Pharmacokinetics of piroxicam in rats.
Pharmacokinetic of piroxicam was studied in the rat. Plasma and blood samples were analyzed by an high-performance liquid chromatography assay method. Plasma protein binding and blood to plasma concentration ratio were determined. Pharmacokinetic analysis was carried out fitting exponential equation to experimental data. All calculations were made using both JANA and PCNONLIN programs. This study reports a good estimation of the pharmacokinetic parameters of piroxicam in rats.
Fernandez-Troconiz
J I
JI
Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Navarra, Pamplona, Spain.
Lopez-Bustamante
L G
LG
Fos
D
D
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D010894:Piroxicam / Q000493:pharmacokinetics*; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet
D001798:Blood Proteins; D010894:Piroxicam