[Nuclear magnetic resonance and iron overload in thalassemia].
We assessed the iron load content in 36 beta-thalassemia patients by NMR correlating the results with serum ferritin levels. 22 of them were affected by beta-thalassemia major on hyper-transfusional regimen (Group A), 4 by beta-thalassemia intermedia (Group B) and 10 by beta-thalassemia major, who had been previously bone marrow transplanted (Group C). In A and C Groups the liver showed the lowest signal intensity on spin echo images (p less than 0.01; p less than 0.06, respectively). A significant correlation between the summation of signals obtained from all the examined organs and serum ferritin levels was observed by evaluating both all the patients globally (r = 0.78; p less than 0.001) and the A and C Group patients. This correlation was confirmed only in the liver both in all the patients (r = 0.77; p less than 0.001) and in A and C Group patients, when the signals obtained from each organ were evaluated.
Schettini
F
F
Istituto di Pediatria Clinica e Preventiva, Università di Bari.
De Mattia
D
D
Cavallo
L
L
Sabato
V
V
Santoro
N
N
Del Vecchio
G C
GC
Martinelli
G
G
Martinelli
A
A
Di Bartolomeo
P
P
Di Girolamo
G
G
D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D010179:Pancreas / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D013789:Thalassemia / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy
D005293:Ferritins; D007501:Iron
Risonanza magnetica nucleare e sovraccarico marziale nella talassemia.