title: Metoclopramide increases plasma but not cerebrospinal fluid vasopressin levels in man: study in hydrocephalic patients.
abstract: Arginine vasopressin (AVP) concentrations were determined in plasma and in cerebrospinal fluid (CSF) in 8 adult male patients suffering from hydrocephalus of various etiologies, before and after intravenous administration of 10 mg metoclopramide. Metoclopramide was able to increase the plasma (2.6 +/- 0.2 ng/l in basal conditions and 6.1 +/- 0.6 ng/l at 30 min) but not the CSF AVP levels. The results suggest that the neurons which secrete AVP into the CSF may be functionally different from those secreting into the peripheral circulation.
authors.affiliation: Department of Internal Medicine, University of Genoa, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Barreca
authors.forename: R
authors.initials: R
authors.lastname: Franceschini
authors.forename: C
authors.initials: C
authors.lastname: Siani
authors.forename: A
authors.initials: A
authors.lastname: Cataldi
authors.forename: N
authors.initials: N
authors.lastname: Francaviglia
authors.forename: C
authors.initials: C
authors.lastname: Silvestro
authors.forename: E
authors.initials: E
authors.lastname: Rolandi
mesh_terms: D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood* / Q000134:cerebrospinal fluid; D006801:Humans; D006849:Hydrocephalus / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008297:Male; D008787:Metoclopramide; D008875:Middle Aged
chemical_list: D001127:Arginine Vasopressin; D008787:Metoclopramide