title: Immunological studies in Bloom's syndrome. A follow-up report.
abstract: Longitudinal immunological studies were performed in five patients with Bloom's syndrome. Serum IgG concentration showed no age-related increase. IgA levels were below the 10th percentile in childhood, but rose to normal in all but one. IgM was decreased in four patients at diagnosis and remained so in three of them. Cellular immunity results were very variable, even within one patient. An immunologic attrition was not demonstrated.
authors.affiliation: Department of Pediatrics, University Hospital, Nijmegen, The Netherlands.
authors.forename: C M
authors.initials: CM
authors.lastname: Weemaes
authors.forename: J A
authors.initials: JA
authors.lastname: Bakkeren
authors.forename: A
authors.initials: A
authors.lastname: Haraldsson
authors.forename: D F
authors.initials: DF
authors.lastname: Smeets
mesh_terms: D001816:Bloom Syndrome / Q000235:genetics / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008137:Longitudinal Studies; D008297:Male
chemical_list: D007136:Immunoglobulins