title: Anthelmintic activity of paraherquamide in dogs.
abstract: Paraherquamide, an oxindole alkaloid metabolite of Penicillium paraherquei and Penicillium charlesii, was tested against the common gastrointestinal nematodes of dogs at a single oral dosage of 0.5, 1.0, or 2.0 mg kg-1. Efficacy was poor (less than 85%) against Ancylostoma caninum, Uncinaria stenocephala, Toxascaris leonina, Trichuris vulpis, and Strongyloides stercoralis at the low- and mid-dosage levels. At the high dosage level, good efficacy (91%) was observed only against S. stercoralis. Adverse reactions were observed in all dogs at every dosage level and included depression, ataxia, and protrusion of the nictitating membrane.
authors.affiliation: Merck Institute for Therapeutic Research, Rahway, NJ 07065.
authors.forename: W L
authors.initials: WL
authors.lastname: Shoop
authors.forename: C H
authors.initials: CH
authors.lastname: Eary
authors.forename: B F
authors.initials: BF
authors.lastname: Michael
authors.forename: H W
authors.initials: HW
authors.lastname: Haines
authors.forename: R L
authors.initials: RL
authors.lastname: Seward
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D007212:Indolizines / Q000627:therapeutic use*; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D013141:Spiro Compounds / Q000627:therapeutic use*
chemical_list: D000871:Anthelmintics; D007212:Indolizines; D013141:Spiro Compounds; C063985:paraherquamide