Effect of thyrotropin-releasing hormone on vestibular habituation in guinea pigs.
An experiment was carried out to examine the effects of TRH on the acquisition of vestibular habituation in guinea pigs. Vestibular habituation was obtained in approximately 12 days by vestibular training of unidirectional velocity steps imposed 30 times daily for 15 days, and was retained for more than 2 weeks even though the daily vestibular training was ceased. When compared with the time to attain the maximum level of the vestibular habituation depicted through decrement of postrotatory nystagmus between control and thyrotropin-releasing hormone (TRH) injection groups, the TRH injection group took significantly longer than the control group. Thus the results have shown that the systemic administration of TRH could result in the retardation of the acquisition of vestibular habituation. This could be due to the depressant action of TRH on the cerebellar neurons.
Ishikawa
K
K
Department of Otorhinolaryngology, Akita University School of Medicine, Japan.
Yamada
M
M
D000818:Animals; D004584:Electronystagmography; D006168:Guinea Pigs; D009760:Nystagmus, Physiologic / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D013973:Thyrotropin-Releasing Hormone