title: Histological grading and DNA content as predictors of distant metastases in squamous cell carcinoma of the uterine cervix.
abstract: Squamous cell carcinoma of the uterine cervix with distant metastases can be treated by adjuvant chemotherapy. The at-risk patients are those with histologically proven metastases, the presence of tumour in paracervical tissue and parametrium, evidence of vascular invasion, a great depth of invasion, or poor tumour differentiation. Our studies lead us to believe that differentiation and DNA content are also important criteria.
authors.affiliation: Research Institute of Clinical and Experimental Oncology, Brno, Czechoslovakia.
authors.forename: M
authors.initials: M
authors.lastname: Anton
authors.forename: R
authors.initials: R
authors.lastname: Nenutil
authors.forename: J
authors.initials: J
authors.lastname: Zaloudík
mesh_terms: D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery
chemical_list: D004273:DNA, Neoplasm