[Human immunodeficiency virus infection in hemophiliacs: prevalence and current clinical situation].
The prevalence of HIV-antibody was studied in a cohort of 156 haemophiliacs controlled since before 1986. Ninety four patients (60%) were HIV-seropositive, and all of them had been previously treated with non-heated factor concentrates. Seroprevalence was 50% by 1983. Evidence for previous negative results was only available in 19 seropositive patients and all of them seroconverted before 1985. For the 148 patients exposed to non-heat treated factor concentrates, severe haemophiliacs and those with factor consumption greater than 100 x 10(3) had the maximal rate of seropositivity (81% and 75% respectively, p less than 0.005). Fifteen patients developed AIDS (10% of the HIV-positive), 12 of which have died. HIV infection has a high prevalence and it has become the most important cause of death in our haemophiliacs.
Lorenzo
J I
JI
Unidad de Coagulopatías Congénitas de la Comunidad Valenciana, Hospital La Fe.
Molina
R
R
Arilla
M J
MJ
Dasí
M A
MA
Monteagudo
E
E
Aznar
J A
JA
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005169:Factor VIII / Q000009:adverse effects; D015658:HIV Infections / Q000635:transmission*; D015528:HIV Seroprevalence; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology
D005169:Factor VIII
Infección por el virus de la inmunodeficiencia humana en hemofílicos: prevalencia y situación clínica actual.