Cerebrospinal fluid pressure in conscious head-down tilted rats.
Cerebrospinal fluid pressure (PCSF) was continuously measured in conscious male Sprague-Dawley rats gently restrained by a cotton towel. PCSF, evaluated in 15-min time blocks over a 3-h experiment, increased slightly (p less than 0.05) during the first 30 min of a control hour at 0 degree. There was a transient increase for about 5 min immediately after tilt (-45 degrees) that may have been due to head movement after the position change. However, PCSF was statistically unchanged (p greater than 0.05) during the 2nd (-45 degrees) hour and the 3rd (0 degree) recovery hour. The data show that the dynamics of intracranial pressure regulation can accommodate the acute cephalad fluid shift after tilting.
Severs
W B
WB
Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey 17033.
Morrow
B A
BA
Keil
L C
LC
D000818:Animals; D002496:Central Venous Pressure / Q000502:physiology; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology*; D003243:Consciousness / Q000502:physiology; D006112:Gravitation; D007427:Intracranial Pressure / Q000502:physiology; D008297:Male; D011187:Posture; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D013997:Time Factors