Experimental evidence on pineal renin-angiotensin system as activator of serotonin and melatonin synthesis.
Intravenous infusion of angiotensin II in quasi-physiological concentrations for two hours induced an increase in serotonin and N-acetyltransferase content of pineal gland in dogs and rats. Results are interpreted with regard to the concept of the activating role of the pineal renin-angiotensin system on the serotonin and melatonin biosynthesis.
Haulică
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Department of Physiology, University of Medicine and Pharmacy Iaşi.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000187:drug effects / Q000378:metabolism; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D008550:Melatonin / Q000096:biosynthesis*; D010870:Pineal Gland / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000096:biosynthesis*
D000804:Angiotensin II; D012701:Serotonin; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin