Depressed urinary excretion of epidermal growth factor in psoriasis.
Epidermal growth factor (EGF) may have a modulatory role in renal growth and function. The aim of the present study was to evaluate whether urinary excretion of EGF is altered in psoriatic patients with or without arterial hypertension. The glomerular filtration rate was similar in psoriatics as compared with age- and sex-matched controls, whereas urinary EGF (microgram/g creatinine) was significantly reduced in psoriatics: normotensive subjects, 29.52 +/- 3.51 (psoriatics) versus 44.31 +/- 1.20 (controls, p less than 0.05); hypertensive subjects, 19.67 +/- 3.96 (psoriatics) versus 30.11 +/- 1.52 (controls, p less than 0.05). The urinary EGF excretion was lower in males than in females, save for hypertensive psoriatics. Urinary EGF correlated inversely with age and directly with urinary kallikrein excretion. Urinary kallikrein activity was reduced and microalbuminuria increased in hypertensive psoriatics. These alterations might suggest that initial deterioration of renal function is present in psoriasis.
Madeddu
P
P
Department of Medicine, University of Sassari, Italy.
Ena
P
P
Parpaglia
P P
PP
Patteri
G
G
Bacciu
S
S
Maioli
M
M
Glorioso
N
N
D004815:Epidermal Growth Factor / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000652:urine*; D007610:Kallikreins / Q000652:urine; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications / Q000503:physiopathology / Q000652:urine*; D012737:Sex Factors
D004815:Epidermal Growth Factor; D007610:Kallikreins