[The prediction of the membrane-damaging action of chemical substances in experiments on bacteria].
Comparative study of the cytoplasmic membrane sensitivity in procaryotic cells (E. coli) and eucaryotic cells (rat red blood cells) to bis-quaternary ammonea compounds and diatomic aliphatic alcohols was carried out. Comparative study of the membrane permeability demonstrated, that E. coli is more sensitive for these xenobiotics. Cells of E. coli recommended as a biotest-object for the membrane tropic toxic reactions to study.
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D000438:Alcohols / Q000633:toxicity*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects*; D009994:Osmolar Concentration; D009996:Osmotic Fragility / Q000187:drug effects; D011379:Prognosis; D000644:Quaternary Ammonium Compounds / Q000633:toxicity*; D051381:Rats
D000438:Alcohols; D000644:Quaternary Ammonium Compounds
Prognozirovanie membranopovrezhdaiushchego deĭstviia khimicheskikh veshchestv v opytakh na bakteriiakh.