Dysfibrinogenemia and thrombosis.
A thrombotic tendency (venous or arterial) has been reported in some cases of dysfibrinogenemia. We report here the mechanism by which these thrombosis may occur. It may be related either to a defective clot lysis due to a poor reactivity toward fibrinolytic enzymes or to a defective thrombin binding capacity of the abnormal clot. Acquired fibrin clot structure anomalies may also be responsible for a defective thrombolysis.
Soria
J
J
GEFFACS, Laboratoire Sainte Marie, Hôtel Dieu, Paris, France.
Soria
C
C
Collet
J P
JP
Mirishahi
M
M
Lu
H
H
Caen
J P
JP
D005337:Fibrin / Q000378:metabolism; D015241:Fibrinogens, Abnormal / Q000378:metabolism*; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D011485:Protein Binding; D013917:Thrombin / Q000378:metabolism; D013927:Thrombosis / Q000097:blood*
D015241:Fibrinogens, Abnormal; D005337:Fibrin; D013917:Thrombin