[The anticoagulant and lipolysis-stimulating activity of polysaccharides from marine brown algae].
The search for the compounds inducing release of lipoprotein lipase in the blood flow was made in the series of sulfated polysaccharides of brown sea algae of the Japanese Sea--fucoidanes. The effects of the substances on the blood coagulability were studied. Single intravenous injections of the substances were followed by the combined but independent anticoagulant and lipolysis-stimulating effects. Fucoidane isolated from Pelvetia wrightii possessed the greatest lipolysis-stimulating activity along with a weak anticoagulant effect. The degree of the pharmacological effects of the studied compounds did not depend on the degree of sulfation of macromolecules of the polysaccharides. In contrast to heparin fucoidanes exhibited the maximum effect on lipolysis later, 120-180 minutes after the intravenous injection.
Rozkin
M Ia
MIa
Levina
M N
MN
Efimov
V S
VS
Usov
A I
AI
D000818:Animals; D000925:Anticoagulants / Q000302:isolation & purification / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D000459:Phaeophyceae; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D013268:Stimulation, Chemical; D013916:Thrombelastography; D013997:Time Factors
D000925:Anticoagulants; D011134:Polysaccharides; D006493:Heparin; C007789:fucoidan
Antikoguliantnaia i stimuliruiushchaia lipoliz aktivnost' polisakharidov iz burykh morskikh vodorosleĭ.