Enantioselective behavioral effects of threo-methylphenidate in rats.
The relative potency of d- and l-threo-methylphenidate (d-MPH and l-MPH) was evaluated using three behavioral paradigms for rats: Responding maintained by a fixed-interval schedule of reinforcement (FI), responding maintained by a concurrent variable-interval schedule of reinforcement (Conc VI VI), and consumption of sweetened condensed milk during a 15-min free-access period. In each case the potency of the d-MPH enantiomer greatly exceeded that of the l-MPH enantiomer. Temporal control of responding was reduced (FI) choice responding was equalized for most rats (Conc VI VI), and milk consumption was suppressed by d-MPH and dl-MPH.
Eckerman
D A
DA
Department of Psychology, University of North Carolina, Chapel Hill 27599.
Moy
S S
SS
Perkins
A N
AN
Patrick
K S
KS
Breese
G R
GR
D000818:Animals; D000855:Anorexia / Q000139:chemically induced; D001066:Appetite / Q000187:drug effects; D001067:Appetite Depressants / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D008774:Methylphenidate / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D012055:Reinforcement Schedule; D013237:Stereoisomerism
D001067:Appetite Depressants; D008774:Methylphenidate