Tumour evolution in rats monitored by changes to serum and lipoproteins.
The biochemical, physicochemical and magnetic resonance (MR) properties of rat serum allow tumour evolution to be monitored. Serum from female Fischer rats injected with rat mammary adenocarcinoma cells contained a low-density lipoprotein (LDL)-like lipoprotein and decreased high-density lipoprotein levels compared with normal rat serum. Increases in secondary tumour burden coincided with enlarged LDL-like particles, altered MR properties and elevation of serum triglyceride. By fucosidase treating metastatic R13762 cells prior to injection, not only was metastatic capacity retarded, but serum lipoproteins were also altered. These physicochemical alterations suggest an intricate relationship between both primary and secondary tumour burdens and the serum lipoprotein profile.
Wright
L C
LC
Cancer Medicine, University of Sydney, Australia.
May
G L
GL
Mackinnon
W B
WB
Gregory
P
P
Holmes
K T
KT
Dyne
M
M
Sullivan
D
D
Mountford
C E
CE
D000230:Adenocarcinoma / Q000097:blood*; D000818:Animals; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D005260:Female; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008325:Mammary Neoplasms, Experimental / Q000097:blood*; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000097:blood*; D009368:Neoplasm Transplantation; D010316:Particle Size; D010743:Phospholipids / Q000097:blood; D051381:Rats; D011916:Rats, Inbred F344; D014280:Triglycerides / Q000097:blood; D014407:Tumor Cells, Cultured
D002788:Cholesterol Esters; D005227:Fatty Acids; D008055:Lipids; D008074:Lipoproteins; D009363:Neoplasm Proteins; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol