Human umbilical cord as a possible source of progesterone.
Homogenates of human term umbilical cord were incubated with 7n-3H-pregnenolone. Using a reverse-isotope dilution technique, 3H-progesterone was isolated and characterized. The extent of enzymic conversion ranged from 2.5 to 55.4%. The results indicate that the cord can be a source of progesterone during human pregnancy.
Gunasegaram
R
R
Institute of Science and Forensic Medicine, National Blood Centre, Singapore.
Peh
K L
KL
Loganath
A
A
Chew
P C
PC
Ratnam
S S
SS
D000328:Adult; D003460:Crystallization; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011284:Pregnenolone / Q000737:chemistry / Q000502:physiology; D011374:Progesterone / Q000096:biosynthesis* / Q000502:physiology; D014470:Umbilical Cord / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology
D011374:Progesterone; D011284:Pregnenolone