Intracoronary adenosine and papaverine do not increase myocardial systolic thickening.
OBJECTIVE
The aim was to determine if myocardial systolic thickening increases when coronary flow is augmented by infusing intracoronary vasodilators (adenosine and papaverine).


METHODS
Systolic thickening fraction was measured with pulsed Doppler crystals and sonomicrometer crystals before and during the intracoronary infusion of adenosine and papaverine.


METHODS
Sixteen anaesthetized mongrel dogs were studied.


RESULTS
Intracoronary adenosine did not alter systemic haemodynamics, but did induce a three- to fourfold increase in myocardial blood flow. Intracoronary papaverine caused a slight decrease in systemic arterial pressure and rise in heart rate. Neither intracoronary adenosine nor intracoronary papaverine increased systolic thickening: control thickening fraction (TF%) = 20 (SEM 1)%, adenosine TF% = 18(1)%; control TF% = 22(2)%, papaverine TF% = 20(2)%.


CONCLUSIONS
These experiments do not support the hypothesis that an increase in myocardial blood flow induced by intracoronary vasodilators causes an increase in myocardial systolic function.
Kiesz
R S
RS
Department of Medicine, Milton S Hershey Medical Center, Pennsylvania State College of Medicine, Hershey 17033.
Gehman
J D
JD
Gascho
J A
JA
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology; D003331:Coronary Vessels / Q000187:drug effects; D004285:Dogs; D004452:Echocardiography; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D007261:Infusions, Intra-Arterial; D008297:Male; D010208:Papaverine / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000502:physiology; D013599:Systole / Q000502:physiology
D010208:Papaverine; D000241:Adenosine