Effect of dimethyl sulfoxide on lysine production by a mutant of Bacillus subtilis with homoserine dehydrogenase activity.
Some Bacillus subtilis mutants with different levels of homoserine dehydrogenase were described. Strains that do not accumulate methionine have a high homoserine dehydrogenase activity. Low activity was detected in mutants where cell growth was completely inhibited by 0.7 mmol/L methionine. A low concentration of dimethyl sulfoxide had a stimulatory effect on lysine production by the methionine-sensitive mutant of Bacillus subtilis.
Kalcheva
H O
HO
Institute of Molecular Biology and Genetics, Kiev, USSR.
Shanskaya
V O
VO
Smutny
J
J
Maluta
S S
SS
D001412:Bacillus subtilis / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D003545:Cysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006715:Homoserine Dehydrogenase / Q000378:metabolism; D008239:Lysine / Q000096:biosynthesis; D009154:Mutation
C000204:S-2-aminoethyl cysteine; D006715:Homoserine Dehydrogenase; D008239:Lysine; D003545:Cysteine; D004121:Dimethyl Sulfoxide