title: Chymotrypsin-catalyzed fragment coupling synthesis of GnRH-analogs.
abstract: D-Xaa6-GnRH analogs (Xaa: Ala, Nal1), Phe, Ser(tBu), Trp) were prepared by chymotrypsin catalyzed 3 + 7 fragment coupling synthesis with conversion rates of the amino component in the range from 90.3 to 97.4%. For D-Phe6-GnRH the method was scaled up to production level.
authors.affiliation: Berlin-Chemie AG, Berlin.
authors.forename: A
authors.initials: A
authors.lastname: Hänsicke
authors.forename: E
authors.initials: E
authors.lastname: Krause
authors.forename: M
authors.initials: M
authors.lastname: Bienert
authors.forename: M
authors.initials: M
authors.lastname: Schmidt
authors.forename: S
authors.initials: S
authors.lastname: Kobert
authors.forename: V
authors.initials: V
authors.lastname: Schellenberger
authors.forename: H D
authors.initials: HD
authors.lastname: Jakubke
authors.forename: K D
authors.initials: KD
authors.lastname: Kaufmann
mesh_terms: D002384:Catalysis; D002918:Chymotrypsin / Q000737:chemistry; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry
chemical_list: D009842:Oligopeptides; D007987:Gonadotropin-Releasing Hormone; D002918:Chymotrypsin