[Effects of zixoryn on pharmacokinetics of antipyrine in intact and sensitized guinea pigs].
The effect of zixoryn, a hepatic inductor of cytochrome P-450, on the pharmacokinetics of antipyrine in intact and sensibilized guinea-pigs was studied. It was found that sensibilization of albumin increased the half-time (T1/2), AUC and decreased the total body clearance (Clt) of antipyrine and the renal clearance (Clr) of metabolites in urine. The administration of zixoryn in sensibilized animals decreased T1/2 and AUC and increased the clearance of antipyrine and its metabolites.
Khlopushina
T G
TG
Krinskaia
A V
AV
Kovalenko
L P
LP
Zherdev
V P
VP
Val'dman
A V
AV
D000818:Animals; D000983:Antipyrine / Q000378:metabolism / Q000493:pharmacokinetics*; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D004790:Enzyme Induction / Q000187:drug effects*; D005512:Food Hypersensitivity / Q000201:enzymology / Q000378:metabolism*; D006168:Guinea Pigs; D008297:Male
D001559:Benzhydryl Compounds; D003577:Cytochrome P-450 Enzyme System; C016914:flumecinol; D000983:Antipyrine
Vliianie ziksorina na farmakokinetiku antipirina u intaktnykh i sensibilizirovannykh morskikh svinok.