Translocation (3;21)(q26;q22) in secondary leukemia. Report of two cases and literature review.
The authors report two cases of secondary myelodysplasia and acute myeloid leukemia with t(3;21)(q26.3;q22) as the only cytogenetic abnormality in neoplastic bone marrow. This translocation was identified as a rare, recurring, non-random aberration in chronic myeloid leukemia less than five years ago and in secondary acute myeloid leukemia and myelodysplasia in 1990. The known and suspected cases in the literature are reviewed.
Schneider
N R
NR
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072.
Bowman
W P
WP
Frenkel
E P
EP
D000208:Acute Disease; D000293:Adolescent; D002891:Chromosomes, Human, Pair 21; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000150:complications / Q000235:genetics*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*