title: Treatment of acute soft tissue trauma with a topical non-steroidal anti-inflammatory drug (biphenylacetic acid 3% gel).
abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to be effective in the treatment of acute soft tissue injuries. However, taken orally, NSAIDs have a definite incidence of gastro-intestinal toxicity. Since acute soft tissue trauma is normally localised, use of a topical NSAID may eliminate this undesirable side-effect. This study was designed to evaluate the efficacy and safety of a topical NSAID, biphenylacetic acid 3% gel (Traxam) in the treatment of soft tissue trauma. Thirty-two patients (22 males and 10 females) with acute soft tissue trauma were enrolled at the Department of Orthopaedic Surgery, National University Hospital, Singapore from 7 June 1988 to 28 March 1989. Each patient was treated for a period of one week with bipenylacetic acid 3% gel (Traxam), 60 mg three times a day. Statistically significant improvement was found in pain, swelling and functional impairment in all patients assessed at day 3 and day 7 after the injury. The speed of recovery was enhanced. The medication was found to be well tolerated and safe.
authors.affiliation: Department of Orthopaedic Surgery, National University Hospital, Singapore.
authors.forename: E H
authors.initials: EH
authors.lastname: Lee
authors.forename: P Y
authors.initials: PY
authors.lastname: Lee
authors.forename: A T
authors.initials: AT
authors.lastname: Ngai
authors.forename: E H
authors.initials: EH
authors.lastname: Chiu
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003288:Contusions / Q000188:drug therapy*; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D010648:Phenylacetates / Q000008:administration & dosage*; D013180:Sprains and Strains / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D010648:Phenylacetates; C012776:biphenylylacetic acid