title: Effect of zidovudine on cerebrospinal fluid in patients with HIV infection and acute neurological disease.
abstract: Two cases of HIV infection associated with neurological complications are described. The patients had been followed with repeated cerebrospinal fluid (CSF) analyses 1-3 years before the neurological disease and 5 months after zidovudine treatment. CSF mononuclear cell count and the AIDS predictors beta 2-microglobulin and neopterin decreased in CSF after treatment and were lower or at the level seen 1-3 years before treatment. The results suggest that zidovudine has a suppressive effect on the HIV infection in CNS at least for 5 months, even when low zidovudine doses (500 mg daily) were used.
authors.affiliation: Department of Infectious Diseases, University of Göteborg, Ostra Hospital, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Hagberg
authors.forename: M
authors.initials: M
authors.lastname: Andersson
authors.forename: F
authors.initials: F
authors.lastname: Chiodi
authors.forename: D
authors.initials: D
authors.lastname: Fuchs
authors.forename: B
authors.initials: B
authors.lastname: Svennerholm
authors.forename: H
authors.initials: H
authors.lastname: Wachter
authors.forename: G
authors.initials: G
authors.lastname: Norkrans
mesh_terms: D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D000208:Acute Disease; D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid; D005260:Female; D015658:HIV Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D006801:Humans; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D015215:Zidovudine / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid
chemical_list: D001613:beta 2-Microglobulin; D001708:Biopterins; D015215:Zidovudine; D019798:Neopterin