In vivo effects of RU41740 in aged humans: evaluation of some immunological parameters.
The immunological effects of the oral administration of RU41740 in hypo-anergic aged humans are reported. Significant restoration of cellular immunity, evaluated by skin tests, and increase of percentage of CD3+, CD2+, CD4+ and HNKI+ lymphocytes and phagocytic activity are demonstrated.
Afeltra
A
A
Institute of Clinica Medica IIII, University of Rome, La Sapienza.
Amoroso
A
A
Ferri
G M
GM
Basso
P
P
Guidi
G
G
Bonomo
L
L
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D001426:Bacterial Proteins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy*; D008297:Male; D010587:Phagocytosis / Q000187:drug effects
D000276:Adjuvants, Immunologic; D001426:Bacterial Proteins; C037567:glycoprotein, Klebsiella pneumoniae