[Pyruvic acid in the rat liver and myocardium after acute chlorfenvinphos poisoning].
The authors studied the effect of chlorfenvinphos on the pyruvic acid level in the liver and cardiac muscle of male Wistar rats. The animals were intoxicated with chlorfenvinphos in a single oral dose of 5 mg/kg (0.5 LD50). The pyruvate was assayed spectrophotometrically after 2, 4 and 24 hours following administration of the insecticide. The results obtained indicate that after intoxication with chlorfenvinphos there are no changes in the pyruvic acid level in the liver, but in the heart muscle, two hours after administration of insecticide, a significant decrease of this keto acid was observed. No alterations were found 4 and 24 hours after intoxication with chlorfenvinphos.
Szczepaniak
S
S
Katedry i Zakładu Chemii Toksykologicznej Akademii Medycznej w Lublinie.
Nowiński
H
H
Jeleniewicz
K
K
Maciejewska-Kozak
H
H
D000208:Acute Disease; D000818:Animals; D002709:Chlorfenvinphos / Q000506:poisoning*; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011773:Pyruvates / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011773:Pyruvates; D019289:Pyruvic Acid; D002709:Chlorfenvinphos
Kwas pirogronowy w watrobie i sercu szczura w warunkach ostrej intoksykacji chlorfenwinfosem.