title: Transforming activity of ethylene dibromide in BALB/c 3T3 cells.
abstract: Ethylene dibromide was capable of inducing in vitro transformation of BALB/c 3T3 cells either in the presence or in the absence of exogenous metabolic activation (S9-mix). This transforming effect was evidenced by the induction of a higher number of transformed foci as compared to the controls performed with untreated cells or solvent vehicle-treated cells. In the absence of exogenous activation, all assayed doses (ranging from 23.4 micrograms/ml to 187.9 micrograms/ml) exerted transforming activity. Number of foci obtained in EDB-treated plates antransformation frequency of the target cells were higher than those detected in the transformation test performed in the presence of S9-mix.
authors.affiliation: Centro Interuniversitario per la Ricerca sul Cancro, Universita' di Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Perocco
authors.forename: A
authors.initials: A
authors.lastname: Colacci
authors.forename: M A
authors.initials: MA
authors.lastname: Santucci
authors.forename: M
authors.initials: M
authors.lastname: Vaccari
authors.forename: S
authors.initials: S
authors.lastname: Grilli
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity; D001711:Biotransformation; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D015946:Ethylene Dibromide / Q000493:pharmacokinetics / Q000633:toxicity*; D008748:Methylcholanthrene / Q000633:toxicity; D051379:Mice
chemical_list: D015946:Ethylene Dibromide; D001564:Benzo(a)pyrene; D008748:Methylcholanthrene