[The effect of nifedipine on pulmonary hemodynamics after injection of oleic acid in rabbits].
Twelve rabbits were divided into two groups, A: control group; B: nifedipine group. Oleic acid (0.1 ml/kg) was injected into pulmonary arteries of 12 rabbits. Nifedipine (1 mg/kg) was given sublingually before oleic acid injected in B group. The results showed that the pulmonary vascular resistance (PVR), pulmonary artery pressure (PAP) were obviously increased and cardiac output (CO) heart rate (HR) decreased in two groups (P less than 0.05, P less than 0.01, P less than 0.001). The degree of increase of PVR, and the degree of decrease of CO were obviously less in B group than that of A group (P less than 0.05, P less than 0.01, P less than 0.001 in different periods). The results showed that nifedipine improved pulmonary hemodynamics of pulmonary damage by oleic acid.
Tang
J F
JF
Cor Pulmonale Research Laboratory, Wenzhou Medical College, Zhejiang.
D000818:Animals; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D009829:Oleic Acids; D011652:Pulmonary Circulation / Q000187:drug effects*; D011817:Rabbits; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000503:physiopathology
D009829:Oleic Acids; D009543:Nifedipine