title: Diode array detection and simultaneous quantitation of the coeluting atenolol-related synthetic route impurities, PPA-Diol.
abstract: The diode array multichannel detector is used to acquire spectral information at specified intervals in the elution profile of atenolol and its related impurities for post-chromatographic data analysis. The applicability of a number of peak homogeneity testing methods, including spectral normalization, absorbance ratio, chromatographic derivatives, and spectral suppression (SS), are assessed for suitability in simultaneous determinations of the coeluting atenolol-related synthetic impurities, PPA-Diol. Spectral suppression displays a superior performance in comparison to all the other techniques in that both qualitative and quantitative information are acquired on the system.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, W.Y., United Kingdom.
authors.forename: E
authors.initials: E
authors.lastname: Owino
authors.forename: B J
authors.initials: BJ
authors.lastname: Clark
authors.forename: A F
authors.initials: AF
authors.lastname: Fell
mesh_terms: D000081:Acetamides / Q000032:analysis*; D001262:Atenolol / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D010636:Phenols / Q000032:analysis; D010647:Phenyl Ethers / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000081:Acetamides; D010636:Phenols; D010647:Phenyl Ethers; C074036:4-(hydroxyphenyl)acetamide; D001262:Atenolol; C074085:4-(2,3-dihydroxypropoxy)phenyl acetamide