Serum interleukin-2 receptor levels and cutaneous T-cell lymphoma.
The serum of twenty-four patients with histopathological confirmation of cutaneous T-cell lymphoma, including three with Sezary's syndrome, and twenty age matched controls was examined for soluble interleukin-2 receptor using a commercially available ELISA kit. Whilst there was no significant difference in the mean concentration of the interleukin-2 receptor between patients with mycosis fungoides and controls, six of twenty-one patients had interleukin-2 receptor levels outside the mean plus two standard deviations of the age matched cohort. Patients with Sezary's syndrome had markedly elevated levels of this receptor. Our data support a previous report suggesting serum levels of soluble interleukin-2 receptor increase with advancing age, highlighting the need for age matched controls when studying soluble interleukin-2 receptor levels in disease states.
Gilmore
S J
SJ
Department of Pathology and Immunology, Monash University, Melbourne.
Benson
E M
EM
Kelly
J W
JW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012751:Sezary Syndrome / Q000097:blood
D015375:Receptors, Interleukin-2