[The characteristics of the long-term continuous cultivation of a cell line chronically infected with the human immunodeficiency virus type-1].
A chronically HIV-1-infected culture of continuous human monocytes producing infectious virus during long-term continuous cultivation (over 200 passages) without the addition of noninfected cells was generated. HIV-1 produced by this culture had typical morphology and complete set of virus-specific proteins. This cell line is proposed for use as an additional model for the evaluation of antiviral effects of various drugs.
Mamaeva
O A
OA
Pliasunova
O A
OA
Proniaeva
T R
TR
Pokrovskiĭ
A G
AG
Tkachev
V K
VK
Karamov
E V
EV
Rudneva
I A
IA
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D002460:Cell Line; D002478:Cells, Cultured / Q000382:microbiology; D002908:Chronic Disease; D003470:Culture Media; D015488:HIV Antigens / Q000032:analysis; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D009000:Monocytes / Q000382:microbiology; D012692:Serial Passage; D014764:Viral Proteins / Q000032:analysis; D014776:Virus Cultivation / Q000379:methods
D003470:Culture Media; D015488:HIV Antigens; D014764:Viral Proteins
Osobennosti dlitel'nogo nepreryvnogo kul'tivirovaniia linii kletok, khronicheski infitsirovannoĭ virusom immunodefitsita cheloveka 1 tipa.