Cathepsin D inhibitor from potato reverses inhibition of collagen biosynthesis in wounded skin of rats with experimental diabetes.
It was found that streptozotocin-induced diabetes is accompanied by increased proteolytic activity and decreased collagen biosynthesis in rat skin wounds. External application of cathepsin D inhibitor from potatoes normalized the proteolytic activity and restored collagen biosynthesis in wounded skin of these animals.
Pałka
J
J
Department of Biochemistry, Medical Academy of Białystok, Poland.
Sobolewski
K
K
Bańkowski
E
E
D000818:Animals; D002402:Cathepsin D / Q000037:antagonists & inhibitors*; D003094:Collagen / Q000096:biosynthesis*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008297:Male; D010436:Pepstatins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000201:enzymology / Q000293:injuries / Q000378:metabolism*; D011198:Solanum tuberosum / Q000737:chemistry* / Q000201:enzymology
D010436:Pepstatins; C014195:Streptomyces pepsin inhibitor; D003094:Collagen; D002402:Cathepsin D; C031375:pepstatin