[Role of gastric mucosa prostaglandins in the development of ulcer lesions in liver cirrhosis].
The amount of prostaglandins (PD) E, F2 alpha and I2 (measured as 6-keto-Pg F1 alpha) in endoscopic biopsy specimens of gastric corpus' mucosa also as the concentration of Pg E and F2 in gastric juice of cirrhotic patients without or with gastric and duodenal ulcer were measured by radioimmunoassay. Release of Pgs with gastric juice (in the basal state and after histamine stimulation) was also significantly less in these patients. It was concluded that the severe disturbance of endogenous biosynthesis Pgs in gastroduodenal mucus of cirrhotic patients may play an important role in the development of ulcer disease in these patients.
Vysotskaia
R A
RA
Loginov
A S
AS
Kondashova
Z D
ZD
D001706:Biopsy; D002908:Chronic Disease; D015237:Dinoprost / Q000032:analysis; D004381:Duodenal Ulcer / Q000209:etiology; D005750:Gastric Juice / Q000737:chemistry; D005753:Gastric Mucosa / Q000737:chemistry*; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology*; D010437:Peptic Ulcer / Q000209:etiology*; D011453:Prostaglandins / Q000032:analysis*; D011458:Prostaglandins E / Q000032:analysis; D011863:Radioimmunoassay; D013276:Stomach Ulcer / Q000209:etiology
D011453:Prostaglandins; D011458:Prostaglandins E; D015237:Dinoprost
Rol' prostaglandinov slizistoĭ obolochki zheludka v razvitii iazvennykh porazheniĭ pri tsirroze pecheni.