[Effects of serotonin-IA receptors on amino acid and dopaminergic responses of neurons].
By using intracellular technique the authors studied the responses of frog spinal motoneurones and rat dorsal root ganglion evoked by GABA, L-aspartate and dopamine in the presence of 5-hydroxytryptamine and its 1A-agonists or without them. It is shown that buspirone, campirone and serotonin increase the GABA effects but inhibit the effects of aspartate via the GABA- and NMDA-receptors modulation.
Abramets
I I
II
Komissarov
I V
IV
Samoĭlovich
I M
IM
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D002065:Buspirone / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D005727:Ganglia, Spinal / Q000187:drug effects*; D066298:In Vitro Techniques; D008564:Membrane Potentials; D009046:Motor Neurons / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D011898:Ranidae; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000596:Amino Acids; D011985:Receptors, Serotonin; D001224:Aspartic Acid; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D002065:Buspirone; D004298:Dopamine
Vliianie agonistov serotoninovykh-IA retseptorov na aminoatsid- i dofaminergicheskie otvety neĭronov.