title: [Efficacy of a theophylline retard preparation administered at 3 different intake times additionally to basic medication].
abstract: In this randomised crossover study in 26 outpatients with bronchial asthma the efficacy of a new once-daily theophylline formulation given in addition to a baseline medication was investigated; moreover, under steady state conditions, the effect of three evening intake times (6, 8 and 10 p.m.) on 24-hour pharmacokinetics and peak-expiratory flow profiles was evaluated. The theophylline dose had been individually titrated. The pharmacodynamic results show a marked improvement in 24-hour lung function data after adding theophylline to a drug therapy including inhalative anti-cholinergics in 50% of the treated outpatients. No significant differences between the pharmacokinetic characteristics and the 24-hour averages (mesors) of peak expiratory flow at the three different intake times 6, 8 and 10 p.m. were found; however, intake at 10 p.m. resulted in the highest nocturnal excess of serum theophylline concentrations and the highest peak expiratory flow during the early morning hours between 2 and 6 a.m.
authors.affiliation: Rudolf-Virchow Universitätskliniken (Wedding), Abteilung für klinische Immunologie und Asthma-Poliklinik, Universitätsklinikum Charlottenburg, Berlin.
authors.forename: B
authors.initials: B
authors.lastname: Siebert
authors.forename: G
authors.initials: G
authors.lastname: Kunkel
authors.forename: K
authors.initials: K
authors.lastname: Borner
authors.forename: H W
authors.initials: HW
authors.lastname: Staudinger
authors.forename: A
authors.initials: A
authors.lastname: Böhm
authors.forename: V W
authors.initials: VW
authors.lastname: Steinijans
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000627:therapeutic use; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D013806:Theophylline / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D010276:Parasympatholytics; D013806:Theophylline
vernacular_title: Wirksamkeit eines zu drei verschiedenen abendlichen Einnahmezeiten zusätzlich zu einer Basismedikation gegebenen Theophyllinretardpräparates.