title: Thiazolylidene-ketonitriles are efficient inhibitors of electron transport in reaction centers from photosynthetic bacteria.
abstract: Thiazolylidene-ketonitriles are efficient inhibitors of photosynthetic electron flow in reaction centers from either Rhodobacter sphaeroides or Rhodobacter capsulatus. Some compounds of this class exhibit a higher inhibitor potency in the bacterial system as compared to photosystem II. Up to now, photosystem II inhibitors were generally less active in photosynthetic bacteria. An azido-thiazolylidene-ketonitrile upon illumination almost exclusively tags the L-subunit in the bacterial reaction center.
authors.affiliation: Lehrstuhl Biochemie der Pflanzen, Ruhr-Universität, Bundesrepublik Deutschland.
authors.forename: W
authors.initials: W
authors.lastname: Oettmeier
authors.forename: S
authors.initials: S
authors.lastname: Preusse
authors.forename: M
authors.initials: M
authors.lastname: Haefs
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D004579:Electron Transport / Q000187:drug effects; D008969:Molecular Sequence Data; D009570:Nitriles / Q000494:pharmacology*; D045322:Photosynthetic Reaction Center Complex Proteins / Q000037:antagonists & inhibitors*; D016354:Rhodobacter capsulatus / Q000378:metabolism*; D012242:Rhodobacter sphaeroides / Q000378:metabolism*; D012241:Rhodopseudomonas / Q000378:metabolism*; D012689:Sequence Homology, Nucleic Acid; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D009570:Nitriles; D045322:Photosynthetic Reaction Center Complex Proteins; D013844:Thiazoles