Comparative and simultaneous effects of simvastatin and ciprofibrate on plasma lipid parameters and upon hepatic drug metabolizing and peroxisome proliferation marker enzymes in the male Wistar rat.
The effects of an associated treatment with Ciprofibrate and Simvastatin upon plasma lipid parameters, liver Mixed Function Oxidases enzymes and peroxisomal markers have been studied in male Wistar rats. The association was efficient upon triglycerides, but not upon cholesterol. The inducive and proliferative effects commonly exerted by Ciprofibrate (5 mg/kg/day) were not significantly modified by the simultaneous treatment with Simvastatin (10 mg/kg/day). The increase of the seric alanine amino transferase activity was however much more pronounced after the associated treatment than after single administration of Ciprofibrate or Simvastatin.
Charmoillaux
M
M
Formation de Biochimie Pharmacologique, Université de Bourgogne, Dijon, France.
Goudonnet
H
H
Mercenne
F
F
Mounié
J
J
Truchot
R C
RC
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D058607:Fibric Acids; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008830:Microbodies / Q000187:drug effects; D006899:Mixed Function Oxygenases / Q000187:drug effects; D051381:Rats; D019821:Simvastatin
D000924:Anticholesteremic Agents; D058607:Fibric Acids; D000960:Hypolipidemic Agents; D008055:Lipids; D002995:Clofibric Acid; D008148:Lovastatin; D019821:Simvastatin; D006899:Mixed Function Oxygenases; C019304:ciprofibrate