Synthesis of optically active lipopeptide analogs from the outer membrane of Escherichia coli.
The synthesis of optically active lipopeptide derivatives has been accomplished by the use of chiral glycerol derivatives. Lipopeptide derivatives with (R)-glycerol moieties showed higher mitogenic activities than those with the (S)-configuration. N-2,2,2-Trichloroethoxycarbonyl lipopeptide derivatives increased mitogenic activity.
Kurimura
M
M
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Takemoto
M
M
Achiwa
K
K
D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000138:chemical synthesis* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D004926:Escherichia coli / Q000378:metabolism*; D008074:Lipoproteins / Q000138:chemical synthesis* / Q000494:pharmacology; D008934:Mitogens / Q000138:chemical synthesis / Q000494:pharmacology; D008969:Molecular Sequence Data; D013237:Stereoisomerism
D001425:Bacterial Outer Membrane Proteins; D008074:Lipoproteins; D008934:Mitogens