Increased glucocorticoid receptors in diphenylhydantoin induced human gingival overgrowth.
A pilot study on the glucocorticoid receptors in normal and pathological condition of human gingiva was carried out for a better perception of glucocorticoid action in gingiva. Gingival cytosol prepared from normal and diphenylhydantoin induced overgrowth was incubated with [3H]dexamethasone with or without cold competitor. Results obtained show a single class of receptor in both the conditions with no difference in binding specificity. Contrary to this, B-max was found to be significantly increased in the overgrown tissue sample compared to normal. The increase in glucocorticoid receptors in the gingival pathology is discussed.
Suresh
R
R
Department of Biochemistry, Central Leather Research Institute, Adyar, Madras, India.
Dhar
S C
SC
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005881:Gingiva / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000494:pharmacology*; D011965:Receptors, Glucocorticoid / Q000187:drug effects* / Q000378:metabolism
D011965:Receptors, Glucocorticoid; D010672:Phenytoin