title: The effect of restraint stress on the kinetics, magnitude, and isotype of the humoral immune response to influenza virus infection.
abstract: The stress of physical restraint has been shown to modulate the cellular immune response during a viral infection. We have studied the effects of stress on the humoral immune response during infection by influenza virus. Restraint stress altered the kinetics of the antibody response; seroconversion in the IgG and IgA isotypes was delayed in virus-infected C57BL/6 mice subjected to repeated cycles of physical restraint. However, the magnitude and isotype of the mature antibody response were unaffected during the plateau phase; no significant differences were observed between restrained/infected and nonrestrained/infected mice. Thus, the time during infection at which the antibody response was measured was a significant variable in the study of stress-induced alterations of the host's response to a replicating viral antigen. While restraint stress did not significantly affect the magnitude or class of the humoral response, it did alter the kinetics of response.
authors.affiliation: Department of Medical Microbiology, Ohio State University College of Medicine, Columbus 43210.
authors.forename: N
authors.initials: N
authors.lastname: Feng
authors.forename: R
authors.initials: R
authors.lastname: Pagniano
authors.forename: C A
authors.initials: CA
authors.lastname: Tovar
authors.forename: R H
authors.initials: RH
authors.lastname: Bonneau
authors.forename: R
authors.initials: R
authors.lastname: Glaser
authors.forename: J F
authors.initials: JF
authors.lastname: Sheridan
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis; D009980:Influenza A virus / Q000276:immunology*; D007700:Kinetics; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D008954:Models, Biological; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes