Neuronal and glial cytoskeletons.
Long-awaited evidence for in vivo functions of the major neuronal microtubule associated proteins indicates that they are directly involved in neurite extension. Companion evidence reveals an intrinsic role for glial intermediate filaments in glial cell extension along neurites and for neurofilaments in establishing axonal caliber. New fluorescence and photoactivation experiments require a re-thinking of models of slow axonal transport and of the part the cytoskeleton plays in axonal guidance.
Cleveland
D W
DW
Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205.
Hoffman
P N
PN
D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism* / Q000648:ultrastructure; D009457:Neuroglia / Q000378:metabolism / Q000648:ultrastructure*; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure*
D008869:Microtubule-Associated Proteins