[Effects of oxymethacil on microcirculation and neuronal impulse activity in the cat cerebral cortex in acute fosfakol poisoning].
By using the methods of vital microscopy and extracellular registration of the neuronal activity the effect of oxymethacil (OM) on microcirculation and NSA in cat brain cortex was studied after grave poisoning by organophosphate paraoxon. The rapid depression of NSA together with the pronounced disturbances of microcirculation in cortical vessels were showed after intravenous injection of paraoxon (0.8 mg/kg). The prophylactic injection of OM (5 mg/kg) induced protective effect on the studied parameters. This effect was more pronounced when OM injection was combined with the M-cholinolytic amyzyl. The present data show the reasonableness of antioxidants using for the correction of a brain functional condition damaged by organophosphates.
Kamenev
A L
AL
Samoĭlov
M O
MO
Semenov
D G
DG
Sofronov
G A
GA
D000208:Acute Disease; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010261:Paraoxon / Q000008:administration & dosage / Q000506:poisoning*; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
D014498:Uracil; C003029:oxymethacil; D010261:Paraoxon
Vliianie oksimetatsila na mikrotsirkuliatsiiu i impul'snuiu aktivnost' neĭronov v kore bol'shogo mozga koshki pri ostrom otravlenii fosfakolom.