title: [The clinical efficacy of autofibronectin obtained by heparin cryoprecipitation in patients with trophic skin lesions].
abstract: The authors studied the clinical efficacy of the local external use of fibronectin obtained from autoplasma by heparin cryoprecipitation in 8 patients with immune complex pathology, paraproteinemic hemoblastoses and beta-thalassemia complicated by erosive and ulcerous skin lesions. Autofibronectin was shown to bring about complete healing of ulcerous defects within 10 to 45 days. The therapeutic approach suggested is money-saving and excludes a possibility of transmitting hepatitis B and immunodeficiency viruses by the patient.
authors.forename: S A
authors.initials: SA
authors.lastname: Vasil'ev
authors.forename: E E
authors.initials: EE
authors.lastname: Efremov
authors.forename: E V
authors.initials: EV
authors.lastname: Rybachenkova
authors.forename: T V
authors.initials: TV
authors.lastname: Savenko
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D011232:Chemical Precipitation; D003080:Cold Temperature; D004341:Drug Evaluation; D005260:Female; D005353:Fibronectins / Q000302:isolation & purification / Q000627:therapeutic use*; D006493:Heparin; D006801:Humans; D008297:Male; D008875:Middle Aged; D012883:Skin Ulcer / Q000097:blood / Q000188:drug therapy* / Q000209:etiology
chemical_list: D005353:Fibronectins; D006493:Heparin
vernacular_title: Klinicheskaia éffektivnost' autofibronektina, poluchennogo metodom geparinokriopretsipitatsii, u bol'nykh s troficheskimi porazheniiami kozhi.