[Rat multiple organ failure model caused by zymosan injections: a pathomorphological study].
We succeeded in developing a Wistar rat multiple organ failure (MOF) model by intraperitoneal injection of Zymosan. 80 rats were divided into the experimental and control groups. On alternative days (1, 2, 4-5 day), rats were killed after their blood specimens were examined. In the experimental group, changes in PaO2, GPT and Cr were apparently significant as compared with those in the control group. Symptoms included lethargy, hyporeaction, and alimentary tract hemorrhage. By combining function with pathology changes at the cellular and subcellular level and histochemical aspects, we listed MOF pathological features for the diagnosis of DIC at its different stages.
Lu
J Y
JY
304th Hospital of People's Liberation Army, Beijing.
D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D008854:Microscopy, Electron; D009102:Multiple Organ Failure / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012015:Reference Standards; D015054:Zymosan
D015054:Zymosan