[The effect of exogenous interferon on the in vitro production of alpha- and gamma-interferon by the lymphocytes of patients with respiratory papillomatosis].
The influence of various interferon concentrations in vitro on alpha- and gamma-interferon production by lymphocytes of children suffering from respiratory papillomatosis was studied for optimization of interferon therapy. Most of the children with clinical improvement after interferon treatment showed proportional dependence of alpha-interferon production upon exogenous interferon concentrations and stability of gamma-interferon production. In children without clinical improvement, initial production of both interferons was reduced significantly in the absence of IF in the medium, but no changes occurred when exogenous interferon was present in the medium. The test proposed here may be used for the determination of patients' sensitivity to interferon and for individualization of interferon treatment schedules in other long-lasting recurrent diseases.
Grigorian
S S
SS
Pritsker
A D
AD
Onufrieva
E K
EK
Chireshkin
D G
DG
Ershov
F I
FI
D002478:Cells, Cultured / Q000187:drug effects / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology* / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000096:biosynthesis / Q000097:blood / Q000187:drug effects*; D007371:Interferon-gamma / Q000096:biosynthesis / Q000097:blood / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008297:Male; D010212:Papilloma / Q000276:immunology* / Q000628:therapy; D011994:Recombinant Proteins; D012142:Respiratory Tract Neoplasms / Q000276:immunology* / Q000628:therapy
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D007371:Interferon-gamma
Vliianie ékzogennogo interferona na produktsiiu al'fa- i gamma-interferona in vitro limfotsitami bol'nykh respiratornym papillomatozom.