Formation and removal of DNA adducts in liver of rats treated with hepatocarcinogens 2-aminofluorene or 2-acetylaminofluorene.
The level of adducts in DNA of rats treated with 2-aminofluorene (2-AF) and 2-acetylaminofluorene (2-AAF) was compared at the times from 1 h till 28 days after injection. The highest amount of DNA adducts was observed 12 h after treatment with 2-AF and 24 h after treatment with 2-AAF, and reached values of about 18 and 21 fmol per micrograms DNA, respectively. Participation of the nonacetylated form, dG-C8-AF, in the total amount of DNA adducts was only slightly greater in rats treated with 2-AF then in those treated with 2-AAF.
Widłak
P
P
Department of Tumor Biology, Institute of Oncology, Gliwice, Poland.
Rzeszowska-Wolny
J
J
D015073:2-Acetylaminofluorene / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens; D004247:DNA / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D005449:Fluorenes / Q000633:toxicity*; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009153:Mutagens; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D005449:Fluorenes; D009153:Mutagens; C012177:2-aminofluorene; D004247:DNA; D015073:2-Acetylaminofluorene