title: [Effect of the methods of sterilization on the quality of nutrient media and on the level of antibiotic production].
abstract: It was shown that conditions for heat sterilization of nutrient media for biosynthesis of antibiotics had an impact on their biochemical composition and activity of a fermentation broth in production of penicillin and erythromycin. The temperature of 120 degrees C and the time of 25 minutes proved to be optimal for sterilization of the media in regard to both preservation of their biochemical composition and providing of the maximum antibiotic productivity on the one hand and maintenance of the sterility during the fermentation process on the other hand.
authors.forename: G L
authors.initials: GL
authors.lastname: Motina
authors.forename: N M
authors.initials: NM
authors.lastname: Kalinina
authors.forename: T M
authors.initials: TM
authors.lastname: Tarasova
authors.forename: T E
authors.initials: TE
authors.lastname: Bryzgalova
authors.forename: A D
authors.initials: AD
authors.lastname: Nekliudov
authors.forename: N I
authors.initials: NI
authors.lastname: Mal'tsev
authors.forename: L M
authors.initials: LM
authors.lastname: Lur'e
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology; D002241:Carbohydrates / Q000008:administration & dosage / Q000494:pharmacology; D003470:Culture Media / Q000592:standards*; D004917:Erythromycin / Q000096:biosynthesis*; D006358:Hot Temperature; D066298:In Vitro Techniques; D007218:Industrial Microbiology / Q000379:methods* / Q000592:standards; D009584:Nitrogen / Q000008:administration & dosage / Q000494:pharmacology; D010406:Penicillins / Q000096:biosynthesis*; D010407:Penicillium / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D016930:Saccharopolyspora / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D013242:Sterilization / Q000379:methods*; D014586:USSR
chemical_list: D000596:Amino Acids; D002241:Carbohydrates; D003470:Culture Media; D010406:Penicillins; D004917:Erythromycin; D009584:Nitrogen
vernacular_title: Vliianie sposobov sterilizatsii na kachestvo pitatel'nykh sred i na uroven' obrazovaniia antibiotikov.