Autoantibody formation after bone marrow transplantation: a comparison between autologous and allogeneic grafts.
Various autoantibodies were screened in 11 allogeneic, 14 autologous bone marrow transplanted patients and 11 healthy controls. Except anti-mitochondria antibodies, autoantibodies were found with similar frequencies after allogeneic and autologous transplantation. Moreover, 50% of autoantibodies were already present before transplantation. These results suggest that factors other than allogeneic reaction could be responsible for autoantibody formation after bone marrow transplantation, in particular, pre-graft conditioning treatment and/or viral and bacterial infection. Nevertheless, the number of patients with 2 or more autoantibodies was significantly higher after allogeneic than after autologous grafting (respectively, 82% and 36.7%; p less than 0.05). Forty percent of allografted but none of autografted patients were still positive at 12 months post graft. So, allogeneic reaction could play a role in intensity of humoral response and its maintenance for a long period.
Sanmarco
M
M
Laboratoire d'Immunologie, Faculté de Médecine, Marseille.
Vialettes
B
B
Maraninchi
D
D
Bernard
D
D
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000974:Antibodies, Antinuclear / Q000096:biosynthesis; D000917:Antibody Formation; D001323:Autoantibodies / Q000032:analysis*; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology*; D002648:Child; D005260:Female; D005455:Fluorescent Antibody Technique; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology; D007951:Leukemia, Myeloid / Q000276:immunology; D008297:Male; D008928:Mitochondria / Q000276:immunology; D009101:Multiple Myeloma / Q000276:immunology; D009130:Muscle, Smooth / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology; D012737:Sex Factors; D014182:Transplantation, Autologous / Q000276:immunology*; D014184:Transplantation, Homologous / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies