Absorption, degradation and excretion of benzo(a)pyrene in the cricket (Acheta domesticus).
1. The absorption, degradation and excretion of 3H-benzo(a)pyrene (3H-BP) was examined in the cricket (Acheta domesticus). 2. After 3H-BP injection, extractable 3H-BP declined in the internal compartment over a 48 period. 3. When 3H-BP was deposited on the surface of the insect it penetrated through the cuticle, as evidenced by decrease in 3H-BP recovered in surface rinses and accumulation of 3H-BP internally. 4. Administration of 3H-BP by topical application or injection resulted in a progressive association of radioactivity with tissue debris and low-level metabolism to highly polar compounds. Both parent compound and highly polar metabolites were detected in excreta. 5. Treatment of insects with piperonyl butoxide decreased accumulation of polar products in excreta after injection of 3H-BP.
Kumi
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Department of Biological Sciences, Simon Fraser University, Burnaby, Canada.
Nicholson
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Law
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D000042:Absorption; D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D001673:Biodegradation, Environmental; D006135:Gryllidae / Q000378:metabolism*; D008297:Male; D010882:Piperonyl Butoxide / Q000494:pharmacology; D014018:Tissue Distribution
D001564:Benzo(a)pyrene; D010882:Piperonyl Butoxide