A simple tremor model induced by pentobarbitone in guinea pig.
We have recently reported that a combined application of chlorpromazine and pentobarbitone induced intermittently occurring tremor bursts in guinea pigs (Tan et al., in press). This was a chance discovery. It will be shown in the present work that chlorpromazine is not essential for this postural tremor; only pentobarbitone in low dosages produced intermittent tremor bursts in guinea pigs lying in a supine position. Chlorpromazine alone was not effective in producing tremor. The pentobarbitone-induced tremors were attenuated by the i.v. application of biperiden or lioresal. These results indicate that these tremors would be produced by the basal ganglia as in Parkinsonism.
Tan
U
U
Department of Physiology, Medical Faculty, Atatürk University, Erzurum, Turkey.
Gepdiremen
A
A
Kutlu
N
N
Cankaya
A
A
D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D001712:Biperiden / Q000494:pharmacology; D004576:Electromyography; D006168:Guinea Pigs; D010424:Pentobarbital; D014159:Transducers; D014202:Tremor / Q000139:chemically induced* / Q000503:physiopathology
D001712:Biperiden; D001418:Baclofen; D010424:Pentobarbital