Effects of fused-ring antibiotics on metallic corrosion.
The effect on metallic corrosion of antibiotics containing the fused-ring structure of tetracycline (doxycycline and the dihydrate and hydrochloride salts of oxytetracycline) when present in 1% KCl solution was investigated. Corrosion potential and zero resistance ammetry studies were carried out; the effects observed were variable and depended upon the nature of the metal and its surface condition. All three antibiotics appeared to stimulate the corrosion of Vitallium (cobalt-chromium alloy), but corrosion inhibition was found for as-received titanium with all three antibiotics, for abraded titanium with doxycycline and for stainless steel with oxytetracycline dihydrate.
von Fraunhofer
J A
JA
Health Sciences Center, University of Louisville, KY 40292.
Stidham
S H
SH
D003343:Corrosion; D004318:Doxycycline / Q000494:pharmacology; D008422:Materials Testing; D010118:Oxytetracycline / Q000494:pharmacology; D019736:Prostheses and Implants; D013193:Stainless Steel; D013752:Tetracycline / Q000494:pharmacology; D013754:Tetracyclines / Q000494:pharmacology*; D014025:Titanium; D014800:Vitallium
D013754:Tetracyclines; D013193:Stainless Steel; D014800:Vitallium; D014025:Titanium; D013752:Tetracycline; D004318:Doxycycline; D010118:Oxytetracycline