title: Sequence polymorphism of Amb a I and Amb a II, the major allergens in Ambrosia artemisiifolia (short ragweed).
abstract: Two of the major allergens in the pollen of short ragweed are Amb a I and Amb a II (formerly antigen E and antigen K, respectively). The genes for Amb a I and Amb a II have recently been cloned, and it was shown that Amb a I is a family of proteins with at least three distinct polymorphic family members. This study addresses the number of individual Amb a I and Amb a II family members, the polymorphism in each family member and the expression of these genes in ragweed plants from different geographical locations. This work led to the cloning and characterization of a fourth Amb a I family member, designated Amb a I.4.
authors.affiliation: ImmuLogic Pharmaceutical Corporation, Cambridge, Mass.
authors.forename: I J
authors.initials: IJ
authors.lastname: Griffith
authors.forename: J
authors.initials: J
authors.lastname: Pollock
authors.forename: D G
authors.initials: DG
authors.lastname: Klapper
authors.forename: B L
authors.initials: BL
authors.lastname: Rogers
authors.forename: A K
authors.initials: AK
authors.lastname: Nault
mesh_terms: D000485:Allergens / Q000737:chemistry* / Q000235:genetics*; D000595:Amino Acid Sequence; D052179:Antigens, Plant; D001483:Base Sequence; D008969:Molecular Sequence Data; D010936:Plant Extracts / Q000737:chemistry; D010940:Plant Proteins; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D000485:Allergens; C026967:Amb a I protein, Ambrosia artemisiifolia; D052179:Antigens, Plant; D010936:Plant Extracts; D010940:Plant Proteins; D012333:RNA, Messenger; C074244:Amb a II protein, Ambrosia artemisiifolia