title: Phenoxymethylpenicillin two or three times daily for tonsillitis with beta-haemolytic streptococci group A: a blinded, randomized and controlled clinical study.
abstract: In relation to compliance problems it was investigated whether phenoxymethylpenicillin dosed twice or 3 times daily was equally effective in tonsillitis due to beta-haemolytic streptococci group A. In a randomized, controlled and single blind multicentre study 206 patients older than 5 years with a positive culture of group A streptococci were treated with phenoxymethylpenicillin for 7 days. 101 patients received the daily dosage divided in 2 doses and 105 patients divided in 3 doses a day. The cure rate (a combination of bacteriological and clinical cure) was 82.0% in the 2-dosage regimen, and 88.2% in the 3-dosage regimen. The difference was not statistically significant. In conclusion, phenoxymethylpenicillin dosed 2 or 3 times daily seems to be equally effective in tonsillitis due to group A streptococci.
authors.affiliation: Medical Department, Apothekernes Laboratorium AS, Oslo, Norway.
authors.forename: G
authors.initials: G
authors.lastname: Fyllingen
authors.forename: A R
authors.initials: AR
authors.lastname: Arnesen
authors.forename: C
authors.initials: C
authors.lastname: Biermann
authors.forename: O
authors.initials: O
authors.lastname: Kaarby
authors.forename: O
authors.initials: O
authors.lastname: Romfo
authors.forename: J
authors.initials: J
authors.lastname: Rønnevig
authors.forename: J
authors.initials: J
authors.lastname: Aaserud
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009664:Norway; D010404:Penicillin V / Q000008:administration & dosage* / Q000627:therapeutic use; D016037:Single-Blind Method; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013297:Streptococcus pyogenes; D014069:Tonsillitis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D010404:Penicillin V