An objective perspective on recombinant hirudin: a new anticoagulant and antithrombotic agent.
Leeches have been in medical use for many years. Hirudin, the anticoagulant obtained from the medicinal leech has been purified, characterized and can now be produced by recombinant (r) technology. R-hirudin is a potent inhibitor of thrombin and is therefore a potentially valuable anticoagulant and antithrombotic drug. This article reviews the current status of r-hirudin in this role and compares the pharmacokinetics, mechanism of action and clinical efficacy of this agent with heparin. The methods available for laboratory assessment and clinical monitoring of r-hirudin and the possible ways of antagonizing its effects are also discussed. Finally, the potential clinical applications of r-hirudin are outlined, although further laboratory and clinical studies, together with a fall in the cost of this compound are required before r-hirudin can be more widely accepted as an anticoagulant and antithrombotic agent.
Fareed
J
J
Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153.
Walenga
J M
JM
Iyer
L
L
Hoppensteadt
D
D
Pifarre
R
R
D000595:Amino Acid Sequence; D000818:Animals; D001777:Blood Coagulation; D001792:Blood Platelets / Q000187:drug effects; D004341:Drug Evaluation; D005343:Fibrinolytic Agents / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000627:therapeutic use; D024764:Hirudin Therapy; D006629:Hirudins / Q000031:analogs & derivatives* / Q000032:analysis / Q000235:genetics / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D008969:Molecular Sequence Data; D011183:Postoperative Complications / Q000517:prevention & control; D011994:Recombinant Proteins / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D013917:Thrombin / Q000037:antagonists & inhibitors; D013927:Thrombosis / Q000517:prevention & control
D005343:Fibrinolytic Agents; D006629:Hirudins; D011994:Recombinant Proteins; D006493:Heparin; D013917:Thrombin; C060225:desirudin