title: A prospective comparison between magnetic resonance imaging, meta-iodobenzylguanidine scintigraphy and marrow histology/cytology in neuroblastoma.
abstract: A prospective comparison between magnetic resonance imaging (MRI), 123I meta-iodobenzylguanidine (mIBG) scintigraphy and posterior iliac crest marrow aspiration and trephine biopsy in 30 assessments (19 patients) showed concordance between the three techniques in 16 assessments (53.3%). In 10 (33.3%), MRI and mIBG revealed abnormalities not detected by marrow biopsy. MRI was the only technique to demonstrate marrow abnormality in four assessments (13.3%). In addition, MRI revealed more sites of abnormality in 16 parallel assessments. We conclude that MRI shows promise as a non-invasive means of detecting bone marrow infiltration by neuroblastoma, but that further evaluation of the specificity of MRI in this setting is indicated.
authors.affiliation: Department of Paediatrics, Royal Marsden Hospital, Sutton, Surrey, U.K.
authors.forename: R
authors.initials: R
authors.lastname: Corbett
authors.forename: J
authors.initials: J
authors.lastname: Olliff
authors.forename: N
authors.initials: N
authors.lastname: Fairley
authors.forename: J
authors.initials: J
authors.lastname: Moyes
authors.forename: J
authors.initials: J
authors.lastname: Husband
authors.forename: R
authors.initials: R
authors.lastname: Pinkerton
authors.forename: R
authors.initials: R
authors.lastname: Carter
authors.forename: J
authors.initials: J
authors.lastname: Treleaven
authors.forename: T
authors.initials: T
authors.lastname: McElwain
authors.forename: S
authors.initials: S
authors.lastname: Meller
mesh_terms: D019797:3-Iodobenzylguanidine; D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology*; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007462:Iodobenzenes; D008279:Magnetic Resonance Imaging; D008297:Male; D009447:Neuroblastoma / Q000000981:diagnostic imaging / Q000473:pathology*; D011446:Prospective Studies; D011877:Radionuclide Imaging
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine