title: Anti-infective therapy in intensive care units.
abstract: In intensive care units, treatment is primarily directed at the suspected pathogen. However, the risk of interaction with other concomitantly administered drugs, the possible accumulation when renal and, in particular, hepatic function are impaired, and the possible development of resistance play major roles when selecting a therapeutic regimen. Studies of interactions between the different antimicrobial substances and, in particular, interactions between the antibiotics and other drugs are urgently called for in the future.
authors.affiliation: Klinikum der J.-W.-Goethe-Universität, Zentrum der Inneren Medizin/Infektiologie, Frankfurt am Main, Germany.
authors.forename: P M
authors.initials: PM
authors.lastname: Shah
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control*; D002439:Cefotaxime / Q000627:therapeutic use; D015169:Colony Count, Microbial; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D006801:Humans; D007362:Intensive Care Units / Q000145:classification; D010362:Patients' Rooms; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D002439:Cefotaxime