[Activation of lipid peroxidation in early degeneration of motor nerve fibers and the effect of antioxidants on its development].
It was established that early degeneration of motor fibers of the sciatic nerve of rats (24 and 48 hours after division) is marked by diminished activity of the antioxidant enzymes superoxide dismutase and glutathione reductase and activation of lipid peroxidation leading to increased accumulation of malonic dialdehyde. alpha-tocopherol acetate prevents activation of lipid peroxidation and partly suppresses the development of functional signs of degeneration (lowered amplitude of the M-response, slow restoration of the neuromuscular synapse, and decrement reaction to rhythm stimulation). OBQ2 oxidant (derivative of 4-anilino-5-methoxy-1,2-benzoquinone) had no effect on the rate of degeneration development, which is evidence of insufficiency of radical protection for realization of the anti-degeneration effect.
Shalatonin
V T
VT
Petrasgevskaya
N N
NN
Chernova
T O
TO
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009045:Motor Endplate / Q000187:drug effects*; D009410:Nerve Degeneration / Q000187:drug effects*; D009412:Nerve Fibers / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants
Aktivatsiia perekisnogo okisleniia lipidov pri ranneĭ degeneratsii dvigatel'nykh nervnykh volokon i vliianie antioksidantov na ee razvitie.