Antiendothelial cell antibodies in patients with the antiphospholipid syndrome.
Antiendothelial cell antibodies (AECA) have been detected in 20 out of 30 patients (67%) with thrombosis associated with antiphospholipid antibodies. Seven patients had systemic lupus erythematosus and 13 had the "primary" antiphospholipid syndrome. Seven patients had both IgG and IgM AECA, 9 had IgG AECA only, and 4 had only IgM AECA. None of 30 control patients with thrombotic events not related to antiphospholipid antibodies had a positive titre of AECA (P less than 0.001). No correlation between AECA, antinuclear antibodies, anti-dsDNA antibodies, anti-neutrophil cytoplasm antibodies, precipitating antibodies to soluble nuclear and cytoplasmic antigens or complement components was found. The possible role of these AECA in the pathogenesis of thrombotic events is discussed.
Cervera
R
R
Lupus Arthritis Research Unit, Rayne Institute, St. Thomas' Hospital, London, United Kingdom.
Khamashta
M A
MA
Font
J
J
Ramírez
G
G
D'Cruz
D
D
Montalbán
J
J
López-Soto
A
A
Asherson
R A
RA
Ingelmo
M
M
Hughes
G R
GR
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear / Q000032:analysis; D034961:Antigens, Nuclear; D016736:Antiphospholipid Syndrome / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens / Q000032:analysis; D002308:Cardiolipins / Q000276:immunology; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D004727:Endothelium / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D016682:Lupus Coagulation Inhibitor / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D009687:Nuclear Proteins / Q000276:immunology; D010743:Phospholipids / Q000276:immunology; D013927:Thrombosis / Q000276:immunology
D000906:Antibodies; D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear; D034961:Antigens, Nuclear; D001323:Autoantibodies; D001324:Autoantigens; D002308:Cardiolipins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016682:Lupus Coagulation Inhibitor; D009687:Nuclear Proteins; D010743:Phospholipids