Effects of long-term administration of acetaminophen on the nutritional utilization of dietary protein.
The effect of long-term administration of acetaminophen to rats on the dietary protein utilization was investigated using protein-sufficient and protein-deficient diets. Fat digestibility, food efficiency and some hepatic parameters were also determined. Results showed that there was a significant decrease in the nitrogen metabolic utilization in the protein-sufficient treated animals compared to the untreated group (0.59 +/- 0.03 vs. 0.75 +/- 0.03, p less than 0.001). The protein-deficient diet and the administration of the drug resulted in lower nitrogen metabolic utilization in either of the two metabolic balances (days 4-11 and 36-42). These changes were not accompanied by variations in the nitrogen digestibility coefficient.
Varela-Moreiras
G
G
Departamento de Nutrición, Facultad de Farmacia, Universidad Complutense, Madrid, España.
Ruiz-Roso
B
B
Varela
G
G
D000082:Acetaminophen / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage / Q000378:metabolism*; D004063:Digestion / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D009747:Nutritional Physiological Phenomena / Q000187:drug effects*; D011488:Protein Deficiency / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats; D004044:Dietary Proteins; D000082:Acetaminophen; D009584:Nitrogen