[The effect of bioadhesiveness of viscous solutions with naphazoline hydrochloride on the elimination of the drug from the eye of swine].
Solutions of sodium carboxymethylamylopectine, tragant, hydroxyethylcellulose, polyvinylalcohol, polyacrylic ester D 339, polyacrylic ester D 340 and polyacrylic acid, all of the same viscosity and with the same concentration of naphazoline hydrochloride, were applied on the isolated eye of pig. After sink the eye in a solution of sodium chloride the elimination of the drug from the eye was investigated. The results were compared with the bioadhesion of the viscous solutions measured ex vivo on the intestine of pigs. There were correlations between the eliminated mass after 5 min, after 30 min and the bioadhesion. Furthermore the calculated initial elimination constant was indirect proportional to the bioadhesion. The elimination of the drug between 5 and 30 min was independent on the bioadhesion.
Dittgen
M
M
Fachrichtung Pharmazie, Ernst-Moritz-Arndt-Universität Greifswald.
Oestereich
S
S
Eckhardt
D
D
D000268:Adhesiveness; D000818:Animals; D005079:Excipients; D005123:Eye / Q000378:metabolism*; D066298:In Vitro Techniques; D009278:Naphazoline / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012996:Solutions; D013552:Swine; D014783:Viscosity
D005079:Excipients; D012996:Solutions; D009278:Naphazoline
Einfluss der Bioadhäsivität von Schleimen auf die Elimination von Naphazolinhydrochlorid vom Auge des Hausschweines.