title: Micron-resolution ranging of cornea anterior chamber by optical reflectometry.
abstract: Noncontact, high resolution measurements of anterior eye structures using optical coherence domain reflectometry are described. Distances between intraocular structures are measured by directing a beam of short coherence length light onto the eye and performing an interferometric measurement on the optical group delay of reflected signals. Measurements of corneal thickness, corneal excision depth, and anterior chamber depth are demonstrated in vitro, and the location of tissue boundaries is resolved to within +/- 2 microns. The full-width-half-maximum longitudinal resolution is 10 microns. Sensitivities to reflected signals as small as 10(-10) of the incident power are achieved by heterodyne detection.
authors.affiliation: Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: D
authors.initials: D
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: C P
authors.initials: CP
authors.lastname: Lin
authors.forename: C A
authors.initials: CA
authors.lastname: Puliafito
authors.forename: J G
authors.initials: JG
authors.lastname: Fujimoto
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000033:anatomy & histology*; D001082:Aqueous Humor; D002417:Cattle; D003315:Cornea / Q000033:anatomy & histology* / Q000601:surgery; D004867:Equipment Design; D006371:Helium; D007259:Infrared Rays; D007368:Interferometry / Q000295:instrumentation / Q000379:methods; D007834:Lasers; D009356:Neon; D055095:Optics and Photonics / Q000295:instrumentation
chemical_list: D006371:Helium; D009356:Neon