title: Differentiation of endothelial cells in avian embryos does not depend on gastrulation.
abstract: Unincubated quail eggs were treated with Cytochalasin B. By this means, gastrulation of the blastodiscs was inhibited. Fragments of these blastodiscs were grafted into wings buds of chick embryos, and the differentiation fate of graft-derived cells was studied. Results show that only endothelial cells differentiate from the grafts. They were even found outside the graft site in vessels made up of a chimeric endothelium. It can be concluded that determination, differentiation and migration of endothelial cells does not depend on gastrulation.
authors.affiliation: Anatomisches Institut, Albert-Ludwigs-Universität Freiburg.
authors.forename: B
authors.initials: B
authors.lastname: Christ
authors.forename: M
authors.initials: M
authors.lastname: Grim
authors.forename: J
authors.initials: J
authors.lastname: Wilting
authors.forename: K
authors.initials: K
authors.lastname: von Kirschhofer
authors.forename: F
authors.initials: F
authors.lastname: Wachtler
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003370:Coturnix; D003571:Cytochalasin B / Q000494:pharmacology; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000196:embryology*; D005775:Gastrula / Q000166:cytology / Q000502:physiology*
chemical_list: D003571:Cytochalasin B