Studies on the hypothalamus and secretory nuclei of rat in the remote period following clinical death.
Ultrastructural studies of hypothalamic secretory nuclei were carried out on rats which survived 16 weeks after 5- or 10-min-long clinical death. Active neurosecretory cells were noted without any signs of injury. In perikaryonic area numerous polymorphic lysosomes and "nucleolus-like bodies" were observed. Attention was called to significant changes in the structure of cytoskeleton and observations were discussed in relation to biochemical data. In both groups of the studied animals neurosecretory cells with features of apoptosis were found. Apoptotic cells appeared more often in animals which survived 10-min-long clinical death. Characteristic morphological features of the process of apoptosis are shown in illustrations.
Walski
M
M
Laboratory of the Ultrastructure of the Nervous System, Medical Research Centre, Polish Academy of Sciences, Warsaw.
Celary-Walska
R
R
Borowicz
J
J
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology; D002466:Cell Nucleolus / Q000648:ultrastructure; D003599:Cytoskeleton / Q000648:ultrastructure; D003643:Death; D006323:Heart Arrest / Q000473:pathology; D007031:Hypothalamus / Q000473:pathology / Q000648:ultrastructure*; D008247:Lysosomes / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012151:Resuscitation