Mechanism of analgesic effect of clonidine in the treatment of dysmenorrhea.
Clonidine substantially reduces the pain and cramping of dysmenorrhea. The mechanisms for this effect may lie in increased release of analgesic opioids. It is suggested that perhaps a thromboxane synthetase inhibitor such as ginger which activates endorphin receptors may also be an effective treatment.
Backon
J
J
Mount Pleasant Hospital Addiction Studies Foundation, Lynn, MA.
D000700:Analgesics / Q000627:therapeutic use; D003000:Clonidine / Q000627:therapeutic use*; D004412:Dysmenorrhea / Q000188:drug therapy* / Q000503:physiopathology; D004723:Endorphins / Q000378:metabolism; D005260:Female; D006801:Humans; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors
D000700:Analgesics; D004723:Endorphins; D013930:Thromboxane-A Synthase; D003000:Clonidine