The effect of CV-3988 and CV-6209 on the acute gastric erosions of rats due to water-immersion and restraint stress.
CV-3988 and CV-6209 inhibited gastric erosions in rats due to water-immersion and restraint stress in a dose-dependent manner. The above inhibitory effects of CV-3988 were observed in the presence of indomethacin, which may indicate that the inhibition is not prostaglandin dependent. The studies indicate that platelet-activating factor may be involved in the formation of erosions in rats under water-immersion and restraint stress.
Nogami
M
M
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
Hoshihara
Y
Y
Tsubura
K
K
Yamamoto
T
T
Tabuchi
M
M
Miyamoto
T
T
Shiga
J
J
D000704:Analysis of Variance; D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D007101:Immersion; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010742:Phospholipid Ethers / Q000627:therapeutic use*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011726:Pyridinium Compounds / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013270:Stomach / Q000187:drug effects / Q000473:pathology*; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000503:physiopathology*
D010742:Phospholipid Ethers; D010972:Platelet Activating Factor; D011726:Pyridinium Compounds; C053321:CV 6209; C037913:CV 3988; D007213:Indomethacin