title: (-)-Grandisin form Cryptocarya crassinervia.
abstract: The known lignan (-)-grandisin [1] has been isolated from Cryptocarya crassinervia by using the brine shrimp lethality test to direct the isolation; its structure and relative stereochemistry have been determined by ir, 1H nmr, ms, and X-ray crystallography as an all-trans alpha, alpha'-diaryl-beta, beta'-dimethyltetrahydrofuran. Compound 1 is not significantly cytotoxic in our panel of human tumor cells.
authors.affiliation: Department of Biochemistry, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: J M
authors.initials: JM
authors.lastname: Saad
authors.forename: E
authors.initials: E
authors.lastname: Soepadamo
authors.forename: X P
authors.initials: XP
authors.lastname: Fang
authors.forename: J L
authors.initials: JL
authors.lastname: McLaughlin
authors.forename: P E
authors.initials: PE
authors.lastname: Fanwick
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D017705:Lignans; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction
chemical_list: D005663:Furans; D017705:Lignans; C074346:grandisin