Microheterogeneity of alpha 1-acid glycoprotein in healthy elderly subjects: patterns obtained by crossed affino-immunoelectrophoresis.
Total serum alpha 1-acid glycoprotein (AGP) concentration and concanavalin A-dependent microheterogeneity were studied in 31 healthy elderly subjects (18 men, 13 women, 71 to 76 yr old). Crossed affino-immunoelectrophoresis (CAIE) revealed three microheterogeneity variants of AGP: non-reactive, weakly reactive and strongly reactive with ConA. Two patterns were found in both elderly men and women, i.e. a normal pattern and one with an increase in the non-reactive form. Mean serum AGP levels in the elderly subjects with slightly higher than in a reference group of younger subjects. The Con A non-reactive form of AGP was increased in 42% of the elderly population. An increase in the non-reactive form of AGP in CAIE should be considered as general expression of chronic inflammation which is of no clinical relevance.
Kawerk
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N
Laboratoire de Biochimie, Hôpital Corentin Celton, Issy les Moulineaux, France.
Succari-Aderschlag
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M
Foglietti
M J
MJ
D000368:Aged; D000375:Aging; D003208:Concanavalin A; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional / Q000379:methods; D008297:Male; D009961:Orosomucoid / Q000032:analysis* / Q000302:isolation & purification; D012016:Reference Values; D012727:Sex Characteristics
D009961:Orosomucoid; D003208:Concanavalin A