Effect of prostaglandin E1 on renal haemodynamics in a patient with diabetic nephropathy.
A 66-year old male with severe hyperglycaemia due to previously uncontrolled diabetes mellitus was also suffering from arteriosclerosis obliterans and diabetic nephropathy. The patient was treated with 16 IU/day insulin zinc suspension. In addition, an intravenous infusion of 80 micrograms/day prostaglandin E1 was given for 28 days in an attempt to improve the arteriosclerosis obliterans and diabetic nephropathy. Treatment resulted in a reduction in fasting blood glucose but no decline in urinary protein. Prostaglandin E1 treatment, however, produced an improvement in renal haemodynamics assessed by renography.
Okada
S
S
Third Department of Medicine, Okayama University Medical School, Japan.
Ogino
Y
Y
Ichiki
K
K
Tanokuchi
S
S
Ishii
K
K
Hamada
H
H
Ota
Z
Z
Hiraki
Y
Y
D000368:Aged; D000527:Alprostadil / Q000494:pharmacology*; D001162:Arteriosclerosis Obliterans / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D001786:Blood Glucose / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D011507:Proteinuria / Q000378:metabolism
D001786:Blood Glucose; D000527:Alprostadil