Inhibition of Escherichia coli DNA polymerase I catalysed DNA polymerization by trans-imidazolium-bisimidazoletetrachlororuthenate(III).
The tumor-inhibiting metal complex trans-imidazolium-bisimidazoletetrachlororuthenate(III) (ICR) reacts with DNA and inhibits template-primer properties for DNA synthesis catalysed by Escherichia coli DNA polymerase I. The reaction with DNA depends on the aging (half-life 6.8 h) of the aqueous solution containing ICR. The kinetics of the reaction with DNA are reminiscent of those for cisplatin.
Holler
E
E
Institut für Biophysik und physikalische Biochemie, Universität Regensburg, Fed. Rep. of Germany.
Schaller
W
W
Keppler
B
B
D004256:DNA Polymerase I / Q000037:antagonists & inhibitors*; D004261:DNA Replication / Q000187:drug effects*; D004269:DNA, Bacterial / Q000096:biosynthesis / Q000187:drug effects; D004926:Escherichia coli / Q000201:enzymology*; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D009942:Organometallic Compounds
D004269:DNA, Bacterial; D007093:Imidazoles; D009942:Organometallic Compounds; C048589:imidazolium-bis(imidazole)tetrachlororuthenate(III); D004256:DNA Polymerase I