Interferon gamma fails to activate human monocyte-derived macrophages to kill or inhibit the replication of a non-pathogenic mycobacterial species.
The ability of interferon gamma (gamma) to activate human macrophages to kill mycobacteria was investigated using a mycobacterial species that does not cause disease in man. Although interferon activated human macrophage activity against other intracellular parasites, Toxoplasma gondii and Listeria monocytogenes, it failed to activate human monocyte-derived macrophages to kill not only Mycobacterium tuberculosis but also the non-pathogenic species, Mycobacterium phlei.
Robertson
A K
AK
University of Leicester, Department of Microbiology, U.K.
Andrew
P W
PW
D000704:Analysis of Variance; D000818:Animals; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008089:Listeria monocytogenes / Q000276:immunology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology; D009161:Mycobacterium / Q000254:growth & development / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000276:immunology; D010587:Phagocytosis; D014122:Toxoplasma / Q000276:immunology
D007371:Interferon-gamma