[Synthesis of partial structure of complex types of N-glycoproteins].
Comparable syntheses of beta-D-GlcpNAc-(1----2)-[beta-D-GlcpNAc-(1----6)]-alpha-D-Manp-(1- ---6)-beta-D-ManpO(CH2)8CO2Me and beta-D-GlcpNAc-(1----2)-alpha-D-Manp-(1----3)-beta-D-ManpO(C H2)8CO2Me with the glycosyl halide and imidate methods were investigated. 3,4,6-Tri-O-acetyl-2-deoxy-(2,2,2-trichloroethoxycarbonylamino)-al pha-D-glucopyranosyl bromide or trichloroacetimidate are suitable glycosyl donors for beta-D-glycoside coupling with secondary hydroxyl groups.
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Institut für Organische Chemie der Universität Hamburg, Bundesrepublik Deutschland.
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D002240:Carbohydrate Sequence; D006023:Glycoproteins / Q000138:chemical synthesis* / Q000737:chemistry; D008969:Molecular Sequence Data; D015394:Molecular Structure
D006023:Glycoproteins
Synthese von Teilstrukturen der N-Glycoproteine des komplexen Typs.