title: Humoral transplantation antibodies play a role in protracted rejection of murine renal allografts.
abstract: Murine renal allografts were studied using (C57BL/6J x A/J)F1 mice as recipients and DBA/2 mice as donors. In this strain combination, protracted rejection was noted in that the circulation was maintained in the graft for over 10 weeks. In all grafts examined after 3 weeks, mononuclear cell infiltrates were noted; in addition, all grafts had immune deposits, apparently containing transplantation antibodies, in glomeruli, tubuli and vessels. These results stressed the role of humoral immunity in protracted renal allograft rejection.
authors.affiliation: Department of Microbiology, State University of New York, Buffalo.
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: N
authors.initials: N
authors.lastname: Niesen
authors.forename: F
authors.initials: F
authors.lastname: Milgrom
authors.forename: B
authors.initials: B
authors.lastname: Albini
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology* / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D006084:Graft Rejection; D007518:Isoantibodies / Q000276:immunology*; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D051379:Mice
chemical_list: D000936:Antigen-Antibody Complex; D007518:Isoantibodies