Experimental evidence of a potentiation by alpha,beta magnesium L-aspartate of the anxiolytic effect of diazepam. Four-plate test in mice and qEEG study in primates.
The anxiolytic dose 50 (AD50) of diazepam was determined in mice in the four-plate test and the EEG pattern elicited by diazepam was quantified by Fast Fourier Transformation in monkeys. The AD50 of diazepam was reduced by 2.7-fold after repeated treatment with alpha,beta magnesium L-aspartate. The increased EEG fast activity elicited by diazepam at the expense of slow activities was reinforced and more long lasting after alpha,beta magnesium L-aspartate treatment.
Borzeix
M G
MG
Institut de Recherche SIR international, Montrouge, France.
Akimjak
J P
JP
Dupont
J M
JM
Cahn
R
R
Cahn
J
J
D000818:Animals; D001007:Anxiety / Q000139:chemically induced* / Q000188:drug therapy; D001224:Aspartic Acid / Q000494:pharmacology*; D003975:Diazepam / Q000009:adverse effects*; D004569:Electroencephalography; D008252:Macaca fascicularis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011581:Psychological Tests
D001224:Aspartic Acid; D003975:Diazepam