Peripheral and renal vein renin activity in patients with renovascular hypertension due to nonspecific aortoarteritis.
The diagnostic utility of peripheral and renal vein renin estimations in relation to angiographic findings was evaluated in 13 patients with renovascular hypertension and non-specific aortoarteritis (NSAA, Gr I), in comparison with 10 patients with renal artery stenosis due to other causes (Gr II). Plasma renin activity (PRA) was measured by radioimmunoassay. Blood samples were collected after angiography from the femoral vein and renal vein on the affected side followed by sampling from the less affected or unaffected side. Renal vein renin ratio (RVRR) was calculated from renal vein renin values. The effect of captopril (25 mg oral) on blood pressure, PRA, and RVRR was examined in 8 patients from each group. Normotensive volunteers (8) with moderately low salt intake were also included in the study for comparison of twenty-four-hour urinary sodium output, peripheral PRA, and response to captopril. The mean peripheral PRA was high in both groups as compared with normotensive controls; however, the values were lower in patients with NSAA. The rise in PRA in response to captopril was insignificant in Gr I (p greater than 0.05) and RVRR greater than 1.5 was observed in 5 of 13 patients in contrast to 9 of 10 in Gr II (p less than 0.05). A paradoxical ratio, ie, (high renal vein renin levels on the less stenotic side) was noticed in 3 patients of Gr I, whereas none of the patients of GR II showed such a ratio. An improvement in RVRR after captopril was observed in 50% of patients of Gr I as compared with a marked response in all patients of Gr II.(ABSTRACT TRUNCATED AT 250 WORDS)
Lall
S B
SB
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
Dave
V
V
Dash
S C
SC
Bhargava
S
S
D000293:Adolescent; D000328:Adult; D001025:Aortitis / Q000097:blood* / Q000150:complications / Q000601:surgery; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D002648:Child; D005260:Female; D005268:Femoral Vein / Q000000981:diagnostic imaging; D006801:Humans; D006978:Hypertension, Renovascular / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography; D012078:Renal Artery Obstruction / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D012082:Renal Veins / Q000000981:diagnostic imaging; D012083:Renin / Q000097:blood* / Q000187:drug effects
D002216:Captopril; D012083:Renin