Blood clearances of 99mTc-phytate and indocyanine green in carbon tetrachloride treated dogs.
The comparative study of the blood clearances of 99mTc-phytate (99mTc-P) and indocyanine green (ICG) was carried out in dogs with hepatic injury induced by carbon tetrachloride (CCl4), and the blood clearance of 99mTc-P or ICG was compared with the levels of serum transaminase and bilirubin. The blood clearances of 99mTc-P and ICG in dogs decreased with increase in doses of CCl4 and with elapsed time after CCl4 administration. The decreases were correspondent to the increase in serum transaminase activity and bilirubin level. The blood clearance test of 99mTc-P in dogs showed a equal degree of sensitivity and a higher degree of accuracy for the acute hepatic dysfunction induced by CCl4 as compared with the blood clearance test of ICG.
Shibata
H
H
Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.
Odani
N
N
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity*; D004285:Dogs; D005260:Female; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010833:Phytic Acid / Q000493:pharmacokinetics*
D015609:Organotechnetium Compounds; C026177:technetium phytate; D010833:Phytic Acid; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007208:Indocyanine Green; D001663:Bilirubin