[Dystrophin expression in skeletal muscles in endurance-trained hypo-hyperthyroid and growth-hormone treated rats].
The aim of this study was to determine the effect of chronic muscular exercise, thyroid status and growth hormone administration on skeletal muscle dystrophin expression. Relative abundance of dystrophin (quantity in arbitrary units/50 micrograms of protein) was measured by immunoblotting and densimometry. Our results indicate that relative abundance of dystrophin in slow-or fast-twicht muscle was not modified by chronic muscular exercise (5 weeks), thyroxine administration (4 weeks), antithyroid drug treatment (6 weeks) or growth hormone administration (6 weeks).
Ferry
A
A
Laboratoire de Physiologie des Adaptations, UFR Cochin Port-Royal, Université Paris V, France.
Wahrmann
J P
JP
Brussee
V
V
Kahn
A
A
Rieu
M
M
D000185:Actinin / Q000032:analysis; D000199:Actins / Q000032:analysis; D000818:Animals; D003720:Densitometry; D016189:Dystrophin / Q000032:analysis*; D013006:Growth Hormone / Q000494:pharmacology*; D015151:Immunoblotting; D008297:Male; D009132:Muscles / Q000737:chemistry*; D010805:Physical Conditioning, Animal; D011441:Propylthiouracil / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000494:pharmacology*
D000199:Actins; D016189:Dystrophin; D000185:Actinin; D011441:Propylthiouracil; D013006:Growth Hormone; D013974:Thyroxine
Expression de la dystrophine dans le muscle squelettique du rat entraîné en endurance, hypo-hyperthyroïdien, et traité par l'hormone de croissance.