Effects of L-histidinol on the proliferation and anticancer drug susceptibility of cultured B16f10 melanoma cells.
L-Histidinol, a structural analogue of the essential amino acid L-histidine, is able to enhance the toxicity of a wide variety of anticancer drugs to tumor cells both in vitro and in vivo. In this study, the effects of L-histidinol on the viability, cell cycle traverse and anticancer drug susceptibility of B16f10 melanoma cells in culture have been examined. L-Histidinol inhibited the transit of B16f10 melanoma cells through the cell cycle in a dose-dependent manner. In spite of its capacity to slow cell cycle progression, L-histidinol nevertheless increased the capacity of several antineoplastic agents of varying modes of action to kill B16f10 melanoma cells.
Warrington
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RC
Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada.
Cheng
I
I
Fang
W
W
D002330:Carmustine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D003561:Cytarabine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005472:Fluorouracil / Q000494:pharmacology; D006641:Histidinol / Q000494:pharmacology*; D007399:Interphase / Q000187:drug effects; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000473:pathology*; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology
D003561:Cytarabine; D006641:Histidinol; D014747:Vinblastine; D005472:Fluorouracil; D002330:Carmustine