title: Identification of a gene encoding an HPr-like protein in Aspergillus fumigatus.
abstract: The gene encoding a histidine-containing protein (HPr)-like protein was identified in a cDNA library of Aspergillus fumigatus. The predicted amino acid sequence of the fungal HPr showed greater homology with HPr from Gram-positive bacteria than from Gram-negative bacteria. Since other components of the phosphoenolpyruvate: carbohydrate phosphotransferase system have not been identified in eukaryotes, this raises the question of what regulatory function the HPr-like protein might have evolved in this fungus.
authors.affiliation: Department of Medical Microbiology, Manchester University, UK.
authors.forename: S
authors.initials: S
authors.lastname: Barker
authors.forename: R
authors.initials: R
authors.lastname: Matthews
authors.forename: W
authors.initials: W
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Bostock
authors.forename: J
authors.initials: J
authors.lastname: Burnie
mesh_terms: D000595:Amino Acid Sequence; D001232:Aspergillus fumigatus / Q000737:chemistry / Q000235:genetics*; D001426:Bacterial Proteins; D001483:Base Sequence; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics*; D005800:Genes, Fungal; D006090:Gram-Negative Bacteria / Q000235:genetics; D006094:Gram-Positive Bacteria / Q000235:genetics; D006639:Histidine / Q000032:analysis; D008969:Molecular Sequence Data; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000737:chemistry / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D001426:Bacterial Proteins; D005656:Fungal Proteins; C074716:Hpr-like protein, Aspergillus fumigatus; D006639:Histidine; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; C030182:phosphocarrier protein HPr