Metalloendopeptidase activity in urine of rodents.
The brush border membrane of mice and rats contains a phosphoramidon-insensitive metalloproteinase, meprin (neutral endopeptidase-2; NEP-2). The role of meprin is unknown, but we have shown that urine from these species contains insulin B chain degrading activity that is due to a phosphoramidon-insensitive metalloendopeptidase. By enzymic and immunological criteria, it is likely that this activity is due to meprin, and introduces the possibility that this enzyme may have a role in urinary function.
Beynon
R J
RJ
Department of Biochemistry, University of Liverpool.
Flannery
A V
AV
Macadam
G C
GC
D000818:Animals; D007668:Kidney / Q000201:enzymology; D008666:Metalloendopeptidases / Q000652:urine*; D051379:Mice; D008871:Microvilli / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D008666:Metalloendopeptidases