title: [Immunologic profile of HIV-2 seropositive African individuals (follow-up)].
abstract: In the geographic distribution of HIV-2, it is known that this infection is most prevalent in West Africa. Since 1986 we have studied seropositive and seronegative clusters, in Guinea-Bissau with follow-ups in 1988, 1989, 1990 and 1991. Analysis of the results show the high incidence of this infection. 8.51% of the 4,372 people of the general population studied were seropositive, showing the high predominance of HIV-2 infection. Only 4 cases were exclusively reactive to HIV-1 and a slow evolution of HIV-1 infections. In the seroconversions of HIV-2 infections the antibodies appeared first to the core components and secondly to the surface glycoproteins. Some of the laboratory parameters affected in the evolution of the infection include a gradual increase in immunoglobulins and a decrease in CD4 lymphocytes and in the CD4/CD8 ratio. A comparison of these variations in HIV-2 infected people, with or without cross-reactivity to HIV-1, reveals that they are much more evident in exclusively HIV-2 positive people. This fact can indicate that the variants responsible for the cross-reactions are less pathogenic and phylogenetically less developed.
authors.affiliation: Instituto de Higiene e Medicina Tropical, Laboratório de Imunologia, I.P.O.F.G., Lisboa.
authors.forename: A S
authors.initials: AS
authors.lastname: Pinto
authors.forename: W F
authors.initials: WF
authors.lastname: Ferreira
authors.forename: C
authors.initials: C
authors.lastname: Costa
authors.forename: A P
authors.initials: AP
authors.lastname: Silva
authors.forename: E P
authors.initials: EP
authors.lastname: Alvarez
authors.forename: R A
authors.initials: RA
authors.lastname: Sousa
authors.forename: K
authors.initials: K
authors.lastname: Mansinho
authors.forename: J L
authors.initials: JL
authors.lastname: Champalimaud
authors.forename: C
authors.initials: C
authors.lastname: Araújo
authors.forename: F
authors.initials: F
authors.lastname: Dias
mesh_terms: D000354:Africa, Western; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000276:immunology*; D015498:HIV-2 / Q000276:immunology*; D006801:Humans
vernacular_title: Perfil imunológico de indivíduos africanos HIV-2 seropositivos (follow-up).