COR3224--a new antidepressant: pharmacokinetics and metabolism in rat.
COR3224 is a new 2-amino-2 oxazoline derivative with antidepressant properties. The distribution, excretion and metabolism of radiochemically labelled 14C-COR3224 has been investigated in the rat after intravenous injection. The compound was widely distributed and rapidly excreted. Hydroxylation and sulphate conjugation are involved in the COR3224 elimination.
Neau
B
B
Centre de Recherche, Laboratories Sorget, Mérignac, France.
Damaj
I
I
Lambrey
B
B
Akbaraly
J P
JP
Roux
J
J
Perrissoud
D
D
Jacquot
J
J
D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D005243:Feces / Q000737:chemistry; D006207:Half-Life; D006900:Hydroxylation; D007275:Injections, Intravenous; D008297:Male; D010080:Oxazoles / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000378:metabolism
D000928:Antidepressive Agents; D010080:Oxazoles; D013431:Sulfates; C056984:COR 32-24