[A study on the relationship between histamine receptors and bronchial hyperresponsiveness in asthma].
We measured the bronchial response to histamine in 26 allergic asthmatics and 17 healthy subjects before and after the bronchial pretreatment with selective H2-receptor antagonist ranitidine. We also investigated the results of the new H1-receptor antagonist terfenadine on the prevention and treatment of asthma. Selective H1-receptor stimulation with histamine (pretreated with 18.5mg ranitidine) failed to enhance the effect of histamine in asthma group (P greater than 0.05), whereas it enhanced the histamine response obviously in healthy group (P less than 0.001). We conclude that: 1. BHR to histamine in allergic asthma is related to a functional depression of H2 receptors in airways; 2. terfenadine is useful in the prevention and treatment of asthma.
Wang
S Z
SZ
Department of Respiratory Medicine, Changzheng Hospital, Shanghai.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000494:pharmacology* / Q000627:therapeutic use; D011969:Receptors, Histamine H1 / Q000187:drug effects; D011970:Receptors, Histamine H2 / Q000187:drug effects; D016593:Terfenadine / Q000494:pharmacology* / Q000627:therapeutic use
D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D016593:Terfenadine; D011899:Ranitidine