[The surgical and radiotherapy treatment of endometrial adenocarcinoma. A retrospective analysis of 128 patients].
From January 1980 through December 1987, 128 endometrial carcinomas were treated with combined irradiation and surgery (101 cases) or with radiotherapy alone (27 patients). Mean follow-up was 5 years (range: 2-9). Actuarial disease-free (DF) survival (according to the Kaplan and Meyer method) was 86% for T1-T2 patients, 50% for T3 cases and 35% for T4. Recurrence rate was 20% (26 patients): 9 had local recurrences, 9 nodal relapses, and 8 distant metastases. Overall side-effects were observed in only 7/128 patients (5.4%): they were grade I in 6 cases and grade II in 1. The evaluation of the prognostic factors confirms the importance of: stage (disease-free survival at 5 years: 86% for T1-T2 versus 50-35% for T3-T4); uterus size in stage T1 (DF survival at 5 years: 90% for T1A versus 70% for T1B); grading (DF survival at 5 years: 92, 87, 62% for G1, G2, G3, respectively). Myometrial infiltration seems to have no prognostic value.
Sacco
M
M
Istituto di Radiologia, Università, Torino.
Rotta
P
P
Rampino
M
M
D000230:Adenocarcinoma / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D000328:Adult; D000368:Aged; D001918:Brachytherapy; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D015994:Incidence; D008197:Lymph Node Excision; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012189:Retrospective Studies
Trattamento chirurgico e radioterapico dell'adenocarcinoma dell'endometrio. Analisi retrospettiva su 128 pazienti.