title: [Comparative studies of toothpastes and toothpaste ingredients in biological systems: 1. Can various toothpastes be differentiated by relative biological effectiveness in cell culture studies?].
abstract: The cytotoxicity of 15 commercial toothpastes was examined in human epithelial cell cultures. The following parameters were evaluated: protein concentration, DNA-synthesis, cell morphology and autoradiography. In comparison to the control cell culture, one toothpaste had no influence on the cell growth at all. The other pastes caused a more or less strong growth inhibition, which also depended on the concentration of the toothpaste suspension. The presented investigations showed that the cytotoxicity tests applied to toothpastes yielded a good validity.
authors.affiliation: Zentrum Zahn-, Mund- und Kieferheilkunde, Universität Göttingen.
authors.forename: B
authors.initials: B
authors.lastname: Gerckens
authors.forename: G
authors.initials: G
authors.lastname: Eisinger
authors.forename: P
authors.initials: P
authors.lastname: Kaden
authors.forename: W
authors.initials: W
authors.lastname: Krüger
mesh_terms: D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D006801:Humans; D014100:Toothpastes / Q000633:toxicity*
chemical_list: D014100:Toothpastes; D004247:DNA
vernacular_title: Vergleichende Untersuchungen von Zahnpasten und Zahnpasten-Bestandteilen in biologischen Systemen: 1. Lassen sich verschiedene Zahnpasten im Zellkulturversuch bezüglich ihrer biologischen Wirkung differenzieren?