[Blood system responses in inflammation and mechanisms of their development].
A model of acute infectious peritonitis in mice demonstrated that the inflammation is attended by marked biphasic activation of bone-marrow granulomonocytopoiesis and that the activation is due in many respects to increased functional activity of elements forming the hemopoiesis-inducing microenvironment. This was suggested by increased colony-stimulating activity of the marrow mononuclear cells and the content of hemopoietic islets in the marrow. The colony-stimulating activity of peripheral blood also increased. It was established that inflammation is also characterized by activation of bone-marrow erythropoiesis, which is linked with increased erythropoietic activity of the hemopoiesis-inducing microenvironment and blood. There was a relation between the hemopoietic changes and the kinetics of leukocytes in the focus of inflammation.
Dygaĭ
A M
AM
Klimenko
N A
NA
Abramova
E V
EV
Khakhov
V P
VP
Bogdashin
I V
IV
Zakharova
O Iu
OIu
Simanina
E V
EV
Sherstoboev
E Iu
EIu
Gumilevskiĭ
B Iu
BIu
Boldyshev
D A
DA
D000818:Animals; D006410:Hematopoiesis / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010538:Peritonitis / Q000097:blood / Q000276:immunology*
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