Plasmid-mediated ROB-1 beta-lactamase in Pasteurella multocida from a human specimen.
A Pasteurella multocida human isolate was resistant to beta-lactams because of production of ROB-1 beta-lactamase. The beta-lactamase was encoded by a 4.3-kb plasmid closely related to that of a Pasteurella bovine strain, as shown by Sau3A restriction profile and hybridization with a plasmid probe containing the blaROB-1 gene.
Rosenau
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Laboratoire de Microbiologie, Groupe Hospitalier Boucicaut-Vaugirard, Paris, France.
Labigne
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Escande
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Courcoux
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Philippon
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002417:Cattle; D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial / Q000235:genetics; D006801:Humans; D009693:Nucleic Acid Hybridization; D010325:Pasteurella / Q000201:enzymology* / Q000235:genetics; D010326:Pasteurella Infections / Q000382:microbiology; D010957:Plasmids; D014169:Transformation, Bacterial; D001618:beta-Lactamases / Q000096:biosynthesis*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D047090:beta-Lactams; D001618:beta-Lactamases