title: [The differential diagnosis and principles of the prevention of thromboembolic complications in pregnant women with artificial heart valves].
abstract: Clinical and hemostasiologic examinations of 28 pregnant women with artificial heart valves helped detect various mechanisms of thrombophilia development. Marked platelet hyperactivity was detected in all the examinees, regarded as the principal pathogenetic risk factor of arterial thromboembolism. A wave-like course of the DIC syndrome with hypercoagulation replaced by hypocoagulation was recorded in 79.6% of pregnant women with artificial heart valves. Differentiated controlled antithrombotic therapy, administered with due consideration for the cause of thrombophilia, helped prevent thromboembolic complications.
authors.forename: A D
authors.initials: AD
authors.lastname: Makatsariia
authors.forename: I O
authors.initials: IO
authors.lastname: Sultanova
authors.forename: L M
authors.initials: LM
authors.lastname: Smirnova
mesh_terms: D000328:Adult; D001021:Aortic Valve; D001705:Bioprosthesis; D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000175:diagnosis / Q000517:prevention & control; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control; D013923:Thromboembolism / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control; D014261:Tricuspid Valve
vernacular_title: Differentsial'naia diagnostika i printsipy profilaktiki tromboémbolicheskikh oslozhneniĭ u beremennykh s iskusstvennymi klapanami serdtsa.