Clearance of plasmodium falciparum after reduced single daily doses of quinine in asymptomatic children in Guinea Bissau.
Asymptomatic schoolchildren in Guinea Bissau were given approximately 10 mg of quinine/kg body weight once daily during 5 days (n = 15) or 3 days (n = 16) for treatment of P. falciparum. Five children had parasitemia on the seventh day of follow up. Adverse reactions were reported by 12 children during treatment, mainly mild tinnitus, dizziness and vomiting. Single daily doses were less effective than the divided doses previously used by us for the same short time period and also associated with more frequent adverse events.
Bruchfeld
J
J
Department of Infectious Diseases, Roslagstull Hospital, Karolinska Institutet, Stockholm, Sweden.
Dias
F
F
Hellgren
U
U
Lebbad
M
M
Rombo
L
L
D000293:Adolescent; D002648:Child; D004244:Dizziness / Q000139:chemically induced; D004334:Drug Administration Schedule; D006169:Guinea-Bissau; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D010349:Patient Compliance; D011803:Quinine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014012:Tinnitus / Q000139:chemically induced; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced
D011803:Quinine