title: Efficacy of methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2-carbamate, a metabolite of mebendazole, against developing forms of experimental helminth parasites.
abstract: Methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2- carbamate, a metabolite of mebendazole, was evaluated against metamorphic forms of Ancylostoma ceylanicum in hamsters, Nippostrongylus brasiliensis in rats and cysticercoids of Hymenolepis nana in grain beetles. The test compound offered better action than mebendazole except against H. nana cysticercoids where the activity of the compound and mebendazole was comparable, but was inferior to the standard cestodicidal drug, praziquantel. The results suggest that the action was better by ip route compared to per os route of drug administration.
authors.affiliation: Division of Parasitology, Central Drug Research Institute, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: J K
authors.initials: JK
authors.lastname: Srivastava
authors.forename: M K
authors.initials: MK
authors.lastname: Jain
authors.forename: J C
authors.initials: JC
authors.lastname: Katiyar
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: D S
authors.initials: DS
authors.lastname: Bhakuni
mesh_terms: D000722:Ancylostoma / Q000187:drug effects* / Q000254:growth & development; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001517:Coleoptera; D006926:Hymenolepis / Q000187:drug effects* / Q000254:growth & development; D007814:Larva; D008463:Mebendazole / Q000031:analogs & derivatives* / Q000494:pharmacology; D009559:Nippostrongylus / Q000187:drug effects* / Q000254:growth & development; D011223:Praziquantel / Q000494:pharmacology; D012377:Rodentia
chemical_list: D000871:Anthelmintics; C041590:5-hydroxymebendazole; D011223:Praziquantel; D008463:Mebendazole