Effect of antiseptic mouthwashes on some clinical and microbiological findings in the mouths of lymphoma patients receiving cytostatic drugs.
51 patients suffering from Hodgkin's disease or non-Hodgkin's lymphoma participated in this double-blind, cross-over study in which 2 antiseptic mouthwashes were tested for their effects on various periodontal index scores and salivary microbial counts. All patients were receiving combination cytostatic treatment based on methotrexate and doxorubicin. The patients (49 +/- 14 years old, 28 men, 23 women) were allotted at random to 2 groups. One rinsed with a 0.12% chlorhexidine gluconate (CHX) solution, the other with a 0.025% amine-stannous fluoride (AmF + SnF) solution 2x daily for 2 weeks. Both groups then continued rinsing with a 0.05% sodium fluoride (F) solution for 2 weeks, before switching over to AmF + SnF or CHX, respectively. All solutions had been prepared in such a way that they had the same colour and taste. Visible plaque index and gingival bleeding index scores were significantly reduced after periods of rinsing with CHX solution (P less than 0.001) and AmF + SnF solution (P less than 0.05). Microbiological cultivations of saliva specimens revealed significant reductions in mutans streptococci immediately after commencing rinsing, while lactobacilli and yeast counts were not affected.
Meurman
J H
JH
Department of Cariology, University of Helsinki, Finland.
Laine
P
P
Murtomaa
H
H
Lindqvist
C
C
Torkko
H
H
Teerenhovi
L
L
Pyrhönen
S
S
D000588:Amines / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003773:Dental Plaque / Q000517:prevention & control; D003774:Dental Plaque Index; D004311:Double-Blind Method; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D005884:Gingival Hemorrhage / Q000517:prevention & control; D005891:Gingivitis / Q000517:prevention & control; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects / Q000302:isolation & purification; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D010512:Periodontal Index; D012463:Saliva / Q000382:microbiology; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D013295:Streptococcus mutans / Q000187:drug effects / Q000302:isolation & purification; D014002:Tin Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D015003:Yeasts / Q000187:drug effects / Q000302:isolation & purification
D000588:Amines; D009067:Mouthwashes; D014002:Tin Fluorides; D004317:Doxorubicin; D012969:Sodium Fluoride; C010882:chlorhexidine gluconate; D005459:Fluorides; D002710:Chlorhexidine; D008727:Methotrexate