[Effect of altitude hypoxia on ultrastructure of the left ventricle of rabbit heart and the response of the myocardium to acute verapamil administration at different altitudes].
It was shown in experiments on intact male rabbits that moderate-altitude hypoxia causes over-stress of the cardiomyocyte energy-producing apparatus in unadapted animals. Acute infusion of verapamil leads to a high mortality rate among these animals, whereas among aborigines of moderate and low altitudes as well as among animals living in the planes mortality in acute verapamil infusion does not exceed 30%.
Frolov
V A
VA
Matyev
E S
ES
Pukhlianko
V P
VP
Mambetsadykov
M B
MB
D000532:Altitude Sickness / Q000473:pathology*; D000818:Animals; D006321:Heart / Q000187:drug effects*; D006352:Heart Ventricles / Q000648:ultrastructure; D008297:Male; D011817:Rabbits; D014700:Verapamil / Q000627:therapeutic use*
D014700:Verapamil
Vliianie gornoĭ gipoksii na sostoianie ul'trastruktury levogo zheludochka serdtsa krolikov i reaktsiia miokarda na ostroe vvedenie verapamila na razlichnykh vysotakh.