title: Phase II evaluation of amonafide in renal cell carcinoma. A Southwest Oncology Group study.
abstract: Twenty four patients with advanced renal cell carcinoma were treated in a phase II trial with amonafide 300-450 mg/m2/day on days 1-5 every 21 days. There were no responders, 6 patients had stable disease, 14 experienced progressive disease and 4 were assumed to be non-responders as no evaluation was performed. There were no fatal toxicities although 8 patients had grade 3 or 4 granulocytopenia, 1 patient had grade 4 thrombocytopenia. Other toxicities included grade 3 diarrhea in 1 patient, grade 3 myopathy in 1 patient, severe nausea and vomiting in 1 patient and a facial rash, possibly a hypersensitivity reaction, in 1 patient. The median survival is 7.5 months. At this dosage and schedule, there is no evidence that amonafide has meaningful anti-tumor activity in patients with advanced renal cell carcinoma.
authors.affiliation: Puget Sound Oncology Consortium, Seattle, WA.
authors.forename: C S
authors.initials: CS
authors.lastname: Higano
authors.forename: P
authors.initials: P
authors.lastname: Goodman
authors.forename: J B
authors.initials: JB
authors.lastname: Craig
authors.forename: J A
authors.initials: JA
authors.lastname: Kish
authors.forename: S E
authors.initials: SE
authors.lastname: Rivkin
authors.forename: M
authors.initials: M
authors.lastname: Wolf
authors.forename: E D
authors.initials: ED
authors.lastname: Crawford
mesh_terms: D000225:Adenine; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007094:Imides; D007546:Isoquinolines / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D053644:Naphthalimides; D063065:Organophosphonates
chemical_list: D000970:Antineoplastic Agents; D007094:Imides; D007546:Isoquinolines; D053644:Naphthalimides; D063065:Organophosphonates; C037020:amonafide; D000225:Adenine