The C5 isozyme of serum cholinesterase and adult weight.
The relationship between the CHE2 locus of serum cholinesterase (BChE) and adult human weight was studied in a sample of 225 CHE2 C5+ individuals and 225 CHE2 C5- controls matched for sex, height, age and race. With respect to the intensity of the C5 band staining (scored 1-6), 113 individuals had faint C5 bands (scores 1-3) and 112 intense C5 bands (scores 4-6). The individuals with intense CHE2 C5+ phenotype showed a significantly lower mean adult weight (64.66 +/- 0.73 kg) when compared to their controls (70.59 +/- 0.97 kg) and a significant reduction in weight variance (59.81 and 105.18, respectively). Individuals with faint C5 bands, although showing a negative correlation between weight and C5 band intensity, did not differ from their controls in mean weight.
Chautard-Freire-Maia
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EA
Department of Genetics, Federal University of Paraná, Curitiba, Brazil.
Primo-Parmo
S L
SL
Picheth
G
G
Lourenço
M A
MA
Vieira
M M
MM
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D001835:Body Weight / Q000235:genetics*; D002091:Butyrylcholinesterase / Q000097:blood / Q000235:genetics*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012044:Regression Analysis
D007527:Isoenzymes; D002091:Butyrylcholinesterase