[The extractable calcitonin value in normal individuals].
Human calcitonin levels have been measured by many authors, however the limit of detectability of human calcitonin is as high as 10 pg/ml, and its normal value may range from 10 to 249 pg/ml. To avoid the limitations of present human calcitonin assays, Hunter Heath in 1983 developed a silica Sep-Pap extraction procedure. In this study, extractable calcitonin (Monomeric CT = CT-M) in 261 normal individuals was determined using Heath's method. The CT-M value ranged from 3.0 to 17.4 pg/ml with an average of 7.5 +/- 2.2 pg/ml. The limit of detectability of CT-M was 1.0 pg/ml. The CT-M value was higher in males than in females in all generations, and was highest in the third decade and slightly decreased in the seventh decade. CT-M seemed to accurately reflect human calcitonin in the pure form. The values of human calcitonin determined in this study may be useful in the clinical laboratory.
Mizohata
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Department of Orthopedic Surgery, Kyörin University, School of Medicine, Tokyo, Japan.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002116:Calcitonin / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D002116:Calcitonin