[Immunomodulatory effect of Consupren Sol. Spofa (cyclosporin A). Preclinical study].
Consupren Spofa was demonstrated in our tests to be a distinguished immunomudulating agent. The preparation did not show any direct lymphotoxicity or myelotoxicity but it markedly influenced maturation of T lymphocytes in the thymus. When testing the functional activity of the immunity system in vivo, the inhibitory effect of Consupren Spofa was manifested only when administering a relatively larger dose of the drug with an antigenic stimulus or shortly after it, i.e., in the period of early activating processes. The use of a suitable time and dosage regimen is therefore decisive to induce an inhibitory effect. On the basis of comparative experiments it can be stated that Consupren Spofa is minimally as much effective as, or in some experiments even more effective than Sandimmun Sandoz.
Panajatovová
V
V
Výkumný ústav pro farmacii a biochemii, Praha.
Lastovicka
J
J
Grimová
J
J
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology*; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects; D007109:Immunity / Q000187:drug effects*; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL
D016572:Cyclosporine
Imunomodulacní úcinky Consuprenu Sol. Spofa (cyklosporinu A). Preklinická studie.