[Suspected convulsive side-effect of mefloquine (Lariam)].
A 20 years old female patient with epileptic seizures (bilateral myoclonus and generalized tonic-clonic seizures (bilateral myoclonus and generalized tonic-clonic seizures) since the age of 13 was treated with valproic acid. Eight hours after 2 of 3 prophylactic antimalarial treatments with mefloquine generalized tonic-clonic seizures occurred. A causal relationship is suggested.
Besser
R
R
Neurologische Klinik, Universität Mainz.
Krämer
G
G
D000328:Adult; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D004831:Epilepsies, Myoclonic / Q000139:chemically induced* / Q000503:physiopathology; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008288:Malaria / Q000503:physiopathology / Q000517:prevention & control*; D015767:Mefloquine / Q000008:administration & dosage / Q000009:adverse effects*; D010634:Phenobarbital / Q000008:administration & dosage; D014635:Valproic Acid / Q000008:administration & dosage
D014635:Valproic Acid; D015767:Mefloquine; D010634:Phenobarbital
Verdacht auf anfallfördernde Wirkung von Mefloquin (Lariam).