Nodal spacing in the developing, young adult and aging rat inferior alveolar nerve.
This study examines the nodal spacing (L) in teased preparations of developing, young adult and aging rat inferior alveolar nerves. In nerves from rats aged 1-2 weeks, most internodes show L-values, which increase from 150 microns to 400 microns, as fiber diameter (D) increases. Other internodes are very short (L = 20-150 microns), and exhibit distorted or fragmented myelin sheaths. In nerves from 2-3 week old rats such very short internodes are rare. By 3-4 weeks, and in young adult animals, very short internodes are lacking. The young adult relation L/D is regular and rectilinear. While D ranges from 2 microns to 10 microns, L ranges from 200 microns to 700-800 microns. In nerves from 1-2.5 year old adult rats some internodes are greater than 1000 microns long. These old nerves show signs of of nodal widening and segmental de- and remyelination. Some newly formed internodes are very short. We suggest that the occurrence of very short internodes in the developing rat inferior alveolar nerve reflects a myelin sheath remodelling, that allows the growing sheaths to elongate more than the nerve. Similarly, a scattered segmental de- and remyelination or a contraction of some internodes might enable other internodes in the old adult IAN to elongate, although the animal is fully grown.
Hildebrand
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Department of Cell Biology, Faculty of Health Sciences, University of Linköping, Sweden.
Johansson
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CS
D000375:Aging / Q000502:physiology*; D000818:Animals; D005260:Female; D008297:Male; D008340:Mandibular Nerve / Q000033:anatomy & histology / Q000502:physiology*; D009186:Myelin Sheath / Q000502:physiology; D009420:Nervous System / Q000254:growth & development; D009473:Neuronal Plasticity; D011901:Ranvier's Nodes / Q000502:physiology*; D051381:Rats