title: Extracellular volume in preterm infants: influence of gestational age and colloids.
abstract: We assessed the effect of fresh frozen plasma (FFP) on extracellular volume (ECV) during the first few days of life in two groups of preterm infants, group 1 (gestational age less than 30 weeks) and group 2 (gestational age 30-34 weeks). The infants were randomly assigned to one of two treatment groups, one receiving FFP, the other not; group 1 infants receiving no treatment (n = 8) and group 1 infants receiving FFP (n = 11), and group 2 infants receiving no treatment (n = 9) and group 2 receiving FFP (n = 10). FFP was given at a dose of 10 ml/kg daily during a two-hour period for the first three days of life. ECV was measured on day 1 before FFP was given and on day 4 by the distribution of bromide. There was a significant correlation between birth weight and initial ECV (r = 0.85, P less than 0.001). In group 1 ECV was significantly higher than in group 2 (P less than 0.02). In group 1 receiving no treatment mean weight loss and mean decrease in ECV were equal (84 g/kg and 78 ml/kg, respectively), but no correlation between the two parameters could be found (r = 0.68, P = 0.06). In the other study groups, mean weight loss was higher than mean decrease in ECV, with no correlation between weight loss and change in ECV.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pediatrics, University of Turku, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Ekblad
authors.forename: P
authors.initials: P
authors.lastname: Kero
authors.forename: S G
authors.initials: SG
authors.lastname: Shaffer
authors.forename: H
authors.initials: H
authors.lastname: Korvenranta
mesh_terms: D000704:Analysis of Variance; D016913:Blood Component Transfusion; D001792:Blood Platelets; D001835:Body Weight; D005110:Extracellular Space; D005440:Fluid Therapy; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D012044:Regression Analysis; D012964:Sodium / Q000097:blood; D014882:Water-Electrolyte Balance
chemical_list: D012964:Sodium