[Toxicologic evaluation of sucrose carbonic acid esters in basic subchronic feeding studies in rats. 2. Effect of sucroacetoglycerides].
Groups of male and female rats received a sucroacetoglycerides containing product (SAG) for 3 months at dietary levels of 0, 2.5, 5 and 10%. Food consumption was initially increased in females at all SAG-levels. After two weeks significant increases in food intake were observed in males and females fed 10% SAG throughout the feeding period. The serum analysis revealed significantly elevated activity in serum alkaline phosphatase at the highest SAG-level in males and females after 6 weeks and in females after 13 weeks. Histological changes related to the SAG-feeding were noted in the intestinal lymph nodes of male and female animals fed 10% SAG. The no-adverse effect level established in this subchronic feeding study was 5% SAG in the diet of rats, equivalent to a daily intake of 3.6 g/kg body weight in males and 4.0 g/kg in females.
Lewerenz
H J
HJ
Zentralinstitut für Ernährung in Potsdam-Rehbrücke, Bundesrepublik Deutschland.
Mieth
G
G
Bleyl
D W
DW
Plass
R
R
Elsner
A
A
D000085:Acetates / Q000633:toxicity; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D002255:Carbonic Acid / Q000633:toxicity; D004435:Eating / Q000187:drug effects; D004952:Esters / Q000633:toxicity; D005227:Fatty Acids / Q000633:toxicity; D005260:Female; D005989:Glycerides / Q000633:toxicity*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D051381:Rats; D013395:Sucrose / Q000031:analogs & derivatives* / Q000633:toxicity
D000085:Acetates; D004952:Esters; D005227:Fatty Acids; D005989:Glycerides; D002255:Carbonic Acid; D013395:Sucrose; D000469:Alkaline Phosphatase
Toxikologische Beurteilung von Saccharosecarbonsäureestern auf der Grundlage subchronischer Fütterungsversche mit Ratten. 2. Mitt. Wirkung von Sucroacetoglyceriden.