The dynamics of distribution and excretion of butyl-(2,3-14C)-acrylate in male Wistar albino rats.
The disposition of butyl-(2,3-14C)-acrylate has been studied following intraperitoneal and oral administration to rats. Most of the administrated acrylate underwent rapid metabolism and excretion with expired air (more than 70% of the dose) and urine (15-22%). Most of 14C found in tissues was associated with the liver and kidneys. The level of 14C associated with most of the examined tissues remained unchanged, at least, for the first 8-10 hours, followed by its fairly rapid loss. The only exception was erythrocytes, fat and the sciatic nerve. Significant differences in the rate of 14C loss from tissues were found in relation to the route of its administration.
Sapota
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Department of Metabolism of Toxic Substances, Institute of Occupational Medicine, Lodz, Poland.
D000179:Acrylates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000395:Air Pollutants, Occupational / Q000493:pharmacokinetics; D000818:Animals; D002250:Carbon Radioisotopes; D007263:Infusions, Parenteral; D007441:Intubation, Gastrointestinal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
D000179:Acrylates; D000395:Air Pollutants, Occupational; D002250:Carbon Radioisotopes; C032490:n-butyl acrylate