Persistence of systemic mastocytosis after allogeneic bone marrow transplantation in spite of complete remission of the associated myelodysplastic syndrome.
A myelodysplastic syndrome (MDS), type 5 (RAEB-t), and systemic mastocytosis affecting the spleen, the splenic lymph nodes, the bone marrow and the liver were diagnosed in a 38-year-old woman. The clinical course was complicated by splenic vein thromboses and iliac artery embolism. The thrombotic episodes might be secondary to mast cell mediator release. A complete remission of the MDS was obtained by allogeneic bone marrow transplantation, but the mastocytosis persisted. Thus, the possibility that the mast cell originates from a common myeloid precursor cell may be questioned.
Rønnov-Jessen
D
D
Department of Haematology, Gentofte Hospital, Hellerup, Denmark.
Løvgreen Nielsen
P
P
Horn
T
T
D000328:Adult; D016026:Bone Marrow Transplantation; D004617:Embolism / Q000150:complications; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D007083:Iliac Artery; D008407:Mast Cells / Q000473:pathology; D008415:Mastocytosis / Q000150:complications / Q000473:pathology / Q000601:surgery*; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000473:pathology / Q000601:surgery*; D013162:Splenic Vein; D013924:Thrombophlebitis / Q000150:complications