title: Nifedipine concentrations in maternal and umbilical serum, amniotic fluid, breast milk and urine of mothers and offspring.
abstract: Eleven hypertensive pregnant patients were treated with nifedipine orally 10 mg thrice daily. At steady state, nifedipine concentration, measured by the high-performance liquid chromatographic method, was 4.3 +/- 1.0 ng/ml (mean +/- s.e.m.) in maternal serum in the third trimester of pregnancy. During delivery, the parent drug levels in maternal and umbilical serum and in amniotic fluid were 12.4 +/- 4.0, 8.6 +/- 2.3 and 2.5 +/- 1.2 ng/ml, respectively. Small amounts of nifedipine were found also in urine of the neonates. In breast milk, the nifedipine concentration was 4.1 +/- 0.8 ng/ml on the third day after delivery. The antihypertensive effect of nifedipine did not correlate with the serum drug concentration. The outcome of pregnancy was favourable in all cases.
authors.affiliation: Department of Biomedical Sciences, University of Tampere, Finland.
authors.forename: A K
authors.initials: AK
authors.lastname: Manninen
authors.forename: A
authors.initials: A
authors.lastname: Juhakoski
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008431:Maternal-Fetal Exchange; D008895:Milk, Human / Q000737:chemistry*; D009543:Nifedipine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D011247:Pregnancy; D014018:Tissue Distribution
chemical_list: D009543:Nifedipine