title: Treatment of pyoderma gangrenosum with cyclosporin A.
abstract: Two patients with recalcitrant pyoderma gangrenosum were treated with oral cyclosporin A (5 mg/kg body-weight/day). Healing of the lesions was achieved in Patient 1 within 1 month of starting treatment, but new areas of ulceration appeared when the dose was reduced to 3 mg/kg body-weight/day. The ulcers showed marked improvement by 3 weeks after the start of treatment in Patient 2 and remained inactive at a maintenance dosage of 100 mg/day, but there was no change in the associated seronegative arthritis. A steroid-sparing effect of CyA was evident in both patients. It is suggested that a lower dose of cyclosporin A than doses used previously in the treatment of pyoderma gangrenosum may be equally effective.
authors.affiliation: Department of Dermatology, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Soria
authors.forename: F
authors.initials: F
authors.lastname: Allegue
authors.forename: M
authors.initials: M
authors.lastname: Martin
authors.forename: A
authors.initials: A
authors.lastname: Ledo
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011711:Pyoderma / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012883:Skin Ulcer / Q000188:drug therapy* / Q000473:pathology
chemical_list: D016572:Cyclosporine