[Therapy in the cardiodepressive action of bacterial and toxic shock using the regulatory opioid peptide dalargin in rats].
The author studied the effect of Dalargin, a synthetic analogue of endogenous ligands of leu-enkephalin opiate receptors, on the functional condition of a perfused isolated heart of male Wistar rats with acute staphylococcal intoxication induced by alpha-toxin and a live Staphylococcus aureus culture. All the studied indices of heart activity were reduced in the rats of the control group and subsequent perfusion of the heart in a working regime (with a functioning left ventricle) did not remove the cardiodepressive effect of the intoxication. In animals given Dalargin inhibition of functional activity in the same periods did not occur. Besides preventing disorders of cardiac activity. Dalargin caused a marked cardiotropic effect in the system in vitro when it was added to the perfusate in the isolated heart of rats with an already developed toxic or bacterial shock--restoration of myocardial functional values was encountered.
Pashutin
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D000818:Animals; D004353:Drug Evaluation, Preclinical; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004768:Enterotoxins; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006331:Heart Diseases / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D012772:Shock, Septic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013211:Staphylococcus aureus
D004768:Enterotoxins; C026066:enterotoxin A, Staphylococcal; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Terapiia kardiodepressivnogo deĭstviia bakterial'nogo i toksicheskogo shoka reguliatornym opioidnym peptidom dalarginom u krys.