The normocomplementemic urticarial vasculitis syndrome--report of a case and response to colchicine.
A patient with a 15-year history of urticarial vasculitic rashes and chronic vasculitic skin ulceration has been followed at our Connective Tissue Disease Clinic for the past five years. Serum complement levels have been persistently normal. She has been unresponsive to a variety of medications including steroids, dapsone and hydroxychloroquine. She had a dramatic response to colchicine 500 micrograms daily with total clearing of the urticarial vasculitic rash.
Asherson
R A
RA
Department of Rheumatology, St Thomas' Hospital, London, UK.
Buchanan
N
N
Kenwright
S
S
Fletcher
C M
CM
Hughes
G R
GR
D002908:Chronic Disease; D003078:Colchicine / Q000627:therapeutic use*; D003165:Complement System Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D013577:Syndrome; D014581:Urticaria / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D014657:Vasculitis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology
D003165:Complement System Proteins; D003078:Colchicine