title: Morphogenesis in shape-space. Elementary meta-dynamics in a model of the immune network.
abstract: A unique feature of the immune system is that it possesses meta-dynamics: the process governing the removal of certain clones from the active population and the recruitment of new clones from the pool of lymphocytes freshly produced by the bone marrow. In this paper, we present a computer model which focuses on those aspects of the system that characteristically derive from the meta-dynamics as such. We observe that when a region of shape-space is densely populated, there is an emergence of dynamically quasi-stable configurations. Moreover, when the system develops in the presence of permanent self-antigens, the latter are systematically incorporated into such coherent configurations. We conclude that the meta-dynamics of the biological immune system may be such that it gives rise to the emergence of a connected, self-sustaining network that we call the Central Immune System: a coherent self-identity which incorporates the molecules of the somatic self and, more generally, reflects the history of its own development.
authors.affiliation: Unité d'Immunobiologie, Institut Pasteur, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Stewart
authors.forename: F J
authors.initials: FJ
authors.lastname: Varela
mesh_terms: D001324:Autoantigens / Q000276:immunology; D003198:Computer Simulation; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007108:Immune Tolerance; D008214:Lymphocytes / Q000276:immunology; D008954:Models, Biological; D009024:Morphogenesis / Q000276:immunology
chemical_list: D001324:Autoantigens