Connections between translation, transcription and replication error-rates.
The analysis of published data from E coli suggests that in all three processes of translation, transcription, and replication, a minority of errors are produced by sub-classes of error-prone components. These add to the basal level of errors a noise of about 10 to 30%. Each one of the three processes contributes to the noisiness of the two others in a loose manner: a large increase in one error-rate produces a moderate increase in another error-rate. The strongest influence is that of transcription on translation errors. There it is possible that a majority of the misacylation errors are produced during the encounter of a correct amino acyl-tRNA ligase with a mistranscribed tRNA. Extreme mutator mutants are expected to produce a moderate increase in translation errors.
Ninio
J
J
Institut Jacques-Monod, Paris, France.
D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics; D008433:Mathematics; D009154:Mutation; D014176:Protein Biosynthesis / Q000235:genetics*; D012346:RNA, Transfer, Amino Acyl / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*
D012346:RNA, Transfer, Amino Acyl