[The effect of different protein diets on longevity and various biochemical parameters of aged rats].
In this work 23 month old rats were fed for 200 days with different protein diets (NT-diet: 19% protein, 72% of animal origin and LP-diet: 8.8% protein exclusively of vegetable origin). Some metabolic parameters and lifespan (on the base of a 50% death-rate) were determined. The relations of the liver free amino acids glycine + alanine and tyrosine + phenylalanine + branched chain amino acids and the ratio of phenylalanine/tyrosine were determined to be higher in the LP-group. Phenylalanine in liver and urea concentrations in liver and serum were lower in the LP-group. Furthermore the dopamine or serotonin levels were significantly lower in lateral and medial or lateral regions of the hypothalamus respectively in LP-diet fed rats. The norepinephrine content was not modified by the diets. The median lifespan of 23 month old rats was higher by 24% following LP-treatment. These results suggest that the protein component (amino acids) of different diets may modify metabolic parameters and lifespan of animals by mechanisms in which the central regulation may be involved.
Medovar BJa
Institut für Gerontologie, AMW, UdSSR, Kiev.
Petzke
K J
KJ
Semesko
T G
TG
Albrecht
V
V
Grigorov JuG
D000375:Aging / Q000502:physiology; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004044:Dietary Proteins / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008136:Longevity / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism
D000596:Amino Acids; D004044:Dietary Proteins; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine
Zur Wirkung unterschiedlicher Proteindiäten auf Lebensdauer und ausgewählte biochemische Parameter von alten Ratten.