[Effect of thiophosphamide on the early period of gametogenesis in CBA, 101/H and AKR mice].
On the 12th day of pregnancy CBA, 101/H and AKR mice were given thiophosphamide in a dose of 5 mg/kg bw, and were sacrificed on the 19th day of pregnancy. The action of thiophosphamide on embryonal ovaries and testes was studied by assaying for the population of oocytes and relative number of the different stages of meiotic prophase I; index of the degeneration germ cells; for the population of prospermatogonies and their degeneration; morphometric study of nucleus of nucleolus of prospermatogonies. A significant decrease of germ cells was found in male and female embryos on the 19th day of pregnancy after thiophosphamide injection. Interspecific differences were found as regards the number of germ cells and their proportion in health as well as in response to a single antenatal injection of thiophosphamide.
Khil'kevich
L V
LV
Kurilo
L F
LF
Korogodina
Iu V
IuV
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D005260:Female; D005718:Gametogenesis / Q000187:drug effects*; D005854:Germ Cells / Q000187:drug effects; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D010053:Ovary / Q000187:drug effects / Q000196:embryology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012727:Sex Characteristics; D013045:Species Specificity; D013737:Testis / Q000187:drug effects / Q000196:embryology; D013852:Thiotepa / Q000633:toxicity*
D013852:Thiotepa
Effekt tiofosfamida na ranniĭ period gametogeneza u mysheĭ liniĭ CBA, 101/H i AKR.