title: Predictors of side effects associated with lithium administration in children.
abstract: Data were pooled from three controlled and double-blind studies of lithium carbonate involving a total of 48 hospitalized children, and secondary data analyses were conducted. The objective was to assess whether there is a relationship between a child's chronological age and side effects associated with lithium administration. Two dependent measures of side effects were investigated: number of side effects per child and number of episodes of side effects per child. The children were diagnosed as having conduct disorder with a profile of severe aggressive and explosive behavior; their ages ranged from 5.08 to 12.92 yrs (mean, 9.23 yrs). For the entire sample of 48 children, the effect of age on side effects was statistically significant (p = .057); younger children had more side effects than older children. This relationship continued to hold after adjustment for weight, serum lithium levels, optimal dose, and duration of optimal dose.
authors.affiliation: Children's Inpatient Unit, Department of Psychiatry, Bellevue Hospital Center, New York, NY.
authors.forename: M
authors.initials: M
authors.lastname: Campbell
authors.forename: R R
authors.initials: RR
authors.lastname: Silva
authors.forename: V
authors.initials: V
authors.lastname: Kafantaris
authors.forename: J J
authors.initials: JJ
authors.lastname: Locascio
authors.forename: N M
authors.initials: NM
authors.lastname: Gonzalez
authors.forename: D
authors.initials: D
authors.lastname: Lee
authors.forename: N S
authors.initials: NS
authors.lastname: Lynch
mesh_terms: D002648:Child; D002653:Child Behavior Disorders / Q000188:drug therapy* / Q000523:psychology; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male
chemical_list: D008094:Lithium