title: The efficacy of norfloxacin in the treatment of urinary tract infections in Tikure Anbessa Hospital, Addis Ababa, Ethiopia.
abstract: The efficacy of norfloxacin 400 mg every 12 hours for 7 days was prospectively and openly studied among patients with urinary tract infection. Enrolled were 30 patients based on inclusion and exclusion criteria. 23 patients completed the study and were evaluated for efficacy and tolerability with urinary infections defined as a bacterial count of at least 10(5) bacterial per ml of urine. Follow-up urine cultures at 14-21 days and 4-6 weeks post-treatment were done. 21 of 23 were cured and this was a cure rate of 91%. There were no clinical adverse effects which necessitated cessation of treatment. In vitro test studies were carried out to compare the activity of norfloxacin with commonly used antimicrobials as well as to observe its activity against other organisms which are not normally urinary pathogens. In this aspect of the study, norfloxacin was found to be superior to eleven other antimicrobials with which it was compared. This study showed that drug is very active against urinary and enteric pathogens.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Addis Ababa University, Ethiopia.
authors.forename: B
authors.initials: B
authors.lastname: Mengesha
mesh_terms: D000328:Adult; D000368:Aged; D005002:Ethiopia; D005260:Female; D006786:Hospitals, Urban; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009643:Norfloxacin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology / Q000652:urine
chemical_list: D009643:Norfloxacin