A new method for the evaluation of the liver injury by 19F MRS of 5-fluorouracil.
An investigation was made of 5-fluorouracil metabolism in rat liver by 19F MRS. Fluoronucleotide synthesis increased markedly with liver injury and accelerated with uracil treatment, indicating that 19F MRS may serve as a new method for evaluating liver viability.
Harada
M
M
Department of Radiology, School of Medicine, Tokushima University, Japan.
Koga
K
K
Miura
I
I
Nishitani
H
H
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D005472:Fluorouracil / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY
D005472:Fluorouracil