title: Left ventricular function changes during pharmacological and physiological interventions and routine activities monitored in healthy volunteers by a portable radionuclide probe (VEST).
abstract: A miniaturized radionuclide cardiac probe incorporated in a semi-rigid plastic chest garment has made ambulatory left ventricular (LV) function evaluation possible, with gated nuclear data being stored on tape together with electrocardiographic data, for subsequent off-line processing. After red blood cell labelling with 555 MBq (15 mCi) 99mTc and standard gated blood pool imaging in 45 degrees LAO, we performed a continuous monitoring of LV function in 20 healthy male volunteers (age range: 22-25 years), in resting control conditions as well as during activities (standing, walking, climbing stairs) and after interventions (isosorbide dinitrate intake, Trendelenburg position, inflation of cuffs around the thighs). VEST-monitoring proved to be a reliable method that gave reproducible results: changes of ejection (EF) in basal conditions were lower than 5% in 95% of the patients. Changes in LV function caused by daily activities were easily demonstrated. While standing effected no significant EF changes, walking and climbing increased EF by 6.9% (p less than 0.05) and 21.2% (p less than 0.05) respectively. Changes in LV volumes caused by alterations in venous return were also demonstrated. Compared with baseline, Trendelenburg increased end-diastolic volume (EDV) by 2.9% while isosorbide dinitrate and inflation of cuffs decreased it by 5.7% and 2.2% respectively.
authors.affiliation: Department of Nuclear Medicine, University Hospital, U.Z. Gasthuisberg, Leuven, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Mortelmans
authors.forename: E Z
authors.initials: EZ
authors.lastname: Cabrera
authors.forename: N
authors.initials: N
authors.lastname: Dorny
authors.forename: J
authors.initials: J
authors.lastname: Thoeng
authors.forename: M
authors.initials: M
authors.lastname: Wauters
authors.forename: F
authors.initials: F
authors.lastname: van de Werf
authors.forename: J
authors.initials: J
authors.lastname: VanHaecke
authors.forename: M
authors.initials: M
authors.lastname: de Roo
authors.forename: H
authors.initials: H
authors.lastname: de Geest
mesh_terms: D000328:Adult; D015716:Electrocardiography, Ambulatory; D015444:Exercise; D015637:Gated Blood-Pool Imaging; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*; D012815:Signal Processing, Computer-Assisted; D013318:Stroke Volume; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology
chemical_list: D007548:Isosorbide Dinitrate