Influence of food on the oral absorption and bioavailability of moricizine.
Moricizine, a unique Class I antiarrhythmic agent, was orally administered with and without a meal to 24 healthy male subjects to determine the effect of food on moricizine absorption and bioavailability. Relative to the fasting state, a standardized breakfast delayed the time to peak plasma moricizine concentration (1.2 vs. 0.9 hr; P less than .03) and lowered peak plasma moricizine concentration by 24% (0.55 vs. 0.72 microgram/mL; P less than .03). Bioavailability, as measured by area under the plasma moricizine concentration versus time curve, was not significantly altered by the meal.
Pieniaszek
H J
HJ
Drug Metabolism and Pharmacokinetics Section, Du Pont Merck Pharmaceutical Company, Newark, DE 19714.
Rakestraw
D C
DC
Schary
W L
WL
Williams
R L
RL
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D005215:Fasting / Q000378:metabolism; D005502:Food; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D008297:Male; D016293:Moricizine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D016293:Moricizine