Effect of dietary fish oil on platelet aggregability: comparison between two oils with different eicosapentaenoic to arachidonic acid ratio.
Rats, acclimatized on a control diet, were fed for 60 days with diets, supplemented with 10% fat of either marine Hilsa fish (Hilsa ilisa) or fresh-water Chital fish (Notopterus chitala). The percentage of eicosapentaenoic acid in chital oil diet was 0.57 times that of the hilsa oil diet, but the eicosapentaenoic to arachidonic acid ratio in the latter (4.08) was 3.2 times that of the former (1.27). Otherwise these two diets were comparable in respect to total saturated, monounsaturated and n-3 polyunsaturated fatty acid contents. Results showed that of the two only hilsa oil diet could significantly lower platelet aggregability and in vitro thromboxane production, through replacement of arachidonic acid in platelet phospholipid by eicosapentaenoic acid. The antithrombic criteria of the oil seems to be a combination of low arachidonic acid content and high eicosapentaenoic to arachidonic acid ratio.
Bandyopadhyay
I
I
Department of Chemistry, Bose Institute, Calcutta, India.
Saha
S
S
Dutta
J
J
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D001792:Blood Platelets / Q000737:chemistry / Q000187:drug effects; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis; D005343:Fibrinolytic Agents / Q000494:pharmacology; D005395:Fish Oils / Q000737:chemistry / Q000494:pharmacology*; D010743:Phospholipids / Q000032:analysis; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D013928:Thromboxane A2 / Q000096:biosynthesis
D001095:Arachidonic Acids; D005227:Fatty Acids; D005343:Fibrinolytic Agents; D005395:Fish Oils; D010743:Phospholipids; D010975:Platelet Aggregation Inhibitors; D013928:Thromboxane A2; D015118:Eicosapentaenoic Acid