[The combined action of the components of compound PSB-500 and its hygienic standardization in the water of reservoirs].
A multi-component composition of RSB-500 of the not strictly fixed quantitative composition as a model one and four additional mixtures of the fixed composition have been studied, as well as the character of the combined effect of its components. It has been found out, that for the composition of RSB-500 the total threshold concentration is 0.4 mg/l according to BOD, and the maximal no-effect dose is 0.27 mg/kg. Potentiation of the effect of the components is observed according to the influence on BOD, additivity--according to the degree of cumulation. Embryotoxic, gonadotoxic, mutagenic and allergic effects were not observed. The limiting degree of harmfulness is general toxic (BOD stimulation), the fourth degree of danger. It is recommended to maintain sanitary control according to nitriltrimethylphosphonic acid on the level 0.3 mg/l and phosphorous acid on the level 0.07 mg/l.
Fedorenko
V I
VI
D000818:Animals; D003252:Construction Materials / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D008452:Maximum Allowable Concentration; D051381:Rats; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*
D004338:Drug Combinations; D014874:Water Pollutants, Chemical
Kombinirovannoe deĭstvie komponentov kompozitsii PSB-500 i ee gigienicheskoe normirovanie v vode vodoemov.