title: Toxicity studies in mice of ethanol extracts of Foeniculum vulgare fruit and Ruta chalepensis aerial parts.
abstract: Acute (24-h) and chronic (90-day) oral toxicity studies on the ethanolic extracts of Foeniculum vulgare fruit and Ruta chalepensis aerial parts were carried out in mice. Acute dosages were 0.5, 1.0 and 3 g/kg while the chronic dosage was 100 mg/kg per day of extract. All external morphological, haematological and spermatogenic changes, in addition to body and vital organ weights were recorded. The extracts caused no significant acute or chronic mortality as compared to controls during this investigation. The treated male mice gained significant weight during chronic treatment while a loss or no significant change in weight was noticed in the female mice treated with the same extracts. Haematological studies revealed a significant fall in RBC level of R. chalepensis-treated animals. Both the extracts failed to show spermatotoxic effects.
authors.affiliation: Central Laboratory for Drug and Food Analysis, Riyadh, Saudi Arabia.
authors.forename: A H
authors.initials: AH
authors.lastname: Shah
authors.forename: S
authors.initials: S
authors.lastname: Qureshi
authors.forename: A M
authors.initials: AM
authors.lastname: Ageel
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D000431:Ethanol / Q000737:chemistry; D005260:Female; D005638:Fruit; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010936:Plant Extracts / Q000009:adverse effects*; D010946:Plants, Medicinal
chemical_list: D010936:Plant Extracts; D000431:Ethanol