Testing for haplotype sharing by siblings with incomplete information of parental haplotypes.
Testing for the inheritance of a disease susceptibility gene by analysis of haplotype sharing among affected siblings has been well established for the case where all four parental haplotypes have been ascertained. This paper presents a modification of a published method to cover the situation where there is incomplete information concerning parental haplotypes and this new test is applied in a worked example.
Green
J R
JR
Department of Statistics and Computational Mathematics, Liverpool University.
Grennan
D M
DM
D005260:Female; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005821:Genetic Techniques; D006239:Haplotypes; D006801:Humans; D008297:Male; D009679:Nuclear Family; D010290:Parents