[Effects of pseudolaric acid B on blood flows of endometrium and myometrium in pregnant rats].
Effects of pseudolaric acid B (PB) on endo- and myo-metrial blood flows were measured by hydrogen gas clearance technique in 336 pentobarbital-anesthetized rats divided into control and 2 medicated groups (ig PB 20 and 30 mg.kg-1 on d 7-9 of pregnancy). Measurements of endo- and myo-metrial blood flows were done on d 7-14 of pregnancy. Results showed that the endo- and myo-metrial blood flows were reduced by 33-66% and 30-65% respectively, vs ig 1% CMC 0.5 ml (P less than 0.01). Uterine weight during d 10-14 of pregnancy stopped gain. The systemic arterial pressure remained relatively unchanged. It is concluded that PB causes a significant decrease of blood flow in both endo- and myometrium, which is accounted as the most important cause of embryo's death.
Wang
W C
WC
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai.
Gu
Z P
ZP
Koo
A
A
Chen
W S
WS
D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology*; D000818:Animals; D004224:Diterpenes / Q000494:pharmacology*; D004717:Endometrium / Q000098:blood supply*; D005260:Female; D009215:Myometrium / Q000098:blood supply*; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D014599:Uterus / Q000033:anatomy & histology
D000020:Abortifacient Agents, Nonsteroidal; D004224:Diterpenes; C058391:pseudolaric acid B