Antifertility activity of volatile fraction of neem oil.
NIM-76, the odorous and volatile fraction of neem oil, was investigated for its antifertility activity in vivo in rats, rabbits and rhesus monkeys. The drug is effective when applied before coitus but not so when applied during post-coital stages. It, therefore, appears to act mainly by its spermicidal effect. No alteration in the estradiol (E2) and progesterone (P) values was observed after the application of the drug in monkeys.
Riar
S S
SS
Defence Institute of Physiology and Allied Sciences, Delhi Cantt, India.
Devakumar
C
C
Sawhney
R C
RC
Ilavazhagan
G
G
Bardhan
J
J
Kain
A K
AK
Thomas
P
P
Singh
R
R
Singh
B
B
Parshad
R
R
D000818:Animals; D003271:Contraceptive Agents, Female; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D010064:Embryo Implantation / Q000187:drug effects; D047108:Embryonic Development; D004958:Estradiol / Q000097:blood; D005260:Female; D005989:Glycerides / Q000494:pharmacology*; D008253:Macaca mulatta; D008597:Menstrual Cycle / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000494:pharmacology*
D003271:Contraceptive Agents, Female; D005989:Glycerides; D013729:Terpenes; C002443:neem oil; D011374:Progesterone; D004958:Estradiol