title: Statistical issues arising from mouse micronucleus assay experiments of Ashby and co-workers.
abstract: Data from a series of mouse micronucleus assays have been reanalysed to illustrate various statistical issues raised by Ashby and co-workers during the development of the assay. Most of the statistical points discussed in these earlier papers can be explained by the stochastic nature of the data. Reanalysis shows that the type of data collected in mammalian micronucleus assays is amenable to analysis by standard biometric methods. It is concluded that statistical analysis has an important role in the exploration and interpretation of data from the micronucleus assay.
authors.affiliation: British Industrial Biological Research Association, Carshalton, Surrey, UK.
authors.forename: D P
authors.initials: DP
authors.lastname: Lovell
authors.forename: I D
authors.initials: ID
authors.lastname: Mitchell
authors.forename: P
authors.initials: P
authors.lastname: Godbert
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D051379:Mice; D015162:Micronucleus Tests / Q000706:statistics & numerical data*
chemical_list: D008769:Methylnitronitrosoguanidine