title: Lipoprotein lipase deficiency due to long-term heparinization presenting as severe hypertriglyceridaemia in pregnancy.
abstract: A case of severe hypertriglyceridaemia presenting in the third trimester of pregnancy in a woman on long-term heparin prophylaxis is described. The hypertriglyceridaemia was attributed to impaired clearance of triglyceride-rich lipoprotein particles secondary to heparin-induced reduction in the activity of the lipolytic enzyme, lipoprotein lipase.
authors.affiliation: Department of Endocrinology and Chemical Pathology, United Medical School of Guy's Hospital, London, UK.
authors.forename: G F
authors.initials: GF
authors.lastname: Watts
authors.forename: J
authors.initials: J
authors.lastname: Cameron
authors.forename: A
authors.initials: A
authors.lastname: Henderson
authors.forename: W
authors.initials: W
authors.lastname: Richmond
mesh_terms: D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced* / Q000201:enzymology; D008071:Lipoprotein Lipase / Q000172:deficiency*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced* / Q000201:enzymology
chemical_list: D006493:Heparin; D008071:Lipoprotein Lipase