Hippocampal and body temperature changes in rats during delayed matching-to-sample performance in a cold environment.
In order to study the effects of temperature changes induced by cold stress on working memory, telemetry thermistor probes were implanted into the hippocampal region of the brain and into the peritoneal cavity of rats. Temperatures in these regions were monitored while rats performed on a delayed matching-to-sample (DMTS) task at ambient temperatures of 23 degrees C and 2 degrees C. Matching accuracy was significantly decreased during exposure to 2 degrees C, indicating a marked impairment of short-term or working memory. Temperature in the hippocampus increased 2 degrees C during exposure to 23 degrees C, but only 1 degrees C when the environmental temperature was 2 degrees C. Body temperature showed a similar but less pronounced pattern in that cold exposure attenuated the increase in temperature observed when animals performed the DMTS task. These results suggest that cold-induced impairment of working memory may be associated with subtle temperature changes in the brain.
Ahlers
S T
ST
Behavioral Neuroscience Division, Naval Medical Research Institute, Bethesda, MD 20889-5055.
Thomas
J R
JR
Berkey
D L
DL
D000818:Animals; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology*; D001931:Brain Mapping; D004193:Discrimination Learning / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D051381:Rats; D011930:Reaction Time / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*