title: The application of QSARs, extrapolation and equilibrium partitioning in aquatic effects assessment for narcotic pollutants.
abstract: QSAR estimates of toxicity of relatively unreactive organic chemicals for 19 species of bacteria, algae, fungi, protozoans, coelenterates, rotifers, molluscs, crustaceans, insects, fish and amphibians were used to predict 'no-effect-levels' (NELs) at the ecosystem level by means of a recently developed extrapolation model. Equilibrium-partitioning theory for sediment and water was used to derive NELs for aquatic sediments. A simple table is given from which NELs for water and sediments can be predicted on the basis of only the octanol-water partition coefficient and molecular weight.
authors.forename: C J
authors.initials: CJ
authors.lastname: Van Leeuwen
authors.forename: P T
authors.initials: PT
authors.lastname: Van der Zandt
authors.forename: T
authors.initials: T
authors.lastname: Aldenberg
authors.forename: H J
authors.initials: HJ
authors.lastname: Verhaar
authors.forename: J L
authors.initials: JL
authors.lastname: Hermens
mesh_terms: D000818:Animals; D008433:Mathematics; D009294:Narcotics / Q000737:chemistry / Q000633:toxicity*; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014116:Toxicology / Q000379:methods; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D009294:Narcotics; D014874:Water Pollutants, Chemical