[The importance of plasma lipids and apolipoproteins in the assessment of risk of myocardial infarction in the most common types of primary hyperlipoproteinemias].
In a group of 60 men after myocardial infarction (IM) with primary hyperlipoproteinaemia (HLP), type IIA, IIB and IV the authors revealed on comparison with a control group of 71 men with similar types of HLP where ischaemic heart disease (IHD) was not detected, significantly higher concentrations of total plasma cholesterol (TC), low density lipoproteins (LDL-C), apolipoprotein (apo)B in LDL; in the hyperlipidaemic subjects after IM the concentration of HDL-C was significantly lower as well as the ratio of cholesterol and apo-B in the LDL fraction. In patients with hypercholesterolaemia (HLP IIA and IIB) for estimation of the risk of IHD LDL-C, HDL-C and apo-B in LDL are useful. In patients with hypertriglyceridaemia (HLP IIB and IV) subjects with a history of IM have in addition to a higher concentration of apo-B in LDL a lower ratio of cholesterol to apo-B in LDL and in those with HLP IV also a lower plasma concentration of apo-A-I. By the discriminating function the variable of which is in HLP IIB the apo-B concentration in LDL and in HLP IV apo-B in LDL and apo-A-I in plasma in HLP IIB 77.8% subjects and in HLP IV 82.9% subjects with an increased risk of IHD can be detected.
Zeman
M
M
IV. interní klinika 1. lékarské fakulty Univerzity Karlovy, Praha.
Zák
A
A
Vítková
D
D
Dusek
F
F
D001053:Apolipoproteins / Q000097:blood*; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood* / Q000150:complications; D008055:Lipids / Q000097:blood*; D008297:Male; D009203:Myocardial Infarction / Q000097:blood*; D012307:Risk Factors
D001053:Apolipoproteins; D008055:Lipids
Význam plazmatických lipidů a apolipoproteinů pri stanovení rizika infarktu myokarkdu u nejcastĕjsích typů primárních hyperlipoproteinémií.