[L-thyroxine and L-triiodothyronine in the cerebral tissues of the adult rat. Effect of hypothyroidism].
The L-thyroxine and L-triiodothyronine concentrations in several brain areas (cerebral cortex, brain stem, hypothalamus, total brain and hypophysis) in normal and hypothyroid rats have been studied. Results show that L-thyroxine values at tissue level are inferior in the hypothyroid group, although non-significant with respect to the control group, whereas L-triiodothyronine presents values similar to the hypothyroid group and its control in all the brain regions studied with the exception of hypophysis. These results show that in hypothyroid situations exist a compensatory mechanism for maintaining the adequate L-triiodothyronine levels in several brain areas, although the serum levels are strongly decreased in hypothyroid animals.
Serrano-Lozano
A
A
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Málaga, España.
Morata
P
P
Montiel
M
M
Pérez-Aguilar
J P
JP
Morell
M
M
D000818:Animals; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D007037:Hypothyroidism / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy; D013974:Thyroxine / Q000032:analysis*; D014284:Triiodothyronine / Q000032:analysis*
D014284:Triiodothyronine; D013974:Thyroxine
L-tiroxina y L-triiodotironina en tejidos cerebrales de rata adulta. Afectación ante un estado hipotiroideo.