[The effect of anabolic steroids on proliferative activity of thymocytes].
Testosterone, methandrostenolone during ten-day injections to mice 50 mg/kg decrease mass, quality of DNA and 3H thymidine in Thymus. In vitro these drugs loss 3H-thymidine incorporation at 10(-5) M. Ecdysthene do not influence proliferative activity of thymocytes in vitro and thymolytyc effect in vivo. The present results indicate, that proliferative process may have a functional significance in thymolytycal effects of anabolic steroids.
Sergeev
P V
PV
Semeĭkin
A V
AV
Dukhanin
A S
AS
Solov'eva
E V
EV
D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D004247:DNA / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D004441:Ecdysterone / Q000494:pharmacology; D008696:Methandrostenolone / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size; D013739:Testosterone / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*
D045930:Anabolic Agents; D013739:Testosterone; D004441:Ecdysterone; D003907:Dexamethasone; D004247:DNA; D008696:Methandrostenolone; D013936:Thymidine
Vliianie anabolicheskikh steroidov na proliferativnuiu aktivnost' timotsitov]