[Psoralen sensitized thermoactivated photodamage to leukocyte membranes].
Psoralen sensitized photodamage of rat peritoneal exudate cells was investigated. Irradiation of cells induced latent lesions in membranes which during thermal activation at the post-irradiation stage were transformed into permeability channels for trypan blue. The effect linearly increased with fluence of irradiation which indicates one hit production of thermolabile psoralen photoproducts in the membranes.
Kiagova
A A
AA
Ismailova
M I
MI
Potapenko
A Ia
AIa
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000528:radiation effects; D011564:Furocoumarins / Q000494:pharmacology*; D006358:Hot Temperature; D007962:Leukocytes / Q000187:drug effects* / Q000528:radiation effects; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D014466:Ultraviolet Rays
D011564:Furocoumarins
Sensibilizirovannye psoralenom termoaktiviruemye fotopovrezhdeniia membran leĭkotsitov.