Antifungal activity of fumaric acid in mice infected with Candida albicans.
An examination was made on the effect of fumaric acid on an experimental systemic candidiasis. Male ICR mice were innoculated into the tail veins with 10(6) yeast cells of Candida albicans and treated with daily intraperitoneal injections of fumaric acid at the dose of 40 mg/kg/d. The results indicated that the administration of fumaric acid was effective in prolonging the survival of animals after the fungal challenge and prevented one-fifth of the treated animals from dying of candidiasis.
Akao
M
M
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Kuroda
K
K
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D005650:Fumarates / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
D000935:Antifungal Agents; D005650:Fumarates; C032005:fumaric acid