Urinary levels of interleukin-6 and disease activity in patients with IgA nephropathy.
We studied, using ELISA, 27 patients with IgA nephropathy to determine if levels of urinary interleukin-6 (IL-6) might reflect the disease activity. The levels of urinary IL-6 in patients with the advanced stage were significantly higher than those in patients with the mild stage of the disease or in healthy adults. The results showed a significant correlation between the levels of urinary IL-6 and the disease activity, i.e., levels of urinary cast and urinary protein. It was thus suggested that the measurement of urinary IL-6 is useful in evaluating the degree of glomerular injuries and/or prognosis in patients with IgA nephropathy.
Tomino
Y
Y
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Funabiki
K
K
Ohmuro
H
H
Shimizu
M
M
Yokoyama
K
K
Shirato
I
I
Shirai
T
T
Takahashi
M
M
Koide
H
H
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000652:urine*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000652:urine*; D007678:Kidney Glomerulus / Q000737:chemistry; D008297:Male
D015850:Interleukin-6