothane