[The blast transformation capacity and karyotypic characteristics of the T-lymphocytes in hemolytic disease of the newborn].
The blood of 6 newborn boys with haemolytic disease of newborns and of 3 healthy newborn boys was examined. In all 949 metaphase plates were analysed. In all the investigated plates the karyotype was masculine, 46,XY [correction of 46HY]. The mitotic index is lowered considerably in sick children that suggests inhibition of their cellular immunity. In these conditions, the K and L lymphocytes of donor blood, introduced in substituting blood transfusion, can interact with the sensitized erythrocytes in accordance with the type of reaction "the transplant against the host" causing the increase in the level of bilirubin after the operation. It is expedient to study the possibility of realization of substituting blood transfusion using the leucocyte-free blood.
Ovchinnikova
L V
LV
Shtil'bans
V I
VI
Shandlorenko
S K
SK
D002478:Cells, Cultured / Q000276:immunology / Q000648:ultrastructure; D004899:Erythroblastosis, Fetal / Q000097:blood / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008213:Lymphocyte Activation; D008297:Male; D008940:Mitotic Index; D013601:T-Lymphocytes / Q000276:immunology* / Q000648:ultrastructure
Sposobnost' k blasttransformatsii i kariotipicheskaia kharakteristika T-limfotsitov pri gemoliticheskoĭ bolezni novorozhdennykh.