Corticotrophin-releasing factor and arginine vasopressin in the hypothalamo-hypophyseal portal blood of rats following high-dose glucocorticoid treatment and withdrawal.
Hypothalamo-hypophyseal portal blood was obtained from rats treated with chronic, high-dose prednisolone in the drinking water and after subsequent withdrawal of the steroid for up to 7 days. Corticotrophin-releasing factor (CRF) immunoreactivity in portal blood was reduced by treatment with prednisolone but not completely abolished. There was a rapid recovery of CRF to control values within 3 days of withdrawal of prednisolone. There was no significant change in arginine vasopressin (AVP) in portal blood over the time-course of the experiment.
Eckland
D J
DJ
Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, U.K.
Harbuz
M S
MS
Jessop
D S
DS
Lightman
S L
SL
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000097:blood / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000098:blood supply* / Q000378:metabolism; D007700:Kinetics; D008297:Male; D011168:Portal System; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014867:Water
D014867:Water; D001127:Arginine Vasopressin; D003346:Corticotropin-Releasing Hormone; D011239:Prednisolone; C021322:prednisolone hemisuccinate