Effect of bezafibrate & nicotinic acid on triton induced hyperlipidemias in CFY rats.
The two mechanisms of action of bezafibrate and nicotinic acid and their combination were evaluated in normal rats and triton treated rats. Bezafibrate was effective hypolipidemic agent in normal rats, but addition of nicotinic acid has certainly improved the effectiveness further which could be of clinical significance. In triton treated rats bezafibrate and nicotinic acid used individually and together had prophylactic hypolipidemic action. However, in their therapeutic effectiveness, bezafibrate reduced triglycerides (65.4%) and nicotinic acid, cholesterol (39.3%). But when treated together they showed marked acceleration in the removal of cholesterol as well as triglycerides. It is therefore concluded that a combination of bezafibrate and nicotinic acid may be beneficial in the treatment of hyperlipoproteinemias, both prophylactically and therapeutically.
Krishnamurthy
A
A
Biology Division, IDPL Research Centre, Indian Drugs & Pharmaceuticals Ltd., Hyderabad.
Thapar
G S
GS
D000818:Animals; D001629:Bezafibrate / Q000008:administration & dosage / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D004359:Drug Therapy, Combination; D006949:Hyperlipidemias / Q000188:drug therapy*; D008297:Male; D009525:Niacin / Q000008:administration & dosage / Q000627:therapeutic use*; D011092:Polyethylene Glycols; D051381:Rats; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D009525:Niacin; D011092:Polyethylene Glycols; D002784:Cholesterol; D001629:Bezafibrate