[The experimental effect of the copolymer of 1-vinyl-3-methyl imidazole iodide with maleic acid diethyl ester on blood coagulability].
The antiheparin activity and acute toxicity of the copolymer of 1-vinyl-3-methyl inidazol iodide (VMII) with diethyl ether of maleic acid (DEMA) were investigated. It was shown that the injection of DEMA group to the molecule of VMII polymer was adequate for storage of a high antiheparin activity of the polymer with the structure. This composition of the copolymer has a low acute toxicity and high selectivity to heparin in the blood. Thrombocytopenia effect is absent.
Afanas'eva
G V
GV
Antonovich
A A
AA
Efimov
V S
VS
Smirnov
A I
AI
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D006494:Heparin Antagonists / Q000494:pharmacology* / Q000633:toxicity; D007093:Imidazoles / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D008298:Maleates / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D013997:Time Factors
D006494:Heparin Antagonists; D007093:Imidazoles; D008298:Maleates; C073477:1-vinyl-3-methylimidazole-maleic acid diethyl ester copolymer; C014476:diethyl maleate
Vliianie sopolimera 1-vinil-3-metil imidazoliĭ ĭodida s diétilovym éfirom maleinovoĭ kisloty na svertyvaemost' krovi v éksperimente.