title: Improvement in allograft survival of islets of Langerhans by pretreatment with deoxyguanosine.
abstract: In vitro pretreatment of isolated islets of Langerhans prior to transplantation with deoxyguanosine (dGuo) was found to be effective in improving the survival in fully allogeneic diabetic rats (Wistar----PVG). Post transplant immunosuppression was not used. Islets pretreated with various concentrations of dGuo, 1, 1.35, 1.5 and 2 microM dGuo per islet showed a graft survival of 9, 36, 9 and 14% respectively.
authors.affiliation: Department of Surgery, Hahnemann University, Philadelphia, Pennsylvania 19102.
authors.forename: I H
authors.initials: IH
authors.lastname: al-Abdullah
authors.forename: M S
authors.initials: MS
authors.lastname: Kumar
authors.forename: M S
authors.initials: MS
authors.lastname: al-Adnani
authors.forename: G M
authors.initials: GM
authors.lastname: Abouna
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003849:Deoxyguanosine / Q000494:pharmacology* / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000601:surgery*; D006085:Graft Survival / Q000187:drug effects; D016381:Islets of Langerhans Transplantation / Q000473:pathology / Q000502:physiology*; D008099:Liver / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous
chemical_list: D001786:Blood Glucose; D003849:Deoxyguanosine