Sensitivity of human melanoma cells in vitro to retinoic acid incorporated in liposomes.
The ability of retinoic acid to inhibit the growth of three human melanoma cell lines (MEW18, MEW22, MEW81) was studied in culture. The exposure of the cell lines to different concentrations of RA resulted in an inhibition of the cell growth, dependent on the quantity of RA in the medium. Effects on cell growth of MEW81 cells by RA, introduced into the medium in DMSO solution or incorporated in MLV, were also compared. The inhibitory potencies of the drug in two forms were similar, however, the inhibitory effects of RA in MLV were more stable than the effects of RA dissolved in DMSO.
Tarasiuk
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Institute for Drug Research and Control, Warsaw.
D002455:Cell Division / Q000187:drug effects; D004121:Dimethyl Sulfoxide; D004337:Drug Carriers; D006801:Humans; D008081:Liposomes; D008545:Melanoma / Q000188:drug therapy*; D014212:Tretinoin / Q000008:administration & dosage*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004337:Drug Carriers; D008081:Liposomes; D014212:Tretinoin; D004121:Dimethyl Sulfoxide