Beneficial effect of dexamethasone in decreasing the lethality of acute T-2 toxicosis.
1. Steroidal and non-steroidal anti-inflammatory agents were evaluated for effectiveness for treatment of acute T-2 toxicosis in mice. 2. Non-steroidal agents, indomethacin, phenylbutazone, and acetylsalicylic acid, either were ineffective, or potentiated the lethality of T-2 toxin. 3. Of the anti-inflammatory steroids tested, dexamethasone was the most effective. 4. Dexamethasone was administered before, at the same time as, or after injection of T-2 toxin. 5. As the time between toxin exposure and treatment was increased, there was a corresponding increase in lethality. 6. In conclusion, steroidal, but not non-steroidal, anti-inflammatory agents were effective in decreasing T-2 toxin-induced lethality.
Fricke
R F
RF
U.S. Army Medical Research, Institute of Infectious Diseases, Ft Detrick, Frederick, MD 21701-5011.
Jorge
J
J
D000375:Aging / Q000502:physiology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001835:Body Weight / Q000502:physiology; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013605:T-2 Toxin / Q000037:antagonists & inhibitors* / Q000633:toxicity
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003907:Dexamethasone; D013605:T-2 Toxin