Association of autoimmunity and cicatricial pemphigoid: is there an immunogenetic basis?
A group of 34 patients with cicatricial pemphigoid was investigated for the presence of autoimmune disorders. Thirty-two percent of patients had autoimmune disease compared with 7% in the control population, a highly significant difference (p less than 0.002). Circulating autoantibodies were also significantly more common in patients (p less than 0.05). Twenty-four patients with cicatricial pemphigoid were typed for HLA. A statistically significant increase in the frequency of DR4 and DQw3 antigens was observed in these patients. These findings suggest a possible genetic basis for the autoimmune association and predisposition for development of cicatricial pemphigoid.
Nayar
M
M
Department of Dermatology, Slade Hospital, Oxford, England.
Wojnarowska
F
F
Venning
V
V
Taylor
C J
CJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000752:Anemia, Pernicious / Q000150:complications; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications; D016022:Case-Control Studies; D005260:Female; D006683:HLA-DQ Antigens / Q000032:analysis; D015804:HLA-DR4 Antigen / Q000032:analysis; D006801:Humans; D007125:Immunogenetics; D008297:Male; D008875:Middle Aged; D010390:Pemphigoid, Benign Mucous Membrane / Q000276:immunology*; D012867:Skin / Q000276:immunology
D001323:Autoantibodies; D006683:HLA-DQ Antigens; C051569:HLA-DQ3 antigen; D015804:HLA-DR4 Antigen