title: The seal death in Danish waters 1988. 2. Virological studies.
abstract: Mass abortions and high mortality were observed in harbour seals in Danish waters during 1988. Severe pneumonia and emphysema were typical clinical and post-mortem findings. Virological studies were carried out to identify the cause of the epidemic. Although seal herpesvirus (SeHV) was isolated in 23 of 114 animals this virus was subsequently found not to be the primary cause of the disease. Following the observation of seroconversion against canine distemper virus (CDV) in diseased seals (Osterhaus & Vedder 1988) a CDV-like morbillivirus (phocine distemper virus, PDV) was identified in organs of diseased animals. It is concluded that the epidemic was caused by introduction of PDV into a highly susceptible population presumably free from morbillivirus infection. The origin of PDV remains unknown but evidence of prior morbillivirus infection has been found in arctic and antarctic seal populations.
authors.affiliation: State Veterinary Institute for Virus Research, Lindholm.
authors.forename: P
authors.initials: P
authors.lastname: Have
authors.forename: J
authors.initials: J
authors.lastname: Nielsen
authors.forename: A
authors.initials: A
authors.lastname: Bøtner
mesh_terms: D000818:Animals; D003718:Denmark / Q000453:epidemiology; D004196:Disease Outbreaks / Q000662:veterinary*; D010252:Paramyxoviridae / Q000302:isolation & purification*; D012140:Respiratory Tract Diseases / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D010253:Respirovirus Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D046048:Seals, Earless