Embryopathic action of N-nitrosomethylurea in the male mouse manifest in the first generation.
Offspring from paternal mice treated with N.M.U. (20 mg/kg/i.p.) incurred an increased incidence of pre and post-weaning mortality. Those conceived immediately after treatment presented a high incidence of tumor bearing animals, double that in the concurrent untreated controls. These events are thought to reflect chemical damage to spermatozoa present at the time of treatment. The relatively high incidence of offspring presenting tumours and which were conceived in later weeks suggest impairment of earlier germ cells. Male offspring conceived in weeks 1 to 4 post-treatment produced a significant incidence of T. B. A.s (p less than 0.01, binomial analysis) and developed 5 types of neoplasia not encountered in male controls; the corresponding females presented 9 kinds of tumour which had no counterpart in the control females. Two features presented a significant change from the control (p less than 0.001, binomial analysis): firstly, the number of reticuloses involving all offspring and secondly the incidence of tumours of vascular origin in female offspring overall.
Hemsworth
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Life Science Laboratory, Teesside Polytechnic, Middlesbrough, Cleveland, U.K.
D000818:Animals; D004622:Embryo, Mammalian / Q000002:abnormalities*; D005854:Germ Cells / Q000187:drug effects*; D008297:Male; D008770:Methylnitrosourea / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000151:congenital / Q000473:pathology; D012307:Risk Factors; D013094:Spermatozoa / Q000187:drug effects; D013997:Time Factors
D008770:Methylnitrosourea