title: Management of chronic active B hepatitis with alpha interferon.
abstract: Patients with chronic active B hepatitis entered into an open study of IFN maintenance therapy. They received 3 x 10(6) I.U. INTRON-A by subcutaneous injection three times a week for a 4-month period. Four patients out of ten became HBeAg negative and anti-HBe, which was accompanied by the return of serum liver function tests to normal. In a control group with eleven patients, given only vitamins, no changes were registered in serological and biochemical data. Fever, "flu-like illness", fatigue were the main side-effects observed during the course of IFN therapy, which had not to be discontinued.
authors.affiliation: Institute for Infectious and Tropical Diseases, Medical Faculty University, Beograd.
authors.forename: S
authors.initials: S
authors.lastname: Gróza
authors.forename: L
authors.initials: L
authors.lastname: Vukotić
authors.forename: L
authors.initials: L
authors.lastname: Jemuovoć
authors.forename: D
authors.initials: D
authors.lastname: Delić
authors.forename: P
authors.initials: P
authors.lastname: Nikolić
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007279:Injections, Subcutaneous; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D016898:Interferon-alpha