Improved posthypoxic recovery with a membrane-permeable calpain inhibitor.
In vitro hippocampal slices from adult rats were subjected to transient hypoxia in the presence of a cell-penetrating, calpain inhibitor (Cbz-Val-Phe-H; MDL-28170). The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. These findings support a role for calcium-activated proteolysis in the process of hypoxic pathophysiology.
Arlinghaus
L
L
Department of Neurological Surgery, University of Virginia, Charlottesville 22908.
Mehdi
S
S
Lee
K S
KS
D000818:Animals; D002154:Calpain / Q000037:antagonists & inhibitors*; D016923:Cell Death / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology*; D006624:Hippocampus / Q000033:anatomy & histology / Q000187:drug effects / Q000201:enzymology; D000860:Hypoxia / Q000188:drug therapy* / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D004151:Dipeptides; D002154:Calpain; C058076:calpain inhibitor III