[The examination of pyruvate and erythrocyte transketolase activity in the blood of patients with chronic alcoholic nervous disease].
To study the laboratory and mechanism of chronic alcoholic nervous disease (CAND), we have examined pyruvate and erythrocyte transketolase activity (E-TKA) in the blood of 20 patients with CAND with normal subjects as controls Then, they were treated with vitamin B. The results were: 1. the level of pyruvate in the blood of the patients with CANE was higher than that of the controls. The E-TKA in the blood of the patients with CAND was lower than that of the controls. There was significant difference in both the two indexes between the two groups, 2. After treatment, the syndromes of the patients were obviously relieved. The pyruvate and E-TKA in the blood of the patients returned to normal. It proves that: 1. the vitamin B in the body of the patients with CAND was lower than that of normal people. 2. the pyruvate and E-TKA in the patients' blood may be taken as laboratory indexes of the CAND. 3. The examination of E-TKA may be preclinical diagnosis to CAND. 4. CAND is mainly caused by vitamin B deficiency.
Jiang
C B
CB
Dalian Medicine College.
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011605:Psychoses, Substance-Induced / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D011773:Pyruvates / Q000097:blood*; D014174:Transketolase / Q000378:metabolism*; D014803:Vitamin B Complex / Q000627:therapeutic use
D011773:Pyruvates; D014803:Vitamin B Complex; D014174:Transketolase