title: Effects of 60Co gamma-irradiation of mice on the temporal changes of acid phosphatase activity in spleen and liver.
abstract: Acid phosphatase activity and protein content of spleen and liver, and organ weight of whole-body 10 Gy 60Co gamma-irradiated mice were measured every four hours during a 24-hour period. In irradiated mice, in comparison with those non-irradiated, increased acid phosphatase activity in spleen related to both 1 mg of protein at 20.00I, 04.00, 08.00, 12.00, 16.00 and 20.00II and 1 g of fresh tissue at 20.00I, 08.00, 12.00, 16.00 and 20.00II; decreased weight of spleen and protein amount in spleen during the whole 24-hour period, as well as fluctuations in all the parameters measured in spleen, except the level of protein related to 1 g of fresh tissue, were observed. In irradiated mice, compared with the controls, the increased acid phosphatase activity in liver calculated per both 1 mg of protein at 24.00, 08.00 and 16.00 and 1 g of fresh tissue at 08.00 and 16.00; the decreased protein concentration in liver related to 1 g of fresh tissue and the whole organ weight at 12.00, as well as temporal changes in the protein level in liver expressed per 1 g of fresh tissue, were found. 60Co irradiation of mice influenced the acid phosphatase activity and protein concentration in liver are less than in spleen.
authors.affiliation: Department of Animal Physiology, Jagiellonian University, Cracow, Poland.
authors.forename: L
authors.initials: L
authors.lastname: Mazur
authors.forename: J
authors.initials: J
authors.lastname: Manowska
authors.forename: R
authors.initials: R
authors.lastname: Bobik
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism / Q000528:radiation effects*; D000818:Animals; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D008099:Liver / Q000201:enzymology / Q000528:radiation effects*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000528:radiation effects; D013154:Spleen / Q000201:enzymology / Q000528:radiation effects*
chemical_list: D003037:Cobalt Radioisotopes; D000135:Acid Phosphatase