[Cell biology and cosmetology].
Cellular biology can become the natural support of research in the field of cosmetics because it is able to provide alternative experimental models which can partially replace the massive use of laboratory animals. Cultures of human skin cells could be used in tests investigating irritation of the skin. We have developed an "in vitro" experimental model that allows to evaluate the damage caused by the free radicals to the fibroblasts in culture and to test the protective action of the lipoaminoacids. Experimenting on human cell cultures presents the advantage of eliminating the extrapolation between the different species, of allowing a determination of the biological action of a substance and of evaluating its dose/response effect. This does not mean that "in vitro" experimenting could completely replace experimenting on living animals, but the "in vitro" model can be introduced in the realisation of preliminary screenings.
Traniello
S
S
Institut de Chimie Biologique, Sciences et Techniques Cosmétiques, Université de Ferrare, Italie.
Cavalletti
T
T
D002478:Cells, Cultured; D003358:Cosmetics; D006801:Humans; D012867:Skin / Q000166:cytology*
D003358:Cosmetics
Biologie cellulaire et cosmétologie.