title: Controlled release of hydrocortisone acetate from dermal bases.
abstract: The effect of the complexation with beta-cyclodextrin, hydroxypropyl beta-cyclodextrin and polyvinylpyrrolidone on the diffusion kinetics of hydrocortisone acetate through a non porous lipidic membrane was analyzed starting from different dermal bases: a Carbopol gel and lanovaseline. A constant diffusive gradient was achieved; this suggests that the complexation equilibrium controls the diffusable form, according to its stability constant. The following sequence was observed for the cumulative amount diffused: hydrocortisone acetate greater than hydrocortisone acetate/polyvinylpyrrolidone greater than hydrocortisone acetate/hydroxypropyl beta-cyclodextrin greater than hydrocortisone acetate/beta-cyclodextrin. Such behaviour was analyzed in terms of the main physical chemical parameters of the systems examined.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Bologna, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Orienti
authors.forename: V
authors.initials: V
authors.lastname: Zecchi
authors.forename: G
authors.initials: G
authors.lastname: Ceschel
authors.forename: A
authors.initials: A
authors.lastname: Fini
mesh_terms: D000180:Acrylic Resins; D000287:Administration, Topical; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003505:Cyclodextrins / Q000008:administration & dosage; D004058:Diffusion; D006854:Hydrocortisone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008567:Membranes, Artificial; D011145:Polyvinyls / Q000008:administration & dosage; D011205:Povidone / Q000008:administration & dosage; D012826:Silicone Elastomers; D047392:beta-Cyclodextrins
chemical_list: D000180:Acrylic Resins; D003505:Cyclodextrins; D008567:Membranes, Artificial; D011145:Polyvinyls; D012826:Silicone Elastomers; D047392:beta-Cyclodextrins; C006912:carboxypolymethylene; C021650:hydrocortisone acetate; D011205:Povidone; C031215:betadex; D006854:Hydrocortisone