title: Effect of exogenous ascorbic acid on experimental hypertension and mineral balance in rats fed low- and high-fat diets.
abstract: The effects of exogenous ascorbic acid on the development of experimental hypertension and on calcium, sodium, and potassium metabolism have been studied. The investigation was carried out in 90 4-mo-old male Wistar rats fed high- and low-fat diets. Hypertension was induced by administering a 1.5% solution of NaCl orally. Some rats received 0.1% ascorbic acid in distilled water orally for the first 7 wk of the experiment, then 0.3% for the next 5 wk. The results showed that the amount of fat, NaCl, and ascorbate in the diet may play a role in the etiopathogenesis of hypertension. A high-fat high-NaCl diet increased blood pressure more than a low-fat high-NaCl diet. Additional intake of 0.3% ascorbate solution reduced experimentally induced hypertension by 4% with a low-fat diet and by 14% with a high-fat diet. Also, 0.3% ascorbate solution had a blood-pressure-lowering effect in rats fed a high-fat diet without NaCl. Supplementation with ascorbate diminished urine calcium output with a high-fat diet and increased the urine PGE2/PGF2 ratio with both low- and high-fat diets.
authors.affiliation: Department of Nutrition Physiology and Biochemistry, National Food and Nutrition Institute, Warsaw, Poland.
authors.forename: S
authors.initials: S
authors.lastname: Ziemlański
authors.forename: M
authors.initials: M
authors.lastname: Wartanowicz
authors.forename: K
authors.initials: K
authors.lastname: Potrzebnicka
authors.forename: A
authors.initials: A
authors.lastname: Burgos de Moor
authors.forename: K
authors.initials: K
authors.lastname: Iwanow
authors.forename: M
authors.initials: M
authors.lastname: Ignatowska-Switalska
authors.forename: K
authors.initials: K
authors.lastname: Zelakiewicz
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D002118:Calcium / Q000652:urine; D004041:Dietary Fats / Q000008:administration & dosage*; D015237:Dinoprost / Q000652:urine; D015232:Dinoprostone / Q000652:urine; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D004041:Dietary Fats; D012965:Sodium Chloride; D015237:Dinoprost; D015232:Dinoprostone; D001205:Ascorbic Acid; D002118:Calcium