The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24.
FLI1 is a common mouse viral integration region in virus-induced leukemias and lymphomas. Using an evolutionarily conserved mouse probe and Southern hybridization to (rodent x human) somatic cell hybrid DNAs, the human homolog of FLI1 has been shown to lie on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.
Baud
V
V
Laboratoire de Biologie des Tumeurs, URA 1156 CNRS, Institut Gustave Roussy, Villejuif, France.
Lipinski
M
M
Rassart
E
E
Poliquin
L
L
Bergeron
D
D
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D051379:Mice; D016662:Virus Integration