title: Diameter and wall thickness recording of canine pylorus with implantable miniature ultrasonic transducers.
abstract: Outer diameter and thickness of the muscular wall of canine pylorus were measured simultaneously by determining the distance between pairs of implanted ultrasonic transducers, evaluating the sonic transit time with a digital sonometer. For the study of the motility in the gastroduodenal transit zone, the ultrasonically determined pyloric responses were compared with signals from conventional strain-gauge transducers sutured to the neighboring duodenum and gastric antrum. After stimulation of the gastrointestinal motility by an intravenous bolus injection of cholecystokinin octapeptide, pyloric contractions with a frequency of 5.2 min-1 could be recorded for some minutes; those contractions were independent of the more rapid antral and duodenal motility. Together with the observed tonic constriction of the pyloric ring, which could be inhibited by intravenous injection of adrenaline, an autonomous role of the gastroduodenal junction as a true sphincter is supported.
authors.affiliation: Department of Physiology, University of Marburg, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Mandrek
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008297:Male; D011708:Pylorus / Q000000981:diagnostic imaging* / Q000187:drug effects; D012844:Sincalide / Q000494:pharmacology; D014159:Transducers; D014463:Ultrasonography / Q000295:instrumentation*
chemical_list: D012844:Sincalide