title: [Antimicrobial sensitivity of 402 strains of Neisseria gonorrhoeae isolated in 7 Spanish cities].
abstract: To study N. gonorrhoeae resistance in Spain. We evaluate 402 strains consecutively isolated in 7 Spanish cities (Barcelona, Bilbao, Madrid, Murcia, Seville, Valencia and Valladolid). The MIC to 9 antimicrobial agents was determined by agar-dilution (DST) method. We found a high incidence (15.7%) of penicillinase producer strains (NGPP). Most (53.3%) of all non-NGPP strains showed reduced sensitivity to penicillin and 1.5% of the strains had chromosomally mediated resistance. All NGPP strains and 90% of non-NGPP strains showed reduced sensitivity to tetracycline (MIC greater than 0.23 mg/l). We did not found any strain with high-level tetracycline resistance. MIC90 for the other drugs tested were: erythromycin, 0.125 mg/l; spectinomycin, 16 mg/l; cefoxitin, 2 mg/l; cefuroxime 0.06 mg/l; ceftriaxone 0.0037 mg/l; ofloxacin 0.06 mg/l and ciprofloxacin, 0.0018 mg/l. NGPP are very prevalent in Spain. Most of these strains had chromosomally mediated resistance to penicillin and tetracycline. We did not found resistance to other antimicrobial agents.
authors.affiliation: Departamento de Microbiología, Facultad de Medicina de Sevilla.
authors.forename: E J
authors.initials: EJ
authors.lastname: Perea
authors.forename: J L
authors.initials: JL
authors.lastname: García-López
authors.forename: R
authors.initials: R
authors.lastname: Martín
authors.forename: M
authors.initials: M
authors.lastname: Calmet
authors.forename: R
authors.initials: R
authors.lastname: Cisterna
authors.forename: V
authors.initials: V
authors.lastname: Estébanez
authors.forename: J A
authors.initials: JA
authors.lastname: Vázquez
authors.forename: F
authors.initials: F
authors.lastname: Martín Luengo
authors.forename: A
authors.initials: A
authors.lastname: Altuna
authors.forename: C
authors.initials: C
authors.lastname: Merino
mesh_terms: D001426:Bacterial Proteins / Q000032:analysis; D004352:Drug Resistance, Microbial; D006069:Gonorrhea / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000145:classification / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D010405:Penicillinase / Q000032:analysis; D011446:Prospective Studies; D013030:Spain / Q000453:epidemiology; D014505:Urban Population
chemical_list: D001426:Bacterial Proteins; D010405:Penicillinase
vernacular_title: Sensibilidad a antimicrobianos de 402 cepas de Neisseria gonorrhoeae aisladas en 7 ciudades de España.