title: [Comparative study of the effectiveness of the classical and modified Cooper protocol for breast cancer chemotherapy].
abstract: Efficiency of routine and modified Cuper procedures was studied after evaluation in saliva and urine of women with mammary gland tumor of the following parametres: alterations in dynamics of acrolein excretion with saliva, dynamics of alterations in calculated therapeutic doses of cyclophosphane administered using these procedures, dynamics of the ratio between non-metabolized cyclophosphane and its initial level in urine of the patients. Analysis of the data obtained suggest that the liver tissue enzymatic systems, involving in biotransformation of cyclophosphane, were distinctly less impaired during the modified Cuper procedure as compared with the routine course, thus corroborating advantages of the modified procedure used in chemotherapy of patients with mammary gland tumor.
authors.forename: E N
authors.initials: EN
authors.lastname: Korneva
authors.forename: V M
authors.initials: VM
authors.lastname: Shcherbakov
authors.forename: L V
authors.initials: LV
authors.lastname: Kravchenko
authors.forename: B Sh
authors.initials: BSh
authors.lastname: Chikvashvili
authors.forename: V M
authors.initials: VM
authors.lastname: Devichenskiĭ
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Semenov
authors.forename: V P
authors.initials: VP
authors.lastname: Letiagin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000493:pharmacokinetics; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000493:pharmacokinetics; D014750:Vincristine / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Sravnitel'noe issledovanie éffektivnosti klassicheskoĭ i modifitsirovannoĭ skhem Kupera pri khimioterapii raka molochnoĭ zhelezy.