[Evaluation of the reproductive endocrine system in a population of hemodialyzed adult males].
There is a high incidence of sexual disorders of multifactorial origin in hemodialysed patients. The endocrine reproduction system was evaluated in 19 male adult hemodialysed patients. Slightly enhanced levels of prolactin and gonadotropins were found together with normal levels of total and free testosterone. Androgen biosynthesis intermediates were substantially normal. Hypophyseal stimulation tests using TRH and GnRH revealed a prolactin and gonadotropins response which was reduced, slow and protracted compared to normal. Hypophyseal stimulation did not cause any variation in testosterone levels. Prolactin and gonadotropins were not pulsatile. Data obtained appear to indicate that the hormonal component in sexual disorders in uremic patients is related to dynamic alterations of the system rather than basic hormonal changes.
Odone
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Divisione di Nefrologia e Dialisi, Ospedale Civile di Alessandria.
Ortensia
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A
Boccalatte
G
G
Rosti
G
G
Tafuri
A
A
D000328:Adult; D000368:Aged; D000728:Androgens / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010908:Pituitary Hormones, Anterior / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects; D012735:Sexual Dysfunction, Physiological / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D013973:Thyrotropin-Releasing Hormone
D000728:Androgens; D010908:Pituitary Hormones, Anterior; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone
Valutazione dell'assetto endocrino riproduttivo in una popolazione di maschi adulti emodializzati.