[Adaptation of the body to stress effects increases resistance of nuclear DNA of cardiac cells due to accumulation of heat shock proteins in the nucleus].
It was shown that adaptation to stress exposure increased the resistance of nuclear DNA in myocardial cells to the damaging action of exogenous one-chain DNA (50 micrograms/ml). This protective effect was accompanied by a pronounced accumulation of heat shock proteins (hsp) 70 in nucleoplasm of myocardial cells from adapted animals. Possible mechanism of the DNA protective effect of adaptation and the role of hsp 70 are under discussion.
Malyshev
I Iu
IIu
Zamotrinskiĭ
A V
AV
Meerson
F Z
FZ
D000222:Adaptation, Physiological; D000818:Animals; D004247:DNA / Q000032:analysis* / Q000737:chemistry; D004277:DNA, Single-Stranded / Q000494:pharmacology; D006360:Heat-Shock Proteins / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*
D004277:DNA, Single-Stranded; D006360:Heat-Shock Proteins; D004247:DNA
Adaptatsiia organizma k stressornym vozdeĭstviiam povyshaet ustoĭchivost' iadernoĭ DNK serdechnykh kletok za schet nakopleniia belkov teplovogo shoka v iadre.