title: Tissue distribution of 14C-diflubenzuron in Atlantic salmon (Salmo salar).
abstract: Diflubenzuron is a potent inhibitor of chitin synthesis, with potential use against salmon lice infestations. The absorption, distribution and elimination of the substance in Atlantic salmon was examined after a single, oral dose of 75 mg/kg bodyweight. The kinetic properties were studied by whole-body autoradiography, liquid scintillation counting and thin layer chromatography, using a 14C-labelled isotope of the substance. The drug was poorly absorbed from the intestine, but reached a concentration of more than 4 micrograms/g in the mucus layer of the skin 2 days after administration. If maintained for several days, this concentration is probably sufficient to control all moulting stages of sea lice in Atlantic salmon. The main route of excretion was via the bile.
authors.affiliation: Department of Pharmacology and Toxicology, Norwegian College of Veterinary Medicine, Oslo.
authors.forename: T E
authors.initials: TE
authors.lastname: Horsberg
authors.forename: T
authors.initials: T
authors.lastname: Høy
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism; D004132:Diflubenzuron / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012474:Salmon / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D004132:Diflubenzuron