[Identification of serotonin-modulated protein fraction and study of its role in passive avoidance reaction in rats].
The effect 10(-3) M serotonin and norepinephrine solutions application on the brain occipital cortex on discrete water soluble protein fractions content was investigated in narcotized rats. It was revealed that application of serotonin solution caused repeated decrease in N6 fraction content. Immunoglobulins against N6 fraction being injected into the lateral ventricle of rat brain increased the number of photocell crossing and the presence probability of rats at the dark compartment entrance region in passive avoidance schedule. The conclusion of selective serotonin participation in regulation of brain cortex discrete proteins turnover and of these proteins involvement in searching behavior was made.
Gasanov
G G
GG
Mekhtiev
A A
AA
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D004589:Electrophoresis, Disc; D004797:Enzyme-Linked Immunosorbent Assay; D004924:Escape Reaction; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D009419:Nerve Tissue Proteins; D012701:Serotonin; D009638:Norepinephrine
Vyiavlenie serotonin-moduliruemoĭ belkovoĭ fraktsii i izuchenie ee uchastiia v organizatsii povedeniia passivnogo izbeganiia u krys.