Neuroleptic actions on the thyroid axis: different effects of clozapine and haloperidol.
Twenty-six in-patients treated for schizophrenia, were divided in two groups. The first group received haloperidol, 20-40 mg p.d., and the second, clozapine, 150-250 mg p.d. TRH-TSH test was performed by injecting 0.2 mg TRH. Four drug-free schizophrenic patients gave normal TSH response to TRH, as well as the group of patients treated with haloperidol. Contrary to that, the clozapine-treated group showed a blunted TSH response. The results obtained are discussed in terms of the different pharmacological profiles of haloperidol and clozapine, especially regarding their dopaminergic actions, alpha-adrenergic and serotonergic control upon thyroid axis.
Paunović
V R
VR
Institute of Psychiatry, University Clinical Centre, Belgrade, Yugoslavia.
Timotijević
I
I
Marinković
D
D
D000328:Adult; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012563:Schizophrenia, Paranoid / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D003024:Clozapine; D006220:Haloperidol; D013974:Thyroxine