title: [Adverse side effects of amalgam? An interdisciplinary study].
abstract: In an interdisciplinary study starting 2.5 years ago patients with various symptoms, which they associate with amalgam fillings, were examined. According to the first results of this study with 50 patients, the Hg-concentration in urine does correlate with the amount of amalgam fillings before and after taking DMPS (2,3-Dimercapto-1-propane-sulfonic-acid), but with a maximum of 66.4 micrograms Hg (24 h urine) the amounts of mobilization measured were significantly below toxicologically critical limits. Only in 3 patients did the individual immunological values (CD4/8 ratio, antinuclear antibodies) by far exceed standard values. In one case an allergy to amalgam is suspected. 40% of the patients showed a pathological psychiatric status (neurosis, depression, etc.). Another quarter had psychological problems like alcoholism or drug abuse. There is no reason at the moment to reject amalgam as filling material either because of the measured Hg-concentrations or because of any immunological or allergological findings.
authors.affiliation: Poliklinik für Zahnerhaltung und Parodontologie der Universität Erlangen-Nürnberg.
authors.forename: R
authors.initials: R
authors.lastname: Hickel
authors.forename: C
authors.initials: C
authors.lastname: Meier
authors.forename: R
authors.initials: R
authors.lastname: Schiele
authors.forename: W
authors.initials: W
authors.lastname: Raab
authors.forename: A
authors.initials: A
authors.lastname: Petschelt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000209:etiology; D016516:CD4-CD8 Ratio; D003723:Dental Amalgam / Q000009:adverse effects*; D004342:Drug Hypersensitivity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008628:Mercury / Q000652:urine*; D008630:Mercury Poisoning / Q000209:etiology / Q000276:immunology; D008875:Middle Aged
chemical_list: D003723:Dental Amalgam; D008628:Mercury
vernacular_title: Nebenwirkungen von Amalgam? Eine interdisziplinäre Studie.