title: Toxicity of 1,4-bis(aminocyclohexyl)methane.
abstract: 1,4-Bis(aminocyclohexyl)methane (PACM; CAS No. 1761-71-3) is a white solid considered for use in polymeric systems. PACM is moderately toxic systemically, with the acute oral lethal dose in rats between 670 and 1000 mg kg-1. PACM is a weak dermal sensitizer in the guinea pig. Instillation of as little as 10 mg of PACM to the rabbit eye produces severe injury. This damage could be permanent and was not reduced by rinsing the eye with water. Dogs given oral doses of 50 mg PACM kg-1 5 days per week for up to 18 months showed kidney and liver damage, along with local irritation of the gastrointestinal tract. The chemical is highly irritating and contact with it should be avoided.
authors.affiliation: Haskell Laboratory for Toxicology and Industrial Medicine, Central Research and Development Department, E. I. du Pont de Nemours, Inc., Newark, DE 19714.
authors.forename: G L
authors.initials: GL
authors.lastname: Kennedy
mesh_terms: D000284:Administration, Oral; D000814:Aniline Compounds / Q000633:toxicity; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003514:Cyclohexylamines / Q000633:toxicity*; D003877:Dermatitis, Contact / Q000209:etiology; D004285:Dogs; D005123:Eye / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D008297:Male; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects; D001559:Benzhydryl Compounds
chemical_list: D000814:Aniline Compounds; D002273:Carcinogens; D003514:Cyclohexylamines; C072821:1,4-bis(aminocyclohexyl)methane; C009505:4,4'-diaminodiphenylmethane; D001559:Benzhydryl Compounds