Research for new antichagasic drugs.
A series of ten 1-[(5-nitrothenylidene)amino]azoles has been synthesized by the reaction of 5-nitrothiophene-2-carbaldehyde with 1-aminopyrazole, 1-aminoimidazole, 1- and 4- amino-1,2,4-triazoles, 1-aminoindole, 1- and 2-aminoindazoles, 1-aminobenzimidazole and 1- and 2-aminobenzotriazoles. Physical data, spectroscopic characteristics and biological properties of all the derivatives have been examined. The antiprotozoal activity has been tested against Trypanosoma cruzi, comparative to Nifurtimox (Lampit).
Mester
B
B
Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Claramunt
R M
RM
Elguero
J
J
Atienza
J
J
Gómez Barrio
A
A
Escario
J A
JA
D000818:Animals; D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D014355:Chagas Disease / Q000188:drug therapy* / Q000523:psychology; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D007191:Indazoles / Q000138:chemical synthesis / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D009547:Nifurtimox / Q000494:pharmacology; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D013876:Thiophenes / Q000138:chemical synthesis / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
D001393:Azoles; D001562:Benzimidazoles; D007093:Imidazoles; D007191:Indazoles; D007211:Indoles; D009574:Nitro Compounds; D013876:Thiophenes; D014230:Triazoles; D014344:Trypanocidal Agents; D009547:Nifurtimox