title: Canine latissimus dorsi cardio-double myoplasty: acute feasibility study.
abstract: Cardio-double myoplasty was performed in eight mongrel dogs. Both latissimus dorsi muscles were dissected from the chest wall and wrapped around the heart. They were then stimulated using an R wave synchronous stimulator. Hemodynamic measurements were obtained, first with the stimulator off and then with stimulator activated. After measuring hemodynamic effects in a normal heart, acute heart failure was induced by the infusion of propranolol (5 mg/kg). Hemodynamic data were then obtained in the same fashion. In a normal heart state, cardio-double myoplasty increased the cardiac output 9.9% +/- 2.24 (p less than 0.005), the left ventricular pressure 18.7% +/- 3.53 (p less than 0.001), the pulmonary artery pressure 72.2% +/- 25.4 (p less than 0.01), and the stroke volume 13.4% +/- 5.73 (p less than 0.05). In a failing heart, the cardiac output increased 21.6% +/- 3.34 (p less than 0.005), the left ventricular pressure increased 20.8% +/- 3.34 (p less than  0.005), the pulmonary artery pressure increased 87.2% +/- 39.9 (p less than 0.05), and the stroke volume increased 46.9% +/- 22.9 (p less than 0.05). The left ventricular end-diastolic pressure decreased slightly and the central venous pressure did not change in either the normal state or during cardiac failure. Cardio-double myoplasty resulted in a significant circulatory augmentation particularly in the setting of cardiac failure.
authors.affiliation: Division of Cardiothoracic Surgery, Wayne State University, School of Medicine, Detroit, Michigan 48201.
authors.forename: H
authors.initials: H
authors.lastname: Niinami
authors.forename: A
authors.initials: A
authors.lastname: Pochettino
authors.forename: R
authors.initials: R
authors.lastname: Ruggiero
authors.forename: A
authors.initials: A
authors.lastname: Koroteyev
authors.forename: H
authors.initials: H
authors.lastname: Lu
authors.forename: E
authors.initials: E
authors.lastname: Hohenhaus
authors.forename: A D
authors.initials: AD
authors.lastname: Spanta
authors.forename: R L
authors.initials: RL
authors.lastname: Hammond
authors.forename: L W
authors.initials: LW
authors.lastname: Stephenson
mesh_terms: D000818:Animals; D001243:Assisted Circulation; D001415:Back; D004285:Dogs; D004558:Electric Stimulation / Q000379:methods; D005240:Feasibility Studies; D006333:Heart Failure / Q000503:physiopathology / Q000601:surgery*; D006439:Hemodynamics; D009119:Muscle Contraction; D009132:Muscles / Q000502:physiology / Q000601:surgery; D013524:Surgical Flaps / Q000379:methods*