title: Necrotizing eccrine squamous syringometaplasia presenting as acral erythema.
abstract: Acral erythema (AE) and eccrine squamous syringometaplasia (ESS) are distinctive clinico-pathological entities described in patients receiving chemotherapy for malignancies, mainly myelogenous leukemia. In no case of chemotherapy-induced AE have histopathologic changes of ESS been described. We report a patient with acute myelogenous leukemia who had typical AE due to cytarabine with histopathologic ESS. The latter findings in a case of AE may be a useful diagnostic clue for distinguishing chemotherapy-induced AE from palmo-plantar erythema of graft-vs-host reaction.
authors.affiliation: Department of Dermatology, University of Genoa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Rongioletti
authors.forename: A
authors.initials: A
authors.lastname: Ballestrero
authors.forename: F
authors.initials: F
authors.lastname: Bogliolo
authors.forename: A
authors.initials: A
authors.lastname: Rebora
mesh_terms: D000328:Adult; D003561:Cytarabine / Q000009:adverse effects / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004439:Eccrine Glands / Q000473:pathology*; D004890:Erythema / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D006229:Hand Dermatoses / Q000175:diagnosis*; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008297:Male; D008679:Metaplasia / Q000473:pathology; D009336:Necrosis / Q000473:pathology; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000175:diagnosis* / Q000473:pathology
chemical_list: D003561:Cytarabine