[The specificity of the genotoxic action of carcinogenic aromatic compounds on Drosophila mus mutants].
Hypersensitivity to the toxic effect of benzo(a)pyrene (B(a)P) was determined in homozygous larvae of two D. melanogaster mus strains (mus 208B2 and mus210). The two others (mus205B1 and mus208B1) were found to be less sensitive and the parent strain was resistant. The lack of correlation between the sensitivity in larvae and the activity of aryl hydrocarbon hydroxylase in S15 fractions from adult flies whole body homogenates of the same strains was demonstrated. The hypertoxic effect of B(a)P and 2-acethylaminofluorene in strain mus210 seems to be rather specific because noncarcinogenic pyrene, benzo(e)pyrene and fluorene did not affect the survival of this most sensitive strain. Perspectives of the strain mus210 use for the environmental genotoxic pollutants screening were discussed.
Shpigel'man
V S
VS
Fuks
S Iu
SIu
Safaev
R D
RD
Belitskiĭ
G A
GA
D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity*; D004331:Drosophila melanogaster; D005796:Genes / Q000187:drug effects*; D006579:Heterozygote; D006720:Homozygote; D009154:Mutation / Q000187:drug effects*; D011083:Polycyclic Compounds / Q000633:toxicity*
D002273:Carcinogens; D011083:Polycyclic Compounds
Spetsifichnost' genotoksicheskogo deĭstviia kantserogennykh aromaticheskikh soedineniĭ na mus-mutanty drozofily.