title: Attenuation of anaphylactic shock and related mortality in guinea-pigs after administration of a potent protein kinase inhibitor, K252a.
abstract: We examined whether protein kinases have a role in the expression of anaphylactic shock (AS). Guinea-pigs sensitized to ovalbumin were administered i.p. saline (control) or 10 micrograms/kg K252a, a potent protein kinase inhibitor, 30 min before challenge. The development of AS and mortality was observed for the next 2 h. In the K252a-treated group the incidence of AS fell to 53% from 100%, the maximum intensity was 62% less than the control, and mortality dropped to 16% from 50% of the animals. We suggest that protein kinases are involved in the expression of AS, and that inhibitors of these enzymes may protect against the symptoms of AS and allergy.
authors.affiliation: Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Paz
authors.forename: Y
authors.initials: Y
authors.lastname: Ashkenazy
authors.forename: S
authors.initials: S
authors.lastname: Moshonov
authors.forename: G
authors.initials: G
authors.lastname: Fischer
authors.forename: D
authors.initials: D
authors.lastname: Feigel
authors.forename: F
authors.initials: F
authors.lastname: Kusniec
authors.forename: D
authors.initials: D
authors.lastname: Geltner
authors.forename: U
authors.initials: U
authors.lastname: Zor
mesh_terms: D000707:Anaphylaxis / Q000201:enzymology* / Q000517:prevention & control; D000818:Animals; D002227:Carbazoles / Q000494:pharmacology*; D006168:Guinea Pigs; D026121:Indole Alkaloids; D008297:Male; D010766:Phosphorylation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D002227:Carbazoles; D026121:Indole Alkaloids; C049985:staurosporine aglycone; D011493:Protein Kinase C