title: Effects of laminin on functional reinnervation of target organs by regenerating axons.
abstract: Reinnervation of sweat glands, skeletal muscle and skin was studied in the mouse paw after section of the sciatic nerve and repair by entubulation with collagen conduits, with and without a coating of laminin. After operation, sweat glands activated by pilocarpine reappeared at 32 days and increased in number to 67% of control counts. Muscle action potentials (during sciatic nerve stimulation) were recorded from the interosseus muscle at 39 days. The potential amplitudes increased to 30% of controls. The first withdrawal response from pin prick to the paw was observed at about 34 days, the response score increasing to 66% of control. There were no significant differences at any test interval between the control group and the group with laminin added.
authors.affiliation: Department of Neurology, University of Minnesota, Minneapolis 55455.
authors.forename: X
authors.initials: X
authors.lastname: Navarro
authors.forename: W R
authors.initials: WR
authors.lastname: Kennedy
authors.forename: N J
authors.initials: NJ
authors.lastname: Stewart
authors.forename: L T
authors.initials: LT
authors.lastname: Furcht
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D003714:Denervation; D004594:Electrophysiology; D005528:Foot; D007797:Laminin / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000294:innervation / Q000502:physiology; D009416:Nerve Regeneration / Q000187:drug effects*; D012584:Sciatic Nerve / Q000502:physiology; D012677:Sensation / Q000502:physiology; D012867:Skin / Q000294:innervation; D013545:Sweat Glands / Q000294:innervation / Q000378:metabolism
chemical_list: D007797:Laminin