15 alpha-hydroxylation of 13-ethyl-gon-4-ene-3,17-dione using a hyphal fungus immobilized in calcium alginate gel beads.
Calcium alginate-entrapped mycelium of Penicillium raistrickii i 477 was used for the 15 alpha-hydroxylation of 13-ethyl-gon-4-ene-3,17-dione. The system was tested in 10 batches during 40 days of operation, the catalytic activity could be completely regenerated by incubation in a nutrient medium between several batches.
Schlosser
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Institut für Mikrobiologie, Biologische Fakultät, Friedrich-Schiller-Universität Jena.
Schmauder
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D000464:Alginates; D004800:Enzymes, Immobilized; D005069:Evaluation Studies as Topic; D006067:Gonanes / Q000378:metabolism*; D008863:Microspheres; D009652:Norpregnenes / Q000378:metabolism*; D010407:Penicillium / Q000378:metabolism*; D045167:Progesterone Congeners / Q000378:metabolism*
D000464:Alginates; D004800:Enzymes, Immobilized; D006067:Gonanes; D009652:Norpregnenes; D045167:Progesterone Congeners; C033273:Gestodene; C055308:13-ethyl-gon-4-ene-3,17-dione