[Effect of human neutrophil elastase, cathepsin--G. superoxide anion and endotoxin on the PGI2 production by cultured bovine pulmonary endothelial cells].
The effects of human neutrophil elastase (HNE), cathepsin-G, H2O2, xanthine oxidase-hypoxanthine derived superoxide anion and endotoxin on the PGI2 production by cultured bovine pulmonary endothelial cells were observed. The results showed that HNE, superoxide anion and H2O2 could decrease the PGI2 production by endothelial cells, and cathepsin-G had no effect on the production of PGI2. In our experiment, endotoxin could enhance PGI2 production. It was suggested that HNE, superoxide anion, and H2O2 may be involved in the pathogenesis of pulmonary hypertension.
Xing
J
J
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing.
D000818:Animals; D056649:Cathepsin G; D002403:Cathepsins / Q000494:pharmacology*; D002417:Cattle; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D004731:Endotoxins / Q000494:pharmacology*; D011464:Epoprostenol / Q000096:biosynthesis*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D019272:Leukocyte Elastase; D009504:Neutrophils / Q000378:metabolism; D010196:Pancreatic Elastase / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects / Q000378:metabolism; D012697:Serine Endopeptidases
D004731:Endotoxins; D006861:Hydrogen Peroxide; D011464:Epoprostenol; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase