Development of radiolabelled albumin microspheres: a comparison of gamma-emitting radioisotopes of iodine (131I) and indium (111In/113mIn).
Biodegradable albumin microspheres have been prepared incorporating either 131I or 111In/111In. Using cDTPAA/albumin molar ratios of 1, 3 and 10, approx. 0.7, 2.1 and 7 molecules of DTPA could be coupled to an albumin molecule, labelling efficiency being constant over this range. Because 131I microspheres were more stable in plasma than the system labelled with radionuclides of indium it was selected for clinical evaluation: potential uses of this radiopharmaceutical are illustrated.
Willmott
N
N
Department of Pharmacy, University of Strathclyde, Glasgow, Scotland.
Murray
T
T
Carlton
R
R
Chen
Y
Y
Logan
H
H
McCurrach
G
G
Bessent
R G
RG
Goldberg
J A
JA
Anderson
J
J
McKillop
J H
JH
D001673:Biodegradation, Environmental; D002614:Chelating Agents; D004337:Drug Carriers; D006801:Humans; D007205:Indium Radioisotopes; D007553:Isotope Labeling; D008099:Liver / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008863:Microspheres; D004369:Pentetic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D011877:Radionuclide Imaging; D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated / Q000378:metabolism
D002614:Chelating Agents; D004337:Drug Carriers; D007205:Indium Radioisotopes; D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated; C039777:cyclic DTPA anhydride; D004369:Pentetic Acid