Effect of intraperitoneal tuftsin administration on histamine concentration in tissues of guinea-pigs.
The performed studies dealt with the effect of tuftsin (tetrapeptide Thr-Lys-Pro-Arg), a stimulator of many components of immunological reactions, exerted on histamine concentration in lungs, kidneys, liver, duodenal wall and arterial blood of guinea-pigs. Tuftsin was given intraperitoneally, in a single dose (0.5 and 1.0 mg/kg) or three times at one-hour intervals (1.0 mg/kg). It has been revealed that tuftsin alters the histamine concentration in tissues of guinea-pigs by lowering it in lungs, and by elevating it in kidneys and liver, in the latter insignificantly.
Paradowski
A
A
Department of Physiology, Pomeranian Medical Academy, Wrocław.
Rózga
M
M
Nawrocka
E
E
Siemion
I Z
IZ
D000595:Amino Acid Sequence; D000818:Animals; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008969:Molecular Sequence Data; D014018:Tissue Distribution; D014405:Tuftsin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
D006632:Histamine; D014405:Tuftsin