Metabolic biomarkers of Parkinson's disease.
Enzymic systems involved with metabolism of foreign chemicals, xenobiotics, have been studied in Parkinson's disease. Enzymes involved with sulphur oxidation and methylation are under-active. Cysteine levels are high and sulphate levels low. Differences in the activity of the enzyme monoamine oxidase-B are evident. Pathways involved with N-methylation of pyridines are different from controls leading to a rise in potentially toxic N-methylated derivatives.
Williams
A
A
University Department of Neurology, University of Birmingham, Edgbaston, UK.
Sturman
S
S
Steventon
G
G
Waring
R
R
D002233:Carbocysteine; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008780:Methyltransferases / Q000097:blood*; D008995:Monoamine Oxidase / Q000097:blood*; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000175:diagnosis* / Q000201:enzymology; D012307:Risk Factors; D013454:Sulfoxides / Q000652:urine*
D007527:Isoenzymes; D013454:Sulfoxides; D002233:Carbocysteine; D008995:Monoamine Oxidase; D008780:Methyltransferases