title: New trends in chloroquine efficacy in the treatment of malaria: chloroquine-resistant Plasmodium falciparum in Anambra and Benue States of Nigeria.
abstract: Increasing malaria treatment failures with chloroquine (C25) and reports of chloroquine resistant Plasmodium falciparum (CRPF) led to the field survey of two sites (Agbani and Jato-Aka) both in Primary Health Zone A, using WHO--in vivo seven-day test, modified to 14-day follow-up period. Of the 922 children studied, high transmission rates of 40 pc and 59.2 pc were found in Agbani and Jato-Aka respectively. Varying degrees of parasitologic failures (CRPF), 52 pc in Agbani and 60 pc in Jato-Aka were confirmed. However, chemotherapy with C25 significantly reduced the clinical symptoms of malaria infection, even in the CRPF-cases. The clinical success in the two study sites were 69 pc ad 94 pc respectively.
authors.affiliation: Department of Medicine, College of Medical Sciences, University of Calabar, Nigeria.
authors.forename: E N
authors.initials: EN
authors.lastname: Ezedinachi
authors.forename: G C
authors.initials: GC
authors.lastname: Ejezie
authors.forename: E A
authors.initials: EA
authors.lastname: Usanga
authors.forename: E I
authors.initials: EI
authors.lastname: Gemade
authors.forename: N W
authors.initials: NW
authors.lastname: Ikpatt
authors.forename: A A
authors.initials: AA
authors.lastname: Alaribe
mesh_terms: D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology / Q000635:transmission; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D011159:Population Surveillance; D015995:Prevalence; D012424:Rural Population
chemical_list: D002738:Chloroquine