title: Endocrine cells in a normal breast and non-cancerous breast lesion.
abstract: The authors confirmed the presence of endocrine cells for the first time in a normal breast as well as in a non-cancerous lesion of the breast. One hundred and eighty-eight blocks of normal breast tissues in 44 cases and 74 blocks of non-cancerous lesions in 35 cases were examined. Argyrophil cells were found in one block from a normal breast and in one block from a phyllodes tumor. Argyrophil cells in the normal breast showed positive reaction to anti-endocrine granule constituent (EGC) antibody with immunohistochemical method. Argyrophil cells found in the phyllodes tumor gave positive reaction to both anti-EGC and anti-serotonin antibodies. The present study is thought to be the first report in the literature of serotonin-positive cells in a non-cancerous breast lesion, a phyllodes tumor.
authors.affiliation: Department of Clinical Pathology, Nagoya Ekisaikai Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Satake
authors.forename: M
authors.initials: M
authors.lastname: Matsuyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000737:chemistry / Q000166:cytology* / Q000473:pathology / Q000648:ultrastructure; D001941:Breast Diseases / Q000378:metabolism / Q000473:pathology*; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology*; D003594:Cytoplasmic Granules / Q000737:chemistry; D005260:Female; D005348:Fibrocystic Breast Disease / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D012701:Serotonin / Q000032:analysis*; D016622:Silver Staining
chemical_list: D012701:Serotonin