Suppression of kindled seizure following intraamygdaloid injection of pertussis toxin in rats.
To examine the role of GTP-binding proteins in amygdaloid (AM) kindling, pertussis toxin (PTX), which inhibits PTX-sensitive GTP-binding proteins through ADP-ribosylation, was injected into the stimulated AM of fully kindled rats. Intra-AM injections of PTX strongly suppressed kindled seizures. The significant seizure suppression began 2 days after the injection, lasted 4 days, and was due to an increase in afterdischarge threshold. The results suggest that PTX-sensitive GTP-binding proteins in the stimulated site play a significant role in the induction of kindled seizures.
Watanabe
Y
Y
Department of Neuropsychiatry, Fukushima Medical College, Japan.
Mori
N
N
Uemura
S
S
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D000679:Amygdala / Q000187:drug effects / Q000503:physiopathology*; D000818:Animals; D004558:Electric Stimulation; D019204:GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology*; D008297:Male; D037342:Pertussis Toxin; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D015290:Second Messenger Systems / Q000187:drug effects*; D012640:Seizures / Q000503:physiopathology*; D010566:Virulence Factors, Bordetella / Q000494:pharmacology*
D010566:Virulence Factors, Bordetella; D000246:Adenosine Diphosphate Ribose; D037342:Pertussis Toxin; D019204:GTP-Binding Proteins