[The anxiogenic activity of phenylethylamine in the social isolation test on mice].
One-day isolation of male albino mice of SHR strain significantly increased the level of social behaviour measured by the number and total duration of active contacts (sniffings). A putative endogenous anxiogen beta-phenylethylamine (5-12.5 mg/kg) inhibited the communication like human anxiogens corazole (10 mg/kg) and caffeine (200 mg/kg). Diazepam (1 mg/kg) prevented the action of phenylethylamine, phenibut (10-50 mg/kg) exerted no effect on it. The social isolation test during studying anxiogens and anxiolytics can be performed on mice as previously on rats.
Lapin
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Slepokurov
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D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001565:Benzoates / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010433:Pentylenetetrazole / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology*; D012919:Social Behavior; D012934:Social Isolation; D014149:Tranquilizing Agents / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology
D001565:Benzoates; D004338:Drug Combinations; D010627:Phenethylamines; D014149:Tranquilizing Agents; D002110:Caffeine; D005680:gamma-Aminobutyric Acid; C025741:caffeine, sodium benzoate drug combination; D003975:Diazepam; C008842:4-amino-3-phenylbutyric acid; D010433:Pentylenetetrazole
Anksiogennaia aktivnost' fenilétilamina v teste sotsial'noĭ izoliatsii na myshakh.