The effect of various PGI2 analogues on free and phospholipid-bound fatty acids in rat brain, following complete ischaemia, normobaric and hypobaric hypoxia.
The effect of various prostacyclin analogues on free and phospholipid-bound fatty acids in rat brain following complete ischaemia, normobaric and hypobaric hypoxia were investigated. Both ischaemic and hypoxic conditions cause a significant rise in both unsaturated (arachidonic and docosahexaenoic) and saturated (palmitic and stearic) fatty acids. Under same conditions, a significant fall in phosphatidylinositol level in brain was observed. Prostacyclin and its analogues significantly reduce the rise of free fatty acids, as well as the decrease of phosphatidylinositol.
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Department of Pathophysiology, Veterinary Faculty of Agricultural Academy, Lublin, Poland.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002545:Brain Ischemia / Q000378:metabolism*; D011464:Epoprostenol / Q000031:analogs & derivatives / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D000860:Hypoxia / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D011464:Epoprostenol