title: [The efficacy of a cultured rabies vaccine studied in guinea pigs preliminarily infected with a fixed rabies virus].
abstract: In experiments of curative vaccination, carried out with the use of an experimental model similar to the current practice of treatment with antirabies preparations, the advantages of using tissue-culture rabies vaccine with immunogenic potency equal to 1.3 international units (I. U.) were shown. In these experiments the vaccine was introduced into guinea pigs infected with fixed rabies virus, the course of vaccination consisting of 14 daily injections. No correlation between the induction of virus-neutralizing antibodies and the immunogenic potency of tissue-culture rabies vaccine was established: the use of the vaccine with immunogenic potency equal to 0,3 and 1,3 I.U. had no essential influence on the level of antibody formation in the animals.
authors.forename: A A
authors.initials: AA
authors.lastname: Movsesiants
authors.forename: L N
authors.initials: LN
authors.lastname: Romanova
authors.forename: E M
authors.initials: EM
authors.lastname: Tsetlin
authors.forename: R Ia
authors.initials: RIa
authors.lastname: Shkol'nik
authors.forename: P V
authors.initials: PV
authors.lastname: Kolotvina
authors.forename: S V
authors.initials: SV
authors.lastname: Gribencha
authors.forename: I F
authors.initials: IF
authors.lastname: Barinskiĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Kasatkin
authors.forename: A A
authors.initials: AA
authors.lastname: Sumarokov
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D051379:Mice; D009500:Neutralization Tests; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology / Q000472:pathogenicity; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines
vernacular_title: Izuchenie éffektivnosti kul'tural'noĭ antirabicheskoĭ vaktsiny na morskikh svinkakh v usloviiakh predvaritel'nogo zarazheniia ikh fiksirovannym virusom beshenstva.