title: Neuropharmacological studies on the venom of Vipera russelli.
abstract: Neuropharmacological studies have been conducted on the venom of V. russelli on experimental animals. The venom was found to produce alteration in general behaviour pattern, reduction in spontaneous motility, hypothermia, potentiation of pentobarbitone hypnosis, analgesia, reduction in exploratory behaviour pattern, muscle relaxant action, and suppression of aggressive behaviour. The venom caused a significant increase in brain GABA content in mice. The observations are suggestive of a potent CNS-depressant action of V. russelli venom.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
authors.forename: A S
authors.initials: AS
authors.lastname: Dutta
authors.forename: A K
authors.initials: AK
authors.lastname: Chaudhuri
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D010146:Pain / Q000188:drug therapy; D051381:Rats; D012640:Seizures / Q000188:drug therapy; D012890:Sleep / Q000187:drug effects; D014757:Viper Venoms / Q000494:pharmacology* / Q000633:toxicity; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis
chemical_list: D014757:Viper Venoms; D005680:gamma-Aminobutyric Acid; D002746:Chlorpromazine