Study of the skin concentrations after administration of the various phototoxic drugs.
The skin concentrations of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), and 4, 5', 8-trimethylpsoralen (TMP) were studied in the guinea pig following oral administration and bathing. The skin concentration of phototoxic drugs after oral administration peaked at 1.5 hours, and the concentration of 8-MOP was 3.5 times greater than that of 5-MOP. The skin concentration of TMP was not detected in our study (limit of sensitivity 5ng/ml). The skin concentrations of phototoxic drug after bathing decreased in the order of 5-MOP, TMP, and 8-MOP.
Park
Y K
YK
Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
Hann
S K
SK
Cho
M Y
MY
Kim
H J
HJ
Shim
S C
SC
Choi
S J
SJ
Yun
M H
MH
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D006168:Guinea Pigs; D008730:Methoxsalen / Q000008:administration & dosage / Q000032:analysis*; D011701:PUVA Therapy; D012867:Skin / Q000737:chemistry*; D014307:Trioxsalen / Q000008:administration & dosage / Q000032:analysis*
D008730:Methoxsalen; D014307:Trioxsalen