Inhibition of apomorphine-induced yawning and penile erection by neurotensin.
The yawns and penile erection elicited in rats by apomorphine (100 micrograms/kg SC) are dose-dependently suppressed by the enkephalinase-resistant analog of NT, [D-Trp11]NT, intracerebroventricularly (ICV) injected (10-120 ng per rat). This antagonistic effect was shared by NT (0.75-3 micrograms per rat) administered ICV. The yawns induced by pilocarpine (2 mg/kg IP) were similarly antagonized by [D-Trp11]NT (30-120 ng per rat). The enkephalinase inhibitor acetorphan (5 mg/kg IV) reduced in a naloxone (2 mg/kg, SC)-resistant manner the apomorphine-induced penile erection or yawning.
Nouel
D
D
European Institute for Peptide Research, Unité de Neuropsychopharmacologie Expérimentale U.R.A. 1170 du C.N.R.S., Faculté de Médecine et Pharmacie de Rouen, Saint Etienne Du Rouvray, France.
Costentin
J
J
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004336:Drug Antagonism; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D015260:Neprilysin / Q000037:antagonists & inhibitors / Q000378:metabolism; D009496:Neurotensin / Q000494:pharmacology*; D010410:Penile Erection / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D015244:Thiorphan / Q000031:analogs & derivatives / Q000494:pharmacology; D015000:Yawning / Q000187:drug effects*
D009270:Naloxone; D009496:Neurotensin; C049331:racecadotril; D015244:Thiorphan; D015260:Neprilysin; D001058:Apomorphine