Effect of stobadine on indomethacin- and ethanol-induced stomach lesions and gastric secretion.
Stobadine was found to inhibit the ulcerogenic activity of indomethacin in relation to the dose but was ineffective against the direct necrotizing action of ethanol. It also inhibited gastric acid secretion when administered intraduodenally. Although stobadine is considered to be a scavenger of free radicals, our results indicate that, under the given experimental conditions, it is rather the inhibition of gastric acid secretion that is responsible for its antiulcerogenic effect. The preliminary results do not allow the exclusion of other mechanisms for explaining its antiulcerogenic effect.
Mirossay
L
L
Department of Pharmacology, Faculty of Medicine, Safárik University, Kosice.
Kohút
A
A
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D000431:Ethanol; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects*; D007213:Indomethacin / Q000037:antagonists & inhibitors; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects* / Q000473:pathology
D000897:Anti-Ulcer Agents; D002243:Carbolines; D000431:Ethanol; D007213:Indomethacin; C100106:dicarbine