Spiperone: a receptor ligand and/or a granular uptake tracer?
The accumulation of [3H]spiperone and [3H]dopamine was measured in striatum and pituitary gland slices of rat. Contrary to [3H]dopamine, [3H]spiperone storage was similar in striatum and pituitary gland. In addition, [3H]spiperone accumulation was not diminished by reserpine and tetrabenazine. These data show that spiperone is not subject to the granular uptake/storage mechanism and suggest that spiperone and its derivatives are specific ligands for dopamine receptors only.
Huguet
F
F
Unité INSERM-U 316, Laboratoire de Biophysique Médicale, Tours, France.
Chalon
S
S
Guilloteau
D
D
Besnard
J C
JC
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D003342:Corpus Striatum / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000378:metabolism*; D004298:Dopamine / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D008024:Ligands; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D013134:Spiperone / Q000493:pharmacokinetics*
D008024:Ligands; D013134:Spiperone; D004298:Dopamine