[Antiulcer action and mechanism of trifluoperazine in rat stomach].
Trifluoperazine (TFP) 5, 10, 20 mg.kg-1 ig inhibited the formation of gastric ulcers induced by pyloric ligation, stress and indomethacin in rats and showed dose-effect dependence. TFP 10, 20 mg.kg-1 ig depressed the secretion of gastric juice, acid, and pepsin, but TFP 5, 10, 20 mg.kg-1 ig had no influence on the pepsin activity. TFP 20 mg.kg-1 ig inhibited the gastric H+, K(+)-ATPase activity of both stress and indomethacin ulcers in rats in vivo, and the gastric H+, K(+)-ATPase activity was also inhibited by TFP 50 mumol.L-1 in vitro. The results suggested that the inhibition of gastric H+, K(+)-ATPase activity and gastric secretion might be related to the antiulcer mechanism of TFP.
Li
Y
Y
Department of Pharmacology, Zhejiang Medical University, Hangzhou, China.
Yong
D G
DG
Geng
B Q
BQ
Gu
G G
GG
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000378:metabolism / Q000517:prevention & control*; D014268:Trifluoperazine / Q000494:pharmacology* / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D014268:Trifluoperazine