Effect of exogenous ascorbic acid on experimental hypertension and mineral balance in rats fed low- and high-fat diets.
The effects of exogenous ascorbic acid on the development of experimental hypertension and on calcium, sodium, and potassium metabolism have been studied. The investigation was carried out in 90 4-mo-old male Wistar rats fed high- and low-fat diets. Hypertension was induced by administering a 1.5% solution of NaCl orally. Some rats received 0.1% ascorbic acid in distilled water orally for the first 7 wk of the experiment, then 0.3% for the next 5 wk. The results showed that the amount of fat, NaCl, and ascorbate in the diet may play a role in the etiopathogenesis of hypertension. A high-fat high-NaCl diet increased blood pressure more than a low-fat high-NaCl diet. Additional intake of 0.3% ascorbate solution reduced experimentally induced hypertension by 4% with a low-fat diet and by 14% with a high-fat diet. Also, 0.3% ascorbate solution had a blood-pressure-lowering effect in rats fed a high-fat diet without NaCl. Supplementation with ascorbate diminished urine calcium output with a high-fat diet and increased the urine PGE2/PGF2 ratio with both low- and high-fat diets.
Ziemlański
S
S
Department of Nutrition Physiology and Biochemistry, National Food and Nutrition Institute, Warsaw, Poland.
Wartanowicz
M
M
Potrzebnicka
K
K
Burgos de Moor
A
A
Iwanow
K
K
Ignatowska-Switalska
M
M
Zelakiewicz
K
K
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D002118:Calcium / Q000652:urine; D004041:Dietary Fats / Q000008:administration & dosage*; D015237:Dinoprost / Q000652:urine; D015232:Dinoprostone / Q000652:urine; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage
D004041:Dietary Fats; D012965:Sodium Chloride; D015237:Dinoprost; D015232:Dinoprostone; D001205:Ascorbic Acid; D002118:Calcium