title: Prognostic significance of proteinuria one year after onset of diarrhea-associated hemolytic-uremic syndrome.
abstract: We examined the prognostic value of changes in the amount of proteinuria, measured as protein/creatinine ratios in early-morning urine samples, in 40 children who had had diarrhea-associated hemolytic-uremic syndrome. One year after diagnosis, 87% of those who seemed to have fully recovered had normal urinary protein/creatinine ratios, compared with none of those with poor outcomes (p less than 0.001). None of those with poor outcomes achieved normal protein/creatinine ratios during follow-up to a maximum of 5 1/2 years, but 93% of those who made a full clinical recovery no longer had proteinuria. Measurement of the protein/creatinine ratio in an early-morning sample of urine is a simple, cost-effective, and noninvasive means of monitoring the progress of patients with diarrhea-associated hemolytic-uremic syndrome, provided that a technique sensitive at low protein concentrations is employed.
authors.affiliation: Department of Nephrology, Children's Hospital, Birmingham, England.
authors.forename: D V
authors.initials: DV
authors.lastname: Milford
authors.forename: R H
authors.initials: RH
authors.lastname: White
authors.forename: C M
authors.initials: CM
authors.lastname: Taylor
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine*; D003967:Diarrhea / Q000209:etiology / Q000652:urine; D005919:Glomerular Filtration Rate; D006463:Hemolytic-Uremic Syndrome / Q000150:complications / Q000652:urine*; D006801:Humans; D007223:Infant; D011379:Prognosis; D011446:Prospective Studies; D011507:Proteinuria / Q000652:urine*
chemical_list: D003404:Creatinine