[Testing for the safety, reactogenicity and antigenic properties of a live thermostable mumps vaccine made from the Leningrad-3 strain].
A live mumps vaccine (LMV) from strain Leningrad-3 with a new stabilizer LS-18 was tested for reactogenicity and antigenic potency. Examinations of vaccinated children for vaccination reactions showed its complete areactogenicity and safety. LMV induced synthesis of virus-neutralizing antibodies in 78-82% of the vaccinees. Determinations of the dynamics, intensity and duration of circulation of specific antihemagglutinating, antineuraminidase and virus-neutralizing antibodies demonstrated marked antigenic potency of the LMV and established production of earliest specific antineuraminidase antibodies in 75% of the vaccinees. EIA was found to be the most sensitive test.
Iuminova
H V
HV
Liashenko
V A
VA
Krasnova
V P
VP
Krivenkova
V N
VN
Goliazhenkova
M Iu
MIu
Unanov
S S
SS
D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000009:adverse effects* / Q000276:immunology; D002675:Child, Preschool; D004341:Drug Evaluation; D004355:Drug Stability; D006801:Humans; D009031:Moscow; D009108:Mumps Vaccine / Q000009:adverse effects* / Q000276:immunology; D009109:Mumps virus / Q000276:immunology*; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D009108:Mumps Vaccine; D014613:Vaccines, Attenuated
Proverka bezopasnosti, reaktogennosti i antigennykh svoĭstv zhivoĭ parotitnoĭ termostabil'noĭ vaktsiny iz shtamma Leningrad-3.