title: Liposomes as carriers of cyclosporin A.
abstract: Liposomes prepared from 1,2-dimyristoyl-sn-3-phosphatidylglycerol (DMPG) and 1,2-dimyristoyl-sn-3-phosphatidylcholine (DMPC) containing cyclosporin A (CsA) were reviewed in respect of the amount and localization of associated CsA. It was found that DMPG liposomes are capable of binding a much higher amount of CsA than those prepared from DMPC. Furthermore, while CsA associated with DMPG was embedded within the hydrophobic region of phospholipids, CsA associated with DMPC was excluded from the hydrophobic region and was entrapped in the hydrophilic region of these liposomes.
authors.affiliation: Department of Clinical Biochemistry, Banting Institute, Faculty of Medicine, University of Toronto, Ontario, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Stuhne-Sekalec
authors.forename: N Z
authors.initials: NZ
authors.lastname: Stanacev
mesh_terms: D016572:Cyclosporine / Q000008:administration & dosage* / Q000737:chemistry; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry / Q000494:pharmacology*; D010715:Phosphatidylglycerols / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D010715:Phosphatidylglycerols; D016572:Cyclosporine; C002773:dimyristoylphosphatidylglycerol; D004134:Dimyristoylphosphatidylcholine