Macrolide-antifol synergism in anti-Pneumocystis carinii therapeutics.
The synergistic activities of anti-Pneumocystis drugs were investigated. Macrolide antibiotics alone and in combination with sulfonamides were tested for their effects on P. carinii pneumonia in rats.
Hughes
W T
WT
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003907:Dexamethasone; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D018942:Macrolides; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D013449:Sulfonamides / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D018942:Macrolides; D013449:Sulfonamides; D003907:Dexamethasone