[The effect of a combination of N-propylajmaline bromide and trimecaine on heart arrhythmias of different origins and on the electrophysiological parameters of the myocardium].
In experiments on dogs and cats with disorders of the atrial and ventricular rhythms of various genesis the combination of N-propylaymalinebromide and trimecaine (the antiarrhythmic drugs of classes IA and IB) was found to potentiate the antiarrhythmic action. This effect was studied in electrophysiological experiments by using the microelectrode technique or on the dog and rat myocardium tissue. The combination of the antiarrhythmic drugs was shown to exert a more significant effect on some electrophysiological parameters determining the arrhythmic readiness of the myocardium.
Gendenshteĭn
E I
EI
Balashov
V P
VP
Sosunov
E A
EA
Kostin
Ia V
IaV
Oleĭnikov
V E
VE
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D002415:Cats; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D011219:Prajmaline / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D014288:Trimecaine / Q000494:pharmacology / Q000627:therapeutic use*
D011219:Prajmaline; D014288:Trimecaine
Vliianie kombinatsii N-propilaĭmalinbromida i trimekaina na aritmii serdtsa raznogo geneza i élektrofiziologicheskie parametry miokarda.