title: [Management of intracranial vasospasm in rupture of cerebral aneurysm].
abstract: This paper describes the methods of prevention of delayed neurological deficit (DND) in patients with subarachnoid haemorrhage (SAH) due to ruptured intracranial aneurysm. To prevent the decrease in the cerebral flow, vasodilators, inhibitors of platelet aggregation and synthesis of endogenous prostaglandins, stimulators of prostacyclin synthesis of its analogue should be applied. It is also recommended to use the inhibitors of phosphodiesterase, blockers of serotonin and of calcium channel (particularly nimodipine). Therapy with the immunosuppressive drugs helps to prevent DND. With all those therapeutical methods DND is still a serious complication following SAH.
authors.affiliation: Zakładu Neurofizjologii Centrum Medycyny Doświadczalnej i Klinicznej PAN, Warszawie.
authors.forename: M
authors.initials: M
authors.lastname: Ryba
authors.forename: K
authors.initials: K
authors.lastname: Iwańska
authors.forename: M
authors.initials: M
authors.lastname: Pastuszko
mesh_terms: D002536:Cerebral Arteries / Q000187:drug effects* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D004359:Drug Therapy, Combination; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011448:Prostaglandin Antagonists / Q000008:administration & dosage; D012422:Rupture, Spontaneous; D012702:Serotonin Antagonists / Q000008:administration & dosage; D013035:Spasm / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D010975:Platelet Aggregation Inhibitors; D011448:Prostaglandin Antagonists; D012702:Serotonin Antagonists; D014665:Vasodilator Agents
vernacular_title: Postepowanie w stanach skurczu naczyń wewnatrzczaszkowych w przebiegu pekniecia tetniaka mózgu.