Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration.
Twelve children 1-5 y old were randomly assigned to receive midazolam 0.2 mg.kg-1 either by the intravenous (IV) or intranasal (IN) routes. After IN administration the rapid onset of absorption was observed (tmax 12 min). After both routes of administration the half-life was similar (2.2 h IN and 2.4 h IV). After IN administration the apparent plasma clearance and volume of distribution were about twice as high as after IV administration. The results are consistent with an estimated mean bioavailability of 55%.
Rey
E
E
Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France.
Delaunay
L
L
Pons
G
G
Murat
I
I
Richard
M O
MO
Saint-Maurice
C
C
Olive
G
G
D000281:Administration, Intranasal; D001682:Biological Availability; D002675:Child, Preschool; D006207:Half-Life; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008874:Midazolam / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D008874:Midazolam