A comparative study on the thermoregulatory effects of prazosin, dihydrobenzperidol and nifedipin on 2,4-dinitrophenol induced hyperthermia in rabbits.
1. Thermal responses to prazosin (PRA) and dihydrobenzperidol (DHBP) (0.75 mg/kg) or nifedipin (ADA: 0.05 mg/kg) administered intravenously were investigated in hyperthermic rabbits. 2. Hyperthermia produced by dinitrophenol (DNP; 20 mg/kg; i.v.), resulted from stimulation of the metabolic rate. 3. All the investigated drugs; i.e. PRA, DHBP, ADA reduced the hyperthermic activity of DNP. Contrary to DHBP and ADA, PRA did not change DNP--stimulated metabolism. 4. Possible mechanisms responsible for prazosin antihyperthermizing action are discussed.
Szreder
Z
Z
Department of Pharmacology, Medical Academy, Gdańsk, Poland.
Gagało
I
I
D019297:2,4-Dinitrophenol; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004140:Dinitrophenols / Q000494:pharmacology*; D004329:Droperidol / Q000494:pharmacology*; D005260:Female; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology*; D011817:Rabbits; D012881:Skin Temperature / Q000187:drug effects
D004140:Dinitrophenols; D009543:Nifedipine; D004329:Droperidol; D019297:2,4-Dinitrophenol; D011224:Prazosin