Toxicokinetics of aromatic amines in guppy, Poecilia reticulata.
In this study the elimination kinetics of several chlorinated anilines and a tetrachlorobenzene in guppy, Poecilia reticulata, have been determined. The elimination of all the chlorinated anilines in fish showed a bi-phasic pattern, whereas the elimination characteristics of the tetrachlorobenzene are in agreement with a one-compartment model. Elimination of the chlorinated anilines is faster than elimination of the tetrachlorobenzene. The small differences in octanol-water partition coefficient of these compounds can only in part describe the differences in elimination rate. The observed differences might be attributed to differing biotransformation rates.
de Wolf
W
W
Research Institute of Toxicology, University of Utrecht, Netherlands.
Yedema
E
E
Seinen
W
W
Hermens
J L
JL
D000814:Aniline Compounds / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D002722:Chlorobenzenes / Q000378:metabolism* / Q000633:toxicity; D006207:Half-Life; D007700:Kinetics; D011036:Poecilia / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D002722:Chlorobenzenes; C074538:2,3,5,6-tetrachloroaniline; C074537:2,3,4,5-tetrachloroaniline; C030387:1,2,3,5-tetrachlorobenzene; C027673:2,3,4,5,6-pentachloroaniline