title: The risk factors of median sternotomy infection: a current review.
abstract: Sternal sepsis following median sternotomy is an infrequent yet devastating complication of cardiac surgery, leading to prolonged hospitalization, increased hospital expense, and a high associated morbidity and mortality. The development of sternotomy infection is multifactorial. Numerous prospective and retrospective studies have pointed to a multitude of clinical and perioperative variables as being causative, with as many other studies presenting evidence of the contrary. This has led to confusion about which clinical variables should be modified so as to minimize the individual patient's risk for developing this severe complication. Other less obvious factors also come into play. Malnutrition, whether overt or subclinical, is not uncommon in cardiac patients. Immune competency is affected by operative trauma, as well as a variety of perioperative factors including underlying nutritional status, transfusion, cardiopulmonary bypass, and anesthesia. This creates a complex milieu for the development of postoperative infection. In this review, the multiple risk factors of median sternotomy infection are studied and treatment options briefly discussed.
authors.affiliation: Department of Surgery, Jewish Hospital of Cincinnati, Ohio.
authors.forename: K S
authors.initials: KS
authors.lastname: Ulicny
authors.forename: L F
authors.initials: LF
authors.lastname: Hiratzka
mesh_terms: D006348:Cardiac Surgical Procedures; D006801:Humans; D007165:Immunosuppression Therapy; D009752:Nutritional Status; D012307:Risk Factors; D013249:Sternum / Q000601:surgery*; D013530:Surgical Wound Infection / Q000209:etiology*; D065227:Transfusion Reaction