title: Toxicokinetics of aromatic amines in guppy, Poecilia reticulata.
abstract: In this study the elimination kinetics of several chlorinated anilines and a tetrachlorobenzene in guppy, Poecilia reticulata, have been determined. The elimination of all the chlorinated anilines in fish showed a bi-phasic pattern, whereas the elimination characteristics of the tetrachlorobenzene are in agreement with a one-compartment model. Elimination of the chlorinated anilines is faster than elimination of the tetrachlorobenzene. The small differences in octanol-water partition coefficient of these compounds can only in part describe the differences in elimination rate. The observed differences might be attributed to differing biotransformation rates.
authors.affiliation: Research Institute of Toxicology, University of Utrecht, Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: de Wolf
authors.forename: E
authors.initials: E
authors.lastname: Yedema
authors.forename: W
authors.initials: W
authors.lastname: Seinen
authors.forename: J L
authors.initials: JL
authors.lastname: Hermens
mesh_terms: D000814:Aniline Compounds / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D002722:Chlorobenzenes / Q000378:metabolism* / Q000633:toxicity; D006207:Half-Life; D007700:Kinetics; D011036:Poecilia / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000814:Aniline Compounds; D002722:Chlorobenzenes; C074538:2,3,5,6-tetrachloroaniline; C074537:2,3,4,5-tetrachloroaniline; C030387:1,2,3,5-tetrachlorobenzene; C027673:2,3,4,5,6-pentachloroaniline