title: [Philadelphia-positive ALL with rearrangement of the 1st intron of the BCR gene].
abstract: We have studied the haematologic, cytogenetic and molecular features in a patient with Ph positive ALL. The cytogenetic study showed the presence of a Ph chromosome since diagnosis. Molecular analysis showed rearrangement within the first intron of bcr gen instead of M-bcr as in CML. This an evidence of genic fusion between c-abl oncogene and bcr gene and also show the possibility of rearrangement outside M-bcr in these patients.
authors.affiliation: Dpto. Genética, Fundación Jiménez Díaz, Madrid.
authors.forename: A
authors.initials: A
authors.lastname: Valiente
authors.forename: A
authors.initials: A
authors.lastname: Escudero
authors.forename: J
authors.initials: J
authors.lastname: Benítez
mesh_terms: D000368:Aged; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007438:Introns; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051562:Proto-Oncogene Proteins c-bcr
chemical_list: D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr
vernacular_title: LAL Ph positivo con reordenamiento en el primer intron del gen BCR.