Omphalone, an antibiotically active benzoquinone derivative from fermentations of Lentinellus omphalodes.
Omphalone, a new antibiotic, cytotoxic, and phytotoxic pigment has been isolated from fermentations of a Canadian strain of Lentinellus omphalodes. Its structure has been established as 2-(4-methylfuran-2-yl)-1,4-benzoquinone (1) by spectroscopic investigations and conversion into leuco-acetate 2.
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LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland.
Anke
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Mocek
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D000935:Antifungal Agents / Q000302:isolation & purification*; D001419:Bacteria / Q000187:drug effects*; D001487:Basidiomycota / Q000254:growth & development*; D016227:Benzoquinones / Q000302:isolation & purification / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D004261:DNA Replication / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D012639:Seeds / Q000187:drug effects; D013053:Spectrophotometry
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D016227:Benzoquinones; D004273:DNA, Neoplasm; D005663:Furans; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; C074983:omphalone