The influence of the age of donors and recipients on the regional graft-versus-host reaction in mice.
Regional graft versus host (GVH) reaction in mice induced by injection of parental strain spleen cells into the footpad of F1, recipients, was measured 7 days later by a popliteal lymph node (PLN) enlargement index. Young, 6-week-old F1 hosts can be used for studying the age- and sex-dependent GVH reactivity of parental strain donors. On the other hand, senescent, 21-24-month-old F1 recipients are able to mount a host versus graft response against parental antigens which may obscure the typical GVH reaction. The PLN enlargement in syngeneic old F1 mice points to an autoimmune mechanism of this phenomenon.
Skowron-Cendrzak
A
A
Department of Immunobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Kubera
M
M
Bubak-Satora
M
M
Godowicz
W
W
D000375:Aging / Q000276:immunology*; D000818:Animals; D015551:Autoimmunity; D005260:Female; D006087:Graft vs Host Reaction / Q000276:immunology*; D008198:Lymph Nodes / Q000033:anatomy & histology / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009929:Organ Size; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000637:transplantation; D014185:Transplantation, Isogeneic