title: Human eccrine sweat gland. Expression of neuroglandular antigens and coexpression of intermediate filaments.
abstract: Acrosyringium, duct and secretory epithelium as well as myoepithelial cells of human eccrine sweat glands have been characterized by different immunostaining patterns with mono- and polyclonal antibodies to a wide spectrum of tissue antigens. Using monoclonal antibodies to neuron-specific enolase (NSE) and melanoma-associated antigens (LS 59, HMB-45, NKI/C-3) the expression of neuroectodermal antigens in secretory coils was demonstrated. Myoepithelial cells were double-stained with polyclonal vimentin and monoclonal CAM 5.2 (against keratins nos. 8, 18, 19) antibodies.
authors.affiliation: Department of Dermatology, University of Köln, F.R.G.
authors.forename: U
authors.initials: U
authors.lastname: Wollina
mesh_terms: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D001706:Biopsy; D002462:Cell Membrane / Q000737:chemistry / Q000648:ultrastructure; D003238:Connective Tissue / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis*; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis*; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D013545:Sweat Glands / Q000737:chemistry* / Q000502:physiology / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis*
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D007381:Intermediate Filament Proteins; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase