title: Synthesis of optically active lipopeptide analogs from the outer membrane of Escherichia coli.
abstract: The synthesis of optically active lipopeptide derivatives has been accomplished by the use of chiral glycerol derivatives. Lipopeptide derivatives with (R)-glycerol moieties showed higher mitogenic activities than those with the (S)-configuration. N-2,2,2-Trichloroethoxycarbonyl lipopeptide derivatives increased mitogenic activity.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kurimura
authors.forename: M
authors.initials: M
authors.lastname: Takemoto
authors.forename: K
authors.initials: K
authors.lastname: Achiwa
mesh_terms: D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000138:chemical synthesis* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D004926:Escherichia coli / Q000378:metabolism*; D008074:Lipoproteins / Q000138:chemical synthesis* / Q000494:pharmacology; D008934:Mitogens / Q000138:chemical synthesis / Q000494:pharmacology; D008969:Molecular Sequence Data; D013237:Stereoisomerism
chemical_list: D001425:Bacterial Outer Membrane Proteins; D008074:Lipoproteins; D008934:Mitogens