title: Gentamicin-collagen sponge for local applications. 10 cases of chronic osteomyelitis followed for 1 year.
abstract: A bovine collagen sponge containing gentamicin was applied locally in 10 patients with chronic osteomyelitis who were then followed for 1 year postoperatively. No adverse effects or recurrence of infections was observed. The release of gentamicin from the sponge was more complete and rapid than has been reported with polymethyl methacrylate (PMMA) beads. Compared with previous reports on PMMA beads, a much higher gentamicin concentration in the wound exudate can be expected after implantation of the collagen sponge, which is easy to apply and does not require a second operation for removal.
authors.affiliation: University Department of Orthopedics, Odense, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Ipsen
authors.forename: P S
authors.initials: PS
authors.lastname: Jørgensen
authors.forename: V
authors.initials: V
authors.lastname: Damholt
authors.forename: C
authors.initials: C
authors.lastname: Tørholm
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D003094:Collagen; D004337:Drug Carriers; D005260:Female; D005500:Follow-Up Studies; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy* / Q000503:physiopathology; D011446:Prospective Studies; D014945:Wound Healing / Q000187:drug effects
chemical_list: D004337:Drug Carriers; D005839:Gentamicins; D003094:Collagen