title: Influences of cigarette smoke inhalation on pharmacokinetics of cimetidine in rats.
abstract: The influences of cigarette smoke inhalation on the pharmacokinetics of cimetidine administered orally and parenterally were investigated in rats using a smoking machine. The animals were exposed to two kinds of cigarette smoke, low- or high-nicotine.tar, inhaled for 10 min immediately after oral (50 mg/kg), intraperitoneal (25 mg/kg) or intravenous (10 mg/kg) administration of cimetidine. The plasma level after cimetidine was administered orally was lower in the absorption phase in the two cigarette smoke inhaling groups than in the non-smoking control group, and was particularly marked in the high-nicotine.tar cigarette smoke inhaling group. In contrast, no significant difference was found in cimetidine plasma level between the cigarette smoke inhaling groups and the non-smoking control group when administered intraperitoneally or intravenously. These results suggest that cigarette smoke inhalation may cause a suppression or a delay in cimetidine absorption from the gastrointestinal tract, and that the degree of influence is dependent upon the content of nicotine.tar in the cigarette smoke.
authors.affiliation: Department of Hospital Pharmacy, Okayama University Dental School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Eto
authors.forename: Y
authors.initials: Y
authors.lastname: Gomita
authors.forename: K
authors.initials: K
authors.lastname: Furuno
authors.forename: K
authors.initials: K
authors.lastname: Yao
authors.forename: M
authors.initials: M
authors.lastname: Moriyama
authors.forename: Y
authors.initials: Y
authors.lastname: Araki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002927:Cimetidine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D010947:Plants, Toxic; D051381:Rats; D011919:Rats, Inbred Strains; D012906:Smoke; D014026:Nicotiana
chemical_list: D012906:Smoke; D002927:Cimetidine