title: [Non-steroidal anti-inflammatory agents. XXII. Chiral aryl-hydroxy-fluorenylpropionic acids].
abstract: As fluorenyl rigid analogues of previous biphenylyl alcanoic acids with very interesting antiinflammatory activity, the 3-(m-tolyl and m-anisyl)-3-hydroxy-3-(2-fluorenyl)-propionic acids have been prepared by means of the Reformatsky reaction and following hydrolysis of the obtained ethyl esters. The preliminary antiinflammatory assay showed that the structural modification inactivates the compounds.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Bologna.
authors.forename: S
authors.initials: S
authors.lastname: Burnelli
authors.forename: L
authors.initials: L
authors.lastname: Varoli
authors.forename: A
authors.initials: A
authors.lastname: Guarnieri
authors.forename: B
authors.initials: B
authors.lastname: Lumachi
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan / Q000037:antagonists & inhibitors; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005449:Fluorenes / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005449:Fluorenes; D002351:Carrageenan
vernacular_title: Antiinfiammatori non steroidei. XXII--Acidi aril-idrossi-fluorenilpropionici chirali.