Effect of sho-saiko-to(xiao-chai-hu-tang) on HBeAg clearance in children with chronic hepatitis B virus infection and with sustained liver disease.
We studied the effect of Sho-saiko-to (Xiao-Chai-Hu-Tang) on HBeAg clearance rate (SN rate) in fourteen children with chronic hepatitis B virus (HBV) infection and with sustained liver disease. Seven of fourteen patients (50.0%) became HBeAg negative in the average observation period of 0.47 years(0.2-0.9 years). Four of those seven patients developed anti-HBe. The annual SN rate in the She-saiko-to treated group was apparently higher than the natural annual SN rate (22.7%) of 22 untreated patients retrospectively reviewed from the onset of hepatitis. Sho-saiko-to seemed to promote clearance of HBeAg in children with chronic HBV infection and with sustained liver disease. Sho-saiko-to may be a useful drug for such patients.
Tajiri
H
H
Department of Pediatrics, Osaka University Hospital, Japan.
Kozaiwa
K
K
Ozaki
Y
Y
Miki
K
K
Shimuzu
K
K
Okada
S
S
D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D006513:Hepatitis B e Antigens / Q000097:blood*; D006801:Humans; D007223:Infant; D008297:Male; D016176:T-Lymphocyte Subsets / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D006513:Hepatitis B e Antigens; C018142:saiko-keishi-to; D000410:Alanine Transaminase