title: Immobilization of yeast and the function of immobilized yeast.
abstract: Hansenula anomala, which catalyzes an asymmetric reduction, was immobilized in bulk or spherical crosslinked polymers. The catalytic activity of the yeast for enantio-selective reduction of 3,8-dioxo-4-methoxycarbonyl-9-methyl-delta 4(10)-octalin (lab) was severely affected by the immobilization conditions, such as the crosslink density, and by hydrophobicity of polymers and other components used for immobilization, oxygen concentration in the medium, etc. In some immobilized systems, the ratio of resulting enantiomers was inverted from that in a free yeast system.
authors.affiliation: Department of Applied Chemistry, Faculty of Science & Technology, Keio University, Yokohama, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuka
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Inayama
mesh_terms: D003432:Cross-Linking Reagents; D010084:Oxidation-Reduction; D010843:Pichia / Q000378:metabolism*; D011108:Polymers
chemical_list: D003432:Cross-Linking Reagents; D011108:Polymers