[The effect of serotonin on the hematopoietic stem cells of the bone marrow].
Haemopoietic stem cells content and proliferative activity were studied in the bone marrow of female F1 (CBA x C57Bl6) mice after single (50 mg/kg) and chronic (0.5 mg/kg daily for 7 days) serotonin (S) injections. It is shown that 9-day and 12-day COEs contents in the bone marrow of experimental mice has been increasing for 24 h after single S injection. After chronic S injections twofold increase of 12-day COEs is observed without any increasing of 9-day COEs. Total myelokaryocyte number is increased too. The study of proliferative status by in vitro incubation of bone marrow cells with ARA-C has shown that the numbers of 9-day and 12-day COEs in S-phase have increased both after single and chronic S injections. Possible mechanisms of stimulating effect of S on bone marrow stem cells are discussed.
Nefedov
V P
VP
Nefedova
V V
VV
Kononykhina
V S
VS
Morgulis
I I
II
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D001854:Bone Marrow Cells; D002452:Cell Count / Q000187:drug effects / Q000528:radiation effects; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D003404:Creatinine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012701:Serotonin / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology; D013997:Time Factors
D004338:Drug Combinations; C014050:creatinine sulfate, serotonin drug combination; D012701:Serotonin; D003404:Creatinine
Vliianie serotonina na stvolovye krovetvornye kletki kostnogo mozga.