Influence of hypersulfated lactobionic acid amides on tissue plasminogen activator release.
Under our experimental conditions, the sulfated bis-lactobionic acid amide, LW 10079, showed the strongest t-PA-releasing effect in the isolated perfused pig ear. In rats the sulfated bis-lactobionic acid amide LW 10121 was the most potent compound in acute t-PA release. In both experiments the bis-lactobionic acid amide LW 10082 did not work as a releaser of t-PA. Therefore in the case of LW 10082, the activation of the fibrinolytic pathway as a possible mechanism of its antithrombotic effect can be excluded.
Klöcking
H P
HP
Institute of Pharmacology and Toxicology, Medical Academy Erfurt, Germany.
Hoffmann
A
A
Fareed
J
J
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D004187:Disaccharides / Q000737:chemistry / Q000494:pharmacology*; D004423:Ear / Q000098:blood supply; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D010477:Perfusion; D015849:Plasminogen Inactivators / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000494:pharmacology*; D013552:Swine; D010959:Tissue Plasminogen Activator / Q000097:blood*
D000577:Amides; D004187:Disaccharides; D005343:Fibrinolytic Agents; D015849:Plasminogen Inactivators; D013431:Sulfates; C005608:lactobionic acid; D010959:Tissue Plasminogen Activator