Study on the metabolic fate of catena-(S)-[mu-N alpha-(3-aminopropionyl)histidinato(2-)-N1,N2,O:N tau]-zinc]. 3rd communication: transfer into fetus and milk in rats.
Studies on the transfer into the fetus and the milk were performed after administration of 14C-Z-103 and 65Zn-Z-103 (catena-(S)-[mu-[N alpha-(3-aminopropionyl)histidinato(2-)-N1,N2,O:N tau]- zinc], CAS 107667-60-7) to rats. After oral administration of 14C-Z-103 to pregnant rats, the transfer of radioactivity to the fetus was studied by means of whole body autoradiography (ARG) and measurement of radioactivity in the fetus. The concentration of radioactivity in the fetus was approximately the same as those in the blood and the placenta of the maternal animal. The transfer of radioactivity into the milk was demonstrated after administration of 14C-Z-103 to lactating rats. Radioactivity in the fetus and milk are considered to be due to metabolites of L-carnosine of Z-103, such as amino acid or protein. The distribution of radioactivity in the fetus was also observed after administration of 65Zn-Z-103 to pregnant rats. However, after administration of non-radioactive Z-103 to pregnant rats, the zinc level in the fetus was found to be almost the same level as that in the fetus of the untreated rats. The transfer of radioactivity to the milk was studied after administration of 65Zn-Z-103 to the lactating rats, and it was seen that the concentration of radioactive zinc in the milk was much lower than the endogenous level of zinc in the milk at any of the time points investigated.(ABSTRACT TRUNCATED AT 250 WORDS)
Toyama
S
S
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan.
Furuta
S
S
Miwa
M
M
Suzuki
M
M
Sano
H
H
Matsuda
K
K
D000818:Animals; D002336:Carnosine / Q000031:analogs & derivatives*; D004151:Dipeptides / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D008892:Milk / Q000378:metabolism*; D009942:Organometallic Compounds / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013054:Spectrophotometry, Atomic; D017967:Zinc Compounds; D015037:Zinc Radioisotopes
D004151:Dipeptides; D009942:Organometallic Compounds; D017967:Zinc Compounds; D015037:Zinc Radioisotopes; C061957:polaprezinc; D002336:Carnosine