title: The radiobiological significance of spatial and temporal distribution of energy absorbed from ionizing radiations.
abstract: The cells of higher organisms respond in a non-linear fashion to the energy absorbed from ionizing radiation. However, there appears to be no indication of a dependence that is of a higher power than the square of the absorbed energy. This relatively simple alternative permits operational definitions of two types of injuries, termed lesions and sublesions, and a basic description in terms of dual radiation action. There are, however, various complicating factors and uncertainties. Further progress requires the development of a modified microdosimetry that incorporates energy transport, a more complete treatment of saturation and especially a specific identification of what is probably damage to DNA.
authors.forename: H H
authors.initials: HH
authors.lastname: Rossi
mesh_terms: D000818:Animals; D002477:Cells / Q000528:radiation effects*; D004247:DNA / Q000528:radiation effects; D004249:DNA Damage; D004735:Energy Transfer; D008962:Models, Theoretical; D011839:Radiation, Ionizing
chemical_list: D004247:DNA