Insulin and insulin-like growth factor I exert different effects on plasminogen activator production or cell growth in the ovine thyroid cell line OVNIS.
Insulin and Insulin-like Growth Factor I (IGF-I) are evaluated for their capacity to affect cell proliferation and plasminogen activator (PA) activity production in an ovine thyroid cell line OVNIS. Insulin at physiological and supraphysiological doses induces cell proliferation and increases PA activity. IGF-I, which is also clearly mitogenic for these cells, surprisingly does not modulate PA activity. The results indicate that the growth promoting effect is mediated through the insulin and IGF-I receptors whereas PA activity is solely regulated via the insulin receptors.
Degryse
B
B
Laboratoire de Biochimie Médicale, Faculté de Médecine, Marseille, France.
Maisonobe
F
F
Hovsépian
S
S
Fayet
G
G
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D010960:Plasminogen Activators / Q000096:biosynthesis*; D012756:Sheep; D013961:Thyroid Gland / Q000502:physiology*; D013997:Time Factors
D007328:Insulin; D007334:Insulin-Like Growth Factor I; D010960:Plasminogen Activators