Metabolic management of the patient with head injury.
Patients with severe head injury have a disruption in metabolic homeostasis that includes increased energy expenditure and increased protein catabolism. These changes have been suggested to occur secondary to steroid administration, immobility, and other factors. A review of investigations indicates that the head injury itself causes these metabolic changes, although steroid administration can further alter plasma amino acid changes. Altered plasma amino acid profiles after head injury may have an effect on substrate availability to the brain, bacterial translocation, and overall nitrogen balance. Patients with severe head injury have increased skeletal muscle efflux of amino acids. Lack of nutrient supplementation in these patients is associated with increased morbidity and mortality. Enteral nutrition is the preferred mode of feeding but often is not tolerated in the patient with head injury. Parenteral nutritional support can be given to these patients without worsening cerebral edema.
Young
B
B
Department of Surgery, University of Kentucky Medical Center, Lexington.
Ott
L
L
Phillips
R
R
McClain
C
C
D000596:Amino Acids / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000503:physiopathology; D001930:Brain Injuries / Q000503:physiopathology* / Q000628:therapy; D002149:Energy Intake / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D004750:Enteral Nutrition; D006801:Humans; D010289:Parenteral Nutrition, Total; D011506:Proteins / Q000378:metabolism
D000596:Amino Acids; D001786:Blood Glucose; D011506:Proteins