Increased iron absorption in uroporphyrin-treated rats.
Rats were given 59Fe (28 micrograms) together with doses of 0, 2 and 200 micrograms of uroporphyrin III in paired observations. Absorption of 59Fe was determined by comparing whole body counts of the rats 30 min and 7 days after dosing. Prior treatment with 200 micrograms of uroporphyrin twice daily for 3 days was associated with significantly increased 59Fe absorption of 6.2% compared to the absorption of 4.6% without uroporphyrin (control) and 4.6% with a 2-micrograms dose (p less than 0.05).
Weaver
G A
GA
Department of Medicine, Mary Imogene Bassett Hospital, Cooperstown, N.Y.
Franck
C A
CA
Harris
M D
MD
Peters
T
T
D000818:Animals; D007408:Intestinal Absorption / Q000187:drug effects*; D007501:Iron / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014578:Uroporphyrins / Q000494:pharmacology*
D014578:Uroporphyrins; C022181:uroporphyrin III; D007501:Iron