title: A case of progressive systemic sclerosis (PSS) with silent thyroiditis and anti-bovine thyrotropin antibodies.
abstract: We have examined a patient with progressive systemic sclerosis (PSS) who had increased serum T3 (235 ng/dl) and T4 (13.2 micrograms/dl) and low 24-h thyroidal 123I-uptake (1.2%). A diagnosis of silent thyroiditis was made on the basis of the clinical course and laboratory and histopathologic findings. Simultaneous measurement of serum anti-thyrotropin receptor antibody (TRAb) showed a negative value (-49.0%) which suggested the presence of anti-TSH antibody. Further examination by immune precipitation with 125I-bovine TSH (bTSH) and also with 125I-human TSH (hTSH) revealed the presence of anti-bTSH antibody but not anti-hTSH antibody in his serum gamma-globulin. The significance of the association of PSS, silent thyroiditis, and anti-bTSH in one individual is discussed.
authors.affiliation: Third Department of Internal Medicine, Gifu University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Fuwa
authors.forename: K
authors.initials: K
authors.lastname: Chimori
authors.forename: N
authors.initials: N
authors.lastname: Yamakita
authors.forename: S
authors.initials: S
authors.lastname: Sakata
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood*; D002417:Cattle; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011233:Precipitin Tests; D012595:Scleroderma, Systemic / Q000150:complications / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000276:immunology*; D013972:Thyrotropin / Q000276:immunology*
chemical_list: D000906:Antibodies; D007457:Iodine Radioisotopes; D013972:Thyrotropin