[The blood anticoagulant system in rats perorally administered a heparin-acetylsalicylic acid complex].
Heparin/acetylsalicylate complexes (1:9 and 10:1) were obtained in vitro. Single or chronic (7-8 days) per os administration to white rats of 0.1% solution of the heparin/acetylsalicylate complex (0.3 ml/200 g body weight) enhanced anticoagulative properties of blood plasma, increased the fibrinolytic activity in respect of stabilized fibrin, and diminished the thrombin-induced platelet aggregation.
Kudriashov
B A
BA
Liapina
L A
LA
Pastorova
V E
VE
Kondashevskaia
M V
MV
D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage*; D001777:Blood Coagulation / Q000187:drug effects*; D004338:Drug Combinations; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000008:administration & dosage*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D004338:Drug Combinations; D006493:Heparin; D001241:Aspirin
Sostoianie protivosvertyvaiushcheĭ sistemy krovi krys pri peroral'nom vvedenii kompleksa geparin--atsetilsalitsilovaia kislota.