Effects of topical application of UF-021, a novel prostaglandin derivative, on aqueous humor dynamics in normal human eyes.
The mechanism underlying the intraocular pressure (IOP) lowering effect of a prostaglandin-related compound, isopropyl 20-ethyl-9 alpha,11 alpha-dihydroxy-15-keto-cis-delta 5-prostanoate (UF-021), and its possible adverse effects in long-term use were studied in normal human eyes. A single instillation of 0.12% UF-021 significantly lowered IOP without affecting aqueous flow rate, tonographic C value or episcleral venous pressure. Protein concentration in the anterior chamber and corneal endothelial permeability to fluorescein remained unaffected. It was suggested that UF-021 lowers IOP mainly by increasing uveoscleral outflow. Twice daily application of 0.12% UF-021 for 4 weeks caused no significant changes in aqueous protein concentration, aqueous flow rate or corneal endothelial permeability. Neither single nor long-term use of topical UF-021 induced irritative responses in the outer segment of the eye. The present study suggests that UF-021 has potential as a safe and effective ocular hypotensive drug with a mechanism of action different from other drugs currently available for the treatment of glaucoma.
Sakurai
M
M
Department of Ophthalmology, University of Tokyo School of Medicine, Japan.
Araie
M
M
Oshika
T
T
Mori
M
M
Masuda
K
K
Ueno
R
R
Takase
M
M
D000287:Administration, Topical; D000328:Adult; D000867:Anterior Chamber / Q000378:metabolism; D001082:Aqueous Humor / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000494:pharmacology; D004728:Endothelium, Corneal / Q000378:metabolism; D005136:Eye Proteins / Q000032:analysis; D015590:Fluorophotometry; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D010539:Permeability; D011680:Pupil / Q000187:drug effects; D011897:Random Allocation; D012590:Sclera / Q000098:blood supply; D014065:Tonometry, Ocular
D005136:Eye Proteins; C072630:isopropyl unoprostone; D015237:Dinoprost