title: Effects of ethyl 4-chloro-2-methylphenoxyacetate on hepatic peroxisomal enzymes in rats.
abstract: Effects of ethyl 4-chloro-2-methylphenoxyacetate (MCPA) and clofibrate on the activities of hepatic lipid metabolizing enzymes in the peroxisomal fraction from rat liver were studied, and these drugs were found to potentiate the peroxisomal enzyme activity. The results imply that MCPA affects lipid metabolism as well as clofibrate.
authors.affiliation: Toxicology Section, Central Research Laboratories, Hokuriku Seiyaku Co., Ltd., Fukui.
authors.forename: N
authors.initials: N
authors.lastname: Inomata
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Aoki
authors.forename: M
authors.initials: M
authors.lastname: Tsunoda
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis; D001661:Biliary Tract Neoplasms / Q000139:chemically induced; D002994:Clofibrate / Q000633:toxicity; D006540:Herbicides / Q000633:toxicity*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001647:Bile Acids and Salts; D006540:Herbicides; D008456:2-Methyl-4-chlorophenoxyacetic Acid; D002994:Clofibrate