[Pefloxacin pharmacokinetics in pyo-inflammatory diseases of the kidneys and urinary tract].
The factors defining the therapy efficacy were studied in 15 patients with purulent inflammatory diseases of the kidneys and urinary tract. It was found that after the use of pefloxacin, urine bactericidal properties against a pathogen was pH-dependent due to high urinary norfloxacin levels. To predict the efficacy of pefloxacin therapy in renal and urinary diseases, the pathogen should be tested for sensitivity to pefloxacin and norfloxacin within a wide range of pH values. Pefloxacin concentrations correlated with plasma bactericidal properties with respect to the pathogen and was applicable in defining the optimal treatment schemes and doses based on the data of individual drug pharmacokinetics. Monitoring of plasma and urine bactericidal properties in regard to the pathogen proved to be useful in estimating the therapy efficacy.
Lopatkin
N A
NA
Siniukhin
V N
VN
Kondrat'eva
E M
EM
Derevianko
I I
II
D001770:Blood Bactericidal Activity / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007249:Inflammation / Q000378:metabolism; D009393:Nephritis / Q000378:metabolism*; D015366:Pefloxacin / Q000493:pharmacokinetics*; D014552:Urinary Tract Infections / Q000378:metabolism*
D015366:Pefloxacin
Farmakokinetika pefloksatsina pri gnoĭno-vospalitel'nykh zabolevaniiakh pochek i mochevyvodiashchikh puteĭ.