A prospective comparison between magnetic resonance imaging, meta-iodobenzylguanidine scintigraphy and marrow histology/cytology in neuroblastoma.
A prospective comparison between magnetic resonance imaging (MRI), 123I meta-iodobenzylguanidine (mIBG) scintigraphy and posterior iliac crest marrow aspiration and trephine biopsy in 30 assessments (19 patients) showed concordance between the three techniques in 16 assessments (53.3%). In 10 (33.3%), MRI and mIBG revealed abnormalities not detected by marrow biopsy. MRI was the only technique to demonstrate marrow abnormality in four assessments (13.3%). In addition, MRI revealed more sites of abnormality in 16 parallel assessments. We conclude that MRI shows promise as a non-invasive means of detecting bone marrow infiltration by neuroblastoma, but that further evaluation of the specificity of MRI in this setting is indicated.
Corbett
R
R
Department of Paediatrics, Royal Marsden Hospital, Sutton, Surrey, U.K.
Olliff
J
J
Fairley
N
N
Moyes
J
J
Husband
J
J
Pinkerton
R
R
Carter
R
R
Treleaven
J
J
McElwain
T
T
Meller
S
S
D019797:3-Iodobenzylguanidine; D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology*; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007462:Iodobenzenes; D008279:Magnetic Resonance Imaging; D008297:Male; D009447:Neuroblastoma / Q000000981:diagnostic imaging / Q000473:pathology*; D011446:Prospective Studies; D011877:Radionuclide Imaging
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine