Effect of patulin on albumin fraction of plasma proteins studied in rats.
The toxic nature of the secondary metabolite of Penicillium patulum has been studied in rats. Plasma of the experimental animals showed a decrease in protein concentration. Detailed electrophoretic studies have been carried out, to find which fraction of the plasma protein is affected. It shows clearly that albumin fraction is very much affected, while in the tissues of the liver, kidney and intestine the DNA and RNA levels are found to be increased.
Gopalakrishnan
V K
VK
Department of Biochemistry, University of Madras, India.
Sakthisekaran
D
D
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D005591:Chemical Fractionation; D004587:Electrophoresis, Agar Gel; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D008297:Male; D015394:Molecular Structure; D010365:Patulin / Q000633:toxicity*; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism*
D001798:Blood Proteins; D012709:Serum Albumin; D010365:Patulin