title: Effect of prostaglandin E1 on renal haemodynamics in a patient with diabetic nephropathy.
abstract: A 66-year old male with severe hyperglycaemia due to previously uncontrolled diabetes mellitus was also suffering from arteriosclerosis obliterans and diabetic nephropathy. The patient was treated with 16 IU/day insulin zinc suspension. In addition, an intravenous infusion of 80 micrograms/day prostaglandin E1 was given for 28 days in an attempt to improve the arteriosclerosis obliterans and diabetic nephropathy. Treatment resulted in a reduction in fasting blood glucose but no decline in urinary protein. Prostaglandin E1 treatment, however, produced an improvement in renal haemodynamics assessed by renography.
authors.affiliation: Third Department of Medicine, Okayama University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: Y
authors.initials: Y
authors.lastname: Ogino
authors.forename: K
authors.initials: K
authors.lastname: Ichiki
authors.forename: S
authors.initials: S
authors.lastname: Tanokuchi
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Hamada
authors.forename: Z
authors.initials: Z
authors.lastname: Ota
authors.forename: Y
authors.initials: Y
authors.lastname: Hiraki
mesh_terms: D000368:Aged; D000527:Alprostadil / Q000494:pharmacology*; D001162:Arteriosclerosis Obliterans / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D001786:Blood Glucose / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D011507:Proteinuria / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D000527:Alprostadil