Recent treatments of aplastic anemia. The International Group on SAA.
The treatment of severe aplastic anemia has been modified recently by the demonstration that Cyclosporine A is active alone or in combination leading to more than 50% response rate. Combination or sequential treatments with ATG seem to be better than such drug separately but this must be studied in randomized studies. Long term follow-up is necessary to assess the rate of malignant transformation. Growth factors have been recently introduced. G or GM-CSF seem to be active. IL-3 has not been proven to be effective in very small non randomized study. Allogeneic bone marrow transplantation is the best treatment with a matched related donor, progress must be achieved in methods of conditioning and GVH prophylaxis when a matched unrelated donor is used.
Gluckman
E
E
Bone Marrow Transplant Unit, Hôpital Saint-Louis, Paris, France.
Espérou-Bourdeau
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H
D000741:Anemia, Aplastic / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D016572:Cyclosporine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006133:Growth Substances / Q000627:therapeutic use; D006801:Humans; D011241:Prednisone / Q000627:therapeutic use; D014019:Tissue Donors
D000961:Antilymphocyte Serum; D006133:Growth Substances; D016572:Cyclosporine; D011241:Prednisone