title: The effect of clonidine in the treatment of acute mania.
abstract: Twenty hospitalized patients have been treated for acute mania with doses of 450-750 micrograms/day of clonidine (an alpha 2-adrenergic agonist), for one month. The tolerance to the given doses was excellent. A marked decrease of the manic symptoms was noted in 65% of the patients during the first 10 days of the treatment. The response was prompt and maintained for the whole period of the research, the clonidine being efficient on the whole scale of the manic syndrome. The sedating effect was much lower than in the case of neuroleptics; it is quite likely that the clonidine could represent an advance in the acute treatment of manic patients.
authors.affiliation: Institute of Neurology and Psychiatry, Bucharest, Romania.
authors.forename: B
authors.initials: B
authors.lastname: Tudorache
authors.forename: S
authors.initials: S
authors.lastname: Diacicov
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy*; D003000:Clonidine / Q000008:administration & dosage*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D008094:Lithium; D006220:Haloperidol; D003000:Clonidine