[Synthesis of lipoxygenase metabolites of arachidonic acid and their role in the pathogenesis of inflammation of gastric mucosa].
Concentrations of 5-, 12-, 15-HETE versus myeloperoxidase activity in the periulcerous area were investigated in 40 peptic ulcer patients. A control group consisted of 20 healthy subjects. In ulcer patients the activity of lipoxygenase pathway of metabolism of arachidonic acid and myeloperoxidase was enhanced. This is likely to promote chronic inflammation of the mucosa in the periulcerous area, this inflammation being an important prognostic factor for ulcerogenesis.
Pasechnikov
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VD
D001092:Arachidonate 12-Lipoxygenase / Q000096:biosynthesis; D001093:Arachidonate 15-Lipoxygenase / Q000096:biosynthesis; D001094:Arachidonate 5-Lipoxygenase / Q000096:biosynthesis; D001091:Arachidonate Lipoxygenases / Q000096:biosynthesis*; D002908:Chronic Disease; D004789:Enzyme Activation / Q000502:physiology; D005753:Gastric Mucosa / Q000201:enzymology*; D005756:Gastritis / Q000201:enzymology* / Q000209:etiology; D006801:Humans; D013276:Stomach Ulcer / Q000201:enzymology* / Q000209:etiology
D001091:Arachidonate Lipoxygenases; D001092:Arachidonate 12-Lipoxygenase; D001093:Arachidonate 15-Lipoxygenase; D001094:Arachidonate 5-Lipoxygenase
Sintez lipoksigenaznykh metabolitov arakhidonovoĭ kisloty i ikh rol' v patogeneze vospaleniia slizistoĭ obolochki zheludka.