title: [Antitubercular agents. LIV. 3-Alkyl(or -alkyl) thio-2,5-pyrazindicarboxamides].
abstract: From 5-cyano-3-chloro-2-pyrazinecarboxamide) (II) hydrolysis in acid medium) yielded 3-chloro-2,5-pyrazinedicarboxamide (III), which in a reaction with sodium hydrogensulfide in dimethyl-formamide) yielded 3-mercapto-2,5-pyrazinedicarboxamide (IV). This compound through condensations with alkyl- and arylhalogenides in triethylamine) yielded 3-alkyl(or aryl) thio-2,5-pyrazinedicarboxamides of type I. The structure of compounds was confirmed by elemental analysis, IR and 1H NMR spectra. A microbiological evaluation was carried out; the antituberculous effect of these compounds is not higher than that of pyrazinamide.
authors.affiliation: Farmaceutická fakulta Univerzity Karlovy, Hradec Králové.
authors.forename: K
authors.initials: K
authors.lastname: Dlabal
authors.forename: K
authors.initials: K
authors.lastname: Palát
authors.forename: M
authors.initials: M
authors.lastname: Machácek
authors.forename: Z
authors.initials: Z
authors.lastname: Odlerová
mesh_terms: D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009170:Nontuberculous Mycobacteria / Q000187:drug effects; D011719:Pyrazines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D011719:Pyrazines
vernacular_title: Antituberkulotika. LIV. 3-Alkyl(resp.aryl)thio-2,5-pyrazindikarboxamidy.