title: Methicillin-resistant Staphylococcus aureus corneal ulcers.
abstract: Three patients with corneal ulcers had gram-positive cocci isolated on initial scrapings. There was no response to topical fortified aminoglycosides or cephalosporins. Cultures revealed methicillin-resistant Staphylococcus aureus that was sensitive only to topical vancomycin eye drops. Because the microbiologic spectrum is similar, vancomycin should be considered instead of a cephalosporin in the treatment of corneal ulcers to cover methicillin-resistant S. aureus and S. epidermidis.
authors.affiliation: Department of Ophthalmology & Visual Science, University of Louisville, Kentucky.
authors.forename: R A
authors.initials: RA
authors.lastname: Eiferman
authors.forename: K P
authors.initials: KP
authors.lastname: O'Neill
authors.forename: N A
authors.initials: NA
authors.lastname: Morrison
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003315:Cornea / Q000382:microbiology; D003320:Corneal Ulcer / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016106:Methicillin Resistance; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D014640:Vancomycin