The use of microwave oven for the rapid hydrolysis of bile acid methyl esters.
An efficient and convenient procedure for the hydrolysis of bile acid methyl esters is described. This is achieved by the addition of aqueous lithium hydroxide in methanol/dioxane/tetrahydrofuran (or dimethylformamide) in the microwave oven. Under these conditions the formates as well as the acetate derivatives prepared under microwave irradiation conditions were also hydrolyzed, and the desired bile acids were isolated in 86-94% yield. All these reactions were completed in the microwave oven within 45-60 s.
Dayal
B
B
Department of Medicine, UMDNJ-New Jersey Medical School, Newark 07103.
Salen
G
G
Dayal
V
V
D001647:Bile Acids and Salts / Q000737:chemistry*; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004952:Esters; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008872:Microwaves; D015394:Molecular Structure
D001647:Bile Acids and Salts; D004952:Esters