The effect of eicosapentaenoic acid consumption on human neutrophil chemiluminescence.
The effect of eicosapentaenoic acid (EPA) on the inflammatory potential of neutrophils was investigated by supplementing the diets of 12 subjects with 2.16 g of EPA or 12 g of olive oil per day for 4 weeks in a double blind crossover study. Neutrophil function as assessed by luminol enhanced chemiluminescence responses to platelet-activating factor (PAF) and formyl-methionyl-leucyl-phenylalanine (FMLP) was significantly reduced after EPA but not after olive oil consumption in the subjects who consumed EPA first. In contrast, EPA had no significant effect on neutrophil chemiluminescence in the subjects who consumed olive oil first. Dietary supplementation with EPA inhibits neutrophil responses to inflammatory mediators such as PAF while other fatty acids appear to modify the effects of EPA.
Thompson
P J
PJ
Department of Medicine, University of Western Australia, Nedlands.
Misso
N L
NL
Passarelli
M
M
Phillips
M J
MJ
D000328:Adult; D004041:Dietary Fats; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007700:Kinetics; D008163:Luminescent Measurements; D008297:Male; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D000069463:Olive Oil; D010938:Plant Oils / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000494:pharmacology*; D013997:Time Factors
D004041:Dietary Fats; D000069463:Olive Oil; D010938:Plant Oils; D010972:Platelet Activating Factor; D009240:N-Formylmethionine Leucyl-Phenylalanine; D015118:Eicosapentaenoic Acid