[Changes in hormonal and biochemical parameters in gastric adenocarcinoma].
In 51 patients with gastric adenocarcinoma the fasting blood concentrations of hCG, beta hCG, alpha subunits, ADH, calcitonin, enteroglucagon, gastrin, GH, melatonin, somatostatin, estradiol, CEA and pepsinogen I in the peripheral vein were estimated by radioimmunoassay at the time of diagnosis and, in those who underwent surgery, 7 days after the operation, to determine the incidence of the modifications of the above mentioned substances' blood levels and the existence of possible markers. In presence of increases of the examined parameters greater than 50%, considering M +/- 2 SD of 10 control subjects as normal range, the tumours were examined immunohistochemically. In patients with gastric adenocarcinoma, in comparison with normal subjects, we found significant higher blood levels of hCG alpha subunits, gastrin and CEA and lower of melatonin, pepsinogen I and GH. The immunohistological results demonstrated CEA in both examined cases, alpha subunits in 2 of 6 (respectively in dysplasic areas and in surrounding non neoplastic mucosa) and enteroglucagon in 1 of 3 (dysplasic areas). Our results indicate that none of the parameters we examined, because of their non-specificity or of the low incidence of their modifications, can be considered a marker of gastric adenocarcinoma.
Colombo
F
F
Dipartimento di Medicina Interna e Terapia Medica, II Facoltà di Medicina e Chirurgia, Università di Pavia.
Iannotta
F
F
Fachinetti
A
A
Giuliani
F
F
Cornaggia
M
M
Finzi
G
G
Mantero
G
G
Fraschini
F
F
Malesci
A
A
Bersani
M
M
D000230:Adenocarcinoma / Q000097:blood* / Q000737:chemistry / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000032:analysis; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry / Q000473:pathology; D006728:Hormones / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000097:blood* / Q000737:chemistry / Q000473:pathology
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D006728:Hormones; D009363:Neoplasm Proteins
Modificazioni di parametri ormonali e biochimici nell'adenocarcinoma gastrico.