Influence of neurotransplantation on rats' behavior with different conditions of reinforcement.
Recently, we have reported a marked rat lateralization in the T-maze choice. Embryonic rat tissue from neocortex, hippocampus, hypothalamus and amygdala was transplanted into intact rat brains in various combinations: 1) neocortex and hypothalamus (Neo + Hyp); 2) hippocampus and amygdala (Hipp + Amyg); 3) neocortex and hippocampus (Neo + Hipp); and 4) hypothalamus and amygdala (Hyp + Amyg). Once under conditions in which reinforcement was equally qualitative and equally probable, rats in all groups chose the T-maze arm contralateral to the side of implantation. In a second set of experiments, rats were presented a choice between quality and probability of reinforcement. The right arm of the T-maze contained a cup of water 33% of the time (high-quality but low-probability reinforcement). The left sleeve contained a solution of 0.15% quinine in water 100% of the time (low quality but high probability of reinforcement). Rats that received Neo + Hyp transplants chose the T-maze arm that always contained a drink cup with water significantly more often than they chose the arm that always contained the drink cup with quinine solution. Rats that received Hipp + Amyg transplants chose the arm containing the drink cup with quinine solution much more often than the arm that sometimes contained a cup of water. Rats with transplanted Neo + Hyp generally were more active than rats with transplanted Hipp + Amyg. These data suggest that the behavior of rats can be affected by selective transplantation of different brain tissue.
Zukhar
A V
AV
Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences USSR, Moscow.
Mikhailova
N G
NG
Ermakova
I V
IV
Loseva
E V
EV
D000679:Amygdala / Q000637:transplantation; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D016380:Brain Tissue Transplantation / Q000502:physiology*; D002540:Cerebral Cortex / Q000637:transplantation; D003216:Conditioning, Operant / Q000502:physiology*; D005260:Female; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D006624:Hippocampus / Q000637:transplantation; D007031:Hypothalamus / Q000637:transplantation; D011247:Pregnancy; D011803:Quinine / Q000494:pharmacology; D051381:Rats; D012054:Reinforcement, Psychology
D011803:Quinine