Histology and lysosomal cytochemistry of the postsurgically inflamed dental pulp after topical application of steroids. I. Histological study.
The purpose of this study was to histologically investigate steroid effects on the dental pulp. Three steroid preparations, hydrocortisone, betamethasone and triamcinolone, were locally applied to the exposed pulp tissue in rat incisor after pulpectomy. After 24 h, the effects on the tissues were assessed by light microscopy. The results showed that topical application of corticosteroids as an intracanal medicament reduced inflammatory changes in the pulp as compared with controls. Furthermore, triamcinolone and betamethasone demonstrated more potent anti-inflammatory effects than did hydrocortisone.
Fachin
E V
EV
College of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Zaki
A E
AE
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001623:Betamethasone / Q000627:therapeutic use; D005938:Glucocorticoids; D006651:Histocytochemistry; D006854:Hydrocortisone; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D011670:Pulpectomy / Q000009:adverse effects; D011671:Pulpitis / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D014221:Triamcinolone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D014221:Triamcinolone; D001623:Betamethasone; D006854:Hydrocortisone