Humoral transplantation antibodies play a role in protracted rejection of murine renal allografts.
Murine renal allografts were studied using (C57BL/6J x A/J)F1 mice as recipients and DBA/2 mice as donors. In this strain combination, protracted rejection was noted in that the circulation was maintained in the graft for over 10 weeks. In all grafts examined after 3 weeks, mononuclear cell infiltrates were noted; in addition, all grafts had immune deposits, apparently containing transplantation antibodies, in glomeruli, tubuli and vessels. These results stressed the role of humoral immunity in protracted renal allograft rejection.
Inoue
K
K
Department of Microbiology, State University of New York, Buffalo.
Niesen
N
N
Milgrom
F
F
Albini
B
B
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology* / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D006084:Graft Rejection; D007518:Isoantibodies / Q000276:immunology*; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D051379:Mice
D000936:Antigen-Antibody Complex; D007518:Isoantibodies