title: Abnormalities in the glycosylation of IgG in spouses of patients with rheumatoid arthritis. A family study.
abstract: Forty-seven members of eight families with a rheumatoid proband were analysed for abnormal glycosylation of IgG. The results (%G(o) which is the percentage of oligosaccharide chains lacking galactose) were corrected for age and expressed as SD units about the mean for the normal population. Seven of 8 probands, 3/8 spouses, 3/5 RA relatives and 4/26 non-RA relatives had %G(o) values greater than 1SD above the age corrected mean for the normal control population (P less than 0.001, less than 0.01, less than 0.005 and greater than 0.5 respectively). A further 13 spouse pairs were studied. Ten of 13 probands and 8/13 spouses had %G(o) values greater than 1SD above the mean (P less than 0.001 and less than 0.001 respectively). Thus in total, a strikingly high number of unaffected spouses had high %G(o) values (11/21). IgM, IgA and IgG rheumatoid factors were studied. While RA patients' sera showed a correlation between IgM and IgA rheumatoid factors and %G(o), (IgM, r = 0.41 0.05 greater than P greater than 0.02, IgA, r = 0.36, P = 0.05), no correlation between IgG RF and %G(o) was noted in the RA patients. No correlation was found between any of the RF classes and %G(o) in spouses and non-RA relatives.
authors.affiliation: Department of Immunology, University College, Middlesex Hospital School of Medicine, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Sumar
authors.forename: C B
authors.initials: CB
authors.lastname: Colaço
authors.forename: K B
authors.initials: KB
authors.lastname: Bodman
authors.forename: R
authors.initials: R
authors.lastname: Parekh
authors.forename: P
authors.initials: P
authors.lastname: Williams
authors.forename: R
authors.initials: R
authors.lastname: Dwek
authors.forename: T
authors.initials: T
authors.lastname: Rademacher
authors.forename: D A
authors.initials: DA
authors.lastname: Isenberg
authors.forename: A
authors.initials: A
authors.lastname: Soltys
authors.forename: F C
authors.initials: FC
authors.lastname: Hay
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology*; D005190:Family; D005260:Female; D006031:Glycosylation; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000737:chemistry / Q000378:metabolism*; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D012217:Rheumatoid Factor / Q000032:analysis
chemical_list: D006684:HLA-DR Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor