Influence of iodide on cataractogenesis in Emory mice.
Cataract development was studied in two groups of Emory mice by periodical biomicroscopic examinations (beginning at 5 weeks of age) and by a final evaluation of water-soluble SH groups in the lenses. The experimental group was given 256 micrograms iodide/kg body weight with the drinking water throughout the study. The untreated control group received tap water. Iodide treatment induced a delay of cataract formation, resulting in a significant reduction of the time to progress from cataract degree 1 to degree 2 (iodide-treated group 12.8 +/- 1.7 weeks, untreated group 9.9 +/- 1.0 weeks; p less than 0.025). A still significant difference in the degree of cataract was also found between the two groups at week 47 of age. No difference was found in the content of water-soluble SH groups. The results are discussed in relation to the known antioxidant and .OH-scavenging effect of iodide and to the oxidative changes in the lens occurring during progression of cataract development.
Buchberger
W
W
Department of Chemistry, Paracelsus Institute, Bad Hall, Austria.
Winkler
R
R
Moser
M
M
Rieger
G
G
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight; D002386:Cataract / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D007908:Lens, Crystalline / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains; D011863:Radioimmunoassay; D011897:Random Allocation; D012974:Sodium Iodide / Q000008:administration & dosage*; D013438:Sulfhydryl Compounds / Q000032:analysis; D013974:Thyroxine / Q000097:blood
D013438:Sulfhydryl Compounds; D012974:Sodium Iodide; D013974:Thyroxine