[Androgen resistance related to receptor disorders].
It is the review of literature data on various phenotypic anomalies consequent to the absent or reduced ability of the target tissues to response to androgens (A) due to defects in receptor A structure and function. Clinical forms of resistance to A, quantitative and qualitative abnormalities in hormone-receptor interaction detectable in relevant patients are described as well as markers of target tissue sensitivity to A action suggested for use in prognosticating the response to A treatment.
Bezverkhaia
T P
TP
D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000188:drug therapy / Q000503:physiopathology; D000728:Androgens / Q000502:physiology / Q000627:therapeutic use*; D012734:Disorders of Sex Development / Q000188:drug therapy / Q000503:physiopathology; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007248:Infertility, Male / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D011944:Receptors, Androgen / Q000502:physiology; D013739:Testosterone / Q000502:physiology / Q000627:therapeutic use
D000728:Androgens; D011944:Receptors, Androgen; D013739:Testosterone
Rezistentnost' k androgenam, sviazannaia s narusheniem ikh retseptsii.