title: Treatment of high-output gastric fistulas with omeprazole.
abstract: Two patients with high-output gastrocutaneous fistulas were treated with total parenteral nutrition and gastric antisecretory drugs. IV administration of omeprazole decreased acid output in one patient in a rapid and significant way, resulting in the spontaneous healing of the fistula after eight days of treatment. In the second patient, omeprazole caused a marked reduction in the acidity of the fluid in the fistula, which also closed without surgical operation. The long-standing decrease in acid output induced by intravenous omeprazole may be very useful for promoting spontaneous closure of high-output gastrocutaneous fistula.
authors.affiliation: Department of Surgery, Academic Hospital, Free University Brussels, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Deruyter
authors.forename: M
authors.initials: M
authors.lastname: Van Blerk
authors.forename: G B
authors.initials: GB
authors.lastname: Cadière
authors.forename: J
authors.initials: J
authors.lastname: De Graef
authors.forename: G
authors.initials: G
authors.lastname: Willems
mesh_terms: D005747:Gastric Fistula / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D012008:Recurrence
chemical_list: D009853:Omeprazole