[The use of bead cellulose for controlled drug liberation. 3. The ion exchange capacity of bead cellulose and bead cellulose derivatives].
Methods are represented for the preparation of the ionic derivatives dihydrogen-phosphate bead cellulose and carboxymethyl bead cellulose from pure, swollen bead cellulose. The degree of substitution can be varied by changing the extent of swelling of the parent bead cellulose and the amount of reactant. The products exhibit similar physical properties (swelling weight, porosity, bed volume and spherical shape) like pure, unsubstituted bead cellulose. The ion exchange capacity and pK values of bead cellulose derivatives were measured by a modified acid-base titration method. The tendency of varying the physical properties in relation to the degree of substitution is discussed.
Wolf
B
B
Sektion Biowissenschaften, Lehrstuhl Pharmazeutische Technologie, Universität Leipzig.
Finke
I
I
D002266:Carboxymethylcellulose Sodium; D002482:Cellulose / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D007474:Ion Exchange; D008863:Microspheres
D003692:Delayed-Action Preparations; D002482:Cellulose; D002266:Carboxymethylcellulose Sodium
Einsatz der Perlcellulose zur kontrollierten Arzneistoff-Freigabe. 3. Mitteilung: Untersuchungen zur lonenaustauschkapazität von Perlcellulose und Perlcellulose Derivaten.