Aryloxyacetic acid diuretics with uricosuric activity. II. Substituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids and the related compounds.
Di- and tri-substituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids, and 4-oxo-3-phenyl-4H-furo[2,3-h]-[1]benzopyran-8-carboxylic acid were synthesized and tested for natriuretic and uricosuric activities. Among the compounds tested, 3,5-disubstituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids (6c-f, h, n and x) showed potent natriuretic and uricosuric activities, whereas 4-oxo-3-phenyl-4H-furo[2,3-h][1]benzopyran-8-carboxylic acid (6dd) possessed only potent natriuretic activity. The structure-activity relationships are also discussed.
Kitagawa
M
M
Research Institute, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Yamamoto
K
K
Katakura
S
S
Kanno
H
H
Yamada
K
K
Nagahara
T
T
Tanaka
M
M
D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D004232:Diuretics / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014528:Uricosuric Agents / Q000138:chemical synthesis / Q000494:pharmacology*
D001578:Benzopyrans; D004232:Diuretics; D014528:Uricosuric Agents