[Effect of protamine on the composition of blood lipoproteins at various periods of hypercholesterolemia in rabbits].
Protamine has been studied for its effect on changes in the protein-lipid composition of main fractions of blood lipoproteins in different periods (1- and 7-months) of hypercholesterolemia in rabbits. Daily introduction of protamine to intact animals for 30 days did not change the studied parameters. Results of analysis of the protamine action against the background of the 1-month hypercholesterolemia testify to an increase of the protein and cholesterin concentration in apoB-containing lipoproteins. A moderate increase of the cholesterin concentration in the HDL composition has been observed, the protein concentration remaining at high level. The atherogenic diet for 7 month has induced in animals subjected to its dyslipoproteinemia and atherosclerosis of vessels. Under these conditions protamine has inhibited "proatherogenic" alterations in the composition of lipoproteins. The concentration of protein, cholesterin and triglycerides in the apoB-containing fractions decreased and the concentration of total cholesterin and triglycerides in the blood serum fell considerably.
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D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control; D001798:Blood Proteins / Q000378:metabolism; D004036:Diet, Atherogenic; D006937:Hypercholesterolemia / Q000097:blood*; D008074:Lipoproteins / Q000097:blood* / Q000187:drug effects; D011479:Protamines / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D001798:Blood Proteins; D008074:Lipoproteins; D011479:Protamines; D014280:Triglycerides
Diia protaminu na sklad lipoproteïniv krovi u rizni periody giperkholesterynemiï u kroliv.