[Effects of the removal of the epiphysis on the hypnogenic action of hexanal in rats].
After pinealectomy a potentiation of the hypnogenic effect of hexobarbital sodium was observed in rats, which was particularly expressed during night hours. Melatonin (0.1 mg/kg, i.p.) attenuated but not fully eliminate this effect. As suggested pineal compounds have an antihypnogenic activity which can be of a pharmacokinetic and pharmacodynamic origin.
Arushanian
E B
EB
Votvev Orkhiĭ
P
P
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D002940:Circadian Rhythm; D006591:Hexobarbital / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology* / Q000601:surgery; D012621:Seasons
D000447:Aldehydes; C010463:n-hexanal; D006591:Hexobarbital; D008550:Melatonin
Vliianie udaleniia épifiza na gipnogennoe deĭstvie geksenala u krys.