[Experimental studies of administration of perfluoroalkane to the anterior chamber and vitreous body of rabbits].
Presented are the results of experimental investigations evaluating the influence of perfluoroalcane on the ocular tissue in rabbits. The examined animals were divided into 2 groups. The rabbits from the first one received the compound into the anterior chamber of the right eye, the rabbits from the 2-nd group to the vitreous of the right eye. The left eye was the control one. Evaluated was the degree of absorption of the compound from the anterior chamber and vitreous, its influence on the anterior segment, transparency of the lens and intraocular pressure. An ERG was performed before the application of the compound and after 7, 14 and 49 days; subsequently the eyes were excised and a histopathological examination was performed in a light microscope.
Karczewicz
D
D
I i II Kliniki Okulistycznej AM w Szczecinie.
Mozolewska
K
K
Lubiński
W
W
Lubiński
J
J
Meissner
E
E
D000042:Absorption; D000473:Alkanes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005466:Fluorocarbons / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008954:Models, Biological; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors; D014822:Vitreous Body / Q000187:drug effects* / Q000378:metabolism
D000473:Alkanes; D005466:Fluorocarbons; C075510:1,1,1,2,3,3,4,4,5,5,6,6,7,8,8,8-hexadecafluoro-2,7-bis(trifluoromethyl)octane
Badania doświadczalne nad zastosowaniem perfluoroalkanu do komory przedniej i ciała szklistego królika.