title: [The lithium concentration of the blood plasma in combined therapy with lithium carbonate and carbamazepine].
abstract: In view of the fact that therapy of affective psychoses with the combination of lithium carbonate with carbamazepine has been becoming ever common, the question arises about the influence of carbamazepine on plasma lithium concentration. On the material of 125 blood samples by using the method of dispersion analysis it was shown that carbamazepine exerts no effect on this parameter. Therefore when carbamazepine is added to lithium therapy it is not advisable to decrease lithium dose as it can result in a reduction of the therapeutic effect.
authors.forename: A I
authors.initials: AI
authors.lastname: Skorik
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy; D002220:Carbamazepine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008094:Lithium / Q000097:blood*; D016651:Lithium Carbonate / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000097:blood / Q000188:drug therapy; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy
chemical_list: D016651:Lithium Carbonate; D002220:Carbamazepine; D008094:Lithium
vernacular_title: Kontsentratsiia litiia v plazme krovi pri kombinirovannoĭ terapii karbonatom litiia i karbamazepinom.