title: Four compartment mammillary model applied to the pharmacokinetics of a spiroarsorane administered orally to rabbits.
abstract: Rekik et al. dealt with the pharmacokinetics of two spiroarsoranes molecules administered intravenously or orally to rabbits. For the intravenous study they used an open two-compartment model. For the oral study they admitted that they were unable to fit the data to a model. In this paper the plasma concentration profile of molecule 2 after oral administration using a four mammillary open compartment model is described. This type of model (which requires a fourth degree equation) has been previously described. Here it is applied to a concrete situation.
authors.affiliation: UFR de Mathématiques, Université Paul Sabatier, Toulouse, France.
authors.forename: J
authors.initials: J
authors.lastname: de Biasi
authors.forename: L
authors.initials: L
authors.lastname: Rekik
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001147:Arsanilic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D001825:Body Fluid Compartments / Q000502:physiology*; D016018:Least-Squares Analysis; D008432:Mathematical Computing; D008954:Models, Biological; D011817:Rabbits; D013141:Spiro Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D013141:Spiro Compounds; C059856:octamethyl-2,2,3,3,7,7,8,8-arsa-5-(4-hydroxy)-3-acetamidophenyl-5-spiro-(4,4)-nonane; D001147:Arsanilic Acid