Impairment of neutrophil functions in a dog with an eosinophilic dermatosis.
An eosinophilic dermatosis was diagnosed in a dog with a multifocal distribution of pruritic, pustular and erosive lesions on the trunk. Ectoparasites, fungi and bacteria were not detected in the skin of the dog. At a subsequent admission to the university clinic, bacterial conjunctivitis and superficial pyoderma had developed. At a time when the dog received no medical therapy, evaluation of phagocytosis and chemotactic migration towards a variety of chemotactic factors revealed a general suppression of patient neutrophil responsiveness, as compared to a control dog. Viability of the patient's neutrophils was normal. It was proposed that deactivation of neutrophil functions occurred following exposure to suppressive factors from mast cells, or as a consequence of surface receptor down-regulation due to prolonged cell activation by as yet unknown stimulants. The observed susceptibility to infections in the dog suffering from a primary, sterile eosinophilic dermatosis may be related to impaired host defence against opportunistic microorganisms.
Thomsen
M K
MK
Department of Pharmacology, Leo Pharmaceutical Products, Ballerup, Denmark.
Jensen
A L
AL
Bindseil
E
E
Kristensen
F
F
D000818:Animals; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D004802:Eosinophilia / Q000276:immunology / Q000662:veterinary*; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology / Q000662:veterinary*