Altered protein synthesis rate in ovaries of D. melanogaster caused by new antitumour alkylating agents.
1. The effect of two homo-aza-steroidal esters with antineoplastic activity, namely 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminoph enoxyacetate (NSC 294859) and 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminoph enylacetate (ASE) on protein synthesis rate was studied in ovaries of Drosophila melanogaster females. 2. Two different concentrations for each compound were examined. 3. Both esters containing the same alkylating agent have been shown to decrease protein synthesis in relation to control.
Stephanou
G
G
Department of Biology, University of Patras, Greece.
Demopoulos
N A
NA
Catsoulacos
P
P
D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001378:Azasteroids / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology*; D004331:Drosophila melanogaster; D005260:Female; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D001378:Azasteroids; D009588:Nitrogen Mustard Compounds; C017888:NSC 290205; C038583:NSC 294859