[Metabolism of thyroid gland cells as affected by prolactin and emotional-physical stress].
A study was made of the role of prolactin (PRL) in the regulation of thyroid function in intact animals and in those exposed to stress (swimming was used as physical exercise). A single daily dose of 125 micrograms of PRL per 100 g of body mass was injected subcutaneously in 0.5 ml of saline solution during a week to male rats (control: intact rats; injection of 0.5 ml of saline solution subcutaneously). Redox enzymes; succinate dehydrogenase, lactate dehydrogenase, glucose-6-phosphate dehydrogenase, NAD.H2 and NADP.H2, ATPase and monoamine oxidase, total protein, RNA and glycogen in glandular cells were investigated histochemically 24 h after the last injection of PRL or saline, 30 min., 1, 2, 3, 5 and 7 hours after swimming or right after complete fatigue (in the presence of experimental hyperprolactinemia). A conclusion has been made that one of the most important mechanisms of the adaptive effect of PRL is its ability to suppress thyroid function, thus decreasing the metabolism level, which results in reduction of oxygen consumption and improves body tolerance to stress.
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D000818:Animals; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D011388:Prolactin / Q000502:physiology*; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism*; D013961:Thyroid Gland / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*
D011388:Prolactin
Metabolizm kletok shchitovidnoĭ zhelezy pod vliianiem prolaktina i émotsional'no-fizicheskogo stressa.