Lipoprotein lipase deficiency due to long-term heparinization presenting as severe hypertriglyceridaemia in pregnancy.
A case of severe hypertriglyceridaemia presenting in the third trimester of pregnancy in a woman on long-term heparin prophylaxis is described. The hypertriglyceridaemia was attributed to impaired clearance of triglyceride-rich lipoprotein particles secondary to heparin-induced reduction in the activity of the lipolytic enzyme, lipoprotein lipase.
Watts
G F
GF
Department of Endocrinology and Chemical Pathology, United Medical School of Guy's Hospital, London, UK.
Cameron
J
J
Henderson
A
A
Richmond
W
W
D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced* / Q000201:enzymology; D008071:Lipoprotein Lipase / Q000172:deficiency*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced* / Q000201:enzymology
D006493:Heparin; D008071:Lipoprotein Lipase