Epidemiological and experimental aspects of metal carcinogenesis: physicochemical properties, kinetics, and the active species.
The carcinogenic properties of selected metals and their compounds are reviewed to provide a useful reference for existing knowledge on relationships between physical and chemical forms, kinetics and carcinogenic potential and between epidemiology, bioassays, and short-term tests. Extensive consideration is given to arsenic, beryllium, cadmium, chromium, lead, and nickel. Other metals such as antimony, cobalt, copper, iron, manganese, selenium, and zinc are discussed briefly.
Magos
L
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MRC Toxicology Unit, Carshalton, Surrey, UK.
D000818:Animals; D001151:Arsenic / Q000009:adverse effects / Q000493:pharmacokinetics; D001608:Beryllium / Q000009:adverse effects / Q000493:pharmacokinetics; D002104:Cadmium / Q000009:adverse effects / Q000493:pharmacokinetics; D002857:Chromium / Q000009:adverse effects / Q000493:pharmacokinetics; D006224:Cricetinae; D003412:Cricetulus; D004285:Dogs; D004812:Epidemiologic Methods; D006168:Guinea Pigs; D006801:Humans; D007854:Lead / Q000009:adverse effects / Q000493:pharmacokinetics; D008253:Macaca mulatta; D008297:Male; D008647:Mesocricetus; D008670:Metals / Q000009:adverse effects / Q000493:pharmacokinetics*; D051379:Mice; D009152:Mutagenicity Tests; D009369:Neoplasms / Q000139:chemically induced*; D009532:Nickel / Q000009:adverse effects / Q000493:pharmacokinetics; D011817:Rabbits; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains
D008670:Metals; D002104:Cadmium; D002857:Chromium; D007854:Lead; D009532:Nickel; D001151:Arsenic; D001608:Beryllium