Anti-aldosteronergic effect of torasemide.
The diuretic actions of torasemide and furosemide were studied in normotensive rats and in deoxycorticosterone acetate (DOCA)-saline-loaded hypertensive rats. Torasemide (0.3-3 mg/kg) and furosemide (3-30 mg/kg) had a dose-dependent and significant diuretic action in normotensive rats. Potassium retention was only observed in the case of torasemide. Torasemide also had a dose-dependent and significant diuretic action in DOCA-saline-loaded hypertensive rats, whereas furosemide did not. Higher doses of torasemide (10 mg/kg) and furosemide (100 mg/kg) increased both plasma renin activity and aldosterone concentration in normotensive rats in a similar manner. In vivo aldosterone receptor binding was determined to test the possible anti-aldosteronergic effect of torasemide. Torasemide inhibited the binding of aldosterone to its receptor in the cytoplasmic fraction of rat kidney in a dose-dependent manner, while furosemide produced no effect. These results suggest strongly that an anti-aldosteronergic action of torasemide contributes to producing less kaliuresis.
Uchida
T
T
Central Research Laboratory, Green Cross Corporation, Osaka, Japan.
Yamanaga
K
K
Nishikawa
M
M
Ohtaki
Y
Y
Kido
H
H
Watanabe
M
M
D000284:Administration, Oral; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D013449:Sulfonamides / Q000494:pharmacology*; D000077786:Torsemide
D004232:Diuretics; D013449:Sulfonamides; D000450:Aldosterone; D005665:Furosemide; D012083:Renin; D000077786:Torsemide