Effects of endothelin-1 on vascular tension in human umbilical vessels.
The effect of endothelin-1 on vascular tension has been investigated in human umbilical cord vessels perfused in vitro and compared to that of serotonin. Both autacoids induced vasoconstrictions in the arteries and in the veins, all responses being clearly dose-dependent. Endothelin-1 was found to be most potent, eliciting visible pressure changes in concentrations of 10(-11)-10(-10) M. The responses to 10(-9) M endothelin-1 in the veins increased markedly at repeated stimulations. In the arteries a potentiating effect on the serotonin response was observed after exposure to 10(-11) M of endothelin-1. The results signal that the peptide may be of significance in the regulation of umbilicoplacental blood flow.
Haugen
G
G
Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway.
Stray-Pedersen
S
S
D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D016232:Endothelins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D012701:Serotonin / Q000494:pharmacology; D014469:Umbilical Arteries / Q000187:drug effects*; D014471:Umbilical Veins / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects
D016232:Endothelins; D012701:Serotonin