title: An aqueous extract of guaraná (Paullinia cupana) decreases platelet thromboxane synthesis.
abstract: The effects of an aqueous extract of guaraná (Paullinia cupana) on rabbit platelet aggregation and thromboxane synthesis were examined. The guaraná extract (100 mg/ml) and fractions separated by TLC (origin and xanthines) decreased platelet aggregation (37, 27 and 31% of control values, respectively) and platelet thromboxane formation from [14C]-arachidonic acid (78, 70 and 50% of control values, respectively). The decreased thromboxane synthesis could be responsible, at least in part, for the antiaggregatory action of guaraná.
authors.affiliation: Fundação Pró-Sangue Hemocentro de São Paulo, Faculdade de Medicina, Universidade de São Paulo, Brasil.
authors.forename: S P
authors.initials: SP
authors.lastname: Bydlowski
authors.forename: E A
authors.initials: EA
authors.lastname: D'Amico
authors.forename: D A
authors.initials: DA
authors.lastname: Chamone
mesh_terms: D000818:Animals; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors; D011817:Rabbits; D013931:Thromboxanes / Q000096:biosynthesis*
chemical_list: D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D013931:Thromboxanes