[Clinical description of three cases of cerebral cryptococcosis in patients with AIDS treated with fluconazole].
The authors have evaluated the efficacy of Fluconazole (400 mg/iv/die for three days and after 200 mg/iv/die for 18 days) in three AIDS and SNC Cryptococcal infection patients. Two patients have shown healing of meningeal syndrome and negative isolation after 21 days of therapy; one patient, however, died because of Cytomegalovirus pneumonia. It is of note that early spinal puncture in AIDS patients with neurological symptoms enables an early diagnosis and immediate therapy. Fluconazole treatment has been well tolerated and immediately effective to resolve two of the cases observed; the oral prophylaxis with 100 mg/die of Fluconazole after 6 months has been effective to prevent the relapses of the disease.
Izzo
E
E
III Divisione, Presidio Ospedaliero, D. Cotugno Specializzato in Malattie Infettive, USL 41, Regione Campania.
Piccinino
R
R
Caruso
I
I
Bisogno
A
A
Pesce
G
G
Liberti
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001927:Brain Diseases / Q000188:drug therapy*; D003453:Cryptococcosis / Q000150:complications / Q000188:drug therapy*; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008297:Male
D015725:Fluconazole
Descrizione clinica di tre casi di criptococcosi cerebrale in pazienti con AIDS trattati con Fluconazolo.