title: Decrease of frontal metabolism demonstrated by positron emission tomography in a population of healthy elderly volunteers.
abstract: Frontal metabolism measured with positron emission tomography is shown to be decreased relatively to that in other cortical or sub-cortical areas, in a population of healthy elderly compared to young volunteers. Cortical atrophy or neuronal depopulation are unlikely to entirely explain this physiological phenomenon, and sub-cortico-cortical deactivation should play a role, analogous to that proposed in subcortical diseases.
authors.affiliation: Department of Neurology, University of Liège, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Salmon
authors.forename: P
authors.initials: P
authors.lastname: Maquet
authors.forename: B
authors.initials: B
authors.lastname: Sadzot
authors.forename: C
authors.initials: C
authors.lastname: Degueldre
authors.forename: C
authors.initials: C
authors.lastname: Lemaire
authors.forename: G
authors.initials: G
authors.lastname: Franck
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D003847:Deoxyglucose / Q000031:analogs & derivatives; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose