title: Solid phase synthesis of the fibronectin glycopeptide V(Gal beta 3GalNAc alpha)THPGY, its beta analogue, and the corresponding unglycosylated peptide.
abstract: The fibronectin fragment VTHPGY and the corresponding glycopeptides V(Gal beta 3GalNAc alpha)THPGY and V(Gal beta 3GalNAc beta)THPGY were synthesized by the FMOC/solid phase approach. FMOC derivatives of threonine, carrying O-linked, peracetylated Gal beta 3GalNAc chains were used for introduction (HOBt-mediated coupling) of the disaccharide moieties.
authors.affiliation: Department of Organic Chemistry, Stockholm University, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Lüning
authors.forename: T
authors.initials: T
authors.lastname: Norberg
authors.forename: C
authors.initials: C
authors.lastname: Rivera-Baeza
authors.forename: J
authors.initials: J
authors.lastname: Tejbrant
mesh_terms: D000595:Amino Acid Sequence; D002240:Carbohydrate Sequence; D005353:Fibronectins / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis*; D006031:Glycosylation; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis*
chemical_list: D005353:Fibronectins; D006020:Glycopeptides; D010446:Peptide Fragments; C076289:Val(galactosyl-3-galactosyl-N-acetyl)Thr-His-Pro-Gly-Tyr