[The characteristics of the embryotoxic action of kalipsol].
The effect of calipsol on the course of pregnancy and the embryonal development in albino rats was studied. It was found that single injections of the drug in a dose of 200 mg/kg on the 7th or 8th day of pregnancy induced no disorders in the pregnancy course and the embryonal development. At the administration in a dose of 40.0 mg/kg on the 11th, 13th, 15th days of pregnancy calipsol was shown to exert a marked embryolethal action and at the administration on the 7th, 9th, 11th days of pregnancy in doses of 20 and 40 mg/kg increased the number of fetuses with hemorrhages into the internal organs.
Bandazhevskiĭ
Iu I
IuI
Shimanovich
A I
AI
D000818:Animals; D004305:Dose-Response Relationship, Drug; D020964:Embryo Loss / Q000139:chemically induced; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D007649:Ketamine / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D007649:Ketamine
Osobennosti émbriotoksicheskogo deĭstviia kalipsola.