Influence of dimethoate on testicular and epididymal organs, testosterone plasma level and their tissue residues in rats.
The effect of dimethoate at two dosage levels (6.25 and 12.50 mg/kg b. wt.) on male reproduction tissues and their tissue residues in rats were studied. The tested doses were given orally to male rats for 65 consecutive days. Sex organs weight analysis, semen picture, testosterone levels and histopathology of the male genital organs were the criteria used to evaluate the reproductive efficiency of the treated rats. There was a dose-related decrease in the weights of most genital organs and sperm motility associated with an increase in the percentages of dead and morphologically abnormal spermatozoa of treated rats. A decrease in plasma testosterone levels was observed in the treated groups. Histological examination revealed that dimethoate caused testicular lesions characterized by moderate to severe degenerative changes of spermatogonial cells and by partial arrest of spermatogenesis. Sections from liver revealed that the central veins and hepatic sinusoids appeared dilated, with some areas of haemorrhage. The highest concentrations from dimethoate were found in liver and tests and the lowest in skeletal muscle. Dimethoate and its metabolite analog were still present in a detectable concentration 21 days after stopping its oral administration.
Afifi
N A
NA
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Ramadan
A
A
el-Aziz
M I
MI
Saki
E E
EE
D000818:Animals; D004117:Dimethoate / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D004350:Drug Residues / Q000032:analysis*; D004822:Epididymis / Q000737:chemistry / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000737:chemistry / Q000187:drug effects*; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D004117:Dimethoate