A negative inotropic effect of omega-conotoxin GVIA in isolated, blood-perfused dog right atria.
Using an isolated, blood-perfused canine atrial preparation, we investigated the effects of omega-conotoxin GVIA (omega-CgTX), a blocker of N-type voltage-operated calcium channels, on the atrial contractile force and sinus rate. Omega-CgTX in a dose range of 0.3-3 nmol gradually attenuated the atrial contractile force in a dose-dependent manner, but did not affect the sinus rate, indicating that it can depress contractility but not pacemaker activity.
Ren
L M
LM
Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Furukawa
Y
Y
Karasawa
Y
Y
Murakami
M
M
Takayama
S
S
Inoue
Y
Y
Sawaki
S
S
Chiba
S
S
D000818:Animals; D016280:Atrial Function, Right / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003864:Depression, Chemical; D004285:Dogs; D006325:Heart Atria / Q000187:drug effects*; D006339:Heart Rate; D009200:Myocardial Contraction / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D010477:Perfusion; D012849:Sinoatrial Node / Q000187:drug effects; D020866:omega-Conotoxin GVIA
D002121:Calcium Channel Blockers; D010456:Peptides, Cyclic; D020866:omega-Conotoxin GVIA