[The cardioprotective action of quercetin in experimental occlusion and reperfusion of the coronary artery in dogs].
In experimental myocardial infarction in dogs caused by 60-minute occlusion of the coronary artery with the subsequent 24-hour reperfusion, the administration of quercetin solution (50 mg/kg) was found to improve the contractile function of the left ventricular myocardium, to decrease the incidence of heart rate and conductivity disorders, to contribute to limitation of the ischemic damage area, to exert the protective effect on the ultrastructure of the coronary arteries that can promote the preservation of the vessels' integrity, the improvement of the coronary circulation and the prevention of intravascular thrombus formation.
Kolchin
Iu N
IuN
Maksiutina
N P
NP
Balanda
P P
PP
Luĭk
A I
AI
Bulakh
V N
VN
Moĭbenko
A A
AA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D006328:Cardiac Catheterization; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008854:Microscopy, Electron; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*; D009206:Myocardium / Q000648:ultrastructure; D011794:Quercetin / Q000627:therapeutic use*; D013997:Time Factors
D011794:Quercetin
Kardioprotektornoe deĭstvie kvertsetina pri éksperimental'noĭ okkliuzii i reperfuzii koronarnoĭ arterii u sobak.