Regulations of male-dominant P-450Md mRNA in rat liver by hormonal factors and xenobiotics.
Male-dominant P-450Md mRNA was undetectable in the livers of newborn rats. In female rat livers, the mRNA appeared at 17 days of age and then decreased to very low levels in the adult periods. The level of P-450Md mRNA in female rats was increased by phenobarbital or dexamethasone treatment, whereas the level in the males was depressed by methylcholanthrene. Hypophysectomy decreased the level of P-450Md mRNA in male rat livers, and continuous infusion or twice-daily injections of growth hormone to hypophysectomized rats caused further suppression or clear restoration, respectively, of the mRNA level.
Nagata
K
K
Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan.
Shimada
M
M
Yamazoe
Y
Y
Kato
R
R
D000818:Animals; D001483:Base Sequence; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant / Q000235:genetics*; D006728:Hormones / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D015262:Xenobiotics / Q000494:pharmacology*
D006728:Hormones; D012333:RNA, Messenger; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System