title: Genetic polymorphism of the C4 component of human complement in the Slovak population.
abstract: The distribution of C4 phenotypes and gene frequencies were studied in 104 genetically unrelated persons of Slovakia using high-voltage agarose gel electrophoresis with subsequent immunofixation. Five C4A alleles and three C4B alleles were detected. The gene frequencies were as follows: A2 = 0.0576, A3 = 0.7644, A4 = 0.0336, A6 = 0.0625, AQ0 = 0.817, B1 = 0.7836, B2 = 0.1009, BQ0 = 0.1153. The C4AQ0 and C4BQ0 alleles established by densitometry appeared in the Slovak population in 16.34% and 23.07%, respectively.
authors.affiliation: Department of Microbiology and Immunology, Medical Faculty, Commenius University, Bratislava.
authors.forename: D
authors.initials: D
authors.lastname: Staneková
authors.forename: Z
authors.initials: Z
authors.lastname: Starsia
authors.forename: J
authors.initials: J
authors.lastname: Valúch
mesh_terms: D000293:Adolescent; D000328:Adult; D003181:Complement C4 / Q000032:analysis / Q000235:genetics*; D015934:Complement C4a; D015935:Complement C4b; D003604:Czechoslovakia / Q000208:ethnology; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People
chemical_list: D003181:Complement C4; D015934:Complement C4a; D015935:Complement C4b