[Placental histogenesis and the cardiotoxic effect in rat progeny under the influence of the synthetic pyrethroid Decis].
A study is presented of the placenta histogenesis and development of cardiotoxic effect in rat progeny under the effect of the synthetic pyrethroid decis. The drug was introduced to pregnant animals perorally in 1/20 and 1/100 LD50 doses during the critical periods of neonatal development. Morphological disorders were revealed as well as a reduction of enzymatic activity (OP, SDG) in the placenta and ultrastructural and histochemical disorders of these enzymes in the myocardium of the progeny at different periods of ontogenesis. The revealed changes evidence the capacity of the pyrethroid decis to penetrate through the placental barrier and produce a cardiolesioning effect on the progeny.
Badaeva
L N
LN
Nedorenko
N I
NI
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000187:drug effects*; D007306:Insecticides / Q000633:toxicity*; D007928:Lethal Dose 50; D009206:Myocardium / Q000473:pathology; D009570:Nitriles; D010929:Placentation / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin
Gistogenez platsenty i kardiotoksicheskiĭ éffekt u potomstva krys pod vliianiem sinteticheskogo piretroida detsis.