A histopathological study of age-related changes of the left bundle branch in the human heart.
To study age-related changes in the left bundle branch (LBB), 32 autopsied hearts were examined histopathologically using serial sections according to the method of Lev. Each division of LBB was carefully studied, i.e., the anterior and posterior radiations and the proximal, middle, and distal portions of radiations. An increase of fibrosis and fatty infiltration were observed in the LBB with aging. There was a tendency for fibrosis to be more prominent in the proximal LBB at the site of transition from bundle branch cells to Purkinje cells.
Sakaguchi
Y
Y
First Department of Internal Medicine, Nara Medical University, Japan.
Kato
S
S
Kawamoto
A
A
Uemura
S
S
Sutani
T
T
Kagoshima
T
T
Ishikawa
H
H
Okada
R
R
D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002036:Bundle of His / Q000473:pathology*; D005355:Fibrosis; D006801:Humans; D008875:Middle Aged