[The effect of DOPA on segmental reflexes in rat pups].
In acute experiments on spinal 5-30-day rat puppies, studies have been made of the effect of DOPA (100 mg/kg intraperitoneally) on monosynaptic reflex in extensors (evaluated by parameters of H-reflex) as well as on polysynaptic segmentary reflexes. In 5-7-day animals, mainly the inhibitory effect was observed with a short phase of facilitation of monosynaptic reflex. From the 10th day, facilitatory effect of DOPA becomes a predominant one reaching maximum to the 16th day. Within first 16 days of postnatal life, DOPA exhibits facilitatory effect on short-latent polysynaptic reflexes and inhibits long-latent ones. To the 30th day, reactions which are typical of adult animals are observed: inhibition of short-latent and facilitation of long-latent polysynaptic discharges. The data obtained indicate that in early postnatal development the effect of DOPA on mono- and polysynaptic reflexes qualitatively differs from that in adult animals.
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D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D003655:Decerebrate State / Q000503:physiopathology; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D006181:H-Reflex / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012018:Reflex / Q000187:drug effects* / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D004295:Dihydroxyphenylalanine
Vliianie DOFA na segmentarnye refleksy u krysiat.