[Point mutation of c-Ha-ras oncogene in oral cancers].
After sub-sequence of c-Ha-ras oncogene in 11 Chinese oral cancers was amplified with in vitro DNA amplification technique, G----T mutation of c-Ha-ras oncogene at codon 12 was detected by specific mutated oligonucleotide probe, resulting in point mutation of c-Ha-ras oncogene at codon 12 in 4 out of 11 oral cancers which shows that c-Ha-ras oncogene is one of the genes associated with the development and progression of oral cancers, and point mutation may lead to activation of c-Ha-ras oncogene.
Liu
X F
XF
Department of Biochemistry and Molecular Biology, Hubei Medical College.
D001483:Base Sequence; D003062:Codon / Q000235:genetics; D005784:Gene Amplification; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009062:Mouth Neoplasms / Q000235:genetics*; D009154:Mutation; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction
D003062:Codon; D015345:Oligonucleotide Probes