Glia maturation factor beta stimulates axon regeneration in transected rat sciatic nerve.
Rat sciatic nerves were bilaterally transected and repaired with an entubulation technique. The nerve interstump gap was filled with either collagen gel or collagen gel mixed with a putative neurotrophic factor (leupeptin, 4-aminopyridine, lipid angiogenic factor or glia maturation factor beta (GMF-beta]. Six weeks after nerve transection, the myelinated distal stump axons were quantified for each nerve. Only the nerves treated with GMF-beta had significantly more axons than the control side.
Harman
K
K
Physiotherapy Program, University of Ottawa, Ont. Canada.
Katnick
J
J
Lim
R
R
Zaheer
A
A
de la Torre
J C
JC
D000818:Animals; D001369:Axons / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology; D005260:Female; D020904:Glia Maturation Factor; D009414:Nerve Growth Factors; D009416:Nerve Regeneration / Q000187:drug effects*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D012584:Sciatic Nerve / Q000166:cytology* / Q000187:drug effects
D020904:Glia Maturation Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins; D003094:Collagen