The proteolytic activation of interleukin-1 beta.
Interleukin-1 beta (IL-1 beta) is released from an inactive precursor by a proteolytic cleavage. A monocytic protease has been identified that appears to be involved in the physiological activation of this cytokine. Two situations have been found in which precursor IL-1 beta exists without the monocytic processing enzyme, and in these cases other proteases, such as neutrophil elastase, cathepsin G and cathepsin L, may be involved in generating the active cytokine.
Black
R
R
Department of Protein Chemistry, Immunex Corp., Seattle, WA 98101.
Kronheim
S
S
Sleath
P
P
Greenstreet
T
T
Virca
G D
GD
March
C
C
Kupper
T
T
D002460:Cell Line; D010450:Endopeptidases / Q000502:physiology; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D009000:Monocytes / Q000201:enzymology
D007375:Interleukin-1; D010450:Endopeptidases