Interleukin-1 beta regulation of islet and thyroid autoimmunity in the BB rat.
Daily injections of high dose human recombinant interleukin-1 beta (IL-1 beta) accelerated the onset of both insulin-dependent diabetes mellitus and lymphocytic thyroiditis in genetically prone BB rats. In diabetes-resistant BB rats, high dose IL-1 beta failed to induce diabetes. Additionally, the presence of neutralizing IL-1 beta antibodies in these rats strongly correlated with inhibition of lymphocytic thyroiditis. Since low dose IL-1 beta protects diabetes-prone rats from IDDM, we conclude that IL-1 beta is a potent modulator of autoimmune diabetes and thyroid disease in genetically susceptible rats.
Vertrees
S
S
University of Washington, Department of Medicine, Seattle 98195.
Wilson
C A
CA
Ubungen
R
R
Wilson
D
D
Baskin
D G
DG
Toivola
B
B
Jacobs
C
C
Boiani
N
N
Baker
P
P
Lernmark
A
A
D000311:Adrenal Glands / Q000033:anatomy & histology; D000367:Age Factors; D000818:Animals; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D005856:Germ-Free Life; D007274:Injections, Intraperitoneal; D007375:Interleukin-1 / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000276:immunology*; D007668:Kidney / Q000033:anatomy & histology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000033:anatomy & histology; D051381:Rats; D011913:Rats, Inbred BB; D011994:Recombinant Proteins / Q000276:immunology; D013154:Spleen / Q000033:anatomy & histology; D013950:Thymus Gland / Q000033:anatomy & histology; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000139:chemically induced / Q000276:immunology; D013974:Thyroxine / Q000097:blood
D007375:Interleukin-1; D011994:Recombinant Proteins; D013974:Thyroxine