title: Sequence of swallow, a gene required for the localization of bicoid message in Drosophila eggs.
abstract: We report the sequence of the Drosophila maternal effect gene swallow, one of the genes whose product is required for the localization of bicoid message during Drosophila oogenesis. The inferred swallow protein contains a domain that is predicted to be an amphipathic alpha-helix similar to those implicated in protein:protein associations in other systems. Another part of the predicted protein appears to be a diverged RNA-binding motif. We discuss these structural features in light of the function of the swallow protein in the bicoid message localization process.
authors.affiliation: Department of Biology, University of Rochester, New York.
authors.forename: Y C
authors.initials: YC
authors.lastname: Chao
authors.forename: K M
authors.initials: KM
authors.lastname: Donahue
authors.forename: N J
authors.initials: NJ
authors.lastname: Pokrywka
authors.forename: E C
authors.initials: EC
authors.lastname: Stephenson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development; D029721:Drosophila Proteins; D005260:Female; D018398:Homeodomain Proteins; D007301:Insect Hormones / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D009866:Oogenesis / Q000235:genetics*; D011485:Protein Binding; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics*; D015183:Restriction Mapping; D016415:Sequence Alignment; D015534:Trans-Activators
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D007301:Insect Hormones; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D015534:Trans-Activators; C056478:bcd protein, Drosophila; C073970:swa protein, Drosophila; D004247:DNA