[Probable location of synaptic inputs, evoking generation of long-term IPSP in pyramidal neurons: model studies].
A region of possible location of potassium-conducting synapses responsible for generation of "slow", or "long-term" IPSPs has been determined in computer experiments with the use of neuroscience-oriented software program CRONA on the basis of data of measurement of reversal potential of such IPSPs under natural experiments. Such geometrical parameters as dimensions of neuronal dendritic branches and intracellular potassium concentration have been studied for their effect on determination of the above-mentioned region using the results of natural experimental studies of interaction of long-term IPSPs with polarizing currents. It is shown that synaptic inputs under investigation have non-somatic location and the region of their location on apical dendrites is between 110 and 460 microns from the soma.
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Korogod
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Ianovskiĭ
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D003198:Computer Simulation; D003712:Dendrites / Q000648:ultrastructure; D005071:Evoked Potentials / Q000502:physiology; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D012984:Software; D013569:Synapses / Q000502:physiology*; D013997:Time Factors
Veroiatnaia lokalizatsiia sinapticheskikh vkhodov, vyzyvaiushchikh generatsiiu dlitel'nykh TPSP v piramidnykh neĭronakh: model'nye issledovaniia.