May the alterations in lipid fluidity-mediated platelet hypersensitivity contribute to accelerated aging of platelets in diabetes mellitus?
Reduced platelet membrane lipid fluidity occurring in diabetes implies that platelet membrane receptors are more exposed to the external environment. This, in turn, may result in an increased sensitivity of platelets from diabetic humans to platelet aggregating agents. Platelet hypersensitivity (PH) may lead to augmented effects of agonists on the release of amine storage granules from the platelets of diabetic individuals. Aggregating and release-inducing agents decrease platelet density, which is assumed to be relevant to the aging processes. Thus it has become commonly accepted that platelet senescence or aging contributes to platelet density heterogeneity (PDH). Alterations of dynamic parameters of platelet membranes in diabetes may thus underlie the increased rate of aging or senescence of platelets in diabetic subjects.
Watala
C
C
Department of Biophysics, University of Lòdz, Poland.
D001792:Blood Platelets / Q000473:pathology / Q000502:physiology*; D016922:Cellular Senescence; D003920:Diabetes Mellitus / Q000097:blood*; D006801:Humans; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000097:blood; D008954:Models, Biological; D010974:Platelet Aggregation
D008563:Membrane Lipids