[The search for new antiparasitic agents. 9. The anthelmintic activity of halogen-containing sulfonamidobenzamides].
The results of preclinical trials of 28 new compounds of haloid-containing sulfamidobenzamides with low toxicity are presented. The trials on a hymenolepiasis model showed that effectiveness of N-(2,5-dichlorophenyl)-2/(3-nitro-4-chlorophenyl) sulfonylamino/-5-bromobenzamide was similar to that of the well-known drug niclosamide. In the trials on an opisthorchiasis model, 2 compounds were shown to be highly effective, and on a trichocephaliasis model 5 compounds showed a high activity.
Mikhaĭlitsyn
F S
FS
Lebedeva
M N
MN
Baiandina
D G
DG
Kozyreva
N P
NP
Lychko
N D
ND
Bolotina
L A
LA
Drusviatskaia
S K
SK
Naĭdenova
A S
AS
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006219:Halogens / Q000627:therapeutic use; D006373:Helminthiasis / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000627:therapeutic use*
D000871:Anthelmintics; D001549:Benzamides; D006219:Halogens; D013449:Sulfonamides
Izyskanie novykh protivoparazitarnykh sredstv. 9. Protivogel'mintnaia aktivnost' galoidsoderzhashchikh sul'fonamidobenzamidov.