title: Henoch-Schonlein syndrome in northern Indian children.
abstract: In order to evaluate clinical features and renal pathological findings of Henoch-Schonlein syndrome (HSS) in northern Indian Children, we studied 47 such cases. The mean age at onset was 8.5 yr; sex ratio (M:F) 2.6:1. The clinical features were purpuric rash (96%), abdominal pain (64%), Henoch-Schonlein nephritis (51%) and arthralgias (47%). Patients younger than 6 yr also showed urticarial rash or edema of scalp and extremities. Henoch-Schonlein nephritis (HSN) and abdominal symptoms were more common in older cases. The manifestations of HSN were asymptomatic hematuria and/or proteinuria (n = 15), acute nephritic syndrome (n = 6), and nephrotic syndrome (n = 3). The severity of clinical manifestations correlated with the renal pathologic findings. On follow up, 29% cases showed renal impairment. The prognosis was poor in patients with the acute nephritic or nephrotic syndrome and crescents in more than 50% glomeruli. Combination of clinical data and renal biopsy findings are important in assessing the long-term outcome in cases with HSN.
authors.affiliation: Department of Pediatrics, All India Institute of Medical Sciences, New Delhi.
authors.forename: A
authors.initials: A
authors.lastname: Bagga
authors.forename: S K
authors.initials: SK
authors.lastname: Kabra
authors.forename: R N
authors.initials: RN
authors.lastname: Srivastava
authors.forename: U N
authors.initials: UN
authors.lastname: Bhuyan
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D007194:India; D007592:Joint Diseases / Q000209:etiology; D008297:Male; D009393:Nephritis / Q000209:etiology; D012871:Skin Diseases / Q000209:etiology; D013577:Syndrome