[Correlation between serum glutathione reductases and bone densitometry values].
Free radicals, because of their marked chemical activity, have often been found to be involved in many human diseases. Enzymatic antioxidant systems, namely glutathione-reductase, present both in red blood cells and in serum, have been demonstrated to play a key role as free radicals scavengers. The present work has been carried out in order to evaluate the possible role played by free radicals in the demineralization process of the bone matrix. Glutathione-reductase activity, assayed by a slightly modified Horn's method, was related to bone density measurements. All the subjects with reduced densitometric values showed reduced glutathione-reductase levels. Our results seem to support the hypothesis of a strict relationship between low activity of antioxidant systems and demineralization process of the bone, in consequence of enhanced free radical levels.
Avitabile
M
M
Laboratorio Centralizzato Corso di Laurea in Odontoiatria, Università degli Studi di Catania.
Campagna
N E
NE
Magrì
G A
GA
Vinci
M
M
Sciacca
G
G
Alia
G
G
Ferro
A
A
D000368:Aged; D015519:Bone Density; D001862:Bone Resorption / Q000201:enzymology; D005260:Female; D016166:Free Radical Scavengers; D005980:Glutathione Reductase / Q000097:blood* / Q000172:deficiency; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000201:enzymology
D016166:Free Radical Scavengers; D005980:Glutathione Reductase
Correlazione tra glutatione-reduttasi serica e valori densitometrici ossei.