title: Isolation of a new antitumor substance from Bacillus stearothermophilus.
abstract: A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-D1 (IC50: 4 micrograms/ml) and mouse mastocytoma, P-815 (IC50: 0.6 microgram/ml), but not that of Balb/c 3T3.
authors.affiliation: Faculty of Pharmaceutical Sciences, Osaka University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kohama
authors.forename: T
authors.initials: T
authors.lastname: Teramoto
authors.forename: K
authors.initials: K
authors.lastname: Iida
authors.forename: N
authors.initials: N
authors.lastname: Murayama
authors.forename: T
authors.initials: T
authors.lastname: Semba
authors.forename: N
authors.initials: N
authors.lastname: Tatebatake
authors.forename: Y
authors.initials: Y
authors.lastname: Kayamori
authors.forename: K
authors.initials: K
authors.lastname: Tsujikawa
authors.forename: T
authors.initials: T
authors.lastname: Mimura
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D001411:Geobacillus stearothermophilus / Q000737:chemistry*; D051379:Mice
chemical_list: D000970:Antineoplastic Agents