Idiopathic acute interstitial nephritis associated with uveitis.
A case of acute interstitial nephritis associated with uveitis is presented, An 18-year-old man developed uveitis followed by renal dysfunction. Moderate renal dysfunction (sCr 3.0 mg/dl), and increased levels of urinary beta 2 microglobulin (over 8,000 micrograms/I) were observed. Renal tissue obtained by open renal biopsy revealed severe infiltration of mononuclear cells in the tubulo-interstitial area. The majority of infiltrating cells were CD4-positive T cells demonstrated by immunoperoxidase staining, suggesting the involvement of T cell-mediated delayed hypersensitivity. Corticosteroid was effective against both uveitis and renal dysfunction. The possible pathogenesis of this syndrome is reviewed from the literature.
Yano
N
N
Department of Internal Medicine, School of Medicine, Tokai University, Isehara, Japan.
Miyazaki
M
M
Endoh
M
M
Kuramoto
T
T
Eguchi
K
K
Yagame
M
M
Nomoto
Y
Y
Sakai
H
H
D000293:Adolescent; D006801:Humans; D006968:Hypersensitivity, Delayed; D008297:Male; D009395:Nephritis, Interstitial / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use; D013577:Syndrome; D013601:T-Lymphocytes / Q000276:immunology; D014605:Uveitis / Q000150:complications* / Q000188:drug therapy / Q000209:etiology
D011239:Prednisolone