Evaluation of antibody-bearing liposomal amphotericin B in the treatment of systemic candidiasis in a neutropenic murine model.
The efficacy of liposomal amphotericin B bearing anticandidal antibodies (LAMB-Ab) was investigated in the treatment of systemic candidiasis in a murine model made neutropenic by an intraperitoneal injection of cyclophosphamide. Treatment with a single dose (0.6 mg amphotericin B kg-1 body weight) of LAMB-Ab resulted in an improved survival of neutropenic mice infected with Candida albicans compared to neutropenic mice treated with identical doses of liposomal amphotericin B or free amphotericin B.
Belay
T
T
Department of Botany and Plant Pathology, Michigan State University, East Lansing 48824.
Hospenthal
D R
DR
Rogers
A L
AL
Patterson
M J
MJ
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000908:Antibodies, Fungal / Q000008:administration & dosage*; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000150:complications / Q000628:therapy*; D004195:Disease Models, Animal; D008081:Liposomes; D051379:Mice; D009503:Neutropenia / Q000150:complications*
D000908:Antibodies, Fungal; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B