Dual-isotope imaging of neutron-activated erbium-171 and samarium-153 and the in vivo evaluation of a dual-labeled bilayer tablet by gamma scintigraphy.
The feasibility of dual-label scintigraphic studies which use the neutron-activated isotopes erbium-171 and samarium-153 is described. Experimental details are provided to correct and minimize the compton scatter contribution of 171Er into the lower-energy 153Sm window. The results from this study demonstrate that this dual-label procedure is sensitive enough to monitor simultaneously the behavior of two discrete regions of the same unit dose in the gastrointestinal tract of man.
Digenis
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GA
Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536-0082.
Sandefer
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EP
Beihn
R M
RM
Parr
A F
AF
D004064:Digestive System / Q000000981:diagnostic imaging; D004871:Erbium; D005772:Gastrointestinal Transit; D006801:Humans; D007553:Isotope Labeling; D009501:Neutron Activation Analysis; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012493:Samarium; D013607:Tablets
D011868:Radioisotopes; D013607:Tablets; D012493:Samarium; D004871:Erbium