A mathematical model of the kinetics of platelets and plasma hemostasis system interaction.
A mathematical model of the kinetics of platelet-activated blood coagulation is presented. Non-linear positive feedbacks due to the action of co-factor Va and VIIIa, thrombin-induced platelet activation, the secretion of factor V by platelets are taken into account. The intrinsic pathway is shown not to be activated in the absence of platelets for small stimulation intensities. The activation occurs if initial platelet activation by inductors other than thrombin exceeds a threshold value.
Khanin
M A
MA
Department of Microelectronics, K. E. Tziolkovsky Institute of Aviation Technology, Moscow, USSR.
Leytin
V L
VL
Popov
A P
AP
D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000502:physiology*; D005246:Feedback / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological