title: [The effect of mildronate on carnitine-dependent and carnitine-independent ketogenesis in rats].
abstract: Mildronate of 3-(2,2,2-trimethylhydrozinium)propionate, a novel anti-ischemic drug, inhibits the biosynthesis of carnitine from Y-butyrobetaine. Continuous administration of mildronate (200, 400 mg/kg for 10 days orally) to rats exerted a marked antiketogenic action on the animals deprived of food for 48 hours. In the fed rats receiving sodium octanoate a course treatment with mildronate elevated to concentration of ketone bodies in blood serum. Selective regulation of carnitine-independent and carnitine-dependent metabolism appears justified for the treatment of such pathological states as ischemic heart disease, diabetes and obesity.
authors.forename: B Z
authors.initials: BZ
authors.lastname: Simkhovich
authors.forename: D V
authors.initials: DV
authors.lastname: Meĭrena
authors.forename: Kh B
authors.initials: KhB
authors.lastname: Khagi
authors.forename: Zh V
authors.initials: ZhV
authors.lastname: Shutenko
authors.forename: T N
authors.initials: TN
authors.lastname: Molodchina
authors.forename: I Ia
authors.initials: IIa
authors.lastname: Kalvin'sh
authors.forename: E Ia
authors.initials: EIa
authors.lastname: Lukevits
mesh_terms: D020155:3-Hydroxybutyric Acid; D000818:Animals; D002331:Carnitine / Q000037:antagonists & inhibitors* / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005215:Fasting / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006885:Hydroxybutyrates / Q000097:blood; D007657:Ketone Bodies / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D051381:Rats
chemical_list: D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate; D002331:Carnitine; D020155:3-Hydroxybutyric Acid
vernacular_title: Vliianie mildronata na karnitinzavisimyĭ i karnitinnezavisimyĭ ketogenez u krys.