title: High prevalence & heterogenicity of thalassaemias in Orissa.
abstract: High incidence of alpha thalassaemias (estimated from detection of Hb Bart's from cord blood), Hb constant spring (CS) and high A2 beta thalassaemia trait (estimated from normal adult subjects) were detected in 12.6, 15 and 8 per cent people of coastal Orissa (with less than 5% tribal population) respectively. Quantitation of Hb Bart's suggest that the alpha thalassaemia could be any of the genotypes such as, -alpha/alpha alpha, -alpha/-alpha, --/alpha alpha and alpha alpha/alpha alpha cs. Both heterozygotes and homozygotes for Hb CS were identified.
authors.affiliation: Department of Pathology, SCB Medical College, Cuttack.
authors.forename: R C
authors.initials: RC
authors.lastname: Misra
authors.forename: B
authors.initials: B
authors.lastname: Ram
authors.forename: B C
authors.initials: BC
authors.lastname: Mohapatra
authors.forename: S N
authors.initials: SN
authors.lastname: Das
authors.forename: S C
authors.initials: SC
authors.lastname: Misra
mesh_terms: D005312:Fetal Blood / Q000737:chemistry; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006801:Humans; D007194:India / Q000453:epidemiology; D015995:Prevalence; D013789:Thalassemia / Q000453:epidemiology* / Q000235:genetics
chemical_list: D006455:Hemoglobins, Abnormal; C030448:hemoglobin Bart's; C035541:Hemoglobin Constant Spring