Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig.
The interactions between LPS-induced bronchial hyper-reactivity (BHR) and lung inflammation (LI) were investigated. LPS-induced LI was assessed with the augmented alveolo-capillary permeability (ACP) and with the increased migration of neutrophils into the broncho-alveolar lavage fluid. BHR was defined as the increase in the response to a standard dose of serotonin. Mepyramine and the PAF antagonist WEB 2170 blocked LPS-induced increase of ACP, whereas aspirin was inactive. By contrast, neither LPS-induced neutrophil attraction to airways, nor LPS-induced HBR were inhibited by these agents. Our results indicate that LPS-induced edema and BHR are dissociated.
Vincent
D
D
Service de Médecine Interne, Hôpital Rothschild, Paris, France.
Lefort
J
J
Bureau
M
M
Dry
J
J
Vargaftig
B B
BB
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001381:Azepines / Q000494:pharmacology; D001982:Bronchial Diseases / Q000139:chemically induced* / Q000503:physiopathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D004926:Escherichia coli; D006168:Guinea Pigs; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000503:physiopathology; D011738:Pyrilamine / Q000494:pharmacology; D012130:Respiratory Hypersensitivity / Q000503:physiopathology*; D014230:Triazoles / Q000494:pharmacology
D001381:Azepines; D008070:Lipopolysaccharides; D010972:Platelet Activating Factor; D014230:Triazoles; C063964:bepafant; D011738:Pyrilamine; D001241:Aspirin