title: Serial measurement of serum fructosamine and glycosylated haemoglobin as indices of glycaemic control in diabetic pregnancy.
abstract: Management of diabetic pregnancy requires objective information regarding blood glucose levels with the aim of achieving strict euglycaemia. Self-blood glucose monitoring and measurement of glycosylated haemoglobin (HbA1) are two methods widely adopted in clinical practice. Serum fructosamine assay was recently introduced as a parameter for assessing short-term glycaemic control. Our study compared serial measurement of serum fructosamine with HbA1 as indices of short-term glycaemic control in a group of diabetic pregnant women prospectively from early/mid-trimester till delivery. Patients performed self-blood glucose glucose concentration of the preceding two weeks were assessed. Our results showed that both serum fructosamine and HbA1 gave comparable information regarding short-term glycaemic control. Serum fructosamine estimation did not offer any distinct additional advantage as a retrospective index of diabetic control in the management of diabetic pregnancy.
authors.affiliation: Department of Medicine, National University Hospital, Singapore.
authors.forename: A C
authors.initials: AC
authors.lastname: Thai
authors.forename: K F
authors.initials: KF
authors.lastname: Lui
authors.forename: E G
authors.initials: EG
authors.lastname: Low
authors.forename: W Y
authors.initials: WY
authors.lastname: Ng
authors.forename: L P
authors.initials: LP
authors.lastname: Kek
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring; D003920:Diabetes Mellitus / Q000097:blood* / Q000628:therapy; D005260:Female; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000032:analysis*; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D006595:Hexosamines