title: Potentiation of acetaldehyde-induced vasoconstrictions by cocaine in isolated and perfused arteries.
abstract: Vasoconstrictor responses to acetaldehyde (AA), norepinephrine (NE) and tyramine were investigated in isolated, perfused canine intermediate auricular (ear) arteries. Single injections of small doses of AA (1-3 mumol) induced a vasoconstriction in a dose-related manner and showed no tachyphylaxis. Cocaine significantly inhibited tyramine-induced vasoconstrictions, but NE- and AA-induced vasoconstrictions were rather significantly enhanced.
authors.affiliation: Department of Pharmacology, Shinshu University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Chiba
authors.forename: M
authors.initials: M
authors.lastname: Tsukada
mesh_terms: D000079:Acetaldehyde / Q000008:administration & dosage*; D000818:Animals; D003042:Cocaine / Q000008:administration & dosage*; D004285:Dogs; D004357:Drug Synergism; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000008:administration & dosage; D010477:Perfusion; D014439:Tyramine / Q000008:administration & dosage; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D000079:Acetaldehyde; D003042:Cocaine; D009638:Norepinephrine; D014439:Tyramine