In vitro activity of cefsulodin against multi-resistant isolates of Pseudomonas aeruginosa.
Clinical isolates of Pseudomonas aeruginosa from 245 patients with different infections were tested to determine their in vitro susceptibility to cefsulodin and other anti-pseudomonad antibiotics. Cefsulodin inhibited 90% of the isolates as compared with 89% by ceftazidime, 84% by piperacillin and 73% by ticarcillin. Of the three aminoglycosides used, gentamycin (60%) and netilmycin (77%) were less inhibitory. Amikacin was the most active, inhibiting 92% of the clinical isolates. Over 60% of the isolates resistant to ticarcillin and piperacillin were susceptible to cephalosporin and aminoglycosides used. Among cefsulodin-resistant isolates, ceftazidime was active against 67% and amikacin and netilmycin against 71% of isolates. Sixty percent of ceftazidime-resistant strains were susceptible to cefsulodin.
Qadri
S M
SM
King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
Billington
O
O
Cunha
B A
BA
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002441:Cefsulodin / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002441:Cefsulodin