[The roles of anesthetics and daily used drugs in cardiovascular changes during normovolemic hemodilution (NVHD)].
The changes of cardiovascular parameters and serum cathecholamine levels associated with normovolemic hemodilution (NVHD) were studied under three different conditions: Group 1; the patients for cardiac surgery who were taking cardiac drugs, and were anesthetized with fentanyl 30 micrograms.kg-1, Group 2; the patients with no-cardiac disease and taking no drugs, who were anesthetized with fentanyl 30 micrograms.kg-1 and Group 3; the patients with no-cardiac disease and taking no drugs, who were anesthetized with 0.75% halothane. Cardiac function was compared among three groups. After NVHD, blood pressure and heart rate of group 3 were significantly higher than those of group 1 and 2. Moreover, serum epinephrine and norepinephrine were elevated significantly after NVHD in only group 3. From this study, we conclude that, (1) daily used drugs do not predict hypotension during NVHD, and (2) high dose fentanyl anesthesia is associated with hypotension during NVHD.
Fujita
S
S
Department of Anesthesia, Asahikawa City General Hospital.
Sato
Y
Y
Okamoto
T
T
Koide
A
A
Mayumi
T
T
Maekawa
I
I
D002317:Cardiovascular Agents / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood; D005283:Fentanyl; D006221:Halothane; D006438:Hemodilution; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D009638:Norepinephrine / Q000097:blood
D002317:Cardiovascular Agents; D005283:Fentanyl; D006221:Halothane; D009638:Norepinephrine; D004837:Epinephrine