Synthesis of (+/-)-N-2-methylpropyl-N-1'-methylacetonyl-nitrosamine.
N-2-methylpropyl-N-1-methylacetonyl-nitrosamine (NMAMPA), first isolated from moldy and normal foods, was synthesized by chemical means. The structure and molecular weight of the synthetic NMAMPA were elucidated by spectrometry. A combination of spectral and chromatographic data indicated that the synthetic NMAMPA is identical to that obtained naturally. Synthetic NMAMPA is a racemic modification, and a carcinogen which can induce esophageal and forestomach cancer in rats.
Li
G
G
Institute of Oncology, CAMS, Beijing.
Li
M
M
Ma
J
J
Zhao
S
S
D002273:Carcinogens / Q000138:chemical synthesis* / Q000737:chemistry; D009602:Nitrosamines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D002273:Carcinogens; D009602:Nitrosamines; C042824:N-2-methylpropyl-N-1-methylacetonylnitrosamine