title: [Morphological evidence of the possible role of cytochrome P-450 in the development of an autoimmune process in the liver].
abstract: Morphological alterations in rat's liver during lipid peroxidation induction by paraqat were studied. Infiltration of liver by lymphocytes, macrophages and plasma cells was studied. On ultrastructure level profound extension of rough reticulum cistern and destruction of mitochondrial cristae were revealed by immunohistochemical methods. Cytochrom P-450 was localized on the fibrin fibers.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Gladyshev
authors.forename: S I
authors.initials: SI
authors.lastname: Kolesnikov
authors.forename: A V
authors.initials: AV
authors.lastname: Semeniuk
authors.forename: A V
authors.initials: AV
authors.lastname: Sviridov
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure*; D008107:Liver Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D010269:Paraquat; D051381:Rats
chemical_list: D003577:Cytochrome P-450 Enzyme System; D010269:Paraquat
vernacular_title: Morfologicheskie svidetel'stva vozmozhnoĭ roli tsitokhroma P-450 v razvitii autoimmunnogo protsessa v pecheni.