166Holmium-containing glass for internal radiotherapy of tumors.
Aluminosilicate glass containing the beta-emitter 166Ho was tested for tumor cell killing effectiveness with the BT-20 human mammary carcinoma cell line as a model. Incubation of BT-20 cells with 166Ho glass partially inhibited DNA replication and completely blocked growth in cells located within 1.0 mm of the radioactive fiber. Growth of BT-20 tumor xenografts in nude mice was dramatically inhibited by injection of 2-5 microns fragments of 166Ho glass (200 microCi/tumor). The results suggest that 166Ho glass would be an effective modality for deposition of intense beta- radiation for localized internal radiotherapy of tumors.
Brown
R F
RF
Department of Life Sciences, University of Missouri-Rolla 65401.
Lindesmith
L C
LC
Day
D E
DE
D000818:Animals; D001918:Brachytherapy; D001943:Breast Neoplasms / Q000532:radiotherapy*; D002470:Cell Survival / Q000528:radiation effects; D004247:DNA / Q000378:metabolism; D005898:Glass; D006695:Holmium / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011868:Radioisotopes / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured
D011868:Radioisotopes; D004247:DNA; D006695:Holmium