Protection of Pseudomonas aeruginosa against ciprofloxacin and beta-lactams by homologous alginate.
Pseudomonas aeruginosa-derived alginate but no other neutral and negatively charged polysaccharides protected mucoid and nonmucoid strains of that organism against ciprofloxacin, gentamicin, ticarcillin, and ceftazidime. Data indicate that alginate has an intrinsic protective effect which is independent of diffusion, charge, or biofilm phenomena.
Hodges
N A
NA
Department of Pharmacy, Brighton Polytechnic, United Kingdom.
Gordon
C A
CA
D000464:Alginates / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002939:Ciprofloxacin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003550:Cystic Fibrosis / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D011134:Polysaccharides / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D047090:beta-Lactams
D000464:Alginates; D000900:Anti-Bacterial Agents; D011134:Polysaccharides; D047090:beta-Lactams; D002939:Ciprofloxacin