[Evaluation of interleukin-2 soluble receptor in patients with trypanosomiasis americana in Panama].
The quantitative determination of Interleukin-2 Receptor (sIL-2R) in the serum of patients with acute or chronic Chagas disease is compared with values found in normal individuals. The mean value of soluble IL-2R in patients with acute Chagas' disease was found to be 3,282 +/- 171 U/ml. The mean value of sIL-2R in serum samples from chronic chagasic patients was 511 +/- 207 U/ml, while in the control or "normal" group of persons the mean value for sIL-2R was 366 +/- 108 u/ml. In patients with early or acute infections with T. cruzi, the serum levels of sIL-2R was usually above 1000 u/ml. However, the correlation with anti-T. cruzi antibodies and levels of sIL-2R was not always directly proportional. Specific antibodies anti-T. cruzi in serum from chronic chagasic patients, shown at low or high levels, did not reveal a proportional correlation with serum levels of sIL-2R which tend to be significantly lower than in early or acute infections. It is considered that high values for sIL-2R are related with the parasite activity and its pathologic interaction with the host. It is possible that high levels of sIL-2R could serve as an indicator of early or acute Chagas' disease and be useful in assessment of disease conditions and response to therapy.
Pascale
J M
JM
Centro de Investigación y Diagnostico de Enfermedades Parasitarias (CIDEP), Facultad de Medicina, Universidad de Panamá.
Sosa
C E
CE
Orn
A
A
D014355:Chagas Disease / Q000097:blood*; D006801:Humans; D010176:Panama; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D015375:Receptors, Interleukin-2
Evaluación del receptor soluble de interleucina--2 en pacientes con Tripanosomiasis Americana en Panamá.