title: [Leishmania tropica in Morocco. IV--Intrafocal enzyme diversity].
abstract: Ecoepidemiological analysis of a Moroccan focus of leishmaniasis caused by Leishmania tropica revealed considerable enzymatic diversity. Seven zymodemes belonging to the complex were identified in 149 strains isolated from humans, dogs, and the vector Phlebotomus sergenti. Three distinct subgroups were identifiable, two of which were in turn, composed of three "small variant" zymodemes. The diversity appears to be related to the age of the focus, which may have allowed colonization by zymodemes of different geographic origins. Diversification into "small variants" is apparently the result of recent mutation, possibly associated with genetic exchange.
authors.affiliation: Laboratoire d'Ecologie médicale et de Pathologie parasitaire, Montpellier, France.
authors.forename: F
authors.initials: F
authors.lastname: Pratlong
authors.forename: J A
authors.initials: JA
authors.lastname: Rioux
authors.forename: J
authors.initials: J
authors.lastname: Dereure
authors.forename: J
authors.initials: J
authors.lastname: Mahjour
authors.forename: M
authors.initials: M
authors.lastname: Gallego
authors.forename: E
authors.initials: E
authors.lastname: Guilvard
authors.forename: G
authors.initials: G
authors.lastname: Lanotte
authors.forename: J
authors.initials: J
authors.lastname: Perieres
authors.forename: A
authors.initials: A
authors.lastname: Martini
authors.forename: A
authors.initials: A
authors.lastname: Saddiki
mesh_terms: D000818:Animals; D004285:Dogs; D004592:Electrophoresis, Starch Gel; D014644:Genetic Variation; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D007895:Leishmania tropica / Q000145:classification* / Q000201:enzymology / Q000235:genetics; D009018:Morocco; D010691:Phlebotomus / Q000469:parasitology; D011110:Polymorphism, Genetic
chemical_list: D007527:Isoenzymes
vernacular_title: Leishmania tropica au Maroc. IV--Diversité isozymique intrafocale.