[Effect of drugs inhibiting prostaglandin activity on the appearance of leukocytes in the tears after experimental injury to the corneal epithelium].
The investigations were carried out on 3 groups of rabbits in which the corneal epithelium was removed and into the conjunctival sac were instilled drugs inhibiting the activity of prostaglandins such as indomethacin solution or a 0.5 p.c. solution of ibuprofen. It was demonstrated that these drugs lead in the period of the first 8 hours to reduction of the number of leucocytes in tears from 2 to 20 times in comparison with the control group. The presented observation show that prostaglandin inhibitors may be a successful mean leading to decrease of number of leucocytes in tears after corneal injury.
Toczołowski
J
J
Kliniki Okulistycznej AM w Lublinie.
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects* / Q000276:immunology; D065306:Corneal Injuries; D004195:Disease Models, Animal; D004848:Epithelium / Q000293:injuries; D005260:Female; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology*; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007958:Leukocyte Count / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D008297:Male; D011448:Prostaglandin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013666:Tears / Q000166:cytology* / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D011448:Prostaglandin Antagonists; D007052:Ibuprofen; D007213:Indomethacin
Wpływ leków hamujqcych aktywność prostaglandyn na pojawianie sie leukocytów w łzach po doświadczalnym uszkodzeniu nabłonka rogówki.