[Preventive effect of bombesin on alloxan-induced diabetes in rat].
The effect of bombesin against injury on rat islet B cells was studied in three kinds of experiments: (1). In vivo experiment, it was found that preinjection of bombesin (50 micrograms/kg, sublingual v.) could effectively prevent an increase of plasma glucose and decrease of plasma insulin in diabetic rat induced by alloxan (200 mg/kg, s.c.) (2). In vitro experiment, isolated pancreas perfusion showed that alloxan-induced (14 mmol/L) perfusion fluid inhibition of insulin secretion could be reversed by pretreatment of bombesin (10(-3) mmol/L). (3). Investigation on isolated and incubated islets demonstrated that alloxan induced decrease of insulin and somatostatin secretion and increase of glucagon secretion could be prevented by bombesin. The above-mentioned results suggest that bombesin may play an important role in the regulation of plasma glucose in diabetic rat and have a potent preventive effect against the development of diabetes.
Song
Y
Y
Department of Physiology, Beijing Medical University.
Yu
J R
JR
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001839:Bombesin / Q000627:therapeutic use*; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology / Q000517:prevention & control*; D005934:Glucagon / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D007328:Insulin; D000496:Alloxan; D005934:Glucagon; D001839:Bombesin