[Islet transplantation in the treatment of diabetes mellitus: the challenges to the transplant of rejection and recurrent autoimmunity].
The success of islet transplantation for therapy of spontaneous diabetes mellitus depends on two immune responses of the recipient. The rejection of foreign tissue plays a major role in islet transplantation and can successfully be prevented by different immunomodulation in animals. In spontaneous diabetes the islet transplant can also be destroyed by the recurrent autoimmune insulitis. We describe, in which experiments recurrence occurred. We also demonstrate the influence of the donor-host combination on the immune attack and the possibilities to prevent the destruction of transplanted islets in animals. An outlook on the clinical situation is given.
Wöhrle
M
M
Medizinische Klinik III und Poliklinik, Universität Giessen.
Bretzel
R G
RG
Federlin
K
K
D015551:Autoimmunity; D003920:Diabetes Mellitus / Q000276:immunology / Q000601:surgery*; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D008285:Major Histocompatibility Complex; D012008:Recurrence
Inseltransplantation in der Behandlung des Diabetes mellitus: Die Bedrohung des Transplantats durch Abstossung und Autoimmunzerstörung.