title: Mortality among the offspring (F1) of atomic bomb survivors, 1946-85.
abstract: We compare the mortality in the years 1946-85 in a cohort of 31,159 children born to parents one or both of whom were exposed to the atomic bombing of Hiroshima and Nagasaki (a parental gonadal dose greater than or equal to 0.01 Sv) with that in a control group of 41,069 children. The average gonadal dose for the exposed parents was 0.435 Sv. The mean age of the cohorts was 28.8 years. In the greater than or equal to 0.01 Sv dose group 1,253 deaths were observed in the subset of children both of whose parents have been assigned DS86 doses. 3.2% were attributed to cancers, 72.9% to all diseases except neoplasms. These proportions in the 0 Sv dose group were about the same. Based on a linear relative risk model, no statistically significant increase in the mortality attributable to diseases other than neoplasms is noted following parental exposure, the excess relative risk being 0.030 (+/- 0.046) per sievert based on the DS86 doses (RBE of neutrons = 20). For fatal cancer, no statistically significant effect of parental radiation dose was also observed. An analysis based on the full sample, using not only the DS86 dose group but also ad hoc dose group, yields essentially the same results as the analysis restricted to the DS86 dose group.
authors.affiliation: Radiation Effects Research Foundation, Department of Epidemiology, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshimoto
authors.forename: W J
authors.initials: WJ
authors.lastname: Schull
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: J V
authors.initials: JV
authors.lastname: Neel
mesh_terms: D000328:Adult; D006801:Humans; D007564:Japan / Q000453:epidemiology; D009026:Mortality; D009689:Nuclear Warfare; D011831:Radiation Genetics