Excretion of urinary hydroxyproline in correlation with severity of induced osteomyelitis in rabbits.
Osteomyelitis was induced artificially by injecting Staphylococcus aureus culture in the tibiae of young rabbits. Weekly estimations of hydroxyproline in urine were done for six weeks. It was found that the osteomyelitic rabbits excreted more hydroxyproline (about 96%) two weeks after the infection in comparison to the control animals and it continued to be very high (about 138%) six weeks after the infection. The results indicate that urinary hydroxyproline reflects degradation of collagen fibers in the bone, and may be an indicator of the severity of the disease.
Abbas
H L
HL
Department of Zoology, Faculty of Sciences, University of Garyounis, Benghazi, Libya.
D000818:Animals; D001835:Body Weight; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D006439:Hemodynamics; D006909:Hydroxyproline / Q000652:urine*; D010019:Osteomyelitis / Q000382:microbiology / Q000652:urine*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000652:urine
D003094:Collagen; D006909:Hydroxyproline