[Blood plasma diene conjugates during the stimulation and inhibition of lipid peroxidation in dogs with different forms of healing in experimental myocardial infarct].
In experiments on 45 dogs with a model of normo-, hyper-, and hyporeactive myocardial infarction, (MI) lipid peroxidation (LP) was stimulated by ultraviolet irradiation of autologous blood and inhibited by alpha-tocopherol acetate. It is shown that changes of LP are characteristic of uncomplicated healing of normoreactive MI. Hyperactivation of LP in hyperreactive MI and its hypoactivation in hyporeactive MI are among the factors of complication of its healing by postinfarction aneurysm of the heart. LP modulation consisting in bringing its changes in conformity with those in uncomplicated forms of the disease facilitates normal MI healing with the formation of a postinfarction scar. Antioxidants are indicated in hyperreactive MI, and LP activation by means of stimulators is recommended in hyporeactive MI.
Sokrut
V N
VN
Iabluchanskiĭ
N I
NI
Zhdaniuk
Iu I
IuI
Libman
T Ia
TIa
D000818:Animals; D001769:Blood / Q000528:radiation effects; D001804:Blood Transfusion, Autologous; D004285:Dogs; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008054:Lipid Peroxides / Q000097:blood*; D008070:Lipopolysaccharides / Q000009:adverse effects; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000628:therapy; D011749:Pyrogens / Q000009:adverse effects; D013997:Time Factors; D024505:Tocopherols; D014467:Ultraviolet Therapy; D014810:Vitamin E / Q000031:analogs & derivatives / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects / Q000528:radiation effects; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D008054:Lipid Peroxides; D008070:Lipopolysaccharides; D011749:Pyrogens; C009136:pyrogenal; D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols
Dienovye kon''iugaty plazmy krovi pri stimuliatsii i ingibirovanii perekisnogo okisleniia lipidov u sobak s razlichnymi formami zazhivleniia éksperimental'nogo infarkta miokarda.