The copper chelating agent tetraethylenepentamine inhibits copper, zinc-superoxide dismutase activity in rat liver: a possible mechanism for its hepatotoxicity.
Ishiyama
H
H
Department of Public Health, Yamaguchi University School of Medicine, Ube, Japan.
Ogino
K
K
Hobara
T
T
Shimomura
Y
Y
Kanbe
Y
Y
Yamashita
S
S
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury; D004333:Drug Administration Routes; D005029:Ethylenediamines / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors*; D014266:Trientine / Q000494:pharmacology
D002614:Chelating Agents; D005029:Ethylenediamines; D013482:Superoxide Dismutase; D000410:Alanine Transaminase; D005978:Glutathione; D014266:Trientine; C034269:tetraethylenepentamine