title: Intravitreal U75412E: a new free radical scavenger.
abstract: Free-radical-mediated tissue damage is thought to be involved in a multitude of ophthalmic pathologies. Therefore, drugs that scavenge free radicals may find wide clinical application. A new chemical class of antiinflammatory agents, the 21-aminosteroids, has been developed as free radical scavengers. These agents are thought to inhibit lipid peroxidation and prevent the release of free arachidonic acid from injured cell membranes. In the present study, we investigated the intraocular toxicity of one of the 21-aminosteroids, U75412E. Intravitreal doses of up to 0.1 mg of U75412E were nontoxic to rabbit ocular tissues.
authors.affiliation: Department of Ophthalmology, UIC Eye Center, Chicago 60612.
authors.forename: R
authors.initials: R
authors.lastname: Fiscella
authors.forename: D A
authors.initials: DA
authors.lastname: Gagliano
authors.forename: N S
authors.initials: NS
authors.lastname: Peachey
authors.forename: R
authors.initials: R
authors.lastname: Feist
authors.forename: R
authors.initials: R
authors.lastname: Dunn
authors.forename: T T
authors.initials: TT
authors.lastname: Lam
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000633:toxicity*; D003623:Dark Adaptation; D004596:Electroretinography / Q000187:drug effects; D016166:Free Radical Scavengers; D009336:Necrosis; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D013256:Steroids / Q000633:toxicity*; D014822:Vitreous Body / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D013256:Steroids; C069980:U 75412E