Screening for reproductive toxicity in rats for a decoction of Himathanthus sucuuba stem bark.
In order to evaluate the toxic potential of a Himathanthus sucuuba stem bark decoction, pregnant rats were treated from day 6 to day 15 of pregnancy with the decoction (40 mg per rat, twice a day) or distilled water (1.0 ml, twice a day) by gastric intubation. Half of the animals were killed on day 20 of pregnancy with the other half allowed to deliver. Maternal and fetal data suggest low reproductive toxicity and teratogenic potentiality and suggest that the beverage may be safe for human use in the treatment of gastritis and haemorrhoids.
Guerra
M O
MO
Department of Bioscience, Federal University of Juiz de Fora, Minas Gerais, Brazil.
Peters
V M
VM
D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000009:adverse effects*; D010946:Plants, Medicinal; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*; D013723:Teratogens / Q000633:toxicity
D010936:Plant Extracts; D013723:Teratogens