Do 15-lipoxygenases have a common biological role?
In contrast to the well-studied role of 5-lipoxygenase in the arachidonic acid cascade that occurs in inflammatory cells, the biological role of the related 15-lipoxygenases in the metabolism of free polyenoic fatty acids is far from clear. However, the activity of 15-lipoxygenases with more complex substrates may play a crucial role in the differentiation and maturation of certain cell types and in the oxidative modification of lipoproteins in the early stages of atherosclerosis.
Schewe
T
T
Institute of Biochemistry, Medical School (Charité), Humboldt-University, Berlin, FRG.
Kühn
H
H
D000818:Animals; D001093:Arachidonate 15-Lipoxygenase / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008928:Mitochondria / Q000201:enzymology; D012156:Reticulocytes / Q000201:enzymology
D005227:Fatty Acids; D001093:Arachidonate 15-Lipoxygenase