title: Serum zinc, copper and selenium in rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is characterized by low serum Zn and high serum Cu. In multiple linear regression both were explained by disease activity parameters. It is suggested that interleukin-1 causes both changes by 1) increasing the metallothionein-mediated hepatic uptake to serum Zn and 2) upregulating ceruloplasmin (acute phase reactant) gene and synthesis in liver and subsequently the level of ceruloplasmin-Cu complexes in the blood. Cu absorption was diminished by zinc intake. Cu- and Zn-dependent erythrocyte SOD was increased in RA. In contrast to plasma GSHPx serum selenium was low in RA and this was associated with disease activity parameters.
authors.affiliation: Fourth Department of Medicine, Central Hospital, Helsinki, Finland.
authors.forename: V
authors.initials: V
authors.lastname: Honkanen
authors.forename: Y T
authors.initials: YT
authors.lastname: Konttinen
authors.forename: T
authors.initials: T
authors.lastname: Sorsa
authors.forename: M
authors.initials: M
authors.lastname: Hukkanen
authors.forename: P
authors.initials: P
authors.lastname: Kemppinen
authors.forename: S
authors.initials: S
authors.lastname: Santavirta
authors.forename: H
authors.initials: H
authors.lastname: Saari
authors.forename: T
authors.initials: T
authors.lastname: Westermarck
mesh_terms: D000375:Aging / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood*; D003300:Copper / Q000008:administration & dosage / Q000097:blood*; D004032:Diet; D004912:Erythrocytes / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D012044:Regression Analysis; D012643:Selenium / Q000008:administration & dosage / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood; D015032:Zinc / Q000008:administration & dosage / Q000097:blood*
chemical_list: D003300:Copper; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium; D015032:Zinc