[Granulocyte metabolic activity in chronic nonspecific lung diseases].
Biochemiluminescent (BCL) investigation of oxidative metabolism in patients suffering from chronic nonspecific lung diseases (CNLD) has shown activation of granulocyte metabolism measured by zymosan-dependent luminol-amplified chemiluminescence and the intensification of lipid peroxidation estimated by spontaneous serum BCL. At the same time H2O2-induced BCL was decreased, attesting to the abatement of antioxidative activity. The revealed imbalance of oxidative and antioxidative processes may be the pathogenic factor in CNLD development.
Men'shchikova
E B
EB
Zenkov
N K
NK
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000097:blood; D001991:Bronchitis / Q000097:blood; D005260:Female; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008163:Luminescent Measurements; D008173:Lung Diseases, Obstructive / Q000097:blood*; D008297:Male; D008875:Middle Aged
Metabolicheskaia aktivnost' granulotsitov pri khronicheskikh nespetsificheskikh zabolevaniiakh legkikh.