title: [The assessment of skeletal age in hypothyroidism during the first year of life. The features of a new method].
abstract: Determining skeletal maturity in the first year of age with usual methods is often quite difficult. Some years ago, we investigated a new method based on the time of appearance of appreciable ossification centres in the upper limbs with the following succession: humerus head, capitate, coracoid process, hamate, humerus capitulum, greater tuberosity and radius distal epiphysis; in the first month of age it must be associated to knee and foot study. We studied with our method the skeletal maturity of 16 hypothyroid patients before and after 6 and 12 months of therapy; in the first month of age we associated the study of left knee and foot and study of left hand and wrist using Greulich and Pyle's method at 12 months of age. We compared data of hypothyroid patients to data of 399 infants hospitalized in Pediatric Clinic of Florence for infectious diseases or for neonatal hyperbilirubinemia. Our study has showed that skeletal maturity, retarded before therapy, rejoined normal values over a period of time of 12 months of substitutive treatment; it was accelerated in some patients.
authors.affiliation: Clinica Pediatrica II, Università degli Studi di Firenze, Italia.
authors.forename: R
authors.initials: R
authors.lastname: Salti
authors.forename: F
authors.initials: F
authors.lastname: Galluzzi
authors.forename: A
authors.initials: A
authors.lastname: Albanese
authors.forename: A
authors.initials: A
authors.lastname: Morandi
authors.forename: F
authors.initials: F
authors.lastname: La Cauza
authors.forename: G F
authors.initials: GF
authors.lastname: Vichi
authors.forename: G
authors.initials: G
authors.lastname: Natoli
mesh_terms: D000365:Age Determination by Skeleton / Q000379:methods*; D001132:Arm / Q000000981:diagnostic imaging; D001846:Bone Development; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000188:drug therapy; D007223:Infant; D007231:Infant, Newborn; D007233:Infant, Postmature; D008297:Male
vernacular_title: La valutazione dell'età scheletrica nell'ipotiroidismo durante il primo anno di vita. Rilievi con un nuovo metodo.