title: [Ictal and interictal 99mTc-HMPAO-SPECT studies in temporal lobe epilepsy with unilateral EEG focus].
abstract: Ictal and interictal SPECT measurements using 99mTc-HMPAO are helpful in localising an epileptic focus. 24 patients (12 women and 12 men; mean age 30 years) suffering from temporal lobe epilepsies with unilateral EEG foci were examined. In all patients a presurgical evaluation including sphenoidal and foramen oval electrodes was carried out. The analysis of SPECT measurement was done visually and semi-quantitatively, comparing the data with findings in healthy persons (10 women and 10 men; mean age 24 years). The etiology of the epilepsy was confirmed by histological investigation in 16 cases, and by CT and MRI in 8 cases. The findings were gliosis in 6 cases, astrocytoma in 3 cases, cysts in 4 cases, and angioma in 3 cases. In 8 cases no pathological findings could be detected. In 46% of cases interictal SPECTs exhibited a focal hypoperfusion corresponding with the EEG-focus. In ictal SPECTs this could be found in 75% of cases. In all 10 patients without morphological findings or with gliosis (proved by histological investigations) a hyperperfusion coincident with the EEG-focus appeared in ictal SPECTs.
authors.affiliation: Neurologische Klinik mit Poliklinik, Universität Erlangen-Nürnberg.
authors.forename: J
authors.initials: J
authors.lastname: Bauer
authors.forename: H
authors.initials: H
authors.lastname: Stefan
authors.forename: H
authors.initials: H
authors.lastname: Feistel
authors.forename: P
authors.initials: P
authors.lastname: Schüler
authors.forename: G
authors.initials: G
authors.lastname: Platsch
authors.forename: U
authors.initials: U
authors.lastname: Neubauer
authors.forename: B
authors.initials: B
authors.lastname: Neundörfer
mesh_terms: D000293:Adolescent; D000328:Adult; D001812:Blood-Brain Barrier / Q000502:physiology; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology; D002540:Cerebral Cortex / Q000098:blood supply*; D004292:Dominance, Cerebral / Q000502:physiology*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon
vernacular_title: Iktuale und interiktuale 99mTc-HMPAO-SPECT Untersuchungen bei Temporallappenepilepsien mit unilateralem EEG-Fokus.