title: [The effects of sodium butyrate (NABT) on fibrillar centres and Ag-staining protein of nucleolus of human stomach glandular carcinoma (MGC-803) cells].
abstract: The changes in the ultrastructure of fibrillar centres, morphological type of nucleolus, and the content of Ag-nucleolus protein of Sodium Butyrate treated MGC-803 cells have been studied. It was found that the number of fibrillar centres and Ag-staining granules, content of Ag-staining protein of nucleolus were decreased, and nucleolar morphological type was changed from reticulated to ring-shaped in NaBT treated MGC-803 cells. These results indicate that NaBT regulate the proliferation and differentiation of cells by inhibiting rRNA synthesis and rDNA transcriptional activity.
authors.affiliation: Department of Cell Biology, Beijing Institute for Cancer Research.
authors.forename: G Z
authors.initials: GZ
authors.lastname: Lü
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.forename: L X
authors.initials: LX
authors.lastname: Zhou
authors.forename: Z X
authors.initials: ZX
authors.lastname: Lin
authors.forename: Y
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002466:Cell Nucleolus / Q000187:drug effects / Q000648:ultrastructure*; D006801:Humans; D016622:Silver Staining; D013274:Stomach Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured
chemical_list: D002087:Butyrates; D020148:Butyric Acid