Nitrogranulogen enhances IL-1 production but decreases cellular sensitivity to this cytokine.
An alkylating agent, nitrogranulogen, enhances the in vitro production of interleukin 1 by human monocytes. On the other hand, the drug inhibits proliferative responses of mouse thymocytes to exogenously added IL-1. Our results may shed light on the mechanisms of anti-inflammatory action of immunosuppressive agents.
Stepień-Sopniewska
B
B
Department of Immunology, Warsaw Medical School.
Ołdakowska
U
U
Wasik
M
M
Juskowa
J
J
Górski
A
A
D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D008213:Lymphocyte Activation; D008466:Mechlorethamine / Q000494:pharmacology*; D051379:Mice; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000276:immunology*
D007375:Interleukin-1; D008466:Mechlorethamine