title: Improved biocompatibility of extracorporeal circulation by the use of auto-oxygenation instead of artificial oxygenator in perfusion circuit.
abstract: The aim of this study was to determine the biocompatibility of an auto-oxygenation technique of cardiopulmonary bypass. Forty patients undergoing coronary bypass surgery were studied in two groups: A (auto-oxygenation, patients' lungs used in cardiopulmonary bypass) and B (conventional technique of cardiopulmonary bypass with bubble oxygenator). The platelet count decreased to -73% of initial value in group B vs only -27% in group A, P less than 0.001. Platelet aggregation to ADP decreased slightly in group A and hardly at all in group B, P less than 0.001. A transpulmonary leukocyte sequestration was greater in group B: 1.46 +/- 0.5 x 10(3)/mm3 vs only 0.34 +/- 0.2 x 10(3)/mm3 in group A, P less than 0.001. The level of C3a increased in group A from 244 +/- 46 ng/ml to 418 +/- 34 ng/ml and in group B from 268 +/- 46 ng/ml to 521 +/- 65 ng/ml, P less than 0.001, but in group A the levels were significantly less, P less than 0.001. The current study clearly confirms the superior biocompatibility of cardiopulmonary bypass with lung over oxygenator.
authors.affiliation: Cardiothoracic Surgery Department, Silesian Heart Center, Katowice, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Bochenek
authors.forename: Z
authors.initials: Z
authors.lastname: Religa
authors.forename: R
authors.initials: R
authors.lastname: Kustosz
authors.forename: A M
authors.initials: AM
authors.lastname: Wnuk-Wojnar
authors.forename: R
authors.initials: R
authors.lastname: Wnuk
authors.forename: J
authors.initials: J
authors.lastname: Wojnar
authors.forename: S
authors.initials: S
authors.lastname: Woś
authors.forename: M
authors.initials: M
authors.lastname: Wites
authors.forename: M
authors.initials: M
authors.lastname: Zembala
authors.forename: T
authors.initials: T
authors.lastname: Spyt
mesh_terms: D001672:Biocompatible Materials; D001760:Bleeding Time; D001792:Blood Platelets / Q000502:physiology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods; D003167:Complement Activation; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000379:methods*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008422:Materials Testing; D008875:Middle Aged; D010106:Oxygenators; D010976:Platelet Count
chemical_list: D001672:Biocompatible Materials; D006454:Hemoglobins