Serologic response to Pneumocystis carinii of Seoul National University Hospital patients.
A total of 2,580 sera of the patients who were consulted to the serology laboratory of the Seoul National University Hospital were collected in 1990. The sera were screened by micro-ELISA to detect IgG antibody reacting with Pneumocystis carinii antigen. The absorbances were 0.00 to 1.41 and mean 0.27 +/- 0.253. As the positive criterion was set absorbance 0.2 or more with 70% sensitivity, total positive rate was 44.4%. Mean absorbances and positive rates were higher in children than in adults; 0.40 and 62.9% in 0 year group, 0.50 and 81.2% in 1 year group, 0.41 and 66.0% in 2-3 year group, 0.33 and 61.4% in 4-5 year group, 0.25 and 42.3% in 6-10 year group respectively. In the age groups over 11 years, the absorbances were in range of 0.16 to 0.23 and the positive rates were 26.1% to 41.5%. The present level of absorbances and positive rates could be regarded similar with those in normal Korean population. The present findings suggest that most humans are exposed to Pneumocystis within 2 years after birth and meet much less new antigenic challenge after 11 years in Korea.
Hong
S T
ST
Department of Parasitology, Seoul National University College of Medicine, Korea.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000908:Antibodies, Fungal / Q000032:analysis*; D000946:Antigens, Fungal / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007223:Infant; D007723:Korea; D008297:Male; D008875:Middle Aged; D011010:Pneumocystis / Q000276:immunology*; D051381:Rats
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D007074:Immunoglobulin G