[The blocking effect of topically subepithelial injection of thioproline and vitamin A acid in experimental oral premalignant].
The purpose of this paper is to observe the blocking effect of topically subepithelial injected drug and Vit A acid painting on chemically induced oral precancerous lesion and to prove, on a certain extent, the hypothesis that subepithelial connective tissue could exert great influence on the differentiation of the epithelium. A total of 49 syrian hamster was used as experimental animal. Both buccal pouches of all animals were painted thrice weekly with 0.5% DMBA in acetone for 6 weeks. Then, they were divided into two groups: Control group and Experimental group. In the latter group, 70.8% precancerous lesions turned into normal epithelial tissue, whereas those untreated animals developed carcinoma by 62%.
Xie
J F
JF
School of Stomatology, Beijing Medical University.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002610:Cheek; D006224:Cricetinae; D004848:Epithelium / Q000473:pathology; D007267:Injections; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D011230:Precancerous Conditions / Q000139:chemically induced / Q000188:drug therapy*; D013844:Thiazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D053778:Thiazolidines; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D013844:Thiazoles; D053778:Thiazolidines; D014212:Tretinoin; D015127:9,10-Dimethyl-1,2-benzanthracene; C003438:thiazolidine-4-carboxylic acid