C7*N is a hypomorphic allele of the human complement c7 M/N protein polymorphism.
Two complement C7 protein polymorphisms exist. One is determined by isoelectric focussing whereas the other is determined by the reaction pattern of a monoclonal C7-allospecific antibody in an ELISA assay. C7 concentrations quantitated by an ELISA based on polyclonal C7-specific IgG and data from functional haemolytic assays were compared with the allotypes of both C7 protein polymorphisms. Testing a randomly selected Japanese population revealed that not only C7*3 but also C7*N is a hypomorphic allele. However, no significant disease association of C7*N or C7*M was found in studies of hospitalized patients.
Würzner
R
R
Molecular Immunopathology Unit, Medical Research Council Centre, Cambridge, UK.
Tokunaga
K
K
Nitze
R
R
Götze
O
O
Lachmann
P J
PJ
D044466:Asian People / Q000235:genetics; D003184:Complement C7 / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007525:Isoelectric Focusing; D007564:Japan; D010641:Phenotype; D011110:Polymorphism, Genetic
D003184:Complement C7