title: [Systemic connective tissue diseases--prognostic conclusions of a 30-year study].
abstract: In the course of the last three decades a gradually supplemented group of 627 patients was subjected to prognostic analysis, incl. 388 with systemic lupus erythematosus, 160 with diffuse scleroderma, 51 with dermato- and polymyositis and 28 with a mixed connective tissue syndrome. Taking into account the onset of the disease, sex, extent of organ affection and therapy as well as the survival period and mortality, the conclusions of the statistical evaluation revealed that more than 90% of patients survived for more than 5 years: 92.2% with systemic lupus erythematosus, 94.3% with diffuse scleroderma 93.3% with dermato- and polymyositis and 100% with mixed connective tissue syndrome; a ten-year survival was recorded in cca 80% patients (77.6% with systemic lupus erythematosus, 81.1% with diffuse scleroderma, 89.7% with dermato- and polymyositis); a 15-year survival was recorded still by more than 50% patients (53.4% with systemic lupus erythematosus, 58.2% with diffuse scleroderma and as many as 80.0% with dermato- and polymyositis). The above data indicate considerable improvement of the prospects of these diseases, whereby the more than treble prolongation of survival of patients as compared with the previous period is due to effective, although not causal immunotherapy, in particular in systemic lupus erythematosus and dermato- and polymyositis.
authors.affiliation: Výskumný ústav reumatických chorôb, Piestany.
authors.forename: D
authors.initials: D
authors.lastname: Zitnan
authors.forename: J
authors.initials: J
authors.lastname: Rovenský
authors.forename: J
authors.initials: J
authors.lastname: Lukác
authors.forename: M
authors.initials: M
authors.lastname: Zatkalík
authors.forename: H
authors.initials: H
authors.lastname: Tauchmannová
mesh_terms: D000328:Adult; D000368:Aged; D003240:Connective Tissue Diseases / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011379:Prognosis
vernacular_title: Systémové choroby spojiva--prognostické závery 30-ronej stúdie.