title: Distribution of 14C-ochratoxin A and 14C-ochratoxin B in rats: a comparison based on whole-body autoradiography.
abstract: The distribution patterns of ochratoxin A and its nontoxic dechloro-analogue ochratoxin B were studied in rats using whole-body autoradiography. No prominent difference in distribution patterns was found that could explain why the rat is the animal most susceptible to ochratoxin A-induced renal cancer or why ochratoxin B is less toxic than ochratoxin A.
authors.affiliation: Department of Biochemistry and Biotechnology, Royal Institute of Technology, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Breitholtz Emanuelsson
authors.forename: R
authors.initials: R
authors.lastname: Fuchs
authors.forename: K
authors.initials: K
authors.lastname: Hult
authors.forename: L E
authors.initials: LE
authors.lastname: Appelgren
mesh_terms: D000818:Animals; D001345:Autoradiography; D002855:Chromatography, Thin Layer; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D009793:Ochratoxins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D009793:Ochratoxins; C025589:ochratoxin A; C045354:ochratoxin B