title: The incidence and beta-lactam resistance of Proteus vulgaris in hospital infections: the last decade.
abstract: During the period of 1980-1990, 581 Proteus vulgaris strains were obtained in a general hospital. They were considered as the significant isolate in 0.6% of soft tissue infections, 0.6% of urinary tract infections and in 0.2% of bacteremic episodes. Sixty-three percent of the 393 tested strains showed resistance to ampicillin, cefazolin and cefamandole or cefuroxime. About 7% were susceptible to all beta-lactam drugs, and showed a very low beta-lactamase activity and 5% of the strains showed a phenotype of resistance including ampicillin, carbenicillin-ticarcillin, cefazolin and cefamandole or cefuroxime, and presented increased chromosomal beta-lactamase activity. Cefotaxime-resistance was detected in 2% of the isolates which appeared in the period 1987-1990.
authors.affiliation: Servicio de Microbiología, Hospital Ramón y Cajal, Instituto Nacional de la Salud, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gomez-Alferez
authors.forename: F
authors.initials: F
authors.lastname: Baquero
authors.forename: R
authors.initials: R
authors.lastname: Canton
authors.forename: E
authors.initials: E
authors.lastname: Loza
authors.forename: J
authors.initials: J
authors.lastname: Martinez-Beltran
mesh_terms: D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam / Q000494:pharmacology; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology*; D002511:Cephalosporins / Q000494:pharmacology; D003428:Cross Infection / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009070:Moxalactam / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D010641:Phenotype; D011512:Proteus Infections / Q000453:epidemiology / Q000382:microbiology*; D011514:Proteus vulgaris / Q000187:drug effects* / Q000302:isolation & purification; D013030:Spain / Q000453:epidemiology; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000382:microbiology*; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D001618:beta-Lactamases; D001398:Aztreonam; D009070:Moxalactam