title: [Immunocorrection in the combined treatment of patients with osteomyelitis developing following combined injuries to the maxillofacial and craniocerebral areas].
abstract: Twenty-one of the forty-two patients with osteomyelitis developing after a combined maxillofacial and craniocerebral injury were administered thymogen, an immunocorrective drug, as a component of combined therapy; immunologic indications for the prescription of such an agent were present in all these patients. Depressed T-cellular immunity was the principal disorder of the immunologic reactivity of this patient population; they also developed elevated counts of NK cells and increased interleukin synthesis by the macrophages, this reflecting a high activity of inflammation. Thymogen therapy was conducive to normalization of the immunologic and nonspecific reactivity and enhanced the treatment efficacy on the whole.
authors.forename: L A
authors.initials: LA
authors.lastname: Grigoriants
authors.forename: V P
authors.initials: VP
authors.lastname: Zuev
authors.forename: B R
authors.initials: BR
authors.lastname: Rakhmetov
authors.forename: V V
authors.initials: VV
authors.lastname: Eremeev
authors.forename: Z P
authors.initials: ZP
authors.lastname: Abramova
authors.forename: L L
authors.initials: LL
authors.lastname: Litvinova
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D001930:Brain Injuries / Q000150:complications / Q000276:immunology / Q000628:therapy*; D003131:Combined Modality Therapy; D004151:Dipeptides; D004341:Drug Evaluation; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D008446:Maxillofacial Injuries / Q000150:complications / Q000276:immunology / Q000628:therapy*; D009104:Multiple Trauma / Q000150:complications / Q000276:immunology / Q000628:therapy*; D010019:Osteomyelitis / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D010455:Peptides / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D004151:Dipeptides; D010455:Peptides; C060736:thymogen
vernacular_title: Immunokorrektsiia v kompleksnom lechenii bol'nykh s osteomielitom, razvivshimsia posle sochetannykh povrezhdeniĭ cheliustno-litsevoĭ i cherepno-mozgovoĭ oblasteĭ.