title: [Clinical study of intramuscular imipenem/cilastatin sodium in the field of obstetrics and gynecology].
abstract: The efficacy and the safety of intramuscular imipenem/cilastatin sodium (IPM/CS) were evaluated in 22 patients with obstetric and gynecologic infections. 0.5 g/0.5 g of IPM/CS was suspended in a lidocaine solution and administered in the gluteal muscle twice a day for 3-7 days. Nineteen patients with intrauterine infections were evaluable for the clinical efficacy and 22 for the safety. 1. Clinical efficacies were excellent in 6 patients, good in 11 and poor in 2, and the efficacy rate was 89.5%. Thirteen out of 14 patients who had not responded to treatments with other previously administered antibiotics showed excellent or good responses to IPM/CS. 2. Causative bacteria were eradicated in 5 patients, decreased in 2, unchanged in 3 and replaced in 3, with an eradication rate of 61.5%. 3. Among 22 patients treated with IPM/CS, an eruption and general itching were observed in 1 patient, but no abnormal laboratory test values were observed.
authors.affiliation: Department of Obstetrics and Gynecology, Juntendo University, School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Matsuda
authors.forename: K
authors.initials: K
authors.lastname: Oh
authors.forename: M
authors.initials: M
authors.lastname: Tateno
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: K
authors.initials: K
authors.lastname: Hirabayashi
authors.forename: E
authors.initials: E
authors.lastname: Okada
authors.forename: F
authors.initials: F
authors.lastname: Doko
authors.forename: J
authors.initials: J
authors.lastname: Kawai
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D015377:Cilastatin / Q000008:administration & dosage* / Q000627:therapeutic use; D000077728:Cilastatin, Imipenem Drug Combination; D004338:Drug Combinations; D005260:Female; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage* / Q000627:therapeutic use; D007273:Injections, Intramuscular; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D014591:Uterine Diseases / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination