[Disordered sympathetic regulation of the functions of the cardiovascular system in rats with streptozotocin diabetes].
The effect of sympathomimetic tyramine on the systemic and regional hemodynamic parameters was studied by the radioactive microsphere technique in experiments on conscious streptozotocin-diabetic and age-matched control rats. The dose of tyramine required for blood pressure elevation on 15-20 mm Hg was 5.6 times as large in diabetic rats as compared to control animals. It was suggested that sympathetic neuropathy may play the role in the development of the cardiovascular alterations in streptozotocin-diabetic rats.
Medvedeva
N A
NA
Kuznetsova
L V
LV
Medvedev
O S
OS
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*
D000661:Amphetamine; D009638:Norepinephrine
Narushenie simpaticheskoĭ reguliatsii funktsiĭ serdechno-sosudistoĭ sistemy u krys so streptozototsinovym diabetom.