Antibodies to platelet-activating factor (PAF) inhibit PAF-induced platelet aggregation.
Platelet-activating factor (PAF) is the most potent platelet agonist known. PAF-induced platelet aggregation was blocked by pre-incubation of PAF with the immunoglobulin fraction from sheep or rabbit anti-PAF anti-serum. Inhibition was specific for PAF and was dependent upon immunoglobulin and PAF concentrations. Antibody-mediated inhibition of PAF-activity may be a valuable method for studying the biological effects of PAF in some systems.
Smal
M A
MA
Kolling Institute of Medical Research, Royal North Shore Hospital, St. Leonards, New South Wales, Australia.
Cooney
S J
SJ
Baldo
B A
BA
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D000001:Calcimycin / Q000494:pharmacology; D007136:Immunoglobulins / Q000008:administration & dosage; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D012756:Sheep; D013045:Species Specificity
D000906:Antibodies; D007136:Immunoglobulins; D010972:Platelet Activating Factor; D000001:Calcimycin; D000244:Adenosine Diphosphate