Rat liver amino acid balances after the administration of an oral protein load.
The hepatic balances of amino acids, ammonia and urea have been measured in rats for three hours after receiving a protein load. The liver took up practically all of the portal ammonium. Alanine was retained to a large extent during all three hours. Other portal amino acids, mainly essential amino acids, were largely retained in about one hour after the gavage, to be released in a similar proportion thereafter. The other amino acids were also retained and then released, but to a lower extent. These amino acids were used in part by the liver for the synthesis and release of urea, which appearance in hepatic vein peaked at two hours after the protein administration.
Casado
J
J
Departament de Bioquímica i Fisiologia, Universitat de Barcelona, Spain.
Fernández-López
J A
JA
Esteve
M
M
Rafecas
I
I
Argilés
J M
JM
Alemany
M
M
D000284:Administration, Oral; D000596:Amino Acids / Q000097:blood*; D000641:Ammonia / Q000378:metabolism; D000818:Animals; D004044:Dietary Proteins / Q000493:pharmacokinetics; D004764:Enterohepatic Circulation; D008099:Liver / Q000378:metabolism*; D008297:Male; D011506:Proteins / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000378:metabolism
D000596:Amino Acids; D004044:Dietary Proteins; D011506:Proteins; D000641:Ammonia; D014508:Urea