Oral yeasts, mucosal health, and drug use in an elderly denture-wearing population.
Drug use among the elderly may be a factor in oral mucosal pathology and the prevalence of oral yeasts. This study was designed to evaluate the relationship between oral yeast, denture-bearing mucosal health and drug use, especially drugs with known hyposalivatory side effects. There was an inverse relationship between denture-bearing mucosal health, and hyposalivatory drug use r = -0.41 P less than 0.04. Use of drugs with a hyposalivatory side effect was related to increased numbers of Candida glabrata but not Candida albicans in saliva and at denture stomatitis and denture sore sites.
Kreher
J M
JM
Department of Prosthodontics, Eastman Dental Center, Rochester, NY.
Graser
G N
GN
Handelman
S L
SL
Eisenberg
A D
AD
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002175:Candida / Q000302:isolation & purification*; D016321:Dental Care for Aged; D003824:Denture, Complete / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D009055:Mouth / Q000382:microbiology; D009061:Mouth Mucosa / Q000382:microbiology; D012463:Saliva / Q000382:microbiology; D013282:Stomatitis, Denture / Q000382:microbiology* / Q000473:pathology; D014987:Xerostomia / Q000139:chemically induced*