title: Metabolic changes induced by w-3 polyunsaturated fatty acid rich-diet (w-3 PUFA) on the thymus, spleen and mesenteric lymph nodes of adult rats.
abstract: The maximal activity of key enzymes of glycolysis, pentose phosphate pathway, TCA cycle and glutaminolysis were measured in the immune tissues of rats fed w-3 PUFA during 6 weeks. Total lipid peroxidation and glutathione peroxidase activity were also measured. The hexokinase activity was enhanced 4-fold in the spleen and thymus, doubled in the liver and was diminished in mesenteric lymph nodes (35%). Citrate synthase activity was decreased in the spleen and lymph nodes and increased in the thymus. G-6-PDH activity was increased 2-fold in the spleen and mesenteric lymph nodes and by 20% in the thymus whereas it was reduced (66%) in the liver. Glutathione peroxidase activity and total lipid peroxides increased in all tissues of rats fed w-3 PUFA. The results presented here suggest that w-3 PUFA, by causing important metabolic changes in the immune tissues and lipid peroxidation may lead to changes of immune function.
authors.affiliation: Department of Physiology and Biophysics, São Paulo University, Brazil.
authors.forename: A R
authors.initials: AR
authors.lastname: Guimarães
authors.forename: R
authors.initials: R
authors.lastname: Curi
mesh_terms: D000818:Animals; D002952:Citric Acid Cycle / Q000187:drug effects; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008198:Lymph Nodes / Q000187:drug effects / Q000378:metabolism; D008208:Lymphatic System / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008297:Male; D010427:Pentose Phosphate Pathway / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism
chemical_list: D015525:Fatty Acids, Omega-3