title: Topical sucralfate: effective therapy for the management of resistant peristomal and perineal excoriation.
abstract: Peristomal and perineal excoriation commonly occurs despite preventive measures. Drainage from around gastrostomy tubes or ongoing perineal soilage after a pull-through procedure can lead to chemical irritation, cutaneous denudation, and chronic discomfort. A multitude of topical agents have been tried with variable results. We present our experience using topical sucralfate. Fifteen patients with stomal or perineal skin ulceration were treated with topical sucralfate only after other agents had failed. Clinical photographs were obtained first. Sucralfate, prepared as either a powder or an emollient, was liberally applied to the affected area during diaper changes or when the stomal appliance was emptied. For tube gastrostomy sites, sucralfate was applied every 4 to 6 hours as required to maintain a visible layer. In 13 patients, complete healing occurred. Recovery time was dependent on the severity and extent of skin denudation. Partial healing occurred in one patient. In another patient, the skin excoriation healed but a residual candidal rash required addition of an antifungal agent. General observations included: (1) a lag time of 2 to 3 days before visible healing was evident; (2) healing occurred from the perimeter; (3) sucralfate was soothing and reduced discomfort; (4) it was ineffective for fungal dermatitis; and (5) sucralfate did not appear to have toxic or systemic effects. Topically applied sucralfate is soothing, safe, and effective.
authors.affiliation: Department of Surgery, IWK Children's Hospital, Halifax, Nova Scotia, Canada.
authors.forename: A H
authors.initials: AH
authors.lastname: Hayashi
authors.forename: H Y
authors.initials: HY
authors.lastname: Lau
authors.forename: D A
authors.initials: DA
authors.lastname: Gillis
mesh_terms: D000005:Abdomen; D000287:Administration, Topical; D002675:Child, Preschool; D005774:Gastrostomy / Q000009:adverse effects; D006801:Humans; D007223:Infant; D008297:Male; D010502:Perineum; D012883:Skin Ulcer / Q000188:drug therapy* / Q000209:etiology; D013392:Sucralfate / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D013392:Sucralfate