Intradermal antityphoid-antitetanus vaccination by jet injection.
A lyophilized, heat-killed, phenol preserved typhoid vaccine (5 x 10(8) cells) suspended in 0.1 ml unadsorbed concentrated tetanus vaccine (10 Lf) was administered in man by intradermal route. This association of the two vaccines resulted in milder postvaccinal reactions: moreover, the immunological properties of typhoid vaccine, as certified by the passive protection test of the mouse with sera of the vaccines and the H and O agglutinin titres found in these immune sera, were perfectly conserved. Consequently, the mixed typhoid-tetanus vaccination in man by intradermal route is possible and advantageous for practical and economical reasons.
Dimache
G
G
Contacuzino Institute, Bucharest, Romania.
Croitoru
M
M
Velea
V
V
Stoean
C
C
Durbacă
S
S
Mihăilescu
M
M
Dimache
A
A
D000293:Adolescent; D000328:Adult; D000373:Agglutinins / Q000097:blood; D000818:Animals; D005260:Female; D006801:Humans; D007114:Immunization; D007271:Injections, Intradermal; D007277:Injections, Jet; D008297:Male; D051379:Mice; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D013997:Time Factors; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology
D000373:Agglutinins; D013745:Tetanus Toxoid; D014436:Typhoid-Paratyphoid Vaccines