Neuropathologic and therapeutic studies in experimental spinal cord trauma.
Experimental spinal cord trauma was performed intraoperatively in 132 rabbits (Allen's method modified by Faden et al.). Only 77 animals were administered drugs (glucocorticoids, antioxidants and anti-inflammatory nonsteroids): Prednisolon, Fluocinolon-N-spray, Epurox, Ketazone, Rheopyrin and Rengasil. The remaining 55 animals were controls. Results were clinically (the assessment of lower limb movement was performed on a 5-score scale) and neuropathologically studied. From a clinical point of view, Prednisolon, Fluocinolon and Rengasil showed some beneficial effects. No significant differences of nervous fibre regeneration were noticed between probands and controls.
Anghelescu
N
N
Institute of Neurology and Psychiatry, Bucharest, Romania.
Petrescu
A
A
Alexandrescu
I
I
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D002374:Catalase / Q000627:therapeutic use; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D009416:Nerve Regeneration / Q000187:drug effects; D011817:Rabbits; D013116:Spinal Cord / Q000187:drug effects / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy / Q000473:pathology*; D013256:Steroids; D013482:Superoxide Dismutase / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D004338:Drug Combinations; D013256:Steroids; D002374:Catalase; D013482:Superoxide Dismutase; C050165:epurox