title: Evaluation of antibody-bearing liposomal amphotericin B in the treatment of systemic candidiasis in a neutropenic murine model.
abstract: The efficacy of liposomal amphotericin B bearing anticandidal antibodies (LAMB-Ab) was investigated in the treatment of systemic candidiasis in a murine model made neutropenic by an intraperitoneal injection of cyclophosphamide. Treatment with a single dose (0.6 mg amphotericin B kg-1 body weight) of LAMB-Ab resulted in an improved survival of neutropenic mice infected with Candida albicans compared to neutropenic mice treated with identical doses of liposomal amphotericin B or free amphotericin B.
authors.affiliation: Department of Botany and Plant Pathology, Michigan State University, East Lansing 48824.
authors.forename: T
authors.initials: T
authors.lastname: Belay
authors.forename: D R
authors.initials: DR
authors.lastname: Hospenthal
authors.forename: A L
authors.initials: AL
authors.lastname: Rogers
authors.forename: M J
authors.initials: MJ
authors.lastname: Patterson
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000908:Antibodies, Fungal / Q000008:administration & dosage*; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000150:complications / Q000628:therapy*; D004195:Disease Models, Animal; D008081:Liposomes; D051379:Mice; D009503:Neutropenia / Q000150:complications*
chemical_list: D000908:Antibodies, Fungal; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B