title: Ontogeny of monooxygenase activities in the marmoset monkey (Callithrix jacchus).
abstract: The pre- and postnatal development of monooxygenases in the liver and adrenal gland of marmoset monkeys (Callithrix jacchus) was investigated. Cytochrome P450 was detected in the fetal adrenal gland, but aldrin epoxidase, ethoxycoumarin O-deethylase, and ethoxyresorufin O-deethylase activities were below detection limits. Although fetal hepatic cytochrome P450 was not detected, low activities of aldrin epoxidase and ethoxycoumarin O-deethylase, but no ethoxyresorufin O-deethylase, could be detected in fetal liver. These enzymes attained adult marmosets activities when the offspring were approximately 2 months of age.
authors.affiliation: Institut für Toxikologie und Embryopharmakologie, Freie Universität Berlin, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Schulz-Schalge
authors.forename: W
authors.initials: W
authors.lastname: Heger
authors.forename: J
authors.initials: J
authors.lastname: Webb
authors.forename: M
authors.initials: M
authors.lastname: Kastner
authors.forename: D
authors.initials: D
authors.lastname: Neubert
mesh_terms: D015660:7-Alkoxycoumarin O-Dealkylase / Q000378:metabolism; D000311:Adrenal Glands / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D000818:Animals; D002144:Callithrix / Q000196:embryology* / Q000254:growth & development; D019363:Cytochrome P-450 CYP1A1; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D008099:Liver / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D010105:Oxygenases / Q000378:metabolism*; D011506:Proteins / Q000032:analysis
chemical_list: D011506:Proteins; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; C019647:aldrin epoxidase; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D019363:Cytochrome P-450 CYP1A1