title: Flecainide: evidence of non-linear kinetics.
abstract: The pharmacokinetics of flecainide has been studied in 12 patients with ventricular arrhythmias, both after single administration and during chronic treatment. Both the half-life and the AUC were significantly increased during chronic treatment. This suggests that the kinetics of flecainide might be non-linear also in patients with normal kidney and liver function. The increase in plasma flecainide levels during chronic treatment could not be predicted, so close monitoring of its plasma levels is advisable.
authors.affiliation: Institute of Cardiovascular Diseases, University of Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Boriani
authors.forename: E
authors.initials: E
authors.lastname: Strocchi
authors.forename: A
authors.initials: A
authors.lastname: Capucci
authors.forename: R
authors.initials: R
authors.lastname: Callivà
authors.forename: L
authors.initials: L
authors.lastname: Frabetti
authors.forename: E
authors.initials: E
authors.lastname: Ambrosioni
authors.forename: B
authors.initials: B
authors.lastname: Magnani
mesh_terms: D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D005424:Flecainide / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008875:Middle Aged
chemical_list: D005424:Flecainide