[Specific plasma sorption of proteinases--a new approach to the treatment of acute pancreatitis].
The authors treated destructive forms of acute pancreatitis for the first time by means of specific plasma sorption of proteinases with the use of a proteinase plasma sorbent which is an acid-stable proteinase inhibitor immobilized on sepharose (ASI-Sepharose). Specific plasma sorption of proteinases on ASI-Sepharose was applied to the treatment of 29 patients with various forms of acute destructive pancreatitis. At the end of specific plasma sorption procedure the activity of blood plasma proteolytic enzymes in the patients reduced by 60-75%, which was attended by marked improvement of the condition in most cases; aggravation of the patients' condition was not encountered. The mortality in this group was 20.7% and was due to complications occurring during the development of the main disease. The mortality rate among patients treated by specific proteinase plasma sorption is much lower than that recorded in the USSR for destructive forms of acute pancreatitis which ranges from 30 to 75%.
Malinovskiĭ
N N
NN
Brekhov
E I
EI
Ogloblina
O G
OG
Kalinnikov
V V
VV
Konovalov
G A
GA
Privalov
G V
GV
Belova
L A
LA
Denisov
A Iu
AIu
Starostenko
A V
AV
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002918:Chymotrypsin / Q000097:blood* / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000097:blood* / Q000302:isolation & purification; D010195:Pancreatitis / Q000201:enzymology / Q000209:etiology / Q000628:therapy*; D016060:Sorption Detoxification / Q000379:methods*; D014357:Trypsin / Q000097:blood* / Q000302:isolation & purification; D000514:alpha 1-Antichymotrypsin / Q000627:therapeutic use*; D000515:alpha 1-Antitrypsin / Q000627:therapeutic use*
D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D002918:Chymotrypsin; D010196:Pancreatic Elastase; D014357:Trypsin
Spetsificheskaia plazmosorptsiia proteinaz--novyĭ podkhod k lecheniiu ostrogo pankreatita.