title: Effect of clenbuterol on contractile response in periurethral striated muscle of rabbits.
abstract: The effect of clenbuterol, a selective beta 2-adrenoceptor agonist, on isolated periurethral striated muscle preparations from rabbits has been investigated. The periurethral striated muscle produced a contraction in response to field stimulation. An application of clenbuterol resulted in a dose-dependent potentiation of the field stimulation-induced contraction. This potentiation was antagonized by propranolol and was greater than that of isoproterenol, suggesting a beta 2-agonistic action.
authors.affiliation: Pharmacological Research Department, Teijin Institute for Bio-Medical Research II, Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Kishimoto
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: Y
authors.initials: Y
authors.lastname: Okamiya
authors.forename: K
authors.initials: K
authors.lastname: Hoshina
authors.forename: T
authors.initials: T
authors.lastname: Takeshita
mesh_terms: D000818:Animals; D002976:Clenbuterol / Q000494:pharmacology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D014521:Urethra / Q000187:drug effects* / Q000502:physiology
chemical_list: D011433:Propranolol; D007545:Isoproterenol; D002976:Clenbuterol