title: Influence of adrenaline on blood perfusion and vascular conductance of the whole pancreas and the islets of Langerhans in the rat.
abstract: The blood perfusion and vascular conductance of the whole pancreas and of the islet organ were measured separately with the aid of a microsphere technique after intravenous infusion (0.1 ml/min) of adrenaline in different doses (1, 2 or 3 micrograms/kg body weight x min). Control animals were infused with saline alone and had a mean arterial blood pressure of approximately 100 mm Hg. Adrenaline increased the mean arterial blood pressure to 150, 175 and 200 mm Hg, respectively. A decrease of both whole pancreatic blood flow and islet blood flow could be seen after adrenaline administration, but no differences were observed between the two highest doses (greater than 2 micrograms/kg body weight x min of adrenaline). The fraction of blood diverted through the islets was approximately 10% of the whole pancreatic blood flow in all experimental groups. Also the vascular conductance decreased more than the blood perfusion values. It is concluded that adrenaline produces a decrease of blood flow to both the islets and the whole pancreas, which is similar in both the endocrine and exocrine tissue.
authors.affiliation: Department of Medical Cell Biology, Uppsala University, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Jansson
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000098:blood supply / Q000187:drug effects*; D008297:Male; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D004837:Epinephrine