[The interaction of humoral factors of the blood serum and erythrocytes in regulating immunogenesis in vibration-induced lesions].
Infusion of light red cells of rats subjected to the effect of vibration (RSEV) or red cells incubated with RSEV blood serum inhibits in allogeneic recipients the development of the humoral immune response (HIR) induced by ram red cells (RRC); infusion of heavy red cells intensifies somewhat this process. Retinol acetate infusion intensifies the development of the HIR in RSEV and induces the secretion of the factor causing the appearance of immunostimulating properties is the red cells of intact rats by the splenocytes. The heavy fraction of the red cells of these animals possesses marked immunostimulating properties, while the light fraction possesses immunosuppressive properties. Tocopherol acetate infusion intensifies essentially the development of the humoral immune response in RSEV and blocks excretion into the blood of a factor which induces the appearance of immunosuppressive properties in the red cells of intact rats. The heavy red cell fraction in RSEV who received tocopherol acetate possesses mild immunostimulating properties, while the light fraction does not induce a immunomodulation effect.
Prokopenko
L G
LG
Siplivaia
L E
LE
Iakovleva
E A
EA
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D002458:Cell Fractionation; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology*; D007114:Immunization; D051381:Rats; D011919:Rats, Inbred Strains; D012397:Rosette Formation; D014732:Vibration / Q000009:adverse effects*
D007106:Immune Sera
Vzaimodeĭstvie gumoral'nykh faktorov syvorotki krovi i éritrotsitov v reguliatsii immunogeneza pri vibratsionnom porazhenii.