title: Human leukocyte antigens in relation to colonization by mutans streptococci in the oral cavity.
abstract: Mutans streptococci are well established as caries-inducing microorganisms in man. Most humans carry the bacteria, but in highly different numbers. This cannot be explained by environmental factors only. The aim of this study was to investigate a possible association between levels of colonization by mutans streptococci and the presence of certain B and DR human leukocyte antigens (HLA). Altogether, 170 subjects who had their HLA antigens determined (76 renal transplant patients and 94 healthy blood donors) were selected for the investigation. Paraffin-stimulated saliva samples were taken using the wooden spatula method with subsequent cultivation of mutans streptococci on mitis salivarius bacitracin agar plates. An association between the absence of HLA-DR 4 antigens and low, or undetectable, levels of mutans streptococci was found. This was statistically significant for the immunosuppressed renal transplant subjects. The same trend was observed among the healthy blood donors.
authors.affiliation: Department of Cariology, University of Lund, Malmö, Sweden.
authors.forename: M L
authors.initials: ML
authors.lastname: Wallengren
authors.forename: D
authors.initials: D
authors.lastname: Ericson
authors.forename: B
authors.initials: B
authors.lastname: Forsberg
authors.forename: U
authors.initials: U
authors.lastname: Johnson
mesh_terms: D000328:Adult; D015169:Colony Count, Microbial; D003731:Dental Caries / Q000276:immunology; D003733:Dental Caries Susceptibility; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D015235:HLA-B Antigens / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D015804:HLA-DR4 Antigen / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000382:microbiology; D013295:Streptococcus mutans / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen