Neuroanatomical characterization of inferior collicular seizure genesis: 2-deoxyglucose and stimulation mapping.
Previous work has demonstrated that the cortical sub-division of the inferior colliculus is capable of seizure genesis, so the present studies delineated the neuroanatomical extent of this seizure genesis using two mapping techniques, [14C]2-deoxyglucose (2-DG) uptake and electrical stimulation. When 4 inferior collicular seizures were elicited over a 5 min period, the stimulated side of the brain showed highly selective increases in the [14C]2-DG uptake in comparison to the unstimulated side. Although the substantial change in [14C]2-DG uptake occurred over the entire inferior collicular cortex, electrical stimulation mapping delineated a specific area capable of seizure genesis within the inferior collicular cortex. The electrical stimulation also identified a number of regions that would support electrically dependent seizure behaviors: the cuneiform nucleus, the ventrolateral inferior colliculus, portions of the dorsal central gray, and the peripeduncular nucleus. In concert, marked unilateral increases in [14C]2-DG uptake were found on the stimulated side in the peripeduncular/substantia nigra lateralis area, the medial geniculate and a specific region of the dorsal central gray. These studies verify the asymmetric nature of inferior collicular seizure genesis, identify areas of seizure modulation, and delineate a region in the inferior collicular cortex that modulates sensory-motor integration.
McCown
T J
TJ
Department of Anatomy, University of North Carolina, Chapel Hill 27599-7250.
Duncan
G E
GE
Breese
G R
GR
D000818:Animals; D001345:Autoradiography; D001692:Biological Transport; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology* / Q000503:physiopathology; D001931:Brain Mapping; D002250:Carbon Radioisotopes; D003847:Deoxyglucose / Q000378:metabolism*; D004558:Electric Stimulation; D007245:Inferior Colliculi / Q000033:anatomy & histology / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*
D002250:Carbon Radioisotopes; D003847:Deoxyglucose