Fifty years of amanitin.
Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far. The main toxin, alpha-amanitin, is in constant use as a tool in molecular biology and in biological research. First experiments have been reported in which amanitin bound to polymers could be internalized into tumor cells via a receptor-mediated endocytosis.
Wieland
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T
Max-Planck-Institut für Medizinische Forschung, Heidelberg, Germany.
Faulstich
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H
D000546:Amanitins / Q000737:chemistry / Q000266:history* / Q000633:toxicity; D000818:Animals; D049673:History, 20th Century; D006801:Humans; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000633:toxicity; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects
D000546:Amanitins; D010456:Peptides, Cyclic; D012319:RNA Polymerase II