title: Differences of contact photosensitivity responses to tetrachlorosalicylanilide among BALB/c, mast cell-deficient W/Wv and their normal littermate +/+ mice.
abstract: Time course of ear swellings induced in BALB/c mice with contact photosensitivity (CPS) of tetrachlorosalicylanilide (TCSA) exhibited a typical delayed-type hypersensitivity response. Repeated challenges by the painting of TCSA and UVA irradiation on ears once a week brought about the enhancement of the early CPS response immediately after elicitation. CPS response was not induced in the mast cell-deficient mouse (W/Wv) by the standard protocol and painting in its normal littermates (+/+). However, the second challenge performed 1 week after the first challenge brought about the delayed type-like CPS response of ear swelling in both mouse strains. The early responses were enhanced stepwise by the third and fourth challenge in the normal +/+ mouse but not in the mast cell-deficient W/Wv mouse. Histological examination revealed that mast cells were not found in the any sections of ears of W/Wv mouse, whereas many mast cells were found at early stage after elicitation in the BALB/c and +/+ mice challenged 4 times. These results suggest that early responses induced by the repeated challenge in BALB/c and +/+ but not in W/Wv mice may be an immediate-type hypersensitivity.
authors.affiliation: Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Masuzawa
authors.forename: T
authors.initials: T
authors.lastname: Oku
authors.forename: Y
authors.initials: Y
authors.lastname: Yanagihara
mesh_terms: D000485:Allergens; D000818:Animals; D004431:Ear, External / Q000473:pathology; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000473:pathology; D012458:Salicylanilides / Q000633:toxicity*; D014466:Ultraviolet Rays
chemical_list: D000485:Allergens; D012458:Salicylanilides; C003390:3,3',4',5-tetrachlorosalicylanilide