[Experimental study on combined treatment in smoke inhalation injury].
Forty-two healthy dogs were randomly divided equally into a control group (CG) and a treated group (TG). All were inflicted with severe smoke inhalation injury and pulmonary was demonstrated. The dogs in TG were treated with injection of shenmai zhusheye, ketoprofen, anisodamine, sodium aesculin, hydrocortisone succinate, vitamin C and E, penicillin, amikacin, oxygen inhalation and airway suctioning after injury. The results showed that the increase in extravascular lung water volume, lung edema shadow in x-ray films, elevation of lung vascular resistance, carbonemia, hypoxemia, respiratory alkalosis, metabolic acidosis, dyspnea, dry and moist rales of the lungs, reduction of tidal volume, etc, were markedly improved in TG as compared with that of CG. It indicated that the pulmonary edema and lung dysfunction was markedly ameliorated in TG. The mortality was 19.1% in TG, which was significant lower than that of CG which was 47.6%.
Jiang
K Y
KY
Burn Institute, Southwestern Hospital, Third Military Medical College, Chongging.
D000818:Animals; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D011654:Pulmonary Edema / Q000188:drug therapy / Q000209:etiology; D015208:Smoke Inhalation Injury / Q000150:complications / Q000188:drug therapy*; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine