title: Genetic markers in refractory and susceptible malaria patients in village Bhanera, Distt. Ghaziabad, U.P.
abstract: Malaria 'susceptible' and 'refractory' subjects from village Bhanera in District Ghaziabad (Uttar Pradesh) were examined for various genetic markers, viz., ABO, haptoglobin, haemoglobin and glucose-6-phosphate dehydrogenase polymorphism. One hundred and nine susceptible and 36 refractory subjects were studied. No significant differences with respect to distribution patterns of the genetic markers were observed in the two groups except for AB blood group. In general, a high incidence of ahaptoglobinaemia was observed in this population and incidence increased with the increase in malaria attacks, suggesting that repeated malaria attacks cause ahaptoglobinaemia.
authors.affiliation: Malaria Research Centre, Delhi, India.
authors.forename: H
authors.initials: H
authors.lastname: Joshi
authors.forename: K
authors.initials: K
authors.lastname: Raghavendra
authors.forename: S K
authors.initials: SK
authors.lastname: Subbarao
authors.forename: M A
authors.initials: MA
authors.lastname: Ansari
authors.forename: R K
authors.initials: RK
authors.lastname: Razdan
authors.forename: C P
authors.initials: CP
authors.lastname: Batra
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D006242:Haptoglobins / Q000235:genetics; D006454:Hemoglobins / Q000235:genetics; D006801:Humans; D007194:India; D008288:Malaria / Q000235:genetics* / Q000276:immunology; D008297:Male
chemical_list: D000017:ABO Blood-Group System; D005819:Genetic Markers; D006242:Haptoglobins; D006454:Hemoglobins; D005954:Glucosephosphate Dehydrogenase