Thymic and suprarenalian response of Wistar rats following the administration of the humoral thymic factor (Leucotrofina) and of the cytostatic cyclophosphamide.
Leucotrofina administration in Wistar rats induced in thymus an increase of total protein content and of protein synthesis from 14C-leucine, simultaneously with a raise in the AlAT activity. Adrenal glands were not affected. Leucotrofina administration on the background of Cyclophosphamide induced modifications restored at normal values some of the thymic parameters (total protein content and RNA content) but the ascorbic acid content in the adrenals remained lowered.
Giurgea
R
R
Institute of Biological Research and Oncological Institute, Cluj-Napoca, Romania.
Roşioru
C
C
Coprean
D
D
Uray
Z
Z
D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013949:Thymus Extracts / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects*
D013949:Thymus Extracts; C024817:leukotrophin; D003520:Cyclophosphamide