Effects of oral contraceptive pills on drug metabolizing enzymes and acid soluble sulfhydryl level in mouse liver.
The present paper reports the modulatory influence of two widely used combined oral contraceptive pills "OVRAL" and "NORACYCLINE" on hepatic phase I and II drug metabolizing enzymes and acid soluble sulfhydryl group of the mouse. Three different doses of the pills were used in this study i.e. D1 (1/2000th of a pill), D2 (1/200th of a pill) and D3 (1/20th of a pill). The sulfhydryl group increased significantly with the D1 and D2 dose of Ovral and the D2 dose of Noracycline. Dose D2 of both pills decreased cyt.P450 and cyt.b5 contents. D3 of Noracycline, however increased both the cytochrome levels. Dose D3 of Ovral and all three doses of Noracycline reduced the glutathione S-transferase activity.
Hussain
S P
SP
Department of Carcinogenesis, Institut Suisse De Recherches Experimentales Sur Le Cancer, Lausanne.
Chhabra
S K
SK
Rao
A R
AR
D000818:Animals; D001711:Biotransformation / Q000187:drug effects*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D015786:Cytochromes b5 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004789:Enzyme Activation / Q000187:drug effects; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism; D008658:Inactivation, Metabolic; D008234:Lynestrenol / Q000494:pharmacology*; D008656:Mestranol / Q000494:pharmacology*; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D009644:Norgestrel / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000032:analysis*
D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D004338:Drug Combinations; D013438:Sulfhydryl Compounds; D009644:Norgestrel; D004997:Ethinyl Estradiol; C002746:Noracycline; D019304:Ethinyl Estradiol-Norgestrel Combination; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D008656:Mestranol; D005982:Glutathione Transferase; D008234:Lynestrenol