title: [Effect of humoral factors of the spleen of rats with acute and chronic toxic liver involvement on the physiologic and reparative regeneration of hepatocytes].
abstract: It was demonstrated in experiments on Wistar rats with carbon tetrachloride induced acute and chronic affection of the liver that the supernatant of the splenic cells of the poisoned animals contains 2 undialyzable factors with a molecular mass of more than 150 and 10-12 kDa. The splenocytic substances stimulate hepatocyte proliferation both in healthy allogeneic recipients and under conditions of increased proliferative activity of hepatocytes in experimental pathology of the liver.
authors.forename: A I
authors.initials: AI
authors.lastname: Konoplia
authors.forename: I A
authors.initials: IA
authors.lastname: Shveĭnov
authors.forename: L G
authors.initials: LG
authors.lastname: Prokopenko
authors.forename: E N
authors.initials: EN
authors.lastname: Konoplia
mesh_terms: D000208:Acute Disease; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000503:physiopathology*; D002908:Chronic Disease; D005260:Female; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D011506:Proteins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000737:chemistry*
chemical_list: D011506:Proteins
vernacular_title: Vliianie gumoral'nykh faktorov selezenki krys s ostrym i khronicheskim toksicheskim porazheniem pecheni na fiziologicheskuiu i reparativnuiu regeneratsiiu gepatotsitov.