Immunoadjuvant properties of chitosan.
Adjuvant activity of water insoluble chitosan suspension was examined in CBA mice. Among different types of immune reaction only T-dependent humoral response against SRBC was enhanced by injection of chitosan. The optimal conditions of administration of both agents (antigen-SRBC, adjuvant-chitosan) was established.
Marcinkiewicz
J
J
Department of Experimental and Clinical Immunology, Nicholas Copernicus Medical Academy, Czysta, Kraków.
Polewska
A
A
Knapczyk
J
J
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000941:Antigens / Q000008:administration & dosage; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002686:Chitin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D048271:Chitosan; D004912:Erythrocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012756:Sheep; D012995:Solubility; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D000941:Antigens; D002686:Chitin; D048271:Chitosan