title: Eosinophilic leukemia: a myeloproliferative disorder distinct from the hypereosinophilic syndrome.
abstract: Evidence to support the existence of eosinophilic leukemia (EL) as an autonomous eosinophilic proliferation analogous to other myeloproliferative disorders has been somewhat confusing. Partially obscuring the existence of EL as a distinct entity is the proposal that EL merely represents a clinically aggressive form of hypereosinophilic syndrome. This report details the clinical and pathologic findings in a case of EL. The presence of trisomy 8 and trisomy 21; morphologic, cytochemical, and ultrastructural findings of granular abnormalities and nuclear/cytoplasmic dysynchrony; and a clinical course similar to that of other myeloproliferative disorders support the existence of EL as a rare but distinct entity within the spectrum of myeloproliferative diseases.
authors.affiliation: Department of Pathology, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: B D
authors.initials: BD
authors.lastname: Kueck
authors.forename: R E
authors.initials: RE
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Parkin
authors.forename: L C
authors.initials: LC
authors.lastname: Peterson
authors.forename: C A
authors.initials: CA
authors.lastname: Hanson
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods; D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure; D004802:Eosinophilia / Q000473:pathology*; D016313:Genes, abl / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D015472:Leukemia, Eosinophilic, Acute / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D009196:Myeloproliferative Disorders / Q000473:pathology*; D013577:Syndrome