[Use of hypertonic saline solutions in intensive care and emergency medicine--developments and perspectives].
The primary factor rendering patients at risk of developing multiple system organ failure after shock and trauma is the persistence of impaired microcirculation along with its sequelae for cellular and organ function. Bolus infusion (2-5 min) of 4 ml/kg hypertonic/hyperoncotic saline solution through a peripheral vein is a new concept for primary resuscitation from severe hypovolemia associated with trauma and hemorrhage and is termed "small-volume resuscitation". The experimental data obtained by various research groups have demonstrated the efficacy of 7.2%-7.5% saline solution in restoring central hemodynamics and organ blood flow. The simultaneous application of a hyperoncotic colloid (6%-10% dextran 60/70; 6%-10% hydroxyethylstarch 200,000) aims at prolonging the circulatory effect of saline. Of particular importance are the data obtained in experiments on traumatic-hemorrhagic hypovolemia in beagles, which proved that the infusion of 10% dextran 60 in 7.2% saline (hypertonic-hyperoncotic solution) restores nutritional blood flow within less than 5 min, thereby enhancing the circulatory effect of hypertonic saline alone. In the pre-clinical setting, small-volume resuscitation by means of hypertonic saline/dextran solution is aimed at the rapid normalization of the compromised microcirculation and, thus, at the prevention of late complications such as sepsis and multiple system organ failure. The novelty of hypertonic saline/dextran resuscitation lies in its operational mechanism at the microcirculatory level, which also renders this concept attractive for volume support in endotoxemia and septic shock.(ABSTRACT TRUNCATED AT 250 WORDS)
Kreimeier
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U
Institut für Chirurgische Forschung, Klinikum Grosshadern, Ludwig-Maximilians-Universität München.
Messmer
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K
D001810:Blood Volume / Q000187:drug effects / Q000502:physiology; D003422:Critical Care; D004630:Emergencies; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009102:Multiple Organ Failure / Q000503:physiopathology / Q000628:therapy*; D009104:Multiple Trauma / Q000503:physiopathology / Q000628:therapy*; D012151:Resuscitation / Q000379:methods; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*
D012462:Saline Solution, Hypertonic
Zum Einsatz hypertoner Kochsalzlösungen in der Intensiv- und Notfallmedizin--Entwicklungen und Perspektiven.