[Regulation of Ca(2+)-dsRNA for proliferation and terminal differentiation processes of human fibroblasts and HeLa cells].
Ca2+ complexes of dsRNA, poly(dA) and poly(dT) of yeast low molecular weight RNA produce a pronounced mitogenic effect on human fibroblasts at early stages of fibroblast proliferation in culture. At later stages of cell cultivation Ca(2+)-dsRNA stimulates terminal differentiation by inducing the synthesis of proteins characteristic of the postmitotic population of human fibroblasts undergoing terminal differentiation. Ca(2+)-dsRNA produces a stimulating effect on c-fos and c-jun gene transcription in fibroblasts and HeLa-S-3.
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D002118:Calcium / Q000378:metabolism*; D002413:Cations, Divalent; D002454:Cell Differentiation; D002455:Cell Division; D004247:DNA / Q000378:metabolism; D015180:Electrophoresis, Gel, Two-Dimensional; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D016762:Genes, fos; D016758:Genes, jun; D016259:Genes, myc; D006367:HeLa Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D012330:RNA, Double-Stranded / Q000378:metabolism*; D012331:RNA, Fungal / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism; D014158:Transcription, Genetic
D002413:Cations, Divalent; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D004247:DNA; D002118:Calcium; D013936:Thymidine
Reguliatsiia (Ca2+)-dsRNK protsessov proliferatsii i terminal'noĭ differentsiovki fibroblastov cheloveka, kletok HeLa.