The effect of tacrine (THA) on cycloheximide- and basal forebrain lesion-induced memory deficit in rats.
The effects of 9-amino-1,2,3,4-tetrahydroacridine (tacrine), an active acetylcholinesterase inhibitor, on cycloheximide- and basal forebrain (BF) lesion-induced memory deficit in the water maze and passive avoidance task were investigated. While cycloheximide (1.5 mg/kg, s.c.) produced amnesia in the passive avoidance task, chronic administration of tacrine (1, 3 and 10 mg/kg, once a day for 1 week) improved the amnesia. BF lesion produced amnesia in both the water maze and passive avoidance tasks. Chronic tacrine (0.1-3 mg/kg, passive avoidance task, or 0.3 mg/kg, water maze task, once a day for 1 week) improved BF lesion-induced amnesia in the passive avoidance and water maze tasks. These results suggest that tacrine may be useful for senile dementia.
Nabeshima
T
T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Maruyama
E
E
Katoh
A
A
Kameyama
T
T
D000284:Administration, Oral; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D001037:Aphasia / Q000209:etiology; D001259:Ataxia / Q000209:etiology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001927:Brain Diseases / Q000139:chemically induced / Q000150:complications / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003513:Cycloheximide; D004305:Dose-Response Relationship, Drug; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D016548:Prosencephalon / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013619:Tacrine / Q000494:pharmacology*
D013619:Tacrine; D003513:Cycloheximide; D002795:Choline O-Acetyltransferase