Natural killer cells in meningiomas.
A monoclonal antibody against the surface marker IOT-10 of natural killer (NK) cells was used to investigate the presence of these cells in a series of twenty intracranial meningiomas. In all of these tumours, IOT-10 positive NK cells were found in small numbers, mainly distributed among the tumor cells. Two recurrent tumors showed a relatively high number of immunostained cells. The data obtained in the present study suggest that a NK-cell-mediated immunological response can occur in meningioma tissue.
Vaquero
J
J
Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Coca
S
S
Pontón
P
P
Oya
S
S
Arias
A
A
D000328:Adult; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D001932:Brain Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007694:Killer Cells, Natural; D016246:Lymphocytes, Tumor-Infiltrating; D008297:Male; D008579:Meningioma / Q000276:immunology*; D008875:Middle Aged; D009367:Neoplasm Staging; D014057:Tomography, X-Ray Computed
D000911:Antibodies, Monoclonal; D015415:Biomarkers