[Biological indicators of the renal involvement in workers with previous exposure to cadmium: a 5-year follow up].
Six welders who had been exposed to high cadmium concentrations were monitored for 5 years after cessation of exposure. Indicators of exposure and effect had shown marked alterations during exposure, with 3 subjects showing low molecular weight proteinuria (beta 2-microglobinuria), one of whom with total proteinuria as well. During the follow-up period, beta 2-microglobinuria increased up to a maximum in 2 subjects; in another subject, after a temporary increase, beta 2-microglobinuria returned to normal levels after 5 years. Urinary enzyme excretion had exceeded normal values during exposure; during the follow-up, brush border enzyme excretion was persistently high (only angiotensin converting enzyme activity showed a progressive reduction), whereas cytoplasmatic enzyme values returned to normal one year after cessation of exposure.
Trevisan
A
A
Istituto di Medicina del Lavoro, Università di Padova.
Maso
S
S
D000328:Adult; D002104:Cadmium / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D004796:Clinical Enzyme Tests; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011507:Proteinuria / Q000139:chemically induced / Q000175:diagnosis; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D014896:Welding; D001613:beta 2-Microglobulin / Q000652:urine
D001613:beta 2-Microglobulin; D002104:Cadmium
Indicatori biologici di effetto renale in lavoratori con pregressa esposizione a cadmio: follow-up di cinque anni.