[The adhesive activity of diphtheritic strains in relation to the characteristics of the infectious process they induce].
The degree of adhesiveness of 602 C. diphtheriae strains isolated from patients with different forms of diphtheria was studied on trypsinized sheep red blood cells (SRBC) used as an experimental model. The titer of bacterial suspension, i.e. its highest dilution ensuring the agglutination of 50% of SRBC, was assumed to be the index of adhesive activity. The toxigenic strains were more homogeneous with respect to the degree of their activity and proved to be moderately and highly adhesive, while among the nontoxigenic strains faintly and moderately adhesive ones prevailed. The degree of adhesiveness was not linked with the cultural biological strains variants, but depended on the form of C. diphtheriae infection. The toxigenic strains isolated from diphtheria patients were essentially more active than those isolated from carriers. Both toxigenic and nontoxigenic strains isolated in cases of prolonged carrier state (more than 4 weeks) did not differ in the degree of their adhesiveness and were essentially more active than the strains isolated from short-term carriers. The strains circulating in 10 closed groups with a high proportion of pronounced cases of carrier state (70.6% to 86.7%) were essentially more active than those circulating in 10 similar groups, but having a low proportion of pronounced cases of carrier state (6.7% to 23.8%). The conclusion was made that the degree of adhesiveness proved to be an important factor of C. diphtheriae pathogenicity, responsible for the formation of carrier state. Along with pathogenicity, this factor should be taken into consideration in the evaluation of the epidemiological importance of different sources of infection.
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D000372:Agglutination Tests; D001422:Bacterial Adhesion; D002353:Carrier State / Q000382:microbiology*; D003353:Corynebacterium diphtheriae / Q000302:isolation & purification / Q000472:pathogenicity*; D004165:Diphtheria / Q000382:microbiology*; D004912:Erythrocytes / Q000382:microbiology; D006801:Humans; D013997:Time Factors; D014069:Tonsillitis / Q000382:microbiology
Adgezivnaia aktivnost' difteriĭnykh shtammov v zavisimosti ot osobennosteĭ vyzyvaemogo imi infektsionnogo protsessa.