title: Reproducibility of P3.
abstract: The P3 event-related potential has been widely employed in both clinical and research investigations. In the present study, P3 latency and amplitude intersession reliability were evaluated in 4 sessions over an average of 33 days in 24 healthy adults using the P3 tonal oddball paradigm. Mean group latencies ranged from 302-305 ms and mean amplitudes ranged from 7.75-8.87 microV. No significant group differences were found across sessions for latency or amplitude. Intrasubject variability was large; the 95% confidence interval for the difference between the means of two combined sessions was +/- 20 ms for latency and +/- 4.63 microV for amplitude. The results suggest that P3 latency and amplitude are reliable and reproducible over weeks for groups, but have greater variability for individuals.
authors.affiliation: Department of Neurology Medical College of Georgia, Augusta 30912-3275.
authors.forename: E Y
authors.initials: EY
authors.lastname: Zamrini
authors.forename: K J
authors.initials: KJ
authors.lastname: Meador
authors.forename: W O
authors.initials: WO
authors.lastname: Thompson
authors.forename: G P
authors.initials: GP
authors.lastname: Lee
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004585:Electrooculography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values