title: [Production of slime by coagulase-negative staphylococci as a marker of systemic infection in newborn infants].
abstract: We studied 310 strains of Staphylococcus spp. from neonates admitted in intensive care unit from june 1988 to may 1990, with the purpose of establishing a relationship between the slime production and the occurrence of sepsis. The original technique for its determination was modified; this facilitated the performance and the reading of results. Of 105 neonates with isolation in blood, spinal fluid and/or intravascular catheter of negative-coagulase Staphylococcus (CNS), the incidence of sepsis was 57.9% when the strain was a slime-producer, and only 11.6% when the strain did not produce slime (p less than 0.001). The risk of infection was five-fold increased when the isolated was slime-producer CNS. We proved a high predictive value when the strains were identical and isolated from two samples, one of which was blood. These results show that the production of slime is a factor which strongly support the diagnosis of neonatal sepsis due to negative-coagulase Staphylococcus.
authors.affiliation: Servicio de Neonatología, Hospital Universitario de Maternidad y Neonatología, Universidad Nacional de Córdoba, Argentina.
authors.forename: L S
authors.initials: LS
authors.lastname: Wolff
authors.forename: E
authors.initials: E
authors.lastname: Orchansky
authors.forename: M G
authors.initials: MG
authors.lastname: Jiménez
authors.forename: R W
authors.initials: RW
authors.lastname: Paolasso
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis*; D015415:Biomarkers; D001769:Blood / Q000382:microbiology; D002408:Catheters, Indwelling; D002555:Cerebrospinal Fluid / Q000382:microbiology; D003030:Coagulase / Q000032:analysis; D004866:Equipment Contamination; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012306:Risk; D018805:Sepsis / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000382:microbiology; D013210:Staphylococcus / Q000201:enzymology / Q000302:isolation & purification / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D015415:Biomarkers; D003030:Coagulase; D011135:Polysaccharides, Bacterial
vernacular_title: Producción de limo (slime) por estafilococos coagulasa-negativa como marcador de infección sistémica en neonatos.