title: [Wegener's granulomatosis--evaluation of diagnostic problems and the progress in its treatment based on the review of 54 cases published in Poland in 1959-1990].
abstract: 54 cases of Wegener's granulomatosis published in Polish literature in 1959-1990 are presented. There were 37 women and 17 men from 17 to 70 years of age. The diagnosis was histologically proved during life in 30 cases and by autopsy in 14 others. In 10 patients it was based on clinical symptoms only. Diagnosis was established after 1 months to 4 years of symptoms, mean equals 10.3 months. The delay of diagnosis was caused by the ineffectiveness of biopsy, usually from the upper airways and also by the wrong interpretation of histopathological pictures. All patients had upper airways disease, 56% of patients had lung involvement, 66% renal lesions, 37%--eye changes, 35% skin lesions and 11%--nervous system involvement. In addition in 83% of patients systemic symptoms were observed. The prognosis of WG ameliorate with the time of publications due to cyclophosphamide and other cytotoxic drugs introduction to WG treatment.
authors.affiliation: III Kliniki Gruźlicy i Chorób Płuc Instytutu Gruźlicy i Chorób Płuc.
authors.forename: E
authors.initials: E
authors.lastname: Wiatr
authors.forename: E
authors.initials: E
authors.lastname: Decker
authors.forename: A
authors.initials: A
authors.lastname: Siekierzyńska-Czarnecka
authors.forename: Z
authors.initials: Z
authors.lastname: Billip-Tomecka
authors.forename: R
authors.initials: R
authors.lastname: Gellert
authors.forename: E
authors.initials: E
authors.lastname: Rowińska-Zakrzewska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D005128:Eye Diseases / Q000175:diagnosis; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis; D008171:Lung Diseases / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D006435:Renal Dialysis; D012871:Skin Diseases / Q000175:diagnosis; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Ziarniniakowatość Wegenera--problem diagnostyczny i postep w leczeniu na podstawie przegladu 54 przypadków opublikowanych w latach 1959-1990 w Polsce.