Effect of sodium nitrite on myocardial glutathione peroxidase and protective action of vitamin E and selenium.
Under the condition of acute NaNO2 poisoning, the changes of myocardial GSH-Px activity of rats fed a diet composed of grains grown in the endemic region of Keshan disease and the same diet with supplementation of vitamin E or selenium were investigated. By gavage of toxic doses of NaNO2, the myocardial GSH-Px was significantly reduced (P less than 0.05). Vitamin E or selenium supplementation protected the enzyme activity from reducing. It is suggested that the simultaneous action of an increase in selenium and vitamin E intake and a decrease in nitrite intake might greatly prevent the occurrence of Keshan disease.
Yang
Q
Q
Institute of Endemic Disease, Norman Bethune University of Medical Sciences, Changchun, Jilin, China.
Wang
F
F
D000818:Animals; D009202:Cardiomyopathies / Q000378:metabolism* / Q000517:prevention & control; D005979:Glutathione Peroxidase / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D012643:Selenium / Q000627:therapeutic use*; D012977:Sodium Nitrite / Q000506:poisoning*; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E; D005979:Glutathione Peroxidase; D012643:Selenium; D012977:Sodium Nitrite