title: Anti-aldosteronergic effect of torasemide.
abstract: The diuretic actions of torasemide and furosemide were studied in normotensive rats and in deoxycorticosterone acetate (DOCA)-saline-loaded hypertensive rats. Torasemide (0.3-3 mg/kg) and furosemide (3-30 mg/kg) had a dose-dependent and significant diuretic action in normotensive rats. Potassium retention was only observed in the case of torasemide. Torasemide also had a dose-dependent and significant diuretic action in DOCA-saline-loaded hypertensive rats, whereas furosemide did not. Higher doses of torasemide (10 mg/kg) and furosemide (100 mg/kg) increased both plasma renin activity and aldosterone concentration in normotensive rats in a similar manner. In vivo aldosterone receptor binding was determined to test the possible anti-aldosteronergic effect of torasemide. Torasemide inhibited the binding of aldosterone to its receptor in the cytoplasmic fraction of rat kidney in a dose-dependent manner, while furosemide produced no effect. These results suggest strongly that an anti-aldosteronergic action of torasemide contributes to producing less kaliuresis.
authors.affiliation: Central Research Laboratory, Green Cross Corporation, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Uchida
authors.forename: K
authors.initials: K
authors.lastname: Yamanaga
authors.forename: M
authors.initials: M
authors.lastname: Nishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtaki
authors.forename: H
authors.initials: H
authors.lastname: Kido
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000284:Administration, Oral; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D013449:Sulfonamides / Q000494:pharmacology*; D000077786:Torsemide
chemical_list: D004232:Diuretics; D013449:Sulfonamides; D000450:Aldosterone; D005665:Furosemide; D012083:Renin; D000077786:Torsemide