title: Hepatitis B surface and e antigen seropositivity in mothers and cord blood at Port Moresby General Hospital: implications for a control program.
abstract: Analysis of 100 unselected paired maternal and cord blood samples showed 11 mothers to be HBsAg positive and 6 of these to be also HBeAg positive. 5 cord blood samples were HBsAg positive and 3 were HBeAg positive. Assuming a protective efficacy rate of 75%, the present plasma-derived hepatitis B virus vaccine control program is likely to prevent the perinatal acquisition of the hepatitis B virus carrier state in 27 per 1000 children. The addition of immunoglobulin prophylaxis would be likely to reduce this by another 5 per 1000, but its use does not appear practicable at the present time.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Papua New Guinea.
authors.forename: M
authors.initials: M
authors.lastname: Sapuri
authors.forename: D M
authors.initials: DM
authors.lastname: Babona
authors.forename: C A
authors.initials: CA
authors.lastname: Klufio
authors.forename: J D
authors.initials: JD
authors.lastname: Vince
mesh_terms: D000328:Adult; D002353:Carrier State / Q000453:epidemiology / Q000276:immunology; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006513:Hepatitis B e Antigens / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D010219:Papua New Guinea / Q000453:epidemiology; D016036:Seroepidemiologic Studies
chemical_list: D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens