Effect of aflatoxin B1 on human platelet protein kinase C.
1. Aflatoxin B1 serves as an activator for protein kinase C (PKC). 2. Following activation, the enzyme translocates from the cytosol to the particulate fraction. 3. Aflatoxin B1 leads to rapid and extensive phosphorylation of the known substrate of the enzyme. 4. Aflatoxin B1 causes rapid hydrolysis of phosphatidylinositol-4,5-biphosphate to diacylglycerol and inositol-1,4,5-triphosphate.
Van den Heever
L H
LH
Department of Biochemistry, R.A.U., Johannesburg, South Africa.
Dirr
H W
HW
D016604:Aflatoxin B1 / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000201:enzymology; D003720:Densitometry; D004789:Enzyme Activation; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D010766:Phosphorylation; D011493:Protein Kinase C / Q000187:drug effects*; D012995:Solubility
D016604:Aflatoxin B1; D011493:Protein Kinase C