[The efficacy of ribamidil in experimental RS-virus infection].
The antiviral activity of a national analogue of virasol, ribamydil, with regard to RS virus infection was studied in tissue culture and in experimental animals. In L-41 cell cultures ribamydil in a dose of 60 micrograms/ml or more completely inhibited multiplication of RS virus strain Long, in a titre of 4.75 lg CPD50. The drug concentrations of 30, 15, and 7 micrograms/ml reduced the virus content by 3.75, 2.75 and 2.0 lg CPD50, respectively; ED50 of the drug was 7 micrograms/ml, the chemotherapeutic index was 71. In cotton rats, RS virus infection could be reproduced in 95%. Subcutaneous inoculation of the injection form of ribamydil in a dose of 100 mg/kg body weight prevented the development of infection with RS virus in 100% of the animals.
Guseva
V M
VM
Chizhov
N P
NP
D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects / Q000382:microbiology; D004353:Drug Evaluation, Preclinical; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D010253:Respirovirus Infections / Q000188:drug therapy*; D012254:Ribavirin / Q000494:pharmacology / Q000627:therapeutic use*; D016205:Sigmodontinae; D013997:Time Factors; D014776:Virus Cultivation
D012254:Ribavirin
Izuchenie éffektivnosti ribamidila pri éksperimental'noĭ RS-virusnoĭ infektsii.