title: [Possibilities of potentiating the antianginal action of nitrates by methionine in patients with stable effort angina pectoris].
abstract: When given in a single dose, methionine was studied for its effects on the efficacy of isosorbide dinitrate in 8 patients with coronary heart disease. The antianginal and anti-ischemic effects of the agents were evaluated by treadmill exercise testing that had been performed prior to and repeatedly (1, 2, 3, and 6 hours) following a single application of the drug. Methionine in a dose of 1 g failed to produce antianginal and anti-ischemic effects. The concomitant use of isosorbide dinitrate (10 mg) and methionine (1 g) showed significantly pronounced antianginal and anti-ischemic effect than that of isosorbide dinitrate alone. The methionine-induced increase in the effect of isosorbide dinitrate substantially differed in the patients. Thus, methionine is able to potentiate the antianginal and anti-ischemic effect of isosorbide dinitrate.
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Martsevich
authors.forename: M P
authors.initials: MP
authors.lastname: Kozyreva
authors.forename: V I
authors.initials: VI
authors.lastname: Metelitsa
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy*; D004357:Drug Synergism; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology* / Q000627:therapeutic use; D008715:Methionine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D008715:Methionine; D007548:Isosorbide Dinitrate
vernacular_title: Vozmozhnost' potentsirovaniia antianginal'nogo deĭstviia nitratov metioninom u bol'nykh so stabil'noĭ stenokardieĭ napriazheniia.