title: Ciprofloxacin versus gentamicin/clindamycin for postpartum endometritis.
abstract: An open, randomized, comparative study of intravenous ciprofloxacin versus gentamicin and clindamycin was performed on women with postpartum endometritis. Ciprofloxacin alone successfully eradicated the infections in 35 of 49 patients (71%), while the combination of gentamicin/clindamycin cured 41 of 48 (85%) (P = .15). The microbiology and antibiotic sensitivity of the endometrial isolates confirmed the poor activity of ciprofloxacin against anaerobic bacteria and less-than-optimal activity against Streptococcus faecalis. Ciprofloxacin, when used alone, may not be suitable for the treatment of postpartum endometritis.
authors.affiliation: Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: M L
authors.initials: ML
authors.lastname: Maccato
authors.forename: S
authors.initials: S
authors.lastname: Faro
authors.forename: M G
authors.initials: MG
authors.lastname: Martens
authors.forename: H A
authors.initials: HA
authors.lastname: Hammill
mesh_terms: D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D004716:Endometritis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D011645:Puerperal Infection / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology
chemical_list: D005839:Gentamicins; D002981:Clindamycin; D002939:Ciprofloxacin