title: Characterization of iodine derivatives of aflatoxin B1 and G1 by thermospray mass spectrometry.
abstract: Thermospray mass spectrometry (TSMS) was used to identify the derivatives formed when iodine is reacted with aflatoxins B1 and G1 at approximately 70 degrees C to enhance fluorescence. It was found that stable derivatives were formed by addition of an iodine atom and a methoxy group across the double bond located on the furan ring of the aflatoxin B1 and G1 molecules. TSMS and TSMS/MS daughter spectra of the reaction products of aflatoxin B1 and G1 with iodine provide evidence of the addition of each moiety to produce the iodo-methoxy derivative. The addition of an iodine atom to one carbon and a methoxy group to the other carbon of the furan ring provided molecular weights of 470 and 486 for the products of aflatoxin B1 and G1, respectively.
authors.affiliation: Food and Drug Administration, Division of Chemistry, Jefferson, Arkansas 72079.
authors.forename: M
authors.initials: M
authors.lastname: Holcomb
authors.forename: W A
authors.initials: WA
authors.lastname: Korfmacher
authors.forename: H C
authors.initials: HC
authors.lastname: Thompson
mesh_terms: D016604:Aflatoxin B1 / Q000031:analogs & derivatives / Q000032:analysis* / Q000737:chemistry; D000348:Aflatoxins / Q000032:analysis* / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D013058:Mass Spectrometry
chemical_list: D000348:Aflatoxins; C027955:aflatoxin G1; D007455:Iodine; D016604:Aflatoxin B1