Effects of cepharanthin on neutrophil chemotaxis, phagocytosis, and reactive oxygen species generation.
The effects of cepharanthin on inflammatory parameters such as neutrophil chemotaxis, phagocytosis and reactive oxygen species (ROS) generation, were examined. Cepharanthin significantly decreased the levels of O2-, H2O2, and OH. generated by neutrophils. H2O2 and OH. generated in a cell-free, xanthine-xanthine oxidase system were also reduced in the presence of cepharanthin. However, the drug did not affect neutrophil chemotaxis or phagocytosis. The present study indicates that cepharanthin is an effective ROS scavenger, exerting its anti-inflammatory action by reducing the potent ROS species excessively generated in tissues and organs, especially at the sites of inflammation.
Akamatsu
H
H
Department of Dermatology, Kansai Medical University, Osaka, Japan.
Komura
J
J
Asada
Y
Y
Niwa
Y
Y
D000470:Alkaloids / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D044182:Benzylisoquinolines; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism*; D010587:Phagocytosis / Q000187:drug effects*; D052117:Benzodioxoles
D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D044182:Benzylisoquinolines; D010100:Oxygen; C006947:cepharanthine; D052117:Benzodioxoles