[Philadelphia-positive ALL with rearrangement of the 1st intron of the BCR gene].
We have studied the haematologic, cytogenetic and molecular features in a patient with Ph positive ALL. The cytogenetic study showed the presence of a Ph chromosome since diagnosis. Molecular analysis showed rearrangement within the first intron of bcr gen instead of M-bcr as in CML. This an evidence of genic fusion between c-abl oncogene and bcr gene and also show the possibility of rearrangement outside M-bcr in these patients.
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Dpto. Genética, Fundación Jiménez Díaz, Madrid.
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Benítez
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D000368:Aged; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007438:Introns; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051562:Proto-Oncogene Proteins c-bcr
D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr
LAL Ph positivo con reordenamiento en el primer intron del gen BCR.