[Ileal absorption of various amino acids and dipeptides in rats administered cyclophosphamide--using the short-circuit current method].
Transport of amino acids; glycine, L-alanine, L-leucine, L-proline, L-lysine and dipeptides; gly-gly, gly-L-pro, gly-L-leu, L-leu-gly was investigated by measuring the short-circuit current in control rats and the rats 3 days after intraperitoneal injection of cyclophosphamide (CPM) 300 mg/kg. For determining active transport using the short-circuit current method in injured intestinal epithelia the short-circuit current measured should be corrected for the decrease in the mucosal resistance of CPM group. Jmax values for transport of glycine and L-alanine in ileum are significantly decreased in CPM group than in control group. Contrariwise, there are no differences in Jmax values for peptides transport in ileum between two groups. The results indicate that the glycine transport carrier is more sensitive to CPM injury than the peptide transport carrier for glycine-containing dipeptide, suggesting the clinical usefulness of the peptide nutrition during chemotherapy.
Hosoda
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Second Department of Internal Medicine, Shiga University of Medical Science.
Bamba
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Hosoda
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D000596:Amino Acids / Q000493:pharmacokinetics*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D004151:Dipeptides / Q000493:pharmacokinetics*; D004568:Electrodiagnosis; D007082:Ileum / Q000187:drug effects* / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D004151:Dipeptides; D003520:Cyclophosphamide