[Transdermal nitroglycerin in stable effort angina. II. Administration of continuous high doses and alternate high-low doses. Absence of tolerance].
Aim of this study was to evaluate the efficacy of 2 different schedules of nitroglycerin (N), given by means of transdermal therapeutic system (TTS): continuous (20 mg patch at 8.00 am and at 8.00 pm NTTS/c) and high/low doses therapy (20 mg patch at 8.00 am and 10 mg at 8.00 pm NTTS/a), respectively. Eighteen volunteers, gave informed, written consent; male patients, aged 57 +/- 2 years, with stable effort angina pectoris, were randomly given, in double-blind condition, NTTS/c, NTTS/a or placebo (PL), each for 1 week period, according to a 3 x 3 latin square design. Bicycle exercise tests were performed on the first and on the last day of each period of the study, 12 hours after the last patch. NTTS/c and NTTS/a increased ischemic threshold and decreased the ischemic depression ST at maximal common work, compared to placebo, without differences between tests performed at 1 and 7 day. In conclusion, NTTS/a showed antiischemic activity after 7 days, so no tolerance was observed in those patients.
Lai
C
C
Istituto di Cardiologia, Università degli Studi, Cagliari.
Alberti
D
D
Onnis
E
E
Orani
E
E
Soro
A
A
Pirisi
R
R
Lai
G
G
Cadeddu
M
M
D000279:Administration, Cutaneous; D000787:Angina Pectoris / Q000188:drug therapy*; D001794:Blood Pressure; D004311:Double-Blind Method; D004361:Drug Tolerance; D005080:Exercise Test; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage*; D013997:Time Factors
D005996:Nitroglycerin
La nitroglicerina transdermica nell'angina pectoris da sforzo stabile: II--Somministrazione a dosi alte continue e dosi alte-basse alternate. Assenza di tolleranza.