title: The automated modified Russell viper venom time test for the lupus anticoagulant.
abstract: Antiphospholipid antibodies, both anticardiolipin antibody and lupus anticoagulant, are associated with a hypercoagulable state, manifested as thrombotic events and pregnancy losses. Multiple coagulation tests are available for the lupus anticoagulant, but few are in wide use. The modified Russell viper venom test (RVVT) is one of several excellent tests for the lupus anticoagulant, with high sensitivity and specificity. We present an automated method for measuring the RVVT and demonstrate its reproducibility.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: M
authors.initials: M
authors.lastname: Petri
authors.forename: L
authors.initials: L
authors.lastname: Nelson
authors.forename: F
authors.initials: F
authors.lastname: Weimer
authors.forename: D
authors.initials: D
authors.lastname: Anderson
authors.forename: T
authors.initials: T
authors.lastname: Darlington
authors.forename: L
authors.initials: L
authors.lastname: Corash
mesh_terms: D001331:Automation; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D010976:Platelet Count; D011517:Prothrombin Time; D011786:Quality Control; D015203:Reproducibility of Results
chemical_list: D016682:Lupus Coagulation Inhibitor