title: Chloro----hydroxy substitution on technetium BATO [TcCl(dioxime)3 BR] complexes.
abstract: The neutral, seven coordinate complexes of technetium known as the BATO (Boronic acid Adducts of Technetium diOximes) complexes have shown their utility as myocardial and cerebral perfusion agents. The axial chloride ligand of the BATO complexes [99mTcCl(dioxime)3 BR] is labile to substitution by a competitive anion; under physiological conditions, the axial chloride ligand can be replaced by a hydroxy group. The chloro and hydroxy analogs have different biodistributions and single-pass cerebral extraction efficiencies. The influence of structure on the rate of the in vitro chloro/hydroxy exchange process has been studied. The mechanism of axial ligand exchange was found to be SN1-CB, which proceeds by way of a transient, neutral six coordinate complex. Evidence is presented which indicates that chloro/hydroxy exchange is not the mechanism by which BATO complexes are retained in the brain.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903.
authors.forename: S S
authors.initials: SS
authors.lastname: Jurisson
authors.forename: W
authors.initials: W
authors.lastname: Hirth
authors.forename: K E
authors.initials: KE
authors.lastname: Linder
authors.forename: R J
authors.initials: RJ
authors.lastname: Di Rocco
authors.forename: R K
authors.initials: RK
authors.lastname: Narra
authors.forename: D P
authors.initials: DP
authors.lastname: Nowotnik
authors.forename: A D
authors.initials: AD
authors.lastname: Nunn
mesh_terms: D000818:Animals; D001897:Boronic Acids; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging; D002712:Chlorides / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006878:Hydroxides / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D010091:Oximes; D011877:Radionuclide Imaging; D051381:Rats; D012039:Regional Blood Flow; D013667:Technetium
chemical_list: D001897:Boronic Acids; D002712:Chlorides; D006878:Hydroxides; D008024:Ligands; D010091:Oximes; D013667:Technetium