title: Efficacy of norfloxacin in bacterial conjunctivitis.
abstract: We investigated the efficacy and safety of norfloxacin 0.3% ophthalmic solution in 120 patients with bacterial conjunctivitis or blepharitis. Patients were selected for the study if they showed conjunctival hyperemia and at least three of the following criteria: a) symptoms of a surface ocular infection; b) a purulent discharge; c) crusting of the eyelids, and d) thickened, red lid margins. After taking a specimen for culture from the conjunctiva or skin-lash margin, the test drug was administered to the infected eye every two hours for one day, then 4 times daily for one week. Of the 120 patients who entered the study, 84.1% were cured. No serious adverse reactions occurred.
authors.affiliation: 2nd Department of Ophthalmology, Vienna, Austria.
authors.forename: V
authors.initials: V
authors.lastname: Huber-Spitzy
authors.forename: E
authors.initials: E
authors.lastname: Arocker-Mettinger
authors.forename: I
authors.initials: I
authors.lastname: Baumgartner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001762:Blepharitis / Q000188:drug therapy; D002648:Child; D003234:Conjunctivitis, Bacterial / Q000188:drug therapy*; D003315:Cornea / Q000382:microbiology; D004334:Drug Administration Schedule; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000627:therapeutic use*; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D009883:Ophthalmic Solutions; D009643:Norfloxacin