title: High-dose applications of gadolinium chelates in magnetic resonance imaging.
abstract: Administration of gadolinium chelates at doses greater than 0.1 mmol/kg IV can potentially improve both lesion detection and the assessment of tissue perfusion. Preliminary results are presented in clinical patients and two animal models. In human intracranial metastatic disease, administration of 0.3 (cumulative dose) mmol/kg gadoteridol (Gd HP-DO3A) has permitted detection of additional lesions not visualized at 0.1 mmol/kg. In a rabbit model of focal liver disease, 0.5 mmol/kg IV provided superior enhancement of both normal parenchyma and lesion rim compared to doses of 0.25 and 0.1. Dynamic imaging (T1-weighted turbo-FLASH) immediately following bolus injection of 0.5 mmol/kg permitted direct visualization (on unsubtracted images) of an acute perfusion defect in the cat brain not visible on conventional T1- and T2-weighted scans.
authors.affiliation: Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky Medical Center, Lexington 40536.
authors.forename: V M
authors.initials: VM
authors.lastname: Runge
authors.forename: J E
authors.initials: JE
authors.lastname: Kirsch
authors.forename: G S
authors.initials: GS
authors.lastname: Thomas
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis; D002415:Cats; D002544:Cerebral Infarction / Q000175:diagnosis; D003287:Contrast Media; D005682:Gadolinium; D006571:Heterocyclic Compounds; D006801:Humans; D008100:Liver Abscess / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds; D011817:Rabbits
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium