title: [Angioimmunoblastic lymphadenopathy: a pathogenetic intersection between dysimmune, viral and lymphomatous diseases].
abstract: Angioimmunoblastic lymphadenopathy (AIL) still is a clinico-pathological syndrome with little known physiopathology. The advent of molecular biology has improved our understanding of this syndrome by characterization of the clonal cell. With this technique, combined with cytogenetics and immunohistochemistry, three pathological states have been individualized: 1) true AIL without evidence of monoclonal proliferation; 2) transformed AIL, and 3) AIL-like T-cell lymphoma. This clinical complex can be integrated in an evolutive continuum, starting with simple lymphoid hyperplasia and ending with frank malignant T-cell lymphoma.
authors.affiliation: Service d'Hématologie, CHR, Besançon.
authors.forename: T
authors.initials: T
authors.lastname: Fest
authors.forename: R
authors.initials: R
authors.lastname: Angonin
authors.forename: J L
authors.initials: JL
authors.lastname: Dupond
authors.forename: J Y
authors.initials: JY
authors.lastname: Cahn
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D002999:Clone Cells; D003582:Cytogenetics; D006801:Humans; D007154:Immune System Diseases / Q000175:diagnosis / Q000276:immunology; D007119:Immunoblastic Lymphadenopathy / Q000175:diagnosis* / Q000276:immunology; D007150:Immunohistochemistry; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000276:immunology; D014777:Virus Diseases / Q000175:diagnosis / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal
vernacular_title: La lymphadénopathie angio-immunoblastique: carrefour pathogénique entre maladies dysimmunitaires, virales et lymphomateuses.