title: Effects of lead on hepatocyte ultrastructure in Carassius carassius (L.) var. auratus.
abstract: Subcellular modifications in hepatocytes of Carassius carassius var. auratus subjected to 24 hr and 48 hr sublethal acute lead (5mg.1-1) exposure were studied by electron microscopy. Cytological alterations were observed after 24 hr of treatment and became more evident after 48 hr. Lead induced an increase in nuclear heterochromatin and alterations in mitochondria, endoplasmic reticulum and Golgi complex ultrastructure. Glycogen granula decreased, and secondary lysosomes and lipid droplets increased. Furthermore, intracytoplasmic lumina with microvilli-bearing surfaces and numerous autophagic vacuola were observed after 48 hr of exposure.
authors.affiliation: Department of Animal Biology, University of Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Franchini
authors.forename: E
authors.initials: E
authors.lastname: Barbanti
authors.forename: A M
authors.initials: AM
authors.lastname: Fantin
mesh_terms: D000818:Animals; D002843:Chromatin / Q000187:drug effects / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D006054:Goldfish / Q000033:anatomy & histology*; D006056:Golgi Apparatus / Q000187:drug effects / Q000648:ultrastructure; D007854:Lead / Q000009:adverse effects / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure*; D008247:Lysosomes / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure; D013997:Time Factors
chemical_list: D002843:Chromatin; D007854:Lead