Proteolysis of defensive proteins in peritonitis exudate: pathobiochemical aspects and therapeutical approach.
Peritonitis exudate reveals strong proteolytic activity which is paralleled by deficient opsonic capacity and high concentrations of lysosomal proteinases (elastase and cathepsin B). Lysosomal serine and cysteine proteinases (elastase, cathepsins B, L) were shown to degrade immunoglobulin G(IgG) and seem to be at least partially responsible for the observed proteolytic inactivation of IgG in peritonitis exudates. Intraabdominal serum application seems to restore opsonic activity by substitution of opsonins and proteinase inhibitors.
Billing
A
A
Chirurgische Klinik und Poliklinik Ludwig-Maximilians-Universität München.
Fröhlich
D
D
Assfalg-Machleidt
I
I
Machleidt
W
W
Jochum
M
M
D001202:Ascitic Fluid / Q000276:immunology / Q000378:metabolism; D001769:Blood / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008247:Lysosomes / Q000276:immunology / Q000378:metabolism; D009895:Opsonin Proteins / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism*; D010538:Peritonitis / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D011506:Proteins / Q000378:metabolism*
D007074:Immunoglobulin G; D009895:Opsonin Proteins; D011506:Proteins; D010447:Peptide Hydrolases