title: Characterization of a polysaccharide having activity on the reticuloendothelial system from the stolon of Glycyrrhiza glabra var. glandulifera.
abstract: An acidic polysaccharide, named glycyrrhizan GA, was isolated from the stolon of Glycyrrhiza glabra L. var. glandulifera Reg. et Herd. It produced a single band on electrophoresis and a single peak on gel chromatography, and its molecular mass was estimated to be 85,000. Glycyrrhizan GA is composed of L-arabinose: D-galactose: L-rhamnose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 22:10:1:2:1, in addition to small amounts of O-acetyl groups. Part of the hexuronic acid residues exist as methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated that its structural features include mainly alpha-arabino-beta-3,6-galactan type structural units. Glycyrrhizan GA showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test.
authors.affiliation: Kyoritsu College of Pharmacy, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Tomoda
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: R
authors.initials: R
authors.lastname: Gonda
authors.forename: N
authors.initials: N
authors.lastname: Ohara
mesh_terms: D000818:Animals; D006035:Glycyrrhiza / Q000737:chemistry*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012157:Mononuclear Phagocyte System / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D010946:Plants, Medicinal; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D011134:Polysaccharides