Pregnancy-associated idiopathic intrahepatic cholestasis. Hypotheses of physiopathology: a therapeutic case report.
By modification of the circulating pool of biliary acids, the administration of ursodesoxycholic acid has permitted the restoration of normal maternal hepatic function during a triple pregnancy complicated by the precocious onset of an intrahepatic cholestasis. The marked regression in clinical and biological markers of the disease confirms the role of biliary acids in the aggravation of hepatic abnormalities.
Marpeau
L
L
Service du Prof. J. Barrat, Clinique Gynécologie Obstétrique, Paris, France.
Chazouillière
O
O
Rhimi
Z
Z
Poupon
R
R
Pigne
A
A
Barrat
J
J
D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism; D002780:Cholestasis, Intrahepatic / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D004967:Estrogens / Q000502:physiology; D005260:Female; D006801:Humans; D008954:Models, Biological; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000503:physiopathology*; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D001647:Bile Acids and Salts; D004967:Estrogens; D014580:Ursodeoxycholic Acid