title: Influence of therapy with recombinant erythropoietin on serum levels of neopterin in hemodialyzed subjects.
abstract: The authors wished to investigate some aspects of the cell-mediated immunity in hemodialyzed subjects undergoing a treatment with recombinant erythropoietin (rHuEPO). The study was carried out through the dosage of the serum levels of neopterin, a substance produced by the macrophages and usable as a marker of their state of activation. The results show a significant reduction of the serum levels of pteridine already at the second month of treatment with rHuEPO (61 +/- 9 vs. 95 +/- 12 nmol/l), thus proving a probable inhibitory action carried out by erythropoietin on certain cells of the immune system.
authors.affiliation: Chair of Nephrology II, Messina University, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Buemi
authors.forename: A
authors.initials: A
authors.lastname: Allegra
authors.forename: C
authors.initials: C
authors.lastname: Aloisi
authors.forename: N
authors.initials: N
authors.lastname: Frisina
mesh_terms: D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D011994:Recombinant Proteins / Q000627:therapeutic use; D006435:Renal Dialysis
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin; D001708:Biopterins; D019798:Neopterin