Tail-tremor induced by exposure to cigarette smoke in rats.
Tremors appearing only in the tail (tail-tremor) induced by cigarette smoke and subcutaneous nicotine were investigated using a smoking machine and Wistar rats. Daily exposure (twice a day) to smokes of two commercial cigarettes (Mild-Seven Select for the first 7 days and Long-Peace for the next 6 days) caused the tail-tremor to appear even if it was slight. A single subcutaneous nicotine (0.5 mg/kg) administration to rats exposed to the cigarette smokes for 13 days markedly caused the tail-tremor. On the other hand, daily subcutaneous injection of nicotine (0.5 mg/kg/day) also caused the tail-tremor to appear beginning on the 4th day and the incidence of tremor increased to 100% by the 12th day. These results indicate that tail-tremor can be caused not only by daily subcutaneous administration of nicotine but also by daily exposure to cigarette smoke.
Gomita
Y
Y
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Suemaru
K
K
Furuno
K
K
Araki
Y
Y
D000818:Animals; D008297:Male; D009538:Nicotine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013623:Tail; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D014202:Tremor / Q000139:chemically induced*
D014028:Tobacco Smoke Pollution; D009538:Nicotine