Autoregulation of cochlear blood flow. A comparison of cerebral blood flow with muscular blood flow.
The cochlear blood flow of healthy adult guinea pigs was measured with a laser Doppler flowmeter and flow dynamics were analyzed on the basis of autoregulation. Angiotensin II infusion was used to raise blood pressure, while phlebotomy was done to lower blood pressure. The characteristics of autoregulation of cerebral blood flow and muscular blood flow were also investigated. Cochlear blood flow was considered to have some autoregulation but was less than brain blood flow, which showed significant regulation. Muscular blood flow seemed to have no similar regulatory mechanism.
Kawakami
M
M
Department of Otolaryngology, Osaka Medical College, Japan.
Makimoto
K
K
Fukuse
S
S
Takahashi
H
H
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001815:Bloodletting; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003051:Cochlea / Q000098:blood supply*; D006168:Guinea Pigs; D006706:Homeostasis; D008406:Masseter Muscle / Q000098:blood supply*; D012039:Regional Blood Flow / Q000502:physiology
D000804:Angiotensin II