The effect of gangliosides upon recovery of aspartate/glutamatergic synapses in striatum after lesions of the rat sensorimotor cortex.
Changes in neuronal uptake of glutamate/aspartate were studied in the striatum after unilateral destruction of the sensorimotor cortex and injection of GM1 ganglioside. A 75% decrease of uptake of [3H]D-aspartate in the striatum ipsilateral to the cortical lesion was detected at 10 days postlesion compared to the contralateral striatum. We have demonstrated that injection of gangliosides during 10 days returned the uptake of [3H]D-aspartate to control level and compensated loss of the synapses in the striatum after the cortical lesion and thereby can prevent aberrant axonal overgrowth in the contralateral striatum.
Shifman
M
M
Department of Cryophysiology, Institute for Cryobiology and Cryomedicine, Kharkov, U.S.S.R.
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D007839:Functional Laterality; D005677:G(M1) Ganglioside / Q000494:pharmacology; D005732:Gangliosides / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
D005732:Gangliosides; D005971:Glutamates; D001224:Aspartic Acid; D005677:G(M1) Ganglioside