The sojourn time and its use in pharmacology.
A short review on some pharmacokinetic parameters (mean residence time, sojourn time, transit time) is given in relation to compartmental models and some examples and application are discussed. In particular the use of the sojourn time is suggested because this parameter can give useful informations when comparing the pharmacokinetics of different drugs or in pharmacodynamics.
Segre
G
G
Instituto di Farmacologia, Laboratorio di Farmacocinetica, Università di Siena, Italy.
Urso
R
R
D001398:Aztreonam / Q000493:pharmacokinetics; D001794:Blood Pressure / Q000187:drug effects; D005839:Gentamicins / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D008954:Models, Biological; D009638:Norepinephrine / Q000493:pharmacokinetics / Q000494:pharmacology; D010599:Pharmacokinetics
D005839:Gentamicins; D001398:Aztreonam; D009638:Norepinephrine