Intracerebral administration of alpha-tocopherol-containing liposomes facilitates behavioral recovery in rats with bilateral lesions of the frontal cortex.
Adult rats with bilateral frontal cortex lesions received intracerebral infusion of phosphatidylcholine liposomes, or D-alpha-tocopherol-enriched liposomes, delivered continuously for 7 days to the damaged cortex by subcutaneous osmotic pumps. All subjects were first tested on a delayed spatial alternation task and then, 90 days later, on a spatial navigation task in the Morris water maze. Both tests showed that brain-injured rats with alpha-tocopherol treatment were less impaired than counterparts treated with plain liposomes. Alpha-tocopherol also reduced some of the injury-induced, secondary reactive changes that typically follow damage to the frontal cortex.
Stein
D G
DG
Rutgers-State University, Institute of Animal Behavior, Newark, New Jersey.
Halks-Miller
M
M
Hoffman
S W
SW
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002552:Cerebral Ventricles / Q000473:pathology; D004337:Drug Carriers; D005625:Frontal Lobe / Q000293:injuries* / Q000473:pathology; D015918:Infusion Pumps, Implantable; D007858:Learning / Q000187:drug effects / Q000502:physiology; D008081:Liposomes; D008297:Male; D009410:Nerve Degeneration; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000473:pathology; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D004337:Drug Carriers; D008081:Liposomes; D014810:Vitamin E