title: [Separation of epimers of anisodamine (654-2) with HPLC using chiral additives in the mobile phase].
abstract: The separation of epimers of anisodamine were studied with HPLC using a reversed phase ODS C18 column. Several chiral additives were tried in the mobile phases. d-Camphorsulfonic acid and L-(+)-dibutyl tartrate showed good resolution ability for the separation of the isomers, a pair of epimers of anisodamine were well separated; while beta-cyclodextrin appeared to have no selectivity for the epimers.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
authors.forename: L
authors.initials: L
authors.lastname: Xie
authors.forename: H
authors.initials: H
authors.lastname: Chi
authors.forename: T H
authors.initials: TH
authors.lastname: Zhou
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D012991:Solanaceous Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D012991:Solanaceous Alkaloids; C003922:anisodamine