Synthesis and antiaggregatory activity of antiflammin related peptides.
The peptide H-Lys-Val-Leu-Asp-OH (KVLD), derived from antiflammins, and its analog H-Lys-Val-Asp-Leu-OH (KVDL) were prepared by solution synthesis. KVLD does not inhibit platelet aggregation in contrast to the results recently published.
Marastoni
M
M
Dipartimento Scienze Farmaceutiche Università di Ferrara, Italy.
Scaranari
V
V
Salvadori
S
S
Tomatis
R
R
Spisani
S
S
Traniello
S
S
D000595:Amino Acid Sequence; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
D009842:Oligopeptides; D010975:Platelet Aggregation Inhibitors; C074440:lysyl-valyl-leucyl-aspartic acid; C074441:lysyl-valyl-aspartyl-leucine; D005340:Fibrinogen