Comparison of oral bioavailability of two dosage-forms of progesterone in women.
For poorly water soluble drugs, the dissolution process in biological fluids the rate limiting step in absorption. However, the utilization of some galenic processes such as solid dispersions (SD) leads to an improvement in quality and intensity of the drug gastro-intestinal absorption. In a previous work, the in vitro studies of the dissolution curves of both the pure micronized progesterone (MP) and the progesterone-PEG 6000 SD revealed marked increases in the progesterone dissolution rates for all the SD investigated compared to the pure MP. The aim of this work was to investigate the in vitro results after oral administration of the two pharmaceutical forms to menopaused volunteer women.
Duclos
R
R
Laboratoire de Pharmacie Galnique, UFR deMdecine-Pharmacie de Rouen, France.
Clabaut
M
M
Daoust
M
M
D000284:Administration, Oral; D001682:Biological Availability; D002214:Capsules; D005079:Excipients; D005260:Female; D006801:Humans; D008875:Middle Aged; D011092:Polyethylene Glycols; D011374:Progesterone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011863:Radioimmunoassay
D002214:Capsules; D005079:Excipients; D011092:Polyethylene Glycols; D011374:Progesterone