title: Two point analysis 15-minute 14C-urea breath test for diagnosing Helicobacter pylori infection.
abstract: The value of a two point analysis (double sample) 14C-urea breath test in diagnosing Helicobacter pylori (HP) infection in patients with suspected acid peptic disease has been studied and compared to histology and to a rapid agar plate urease test in 76 patients. Using the histological finding of HP as the gold standard, the 14C-breath test was positive in 59 of the 61 histologically confirmed infected patients and in 3 of the 15 noninfected ones, giving a sensitivity of 97% and specificity of 80%. In 12 patients, a smaller dose of 3 mu Ci 14C-urea was used. The results correlated well with those in whom the higher dose of 10 mu Ci was used. We conclude that a two point 14C-urea breath test with analysis at 5 and 15 min is effective in diagnosing HP infection thus obviating the need for endoscopy and biopsy.
authors.affiliation: Gastroenterology Unit, Meir Hospital, Kfar Saba, Israel.
authors.forename: B H
authors.initials: BH
authors.lastname: Novis
authors.forename: G
authors.initials: G
authors.lastname: Gabay
authors.forename: G
authors.initials: G
authors.lastname: Leichtmann
authors.forename: M
authors.initials: M
authors.lastname: Peri
authors.forename: J
authors.initials: J
authors.lastname: Bernheim
authors.forename: I S
authors.initials: IS
authors.lastname: Pomeranz
mesh_terms: D001944:Breath Tests / Q000379:methods*; D002250:Carbon Radioisotopes; D015169:Colony Count, Microbial / Q000379:methods; D005756:Gastritis / Q000175:diagnosis; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000201:enzymology; D016480:Helicobacter pylori / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D010437:Peptic Ulcer / Q000175:diagnosis; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013272:Stomach Diseases / Q000175:diagnosis*; D014510:Urease / Q000032:analysis*
chemical_list: D002250:Carbon Radioisotopes; D014510:Urease