Poly(ADP-ribose) polymerase: molecular biological aspects.
A number of roles have been ascribed to poly(ADP-ribose) polymerase* including involvement in DNA repair, cell proliferation, differentiation and transformation. Cloning of the gene has allowed the development of molecular biological approaches to elucidate the structure and the function(s) of this highly conserved enzyme. This article will review the recent results obtained in this field.
de Murcia
G
G
Institut de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Strasbourg, France.
Ménissier-de Murcia
J
J
Schreiber
V
V
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002467:Cell Nucleus / Q000378:metabolism; D002645:Chickens / Q000235:genetics / Q000378:metabolism; D016384:Consensus Sequence; D004247:DNA / Q000235:genetics / Q000378:metabolism; D005796:Genes; D006801:Humans; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D009243:NAD / Q000378:metabolism; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D016335:Zinc Fingers / Q000235:genetics
D009243:NAD; D011064:Poly Adenosine Diphosphate Ribose; D004247:DNA; D011065:Poly(ADP-ribose) Polymerases