title: [Prognostic value of local recurrence after conservative treatment of cancers of the breast ].
abstract: To determine the prognostic significance of local relapse after conservative treatment of an invasive carcinoma of the breast, we analysed the results obtained in a series of 512 patients. All patients had a lumpectomy with axillary dissection followed by irradiation. Adjuvant medical treatment was administered to 168 patients. The actuarial 5 years and 10 years overall survival rates were respectively 92.5% and 79.7%. Local relapses occurred in 35 patients (6.8%). The actuarial 5 and 10 years local control rates were respectively 91.2% and 83.6%. In these patients, risk of metastasis was significantly increased as compared with patients without a local relapse. Recurrence in the breast within 2 years of initial treatment several affected the risk of metastasis occurring as compared to later relapses. We conclude that the occurrence of a breast relapse after successful local conservative treatment is a bad prognostic factor, predictive of a high risk for the development of distant metastases.
authors.affiliation: Département de Gynécologie-Obstétrique et Biologie de la Reproduction Humaine, Centre Hospitalier Universitaire de Tours, Hôpital Bretonneau.
authors.forename: A
authors.initials: A
authors.lastname: Lemseffer
authors.forename: G
authors.initials: G
authors.lastname: Body
authors.forename: B
authors.initials: B
authors.lastname: Chauvet
authors.forename: A
authors.initials: A
authors.lastname: Fignon
authors.forename: F
authors.initials: F
authors.lastname: Fetissof
authors.forename: G
authors.initials: G
authors.lastname: Calais
authors.forename: A
authors.initials: A
authors.lastname: Reynaud-Bougnoux
authors.forename: O
authors.initials: O
authors.lastname: Le Floch
authors.forename: J
authors.initials: J
authors.lastname: Lansac
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008197:Lymph Node Excision / Q000592:standards*; D015412:Mastectomy, Segmental / Q000592:standards*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D009367:Neoplasm Staging; D011159:Population Surveillance; D011379:Prognosis; D011878:Radiotherapy / Q000592:standards*; D012307:Risk Factors; D015996:Survival Rate
vernacular_title: Valeur pronostique de la récidive locale après traitement conservateur des cancers du sein.