Immunogenicity and involvement in the host's effector mechanisms of the oncogene--induced transformation--associated cell surface antigens.
The clonal expression of oncogene-induced transformation-associated cell surface antigens (TAAs) of a WFB rat fetus fibroblast was analyzed by developing mAbs to TAAs. We identified four TAAs. Two out of four TAAs seemed to be involved in the cytotoxicity by NK cells. One is an hsp-like molecule. These TAAs may play an important role in the antitumor surveillance mechanism by the host immune system. By clarifying the molecular characteristics, it would be possible to apply the genes encoding these molecules in the immunotherapy of cancer.
Sato
N
N
Department of Pathology, Sapporo Medical College, Japan.
Cho
J M
JM
Takashima
T
T
Tsuboi
N
N
Nihei
T
T
Wada
Y
Y
Kikuchi
K
K
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D016867:Immunocompromised Host; D007694:Killer Cells, Natural / Q000276:immunology; D009857:Oncogenes / Q000235:genetics*
D000954:Antigens, Surface