B cell commitment.
Multipotential stem cells have the capacity to differentiate into a variety of cell types including B lymphocytes. The development of B cells from multipotential progenitors has been the subject of numerous studies and many aspects of this transition are well characterized. However, the initial genetic events which commit a stem cell to follow the B lineage developmental pathway have not yet been discovered. In this review we examine diverse experiments which may lead to increased understanding of the important first steps in the commitment process.
Paige
C J
CJ
Division of Cell and Molecular Biology, Ontario Cancer Institute, Toronto, Canada.
Cumano
A
A
Wu
G E
GE
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation; D005803:Genes, Immunoglobulin; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008264:Macrophages / Q000166:cytology; D051379:Mice; D016184:Receptors, Colony-Stimulating Factor / Q000502:physiology
D016298:Hematopoietic Cell Growth Factors; D016184:Receptors, Colony-Stimulating Factor