title: [The structure and absolute configuration of isorupestonic acid from Artemisia rupestris L].
abstract: A new sesquiterpene compound named isorupestonic acid was isolated from Artemisia rupestris and its absolute stereostructure was elucidated as 3B by spectral and X-ray crystallographic methods. Interestingly, the isorupestonic acid is based upon an unusual 6, 7 membered ring skeleton differing from the 5, 7 membered ring rupestonic acid although both have the same absolute configuration at C-1. The biogenesis of isorupestonic acid most likely involves breaking the C4-C5 bond of rupestonic skeleton and forming the C5-C14 bond. The absolute configuration of rupestonic acid was also determined as 4C by X-ray analysis and CD data.
authors.affiliation: Xinjiang Institute of Materia Medica, Urumuqi.
authors.forename: G S
authors.initials: GS
authors.lastname: Xu
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.forename: D
authors.initials: D
authors.lastname: Wu
authors.forename: D Q
authors.initials: DQ
authors.lastname: Yu
authors.forename: C H
authors.initials: CH
authors.lastname: He
authors.forename: J J
authors.initials: JJ
authors.lastname: Yang
authors.forename: F
authors.initials: F
authors.lastname: Sun
mesh_terms: D052176:Azulenes; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D052176:Azulenes; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C057488:rupestonic acid; C073949:isorupestonic acid