title: Effect of intrahippocampal quinolinic acid infusion on the amygdala kindling in rat.
abstract: The effect of intrahippocampal infusion of quinolinic acid (Quin), an endogenous excitatory amino acid, was studied on the amygdala kindling. Quin 120 nmol injected intrahippocampally 2 wk prior to the beginning of amygdala kindling significantly not only produced dorsal hippocampal pyramidal and granule cell loss but also decreased the number of stimuli to trigger the stage 5 seizures of amygdala kindling. In kindled rats, intrahippocampal 20 nmol Quin infusion fully inhibited the stage 5 of amygdala-kindled seizures. The inhibitory effect of Quin was antagonized by dl-2-amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate (NMDA) type receptors. The results suggest that NMDA-type receptors in the hippocampus may play a role in the control of the seizure threshold in the amygdala.
authors.affiliation: Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing.
authors.forename: H X
authors.initials: HX
authors.lastname: Ping
authors.forename: G Q
authors.initials: GQ
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Xie
authors.forename: H Q
authors.initials: HQ
authors.lastname: Wu
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000494:pharmacology; D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D007275:Injections, Intravenous; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects; D011805:Quinolinic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000596:Amino Acids; D000927:Anticonvulsants; D011805:Quinolinic Acids; D015763:2-Amino-5-phosphonovalerate; C031231:2-amino-7-phosphonoheptanoic acid