[Hepatic and renal transplantation in the treatment of type I hyperoxaluria].
Hyperoxaluria type I (HPI) is a metabolic disorder secondary to liver alanine glyoxylate aminotransferase deficiency. Renal failure occurs due to the excessive production and precipitation of oxalate in the kidney. Combined liver-renal transplantation is the correct treatment for this condition when end-stage renal failure occurs as with renal transplantation alone the risk of recurrence of the same pathology in the transplanted kidney would be high. We report the case of a 4 year-old child with HPI suffering from terminal renal failure in whom a hepato-renal transplantation was performed: six months later, creatinine clearance was 62 ml/min/1.73 m2 and liver function tests were normal.
Jouvet
P
P
Service de Réanimation Médicochirurgicale Pédiatrique Polyvalente, Hôpital des Enfants-Malades, Paris.
Hubert
P
P
Jan
D
D
Niaudet
P
P
Beringer
A
A
Narcy
C
C
Daudon
M
M
Broyer
M
M
Revillon
Y
Y
D000206:Actuarial Analysis; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000097:blood / Q000150:complications / Q000601:surgery* / Q000652:urine; D007223:Infant; D007676:Kidney Failure, Chronic / Q000209:etiology; D016030:Kidney Transplantation; D008111:Liver Function Tests; D016031:Liver Transplantation
D003404:Creatinine
Transplantation hépatique et rénale dans le traitement de l'hyperoxalurie de type I.