title: Chronic intrathecal cannulation affects hypothalamic opioids depending on the technique employed.
abstract: Previous studies have shown that chronic intrathecal cannulation can interfere with the homeostasis of central opioid peptides. These results show that beta-endorphin and Met-enkephalin concentrations did not change in the hypothalamus of rats bearing a chronic cannula inserted between C8-T1 up to L3 and fixed to the processes transversus T1. These results suggest that chronically cannulated rats can be considered as normal when studying hypothalamic beta-endorphin or Met-enkephalin concentrations, and used in physiological studies, depending on the technique employed.
authors.affiliation: Université Claude Bernard, Laboratoire de Physiologie A, Faculté de Médecine Grange Blanche, Lyon, France.
authors.forename: B
authors.initials: B
authors.lastname: Dib
authors.forename: P
authors.initials: P
authors.lastname: Sacerdote
authors.forename: A E
authors.initials: AE
authors.lastname: Panerai
mesh_terms: D000818:Animals; D002404:Catheterization / Q000009:adverse effects*; D004723:Endorphins / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007278:Injections, Spinal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin / Q000378:metabolism
chemical_list: D004723:Endorphins; D004744:Enkephalin, Methionine; D001615:beta-Endorphin