[Immunomodulating peptides, regulation of interleukin-2 expression and its possible mechanism].
The influence of some immunomodulation peptides SKD, R and L on the interleukin-2 (IL-2) synthesis in T-lymphocytes and possibility of their specific interaction with nucleotide sequences of IL-2 gene were studied. It was firstly shown that peptides R and L specifically interacted with regulatory nucleotide sequences of IL-2 gene and, possibly, play a key role in the immunomodulation actions on the IL-2 production.
Kazakova
T B
TB
Miul'berg
A A
AA
Burov
S V
SV
Golovko
O I
OI
Grishina
T V
TV
Morozov
V M
VM
Neustroeva
L Ch
LCh
Gushchin
G V
GV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D007376:Interleukin-2 / Q000096:biosynthesis / Q000235:genetics*; D051379:Mice; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism
D000276:Adjuvants, Immunologic; D007376:Interleukin-2
Immunomoduliruiushchie peptidy, reguliatsiia obrazovaniia interleĭkina-2 i vozmozhnyĭ ee mekhanizm.