[Nuclear triiodothyronine receptors in the testis of the growing rat are regulated by the thyroid status].
The effects of thyroid status on the binding capacity, association constant (Ka) and receptor occupancy during postnatal rat testis development were evaluated. Hypothyroidism (induced by oral administration of 0.05% methimazole from the day of birth) increased the total T3 binding capacity in the testis, retarding the normal developmental decrease in T3 receptor number (mean maximal binding capacities estimated by Scatchard analysis for 21-day-old eu- and hypothyroid rats were 117 and 173 fmol/mg DNA, respectively). The rat thyroid status also affected the percentage of T3 receptor occupancy but not the affinity of binding (as measured by Ka). The postnatal developmental changes in T3 binding capacity induced by hypothyroidism were completely reversed by T3 replacement. These results suggest that T3 nuclear receptors in the developing rat testis are modulated by thyroid hormones.
Palmero
S
S
Istituto di Fisiologia Generale, Sezione di Genova, Università di Genova.
De Marco
P
P
Trucchi
P
P
Prati
M
M
Fugassa
E
E
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002467:Cell Nucleus / Q000378:metabolism; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008713:Methimazole / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains / Q000254:growth & development / Q000502:physiology; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D012708:Sertoli Cells / Q000378:metabolism / Q000648:ultrastructure; D013737:Testis / Q000254:growth & development / Q000378:metabolism*; D013963:Thyroid Hormones / Q000097:blood / Q000502:physiology*; D014284:Triiodothyronine / Q000494:pharmacology; D015854:Up-Regulation
D011988:Receptors, Thyroid Hormone; D013963:Thyroid Hormones; D014284:Triiodothyronine; D008713:Methimazole
I recettori nucleari per la tri-iodotironina nel testicolo del ratto pubere sono regolati dallo stato tiroideo.