title: Proton NMR imaging of cerebral blood flow using H2(17)O.
abstract: Cerebral blood flow was quantitatively mapped by monitoring the cerebral washout of H2(17)O using rapid, single-shot proton NMR imaging. H2(17)O acts as a freely diffusible contrast agent for proton imaging via its scalar-coupled term, enhancing T2 relaxation. Measured values for CBF ranged from 29 to 106 ml/min/100 g over a range of arterial pCO2 between 23 and 81 Torr.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Charlestown 02129.
authors.forename: K K
authors.initials: KK
authors.lastname: Kwong
authors.forename: A L
authors.initials: AL
authors.lastname: Hopkins
authors.forename: J W
authors.initials: JW
authors.lastname: Belliveau
authors.forename: D A
authors.initials: DA
authors.lastname: Chesler
authors.forename: L M
authors.initials: LM
authors.lastname: Porkka
authors.forename: R C
authors.initials: RC
authors.lastname: McKinstry
authors.forename: D A
authors.initials: DA
authors.lastname: Finelli
authors.forename: G J
authors.initials: GJ
authors.lastname: Hunter
authors.forename: J B
authors.initials: JB
authors.lastname: Moore
authors.forename: R G
authors.initials: RG
authors.lastname: Barr
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation; D004285:Dogs; D009682:Magnetic Resonance Spectroscopy; D010103:Oxygen Isotopes; D014867:Water
chemical_list: D010103:Oxygen Isotopes; D014867:Water