Thalamic short-term plasticity in the auditory system: associative returning of receptive fields in the ventral medial geniculate body.
The effects of classical conditioning on frequency receptive fields (RFs) in the ventral, tonotopic part of the guinea pig (Cavia porcellus) medial geniculate ventral body (MGv) during cardiac conditioning to a single tone frequency were studied. Associative frequency-specific plasticity, in which the RF was returned to the frequency of the conditioned stimulus (CS), developed if the CS frequency was within 0.125 octave of the pretraining best frequency. Otherwise, a general increase across the RF developed. Sensitization training also produced general increased responses. The frequency-specific plasticity was short-term and observed only immediately after training, whereas the general effects were maintained. These results suggest that frequency-specific RF plasticity in the MGv may be a substrate of short-term mnemonic processes that could participate in long-term storage of information and modification of the representation of the CS at the auditory cortex.
Edeline
J M
JM
Center for the Neurobiology of Learning and Memory, Bonney Center, University of California, Irvine 92717.
Weinberger
N M
NM
D000818:Animals; D001143:Arousal / Q000502:physiology; D001245:Association Learning / Q000502:physiology*; D001303:Auditory Cortex / Q000502:physiology*; D001306:Auditory Pathways / Q000502:physiology; D001309:Auditory Threshold / Q000502:physiology; D001931:Brain Mapping; D003214:Conditioning, Classical / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005829:Geniculate Bodies / Q000502:physiology*; D006168:Guinea Pigs; D006339:Heart Rate / Q000502:physiology; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010897:Pitch Discrimination / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology; D013787:Thalamic Nuclei / Q000502:physiology*