title: Phantom studies and preliminary clinical experience with the BSD 2000.
abstract: The BSD 2000 system is an array of microwave antennas operating in the 60-120 MHz range. It is a four-quadrant regional hyperthermia device with phase control permitting the operator to choose the point of constructive interference. A computer preplanning system is provided. We have compared the computer predictions with measured relative specific absorption rate (SAR) distributions in muscle equivalent phantoms and pig cadaver. The predicted SAR distribution is in qualitative agreement with observation, although differences of approximately 3-5 cm in the location of iso- SAR contours were noted. The longitudinal dependence of relative of distance cephalad to the central plane of the power distribution was measured, and it was found that a length of 15-20 cm was covered by the 50% iso-SAR. SAR measurements in the spinal canal of a pig cadaver showed that, even at resonance frequency, the measured SAR in the cervical spine was small (0.07 of central axis SAR). However, the spinal canal SAR as measured in the central plane of an evenly balanced configuration was 0.6 of the peak SAR. Marked reduction of the spinal canal SAR could be obtained with steering techniques and was in good agreement with the computer preplan. This paper reviews preliminary clinical experience with 17 patients. All but 2 patients were treated with steering techniques to permit partial sparing of normal tissues. The goal of maintaining central tumour temperature at or above 42 degrees C for at least 30 min was maintained in 41 of 67 sessions (61%) and in at least one session for all but 2 patients. Seventy-seven per cent of monitored tumor points attained at least 42 degrees C in patients for whom thermal mapping was performed. Significant cardiovascular stress developed during hyperthermia in two patients. There have been five complete responses and seven partial responses in the 17 patients.
authors.affiliation: Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: R J
authors.initials: RJ
authors.lastname: Myerson
authors.forename: L
authors.initials: L
authors.lastname: Leybovich
authors.forename: B
authors.initials: B
authors.lastname: Emami
authors.forename: P W
authors.initials: PW
authors.lastname: Grigsby
authors.forename: W
authors.initials: W
authors.lastname: Straube
authors.forename: D
authors.initials: D
authors.lastname: Von Gerichten
mesh_terms: D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D008872:Microwaves / Q000627:therapeutic use; D008961:Models, Structural; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000628:therapy*; D013813:Therapy, Computer-Assisted; D014057:Tomography, X-Ray Computed