[Platelet aggregation with SIN 1: comparison with isosorbide-5-mononitrate and acetylsalicylic acid].
SIN 1, the bioactive metabolite of molsidomine, not only appears to lack the problem of inducing nitrate tolerance, but also exerts antiaggregatory and fibrinolytic properties. These effects, which either are not or only in part shared by the drug isosorbide-5-mononitrate, might be beneficial in the prevention of thromboembolic complications in cardiovascular disease. In contrast to the effects of acetylsalicylic acid, SIN 1 already inhibits aggregation during the first phase of aggregation, and it inhibits aggregations induced by agonists that are not or only marginally influenced by acetylsalicylic acid (such as the aggregation induced by platelet activating factor). Thus, the antiaggregatory effects of molsidomine cannot replace the effects of acetylsalicylic acid, while a combination of both drugs might be of benefit in the treatment of patients with cardiovascular disease.
Gerzer
R
R
Medizinische Klinik Klinikum Innenstadt der Universität München.
Karrenbrock
B
B
Niederreiter
B
B
Heim
J M
JM
Drummer
C
C
D001241:Aspirin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives* / Q000494:pharmacology; D008981:Molsidomine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; C002385:linsidomine; D008981:Molsidomine; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate; D001241:Aspirin
Thrombozytenaggregation unter SIN 1: Vergleich mit Isosorbid-5-mononitrat und Acetylsalizylsäure.