title: [Isoprenoide pathway and cell proliferation in the yeast Saccharomyces cerevisiae].
abstract: Yeast mutants blocked in farnesyl diphosphate (FPP) synthetase have been isolated. Their specific phenotype is likely linked to a lowering in the FPP pool required for protein prenylation. The structural gene of FPP synthetase has been isolated. Complete inactivation of FPP synthetase by gene disruption is letal for the yeast cells.
authors.affiliation: Laboratoire de Biochimie et Génétique des Microorganismes, Université de Poitiers, France.
authors.forename: L
authors.initials: L
authors.lastname: Blanchard
authors.forename: C
authors.initials: C
authors.lastname: Chambon
authors.forename: C
authors.initials: C
authors.lastname: Marcireau
authors.forename: F
authors.initials: F
authors.lastname: Karst
mesh_terms: D002455:Cell Division; D004122:Dimethylallyltranstransferase / Q000235:genetics / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology* / Q000235:genetics
chemical_list: D004122:Dimethylallyltranstransferase
vernacular_title: Voie des isoprénoïdes et prolifération cellulaire chez la levure Saccharomyces cerevisiae.