A direct HPLC method for the resolution of glycidyl tosylate and glycidyl 3-nitrobenzenesulphonate enantiomers.
The enantiomeric composition of glycidyl tosylate and glycidyl 3-nitrobenzenesulphonate is obtained using an enantiomeric HPLC column. The chiral oxiranes were resolved on a cellulose carbamate column using a mobile phase of hexane:2-propanol. The method is simple, sensitive and does not require derivatization.
Shaw
C J
CJ
R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869.
Barton
D L
DL
D001557:Benzenesulfonates / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D009578:Nitrobenzenes / Q000032:analysis*; D013237:Stereoisomerism; D014105:Tosyl Compounds / Q000032:analysis*
D001557:Benzenesulfonates; D009578:Nitrobenzenes; D014105:Tosyl Compounds; C075689:glycidyl 3-nitrobenzenesulfonate; C075688:glycidyl tosylate