title: Antitumor effect of echitamine chloride on methylcholonthrene induced fibrosarcoma in rats.
abstract: Echitamine chloride a plant alkaloid from Alstonia scholaris has been used to examine the anticancer effects on methylcholanthrene-induced fibrosarcoma. Echitamine chloride dissolved in saline (10 mg/kg body weight) and injected subcutaneously for 20 days in fibrosarcoma rats has exhibited significant regression in tumor growth. The altered activities of plasma and liver transaminases and gamma-glutamyl transpeptidase and lipid peroxidation in fibrosarcoma have been corrected to near normal after echitamine chloride treatment. The decreased liver glutathione content and the lowered activities of glutathione peroxidase, superoxide dismutase and catalase have also been reversed to near normals after echitamine chloride treatment.
authors.affiliation: Department of Biochemistry, University of Madras, India.
authors.forename: P
authors.initials: P
authors.lastname: Kamarajan
authors.forename: N
authors.initials: N
authors.lastname: Sekar
authors.forename: V
authors.initials: V
authors.lastname: Mathuram
authors.forename: S
authors.initials: S
authors.lastname: Govindasamy
mesh_terms: D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005354:Fibrosarcoma / Q000139:chemically induced / Q000188:drug therapy*; D008099:Liver / Q000201:enzymology; D008297:Male; D008748:Methylcholanthrene; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D008748:Methylcholanthrene; C001133:echitamine