[Determination of peanut agglutinin receptor in the diagnosis of nasal neoplasms].
Formalin-fixed paraffin-embedded biopsy specimens of normal nasal mucosae, nasal polyps, nasal inverted papillomas and nasal papillary adenocarcinomas were tested by biotinylated peanut agglutinin (PNA) for the demonstration of PNA receptor. The normal nasal mucosae showed a total absence of epithelial staining. In nasal polyps, PNA bound to supranuclear portion of cells (68 cases, 85%) but not to apical cytoplasm. In case of inverted papilloma, PNA showed a positive reactivity in the plasmatic membranes of 47 cases (78.33%) and in the perinuclear cytoplasm of 52 cases (86.67%), with an increase in PNA positively related to the degree of dysplasia. In papillomatous adenocarcinoma, PNA binding was present in the apical cytoplasm of 37 cases (92.5%) with a linear pattern and in the supranuclear portion of 3 cases (7.5%). It may suggest that the quantity and distribution of PNA receptor in the cells of nasal mucosae are related to their differentiation and transformation.
Huang
H
H
Changhai Hospital, Shanghai.
D000231:Adenocarcinoma, Papillary / Q000175:diagnosis; D006801:Humans; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology; D009298:Nasal Polyps / Q000175:diagnosis; D009669:Nose Neoplasms / Q000175:diagnosis*; D010212:Papilloma / Q000175:diagnosis; D011975:Receptors, Mitogen / Q000032:analysis*
D011975:Receptors, Mitogen; C038223:peanut agglutinin receptor