title: Glomerular pathology in surviving pigs experimentally infected with African swine fever virus.
abstract: Twelve miniature pigs were inoculated with an attenuated African swine fever virus to study glomerular involvement in surviving pigs. In acute phase, kidneys were severely affected and displayed a glomerular capillary thrombosis with fibrin deposition in vascular lumen, detected by immunofluorescence. Fibrin-positive deposits were progressively cleared between one to three months after infection in surviving pigs. The histological picture in kidneys of surviving pigs, up to one post-infection year, showed a focal and segmental glomerulonephritis with hyalinosis, and IgM and C3 deposition was detected by immunofluorescence. Its pathogeny as an evolutive stage of acute glomerular injury is pointed out.
authors.affiliation: National Institute of Agrarian Research, Department of Animal Sanity, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Martín-Fernández
authors.forename: A
authors.initials: A
authors.lastname: Igual
authors.forename: A
authors.initials: A
authors.lastname: Rueda
authors.forename: J M
authors.initials: JM
authors.lastname: Sánchez-Vizcaíno
authors.forename: C
authors.initials: C
authors.lastname: Alonso-Martí
mesh_terms: D000357:African Swine Fever / Q000150:complications* / Q000473:pathology; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D005337:Fibrin / Q000032:analysis; D005921:Glomerulonephritis / Q000209:etiology*; D007075:Immunoglobulin M / Q000032:analysis; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000737:chemistry / Q000473:pathology*; D013552:Swine; D014766:Viremia / Q000473:pathology
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex; D003176:Complement C3; D007075:Immunoglobulin M; D005337:Fibrin