Antibody response against autologous and heterologous isolates of Borrelia burgdorferi in four patients with Lyme neuroborreliosis.
Serum and cerebrospinal fluid (CSF) samples from four patients with Lyme neuroborreliosis were analyzed for IgM and IgG antibodies by an indirect enzyme immunoassay with the four patients' own CSF isolate of Borrelia burgdorferi and two tick isolates, strains STG152 and B31, as antigens. No major differences in the antibody response were found comparing autologous and heterologous strains as sonicate antigens, although a tendency towards a stronger response to the autologous isolates was noted in samples from two patients.
Karlsson
M
M
Department of Infectious Diseases, Danderyd Hospital, Sweden.
D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid*; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000097:blood / Q000134:cerebrospinal fluid; D008193:Lyme Disease / Q000134:cerebrospinal fluid / Q000276:immunology*; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000276:immunology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M