Effect of linoleic acid hydroperoxide on production of matrix metalloproteinases by human skin fibroblasts.
The effect of linoleic acid hydroperoxide on in vitro production of matrix metalloproteinases (MMPs) by human skin fibroblasts was studied. The addition of linoleic acid hydroperoxide significantly increased the production of MMP-1 (tissue collagenase) and MMP-3 (stromelysin), while it rather decreased that of MMP-2 (gelatinase of 72 kDa; so-called "type IV collagenase"). The effect of lipid peroxides to alter collagen metabolism was discussed from pathogenic points of view.
Ohuchida
M
M
Department of Pathology, Kurume University School of Medicine, Japan.
Sasaguri
Y
Y
Morimatsu
M
M
Nagase
H
H
Yagi
K
K
D002478:Cells, Cultured; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015151:Immunoblotting; D008041:Linoleic Acids / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000494:pharmacology*; D008666:Metalloendopeptidases / Q000096:biosynthesis*; D008856:Microscopy, Fluorescence; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D008041:Linoleic Acids; D008054:Lipid Peroxides; C008285:linoleic acid hydroperoxide; D008666:Metalloendopeptidases