Circadian patterns of myocardial ischaemia and the effects of antianginal drugs.
Chronopathology of cardiovascular disease is now well documented. Silent myocardial ischaemia involves the same pathophysiological changes as conventional ischaemia. Early morning peaks in angina and myocardial ischaemia call for adequate timing of medication. beta-blockers abolish the morning peak, and aspirin reduces morning infarctions. The effects of other antianginals on these phenomena are presently unknown.
Purcell
H
H
Department of Cardiology, Royal Brompton National Heart and Lung Hospital, London, U.K.
Mulcahy
D
D
Fox
K
K
D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000494:pharmacology; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D004334:Drug Administration Schedule; D006339:Heart Rate / Q000502:physiology; D006801:Humans
D002317:Cardiovascular Agents