Interaction of mutant forms of the HIV-1 protease with substrate and inhibitors.
Darke
P L
PL
Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486.
Kohl
N E
NE
Hanobik
M G
MG
Leu
C T
CT
Vacca
J P
JP
Guare
J P
JP
Heimbach
J C
JC
Dixon
R A
RA
D000595:Amino Acid Sequence; D001665:Binding Sites; D004926:Escherichia coli / Q000235:genetics; D016333:HIV Protease / Q000235:genetics* / Q000378:metabolism; D017320:HIV Protease Inhibitors; D007700:Kinetics; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D009842:Oligopeptides / Q000737:chemistry; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology; D013379:Substrate Specificity
D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D011480:Protease Inhibitors; D016333:HIV Protease