title: Autoantibody against liver cell membrane and killer cell activity in chronic liver diseases.
abstract: The aim of our present study was to examine the ADCC reaction against liver cell in various chronic liver diseases on the basis of indirect evidence. Forty-nine liver patients and one hundred and twenty-three healthy controls were examined. Anti-LSP autoantibody was determined on rat liver membrane by using the indirect immunofluorescent method. On the other hand, Killer-cell activity against human erythrocyte target cells was established in the lymphocytes of peripheral blood. Anti-LSP autoantibodies were demonstrated in seven patients and were associated with the high Killer-cell activity in six cases. Specific ADCC reaction to liver cell membrane can be assumed if anti-LSP autoantibody presence is topped with increased Killer-cell activity.
authors.affiliation: 2nd Department of Medicine, Róbert Károly Hospital, Budapest, Hungary.
authors.forename: R
authors.initials: R
authors.lastname: Schnabel
authors.forename: L
authors.initials: L
authors.lastname: Dalmi
authors.forename: S
authors.initials: S
authors.lastname: Sipka
authors.forename: M
authors.initials: M
authors.lastname: Bokor
authors.forename: G
authors.initials: G
authors.lastname: Malatinszky
authors.forename: T
authors.initials: T
authors.lastname: Garam
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity; D001323:Autoantibodies / Q000032:analysis*; D002462:Cell Membrane / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008074:Lipoproteins / Q000276:immunology; D008099:Liver / Q000276:immunology*; D008107:Liver Diseases / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D008074:Lipoproteins