[Metabolic N- and S-oxygenation of dokloxytepin in vitro].
Dokloxytepin in the medium of the induced monooxygenase system of the microsomal fraction of the liver of the rat, rabbit and mice is metabolized into three metabolites: two identical, i.e., N-oxide and 5-sulfoxide, and a third different one. In the rat and rabbit it is the hitherto unknown metabolite M1, and in the mouse S,N-dioxide of dokloxytepin. The metabolites were identified by thin-layer chromatography by comparing with synthetic standards.
Helia
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Katedra biochemie a mikrobiologie farmaceutické fakulty Univerzity Komenského, Bratislava.
Pauliková
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I
D000818:Animals; D003988:Dibenzothiepins / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D010084:Oxidation-Reduction; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D003988:Dibenzothiepins; C019360:docloxythepin
Metabolická N- a S-oxygenace dokloxytepinu in vitro.