title: Neutralization of kinin-releasing enzymes from viperid venoms by antivenom IgG fragments.
abstract: The activities of kinin-releasing enzymes in the venoms of Vipera xanthina xanthina, V. lebetina obtusa, V. aspis aspis, V. lebtina schweizeri, V. ammodytes ammodytes and V. berus berus were determined using a specific radioimmunoassay for kinin. The kinin-releasing activities of all the viperid venoms measured in vitro were neutralized, to varying extents, by two commercially available monospecific antivenoms in the form of F(ab')2 (Zagreb) and Fab (TAb) immunoglobin fragments, indicating a high degree of cross-neutralization of those enzymes.
authors.affiliation: Department of Chemistry and Biological Chemistry, University of Essex, Colchester, U.K.
authors.forename: A
authors.initials: A
authors.lastname: al-Joufi
authors.forename: G S
authors.initials: GS
authors.lastname: Bailey
authors.forename: K
authors.initials: K
authors.lastname: Reddi
authors.forename: D C
authors.initials: DC
authors.lastname: Smith
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D000997:Antivenins / Q000276:immunology*; D003429:Cross Reactions; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007128:Immunoglobulin Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology*; D007610:Kallikreins / Q000276:immunology / Q000378:metabolism; D007705:Kinins / Q000378:metabolism*; D009500:Neutralization Tests; D011863:Radioimmunoassay; D012756:Sheep / Q000276:immunology; D014757:Viper Venoms / Q000276:immunology*
chemical_list: D000997:Antivenins; D007140:Immunoglobulin Fab Fragments; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D007705:Kinins; D014757:Viper Venoms; D007610:Kallikreins