Structure and synthesis of nectrisine, a new immunomodulator isolated from a fungus.
The structure of a novel immunomodulator, nectrisine (1), has been elucidated on the basis of chemical and spectroscopic evidence. Its absolute stereochemistry was predicted on the basis of the dibenzoate chirality rule and finally confirmed by a synthesis from D-glucose.
Kayakiri
H
H
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Nakamura
K
K
Takase
S
S
Setoi
H
H
Uchida
I
I
Terano
H
H
Hashimoto
M
M
Tada
T
T
Koda
S
S
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D006999:Hypocreales / Q000737:chemistry*; D050113:Imino Furanoses; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D050113:Imino Furanoses; D011759:Pyrrolidines; C055825:nectrisine