title: An evaluation of intrastromal injection of antifungal agents.
abstract: The effect of the intrastromal injection of a mixture of amphotericin B, miconazole, natamycin, and nystatin and the component agents alone was studied in Dutch-belted rabbits by standard bioassay. Twenty-four hours following injection, the inhibiting effect of the mixture was equivalent to that of nystatin alone. All other agents exhibited inferior activity. The intrastromal injection of this mixture appears to offer no therapeutic advantage.
authors.affiliation: Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: D M
authors.initials: DM
authors.lastname: O'Day
authors.forename: W S
authors.initials: WS
authors.lastname: Head
authors.forename: R D
authors.initials: RD
authors.lastname: Robinson
authors.forename: T E
authors.initials: TE
authors.lastname: Williams
mesh_terms: D000666:Amphotericin B / Q000493:pharmacokinetics; D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism; D002176:Candida albicans / Q000187:drug effects; D003319:Corneal Stroma / Q000378:metabolism*; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics; D007267:Injections; D008825:Miconazole / Q000493:pharmacokinetics; D010866:Natamycin / Q000493:pharmacokinetics; D009761:Nystatin / Q000493:pharmacokinetics; D011817:Rabbits
chemical_list: D000935:Antifungal Agents; D009761:Nystatin; D008825:Miconazole; D000666:Amphotericin B; D010866:Natamycin