Structural characterization of the urinary metabolites of iprindole in rat.
1. The in vivo metabolism of iprindole in rat is described. Each rat received a single dose of iprindole (10 mg/kg) and urine was collected for 48 h. 2. Fourteen metabolites of iprindole were isolated from rat urine after enzymic hydrolysis and their structures were determined by a computerized g.l.c.-mass spectrometric technique, before and after appropriate chemical derivatization. 3. Three concurrent metabolic pathways have been identified for iprindole in rat; aromatic ring hydroxylation is a minor pathway. 4. This is the first reported comprehensive study on the in vivo metabolism of iprindole in rat.
Coutts
R T
RT
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
Hussain
M S
MS
Baker
G B
GB
Daneshtalab
M
M
Micetich
R G
RG
D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D007488:Iprindole / Q000737:chemistry / Q000378:metabolism / Q000652:urine*; D008297:Male; D015394:Molecular Structure; D051381:Rats; D011919:Rats, Inbred Strains
D007488:Iprindole