title: [Microangiopathic hemolytic anemia associated with mitomycin-C treatment].
abstract: We present a case of a patient with non-resected epidermoid carcinoma of the anal canal, treated with a combination of radiotherapy regional and chemotherapy according to MMC-Ufelos protocol. After the application of the fourth chemotherapy cycle, the patient presented microangiopathic hemolytic anemia associated to Mitomycin-C, which was treated with the application of recurrent plasmapheresis and restricted transfusions of red corpuscles concentrate. The physiopathology of this disorder and its therapeutical implications are review.
authors.affiliation: Servicio de Medicina Interna, Hospital General Universitario, Valencia.
authors.forename: M
authors.initials: M
authors.lastname: Godes
authors.forename: C
authors.initials: C
authors.lastname: Camps
authors.forename: A
authors.initials: A
authors.lastname: Martínez
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects*
chemical_list: D016685:Mitomycin
vernacular_title: Anemia hemolítica microangiopática asociada al tratamiento con mitomicina-C.