title: Rapid development of extensive macrovascular calcifications in a type I diabetic patient.
abstract: This is a case report of a 35-year-old woman with a 15-year history of type I diabetes mellitus, who developed extensive macrovascular calcifications of the abdominal aorta and all its tributaries within 7 months of developing renal insufficiency. The patient was maintained on hemodialysis and peritoneal dialysis for a total of 3 months, then underwent combined cadaveric renal and pancreatic islet transplantation. Although some vascular calcifications are known to occur in elderly patients and in patients with long-standing uremia, it was the rapidity and extent of development of these lesions in this young woman that is astonishing.
authors.affiliation: Department of Medicine and Surgery, University of Pittsburgh, Pennsylvania 15213.
authors.forename: P B
authors.initials: PB
authors.lastname: Carroll
authors.forename: H L
authors.initials: HL
authors.lastname: Rilo
authors.forename: Y J
authors.initials: YJ
authors.lastname: Zeng
authors.forename: C
authors.initials: C
authors.lastname: Ricordi
authors.forename: R
authors.initials: R
authors.lastname: Shapiro
authors.forename: A G
authors.initials: AG
authors.lastname: Tzakis
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology* / Q000601:surgery; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy; D005260:Female; D006801:Humans; D016381:Islets of Langerhans Transplantation; D016030:Kidney Transplantation; D010530:Peritoneal Dialysis; D011859:Radiography; D006435:Renal Dialysis; D014511:Uremia / Q000150:complications / Q000503:physiopathology