title: Disturbance of thyroidal iodine metabolism in BB/W rat.
abstract: To investigate the thyroid function in Bio-Breeding Worcester (BB/W) rats, we have examined the iodine metabolism, serum TSH and thyroid hormone levels in 8- and 16-week-old BB/W and normal Wistar (W) rats. At 8 weeks of age, serum TSH levels were significantly higher in BB/W rats than in W rats, although there was no difference in the serum levels of free T3 and free T4. Furthermore, the thyroidal radioactive iodine incorporation at 48 h was significantly lower in BB/W rats, suggesting that they might have some defects in iodine organification. At 16 weeks of age, serum TSH levels were also significantly higher in BB/W rats than in W rats. Furthermore, serum TSH levels in 16-week-old BB/W rats were significantly higher than in 8-week-old BB/W rats. The thyroid weight was significantly greater in BB/W rats, probably due to the increased serum TSH. The thyroidal radioactive iodine uptake at 48 h and the iodine content in the thyroid homogenates were significantly lower in BB/W rats. These results suggest that BB/W rats have some defect in iodine metabolism resulting in impaired thyroid hormone synthesis.
authors.affiliation: Fourth Department of Internal Medicine, Saitama Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Miura
authors.forename: Y
authors.initials: Y
authors.lastname: Hara
authors.forename: M
authors.initials: M
authors.lastname: Iitaka
authors.forename: N
authors.initials: N
authors.lastname: Fukasawa
authors.forename: K
authors.initials: K
authors.lastname: Hase
authors.forename: M
authors.initials: M
authors.lastname: Urabe
authors.forename: Y
authors.initials: Y
authors.lastname: Sakatsume
authors.forename: M
authors.initials: M
authors.lastname: Yanagisawa
authors.forename: J
authors.initials: J
authors.lastname: Ishii
authors.forename: S
authors.initials: S
authors.lastname: Kawazu
mesh_terms: D000818:Animals; D007455:Iodine / Q000032:analysis / Q000378:metabolism* / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes; D009929:Organ Size; D011863:Radioimmunoassay; D051381:Rats; D011913:Rats, Inbred BB; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000737:chemistry / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine