Alteration of primate ovary surface epithelium by exposure to hexachlorobenzene: a quantitative study.
Hexachlorobenzene (HCB) is a fungicide and a pollutant of increasing concern in industrialized regions of the world. Reproductive failure is one of the effects of HCB upon mammals. Alteration of cell shape in the ovary surface epithelium (OSE) of Cynomolgus monkeys following oral administration of HCB was observed in this study. At the lowest dose used, 0.1 mg/kg body weight, a dosage that is associated with follicular degeneration, HCB caused quantifiable changes in length-to-width ratios of OSE. Measurement of cell shape by light microscopy offers a reliable indication of OSE changes induced by HCB.
Sims
D E
DE
Department of Anatomy and Physiology, Faculty of Veterinary Medicine, University of Prince Edward Island, Charlottetown, Canada.
Singh
A
A
Donald
A
A
Jarrell
J
J
Villeneuve
D C
DC
D000818:Animals; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D006581:Hexachlorobenzene / Q000633:toxicity*; D050356:Lipid Metabolism; D007986:Luteinizing Hormone / Q000008:administration & dosage; D008252:Macaca fascicularis; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D012098:Reproduction / Q000187:drug effects
D006063:Chorionic Gonadotropin; D004785:Environmental Pollutants; D006581:Hexachlorobenzene; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone