[Effect of emulsions of carbon perfluoride compounds on the blood plasma complement system and functional state of the rabbit brain].
Experiments were conducted in vitro on rabbits to study the effect of emulsions based on composition of carbon perfluorides (decalin perfluoride/methyl cyclohexyl piperidine perfluoride) and proxanol (P-268) on the blood complement system. It is shown that despite preservation of the composition some emulsions activate complement others fail to do this. Intravenous infusion of complement-activating emulsion in a test-dose leads to early neutropenic reaction in the peripheral blood of rabbits and intensified power of low frequency rhythms in the electrocorticogram.
Berkos
M V
MV
Vorob'ev
V V
VV
Piatovskaia
N N
NN
Kukushkin
N I
NI
Sedova
L A
LA
D000818:Animals; D001921:Brain / Q000187:drug effects*; D003165:Complement System Proteins / Q000187:drug effects*; D004655:Emulsions; D005466:Fluorocarbons / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010880:Piperidines / Q000494:pharmacology*; D011817:Rabbits
D004655:Emulsions; D005466:Fluorocarbons; D010880:Piperidines; C008805:perfluorodecalin; C074969:methylcyclohexyl piperidine perfluoride; D003165:Complement System Proteins
Vliianie émul'siĭ perftoruglerodnykh soedineniĭ na sistemu komplementa plazmy krovi i funktsional'noe sostoianie mozga krolikov.