[The prevention of the development of the collagen-induced microembolic syndrome by decreasing the hydrodynamic resistance of the blood with special polymers under flow].
The search for antiaggregatory compounds is undertaken, as a rule, under in vitro conditions which do not reflect the dynamics of the real process. The present work deals with study of the peculiarities of the development of the collagen induced microembolic syndrome and the effect produced on it by hydrodynamic resistance reducing polymers under conditions modelling real circulation. The authors show the formation of a developed microembolic syndrome under the effect of collagen with accumulation of vasoconstrictors in the environment and increase of red cell hemolysis. Reduction of blood flow turbulence by the addition of solutions of neutral high-molecular linear polymers revealed the inhibiting effect of these polymers on the development of intracellular aggregate formation and concomitant red cell microhemolysis, which was attended by sharp reduction of thromboxane A2 production in the experiment. The authors show the significance of hemodynamic conditions in the development of the microembolic syndrome and the possibility of preventing it under conditions of modification of the blood flow with polymers, which may be of high prophylactic importance.
Konorova
I L
IL
Akopov
S E
SE
Gabrielian
E S
ES
Gannushkina
I V
IV
D001783:Blood Flow Velocity / Q000187:drug effects*; D002200:Capillary Resistance / Q000187:drug effects*; D003094:Collagen / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D005112:Extracorporeal Circulation / Q000295:instrumentation / Q000379:methods; D006801:Humans; D066298:In Vitro Techniques; D010477:Perfusion / Q000295:instrumentation / Q000379:methods; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011312:Pressure; D013577:Syndrome; D013923:Thromboembolism / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D013997:Time Factors
C061199:Polyox WSR-N 60; D011092:Polyethylene Glycols; D003094:Collagen
Predotvrashchenie razvitiia kollagenindutsirovannogo mikroémbolicheskogo sindroma posredstvom snizheniia gidrodinamicheskogo soprotivleniia krovi spetsial'nymi polimerami v usloviiakh potoka.