Possible mechanisms underlying the special vulnerability of dopaminergic neurons.
Endogenous or exogenous agents may account for the special vulnerability of dopaminergic neutrons. The present paper deals primarily with the possible role of toxic quinoid metabolites of catechols formed by autoxidation. The study of 5-S-cysteinyl adducts of these metabolites may provide clues to underlying mechanisms. In addition these adducts may serve as markers of Parkinson's disease.
Carlsson
A
A
Department of Pharmacology, University of Göteborg, Sweden.
Fornstedt
B
B
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D002470:Cell Survival / Q000502:physiology; D004298:Dopamine / Q000031:analogs & derivatives / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000503:physiopathology*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*
D011954:Receptors, Dopamine; C047408:5-S-cysteinyldopamine; D004298:Dopamine