Stimulation of endothelial cell migration by thrombin.
The blood proteinase thrombin was shown to stimulate the migration of porcine aortic endothelial cells in vitro. This effect seems to be dependent on the receptor binding of thrombin to the target cell. Prostaglandins could mediate endothelial cell migration by acting as "second messengers".
Pankonin
G
G
Ernst-Moritz-Arndt University, Department of Pharmacy, Greifswald, FRG.
Teuscher
E
E
D000818:Animals; D001011:Aorta; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D004151:Dipeptides / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D013552:Swine; D013917:Thrombin / Q000494:pharmacology*
D004151:Dipeptides; D010880:Piperidines; C038708:N(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide; D013917:Thrombin; D007213:Indomethacin