title: [The structure and anthelmintic action of tricyclic analogs of praziquantel and 4-acylpiperazinones-2].
abstract: The toxicity and anthelminthic activity of the earlier synthetized tricyclic analogues of praziquantel and 4-acylpiperazinones-2 have been studied. Tricyclic compounds have shown the acute toxicity similar to that of praziquantel and neurotoxic effect typical of praziquantel. 4-acylpiperazinones-2 toxicity correlated with their anthelminthic effect. The determination of anthelminthic activity of the above compounds in opisthorchiasis and hymenolepiasis has shown that they are less effective than praziquantel or have no anthelminthic activity. A biological activity-structure relationship has been traced in the compounds under study.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Tsizin
authors.forename: N L
authors.initials: NL
authors.lastname: Sergovskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Shekhter
authors.forename: S A
authors.initials: SA
authors.lastname: Cherniak
authors.forename: M N
authors.initials: MN
authors.lastname: Lebedeva
authors.forename: N D
authors.initials: ND
authors.lastname: Lychko
authors.forename: A I
authors.initials: AI
authors.lastname: Krotov
authors.forename: D G
authors.initials: DG
authors.lastname: Baiandina
authors.forename: G N
authors.initials: GN
authors.lastname: Kazantseva
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use / Q000633:toxicity*; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D005260:Female; D006925:Hymenolepiasis / Q000188:drug therapy; D007928:Lethal Dose 50; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009889:Opisthorchiasis / Q000188:drug therapy; D010879:Piperazines / Q000627:therapeutic use / Q000633:toxicity*; D011223:Praziquantel / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000871:Anthelmintics; D010879:Piperazines; D011223:Praziquantel
vernacular_title: Stroenie i antigel'mintnaia aktivnost' tritsiklicheskikh analogov prazikvantelia i 4-atsilpiperazinonov-2.