Determination of cefsulodin, cefmenoxime, and cefadroxil as residues on surfaces.
Cefsulodin, cefmenoxime, and cefadroxil are degraded instantaneously in aqueous sodium hypochlorite, sodium hypochlorite-detergent, or alkaline detergent solutions. These alkaline solutions are used to clean surfaces that have been exposed to the cephalosporins. The cleaned surfaces are monitored for residual drug levels (microgram) using a wet swab-dry swab technique. After extraction from the swabs, the content of the respective cephalosporin is determined in the solution by high-performance liquid chromatography. The limit of detection for each of the compounds is 0.1 microgram/ml. Recoveries from nonporous surfaces ranged from 56 to 102%.
Gorski
R J
RJ
Analytical Research Department, Abbott Laboratories, North Chicago, Illinois 60064-4000.
Plasz
A C
AC
Elrod
L
L
Yoder
J
J
White
L B
LB
D002434:Cefadroxil / Q000032:analysis*; D015281:Cefmenoxime / Q000032:analysis*; D002441:Cefsulodin / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003902:Detergents; D004350:Drug Residues / Q000032:analysis; D011786:Quality Control
D003902:Detergents; D002434:Cefadroxil; D015281:Cefmenoxime; D002441:Cefsulodin