Hypoxia, PAF, and necrotizing enterocolitis.
Necrotizing enterocolitis (NEC) is an important neonatal disease with a high mortality rate. The pathophysiology is unclear but epidemiologic studies suggest that hypoxia and infection are important risk factors. In this review we discuss the effect of hypoxia and platelet-activating factor (PAF) on intestinal blood flow and intestinal necrosis, and implicate PAF as an important mediator in hypoxia-induced intestinal injury. Finally we provide evidence that PAF may be important in neonatal NEC.
Caplan
M S
MS
Department of Pediatrics, Children's Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614.
Sun
X M
XM
Hsueh
W
W
D000818:Animals; D001381:Azepines / Q000627:therapeutic use; D004760:Enterocolitis / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D007422:Intestines / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D009336:Necrosis; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D011806:Quinolinium Compounds / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use
D001381:Azepines; D010972:Platelet Activating Factor; D011806:Quinolinium Compounds; D014230:Triazoles; C050531:SRI 63-441; C052518:WEB 2086