title: Nucleotide sequence of cDNA coding for mink proopiomelanocortin (POMC) and its comparative analysis with POMC mRNA primary structures from pituitaries of other animal species and man.
abstract: cDNA for proopiomelanocortin (POMC) of mink has been cloned and sequenced. A comparative analysis of the primary structures of mRNAs coding for proopiomelanocortins of eight animal species and man has been performed. The analysis has revealed conserved and variable POMC mRNA regions. High variability of some of the regions is suggested to be due to the peculiarities of their structural organization. A putative mechanism responsible for the mutations in variable regions is proposed. A tree of the evolutionary relations of POMC has been developed.
authors.affiliation: Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences.
authors.forename: N P
authors.initials: NP
authors.lastname: Mertvetsov
authors.forename: V A
authors.initials: VA
authors.lastname: Karginov
authors.lastname: Golovin SJa
authors.forename: A A
authors.initials: AA
authors.lastname: Bondar
authors.forename: I V
authors.initials: IV
authors.lastname: Morozov
authors.forename: S M
authors.initials: SM
authors.lastname: Zelenin
authors.forename: V M
authors.initials: VM
authors.lastname: Blinov
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D000882:Haplorhini; D006801:Humans; D051379:Mice; D008907:Mink / Q000235:genetics*; D008969:Molecular Sequence Data; D010902:Pituitary Gland / Q000737:chemistry*; D011333:Pro-Opiomelanocortin / Q000096:biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000737:chemistry* / Q000302:isolation & purification; D051381:Rats; D012474:Salmon; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D013552:Swine; D014981:Xenopus
chemical_list: D012333:RNA, Messenger; D011333:Pro-Opiomelanocortin; D004247:DNA