Research on the distribution of properdin factor B in Sardinia.
This study examines the distribution of properdin factor B by means of electrophoresis on cellulose acetate in a sample of 780 individuals from seven historical/geographical areas of Sardinia: Nurra, Goceano, Nuorese, Arborea, Sarcidano, Ogliastra, Campidano di Cagliari. The gene frequencies obtained for the total sample are BF*S = 0.595, BF*F = 0.227, BF*S1 = 0.012, BF*F1 = 0.166. Division of the total sample into subsamples has highlighted some noticeable differences both among the historical/geographical areas considered and with mainland Italy. In Sardinia relatively low frequencies of the allele BF*S are accompanied by exceptionally high incidences of the variant allele BF*F1, which reaches a maximum in the Goceano area (0.2143).
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Department of Environmental Science, University of L'Aquila.
Brasili Gualandi
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Vona
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D000483:Alleles; D011415:Complement Factor B / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007558:Italy; D008522:Mediterranean Sea; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*
D005819:Genetic Markers; D011415:Complement Factor B