[The restriction of hemodynamic disorders in acute hypoxia and in situ reoxygenation by using the synthetic peptide bioregulator dalargin].
Development of posthypoxic and reoxygenation depression of cardiac activity following a time-portioned disconnection of the apparatus for artificial ventilation of the lungs in rats was restricted by a preventive intravenous infusion of a synthetic opioid peptide--dalargin. Resistance to a stressor effect of hypoxia (ischemia-reperfusion) which was assessed by the degree of restoration of the integral index of the blood circulation--cardiac output could be mediated by correction of Ca-homeostasis of cardiomyocytes by means of dalargin. Elimination of all side effects with a blocker of opioid receptors--naloxon points to a possibility of realization of a protective antihypoxic action.
Pashutin
S B
SB
D000208:Acute Disease; D000818:Animals; D001237:Asphyxia / Q000188:drug therapy / Q000503:physiopathology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012121:Respiration, Artificial; D013997:Time Factors
D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Ogranichenie gemodinamicheskikh narusheniĭ pri ostroĭ gipoksii i reoksigenatsii in situ s pomoshch'iu sinteticheskogo peptidnogo bioreguliatora dalargina.