Protective effect of a high protein diet against the toxicity of some organophosphorus compounds in albino rats.
The present investigation deals with determining the efficacy of a high protein diet (HPD) in combating toxicity in albino rats of some organophosphorus compounds (OPCs) that follow dissimilar metabolic patterns in a living system. As assessed by an increase or decrease in the levels of some biochemical and nutritional parameters, the high protein diet containing 59% protein seems to have a beneficial effect in alleviating toxicity of low but prolonged doses of OPCs over the standard diet (SD) containing 19% protein. OPCs undergoing direct detoxication in a living system like diisopropyl phosphoro-fluoridate (DFP) appear to be more susceptible to HPD than those undergoing biotoxication like EPN (O-ethyl O-p-nitrophenyl phenyl-phosphonothioate) and malathion (S-(1,2-dicarbethoxyethyl) O,O-dimethyldithiophosphate).
Chatterjee
A K
AK
Defense Research and Development Establishment, Gwalior, India.
Kaveeshwar
U
U
D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004044:Dietary Proteins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005916:Globulins / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007531:Isoflurophate / Q000009:adverse effects; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D008294:Malathion / Q000009:adverse effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009943:Organophosphorus Compounds / Q000009:adverse effects*; D004849:Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester / Q000009:adverse effects; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000378:metabolism
D002800:Cholinesterase Inhibitors; D004044:Dietary Proteins; D005916:Globulins; D009943:Organophosphorus Compounds; D012709:Serum Albumin; D007531:Isoflurophate; D004849:Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; D006003:Glycogen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008294:Malathion