Androgen metabolism in control and neonatally estrogenized male mice.
Reduction, oxidation, and aromatization of androgens were studied in the male genital tract of untreated control and neonatally estrogenized mice. This study shows regional differences in 5 alpha-reductase and 17 beta-hydroxysteroid oxidoreductase activities in untreated male genital tract; 3 alpha/3 beta-hydroxysteroid oxidoreductase (3 alpha/3 beta-HSOR) activity varied little between tissues. Neonatal treatment with diethylstilbestrol (DES, 2 micrograms/pup/day on days 1 through 5) caused an alteration in the androgen metabolism of the male genital tract, resulting in apparent decreased net accumulation of dihydrotestosterone (DHT). This developmentally-induced 5 alpha-reductase deficiency may play a role in the long-term inhibitory effects of early estrogenization by DES in the growth and function of male sex accessory glands. No aromatase activity could be demonstrated in the male genital tract of control or neonatally estrogenized mice.
Santti
R
R
Developmental Endocrinology and Pharmacology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Newbold
R R
RR
McLachlan
J A
JA
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D004054:Diethylstilbestrol / Q000494:pharmacology*; D005837:Genitalia, Male / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction
D000728:Androgens; D004054:Diethylstilbestrol