title: [Paracoccidioidomycosis of intramedullar and cerebral localization].
abstract: It is reported our diagnosis and therapeutical experience with a patient that presented clinical, radiological and tomographical manifestations of paracoccidioidomycosis with involvement of lungs, brain and spinal cord. Besides being a rare case the authors call attention for the extreme difficulty in defining the final diagnosis, which was achieved only after laminectomy and surgical biopsy of the intra spinal cord tumor at the C5 level. The patient received two series of treatment with ketoconazole (400-600 mg/day). After both the patient presented tonic and clonic convulsive disorders. We speculated about a possible perigranulomatous inflammatory response related to the therapeutical intervention, not yet described in literature.
authors.affiliation: Hospital das Doenças do Aparelho Locomotor/Sarah, Brasília, Brasil.
authors.forename: R N
authors.initials: RN
authors.lastname: Morato-Fernandez
authors.forename: P S
authors.initials: PS
authors.lastname: Beraldo
authors.forename: M
authors.initials: M
authors.lastname: Masini
authors.forename: P H
authors.initials: PH
authors.lastname: Costa
mesh_terms: D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010229:Paracoccidioidomycosis / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D007654:Ketoconazole
vernacular_title: Paracoccidioidomicose de localização intramedular e cerebral.