The sequestration of 111-In-labelled autologous platelets and the efficiency of splenectomy.
The main information is the excellent correlation between the site of sequestration of autologous platelets (the use of 111-indium allows autologous labelling even in case of severe thrombocytopenia) and the efficiency of splenectomy. From 76 cases with splenic sequestration studied 2 to 10 weeks after splenectomy, an excellent increase of the platelet count (higher than 300 10(9)/l) was observed in 65 cases, a moderate increase (100-300) in 6, a failure in 5. In contrast, in the 16 cases with hepatic sequestration, only one success did occur, and failure (platelet count lower than 100) occurred 15 times. Beyond the 6th month, in spite of some relapses, the prediction remains excellent. From the 67 evaluated cases with initial splenic sequestration, 58 have a platelet count higher than 100 10(9)/l. From the 14 cases with hepatic sequestration, 13 have, at long term, less than 100 10(9)/l platelets.
Najean
Y
Y
Service de Médecine Nucléaire de l'Hôpital Saint-Louis, Paris, France.
Rain
J D
JD
Dufour
V
V
D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D007205:Indium Radioisotopes; D008099:Liver / Q000503:physiopathology; D010976:Platelet Count / Q000379:methods; D011237:Predictive Value of Tests; D011696:Purpura, Thrombocytopenic / Q000097:blood* / Q000601:surgery; D013154:Spleen / Q000503:physiopathology; D013156:Splenectomy
D007205:Indium Radioisotopes