Rearrangement of the E2A gene in the t (1;19) acute lymphoblastic leukemia.
Recent studies have demonstrated that the E2A gene encoding helix-loop-helix proteins E12/E47 is fused to a novel homeobox gene PBX1, as a result of the t (1;19) translocation observed in pre-B cell acute lymphoblastic leukemias. Molecular diagnostic techniques, including PCR, of the t (1;19) are now possible and provide an useful tool in conjunction with cytogenetics to identify involvement of E2A and PBX1 genes in acute lymphoblastic leukemia.
Jonveaux
P
P
INSERM U 301, Paris, France.
Berger
R
R
D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D015321:Gene Rearrangement / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*