title: Attenuation of the pressor response to tracheal intubation by magnesium sulphate with and without alfentanil in hypertensive proteinuric patients undergoing caesarean section.
abstract: The pressor response to tracheal intubation is known to be exaggerated in patients with gestational proteinuric hypertension (GPH). We have studied the effect of pretreatment with magnesium sulphate 40 mg kg-1 or 30 mg kg-1 with alfentanil 7.5 micrograms kg-1 on this pressor response in 38 patients with moderate to severe GPH. The magnesium-alfentanil combination produced better control of arterial pressure and heart rate than magnesium alone, although both techniques provided good cardiovascular control. There was no significant difference in fetal outcome between groups. Both pretreatment methods produced satisfactory control of catecholamine release.
authors.affiliation: Department of Anaesthesia, University of Cape Town, Medical School, Observatory, S. Africa.
authors.forename: W B
authors.initials: WB
authors.lastname: Ashton
authors.forename: M F
authors.initials: MF
authors.lastname: James
authors.forename: P
authors.initials: P
authors.lastname: Janicki
authors.forename: P C
authors.initials: PC
authors.lastname: Uys
mesh_terms: D000328:Adult; D015760:Alfentanil / Q000627:therapeutic use*; D000773:Anesthesia, Obstetrical; D001034:Apgar Score; D001794:Blood Pressure / Q000187:drug effects*; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D011292:Premedication
chemical_list: D015760:Alfentanil; D008278:Magnesium Sulfate