[Role of the liver in the regulation of circadian rhythm of blood iron in rats].
In experiments with Wistar rats there was discovered statistically significant circadian rhythm of serum iron concentration reaching its maximum in the evening, minimum--early in the morning, and having an amplitude of at least 20% of the mesor. The reciprocal interrelations between circadian cycles of iron content in blood and liver were also found. The synchronization of blood iron level with lipid peroxidation products in membranous liver structures, as well as serum alanine aminotransferase activity, and their inversion with respect to the circadian rhythms of liver RES absorption ability and liver iron content are considered to be a proof of liver participation in regulation of iron exchange temporal organization in rats.
Barkova
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EN
Chesnokov
E V
EV
Korkin
A L
AL
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002940:Circadian Rhythm; D006651:Histocytochemistry; D007501:Iron / Q000032:analysis / Q000097:blood*; D007728:Kupffer Cells / Q000378:metabolism / Q000502:physiology; D015227:Lipid Peroxidation; D008099:Liver / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007501:Iron; D000410:Alanine Transaminase
Rol' pecheni v reguliatsii tsirkadiannogo ritma sideremii u krys.