title: Phase II trial of mitoxantrone in acute lymphocytic leukemia of childhood. A Pediatric Oncology Group study.
abstract: Thirty children with refractory acute lymphocytic leukemia (ALL) were treated with mitoxantrone, 8 mg/m2/day, for 5 days. Three children received a second course of the drug 3 to 4 weeks later. All but two patients had received prior anthracycline therapy. There were 2 complete responses, 4 early deaths, and 24 patients with persistent leukemia. Of the 21 patients with circulating blasts at the start of mitoxantrone who did not achieve remission, 16 (76%) had complete clearance of their peripheral blood blasts. Although all patients developed profound neutropenia (less than 100 per mm-3), mucosal and hepatic toxicities were uncommon and mild. Mitoxantrone has moderate activity in childhood ALL and should be considered for further trials in less heavily pretreated patients.
authors.affiliation: Duke University Medical Center, Durham, NC.
authors.forename: M L
authors.initials: ML
authors.lastname: Graham
authors.forename: J
authors.initials: J
authors.lastname: Estrada
authors.forename: A H
authors.initials: AH
authors.lastname: Ragab
authors.forename: K A
authors.initials: KA
authors.lastname: Starling
authors.forename: D
authors.initials: D
authors.lastname: Rosen
authors.forename: R W
authors.initials: RW
authors.lastname: Wilkenson
authors.forename: R W
authors.initials: RW
authors.lastname: Wilkerson
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008942:Mitoxantrone / Q000009:adverse effects / Q000627:therapeutic use*; D009325:Nausea / Q000139:chemically induced; D009504:Neutrophils / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D014839:Vomiting / Q000139:chemically induced
chemical_list: D008942:Mitoxantrone