Ciprofloxacin versus gentamicin/clindamycin for postpartum endometritis.
An open, randomized, comparative study of intravenous ciprofloxacin versus gentamicin and clindamycin was performed on women with postpartum endometritis. Ciprofloxacin alone successfully eradicated the infections in 35 of 49 patients (71%), while the combination of gentamicin/clindamycin cured 41 of 48 (85%) (P = .15). The microbiology and antibiotic sensitivity of the endometrial isolates confirmed the poor activity of ciprofloxacin against anaerobic bacteria and less-than-optimal activity against Streptococcus faecalis. Ciprofloxacin, when used alone, may not be suitable for the treatment of postpartum endometritis.
Maccato
M L
ML
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030.
Faro
S
S
Martens
M G
MG
Hammill
H A
HA
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D004716:Endometritis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D011645:Puerperal Infection / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology
D005839:Gentamicins; D002981:Clindamycin; D002939:Ciprofloxacin