title: A phase II study of epirubicin in breast cancer.
abstract: We evaluated the efficacy of epirubicin in a phase II trial in breast cancer, as well as its cardiac toxicity. The study was carried out on 40 female patients with advanced, metastatic, or recurrent breast cancer. The patients were grouped into two groups: group I received 30 mg/m2 epirubicin weekly, and group II 90 mg/m2 epirubicin every 3 weeks. Cardiac monitoring was by ECG, roentgenography, echocardiography and endomyocardial biopsies. Clinical results were 35.3% overall response in group I, and 50% overall response in group II. No untoward cardiac toxicities were encountered. We conclude that epirubicin is an effective agent in breast cancer with relatively little cardiac toxicity.
authors.affiliation: National Cancer Institute, Department of Medical Oncology, Cairo, Egypt.
authors.forename: N G
authors.initials: NG
authors.lastname: el Mawla
authors.forename: M R
authors.initials: MR
authors.lastname: Hamza
authors.forename: A
authors.initials: A
authors.lastname: el Khodari
authors.forename: H
authors.initials: H
authors.lastname: Khaled
authors.forename: R
authors.initials: R
authors.lastname: Gaafar
authors.forename: H
authors.initials: H
authors.lastname: el Zawahry
authors.forename: A
authors.initials: A
authors.lastname: abdel Wareth
authors.forename: M D
authors.initials: MD
authors.lastname: Dardir
authors.forename: N
authors.initials: N
authors.lastname: Habboubi
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy*; D004341:Drug Evaluation; D004452:Echocardiography; D004562:Electrocardiography; D015251:Epirubicin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D009362:Neoplasm Metastasis; D011859:Radiography
chemical_list: D015251:Epirubicin