Influence of probenecid on P-amino hippurate kinetics.
The influence of probenecid on p-amino hippurate (PAH) kinetics was investigated in rat. Probenecid was administered i.p. (25, 50, 100, 150 and 200 mg/kg) two hours before PAH administration (25 mg/kg i.v.). The distribution and the rate of elimination of PAH was influenced by probenecid co-administration: the distribution decreased after probenecid doses higher than 150 mg/kg and the rate of elimination decreased after doses higher than 50 mg/kg.
Giorgi
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Instituto di Farmacologia, Università di Siena, Italy.
Urso
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Segre
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D000818:Animals; D005260:Female; D007275:Injections, Intravenous; D011339:Probenecid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D010130:p-Aminohippuric Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D011339:Probenecid; D010130:p-Aminohippuric Acid