title: [Prolonged cardioselective blockade of beta-1 adrenoreceptors in combination with increased diuresis as a method of choice in the treatment of hypertension].
abstract: The clinical effects of Tenoric, a long-acting combined drug (atenolol and chlorthalidone in a tablet), were studied in 31 patients with Stages I and II hypertensive disease, by using echocardiography, daily automatic blood pressure monitoring, bicycle ergometry, measurements of plasma renin and aldosterone. The drug was found to be highly clinically effective in labile and sustained hypertension. When given once or twice a day, it makes it possible to reliably monitor blood pressure, improve hemodynamic parameters, as reflected by lower cardiac output and decreased peripheral vascular resistance, reduce the estimated mass of the left myocardium, alleviate a pressor response to exercise and enhance its tolerance, lower plasma renin levels. The side effects of the drug are minimal and include moderate bradycardia. Peripheral vasospasm and systemic weakness were observed in single cases. There were no atherogenic changes in lipid spectrum and disturbed glucose and uric acid metabolism during the drug therapy.
authors.forename: V T
authors.initials: VT
authors.lastname: Ivashkin
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Grigor'ev
authors.forename: A I
authors.initials: AI
authors.lastname: Sinopal'nikov
authors.forename: N V
authors.initials: NV
authors.lastname: Korneev
authors.forename: D N
authors.initials: DN
authors.lastname: Levitskiĭ
authors.lastname: KazakovaIG
authors.forename: E A
authors.initials: EA
authors.lastname: Virs
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use*; D002752:Chlorthalidone / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; C035884:atenolol, chlortalidone drug combinations; D001262:Atenolol; D002752:Chlorthalidone
vernacular_title: Prolongirovannaia kardioselektivnaia blokada beta-1-adrenoretseptorov v kombinatsii s usilennym diurezom kak metod vybora v lechenii gipertonicheskoĭ bolezni.