A comparison of the effect of synthetic and naturally occurring surfactants on the solubility and absorption of clofazimine (B 663).
All simple micellar systems investigated, containing both naturally occurring and synthetic surfactants, enhanced the solubility of clofazimine. The incorporation of fatty acid to form mixed micelles, brought about a further enhancement in drug solubility in the case of naturally occurring surfactants, in contrast, with synthetic surfactants this enhancement decreased. The most effective absorption promoter was a synthetic surfactant: fatty acid mixed micellar system. The results indicate an optimum surfactant: fatty acid ratio at which the solubility and membrane effects of the surfactant system are balanced.
O'Driscoll
C M
CM
University of Dublin, Dept. of Pharmaceutics, School of Pharmacy, Trinity College, Ireland.
O'Reilly
J R
JR
Corrigan
O I
OI
D000042:Absorption / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002991:Clofazimine / Q000737:chemistry*; D008823:Micelles; D010539:Permeability; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013501:Surface-Active Agents / Q000737:chemistry*
D008823:Micelles; D013501:Surface-Active Agents; D002991:Clofazimine