The effects of interleukin-1 beta on the activity of adrenal, splenic and renal sympathetic nerves in the rat.
The effects of intravenous (i.v.) administration of recombinant human interleukin-1 beta (rhIL-1 beta) on the activity of adrenal, splenic and renal sympathetic nerves were observed in urethane-anesthetized rats. An i.v. injection of IL-1 beta in doses of 10 pg-20 ng per animal (300-400 g, b.w.) resulted in a dose-dependent increase in the activity of the adrenal and splenic nerves, which lasted for more than 2-6 h. On the other hand, the activity of renal nerves showed a transient increase which was followed by a long-lasting suppression after injection of rhIL-1 beta (100 pg, i.v.). An i.v. injection of cyclooxygenase inhibitors (6 mg ibuprofen or 20 mg sodium salicylate) suppressed almost completely the rhIL-1 beta (100 pg)-induced activity in adrenal and splenic nerves. Although rhIL-1 beta (100 pg, i.v.) produced a fall in arterial blood pressure, baroreceptor denervation did not affect the excitatory responses of the adrenal and splenic nerves to rhIL-1 beta. The results suggest the regional differentiation of activity in the visceral sympathetic nerves in response to rhIL-1 beta. The rhIL-1 beta-induced activation of splenic sympathetic nerves implicates their involvement in the modulation of immunity by brain.
Niijima
A
A
Department of Physiology, Niigata University School of Medicine, Japan.
Hori
T
T
Aou
S
S
Oomura
Y
Y
D000311:Adrenal Glands / Q000294:innervation*; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology; D007375:Interleukin-1 / Q000494:pharmacology*; D007668:Kidney / Q000294:innervation*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009476:Neurons, Efferent / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D012980:Sodium Salicylate / Q000494:pharmacology; D013154:Spleen / Q000294:innervation*; D013564:Sympathetic Nervous System / Q000187:drug effects*
D007375:Interleukin-1; D011994:Recombinant Proteins; D012980:Sodium Salicylate; D007052:Ibuprofen