Hepatobiliary elimination of bendamustin (Cytostasan) in rats.
Biliary excretion of bendamustin (Cytostasan, 5-[bis(2-chloroethyl)amino]-i-methylbenzimidazole-2-butyric acid; 1) and its metabolites was studied in rats after i.v. administration of 14C-1. The most significant finding was the rapid excretion of 1 related radioactivity in the bile occurring shortly after injection. While radioactivity eliminated by bile within 2 h was 41.8%, in the course of subsequent 22 h it amounted only to 3.2%. Bile samples analyzed by TLC indicated that the total amount of radioactivity was excreted in the form of conjugates and two hydroxy metabolites. A significant amount of radioactivity was excreted in urine. The diversion of bile by cannulation of the bile duct led to a significant decrease of elimination by feces.
Bezek
S
S
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, CSFR.
Scasnár
V
V
Trnovec
T
T
Grupe
R
R
D000818:Animals; D000069461:Bendamustine Hydrochloride; D001646:Bile / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D005243:Feces / Q000737:chemistry; D008099:Liver / Q000378:metabolism*; D008297:Male; D009588:Nitrogen Mustard Compounds / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D009588:Nitrogen Mustard Compounds; D000069461:Bendamustine Hydrochloride