Hemangioblastomas: clinical characteristics, surgical results and immunohistochemical studies.
A surgical series of 59 patients with cerebellar or spinal cord hemangioblastomas or von Hippel-Lindau's (VHL) syndrome is analyzed. The presence of the tumor is easily detected by Computerized Tomography (CT) and Nuclear Magnetic Resonance (NMR), but angiography is still necessary for a correct surgical planning. The value of a sharp distinction among patients with single hemangioblastomas and the ones with Lindau's disease and VHL syndrome is stressed. In fact patients with single cerebellar or spinal hemangioblastomas have a good prognosis, while patients with disseminated hemangioblastomas have a rather poor outlook. Neuropathological studies with immunohistochemical techniques have been performed to identify the nature of the stromal cells of the hemangioblastomas: their origin from glial, endothelial and monociticphagocitic elements seems excluded.
Lodrini
S
S
Department of Neurosurgery, Istituto Nazionale Neurologico, C. Besta, Milano, Italy.
Lasio
G
G
Cimino
C
C
Pluchino
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D002528:Cerebellar Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006394:Hemangiosarcoma / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis; D012189:Retrospective Studies; D013120:Spinal Cord Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D014746:Vimentin / Q000032:analysis; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis; D006623:von Hippel-Lindau Disease / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D014841:von Willebrand Factor / Q000032:analysis
D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D014841:von Willebrand Factor; D009113:Muramidase