title: Effect of linoleic acid hydroperoxide on production of matrix metalloproteinases by human skin fibroblasts.
abstract: The effect of linoleic acid hydroperoxide on in vitro production of matrix metalloproteinases (MMPs) by human skin fibroblasts was studied. The addition of linoleic acid hydroperoxide significantly increased the production of MMP-1 (tissue collagenase) and MMP-3 (stromelysin), while it rather decreased that of MMP-2 (gelatinase of 72 kDa; so-called "type IV collagenase"). The effect of lipid peroxides to alter collagen metabolism was discussed from pathogenic points of view.
authors.affiliation: Department of Pathology, Kurume University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohuchida
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaguri
authors.forename: M
authors.initials: M
authors.lastname: Morimatsu
authors.forename: H
authors.initials: H
authors.lastname: Nagase
authors.forename: K
authors.initials: K
authors.lastname: Yagi
mesh_terms: D002478:Cells, Cultured; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015151:Immunoblotting; D008041:Linoleic Acids / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000494:pharmacology*; D008666:Metalloendopeptidases / Q000096:biosynthesis*; D008856:Microscopy, Fluorescence; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
chemical_list: D008041:Linoleic Acids; D008054:Lipid Peroxides; C008285:linoleic acid hydroperoxide; D008666:Metalloendopeptidases