[Factor D of complement: Uremic toxin?].
Factor D is an essential enzyme of the alternative pathway of complement. Its catabolism is mainly renal. The concentration of factor D increases with renal failure, and is approximately 10-fold higher in patients with end-stage renal disease. The accumulation of factor D is responsible for an enhancement of alternative pathway activation. Whether this excess of factor D has pathophysiological consequences remains to be determined, however, complement activation might participate in adverse effects during hemodialysis and in the progression of renal injury.
Pascual
M
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D011416:Complement Factor D / Q000378:metabolism*; D003170:Complement Pathway, Alternative; D006801:Humans; D014511:Uremia / Q000378:metabolism*
C493488:CFD protein, human; D011416:Complement Factor D
Le facteur D du complément: toxine urémique?