Structural elucidation of the 8-methoxypsoralen oxidized product that inhibits the chemotactic activity of polymorphonuclear neutrophils toward anaphylatoxin C5a.
The chemical structure of the 8-methoxypsoralen oxidized product that inhibits the chemotactic activity of anaphylatoxin C5a was determined to be 2,3-dihydro-2,9-dimethoxy-3-hydroxy-7-oxo-7H-furo[3,2-g] [1]benzopyran. Its minimal concentration required to obtain the maximum inhibition of C5a des Arg (1 x 10(-8) M) chemotactic activity is 2.5 x 10(-8) M. Bioactivity of this substance was maintained for 2 weeks, stored in a dark room at room temperature under aerobic conditions. There is a possibility that this substance may be useful in the treatment of immune complex diseases.
Mizuno
N
N
Department of Dermatology, Nagoya City University Medical School, Japan.
Esaki
K
K
Sakakibara
J
J
Murakami
N
N
Nagai
S
S
D002634:Chemotaxis, Leukocyte / Q000502:physiology* / Q000528:radiation effects; D015936:Complement C5a / Q000494:pharmacology*; D006801:Humans; D008730:Methoxsalen / Q000737:chemistry* / Q000378:metabolism; D009504:Neutrophils / Q000502:physiology* / Q000528:radiation effects; D010084:Oxidation-Reduction
D015936:Complement C5a; D008730:Methoxsalen