title: [Respiratory response to chemical stimuli and exercise capacity under conditions of acute hypoxia in elite mountain climbers].
abstract: To investigate the factors that modulate exercise performance at extreme altitude, the role of the following variables was analyzed in 16 climbers: 1) ventilatory response to chemical stimuli (hypoxia and hypercapnia); and, 2) maximum exercise performance while breathing room air and during acute hypoxia (F1O2, 0.11). Seven climbers (elite climbers, AE) had previously ascended to 8,000 m or more above sea level, and 9 (A) had never achieved such extreme altitude. Then healthy sedentary subjects (C) of similar age (31.1 +/- 6.0 SD years) were used as control group. Elite climbers showed higher ventilatory responses to both transient hypoxia (-0.49 +/- 0.13 L x min-1 x %-1) (p less than 0.05) and progressive hypoxia (-0.47 +/- 0.13 L x min-1 x %-1) than C (-0.33 +/- 0.14 and -0.30 +/- 0.15 L x min-1 x %-1, respectively). By contrast, no differences were observed between the two groups of climbers. The ventilatory response to hypercapnia was higher in AE (3.04 +/- 1.03 L x min-1 mmHg-1) compared to A (1.85 +/- 0.73 L x min-1 mmHg-1) (p less than 0.05) but similar to that observed in C. Breathing 11% O2, maximum workload and oxyhemoglobin desaturation during maximum exercise were similar in both groups of climbers. Additionally, the ventilatory response to hypoxia did not correlate with maximum workload (F1O2, 0.11), maximal ventilation during exercise (F1O2, 0.11), nor with the altitude score. The present study supports previous reports that inform about the role of the ventilatory response to hypoxia in the exercise performance at high altitude.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Servei de Pneumologia, Hospital Clínic, Universitat de Barcelona, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Montserrat
authors.forename: T
authors.initials: T
authors.lastname: Ricard
authors.forename: M
authors.initials: M
authors.lastname: Mateu
authors.forename: J
authors.initials: J
authors.lastname: Roca
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez-Roisín
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000531:Altitude; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume; D006339:Heart Rate; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009051:Mountaineering; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000032:analysis; D005082:Physical Exertion / Q000502:physiology*; D012119:Respiration / Q000502:physiology*; D012129:Respiratory Function Tests
chemical_list: D010108:Oxyhemoglobins; D010100:Oxygen
vernacular_title: Respuesta ventilatoria a estímulos químicos y capacidad de ejercicio en condiciones de hipoxia aguda en alpinistas de elite.