Introduction of Pneumocystis carinii in a colony of SCID mice.
Pneumocystis carinii-free SCID mice were housed closely exposed to corticosteroid-treated non-SCID mice in a conventional area of our laboratory animal facilities. A one-day exposure was sufficient for P. carinii transmission. The lung infection increased thereafter. Irradiation or splenectomy of SCID mice at the beginning of the exposure resulted in a marked increase of parasite multiplication. Extrapulmonary foci of pneumocystosis were detected in heart and spleen of SCID mice infected by P. carinii via air transmission.
Soulez
B
B
INSERM 42-369, Villeneuve d'Ascq, France.
Palluault
F
F
Cesbron
J Y
JY
Dei-Cas
E
E
Capron
A
A
Camus
D
D
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D016513:Mice, SCID; D011020:Pneumonia, Pneumocystis / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D015203:Reproducibility of Results; D013156:Splenectomy; D014916:Whole-Body Irradiation