[Neuropharmacological activity of cerucal and haloperidol by intraperitoneal and intrastriatal administration in rats].
The effects of three-week administration of cerucal and haloperidol were compared in two ways of injections--intraperitoneal 10 mg/kg and intrastriatal 5 micrograms/l microliter. Both of the ways produce the inhibition of rats locomotor activity, but only after the intraperitoneal haloperidol injection the cataleptic status was observed. The inhibition of avoidance conditioning in shuttle box was registered in each haloperidol microinjections, but in case of cerucal intrastriatal microinjection this effect in first 4-5 days of experiment was limited. No any muscular deviation after cerucal injection (systemic and intrabrain) were observed. The antihyperkinetic activity and striatal mechanisms of cerucal and their application in neurology were discussed.
Iakimovskiĭ
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AF
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002375:Catalepsy; D003342:Corpus Striatum; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D007274:Injections, Intraperitoneal; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D006220:Haloperidol; D008787:Metoclopramide
Neĭrofarmakologicheskaia aktivnost' tserukala i galoperidola pri vnutribriushinnom i vnutristriarnom vvedenii krysam.