title: Glycosylation of alpha 1-acid glycoprotein in relation to duration of disease in acute and chronic infection and inflammation.
abstract: Microheterogeneity of acute phase proteins frequently differs in acute and chronic types of inflammation. However, it is unknown whether these changes depend on the duration of the inflammation in a given disease. We therefore investigated the microheterogeneity of alpha 1-acid glycoprotein (AGP) in sera from patients with acute and chronic bacterial infection in comparison to rheumatoid arthritis and ankylosing spondylitis. In acute bacterial infection Con A-reactivity of AGP was significantly elevated. By contrast, AGP in chronic bacterial infection showed the same glycosylation pattern as rheumatoid arthritis and ankylosing spondylitis being characterized by a decreased reactivity to Con A. Serial measurements in individual patients with bacterial infections showed a transition from the initially elevated to decreased reactivity to Con A as the disease became chronic.
authors.affiliation: Department of Rheumatology, University Hospital, Felix-Platter-Spital, Basel, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Fassbender
authors.forename: W
authors.initials: W
authors.lastname: Zimmerli
authors.forename: R
authors.initials: R
authors.lastname: Kissling
authors.forename: M
authors.initials: M
authors.lastname: Sobieska
authors.forename: A
authors.initials: A
authors.lastname: Aeschlimann
authors.forename: M
authors.initials: M
authors.lastname: Kellner
authors.forename: W
authors.initials: W
authors.lastname: Müller
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000097:blood*; D001424:Bacterial Infections / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002908:Chronic Disease; D003208:Concanavalin A / Q000378:metabolism; D005260:Female; D006031:Glycosylation; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism*; D013167:Spondylitis, Ankylosing / Q000097:blood*; D013203:Staphylococcal Infections / Q000097:blood; D013290:Streptococcal Infections / Q000097:blood
chemical_list: D009961:Orosomucoid; D003208:Concanavalin A; D002097:C-Reactive Protein