Warthin's tumor as a hamartomatous dysplastic lesion: a histochemical and immunohistochemical study.
The etiology of Warthin's tumor was sought by histochemical and immunohistochemical methods using 7 surgically extirpated samples and normal salivary glands as a control for the epithelial component. All the samples exhibited a variety of amyloid deposition in the interfollicular area of the lymphoid component. The interfollicular lymphoid cells were both T-cells and cells of B-cell lineage with an almost 1 to 2 population ratio. Most antigen-positive B-cells were plasma cells that exhibited polyclonality of immunoglobulin. B-cells were also present in the lymphoid mantles and a few were found in the germinal centres. The epithelial component exhibited mucinous and proteinaceous fluid in the lumen and varied immunohistological reactions; being particularly positive to carcinoembryonic antigen, S-100 protein, and B-cell antigen; quite similar to that of normal salivary duct cells. The results suggest that Warthin's tumor may not be a hamartomatous neoplasm at all but a hamartomatous dysplastic lesion.
Ohmori
T
T
Second Department of Pathology, Ehime University School of Medicine, Japan.
Uraga
N
N
Tabei
R
R
D000235:Adenolymphoma / Q000737:chemistry / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000737:chemistry*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D006222:Hamartoma / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology*; D013601:T-Lymphocytes / Q000737:chemistry*
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D009418:S100 Proteins