title: Temperature dependence of hypoxia-induced calcium accumulation in gerbil hippocampal slices.
abstract: Microfluorometry was used to investigate temperature dependence of hypoxia-induced intracellular calcium accumulation in gerbil hippocampal slice. When slices were superfused with hypoxic medium at 37 degrees C, 35 degrees C, 33 degrees C or 31 degrees C, latencies of acute increase of calcium accumulation, which was accompanied by a large negative shift of extracellular DC potentials, were delayed in a dose-dependent manner: mean latencies in field CA1 were 130 s, 182 s, 232 s and 277 s after hypoxia, respectively. This retardation in calcium accumulation may be involved in the mechanisms by which hypothermia diminishes ischemic injury.
authors.affiliation: Department of Physiology, School of Medicine, Ehime University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Mitani
authors.forename: F
authors.initials: F
authors.lastname: Kadoya
authors.forename: K
authors.initials: K
authors.lastname: Kataoka
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015687:Cell Hypoxia; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D007700:Kinetics; D008564:Membrane Potentials; D011712:Pyramidal Tracts / Q000378:metabolism / Q000502:physiology; D013696:Temperature
chemical_list: D002118:Calcium