title: Bilirubin accumulation by the rabbit choroid plexus in vitro.
abstract: The postnatal development of bilirubin accumulation by the choroid plexus was studied in vitro. Choroid plexus of the fourth and lateral cerebral ventricles from adult or 1-, 7-, 15- or 21-day-old rabbits were incubated in a potassium-rich medium with 70 nmol/l of 3H-bilirubin for 5 min. The tissue/medium (T/M) ratio for 3H-bilirubin was considerable even 1 day post partum and increased during the next 2-3 weeks of life. In adults the 3H-bilirubin T/M ratio returned to the level of 1-day-old rabbits. The biliary excreted contrast agent iodipamide, added as a transport inhibitor, reduced the 3H-bilirubin T/M ratio in the choroid plexus, but to a relatively lesser extent in the 1-day-old rabbits than in the older ones.
authors.affiliation: Department of Pediatrics, University of Uppsala, Sweden.
authors.forename: A M
authors.initials: AM
authors.lastname: Jakobson
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001663:Bilirubin / Q000378:metabolism*; D002831:Choroid Plexus / Q000378:metabolism*; D046508:Culture Techniques; D005260:Female; D007672:Kidney Cortex / Q000378:metabolism; D007679:Kidney Medulla / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D011817:Rabbits; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000378:metabolism
chemical_list: D013757:Tetraethylammonium Compounds; D019789:Tetraethylammonium; D001663:Bilirubin