Synthesis and nonthrombogenicity of polyetherurethaneurea film grafted with poly(sodium vinyl sulfonate).
Synthesis of nonthrombogenic materials without using biologically active substances was explored. Poly(sodium vinyl sulfonate) is a water-soluble synthetic polymer and activates antithrombin III to exert nonthrombogenicity that was dependent on the molecular weight. Polyetherurethaneurea film was plasma-treated and graft-polymerized with sodium vinyl sulfonate. The graft film showed excellent in vitro and ex vivo nonthrombogenicity by suppressing interactions with plasma proteins and platelets as well as by inactivating blood-clotting factors.
Ito
Y
Y
Department of Polymer Chemistry, Kyoto University, Japan.
Iguchi
Y
Y
Kashiwagi
T
T
Imanishi
Y
Y
D000327:Adsorption; D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D001672:Biocompatible Materials; D001777:Blood Coagulation / Q000187:drug effects; D001798:Blood Proteins / Q000737:chemistry; D002478:Cells, Cultured; D004285:Dogs; D005347:Fibroblasts / Q000187:drug effects; D006493:Heparin; D051379:Mice; D010314:Partial Thromboplastin Time; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011140:Polyurethanes / Q000138:chemical synthesis / Q000494:pharmacology*; D011145:Polyvinyls / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D013451:Sulfonic Acids; D013499:Surface Properties; D013927:Thrombosis / Q000097:blood
D001672:Biocompatible Materials; D001798:Blood Proteins; D011140:Polyurethanes; D011145:Polyvinyls; D013451:Sulfonic Acids; C008959:lyapolate; D000990:Antithrombin III; D006493:Heparin; C044690:polyetherurethane urea