[Intrauterine and postnatal pneumonia in acquired immunodeficiency of infants].
The autopsy material of 15 children aged from 2 months to 3 years from the zonal group of increased risk of the ecologic pathology, acquired immunodeficiency and viral infections was assessed morphologically and clinically. Decreased number of T-cells (T4, T8), an increase of the level of serum IgA, IgE and immune complexes, HIV-antibodies (4 cases) were found in the patients. The method of the molecular hybridization by means of virus-specific 32P-DNA probes was used. Bronchopneumonia was the cause of death. Severe deficiency of the organs and cells of the immune system, alternative-proliferative lung inflammation, mainly in the form of pneumonitis and alveolitis, were found. The latter differed either individually or as a result of the predominant infectious agent (RNA- or DNA-viruses, pneumocysts, bacterial flora, fungi). Considerable immunity dysfunctions enhanced the intensity of the specific features in pneumonia morphology.
Klembovskiĭ
A I
AI
Muzykantova
V S
VS
Kunitskiĭ
Iu B
IuB
Viduta
O D
OD
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000936:Antigen-Antibody Complex / Q000097:blood; D002675:Child, Preschool; D005315:Fetal Diseases / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007073:Immunoglobulin E / Q000378:metabolism; D007223:Infant; D007231:Infant, Newborn; D007958:Leukocyte Count; D011014:Pneumonia / Q000150:complications / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes; D014777:Virus Diseases / Q000473:pathology
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007073:Immunoglobulin E
Vnutriutrobnye i postnatal'nye pnevmonii v usloviiakh priobretennogo immunodefitsita u deteĭ rannego vozrasta.