title: Transient myocardial perfusion abnormalities during cold provocation test in patients with arterial hyperreactivity.
abstract: The effect of peripheral cold provocation on myocardial perfusion was evaluated utilizing thallium-201 perfusion imaging in 13 selected patients with arterial hyperreactivity (Raynaud's phenomenon: n = 8; migraine: n = 6) and angiographically documented coronary artery spasm. Eleven out of 13 subjects with coronary arterial spasm--but none of a group of patients with obstructive coronary artery disease--had transient myocardial perfusion defects during cold provocation. The localization of transient perfusion abnormalities during myocardial scintigraphy correlated with the myocardial areas distal to the spontaneous or ergonovine-induced coronary arterial spasm detected by angiography. Transient reduction of tracer uptake during cold provocation and normalization of myocardial perfusion by redistribution imaging was paralleled by areas of hypokinesia observed during the test by contrast ventriculography (n = 8). The described findings in the coronary system during peripheral cold pressor test occurred independently of the presence of Raynaud's phenomenon, and without achieving the ischemic threshold.
authors.affiliation: Kardiologische Universitätsklinik Wien, Osterreich.
authors.forename: T
authors.initials: T
authors.lastname: Stefenelli
authors.forename: H
authors.initials: H
authors.lastname: Sochor
authors.forename: B
authors.initials: B
authors.lastname: Slama
authors.forename: J
authors.initials: J
authors.lastname: Czernin
authors.forename: O
authors.initials: O
authors.lastname: Pachinger
authors.forename: P
authors.initials: P
authors.lastname: Probst
mesh_terms: D000328:Adult; D000368:Aged; D003080:Cold Temperature; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000000981:diagnostic imaging*; D004874:Ergonovine / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D011928:Raynaud Disease / Q000000981:diagnostic imaging*; D013794:Thallium Radioisotopes
chemical_list: D013794:Thallium Radioisotopes; D004874:Ergonovine