Thrombotic microangiopathy and the antiphospholipid antibody syndrome.
A 23-year-old woman with the antiphospholipid syndrome developed severe thrombocytopenia (14 x 10(9)/l) and microangiopathic hemolytic anemia after plasma exchange. A relation was suspected between rising anticardiolipin level and development of thrombotic microangiopathy. The mechanism responsible may be interference between anticardiolipin antibody, platelet membrane and endothelial cell.
Durand
J M
JM
Department of Internal Medicine, CHU Sainte Marguerite, Marseille, France.
Lefevre
P
P
Kaplanski
G
G
Soubeyrand
J
J
D000328:Adult; D000743:Anemia, Hemolytic / Q000150:complications*; D000906:Antibodies / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000276:immunology / Q000628:therapy; D002308:Cardiolipins / Q000276:immunology; D005260:Female; D006801:Humans; D008833:Microcirculation; D010951:Plasma Exchange; D013921:Thrombocytopenia / Q000150:complications*
D000906:Antibodies; D002308:Cardiolipins