Formulation of 1-alpha,25-dihydroxycholecalciferol topical ointment for psoriasis treatment.
A means of accurate and rapid formulation of 1-Alpha,25-dihydroxycholecalciferol topical ointment is described. The accuracy of the formulation technique is within 95% of the theoretical ointment concentration (lug/gram of petrolatum base). Moreover, the stability of the formulated ointment is examined at room temperature (21 degrees C) and refrigerated (2 degrees C) over 40 days storage. When protected from light the loss of potency is 6% at 21 degrees C and negligible at 2 degrees C.
Hayball
P J
PJ
Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia.
Weightman
W
W
Cosh
D G
DG
D000287:Administration, Topical; D002117:Calcitriol / Q000008:administration & dosage / Q000737:chemistry*; D004355:Drug Stability; D006801:Humans; D009824:Ointments; D011565:Psoriasis / Q000188:drug therapy*
D009824:Ointments; D002117:Calcitriol