[Aminomethyl derivatives of (benzisothiazolin-3-one-2-yl)acetic acid amides and 2-(1,2-benzisothiazoline-3-one-2-yl)propionic acid amides].
In the search for pharmacological active new derivatives of 1,2-benzisothiazolin-3-on amides of (3-oxo-1,2-benzisothiazolin-2-yl)acetic acid and 3-(3-oxo-1,2-benzisothiazolin-2-yl)propionic acid were obtained. In the reaction of these amides with formaldehyde and various second aryl amines the title compounds are formed. Morpholinmethylamide of (3-oxo-1,2-benzisothiazolin-2-yl)acetic acid showed activity against Trichomonas vaginalis. In the reaction of ethyl esters of (3-oxo-1,2-benzisothiazolin-2-yl) acetic- and -propionic acids with hydrazine hydrate products of ring-opening of isothiazole-2,2'-dithio-bis [N- (ethoxycarbonylmethyl)benzamide] and 2,2'-dithio-bis[N-(ethoxycarbonylethyl)benzamide are formed.
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Lehrstuhl für Pharmazeutische Chemie, Pharmazeutische Fakultät, Medizinischen Akademie Lublin, Polen.
D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology; D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000994:Antitrichomonal Agents / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000081:Acetamides; D000577:Amides; D000994:Antitrichomonal Agents; D011422:Propionates; D013844:Thiazoles
Aminomethylderivate des (1,2-Benzisothiazolin-3-on-2-yl)essigsäureamids und 3-(1,2-Benzisothiazolin-3-on-2-yl)propionsäureamids.