[A study on the immunology and etiology of platinum induced asthma].
Two platinum (Pt) refinery workers with work related asthma was reported. The serum specific IgE and skin test for Pt antigen were positive. Ten guinea pigs were immunized with Pt-BSA conjugates employing CFA or AHG adjuvant via intraperitoneal. After 5-8 weeks, 33.3% of the sensitized animals experienced asthma attacks after a Pt-HSA challenge. The dynamic ventilation pulmonary imaging with 99mTc-DTPA showed a central accumulation of radioactivity. A specific IgE and IgG type antibodies were developed in 66.7% of sensitized animals by PCA test. Results of these suggested that platinum complex salt have antigenic specify. Allergic response play an important role in the mechanism of Pt induced asthma.
Liu
J Y
JY
Research Center of Occupational Medicine, Third Hospital of Beijing Medical University.
D000328:Adult; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000941:Antigens; D001249:Asthma / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008669:Metallurgy; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000276:immunology*; D010984:Platinum / Q000009:adverse effects* / Q000276:immunology; D011877:Radionuclide Imaging; D012882:Skin Tests; D016284:Technetium Tc 99m Pentetate
D000906:Antibodies; D000941:Antigens; D010984:Platinum; D016284:Technetium Tc 99m Pentetate