title: The molecular basis of heterogeneity of hepatitis delta virus.
abstract: HDV-RNA displays genetic heterogeneity at several different levels. This heterogeneity is likely reflected in the biological properties, such as pathogenicity and evolution, of HDV. The variation and progression of the clinical picture of delta hepatitis is likely associated with the heterogeneity of the virus. The mechanism of the generation of the heterogeneity remains largely to be studied.
authors.affiliation: Department of Microbiology, Howard Hughes Medical Institute, University of Southern California, School of Medicine, Los Angeles 90033.
authors.forename: M M
authors.initials: MM
authors.lastname: Lai
authors.forename: C M
authors.initials: CM
authors.lastname: Lee
authors.forename: F Y
authors.initials: FY
authors.lastname: Bih
authors.forename: S
authors.initials: S
authors.lastname: Govindarajan
mesh_terms: D000956:Antigens, Viral / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics*; D014644:Genetic Variation; D005843:Geography; D003699:Hepatitis D / Q000382:microbiology / Q000503:physiopathology; D003698:Hepatitis Delta Virus / Q000235:genetics* / Q000302:isolation & purification; D035923:Hepatitis delta Antigens; D006801:Humans
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral; D035923:Hepatitis delta Antigens; C442244:hepatitis delta virus large antigen