Interleukin-6 levels in the cerebrospinal fluid of patients with multiple sclerosis.
We developed the competitive enzyme-linked immunosorbent assay for interleukin-6 (IL-6). The detection limit was 30 pg per ml. Using this method, we examined the IL-6 levels in the cerebrospinal fluid of 10 patients with multiple sclerosis (MS) and 12 age-matched normal controls. IL-6 was detected in 6 out of 10 patients with MS. There was no significant correlation between the IL-6 levels and other parameters, including IgG, IgG index, cell counts, total protein and albumin in the CSF. Our results suggest that IL-6 detected in the MS-CSF may have no correlation to the immunological processes.
Araga
S
S
Division of Neurology, Faculty of Medicine, Tottori University, Yonago.
Takai
H
H
Takahashi
K
K
D000328:Adult; D000418:Albumins / Q000134:cerebrospinal fluid; D001681:Biological Assay; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D015850:Interleukin-6 / Q000134:cerebrospinal fluid*; D008297:Male; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid*; D012044:Regression Analysis
D000418:Albumins; D002556:Cerebrospinal Fluid Proteins; D007074:Immunoglobulin G; D015850:Interleukin-6