title: [Synthesis of 2,6-dimethyl-4-disubstituted phenyl-1,4-dihydropyridine-3,5-dicarboxylates as antimyocardial ischemic agents].
abstract: Nine title compounds were synthesized as potential antimyocardial ischemic agents. After screening, some of these compounds were found to exhibit calcium-blocking activity. Among them, the antagonism of compound I6 (diethyl 4-(3-methoxy-4-[(2-hydroxy-3-isopropylamino)propoxy] phenyl)-1,4- dihydropyridine-3,5-dicarboxylates) was the most potent in the potassium- stimulated rabbit aortic strip. Compound I6 was subjected to further pharmacological assay, and it was shown to increase coronary flow and cardiac output of isolated rabbit heart, reduce myocardial oxygen consumption, decrease myocardial infarct size of rat, and increase the tolerance of mice to hypoxia.
authors.affiliation: Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Yan
authors.forename: Y M
authors.initials: YM
authors.lastname: Dong
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D011817:Rabbits; D051381:Rats
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines