Fibronectin immunoreactivity in neural trauma.
The presence of extracellular matrix protein fibronectin (FN) at the site of neural trauma was examined using immunohistochemical methods. At 2, 4 and 7 days following a penetrating wound through the rat cerebral cortex, FN staining was detected in the neuropil and in non-neuronal cells adjacent to the wound. FN-stained cells were GFAP-negative and were identified as brain macrophages based on cell surface staining for CR3 complement receptor. Our findings suggest a role for FN in the repair of neural trauma.
Egan
R A
RA
Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis 95616-8643.
Vijayan
V K
VK
D000818:Animals; D001253:Astrocytes / Q000473:pathology / Q000502:physiology; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D005353:Fibronectins / Q000032:analysis / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006984:Hypertrophy; D008264:Macrophages / Q000473:pathology / Q000502:physiology; D009474:Neurons / Q000473:pathology / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D014950:Wounds, Penetrating / Q000473:pathology / Q000503:physiopathology*
D005353:Fibronectins; D005904:Glial Fibrillary Acidic Protein