title: Co-expression of the proto-oncogene fos (c-fos) and an embryonic interferon (ovine trophoblastin) by sheep conceptuses during implantation.
abstract: Expression of the c-fos proto-oncogene by ovine conceptuses was analyzed by Northern and slot blots and indirect immunohistofluorescence in relation to the expression of the embryonic interferon-alpha (oTP) during implantation. c-fos was expressed initially in the trophoblast, and then in the allantois, when this tissue began to develop (day 17). In the embryonic tissues, the c-fos proto-oncogene was weakly expressed up to day 22 and increased thereafter. In the trophoblast, the expression of c-fos proto-oncogene was transient, occurring when the oTP gene was transcribed at a maximal level at the beginning of implantation (days 14-15), and decreased thereafter, following the pattern of oTP gene expression. This decline is due essentially to the arrest of c-fos and oTP gene expression by the trophoblastic cells which established cellular contacts with the uterine epithelium during the implantation process.
authors.affiliation: Unité Endocrinologie de l'Embryon, Station de Physiologie Animale, Jouy-en-Josas, France.
authors.forename: F
authors.initials: F
authors.lastname: Xavier
authors.forename: M
authors.initials: M
authors.lastname: Guillomot
authors.forename: M
authors.initials: M
authors.lastname: Charlier
authors.forename: J
authors.initials: J
authors.lastname: Martal
authors.forename: P
authors.initials: P
authors.lastname: Gaye
mesh_terms: D000199:Actins / Q000032:analysis; D000818:Animals; D010064:Embryo Implantation / Q000502:physiology*; D005260:Female; D015870:Gene Expression; D006651:Histocytochemistry; D007150:Immunohistochemistry; D007370:Interferon Type I / Q000096:biosynthesis; D009693:Nucleic Acid Hybridization; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000096:biosynthesis*; D011270:Pregnancy, Animal / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000032:analysis / Q000302:isolation & purification; D012756:Sheep / Q000196:embryology*; D013997:Time Factors; D014327:Trophoblasts / Q000502:physiology
chemical_list: D000199:Actins; D007370:Interferon Type I; D011257:Pregnancy Proteins; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; C020947:interferon tau