title: Rheumatoid arthritis antirheumatic drug trials. I. Effects of standardization procedures on observer dependent outcome measures.
abstract: A study was designed to assess the effects of standardization procedures on reducing interobserver variability for outcome measures given in the current Food and Drug Administration and European League Against Rheumatism guidelines and others selected from the rheumatology literature. Over 2 days, 6 rheumatologists independently examined 6 patients with rheumatoid arthritis (RA) in predetermined order before and after standardizing their examination techniques. An important and beneficial effect of the standardization procedure was observed on the majority of outcome variables. Such reductions in observer variability have the potential to diminish sample size requirements for antirheumatic drug studies.
authors.affiliation: Division of Rheumatology, University of Western Ontario, London, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Bellamy
authors.forename: T P
authors.initials: TP
authors.lastname: Anastassiades
authors.forename: W W
authors.initials: WW
authors.lastname: Buchanan
authors.forename: P
authors.initials: P
authors.lastname: Davis
authors.forename: P
authors.initials: P
authors.lastname: Lee
authors.forename: G A
authors.initials: GA
authors.lastname: McCain
authors.forename: G A
authors.initials: GA
authors.lastname: Wells
authors.forename: J
authors.initials: J
authors.lastname: Campbell
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008875:Middle Aged; D015588:Observer Variation; D017063:Outcome Assessment, Health Care; D012107:Research Design
chemical_list: D000893:Anti-Inflammatory Agents