title: Induction of 2'-5' A synthetase activity and interferon in humans by bacteria used in dairy products.
abstract: The production of interferon by fasted human subjects in response to lactic bacteria Lactobacillus bulgaricus and Streptococcus thermophilus was evaluated in vivo and in vitro. The 2'-5' A synthetase activity of blood mononuclear cells was used to estimate interferon production following a single ingestion of 10(11) bacteria in yoghurt or sterile milk (controls). The level of the 2'-5' A synthetase of the yoghurt fed subjects was 83% (p = 0.002) higher than that of the milk fed controls 24 hours after ingestion. The baseline value remained unchanged in the control group. Blood mononuclear cells from a second group of subjects, were cultured with lactic bacteria for 48 hours, their cell-free supernatants contained gamma interferon. These results suggest that a transient production of interferon can be induced in healthy subjects by the lactic bacteria used in food processing.
authors.affiliation: Unité de Recherches sur la Nutrition et l'Alimentation, Hôpital Bichat, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Solis Pereyra
authors.forename: D
authors.initials: D
authors.lastname: Lemonnier
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000096:biosynthesis*; D000328:Adult; D000818:Animals; D003611:Dairy Products / Q000382:microbiology*; D004790:Enzyme Induction; D005260:Female; D005285:Fermentation; D005786:Gene Expression Regulation; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D007778:Lactobacillus / Q000276:immunology* / Q000302:isolation & purification; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008297:Male; D008892:Milk / Q000382:microbiology; D013291:Streptococcus / Q000276:immunology* / Q000302:isolation & purification; D015014:Yogurt / Q000382:microbiology
chemical_list: D007371:Interferon-gamma; D015088:2',5'-Oligoadenylate Synthetase