title: SPECT in early- and late-onset Alzheimer's disease.
abstract: We assessed with SPECT the influence of age of onset in Alzheimer's disease in patients who were matched for severity of disease with early and late onset of the disease. Twenty-six patients, severity-matched according to scores on Mini-Mental State Examination, were compared to nine controls. Comparison of the temporoparietal cerebellar ratio (TPC) revealed a statistically significantly lower ratio in the early-onset group compared to the late-onset group of patients. These results are in agreement with other imaging, structural, and neurochemical studies, supporting the view of heterogeneity of Alzheimer's disease according to age of onset.
authors.affiliation: Department of Psychiatry, Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: H C
authors.initials: HC
authors.lastname: Weinstein
authors.forename: A
authors.initials: A
authors.lastname: Hijdra
authors.forename: E A
authors.initials: EA
authors.lastname: Van Royen
authors.forename: M M
authors.initials: MM
authors.lastname: Derix
authors.forename: G
authors.initials: G
authors.lastname: Walstra
authors.forename: C
authors.initials: C
authors.lastname: Jonker
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000523:psychology; D001921:Brain / Q000000981:diagnostic imaging*; D006801:Humans; D011569:Psychiatric Status Rating Scales; D015899:Tomography, Emission-Computed, Single-Photon