Role of surfactants in the bioavailability of intranasal insulin.
The nasal mucosa has good physiological characteristics to allow the administration through other routes presents some problems, such is the case of insulin. The presence of surfactants is necessary to get high bioavailability.
Sanchez
A
A
Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Navarra, Spain.
Ygartua
P
P
Fos
D
D
D000042:Absorption; D000281:Administration, Intranasal; D000818:Animals; D001682:Biological Availability; D001786:Blood Glucose / Q000378:metabolism; D007328:Insulin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013501:Surface-Active Agents / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D013501:Surface-Active Agents