title: Biotransformation study of para-substituted phenylpiperazines in beagle dogs by gas chromatography-mass spectrometry.
abstract: 1. Beagle dogs were treated orally (10 mg/kg) with para-chloro-, para-fluoro- and para-methyl-phenylpiperazine derivatives, and urine was collected for 72 h after treatment. 2. Metabolites were extracted, converted into trimethylsilyl (TMS) derivatives and examined by g.l.c.-mass spectrometry. 3. The metabolites fall into two main groups, N-desphenylated metabolites, which result from N-desphenylation, and N-phenyl metabolites. 4. Two kinds of hydroxylated metabolites were found. Some lost the original para substituent (Cl, F or CH3); others retained it. 5. These results are consistent with the NIH shift reaction.
authors.affiliation: Groupe de recherches en biodynamique du médicament, Faculté de pharmacie de Clermont-Ferrand, France.
authors.forename: M J
authors.initials: MJ
authors.lastname: Galmier
authors.forename: J F
authors.initials: JF
authors.lastname: Pognat
authors.forename: C
authors.initials: C
authors.lastname: Lartigue-Mattei
authors.forename: J L
authors.initials: JL
authors.lastname: Chabard
authors.forename: M
authors.initials: M
authors.lastname: Bastide
authors.forename: N
authors.initials: N
authors.lastname: Busch
authors.forename: J A
authors.initials: JA
authors.lastname: Berger
mesh_terms: D000818:Animals; D001711:Biotransformation; D004285:Dogs; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D015394:Molecular Structure; D010879:Piperazines / Q000737:chemistry / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D010879:Piperazines