[Pathogenic mechanisms of acute pulmonary edema of hemodynamic origin in rats].
In normal anaesthetized rats (pentobarbital, 40 mg/kg i.p.), intravenous injection of a bolus of vasopressin (0.3 micrograms/kg) provoked a large increase in pulmonary and in systemic blood pressures. About three minutes later, some rats (60%) developed an acute pulmonary edema (OPA), froth appearing at the trachea. Other animals presented no OPA at the 4th minute following the injection, but OPA appeared immediately when bilateral vagotomy was performed at that time. Factors explaining the appearance of OPA are mechanical ones, circulatory or respiratory, without interferences with autonomous nervous processes.
Lagneaux
D
D
Institut Léon Fredericq, Université de Liège.
Lecomte
J
J
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000502:physiology; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins
D014667:Vasopressins
Mécanismes pathogéniques de l'oedème pulmonaire aigu d'origine hémodynamique chez le rat.