[The effect of vaccination on local immunity indices; the determination of antimeningococcal antibodies in saliva].
Local immunity characteristics were studied in 130 young males; of these, 80 had been immunized with group A meningococcal vaccine. In nonstimulated saliva, collected prior to vaccination, then on days 7, 14 and 30 after vaccination, the levels of IgA antibodies to group A meningococcal group-specific polysaccharide (PS-A) were determined in the enzyme immunoassay, and secretory IgA and IgA, IgG, IgM were determined by Mancini's method. The study revealed that after the parenteral administration of group A meningococcal vaccine an increase in the concentrations of SIgA and IgA antibodies to PS-A occurred. The manifestation of changes in local immunity characteristics in response to meningococcal vaccine depended on the initial level of IgA antibodies to PS-A.
Martynov
Iu V
IuV
Marinin
I Iu
IIu
Deviatkina
N N
NN
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000032:analysis*; D001428:Bacterial Vaccines / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D009345:Neisseria meningitidis / Q000276:immunology*; D012463:Saliva / Q000276:immunology*; D013997:Time Factors
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Vliianie vaktsinatsii na pokazateli mestnogo immuniteta; opredelenie protivomeningokokkovykh antitel v sliune.