[Comparative assessment of the effect of adaptation to stress exposure and high altitude hypoxia on heart resistance to reperfusion injury after total ischemia].
Experiments on isolated Wistar rat hearts perfused according to Langendorff showed that adaptation to stress exposure limited the depression of contraction amplitude and contracture and possessed an antiarrhythmic effect in reperfusion. Furthermore, adaptation to stress exposure efficiently limited reperfusion damage to sarcolemma. It was shown that adaptation to hypoxia did not result in any increase in the heart resistance to reperfusion damage following total ischemia. Possible mechanisms of differences in the protective effects of adaptation to stress exposure and hypoxia are discussed.
Meerson
F Z
FZ
Malyshev
I Iu
IIu
Vovk
V I
VI
D000222:Adaptation, Physiological; D000532:Altitude Sickness / Q000503:physiopathology*; D000818:Animals; D006321:Heart / Q000503:physiopathology*; D008297:Male; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000503:physiopathology*; D013312:Stress, Physiological / Q000503:physiopathology*
Sravnitel'naia otsenka vliianiia adaptatsii k stressornym vozdeĭstviiam i vysotnoĭ gipoksii na ustoĭchivost' serdtsa k reperfuzionnomu povrezhdeniiu posle total'noĭ ishemii.