title: Autoantibodies against histones and actin in patients with rheumatic diseases assessed by the western blot method.
abstract: Using the Western blot method, the authors analyzed 85 sera obtained from patients with rheumatic diseases, focused on the presence of antihistones and antiactin autoantibodies. The authors detected a 32% incidence of the two investigated autoantibody specificities. In a group of 42 patients with systemic lupus erythematosus in 22 sera (52%) positive antihistone antibodies were present, whereby autoantibodies anti-H1 and anti-H2B were most frequent. In 15 sera in this group of patients (36%) antiactin autoantibodies were present.
authors.affiliation: Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Prague.
authors.forename: I
authors.initials: I
authors.lastname: Raska
authors.forename: V
authors.initials: V
authors.lastname: Petrasovicová
authors.forename: M
authors.initials: M
authors.lastname: Jarník
authors.forename: L
authors.initials: L
authors.lastname: Cebecauser
authors.forename: L
authors.initials: L
authors.lastname: Lukacovicová
authors.forename: J
authors.initials: J
authors.lastname: Lejnar
authors.forename: V
authors.initials: V
authors.lastname: Viklický
authors.forename: J
authors.initials: J
authors.lastname: Mácha
authors.forename: M
authors.initials: M
authors.lastname: Jíra
authors.forename: K
authors.initials: K
authors.lastname: Trnavský
mesh_terms: D000199:Actins / Q000276:immunology*; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D015153:Blotting, Western; D003095:Collagen Diseases / Q000276:immunology*; D006657:Histones / Q000276:immunology*; D006801:Humans
chemical_list: D000199:Actins; D001323:Autoantibodies; D006657:Histones