Collaborative Transplant Study Kidney Exchange Trial for highly sensitized recipients.
1. A better than 70% 1-year graft success rate was obtained in highly sensitized recipients of first and second kidney transplants. Recipients of third or fourth transplants had a 25% lower success rate. 2. The results of this trial show a strong influence of HLA matching in highly sensitized recipients. HLA-DR mismatches appear to be most deleterious, followed by HLA-B mismatches. 3. Thirty transplants with 0 mismatches for HLA-B, -DR had an excellent 88% 1-year graft survival rate. 4. The strong effect of HLA matching mandates the national and international exchange of kidneys for highly sensitized recipients.
Opelz
G
G
Department of Transplantation Immunology, University of Heidelberg, Germany.
D005500:Follow-Up Studies; D006085:Graft Survival / Q000276:immunology; D015235:HLA-B Antigens / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D006650:Histocompatibility Testing / Q000706:statistics & numerical data*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology / Q000706:statistics & numerical data*; D008214:Lymphocytes / Q000276:immunology*; D011183:Postoperative Complications / Q000276:immunology / Q000401:mortality*; D012086:Reoperation; D015996:Survival Rate; D014019:Tissue Donors / Q000706:statistics & numerical data*
D015235:HLA-B Antigens; D006684:HLA-DR Antigens