title: Fish and fish oil intake: effect on haematological variables related to cardiovascular disease.
abstract: To investigate the effects of practical amounts of n-3 highly-unsaturated fatty acids (HUFA) on a number of parameters involved in haemostasis, 12 healthy men were fed three diets in a 3 x 3 cross-over design. The diets, fed as the evening meal for 6-week periods, were: Control diet (essentially fish-free), Fish diet (200 g/d of lean Australian fish flesh) and the same fish-based diet but supplemented with 5 g/d fish oil (Fish + Oil). The diets supplied about 0, 0.6, and 2.0 g n-3 HUFA/d, respectively. Relative to the Control diet, the number of circulating leukocytes was significantly reduced after both the Fish and Fish + Oil diets (by 13% and 15%, respectively). This reduction occurred in the number of neutrophils, although this did not reach significance on the Fish diet alone. Platelet count fell on the Fish + Oil diet (by 6%) but not on the Fish diet alone. There was an apparent enhancement of fibrinolytic potential after both fish-containing diets, which tended to be accentuated with the fish oil supplementation. The mechanisms underlying some if not all of these observations may be eicosanoid-mediated as indicated by a diminution in the platelet arachidonic acid (20:4n-6) to eicosapentaenoic acid (20:5n-3) ratios after the Fish + Oil (13.7 +/- 1.8) and Fish (34.4 +/- 8.9) diets relative to the Control diet (66.1 +/- 15.6). These data suggest that a practical amount of lean fish can improve certain haematological parameters implicated in the etiology of cardiovascular disease.
authors.affiliation: Human Nutrition Unit, University of Sydney, N.S.W., Australia.
authors.forename: A J
authors.initials: AJ
authors.lastname: Brown
authors.forename: D C
authors.initials: DC
authors.lastname: Roberts
mesh_terms: D000818:Animals; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control*; D002462:Cell Membrane / Q000502:physiology; D004032:Diet; D015777:Eicosanoids / Q000097:blood; D005167:Factor VII / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology; D005395:Fish Oils / Q000494:pharmacology*; D005399:Fishes; D006403:Hematologic Tests; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D010976:Platelet Count
chemical_list: D015777:Eicosanoids; D005227:Fatty Acids; D005395:Fish Oils; D005167:Factor VII; D005340:Fibrinogen