Effect of kainic acid injected into raphe dorsal nucleus on sleep stages in cats.
Early (up to 5 h) and late (up to 65 days) effects of kainic acid (KA) injected into raphe dorsal nucleus (NRD) at two doses, 4 and 12 nmol, on waking-sleep stages in cats were studied. Slow-wave sleep (SWS-1 and SWS-2) and rapid eye movement sleep (REM) were strongly reduced or even completely suppressed, while waking stage, especially quiet waking stage (W-2), was significantly increased during the first 5 h after the injection. The effect was much more pronounced after injection of KA at a dose of 12 nmol. These changes in sleep stages gradually subsided and starting from the first-third day up to the 65th day after injection of KA, sleep was completely normal. The effects were interpreted as reflecting the action of KA first as a strong excitant--when a suppression of sleep was established, and then as a toxic substance with respect to NRD cells--when sleep restored to normal. These results suggest that raphe dorsal nucleus is not essential for triggering or maintenance of sleep.
Moyanova
S
S
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
Riche
D
D
D000818:Animals; D002415:Cats; D004568:Electrodiagnosis; D007267:Injections; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D011903:Raphe Nuclei / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D012894:Sleep Stages / Q000187:drug effects* / Q000502:physiology
D007608:Kainic Acid