title: Pharmacokinetics and pharmacodynamics of slow-release theophylline during treatment with nimesulide.
abstract: The pharmacodynamic and pharmacokinetic interactions were studied between nimesulide, a recently introduced non-steroidal anti-inflammatory drug, and theophylline, another highly protein-bound drug, in patients who were receiving slow-release theophylline for a chronic airflow-obstruction and who also needed anti-inflammatory treatment. A good tolerability was demonstrated of the two drugs association and there was an absence of pharmacodynamic interaction, as shown by lung function parameters, assayed before and after the coinciding nimesulide association. The pharmacokinetics of nimesulide and 4-hydroxy-nimesulide (its active metabolite) were not modified, in agreement with data shown by other authors. On the contrary, there was a slight alteration of theophylline pharmacokinetics, yet neither clinically nor biologically significant, probably due to an enzymatic induction.
authors.affiliation: Division of Clinical Immunology and Allergology, University of Siena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Auteri
authors.forename: P
authors.initials: P
authors.lastname: Blardi
authors.forename: F
authors.initials: F
authors.lastname: Bruni
authors.forename: L
authors.initials: L
authors.lastname: Domini
authors.forename: A L
authors.initials: AL
authors.lastname: Pasqui
authors.forename: M
authors.initials: M
authors.lastname: Saletti
authors.forename: M S
authors.initials: MS
authors.lastname: Verzuri
authors.forename: I
authors.initials: I
authors.lastname: Scaricabarozzi
authors.forename: G
authors.initials: G
authors.lastname: Vargui
authors.forename: T
authors.initials: T
authors.lastname: Di Perri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003692:Delayed-Action Preparations; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013449:Sulfonamides / Q000493:pharmacokinetics / Q000494:pharmacology*; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D003692:Delayed-Action Preparations; D013449:Sulfonamides; D013806:Theophylline; C012655:nimesulide