title: Hemodynamic effects after partial exchange transfusion with pyridoxylated polyhemoglobin in chimpanzees.
abstract: Partial exchange transfusion with 8.5% pyridoxylated polyhemoglobin solution [PolyHb-PPa] was performed in five anesthetized spontaneously-breathing male chimpanzees weighing 22-30 kg. Mean exchange volume was 42.5 +/- 10.7 ml/kg BW (26.8-54.6 ml/kg), mean exchange rate 56.7 +/- 7.1% (48.2-67.4%). All animals survived long-term. The chimpanzee's hemodynamics remained stable for the 5 h observation period. Right and left ventricular filling pressures remained constant, mean arterial pressure and mean pulmonary arterial pressure increased by up to 40% after the exchange. Cardiac output remained unaffected by the partial exchange and stroke volume did not change substantially although oxygen capacity and oxygen transport capacity decreased by about a third. The failure of cardiac output to rise after partial exchange transfusion with PolyHb-PPa contrasts with results after isovolemic hemodilution using non-oxygen-carrying blood substitutes and is not adequately explained by the oxygen capacity of 8.5% PolyHb-PPa (9.3 ml O2/dl).
authors.affiliation: Department of Anesthesiology, University of Tübingen, FRG.
authors.forename: G
authors.initials: G
authors.lastname: Lenz
authors.forename: H
authors.initials: H
authors.lastname: Junger
authors.forename: R
authors.initials: R
authors.lastname: van den Ende
authors.forename: B
authors.initials: B
authors.lastname: Brotman
authors.forename: A M
authors.initials: AM
authors.lastname: Prince
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D005078:Exchange Transfusion, Whole Blood; D006439:Hemodynamics / Q000187:drug effects*; D006454:Hemoglobins / Q000494:pharmacology*; D008297:Male; D002679:Pan troglodytes; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D014661:Vasoconstriction
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; C030939:polyhemoglobin-pyridoxal-5-phosphate; D011732:Pyridoxal Phosphate