Anti-hepatitic activity of ginsenoside Ro.
Ginsenoside Ro, an oleanane-type saponin has been screened for activity in experimental models of acute and chronic hepatitis. Ginsenoside Ro (50 and 200 mg/kg, p.o.) inhibited the increase of serum glutamic oxaloacetic transaminase (s-GOT) and serum glutamic pyruvic transaminase (s-GPT) levels in D-galactosamine (GalN)- and carbon tetrachloride (CCl4)-induced acute hepatitic rats. Ginsenoside Ro inhibited the increase of connective tissue in the liver of CCl4-induced chronic hepatitic rats. Ginsenoside Ro showed a stronger inhibitory effect on the GalN-induced acute hepatitic model than those of the aglycone of ginsenoside Ro, oleanolic acid, or glycyrrhizic acid and its aglycone, glycyrrhetinic acid.
Matsuda
H
H
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
Samukawa
K
K
Kubo
M
M
D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D036145:Ginsenosides; D006520:Hepatitis, Animal / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins / Q000302:isolation & purification / Q000627:therapeutic use*
D036145:Ginsenosides; D012503:Saponins; C064378:ginsenoside Ro