Release of ketoprofen from dermal bases in presence of cyclodextrins: effect of the affinity constant determined in semisolid vehicles.
We describe a method to determine the affinity constant values between Ketoprofen and beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin in semisolid vehicles. The method is based on the diffusion of the drug, released from semisolid vehicles, through a lipidic non porous membrane. The affinity constants of Ketoprofen towards cyclodextrins as determined in semisolid media better represent the release of the drug from dermal bases than the corresponding values in aqueous systems.
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Dipartimento di Scienze Farmaceutiche Università di Bologna, Italy.
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D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003505:Cyclodextrins; D005079:Excipients; D007660:Ketoprofen / Q000008:administration & dosage*; D014677:Pharmaceutical Vehicles
D003505:Cyclodextrins; D005079:Excipients; D014677:Pharmaceutical Vehicles; D007660:Ketoprofen