Extrapolating from toxicity data to occupational exposure limits: some considerations.
This paper evaluates procedures relevant to extrapolating from toxicity data in man and animals to Occupational Exposure Limits. It examines effects at or around the "No Observed Adverse Effect Level' (NOAEL) and the magnitude of safety factors which can be applied in developing occupational exposure limits for non-stochastic effects. The relationship between incidence of stochastic effect and occupational exposure limit is also discussed.
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D002985:Clinical Protocols / Q000592:standards*; D003663:Decision Trees; D004353:Drug Evaluation, Preclinical / Q000706:statistics & numerical data*; D015987:Effect Modifier, Epidemiologic; D015438:Health Behavior; D006801:Humans; D008452:Maximum Allowable Concentration; D015233:Models, Statistical; D016273:Occupational Exposure; D012449:Safety; D014116:Toxicology / Q000379:methods / Q000592:standards*