Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites.
Raddatz
P
P
E. Merck Pharmaforschung, Darmstadt, Germany.
Jonczyk
A
A
Schmitges
C J
CJ
Sombroek
J
J
D000595:Amino Acid Sequence; D000818:Animals; D002918:Chymotrypsin / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D000092502:Renin Inhibitors
D002918:Chymotrypsin; D009842:Oligopeptides; D000092502:Renin Inhibitors