title: Relationship between topological properties and biological activity of platinum (II) complexes.
abstract: A graph-theoretical method is applied to model of the relations between structure and biological activity of the anticancer Pt(II) complexes. Values of LD50, ID90, TI and % of ILS resulted from the treatment of animals bearing experimentalis ADJ/PC6 or L1210 tumors, available in the literature, were used as parameters characterizing the antitumor activity of platinum complexes. The results indicate that it is possible to find a topological description of these complexes which could be useful in their structure - activity investigations.
authors.affiliation: Institute of Chemistry, Wrocław University.
authors.forename: K
authors.initials: K
authors.lastname: Romanowska
authors.forename: J
authors.initials: J
authors.lastname: Kuduk-Jaworska
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010984:Platinum / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D010984:Platinum