[The effect of the acetanilide herbicide Acetochlor on the cardiovascular system of white rats].
A study is performed on the long-term effect of the chloracetanilide herbicide "Acetochlor" in doses 21.0; 10.6: 5.5 and 2.6 mg/kg-1 in conditions of 6-month oral application and 2-month rehabilitation period on the metabolite processes and the balance of the connective-tissue components in the myocardium and aorta of male white rats. A complex of biochemical and histological methods are performed (activity of succinate dehidrogenase, lactate dehydrogenase, glucose-6-phosphate dehydrogenase, adenosin triphosphatase, cytochrome oxidase, fructoso-1,6-diphosphatase, level of the thiol groups, soluble globular, elastine, collagen fractions, insoluble collagen and elastine, general and sulphated glucosamino glycanes). The dose 21.0 mg/kg-1 leads to blocking of the thyol groups, inactivation of succinate dehydrogenase, cytochrome oxidase, adenosin triphosphatase, fructose-1,6-diphosphatase, glucose-6-phosphate dehydrogenase, activation of lactate dehydrogenase, decrease of the soluble globular, elastine, and collagen fractions and increase of the glucoseaminoglycanes in the heart muscle and aorta. The changes established in the heart muscle at 10,6 mg/kg-1 certify for stronger sensitivity of the organ of the aorta wall. The presence of single changes in the examined indices, their complete dying out after the rehabilitation period and absence of structural changes in the myocardium and aorta permit the dose of 5.5 mg/kg-1 to be accepted as not effective in the conditions of chronic experiment concerning the cardiovascular system.
Antov
G
G
Buzidi
A
A
Shumkov
N
N
D000284:Administration, Oral; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects* / Q000201:enzymology; D003238:Connective Tissue / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004655:Emulsions; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051381:Rats; D013997:Time Factors; D014052:Toluidines / Q000008:administration & dosage / Q000633:toxicity*
D004655:Emulsions; D006540:Herbicides; D014052:Toluidines; C043377:acetochlor
Efekt na atsetanilidniia kherbitsid "Atsetokhlor" vŭrkhu sŭrdechno-sŭdovata sistema na beli plŭkhove.