Cross immunoreactivity of aortic kappa-2-elastin with some antibacterial antisera.
Immunological and microbial factors may lead to the formation of atherosclerotic lesions. Cross immune reactions between aortic kappa-2-elastin and antisera against some antigens of Gram-negative bacteria--Salmonella and Escherichia coli--were studied using the dot-immunobinding assay. Positive results were obtained with antisera against Salmonella AO, BO, CO, EO, HM and Escherichia coli OK(A). Among immunological mechanisms leading to atherosclerosis cross immunoreactivity of aortic antigens with antimicrobial antibodies should be taken into consideration.
Gmiński
J
J
Silesian Medical Academy, Department of Biochemistry, Katowice, Poland.
Sułkowski
P
P
Drózdz
M
M
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D001011:Aorta / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology; D003429:Cross Reactions / Q000276:immunology*; D004549:Elastin / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D011817:Rabbits; D012475:Salmonella / Q000276:immunology*; D013552:Swine
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D004549:Elastin