title: [Hyp3]-tuftsin ([Hyp3]-TU) synthesis and biological activity.
abstract: [Hyp3]-tuftsin (Thr-Lys-Hyp-Arg) has been synthesized by the liquid-phase method. In biological investigations performed on rats antinociceptive and diuretic effects have been determined. It has been suggested that the presence of hydroxyl substituent in pyrrolidine ring of proline slightly modifies antinociceptive TU effect and is responsible for the increased diuretic [Hyp3]-TU activity.
authors.affiliation: Department of Pharmacology Silesian Academy of Medicine, Zabrze.
authors.forename: U
authors.initials: U
authors.lastname: Galasik-Bartoszek
authors.forename: D
authors.initials: D
authors.lastname: Konopińska
authors.forename: A
authors.initials: A
authors.lastname: Plech
authors.forename: V A
authors.initials: VA
authors.lastname: Najjar
authors.forename: R
authors.initials: R
authors.lastname: Brus
mesh_terms: D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D009270:Naloxone; D009619:Nociceptors / Q000187:drug effects*; D011392:Proline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014405:Tuftsin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C072882:tuftsin, Hyp(3)-; D009270:Naloxone; D011392:Proline; D014405:Tuftsin