Distinctions in DNA and protein profiles among clinical isolates of Mycoplasma pneumoniae.
Clinical isolates of Mycoplasma pneumoniae previously shown to exhibit significant sequence divergency in a major 170 kDa adhesin, designated P1, were further characterized using restriction enzyme fingerprinting of genomic DNA and two-dimensional gel electrophoresis of total proteins. Numerous differences in DNA restriction patterns and protein profiles were found, possibly reflecting various degrees of virulence and antigenic potential.
Su
C J
CJ
Department of Microbiology, University of Texas Health Science Center, San Antonio 78284-7758.
Dallo
S F
SF
Alderman
H
H
Baseman
J B
JB
D001426:Bacterial Proteins / Q000235:genetics*; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics*; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D009177:Mycoplasma pneumoniae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification
D001426:Bacterial Proteins; D004269:DNA, Bacterial