title: [Synthesis of heterocyclic immunomodulators. 1. Alkyl derivatives of 1,2,4-dithiazolidin-3,5-diyliden-bis(o-benzoquinone-meth ide): synthesis and testing of immunomodulating action].
abstract: Reactions of 1,2,4-dithiazolidine-3,5-diylidene-bis(o-benzoquinone-met hid) 3 with alkyl and substituted benzyl or phenacyl halides yield 1,2,4-dithiazol-3-ylidene-quinone-methides 4a-4i. Mass spectral fragmentations of 4a, 4c, and 4f are discussed. Tests for immunomodulating properties of 4a-c, 4e, and 4g are described. Some of these compounds show immuno-stimulatory activity.
authors.affiliation: Bereich Chemie biologisch aktiver Verbindungen, Universität Leipzig.
authors.forename: D
authors.initials: D
authors.lastname: Briel
authors.forename: S
authors.initials: S
authors.lastname: Leistner
authors.forename: K
authors.initials: K
authors.lastname: Drössler
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D012882:Skin Tests; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D016227:Benzoquinones; D013844:Thiazoles
vernacular_title: Synthese heterocyclischer Immunomodulatoren, 1. Mitt.: Alkylderivate von Prüfung auf immunomodulierende Wirkung.