Efficacy of various pretreatment and therapy regimens against soman lethality in mice.
The efficacy of a number of drug pretreatment combinations in protecting mice against lethal effects of soman was determined. Pyridostigmine peroral pretreatment followed by intramuscular postpoisoning therapy with atropine, obidoxime and/or trimedoxime, and diazepam protected mice against the lethal action of soman. Combination of pyridostigmine with trihexyphenidyl, benactyzine and bis-(4-hydroxyiminomethyl) pyridinium-methane dichloride improved prophylactic action even further.
Patocka
J
J
Purkynĕ Medical Academy, Hradec Králové.
Jakl
A
A
Bajgar
J
J
Fusek
J
J
D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D008297:Male; D051379:Mice; D009768:Obidoxime Chloride / Q000627:therapeutic use; D011041:Poisoning / Q000188:drug therapy / Q000517:prevention & control; D011729:Pyridostigmine Bromide / Q000627:therapeutic use; D012999:Soman / Q000633:toxicity*; D014282:Trihexyphenidyl / Q000627:therapeutic use; D014289:Trimedoxime / Q000627:therapeutic use
D009768:Obidoxime Chloride; D014289:Trimedoxime; D014282:Trihexyphenidyl; D001285:Atropine; D012999:Soman; D011729:Pyridostigmine Bromide; D003975:Diazepam