[The light sensitivity of corticosteroids in crystalline form. Photochemical studies. 59. (1)].
The light sensitivity of corticosteroids in the solid state have been investigated and the photodecomposition rates of the compounds have been estimated by HPLC. After 48 h UV-irradiation desoxycortone acetate, hydrocortisone, hydrocortisone acetate, prednisolone, methylprednisolone, dexamethasone, betamethasone and triamcinolone acetonide decompose between 20 and 50%. Cortisone acetate, prednisone and fluocinolone acetonide show photostability in contrast to requirements of the Pharmacopeia for light protections.
Takács
M
M
Institut für Pharmazeutische Chemie, Semmelweis Medizinischen Universität.
Ekiz-Gücer
N
N
Reisch
J
J
Gergely-Zobin
A
A
D000305:Adrenal Cortex Hormones / Q000737:chemistry / Q000528:radiation effects*; D002851:Chromatography, High Pressure Liquid; D008027:Light; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet
D000305:Adrenal Cortex Hormones
Lichtempfindlichkeit von Corticosteroiden in kristallinem Zustand. Photochemische Studien, 59. Mitt. [1].