Correlation of tumour-inhibiting activity with acute toxicity.
We have developed predictive equations for the anti-carcinogenic activity of 21 phenolic anti-oxidants against forestomach tumours in mice. One of these equations was then used to predict the anti-carcinogenic activity of a further 25 phenolic compounds. It was found that anti-carcinogenic activity correlated well with acute toxicity to the fathead minnow.
Bradburne
S J
SJ
School of Health Sciences, Liverpool Polytechnic, United Kingdom.
Dearden
J C
JC
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity*; D000975:Antioxidants / Q000627:therapeutic use / Q000633:toxicity*; D003530:Cyprinidae; D010636:Phenols / Q000627:therapeutic use / Q000633:toxicity*; D012044:Regression Analysis; D012984:Software; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D000975:Antioxidants; D010636:Phenols