[Bronchoalveolar lavage in systemic scleroderma and systemic lupus erythematosus--differential cell values and enzyme cytochemistry].
The aim of the study was to determine the bronchoalveolar lavage (BAL) cell differentiation and the activity of beta-glucuronidase and N-acetyl-beta-D-glucosaminidase in alveolar macrophages. In 12 patients with systemic sclerosis (SS), 4 with systemic lupus erythematosus and 4 healthy controls BAL was performed. The activity of beta-glucuronidase and N-acetyl-beta-D-glucosaminidase was measured semiquantitative by means of cytochemical methods. Lymphocytes and neutrophils in BAL cell differentiation are increased, also the activity of beta-glucuronidase. The activity of N-acetyl-beta-D-glucosaminidase is decreased in SS and SLE in comparison with controls. The activity of beta-glucuronidase seems to be a marker of activity of alveolar macrophages in SS and SLE.
Witt
C
C
Klinik für Innere Medizin, Theodor Brugsch, Bereiches Medizin, Charité Humboldt-Universität zu Berlin.
Eckert
H
H
Brenke
A
A
Renner
H
H
Hiepe
F
F
D000118:Acetylglucosaminidase / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D005260:Female; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000473:pathology*; D012595:Scleroderma, Systemic / Q000473:pathology*
D005966:Glucuronidase; D000118:Acetylglucosaminidase
Bronchoalveoläre Lavage bei systemischer Sklerodermie und systemichem Lupus erythematodes--Differentialzellbild und Enzym-Zytochemie.