title: Effect of a dentifrice containing triclosan and a copolymer on plaque formation and gingivitis.
abstract: A total of one hundred twenty-one (121) adult male and female subjects completed a 6-month, double-blind clinical study comparing the effect on supragingival plaque formation and gingivitis of a dentifrice containing 0.3% Triclosan and 2.0% of a copolymer of methoxyethylene and maleic acid to a placebo dentifrice. Both the Triclosan/copolymer and placebo dentifrices contained 0.243% sodium fluoride in a silica base. Subjects were stratified into two balanced groups according to baseline plaque and gingivitis scores. They then received an oral prophylaxis and were assigned to use either the Triclosan/copolymer dentrifrice or the placebo dentifrice for the next 6 months. Subjects were evaluated for supragingival plaque formation and gingivitis after 3 and 6 months' use of the dentifrices. After 6 months, the Triclosan/copolymer dentifrice was shown to provide a 32.32% statistically significant reduction (99% level of confidence) in supragingival plaque formation, as compared to the placebo dentifrice. Also, after 6 months, the Triclosan/copolymer dentifrice was shown to provide a 25.64% statistically significant reduction (99% level of confidence) in gingivitis, as compared to the placebo dentifrice. It thus can be concluded from this clinical study that the twice daily use of the dentifrice containing 0.3% Triclosan and 2.0% of a copolymer in a 0.243% sodium fluoride/silica base provides statistically significant reductions in both supragingival plaque formation and gingivitis.
authors.affiliation: University of Medicine and Dentistry of New Jersey, Newark.
authors.forename: M J
authors.initials: MJ
authors.lastname: Deasy
authors.forename: S M
authors.initials: SM
authors.lastname: Singh
authors.forename: K N
authors.initials: KN
authors.lastname: Rustogi
authors.forename: D M
authors.initials: DM
authors.lastname: Petrone
authors.forename: G
authors.initials: G
authors.lastname: Battista
authors.forename: M E
authors.initials: ME
authors.lastname: Petrone
authors.forename: A R
authors.initials: AR
authors.lastname: Volpe
mesh_terms: D000328:Adult; D000368:Aged; D003773:Dental Plaque / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008298:Maleates / Q000627:therapeutic use*; D008875:Middle Aged; D010512:Periodontal Index; D011145:Polyvinyls / Q000627:therapeutic use*; D014260:Triclosan / Q000627:therapeutic use*
chemical_list: D003802:Dentifrices; D008298:Maleates; D011145:Polyvinyls; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D014260:Triclosan