[Hemodynamic factors forming glycoside resistance in patients with mitral valve defects complicated by congestive heart failure].
Overall 75 patients with rheumatic mitral heart disease were examined for the effect of the clinical and echocardiography characteristics of central and intracardiac hemodynamics on the efficacy of the use of digoxin. The development of digoxin resistance in patients with the predominance of stenosis of the mitral opening depended to the greatest degree on the duration of heart decompensation, area of the mitral opening and duration of the phase of left ventricle relaxation; in patients with the predominance of mitral insufficiency, it depended on the level of endosystolic stress, pressure of left ventricle filling and duration of the phase of isometric left ventricle contraction. Based on the calculation of the information content of the parameters under study, a prognostic table was made. The use of the table allowed forecasting the development of glycoside resistance in 77.6% of cases.
Dormidontov
E N
EN
Khrustalev
O A
OA
D000328:Adult; D002301:Cardiac Glycosides / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D004077:Digoxin / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D004351:Drug Resistance; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D008946:Mitral Valve Stenosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D011379:Prognosis; D012214:Rheumatic Heart Disease / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology
D002301:Cardiac Glycosides; D004077:Digoxin
Gemodinamicheskie faktory formirovaniia glikozidorezistentnosti u bol'nykh mitral'nymi porokami serdtsa, oslozhnennymi zastoĭnoĭ serdechnoĭ nedoststaochnost'iu.