Biosynthesis of beta-(isoxazolin-5-on-2-yl)alanine, the precursor of the neurotoxic amino acid beta-N-oxalyl-L-alpha,beta-diaminopropionic acid.
beta-(Isoxazolin-5-on-2-yl)alanine (BIA), a biosynthetic precursor of the neurotoxic amino acid beta-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), was confirmed to be derived from O-acetyl-L-serine (OAS) and isoxazolin-5-one by cysteine synthase in higher plants. Some properties of this enzyme in the biosynthesis of BIA are described.
Ikegami
F
F
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Itagaki
S
S
Ishikawa
T
T
Ongena
G
G
Kuo
Y H
YH
Lambein
F
F
Murakoshi
I
I
D000409:Alanine / Q000031:analogs & derivatives*; D000599:Amino Acids, Diamino; D007887:Fabaceae / Q000378:metabolism*; D007555:Isoxazoles; D009498:Neurotoxins / Q000096:biosynthesis*; D010946:Plants, Medicinal
D000599:Amino Acids, Diamino; D007555:Isoxazoles; D009498:Neurotoxins; C100126:oxalyldiaminopropionic acid; C074507:(isoxazolin-5-on-2-yl)alanine; D000409:Alanine