title: Role of the early epithelium in the patterning of the teeth and Meckel's cartilage.
abstract: Embryonic epithelium from the mandibular branchial arch organizes the dentition and the deposition of Meckel's cartilage. During 9-11 days of gestation mandibular arch epithelium can induce teeth in nondental ectomesenchyme in both mice and birds. In addition, the deposition of Meckel's cartilage as a rod of cartilage in the middle of the first branchial arch is under the control of the epithelium. The epithelium inhibits chondrogenesis; if it is removed, large amorphous masses of cartilage are found instead of the narrow rod typical of Meckel's cartilage.
authors.affiliation: Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06032.
authors.forename: E J
authors.initials: EJ
authors.lastname: Kollar
authors.forename: M
authors.initials: M
authors.lastname: Mina
mesh_terms: D000818:Animals; D002356:Cartilage / Q000196:embryology; D003094:Collagen / Q000096:biosynthesis; D004848:Epithelium / Q000502:physiology*; D008334:Mandible / Q000196:embryology*; D008648:Mesoderm / Q000502:physiology; D051379:Mice; D014070:Tooth / Q000196:embryology*
chemical_list: D003094:Collagen