title: Milk yield of dairy cows receiving somatotropin (somavubove) daily with periodic 14-day interruption.
abstract: Thirty multiparous (cows) and 15 primiparous (heifers) lactating Holstein cattle were used in a 112-d study to examine the effects of pattern of administration of recombinantly derived bST on 3.5% FCM yield. Ten cows and 5 heifers each received either no injection (controls), 14 mg of bST daily, or four repetitions of 14 mg of bST/d for 14 d followed by 14 d of no injection (intermittent bST). Because there was an interaction between treatment groups and parity, analyses were performed separately for cows and heifers. All cows and heifers produced more FCM when given bST than controls. Comparing FCM only during the last 7 d of each period of injection for the intermittent bST group with contemporary daily injected cattle indicated that cows produced equivalent amounts of milk at those times, whereas heifers given daily bST produced 3.4 kg/d more than intermittently injected animals. Furthermore, over each of the four repetitive periods, cows and heifers given daily or intermittent bST responded similarly, although heifers given continuous bST produced more FCM than the intermittent group during each of periods 2 through 4. We conclude that daily administration of bST lends itself to dosing termination during established lactation with concomitant decline of FCM; resumption of bST allows milk yields of cows to achieve levels comparable with those prior to short-term interruption.
authors.affiliation: Upjohn Company, Kalamazoo, MI 49001.
authors.forename: E P
authors.initials: EP
authors.lastname: Stanisiewski
authors.forename: D M
authors.initials: DM
authors.lastname: Meeuwse
authors.forename: L F
authors.initials: LF
authors.lastname: Krabill
authors.forename: J W
authors.initials: JW
authors.lastname: Lauderdale
mesh_terms: D000818:Animals; D002417:Cattle / Q000502:physiology*; D004334:Drug Administration Schedule; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular / Q000662:veterinary; D007774:Lactation / Q000187:drug effects*; D016018:Least-Squares Analysis; D008892:Milk / Q000378:metabolism; D010298:Parity; D011897:Random Allocation
chemical_list: D013006:Growth Hormone