Macular choroidal occlusion in dysplasminogenemia.
The authors describe a family with dysplasminogenemia. This diagnosis was based on a lowered ratio of functional plasminogen activity to immunologic plasminogen antigen level, associated with fundus abnormalities. The proband is a 31-year-old woman with Graves disease who had choroidal occlusive lesions of the macula in both eyes. The results of the laboratory examination indicated that the patient was a homozygote for dysplasminogenemia. Similar examinations of the patient's parents and siblings showed their plasminogen levels to be 50% below normal. The thrombotic tendency in this disorder appeared to be responsible for the pathogenesis of the macular choroidal occlusion.
Yamaguchi
K
K
Department of Ophthalmology, School of Medicine, Tohoku University, Sendai, Japan.
Abe
S
S
Shiono
T
T
Kimizuka
Y
Y
Hara
S
S
Tamai
M
M
Sugai
K
K
Mori
K
K
D000328:Adult; D002829:Choroid / Q000098:blood supply*; D003251:Constriction, Pathologic / Q000209:etiology; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008266:Macula Lutea / Q000098:blood supply*; D010958:Plasminogen / Q000172:deficiency*
D010958:Plasminogen