title: [Neonatal septicemia and meningitis caused by gram-negative bacilli in Yaondé: clinical, bacteriological and prognostic aspects].
abstract: Based on 139 cases collected in 36 months, the authors show that neonatal sepsis and meningitis with Gram negative bacilli represent 62.33% of confirmed neonatal sepsis (223 cases out of 6,784 neonatal hospitalisations). 53.96% of cases are manifest within the first 72 hours of life. 35.25% of these infants are preemies. The principal predisposing factors are: foul-smelling leukorrhea (45.23%), prolonged rupture of membranes (26.62%) and notion of resuscitation (36.69%). The most important clinical signs are: thermal dysregulation (47.48%), tonus disturbances (35.97%) and respiratory distress (25.90%). Sepsis make up 85.61% of cases; the principal germs isolated being: Acinetobacter (21.58%), Pseudomonas (15.83%), Escherichia coli (14.39%), Enterobacter (12.95%), Klebsiella (11.51%). Of the germs isolated, 27.78% were resistant to initial treatment with the association ampicillin gentamicin. Mortality rate was 46.76%.
authors.affiliation: Unité de Pédiatrie, Centre Universitaire des Sciences de la Santé (CUSS), Hôpital Central de Yaoundé, Cameroun.
authors.forename: I
authors.initials: I
authors.lastname: Kago
authors.forename: M
authors.initials: M
authors.lastname: Wouafo Ndayo
authors.forename: P F
authors.initials: PF
authors.lastname: Tchokoteu
authors.forename: P
authors.initials: P
authors.lastname: Koki Ndombo
authors.forename: T
authors.initials: T
authors.lastname: Ekoe
authors.forename: P
authors.initials: P
authors.lastname: Doumbe
authors.forename: F
authors.initials: F
authors.lastname: Tietche
authors.forename: H
authors.initials: H
authors.lastname: N'Koulou
mesh_terms: D000150:Acinetobacter / Q000187:drug effects / Q000302:isolation & purification; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D002163:Cameroon / Q000453:epidemiology; D004754:Enterobacter / Q000187:drug effects / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D007709:Klebsiella / Q000187:drug effects / Q000302:isolation & purification; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D011379:Prognosis; D011511:Proteus / Q000187:drug effects / Q000302:isolation & purification; D011549:Pseudomonas / Q000187:drug effects / Q000302:isolation & purification; D012737:Sex Factors
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Les septicémies et méningites néonatales a bacilles gram négatifs a Yaoundé: aspects cliniques, bactériologiques et pronostiques.