Supersensitivity to isoprenaline induced in cultured neonatal rat heart cells by certain eicosatetraenoic acids.
Among a number of racemic eicosatetraenoic acids (HETEs) investigated, 15-R/S HETE and 11-R/S-HETE were the only ones that enormously potentiated the chronotropic action of isoprenaline on neonatal rat heart myocytes in rocked culture. The effect of the 15-R/S-HETE was exclusively due to the S isomer.
Wallukat
G
G
Institut für Herz-Kreislauf-Forschung, Berlin-Buch, Germany.
Kuehn
H
H
Wollenberger
A
A
D000818:Animals; D000831:Animals, Newborn; D001095:Arachidonic Acids / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D007545:Isoproterenol