Information of genome sequences and molecular basis of cancer.
This survey paper presents in a widely accessible form a thermodynamical approach to cancerogenesis and its relevance and utility for molecular biologists; it also suggests a possible definition of information contained in genome and of entropy leaps during cell transformation. A scenario concerning the amplification of an initial alteration in the genomic information during cancerogenesis is proposed, and its implication in our knowledge about spatial and temporal pattern of oncogenes and suppressor genes cooperation during cancerogenesis is discussed.
Marinescu
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I
Carcinogenesis and Molecular Genetics Dept. Institute of Oncology, Bucharest.
Voiculetz
N
N
D002471:Cell Transformation, Neoplastic / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics*; D013816:Thermodynamics