Concentration of timolol in aqueous humour.
Two groups of twenty patients who were to undergo a routine e.c.c.e. applied eye-drops containing timolol 0.1% or 0.5% twice daily during the week preceding their operation. A third group of twenty patients, using placebo drops, served as control. During the cataract surgery a sample of aqueous was collected. The samples from the timolol 0.1% patient group contained a significantly lower concentration of timolol than those from the timolol 0.5% patient group, but there was considerable overlap.
Blanksma
L J
LJ
Department of Ophthalmology, University of Groningen, The Netherlands.
D000287:Administration, Topical; D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D002851:Chromatography, High Pressure Liquid; D003315:Cornea / Q000378:metabolism; D004304:Dosage Forms; D005260:Female; D006801:Humans; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013999:Timolol / Q000493:pharmacokinetics*
D004304:Dosage Forms; D013999:Timolol