[Effect of captopril on urinary 6-keto-PGF1 alpha, thromboxane B2 in inbred SHR rats].
Urinary 6-keto-PGF1 alpha, TXB2, PRA, ATII, blood pressure, urine volume, urinary sodium and potassium were measured by RIA in SHR after administration of captopril and indomethacin. The results suggested that captopril would significantly decrease ATII, and showed marked effects of hypotension, diuresis and caused variation of PG system. Urinary 6-keto-PGF1 alpha and TXB2 were significantly increased in both rat groups, but changes of TXB2/PGI2 ratio were different. The studies yet suggested indomethacin could antagonize the hypotensive effects of captopril.
Wang
L
L
Second Affiliated Hospital, Tianjin Medical College.
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine*; D000804:Angiotensin II / Q000652:urine; D000818:Animals; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006973:Hypertension / Q000188:drug therapy* / Q000652:urine; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000652:urine; D013929:Thromboxane B2 / Q000652:urine*
D000804:Angiotensin II; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D002216:Captopril; D012083:Renin