Boundary and airlock design issues in aseptic facilities.
As more potentially hazardous biopharmaceutical and powder derivative products are being processed aseptically, the term "containment" in aseptic facility design must take on a broader definition. Contamination control must address not only protection of the product, but the protection of aseptic facility workers and of the surrounding environment as well. This paper will focus on design issues related to the physical boundaries (walls, ceilings, doors, etc.) that separate aseptic areas from other spaces within a facility with particular emphasis on the design of airlocks as "control points" for contamination control.
Lorenz
M R
MR
Kling-Lindquist Partnership, Inc., Philadelphia, Pennsylvania.
Robinson
J E
JE
D001207:Asepsis; D004340:Drug Contamination / Q000517:prevention & control*; D015195:Drug Design; D004345:Drug Industry; D005160:Facility Design and Construction; D006801:Humans; D011786:Quality Control