title: COR3224--a new antidepressant: pharmacokinetics and metabolism in rat.
abstract: COR3224 is a new 2-amino-2 oxazoline derivative with antidepressant properties. The distribution, excretion and metabolism of radiochemically labelled 14C-COR3224 has been investigated in the rat after intravenous injection. The compound was widely distributed and rapidly excreted. Hydroxylation and sulphate conjugation are involved in the COR3224 elimination.
authors.affiliation: Centre de Recherche, Laboratories Sorget, Mérignac, France.
authors.forename: B
authors.initials: B
authors.lastname: Neau
authors.forename: I
authors.initials: I
authors.lastname: Damaj
authors.forename: B
authors.initials: B
authors.lastname: Lambrey
authors.forename: J P
authors.initials: JP
authors.lastname: Akbaraly
authors.forename: J
authors.initials: J
authors.lastname: Roux
authors.forename: D
authors.initials: D
authors.lastname: Perrissoud
authors.forename: J
authors.initials: J
authors.lastname: Jacquot
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D005243:Feces / Q000737:chemistry; D006207:Half-Life; D006900:Hydroxylation; D007275:Injections, Intravenous; D008297:Male; D010080:Oxazoles / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D010080:Oxazoles; D013431:Sulfates; C056984:COR 32-24