title: [The characteristics of cholinesterase distribution in the development of the human and mammalian brains].
abstract: Histochemical studies have been made on the distribution of acetyl- and butyrylcholinesterases (ACHE and BCHE) in various parts of the human and rat brain. Statistical analysis showed that at the 8th week, the highest ACHE activity in the human foetus is observed in the intermediate and plexiform layers of the cerebral cortex. The highest BCHE activity was found in the ependymal layer of various cerebral regions. High BCHE and ACHE activities were noted in the dorsal thalamus and epithalamus. In 10-week human foetuses, total high level of ACHE and BCHE was revealed in various nuclei of the thalamus and subcortical structures of the forebrain (Meynert nucleus, nucleus caudatum). In rats, the highest ACHE activity at the 14th day of prenatal life was found only in subcortical structures of the forebrain. Accumulation of BCHE activity in some of the thalamic nuclei of rats begins at the 10-17th day of postnatal life.
authors.forename: I A
authors.initials: IA
authors.lastname: Chernyshevskaia
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D002091:Butyrylcholinesterase / Q000378:metabolism; D002802:Cholinesterases / Q000378:metabolism*; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D005333:Fetus; D006651:Histocytochemistry; D006801:Humans; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014426:Turtles
chemical_list: D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D002802:Cholinesterases
vernacular_title: Osobennosti raspredeleniia kholinésteraz v razvitii mozga cheloveka i mlekopitaiushchikh.