Cardiovascular responses to tilting in healthy newborn babies.
It has been suggested that newborn infants have immature baroreceptor responses and they are unable to maintain their blood pressure (BP) by appropriate reflex peripheral vasoactivity and heart rate (HR) changes in response to tilting. We have measured simultaneously upper arm and calf systolic and diastolic BP and HR every 30 s using an oscillometric method (Dinamap 847) in quiet and active sleep in 9 term babies. Measurements were performed continuously with 5-min periods in each of three positions; horizontal, 30 degrees head up and 30 degrees head down tilt. The results were analysed using unbalanced analyses of variance and multivariate regression. All responses were proportional to the angle of the tilt. The observed values were very close to those predicted from the model. HR increased and decreased by 3.25 beats/min (bpm) on 30 degrees up and down tilting respectively and by twice this amount when tilting through 60 degrees. Arm systolic and diastolic BP both decreased by 1.3 mmHg when tilting through 60 degrees from down to up and increased correspondingly with down-tilting. Calf systolic BP changed appropriately for the change in hydrostatic pressure (+7.37 mmHg with 30 degrees up tilting), but diastolic BP rose only by 60% of this value. The results showed no individual variation, were independent of day, sleep state, the number of tilts, the starting value of the BP and the direction of the previous tilt. This study shows that the healthy newborn has a well developed baroreceptor reflex.
Thoresen
M
M
Department of Paediatrics, Ullevaal Hospital, Oslo, Norway.
Cowan
F
F
Walløe
L
L
D001794:Blood Pressure; D002320:Cardiovascular Physiological Phenomena; D003971:Diastole; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D011187:Posture; D011311:Pressoreceptors / Q000502:physiology; D012018:Reflex / Q000502:physiology; D013599:Systole