title: Bilateral renal cortical necrosis in two patients with Neisseria meningitidis sepsis.
abstract: Two patients who developed bilateral renal cortical necrosis as a consequence of Neisseria meningitidis infections are described: 1 patient had meningococcemia and the other had meningococcal meningitis. Both patients developed a Shwartzman-like reaction, disseminated intravascular coagulation and irreversible renal failure. Renal biopsy showed sclerosis of the majority of glomeruli; some glomeruli showed capillary congestion, thrombosis and an increased number of neutrophils; the intralobular arterioles showed thrombotic occlusions.
authors.affiliation: Department of Medicine, University of Southern California, Los Angeles.
authors.forename: I
authors.initials: I
authors.lastname: Chervu
authors.forename: M
authors.initials: M
authors.lastname: Koss
authors.forename: V M
authors.initials: VM
authors.lastname: Campese
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D007673:Kidney Cortex Necrosis / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008585:Meningitis, Meningococcal / Q000150:complications* / Q000473:pathology; D008589:Meningococcal Infections / Q000150:complications* / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000473:pathology; D012790:Shwartzman Phenomenon / Q000473:pathology