[Clinical significance of drug resistance of tuberculosis mycobacteria and L-forms].
The clinical features of a tuberculous process were studied in 101 patients with active pulmonary tuberculosis among whom 76% of the patients lost their social adaptation. The patients were divided into 2 groups: group 1 comprising 61 (60.4%) subjects who excreted tuberculosis mycobacteria and L-forms and group 2 consisting of 40 (39.6%) who excreted only tuberculosis mycobacteria. The frequency and degree of drug resistance were more manifest in 63.8% of the patients of group 1 and in 40% of those of group 2 (p less than 0.01). Drug resistance to relatively new antituberculosis drugs (ethambutol and rifampicin) was found in 30% of the patients. Mixed bacillary population was found 2 times more frequently in patients with serious progressive forms of tuberculosis, which gives evidence to consider it as a prognostically unfavourable indicator.
Golanov
V S
VS
Bogdalova
V E
VE
Andreev
L P
LP
Losin
E I
EI
Ushakova
A G
AG
Meshcheriakov
V G
VG
Bondin
S V
SV
D000293:Adolescent; D000328:Adult; D004352:Drug Resistance, Microbial; D004977:Ethambutol / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007740:L Forms / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
D004977:Ethambutol; D012293:Rifampin
Klinicheskoe znachenie lekarstvenno-ustoĭchivykh mikobakteriĭ tuberkuleza i L-form.