In vitro aggregation of macrophages around human-derived Pneumocystis carinii.
Interaction between human monocyte-derived macrophages with human Pneumocystis carinii was examined in this study. Macrophages formed aggregates around P. carinii in the presence of heat-inactivated, but not native serum. This interaction is distinct from phagocytosis and appears to be analogous to granuloma formation.
Blumenfeld
W
W
Department of Anatomic Pathology, Veterans Administration Medical Center, San Francisco, California.
McCook
O
O
Griffiss
J M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D002449:Cell Aggregation; D006801:Humans; D066298:In Vitro Techniques; D016676:Macrophages, Alveolar / Q000502:physiology*; D011010:Pneumocystis / Q000276:immunology*