The immunology of xenotransplantation.
The transplantation of organs between species (xenografting) has long been considered impracticable due to the immunological barriers allegedly induced by the antigenic disparity of distantly related species. This paper challenges the long held dogma's on the immunology of xenografting. We present evidence that T-cells are not necessarily involved in the rejection of organs transplanted between closely related species and that antibody is not necessarily involved in the rejection of grafts between distantly related species.
White
D J
DJ
Department of Surgery, University of Cambridge, Addenbrooke's Hospital, United Kingdom.
Van der Borgarde
J
J
Lim
S M
SM
D000818:Animals; D000941:Antigens / Q000276:immunology; D004195:Disease Models, Animal; D006085:Graft Survival / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology; D014183:Transplantation, Heterologous / Q000276:immunology*
D000941:Antigens; D007166:Immunosuppressive Agents