Morphological changes of Candida albicans induced by saperconazole.
The effects of a new triazole antifungal agent, saperconazole, on the morphology of Candida albicans were studied by scanning and transmission electron microscopy. An inoculum of 10(6) CFU ml-1 was exposed to saperconazole at 1 and 10 micrograms ml-1 and at different times up to 24 h samples were removed for microscopic observations. The antifungal agent caused the yeasts to become round and turgescent and to cluster; budding appeared to be affected also, as seen by scanning electron microscopy. Transmission electron microscopy showed a thickened wall, the presence of intraparietal electron-dense vesicles and of multilamellae near the plasma membrane.
Montès
B
B
Laboratoire d'Immunologie et Parasitologie, Faculté de Pharmacie, Montpellier, France.
Mallié
M
M
Jouvert
S
S
Bastide
J M
JM
D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning
D000935:Antifungal Agents; D001393:Azoles; C060571:saperconazole