Effects of cholinomimetics and cholinolytics in a despair test in mice.
Cholinomimetics prolonged, while cholinolytics shortened the immobility time ("despair reaction") in a forced swimming test. It is concluded that this behavioral test is useful in studies on the central cholinergic system in mice.
Mrowiec
J
J
Department of Pharmacology, Silesian Medical Academy, Medical Faculty in Zabrze, Poland.
Plech
A
A
Brus
R
R
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000523:psychology*; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D010276:Parasympatholytics / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology*; D013550:Swimming
D010276:Parasympatholytics; D010277:Parasympathomimetics