Distribution of 14C-ochratoxin A and 14C-ochratoxin B in rats: a comparison based on whole-body autoradiography.
The distribution patterns of ochratoxin A and its nontoxic dechloro-analogue ochratoxin B were studied in rats using whole-body autoradiography. No prominent difference in distribution patterns was found that could explain why the rat is the animal most susceptible to ochratoxin A-induced renal cancer or why ochratoxin B is less toxic than ochratoxin A.
Breitholtz Emanuelsson
A
A
Department of Biochemistry and Biotechnology, Royal Institute of Technology, Stockholm, Sweden.
Fuchs
R
R
Hult
K
K
Appelgren
L E
LE
D000818:Animals; D001345:Autoradiography; D002855:Chromatography, Thin Layer; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D009793:Ochratoxins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism; D014018:Tissue Distribution
D009793:Ochratoxins; C025589:ochratoxin A; C045354:ochratoxin B