Single sc administration of insulin-like growth factor I (IGF-I) in normal men.
Total and free form of IGF-I in plasma increased in a dose dependent manner after sc IGF-I administration. Peak values of total IGF-I were obtained at 3-4 h after the administration, and then the values decreased gradually. However, peak values of free form of IGF-I were obtained at 2 h, and then rapidly decreased thereafter. The blood glucose, serum insulin and C-peptide levels decreased until 4 h after IGF-I administration in a dose dependent manner. Plasma IGF-II values significantly decreased at 4-12 h after IGF-I administration. Urinary urea nitrogen and sodium excretion decreased after IGF-I administration. Urinary GH excretion also decreased after 0.06 mg/kg IGF-I administration. These data demonstrate that IGF-I may play a role in glucose, protein and electrolyte metabolism, and plasma IGF-II levels and GH secretion might be regulated by IGF-I in man.
Hizuka
N
N
Department of Medicine, Tokyo Women's Medical College, Japan.
Takano
K
K
Asakawa
K
K
Fukuda
I
I
Sukegawa
I
I
Shizume
K
K
Demura
H
H
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood / Q000187:drug effects; D004573:Electrolytes / Q000652:urine; D013006:Growth Hormone / Q000652:urine; D006801:Humans; D007279:Injections, Subcutaneous; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D009584:Nitrogen / Q000652:urine; D011863:Radioimmunoassay; D012016:Reference Values
D001786:Blood Glucose; D002096:C-Peptide; D004573:Electrolytes; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D009584:Nitrogen