Hepatitis E virus genome. Molecular features, expression of immunoreactive proteins and sequence divergence.
The strategy for molecular cloning of hepatitis E virus (HEV), the major etiologic agent of enterically-transmitted non-A, non-B hepatitis, is briefly described. The organization of the HEV genome is discussed and compared to those of two other vertebrate viruses that contain single-stranded, positive-sense, polyadenylated RNA genomes with three overlapping ORFs. Serologic cross-reactivity of expressed proteins and genetic divergence of HEV isolates are also described within the context of sequence variation, type-common epitopes, and type-specific epitopes.
Bradley
D W
DW
Centers for Disease Control, Atlanta, GA 30333.
Purdy
M A
MA
Reyes
G R
GR
D003001:Cloning, Molecular; D014644:Genetic Variation; D016679:Genome, Viral; D016752:Hepatitis E virus / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D012367:RNA, Viral / Q000235:genetics
D012367:RNA, Viral