title: Biosynthesis of beta-(isoxazolin-5-on-2-yl)alanine, the precursor of the neurotoxic amino acid beta-N-oxalyl-L-alpha,beta-diaminopropionic acid.
abstract: beta-(Isoxazolin-5-on-2-yl)alanine (BIA), a biosynthetic precursor of the neurotoxic amino acid beta-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), was confirmed to be derived from O-acetyl-L-serine (OAS) and isoxazolin-5-one by cysteine synthase in higher plants. Some properties of this enzyme in the biosynthesis of BIA are described.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba University, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Ikegami
authors.forename: S
authors.initials: S
authors.lastname: Itagaki
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: G
authors.initials: G
authors.lastname: Ongena
authors.forename: Y H
authors.initials: YH
authors.lastname: Kuo
authors.forename: F
authors.initials: F
authors.lastname: Lambein
authors.forename: I
authors.initials: I
authors.lastname: Murakoshi
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives*; D000599:Amino Acids, Diamino; D007887:Fabaceae / Q000378:metabolism*; D007555:Isoxazoles; D009498:Neurotoxins / Q000096:biosynthesis*; D010946:Plants, Medicinal
chemical_list: D000599:Amino Acids, Diamino; D007555:Isoxazoles; D009498:Neurotoxins; C100126:oxalyldiaminopropionic acid; C074507:(isoxazolin-5-on-2-yl)alanine; D000409:Alanine