Acute parkinsonian syndrome with demyelinating leukoencephalopathy in bone marrow transplant recipients.
A syndrome of rigidity, bradykinesia, spasticity, and often myoclonus and dementia developed acutely in 5 patients who had undergone successful engraftment of bone marrow transplants for the treatment of various hematologic diseases. Magnetic resonance imaging demonstrated widespread changes in white matter; brain biopsy disclosed mild demyelination associated with active phagocytosis of myelin. One patient, who was not treated, remains severely demented. Patients treated with very high-dose methylprednisolone had complete clinical recovery.
Lockman
L A
LA
Division of Pediatric, University of Minnesota Medical School, Minneapolis.
Sung
J H
JH
Krivit
W
W
D000293:Adolescent; D000741:Anemia, Aplastic / Q000150:complications / Q000601:surgery / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D016465:Bone Marrow Purging; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D003131:Combined Modality Therapy; D003704:Dementia / Q000209:etiology*; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005260:Female; D005911:Gliosis / Q000134:cerebrospinal fluid / Q000209:etiology / Q000473:pathology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007938:Leukemia / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D010302:Parkinson Disease, Secondary / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D016756:Immunoglobulins, Intravenous; D008775:Methylprednisolone