Isolation of a new antitumor substance from Bacillus stearothermophilus.
A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-D1 (IC50: 4 micrograms/ml) and mouse mastocytoma, P-815 (IC50: 0.6 microgram/ml), but not that of Balb/c 3T3.
Kohama
Y
Y
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Teramoto
T
T
Iida
K
K
Murayama
N
N
Semba
T
T
Tatebatake
N
N
Kayamori
Y
Y
Tsujikawa
K
K
Mimura
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D001411:Geobacillus stearothermophilus / Q000737:chemistry*; D051379:Mice
D000970:Antineoplastic Agents