Effects of saikosaponin-d on the functions and morphology of macrophages.
The effects of saikosaponin-d, isolated from Bupleurum Radix, on phagocytosis and spreading of mouse peritoneal macrophages were investigated. Macrophages from saikosaponin-d-treated mice showed a significant increase in spreading activity followed by an increase in phagocytic activity. An intense distribution of microfilaments and microtubules was also observed in these macrophages by immunofluorescence microscopy.
Ushio
Y
Y
Research Institute of Oriental Medicine, Kinki University, Osaka, Japan.
Abe
H
H
D000818:Animals; D002465:Cell Movement; D003599:Cytoskeleton / Q000187:drug effects; D007273:Injections, Intramuscular; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008856:Microscopy, Fluorescence; D008858:Microscopy, Phase-Contrast; D009024:Morphogenesis; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010533:Peritoneal Lavage; D010587:Phagocytosis / Q000187:drug effects; D012502:Sapogenins / Q000302:isolation & purification / Q000494:pharmacology*; D012503:Saponins
D012502:Sapogenins; D012503:Saponins; D009828:Oleanolic Acid; C025759:saikosaponin D