Three-stage stochastic epidemic model: an application to AIDS.
A three-stage stochastic epidemic model extending the so-called classical epidemic process to one that includes time-dependent transition probabilities is described, and a solution to the appropriate set of forward differential-difference equations is given. When an individual can move from being a susceptible to one infected with the HIV virus to one diagnosed as having AIDS, we can use this general model to describe an AIDS epidemic process. We obtain expressions for the mean and variance of the number of AIDS cases for some special cases. By comparing these with actual data, it is suggested that, for some categories of cases (in particular, children), this model might be a plausible model to describe the underlying mechanism of the AIDS epidemic.
Billard
L
L
Department of Statistics, University of Georgia, Athens 30602.
Zhao
Z
Z
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology*; D004196:Disease Outbreaks / Q000706:statistics & numerical data; D006801:Humans; D008954:Models, Biological; D013269:Stochastic Processes