title: Osteoporosis in patients affected with thalassemia. Our experience.
abstract: The authors examine 72 patients affected with homozygous B-thalassemia; The study was conducted by clinical-hematological and radiologic examination. The Singh method is used to compare clinical data with the degree of osteoporosis. The results indicate that there is a high frequency of osteoporotic abnormalities in thalassemia. The authors postulate that osteoporotic lesions are principally caused by hyperplasia of the marrow, the overactive bone marrow widening the medullary space and the increased intramedullary pressure causing osteoporosis.
authors.affiliation: Istituto dell'Apparato Locomotore e Chirurgia d'Urgenza, 2a Facoltà, Università, Napoli.
authors.forename: E
authors.initials: E
authors.lastname: Giuzio
authors.forename: M
authors.initials: M
authors.lastname: Bria
authors.forename: M G
authors.initials: MG
authors.lastname: Bisconte
authors.forename: M
authors.initials: M
authors.lastname: Caracciolo
authors.forename: A
authors.initials: A
authors.lastname: Qualtieri
authors.forename: M
authors.initials: M
authors.lastname: Misasi
authors.forename: G
authors.initials: G
authors.lastname: Grillo
authors.forename: C
authors.initials: C
authors.lastname: Brancati
mesh_terms: D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010024:Osteoporosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D013789:Thalassemia / Q000150:complications* / Q000628:therapy