[Lymphocyte response of blast transformation and some parameters of hormonal status in patients with type II diabetes mellitus].
Tests were conducted to analyze a blastogenic response of lymphocytes to phytohemagglutinin (PHA) in autoserum and bovine serum and the hormone level of blood of the second-type diabetes patients. The results indicate that there is a positive correlation between a blastogenic response to PHA in the autoserum medium on the one hand and the T4 level and insulin on the other hand. There is a negative correlation between the first factor and the glycemic index and the duration of disease. There is no correlation between a mitogenic response and the examinees' age. The blood insulin level also correlates with a mitogenic response of lymphocytes in bovine serum. The examination of patients in the compensation stage suggests a negative correlation between a cortisol level and the stimulation index logarithm of a mitogenic response in bovine serum. This correlation did not exist in cases of decompensated diabetes.
Efimov
A S
AS
Iakovenko
A M
AM
D000328:Adult; D000368:Aged; D001752:Blast Crisis / Q000097:blood* / Q000139:chemically induced; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins; D013974:Thyroxine / Q000097:blood*
D007328:Insulin; D010835:Phytohemagglutinins; D013974:Thyroxine; D006854:Hydrocortisone
Reaktsiia blasttransformatsii limfotsitov i nekotorye pokazateli gormonal'nogo statusa u bol'nykh sakharnym diabetom II tipa.