Genetic control of rat T-cell response to Staphylococcus aureus enterotoxins (SE).
Rat T cells, like those of mouse and human origin, respond strongly to superantigens (SAg) derived from Staphylococcus aureus enterotoxins A and B (SEA, SEB). Lewis and ACI are high responders, whereas Brown Norway (BN) is a low responder. Congenic and back-cross rat studies indicate that the degree of responsiveness is controlled by at least one non-MHC gene. The action of these genes may reside in the antigen-presenting cells (APC), since both Sephadex G10 non-adherent BN spleen cells and purified BN T cells in the presence of Lewis APC can respond well to SE. Responses to concanavalin A (Con A) and SEA generally segregate together in back-cross rats. Surprisingly, the degree of responsiveness to Con A and SEA is not correlated with the susceptibility to experimental allergic encephalomyelitis (EAE) either in independently derived inbred rat strains or in (Lewis x BN) x BN back-cross rats.
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Department of Microbiology and Immunology, Hahnemann University, Philadelphia, PA 19102.
Villas
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Blankenhorn
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D000818:Animals; D001427:Bacterial Toxins; D003208:Concanavalin A / Q000276:immunology; D004198:Disease Susceptibility; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics / Q000276:immunology; D004768:Enterotoxins / Q000276:immunology*; D005260:Female; D008213:Lymphocyte Activation / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013211:Staphylococcus aureus / Q000276:immunology; D018089:Superantigens; D013601:T-Lymphocytes / Q000276:immunology*
D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; D003208:Concanavalin A; C026066:enterotoxin A, Staphylococcal; C031818:enterotoxin B, staphylococcal