Rapid accumulation of plasma acid-stable trypsin inhibitor in experimental acute renal injury.
Acid-stable trypsin inhibitor (ASTI) activity was measured during experimental acute renal tubular dysfunction and glomerulonephritis in rats. A marked elevation of ASTI activity occurred at a very early stage of acute renal tubular damage, and the changes were observed prior to histological abnormalities or elevation of blood creatinine. No alteration in ASTI activity was observed at an early stage of experimental glomerulonephritis. The data obtained confirm that ASTI is excreted through the renal tubules and that the plasma ASTI concentration is very sensitive to renal tubular dysfunction.
Maruyama
M
M
Department of Physiology, Miyazaki Medical College, Kihara, Japan.
Yoshida
E
E
Sugiki
M
M
Mihara
H
H
Sumi
H
H
Sakai
R
R
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D003637:DEAE-Dextran / Q000494:pharmacology; D005921:Glomerulonephritis / Q000139:chemically induced / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism / Q000473:pathology; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology; D007684:Kidney Tubules / Q000378:metabolism / Q000473:pathology; D008026:Ligation; D008297:Male; D008657:Metabolic Clearance Rate; D011507:Proteinuria; D051381:Rats; D011919:Rats, Inbred Strains; D012077:Renal Artery; D014361:Trypsin Inhibitors / Q000378:metabolism*
D001798:Blood Proteins; D014361:Trypsin Inhibitors; D003637:DEAE-Dextran; D003404:Creatinine