Immunogenicity of a polypeptide fragment of the streptococcal group A M protein conjugated with an acrylic acid N-vinylpyrrolidone copolymer.
Immunization of animals with a polypeptide fragment of the streptococcal group A M protein (pep M) conjugated with a synthetic copolymer caused a significant increase in the titres of bactericidal type-specific antibodies. In some cases bactericidal antibodies to streptococci of other types were also induced.
Lyampert
I M
IM
Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow.
Semenova
E N
EN
Sanina VYu
Puchkova
N G
NG
Nekrasov
A V
AV
D000180:Acrylic Resins / Q000737:chemistry*; D000276:Adjuvants, Immunologic / Q000737:chemistry; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000276:immunology*; D002352:Carrier Proteins; D007106:Immune Sera / Q000032:analysis / Q000096:biosynthesis; D000922:Immunotoxins / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology*; D011205:Povidone / Q000031:analogs & derivatives* / Q000737:chemistry; D011817:Rabbits; D013297:Streptococcus pyogenes / Q000276:immunology*
D000180:Acrylic Resins; D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D007106:Immune Sera; D000922:Immunotoxins; D010446:Peptide Fragments; C014689:streptococcal M protein; C043348:acrylic acid-N-vinylpyrrolidone copolymer; D011205:Povidone