title: A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100.
abstract: A new trimethoprim resistance determinant, designated dhfrX, was identified in the In7 integron of pDGO100. The sequence of the dhfrX dihydrofolate reductase is up to 28% identical to the sequences of several known dihydrofolate reductase proteins. The dhfrX gene is adjacent to the second 3'-conserved segment of the In7 integron, but the first 77 bases of this segment are not present.
authors.affiliation: School of Biological Sciences, Macquarie University, Sydney, NSW, Australia.
authors.forename: Y
authors.initials: Y
authors.lastname: Parsons
authors.forename: R M
authors.initials: RM
authors.lastname: Hall
authors.forename: H W
authors.initials: HW
authors.lastname: Stokes
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D015183:Restriction Mapping; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics; D014158:Transcription, Genetic; D014296:Trimethoprim Resistance / Q000235:genetics*
chemical_list: D013762:Tetrahydrofolate Dehydrogenase