Difference between the cerebrovascular effect of purinergic Co-ATP and that of the cholinesterase inhibitor, physostigmine, in vivo.
Development of the cerebrovascular effect of cobalt-ATP was compared to that of physostigmine in 34 anesthetized rabbits. The resting cortical cerebral blood flow (CBF) was estimated from the H2 clearance and the CBF changes by the heat clearance method. Systemic blood pressure, heart and respiratory rate and cerebral electrical activity were recorded simultaneously. In addition, we measured arterial glucose concentration, pH, PaO2 and PaCO2. Both drugs were found to induce a significant increase in CBF. However, the degree of the CBF increase induced by Co-ATP was inversely related, while that induced by physostigmine was directly related to both the baseline level of CBF and the value of PaCO2. We conclude that the cerebrovascular effect of ATP depends mainly on vessel tone, while the effect of physostigmine is related to the level of PaCO2.
Molnár
L
L
Department of Neurology and Psychiatry, University Medical School, Debrecen, Hungary.
Hegedüs
K
K
Fekete
I
I
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003035:Cobalt / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D008297:Male; D010830:Physostigmine / Q000494:pharmacology*; D011817:Rabbits; D013268:Stimulation, Chemical
D002800:Cholinesterase Inhibitors; D003035:Cobalt; D000255:Adenosine Triphosphate; D010830:Physostigmine