title: Endothelin-binding inhibitors, BE-18257A and BE-18257B. I. Taxonomy, fermentation, isolation and characterization.
abstract: Two endothelin (ET)-binding inhibitors, BE-18257A and BE-18257B, which antagonized 125I-ET-1 binding to a porcine aortic smooth muscle membrane, were isolated from the mycelium of a strain of Streptomyces misakiensis. These binding inhibitors were extracted with methanol from mycelium and purified by HPLC.
authors.affiliation: Exploratory Research, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kojiri
authors.forename: M
authors.initials: M
authors.lastname: Ihara
authors.forename: S
authors.initials: S
authors.lastname: Nakajima
authors.forename: K
authors.initials: K
authors.lastname: Kawamura
authors.forename: K
authors.initials: K
authors.lastname: Funaishi
authors.forename: M
authors.initials: M
authors.lastname: Yano
authors.forename: H
authors.initials: H
authors.lastname: Suda
mesh_terms: D000818:Animals; D016232:Endothelins / Q000378:metabolism*; D005285:Fermentation; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D009842:Oligopeptides / Q000302:isolation & purification* / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism; D013552:Swine
chemical_list: D016232:Endothelins; D009842:Oligopeptides; D010456:Peptides, Cyclic; C072732:cyclo(valyl-leucyl-tryptophyl-glutamyl-alanyl); C069764:cyclo(glutamyl-alanyl-isoleucyl-leucyl-tryptophyl)