Regenerative ability of hepatocytes is inhibited in early stages of liver fibrosis.
Female Wistar rats were given three doses of carbon tetrachloride, 10.4 mmol/kg of body weight. The doses were administered within 16 days and another 16 days were allowed to pass before partial (37%) hepatectomy was done. The liver showed very mild fibrosis at that time. DNA synthesis (measured by 3H-thymidine incorporation) was decreased by 53% and mitotic activity of hepatocytes was decreased by 56% when compared to olive oil-pretreated partially hepatectomized controls. The results show that the mitotic potential of hepatocytes in early stages of liver fibrosis is impaired which may influence the course of the disease.
Kanta
J
J
Department of Physiology, Faculty of Medicine, Charles University, Hradec Králové.
Chlumská
A
A
D000818:Animals; D002251:Carbon Tetrachloride; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007700:Kinetics; D008106:Liver Cirrhosis, Experimental / Q000503:physiopathology*; D008115:Liver Regeneration; D008938:Mitosis; D051381:Rats; D011919:Rats, Inbred Strains
D004247:DNA; D002251:Carbon Tetrachloride