Myoelectric intestinal disturbances in Escherichia coli endotoxic shock in rats. Involvement of platelet-activating factor.
Administration of BN 52021 (50 mg/kg i.v.), a specific antagonist of platelet-activating factor (PAF), significantly reduced the intestinal myoelectric disturbances induced by E. coli endotoxin injection (50 micrograms/kg i.v.) by 62%. Thus, PAF may be involved in the intestinal motor alterations observed in endotoxic shock. When given in combination with indomethacin (10 mg/kg i.p.), BN 52021 inhibited endotoxic shock intestinal disturbances. Indomethacin alone also reduced PAF induced (25 micrograms/kg i.p.) disruption of migrating myoelectric complexes. Endotoxins may act on intestinal motility via release of endogenous PAF and prostaglandins, the effects of PAF being mediated through the release of prostaglandins.
Pons
L
L
Department of Pharmacology INRA, Toulouse, France.
Droy-Lefaix
M T
MT
Braquet
P
P
Buéno
L
L
D000818:Animals; D004224:Diterpenes; D004386:Duodenum / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D004731:Endotoxins / Q000633:toxicity; D004926:Escherichia coli; D046934:Ginkgolides; D007213:Indomethacin / Q000494:pharmacology; D007583:Jejunum / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000503:physiopathology*
D004224:Diterpenes; D004731:Endotoxins; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; C045856:ginkgolide B; D007213:Indomethacin