title: Patent ductus arteriosus increases lung fluid filtration in preterm lambs.
abstract: Previous studies showed that increased pulmonary blood flow from a patent ductus arteriosus had little or no effect on the amount of fluid in the lungs of mechanically ventilated preterm lambs. The purpose of this study was to examine the effect of a patent ductus arteriosus on lung vascular permeability and to see whether increased pulmonary lymph flow might compensate for the increased rate of fluid filtration. Using a model that allows mechanical control of ductus patency, we studied the effects of increased pulmonary blood flow on lung vascular pressures in six mechanically ventilated premature lambs at 136 +/- 2 d gestation (mean +/- SD) (term = 145 d). We measured lung lymph flow and protein concentrations in lymph and plasma to assess pulmonary vascular fluid filtration and protein permeability. We studied each lamb during sequential steady state periods, first with the ductus open and then with it closed. When the ductus was open, pulmonary blood flow was twice what it was when the ductus was closed. Mean pulmonary artery pressure and left ventricular end-diastolic pressure were greater with the ductus open [40 +/- 5 torr (5.3 +/- 0.7 kPa) and 8 +/- 3 torr (1.1 +/- 0.4 kPa), respectively] than when it was closed [24 +/- 3 torr (3.2 +/- 0.4 kPa) and 4 +/- 2 torr (0.5 +/- 0.3 kPa), respectively]. When the ductus was open, lymph flow was 68% greater and lymph protein concentration was 17% lower than when the ductus was closed. Lymph protein clearance (lymph flow x lymph protein concentration/plasma protein concentration) was 39% greater when the ductus was open.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Cardiovascular Research Institute, University of California, San Francisco 94143.
authors.forename: G
authors.initials: G
authors.lastname: Alpan
authors.forename: R
authors.initials: R
authors.lastname: Scheerer
authors.forename: R
authors.initials: R
authors.lastname: Bland
authors.forename: R
authors.initials: R
authors.lastname: Clyman
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001826:Body Fluids / Q000502:physiology; D002199:Capillary Permeability; D004374:Ductus Arteriosus, Patent / Q000503:physiopathology*; D005260:Female; D008168:Lung / Q000503:physiopathology*; D008196:Lymph / Q000502:physiology; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism; D011652:Pulmonary Circulation; D012121:Respiration, Artificial; D012756:Sheep; D014882:Water-Electrolyte Balance
chemical_list: D011506:Proteins