Cytotoxic effects of a new antitumor antibiotic, FK973, in malignant glioma.
A novel antitumor antibiotic, 11-acetyl-8-carbamoyloxymethyl-4-formyl-14-oxa-1, 11-diazatetracyclo [7.4.1.0(2,7).0(10,12] tetradeca-2,4,6-trien-6,9-diyl diacetate, FK973, was obtained as a fermentation product from Streptomyces sandaensis. This drug showed excellent cytotoxic effects on human glioblastoma and medulloblastoma and murine glioma (203 glioma) cells. The antitumor effects were also observed in ACNU-resistant glioma cells. The median survival time (MST) of MG models was 15 days. When they were treated with FK973, their MST was prolonged to 21 days. FK973 showed no apparent damage to murine brain cells.
Moriuchi
S
S
Department of Neurosurgery, Osaka University Medical School, Japan.
Shimizu
K
K
Yamada
M
M
Mabuchi
E
E
Tamura
K
K
Park
K C
KC
Hayakawa
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D001932:Brain Neoplasms / Q000188:drug therapy*; D003561:Cytarabine / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005333:Fetus; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D008527:Medulloblastoma / Q000188:drug therapy*; D008727:Methotrexate / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D016685:Mitomycin / Q000494:pharmacology; D010078:Oxazines / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010078:Oxazines; D003561:Cytarabine; C054974:FK 973; D016685:Mitomycin; D004317:Doxorubicin; D008727:Methotrexate