Microencapsulated dopamine (DA)-induced restitution of function in 6-OHDA-denervated rat striatum in vivo: comparison between two microsphere excipients.
Biodegradable controlled-release microsphere systems made with the biocompatible biodegradable polyester excipient poly [DL lactide-co-glycolide] constitute an exciting new technology for drug delivery to the central nervous system (CNS). The present study describes functional observations indicating that implantation of dopamine (DA) microspheres encapsulated within two different polymer excipients into denervated-striatal tissue assures a prolonged release of the transmitter in vivo. Moreover, in this regard, the results show that there were clear cut temporal differences in the effect of the two DA microsphere formulations compared in this study, probably reflecting variations in the actual composition (i.e., lactide to glycolide ratio) of the two copolymer excipients examined. This technology has considerable potential for basic research with possible clinical application.
McRae
A
A
Department of Histology, University of Göteborg, Sweden.
Hjorth
S
S
Mason
D W
DW
Dillon
L
L
Tice
T R
TR
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum; D003714:Denervation; D004298:Dopamine / Q000008:administration & dosage*; D004339:Drug Compounding / Q000379:methods*; D004343:Drug Implants; D005079:Excipients; D008297:Male; D008863:Microspheres; D009043:Motor Activity / Q000187:drug effects; D016627:Oxidopamine / Q000633:toxicity; D011098:Polyglactin 910; D051381:Rats; D011919:Rats, Inbred Strains
D004343:Drug Implants; D005079:Excipients; D011098:Polyglactin 910; D016627:Oxidopamine; D001058:Apomorphine; D004298:Dopamine