Increased plasma t-PA activity and urinary PGE2 after repeated oral administration of defibrotide to the rat and the mouse.
Nunziata
A
A
Research Toxicology Centre S.p.A., Pomezia, Italy.
Mariani
M F
MF
Cascone
M
M
Calvani
A B
AB
Pescador
R
R
D000284:Administration, Oral; D000818:Animals; D015232:Dinoprostone / Q000652:urine*; D004334:Drug Administration Schedule; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D051379:Mice; D011089:Polydeoxyribonucleotides / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D010959:Tissue Plasminogen Activator / Q000097:blood* / Q000187:drug effects
D005343:Fibrinolytic Agents; D011089:Polydeoxyribonucleotides; C036901:defibrotide; D010959:Tissue Plasminogen Activator; D015232:Dinoprostone