Urinary elimination of molybdenum by healthy subjects as determined by inductively coupled plasma mass spectrometry.
The concentration of molybdenum was measured by inductively coupled plasma mass spectrometry (ICPMS) in the urines of two groups of healthy people living in two areas of France, Brest and Paris, about 500 km away. The concentration of Mo in the 24-hour urines of 10 healthy subjects from the Brest region was 25 +/- 10 micrograms/l, 38 +/- 20 micrograms/24 h and 21 +/- 9 micrograms/g creatinine. The concentration of Mo in the morning urines of 23 healthy men of the Paris region was 41 +/- 34 micrograms/l and 21 +/- 15 micrograms/g creatinine. Thus the mean elimination of Mo per gram of creatinine was the same in the two groups (21 +/- 9 and 21 +/- 15). Since the three main isotopes of Mo m/z = 95, 96 and 98, corresponding to an abundance percentage of 16, 17 and 24.5, respectively, were simultaneously analyzed in each sample and led to similar results, the ICPMS method seems reliable.
Allain
P
P
Laboratoire de Pharmacologie, Centre Hospitalier Universitaire, Angers, France.
Berre
S
S
Prémel-Cabic
A
A
Mauras
Y
Y
Cledes
A
A
Cournot
A
A
D000328:Adult; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008982:Molybdenum / Q000652:urine*
D008982:Molybdenum