[Binding of (3)-imipramine by platelets from spontaneously hypertensive, normotensive, and Wistar rats and their behavior in stressful situations].
Spontaneously hypertensive rats (SHR), when submitted to stress remained active during both avoidance (water escape task test) and nonavoidance (forced swimming test) stress-situations. Wistar rats responded to a depression of active behaviour in forced swimming test and difficulty at resolving of complicated problem in water escape task test. did not differ in the affinity but the number of binding sites of 3H-imipramine was greater in SHR. SHR rats had a smaller number of binding sites that Wistar ones.
Bondarenko
N A
NA
Department of Pharmacology and Toxicology, University of Helsinki, Finland.
Liliekvist
R
R
Paasonen
M K
MK
Val'dman
A V
AV
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001665:Binding Sites; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D007099:Imipramine / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013312:Stress, Physiological
D007099:Imipramine
Sviazyvanie (3)-imipramina trombotsitami spontanno gipertenzivnykh, normotenzivnykh i krys linii vistar i ikh povendenie v stress-situatsiiakh.