First-order and pseudo-first-order elimination kinetics.
There is evidence that, for a number of chemicals, the elimination characteristics during bioconcentration do not follow monophasic first-order kinetics. In the first part of the present communication, a simple mathematical formula is presented that allows a clear-cut distinction between monophasic (pseudo-) and first-order and morephasic or higher-order elimination processes. The second part gives the mathematical description of a simple monophasic pseudo-first-order two-compartment model, which allows a quantitative kinetic analysis in the case of both initial compound and metabolite elimination.
Schüürmann
G
G
D000818:Animals; D002722:Chlorobenzenes / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D005399:Fishes; D006581:Hexachlorobenzene / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D013329:Structure-Activity Relationship; D015262:Xenobiotics / Q000378:metabolism* / Q000633:toxicity
D002722:Chlorobenzenes; D015262:Xenobiotics; C036720:trichlorobenzene; D006581:Hexachlorobenzene