A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit.
We report a case of IgM-associated mesangial proliferative glomerulonephritis with microscopic hematuria and renal tubular dysfunction. On electron microscopy, a giant spherical deposit was observed in the glomerular paramesangial area. Deposition of C3 in the glomerular mesangial areas was not observed by immunofluorescence. IgM-associated mesangial proliferative glomerulonephritis is clinically characterized by nephrotic syndrome, mild proteinuria and/or hematuria, tubular dysfunction or renal failure, suggesting that it is considered to be a heterogeneous disorder.
Inokuchi
S
S
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Yokomatsu
M
M
Funabiki
K
K
Shirato
I
I
Nakayama
S
S
Yoshida
M
M
Tomino
Y
Y
Koide
H
H
D005260:Female; D005920:Glomerular Mesangium / Q000648:ultrastructure; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M; D008854:Microscopy, Electron; D008875:Middle Aged
D007075:Immunoglobulin M