Dissociation of haloperidol-induced "anhedonia" and catalepsy by lesions of the dorsal raphe nucleus.
Electrolytic lesions of the dorsal raphe nucleus were found to attenuate haloperidol-induced catalepsy, but did not alter haloperidol's ability to suppress the intake of a highly palatable saccharin/glucose mixture by nondeprived rats. These results suggest that neuroleptic-induced suppression of the drinking of palatable fluids is not secondary to the types of motor deficits that result in catalepsy.
Wirtshafter
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Department of Psychology, University of Illinois, Chicago 60680.
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D000818:Animals; D002375:Catalepsy / Q000209:etiology* / Q000503:physiopathology; D018492:Dopamine Antagonists; D004326:Drinking / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D010684:Philosophy; D011903:Raphe Nuclei / Q000293:injuries / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology
D018492:Dopamine Antagonists; D006220:Haloperidol