title: Effect of recombinant bovine somatotropin (BST) on physiological parameters and on milk production in German Fleckvieh cows.
abstract: The efficacy of injecting primiparous cows of a dual purpose breed (Deutsches Fleckvieh) with a BST prolonged release formulation (500 mg Sometribove s.c.) was tested in a cross-over design. Seven cows were given 500 mg BST in the 10th through 19th week of lactation and a placebo in the 24th through 33rd week. A second group of seven cows received a placebo in the 10th through 19th week and BST in the 24th through 33rd week. Blood samples were taken from the jugular vein (via a permanent cannula) in the 13th, 17th, 23rd, 27th and 31st week of lactation over a period of 24 hrs at 30 min intervals. During the periods of BST treatment the amount of FCM (amount of milk corrected to 4% fat content) was higher in treated than in non-treated animals by 3.6 kg (19.8%) and 3.2 kg (22.5%) respectively. Milk fat levels were elevated significantly during both treatment periods. Milk protein concentration showed a significant rise during the second half of lactation only. There was no influence on lactose content. Blood concentration of somatotropin and IGF-I rose during treatment by a factor of 3-4. Insulin, T3, T4 and FTI as well as glucose, urea and GOT showed no changes or changes within physiological ranges. Free fatty acids and beta-hydroxybutyrate rose during treatment.
authors.affiliation: Institut für Tierzucht und Tierhygiene, Universität München.
authors.forename: F
authors.initials: F
authors.lastname: Graf
authors.forename: D
authors.initials: D
authors.lastname: Schams
authors.forename: J
authors.initials: J
authors.lastname: Meyer
authors.forename: H
authors.initials: H
authors.lastname: Kräusslich
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001947:Breeding; D002417:Cattle / Q000502:physiology*; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D007774:Lactation / Q000187:drug effects*; D008892:Milk / Q000187:drug effects; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone