Possible importance for laminitis research of recent studies on substances influencing the differentiation of cultured keratinocytes.
After a survey of the state of laminitis research the authors conclude that none of the present concepts of the pathogenesis of laminitis unequivocally explains the basic clinical and morphological observations in this disease. There is therefore reason to consider the advances that have been made during the last decades in respect to the influence of various substances on the differentiation of cultured skin keratinocytes. The technique is available for studying hoof keratinocytes in a comparable way. Relevant literature on cultured skin keratinocytes is surveyed. Some of the results from experimental studies on skin keratinocytes have an obvious connection with observations in laminitis, a fact which has led the authors to hypothesize that laminitis may be a "multifactorial" disease and that it may be provoked by agents stimulating multiplication of hoof keratinocytes with consequent reduction of differentiation.
Ekfalck
A
A
Department of Clinical Chemistry, College of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
Jones
B
B
Obel
N
N
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D005534:Foot Diseases / Q000473:pathology / Q000662:veterinary; D006724:Hoof and Claw / Q000473:pathology*; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D015603:Keratinocytes / Q000187:drug effects*