title: A rapid intraoperative estimation of the proliferative activity in brain tumors.
abstract: A technique for staining the nucleolar organizer regions (NORs) in tumor cells applied to smears from brain tumor biopsy specimens is described. This technique provides a rapid intraoperative evaluation of the proliferative activity in cerebral neoplasms and is a valuable complement to hematoxylineosin stained smears, supporting the criteria of benignity or malignancy in these tumors.
authors.affiliation: Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Vaquero
authors.forename: R
authors.initials: R
authors.lastname: Martínez
authors.forename: A
authors.initials: A
authors.lastname: Arias
authors.forename: S
authors.initials: S
authors.lastname: Oya
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D002455:Cell Division; D006651:Histocytochemistry / Q000379:methods; D006801:Humans; D007432:Intraoperative Period; D009697:Nucleolus Organizer Region / Q000737:chemistry*; D016622:Silver Staining; D013238:Stereotaxic Techniques