Effect of anticancer drugs on the release of interleukin-3 in vitro.
In this study several anticancer drugs were tested for their effect on the release of interleukin-3 (IL-3) from concanavalin A (Con A) stimulated mouse splenocytes in vitro. When Adriamycin or vincristine were added to the cultures at non-cytotoxic concentrations, the release of IL-3 was inhibited. However, bleomycin, FK156, FK565 and 4-OOH-cyclophosphamide (the in vitro active analogue of the anticancer and immunosuppressive drug cyclophosphamide) did not alter the release of IL-3 under the same conditions. It was confirmed that cyclosporin A inhibited the release of IL-3 in the same experimental system.
Hasan
S I
SI
Department of Pathology, Royal College of Surgeons of England, London, U.K.
Turk
J L
JL
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003208:Concanavalin A / Q000276:immunology; D016572:Cyclosporine / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D066298:In Vitro Techniques; D007377:Interleukin-3 / Q000096:biosynthesis / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D014750:Vincristine / Q000494:pharmacology
D000970:Antineoplastic Agents; D007377:Interleukin-3; D003208:Concanavalin A; D014750:Vincristine; D004317:Doxorubicin; D016572:Cyclosporine