title: Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease.
abstract: Formalin-fixed paraffin-embedded hippocampal sections of brains with early-onset and late-onset Alzheimer's disease were studied immunohistochemically with antisera against cathepsin D and cathepsin B. In addition to the staining of neuronal perikarya, some of the senile plaques visualized by Bielshowsky silver staining and some of reactive astrocytes were positively stained with the antisera against cathepsin D and cathepsin B in brains with Alzheimer's disease. Abnormal localization of cathepsin D and cathepsin B immunoreactivity in neuronal perikarya was observed in brains with early-onset Alzheimer's disease. These findings demonstrate that the distribution of lysosomal proteases was altered in brains with Alzheimer's disease, suggesting the primary and/or secondary involvement of the lysosomal proteases in the pathological process of Alzheimer's disease.
authors.affiliation: Department of Neuropsychiatry, Osaka University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Hattori
authors.forename: K
authors.initials: K
authors.lastname: Tada
authors.forename: S
authors.initials: S
authors.lastname: Hariguchi
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology* / Q000473:pathology; D001253:Astrocytes / Q000201:enzymology; D001921:Brain / Q000201:enzymology* / Q000473:pathology; D002401:Cathepsin B / Q000032:analysis*; D002402:Cathepsin D / Q000032:analysis*; D006801:Humans; D008247:Lysosomes / Q000201:enzymology; D009474:Neurons / Q000201:enzymology
chemical_list: D002401:Cathepsin B; D002402:Cathepsin D