Development of acute morphine tolerance in peripheral clinico-chemical parameters.
Changes in peripheral clinico-chemical parameters packed cell volume (PCV), hemoglobin (HGB), serum glucose, carbamide-nitrogen (CN), and creatinine were investigated in mice during the development of acute morphine tolerance. Acute morphine treatment (in drug-naive organism) altered the PCV, HGB, serum glucose and CN levels in a naloxone-reversible manner. Acute tolerance developed in PCV, HGB and CN values. The data raise the possibility of a relationship between clinico-chemical and pharmacological tolerance.
Héber
S
S
Central Laboratory, Markusovszky Teaching Hospital, Szombathely, Hungary.
Markó
E
E
Kovács
G L
GL
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D002241:Carbohydrates / Q000097:blood; D003404:Creatinine / Q000097:blood; D004361:Drug Tolerance; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology*; D009584:Nitrogen / Q000097:blood
D001786:Blood Glucose; D001798:Blood Proteins; D002241:Carbohydrates; D006454:Hemoglobins; D009020:Morphine; D003404:Creatinine; D009584:Nitrogen