[The histopathological effects of different treatments on lung tissue of mice pretreated with cyclophosphamide and steroids in experimental E. coli sepsis].
The incidence of gram-negative bacteremia is significantly increasing in recent years by the wide-spread use of cytotoxic and immunosuppressive drugs. Although, the effective antimicrobial drugs are being used in treatment, the mortality rate is still high. In this study, we searched for the histopathological changes occurring on lung tissue in E. coli sepsis, and their severity in different models. Microscopically, all the specimens were examined by the presence of interstitial and peribronchiolar inflammation, congestive atelectasis, and emphysema. The differences between the ratios of histopathological changes in treatment subgroups were not statistically significant. However, the ratio of interstitial and peribronchiolar inflammation and emphysema was significantly decreased in mice received cyclophosphamide, when compared with control group. Besides, the ratio of peribronchiolar inflammation was significantly increased in mice received steroid when compared with control group.
Düzcan
E
E
Cumhuriyet Universitesi, Fakültesi Patoloji Anabilim Dali, Sivas.
Bakir
M
M
Dökmetaş
I
I
Doğanay
M
M
Güneş
H
H
D000818:Animals; D016470:Bacteremia / Q000188:drug therapy / Q000473:pathology*; D002443:Ceftriaxone / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000009:adverse effects*; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000473:pathology*; D007165:Immunosuppression Therapy; D008168:Lung / Q000473:pathology*; D008775:Methylprednisolone / Q000009:adverse effects; D051379:Mice; D013256:Steroids / Q000009:adverse effects*
D013256:Steroids; D002443:Ceftriaxone; D003520:Cyclophosphamide; D008775:Methylprednisolone
Siklofosfamid ve steroid verilen farelerde oluşturulan deneysel E. coli sepsisinde uygulanan farkli tedavilerin akciğer histopatolojisi üzerine etkileri.