Autoimmune haemolytic anaemia due to anti-phospholipid antibodies.
The clinical course and laboratory findings of a patient with autoimmune haemolytic anaemia due to anti-phospholipid antibodies and secondary to a systemic lupus erythematosus-like syndrome are described. IgG and IgM with anti-phospholipid activity coexisted in both sera and acid eluates prepared from the patient's red cells, as demonstrated by ELISA using a panel of anionic and neutral phospholipids. The anti-erythrocyte binding activity of eluted autoantibodies, determined by a radioactive antiglobulin technique, was totally inhibited by absorption with phospholipid micelles. The patient's serum also contained an IgM warm haemolysin detectable with enzyme-treated cells only, as well as anti-C, -E and -S alloantibodies.
Arvieux
J
J
Laboratoire d'Immunologie, Centre Hospitalier Universitaire, Grenoble, France.
Schweizer
B
B
Roussel
B
B
Colomb
M G
MG
D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000097:blood*; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010743:Phospholipids / Q000276:immunology*
D001323:Autoantibodies; D010743:Phospholipids