[Sensitivity of yeasts of the genus Candida to new antifungal agents].
We studied the in vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole and ciclopirox, as well other classical antifungal agents against 188 Candida spp. strains. Minimum inhibitory concentrations (MIC) have been determined by dilution-agar technique. Of all the imidazole compound tested, isoconazole showed the greatest activity against 186 Candida strains isolates (MIC 90%: 4 micrograms/ml). Sulconazole and cloconazole showed their best activity against 106 Candida albicans isolates. Butoconazole and isoconazole had demonstrated good activity against C. albicans and also were the most active agents against 80 Candida spp. isolates. In vitro activity of ciclopirox against Candida is close to that of econazole (MIC 90%: 8 micrograms/ml).
Hernández-Molina
J M
JM
Servicio de Microbiología, Hospital Virgen de las Nieves, Granada.
Llosá
J
J
Martínez-Brocal
A
A
de la Rosa
M
M
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
D000935:Antifungal Agents; D000666:Amphotericin B
Sensibilidad de levaduras del género Candida a nuevos agentes antifúngicos.