title: Homogeneous 5-HT1D recognition sites in the human substantia nigra identified with a new iodinated radioligand.
abstract: The novel iodinated radioligand, serotonin-5-O-carboxymethyl-glycyl[125I] tyrosinamide, was used for binding studies with membranes of human substantia nigra. Evidence is provided for the existence in this tissue of a homogeneous population of recognition sites with the pharmacological profile of the 5-HT1D site.
authors.affiliation: Sandoz Pharma Ltd., Basel, Switzerland.
authors.forename: A T
authors.initials: AT
authors.lastname: Bruinvels
authors.forename: B
authors.initials: B
authors.lastname: Landwehrmeyer
authors.forename: C
authors.initials: C
authors.lastname: Waeber
authors.forename: J M
authors.initials: JM
authors.lastname: Palacios
authors.forename: D
authors.initials: D
authors.lastname: Hoyer
mesh_terms: D004151:Dipeptides; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000031:analogs & derivatives*; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism*
chemical_list: D004151:Dipeptides; D007457:Iodine Radioisotopes; D011985:Receptors, Serotonin; C072128:serotonin-O-carboxymethyl-Gly-Tyr; D012701:Serotonin