A case of xanthinuria: a study on the metabolism of pyrazinamide and allopurinol.
A 74-year-old female was diagnosed as having xanthinuria by measurement of the uric acid level in plasma, purine bases in urine and activity of xanthine oxidase in the duodenal mucosa. The determination of the urinary excretion of purine bases in her family demonstrated a slightly increased urinary excretion of oxypurines in her younger brother, suggesting that he was a heterozygote. The pyrazinamide-loading test and allopurinol-loading test demonstrated that she could neither metabolize pyrazinoic acid into 5-hydroxypyrazinoic acid nor allopurinol into oxypurinol, although there was a slight metabolizing of prazinamide into 5-hydroxypyrazinamide. This suggested that she belonged to the subgroup which can neither metabolize pyrazinamide into 5-hydroxypyrazinamide, pyrazinoic acid into 5-hydroxypyrazinoic acid nor allopurinol into oxypurinol.
Yamamoto
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Kario
K
K
Suda
M
M
Moriwaki
Y
Y
Takahashi
S
S
Higashino
K
K
D000368:Aged; D000493:Allopurinol / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000652:urine; D010375:Pedigree; D011718:Pyrazinamide / Q000378:metabolism; D014527:Uric Acid / Q000652:urine; D019820:Xanthine; D014969:Xanthine Oxidase / Q000172:deficiency; D014970:Xanthines / Q000652:urine*
D007042:Hypoxanthines; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D011718:Pyrazinamide; D019271:Hypoxanthine; D000493:Allopurinol; D003404:Creatinine; D014969:Xanthine Oxidase