Cytosolic calcium ion regulation in cultured endothelial cells.
Mechanisms involved in Ca2+ homeostasis and stimulus-secretion coupling in cultured endothelial cells in response to humoral and physical stimuli include passive leak, activation of ion channels, and chemical second messengers. Calcium entry is controlled by receptor activation, passive leak, and mechanical stretch. The rate at which Ca2+ enters the cell through these pathways is dependent on the transmembrane potential which governs the electrochemical gradient for Ca2+ and which is set by participation of various K channels.
Laskey
R E
RE
Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, FL 33101.
Adams
D J
DJ
Purkerson
S
S
van Breemen
C
C
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D003600:Cytosol / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D006801:Humans
D002118:Calcium