[In situ production and possible role of interleukins in clinical immunopathology].
We used in situ hybridization to study the expression of interleukin genes in sarcoidosis and in persistent generalized lymphadenopathy of HIV disease. In both cases, we found a dramatic over-expression of the interferon-gamma (IFN gamma) gene as compared to that of the interleukin-2 (IL-2) gene. In sarcoidosis, IFN gamma producing cells are CD4 T cells and are associated with IL-1 beta gene expressing monocytic cells. In HIV lymphadenopathy IFN gamma producing cells are C8 T cells engaged in cytotoxic function, as evidenced by the concomitant expression of serine esterase B gene. Thus distinct patterns of interleukin production can be defined in vivo in selected immunopathological situations.
Galanaud
P
P
Unité d'Immunopathologie et Immunologie virale de l'INSERM, INSERM U 131, Clamart.
Devergne
O
O
Crevon
M C
MC
Emilie
D
D
D015658:HIV Infections / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007378:Interleukins / Q000235:genetics / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D008206:Lymphatic Diseases / Q000235:genetics / Q000276:immunology; D009693:Nucleic Acid Hybridization; D012507:Sarcoidosis / Q000235:genetics / Q000276:immunology*
D007378:Interleukins
Production in situ et rôle possible des interleukines en immunopathologie clinique.