title: [The experimental effect of the copolymer of 1-vinyl-3-methyl imidazole iodide with maleic acid diethyl ester on blood coagulability].
abstract: The antiheparin activity and acute toxicity of the copolymer of 1-vinyl-3-methyl inidazol iodide (VMII) with diethyl ether of maleic acid (DEMA) were investigated. It was shown that the injection of DEMA group to the molecule of VMII polymer was adequate for storage of a high antiheparin activity of the polymer with the structure. This composition of the copolymer has a low acute toxicity and high selectivity to heparin in the blood. Thrombocytopenia effect is absent.
authors.forename: G V
authors.initials: GV
authors.lastname: Afanas'eva
authors.forename: A A
authors.initials: AA
authors.lastname: Antonovich
authors.forename: V S
authors.initials: VS
authors.lastname: Efimov
authors.forename: A I
authors.initials: AI
authors.lastname: Smirnov
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D006494:Heparin Antagonists / Q000494:pharmacology* / Q000633:toxicity; D007093:Imidazoles / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D008298:Maleates / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D013997:Time Factors
chemical_list: D006494:Heparin Antagonists; D007093:Imidazoles; D008298:Maleates; C073477:1-vinyl-3-methylimidazole-maleic acid diethyl ester copolymer; C014476:diethyl maleate
vernacular_title: Vliianie sopolimera 1-vinil-3-metil imidazoliĭ ĭodida s diétilovym éfirom maleinovoĭ kisloty na svertyvaemost' krovi v éksperimente.