[The adequacy of a new method for assessing the vestibular protective effect of biologically active substances].
The effects of some neuropsychotropic agents on changes in pain sensitivity in albino male rats under the action of complex accelerations were investigated. It was found that administration of drugs with the antimotion-sickness activity--scopolamine, phenamine, phenibut prevented the development of analgesia with the opiate component, the use of low-effective and non-effective with respect to suppression of vestibulo-vegetative disturbances agents--diazepam, ephedrine, haloperidol failed to exert such an effect.
Karkishchenko
N N
NN
Dimitriadi
N A
NA
D000054:Acceleration / Q000009:adverse effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004361:Drug Tolerance; D008297:Male; D009041:Motion Sickness / Q000188:drug therapy; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D011619:Psychotropic Drugs
Izuchenie adekvatnosti novogo metoda otsenki vestibuloprotektornogo vliianiia biologicheski aktivnykh veshchestv.