[Peroxides as plant constituents. 8. Guaianolide-peroxides from yarrow,Achillea millefolium L., a soluble component causing yarrow dermatitis].
From the ether extract of the blossoms of yarrow, Achillea millefolium L., two guaianolides (1, 2) with a peroxide bridged cyclopentane ring and an alpha-methylene-gamma-butyrolactone structure have been isolated. For these compounds the names alpha-peroxyachifolid (1) and beta-peroxyisoachifolid (2) are proposed. 1 is responsible for the allergic contact dermatitis caused by yarrow.
Rücker
G
G
Pharmazeutisches Institut der Universität, Bonn.
Manns
D
D
Breuer
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003877:Dermatitis, Contact / Q000209:etiology*; D007783:Lactones / Q000737:chemistry* / Q000633:toxicity; D010545:Peroxides; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000633:toxicity
D000900:Anti-Bacterial Agents; D000981:Antiprotozoal Agents; D007783:Lactones; D010545:Peroxides; D012717:Sesquiterpenes; C070257:alpha-peroxyachifolid
Guaianolid-Peroxide aus der Schafgarbe, Achillea millefolium L., Auslöser der Schafgarbendermatitis.