title: Prolonged (24-hour) manometric recording of rectal contractile activity in patients with slow transient constipation.
abstract: A periodic motor activity, named the rectal motor complex, has been recently described in the healthy human rectum. We studied the rectal contractile activity for 24 h by a low compliance manometric system in a group of 10 women with slow transit constipation. Analysis of the 24-hour manometric recordings showed that these subjects: (1) had overall scarce rectal motility; (2) display few rectal motor complexes (average, 3.3 +/- 1.3/subject/24 h) which are irregularly distributed over time, and (3) respond weakly to ingestion of a standard meal (average duration of the motor response 19 +/- 6 min). The observations suggest that an underlying neuropathic process may be involved in the pathogenesis of the impaired rectal motility in patients with slow transit constipation.
authors.affiliation: Laboratorio di Motilità Intestinale, Università di Perugia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bassotti
authors.forename: C
authors.initials: C
authors.lastname: Betti
authors.forename: M A
authors.initials: MA
authors.lastname: Pelli
authors.forename: A
authors.initials: A
authors.lastname: Morelli
mesh_terms: D000328:Adult; D003248:Constipation / Q000503:physiopathology*; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D008365:Manometry; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D012007:Rectum / Q000503:physiopathology*; D012189:Retrospective Studies