Intestinal absorption kinetics of a series of aminopenicillins and azidocillin. A comparative study in the rat.
Intestinal absorption rate constants of amoxicillin, ampicillin, epicillin, cyclacillin and azidocillin, by means of a static in situ intestinal perfusion method has been estimated. Luminal remaining antibiotic concentrations were determined using a standard microbiological technique. In order to establish statistically better absorption kinetics, five dose levels were used, ranging from 10 to 1000 micrograms/ml, and first order, Michaelis-Menten and combined first-order and Michaelis-Menten differential model equations were fitted to experimental data found for each antibiotic. According to the AIC test, the best equation for absorption kinetics was selected. Amoxicillin and ampicillin absorption mechanisms were better described by combined kinetics, while for cyclacillin and epicillin the most probable kinetics was that of Michaelis-Menten. For azidocillin, the only non-aminopenicillin component of this series, first order kinetics should be statistically selected.
Margarit
F
F
Department of Pharmacy, University of Barcelona, Spain.
Moreno-Dalmau
J
J
Obach
R
R
Peraire
C
C
Plá-Delfina
J M
JM
D000658:Amoxicillin / Q000493:pharmacokinetics; D000667:Ampicillin / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D000818:Animals; D003493:Cyclacillin / Q000493:pharmacokinetics; D007408:Intestinal Absorption; D008297:Male; D008954:Models, Biological; D010400:Penicillin G / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D010406:Penicillins / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D010406:Penicillins; C100212:epicillin; D003493:Cyclacillin; D000667:Ampicillin; D000658:Amoxicillin; D010400:Penicillin G; C100243:azidocillin