Inhibition of food intake by omeprazole in the chicken.
Chickens treated with the H+/K+ ATPase inhibitor omeprazole, to inhibit gastric acid secretion, failed to gain weight and showed decreased food intake compared with controls. The gastrin antagonist PD134308 reversed the action of omeprazole on food intake. Since exogenous gastrin decreased food intake, and since omeprazole increased plasma gastrin concentrations, the results suggest that elevated plasma gastrin in chicken exerts a satiety effect.
Campbell
B J
BJ
Physiological Laboratory, University of Liverpool, U.K.
Dimaline
R
R
Dockray
G J
GJ
Hughes
J
J
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D003864:Depression, Chemical; D004435:Eating / Q000187:drug effects*; D005755:Gastrins / Q000097:blood; D007211:Indoles / Q000494:pharmacology; D008536:Meglumine / Q000031:analogs & derivatives / Q000494:pharmacology; D009853:Omeprazole / Q000494:pharmacology*; D011863:Radioimmunoassay; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000187:drug effects; D012528:Satiety Response / Q000187:drug effects
D005755:Gastrins; D007211:Indoles; D011949:Receptors, Cholecystokinin; C065599:PD 134308; D008536:Meglumine; D009853:Omeprazole