title: Idiopathic acute interstitial nephritis associated with uveitis.
abstract: A case of acute interstitial nephritis associated with uveitis is presented, An 18-year-old man developed uveitis followed by renal dysfunction. Moderate renal dysfunction (sCr 3.0 mg/dl), and increased levels of urinary beta 2 microglobulin (over 8,000 micrograms/I) were observed. Renal tissue obtained by open renal biopsy revealed severe infiltration of mononuclear cells in the tubulo-interstitial area. The majority of infiltrating cells were CD4-positive T cells demonstrated by immunoperoxidase staining, suggesting the involvement of T cell-mediated delayed hypersensitivity. Corticosteroid was effective against both uveitis and renal dysfunction. The possible pathogenesis of this syndrome is reviewed from the literature.
authors.affiliation: Department of Internal Medicine, School of Medicine, Tokai University, Isehara, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yano
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: M
authors.initials: M
authors.lastname: Endoh
authors.forename: T
authors.initials: T
authors.lastname: Kuramoto
authors.forename: K
authors.initials: K
authors.lastname: Eguchi
authors.forename: M
authors.initials: M
authors.lastname: Yagame
authors.forename: Y
authors.initials: Y
authors.lastname: Nomoto
authors.forename: H
authors.initials: H
authors.lastname: Sakai
mesh_terms: D000293:Adolescent; D006801:Humans; D006968:Hypersensitivity, Delayed; D008297:Male; D009395:Nephritis, Interstitial / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use; D013577:Syndrome; D013601:T-Lymphocytes / Q000276:immunology; D014605:Uveitis / Q000150:complications* / Q000188:drug therapy / Q000209:etiology
chemical_list: D011239:Prednisolone