[Estimate of the prevalence of tuberculosis infection among vaccinated school-children by the Bhattacharya's method].
The successful application of Bhattacharya's method (decomposition of frequency distribution into normal components by a graphic method) in the analysis of the results of tuberculin test performed on a population sensitized by "anonymous" strains of mycobacteria, suggested the possibility of its application to two samples of BCG vaccinated school-children, living in the city of S. Paulo (Brazil). One of the sample groups, vaccinated between the second and seventh years of life, was surveyed in 1982 and the other, vaccinated during the first year of life, was surveyed in 1988. In both populations it was possible to characterize the normal component corresponding to children infected by tuberculous bacilli and to quantify them. In the first one, the average size of the reactions was 17.40 mm, the standard deviation 3.72 mm and the proportion of infected children 7.71%, against 4.85% in the unvaccinated control group; otherwise, in the population surveyed in 1988, the average size was 17.00 mm, the standard deviation 4.67 mm and the proportion of infected children amounted to 4.14% against 4.48% in the control group. It is concluded that the method permits the estimation of the prevalence of tuberculosis infection among BCG-vaccinated school-children, provided that the vaccine has been given during the first year of life.
Arantes
G R
GR
Departamento de Epidemiologia, Faculdade de Saúde Pública da Universidade de São Paulo, Brasil.
Nardy
S M
SM
Nogueira
P A
PA
Belluomini
M
M
Weiler
R M
RM
D001500:BCG Vaccine / Q000008:administration & dosage*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D006801:Humans; D016011:Normal Distribution; D012680:Sensitivity and Specificity; D014374:Tuberculin Test; D014376:Tuberculosis / Q000453:epidemiology* / Q000276:immunology
D001500:BCG Vaccine
Estimativa da prevalência de infecção tuberculosa em escolares vacinados com BCG, por meio de método de Bhattacharya.