Age-related changes in memory and their pharmacologic modulation.
A passive avoidance procedure was used to measure the ability to learn and remember to avoid a noxious stimulus in 13-month-old mice and to test the effects that treatment with cytidine(5')-diphosphocholine (CDP-choline) had on these processes. Half of the mice received 500 mg/kg per day CDP-choline orally for 4 months, and the two groups were compared with a third group of younger animals (4-month-old mice). The older mice showed marked impairment in the execution of these tests; however, those treated with CDP-choline had significant improvement in their performance 24 hours after learning the task.
Agut
J
J
Centro de Investigación Grupo Ferrer, Barcelona, Spain.
Ortiz
J A
JA
D000375:Aging; D000544:Alzheimer Disease / Q000188:drug therapy / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology* / Q000627:therapeutic use; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains
D003566:Cytidine Diphosphate Choline