title: Compatibility of bupivacaine and iohexol in two mixtures for paediatric regional anaesthesia.
abstract: The compatibility of bupivacaine (0.25% and 0.125% wt/vol) with iohexol 300 mg I/ml was investigated. At room temperature bupivacaine does not decompose in these mixtures over a period of 24 h. pH Values (7.10 and 7.33), clarity, osmolality (370 and 379 mOsm/kg) and buffer capacity (0.035 ml and 0.010 ml 0.1000 mol/l NaOH per 10 ml) meet requirements for epidural injection. Both mixtures are suitable for epidurography.
authors.affiliation: Department of Hospital Pharmacy, University Hospital Utrecht, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Van Asten
authors.forename: J H
authors.initials: JH
authors.lastname: Glerum
authors.forename: E R
authors.initials: ER
authors.lastname: Spaanderman
authors.forename: J
authors.initials: J
authors.lastname: Van Niekerk
authors.forename: A
authors.initials: A
authors.lastname: Van Dijk
mesh_terms: D000765:Anesthesia, Conduction; D002045:Bupivacaine / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D002648:Child; D003116:Color; D004344:Drug Incompatibility; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D007472:Iohexol / Q000737:chemistry; D009994:Osmolar Concentration; D012996:Solutions
chemical_list: D007202:Indicators and Reagents; D012996:Solutions; D007472:Iohexol; D002045:Bupivacaine