The iron chelator deferoxamine prevents cisplatin-induced lipid peroxidation in rat kidney cortical slices.
We evaluated the effect of the iron chelator deferoxamine on lipid peroxidation produced by the nephrotoxic antineoplastic drug cisplatin in rat kidney cortical slices. The addition of deferoxamine to the incubation medium prevented such lipid peroxidation in the incubated slices. Treatment of rats with deferoxamine inhibited the increase in lipid peroxidation caused by cisplatin in the medium. These results suggest that iron may be a causal agent of cisplatin-induced lipid peroxidation.
Kameyama
Y
Y
Division of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan.
Gemba
M
M
D000818:Animals; D002945:Cisplatin / Q000009:adverse effects*; D003676:Deferoxamine / Q000378:metabolism / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000494:pharmacology*; D007672:Kidney Cortex / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D007502:Iron Chelating Agents; D008315:Malondialdehyde; D007501:Iron; D005978:Glutathione; D003676:Deferoxamine; D002945:Cisplatin