title: [Nuclear magnetic resonance and iron overload in thalassemia].
abstract: We assessed the iron load content in 36 beta-thalassemia patients by NMR correlating the results with serum ferritin levels. 22 of them were affected by beta-thalassemia major on hyper-transfusional regimen (Group A), 4 by beta-thalassemia intermedia (Group B) and 10 by beta-thalassemia major, who had been previously bone marrow transplanted (Group C). In A and C Groups the liver showed the lowest signal intensity on spin echo images (p less than 0.01; p less than 0.06, respectively). A significant correlation between the summation of signals obtained from all the examined organs and serum ferritin levels was observed by evaluating both all the patients globally (r = 0.78; p less than 0.001) and the A and C Group patients. This correlation was confirmed only in the liver both in all the patients (r = 0.77; p less than 0.001) and in A and C Group patients, when the signals obtained from each organ were evaluated.
authors.affiliation: Istituto di Pediatria Clinica e Preventiva, Università di Bari.
authors.forename: F
authors.initials: F
authors.lastname: Schettini
authors.forename: D
authors.initials: D
authors.lastname: De Mattia
authors.forename: L
authors.initials: L
authors.lastname: Cavallo
authors.forename: V
authors.initials: V
authors.lastname: Sabato
authors.forename: N
authors.initials: N
authors.lastname: Santoro
authors.forename: G C
authors.initials: GC
authors.lastname: Del Vecchio
authors.forename: G
authors.initials: G
authors.lastname: Martinelli
authors.forename: A
authors.initials: A
authors.lastname: Martinelli
authors.forename: P
authors.initials: P
authors.lastname: Di Bartolomeo
authors.forename: G
authors.initials: G
authors.lastname: Di Girolamo
mesh_terms: D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D010179:Pancreas / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D013789:Thalassemia / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy
chemical_list: D005293:Ferritins; D007501:Iron
vernacular_title: Risonanza magnetica nucleare e sovraccarico marziale nella talassemia.