Androgenic control of hepatic mitochondrial metabolism in an apoda, Gegenophis carnosus (Beddome).
In vivo administration of testosterone significantly stimulated the activities of cytochrome oxidase, alpha-glycerophosphate dehydrogenase (alpha-GPDH), succinate dehydrogenase (SDH) and adenosine triphosphatase (Mg2+ ATPase), in mitochondria isolated from the liver of G. carnosus. Administration of dehydroepiandrosterone and androstenedione while significantly stimulated the activities of cytochrome oxidase and alpha-GPDH, did not change that of SDH and Mg2+ ATPase. Simultaneous injections of testosterone and actinomycin D or chloramphenicol prevented the testosterone-stimulated activities of all the oxidative enzymes studied. The results clearly document the important stimulatory role of androgens in the regulation of hepatic mitochondrial metabolism in G. carnosus.
Sutharama
K K
KK
Department of Zoology, University of Kerala, Kariavattom, Trivandrum, India.
Peter
M C
MC
Oommen
O V
OV
D000663:Amphibians; D000818:Animals; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D013739:Testosterone / Q000502:physiology*
D011500:Protein Synthesis Inhibitors; D013739:Testosterone