A role of mesangial dysfunction in the development of diabetic nephropathy.
The pathogenic mechanism of diabetic nephropathy has been extensively investigated, and the significance of alteration in glomerular hemodynamics or mesangial cell metabolism has been recently clarified. It is expected that in the near future these pathologically important alterations can be corrected, and the development diabetic nephropathy can be halted.
Shigeta
Y
Y
Third Department of Medicine, Shiga University of Medical Science, Ohtsu.
Kikkawa
R
R
D000818:Animals; D001160:Arterioles / Q000503:physiopathology; D001485:Basement Membrane / Q000473:pathology; D003928:Diabetic Nephropathies / Q000209:etiology*; D005919:Glomerular Filtration Rate; D005920:Glomerular Mesangium / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D010539:Permeability