title: Chloral hydrate toxicity in a term infant.
abstract: Chlorate hydrate is commonly used for neonatal sedation, but blood levels are infrequently monitored, reflecting an underemphasis of acute toxic effects. This report describes a case of chloral hydrate toxicity in a term infant with cardiac, renal, neurologic, bladder and gastrointestinal dysfunction. The effects of exchange transfusion are described as well as pharmacokinetics.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas.
authors.forename: M A
authors.initials: MA
authors.lastname: Anyebuno
authors.forename: C R
authors.initials: CR
authors.lastname: Rosenfeld
mesh_terms: D000284:Administration, Oral; D002697:Chloral Hydrate / Q000506:poisoning*; D004562:Electrocardiography; D005023:Ethylene Chlorohydrin / Q000031:analogs & derivatives / Q000097:blood; D005078:Exchange Transfusion, Whole Blood; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male
chemical_list: D002697:Chloral Hydrate; D005023:Ethylene Chlorohydrin; C005849:2,2,2-trichloroethanol