[Studies on pyridonecarboxylic acids as antibacterial agents. X. Synthesis and structure-activity relationships of 1, 7-disubstituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acids].
A series of pyridonecarboxylic acids were prepared. These compounds have different groups including substituted benzenes, furans and isoxazles at the 1-position, or different substituted amino groups at the 7-position. The in vitro antibacterial potencies of these compounds against E. coli. and S. aureus were tested, and structure-activity relationships were discussed.
Chen
J X
JX
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing.
Guo
H Y
HY
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D042462:4-Quinolones; D000890:Anti-Infective Agents