title: Dexamethasone bovine pharmacokinetics.
abstract: Dexamethasone phosphate (DXM-PHO) is an ester which is quickly hydrolysed by the bovine and the dexamethasone (DXM) plasma half-life was 5.16 h. It has been demonstrated that 54 h after DXM-PHO injection, DXM concentrations were lower than 0.1 mg/ml. Tritiated dexamethasone was also administered twice to an another young bull for metabolite investigation. The elapsed time required to recover, in plasma, half of the radioactivity injected was 8.8 h. Radioactivity recovery in the urine reached 36.4% and 22.6% for the first and the second injections respectively.
authors.affiliation: Department of General and Organic Chemistry, Faculty of Agricultural Sciences, Gembloux, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Gaignage
authors.forename: G
authors.initials: G
authors.lastname: Lognay
authors.forename: D
authors.initials: D
authors.lastname: Bosson
authors.forename: D
authors.initials: D
authors.lastname: Vertongen
authors.forename: P
authors.initials: P
authors.lastname: Dreze
authors.forename: M
authors.initials: M
authors.lastname: Marlier
authors.forename: M
authors.initials: M
authors.lastname: Severin
mesh_terms: D000818:Animals; D002417:Cattle; D003907:Dexamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006207:Half-Life; D006868:Hydrolysis; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D012044:Regression Analysis
chemical_list: C004180:dexamethasone 21-phosphate; D003907:Dexamethasone