title: Evaluation of the mutagenicity of chloral hydrate in vitro and in vivo.
abstract: Chloral hydrate (CAS 302-17-0) of greater than 99.4% purity was investigated on its mutagenic potential in a series of test systems according to the current EC guidelines. There were no indications for a mutagenic potential of chloral hydrate.
authors.affiliation: Institut für Medizinische Chemie, Medizinische Hochschule Hannover, Fed. Rep. of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Leuschner
authors.forename: F
authors.initials: F
authors.lastname: Leuschner
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002697:Chloral Hydrate / Q000633:toxicity*; D002875:Chromosomes / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
chemical_list: D009153:Mutagens; D002697:Chloral Hydrate