[The effect of the synergistic action of enterotoxin on the specific protective complex of Shigella sonnei].
The study has first established that enterotoxin enhances the protective potency of S. sonnei specific protective complex. This effect has been revealed both in experiments of the oral immunization of mice and in experiments of the conjunctival immunization of guinea pigs and depends on the dose of enterotoxin used in the experiment. The increase of protection has a specific character. These observations open prospects for further enhancement for the protective properties of S. sonnei specific protective complex, which should be taken into consideration in developing the vaccinal preparation.
Korneeva
S A
SA
Kovalevskaia
I L
IL
D000818:Animals; D000942:Antigens, Bacterial / Q000302:isolation & purification / Q000627:therapeutic use*; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004405:Dysentery, Bacillary / Q000276:immunology / Q000517:prevention & control; D004768:Enterotoxins / Q000302:isolation & purification / Q000627:therapeutic use*; D006168:Guinea Pigs; D007114:Immunization; D007637:Keratoconjunctivitis / Q000276:immunology / Q000517:prevention & control; D051379:Mice; D012762:Shigella dysenteriae; D012764:Shigella sonnei / Q000276:immunology* / Q000472:pathogenicity; D014774:Virulence
D000942:Antigens, Bacterial; D004768:Enterotoxins
Effekt sinergentnogo deĭstviia énterotoksina na spetsificheskiĭ protektivnyĭ kompleks Shigella sonnei.