Antimicrobial diterpenes of Croton sonderianus, 1. Hardwickic and 3,4-secotrachylobanoic acids.
The hexane-extracted resin of the roots of Croton sonderianus showed antimicrobial activity in standardized bioassays. Fractionation of the resin yielded two acid diterpenes, (-)-hardwickic acid [2] and the new 3,4-secotrachylobanoic acid [5] as major bioactive materials.
McChesney
J D
JD
Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.
Clark
A M
AM
Silveira
E R
ER
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D004224:Diterpenes; C074342:3,4-secotrachylobanoic acid; C074343:hardwickic acid