HLA association of idiopathic Peyronie's disease: an indication of autoimmune phenomena in etiopathogenesis?
HLA typing for class I and class II antigens was done in 52 unrelated patients suffering from idiopathic Peyronie's disease. The controversially discussed association with the HLA-B7 cross-reacting group could not be confirmed. Marked deviations of antigen frequencies were observed for HLA-A1, B8, Cw7, DR3 and DQw2 compared to healthy local controls. After correction of p-values, A1 (pc less than 0.05) and DQw2 (pc less than 0.01) remained significant. A possible association of Peyronie's disease with markers of the HLA-A1, B8, Cw7, DR3, DQw2 haplotype, as first described here, would suggest autoimmunological factors in this disorder of otherwise unknown etiopathogenesis.
Rompel
R
R
Institute for Clinical Immunology and Transfusion Medicine, University of Giessen, FRG.
Weidner
W
W
Mueller-Eckhardt
G
G
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D048909:Diabetes Complications; D004387:Dupuytren Contracture / Q000150:complications; D005355:Fibrosis / Q000150:complications; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000150:complications / Q000235:genetics* / Q000276:immunology; D010641:Phenotype
D005819:Genetic Markers; D006680:HLA Antigens