title: [The effect of acetylcysteine on the antioxidant system in an experimental toxic lesion of the liver].
abstract: The liver damage by CCl4 in albino rats was followed by a drastic activation of lipid peroxidation processes and suppression of most components of the antioxidant system. The administration of acetylcysteine to the affected animals exerted the positive effect which manifested itself in a decrease of lipid peroxidation products content in the blood plasma and liver and in the partial normalization of the antioxidant protection system.
authors.forename: Ia I
authors.initials: IaI
authors.lastname: Gonskiĭ
authors.forename: M M
authors.initials: MM
authors.lastname: Korda
authors.forename: I N
authors.initials: IN
authors.lastname: Klishch
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D000111:Acetylcysteine
vernacular_title: Vliianie atsetiltsisteina na antioksidantnuiu sistemu pri éksperimental'nom toksicheskom porazhenii pecheni.