[Monoclonal antibodies to DNA, modified with osmium tetraoxide in the presence of 2,2'-bipyridine].
A monoclonal antibody (IgG) has been produced that binds to DNA modified with osmium tetroxide and 2,2'-bipyridine and does not react with unmodified DNA and modified or unmodified RNA and proteins. The reaction specificity is due to the presence of the modified deoxythymidine residue within the epitope. Possible use of the antibody for studies of DNA structure and detection of cDNA probes is discussed.
Kabakov
A E
AE
Brovkina
L N
LN
Podgordnichenko
V K
VK
Poverennyĭ
A M
AM
D015082:2,2'-Dipyridyl / Q000378:metabolism*; D000818:Animals; D000911:Antibodies, Monoclonal; D000915:Antibody Affinity; D002417:Cattle; D004247:DNA / Q000276:immunology* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D006825:Hybridomas; D007136:Immunoglobulins / Q000276:immunology / Q000378:metabolism; D009993:Osmium Tetroxide / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D007136:Immunoglobulins; D015082:2,2'-Dipyridyl; D004247:DNA; D009993:Osmium Tetroxide
Monoklonal'nye antitela k DNK, modifitsirovannoĭ tetraoksidom osmiia v prisutstvii 2,2'-bipiridina.