title: The diphosphonate space: a useful quantitative index of disease activity in patients undergoing hydroxy methylene diphosphonate (HMDP) bone imaging for Paget's disease [corrected].
abstract: Comparison between the plasma levels of intravenously injected technetium 99m hydroxy methylene [corrected] diphosphonate (99mTc-HMDP) and chromium 51 ethylene diamine tetra-acetic acid (51Cr-EDTA) reflects the uptake of diphosphonate into bone (the diphosphonate space). This can be used as an index of skeletal function in metabolic bone disease. In a series of 49 patients with Paget's disease the diphosphonate space (DPS) correlated well with other indicators of disease activity such as alkaline phosphatase and urinary hydroxyproline levels. The DPS is a good predictor of the volume of skeletal involvement as estimated from bone images. The DPS also provides a sensitive indicator of response to treatment with intravenously administered bisphosphonate. The DPS is simple to perform and is a useful adjunct to routine bone imaging.
authors.affiliation: Department of Radiology, University Hospital, Queen's Medical Centre, Nottingham, UK.
authors.forename: A
authors.initials: A
authors.lastname: Evans
authors.forename: A
authors.initials: A
authors.lastname: Perkins
authors.forename: M
authors.initials: M
authors.lastname: Wastie
authors.forename: M
authors.initials: M
authors.lastname: Stone
authors.forename: D
authors.initials: D
authors.lastname: Hosking
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002860:Chromium Radioisotopes; D004492:Edetic Acid; D006801:Humans; D010001:Osteitis Deformans / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives
chemical_list: D002860:Chromium Radioisotopes; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D004492:Edetic Acid; D000469:Alkaline Phosphatase; D013669:Technetium Tc 99m Medronate