Genomic imprinting: developmental significance and molecular mechanism.
Imprinting results in the preferential expression of either the maternal or the paternal allele of certain genes, and has a critical influence on the regulation of mammalian development. The identification of specific imprinted chromosomal regions and genes is being used to unravel the molecular mechanism of imprinting and the developmental significance of the non-random expression of parental alleles.
Surani
M A
MA
Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.
D000818:Animals; D002678:Chimera; D002875:Chromosomes; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D005796:Genes; D008297:Male; D008957:Models, Genetic; D009024:Morphogenesis / Q000235:genetics; D010290:Parents; D010641:Phenotype