Studies of the quenching phenomenon in delayed contact hypersensitivity reactions.
Studies in guinea pig and man have shown that eugenol can quench non-specifically contact urticarial responses, whereas limonene seems largely ineffective. In a comprehensive series of studies, there was little evidence of quenching of delayed contact hypersensitivity reactions to cinnamic aldehyde or citral, including in 'pre-quenched' material supplied by a perfume/flavour company, and in a similar mixture prepared in this laboratory, in the guinea pig model. In addition, there was no evidence of the quenching by eugenol of allergic reactions to cinnamic aldehyde in a panel of human subjects with a proven history of cinnamic-aldehyde-induced allergic contact dermatitis. Overall, the results lend little credibility to earlier literature reports of quenching phenomena in delayed contact hypersensitivity responses.
Basketter
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DA
Environmental Safety Laboratory, Sharnbrook, Bedford, England.
Allenby
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CF
D000171:Acrolein / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D000328:Adult; D000368:Aged; D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology / Q000276:immunology*; D004195:Disease Models, Animal; D005054:Eugenol / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects
D010476:Perfume; D005054:Eugenol; D000171:Acrolein; C012843:cinnamaldehyde