Anti-tubercular treatment in patients with hepatitis.
Sixty seven patients with coexistent tuberculosis and hepatitis were given a 3 drug regimen of streptomycin (SM), isonicotinic acid hydrazide (INH) and ethambutol (ETB) and observed for a period of 15 days. Total bilirubin as well as SGPT were repeated weekly and these showed a significant drop in a majority of patients when observed over this period. No patient developed any signs of fulminant hepatic failure. We conclude that a regimen of SM, INH and ETB can be given to patients who suffer from combined pathologies of pulmonary tuberculosis and active hepatitis without incurring the danger of increasing hepatocellular dysfunction/damage.
Deshpande
D V
DV
TNM College and BYL Nair Ch Hospital, Bombay.
Nachne
D
D
Koyande
D
D
Rodriques
C J
CJ
D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000627:therapeutic use*; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000150:complications*; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D013307:Streptomycin / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000150:complications* / Q000188:drug therapy*
D004977:Ethambutol; D000410:Alanine Transaminase; D001663:Bilirubin; D007538:Isoniazid; D013307:Streptomycin