Comparison of the metabolism of four sulphonamides between humans and pigs.
Pigs are unable to form N1-glucuronides of sulphadimethoxine and sulphamethomidine, while humans are able to do so. Pigs and humans are able to oxidise sulphapyridine and form the O-glucuronide. The double conjugate N4-acetylsulphapyridine-O-glucuronide is formed in humans but not in pigs. Sulphadiazine is mainly acetylated in both humans and pigs. A hypothesis about N1-glucuronidation is presented.
Vree
T B
TB
Department of Clinical Pharmacy, Academic Hospital Nijmegen Sint Radboud, The Netherlands.
Beneken Kolmer
E W
EW
Peeters
A
A
D000107:Acetylation; D000818:Animals; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D006801:Humans; D006900:Hydroxylation; D010084:Oxidation-Reduction; D013411:Sulfadiazine / Q000493:pharmacokinetics; D013412:Sulfadimethoxine / Q000493:pharmacokinetics; D013424:Sulfanilamides / Q000493:pharmacokinetics; D013427:Sulfapyridine / Q000493:pharmacokinetics; D013449:Sulfonamides / Q000493:pharmacokinetics*; D013552:Swine / Q000378:metabolism*
D005965:Glucuronates; D013424:Sulfanilamides; D013449:Sulfonamides; D013411:Sulfadiazine; D013412:Sulfadimethoxine; C043086:sulfamethomidine; D013427:Sulfapyridine