title: Toxicity and mutagenicity of the molluscicidal plant Ambrosia maritima L.
abstract: The acute and subchronic toxicity of the molluscicidal plant, Ambrosia maritima L., has been tested on rats. No toxic signs could be detected neither after oral administration of 5 g/kg of dried leaves of the plant as a powder or as a methanolic extract, nor after the incorporation of 50,000 ppm powdered leaves in the feed during 4 weeks. Using an aqueous extract of the plant material of A. maritima or using ambrosin, one of the active molluscicidal components of the plant, no mutagenic activity could be detected in the S. typhimurium strains TA97, TA 98, TA1538, TA100 and TA1535.
authors.affiliation: Institute of Tropical Medicine, Veterinary Departement, Antwerp, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Alard
authors.forename: C
authors.initials: C
authors.lastname: Stievenart
authors.forename: P
authors.initials: P
authors.lastname: Vanparys
authors.forename: L
authors.initials: L
authors.lastname: Thilemans
authors.forename: S
authors.initials: S
authors.lastname: Geerts
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005260:Female; D008297:Male; D008975:Molluscacides / Q000008:administration & dosage / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000633:toxicity*; D010947:Plants, Toxic; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000032:analysis / Q000633:toxicity*; D045789:Sesquiterpenes, Guaiane
chemical_list: D008975:Molluscacides; D009153:Mutagens; D010936:Plant Extracts; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C010675:ambrosin