title: A comparison of the effect of synthetic and naturally occurring surfactants on the solubility and absorption of clofazimine (B 663).
abstract: All simple micellar systems investigated, containing both naturally occurring and synthetic surfactants, enhanced the solubility of clofazimine. The incorporation of fatty acid to form mixed micelles, brought about a further enhancement in drug solubility in the case of naturally occurring surfactants, in contrast, with synthetic surfactants this enhancement decreased. The most effective absorption promoter was a synthetic surfactant: fatty acid mixed micellar system. The results indicate an optimum surfactant: fatty acid ratio at which the solubility and membrane effects of the surfactant system are balanced.
authors.affiliation: University of Dublin, Dept. of Pharmaceutics, School of Pharmacy, Trinity College, Ireland.
authors.forename: C M
authors.initials: CM
authors.lastname: O'Driscoll
authors.forename: J R
authors.initials: JR
authors.lastname: O'Reilly
authors.forename: O I
authors.initials: OI
authors.lastname: Corrigan
mesh_terms: D000042:Absorption / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002991:Clofazimine / Q000737:chemistry*; D008823:Micelles; D010539:Permeability; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D008823:Micelles; D013501:Surface-Active Agents; D002991:Clofazimine