Cell surface carbohydrates in cell adhesion.
Carbohydrates are ubiquitous constituents of cell surfaces, and possess many characteristics that make them ideal candidates for recognition molecules. In many systems where cell adhesion plays a critical role, carbohydrate binding proteins have been shown to bind to cell surface carbohydrates and participate in cell-cell interactions. Such systems include fertilization, development, pathogen-host recognition and inflammation. In particular the recent discovery of the LEC-CAMs and their importance in leukocyte biology has refocused attention on lectin-mediated cell adhesion. The LEC-CAMs offer good targets for the development of therapeutics based on carbohydrate structures.
Brandley
B K
BK
Glycomed, Inc., Alameda, CA 94501.
D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000502:physiology* / Q000627:therapeutic use; D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D005306:Fertilization; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D008969:Molecular Sequence Data; D014780:Viruses / Q000378:metabolism
D002241:Carbohydrates; D015815:Cell Adhesion Molecules; D037102:Lectins