title: [Subleukemic acute monophagocytic leukemia. A biological phenotype close to malignant histiocytosis].
abstract: An 80 year-old woman presented subleukaemic acute monoblastic leukaemia (AML-M5a). Her bone marrow showed invasion by highly dysplastic histio-monocytic cells of great size and wide cytoplasm, with intense phagocytic activity (erythrophagocytosis was frequently seen), and with abnormal karyotype (50XX, +8, +8, +16, +21). The different malignant and reactive features of the mononuclear phagocytic system are commented, along with the haemophagocytic activity of the histio-monocytic cells in different states. The cytogenetic anomalies more frequently found in AML-M5 are also dealt with as compared to this patient's. The case reported here seems to correspond to subleukaemic acute "monophagocytic" leukaemia, with a biologic phenotype close to that of malignant histiocytosis.
authors.affiliation: Servicio de Hematología, Fundación Jiménez Díaz, Facultad de Medicina, Universidad Autónoma, Madrid.
authors.forename: J
authors.initials: J
authors.lastname: Sánchez Fayos
authors.forename: M A
authors.initials: MA
authors.lastname: Pérez Sáenz
authors.forename: J
authors.initials: J
authors.lastname: Benítez
authors.forename: J
authors.initials: J
authors.lastname: Outeiriño
authors.forename: E
authors.initials: E
authors.lastname: Prieto
authors.forename: T
authors.initials: T
authors.lastname: Calabuig
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D003561:Cytarabine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D015726:Giant Cells / Q000473:pathology; D054747:Histiocytic Sarcoma / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D010587:Phagocytosis; D013866:Thioguanine / Q000008:administration & dosage
chemical_list: D003561:Cytarabine; D005047:Etoposide; D004317:Doxorubicin; D013866:Thioguanine
vernacular_title: Leucemia aguda monofagocítica subleucémica. Un fenotipo biológico próximo a la histiocitosis maligna.