title: Influence of anticoagulants on growth and vitamin K production of intestinal bacteria.
abstract: The influence of anticoagulants on growth and vitamin K production of intestinal bacteria was studied. Bacteroides vulgatus and Escherichia coli were grown in vitro in the presence of increasing amounts of warfarin, phenprocoumon and acenocoumarol. It was found that growth of B. vulgatus was inhibited under anaerobic conditions whereas growth of E. coli under aerobic conditions was not inhibited. A specific inhibition of vitamin K biosynthesis was not observed in either case. It is concluded that therapeutic doses of anticoagulants are unlikely to affect growth or vitamin K production of intestinal bacteria.
authors.affiliation: Institut für Pharmazeutische Biologie, Rheinischen Friedrich-Wilhelms-Universität Bonn.
authors.forename: M
authors.initials: M
authors.lastname: Johanni
authors.forename: J
authors.initials: J
authors.lastname: Ungerechts
authors.forename: H
authors.initials: H
authors.lastname: Werner
authors.forename: E
authors.initials: E
authors.lastname: Leistner
mesh_terms: D000074:Acenocoumarol / Q000494:pharmacology; D000332:Aerobiosis; D000693:Anaerobiosis; D000925:Anticoagulants / Q000494:pharmacology*; D001439:Bacteroides / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010644:Phenprocoumon / Q000494:pharmacology; D014812:Vitamin K / Q000096:biosynthesis*; D014859:Warfarin / Q000494:pharmacology
chemical_list: D000925:Anticoagulants; D014812:Vitamin K; D014859:Warfarin; D000074:Acenocoumarol; D010644:Phenprocoumon