Inhibition of HIV replication by baicalin and S. baicalensis extracts in H9 cell culture.
Crude extracts of Scutellia baicalensis and a particular low molecular weight substance known as Baicalin were shown to inhibit HIV antigen expression in H9 cell culture, with 50% inhibitory doses of 0.6 microgram/ml and 3.3 micrograms/ml, respectively. They also inhibited P24 antigen production in H9 cells, with IC50's of 1.94 and 4.74 micrograms/ml, respectively. Cytoxicity was tested in H9 and HUT78 cells: Both exhibited relatively low levels of cytoxicity. These results indicated that S. baicalensis and Baicalin strongly inhibit HIV replication in cell culture.
Zhang
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Institute of Medical Biotechnology, CAMS, Beijing.
Tang
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X
Chen
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H
D000890:Anti-Infective Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000187:drug effects; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D016655:HIV Core Protein p24 / Q000096:biosynthesis / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects*
D000890:Anti-Infective Agents; D000956:Antigens, Viral; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D016655:HIV Core Protein p24; C038044:baicalin