[Aluminum deposition in the central nervous system tissues of patients with Parkinson's disease].
Aluminum (Al) concentration in the 26 anatomic central nervous system (CNS) regions, liver, kidney, spleen and heart of our patients with Parkinson's disease, and five neurologically normal controls was measured by a non-destructive neutron activation analysis (NAA), in order to clarify the implication of Al on pathogenesis of Parkinson's disease. Al concentration in substantia nigra, caudate nucleus and globus pallidus increased in patients with Parkinson's disease more than that in controls (p less than 0.05). There was a significant difference in Al concentration of gray matter and basal ganglia in Parkinson's disease, compared with those of controls (p less than 0.01). It is likely that high Al deposition in pathological foci responsible for Parkinson's disease might be implicated in the pathogenesis of Parkinson's disease.
Yasui
M
M
Division of Neurological Diseases, Wakayama Medical College.
Kihira
T
T
Ota
K
K
Mukoyama
M
M
Adachi
K
K
D000368:Aged; D000535:Aluminum / Q000032:analysis*; D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000737:chemistry; D005260:Female; D005917:Globus Pallidus / Q000737:chemistry; D006801:Humans; D008297:Male; D009501:Neutron Activation Analysis; D010300:Parkinson Disease / Q000378:metabolism*; D013378:Substantia Nigra / Q000737:chemistry
D000535:Aluminum