title: Susceptibility contrast imaging of cerebral blood volume: human experience.
abstract: Magnetic resonance (MR) can offer a unique window on the structure/function relationships in the brain, by utilizing the established link between tissue function, metabolism, and hemodynamics. This report focuses on recent applications of MR-based cerebral blood volume (CBV) imaging in humans. Our methodology uses high-speed "single-shot" or echo planar imaging techniques, which provide the necessary temporal resolution for mapping the rapid cerebral transit of contrast agents. These MR CBV mapping techniques have been used to study normal human brain task activation and in the clinical study of patients with brain tumors. In the latter, positron emission tomography imaging was used for functional metabolic and CBV correlation. Susceptibility contrast CBV imaging should allow us to improve our understanding of the relationship between the detailed physiology and morphology of the microvascular bed and functional attributes of the brain. These techniques can be applied to understanding fundamental questions of cognitive neuroscience and can aid in improving diagnostic sensitivity and specificity in various neuropathologies.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston 02129.
authors.forename: B R
authors.initials: BR
authors.lastname: Rosen
authors.forename: J W
authors.initials: JW
authors.lastname: Belliveau
authors.forename: H J
authors.initials: HJ
authors.lastname: Aronen
authors.forename: D
authors.initials: D
authors.lastname: Kennedy
authors.forename: B R
authors.initials: BR
authors.lastname: Buchbinder
authors.forename: A
authors.initials: A
authors.lastname: Fischman
authors.forename: M
authors.initials: M
authors.lastname: Gruber
authors.forename: J
authors.initials: J
authors.lastname: Glas
authors.forename: R M
authors.initials: RM
authors.lastname: Weisskoff
authors.forename: M S
authors.initials: MS
authors.lastname: Cohen
mesh_terms: D001921:Brain / Q000033:anatomy & histology*; D001932:Brain Neoplasms / Q000175:diagnosis*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003287:Contrast Media; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds; D004369:Pentetic Acid; D014055:Tomography, Emission-Computed; D014793:Visual Cortex / Q000033:anatomy & histology
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA