Modulation of anticancer drug toxicity by solcoseryl.
The studies of the effect of solcoseryl on toxicity of selected anticancer drugs were performed in mice. The observed differential influence of solcoseryl was dependent on the type of anticancer drug as well as on the schedule of solcoseryl administration. The protective effect of the biostimulator was noticed exclusively against 5-FU toxicity. The results of our studies could provide possible implications for therapeutic approach.
Sołtysiak-Pawluczuk
D
D
Department of Pharmacology, Institute of Drug Research and Control, Warsaw.
Jedrych
A
A
Jastrzebski
Z
Z
Czyzewska-Szafran
H
H
Danysz
A
A
D000183:Actihaemyl / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004361:Drug Tolerance; D005472:Fluorouracil / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity; D008297:Male; D051379:Mice
D000970:Antineoplastic Agents; D000183:Actihaemyl; D005472:Fluorouracil