The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus.
A 400 nucleotide cDNA clone encoding the depressant insect toxin of the scorpion Buthotus judaicus (BjIT2), was isolated. DNA sequence analysis suggests that the toxin is a processed product of a precursor composed of: (1) a 21 amino acid residue signal peptide; (2) a 61 amino acid region of the mature toxin; and (3) an additional Arg-Lys-Lys tail at the carboxy terminus prior to a termination codon. Comparison between the precursor polypeptides of BjIT2 and another depressant insect toxin derived from the scorpion Leiurus quinquestriatus hebraeus (LqhIT2) shows similarities in their hydropathic profiles.
Zilberberg
N
N
Department of Botany, Tel-Aviv University, Ramat-Aviv, Israel.
Zlotkin
E
E
Gurevitz
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019476:Insect Proteins; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry / Q000235:genetics*; D010957:Plasmids / Q000235:genetics; D012604:Scorpion Venoms / Q000737:chemistry / Q000235:genetics*
D019476:Insect Proteins; D009498:Neurotoxins; D012604:Scorpion Venoms; C073271:Bjit2 toxin