[Use of a new M-cholinolytic drug KG-62 for correction of the course of experimental stomach ulcer].
The preparation KG-62 related to iodomethylates of hydroxyalkyl phosphinic acids with muscarinolytic effect has been studied. The study provides data on the development of experimental gastric ulcer among rats after injections of the preparation. On the basis of morphologic, morphometric and biochemical data it has been stated that the preparation KG-62 in a 5 mg/kg dose has a more strong effect leading to quick gastric ulcer healing. It was supposed that not only suppressing action on hydrochloric acid and pepsinogen secretion lies in the mechanism of the effect but also the activation of physiologic regulation in intact tissue.
Denisov
A B
AB
Kulikov
L S
LS
Kardanov
N A
NA
Godovikov
N N
NN
Druzhinina
R A
RA
Pomerantseva
E N
EN
D000818:Animals; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
D010276:Parasympatholytics
Primenenie novogo M-kholinoliticheskogo preparata KG-62 dlia korrektsiitecheniia éksperimental'noĭ iazvy zheludka.