Skeletal muscle ventricles: a promising treatment option for heart failure.
Our most recent work on cardiac assist with canine latissimus dorsi muscle in a skeletal muscle ventricle (SMV) configuration is reported here. One animal's SMV has been pumping blood effectively in the circulation for more than 16 months. To date there is no evidence of thromboembolism, and the dog has suffered no untoward effects. It has recently been shown, in a mock circulation study, that canine SMVs are capable of developing stroke work, at physiological preloads, much greater than that of the right ventricle and equivalent to that of the left ventricle. The improved ability of conditioned SMVs to perform work, independent of the circulation, during severe hypotension is also demonstrated. In the face of a 75% drop in left ventricular stroke work, the SMV stroke work dropped by only 50%. The continuing work on this subject suggests that a skeletal muscle ventricle may have the potential of becoming a viable alternative in the treatment of heart failure.
Pochettino
A
A
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine, Detroit, Michigan.
Anderson
D R
DR
Hammond
R L
RL
Spanta
A D
AD
Hohenhaus
E
E
Niinami
H
H
Huiping
L
L
Ruggiero
R
R
Hooper
T L
TL
Baars
M
M
D000818:Animals; D001243:Assisted Circulation; D001415:Back; D002304:Cardiac Pacing, Artificial / Q000379:methods; D004195:Disease Models, Animal; D004285:Dogs; D004558:Electric Stimulation / Q000379:methods; D006333:Heart Failure / Q000601:surgery*; D006439:Hemodynamics; D009132:Muscles / Q000502:physiology; D009200:Myocardial Contraction / Q000502:physiology; D013524:Surgical Flaps / Q000379:methods*