[The effect of a polypeptide complex isolated from the animal prostate on thrombus formation].
The authors studied the effect of polypeptides, which were obtained from the prostate of cattle and were related to the class of cytomedines, on the formation of thrombi in the venules of the mesentery in rats. Thrombosis of the venules was induced by laser irradiation, the thrombogenesis parameters were measured with a TV microscope. Intramuscular injection of the preparation and its local action on the mesenteric vessels reduced the time of growth and the size of the thrombi in the experimental animals as compared to that in the controls. The obtained data are evidenced that the preparation produces an inhibiting effect on the thrombocyte-vascular mechanism of hemostasis by increasing the thromboresistance of the vascular wall.
Petrishchev
N N
NN
Mikhaĭlova
N A
NA
Gorbachev
A G
AG
Agulianskiĭ
L I
LI
Khavinson
V Kh
VKh
D000818:Animals; D002417:Cattle; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005343:Fibrinolytic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D010455:Peptides / Q000302:isolation & purification / Q000627:therapeutic use*; D011467:Prostate; D051381:Rats; D013927:Thrombosis / Q000517:prevention & control*
D005343:Fibrinolytic Agents; D010455:Peptides; C073434:prostalin
Vliianie kompleksa polipeptidov, vydelennykh iz predstatel'noĭ zhelezy zhivotnykh, na tromboobrazovanie.