title: Squamous cell carcinoma antigen and protein-bound sialic acid in the management of head and neck cancer.
abstract: Serum squamous cell carcinoma antigen (SCCAg) and protein-bound sialic acid (PBSA) were measured in 43 head and neck cancer patients and 50 controls. SCCAg and PBSA were correlated with clinical stage, histological grade, presence/absence of keratin and disease course. Patients with advanced cancer (stage III and IV) and grade III tumors had higher PBSA levels but no such difference was observed for SCCAg. Head and neck cancer patients were grouped according to the disease status i.e. a) patients who developed recurrence and b) who responded to the adjuvant therapies. There was an excellent correlation between serial serum PBSA changes and the progression of disease or the response to therapy in patients with advanced head and neck cancer.
authors.affiliation: Division of Research, Gujarat Cancer Society, Ahmedabad, India.
authors.forename: J M
authors.initials: JM
authors.lastname: Bhatavdekar
authors.forename: D D
authors.initials: DD
authors.lastname: Patel
authors.forename: H H
authors.initials: HH
authors.lastname: Vora
authors.forename: D B
authors.initials: DB
authors.lastname: Balar
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D005069:Evaluation Studies as Topic; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D019158:N-Acetylneuraminic Acid; D009367:Neoplasm Staging; D011485:Protein Binding; D012680:Sensitivity and Specificity; D015843:Serpins; D012794:Sialic Acids / Q000097:blood*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015843:Serpins; D012794:Sialic Acids; C051072:squamous cell carcinoma-related antigen; D019158:N-Acetylneuraminic Acid