[Polycythemia vera with der(15) and der(20) associated with remarkable neutrophilia].
An autopsy case of polycythemia vera with der(15) and der(20) associated with remarkable neutrophilia was reported. A 87-year-old man was diagnosed as polycythemia vera in August 1987. The red blood cell count was 621 x 10(4)/microliters, Ht 58.5% and the white blood cell count 45,400/microliters with 92% neutrophils. The splenomegaly, increased red blood cell volume and the low erythropoietin level were present. The arterial SaO2 value was above 92%. The chromosome analysis of bone marrow cells revealed 46, XY, -15, -20, +der(15)t(15;?)(q13-15;?), +der(20)t(20;?)(q11;?). The breakpoint in No. 20 was in q11. The remarkable leukocytosis with relative and absolute neutrophilia were observed. Particularly late in the clinical course the white blood cell count was 92,900/microliters with 99% neutrophils. The Ph1 chromosome was negative and the bcr rearrangement was not detected. He died of bronchopneumonia in January 1989. At the autopsy findings neither the marrow fibrosis nor the extramedullary leukemic cell infiltration was noticed.
Tanaka
S
S
Division of Hematology, Shizuoka City Hospital.
Yokota
R
R
Mochizuki
T
T
Nohgawa
M
M
Maeda
A
A
Ito
T
T
D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002884:Chromosomes, Human, Pair 15; D002890:Chromosomes, Human, Pair 20; D006801:Humans; D007964:Leukocytosis / Q000209:etiology*; D008297:Male; D009504:Neutrophils; D011087:Polycythemia Vera / Q000150:complications / Q000235:genetics*