Cytotoxic norditerpene lactones from Ileostylus micranthus.
Three new compounds 2-4 and two known compounds 1 and 5 have been isolated from the cytotoxic fraction of an extract from a New Zealand mistletoe, Ileostylus micranthus. Compounds 1-5 are shown to be norditerpene lactones and have strong cytotoxicity. The compounds are proposed to have been assimilated by the mistletoe from the host tree, Podocarpus totara.
Bloor
S J
SJ
DSIR Chemistry, Petone, New Zealand.
Molloy
B P
BP
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D007783:Lactones