[The role of the endothelium in the development of functional hyperemia of the skeletal muscles].
Experiments on anesthesized dogs demonstrated that gastrocnemius muscle vessels working hyperemia substantially decreased after chemical destruction of endothelium by saponin, inhibition of endothelium-derived relaxing factor synthesis by gossypol and inhibition of quanylate cyclase by methylene blue. Reaction was not decreased after cyclooxygenase inhibition by indomethacin. The endothelium-derived relaxing factor predecessor--L-arginine essentially increased working hyperemia. We concluded that endothelium plays an important role in reaction of working hyperemia by endothelium-derived relaxing factor release.
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D000818:Animals; D001120:Arginine / Q000494:pharmacology; D004285:Dogs; D004558:Electric Stimulation; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D006072:Gossypol / Q000494:pharmacology; D006614:Hindlimb / Q000098:blood supply / Q000187:drug effects; D006940:Hyperemia / Q000209:etiology* / Q000503:physiopathology; D007213:Indomethacin / Q000494:pharmacology; D007537:Isometric Contraction / Q000187:drug effects / Q000502:physiology; D008751:Methylene Blue / Q000494:pharmacology; D009132:Muscles / Q000098:blood supply* / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012503:Saponins / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D012503:Saponins; D001120:Arginine; D006072:Gossypol; D008751:Methylene Blue; D007213:Indomethacin
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