[Risk factors and survival prognosis in lymphogranulomatosis: a statistical analysis].
To examine risk factors and to design prognostic models for the total, relapse-free and after-relapse survival, use was made of the Cox model for unifactorial and multidimensional analysis based on the retrospective estimation of the results of the treatment of 235 patients with lymphogranulomatosis, stages II-III. Radiotherapy according to the radical program was carried out in conjunction with polychemotherapy according to the COPP scheme. The number of areas of damage, massiveness of injury to the mediastinum, involvement of the spleen into the process appeared the most informative risk factors for predicting both total and relapse-free survival. The prediction of the after-relapse survival was considerably influenced by the age combined with carrying out of not less than 3 cycles of polychemotherapy given to the patients during initial treatment or with the presence of intoxication symptoms and increased ESR. The tables of the survival probability were calculated.
Pan'shin
G A
GA
Sotnikov
V M
VM
Datsenko
P V
PV
Korobov
K V
KV
Novikov
I D
ID
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D001330:Electronic Data Processing; D006689:Hodgkin Disease / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D006801:Humans; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D011379:Prognosis; D016016:Proportional Hazards Models; D011878:Radiotherapy; D012008:Recurrence; D012307:Risk Factors; D012984:Software; D014586:USSR / Q000453:epidemiology; D014750:Vincristine / Q000008:administration & dosage
D011344:Procarbazine; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone
Faktory riska i prognozirovanie vyzhivaemosti pri limfogranulematoze: statisticheskiĭ analiz.