Orofacial pain sensitivity in adult rats following neonatal infraorbital nerve transection.
A modification of the formalin test was used to assess orofacial pain sensitivity in adult rats that received infraorbital nerve transection at birth. Normal and neonatally lesioned adult animals received an injection of either 5% formalin or saline vehicle into the whiskerpad and the duration of whiskerpad rubbing was observed for 45 min. Normal rats given formalin exhibited the previously reported biphasic pattern of rubbing. Neonatally lesioned rats given formalin did not exhibit this pattern, and were indistinguishable from either of the saline control groups.
Klein
B G
BG
Department of Biomedical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Misra
B R
BR
White
C F
CF
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D005145:Face / Q000294:innervation*; D009055:Mouth / Q000294:innervation*; D009416:Nerve Regeneration / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D009915:Orbit / Q000294:innervation*; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds / Q000502:physiology; D014276:Trigeminal Nerve / Q000502:physiology*; D014278:Trigeminal Nuclei / Q000502:physiology