Beta-lactamase induction antagonizes beta-lactam susceptibilities in Citrobacter diversus and Enterobacter cloacae clinical isolates.
Inducible beta-lactamases were obtained after exposure to several beta-lactams in clinical isolates of Enterobacter cloacae and Citrobacter diversus. Enzyme production was related to the inducer and medium composition. beta-lactamase is able to inactivate only labile compounds, thus generating minimum inhibitory concentrations higher than in the absence of the inducer; imipenem susceptibilities usually were not changed.
Oliva
B
B
Dept. of Experimental Medicine and Sciences, University of L'Aquila, Italy.
Taraborelli
T
T
Franceschini
N
N
Amicosante
G
G
D002954:Citrobacter / Q000187:drug effects / Q000201:enzymology*; D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology*; D004790:Enzyme Induction; D008826:Microbial Sensitivity Tests; D008997:Monobactams / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001618:beta-Lactamases / Q000096:biosynthesis*
D008997:Monobactams; D001618:beta-Lactamases