title: X-linkage and manic-depressive illness: a reassessment.
abstract: Genetic-epidemiological data and linkage studies with chromosomal markers are reviewed from the vantage point of X-linked inheritance. The results overall suggest that a gene predisposing to manic depression (bipolar affective illness) localized on the X-chromosome may exist in a subgroup of bipolar cases. However, in light of conflicting findings and methodological uncertainties in studying a disorder with unclear phenotype and complex inheritance, this issue is not yet closed. Additional research, including new linkage data and extension and re-evaluation of published data, is required to further our understanding of this intriguing hypothesis.
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York.
authors.forename: M
authors.initials: M
authors.lastname: Baron
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D012306:Risk; D012737:Sex Factors; D014960:X Chromosome
chemical_list: D005819:Genetic Markers