title: Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers.
abstract: The effect of piperine on the bioavailability and pharmacokinetics of propranolol and theophylline has been examined in a crossover study. Six subjects in each group received a single oral dose of propranolol 40 mg or theophylline (150 mg) alone or in combination with piperine 20 mg daily for 7 days. An earlier tmax and a higher Cmax and AUC were observed in the subjects who received piperine and propranolol. It produced a higher Cmax, longer elimination half-life and a higher AUC with theophylline. In clinical practice, the enhanced systemic availability of oral propranolol and theophylline could be exploited to achieve better therapeutic control and improved patient compliance.
authors.affiliation: Department of Pharmacology and Therapeutics, Government Medical College, Jammu-Tawi, India.
authors.forename: G
authors.initials: G
authors.lastname: Bano
authors.forename: R K
authors.initials: RK
authors.lastname: Raina
authors.forename: U
authors.initials: U
authors.lastname: Zutshi
authors.forename: K L
authors.initials: KL
authors.lastname: Bedi
authors.forename: R K
authors.initials: RK
authors.lastname: Johri
authors.forename: S C
authors.initials: SC
authors.lastname: Sharma
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000470:Alkaloids; D052117:Benzodioxoles; D001682:Biological Availability; D004359:Drug Therapy, Combination; D006801:Humans; D008875:Middle Aged; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides; D011433:Propranolol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D011433:Propranolol; D013806:Theophylline; C008922:piperine