Correlation of the gastric emptying of nondisintegrating tablets with gastrointestinal motility.
The aim of the present study was to correlate the gastric emptying (GE) of nondisintegrating tablets with changes in gastrointestinal (GI) motility. Eight, healthy, male subjects each received 5 x 7-mm radiolabeled tablets, a radiolabeled meal, and a radiotelemetry capsule (RTC). Transit of the radiolabeled formulations was followed by gamma scintigraphy and the RTC detected contractile activity in the GI tract. The study demonstrated that 7-mm tablets can empty from the fed stomach, prior to the onset of interdigestive activity. Those tablets that were not emptied during fed activity were retained through the period of quiescence associated with the onset of the migrating myoelectric complex (MMC) and left the stomach during contractions associated with phase 2 and 3 activity. The RTC was retained in the stomach and was emptied only by large phase 3 contractions commonly termed the "housekeeper" wave. However, in one subject, the RTC was retained in the stomach for over 12 hr, during which time three distinct phase 3 complexes were monitored.
Coupe
A J
AJ
Department of Pharmaceutical Sciences, School of Pharmacy, Nottingham University, Notts, UK.
Davis
S S
SS
Evans
D F
DF
Wilding
I R
IR
D000328:Adult; D002482:Cellulose / Q000031:analogs & derivatives; D005746:Gastric Emptying / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000502:physiology; D011877:Radionuclide Imaging; D013270:Stomach / Q000000981:diagnostic imaging / Q000502:physiology; D013607:Tablets; D013686:Telemetry
D007205:Indium Radioisotopes; D013607:Tablets; C013517:ethyl cellulose; D002482:Cellulose