HLA and venous thrombosis: a prospective study.
The frequency of venous thrombosis diagnosed by the fibrinogen uptake test and ultrasound in relation to HLA typing was examined in a prospective study of 154 patients undergoing total hip replacement. The results demonstrate an association between venous thrombosis and the presence of HLA Cw4 and B35 (being in a linkage disequilibrium with Cw4) (Cw4 34.4% and B35 27.3%, relative risk 2.531 and 1.935 respectively). These results suggest that the presence of HLA Cw4 can be regarded as one of laboratory risk factors of venous thrombosis.
Ivasková
E
E
Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
Prerovský
I
I
Riedel
M
M
Kupková
L
L
Fajtová
A
A
Stĕdrý
V
V
Slavík
M
M
D000328:Adult; D000368:Aged; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics*; D015797:HLA-B35 Antigen / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013924:Thrombophlebitis / Q000175:diagnosis / Q000235:genetics*
D006680:HLA Antigens; D015797:HLA-B35 Antigen; D015236:HLA-C Antigens; C039966:HLA-C*04 antigen