title: Antitoxic properties of a preparation of glutathione S-transferase.
abstract: Pretreatment of rats with a preparation of the cationic form of rat liver cytosolic glutathione S-transferase 1-3 h before injection of a dose of N-nitroso-N-diethylamine equivalent to the LD50 of the drug completely protects the animals against the toxic effects of the drug. The mechanism of the protective action of glutathione S-transferase is discussed.
authors.affiliation: All-Union Research Institute of Biotechnology, Ministry of Medical Industry of the USSR, Moscow.
authors.forename: E V
authors.initials: EV
authors.lastname: Kalinina
authors.forename: V N
authors.initials: VN
authors.lastname: Nechaev
authors.forename: A N
authors.initials: AN
authors.lastname: Saprin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003600:Cytosol / Q000201:enzymology; D004052:Diethylnitrosamine / Q000633:toxicity; D005982:Glutathione Transferase / Q000627:therapeutic use*; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000975:Antioxidants; D004052:Diethylnitrosamine; D005982:Glutathione Transferase