Genetic polymorphism of the C4 component of human complement in the Slovak population.
The distribution of C4 phenotypes and gene frequencies were studied in 104 genetically unrelated persons of Slovakia using high-voltage agarose gel electrophoresis with subsequent immunofixation. Five C4A alleles and three C4B alleles were detected. The gene frequencies were as follows: A2 = 0.0576, A3 = 0.7644, A4 = 0.0336, A6 = 0.0625, AQ0 = 0.817, B1 = 0.7836, B2 = 0.1009, BQ0 = 0.1153. The C4AQ0 and C4BQ0 alleles established by densitometry appeared in the Slovak population in 16.34% and 23.07%, respectively.
Staneková
D
D
Department of Microbiology and Immunology, Medical Faculty, Commenius University, Bratislava.
Starsia
Z
Z
Valúch
J
J
D000293:Adolescent; D000328:Adult; D003181:Complement C4 / Q000032:analysis / Q000235:genetics*; D015934:Complement C4a; D015935:Complement C4b; D003604:Czechoslovakia / Q000208:ethnology; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People
D003181:Complement C4; D015934:Complement C4a; D015935:Complement C4b