Hepatitis B surface and e antigen seropositivity in mothers and cord blood at Port Moresby General Hospital: implications for a control program.
Analysis of 100 unselected paired maternal and cord blood samples showed 11 mothers to be HBsAg positive and 6 of these to be also HBeAg positive. 5 cord blood samples were HBsAg positive and 3 were HBeAg positive. Assuming a protective efficacy rate of 75%, the present plasma-derived hepatitis B virus vaccine control program is likely to prevent the perinatal acquisition of the hepatitis B virus carrier state in 27 per 1000 children. The addition of immunoglobulin prophylaxis would be likely to reduce this by another 5 per 1000, but its use does not appear practicable at the present time.
Sapuri
M
M
Department of Obstetrics and Gynaecology, University of Papua New Guinea.
Babona
D M
DM
Klufio
C A
CA
Vince
J D
JD
D000328:Adult; D002353:Carrier State / Q000453:epidemiology / Q000276:immunology; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006513:Hepatitis B e Antigens / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D010219:Papua New Guinea / Q000453:epidemiology; D016036:Seroepidemiologic Studies
D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens