A case of pyrazinamide-associated myoglobinuric renal failure.
A 50-year-old man developed myoglobinuric renal failure after taking pyrazinamide. Both serum and urine myoglobin levels were elevated and tubulo-interstitial nephropathy was demonstrated on renal biopsy. After pyrazinamide was discontinued, the myoglobin concentrations were normalized and his renal function ameliorated. The rhabdomyolysis was considered to be caused by pyrazinamide. To our knowledge, this is the first reported case of rhabdomyolysis associated with pyrazinamide.
Namba
S
S
Department of Internal Medicine, Japanese Red Cross Medical Center, Tokyo.
Igari
T
T
Nishiyama
K
K
Hashimoto
K
K
Takemura
T
T
Kimura
K
K
D058186:Acute Kidney Injury / Q000209:etiology*; D003402:Creatine Kinase / Q000097:blood; D003404:Creatinine / Q000097:blood; D004977:Ethambutol / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood; D009212:Myoglobinuria / Q000139:chemically induced; D011718:Pyrazinamide / Q000009:adverse effects* / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000150:complications; D014376:Tuberculosis / Q000188:drug therapy; D014527:Uric Acid / Q000097:blood
D009211:Myoglobin; D014527:Uric Acid; D011718:Pyrazinamide; D004977:Ethambutol; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase