Two cases of cicatricial pemphigoid showing atypical immunofluorescent findings.
We describe two patients with the clinical symptoms of cicatricial pemphigoid (CP). Biopsy specimens of the conjunctiva were taken. Histologic examination revealed subepidermal bullae and infiltration of inflammatory mononuclear cells. Direct immunofluorescent study showed immunoglobulins bound to the basement membrane zone (BMZ) in these patients. The patients also had intercellular immunoglobulin deposition in the conjunctival epithelium. No circulating anti-BMZ antibodies were detected, but one patient had a circulating antiintercellular antibody. Rare cases of CP with atypical immunofluorescent findings are reported.
Ishihara
M
M
Department of Ophthalmology, Yokohama City University, School of Medicine, Kanagawa, Japan.
Ishihara
H
H
Hatano
H
H
Ohno
S
S
D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D001485:Basement Membrane / Q000276:immunology; D003229:Conjunctival Diseases / Q000276:immunology* / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D010390:Pemphigoid, Benign Mucous Membrane / Q000276:immunology* / Q000473:pathology
D000974:Antibodies, Antinuclear; D007136:Immunoglobulins