title: Effect of sho-saiko-to (TJ-9, Japanese herbal medicine) on estradiol receptors in the cytosol of hepatic sinusoidal endothelial cells.
abstract: We first confirmed the presence of estradiol receptors in the cytosol of rat hepatic sinusoidal endothelial cells and then studied the effects of Sho-saiko-to (TJ-9) on the level of these cytosol estradiol receptors. As a result, we found that estradiol receptors are present in the cytosol of hepatic sinusoidal endothelial cells from rats. Moreover, when these cells were incubated with TJ-9, the level of cytosol estradiol receptors increased. These results suggested that TJ-9 acts on hepatic sinusoidal endothelial cells to increase the level of estradiol receptors, thereby affecting the immune reactions in the liver.
authors.affiliation: Third Department of Internal Medicine, Osaka City University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizoguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Morisawa
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002478:Cells, Cultured; D003600:Cytosol / Q000737:chemistry* / Q000648:ultrastructure; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004727:Endothelium / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D007564:Japan; D008099:Liver / Q000166:cytology* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D011959:Receptors, Estradiol / Q000032:analysis* / Q000187:drug effects* / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D011959:Receptors, Estradiol; C018142:saiko-keishi-to