Chronotherapy in coronary heart disease: comparison of two nitrate treatments.
The purpose of this study was to assess the ischemic burden and the hemodynamic changes during daily activities in patients with coronary heart disease. Three exercise tests were performed during the day (10:00 a.m., 2:00 p.m., 6:00 p.m.), recording ST-segment depression, pulmonary artery pressure, pulmonary wedge pressure, and cardiac output as well as heart rate and systemic blood pressure during placebo and nitrate therapy. With placebo as well as nitrate therapy there was a gradual increase of ischemia and preload and a decrease of cardiac output during the day. High nitrate concentrations led to a significant reduction of both preload and ST depression with a marked circadian phase dependency of cardiovascular effects.
Wortmann
A
A
Medical University Clinic II, University Erlangen-Nürnberg, Germany.
Bachmann
K
K
D000368:Aged; D002940:Circadian Rhythm / Q000502:physiology; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004562:Electrocardiography; D015444:Exercise / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood; D008297:Male; D008875:Middle Aged
D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate