Vascular permeability increase in the mouse paw during the passive anaphylaxis reaction.
Assessment of mouse paw edema induced by the passive allergic reaction was made by the previously reported dye-leakage method. The edema was induced by the injection of antiserum against ovalbumin into the paw, followed by the intravenous injection of ovalbumin 10 min before or 72 hr later. The latter reaction may be mainly mediated by heat-labile IgE. Both of the edemas were suppressed by pretreatment with mepyramine, methysergide, PAF-antagonists, or dexamethasone, and the latter suppressed by the lipoxygenase inhibitor AA-861, suggesting that histamine, serotonin, PAF, and leukotrienes are involved in exudate formation in these edemas.
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Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Yamaki
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Oh-ishi
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D000818:Animals; D002199:Capillary Permeability / Q000502:physiology*; D004487:Edema / Q000503:physiopathology; D005122:Exudates and Transudates; D005260:Female; D006632:Histamine / Q000502:physiology; D007073:Immunoglobulin E / Q000502:physiology; D007136:Immunoglobulins / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D010047:Ovalbumin; D010323:Passive Cutaneous Anaphylaxis / Q000502:physiology*; D010972:Platelet Activating Factor / Q000502:physiology; D012701:Serotonin / Q000502:physiology
D007136:Immunoglobulins; D010972:Platelet Activating Factor; D012701:Serotonin; D007073:Immunoglobulin E; D006632:Histamine; D010047:Ovalbumin