Pharmacokinetic profiles of prazepam and 14C-prazepam in rat.
Pharmacokinetics of Prazepam and 14C-Prazepam were studied in rat. Prazepam was measured in blood and plasma by a gas-liquid chromatography assay with an electron capture detector. Its major metabolite, Desmethyldiazepam, was also determined in blood in the same way. Total radioactivity was measured in plasma by scintillation spectrometry. Pharmacokinetic analysis were carried out by two ways; according to compartmental pharmacokinetic models and by statistic moments.
Dios-Vieitez
M C
MC
Departamento de Farmacia y Technologia Farmaceutica, Facultad de Farmacia, Universidad de Navarra, Spain.
Renedo
M J
MJ
Fos
D
D
D000818:Animals; D002849:Chromatography, Gas; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D003708:Nordazepam / Q000097:blood; D011222:Prazepam / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D003708:Nordazepam; D011222:Prazepam