title: Necessary conditions for the method of inferring phylogeny by linear invariants.
abstract: It is known that if all the Markov transition matrices that govern the substitution of one nucleotide for another satisfy six linear constraints, then equations can be derived that permit one to infer evolutionary trees from nucleic acid sequences by the method of linear invariants. These sufficient conditions are also necessary. Any relaxation of them results in the loss of all linear invariants. Necessary conditions for any given set of linear invariants can be derived by examining conditions a matrix must satisfy to map a certain set of matrices into itself. To the extent that necessary conditions are incorrect, a method is not reliable. In a world where different parts of molecules evolve at different rates, the two-parameter model of Kimura may not be empirically distinguishable from the more general one treated here.
authors.affiliation: Department of Mathematics, University of Colorado, Denver 80204.
authors.forename: J A
authors.initials: JA
authors.lastname: Cavender
mesh_terms: D001483:Base Sequence; D008433:Mathematics; D015233:Models, Statistical; D009696:Nucleic Acids; D010802:Phylogeny; D011336:Probability
chemical_list: D009696:Nucleic Acids