Antibodies to hepatocyte derived antigens and liver damage in patients after bone marrow transplantation.
The follow-up sera from 33 patients who received allogenic bone marrow transplantation (BMT) were tested by ELISA for antibodies to liver derived antigens present in a macromolecular, lipid associated, protein complex (LSP). Anti-LSP were found in 20% of patients with graft-vs-host disease (1 with acute GVHD, 3 with chronic GVHD), but in none of the 13 patients without GVHD. Lymphocytotoxic antibodies (LCTA) were frequently detected with similar prevalence in patients with and without GVHD. In the 4 anti-LSP +ve cases, LCTA serum levels did not follow the trend of anti-LSP antibody levels. Liver biopsy was performed in 10 patients with clinical and biochemical sign of GVHD and showed features of hepatic GVHD in six cases; although piecemeal necrosis was present in 3 cases, anti-LSP were detected only in one patient. An anti-LSP response can be elicited in patients after BMT only during GVHD, with no relationship to LCTA and without a close association with signs of periportal hepatocyte damage.
Borzì
R M
RM
I Patologia Medica, Università di Bologna, Italy.
Meliconi
R
R
Conte
R
R
Bandini
G
G
Ricci
P
P
Miglio
F
F
Facchini
A
A
Gasbarrini
G
G
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000097:blood*; D000961:Antilymphocyte Serum / Q000032:analysis; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000276:immunology* / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D011506:Proteins / Q000276:immunology*
D000906:Antibodies; D000961:Antilymphocyte Serum; D008565:Membrane Proteins; D011506:Proteins