Frequency-dependent neuromuscular blockade by textilotoxin in vivo.
The effect of stimulation frequency on the timecourse of neuromuscular blockade, following the administration of textilotoxin (20 micrograms/kg) or beta-bungarotoxin (50 micrograms/kg), was examined in the interdigital muscles of the hindlimb in anaesthetized mice. While the time of death was variable, neuromuscular blockade of the interdigital muscles occurred at the same time as respiratory failure with both textilotoxin and beta-bungarotoxin only at stimulation rates of 0.5 Hz and above. Textilotoxin (50 micrograms/kg) produced an increase in the heart rate prior to death but no change in the shape of the electrocardiogram.
Lloyd
D R
DR
Department of Pharmacology, University of Sydney, NSW, Australia.
Nicholson
G M
GM
Spence
I
I
Connor
M
M
Tyler
M I
MI
Howden
M E
ME
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002038:Bungarotoxins / Q000494:pharmacology; D003964:Diaphragm / Q000187:drug effects / Q000294:innervation; D004546:Elapid Venoms / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051379:Mice; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects; D010791:Phrenic Nerve / Q000187:drug effects
D002038:Bungarotoxins; D004546:Elapid Venoms; D009466:Neuromuscular Blocking Agents; C037525:textilotoxin