title: Intrauterine treatment of thyroid goiters.
abstract: A fetal thyroid goiter detected by ultrasonography at 20 weeks of amenorrhea (WA) was diagnosed at 23 WA by a second ultrasound examination and a TSH assay in amniotic fluid. Since a sample of fetal blood at 27 WA showed that hypothyroidism was compensated and that goiter size and amniotic fluid volume were stable, intra-amniotic injection of 300 micrograms of L-thyroxine was delayed until 36 WA. This injection was performed before delivery to avoid potential perinatal complications (dystocia and neonatal respiratory distress) caused by large goiters.
authors.affiliation: Département de Gynécologie-Obstétrique, Hôpital Mère-Enfant, Centre Hospitalier Régional Universitaire, Nantes, France.
authors.forename: P
authors.initials: P
authors.lastname: Sagot
authors.forename: A
authors.initials: A
authors.lastname: David
authors.forename: M
authors.initials: M
authors.lastname: Yvinec
authors.forename: P
authors.initials: P
authors.lastname: Pousset
authors.forename: V
authors.initials: V
authors.lastname: Papon
authors.forename: A
authors.initials: A
authors.lastname: Mouzard
authors.forename: G
authors.initials: G
authors.lastname: Boog
mesh_terms: D000649:Amniocentesis; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D006042:Goiter / Q000000981:diagnostic imaging / Q000196:embryology / Q000628:therapy*; D006801:Humans; D008297:Male; D011247:Pregnancy; D016216:Ultrasonography, Prenatal