[Analysis of the effect of the alpha 1-adrenostimulator mezaton on plasma renin activity in healthy people of varying age].
30 healthy people aged 20-34, 60-74 and 75-89 (10 subjects in each group) were examined to study the changes in plasma renin activity (PRA), the sympathetic nervous system tone, indices of central and renal haemodynamics after intramuscular injections of alpha 1-adrenostimulator mezaton (phenylephrine) in dose of 0.15 mg/kg of body mass. The pharmacological activity of postsynaptic alpha 1-adrenoreceptors was found to induce more considerable and prolonged increase of PRA in older persons. The increase of PRA was reliably correlated with a decrease of renal blood flow indices and was combined with an increase of sympathetic tone. As to the authors' opinion a more pronounced constrictor response of afferent renal arterioles to alpha 1-adrenoreceptors activation of vessels is the cause of more considerable changes of PRA in older age groups.
Korkushko
O V
OV
Fedirko
M I
MI
Shatilo
V B
VB
Mistriukov
V M
VM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D010656:Phenylephrine / Q000494:pharmacology*; D012016:Reference Values; D012083:Renin / Q000097:blood*
D010656:Phenylephrine; D012083:Renin
Analiz vliianiia al'fa1-adrenostimuliatora mezatona na aktivnost' renina plazmy u zdorovykh liudeĭ raznogo vozrasta.