Studies on mitochondrial metabolic processes in offspring of alcoholized rats--I. Evidence for altered activity and sensitivity to monoamine oxidase-dependent control by biogenic amines of some membrane-bound enzymes.
In the liver mitochondrial fraction of the first generation offspring of alcoholized male rats, decreased activities of monoamine oxidase (MAO) types A and B, rotenone-insensitive NADH-cytochrome c-reductase and succinate dehydrogenase were observed. The MAO-dependent inhibition of rotenone-insensitive NADH-cytochrome c-reductase and succinate dehydrogenase by biogenic amines, incubated with the mitochondrial fraction, was altered in the offspring of alcoholized animals as compared with control rats. The sensitivity of these enzymatic activities towards the inhibitory effect of 5-methoxyindol-3-ylacetaldehyde was markedly increased in the offspring of alcoholized male rats. The data obtained suggest the existence of a genetically determined predisposition of the mitochondrial metabolic processes in the offspring of the alcoholized rats to the effects of ethanol and to the toxic effects of acetaldehyde, formed during ethanol metabolism.
Anokhina
I P
IP
All-Union Research Centre for Medico-Biological Problems of Narcology, Ministry of Public Health, Moscow, U.S.S.R.
Gorkin
V Z
VZ
Medvedev
A E
AE
Ovchinnikova
L N
LN
Khristolyubova
N A
NA
D000437:Alcoholism / Q000201:enzymology / Q000235:genetics*; D000818:Animals; D001679:Biogenic Amines / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000502:physiology*; D009245:NADH Dehydrogenase / Q000378:metabolism*; D051381:Rats; D012402:Rotenone / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D001679:Biogenic Amines; D012402:Rotenone; D013385:Succinate Dehydrogenase; D008995:Monoamine Oxidase; D009245:NADH Dehydrogenase