[Determination of trace chloride and sulfate in drugs by ion chromatography].
Chloride and sulfate in magnesium trisilicate, activated charcoal, vesnarinone and bendazac were determined by the IC conductimetric detection. Analysis were performed by using a separating column (100 x 6 mm i.d.) packed with anion exchanger and with a stripper column (100 x 6 mm i.d.); 1.4 mmol/L Na2CO3 and 1.4 mmol/L Na2CO3-0.75 mmol/L NaHCO3 were used as eluents respectively. The peak height was linear with concentration from 10(-6) to 10(-3) mol/L for Cl- and from 10(-5) to 10(-3) mol/L for SO4(2-). Results showed no significant difference as compared with those determined by the CHP (1985) and CHP (1990) appendices methods. The IC method is specific, sensitive, simple and rapid.
Zhou
Z
Z
Department of Analytical Chemistry, School of Pharmacy.
Wu
C
C
Zhang
Q
Q
Luo
F
F
D002606:Charcoal / Q000032:analysis; D002712:Chlorides / Q000032:analysis*; D002852:Chromatography, Ion Exchange; D008274:Magnesium / Q000032:analysis*; D017633:Magnesium Silicates; D011719:Pyrazines; D011804:Quinolines / Q000032:analysis; D012824:Silicic Acid / Q000032:analysis*; D013431:Sulfates / Q000032:analysis*
D002712:Chlorides; D017633:Magnesium Silicates; D011719:Pyrazines; D011804:Quinolines; D013431:Sulfates; D012824:Silicic Acid; D002606:Charcoal; C041667:vesnarinone; C001671:magnesium trisilicate; D008274:Magnesium