DNA synthesis in monkey kidney cellular culture, hematoporphyrin sensitized and He--Ne laser irradiated.
He--Ne laser irradiation for 1-45 J/cm2 has four actions upon monkey kidney cell cultures: a) a stimulation of nuclear DNA synthesis after 20 J/cm2; b) a diminution of replication after higher dose (45 J/cm2); c) inhibition of nuclear DNA synthesis and d) a marked cytotoxic effect. At lower radiation fluences (1-5 J/cm2) the influence on the biosynthesis of DNA is not significant.
Dima
V F
VF
Cantacuzino Institute, Bucharest, Romania.
Murg
B
B
Vasiliu
V
V
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D002522:Chlorocebus aethiops; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006415:Hematoporphyrins / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D007834:Lasers; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D006415:Hematoporphyrins; D014316:Tritium; D004247:DNA; D013936:Thymidine