GAX-collagen in the human vocal fold.
A report is presented of the first histological study of GAX-collagen injected into the human vocal cord. The study concerns a specimen from an arytenoidectomy performed 28 months after injection. As it had already been the case in the animal, the excellent integration of GAX-collagen with the host-tissues has been noted, as well as the stability of the result more than 2 years later. It also appeared that colonization of GAX-collagen by the host cells is less rapid than for the ZCI. While inflammatory reaction is weak in the region of the GAX-collagen, there is to be seen some atrophy and fibrosis of the muscular fibres around the deposit, probably due to compression during injection.
Marbaix
E
E
Department of Pathology, University Hospital St.-Luc, Brussel, Belgium.
Remacle
M
M
D003094:Collagen / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008875:Middle Aged; D014826:Vocal Cord Paralysis / Q000628:therapy*; D014827:Vocal Cords / Q000473:pathology*
C075314:GAX-collagen; D003094:Collagen