Redispersible dry emulsion system as novel oral dosage form of oily drugs: in vivo studies in beagle dogs.
The absorption characteristics of vitamin E acetate (VEA) formulated into a dry emulsion system after its oral administration to beagle dogs were determined and compared to those of two different dosage forms (an oily mixture of the drug with cottonseed oil and an oil (drug)-in-water emulsion). The three dosage forms were administered in a crossover fashion to six nonfasting subjects, and the drug absorption was assessed from the plasma concentration of the major metabolite (free vitamin E). VEA formulated in the dry emulsion was rapidly absorbed, which suggested that a considerable amount was released as reformed emulsion droplets in the gastrointestinal tract as well as in water in vitro. Based on the analysis of variance, no significant differences in bioavailability parameters (AUC, Cmax or Tmax) were observed among the three dosage forms.
Takeuchi
H
H
Gifu Pharmaceutical University, Japan.
Sasaki
H
H
Niwa
T
T
Hino
T
T
Kawashima
Y
Y
Uesugi
K
K
Ozawa
H
H
D000284:Administration, Oral; D000818:Animals; D004285:Dogs; D004655:Emulsions; D007408:Intestinal Absorption; D008297:Male; D009821:Oils / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014810:Vitamin E / Q000008:administration & dosage / Q000493:pharmacokinetics
D004655:Emulsions; D009821:Oils; D014810:Vitamin E