title: Interaction of mutant forms of the HIV-1 protease with substrate and inhibitors.
authors.affiliation: Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486.
authors.forename: P L
authors.initials: PL
authors.lastname: Darke
authors.forename: N E
authors.initials: NE
authors.lastname: Kohl
authors.forename: M G
authors.initials: MG
authors.lastname: Hanobik
authors.forename: C T
authors.initials: CT
authors.lastname: Leu
authors.forename: J P
authors.initials: JP
authors.lastname: Vacca
authors.forename: J P
authors.initials: JP
authors.lastname: Guare
authors.forename: J C
authors.initials: JC
authors.lastname: Heimbach
authors.forename: R A
authors.initials: RA
authors.lastname: Dixon
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D004926:Escherichia coli / Q000235:genetics; D016333:HIV Protease / Q000235:genetics* / Q000378:metabolism; D017320:HIV Protease Inhibitors; D007700:Kinetics; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D009842:Oligopeptides / Q000737:chemistry; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology; D013379:Substrate Specificity
chemical_list: D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D011480:Protease Inhibitors; D016333:HIV Protease