title: A new lipophilic gadolinium chelate as a tissue-specific contrast medium for MRI.
abstract: Gd-Ethoxybenzyl-DTPA (Gd-EOB-DTPA) is a highly water-soluble paramagnetic contrast agent. Due to its protein binding of about 10% and its lipophilic residue, Gd-EOB-DTPA exhibits both renal (30% of the dose) and hepatobiliary (70%) excretion in rats. Despite its lipophilic character, the compound displays a low toxicity (LD50 = 7.5 mmol/kg). T1-relaxivity of 5.3 liters mmol-1 s-1 in water, 8.7 liters mmol-1 s-1 in plasma, and 16.9 liters mmol-1 s-1 in rat liver together with the hepatocellular uptake explain the liver-specific contrast enhancement of Gd-EOB-DTPA. The diagnostic dose is considerably lower than the amount of Magnevist used in abdominal imaging. The preclinical studies suggest its clinical role as being a hepatobiliary contrast agent for MRI.
authors.affiliation: Institute of Contrast Media Research, Schering AG, Berlin, Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Weinmann
authors.forename: G
authors.initials: G
authors.lastname: Schuhmann-Giampieri
authors.forename: H
authors.initials: H
authors.lastname: Schmitt-Willich
authors.forename: H
authors.initials: H
authors.lastname: Vogler
authors.forename: T
authors.initials: T
authors.lastname: Frenzel
authors.forename: H
authors.initials: H
authors.lastname: Gries
mesh_terms: D000818:Animals; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D009942:Organometallic Compounds; D004369:Pentetic Acid; D051381:Rats; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C073590:gadolinium ethoxybenzyl DTPA; D004369:Pentetic Acid; D019786:Gadolinium DTPA