title: Further studies on the susceptibility of Bulinus africanus to infection with Schistosoma haematobium.
abstract: Genetic manipulation of the intermediate host snails of schistosomiasis has been proposed as a possible method of reducing the rate at which the parasite is transmitted to the final host. This technique is based on the finding that snail-schistosome compatibility is variable, and that refractory snails could be introduced into natural habitats in an attempt to change existing highly-susceptible populations into non-susceptible ones. In our search for such a refractory snail population, offspring from eight different Bulinus africanus populations were infected with Schistosoma haematobium, isolated from school children in the Nelspruit district. A great variation in minimum prepatent period was recorded (33-55 days), while the infected snails surviving that period ranged from 22-89%. A significant difference was found between the infection rates of B. africanus from Newlands in Natal and those of the other seven populations from the Eastern Transvaal Lowveld. The former population could be regarded as partially refractory, and none of the other populations proved to be completely refractory, to infection.
authors.affiliation: Research Institute for Diseases in a Tropical Environment, South African Medical Research Council, Nelspruit.
authors.forename: P H
authors.initials: PH
authors.lastname: Joubert
authors.forename: S J
authors.initials: SJ
authors.lastname: Pretorius
authors.forename: F J
authors.initials: FJ
authors.lastname: Kruger
mesh_terms: D000818:Animals; D002033:Bulinus / Q000469:parasitology*; D004198:Disease Susceptibility; D004199:Disease Vectors; D012553:Schistosomiasis haematobia / Q000469:parasitology / Q000517:prevention & control / Q000635:transmission*