Characterization of hepsin, a membrane bound protease.
Hepsin is a membrane bound protease of 51 kDa present in mammalian cells. It contains a stretch of hydrophobic sequence of 27 amino acid residues in its N-terminal region. By employing fluorescent immunostaining of cells and western blot analysis of the various cell subfractions, the catalytic subunit (carboxyl terminal half) of hepsin is found at the cell surface. The hepsin gene is expressed in most tissues of a young adult baboon, particularly in the liver at high levels.
Tsuji
A
A
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109.
Torres-Rosado
A
A
Arai
T
T
Chou
S H
SH
Kurachi
K
K
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000201:enzymology; D015870:Gene Expression; D006801:Humans; D008099:Liver / Q000201:enzymology; D010215:Papio; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism*; D014018:Tissue Distribution
D012697:Serine Endopeptidases; C055645:hepsin