Synthesis and immunopharmacological analysis of selected derivatives of N,N'-bis-/3-aziridine/butanoylalkylenediamines and imides of 3-aziridinesuccinic acid. I.
A series of aziridinederivatives of N,N'-bis-butanoylalkylenodiamines (Scheme 1, 1-4) and aziridinederivatives of substituted succinic acid (Scheme 2, 16-19) was obtained. Pharmacological analysis revealed that these compounds were immunotropic, of marked suppressive effect (PFC, RFC, circulating immunoglobulins). Outstanding in this group was phenyloimide of succinic acid (prep. 16) which reduced PFC and RFC number but increased the level of circulating IgG.
Kowalczyk-Bronisz
S H
SH
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Mojsiejewska
D
D
Pomorski
J
J
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D001388:Aziridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D012397:Rosette Formation; D013329:Structure-Activity Relationship
D001388:Aziridines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents