[The effect of smoking on immunological parameters in silicosis].
The paper reports on the smoking influence on some immunologic parameters in a group of patients with micronodular silicosis. 3 groups of subjects were studied: I--group with micronodular silicosis, smokers with cigarette index 300; II--group with micronodular silicosis, nonsmokers; III--control group. The following immunologic parameters were determined: 1. Test of blastic transformation of LT at PHA and PHA+IL-1 TTB; 2. Inhibition of leukocyte migration--indirect test; 3. Phagocytosis test of sheep erythrocytes. The results obtained show, in the patients with silicosis, suppression of the ability of blastic transformation, of lymphokines release and non-efficient phagocytosis. Improvement of the lymphocyte function by adding IL-1 suggests a deficiency of this monokine in inducing modified immune response in these patients. Smoking depresses more obviously cellular mediated immune response, induced by silicosis.
Surcel
D
D
Institutul de Igienă şi Sănătate Publică, Cluj.
Ossian
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A
Nagy
L
L
Cocîrlă
A
A
Milea
M
M
D002464:Cell Migration Inhibition; D002908:Chronic Disease; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008875:Middle Aged; D010587:Phagocytosis / Q000276:immunology; D010835:Phytohemagglutinins; D012829:Silicosis / Q000276:immunology*; D012907:Smoking / Q000009:adverse effects / Q000276:immunology*
D007375:Interleukin-1; D010835:Phytohemagglutinins
Influenţa fumatului asupra unor parametri imunologici în silicoză.