[Secretion of tumor necrosis factor alpha (TNF-alpha) by peripheral blood monocytes in patients with multiple sclerosis and subacute sclerosis panencephalitis].
TNF alpha production by peripheral blood monocytes was studied in seventeen patients with a recent exacerbation of MS, thirteen with remission of MS and fourteen patients with SSPE. Monocytes from both MS groups spontaneously secreted high amounts of TNF alpha in vitro. Addition of lipopolisaccharide could not stimulate further synthesis of TNF alpha. In SSPE spontaneous and stimulated TNF alpha release did not differ from that in the control group. The observed changes in TNF alpha release in MS patients could play a role in the pathogenesis of the disease.
Piotrowska
K
K
Zakładu Genetyki, Instytutu Psychiatrii i Neurologii, Warszawie.
Korlak
J
J
Kruszewska
J
J
Iwińska
B
B
Członkowska
A
A
D002478:Cells, Cultured; D003470:Culture Media; D006801:Humans; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000097:blood*; D013268:Stimulation, Chemical; D013344:Subacute Sclerosing Panencephalitis / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D003470:Culture Media; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha
Wydzielanie czynnika nekrotycznego guza alpha (tumor necrosis factor alpha TNF-alpha) przez monocyty krwi obwodowej pacjentów ze stwardnieniem rozsianym i podostrym stwardniajacym zapaleniem mózgu.