title: Dietary taurine content changes liver lipids in cats.
abstract: Adult female cats were fed a completely defined purified diet (taurine-free) alone or containing 0.05% taurine (the normal dietary requirement) or 1% taurine (20-fold the normal dietary requirement) for greater than 2 y. The relative composition of conjugated biliary bile acids was not different among the three groups and virtually all bile acids were conjugated with taurine. The taurine concentration in liver varied dramatically with the amount of taurine in the diet. Total liver lipid content decreased with increasing dietary taurine. Individual lipid components also varied, especially free fatty acids (which decreased with increasing dietary taurine) and triglycerides (which increased with increasing dietary taurine), indicating that taurine has a metabolic effect on lipid metabolism. Taurine deficiency also caused significant changes in the fatty acid distribution of sphingomyelin. In particular, a decrease of lignoceric acid and an increase of nervonic acid were observed. The present data suggest that hepatocellular levels of taurine can modulate the mobilization of liver lipid stores and the utilization by the liver of circulating free fatty acids. These effects are probably mediated by factors affecting membrane fluidity, such as the ratio of cholesterol to phospholipids, the degree of unsaturation of phospholipids and the changes in sphingomyelin fatty acid composition.
authors.affiliation: Laboratory of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanita, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cantafora
authors.forename: I
authors.initials: I
authors.lastname: Blotta
authors.forename: S S
authors.initials: SS
authors.lastname: Rossi
authors.forename: A F
authors.initials: AF
authors.lastname: Hofmann
authors.forename: J A
authors.initials: JA
authors.lastname: Sturman
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002415:Cats; D005227:Fatty Acids / Q000302:isolation & purification; D005260:Female; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D013654:Taurine / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D005227:Fatty Acids; D013654:Taurine