[Alterations of the aortic endothelium ultrastructure after the administration of cholesterol oxidation products to rabbits].
Intravenous administration of 7 alpha-hydroxycholesterol and cholestane-triol at the dose of 2.5 mg/kg produces, one day later, ultrastructural alteration of aortic endothelial cells such as cytoplasmic vacuolation, protruding and crateriform surface defects, subendothelial oedema with a subsequent exfoliation of endotheliocytes. The endothelial damage was more pronounced after the administration of equal doses of cholestane-triol as compared to 7 alpha-hydroxycholesterol. Ultrastructural changes 10 days after oral administration of 500 mg/kg cholesterol mixed with its auto-oxidation products were similar to those developing after cholestane-triol and 7 alpha-hydroxycholesterol. Cholesterol free of the oxidation products at the same doses did not produce alterations in the rabbit aortic endothelium.
Beskrovnova
N N
NN
Konovalova
G G
GG
Rudnik
V E
VE
Lankin
V Z
VZ
Vikhert
A M
AM
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000648:ultrastructure; D002777:Cholestanols / Q000494:pharmacology; D002784:Cholesterol / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000648:ultrastructure*; D006888:Hydroxycholesterols / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008297:Male; D010084:Oxidation-Reduction; D011817:Rabbits
D002777:Cholestanols; D006888:Hydroxycholesterols; D000960:Hypolipidemic Agents; C000474:cholestane-3,5,6-triol; C011724:cholest-5-en-3 beta,7 alpha-diol; D002784:Cholesterol
Izmenenie ul'trastruktury éndoteliia aorty pri vvedenii krolikam produktov okisleniia kholesterina.