title: The effect of food or milk on the absorption kinetics of ofloxacin.
abstract: We have studied the effects of food or milk on the absorption of ofloxacin in 21 healthy male volunteers in a three-way crossover design. Milk did not alter the rate or extent of absorption of ofloxacin or its elimination. Food altered the onset and/or rate of absorption, but not the extent of absorption or the elimination rate. Thus, food reduced peak ofloxacin concentrations (Cmax) by 20% compared with fasting conditions and the time to reach maximum concentration (tmax) was prolonged on average by 1 h. However, the extent of absorption and the half-life (t 1/2) of ofloxacin were the same after each treatment. These data indicate that food and milk have a clinically insignificant effect on ofloxacin absorption.
authors.affiliation: Antiinfective Pharmacology Research Unit, University of Rhode Island College of Pharmacy, Providence 02908.
authors.forename: M N
authors.initials: MN
authors.lastname: Dudley
authors.forename: C R
authors.initials: CR
authors.lastname: Marchbanks
authors.forename: S C
authors.initials: SC
authors.lastname: Flor
authors.forename: B
authors.initials: B
authors.lastname: Beals
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000818:Animals; D002214:Capsules; D005502:Food; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D008892:Milk / Q000378:metabolism*; D015242:Ofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D002214:Capsules; D015242:Ofloxacin