(-)-Grandisin form Cryptocarya crassinervia.
The known lignan (-)-grandisin [1] has been isolated from Cryptocarya crassinervia by using the brine shrimp lethality test to direct the isolation; its structure and relative stereochemistry have been determined by ir, 1H nmr, ms, and X-ray crystallography as an all-trans alpha, alpha'-diaryl-beta, beta'-dimethyltetrahydrofuran. Compound 1 is not significantly cytotoxic in our panel of human tumor cells.
Saad
J M
JM
Department of Biochemistry, University of Malaya, Kuala Lumpur, Malaysia.
Soepadamo
E
E
Fang
X P
XP
McLaughlin
J L
JL
Fanwick
P E
PE
D000818:Animals; D001156:Artemia / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D017705:Lignans; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction
D005663:Furans; D017705:Lignans; C074346:grandisin