title: Glia maturation factor beta stimulates axon regeneration in transected rat sciatic nerve.
abstract: Rat sciatic nerves were bilaterally transected and repaired with an entubulation technique. The nerve interstump gap was filled with either collagen gel or collagen gel mixed with a putative neurotrophic factor (leupeptin, 4-aminopyridine, lipid angiogenic factor or glia maturation factor beta (GMF-beta]. Six weeks after nerve transection, the myelinated distal stump axons were quantified for each nerve. Only the nerves treated with GMF-beta had significantly more axons than the control side.
authors.affiliation: Physiotherapy Program, University of Ottawa, Ont. Canada.
authors.forename: K
authors.initials: K
authors.lastname: Harman
authors.forename: J
authors.initials: J
authors.lastname: Katnick
authors.forename: R
authors.initials: R
authors.lastname: Lim
authors.forename: A
authors.initials: A
authors.lastname: Zaheer
authors.forename: J C
authors.initials: JC
authors.lastname: de la Torre
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology; D005260:Female; D020904:Glia Maturation Factor; D009414:Nerve Growth Factors; D009416:Nerve Regeneration / Q000187:drug effects*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D012584:Sciatic Nerve / Q000166:cytology* / Q000187:drug effects
chemical_list: D020904:Glia Maturation Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins; D003094:Collagen