Protection against the lethal effect and arthritogenic capacity of Yersinia enterocolitica serovar O:3 for mice.
Protection against the intravenous lethal effect of Yersinia enterocolitica serovar O:3 for mice can be achieved by oral immunization with bacteria expressing the O:3 lipopolysaccharide (LPS). Under similar experimental conditions, Ca(2+)-dependent cells are more protective than their Ca(2+)-independent counterparts, live vaccines are more efficacious than killed ones, and parenteral immunization is more efficient than the oral route. Antibodies induced by enzyme-treated LPS from an O:3 strain are able to mediate protection against challenge with one homologous strain, but they do not prevent induction of arthritis.
de los Toyos
J R
JR
Area de Microbiología, Facultad de Medicina, Universidad de Oviedo, Spain.
Díaz
R
R
Hardisson
C
C
D000284:Administration, Oral; D000818:Animals; D001170:Arthritis, Infectious / Q000209:etiology / Q000517:prevention & control*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D007116:Immunization, Passive; D007274:Injections, Intraperitoneal; D008070:Lipopolysaccharides / Q000276:immunology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000627:therapeutic use; D015164:Vaccines, Inactivated / Q000627:therapeutic use; D015009:Yersinia Infections / Q000150:complications / Q000401:mortality / Q000517:prevention & control*; D015008:Yersinia enterocolitica / Q000472:pathogenicity*
D008070:Lipopolysaccharides; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated