[Haemorheological observation during the process of tumor development after subcutaneous transplantation of non-metastatic mouse lung adenocarcinoma P615].
The haemorheological changes during tumor development in mice with transplanted non-metastatic lung adenocarcinoma (P615) were studied. The tumor cells were injected subcutaneously into 615-strain inbred mice. Animals were sacrificed at days 5, 10, 20, 30 and 35. Each mouse was examined histologically and by haemorheological tests, including plasma viscosity, blood viscosity, haematocrit and aggregation of erythrocytes. The development of subcutaneous tumor was divided into 4 stages after transplantation according to the histological changes, namely, latent stage, proliferative stage, stage of cyst-formation and stage with central necrosis. The haemorheological investigation showed that, compared with the normal animals, plasma viscosity was elevated on days 5, 10, 20, and 35, but was normal at on days 30. The aggregation of erythrocytes showed no change in the whole process of tumor development. The haematocrit and blood viscosity decreased on days 30 and 35 (stage with central necrosis). The significance of the results were discussed.
Xue
K X
KX
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing.
D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology; D000818:Animals; D001809:Blood Viscosity; D004903:Erythrocyte Aggregation; D005260:Female; D006400:Hematocrit; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D051379:Mice; D009367:Neoplasm Staging; D009368:Neoplasm Transplantation