Morphine influence on adenylate cyclase activity in peripheral blood lymphocytes of alcoholic patients.
The effect of morphine on adenylate cyclase activity in lymphocytes was tested in 20 normal controls, 16 alcoholics in withdrawal and 9 sober alcoholics. Alcoholics in withdrawal were characterized by a significantly increased stimulatory effect of morphine, whereas sober alcoholics showed an inhibitory effect. The morphine effect was abolished by naloxone and correlated with the severity of withdrawal and alcohol intoxication.
Gamaleya
N B
NB
All-Union Scientific Research Centre for Medical and Biological Problems of Narcology, Moscow, U.S.S.R.
Vekshina
N L
NL
Nebarakova
T P
TP
Tronnikov
S I
SI
Anokhina
I P
IP
D000262:Adenylyl Cyclases / Q000097:blood*; D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000201:enzymology; D000437:Alcoholism / Q000201:enzymology* / Q000534:rehabilitation; D004789:Enzyme Activation; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology
D009270:Naloxone; D009020:Morphine; D000262:Adenylyl Cyclases