title: Detection of anti-ovarian antibodies by indirect immunofluorescence in patients with premature ovarian failure.
abstract: The sera of 30 patients with premature ovarian failure (POF) and a control group of 19 menopausal women were screened for anti-ovarian and other tissue antibodies. Anti-ovarian antibodies were detected by indirect immunofluorescence using monkey ovary substrates from two different commercial sources. Serum anti-ovarian antibodies were detected in only one of the patients with POF. This test does not appear to be reliable for the detection of serum anti-ovarian antibodies, and the clinical usefulness of screening patients with POF for anti-ovarian antibodies is questionable.
authors.affiliation: Department of Obstetrics and Gynaecology, Kolling Institute of Medical Research, St Leonards, NSW, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Kirsop
authors.forename: C R
authors.initials: CR
authors.lastname: Brock
authors.forename: B G
authors.initials: BG
authors.lastname: Robinson
authors.forename: R J
authors.initials: RJ
authors.lastname: Baber
authors.forename: J V
authors.initials: JV
authors.lastname: Wells
authors.forename: D M
authors.initials: DM
authors.lastname: Saunders
mesh_terms: D000311:Adrenal Glands / Q000276:immunology; D000328:Adult; D000906:Antibodies / Q000032:analysis*; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006386:Hemagglutination Tests; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000276:immunology*; D010295:Parietal Cells, Gastric / Q000276:immunology; D016649:Primary Ovarian Insufficiency / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology
chemical_list: D000906:Antibodies; D000974:Antibodies, Antinuclear