title: Rapid electrodialytic clean-up of biological samples for high-performance liquid chromatography.
abstract: A sample clean-up system employing electrodialysis with size-selective and charge-selective membranes is described. When applied to the treatment of 0.5-ml milk samples containing sulfamethazine, the system produced an undiluted, clear solution in 3 min and eliminated the components in untreated milk that caused column fouling and double peaks. In contrast to conventional liquid- and solid-phase extraction procedures, electrodialytic clean-up is readily automated and uses no organic solvents.
authors.affiliation: US Department of Agriculture, ARS, Eastern Regional Research Center, Philadelphia, PA 19118.
authors.forename: J D
authors.initials: JD
authors.lastname: Brewster
authors.forename: E G
authors.initials: EG
authors.lastname: Piotrowski
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003956:Dialysis / Q000379:methods*; D004563:Electrochemistry; D008892:Milk / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet; D013418:Sulfamethazine / Q000032:analysis
chemical_list: D013418:Sulfamethazine