Systemic morphine pharmacokinetics after ocular administration.
Pharmacokinetics of a single dose of morphine ocularly applied is reported in rabbits before and after lacrimal canaliculi ligature. Our investigations are based on a sensitive reversed-phase ion-pair chromatographic determination of morphine. This study describes the various resorption sites of morphine when administered through the conjunctiva. After ocular administration, morphine rapidly reaches high blood levels compatible with pharmacological activity. Ocular bioavailability of morphine is higher than after non-parenteral routes. Canaliculi ligature modifies the morphine pharmacokinetic profile without significant modification of drug bioavailability. Our results suggest a great capacity of drug resorption for the conjunctiva, and indicate the major role of nasal mucosa in physiological conditions.
Chast
F
F
Service de Pharmacie, Hôtel-Dieu de Paris, France.
Bardin
C
C
Sauvageon-Martre
H
H
Callaert
S
S
Chaumeil
J C
JC
D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D003228:Conjunctiva / Q000378:metabolism; D005260:Female; D007275:Injections, Intravenous; D007765:Lacrimal Apparatus / Q000502:physiology; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D009270:Naloxone / Q000032:analysis; D009883:Ophthalmic Solutions; D011817:Rabbits
D009883:Ophthalmic Solutions; D009270:Naloxone; D009020:Morphine