[Mechanisms of emergency adaptation of the erythron system to hypoxia in rats receiving cavinton].
The authors conducted comparative study of the red cell 2,3-biphosphoglycerate concentration, serum erythropoietin titer, acid-base equilibrium, reticulocyte count, and lactic acid concentration in rats after 3, 24, and 48 hours exposure to hypobaric hypoxia and Cavinton administration under the same conditions. It was established that Cavinton accelerates the emergency mechanisms of the erythron system adaptation through increases of red cell production. Besides, the adaptational role of 2,3-biphosphoglycerate increases due to normalization of blood pH under the effect of Cavinton in the first 3 hours of hypoxia.
Morshchakova
E F
EF
Krokhotina
L V
LV
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D004630:Emergencies; D004912:Erythrocytes / Q000502:physiology*; D000860:Hypoxia / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D014748:Vinca Alkaloids / Q000627:therapeutic use*
D014748:Vinca Alkaloids; C013983:vinpocetine
Mekhanizmy ékstrennoĭ adaptatsii sistemy éritron k gipoksii u krys, poluchavshikh kavinton.