Aluminium phosphide poisoning: haemodynamic observations.
Haemodynamic measurements were made on 25 patients with aluminium phosphide poisoning. There was severe hypotension (mean arterial pressure 62.7 +/- 19.3 mmHg) and reduction in cardiac output (2.13 +/- 0.9 lit/min/m2). However, the systemic vascular resistance was only moderately elevated (2050 +/- 732 dynes/m2). The right atrial pressure was increased but the pulmonary artery and pulmonary capillary wedge pressures were normal, even in patients with pulmonary oedema. Thirteen patients (52%) who died had a lower cardiac output (p less than 0.05). Saline infusion significantly improved haemodynamics in some patients. Its judicious use early in the course of treatment may be beneficial.
Kalra
G S
GS
Department of Cardiology, Postgraduate Institute of Medical Education & Research, Chandigarh.
Anand
I S
IS
Jit
I
I
Bushnurmath
B
B
Wahi
P L
PL
D000293:Adolescent; D000328:Adult; D017607:Aluminum Compounds; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D010720:Phosphines / Q000506:poisoning*; D011041:Poisoning / Q000503:physiopathology; D011654:Pulmonary Edema / Q000139:chemically induced
D017607:Aluminum Compounds; D010720:Phosphines; C001864:aluminum phosphide