Frequencies of HLA-DR3, -DR4, -B8 and -Bw62 in diabetic children diagnosed between 1960 and 1990.
An analysis of the HLA-types of 351 children in whom a diagnosis of insulin dependent diabetes mellitus (IDDM) had been made between 1960 and 1990 revealed that although the frequencies of HLA-DR3, -DR4, -DR3/4, -B8 and -Bw62 were increased there was, depending on the year of diagnosis, a marked fluctuation in the frequencies of these HLA-antigens and in the frequency with which -B8 was associated with -DR3 and -Bw62 with -DR4 suggesting heterogeneity/variation in agents initiating/triggering IDDM.
Mäenpää
A
A
Department of Pathology, University of Helsinki, Finland.
Koskimies
S
S
Scheinin
T
T
Schlenzka
A
A
Akerblom
H K
HK
Mäenpää
J
J
Reunanen
A
A
Kontiainen
S
S
D002644:Chickenpox / Q000453:epidemiology; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000276:immunology*; D005387:Finland / Q000453:epidemiology; D015235:HLA-B Antigens / Q000032:analysis*; D059910:HLA-B15 Antigen; D015795:HLA-B8 Antigen / Q000032:analysis*; D015803:HLA-DR3 Antigen / Q000032:analysis*; D015804:HLA-DR4 Antigen / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D015994:Incidence; D008457:Measles / Q000453:epidemiology; D009107:Mumps / Q000453:epidemiology; D011336:Probability; D012189:Retrospective Studies; D014505:Urban Population
D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D015795:HLA-B8 Antigen; C044141:HLA-Bw62; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen