Barbital N-glucoside is not detected as a urinary excretion product of barbital in humans.
A study was undertaken to determine if humans excreted barbital N-glucoside as a urinary metabolite following oral administration of barbital. A liquid chromatography method using gradient elution was developed for detecting and quantifying barbital N-glucoside and barbital in urine. Following a single oral dose of barbital to male caucasian and oriental subjects that had previously been shown to excrete amobarbital and phenobarbital N-glucosides, no barbital N-glucoside conjugate was observed in the urine. This result indicates that N-glucosylation of barbiturates is not a general pathway for the biodisposition of barbiturates in man.
Soine
W H
WH
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond 23298-0540.
Soine
P J
PJ
England
T M
TM
D000284:Administration, Oral; D000328:Adult; D001462:Barbital / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000652:urine; D002853:Chromatography, Liquid / Q000379:methods; D005960:Glucosides / Q000652:urine*; D006801:Humans; D008297:Male
D005960:Glucosides; C075630:barbital N-glucoside; D001462:Barbital