title: Preparation and pharmacological activity of some 1-lupinylbenzimidazoles and 1-lupinylbenzotriazoles.
abstract: Twelve new 1-lupinyl-benzimidazole and 1-lupinyl-benzotriazole derivatives were prepared and, together with some previously described analogues, were tested for analgesic (hot plate test), antiinflammatory (against carrageenan edema), diuretic and antihypertensive (in spontaneously hypertensive rats) activities. Several compounds exhibited a good degree of activity in one or in more than one areas.
authors.affiliation: Istituto di Scienze Farmaceutiche, Università di Genova.
authors.forename: A
authors.initials: A
authors.lastname: Boido
authors.forename: I
authors.initials: I
authors.lastname: Vazzana
authors.forename: F
authors.initials: F
authors.lastname: Sparatore
authors.forename: M L
authors.initials: ML
authors.lastname: Cenicola
authors.forename: D
authors.initials: D
authors.lastname: Donnoli
authors.forename: E
authors.initials: E
authors.lastname: Marmo
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000138:chemical synthesis / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D008297:Male; D051379:Mice; D011247:Pregnancy; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011930:Reaction Time / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D001562:Benzimidazoles; D004232:Diuretics; D011807:Quinolizines; D014230:Triazoles