Synthesis and study of antiprotozoal activity of some 5-nitrothiophene aldimines.
This paper reports on the synthesis and the antiparasitical activity of some 5-nitrothiophene aldimines variously substituted on aniline nucleus. The influence of substituents on the activity of the prepared compounds is discussed.
Tedlaouti
F
F
Laboratoire de Parasitologie, Faculté de Pharmacie de Merseille, France.
Gasquet
M
M
Delmas
F
F
Majester
B
B
Timon-David
P
P
Madadi
N
N
Vanelle
P
P
Maldonado
J
J
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004748:Entamoeba histolytica / Q000187:drug effects; D056890:Eukaryota / Q000187:drug effects; D007097:Imines / Q000138:chemical synthesis* / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014246:Trichomonas vaginalis / Q000187:drug effects
D000981:Antiprotozoal Agents; D007097:Imines; D013876:Thiophenes