[Isolation of bone morphogenetic protein from human osteosarcoma tissue].
Isolated from an osteosarcoma specimen from a 15-year-old girl and assayed by implantation, partly purified lyophilized bone morphogenetic protein (BMP) induced heterotopic ossification in the mouse quadriceps. The apparent molecular weight was 18 kDa. Osteosarcoma-derived BMP induced the same process of bone development as human BMP from normal bone matrix.
Kübler
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Bone Research Laboratory, University of California at Los Angeles.
Urist
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D000293:Adolescent; D000818:Animals; D001681:Biological Assay; D019485:Bone Morphogenetic Proteins; D001859:Bone Neoplasms / Q000737:chemistry*; D005260:Female; D006133:Growth Substances / Q000302:isolation & purification; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry / Q000556:secondary*; D051379:Mice; D009363:Neoplasm Proteins / Q000302:isolation & purification*; D010012:Osteogenesis; D012516:Osteosarcoma / Q000737:chemistry*; D011506:Proteins / Q000302:isolation & purification*; D013977:Tibia
D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D009363:Neoplasm Proteins; D011506:Proteins
Die Isolation von Bone Morphogenetic Protein aus humanem Osteosarkomgewebe.