title: The magnetic properties of some materials affecting MR images.
abstract: We have compared the magnetic properties of various types of materials known to affect MR images. The materials compared were: (i) MR contrast agents based on chelates of paramagnetic metals (Gd-DTPA, Dy-DTPA); (ii) biological forms of iron (horse spleen ferritin and deoxyhemoglobin); and (iii) a superparamagnetic iron oxide (AMI-25). The properties compared were the magnetic susceptibility and the magnetization. The magnetization and susceptibility of superparamagnetic AMI-25 are far larger than that of ferritin or low molecular weight, paramagnetic chelates. Superparamagnetic iron oxide colloids, like AMI-25, are a uniquely powerful class of magnetic materials.
authors.affiliation: Advanced Magnetics, Inc., Cambridge, Massachusetts 02138.
authors.forename: L
authors.initials: L
authors.lastname: Josephson
authors.forename: J
authors.initials: J
authors.lastname: Bigler
authors.forename: D
authors.initials: D
authors.lastname: White
mesh_terms: D000818:Animals; D003287:Contrast Media; D003911:Dextrans; D005293:Ferritins; D052203:Ferrosoferric Oxide; D019786:Gadolinium DTPA; D006454:Hemoglobins; D006801:Humans; D007501:Iron; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D009942:Organometallic Compounds; D010087:Oxides; D004369:Pentetic Acid / Q000031:analogs & derivatives
chemical_list: D003287:Contrast Media; D003911:Dextrans; D006454:Hemoglobins; D058185:Magnetite Nanoparticles; D009942:Organometallic Compounds; D010087:Oxides; D004369:Pentetic Acid; D005293:Ferritins; C100003:deoxyhemoglobin; C055865:dysprosium DTPA; D007501:Iron; C065507:ferumoxides; D019786:Gadolinium DTPA; D052203:Ferrosoferric Oxide