[Cerebral MRT in x chromosome linked adrenoleukodystrophy].
Adrenoleukodystrophy (ALD) is a rare lipid storage disease, characterized among other symptoms by a progressive demyelinization of white matter. Changes are well demonstrated by MRT: Leukencephalopathy begins symmetrically in the occipital lobes of the cerebrum and involves furthermore the splenium of the corpus callosum, the nucleus dentatus and the descending tracts. As neurologic signs may precede signs of adrenal insufficiency, MRT may be important to suspect the diagnosis of ALD, which generally is diagnosed by biochemical tests.
Kujat
C
C
Funktionsbereich Kernspintomographie, Universitätskliniken des Saarlandes, Homburg/Saar.
Halb
A
A
Hermes
M
M
Scherb
T
T
Hadidi
H
H
Henkes
H
H
Dewes
W
W
D000326:Adrenoleukodystrophy / Q000175:diagnosis* / Q000235:genetics*; D001921:Brain / Q000473:pathology*; D002648:Child; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D012729:Sex Chromosome Aberrations / Q000175:diagnosis* / Q000235:genetics*; D014960:X Chromosome
Zerebrale MRT bei X-chromosomal gebundener Adrenoleukodystrophie.