Immunohistochemical localization of S-100 protein and its subunits in melanotic lesions in the oral mucosa and skin.
Immunohistochemical localization of S-100 protein, S-100 alpha and beta subunits was examined in 23 pigmented nevi, 20 malignant melanomas and 8 metastatic melanomas originating from the oral mucosa and skin. Primary oral mucosal melanomas demonstrated no beta subunit immunoreactivity while one metastatic lesion from oral melanoma that showed only a small number of melanoma cells reacted with the beta subunit. In contrast, most cutaneous melanomas and their metastatic lesions showed immunoreaction with the S-100 beta subunit. As for pigmented nevi, immunoreactions with the three antibodies were frequently detected regardless of the site. The differences in the expression of S-100 protein beta subunit between cutaneous and mucosal melanomas may be related to differences in inductive interactions between the melanoma cells and the connective tissues and skin and mucosa.
Fujita
S
S
Department of Oral Pathology, Nagasaki University, School of Dentistry, Japan.
Takahashi
H
H
Tsuda
N
N
Okabe
H
H
D002467:Cell Nucleus / Q000737:chemistry; D003593:Cytoplasm / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D008543:Melanins / Q000032:analysis; D008545:Melanoma / Q000737:chemistry* / Q000473:pathology; D009061:Mouth Mucosa / Q000737:chemistry / Q000473:pathology; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000473:pathology; D009508:Nevus, Pigmented / Q000737:chemistry* / Q000473:pathology; D010446:Peptide Fragments / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis*; D012878:Skin Neoplasms / Q000737:chemistry* / Q000473:pathology
D008543:Melanins; D010446:Peptide Fragments; D009418:S100 Proteins