Effects of residual sodium hyaluronate on postsurgical blood-aqueous barrier.
The effects of residual sodium hyaluronate (HA) on the postsurgical blood-aqueous barrier (BAB) function were investigated in 79 posterior chamber lens (PCL)-implanted eyes after both extracapsular cataract extraction and PCL implantation using HA products. The amount of residual HA was classified according to the status of the aqueous warm current on the 1st postoperative day. The eyes with static warm current were classified into the static current group and the other eyes into the normal current group. Aqueous flare intensity and cell number were measured in all eyes daily from the 1st to the 7th postoperative day using the flare-cell meter. Of the 79 eyes, 11 eyes (14%) were classified into the static current group. Flare intensity showed the most marked difference between the two groups on the 1st postoperative day. The difference was statistically significant from the 1st to the 7th postoperative days (P less than 0.05). Cell count was also higher in the static current group throughout the observation period except for the 3rd and 4th postoperative days (P less than 0.05). These findings suggest that residual HA exacerbated the postoperative inflammation and that its effects on the BAB continued for at least a week.
Tsurimaki
Y
Y
Department of Ophthalmology, Jichi Medical School, Tochigi, Japan.
Shimizu
H
H
D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D001693:Biological Transport, Active; D001769:Blood / Q000378:metabolism*; D002387:Cataract Extraction; D002452:Cell Count; D009877:Endophthalmitis / Q000209:etiology; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000493:pharmacokinetics*; D007910:Lenses, Intraocular; D008297:Male; D011183:Postoperative Complications
D006820:Hyaluronic Acid