Chewing gum and lozenges as delivery systems for noscapine.
Chewing gum and lozenges were evaluated as delivery systems for noscapine with the aim of developing improved antitussive preparations. The formulations studied were prepared with both the water-soluble hydrochloride salt of noscapine and with the poorly soluble embonate salt and noscapine free base. The release characteristics of the preparations were evaluated both in vitro and in vivo, and their taste properties examined. Only the formulations containing noscapine base were without any appreciable taste. Chewing gum containing this compound showed, however, a low level of drug release both in vitro and in vivo and is therefore not a suitable dosage form. Only a lozenge formulation containing noscapine base fulfilled the requirements of taste acceptability and adequate release properties.
Jensen
L N
LN
Royal Danish School of Pharmacy, Department of Pharmaceutics, Copenhagen.
Christrup
L L
LL
Menger
N
N
Bundgaard
H
H
D002638:Chewing Gum; D004337:Drug Carriers; D006801:Humans; D009665:Noscapine / Q000008:administration & dosage*; D012995:Solubility; D013607:Tablets
D002638:Chewing Gum; D004337:Drug Carriers; D013607:Tablets; D009665:Noscapine