The ability of rifampin-resistant Escherichia coli to colonize the mouse intestine is enhanced by the presence of a plasmid-encoded aerobactin-iron(III) uptake system.
Rifampin-resistant Escherichia coli are known to be poor colonizers of the animal intestine. In this report, we show that the colonizing ability of rifampin-resistant E. coli cells is increased dramatically in the presence of the aerobactin-mediated iron(III) uptake system. In contrast, the colonization by nalidixic acid-resistant E. coli does neither depend on the aerobactin-iron(III) nor on the dicitrate-iron(III) uptake system. Likewise, it does not depend on the production of the siderophore enterochelin.
Stojiljković
I
I
Department of Molecular Genetics, Ruder Bosković Institute, Zagreb, Yugoslavia.
Cobeljić
M
M
Trgovcević
Z
Z
Salaj-Smic
E
E
D000818:Animals; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D006877:Hydroxamic Acids / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*; D007502:Iron Chelating Agents / Q000378:metabolism*; D051379:Mice; D010957:Plasmids / Q000187:drug effects / Q000235:genetics; D012293:Rifampin / Q000494:pharmacology*; D013307:Streptomycin / Q000494:pharmacology
D006877:Hydroxamic Acids; D007502:Iron Chelating Agents; C031819:aerobactin; D012293:Rifampin; D013307:Streptomycin