title: Biologically active constituents of Arnebia euchroma: structure of arnebinol, an ansa-type monoterpenylbenzenoid with inhibitory activity on prostaglandin biosynthesis.
abstract: Three phenolic compounds were isolated from the roots of Arnebia euchroma as inhibitors of in vitro prostaglandin biosynthesis. Two known compounds were identified as shikonofurans and des-O-methyllasiodiplodin. The other new compound was named arnebinol and its structure was elucidated as a novel ansa-type monoterpenylbenzenoid derivative.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
authors.forename: X S
authors.initials: XS
authors.lastname: Yao
authors.forename: Y
authors.initials: Y
authors.lastname: Ebizuka
authors.forename: H
authors.initials: H
authors.lastname: Noguchi
authors.forename: F
authors.initials: F
authors.lastname: Kiuchi
authors.forename: M
authors.initials: M
authors.lastname: Shibuya
authors.forename: Y
authors.initials: Y
authors.lastname: Iitaka
authors.forename: H
authors.initials: H
authors.lastname: Seto
authors.forename: U
authors.initials: U
authors.lastname: Sankawa
mesh_terms: D000818:Animals; D003864:Depression, Chemical; D066298:In Vitro Techniques; D007679:Kidney Medulla / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits; D013729:Terpenes / Q000032:analysis* / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D011453:Prostaglandins; D013729:Terpenes; C073509:arnebinol