[Functional properties of B-lymphocytes of patients with a B-cell variant of chronic lymphocytic leukemia and chronic glomerulonephritis].
The common features of the pathogenesis of chronic lymphocytic leukemia (CLL) and chronic glomerulonephritis (CGN) have been shown as a result of a comprehensive study of the functional properties of B cells. Both CLL and CGN are accompanied by the appearance and accumulation of different types of activated B cells characterized by high spontaneous proliferation and/or Ig secretion; or sensitivity to T cell growth and differentiation factors; or capacity for Ig secretion; in mitomycin C treated B cell cultures (i.e. without previous proliferation). The present data may be useful in the integral evaluation of B cell function in health and in immunopathologies (lymphoproliferative and autoimmune/immune complex diseases).
Ostanin
A A
AA
Chernykh
E R
ER
Shubinskiĭ
G Z
GZ
Nekipelova
V I
VI
Tov
N L
NL
Lozovoĭ
V P
VP
D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D001782:Blood Donors; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002908:Chronic Disease; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D066298:In Vitro Techniques; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology* / Q000473:pathology; D007958:Leukocyte Count; D009367:Neoplasm Staging; D012016:Reference Values
D007136:Immunoglobulins
Funktsional'nye svoĭstva B-limfotsitov bol'nykh B-kletochnym variantom khronicheskogo limfoleĭkoza i khronicheskim glomerulonefritom.