[A case of reflux nephropathy associated with pheochromocytoma].
A 26-year-old female patient complicated with reflux nephropathy and pheochromocytoma is reported. We could not find either intrinsic or extrinsic factor of urinary tract obstruction. The open bilateral renal biopsy was performed at the time of resection of the tumor. The renal biopsy specimen demonstrated minor glomerular change, severe tubular "thyroid-like" appearance and cast formation in the obvious reflux side. Otherwise focal glomerular sclerosis (FGS) lesion was found in less reflux side. In reflux nephropathy, FGS lesion is reported as main cause of progression, but mechanism of FGS lesion is unknown. This case which has both vesicoureteral reflux the high plasma nor-epinephrine concentration was considered to be important to emphasize circulative factor in the pathogenesis of FGS like lesion.
In
H
H
Department of Medicine (II) and Urology, Niigata University Medical School.
Saito
T
T
Nishi
S
S
Maruyama
Y
Y
Takayama
R
R
Sato
H
H
Suzuki
S
S
Ueno
M
M
Gejyo
H
H
Takeda
M
M
D000310:Adrenal Gland Neoplasms / Q000150:complications*; D000328:Adult; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D009638:Norepinephrine / Q000097:blood; D010673:Pheochromocytoma / Q000150:complications*; D014718:Vesico-Ureteral Reflux / Q000150:complications* / Q000175:diagnosis
D009638:Norepinephrine