Insulin-dependent diabetes mellitus.
Type I diabetes occurs as a result of T-cell-mediated beta-cell destruction. Several candidate antigens have been described recently, including glutamic acid decarboxylase, heat shock protein 65 and peripherin. Restricted T-cell receptor V beta gene usage in non-obese diabetic mice has been suggested but not yet proven. In addition to major histocompatibility genes, several non-H-2 predisposing genes have been mapped on chromosomes 1, 3 and 11.
Bach
J F
JF
Hôpital Neckar, Paris, France.
D001324:Autoantigens / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D008285:Major Histocompatibility Complex; D013601:T-Lymphocytes / Q000276:immunology
D001324:Autoantigens