Wound healing profile of topical xylocaine preparations in rodents.
Local anesthetics are commonly used for alleviating pain in many clinical conditions associated with wound. Present study is undertaken to unravel the implications of two xylocaine preparations on dermal wound repair in albino rats. Application of xylocaine either as jelly or ointment significantly reduced skin wound breaking strength and promoted re-epithelization. While bases of xylocaine jelly and ointment had no action on skin wound breaking strength but enhanced re-epithelization. Current findings, suggest that prior knowledge of the effects of substances incorporated in topical preparations on wound repair is important for their judicious use and selection of preparation in relevant clinical conditions.
Madhuchandra
S P
SP
Department of Pharmacology, Kasturba Medical College, Mangalore, India.
Bhat
M P
MP
Ramesh
K V
KV
D000287:Administration, Topical; D000818:Animals; D005260:Female; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing / Q000187:drug effects*
D008012:Lidocaine