[Fibrinolytic treatment with urokinase and streptokinase for recurrent thrombosis in two valve prostheses for the aortic and mitral valves during pregnancy].
The authors report a case of a patient who had two episodes of valvular thrombosis successfully treated with fibrinolysis using urokinase and streptokinase. They emphasise how efficient these treatments are in spite of the gravity of the initial picture and also point out the dangers and difficulties that can occur because of the risk of haemorrhage in pregnancy, and particularly during delivery and post-partum. They show once more that the treatment is harmless for the fetus. They conclude that using fibrinolytic treatment should be considered first when there is great danger to the patient, and the advantages and disadvantages of thrombolysis should be weighed up.
Tissot
H
H
Maternité C, Hôpital Pellegrin, Bordeaux.
Vergnes
C
C
Rougier
P
P
Bricaud
H
H
Dallay
D
D
D000328:Adult; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000601:surgery; D002986:Clinical Trials as Topic; D016903:Drug Monitoring; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008946:Mitral Valve Stenosis / Q000150:complications / Q000601:surgery; D011183:Postoperative Complications / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D012008:Recurrence; D013300:Streptokinase / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D013300:Streptokinase; D014568:Urokinase-Type Plasminogen Activator
Traitement fibrinolytique par urokinase et streptokinase d'une thrombose récidivante sur double prothèse valvulaire aortique mitrale au cours de la grossesse.