Sterol composition of nystatin-resistant Candida maltosa mutants.
Composition of sterol fractions of nystatin-resistant Candida maltosa strains was determined. Using UV-spectrometry, TLC and GLC-MS it was demonstrated that resistance to nystatin is connected with the composition alterations of yeast cell sterols. Block of different stages of ergosterol biosynthesis was revealed in some mutants, viz. C-24-transmethylation, delta 8----delta 7-isomerization, 14 alpha-demethylation, C-5(6)-dehydrogenation, reduction of C-14(15) and C-24(28) double bonds.
Mikhailova
N P
NP
All-Union Institute of Plant Material Hydrolysis, Leningrad, USSR.
Sorokoletova
E F
EF
Durasova
E N
EN
Vyunov
K A
KA
Shapovalov
O I
OI
D002175:Candida / Q000737:chemistry* / Q000187:drug effects / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics; D016296:Mutagenesis; D009761:Nystatin / Q000494:pharmacology*; D013261:Sterols / Q000737:chemistry*
D013261:Sterols; D009761:Nystatin