title: [Central anticholinergic syndrome in intensive care patients].
abstract: Intensive care patients develop altered patterns of behaviour for a variety of reasons. However, the drug therapy instituted to ameliorate these psychoreactive problems may give rise to complications such as the central anticholinergic syndrome. Cholinergic receptors are scattered at random throughout the central nervous system. The depression of cholinergic transmission is not only secondary to the administration of drugs but is also due to abnormalities affecting other transmitter systems. To date, no definitive criteria have been established for the diagnosis of the central anticholinergic syndrome. The diagnosis is made by exclusion and by the administration of physostigmine either as an i.v. bolus of 0.03 mg/kg or as an infusion at the rate of 1-2 mg/h.
authors.affiliation: Krankenhaus Nordwest, Frankfurt/Main.
authors.forename: S
authors.initials: S
authors.lastname: Brede
authors.forename: R
authors.initials: R
authors.lastname: Dennhardt
mesh_terms: D001143:Arousal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D003422:Critical Care; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000008:administration & dosage / Q000009:adverse effects*; D010830:Physostigmine / Q000008:administration & dosage; D011605:Psychoses, Substance-Induced / Q000188:drug therapy / Q000209:etiology*; D011950:Receptors, Cholinergic / Q000187:drug effects; D011976:Receptors, Muscarinic / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000209:etiology*; D015300:Ventilator Weaning
chemical_list: D010276:Parasympatholytics; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D010830:Physostigmine
vernacular_title: Das zentrale anticholinerge Syndrom (ZAS) bei Intensivpatienten.