title: [Immunomodulating peptides, regulation of interleukin-2 expression and its possible mechanism].
abstract: The influence of some immunomodulation peptides SKD, R and L on the interleukin-2 (IL-2) synthesis in T-lymphocytes and possibility of their specific interaction with nucleotide sequences of IL-2 gene were studied. It was firstly shown that peptides R and L specifically interacted with regulatory nucleotide sequences of IL-2 gene and, possibly, play a key role in the immunomodulation actions on the IL-2 production.
authors.forename: T B
authors.initials: TB
authors.lastname: Kazakova
authors.forename: A A
authors.initials: AA
authors.lastname: Miul'berg
authors.forename: S V
authors.initials: SV
authors.lastname: Burov
authors.forename: O I
authors.initials: OI
authors.lastname: Golovko
authors.forename: T V
authors.initials: TV
authors.lastname: Grishina
authors.forename: V M
authors.initials: VM
authors.lastname: Morozov
authors.forename: L Ch
authors.initials: LCh
authors.lastname: Neustroeva
authors.forename: G V
authors.initials: GV
authors.lastname: Gushchin
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D007376:Interleukin-2 / Q000096:biosynthesis / Q000235:genetics*; D051379:Mice; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism
chemical_list: D000276:Adjuvants, Immunologic; D007376:Interleukin-2
vernacular_title: Immunomoduliruiushchie peptidy, reguliatsiia obrazovaniia interleĭkina-2 i vozmozhnyĭ ee mekhanizm.