title: Analgosedation-enhanced baroreflex sensitivity in acute local myocardial ischaemia.
abstract: In acute local myocardial ischaemia produced in mongrel dogs, the sensitivity of baroreflex decreased as electrical instability (vulnerability) of cardiac ventricles increased. Simultaneous administration of a benzodiazepine and a powerful analgesic (analgosedation) augmented both baroreflex sensitivity and ventricular fibrillation threshold. Modulation of neurovegetative activation of the heart by drugs in the early stage of ischaemia holds promise as a potential technique of sudden coronary death prevention.
authors.affiliation: Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
authors.forename: M
authors.initials: M
authors.lastname: Vrána
authors.forename: Z
authors.initials: Z
authors.lastname: Fejfar
authors.forename: L
authors.initials: L
authors.lastname: Hess
authors.forename: Z
authors.initials: Z
authors.lastname: Blazek
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects; D005283:Fentanyl / Q000494:pharmacology*; D008874:Midazolam / Q000494:pharmacology*; D011311:Pressoreceptors / Q000187:drug effects* / Q000502:physiology; D012018:Reflex / Q000187:drug effects* / Q000502:physiology; D014693:Ventricular Fibrillation / Q000503:physiopathology
chemical_list: D008874:Midazolam; D005283:Fentanyl