title: Dextrorphan blocks long- but not short-term memory in a passive avoidance task in rats.
abstract: In the present study a mixed sigma and PCP (phencyclidine) site ligand, dextrorphan (22 mg/kg), blocked long- but not short-term memory in a passive avoidance task. This effect was not accompanied by any behavioral alterations that could interfere with passive avoidance performance. The action of dextrorphan was shared by a selective NMDA (N-methyl-D-aspartate) receptor antagonist, MK-801 (5-methyl-10,11-dihydro-5H-dibenzocyclohepten-5,10-imine maleate, 0.1 mg/kg). The results suggest that dextrorphan affects long-term memory, probably via blockade of NMDA receptors.
authors.affiliation: Nencki Institute of Experimental Biology, Warsaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Sierocinska
authors.forename: E
authors.initials: E
authors.lastname: Nikolaev
authors.forename: W
authors.initials: W
authors.lastname: Danysz
authors.forename: L
authors.initials: L
authors.lastname: Kaczmarek
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003917:Dextrorphan / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D008570:Memory, Short-Term / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003917:Dextrorphan