Chlorpropamide induced syndrome of inappropriate secretion of antidiuretic hormone.
This is a report of a patient who developed symptomatic hyponatraemia during chlorpropamide therapy for diabetes mellitus. The patient's clinical and biochemical abnormalities were corrected by withdrawal of chlorpropamide. This represents a drug induced, reversible form of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
Ravat
H K
HK
PD Hinduja National Hospital & Research Centre, Mahim, Bombay.
Joshi
V R
VR
D002747:Chlorpropamide / Q000009:adverse effects* / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000628:therapy; D008875:Middle Aged
D002747:Chlorpropamide