Modified high-performance liquid chromatographic method for the determination of ganciclovir in plasma from patients with severe renal impairment.
Using the rapid and sensitive high-performance liquid chromatographic (HPLC) method previously described for the analysis of ganciclovir in plasma, we have observed an interfering peak which co-elutes with the peak of ganciclovir in plasma samples from heart-transplant patients with severe renal insufficiency. A slight modification of this method allows the separation of the two peaks. The modified HPLC method, presented in this paper, is suitable for the accurate determination of ganciclovir in plasma from patients with severe renal impairment.
Boulieu
R
R
Institut des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacie Clinique, Lyon, France.
Bleyzac
N
N
Ferry
S
S
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D015774:Ganciclovir / Q000097:blood*; D006801:Humans; D007674:Kidney Diseases / Q000097:blood*
D015774:Ganciclovir