Diuretic profile of a novel loop diuretic torasemide in rats and dogs.
In the present study, the authors have examined the diuretic action of a novel loop diuretic torasemide and compared it to those of other diuretics, employing normal rats and dogs. Oral administration of torasemide elicited a dose-dependent increase in urine volume and electrolyte excretion, and elevated the urinary Na/K ratio in rats. These effects were more potent than those of the other diuretics furosemide, trichlormethiazide, indapamide and spironolactone. Moreover, torasemide exhibited a similar or higher urinary Na/K ratio than the combination of these diuretics and spironolactone. In a study employing anaesthetized dogs, i.v. injection of torasemide resulted in a higher urinary Na/K ratio in comparison to furosemide, in addition to potent and long-lasting diuretic activity.
Uchida
T
T
Central Research Laboratory, Green Cross Corporation, Osaka, Japan.
Ohtaki
Y
Y
Kido
H
H
Watanabe
M
M
D000758:Anesthesia; D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013148:Spironolactone / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*; D000077786:Torsemide
D004232:Diuretics; D013449:Sulfonamides; D013148:Spironolactone; D000077786:Torsemide