title: The effect of in vitro irradiation on human NK cell activity. A preliminary report.
abstract: Natural killer activity of peripheral blood cells was evaluated after in vitro irradiation at doses ranging between 100 and 1600 cGy. Natural killer (NK) cells from normal donors exhibited a trend towards increased cytotoxicity peaking at about 600 cGy and then gradually decreasing. NK cells isolated from peripheral blood of cancer patients showed a lower baseline of activity, which was less affected by the same doses of in vitro irradiation. A distinction could be made between patients with early disease and those with advanced cancers; patients with early cancers showing NK activity close to that of normal donors.
authors.affiliation: Department of Oncology, Rambam Medical Center, Haifa, Israel.
authors.forename: J N
authors.initials: JN
authors.lastname: Halpern
authors.forename: E
authors.initials: E
authors.lastname: Cohen
authors.forename: T
authors.initials: T
authors.lastname: Mekori
authors.forename: A N
authors.initials: AN
authors.lastname: Beny
authors.forename: A
authors.initials: A
authors.lastname: Kuten
authors.forename: E A
authors.initials: EA
authors.lastname: Rosenblatt
authors.forename: E
authors.initials: E
authors.lastname: Robinson
mesh_terms: D000208:Acute Disease; D006801:Humans; D007111:Immunity, Cellular / Q000528:radiation effects; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000528:radiation effects*; D007951:Leukemia, Myeloid / Q000097:blood; D014407:Tumor Cells, Cultured / Q000528:radiation effects