title: [Ranitidine in the prevention of upper gastrointestinal tract hemorrhage following thermal injury].
abstract: This paper reports the use of Ranitidine in preventing upper gastrointestinal tract hemorrhage following thermal injury. In 12 hours after intravenous injection of Ranitidine, gastric pH was elevated from 3.25 +/- 0.26 to 5.16 +/- 0.47 (P less than 0.01) in twenty-one burn patients, with mean TBSA 62.6% +/- 17.2% (31%-87.5%), mean third degree BSA 41.4% +/- 18.3% (0-68%). The volume of gastric secretion was decreased from 15.81 +/- 4.4 ml to 2.85 +/- 0.9 ml. The free acid of gastric secretion was decreased from 25.74 +/- 4.42 mmol/L to 5.98 +/- 3.68 mmol/L (P less than 0.01). The total titratable acidity of gastric secretion was decreased from 44.76 +/- 5.76 mmol/L to 13.85 +/- 0.02 mmol/L (P less than 0.01). Three patients had occult blood in their gastric contents on admission, and it turned negative after Ranitidine therapy. However, during 1987-1988, the incidence of upper gastrointestinal tract hemorrhage of fifty-one patients with similar TBSA and third degree BSA burned was 21.6%. Changes in gastric secretion and lowered incidence of upper gastrointestinal hemorrhage after Ranitidine therapy suggest that Ranitidine may be effective in preventing upper gastrointestinal tract hemorrhage following thermal injury.
authors.affiliation: Department of Burns, Ningbo Second Hospital.
authors.forename: M Q
authors.initials: MQ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D002056:Burns / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000627:therapeutic use*
chemical_list: D011899:Ranitidine