Determination of metoclopramide in the serum and urine of cattle.
Metoclopramide, a dopamine-2 agent, has been shown to be useful in the antagonism of fescue toxicosis in grazing steers. The determination of this drug is described for the purpose of pharmacokinetic study and consideration of potential delivery devices to combat this economically significant condition.
Jones
R D
RD
Department of Veterinary Physiology and Pharmacology, University of Georgia, Athens 30602.
Bowen
J M
JM
D000085:Acetates; D000821:Animal Feed; D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D008787:Metoclopramide / Q000097:blood* / Q000627:therapeutic use / Q000652:urine*; D010939:Plant Poisoning / Q000097:blood / Q000652:urine / Q000662:veterinary*; D006109:Poaceae
D000085:Acetates; D008787:Metoclopramide; C018824:ammonium acetate