Crosslinking with diacrylylpiperazine (PIP) reduces activation of complement by polyacrylamide microcapsules.
Activation of the complement system in vitro by a series of microcapsules based on polylysine, alginate or polyacrylamide was determined. Least activation was observed with microcapsules whose outer layer was composed of polyacrylamide. Activation was further reduced using diacrylylpiperazine instead of bisacrylamide as crosslinker.
Dupuy
B
B
INSERM U.306, Bordeaux, France.
Gin
H
H
Cadic
C
C
Baquey
A
A
Baquey
C
C
Ducassou
D
D
D000178:Acrylamides / Q000494:pharmacology*; D000180:Acrylic Resins / Q000494:pharmacology*; D002214:Capsules; D003167:Complement Activation / Q000187:drug effects*; D003176:Complement C3; D015932:Complement C3c; D003181:Complement C4; D003432:Cross-Linking Reagents; D008422:Materials Testing; D010879:Piperazines; D015054:Zymosan / Q000494:pharmacology; D000099166:Polyacrylamides
D000178:Acrylamides; D000180:Acrylic Resins; D002214:Capsules; D003176:Complement C3; D015932:Complement C3c; D003181:Complement C4; D003432:Cross-Linking Reagents; D010879:Piperazines; D015054:Zymosan; D000099166:Polyacrylamides; C074320:diacrylylpiperazine; C021221:N,N'-methylenebisacrylamide