[Adaptation of the body to stressors prevents the cardiotoxic effect of rifampicin but not polymyxin B].
It was established on isolated rat hearts that adaptation of the organism to stress exposure effectively limits toxic effect of chronic rifampicin administration (7 mg/kg/day for 8 days) and does not affect the depression of contractile function induced by chronic polymyxin B administration (0.12 mg/kg/day for 8 days). Possible mechanism of the effect of organism's adaptation to stress on the resistance of heart to antibiotics is under discussion.
Malyshev
I Iu
IIu
Meerson
F Z
FZ
D000222:Adaptation, Physiological; D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000201:enzymology; D010477:Perfusion; D011112:Polymyxin B / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D012293:Rifampin / Q000494:pharmacology*; D013312:Stress, Physiological / Q000503:physiopathology*
D011493:Protein Kinase C; D012321:DNA-Directed RNA Polymerases; D011112:Polymyxin B; D012293:Rifampin
Adaptatsiia organizma k stressornym vozdeĭstviiam preduprezhdaet kardiotoksicheskiĭ éffekt rifampicin, no ne polimiksina B.