Human eccrine sweat gland. Expression of neuroglandular antigens and coexpression of intermediate filaments.
Acrosyringium, duct and secretory epithelium as well as myoepithelial cells of human eccrine sweat glands have been characterized by different immunostaining patterns with mono- and polyclonal antibodies to a wide spectrum of tissue antigens. Using monoclonal antibodies to neuron-specific enolase (NSE) and melanoma-associated antigens (LS 59, HMB-45, NKI/C-3) the expression of neuroectodermal antigens in secretory coils was demonstrated. Myoepithelial cells were double-stained with polyclonal vimentin and monoclonal CAM 5.2 (against keratins nos. 8, 18, 19) antibodies.
Wollina
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Department of Dermatology, University of Köln, F.R.G.
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D001706:Biopsy; D002462:Cell Membrane / Q000737:chemistry / Q000648:ultrastructure; D003238:Connective Tissue / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis*; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis*; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D013545:Sweat Glands / Q000737:chemistry* / Q000502:physiology / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D007381:Intermediate Filament Proteins; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase