A chondroitin-sulfate chain is located on serine-10 of the urinary trypsin inhibitor.
1. The glycopeptide carrying the glycosaminoglycan chain of the urinary trypsin inhibitor (immunologically and structurally related to inter-alpha-trypsin inhibitor) was isolated. 2. The data from amino acid composition and part sequencing of this glycopeptide unambiguously demonstrate that the glycosaminoglycan is covalently linked to serine-10 of the peptide chain of UTI.
Chirat
F
F
Laboratoire de Biochimie, Faculté de Pharmacie, Lille, France.
Balduyck
M
M
Mizon
C
C
Laroui
S
S
Sautiere
P
P
Mizon
J
J
D000595:Amino Acid Sequence; D000818:Animals; D002809:Chondroitin Sulfates / Q000032:analysis*; D006020:Glycopeptides / Q000737:chemistry* / Q000302:isolation & purification; D006023:Glycoproteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D012694:Serine / Q000737:chemistry; D012697:Serine Endopeptidases / Q000378:metabolism; D014361:Trypsin Inhibitors / Q000737:chemistry*
D006020:Glycopeptides; D006023:Glycoproteins; D014361:Trypsin Inhibitors; D012694:Serine; D002809:Chondroitin Sulfates; D012697:Serine Endopeptidases; C028344:glutamyl endopeptidase; C028665:urinastatin