title: Allele frequencies of human complement factor I in a sample from Iwate, northern Japan, with the description of geographical cline.
abstract: Serum samples from 270 healthy blood donors of Iwate prefecture, northern Japan, were examined for polymorphism of factor I (IF) by using polyacrylamide gel isoelectric focusing followed by semidry horizontal electroblotting with enzyme immunoassay. In 270 individuals four different patterns were observed, and these were controlled by two common alleles, IF*A and IF*B, and one rare allele, IF*A2. Allele frequencies were estimated to be 0.1019, 0.8963 and 0.0018 for IF*A, IF*B and IF*A2, respectively. The data of IF allele frequencies thus far reported in Japan excluding Okinawa Island were compared, and a statistically significant (p less than 0.01) geographical cline was detected for IF*A and IF*B alleles.
authors.affiliation: Department of Legal Medicine, Tokyo Women's Medical College, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Omoto
authors.forename: A
authors.initials: A
authors.lastname: Sawaguchi
mesh_terms: D000483:Alleles; D003172:Complement C1 / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D007525:Isoelectric Focusing; D007564:Japan
chemical_list: D003172:Complement C1; D005819:Genetic Markers