Blood platelet serotonin following enterectomy in rats.
The role of the intestine as a source of platelet serotonin was investigated. Radioactive serotonin precursor. 5-Hydroxytryptophan was injected into enterectomised and sham-operated rats. Blood samples were taken at time intervals and serotonin uptake was estimated by radioactive counting. Soon (1-2 hrs) after surgery and under sodium pentobarbital anaesthesia, platelet 5HT activity was higher in enterectomised rats than in controls. The intestine may not be the major source of platelet serotonin.
Osim
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EE
Surgical Unit, Faculty of Clinical Sciences, University College London, Rayne Institute.
Wyllie
J H
JH
D006916:5-Hydroxytryptophan / Q000008:administration & dosage; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D004759:Enterochromaffin Cells / Q000502:physiology; D007420:Intestine, Large / Q000502:physiology / Q000601:surgery; D007421:Intestine, Small / Q000502:physiology / Q000601:surgery; D007422:Intestines / Q000502:physiology* / Q000601:surgery; D010976:Platelet Count; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D006916:5-Hydroxytryptophan