title: Effect of vitamin E-deficiency on the activity of some lysosomal and non-lysosomal proteases in rabbit muscles.
abstract: The activity of different cathepsins and neutral proteinases was measured in normal and vitamin E-deficient rabbit muscles using specific substrates. Among the changes of enzyme activities in dystrophy caused by vitamin E-deficiency the increase in the activity of cathepsin B is the most striking. The activity of cathepsin H, both in the fast and slow muscles and that of MMP-ase in the slow muscle remains practically unchanged. Activities of other proteases significantly increase. The change in the activity of proteolytic enzymes in striated muscle of vitamin E-deficient rabbits seems to be selective. As a rule the increase in the activity is higher in fast than in slow muscles.
authors.affiliation: 2nd Institute of Biochemistry, Semmelweis University Medical School, Budapest, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Katona
authors.forename: V
authors.initials: V
authors.lastname: Székessy-Hermann
authors.forename: F
authors.initials: F
authors.lastname: Guba
authors.forename: I
authors.initials: I
authors.lastname: Sohár
mesh_terms: D000818:Animals; D002401:Cathepsin B / Q000378:metabolism*; D056655:Cathepsin H; D002403:Cathepsins / Q000378:metabolism; D003546:Cysteine Endopeptidases; D004591:Electrophoresis, Polyacrylamide Gel; D010450:Endopeptidases / Q000378:metabolism*; D009132:Muscles / Q000201:enzymology*; D009137:Muscular Dystrophy, Animal / Q000201:enzymology / Q000209:etiology; D011817:Rabbits; D013223:Statistics as Topic; D014811:Vitamin E Deficiency / Q000201:enzymology*
chemical_list: D002403:Cathepsins; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; D056655:Cathepsin H