Inhibition of human immunodeficiency virus type I replication by derivatives of gossypol.
Gossypol (I) and its derivatives gossylic nitrile-1,1'-diacetate (II), gossylic iminolactone (III) and gossylic lactone (IV) inhibit the replication of human immunodeficiency virus type 1 in vitro in the order III greater than I greater than II,IV, indicating that derivatives of gossypol can retain antiviral activities. All of the derivatives are less cytotoxic than gossypol.
Royer
R E
RE
Department of Biochemistry, University of New Mexico School of Medicine, Albuquerque 87131.
Mills
R G
RG
Deck
L M
LM
Mertz
G J
GJ
Vander Jagt
D L
DL
D000998:Antiviral Agents / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006072:Gossypol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; C073920:gossylic lactone; C073919:gossylic iminolactone; C073921:gossylic nitrile-1,1'-diacetate; D006072:Gossypol