title: D-- and Dc- gene complexes in the coloureds and blacks of Natal and the eastern Cape and blood group phenotype and gene frequency studies in the Natal coloured population.
abstract: Following the detection of apparent exclusions in the Rh system in two Coloured (mixed race) families during paternity testing, a rare D-- gene complex was identified in one family and two examples of an unusual gene complex producing weak e and very weak or non-demonstrable f antigen in the other. The latter, which almost certainly belong to the heterogeneous collection known as Dc-, were found when the Rh phenotypes expected to give f+, instead gave f- or f+W (weak positive) results and those expected to give f-, gave f+W results. Blood group phenotype and gene frequency studies showed that the Natal Coloured population contains a mixture of approximately 40% Black, 30% White and 30% Indian (Asian) genes. The phenotypes A1 high H, B high H, B low H, K+ and Kp(a+) associated with Caucasoids and the phenotypes Abantu, Dantu+, hrS- (Rh: -18,-19), hrB- (Rh: -31,-34) and Fy(a-b-) associated with Negroids were all represented. The DCe/Dc- frequency was 6.9% and the DcE/Dc- frequency 2.6%.
authors.affiliation: Natal Blood Transfusion Service, Durban, South Africa.
authors.forename: P
authors.initials: P
authors.lastname: Moores
authors.forename: U
authors.initials: U
authors.lastname: Vaaja
authors.forename: E
authors.initials: E
authors.lastname: Smart
mesh_terms: D044383:Black People / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D006801:Humans; D010334:Paternity; D010375:Pedigree; D010641:Phenotype; D012204:Rh-Hr Blood-Group System / Q000235:genetics*; D013019:South Africa / Q000208:ethnology
chemical_list: D012204:Rh-Hr Blood-Group System