Cancer treatment with interleukins 1, 4 and 6 and combinations of cytokines: a review.
During the last few years the anticancer effects of recombinant cytokines has been studied in animal experiments and in clinical trials. Significant anticancer effects of especially, interleukin-2 (IL-2) and interferon alpha (IFN alpha) have been obtained. In this paper, we shall focus on the studies and possible applications of interleukin 1 (IL-1), interleukin 4 (IL-4), interleukin 6 (IL-6) as single agents and focus on some combinations of cytokines. Finally, we shall discuss future developments that can be expected.
Dullens
H F
HF
Instituut voor Pathologie, Academisch Ziekenhuis, Utrecht, The Netherlands.
De Wit
C L
CL
D000818:Animals; D016207:Cytokines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007375:Interleukin-1 / Q000627:therapeutic use; D015847:Interleukin-4 / Q000627:therapeutic use; D015850:Interleukin-6 / Q000627:therapeutic use; D009369:Neoplasms / Q000628:therapy*
D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D015847:Interleukin-4