title: Cardiac changes implicated in chronic heart block.
abstract: Fifteen cases of chronic heart block were studied. Eight of them could be designated as idiopathic or primary heart block; the others were associated with hypertension, diabetes and ischaemic heart disease, either singly or in various combinations. In six cases, the whole heart was available for histopathological study of the conduction system. In the other 9 cases, only a portion of the heart muscle was available for examination. A V nodal fibrosis extending upto the proximal bundle of His was seen in all the six whole heart autopsy materials. Fibrosis of the adjacent myocardium was seen in five cases. In three cases, conducting system fibrosis was associated with atherosclerotic (1 case) or diabetic changes (3 cases) of the intramural vessels. In the 9 partial autopsy studies, myocardial fibrosis was seen in two cases, diabetic microangiopathy in one and atherosclerotic changes in two including an old thrombus in one. Thus, diabetic microangiopathy was seen in total four cases. These changes may be responsible for the cardiomegaly and cardiac failure associated with conduction defects observed in diabetes. In the idiopathic group also, heart block could be considered as a significant facet of a primary myocardial degenerative process.
authors.affiliation: Department of Cardiology, Institute of Post-Graduate Medical Education and Research, Calcutta.
authors.forename: M
authors.initials: M
authors.lastname: Panja
authors.forename: A L
authors.initials: AL
authors.lastname: Dutta
authors.forename: A K
authors.initials: AK
authors.lastname: Kar
authors.forename: S
authors.initials: S
authors.lastname: Panja
authors.forename: M K
authors.initials: MK
authors.lastname: Chhetri
mesh_terms: D002908:Chronic Disease; D003327:Coronary Disease / Q000150:complications; D003925:Diabetic Angiopathies / Q000150:complications; D005260:Female; D006327:Heart Block / Q000209:etiology / Q000473:pathology*; D006329:Heart Conduction System / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*