[The effect of hydra peptide morphogen on the levels of beta-endorphin and some blood and adrenal hormones in albino rats].
The influence of PMH on the level of beta-endorphin and some hormones of blood and adrenal glands was studied. The dose A (10 mkg/kg) and dose W (100 mkg/kg) of PMH were used in our experiments. Earlier it has been discovered, that PMH in such doses stimulated the processes of cell division in 24 hours since the moment of injection. The stimulation was dose-dependent. Within 24 hours PMH in A dose decreased the concentration of beta-endorphin in the blood 2.7-fold, ad in dose W increased it 2 times. The level of corticosterone in blood and adrenal glands after the injection of PMH in dose A exceeded the control data trustworthy in 4 and 24 hours since the moment of injection. In dose B in 4 hours 1.5-fold reduction of corticosterone concentration took place in the blood. Increase in epinephrine level in adrenal glands was observed after PMH administration in two doses. Content of T3 increased in 4 hours after PMH injection in dose B. The role of hormonal changes in stimulating cell division accompanied by PMH injection is discussed. The data received show that PMH influences directly proliferative processes.
Murzina
N B
NB
Khomichuk
A Iu
AIu
Timoshin
S S
SS
Obukhova
G G
GG
Anosova
O A
OA
Berezina
G P
GP
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood; D006728:Hormones / Q000097:blood*; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D001615:beta-Endorphin / Q000378:metabolism*
D006728:Hormones; D009479:Neuropeptides; D001615:beta-Endorphin; C032522:head activator peptide; D011761:Pyrrolidonecarboxylic Acid; D003345:Corticosterone
Vliianie peptidnogo morfogena gidry na uroben' beta-éndorfina i nekotorykh gormonov krovi i nadpochechnikov belykh krys.