Cytokine- and Pneumocystis carinii- induced L-arginine oxidation by murine and human pulmonary alveolar macrophages.
Lipopolysaccharide plus interferon gamma stimulated the L-arginine-.NO pathway of murine, but not human pulmonary alveolar macrophages. Pneumocystis carinii induced .NO production by both murine and human pulmonary alveolar macrophages suggesting that the parasite stimulates L-arginine oxidation in these cells. The potential anti-Pneumocystis activity of .NO warrants further study.
Sherman
M P
MP
Department of Pediatrics, University of California, Los Angeles 90024.
Loro
M L
ML
Wong
V Z
VZ
Tashkin
D P
DP
D000818:Animals; D001120:Arginine / Q000378:metabolism*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D016676:Macrophages, Alveolar / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D011010:Pneumocystis / Q000276:immunology*
D009569:Nitric Oxide; D007371:Interferon-gamma; D001120:Arginine