Morphological and biochemical characteristics in the experimentally treated rats with indigenous synthetical products used as pesticides.
In acute experimental intoxication with 3 indigenous pesticides (Tripinacloraz, Lemax and Maleic Hydrazide-Na salt) the changes of some biochemical parameters, reflecting the degree of hepatic structural alterations, were studied. The pesticides were administered by gastric gavage in a single dose close to DL50 to Wistar male rats. The morphological alterations were in good correlation with a different hepatocellular levels localization. Reversible morphological lesions (granulovascuolar like dystrophy and circulatory disorders) without any pathological significance on dose-effect correlation induced a progressive response especially on serum ceruloplasmine, leucinaminopeptidase and lactatdehydrogenase.
Filipescu
G
G
Victor Babeş Institute, Department of Pathology, Bucharest, Romania.
Codorean
E
E
Laky
D
D
Tănase
C
C
Ciotaru
L
L
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008107:Liver Diseases / Q000201:enzymology / Q000473:pathology; D008297:Male; D008300:Maleic Hydrazide / Q000633:toxicity; D010575:Pesticides / Q000633:toxicity*; D010797:Phthalimides / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D014230:Triazoles / Q000633:toxicity
D010575:Pesticides; D010797:Phthalimides; D014230:Triazoles; C032910:triadimefon; C073724:Lemax; D008300:Maleic Hydrazide