[Characteristics of adaptation to chemical damage studies on the example of phagocytic reactions of neutrophils].
The author believes that every cell is characterized by the inherent properties of the organism's reactivity as a whole. Therefore, studies of the adaptational reactions of the blood neutrophils exposed to metals chlorides can contribute to our knowledge of the body reactions to these substances. This research was based on a working hypothesis that the generally accepted universal applicability of the non-overlapping nucleotide triplet reaction with a high-reactivity form of a tropistic amino acid (e.i. in reactions with the participating units' ratio 3:1),- presents a universal characteristic of the biologic mechanism underlying reactivity. The adaptational mechanisms' activation, induced by 3 metal chlorides, rather than 1 or 2, proved to be more effective.
Tychinin
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VA
D000222:Adaptation, Physiological; D000818:Animals; D003300:Copper / Q000008:administration & dosage / Q000633:toxicity*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008627:Mercuric Chloride / Q000008:administration & dosage / Q000633:toxicity*; D008954:Models, Biological; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D009532:Nickel / Q000008:administration & dosage / Q000633:toxicity*; D010587:Phagocytosis / Q000187:drug effects* / Q000276:immunology; D051381:Rats
D008627:Mercuric Chloride; C022838:nickel chloride; D003300:Copper; D009532:Nickel; C029892:cupric chloride
Ob odnoĭ osobennosti adaptatsii k khimicheskomu povrezhdeniiu na primere fagotsitarnykh reaktsiĭ neĭtrofilov krovi.