title: Human DBI (endozepine): relationship to a homologous membrane associated protein (MA-DBI).
abstract: Human endozepine, an 86 amino acid polypeptide, was originally isolated from human brain tissue as a putative ligand of the benzodiazepine receptor. Complete amino acid sequencing of the human and bovine proteins revealed significant homology with the partial sequence of diazepam binding inhibitor (DBI), a protein from rat brain. Both endozepine and DBI have been shown to elicit behavioral effects, suggesting that they function as pharmacologically-active ligands of the GABA (gamma-aminobutyric acid) receptor complex. Subsequent cDNA cloning of human and bovine endozepine, rat DBI and human DBI has shown that these proteins are encoded by the same gene. A related cDNA, encoding a transmembrane protein of 533 amino acids with a domain homologous to DBI, has also been cloned from bovine brain.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
authors.forename: G J
authors.initials: GJ
authors.lastname: Todaro
authors.forename: T M
authors.initials: TM
authors.lastname: Rose
authors.forename: M
authors.initials: M
authors.lastname: Shoyab
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D026261:Diazepam Binding Inhibitor; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008961:Models, Structural; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000235:genetics*; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid
chemical_list: D026261:Diazepam Binding Inhibitor; D008565:Membrane Proteins; D009479:Neuropeptides