[Central neural mechanism underlying pressor response to excitation of locus coeruleus in rats].
Experiments were done on urethane anesthetized, tubocurarine immobilized and artificially ventilated rats and the following results were observed: (1) Injection of sodium L-glutamate (Glu) into locus coeruleus (LC) could evoke a pressor response, but heart rate was not significantly affected; while depressor and bradycardia effects were observed when injecting into closely adjacent areas. (2) The LC-pressor response decreased after a brain transection caudal to nucleus paraventricularis was made but remained unchanged if the transection was rostral to the nucleus; The LC-pressor response could also be attenuated by preinjection of phentolamine propranolol or atropine respectively into the rostral ventrolateral medulla (RVL). The above results suggest that LC-pressor response is not only mediated by RVL, but also by nucleus paraventricularis.
Zhou
C J
CJ
Department of Physiology, Beijing Medical University.
Zou
X
X
Ku
Y H
YH
D000818:Animals; D001794:Blood Pressure; D006339:Heart Rate; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology; D008845:Microinjections; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology; D010646:Phentolamine / Q000494:pharmacology; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D012970:Sodium Glutamate / Q000494:pharmacology*
D012970:Sodium Glutamate; D010646:Phentolamine