title: Exacerbation of myasthenia gravis shortly after administration of methimazole for hyperthyroidism.
abstract: We report a case of myasthenia gravis (MG) which became worse shortly after the administration of methimazole (MMI) for hyperthyroidism. The activation of immune responses was found during the worsening of MG. The findings suggests the possibility that the worsening of MG might be induced by MMI, presumably by its immunomodulatory property.
authors.affiliation: Department of Internal Medicine (Section of Neurology), Saga Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroda
authors.forename: C
authors.initials: C
authors.lastname: Endo
authors.forename: R
authors.initials: R
authors.lastname: Neshige
authors.forename: R
authors.initials: R
authors.lastname: Kakigi
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects; D000328:Adult; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008713:Methimazole / Q000009:adverse effects*; D009157:Myasthenia Gravis / Q000150:complications* / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D008713:Methimazole