title: The cell mediated and humoral immune response to vaccination with acellular and whole cell pertussis vaccine in adult humans.
abstract: The cell mediated immune response (CMI) against pertussis antigens following vaccination with the traditional Danish whole cell pertussis vaccine (WC-P) and the Japanese acellular pertussis vaccine (A-PV) JNIH-3 was studied in four adult human volunteers. Vaccination with the A-PV induced an in vitro proliferative response of peripheral blood lymphocytes to pertussis toxin (PT) subunits S2-S4, S3-S4 and S5 and the filamentous hemagglutinin (FHA), and a better serological response to native PT, detoxified PT (dPT) and FHA than the WC-PV. The induced CMI and serological response were followed over a period of 17 weeks, and were not seen to decline during this period. Further, an in vitro proliferative response to Bordetella pertussis agglutinogen 2 and 3 were demonstrated using lymphocytes from recently and not-so-recently pertussis-vaccinated adults.
authors.affiliation: Bacterial Vaccine Department, Statens Seruminstitut, Copenhagen, Denmark.
authors.forename: J W
authors.initials: JW
authors.lastname: Petersen
authors.forename: P H
authors.initials: PH
authors.lastname: Ibsen
authors.forename: M W
authors.initials: MW
authors.lastname: Bentzon
authors.forename: C
authors.initials: C
authors.lastname: Capiau
authors.forename: I
authors.initials: I
authors.lastname: Heron
mesh_terms: D018829:Adhesins, Bacterial; D000328:Adult; D000917:Antibody Formation; D002455:Cell Division / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D006388:Hemagglutinins / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D010567:Pertussis Vaccine / Q000276:immunology*; D014611:Vaccination; D010566:Virulence Factors, Bordetella
chemical_list: D018829:Adhesins, Bacterial; D006388:Hemagglutinins; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella; C065273:filamentous hemagglutinin adhesin, Bordetella pertussis