Chymotrypsin-catalyzed fragment coupling synthesis of GnRH-analogs.
D-Xaa6-GnRH analogs (Xaa: Ala, Nal1), Phe, Ser(tBu), Trp) were prepared by chymotrypsin catalyzed 3 + 7 fragment coupling synthesis with conversion rates of the amino component in the range from 90.3 to 97.4%. For D-Phe6-GnRH the method was scaled up to production level.
Hänsicke
A
A
Berlin-Chemie AG, Berlin.
Krause
E
E
Bienert
M
M
Schmidt
M
M
Kobert
S
S
Schellenberger
V
V
Jakubke
H D
HD
Kaufmann
K D
KD
D002384:Catalysis; D002918:Chymotrypsin / Q000737:chemistry; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry
D009842:Oligopeptides; D007987:Gonadotropin-Releasing Hormone; D002918:Chymotrypsin