[Electrophysiologic study of the anti-arrhythmic mechanism of action of phosphocreatine in acute myocardial ischemia and reperfusion].
To determine the possible application of exogenous phosphocreatine (ePC) to protect the ischemic myocardium from reperfusion abnormalities in cardiac rhythm, the antiarrhythmic and antifibrillatory activities of the agent were studied in an acute myocardial ischemia model and reperfusion-induced cardiac damage. It was shown that ePC produced a pronounced antifibrillatory effect in acute coronary occlusion and subsequent reperfusion. The agent substantially increased the threshold of electric ventricular fibrillation and the frequency of spontaneous defibrillation. The highest activity was shown by ePC in ischemic myocardial reperfusion. The agent suppressed both rapid inward Na+ current and slow inward Ca2+ current. The effects of ePC on transmembrane ion currents suggest that the agent has a unique electrophysiological mechanism of action involving the properties of Classes I and IV antiarrhythmics, making ePC promising in clinical application in patients with impaired conduction and automatism.
Kryzhanovskiĭ
S A
SA
Kacharava
V G
VG
Marko
R
R
Kelemen
K
K
Kaverina
N V
NV
Sakhs
V A
VA
D000208:Acute Disease; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D002415:Cats; D003327:Coronary Disease / Q000150:complications* / Q000601:surgery; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D010725:Phosphocreatine / Q000494:pharmacology* / Q000627:therapeutic use
D010725:Phosphocreatine
Elektrofiziologicheskoe issledovanie mekhanizmov antiaritmicheskogo deĭstviia fosfokreatina pri ostroĭ ishemii i reperfuzii miokarda.