Antiulcerogenic effect of pentacaine, chlorpromazine and stobadine on ethanol- and indomethacin-induced stomach lesions in rats.
The aim was to compare the antiulcerogenic effect of pentacaine, chlorpromazine and stobadine on indomethacin- and ethanol-induced stomach lesions in rats. Pentacaine effectively inhibited the formation of ethanol lesions, but in the given dose and under the given experimental conditions it was ineffective against indomethacin-induced damage. Chlorpromazine and stobadine effectively inhibited indomethacin erosions, but did not affect ethanol lesions significantly. The similarity of the effect of chlorpromazine and stobadine as compared with pentacaine, in the two stomach injury models, allows the assumption that stobadine has properties typical for an indirectly acting antiulcerogenic substance. This newly discovered property of stobadine extends the possibilities of its utilization to a further set of indications.
Mirossay
L
L
Department of Pharmacology, Faculty of Medicine, Safárik University, Kosice.
Kohút
A
A
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D000431:Ethanol; D016166:Free Radical Scavengers; D007213:Indomethacin; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects*
D000897:Anti-Ulcer Agents; D002219:Carbamates; D002243:Carbolines; D016166:Free Radical Scavengers; D000431:Ethanol; C010618:pentacaine; D002746:Chlorpromazine; D007213:Indomethacin; C100106:dicarbine