title: Aortic valve/root interactions in porcine hearts: implications for bioprosthetic valve sizing.
abstract: The implantation of aortic allografts as well as stentless, freehand porcine xenograft valves requires proper sizing of the graft for the recipient aortic root. To visualize the aortic valve in motion and measure the cyclic expansion of the aortic root, we developed an isolated porcine heart model and a computerized three-dimensional reconstruction technique. Dynamic and static expansions of the aortic root were obtained from beating and arrested porcine hearts, and additional static expansions at varying pressures were measured from reconstructed three-dimensional models of valves obtained with high-resolution magnetic resonance imaging. Measurements of aortic root expansion have shown that it is highly dependent upon the pressures imposed on the heart. Although the aortic root expanded by only 5% between systolic pressures of 60 and 100 mmHg, the total expansion was up to 40% between rest and cyclic pressurizing to 100 mmHg. This data suggest that unstented xenograft valves should be sized 30% to 40% larger than the collapsed size of the recipient aorta. Proper sizing of valves on stents should also be attempted to reduce the large amount of leaflet redundancy that current stenting techniques produce.
authors.affiliation: John P. Robarts Research Institute, University of Western Ontario, Canada.
authors.forename: I
authors.initials: I
authors.lastname: Vesely
authors.forename: A H
authors.initials: AH
authors.lastname: Menkis
authors.forename: B
authors.initials: B
authors.lastname: Rutt
authors.forename: G
authors.initials: G
authors.lastname: Campbell
mesh_terms: D000818:Animals; D001011:Aorta / Q000033:anatomy & histology* / Q000601:surgery; D001021:Aortic Valve / Q000033:anatomy & histology* / Q000601:surgery; D001705:Bioprosthesis; D003196:Computer Graphics; D004195:Disease Models, Animal; D005260:Female; D006350:Heart Valve Prosthesis; D008279:Magnetic Resonance Imaging; D011474:Prosthesis Design; D015607:Stents; D013552:Swine; D014184:Transplantation, Homologous