Restoration of serotonergic innervation underlies the behavioral effects of raphe grafts.
It has been previously demonstrated that an embryonic raphe grafted into a serotonin-depleted hippocampus restores normal serotonin innervation of the hippocampus and behaviors associated with serotonin. To test the possibility that the behavioral effects of these grafts result from non-specific actions of the grafted tissue or the grafting procedure itself, we compared raphe grafts with septal grafts, in serotonin-depleted rats. We also compared the effects of a serotonin synthesis inhibitor, p-chlorophenylalanine, on the behavior of normal, serotonin-depleted and raphe-grafted rats. The results indicate that the bulk of behavioral effects of raphe grafts are due to the serotonergic nature of the graft.
Richter-Levin
G
G
Center for Neuroscience, Weizmann Institute, Rehovot, Israel.
Segal
M
M
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D016380:Brain Tissue Transplantation / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*
D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D012601:Scopolamine