[The antioxidant hydroxypyridine-6 as an agent to prevent postresuscitation heart damage].
It was demonstrated in experiments on an intact organism and on an isolated isovolemically contracting rat heart that acute fatal blood loss and subsequent resuscitation cause depression of the contractile function due to extreme activation of lipid peroxidation processes and disturbed heart energy metabolism. Preliminary administration of the water soluble antioxidant oxypyridine-6 significantly reduces the heart functional metabolic disorders in the early postresuscitation period and reduces the postresuscitation mortality almost by half during the first 60 minutes after restoration to life.
Dolgikh
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VT
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000503:physiopathology / Q000517:prevention & control*; D003643:Death; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006470:Hemorrhage / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010847:Picolines; D011725:Pyridines / Q000627:therapeutic use*; D051381:Rats; D012151:Resuscitation / Q000009:adverse effects*; D013997:Time Factors
D000975:Antioxidants; D010847:Picolines; D011725:Pyridines; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Antioksidant oksipiridin-6 kak sredstvo profilaktiki postreanimatsionnykh povrezhdeniĭ serdtsa.