[The effect of isoprenaline on the aggregation and adhesive properties of circulating rat neutrophils].
It is well known that isoprenaline (1-3-4-dihydroxy-phenyl-isopropyl-aminoethanol) (IP) induce necrosis in myocardium of laboratory animals, which is similar to pathomorphological development of clinical myocardial infarction. This process is accompanied by peripheral blood leukocytes. The IP-inductor effects on arachidonate-dependent aggregation and endothelial adhesion of peripheral blood neutrophils (PN) were studied in this paper. The enhancement of PN aggregational properties within 2-4 hours after intravenous IP-injection to rats was demonstrated. Using the method of vital microscopy it was shown that intravenous IP-injection to rats or IP-application on rat mesentery lead to an increase of leukocyte's marginal pool on the endothelium of mesenteric venules. However, it was noted that the change of cell functional properties is not due to the direct influence of IP on PN. The pathogenetic mechanisms of IP-induced cardiomyopathy in rats were discussed.
Naumov
O G
OG
Department of Physics, Sofia, Bulgaria.
Klebanov
G I
GI
Zaĭtsev
K T
KT
Banin
V V
VV
Borisova
L V
LV
Ribarov
S
S
Peneva
V
V
Vladimirov
Iu A
IuA
D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects*; D002449:Cell Aggregation / Q000187:drug effects*; D004730:Endothelium, Vascular / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects*; D051381:Rats
D016718:Arachidonic Acid; D007545:Isoproterenol
Vliianie izoprenalina na agregatsionnye i adgezivnye svoĭstva tsirkuliruiushchikh neĭtrofilov krys.t