Low-osmolality contrast media: dosage comparison of ioversol and iohexol for cranial computed tomography.
One hundred patients undergoing cranial computed tomography were evaluated in this prospective, randomized, double-blind comparative study. Patients received 50 mL of ioversol 320 (16 g iodine), 75 mL of ioversol 320 (24 g iodine), 100 mL of iohexol 240 (24 g iodine), 100 mL of iohexol 300 (30 g iodine) or 150 mL of iohexol 240 (36 g iodine). Twenty patients were enrolled in each treatment group. No patient in any treatment group experienced any contrast-media-related adverse reaction. Results of this study coupled with our prior work suggests that the lowest dose and optimal concentration of low-osmolality contrast media necessary to produce diagnostic cranial computed tomography is 32 g of iodine administered in a concentration of 320 mg/100 mL iodine.
Kuhn
M J
MJ
Southern Illinois University School of Medicine, Springfield 62769.
Long
S D
SD
DeSio
M A
MA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000008:administration & dosage* / Q000191:economics; D003365:Costs and Cost Analysis; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage*; D008297:Male; D009994:Osmolar Concentration; D011446:Prospective Studies; D011856:Radiographic Image Enhancement / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000008:administration & dosage*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C054871:ioversol