title: Familial dysalbuminemic hyperthyroxinemia associated with multinodular goiter and elevated radioiodine uptake. A case report.
abstract: Familial dysalbumenic hyperthyroxenemia characterized by elevations in serum total thyroxine (T4) and free-thyroxine index and normal free T4 and radioiodine uptake has been previously described. This syndrome is secondary to an autosomal dominant inheritance in which affected individuals are mistakenly diagnosed as thyrotoxic because of the elevation of serum levels of total T4 and free T4. The excess T4 level is caused by the presence of an abnormal serum protein that binds excess T4, thereby raising the level of total T4. The authors report the case of a patient with familial dysalbumenic hyperthyroxenemia who presented with superimposed multinodular goiter and an elevated 24-hour radioiodide uptake.
authors.affiliation: Department of Radiology, Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas 78234.
authors.forename: M O
authors.initials: MO
authors.lastname: Toney
authors.forename: J D
authors.initials: JD
authors.lastname: Heironimus
mesh_terms: D000368:Aged; D005260:Female; D006044:Goiter, Nodular / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D006981:Hyperthyroxinemia / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D007457:Iodine Radioisotopes; D011877:Radionuclide Imaging; D012709:Serum Albumin / Q000378:metabolism*; D013577:Syndrome
chemical_list: D007457:Iodine Radioisotopes; D012709:Serum Albumin