title: Hypothalamic monoamines and neuropeptides in dementia.
abstract: The concentrations of monoamines and various neuropeptides were determined in the hypothalamus of brains from patients with Alzheimer's disease and vascular dementia (n = 26) and compared with control values (n = 21). Decreased concentrations of 5-hydroxyindoleacetic acid (P less than 0.05) and homovanillic acid (P less than 0.01) were found, and increased arginine vasopressin- (P less than 0.01), galanin- (P less than 0.05) and somatostatin- (P less than 0.01) like immunoreactivity. It is proposed that this disequilibrium may be important for certain circadian symptoms, e.g. the changes in sleep/wake rhythms that are rather often observed in dementia.
authors.affiliation: Department of Psychiatry and Neurochemistry, Gothenburg University, St. Jörgen's Hospital, Hisings Backa, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Wallin
authors.forename: A
authors.initials: A
authors.lastname: Carlsson
authors.forename: R
authors.initials: R
authors.lastname: Ekman
authors.forename: C G
authors.initials: CG
authors.lastname: Gottfries
authors.forename: I
authors.initials: I
authors.lastname: Karlsson
authors.forename: L
authors.initials: L
authors.lastname: Svennerholm
authors.forename: E
authors.initials: E
authors.lastname: Widerlöv
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism; D015306:Biogenic Monoamines / Q000378:metabolism*; D003704:Dementia / Q000378:metabolism*; D015140:Dementia, Vascular / Q000378:metabolism; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009479:Neuropeptides / Q000378:metabolism*
chemical_list: D015306:Biogenic Monoamines; D009479:Neuropeptides