title: Platelet adhesion to a biomimetic prosthesis prepared from canine arterial wall.
abstract: A biomimetic prosthesis was prepared from canine arterial wall by extraction with 70% formic acid. Under these conditions, the arterial architecture consisting of elastic lamella was conserved and the tensile strength was retained. Attachment of 51Cr-endothelial cells to the surface of the prosthesis was enhanced in the presence of collagen (50 micrograms/ml), fibronectin (20 micrograms/ml), and fibrinogen (500 micrograms/ml). These agents also enhanced the adhesion of 51Cr-platelets. However, preattachment of endothelial cells to prostheses prevented platelet adhesion.
authors.affiliation: Second Department of Surgery, Tokyo Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Magari
authors.forename: H
authors.initials: H
authors.lastname: Fukushima
authors.forename: S
authors.initials: S
authors.lastname: Ishimaru
authors.forename: K
authors.initials: K
authors.lastname: Furukawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yagyu
authors.forename: T
authors.initials: T
authors.lastname: Takano
mesh_terms: D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D001807:Blood Vessel Prosthesis; D004285:Dogs; D004548:Elasticity; D004730:Endothelium, Vascular / Q000166:cytology; D005561:Formates; D006083:Graft Occlusion, Vascular / Q000517:prevention & control; D007083:Iliac Artery / Q000187:drug effects / Q000502:physiology; D008855:Microscopy, Electron, Scanning; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010973:Platelet Adhesiveness / Q000502:physiology*; D011474:Prosthesis Design; D013718:Tensile Strength
chemical_list: D000085:Acetates; D005561:Formates; C030544:formic acid; D019342:Acetic Acid