Analysis and pharmacotoxicity of feruloyltyramine as a new constituent and p-coumaroyltyramine in Cannabis sativa L.
Feruloyltyramine (FT), a new amide compound, together with p-coumaroyltyramine (p-CT) was isolated and identified in ethanol extract of cannabis seeds. FT and p-CT were also detected in the roots, leaves and resin of Cannabis sativa L. The intracerebroventricular injection of these amides caused hypothermia and motor incoordination in mice, and the maximal effects were caused 160 to 240 min after the injection. Furthermore, p-CT also exhibited cataleptogenic effect in mice, although FT did not show any effect. These results suggest that these amide compounds may be responsible for some pharmacotoxicity of marihuana.
Yamamoto
I
I
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanagawa, Japan.
Matsunaga
T
T
Kobayashi
H
H
Watanabe
K
K
Yoshimura
H
H
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002188:Cannabis / Q000737:chemistry*; D002375:Catalepsy / Q000139:chemically induced; D002851:Chromatography, High Pressure Liquid; D003373:Coumaric Acids / Q000032:analysis / Q000633:toxicity*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D011597:Psychomotor Performance / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D014439:Tyramine / Q000031:analogs & derivatives* / Q000032:analysis / Q000633:toxicity
D003373:Coumaric Acids; C001411:N-(4-hydroxy-beta-phenethyl)-4-hydroxycinnamide; D010936:Plant Extracts; C074004:feruloyltyramine; D014439:Tyramine