title: Analysis of the influence of vasopressin neuropeptides on social recognition of rats.
abstract: The facilitatory effect of vasopressin neuropeptides on social recognition of adult male rats was analyzed. The decrease of social investigation behaviors during a second encounter with the same juvenile rat served as index for social recognition. Treatment with desglycinamide-(Arg8)-vasopressin (6 mg.kg-1, s.c.) extended the time that adults recognize the same juvenile from 30 min to 24 h. Structure-activity studies revealed that the effect of vasopressin neuropeptides on social recognition resides in the 5-8 part of the AVP molecule. The peptide (pGlu4,Cyt6) AVP-(4-8) was more potent than DGAVP in this behavioral paradigm. These effects bear similarities with the memory enhancing effects of vasopressin neuropeptides as found in other test procedures.
authors.affiliation: Department of Pharmacology, Rudolf Magnus Institute, Medical Faculty, University of Utrecht, The Nederlands.
authors.forename: R
authors.initials: R
authors.lastname: Sekiguchi
authors.forename: G
authors.initials: G
authors.lastname: Wolterink
authors.forename: J M
authors.initials: JM
authors.lastname: van Ree
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects; D009479:Neuropeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012919:Social Behavior; D013329:Structure-Activity Relationship; D014667:Vasopressins / Q000494:pharmacology*
chemical_list: D009479:Neuropeptides; D014667:Vasopressins; D001127:Arginine Vasopressin