title: Fanconi's anemia: a clinico-hematological and cytogenetic study.
abstract: Eleven patients with typical features of Fanconi's anemia with cytogenetic studies were evaluated. Cytogenetic abnormalities was seen in all but one patient. Two patients had acute non-lymphoblastic leukemia (ANLL) and nine had Fanconi's anemia (FA). All patients with FA responded to oxymetholone and are well with a median follow up of 38.6 months. Both patients with ANLL died. This study stresses the need of an accurate cytogenetic analysis in FA patients along with a clinicohematological correlation.
authors.affiliation: Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay.
authors.forename: U H
authors.initials: UH
authors.lastname: Athale
authors.forename: S R
authors.initials: SR
authors.lastname: Rao
authors.forename: P R
authors.initials: PR
authors.lastname: Kadam
authors.forename: B
authors.initials: B
authors.lastname: Gladstone
authors.forename: C N
authors.initials: CN
authors.lastname: Nair
authors.forename: P A
authors.initials: PA
authors.lastname: Kurkure
authors.forename: S H
authors.initials: SH
authors.lastname: Advani
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics*; D005199:Fanconi Anemia / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006402:Hematologic Diseases / Q000150:complications / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008297:Male