Sorting of plasma membrane proteins in epithelial cells.
Proteins follow two routes to reach the correct surface (apical or basolateral) of a polarized epithelial cell: direct sorting from the trans-Golgi network and transcytosis from early endosomes. Several signals have been identified recently that control these sorting events, namely a glycosyl-phosphatidylinositol anchor for apical targeting, a 14-residue cytoplasmic segment of the polymeric immunoglobulin receptor for basolateral targeting, and phosphorylation of a Ser residue for transcytosis of this receptor. The machinery involved is still poorly understood.
Bomsel
M
M
CNRS, Paris, France.
Mostov
K
K
D000818:Animals; D001692:Biological Transport; D002451:Cell Compartmentation; D016764:Cell Polarity; D002478:Cells, Cultured; D004285:Dogs; D004705:Endocytosis; D004848:Epithelium / Q000378:metabolism* / Q000648:ultrastructure; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011971:Receptors, Immunologic; D012635:Secretory Component / Q000378:metabolism
D008565:Membrane Proteins; D011971:Receptors, Immunologic; D012635:Secretory Component; D020558:GTP Phosphohydrolases