title: Fluoroacetate and fluorocitrate: mechanism of action.
abstract: The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a "suicide" substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glial-neuronal relationships is considered.
authors.affiliation: Department of Chemistry, Fordham University, Bronx, NY 10458.
authors.forename: D D
authors.initials: DD
authors.lastname: Clarke
mesh_terms: D000154:Aconitate Hydratase / Q000378:metabolism*; D000818:Animals; D002951:Citrates / Q000633:toxicity*; D005463:Fluoroacetates / Q000378:metabolism*; D009457:Neuroglia / Q000187:drug effects; D009474:Neurons / Q000187:drug effects
chemical_list: D002951:Citrates; D005463:Fluoroacetates; C007744:fluorocitrate; D000154:Aconitate Hydratase