title: Appearance and localization of dystrophin in normal human fetal muscle.
abstract: We studied the localization of dystrophin in normal human fetal muscle by immunohistochemistry. Our results show the appearance of dystrophin at week 11 and a progressive organization of the protein along membrane in the following weeks of gestation. At week 22 almost all fibers show a clear membrane immunostaining. Concomitant analysis of muscle fiber-type composition reveals no correlation between progressive appearance of dystrophin and muscle fiber-type differentiation. Our findings suggest that synthesis and localization of dystrophin in developing human skeletal muscle is time-related and probably independent of neuronal influences.
authors.affiliation: Centro Dino Ferrari, Università di Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Prelle
authors.forename: L
authors.initials: L
authors.lastname: Chianese
authors.forename: M
authors.initials: M
authors.lastname: Moggio
authors.forename: A
authors.initials: A
authors.lastname: Gallanti
authors.forename: M
authors.initials: M
authors.lastname: Sciacco
authors.forename: N
authors.initials: N
authors.lastname: Checcarelli
authors.forename: G
authors.initials: G
authors.lastname: Comi
authors.forename: E
authors.initials: E
authors.lastname: Scarpini
authors.forename: E
authors.initials: E
authors.lastname: Bonilla
authors.forename: G
authors.initials: G
authors.lastname: Scarlato
mesh_terms: D016189:Dystrophin / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D007536:Isomerism; D009132:Muscles / Q000033:anatomy & histology / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism; D011247:Pregnancy
chemical_list: D016189:Dystrophin; D009218:Myosins