[Pathological observation of experimental asbestosis treated by hydroxy piperquin phosphate in dogs].
The paper presents experimental asbestosis treated with hydroxy piperquin phosphate (HPQP) in dogs. Results showed that the total cell number of bronchoalveolar lavage fluid, the viability of alveolar macrophages and the enzyme activities of lactate dehydrogenase, acid phosphatase and beta-glucuronidase of alveolar macrophages in treated dogs were higher than those in exposed dogs, asbestos fibers contents in the lungs and the mean scores of lung lesions in the treated dogs were markedly less than those in the exposed dogs. These findings support that HPQP may play a role in protecting alveolar macrophages from damage and inhibiting the progression of lung fibrosis, and that the clinical application of HPQP is somehow evidenced by this study.
Li
H
H
Department of Pathology, Occupational Diseases Hospital of Prevention and Treatment.
Wu
Z
Z
Zheng
X
X
Liu
S
S
Zheng
Z
Z
Zeng
L
L
Duanmu
B
B
Ke
F
F
Yan
H
H
Qing
Y
Y
D000818:Animals; D001195:Asbestosis / Q000188:drug therapy* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002452:Cell Count / Q000187:drug effects; D004285:Dogs; D008168:Lung / Q000648:ultrastructure; D008264:Macrophages / Q000187:drug effects; D008297:Male; D011804:Quinolines / Q000494:pharmacology / Q000627:therapeutic use*
D011804:Quinolines; C030684:hydroxypiperaquine