Plasma kinetics of tritiated d-alpha-tocopherol in sheep given intravenously in emulsion or ethanol.
Thirteen crossbred wethers were given intravenously tritiated d-alpha-tocopherol (2 microCi/kg of bw) dissolved in emulsion or ethanol. Kinetic evaluation of the plasma specific activity versus time data was performed using either the 2- or 3-compartment model. The disappearance of the radiolabelled alpha-tocopherol from the plasma pool was affected by the nature of the vehicle administered. Radiotocopherol was cleared from plasma much faster when it was dissolved in ethanol than in emulsion; when radiotocopherol was injected as an emulsion concentration time curves were best described as a 2-compartment open model and in ethanol the kinetic data fitted a sum of three exponentials. The data showed higher bioavailability of the intravenously injected vitamin E in emulsion over ethanol.
Hidiroglou
M
M
Agriculture Canada, Animal Research Centre, Ottawa, Ontario.
D000818:Animals; D001682:Biological Availability; D003198:Computer Simulation; D004655:Emulsions; D000431:Ethanol; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D008954:Models, Biological; D012756:Sheep / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D004655:Emulsions; D014810:Vitamin E; D000431:Ethanol