Ketoconazole hepatotoxicity in a patient treated for environmental illness and systemic candidiasis.
Environmental illness, a hypothesized disease caused by exposure to substances such as combustion products, pesticides, food additives, and Candida albicans, is discussed. The case of a patient with environmental illness and systemic candidiasis for six weeks with ketoconazole, liver enzyme concentrations increased. One month after discontinuation of ketoconazole, the liver enzyme concentrations decreased; however, over the next five months, liver enzymes and bilirubin increased. The patient developed encephalopathy and eventually was transferred to a medical center for possible liver transplant. A review of the literature pertaining to ketoconazole hepatotoxicity is also presented.
Brusko
C S
CS
Purdue University School of Pharmacy and Pharmacal Sciences, Lafayette, IN.
Marten
J T
JT
D000328:Adult; D002177:Candidiasis / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology; D004781:Environmental Exposure / Q000009:adverse effects; D004785:Environmental Pollutants / Q000506:poisoning*; D005260:Female; D006801:Humans; D007565:Jaundice / Q000139:chemically induced / Q000201:enzymology; D007654:Ketoconazole / Q000009:adverse effects* / Q000627:therapeutic use; D008107:Liver Diseases / Q000201:enzymology; D008297:Male; D008875:Middle Aged
D004785:Environmental Pollutants; D007654:Ketoconazole