title: Hydroxylated metabolites of antidepressants.
abstract: Hydroxylated metabolites (OHMs) of antidepressant drugs are pharmacologically active. On chronic administration, unconjugated OHM plasma concentrations can be substantial compared to that of the parent compound, especially for secondary amine TCAs and bupropion. OHMs may contribute to toxicity and may contribute to, or attenuate, efficacy. Direct administration of OHMs may be associated with antidepressant effects.
authors.affiliation: New York Hospital-Cornell Medical Center, Westchester Division, White Plains.
authors.forename: R C
authors.initials: RC
authors.lastname: Young
mesh_terms: D000928:Antidepressive Agents / Q000378:metabolism* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D006900:Hydroxylation
chemical_list: D000928:Antidepressive Agents