[Temperature sensitive liposome encapsulated adriamycin combined with hepatic artery embolization].
A temperature sensitive liposome composed of a vesicle membrane of dipalmitoyl phosphatidylcholine and encapsulated adriamycin was made by the modified reverse-phase evaporation method. The encapsulation efficiency measured with a centrifugal filtration method was about 38%. The phase-transition temperature of the liposome determined by DSC was 41 degrees C. The liposome size was 851 +/- 50 nm, and the size distribution was from 772 to 952 nm as measured by laser particle analyzer with dynamic light scatter method. Eighty-four percent of the encapsulated drug could be released at precisely the phase-transition temperature of liposome in vitro. The results show that the liposomal drug is sensitive to temperature-controlled release.
Zou
Y Y
YY
Pharmaceutical Research Institute, Shenyang College of Pharmacy.
Gu
X Q
XQ
Horikoshi
I M
IM
D015060:1,2-Dipalmitoylphosphatidylcholine; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D004621:Embolization, Therapeutic; D006499:Hepatic Artery; D008081:Liposomes; D013696:Temperature
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008081:Liposomes; D015060:1,2-Dipalmitoylphosphatidylcholine; D004317:Doxorubicin