title: [Interactions of fluconazole and phagocytic cells].
abstract: Fluconazole is a triazole compound with a coefficient of distribution P at pH 7.4 of 1.6 (log P = 0.2), and has thus both hydrophilic and lipophilic properties. The physicochemical and pharmacokinetic profiles of fluconazole are clearly different from those of other azole antimycotics. 3H-labelled fluconazole penetrates very rapidly into granulocytes and monocytes (macrophages) isolated from volunteers. The concentrations of the triazole in the granulocytes are about 28% and in the macrophages about 63% higher than in the extracellular milieu. At the concentrations examined (5, 10 and 20 micrograms ml-1) fluconazole damages cells of Candida albicans which have been phagocytized by granulocytes or by macrophages. A clear synergy between fluconazole and the phagocytes can be demonstrated.
authors.affiliation: Abteilung für Pathologie, Fakultät für Theoretische Medizin, Universität Ulm.
authors.forename: A
authors.initials: A
authors.lastname: Wildfeuer
authors.forename: H
authors.initials: H
authors.lastname: Laufen
authors.forename: O
authors.initials: O
authors.lastname: Haferkamp
mesh_terms: D002176:Candida albicans / Q000187:drug effects* / Q000276:immunology; D002478:Cells, Cultured; D015725:Fluconazole / Q000493:pharmacokinetics / Q000494:pharmacology*; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D009000:Monocytes / Q000378:metabolism*; D010586:Phagocytes / Q000378:metabolism*
chemical_list: D015725:Fluconazole
vernacular_title: Wechselwirkungen von Fluconazol und phagozytierenden Zellen.