title: Induction of a class I beta-lactamase from Citrobacter freundii in Escherichia coli requires active ftsZ but not ftsA or ftsQ products.
abstract: A possible connection between septation/division and induction of cloned ampC beta-lactamase was investigated. When a ftsZ84(Ts) mutant of Escherichia coli carrying ampR-ampC from Citrobacter freundii was grown at the restrictive temperature (42 degrees C), induction of beta-lactamase by cefoxitin was inhibited by about 80%. Inhibition was virtually complete when a ftsZ84(Ts) mutant of different genetic background was tested. Although somewhat delayed, the induction of beta-lactamase in transformed ftsA(Ts) and ftsQ(Ts) mutants was similar to that observed in wild-type transformants. These results imply that FtsZ is involved in the process of beta-lactamase induction.
authors.affiliation: Department of Medical Microbiology and Immunology, Ohio State University College of Medicine, Columbus 43210.
authors.forename: A C
authors.initials: AC
authors.lastname: Ottolenghi
authors.forename: J A
authors.initials: JA
authors.lastname: Ayala
mesh_terms: D016971:Citrobacter freundii / Q000201:enzymology* / Q000235:genetics; D004790:Enzyme Induction / Q000187:drug effects; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D005838:Genotype; D010405:Penicillinase / Q000096:biosynthesis*; D010957:Plasmids
chemical_list: D010405:Penicillinase