Effect of cisplatin on lipid peroxidation in blood platelets.
Cisplatin (cis-diamminedichloroplatinum II) at the concentrations of 2-20 micrograms induces non-enzymatic peroxidation of pig platelet lipids. At low concentration (0.1 microgram) it inhibits the enzymatic thrombin-stimulated transformation of platelet endogenous arachidonic acid. This drug also reduces the activities of platelet enzymes: superoxide dismutase and glutathione peroxidase.
Wachowicz
B
B
Department of Biochemistry, University of Lódź, Poland.
D000818:Animals; D001095:Arachidonic Acids / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D002945:Cisplatin / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000097:blood; D013552:Swine; D013917:Thrombin / Q000494:pharmacology
D001095:Arachidonic Acids; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D013917:Thrombin; D002945:Cisplatin