Infant heart transplantation 1991.
Between November 1985 and June 1991, there were 118 orthotopic heart transplantations performed on 117 infants less than 1 year old. Indications for transplantation were dominated by complex congenital heart disease (92%). Weight ratio between donor and recipient was 1.75 +/- 0.72 and ischemic time was 255 +/- 121 minutes. Early mortality was 10.2% and 5-year actuarial survival was 79%. Rejection diagnoses have been achieved mainly with noninvasive techniques. The immunosuppression regimen was comprised of daily cyclosporine A and azathioprine. Steroids were used only for rejection treatment. These results are encouraging and comparable to those of adult transplantation. The shortage of organ donors remains a major problem in pediatric transplantation.
Bouchart
F
F
Loma Linda University Medical Center, Department of Surgery, California.
Gundry
S R
SR
Bailey
L L
LL
D000206:Actuarial Analysis; D002140:California; D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000187:drug effects; D006085:Graft Survival / Q000187:drug effects; D006330:Heart Defects, Congenital / Q000401:mortality / Q000601:surgery*; D016027:Heart Transplantation / Q000706:statistics & numerical data*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D011183:Postoperative Complications / Q000401:mortality*; D015996:Survival Rate; D014019:Tissue Donors / Q000706:statistics & numerical data
D008775:Methylprednisolone