Ryanodyl 3-(pyridine-3-carboxylate): a novel ryanoid from Ryania insecticide.
Ryanodyl 3-(pyridine-3-carboxylate) was isolated as a minor component from the wet CHCl3 extract of Ryania insecticide, and its structure was assigned by chemical and spectroscopic methods. This compound is essentially inactive compared with ryanodine for insecticidal activity against Musca domestica adults and Tribolium castaneum larvae, for toxicity to mice, and for competition with [3H]ryanodine at the Ca(2+)-ryanodine receptor complex of skeletal muscle.
Jefferies
P R
PR
Department of Entomological Sciences, University of California, Berkeley 94720.
Toia
R F
RF
Casida
J E
JE
D000818:Animals; D006793:Houseflies; D007306:Insecticides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009539:Nicotinic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D012433:Ryanodine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D014231:Tribolium
D007306:Insecticides; D009539:Nicotinic Acids; C073089:ryanodyl 3-(pyridine-3-carboxylate); D012433:Ryanodine