A new dosage form comprising a suspension of activated carbon particles adsorbing aclarubicin: toxicity in mice.
A new dosage form (ACR-CH), a suspension of small activated carbon particles adsorbing aclarubicin, was studied for its toxicity and histopathological effects on organs in mice. The 50% lethal subcutaneous dose of ACR-CH was 83.5 mg/kg, a value 2.42 times that (34.5 mg/kg) of the aclarubicin aqueous solution. The duration of the toxic effects of ACR-CH was prolonged compared with that of the aclarubicin aqueous solution. On autopsy there was no remarkable difference in macroscopic and microscopic examinations between the two dosage forms.
Hagiwara
A
A
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Takahashi
T
T
Iwamoto
A
A
Yoneyama
C
C
Ito
M
M
Sasabe
T
T
Muranishi
S
S
Matsumoto
S
S
D015250:Aclarubicin / Q000008:administration & dosage* / Q000633:toxicity; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002244:Carbon; D005260:Female; D007422:Intestines / Q000473:pathology; D007928:Lethal Dose 50; D051379:Mice; D012867:Skin / Q000473:pathology; D013154:Spleen / Q000473:pathology; D013535:Suspensions; D013950:Thymus Gland / Q000473:pathology
D013535:Suspensions; D002244:Carbon; D015250:Aclarubicin