Recent advances in our understanding of the biochemical interactions between platelet-activating factor and arachidonic acid.
In the last few years, it has become increasingly apparent that the biochemistry of PAF (platelet-activating factor) and that of arachidonic acid are interrelated in a number of inflammatory cells. Experiments presented here further point out that arachidonic acid plays a crucial role in the catabolism and biosynthesis of PAF. In addition, they suggest that the same phospholipid molecular species may serve as a source for both arachidonic acid and 1-alkyl-2-lyso-sn-glycero-3-phosphocholine during cell activation. Finally, they reveal that there may be common regulatory mechanisms for the biosynthesis of PAF and arachidonic acid metabolites. Taken together, studies examining the relationship between PAF and arachidonic acid suggest it may be difficult to consider the biochemistry of PAF without considering arachidonic acid metabolism and vice versa.
Chilton
F H
FH
Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224.
Cluzel
M
M
Triggiani
M
M
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D006801:Humans; D008407:Mast Cells / Q000378:metabolism; D008954:Models, Biological; D009504:Neutrophils / Q000378:metabolism; D010972:Platelet Activating Factor / Q000378:metabolism*
D001095:Arachidonic Acids; D010972:Platelet Activating Factor