[Renin-angiotensin-aldosterone system and vasopressin in adult and aged patients with acquired mitral valve defects].
Seventy four patients aged 35-74 years who had mitral valvular disease were examined for renin, angiotensin II, aldosterone, and vasopressin, of whom 49 patients were diagnosed as having a mitral valve defect with prevalent stenosis, 25 presented with a mitral valve defect with prevalent heart failure. Circulatory disorders, Stages I-II, were found in 41 patients, Stage IIB in 23, and Stage III in 10 patients. There were no significant differences in the parameters of the renin-angiotensin-aldosterone system (RAAS) and vasopressin in untreated adult and elderly patients with mitral valvular disease at rest. As circulatory disorders progressed, the RAAS parameters significantly increased in all the groups. However, the patients with prevalent stenosis showed higher blood renin levels than did those with prevalent heart failure, irrespective of its severity. In refractory heart failure, the significant differences remained to a greater extent only for renin. The treatment with peripheral vasodilators (isosorbide dinitrate and corinfar) resulted in compensatory activation of the neurohumoral vasoconstrictive system, thereafter the RAAS parameters significantly increased after the drugs.
Danilov
A A
AA
Grigor'iants
R A
RA
Masenko
V P
VP
Mukharliamov
N M
NM
D000328:Adult; D000367:Age Factors; D000368:Aged; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000097:blood* / Q000145:classification / Q000503:physiopathology; D008946:Mitral Valve Stenosis / Q000097:blood* / Q000145:classification / Q000503:physiopathology; D012084:Renin-Angiotensin System; D014667:Vasopressins / Q000097:blood*
D014667:Vasopressins
Renin-angiotenzin-al'dosteronovaia sistema i vazopressin u bol'nykh zrelogo i pozhilogo vozrasta s priobretennym mitral'nym porokom serdtsa.