Synthesis and anti-peptic activity of compounds related to the metabolites of sodium 3-ethyl-7-isopropyl-1-azulenesulfonate (KT1-32).
The metabolites of sodium 3-ethyl-7-isopropyl-1-azulenesulfonate (KT1-32, 1), a candidate as an anti-ulcer drug, and related compounds were synthesized. The effects of the compounds on anti-peptic activity were determined as compared to that of 1.
Yanagisawa
T
T
Kotobuki Seiyaku Co., Ltd., Nagano, Japan.
Kosakai
K
K
Izawa
C
C
Tomiyama
T
T
Yasunami
M
M
D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D052176:Azulenes; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D052176:Azulenes; D012717:Sesquiterpenes; C061956:azuletil