Many membrane abnormalities in hypertension result from one primary defect.
Evidence has been presented that: 1.) Changes in lipid bilayer alter the function of integral membrane proteins. 2.) There is less calcium bound to the plasma membrane in hypertension. 3.) Structural and functional abnormalities of the lipid bilayer have been reported in genetic hypertension. We hypothesize that multiple abnormalities of membrane transport systems in hypertension are secondary to an inherent abnormality of the lipid bilayer in which these transport proteins reside.
Bohr
D F
DF
Department of Physiology, University of Michigan, School of Medicine, Ann Arbor 48109.
Furspan
P B
PB
Dominiczak
A F
AF
D000818:Animals; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D008055:Lipids / Q000502:physiology; D008566:Membranes / Q000378:metabolism / Q000502:physiology
D008055:Lipids