Effect of 17 beta-estradiol and ovariectomy on enzymes of carbohydrate metabolism in regenerating mouse liver.
Effect of exogenous 17 beta-estradiol and ovariectomy was determined on the activities of some enzymes of carbohydrate metabolism in regenerating mouse liver. 17 beta-estradiol increased liver weight and the activities of these enzymes when given after partial hepatectomy whereas ovariectomy, performed 2 weeks prior to hepatectomy, reduced the activities significantly. Estradiol administration to ovariectomized-partially hepatectomized animals restored the activities of glycolytic enzymes but not of G6P-DH and malic enzyme. This indicates that estradiol acts as a stimulator of growth of proliferating liver as it does in target tissue.
Dixit
A
A
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Baquer
N Z
NZ
Rao
A R
AR
D000818:Animals; D050260:Carbohydrate Metabolism; D004958:Estradiol / Q000502:physiology*; D005260:Female; D008099:Liver / Q000201:enzymology*; D008115:Liver Regeneration; D051379:Mice; D010052:Ovariectomy
D004958:Estradiol