title: Visual evoked responses in tuberculous children on ethambutol therapy.
abstract: Visual evoked responses (VERs) were recorded in 47 children, aged 3-13 years with tuberculosis, treated with ethambutol (20 mg/kg/day) as a part of the antitubercular regimen. VERs were evoked by monocular whole field stimulation, the stimulus being provided by a black and white checker-board pattern reversed every 560 msec and recorded before the commencement, 2, 4, 6, 9 and 12 months of therapy and between 3 to 6 months after stopping the drug. In the first 6 months of therapy the mean values of latency ranged from 92.8 to 101.3 msec in the 3 to less than 6 years age group and 88.5 to 100.3 msec in children 6-13 years of age. Between 6-12 months of therapy the mean values of latency were between 93.3 to 101.0 msec in the 3 to less than 6 years age group and 96.0 to 101.5 msec in the older group. Between 3-6 months after stopping therapy the means of latency ranged from 92 to 96 msec. The differences were not statistically significant at any point of time. Thus, children do not seem to be at greater risk for developing ethambutol inducted optic damage as compared to adults. Ethambutol in the above stated dose may, therefore, be recommended for inclusion in antitubercular chemotherapy in pediatrics without undue fear of subclinical toxicity.
authors.affiliation: Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
authors.forename: V
authors.initials: V
authors.lastname: Seth
authors.forename: P K
authors.initials: PK
authors.lastname: Khosla
authors.forename: O P
authors.initials: OP
authors.lastname: Semwal
authors.forename: V
authors.initials: V
authors.lastname: D'Monty
mesh_terms: D002648:Child; D002675:Child, Preschool; D004977:Ethambutol / Q000009:adverse effects* / Q000627:therapeutic use; D005074:Evoked Potentials, Visual / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009900:Optic Nerve / Q000187:drug effects / Q000503:physiopathology; D009902:Optic Neuritis / Q000139:chemically induced* / Q000503:physiopathology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D004977:Ethambutol