[Quality control studies of 3 deep-frozen coagulation-active fresh frozen plasma preparations from various suppliers and a new virus-inactivated lyophilized pooled plasma preparation].
Fresh frozen plasma is the most important therapeutic agent in acquired coagulation disorders. We investigated the quality of three conventional fresh-frozen plasma preparations (groups I, II, IV) and one new virus-inactivated lyophilised pooled plasma preparation (group III). In the new plasma preparation we found a significant reduction in coagulation activity, a significantly higher pH value and a highly significant rise in plasma heparin levels. No significant difference in electrolytes, protein levels and concentration or complement activity was found in any of the groups. In conclusion, unlike conventional fresh-frozen plasma, this new virus-inactivated lyophilised pooled plasma preparation does not seem to be suitable for use in therapy of coagulation disorders.
Hügler
P
P
Klinik für Anästhesiologie, Ruhr-Universität Bochum, St. Josef-Hospital.
Trobisch
H
H
Neumann
H A
HA
Möller
J H
JH
Sirtl
C
C
Derdak
M
M
Laubenthal
H
H
D000998:Antiviral Agents / Q000494:pharmacology*; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D001798:Blood Proteins / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D004573:Electrolytes / Q000032:analysis; D005612:Freeze Drying; D006801:Humans; D010949:Plasma / Q000737:chemistry* / Q000382:microbiology; D011786:Quality Control; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D001779:Blood Coagulation Factors; D001798:Blood Proteins; D004573:Electrolytes; D003165:Complement System Proteins
Qualitätskontrollstudien an 3 tiefgefrorenen gerinnungsaktiven Frischplasmapräparaten verschiedener Hersteller und einem virusinaktivierten lyophilisierten Poolplasmapräparat.