Effect of inactivated viral vaccines (human) on frequency of micronuclei in bone marrow erythrocytes of mice.
Cytogenetic effects of the two inactivated viral vaccines (polio and antirabies) were studied in adult male mice by the micronucleus test. Polio salk vaccine did not induce micronuclei formation at both human (0.5 ml) and 1/5th human doses. Antirabies vaccine induced micronuclei in poly and total erythrocytes only at human dose of 2 ml. Beta-propiolactone (BPL) induced micronuclei at higher dose of 5.7 mg, but not at 0.57 mg (approximate concentration present in 2 ml of rabies vaccine). The P/N ratio was not affected in vaccinated and BPL inoculated animals. Antirabies vaccine induced micronuclei percentage was more than the BPL value.
Rao
L V
LV
Department of Microbiology, Nizam College, Osmania University, Hyderabad, India.
Polasa
H
H
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D004912:Erythrocytes / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D011054:Poliovirus Vaccine, Inactivated / Q000494:pharmacology*; D011420:Propiolactone / Q000494:pharmacology; D011819:Rabies Vaccines / Q000494:pharmacology*; D015164:Vaccines, Inactivated / Q000494:pharmacology
D011054:Poliovirus Vaccine, Inactivated; D011819:Rabies Vaccines; D015164:Vaccines, Inactivated; D011420:Propiolactone