title: A study of the relationship among pulpal response, microbial microleakage, and particle heterogeneity in a glass-ionomer-base material.
abstract: This investigation was designed to study the pulpal responses to glass-ionomer base materials that differ in particle size distribution. The study was carried out according to the BSI (1980) recommendations for testing restorative materials in vivo. The base materials caused more pulpal inflammation than the control material, Kalzinol, although by an indirect mechanism. A significant association was demonstrated in the statistical model between bacterial presence within the experimental cavity and pulpal inflammation. The type of restorative material has no direct association with the degree of inflammation, although the model suggests that it exerts an indirect influence via its antibacterial properties, and hence its influence on microbial microleakage. The base material, with a heterogeneous particle distribution, was associated with greater bacterial microleakage. Particle size distribution, therefore, has some effect upon bacterial microleakage, but, because of its complex effect upon several physical properties of materials, further studies are indicated.
authors.affiliation: Department of Restorative Dentistry, University of Birmingham Dental School.
authors.forename: C G
authors.initials: CG
authors.lastname: Plant
authors.forename: R S
authors.initials: RS
authors.lastname: Tobias
authors.forename: J W
authors.initials: JW
authors.lastname: Rippin
authors.forename: J W
authors.initials: JW
authors.lastname: Brooks
authors.forename: R M
authors.initials: RM
authors.lastname: Browne
mesh_terms: D000818:Animals; D003763:Dental Leakage / Q000382:microbiology*; D003782:Dental Pulp / Q000187:drug effects*; D003786:Dental Pulp Cavity / Q000382:microbiology; D003793:Dental Restoration, Permanent; D003804:Dentin / Q000187:drug effects; D003809:Dentin, Secondary; D004338:Drug Combinations; D005054:Eugenol / Q000009:adverse effects; D005289:Ferrets; D005557:Formaldehyde / Q000009:adverse effects; D005899:Glass Ionomer Cements / Q000009:adverse effects*; D008297:Male; D010316:Particle Size; D011671:Pulpitis / Q000139:chemically induced*; D013997:Time Factors; D015034:Zinc Oxide / Q000009:adverse effects
chemical_list: D004338:Drug Combinations; D005899:Glass Ionomer Cements; D005557:Formaldehyde; D005054:Eugenol; C003799:N2 Dental Cement; D015034:Zinc Oxide