title: A mammalian in vitro model to study gangliogenesis from neural crest cells.
abstract: In spite of considerable advances towards understanding lineages derived from neural crest cells using amphibian and avian embryos, the molecular mechanisms involved in the formation of mammalian peripheral ganglia remain largely unknown, mainly because of the lack of experimental systems that will allow their in vitro manipulation. Here, we present a novel mammalian in vitro model permitting to study gangliogenesis from neural crest cells. This model allowed us to manipulate molecules involved in cell-cell interactions. Our data are in favour of the existence of a hierarchy among adhesion molecules.
authors.affiliation: Laboratoire de Neurobiologie Cellulaire et Moléculaire, CNRS, Gif-sur-Yvette.
authors.forename: S
authors.initials: S
authors.lastname: Boisseau
authors.forename: V
authors.initials: V
authors.lastname: Poirier
authors.forename: O
authors.initials: O
authors.lastname: Semonin
authors.forename: L
authors.initials: L
authors.lastname: Leconte
authors.forename: M
authors.initials: M
authors.lastname: Santha
authors.forename: C
authors.initials: C
authors.lastname: Poujeol
authors.forename: G
authors.initials: G
authors.lastname: Rougon
authors.forename: M
authors.initials: M
authors.lastname: Simonneau
mesh_terms: D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology; D005724:Ganglia / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D066298:In Vitro Techniques; D051379:Mice; D008959:Models, Neurological; D009432:Neural Crest / Q000166:cytology* / Q000502:physiology; D009439:Neuraminidase / Q000378:metabolism; D010525:Peripheral Nerves / Q000196:embryology / Q000502:physiology
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D009439:Neuraminidase