title: Ultrastructure of the rat hippocampus after isobaric respirative hyperoxia.
abstract: After exposing rats to an environment of isobaric hyperoxia, the ultrastructural alterations of the hippocampus were studied. No major alterations were found in the nerve cells. Of importance was the moderate osmiophilia and the spindle-like transformation of the mitochondria. Vacuolated synapses and neuraxons were found, containing amorphous material. Astrocytic perivascular end feet were found vacuolated in many places. Many endothelial cells of the capillaries presented high osmiophilia, which sometimes prevented structural details. Quantitatively, the findings were proportionally related to the time of exposure in the pure oxygen atmosphere (24, 48 and 65 hours).
authors.affiliation: Laboratory of Histology-Embryology, Faculty of Medicine, University of Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Manthos
authors.forename: M
authors.initials: M
authors.lastname: Tsolaki
authors.forename: K
authors.initials: K
authors.lastname: Kaidoglou
authors.forename: A
authors.initials: A
authors.lastname: Alvanou
authors.forename: K
authors.initials: K
authors.lastname: Hatjinikolaou
authors.forename: A
authors.initials: A
authors.lastname: Hatjiagorakis
authors.forename: M
authors.initials: M
authors.lastname: Giala
authors.forename: C
authors.initials: C
authors.lastname: Foroglou
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000648:ultrastructure; D006624:Hippocampus / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D010100:Oxygen / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D010100:Oxygen