Hyperandrogenism: new insights into diagnosis and therapy.
Many different disease processes can result in a phenotype of hirsutism, anovulation, and oligomenorrhea or amenorrhea. An important goal of reproductive endocrinologists is to identify specific genetic diseases that can produce the hyperandrogenic phenotype. Two genetic disorders that can result in the hyperandrogenic phenotype are 1) mutations in the 21-hydroxylase gene (adrenal hyperplasia), and 2) mutations in the insulin receptor gene (the syndrome of hyperandrogenism-insulin resistance and acanthosis nigricans). The identification of these two genetic causes of hyperandrogenism provides the opportunity to investigate new approaches to prenatal diagnosis and therapy, genetic analysis of pedigrees, and innovative forms of therapy.
Barbieri
R L
RL
Department of Obstetrics and Gynecology, State University of New York, Stony Brook 11794-8091.
D000052:Acanthosis Nigricans / Q000209:etiology; D000311:Adrenal Glands / Q000473:pathology; D000728:Androgens / Q000096:biosynthesis*; D000858:Anovulation / Q000209:etiology; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D006965:Hyperplasia; D007333:Insulin Resistance; D008599:Menstruation Disturbances / Q000209:etiology
D000728:Androgens