Oral administration of [3H]navelbine in patients: comparative pharmacokinetics using radioactive and radioimmunologic determination methods.
[3H]Navelbine (NVB) was administered orally to two patients. Drug levels in biological fluids were monitored by radioimmunoassay (RIA) and direct radioactivity (RA) determinations. NVB absorption was rapid: maximum plasma concentrations appeared in the first 2 h after oral administrations. Pharmacokinetic parameters estimated from RIA data were in complete accordance with those obtained from i.v. injections. Bioavailability (i.v./po) estimated from RIA and RA data averaged 40.6 and 93.0%, respectively. NVB urine excretion was low. Fecal excretion remained its main elimination route. Moreover, large differences were observed in area under NVB plasma concentration-time curve (AUC) values obtained by the two methods, implying intense drug bio-transformations.
Rahmani
R
R
Laboratoire de Pharmacocinétique et Toxicocinétique, INSERM U 278, Marseille, France.
Zhou
X J
XJ
Boré
P
P
Van Cantfort
J
J
Focan
C
C
Cano
J P
JP
D000284:Administration, Oral; D000368:Aged; D000970:Antineoplastic Agents / Q000276:immunology / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000737:chemistry; D006801:Humans; D007408:Intestinal Absorption; D008875:Middle Aged; D011863:Radioimmunoassay; D014018:Tissue Distribution; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000276:immunology / Q000493:pharmacokinetics; D000077235:Vinorelbine
D000970:Antineoplastic Agents; D014747:Vinblastine; D000077235:Vinorelbine