Cytosolic calcium is normally distributed in brain synaptosomes of normal and chronic renal failure rats.
Available data indicate that the basal levels of cytosolic calcium ([Ca2+]i) varies widely in polymorphonuclear leukocytes and in thymocytes. The present study examined whether a similar phenomenon exists in other cells. We measured the basal level of [Ca2+]i in brain synaptosomes of normal and chronic renal failure (CRF) rats. We find these levels (278-439 mM) vary widely in both normal rats and in CRF animals (350-495 mM) as well. However, despite these wide variations, the values followed normal distribution in both groups of animals. The data are consistent with the proposition that the values of [Ca2+]i in many cells display wide variations among a particular species and the levels are most likely predetermined genetically for each animal.
Smogorzewski
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Division of Nephrology, University of Southern California School of Medicine, Los Angeles.
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D000818:Animals; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013574:Synaptosomes / Q000378:metabolism*
D002118:Calcium