[The effect of myelopeptide on the functional activity of the peripheral blood leukocytes].
The authors studied the properties of myelopeptide (MP) which is a stimulant of antibody production of bone marrow origin. It is shown that MP possesses marked chemotactic activity in relation to polymorphonuclear leukocytes. MP may apparently be a regulator of cell activation by anaphylatoxins. MP intensifies lysosomal secretion by blood leukocytes. On acting on mononuclears, MP induces fibrinolytic activity which is not characteristic of this cell population under physiological conditions. A maximal effect is achieved with MP concentration of 10 micrograms/ml. The possibility of clinical application of MP may therefore be expanded because the agent has an effect not only on processes of antibody production, but possesses a wider action, being, evidently, a mediator providing for immune intensification of cell effector mechanisms of inflammation realization, which is important in the management of inflammation in immunodeficiency.
Podosinnikov
I S
IS
Gurina
O P
OP
Babachenko
I V
IV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001853:Bone Marrow / Q000276:immunology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005342:Fibrinolysis / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects* / Q000502:physiology; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000276:Adjuvants, Immunologic; D009842:Oligopeptides; D010455:Peptides; C048617:myelopeptides
Vliianie mielopeptida na funktsional'nuiu aktivnost' leĭkotsitov perifericheskoĭ krovi.