title: Insulin resistance and blood pressure in Dahl rats and in one-kidney, one-clip hypertensive rats.
abstract: In normal rats, sucrose feeding results in insulin resistance and an elevation of arterial pressure. The purpose of this study was twofold: 1) to evaluate the effect of sucrose feeding on blood pressure in a genetic model and in an acquired model of hypertension and 2) to determine whether these models of hypertension are associated with insulin resistance. In Dahl salt-resistant (Dahl-R) rats on both a 0.45 and a 3% NaCl intake, systolic blood pressures were higher (P less than 0.01) in sucrose-drinking than in water-drinking animals. In contrast, blood pressure was not affected by dietary sucrose in Dahl salt-sensitive (Dahl-S) rats. Blood pressure was also not affected by sucrose in the one-kidney, one-clip (1K,1C) hypertensive rat. In response to an oral glucose load, serum glucose was similar in Dahl-R and Dahl-S rats, although serum insulin was higher (P less than 0.05) in Dahl-S rats, suggesting that Dahl-S rats are insulin resistant. In contrast, glucose and insulin responses were similar in hypertensive 1K,1C animals and normotensive controls. In conclusion, sucrose feeding increased blood pressure in Dahl-R but not in Dahl-S or 1K,1C hypertensive rats. Additionally, Dahl-S rats, but not hypertensive 1K,1C rats, are insulin resistant.
authors.affiliation: Department of Medicine, West Virginia University School of Medicine, Morgantown 26506.
authors.forename: T A
authors.initials: TA
authors.lastname: Kotchen
authors.forename: H Y
authors.initials: HY
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Covelli
authors.forename: N
authors.initials: N
authors.lastname: Blehschmidt
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004195:Disease Models, Animal; D005951:Glucose Tolerance Test; D006973:Hypertension / Q000503:physiopathology*; D007333:Insulin Resistance; D007668:Kidney / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D013395:Sucrose