title: Acute toxicity studies of tri-n-butyltin and triphenyltin acetates in rats.
abstract: Two organotin compounds, tri-n-butyltin acetate (TBTA) and triphenyltin acetate (TPTA), that have antifungal potentials and are intended for use on yam root crops to prevent rot were evaluated for acute mammalian toxicity in rats. The median lethal doses po were 297.54 mg TBTA/kg and 402.38 mg TPTA/kg. Both compounds produced significant central nervous system and respiratory depressions at single doses of 200 mg TBTA/kg or 300 mg TPTA/kg. The histopathological findings due to TBTA included pulmonary, hepatic and renal congestion, brain hemorrhages, and destruction of the intestinal mucosa. TPTA produced brain congestion, and hepatic and pulmonary petechial and generalized hemorrhages.
authors.affiliation: Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: U S
authors.initials: US
authors.lastname: Attahiru
authors.forename: T T
authors.initials: TT
authors.lastname: Iyaniwura
authors.forename: A O
authors.initials: AO
authors.lastname: Adaudi
authors.forename: J J
authors.initials: JJ
authors.lastname: Bonire
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005659:Fungicides, Industrial / Q000008:administration & dosage / Q000633:toxicity*; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000473:pathology; D007928:Lethal Dose 50; D008297:Male; D009947:Organotin Compounds / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D012871:Skin Diseases / Q000139:chemically induced / Q000473:pathology; D014220:Trialkyltin Compounds / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D005659:Fungicides, Industrial; D009947:Organotin Compounds; D014220:Trialkyltin Compounds; C011559:tributyltin; C011978:phentin acetate