[Flomoxef in the pediatric surgical field].
Basic and clinical studies of flomoxef (6315-S, FMOX) were performed in the pediatric surgical field. The results obtained are summarized as follows: 1. FMOX was administered to 7 pediatric patients with biliary atresia (FMOX 20 mg/kg, i.v.d.). Peak biliary levels of FMOX were obtained at 1 hour after finishing administration by drip infusion, and were higher than those in blood 1 hours after finishing administration by drip infusion. 2. Urinary excretion was excellent, and urinary recovery rates were 57.8-97.8%. 3. FMOX was administered to 5 patients in the pediatric surgical field. One case was phlegmon, and other 4 cases were premature babies for postoperative prophylactic use. Clinical results were excellent in 1 case, good in 4 cases, with an overall efficacy rate of 100%. No clinical and laboratory side effects due to the administration FMOX were observed. It was concluded that FMOX was a safe and effective antibiotic in the pediatric surgical field.
Yura
J
J
First Department of Surgery, Nagoya City University Medical School.
Shimizu
Y
Y
Hashimoto
T
T
Nakamura
T
T
Otobe
Y
Y
Minami
M
M
D000367:Age Factors; D001424:Bacterial Infections / Q000517:prevention & control*; D001646:Bile / Q000378:metabolism; D001656:Biliary Atresia / Q000378:metabolism; D002481:Cellulitis / Q000188:drug therapy*; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication
D002511:Cephalosporins; C045693:flomoxef