title: Acylated derivatives of 1,5-benzodiazepines. Part II.
abstract: Acylated derivatives of 4-methyl-1H-tetrahydro-1,5-benzodiazepin-2-one (1) and of 2-methyl-4-phenyl-1H-tetrahydro-1,5-benzodiazepino-2-carboxylic acid ethyl ester (10) were synthesized and preliminarily tested on their central activity. Acylation was carried out with alpha, beta-unsaturated acid chlorides, dicarboxylic acid monoester monochlorides, and dicarboxylic acid dichlorides. Compounds 2, 3, 11 and 12 had analgesic, compounds 4, 11 and 12--anticonvulsant, and compounds 3 and 11--antiaggressive properties.
authors.affiliation: Department of Technology of Drugs, Medical Academy, Wrocłøaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Nawrocka
authors.forename: H
authors.initials: H
authors.lastname: Liszkiewicz
authors.forename: A
authors.initials: A
authors.lastname: Nawojski
authors.forename: M
authors.initials: M
authors.lastname: Wilimowski
authors.forename: L
authors.initials: L
authors.lastname: Kedzierska-Goździk
authors.forename: J
authors.initials: J
authors.lastname: Barczyńska
authors.forename: W
authors.initials: W
authors.lastname: Wojewódzki
authors.forename: E
authors.initials: E
authors.lastname: Duś
authors.forename: A
authors.initials: A
authors.lastname: Szelag
authors.forename: M
authors.initials: M
authors.lastname: Rutkowska
mesh_terms: D000215:Acylation; D000818:Animals; D001569:Benzodiazepines / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D006358:Hot Temperature; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D001569:Benzodiazepines; D010433:Pentylenetetrazole