[Prolonged antibacterial action of polymer coated suture materials].
The antimicrobial activity of capromed, a surgical polymer-coated sutural material containing dioxidine, quinoxidine or gentamicin was studied in vitro and in vivo. Capromed was shown to be active against the hospital strains of S. aureus, E. coli, Proteus spp., Klebsiella spp. and P. aeruginosa. The antimicrobial activity of ADH and AG threads was preserved for 3 to 4 days after implantation. The DH-2 and G-2 threads preserved their activity for 6 to 7 days. It was concluded that the duration of thread antimicrobial activity depended on the properties of the polymer coating the thread. Capromed was applied to 280 operation wounds in 275 patients. There was no wound suppuration in the group of patients after pure operations (n = 62). In the group of patients after conditionally pure operations (n = 130) suppuration was observed in 2 patients (1.3 per cent). In patients with contaminated wounds (n = 88) suppuration in 5 of them (5.7 per cent) was recorded. The total number of the purulent complications after using capromed in surgical operations amounted to 2.5 per cent. In the control group purulent complications were stated in 8.2 per cent of the cases.
Aleksandrov
K R
KR
Volenko
A V
AV
Vasina
T A
TA
Sidorova
I V
IV
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D005839:Gentamicins / Q000008:administration & dosage; D008826:Microbial Sensitivity Tests; D009757:Nylons / Q000494:pharmacology; D011108:Polymers; D011810:Quinoxalines / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013537:Sutures; D013997:Time Factors
D000891:Anti-Infective Agents, Local; C060170:Capromed DC; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D005839:Gentamicins; D009757:Nylons; D011108:Polymers; D011810:Quinoxalines; C003286:quinoxidine; C001077:dioxidine
Prolongirovannoe antibakterial'noe deĭstvie shovnykh materialov s polimernym pokrytiem.