DNA single strand-breaks in human lymphocytes after therapy with antirheumatic drugs.
In rheumatic patients the proportion of DNA single strand-breaks in peripheral lymphocytes was investigated after a long-term treatment. The antirheumatic drugs indomethacin, diclofenac, D-penicillamine, auranofin, and chloroquine support the formation of DNA single strand-breaks. The highest rate of DNA single strand-breaks can be seen after treatment with the non-steroidal antirheumatic drugs indomethacin and diclofenac as well as after treatment with the combination of non-steroidal anti-rheumatic drugs with auranofin. In case of treatment with non-steroidal antirheumatic drugs in combination with D-penicillamine the rate of DNA single strand-breaks is lower than by other forms of treatment. The observation support the suspicion of an increased susceptibility to cancer in rheumatic patients after a long-term treatment.
Reitz
M
M
Department of Physiological Chemistry, University of Mainz, Fed. Rep. of Germany,
Lorei
W
W
Lettko
M
M
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D002467:Cell Nucleus / Q000187:drug effects; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000187:drug effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004277:DNA, Single-Stranded