Four compartment mammillary model applied to the pharmacokinetics of a spiroarsorane administered orally to rabbits.
Rekik et al. dealt with the pharmacokinetics of two spiroarsoranes molecules administered intravenously or orally to rabbits. For the intravenous study they used an open two-compartment model. For the oral study they admitted that they were unable to fit the data to a model. In this paper the plasma concentration profile of molecule 2 after oral administration using a four mammillary open compartment model is described. This type of model (which requires a fourth degree equation) has been previously described. Here it is applied to a concrete situation.
de Biasi
J
J
UFR de Mathématiques, Université Paul Sabatier, Toulouse, France.
Rekik
L
L
D000284:Administration, Oral; D000818:Animals; D001147:Arsanilic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D001825:Body Fluid Compartments / Q000502:physiology*; D016018:Least-Squares Analysis; D008432:Mathematical Computing; D008954:Models, Biological; D011817:Rabbits; D013141:Spiro Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*
D013141:Spiro Compounds; C059856:octamethyl-2,2,3,3,7,7,8,8-arsa-5-(4-hydroxy)-3-acetamidophenyl-5-spiro-(4,4)-nonane; D001147:Arsanilic Acid