The effect of aluminium chloride upon the transition of drugs through the blood-brain barrier into the central nervous system.
In order to determine the effect of Al3+ upon the transition of drugs through the blood-brain barrier into the central nervous system we examined its effect upon a drug that dissociates as a cation (quinidine) and drugs that dissociate as anions (acetylsalicylic acid and pentobarbital). The entry and exit of quinidine into and out of the brain in mice pre-treated with AlCl3 was inhibited. Al3+ did not compete with acetylsalicylic acid for the penetration through the blood-brain barrier but did slow down its elimination from the brain. Brain kinetics of the examined drugs showed good correlation with their central pharmacodynamic effects.
Jakovljević
V
V
Department of Pharmacology and Toxicology, Medical Faculty, University of Novi Sad, Yugoslavia.
Banić
B
B
Radunović
A
A
D000535:Aluminum / Q000494:pharmacology*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D001241:Aspirin / Q000493:pharmacokinetics* / Q000494:pharmacology; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D002712:Chlorides / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D010424:Pentobarbital / Q000493:pharmacokinetics / Q000494:pharmacology; D011802:Quinidine / Q000493:pharmacokinetics* / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D000535:Aluminum; D010424:Pentobarbital; D011802:Quinidine; D001241:Aspirin