Neuronal activity and tonotopy in the auditory system visualized by c-fos gene expression.
Responsiveness in the cochlear nucleus complex and inferior colliculus of the mouse to tonal stimulation is labelled via immunocytochemically stained Fos protein that is expressed by c-fos gene activation in excited neurons. The locations of Fos-positive neurons closely reproduce the tonotopic maps in the dorsal cochlear nucleus and inferior colliculus. Thus, the c-fos method can demonstrate stimulus-related local neuronal activation on a single-cell level and may be useful to complement other mapping techniques such as electrophysiological recording or 2-deoxyglucose autoradiography.
Ehret
G
G
Abteilung Vergleichende Neurobiologie, Universität Ulm, F.R.G.
Fischer
R
R
D000161:Acoustic Stimulation; D000818:Animals; D001931:Brain Mapping; D003056:Cochlear Nerve / Q000166:cytology / Q000502:physiology; D003847:Deoxyglucose / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D016762:Genes, fos; D006309:Hearing / Q000502:physiology*; D007150:Immunohistochemistry; D007245:Inferior Colliculi / Q000166:cytology / Q000502:physiology; D051379:Mice; D009474:Neurons / Q000502:physiology*; D011247:Pregnancy; D015533:Transcriptional Activation
D003847:Deoxyglucose