Specific T-cell response to a Pneumocystis carinii surface glycoprotein (gp120).
Pneumocystis carinii gp120 can elicit a specific T-cell proliferative response in mice after immunization with a gp120 preparation or with a crude P. carinii homogenate. It can also elicit a proliferative response from SCID mice after recovery from natural infection with P. carinii, implicating this glycoprotein as an important antigen in the host's response to P. carinii infection.
Fisher
D J
DJ
Department of Pediatrics, University of Rochester, School of Medicine and Dentistry, NY 14642.
Gigliotti
F
F
Zauderer
M
M
Harmsen
A G
AG
D000818:Animals; D015153:Blotting, Western; D005656:Fungal Proteins / Q000276:immunology*; D007114:Immunization; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D011010:Pneumocystis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D005656:Fungal Proteins; D008562:Membrane Glycoproteins