Antimicrobial activity of three investigational oral cephalosporins (BK-218, cefdinir, and RU29246) against Legionella.
Three new, orally administered cephalosporins (BK-218, cefdinir, RU29246) were tested against 13 representative strains of Legionella. Cefdinir was most active [50% minimum inhibitory concentration (MIC50), 1 micrograms/ml], a potency comparable to the reference drug cefixime and eightfold less active than erythromycin. BK-218 was the least active cephalosporin (MIC50, 8 micrograms/ml) or 100-fold less potent than rifampin. These investigational cephems appear poorly suited by activity assays for Legionellosis therapy.
Jones
R N
RN
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
Erwin
M E
ME
Barrett
M S
MS
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000077525:Cefdinir; D002511:Cephalosporins / Q000494:pharmacology*; D006801:Humans; D007875:Legionella / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C063639:BK 218; C073743:RU 29246; D000077525:Cefdinir