An antiviral sesquiterpene hydroquinone from the marine sponge Strongylophora hartmani.
A new sesquiterpene hydroquinone 1, which we call strongylin A, was isolated from the marine sponge Strongylophora hartmani. Its structure was determined through spectroscopic methods, including 2D-13C homonuclear correlation spectroscopy (INADEQUATE). Both 1 and its acetate derivative are active in in vitro assays against the P-388 tumor cell line and influenza strain PR-8.
Wright
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Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Ft. Pierce, FL 34946.
Rueth
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Cross
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D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification; D002460:Cell Line; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009975:Orthomyxoviridae / Q000187:drug effects; D011161:Porifera; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D012717:Sesquiterpenes; C073085:strongylin A