[Effect of biguanide derivatives on the indicators of lipid metabolism and the functional state of blood mononuclear cells in patients with insulin-dependent diabetes mellitus].
The paper provides the biochemical and immunological findings from 287 patients with Type I diabetes mellitus with regard to the pattern of their management. It has been shown that the patients treated with non-physiological large-dose insulin more frequently display clinical signs of atherosclerosis profound changes in the serum lipid profile and some immunological parameters. It is concluded that chronic insulin overdosage may play a role in the mechanisms of atherosclerosis development. It is indicated that the use of biguanidine derivatives in the treatment of patients with Type I diabetes mellitus concurrent with insulin overdosage leads to correction of most unfavorable changes in biochemical and immunological parameters.
Krasil'nikova
E I
EI
Blagosklonnaia
Ia V
IaV
Almazov
V A
VA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000139:chemically induced / Q000517:prevention & control*; D001645:Biguanides / Q000008:administration & dosage* / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced / Q000517:prevention & control*; D000960:Hypolipidemic Agents; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood; D007329:Insulin Antagonists; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*
D001645:Biguanides; D000960:Hypolipidemic Agents; D007328:Insulin; D007329:Insulin Antagonists; D008055:Lipids
Vliianie proizvodnykh biguanidov na pokazateli lipidnogo obmena i funktsional'noe sostoianie mononuklearov krovi u bol'nykh insulinozavisimym sakharnym diabetom.