title: Preparation and antiproliferative activity of 1H-pyrrolo [2,3-f]quinolinium and isoquinolinium iodides.
abstract: 2-Carbomethoxy-N-methyl-1H-pyrrolo[2,3-f]quinolinium and isoquinolinium iodides were prepared. Their in vitro ability to form complexes with DNA is enhanced in respect to parent compounds. This, however, does not appear to be agreement with their ability to inhibit cellular DNA sunthesis.
authors.affiliation: Dipartimento di Scienze Farmaceutiche dell'Università Centro di Studio Sulla Chimica del Farmaco e dei Prodotti Biologicamente Attivi del CNR, Padova, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Ferlin
authors.forename: G
authors.initials: G
authors.lastname: Chiarelotto
authors.forename: O
authors.initials: O
authors.lastname: Gia
authors.forename: F
authors.initials: F
authors.lastname: Baccichetti
authors.forename: F
authors.initials: F
authors.lastname: Carlassare
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects*; D002942:Circular Dichroism; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects* / Q000378:metabolism; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; D007546:Isoquinolines; D011758:Pyrroles; D011804:Quinolines