Penicillium aurantiogriseum-induced, persistent renal histopathological changes in rats; an experimental model for Balkan endemic nephropathy competitive with ochratoxin A.
Renal histopathological changes in rats, caused by food partially moulded by a common fungus isolated from an area of nephropathy in Yugoslavia, were differentiated into acute and chronic responses. The acute response to a few days on the diet specifically involved necrosis and concomitant mitosis in proximal tubule cells. More protracted, continuous or intermittent administration of nephrotoxic mould led to a marked karyomegaly in the same corticomedullary region. The phenomenon is more prominent than that induced by treatment with ochratoxin A over a similar period, raising the question of the putative role of such mycotoxins in the etiology of chronic human renal disease.
Mantle
P G
PG
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom.
McHugh
K M
KM
Adatia
R
R
Heaton
J M
JM
Gray
T
T
Turner
D R
DR
D000208:Acute Disease; D000821:Animal Feed; D000818:Animals; D001449:Balkan Nephropathy; D002908:Chronic Disease; D004195:Disease Models, Animal; D005285:Fermentation; D015726:Giant Cells / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000473:pathology; D008938:Mitosis; D009183:Mycotoxins / Q000096:biosynthesis / Q000633:toxicity*; D009336:Necrosis; D009793:Ochratoxins / Q000633:toxicity*; D010407:Penicillium / Q000502:physiology*; D051381:Rats; D014908:Triticum / Q000382:microbiology
D009183:Mycotoxins; D009793:Ochratoxins; C025589:ochratoxin A