[The antiarrhythmic action of the synthetic acetylcholine analog EDIHYP in calcium chloride- and strophanthin-induced heart rhythm disorders].
The experiments on Wistar rats and chinchilla rabbits showed that EDIHYP (5 mg/kg intravenously) completely prevented cardiac fibrillation and mortality in rats with calcium-chloride-induced arrhythmias, (CaCl2-200 mg/kg intravenously). Administration of atropine (0.1 mg/kg, if administered subcutaneously, 30 minutes before the acute experiment) exerts no influence on the drug's antiarrhythmic activity but eliminates its cholinergic component--salivation and lacrimation. When administered in the same dose EDIHYP to a great extent prevents oubaine (strophanthin)-induced arrhythmias in rabbits but fails to influence aconitine-induced arrhythmias. This suggests that EDIHYP's ability of direct or indirect blockade of slow Ca-channels underlies the mechanism of its antiarrhythmic action.
Abdikaliev
N A
NA
Kalvin'sh
I Ia
IIa
Meerson
F Z
FZ
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D002122:Calcium Chloride; D004127:Dimethylhydrazines / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011422:Propionates / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013328:Strophanthins
D000889:Anti-Arrhythmia Agents; D004127:Dimethylhydrazines; D011422:Propionates; D013328:Strophanthins; C069515:ethyl 3-(2-ethyl-2,2-dimethylhydrazine)propionate; D002122:Calcium Chloride
Antiaritmicheskoe deĭstvie sinteticheskogo analoga atsetilkholina EDIGIP pri khloridkal'tsievykh i strofantinovykh narusheniiakh serdechnogo ritma.