title: Experimental evidence of a potentiation by alpha,beta magnesium L-aspartate of the anxiolytic effect of diazepam. Four-plate test in mice and qEEG study in primates.
abstract: The anxiolytic dose 50 (AD50) of diazepam was determined in mice in the four-plate test and the EEG pattern elicited by diazepam was quantified by Fast Fourier Transformation in monkeys. The AD50 of diazepam was reduced by 2.7-fold after repeated treatment with alpha,beta magnesium L-aspartate. The increased EEG fast activity elicited by diazepam at the expense of slow activities was reinforced and more long lasting after alpha,beta magnesium L-aspartate treatment.
authors.affiliation: Institut de Recherche SIR international, Montrouge, France.
authors.forename: M G
authors.initials: MG
authors.lastname: Borzeix
authors.forename: J P
authors.initials: JP
authors.lastname: Akimjak
authors.forename: J M
authors.initials: JM
authors.lastname: Dupont
authors.forename: R
authors.initials: R
authors.lastname: Cahn
authors.forename: J
authors.initials: J
authors.lastname: Cahn
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced* / Q000188:drug therapy; D001224:Aspartic Acid / Q000494:pharmacology*; D003975:Diazepam / Q000009:adverse effects*; D004569:Electroencephalography; D008252:Macaca fascicularis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011581:Psychological Tests
chemical_list: D001224:Aspartic Acid; D003975:Diazepam