title: Investigation of the possible influence of the absorption of vinpocetine with concomitant application of magnesium-aluminium-hydroxide gel.
abstract: The concomitant application of magnesium-aluminium-hydroxide gel does not influence the absorption of vinpocetine (CAS 42971-09-5). The pharmacokinetics of vinpocetine under the influence of a concomitant application of magnesium-aluminium-hydroxide gel was investigated. 18 healthy male volunteers were included in the study. Vinpocetine was administered in the galenic form of a film-coated tablet in a dosage of 20 mg t.i.d. over 10 days. On days 5 and 6 of the study, blood samples were taken at 16 different moments over 24 h and analyzed as to their vinpocetine content. Starting with the 6th day of the study, the patients were administered in addition 1 sachet of an magnesium-aluminium-hydroxide gel 4 times a day. On day 9 of the trial, blood samples were taken again over 24 h. The parameters examined were AUC, Cmin, Cmax, tmax and Mean Residence Time. The results as to these parameters of day 5 were compared with those of day 9. As a further parameter, apovincaminic acid plasma levels were determined. There was no difference as to the vinpocetine amount absorbed with or without concomitant application of magnesium-aluminium-hydroxide gel. Apovincaminic acid plasma levels were lowered by approx. 11% when associated with the antacid.
authors.affiliation: Department of Pharmacokinetics, Thiemann Arzneimitte GmbH, Waltrop, Fed. Rep. of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Lohmann
authors.forename: P
authors.initials: P
authors.lastname: Grobara
authors.forename: E
authors.initials: E
authors.lastname: Dingler
mesh_terms: D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000863:Antacids / Q000494:pharmacology; D001682:Biological Availability; D002940:Circadian Rhythm; D004338:Drug Combinations; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008276:Magnesium Hydroxide / Q000494:pharmacology*; D008297:Male; D014748:Vinca Alkaloids / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000863:Antacids; D004338:Drug Combinations; D014748:Vinca Alkaloids; C032858:apovincaminic acid; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; C013983:vinpocetine; D000536:Aluminum Hydroxide; D008276:Magnesium Hydroxide