title: [New inhibitors of aromatase: synthesis and biological activity of pyridyl-substituted phenanthrenone derivatives].
abstract: The phenanthrenone derivatives 3-6 were synthesized and tested for their aromatase and desmolase inhibitory potency. Compounds 5 and 6 show a stronger inhibition of aromatase than aminoglutethimide not exceeding, however, the activity of the parent compounds 1 and 2. Compounds 4 and 5 do not inhibit desmolase.
authors.affiliation: Fachrichtung Pharmazeutische Chemie, Universität des Saarlandes.
authors.forename: H
authors.initials: H
authors.lastname: Bayer
authors.forename: R W
authors.initials: RW
authors.lastname: Hartmann
mesh_terms: D047072:Aromatase Inhibitors; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000037:antagonists & inhibitors; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D047072:Aromatase Inhibitors; D010616:Phenanthrenes; D011725:Pyridines; D002786:Cholesterol Side-Chain Cleavage Enzyme
vernacular_title: Neue Hemmstoffe der Aromatase: Synthese und biologische Aktivität pyridyl-substituierter Phenanthrenonderivate.