[The detection of streptococci, the study of their immunobiological properties and the determination of lipoproteinase antibodies and anti-immunoglobulins in patients with acute rheumatic fever].
Bacteriological confirmation of the presence of group A Streptococcus (GAS) in patients with acute rheumatic fever (ARF) by means of the express method was achieved only in 15.1% of the cases and the positive growth of the culture was observed only in 12.1%. Streptococci isolated from the patients showed a low IgG-Fc receptor activity just as in the negative control. The blood serum of patients exhibited the presence of antibodies to 18 OF-serotypes among which serotypes 2, 4, 22, 28, 48, 68, 75, 77, 78, PT 2841 prevailed; their content fluctuated from 12.5 to 48.4%. There were no differences between the nature of distribution of the given antibodies depending on the presence and level of ASL-O in the blood and the presence of concomitant chronic tonsillitis. Antibodies to IgG in titres 1:10-1:40 were revealed in the blood of only 18.1% of the patients; there was some dependence of the frequency of their detection on the markedness of carditis and the presence of cardiac defects.
Dzhuzenova
B S
BS
Nasonova
V A
VA
Iontova
I M
IM
Burova
L A
LA
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D000907:Antibodies, Bacterial / Q000097:blood*; D000918:Antibody Specificity / Q000276:immunology; D000989:Antistreptolysin / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D010614:Pharynx / Q000382:microbiology; D011961:Receptors, Fc / Q000276:immunology; D012213:Rheumatic Fever / Q000276:immunology / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000145:classification / Q000276:immunology / Q000302:isolation & purification*; D014069:Tonsillitis / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D011961:Receptors, Fc; D000989:Antistreptolysin
Vyiavlenie streptokokkov i izuchenie ikh immunobiologicheskikh svoĭstv, opredelenie antitel k lipoproteinaze i antiimmunoglobulinov u bol'nykh ostroĭ revmaticheskoĭ likhoradkoĭ.