title: [Chronic active or aggressive hepatitis and liver cirrhosis with copper accumulation in a Dobermann. Case report].
abstract: Clinical signs, haematological and biochemical abnormalities as well as the pathomorphological and electronmicroscopic findings observed in a 7 1/2 year old spayed female Dobermann suffering from chronic active hepatitis and cirrhosis are described. During almost the whole period of observation the clinical signs were nonspecific. The laboratory findings indicated a progressive liver disease. Gross findings revealed an atrophic cirrhosis. Histopathologically characteristic features of chronic active hepatitis were also seen together with a moderate copper accumulation localized in the periphery of the hepatic lobules. There was no evidence of cholestasis.
authors.affiliation: Klinik und Poliklinik für kleine Haustiere, Freien Universität Berlin.
authors.forename: F E
authors.initials: FE
authors.lastname: Röcken
authors.forename: H B
authors.initials: HB
authors.lastname: Nothelfer
authors.forename: G
authors.initials: G
authors.lastname: Janssen
mesh_terms: D000818:Animals; D003300:Copper / Q000032:analysis / Q000378:metabolism*; D004283:Dog Diseases / Q000097:blood / Q000473:pathology*; D004285:Dogs; D005260:Female; D006521:Hepatitis, Chronic / Q000097:blood / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008099:Liver / Q000737:chemistry* / Q000473:pathology / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000662:veterinary*
chemical_list: D003300:Copper
vernacular_title: Chronisch aktive oder aggressive Hepatitis (CAH) und Leberzirrhose mit Kupferspeicherung beim Dobermann. Fallbericht.