title: Long-term follow-up results in hormonally active pituitary adenomas after primary successful transsphenoidal surgery.
abstract: The long-term results of transsphenoidal surgery for hormonally active pituitary adenomas were assessed in 3 follow-up studies. Eight out of 50 patients with microprolactinomas developed a persisting postoperative re-increase of prolactin levels during an average follow-up period of 4.1 years. None of the 43 acromegalic patients who had achieved a suppression of growth hormone to below 2 ng/ml during an oral glucose load shortly after surgery relapsed. However, when the remission criterion was only based on basal growth hormone below 5 ng/ml 4 out of 61 patients showed a re-increase of growth hormone levels to persistently elevated values during an average follow-up period of 6.1 years. 14 out of 66 patients followed-up for an average of 8.2 years after successful primary microadenomectomy for Cushing's disease developed recurrent hypercortisolism as documented by an abnormal suppression of cortisol after oral low dose dexamethasone.
authors.affiliation: Neurochirurgische Klinik mit Poliklinik, Universität Erlangen-Nürnberg, Federal Republic of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Buchfelder
authors.forename: R
authors.initials: R
authors.lastname: Fahlbusch
authors.forename: W
authors.initials: W
authors.lastname: Schott
authors.forename: J
authors.initials: J
authors.lastname: Honegger
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000601:surgery; D000236:Adenoma / Q000097:blood / Q000601:surgery*; D003480:Cushing Syndrome / Q000097:blood / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006729:Hormones, Ectopic / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000175:diagnosis*; D009384:Paraneoplastic Endocrine Syndromes / Q000097:blood / Q000601:surgery*; D010911:Pituitary Neoplasms / Q000097:blood / Q000601:surgery*; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D015175:Prolactinoma / Q000097:blood / Q000601:surgery; D013101:Sphenoid Sinus / Q000601:surgery
chemical_list: D006729:Hormones, Ectopic; D006854:Hydrocortisone