title: Effect of chlorpromazine hydrochloride on the formation of micronuclei in the bone marrow of mice exposed to gamma radiation.
abstract: The frequency of micronuclei was determined in the bone marrow of female BALB/c mice treated with various doses of chlorpromazine hydrochloride (CPZ) before exposure to 4.0 Gy of gamma radiation at 24 h post-exposure. In animals treated with CPZ alone, the frequency of micronuclei increased with the increase in drug dose. A similar pattern was observed when the mice were exposed to 4.0 Gy radiation after CPZ treatment. The dose response curves thus obtained for the CPZ treated and CPZ + irradiated groups were linear quadratic.
authors.affiliation: Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: G C
authors.initials: GC
authors.lastname: Jagetia
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005720:Gamma Rays; D051379:Mice; D008807:Mice, Inbred BALB C; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects / Q000528:radiation effects* / Q000648:ultrastructure
chemical_list: D002746:Chlorpromazine