title: [Experimental anti-arrhythmic effects of zhigancao (prepared licorice) injection].
abstract: Zhigancao injection can antagonise the arrhythmia induced by chloroform, adrenaline, aconitine, strophanthine K and barium chloride, slow the heart rate, prolong P-R and Q-T intervals and antagonise the positive chronotropic response induced by isoprenaline. The LD50 of zhigancao injection is 41.2g/kg in nice by intraperitoneal.
authors.affiliation: Longhua Hospital, Shanghai College of Traditional Chinese Medicine.
authors.forename: R
authors.initials: R
authors.lastname: Chen
authors.forename: C
authors.initials: C
authors.lastname: Yuan
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D005260:Female; D006035:Glycyrrhiza; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D007267:Injections; D008297:Male; D051379:Mice; D010946:Plants, Medicinal; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014693:Ventricular Fibrillation / Q000517:prevention & control
chemical_list: D000889:Anti-Arrhythmia Agents; D004365:Drugs, Chinese Herbal