[The immunobiological effects of nitrogranulogen. I. Effect of nitrogranulogen on laboratory and clinical parameters in patients with primary glomerulopathies].
The administration of nitrogranulogen in a dose of 0.01 mg/kg in patients with primary glomerulopathies caused a significant reduction in proteinuria in 10 out of 12 cases. In one patient the effects was striking (fall of proteinuria from 10 g/24 hrs to trace amounts). A trend towards the normalization of helper T lymphocytes (CD4+) was noted as well as a significant drop in NK lymphocytes. No side effects or drug-related complications were observed.
Rancewicz
Z
Z
Kliniki Immunoterapii, Warszawie.
Imiela
J
J
Juskowa
J
J
Małecki
R
R
Górski
A
A
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002908:Chronic Disease; D004334:Drug Administration Schedule; D005260:Female; D005922:Glomerulonephritis, IGA / Q000188:drug therapy* / Q000276:immunology / Q000652:urine; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy* / Q000276:immunology / Q000652:urine; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage*; D008875:Middle Aged; D011507:Proteinuria / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D000893:Anti-Inflammatory Agents; D008466:Mechlorethamine
Badania nad immunobiologicznym działaniem nitrogranulogenu. Cześć II. Wpływ nitrogranulogenu na parametry laboratoryjne i kliniczne u chorych z pierwotnymi glomerulopatiami.