title: Olfactory sensations produced by high-energy photon irradiation of the olfactory receptor mucosa in humans.
abstract: During irradiation of volumes that incorporate the olfactory system, a proportion of patients have complained of a pungent smell. A retrospective study was carried out to determine the prevalence of this side-effect. A questionnaire was sent to 40 patients whose treatment volumes included the olfactory region and also to a control group treated away from this region. The irradiated tumor volumes included the frontal lobe, whole brain, nasopharynx, pituitary fossa, and maxillary antrum. Of the 25 patients who replied, 60% experienced odorous symptoms during irradiation. They described the odor as unpleasant and consistent with ozone. Stimulation of olfactory receptors is considered to be caused by the radiochemical formation of ozone and free radicals in the mucus overlying the olfactory mucosa.
authors.affiliation: Meyerstein Institute of Radiotherapy, Middlesex Hospital, London, U.K.
authors.forename: S M
authors.initials: SM
authors.lastname: Sagar
authors.forename: R J
authors.initials: RJ
authors.lastname: Thomas
authors.forename: L T
authors.initials: LT
authors.lastname: Loverock
authors.forename: M F
authors.initials: MF
authors.lastname: Spittle
mesh_terms: D000236:Adenoma / Q000532:radiotherapy; D003397:Craniopharyngioma / Q000532:radiotherapy; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D009297:Nasal Mucosa / Q000528:radiation effects*; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy; D009833:Olfactory Pathways / Q000528:radiation effects; D010911:Pituitary Neoplasms / Q000532:radiotherapy; D012189:Retrospective Studies; D011984:Sensory Receptor Cells / Q000528:radiation effects; D012903:Smell / Q000528:radiation effects*; D011795:Surveys and Questionnaires