[The M-receptor stimulation of phosphatidylinositol metabolism in the isolated rabbit heart].
The activating effect of a M-receptor agonist carbachol on phosphatidylinositol metabolism under perfusion of the isolated rabbit heart with 32Pi was shown. An increase of the inclusion of 32P in phosphatidylinositol-4-phosphate and phosphatidylinositol-4-diphosphate was found. Simultaneously there was detected an elevation of the levels of products of hydrolysis of inositol phospholipids--inositol-1,4-diphosphate and inositol-1,4,5-triphosphate. There was noted the blocking action of carbachol on the contractile activity of the heart that manifested itself in a lowering of the systolic pressure in the left ventricle and a slowing of the contraction rate.
Kocherga
V I
VI
Nesterenko
N V
NV
Kurchenko
L K
LK
Afanas'ev
V A
VA
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion / Q000379:methods; D010716:Phosphatidylinositols / Q000378:metabolism*; D010761:Phosphorus Radioisotopes; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000187:drug effects* / Q000502:physiology; D012508:Sarcolemma / Q000187:drug effects / Q000378:metabolism
D010716:Phosphatidylinositols; D010761:Phosphorus Radioisotopes; D011976:Receptors, Muscarinic; D000255:Adenosine Triphosphate; D002217:Carbachol
M-retseptornaia stimuliatsiia obmena fosfatidilinozitidov v izolirovannom serdtse krolika.