Recovery of denervated muscle receptors following treatments to accelerate nerve regeneration.
Nerve regeneration promoters offer the possibility of enhancing recovery following nerve injury by increasing the numbers of regenerating axons and decreasing the period of tissue denervation. To date, recent studies have concentrated on evaluating the action of such promoters on the nerve itself and on the restoration of motor function. This study examines afferent regeneration by evaluating the recovery of muscle spindles and tendon organs after nerve injury and treatment with alpha-melanocyte stimulating hormone or nerve stimulation. Treatment was found to be effective in enhancing short-term recovery after nerve-crush injury in terms of increasing the rate of functional and morphological recovery. Following nerve section, there was an increase in the number of reinnervating axons compared with control values.
Scott
J J
JJ
Department of Physiology, University of Leicester, U.K.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D002415:Cats; D004558:Electric Stimulation; D006614:Hindlimb / Q000294:innervation; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology; D009121:Muscle Denervation; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D010543:Peroneal Nerve / Q000502:physiology; D011984:Sensory Receptor Cells / Q000502:physiology*
D009074:Melanocyte-Stimulating Hormones