[Neurochemical disorders in rats caused by combined action of Primor and thiram. I. Changes in catecholamine and serotonin levels in the brain, heart and adrenal glands of rats with acute poisoning].
Study was made of the effect of acute poisoning with primor or with an equitoxic mixture of primor/tiuram (oral dose amounting to 50% of LD50) on the dynamic equilibrium of catecholamines and serotonin in rat whole brain, anatomic parts of the brain, heart and suprarenal glands. Both primor and an equitoxic mixture of primor/tiuram were found to cause changes in the levels of the investigated neurotransmitters in the central and peripheral nervous system. The mixture, as compared with primor alone, displayed the same direction of action, but the changes proceeded with enhanced dynamics and lasted throughout the whole experimental period (12h). The action of primor alone usually manifested itself only during the first hour after poisoning. Both primor and an equitoxic mixture of primor/tiuram exhibited no selective affinity to any separate areas of the brain, and lowered the contents of dopamine and norepinephrine in all brain structures studied.
Biel-Zielińska
A
A
Zakład Toksykologii akademii Medycznej w Warszawie.
Brzeziński
J
J
D000208:Acute Disease; D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002219:Carbamates / Q000008:administration & dosage / Q000506:poisoning*; D002395:Catecholamines / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003864:Depression, Chemical; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006321:Heart / Q000187:drug effects*; D007306:Insecticides / Q000008:administration & dosage / Q000506:poisoning*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011743:Pyrimidines / Q000008:administration & dosage / Q000506:poisoning*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013268:Stimulation, Chemical; D013893:Thiram / Q000008:administration & dosage / Q000506:poisoning*
D002219:Carbamates; D002395:Catecholamines; D004338:Drug Combinations; D007306:Insecticides; D011743:Pyrimidines; D013893:Thiram; D012701:Serotonin; C073893:primor
Zaburzenia neurochemiczne w ustroju szczura przy łacznym oddziaływaniu primoru i tiuramu. CZ. I. Zmiany poziomów amin katecholowych i serotoniny w mózgu, sercu i nadnerczach szczura w warunkach zatrucia ostrego.