X-ray analysis of a difluorostatone renin inhibitor bound as the tetrahedral hydrate to the aspartic protease endothiapepsin.
Hoover
D J
DJ
Department of Medicinal Chemistry, Central Research Division, Pfizer, Inc., Groton, CT 06340.
Veerapandian
B
B
Cooper
J B
JB
Damon
D B
DB
Dominy
B W
BW
Rosati
R L
RL
Blundell
T L
TL
D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors / Q000737:chemistry*; D001665:Binding Sites; D006801:Humans; D066298:In Vitro Techniques; D008958:Models, Molecular; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry; D011487:Protein Conformation; D014961:X-Ray Diffraction; D000092502:Renin Inhibitors
D016282:Aspartic Acid Endopeptidases; D009842:Oligopeptides; D000092502:Renin Inhibitors; C074407:CP 81282; C042466:Endothia aspartic proteinase