Detection of anti-ovarian antibodies by indirect immunofluorescence in patients with premature ovarian failure.
The sera of 30 patients with premature ovarian failure (POF) and a control group of 19 menopausal women were screened for anti-ovarian and other tissue antibodies. Anti-ovarian antibodies were detected by indirect immunofluorescence using monkey ovary substrates from two different commercial sources. Serum anti-ovarian antibodies were detected in only one of the patients with POF. This test does not appear to be reliable for the detection of serum anti-ovarian antibodies, and the clinical usefulness of screening patients with POF for anti-ovarian antibodies is questionable.
Kirsop
R
R
Department of Obstetrics and Gynaecology, Kolling Institute of Medical Research, St Leonards, NSW, Australia.
Brock
C R
CR
Robinson
B G
BG
Baber
R J
RJ
Wells
J V
JV
Saunders
D M
DM
D000311:Adrenal Glands / Q000276:immunology; D000328:Adult; D000906:Antibodies / Q000032:analysis*; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006386:Hemagglutination Tests; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000276:immunology*; D010295:Parietal Cells, Gastric / Q000276:immunology; D016649:Primary Ovarian Insufficiency / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology
D000906:Antibodies; D000974:Antibodies, Antinuclear