[Investigations of the immunomodulatory effect of cyanobacterial extracts].
Resulting from the knowledge that cyanobacteria (blue-green algae) are able to produce pharmacologically active substances the aqueous extracts from several cyanobacteria species and strains (Microcystis aeruginosa, Synechocystis aquatilis, Oscillatoria redekei, Anabaena flos-aque, Aphanizomenon flos-aquae, Oscillatoria rubescens, Oscillatoria tenuis) were tested for their immunomodulating activity. Extracts from Oscillatoria redekei 051, Oscillatoria tenuis 01 and Synechocystis aquatilis 428 caused an immunosuppression. They inhibited not only the incorporation of 3H-thymidine into mitogen stimulated lymphocytes but reduced also the number of plaque-forming cells of mice as shown by hemolysis-plaque-assay. Only extracts from Oscillatoria redekei 051 did not show any cytotoxic effects in lymphocyte cytotoxic test. This may be an evidence for a specific action on the proliferation of lymphocytes.
Effmert
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Fachrichtung Pharmazie, Lehrstuhl Pharmazeutische Biologie, Ernst-Moritz-Arndt-Universität Greifswald.
Mundt
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Teuscher
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D000917:Antibody Formation; D002470:Cell Survival / Q000187:drug effects; D000458:Cyanobacteria / Q000276:immunology*; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology*; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000008:administration & dosage
D007155:Immunologic Factors; D010835:Phytohemagglutinins
Untersuchungen zur immunmodulatorischen Wirkung von Extrakten aus Cyanobakterien.