Changes in whole brain membranes of rats following pre- and post-natal exposure to ethanol.
The chronic effects of ethanol on the fatty acid composition of rats that have been exposed to ethanol in utero were examined. Ten female Wistar rats were fed a nutritionally adequate liquid diet for 3 weeks before mating, throughout gestation and until the offspring reached the 10th or 20th post-natal day. Whole brain lipid changes were examined at these 2 time points. On day 10, a decrease in 18:1 lipid content was found, indicating tolerance development. However, by day 20 an increase in polyunsaturated fatty acid content (20:4) was detected, indicating that ethanol may be causing an increase in membrane fluidity. Although these results are contrary to those found in adult rats following chronic ethanol administration, it seems likely that, in the immature animal, the brain is still undergoing rapid development and therefore may be affected differentially by ethanol.
Duffy
O
O
Department of Pharmacology, University College Galway, Ireland.
Menez
J F
JF
Floch
H H
HH
Leonard
B E
BE
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000473:pathology*; D002554:Cerebrosides / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000473:pathology*; D008560:Membrane Fluidity / Q000502:physiology*; D008563:Membrane Lipids / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013433:Sulfoglycosphingolipids / Q000378:metabolism; D013570:Synaptic Membranes / Q000473:pathology*
D002554:Cerebrosides; D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids; D013433:Sulfoglycosphingolipids; D010758:Phosphorus; D002784:Cholesterol