[Synthesis of ST-1435 derivatives as contraceptive for lactating women].
Four new ST-1435 derivatives 4-7 were synthesized. Both 4 and 5 are mixture of Z- and E-isomers. 4 was separated into Z- and E-isomers by spinning TLC. Their binding ability to progesterone receptor was examined and found to be less than ST-1435.
Chen
G H
GH
Research Center for Drugs of Family Planning, China Pharmaceutical University, Nanjing.
Tu
S Z
SZ
Liao
Q J
QJ
D000818:Animals; D001942:Breast Feeding; D003271:Contraceptive Agents, Female / Q000138:chemical synthesis*; D005260:Female; D007774:Lactation; D009653:Norprogesterones / Q000138:chemical synthesis* / Q000378:metabolism; D051381:Rats; D011980:Receptors, Progesterone / Q000378:metabolism
D003271:Contraceptive Agents, Female; D009653:Norprogesterones; D011980:Receptors, Progesterone; C029167:ST 1435