Cephalosporins--cefotaxime 10 years later, a major drug with continued use.
Cefotaxime has in the past decade proved to be a most useful agent. It has established the efficacy and safety suggested in the early in vitro, pharmacological and clinical papers. It remains an excellent agent to treat many community and hospital-acquired respiratory infections, urinary tract infections, meningitis, particularly in pediatrics, spontaneous bacterial peritonitis and selected abdominal and gynecological infections.
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Division of Infectious Diseases, College of Physicians & Surgeons, New York, New York 10032.
D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control; D002439:Cefotaxime / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D002511:Cephalosporins / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008826:Microbial Sensitivity Tests; D013997:Time Factors; D001618:beta-Lactamases / Q000378:metabolism
D002511:Cephalosporins; D001618:beta-Lactamases; D002439:Cefotaxime