[Ca(2+)-dependent regulation of T-lymphocytes in experimental tuberculosis].
Ca(2+)-exchange kinetics and the content of membrane and cytoplasm fractions of calmodulin in the splenic T-lymphocytes of guinea pigs with experimental tuberculosis were studied. A tuberculous process was accompanied by the changes in the Ca2+ exchange kinetics in the form of T-lymphocyte oversaturation with Ca2+ ions which in the end leads to an inhibition of the functional status of the immunity T system. PPD, a specific allergen, brought the capacity of T lymphocytes down in relation to the cellular Ca2+ exchange, presumably causing the normalization of the immune response.
Demidov
S V
SV
Kostromin
A P
AP
Chernushenko
E F
EF
Kuibeda
V V
VV
Borovik
M I
MI
D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000502:physiology; D006168:Guinea Pigs; D013601:T-Lymphocytes / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000378:metabolism*
D002118:Calcium
Ca2+-zavisimaia reguliatsiia T-limfotsitov pri eksperimental'nom tuberculeze.