Distribution of cadmium in ovaries, adrenals and pituitary gland after chronic administration in rats.
Wistar rats were given 0.25, 0.5 or 1.0 mg/kg/week CdCl2 for 14, 18 or 22 weeks and the body weight, Cd content of ovaries, adrenals, pituitary gland, furthermore the progesterone and oestradiol-17 beta secretion of ovary were checked. Cd treatment caused a slight decrease in the body weight, but failed to alter the weight of endocrine organs. CdCl2 in a dose of 0.25 mg/kg/week resulted in almost the same Cd content in all the three organs. Rising the amount of Cd administered the pituitary gland accumulated more Cd than the adrenals, and the lowest levels were found in the ovary. CdCl2 even in the dose of 1.0 mg/kg/week failed to alter the ovarian cycle, progesterone and oestradiol-17 beta production of ovary. The data point also to a developing tolerance to Cd as the cumulative dose of CdCl2 lies close to the LD50 levels.
Varga
B
B
Department of Experimental Toxicology, National Institute of Occupational Health, Budapest, Hungary.
Paksy
K
K
Náray
M
M
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000493:pharmacokinetics* / Q000633:toxicity; D004958:Estradiol / Q000097:blood; D005260:Female; D006439:Hemodynamics; D007279:Injections, Subcutaneous; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism*; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D002104:Cadmium; D011374:Progesterone; D004958:Estradiol