[The effect of potential antineoplastic antibiotics and the metal complex compound cisplatin on in vitro phagocytosis].
Under standardized conditions the influence of the drugs lambdamycin, violamycin, granatomycin C, daunorubicin and cisplatin on the phagocytosis has been tested. Therapeutical doses of lambdamycin, daunorubicin and cisplatin did not have any obvious impairment on the phagocytosis. Contrarily to this granatomycin C (an isochromanchinon antibiotic) and violamycin (an anthracyclin in high concentrations) significantly depressed the phagocytosis of PMN.
Egerer
R
R
Institut für Mikrobiologie und Experimentelle Therapie (IMET) Jena.
Stelzner
A
A
Süss
J
J
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001578:Benzopyrans; D002945:Cisplatin / Q000494:pharmacology*; D003630:Daunorubicin / Q000494:pharmacology; D006027:Glycosides; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects; D009285:Naphthoquinones / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects*; D000095622:Benzoisochromanequinones
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; D002945:Cisplatin; D003630:Daunorubicin; D006027:Glycosides; D009285:Naphthoquinones; C010806:violamycins; C009811:granaticin; D000095622:Benzoisochromanequinones; C002185:chartreusin
Der Einfluss potentiell antineoplastisch wirksamer Antibiotika und der Metallkomplexverbindung Cisplatin auf die in vitro-Phagozytose.