title: Asymmetrical effects of albumin on transsynovial fluid movement.
abstract: The effect of intraarticular infusions of albumin solution on transsynovial flow was studied in healthy rabbit knee joints and compared with the effect of albumin solution perfused through the synovial microcirculation. Increasing intravascular albumin levels enhanced fluid absorption from the joint cavity, whereas increasing intraarticular albumin levels reduced the absorption rate. The slope of intraarticular pressure-versus-absorption rate plots was reduced by albumin in proportion to the reduction in fluidity (1/viscosity). When joint pressure was held constant, the transsynovial absorption rate was reduced by albumin in excess of the fluidity reduction and even reversed to filtration into the joint cavity. Thus intraarticular albumin acts by a dual mechanism, namely by increasing synovial interstitial fluid viscosity and by exerting a peri-capillary oncotic pressure. However, the latter effect was much less than that of intravascular albumin. Reasons for this are discussed.
authors.affiliation: Department of Physiology, St George's Hospital Medical School, London, England.
authors.forename: J R
authors.initials: JR
authors.lastname: Levick
authors.forename: J N
authors.initials: JN
authors.lastname: McDonald
authors.forename: A D
authors.initials: AD
authors.lastname: Knight
mesh_terms: D000042:Absorption; D000818:Animals; D003102:Colloids / Q000493:pharmacokinetics; D007260:Infusion Pumps; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000378:metabolism / Q000502:physiology; D009994:Osmolar Concentration; D009997:Osmotic Pressure; D011312:Pressure; D011817:Rabbits; D012709:Serum Albumin / Q000494:pharmacology / Q000502:physiology*; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D003102:Colloids; D012709:Serum Albumin