title: Generally recognized as safe (GRAS) evaluation of 4-hexylresorcinol for use as a processing aid for prevention of melanosis in shrimp.
abstract: 4-Hexylresorcinol (C12H18O2) is proposed for use as a processing aid for prevention of melanosis ("black spot") in shrimp and as an alternative to the currently approved sulfites. A safety evaluation was conducted to affirm, based upon scientific procedures, the generally recognized as safe ("GRAS") status of 4-hexylresorcinol for proposed use. The GRAS safety evaluation compiled, reviewed, and analyzed data on the following areas: chemical identity, analytical methodology, historical and proposed uses, functionality, and safety. The publicly available safety data on 4-hexylresorcinol cover a broad range of potential toxicity concerns including acute and subacute toxicity, subchronic toxicity, carcinogenicity, mutagenicity, and allergenicity. These studies, along with the aforementioned data, demonstrate that 4-hexylresorcinol presents no risk of toxicity at the levels proposed for treatment of shrimp, and the use of 4-hexylresorcinol as a processing aid to prevent melanosis in shrimp is GRAS.
authors.affiliation: ENVIRON Corporation, Arlington, Virginia 22203.
authors.forename: V H
authors.initials: VH
authors.lastname: Frankos
authors.forename: D F
authors.initials: DF
authors.lastname: Schmitt
authors.forename: L C
authors.initials: LC
authors.lastname: Haws
authors.forename: A J
authors.initials: AJ
authors.lastname: McEvily
authors.forename: R
authors.initials: R
authors.lastname: Iyengar
authors.forename: S A
authors.initials: SA
authors.lastname: Miller
authors.forename: I C
authors.initials: IC
authors.lastname: Munro
authors.forename: F M
authors.initials: FM
authors.lastname: Clydesdale
authors.forename: A L
authors.initials: AL
authors.lastname: Forbes
authors.forename: R M
authors.initials: RM
authors.lastname: Sauer
mesh_terms: D000818:Animals; D033364:Decapoda; D006168:Guinea Pigs; D006604:Hexylresorcinol / Q000633:toxicity*; D006801:Humans; D008548:Melanosis / Q000517:prevention & control / Q000662:veterinary*; D051379:Mice; D051381:Rats
chemical_list: D006604:Hexylresorcinol