[Intoxication with tricyclic antidepressive agents in therapeutic doses. Benefits of routine blood level measurements].
Measurement of the level of tricyclic antidepressants in the blood is useful in the treatment of affective disorders. We describe four patients, all of whom became intoxicated by the recommended therapeutic doses of tricyclic antidepressants. The only obvious sign of such gradual intoxication may be worsening of the depressive syndrome. Therefore, to enable administration of high enough doses without intoxication we recommend routine blood level measurements. We present therapeutic ranges and intoxication levels, based on the international literature.
Svoen
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N
Psykiatrisk klinikk, Sentralsjukehuset i Sogn og Fjordane, Førde.
Bergsholm
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P
Martinsen
E W
EW
D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000097:blood / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008875:Middle Aged
D000929:Antidepressive Agents, Tricyclic
Intoksikasjon med tricykliske antidepressiva i terapeutiske doser. Nytten av rutinemessig måling av serumnivå.