[Effect of phosphatidylcholine liposomes on lipid peroxidation in the liver and phospholipid metabolism in hepatocyte plasma membrane in hemorrhagic shock].
The possibility of protecting the liver from lipid peroxidation (LPO) by phosphatidylcholine liposomes was studied in a model of hemorrhagic shock. Augmentation of LPO in hemorrhagic shock correlated with a decrease in phosphatidylcholine levels in the plasma membranes of hepatocytes and an increase in phosphatidylinositol content. With the use of liposomes the activation of LPO in the liver was removed and the level of phosphatidylcholine and phosphatidylinositol in the hepatocyte plasma membrane was restored.
Leskova
G F
GF
Udovichenko
V I
VI
D000818:Animals; D002415:Cats; D002462:Cell Membrane / Q000502:physiology; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000378:metabolism
D008081:Liposomes; D010713:Phosphatidylcholines; D010743:Phospholipids
Vliianie fosfatidilkholinovykh liposom na perekisnoe okislenie lipidov v pecheni i obmen fosfolipidov plazmaticheskikh membran gepatotsitov pri gemorragicheskom shoke.