[A standardized in vivo model for determining the effectiveness of surfactant preparations].
The premature rabbit neonate of the 27th day of gestation is a useful model for testing intratracheally applied surfactant preparations. Immediately after application of an effective surfactant the thorax lung compliance--as the decisive measure--rises significantly. We could exclude effects of the applied fluid per se. The most reliable result about the efficiency of a surfactant preparation is given by the cumulative dose response relationship. In a semilogarithmic system there is a linear relationship between the surfactant dose (25-200 mg phospholipids per kg b.w.) and the thorax-lung-compliance.
Oddoy
A
A
Forschungsinstitut für Lungenkrankheiten und Tuberkulose Berlin-Buch.
D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007231:Infant, Newborn; D008170:Lung Compliance / Q000187:drug effects* / Q000502:physiology; D011663:Pulmonary Surfactants / Q000008:administration & dosage* / Q000502:physiology; D011817:Rabbits; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology / Q000628:therapy*
D011663:Pulmonary Surfactants
Ein standardisiertes In-vivo-Modell zur Wirksamkeitsbestimmung von Surfactant-Präparaten.