[Synthesis and anticonvulsant activity of 3-carbamoyl-4-aryl-isoquinolin-1(2H)-ones].
The syntheses of nineteen 3-carbamoyl-4-aryl-isoquinoline-1(2H)-ones are described. The compounds show anticonvulsant activity in maximal electroshock test (i.p. administration). A representative substance is 3-carbamoyl-2-isopropyl-4-(4-chlorophenyl)-isoquinoline-1(2H)-one, ED50 = 2.1 x 10(-4) mol/kg. This agent shows 20% of the activity of phenytoin (ED50 = 0.44 x 10(-4) mol/kg).
Unverferth
K
K
Sektion Biowissenschaften, Universität Leipzig.
Dörre
R
R
Körner
B
B
Scheibe
H
H
Morgenstern
E
E
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology; D004597:Electroshock; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice
D000927:Anticonvulsants; D002219:Carbamates; D007546:Isoquinolines
Synthese und antikonvulsive Aktivität von 3-Carbamoyl-4-aryl-isochinolin-1(2H)-onen.