title: Fifty years of amanitin.
abstract: Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far. The main toxin, alpha-amanitin, is in constant use as a tool in molecular biology and in biological research. First experiments have been reported in which amanitin bound to polymers could be internalized into tumor cells via a receptor-mediated endocytosis.
authors.affiliation: Max-Planck-Institut für Medizinische Forschung, Heidelberg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Wieland
authors.forename: H
authors.initials: H
authors.lastname: Faulstich
mesh_terms: D000546:Amanitins / Q000737:chemistry / Q000266:history* / Q000633:toxicity; D000818:Animals; D049673:History, 20th Century; D006801:Humans; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000633:toxicity; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000546:Amanitins; D010456:Peptides, Cyclic; D012319:RNA Polymerase II