Central cholinergic agents. II. Synthesis and acetylcholinesterase inhibitory activities of N-[omega-[N-alkyl-N-(phenylmethyl)amino]alkyl]-3-arylpropenamides.
A series of N-[omega-[N-alkyl-N-(phenylmethyl)amino]alkyl]-3-arylpropenamides was prepared and tested for its inhibitory activities on acetylcholinesterase. Some in the series were found to be potent inhibitors. The structure-activity relationships were discussed in detail.
Ishihara
Y
Y
Chemistry Research Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.
Kato
K
K
Goto
G
G
D000110:Acetylcholinesterase / Q000378:metabolism; D000178:Acrylamides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D010277:Parasympathomimetics / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000178:Acrylamides; D002800:Cholinesterase Inhibitors; D007211:Indoles; D010277:Parasympathomimetics; D000110:Acetylcholinesterase