The in vivo antibody response to hen egg white lysozyme in H-2b-compatible responder and non-responder mice: is it regulated by its N-terminal peptide at the level of antigen-presenting cells?
We studied the in vivo antibody responses of three H-2b strains, BALB/b, C57BL/6 and BALB/B x C57BL/6 F1 to various lysozymes, REL and HEL, after priming with HEL, REL or the HEL N-terminal peptide. It was confirmed that C57BL/6 is a non-responder strain to HEL and that BALB/b is responder strain. The C57BL/6 non-responder trait was associated with HEL or peptide induction of suppressor cells, as shown by adoptive transfer experiments. We further demonstrated that the suppressor/non-responder trait is dominant in BALB/b x C57BL/6 F1 hybrids and that appropriately pulsed macrophages of BALB/b mice can bypass such suppression in these F1 mice. Possible mechanisms are discussed.
Chaouat
G
G
U262 INSERM, Clinique Universitaire Baudelocque, Paris, France.
Kinsky
R
R
Hofmann
R
R
Combe
C R
CR
Kourilsky
P
P
D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology; D004527:Egg Proteins / Q000276:immunology*; D006183:H-2 Antigens / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009113:Muramidase / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology
D004527:Egg Proteins; D006183:H-2 Antigens; D007074:Immunoglobulin G; D010446:Peptide Fragments; D009113:Muramidase