title: Haemofiltration or haemodialysis in aluminium elimination?
abstract: Elimination of aluminium from the body during haemodialysis and haemofiltration was investigated. Without desferrioxamine administration there was no aluminium removal from the body. After DFO administration (1 g intravenously 24-40 h before dialysis or haemofiltration) removal of aluminium during blood purification methods was achieved. During haemodialysis (n = 28, cuprophane plate dialyser with urea clearance 150 ml/min, 5 h) serum aluminium decreased by 41%. Aluminium clearance was 28 ml/min. During haemofiltration (n = 36, polyamide FH 77, volume exchange 60% of body-weight, on-line system) serum aluminium decreased by 66% and a total of 1962 micrograms of aluminium was removed during one procedure. In the 60th minute of the procedure, calculated clearance was 42 mmol/l. Because of the rebound phenomenon it is reasonable to perform two haemofiltrations after a single dose of DFO. Haemofiltration is superior to haemodialysis in aluminium removal from the body.
authors.affiliation: Department of Medicine, Charles University Medical School, Prague-Strahov, Czechoslovakia.
authors.forename: S
authors.initials: S
authors.lastname: Sulkova
authors.forename: Z
authors.initials: Z
authors.lastname: Laurincova
authors.forename: A
authors.initials: A
authors.lastname: Válek
mesh_terms: D000535:Aluminum / Q000097:blood / Q000302:isolation & purification / Q000506:poisoning*; D003676:Deferoxamine / Q000008:administration & dosage; D005069:Evaluation Studies as Topic; D006440:Hemofiltration; D006801:Humans; D006435:Renal Dialysis
chemical_list: D000535:Aluminum; D003676:Deferoxamine