Uremic bone disease: current knowledge, controversial issues, and new horizons.
Abnormalities in mineral and bone metabolism occur early in the course of renal failure and uremic bone disease is a major contributing factor to the morbidity of patients with end-stage renal failure. In addition, new therapeutic approaches have generated new outlooks, problems and controversies. This article reviews our current accepted knowledge, the present numerous controversies, unresolved questions, new issues and new horizons.
Malluche
H H
HH
University of Kentucky, Division of Nephrology, Bone and Mineral Metabolism, Lexington.
Monier-Faugere
M C
MC
D000535:Aluminum / Q000009:adverse effects; D001842:Bone and Bones / Q000473:pathology; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control / Q000628:therapy; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D014511:Uremia / Q000150:complications*; D014807:Vitamin D / Q000378:metabolism / Q000627:therapeutic use
D004164:Diphosphonates; D014807:Vitamin D; D000535:Aluminum