Chromate nephrotoxicity in developing rats. Significance of Cr(VI) reduction in rat kidney tissue.
Chromate reduction was studied in 9000 x g supernatant of renal tissue. It was shown that GSH plays an important role. Additionally, heat-sensitive factor(s) seem to be involved. Age differences in chromate nephrotoxicity parallel differences in chromate reduction in vitro. The lower reductive activity of young rats can be raised to adult values by GSH-addition. Fasting reduces GSH concentration, as well as chromate nephrotoxicity, in vivo.
Appenroth
D
D
Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Fed. Rep. of Germany.
Friedrich
M
M
Friese
K H
KH
Bräunlich
H
H
D000375:Aging; D000818:Animals; D002840:Chromates / Q000633:toxicity*; D002857:Chromium / Q000378:metabolism*; D005215:Fasting; D005260:Female; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced*; D007700:Kinetics; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats
D002840:Chromates; D002857:Chromium; D005978:Glutathione; C034944:chromic acid