title: [A rare case of allergic granulomatous angitis (Churg Strauss syndrome) with positive anti-glomerular basement membrane (GBM) antibody in serum].
abstract: A 33-year-old man with a 6-month history of rhinitis and bronchial asthma was referred to our hospital with polyarthralgia, severe anemia, hypoxemia, mononeuropathy multiplex, and renal insufficiency with hematuria. Marked eosinophilia was observed in his sputum, peripheral blood, and bronchoalveolar lavage fluid (BALF). In addition, his sputum contained many hemosiderin-laden macrophages, indicative of pulmonary hemorrhage. His chest roentgenogram on admission showed diffuse ground grass appearance. High resolution computed tomography (HRCT) demonstrated diffuse high density areas throughout the lung fields and characteristic irregularity and enlargement of the peripheral pulmonary arteries. His general condition rapidly deteriorated, but dramatically improved with oral steroid administration, and his major symptoms disappeared within a few days. Examination of the biopsied lung tissue revealed unequivocal evidence of pulmonary angitis with marked eosinophilic infiltration and perivascular granulomas. Bone marrow biopsy showed hyperplasia of eosinophilic leukocytes in contrast to the low cellularity. Suppression of erythroid hemopoiesis was thought to be the primary cause for his rapidly progressive anemia. Serum anti-GBM antibody titer returned to within the normal range soon after the initiation of steroid therapy.
authors.affiliation: Department of Respiratory Disease, Takatsuki Red Cross Hospital, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Masuzaki
authors.forename: M
authors.initials: M
authors.lastname: Iwanishi
authors.forename: M
authors.initials: M
authors.lastname: Umemiya
authors.forename: K
authors.initials: K
authors.lastname: Misaki
authors.forename: S
authors.initials: S
authors.lastname: Sumitomo
authors.forename: N
authors.initials: N
authors.lastname: Fujimura
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Heki
authors.forename: M
authors.initials: M
authors.lastname: Kanaoka
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis*; D001323:Autoantibodies; D001853:Bone Marrow / Q000473:pathology; D015267:Churg-Strauss Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D000906:Antibodies; D001323:Autoantibodies; C051951:antiglomerular basement membrane antibody; D011239:Prednisolone