title: Treatment of canine appendicular osteosarcoma using cobalt 60 radiation and intraarterial cisplatin.
abstract: Twelve dogs with appendicular osteosarcoma were treated with 24-40 Gy of cobalt 60 radiation and two doses of intraarterial cisplatin. Improvement in limb function occurred in four dogs, and three dogs, which had only mild initial lameness, had no worsening of their lameness post-treatment. In nine dogs in which local control was evaluable, eight had local failure, with the median (95% CI) duration of local control being 5.9 (4.6, 6.7) months. Two dogs had metastatic disease before therapy, and an additional nine dogs had metastatic disease at a median time of 6.4 months. Pathologic fracture was present in four dogs; two fractures occurred before treatment and two were documented at the time of tumor recurrence. Median (95% CI) survival time for all 12 dogs was 4.9 (3.4, 6.8) months. Excluding the two dogs with preexisting metastatic disease, median survival time was 6.7 months. Three dogs survived longer than 1 year. This mode of therapy was well tolerated and may be considered an alternative to amputation or limb-sparing surgical procedures in selected dogs with appendicular osteosarcoma.
authors.affiliation: Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
authors.forename: G L
authors.initials: GL
authors.lastname: Heidner
authors.forename: R L
authors.initials: RL
authors.lastname: Page
authors.forename: M C
authors.initials: MC
authors.lastname: McEntee
authors.forename: R K
authors.initials: RK
authors.lastname: Dodge
authors.forename: D E
authors.initials: DE
authors.lastname: Thrall
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000662:veterinary*; D017024:Chemotherapy, Adjuvant / Q000662:veterinary; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D004285:Dogs; D005121:Extremities; D005260:Female; D007260:Infusion Pumps / Q000662:veterinary; D007261:Infusions, Intra-Arterial / Q000662:veterinary; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy / Q000532:radiotherapy / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D003037:Cobalt Radioisotopes; D002945:Cisplatin