title: The response of cattle vaccinated with hypodermin A to a natural infestation of Hypoderma bovis and Hypoderma lineatum.
abstract: In this study, we have determined whether immunization with hypodermin A (HA), associated with various adjuvants, could provide protective immunity for calves when challenged with a natural hypoderma infestation. Groups of naive calves were vaccinated with HA antigen alone or with adjuvants [Freund's incomplete adjuvant (FIA) or alumina phosphate (AP)]. Subcutaneous injection with HA antigen with or without adjuvant did not significantly protect calves against a natural hypodermosis infestation. The humoral response during the infestation period was evaluated by ELISA. A significant earlier and greater response was induced in groups vaccinated with HA alone and HA combined with FIA. These results indicate that HA, in this vaccination protocol, induces a very incomplete protection in calves exposed to a natural infestation.
authors.affiliation: Laboratoire d'immunologie parasitaire, INRA, Monnaie, France.
authors.forename: N
authors.initials: N
authors.lastname: Chabaudie
authors.forename: C
authors.initials: C
authors.lastname: Villejoubert
authors.forename: C
authors.initials: C
authors.lastname: Boulard
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D005260:Female; D007000:Hypodermyiasis / Q000517:prevention & control / Q000662:veterinary*; D012697:Serine Endopeptidases / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*
chemical_list: D000276:Adjuvants, Immunologic; D012697:Serine Endopeptidases; C030092:hypodermin