[2-Aryl substituted benzo-anellated 5-ring-heterocycles as potential agents for the cardiovascular system. 2. 1,3-Benzimidazoles].
In the course of investigations on structure-activity relationships of fostedil-and sulmazole-analogously fused 5-membered heterocycles, 1,3-benzimidazoles were obtained by simple cyclisation. In vitro experiments on isolated organs demonstrate markedly positive inotropic effects of some derivatives, whereas others exert both relaxing activity on smooth musculature in vitro and antihypertensive effects in vivo. Moreover they exhibit fungicide properties in vitro.
Rose
U
U
Institut für Pharmazie, Johannes-Gutenberg-Universität Mainz.
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000138:chemical synthesis*; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D001562:Benzimidazoles; D002317:Cardiovascular Agents
2-Arylsubstituierte benzoanellierte 5-ring-heterocyclen als potentielle Wirkstoffe im kardiovaskulären System. 2. Mitteilung: 1,3-Benzimidazole.