title: [Prospective randomized study of the comparison of the effectiveness of cefoxitin (triple dose) and cefuroxime (single shot) in preventive perioperative use of antibiotics in abdominal surgery].
abstract: In a prospective, randomized trial in 200 patients who underwent abdominal surgery, we compared the prophylactic effect of a single dose of 1.5 g Cefuroxime against three doses of 2 g Cefoxitin. The incidence of wound infections was 8.2% in both groups. No difference was found between the two groups in the incidence of other infections except for urinary tract infections, whose frequency was twice as high in the Cefuroxime-treated group. In all patients we swabbed material from the anastomosis for microbiological investigation. However, these results did not enable the prediction of a wound infection or the determination as to which specimen caused the infection. In our pharmacokinetic investigations we obtained better results in the Cefuroxime-treated group due to the drug's longer half-life. On the other hand, we found extreme interindividual variation in the results obtained in both groups. This not well known factor probably raises the incidence of wound infection.
authors.affiliation: Chirurgische Klinik, RWTH Aachen.
authors.forename: J
authors.initials: J
authors.lastname: Nachtkamp
authors.forename: C
authors.initials: C
authors.lastname: Peiper
authors.forename: V
authors.initials: V
authors.lastname: Schumpelick
mesh_terms: D002440:Cefoxitin / Q000008:administration & dosage*; D002444:Cefuroxime / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005767:Gastrointestinal Diseases / Q000601:surgery*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011292:Premedication; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D002440:Cefoxitin; D002444:Cefuroxime
vernacular_title: Prospektive randomisierte Studie zum Vergleich der Wirksamkeit von Cefoxitin (3fache Gabe) und Cefurexim (Single-Shot) in der perioperativen Antibiotikaprophylaxe in der Abdominalchirurgie.