Comparison of anti-lipid peroxidative effects of the underground parts of Notopterygium incisum and N. forbesii in mice.
Intraperitoneal administration of CCl4 to mice led to significant increases of thiobarbituric acid-reactive substances (TBA-RS), free malondialdehyde (MDA), lipid conjugated dienes and fluorescent lipid peroxidation products in the liver. However, subchronic pretreatment with oral doses of the MeOH extract of either the underground part of Notopterygium incisum or that of N. forbesii appreciably suppressed the formation of CCl4-induced lipid peroxidation products. The suppressing potency was more remarkable in the former.
Yang
X W
XW
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University.
Gu
Z M
ZM
Wang
B X
BX
Hattori
M
M
Namba
T
T
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D013858:Thiobarbiturates / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D013858:Thiobarbiturates; C067415:qiang-huo; D008315:Malondialdehyde; D002251:Carbon Tetrachloride; C029684:thiobarbituric acid