The release of naproxen in fatty suppository bases by beta-cyclodextrin complexation.
The effect of beta-cyclodextrin (beta-CD) on the release of naproxen (1) from fatty suppository bases was investigated. The solid complexes of 1 with beta-CD in a molar ratio of 1:1 were prepared by using the kneading, co-precipitation and grinding method. Witepsol H15 and Massa Estarinum B suppositories were prepared, containing the intact 1 and 1-beta-CD complex, respectively. The in vitro release of 1 from fatty bases was examined. The release data were assessed kinetically. The best fit was obtained with Q vs. the square root of time.
Celebi
N
N
Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
Iscanoglu
M
M
Degim
T
T
D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins; D008055:Lipids; D009288:Naproxen / Q000008:administration & dosage / Q000737:chemistry*; D013488:Suppositories; D014280:Triglycerides; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D008055:Lipids; D013488:Suppositories; D014280:Triglycerides; D047392:beta-Cyclodextrins; C009683:witepsol; D009288:Naproxen; C031215:betadex