The toxic effects of combined exposure to toluene and m-xylene in animals. II. Blood toluene and m-xylene during single and combined exposure in rats.
The influence of combined exposure to m-xylene and toluene vapours at a concentration of 100 + 100 ppm on blood m-xylene concentration in rats was investigated. Within 6-7 hours of coexposure to m-xylene and toluene a significant increase in blood m-xylene concentration, in comparison to single exposure to m-xylene at concentration of 100 ppm, was observed. Study results may suggest that, reported earlier, the more than additive toxic effects of combined exposure to m-xylene and toluene in animals may result from its metabolic interaction.
Korsak
Z
Z
Department of Toxicology Evaluation, Institute of Occupational Medicine, Lodz, Poland.
Sokal
J A
JA
Swiercz
R
R
D000818:Animals; D004357:Drug Synergism; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D014050:Toluene / Q000493:pharmacokinetics / Q000633:toxicity*; D014992:Xylenes / Q000493:pharmacokinetics / Q000633:toxicity*
D014992:Xylenes; D014050:Toluene; C031285:3-xylene