The influence of oestrone on the production of tumour necrosis factor by human peripheral blood adherent cells.
Human peripheral blood adherent cells (PBAC) incubated with oestrone in high concentration (10(-5) M) release, on exposure to bacterial endotoxin, an amount of tumour necrosis factor (TNF) greater than do cells incubated without the steroid. The finding may imply a non-endocrine hormonal process leading to heightened local TNF responses. This may be the basis of endotoxin hypersensitivity in pregnancy.
Stark
J M
JM
Department of Medical Microbiology, University of Wales College of Medicine, Cardiff, U.K.
Neale
M L
ML
D004731:Endotoxins / Q000494:pharmacology; D004970:Estrone / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D004731:Endotoxins; D014409:Tumor Necrosis Factor-alpha; D004970:Estrone