title: Regio- and stereoselective enzymatic esterification of glycerol and its derivatives.
abstract: A methodology for regio- and stereoselective preparation of acyl glycerol derivatives is presented. It offers easy access to specific 1,2-, 1,3-diglycerides and triglycerides as well as alkyl glycerol esters, phospholipids and glycolipids. These compounds are prepared by esterification of the corresponding glycerol derivatives such as 2-monoglycerides, alkyl glycerols, glyceryl glycosides, glyceryl phosphate esters, or unsubstituted glycerol. The regio- and stereoselectivity in the esterification is achieved by using fatty acid anhydrides and an enzymatic catalyst, 1,3-specific lipase. NMR methods for determining the regio- and stereoselectivity of esterification are discussed.
authors.affiliation: Procter and Gamble Co., Miami Valley Laboratories, Cincinnati, OH 45239-8707.
authors.forename: A W
authors.initials: AW
authors.lastname: Mazur
authors.forename: G D
authors.initials: GD
authors.lastname: Hiler
authors.forename: S S
authors.initials: SS
authors.lastname: Lee
authors.forename: M P
authors.initials: MP
authors.lastname: Armstrong
authors.forename: J D
authors.initials: JD
authors.lastname: Wendel
mesh_terms: D004951:Esterification; D005990:Glycerol / Q000031:analogs & derivatives / Q000737:chemistry*; D008049:Lipase / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D008049:Lipase; D005990:Glycerol