The magnetic properties of some materials affecting MR images.
We have compared the magnetic properties of various types of materials known to affect MR images. The materials compared were: (i) MR contrast agents based on chelates of paramagnetic metals (Gd-DTPA, Dy-DTPA); (ii) biological forms of iron (horse spleen ferritin and deoxyhemoglobin); and (iii) a superparamagnetic iron oxide (AMI-25). The properties compared were the magnetic susceptibility and the magnetization. The magnetization and susceptibility of superparamagnetic AMI-25 are far larger than that of ferritin or low molecular weight, paramagnetic chelates. Superparamagnetic iron oxide colloids, like AMI-25, are a uniquely powerful class of magnetic materials.
Josephson
L
L
Advanced Magnetics, Inc., Cambridge, Massachusetts 02138.
Bigler
J
J
White
D
D
D000818:Animals; D003287:Contrast Media; D003911:Dextrans; D005293:Ferritins; D052203:Ferrosoferric Oxide; D019786:Gadolinium DTPA; D006454:Hemoglobins; D006801:Humans; D007501:Iron; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D009942:Organometallic Compounds; D010087:Oxides; D004369:Pentetic Acid / Q000031:analogs & derivatives
D003287:Contrast Media; D003911:Dextrans; D006454:Hemoglobins; D058185:Magnetite Nanoparticles; D009942:Organometallic Compounds; D010087:Oxides; D004369:Pentetic Acid; D005293:Ferritins; C100003:deoxyhemoglobin; C055865:dysprosium DTPA; D007501:Iron; C065507:ferumoxides; D019786:Gadolinium DTPA; D052203:Ferrosoferric Oxide