Influence of anticoagulants on growth and vitamin K production of intestinal bacteria.
The influence of anticoagulants on growth and vitamin K production of intestinal bacteria was studied. Bacteroides vulgatus and Escherichia coli were grown in vitro in the presence of increasing amounts of warfarin, phenprocoumon and acenocoumarol. It was found that growth of B. vulgatus was inhibited under anaerobic conditions whereas growth of E. coli under aerobic conditions was not inhibited. A specific inhibition of vitamin K biosynthesis was not observed in either case. It is concluded that therapeutic doses of anticoagulants are unlikely to affect growth or vitamin K production of intestinal bacteria.
Johanni
M
M
Institut für Pharmazeutische Biologie, Rheinischen Friedrich-Wilhelms-Universität Bonn.
Ungerechts
J
J
Werner
H
H
Leistner
E
E
D000074:Acenocoumarol / Q000494:pharmacology; D000332:Aerobiosis; D000693:Anaerobiosis; D000925:Anticoagulants / Q000494:pharmacology*; D001439:Bacteroides / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010644:Phenprocoumon / Q000494:pharmacology; D014812:Vitamin K / Q000096:biosynthesis*; D014859:Warfarin / Q000494:pharmacology
D000925:Anticoagulants; D014812:Vitamin K; D014859:Warfarin; D000074:Acenocoumarol; D010644:Phenprocoumon