A comparison of the single-dose effects of alprazolam, buspirone, and placebo upon memory function.
The effects of alprazolam and buspirone at varying dosages were compared with placebo in a battery of memory and cognitive tests in a sample of 125 young, healthy medical students by utilizing a single-dose, double-blind design. Although the dosages in this study did not impair visuomotor reaction time in any of the experimental groups, 1.0 mg of alprazolam did result in significantly impaired performance on selective aspects of memory function as assessed by the memory battery.
Barbee
J G
JG
Department of Psychiatry, Louisiana State University School of Medicine, New Orleans 70112.
Black
F W
FW
Kehoe
C E
CE
Todorov
A A
AA
D000328:Adult; D000525:Alprazolam / Q000494:pharmacology*; D001288:Attention / Q000187:drug effects; D002065:Buspirone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D009483:Neuropsychological Tests; D010153:Paired-Associate Learning / Q000187:drug effects; D010364:Pattern Recognition, Visual / Q000187:drug effects; D012153:Retention, Psychology / Q000187:drug effects*; D012691:Serial Learning / Q000187:drug effects; D014706:Verbal Learning / Q000187:drug effects
D002065:Buspirone; D000525:Alprazolam