Determination of the metabolites of terfenadine in human urine by thermospray liquid chromatography-mass spectrometry.
Thermospray liquid chromatography-mass spectrometry (TSP LC-MS) was used to determine human urinary metabolites of terfenadine after oral administration of terfenadine tablets. In addition to the two previously identified major metabolites, azacyclonol (MDL 4829) and the 'acid' metabolite (MDL 16,455), three additional metabolites were also detected. One of the additional metabolites was identified as the 'alcohol' metabolite (MDL 17,523) and the other two were proposed to be an 'aldehyde' and a 'ketone-acid' metabolites from their TSP mass spectra. The results of this study demonstrated that TSP LC-MS is a useful technique for the study of terfenadine biotransformation.
Chen
T M
TM
Marion Merrell Dow Research Institute, Cincinnati, OH 45215-6300.
Chan
K Y
KY
Coutant
J E
JE
Okerholm
R A
RA
D002853:Chromatography, Liquid; D006801:Humans; D013058:Mass Spectrometry; D015394:Molecular Structure; D016593:Terfenadine / Q000652:urine*
D016593:Terfenadine