title: Thrombotic microangiopathy and the antiphospholipid antibody syndrome.
abstract: A 23-year-old woman with the antiphospholipid syndrome developed severe thrombocytopenia (14 x 10(9)/l) and microangiopathic hemolytic anemia after plasma exchange. A relation was suspected between rising anticardiolipin level and development of thrombotic microangiopathy. The mechanism responsible may be interference between anticardiolipin antibody, platelet membrane and endothelial cell.
authors.affiliation: Department of Internal Medicine, CHU Sainte Marguerite, Marseille, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Durand
authors.forename: P
authors.initials: P
authors.lastname: Lefevre
authors.forename: G
authors.initials: G
authors.lastname: Kaplanski
authors.forename: J
authors.initials: J
authors.lastname: Soubeyrand
mesh_terms: D000328:Adult; D000743:Anemia, Hemolytic / Q000150:complications*; D000906:Antibodies / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000276:immunology / Q000628:therapy; D002308:Cardiolipins / Q000276:immunology; D005260:Female; D006801:Humans; D008833:Microcirculation; D010951:Plasma Exchange; D013921:Thrombocytopenia / Q000150:complications*
chemical_list: D000906:Antibodies; D002308:Cardiolipins