Suspected central nervous system toxicity from inadvertent nonsteroidal antiinflammatory drug overdose.
This case illustrates a severe adverse reaction of the central nervous system involving a moderate overdose of diclofenac sodium along with therapeutic dosages of indomethacin and ibuprofen. Our patient became disoriented, hallucinated, lost consciousness, and suffered respiratory arrest after ingesting five diclofenac tablets (375 mg total), two ibuprofen tablets (400 mg total), and one indomethacin capsule (75 mg). Aggressive supportive therapy was instituted and the patient improved. She was awake, alert, and extubated in less than 24 hours with no serious sequelae.
Bright
T P
TP
Indiana University Medical Center, Indianapolis.
McNulty
C J
CJ
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000506:poisoning*; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D004008:Diclofenac / Q000008:administration & dosage / Q000506:poisoning; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000506:poisoning; D007213:Indomethacin / Q000008:administration & dosage / Q000506:poisoning; D008875:Middle Aged; D011041:Poisoning / Q000628:therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D007052:Ibuprofen; D007213:Indomethacin