[Effect of humoral factors of the spleen of rats with acute and chronic toxic liver involvement on the physiologic and reparative regeneration of hepatocytes].
It was demonstrated in experiments on Wistar rats with carbon tetrachloride induced acute and chronic affection of the liver that the supernatant of the splenic cells of the poisoned animals contains 2 undialyzable factors with a molecular mass of more than 150 and 10-12 kDa. The splenocytic substances stimulate hepatocyte proliferation both in healthy allogeneic recipients and under conditions of increased proliferative activity of hepatocytes in experimental pathology of the liver.
Konoplia
A I
AI
Shveĭnov
I A
IA
Prokopenko
L G
LG
Konoplia
E N
EN
D000208:Acute Disease; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000503:physiopathology*; D002908:Chronic Disease; D005260:Female; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D011506:Proteins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000737:chemistry*
D011506:Proteins
Vliianie gumoral'nykh faktorov selezenki krys s ostrym i khronicheskim toksicheskim porazheniem pecheni na fiziologicheskuiu i reparativnuiu regeneratsiiu gepatotsitov.