title: Rapid appearance of beta-amyloid precursor protein immunoreactivity in damaged axons and reactive glial cells in rat brain following needle stab injury.
abstract: Brains of rats that had received needle stab wounds were examined sequentially for 72 h by immunohistochemistry using antibodies to beta-amyloid precursor protein (APP). Immunoreactivity appeared 0.5 h after the injury in axons adjacent to the needle tract, becoming stronger over 15 h in neighboring swollen axons. APP-immunoreactive glial cells appeared 6 h after the injury around the needle tract and persisted throughout the experiment. Morphologically, these cells were thought to be mainly astrocytes.
authors.affiliation: Department of Neuropathology, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Otsuka
authors.forename: M
authors.initials: M
authors.lastname: Tomonaga
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000648:ultrastructure; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D003337:Corpus Callosum / Q000473:pathology / Q000503:physiopathology; D009339:Needles; D009457:Neuroglia / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D014951:Wounds, Stab / Q000473:pathology / Q000503:physiopathology*
chemical_list: D016564:Amyloid beta-Protein Precursor