Is there a role for reactive oxygen species in the mechanism of chromium(VI) carcinogenesis?
Standeven
A M
AM
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire.
Wetterhahn
K E
KE
D000818:Animals; D002273:Carcinogens; D002857:Chromium / Q000378:metabolism / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D004249:DNA Damage; D005978:Glutathione / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D009153:Mutagens; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*
D002273:Carcinogens; D009153:Mutagens; D002857:Chromium; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione; D010100:Oxygen