Pharmacokinetics of GLQ223 in rats, monkeys, and patients with AIDS or AIDS-related complex.
The pharmacokinetics of GLQ223 administered as a single short intravenous infusion to rats, monkeys, and patients with AIDS or AIDS-related complex (ARC) are presented. GLQ223 was given at a dose of 3,500 micrograms/kg of body weight to five Sprague-Dawley rats; a dose of 300 micrograms/kg was given to three cynomolgus monkeys; and doses of 1, 8, 16, 24, and 36 micrograms/kg were given to 10 patients with AIDS and 8 patients with ARC in an escalating dose design. Plasma clearance was 0.85 +/- 0.24 liter/h/kg in rats, 0.16 +/- 0.08 liter/h/kg in monkeys, and 0.13 +/- 0.07 liter/h/kg in patients with AIDS or ARC. The volume of distribution at steady state was 0.42 +/- 0.12, 0.21 +/- 0.20, and 0.18 +/- 0.50 liter/kg in rats, monkeys, and patients, respectively. The elimination half-life was 1.3 +/- 0.4, 3.7 +/- 1.5, and 3.2 +/- 1.0 h in rats, monkeys, and patients, respectively. The disposition of GLQ223 was not dose dependent within the dose range tested in patients with AIDS or ARC. Interspecies pharmacokinetic scaling resulted in a good linear correlation for plasma clearance and the volume of distribution at steady state plotted versus species body weight on a log-log scale, indicating the predictability of elimination and distribution of GLQ223 among species. Allometric equations derived may be useful for the prediction of doses and dosage regimens to be used in animal models.
Gatti
G
G
Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco 94143.
Kahn
J O
JO
Lifson
J
J
Williams
R
R
Turin
L
L
Volberding
P A
PA
Gambertoglio
J G
JG
D000386:AIDS-Related Complex / Q000378:metabolism*; D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism*; D000328:Adult; D000818:Animals; D001835:Body Weight; D006801:Humans; D007262:Infusions, Intravenous; D008252:Macaca fascicularis; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D015978:Trichosanthin / Q000097:blood / Q000493:pharmacokinetics*
D015978:Trichosanthin