Isolation increases a behavioral response to the selective 5-HT 1B agonist CGS 120 66B.
The effect of two serotonergic drugs, CGS 120 66B acting specifically and TFMPP acting preferentially onto 5-HT1B receptors, was compared in preisolated and in pregrouped mice. Two mice put under an inverted beaker attempt to escape. The number of escape attempts of mice preisolated for 7 days was half that of pregrouped mice. In preisolated mice, TFMPP and CGS 120 66B increased the number of escape attempts up to, respectively, 200% and 300% of that of preisolated control mice. In pregrouped mice, CGS 120 66B was nearly inactive and TFMPP exerts a smaller effect. These results suggest that isolation increases the apparent responsiveness to 5-HT1B stimulants.
Frances
H
H
INSERM U.302, Faculté de Médecine Pitié-Salpêtrière, Paris.
Monier
C
C
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D051379:Mice; D010879:Piperazines / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012934:Social Isolation
D010879:Piperazines; D011810:Quinoxalines; D011985:Receptors, Serotonin; C052561:CGS 12066B; C018406:1-(3-trifluoromethylphenyl)piperazine