title: Long-term chemical carcinogenesis experiments for identifying potential human cancer hazards: collective database of the National Cancer Institute and National Toxicology Program (1976-1991).
abstract: The carcinogenicity database used for this paper originated in the late 1960s by the National Cancer Institute (NCI) and since 1978 has been continued and made more comprehensive by the National Toxicology Program (NTP). The extensive files contain, among other sets of information, detailed pathology data on more than 400 long-term (most often 24-month) chemical carcinogenesis studies, comprising nearly 1600 individual experiments having at least 10 million tissue sections that have been evaluated for toxicity and carcinogenicity.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
authors.forename: J
authors.initials: J
authors.lastname: Huff
authors.forename: J
authors.initials: J
authors.lastname: Haseman
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity; D016208:Databases, Factual; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests; D009316:National Institutes of Health (U.S.); D009374:Neoplasms, Experimental / Q000139:chemically induced; D009928:Organ Specificity; D051381:Rats; D011916:Rats, Inbred F344; D012307:Risk Factors; D012737:Sex Factors; D013045:Species Specificity; D014116:Toxicology; D014481:United States
chemical_list: D002273:Carcinogens