title: [Studies on the chemical constituents of the root of Cocculus Trilobus DC].
abstract: Four bisbenzylisoquinoline alkaloids (I-IV) have been isolated from the roots of Cocculus trilobus DC. (Menispermaceae) growing wild in the mountainous areas of Zhejiang province. Their structures were established as isotrilobine (I), trilobine (II), isotrilobine-N-2-oxide (III) and nortrilobine (IV) on the basis of spectral analysis (UV, IR, HNMR,MS), physico-chemical constants and properties of the derivatives. III is a new alkaloid and IV was found from this plant for the first time.
authors.affiliation: School of Pharmacy, Second Military medical University, Shanghai.
authors.forename: H S
authors.initials: HS
authors.lastname: Chen
authors.forename: H Q
authors.initials: HQ
authors.lastname: Liang
authors.forename: S X
authors.initials: SX
authors.lastname: Liao
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007941:Leukemia P388 / Q000473:pathology; D015394:Molecular Structure; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; C076299:isotrilobine-N-2-oxide