[Bases of the antibacterial effect of beta lactam antibiotics].
The primary antibacterial effect of betalactam antibiotics is due to the inhibition of cell-wall synthesis. Prerequisites for good antibacterial activity of such an antibiotic are --rapid penetration across the bacterial cell wall, --strong binding to the proper targets in the cytoplasmic membrane, i.e. the penicillin-binding proteins, --resistance to betalactamases which may be produced by the bacterial cell.
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Institut für Medizinische Mikrobiologie und Hygiene, Klinikum der Stadt Mannheim, Fakultät für Klinische Medizin Mannheim, Universität Heidelberg.
D000900:Anti-Bacterial Agents / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects*; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000378:metabolism; D004352:Drug Resistance, Microbial; D006602:Hexosyltransferases; D015394:Molecular Structure; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D047090:beta-Lactams; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase
Grundlagen der antibakteriellen Wirkung von Betalaktamantibiotika.