Assay of 1,4-dioxane in commercial cosmetic products by HPLC.
The HPLC assay of 1,4-dioxane in a wide range of commercially available cosmetics containing polyethoxylated surfactants is described. After solid-phase extraction using Bakerbond CN- and Bakerbond C18-cartridges, samples were directly analysed on a LiChrospher CH-8 column with an acetonitrile water eluent and UV detection at 200 nm. Of the total cosmetic products investigated, 48% were found to contain 7.3-85.9 ppm of 1,4-dioxane.
Scalia
S
S
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.
Menegatti
E
E
D002851:Chromatography, High Pressure Liquid; D003358:Cosmetics / Q000032:analysis*; D004146:Dioxanes / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
D003358:Cosmetics; D004146:Dioxanes; C025223:1,4-dioxane