The metabolism of tamoxifen by human liver microsomes is not mediated by cytochrome P450IID6.
Blankson
E A
EA
University Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, U.K.
Ellis
S W
SW
Lennard
M S
MS
Tucker
G T
GT
Rogers
K
K
D019389:Cytochrome P-450 CYP2D6; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D011802:Quinidine / Q000494:pharmacology; D013379:Substrate Specificity; D013629:Tamoxifen / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics
D065607:Cytochrome P-450 Enzyme Inhibitors; D013629:Tamoxifen; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6; D011802:Quinidine; C028787:N-desmethyltamoxifen