Preliminary evidence for lipid peroxidation and changes in pro-oxidant status in brain tissue and blood in ethanol intoxicated rats.
A single dose of ethanol to rats (6 g ethanol/kg body weight) resulted in an increase of lipid-peroxidation in brain, a decrease of anti oxidant enzyme activity in blood serum and alteration in red cell membrane permeability, possibly in an excess of oxygen derived free radicals and physical interaction with membranes.
Mihăilescu
I
I
Department of Biochemistry, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Mohora
M
M
Dinu
V
V
D000435:Alcoholic Intoxication / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol