title: Malignant pineal teratomas: a report on three patients and the case for craniospinal irradiation following chemotherapy.
abstract: Malignant pineal teratomas carry a poor prognosis. We describe a long-term survivor after chemotherapy and craniospinal irradiation, and another who achieved only transient disease control with chemotherapy and cranial irradiation. Spinal cord spread occurred in first patient and long-term survivors have been reported following surgery and craniospinal irradiation alone, suggesting a role for craniospinal irradiation following chemotherapy.
authors.affiliation: Beatson Oncology Centre, Western Infirmary, Glasgow, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Senan
authors.forename: R
authors.initials: R
authors.lastname: Rampling
authors.forename: S B
authors.initials: SB
authors.lastname: Kaye
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D002648:Child; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005260:Female; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D010870:Pineal Gland / Q000528:radiation effects* / Q000601:surgery; D011379:Prognosis; D013116:Spinal Cord / Q000528:radiation effects; D013120:Spinal Cord Neoplasms / Q000532:radiotherapy; D015996:Survival Rate; D013724:Teratoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome