Enhancement of endogenous prostaglandin I2 (prostacyclin) generation in vivo by a phenolic anti-inflammatory agent in the rabbit.
Angiotensin II (i.v.) increased the plasma level of 6-keto-PGF1 alpha from 241 +/- 60 pg/ml (n = 8) to 612 +/- 108 pg/ml (n = 8) in anesthetized rabbits, which was further significantly increased by pretreatment with a phenolic anti-inflammatory agent, MK-447, to 1007 +/- 218 pg/ml (n = 8). MK-447 alone did not affect the level. The level of thromboxane B2 was not affected by these treatments. These results suggest that MK-447 may selectively enhance the PGI2 level by acting as a tryptophan-like cofactor of PG endoperoxide synthase.
Kawamura
M
M
Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan.
Harada
Y
Y
Katori
M
M
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000031:analogs & derivatives* / Q000494:pharmacology; D011464:Epoprostenol / Q000096:biosynthesis*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D013929:Thromboxane B2 / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000804:Angiotensin II; D002084:Butylated Hydroxytoluene; D013929:Thromboxane B2; C013753:2-aminomethyl-4-t-butyl-6-iodophenol; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D007213:Indomethacin