Effect of ambrein on blood glucose levels of rats.
Ambrein reduced the blood glucose level of normal and moderately alloxan-diabetic rats but did not reduce the blood glucose levels of severely-diabetic rats. Ambrein did not reduce the hyperglycemia of glucose-loaded rats also given mannoheptulose but it reduced the hyperglycemia of glucose-loaded rats in the absence of mannoheptulose. Results suggested that the hypoglycemic activity of ambrein may be mediated by enhanced glucose utilization.
Taha
S A
SA
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D009284:Naphthols / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012720:Severity of Illness Index; D014315:Triterpenes
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009284:Naphthols; D014315:Triterpenes; C074170:ambrein