[Status of the antioxidant system and lipid peroxidation in rat liver after poisoning animals with aminobiphenyl].
It was found that intoxication of animals with aminobiphenyls leads to the activation of such glutathione-dependent enzymes as glutathione-S-transferase and glutathione reductase. This is accompanied by the induction of activities of individual isoforms of the multifunctional family of glutathione-S-transferases. There was a decrease in the glutathione peroxidase activity after intoxication with benzidine derivatives. It was found that the GSH content in rat liver decreased after benzidine intoxication and sharply increased after effects of 3,3'-dimethylbenzidine and 3,3'-dimethoxybenzidine. In all cases studied there was a diminution in the level of diene conjugates. It was supposed that the specificity of the catalytic glutathione redox system reaction is due to structural peculiarities of the aminobiphenyls being injected. Analysis of functional pairs of glutathione-dependent enzymes revealed a certain imbalance in the antioxidant system function after aminobiphenyl poisoning.
Semak
T G
TG
Kurchenko
V P
VP
Pikulev
A T
AT
D000611:Aminobiphenyl Compounds / Q000506:poisoning*; D000818:Animals; D000975:Antioxidants; D001560:Benzidines; D002273:Carcinogens; D003962:Dianisidine / Q000506:poisoning; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats
D000611:Aminobiphenyl Compounds; D000975:Antioxidants; D001560:Benzidines; D002273:Carcinogens; C009501:2-tolidine; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D003962:Dianisidine
Sostoianie antioksidantnoĭ sistemy i perekisnogo okisleniia lipidov v pecheni krys posle intoksikatsii zhivotnykh aminobifenilami.