[Morphological evidence of the possible role of cytochrome P-450 in the development of an autoimmune process in the liver].
Morphological alterations in rat's liver during lipid peroxidation induction by paraqat were studied. Infiltration of liver by lymphocytes, macrophages and plasma cells was studied. On ultrastructure level profound extension of rough reticulum cistern and destruction of mitochondrial cristae were revealed by immunohistochemical methods. Cytochrom P-450 was localized on the fibrin fibers.
Gladyshev
Iu V
IuV
Kolesnikov
S I
SI
Semeniuk
A V
AV
Sviridov
A V
AV
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure*; D008107:Liver Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D010269:Paraquat; D051381:Rats
D003577:Cytochrome P-450 Enzyme System; D010269:Paraquat
Morfologicheskie svidetel'stva vozmozhnoĭ roli tsitokhroma P-450 v razvitii autoimmunnogo protsessa v pecheni.