3-Aminorhodanine and 2-hydrazino-2-imidazo-line hydrazones. Synthesis and antiparasitic pharmacology.
Two series of hydrazones were prepared by condensation of various aldehydes with 2-aminorhodanine (series 1) and 2-hydrazino-2-imidazoline (series 2). These compounds showed interesting antiparasitic activities against amoeba, trichomonas, leishmania and plasmodium.
Madadi
N E
NE
Laboratoire de Chimie Organique, Faculté de Pharmacie de Marseille.
Vanelle
P
P
Maldonado
J
J
Tedlaouti
F
F
Majester
B
B
Gasquet
M
M
Delmas
F
F
Timon-David
P
P
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D056890:Eukaryota / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D012236:Rhodanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000981:Antiprotozoal Agents; D006835:Hydrazones; D007093:Imidazoles; C072181:3-aminorhodanine; D012236:Rhodanine