Clinico-biochemical study of experimental complicated cataracts.
Clinically observed complicated cataracts, generally do not have a definite causal factor. We studied the effects of E. coli toxin injected suprachoroidally, to simulate the effect of toxins released by extraocular organisms on the lens. 79.2% of eyes had a definable cataract at the end of the 6th week of observation. The biochemical changes portrayed an increased oxidative activity in the lens, evidenced by a fall in glutathione concentration, and the consequent tertiary reorientation of proteins to increase insoluble proteins, forming a cataract.
Sihota
R
R
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.
Mohan
M
M
Angra
S K
SK
Mathur
R L
RL
D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis; D002386:Cataract / Q000378:metabolism*; D003459:Crystallins / Q000032:analysis; D004195:Disease Models, Animal; D004731:Endotoxins; D004926:Escherichia coli; D007908:Lens, Crystalline / Q000378:metabolism*; D008070:Lipopolysaccharides; D011817:Rabbits
D003459:Crystallins; D004731:Endotoxins; D008070:Lipopolysaccharides; C044101:endotoxin, Escherichia coli; D001205:Ascorbic Acid