An antihypertensive factor in the erythrocytes of essential hypertensive subjects--effects on blood pressure and calcium uptake by vascular tissue in rats.
An extract prepared from the erythrocytes of essential hypertensive subjects was found to significantly lower systolic blood pressure (SBP) in spontaneously (SHR) and renal hypertensive rats (RHR) following a single intravenous or intraperitoneal injection: The maximum SBP reduction was 42.8 mmHg in SHR and 38.3 mmHg in RHR. In contrast, this hypertensive factor (AHF) had little effect on normotensive Wistar Kyoto and Wistar rats. AHF was also found to significantly suppress Ca2+ uptake by vascular smooth muscle in the mesenteric artery and aorta of hypertensive and normotensive rats (P less than 0.05, respectively). Furthermore, AHF prepared from the erythrocytes of normotensive subjects was shown to have a similar effect.
Wu
G
G
Institute of Basic Medical Sciences, CAMS, Beijing.
Wen
Y
Y
Chen
M
M
Zhang
S
S
Zhou
L
L
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D004912:Erythrocytes / Q000737:chemistry*; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D006978:Hypertension, Renovascular / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008638:Mesenteric Arteries / Q000378:metabolism; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY
D002118:Calcium