Pharmacological and toxicological studies on new Rh(I) organometallic complexes.
New rhodium(I) complexes, belonging to the general structure [Rh(CO)2 (L)], where dithiocarbamate and xanthate derivatives, were synthesized and assayed as cytostatic and antitumour agents in vitro against KB cells and in vivo against P388 leukaemia, Ehrlich ascites carcinoma, Sarcoma 180 ascites and ADJ/PC6A solid tumour. Assays against five trypanosoma strains were also performed. Among the new compounds the [Rh(CO)2 (DPA-dtc)] appeared to be active in all biological systems without showing evident nephrotoxicity.
Craciunescu
D G
DG
Department of Inorganic and Bioinorganic Chemistry, Faculty of Pharmacy, University of Madrid, Spain.
Scarcia
V
V
Furlani
A
A
Papaioannou
A
A
Parrondo Iglesias
E
E
Alonso
M P
MP
D005069:Evaluation Studies as Topic; D006801:Humans; D007668:Kidney / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D012238:Rhodium / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013859:Thiocarbamates / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D014407:Tumor Cells, Cultured
D009942:Organometallic Compounds; D013859:Thiocarbamates; C074271:dicarbonyldiphenylaminedithiocarbamate rhodium(I); D012238:Rhodium