Magnetic resonance (MR) evaluation of bone marrow in vertebral bodies.
Magnetic Resonance (MR) imaging was used to examine the hematopoietic bone marrow in the vertebral bodies of eight healthy subjects, and of 35 cancer patients who had been previously treated with radiation therapy. MR was instrumental in distinguishing viable hematopoietic tissue (red marrow) from adipose tissue (yellow marrow), whose presence reflected the extent of radiation-induced bone marrow injury. Different water content in proliferating hematopoietic tissue and adipose tissue enabled clear distinction of the two components even inside the same vertebral body. Three patterns of bone marrow viability were observed in irradiated patients: 1. Patients undergoing therapy at the time of MR study, and patients who had received low-intermediate dose several years before MR examination showed no alteration as compared with healthy controls (i.e. homogeneous presence of red marrow). 2. Patients who had received low-intermediate dose few years before MR, showed either partial re-colonization of yellow marrow or almost complete ablation of active red marrow with rare areas of re-colonization. 3. Patients who had received high dose, showed complete depletion of red marrow (fatty substitution) independently of the length of time elapsed since radiation therapy. Therefore, bone marrow recovery after radiation therapy was associate with two variables: received dose and length of time allowed for re-colonization by surviving hematopoietic tissue. In conclusion, our results provide evidence that MR can be purposively used to study composition and distribution of normal bone marrow, and to asses the extent of radiation-induced bone marrow injury; to monitor bone marrow recovery (or the lack of it); and in the general follow-up of treated cancer patients.
Orlandini
G E
GE
Department of Human Anatomy and Histology, University of Sassari, Italy.
Ruggiero
L
L
Gulisano
M
M
Ruggiero
M
M
Villari
N
N
Casamassima
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000033:anatomy & histology* / Q000528:radiation effects; D001855:Bone Marrow Diseases / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology*; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D013122:Spinal Diseases / Q000209:etiology / Q000473:pathology*; D013131:Spine / Q000033:anatomy & histology* / Q000528:radiation effects; D013997:Time Factors