Pharmacokinetics of quinine and doxycycline in patients with acute falciparum malaria: a study in Africa.
The pharmacokinetics of quinine was investigated in patients with acute falciparum malaria treated with quinine alone or in the presence of doxycycline. Twenty-six patients divided into two groups of equal number were enrolled in the study. In the absence of doxycycline, the volume of distribution of quinine (mean +/- SD) was estimated to be 1.32 +/- 0.32 L/kg, and its clearance was 0.125 +/- 0.47 L/h/kg, which was only in partial agreement with previously published data. No effect of doxycycline on the pharmacokinetics of quinine was observed.
Couet
W
W
CEMAF s.a., Poitiers, France.
Laroche
R
R
Floch
J J
JJ
Istin
B
B
Fourtillan
J B
JB
Sauniere
J F
JF
D000293:Adolescent; D000328:Adult; D004318:Doxycycline / Q000097:blood / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011803:Quinine / Q000097:blood / Q000493:pharmacokinetics*
D011803:Quinine; D004318:Doxycycline