Improvement of dissolution and bioavailability for mebendazole, an agent for human echinococcosis, by preparing solid dispersion with polyethylene glycol.
The solid dispersion of mebendazole was prepared with polyethylene glycol (PEG) to enhance the dissolution rate of mebendazole, an agent for the chemotherapy of human echinococcosis. The dissolution rate of the solid dispersion increased compared with the physical mixture, and also increased with the incorporation of an increasing amount of PEG-6000. An extensive improvement of the dissolution rate was observed when the ratio of the solid dispersion of mebendazole to PEG-6000 was more than 1: 2. Furthermore, greater bioavailability in rabbits was obtained after oral administration of the solid dispersion compared with the physical mixture.
Chiba
Y
Y
Department of Pharmacy, Hokkaido University Hospital, School of Medicine, Hokkaido Univerisity, Sapporo, Japan.
Kohri
N
N
Iseki
K
K
Miyazaki
K
K
D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D008297:Male; D008463:Mebendazole / Q000737:chemistry* / Q000493:pharmacokinetics; D011092:Polyethylene Glycols; D011817:Rabbits; D012995:Solubility; D013535:Suspensions
D013535:Suspensions; D011092:Polyethylene Glycols; D008463:Mebendazole