[Effect of ethacrynic acid on the course of cytotoxic glomerulonephritis].
Ethacrynic acid (10 mg/kg subcutaneously 15 days) significantly facilitated the experimental glomerulonephritis in rats. The efficacy of diuretic was confirmed by the improvement of the functional characteristics (the degree of proteinuria, the plasma contents of protein and urea, the creatinine excretion), and by the results of the histological investigation, especially at the second phase of the pathological process.
Averev
Ia F
IaF
Talalaev
S V
SV
Oberemok
A V
AV
D000818:Animals; D003404:Creatinine / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D004976:Ethacrynic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000188:drug therapy*; D007668:Kidney / Q000503:physiopathology; D008297:Male; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine
D012964:Sodium; D003404:Creatinine; D004976:Ethacrynic Acid; D011188:Potassium
Vliianie étakrinovoĭ kisloty na techenie tsitoksicheskogo glomerulonefrita.