title: Castration reduces potassium-stimulated norepinephrine release from superfused olfactory bulbs of male rats.
abstract: In order to investigate the possible relationship among the olfactory bulb (OB), norepinephrine (NE) and gonadal steroids, we measured NE release from superfused anterior and posterior OB in intact and castrated male rats (Expt. I) as well as in castrated male rats implanted with either empty or testosterone filled silastic capsules (Expt. II). Both basal and potassium (K+ 30 mM)-stimulated release of NE was greater in posterior compared to anterior OB. All groups were responsive to the K+ stimuli showing increases in NE release. The degree of K(+)-stimulated release was significantly greater in intact compared to that of castrated rats. No differences in K(+)-stimulated release were observed between castrated and castrated plus testosterone-treated groups. These results demonstrate that castration of male rats significantly reduces OB noradrenergic responsiveness to K+ stimulation, an effect which was not restored following administration of silastic capsules containing testosterone.
authors.affiliation: Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
authors.forename: X B
authors.initials: XB
authors.lastname: Guan
authors.forename: D
authors.initials: D
authors.lastname: Dluzen
mesh_terms: D000818:Animals; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D009919:Orchiectomy; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D011188:Potassium; D009638:Norepinephrine