In vivo boron-11 MRI and MRS using (B24H22S2)4- in the rat.
In vivo boron-11 magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) were performed on a rat that had been infused with a potential boron neutron capture therapy agent, Na4B24H22S2, using methods for detecting nuclei with a short T2 relaxation time. MRI and MRS were also performed on a euthanized rat that had been similarly infused in vivo. Boron-11 spectral intensities decreased in the living rat over a 25-h period. The results demonstrate the capability of MRI and MRS to noninvasively monitor the distribution and excretion of boron agents in vivo.
Kabalka
G W
GW
Department of Radiology, University of Tennessee Biomedical Imaging Center, Knoxville 37920.
Cheng
G Q
GQ
Bendel
P
P
Micca
P L
PL
Slatkin
D N
DN
D000818:Animals; D001895:Boron; D004220:Disulfides; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D009502:Neutrons; D051381:Rats; D011916:Rats, Inbred F344
D004220:Disulfides; D001895:Boron