Immunological upgrading with combined immunotherapy and chemotherapy in a lepromatous leprosy patient: a case report.
Immunotherapy with Mycobacterium w was given, in addition to standard multidrug therapy (MDT) to a lepromatous leprosy (LL) patient with a bacteriological index (BI) of 6. After 15 months of treatment this patient attained bacteriological negativity and clinical inactivity. Histopathologically the patient upgraded to borderline-tuberculoid at 12 months, and at 15 months showed features of nonspecific infiltration in the dermis. The rapid immunological upgrading seen in the patient is highlighted in this paper.
Zaheer
S A
SA
National Institute of Immunology, New Delhi, India.
Suresh
N R
NR
Kar
H K
HK
Sharma
A K
AK
Mukherjee
A
A
Mukherjee
R
R
Talwar
G P
GP
D001428:Bacterial Vaccines / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D006801:Humans; D007916:Lepromin / Q000276:immunology; D007917:Leprostatic Agents / Q000008:administration & dosage*; D015440:Leprosy, Lepromatous / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000276:immunology
D001428:Bacterial Vaccines; D007917:Leprostatic Agents; C060596:anti-leprosy vaccine; D007916:Lepromin