Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.
The effects of prednisolone, salbutamol or theophylline treatment were studied in guinea pigs on bronchial hyperreactivity induced by chronic administration of PAF, (subsequently measuring respiratory flow after an intravenous injection of histamine) and the chemokinesis of leucocytes in vitro. Prednisolone (10 mg/kg p.o.) was active in the bronchial hyperreactivity test, as was salbutamol, but its effect appeared to be more related to its bronchodilator activity per se, while theophylline had little activity in this test. Regarding leucocyte chemokinetic activity, prednisolone and theophylline inhibited this at nM and microM concentrations respectively, whereas salbutamol was weakly active in this test.
Llupiá
J
J
Division of Biological Sciences, Laboratorios Almirall, Barcelona, Spain.
Fernández
A G
AG
Berga
P
P
Gristwood
R W
RW
D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D016535:Bronchial Hyperreactivity / Q000188:drug therapy*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006168:Guinea Pigs; D008297:Male; D010972:Platelet Activating Factor; D011239:Prednisolone / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology*
D010972:Platelet Activating Factor; D011239:Prednisolone; D013806:Theophylline; D000420:Albuterol