title: Inhibition of tumor-promoter-enhanced 3H-choline incorporation into cellular phospholipids by phloroglucinol derivatives from Mallotus japonicus.
abstract: The MeOH and CHCl3 extracts of the pericarps of Mallotus japonicus showed potential anti-tumor-promoter activity. Seven constituents of the CHCl3 extract and two derivatives from the most abundant constituent, mallotojaponin, markedly inhibited the incorporation of 3H-choline into phospholipids of C3H101/2 cells enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter.
authors.affiliation: Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Arisawa
authors.forename: A
authors.initials: A
authors.lastname: Fujita
authors.forename: N
authors.initials: N
authors.lastname: Morita
authors.forename: T
authors.initials: T
authors.lastname: Okuyama
authors.forename: H
authors.initials: H
authors.lastname: Nishino
mesh_terms: D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D002794:Choline / Q000378:metabolism*; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism*
chemical_list: D016588:Anticarcinogenic Agents; D010743:Phospholipids; D010696:Phloroglucinol; D002794:Choline