title: Detrimental effect of acute renal failure on the survival of renal allografts: influence of total ischaemia time and anastomosis time.
abstract: In a retrospective study the incidence and consequences of acute renal failure were evaluated in 324 renal transplantations performed in our centre. The overall incidence of acute renal failure was 31.2%. In recipients with acute renal failure, patient and graft survival were significantly worse than in those without acute renal failure (P less than 0.02 and P less than 0.0001 respectively). Acute renal failure also increased the morbidity during the first 3 months after transplantation. Three months after transplantation renal function as determined by serum creatinine and proteinuria, was less satisfactory. Factors influencing the incidence of acute renal failure appeared to be: match grade on the AB locus, percentage of antibodies, duration of dialysis, number of blood transfusions prior to transplantation, anastomosis time and total ischaemia time. Recipients transplanted for the first time were less likely to develop acute renal failure, but also for this group total ischaemia time was a prognostic factor for the development of acute renal failure. When recipients were allocated to different classes of total ischaemia time it appeared that the incidence of acute renal failure differed, especially between groups with total ischaemia time 32-36 h (27%) and 36-40 h (38%). The difference in acute renal failure between these groups was also reflected in a difference in graft survival for total ischaemia time less than 36 h and greater than 36 h. Thus, it appears that acute renal failure has a detrimental effect on graft survival and postoperative morbidity in renal transplantation. Total ischaemia time is one of the prognostic factors for the development of acute renal failure. To improve renal transplantation results it is worth attempting to shorten total ischaemia time.
authors.affiliation: Department of Medicine, University Hospital, Nijmegen, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Merkus
authors.forename: A J
authors.initials: AJ
authors.lastname: Hoitsma
authors.forename: R A
authors.initials: RA
authors.lastname: Koene
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000328:Adult; D006085:Graft Survival; D006801:Humans; D007511:Ischemia; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors