Reduction of saturated derivatives of testosterone by a strain of Aphanocladium album.
A strain of Aphanocladium album was found to reduce carbonyl group at C-3 in 5 alpha- and 5 beta-dihydroderivatives of testosterone and androstendione. Stereochemistry of this reduction depends on the geometry of ring junction as well as on the presence of substituents (CH3 at C-4, OAc at C-17, or OH at C-19). The simultaneous presence of both CH3 at C-4 and OAc at C-17 inhibits the reduction totally in both 5 alpha- and 5 beta-isomer. The substrates containing a carbonyl group at C-17 were reduced to 17 beta-alcohol.
Dmochowska-Gładysz
J
J
Agricultural University of Wrocław, Poland.
D000735:Androstenedione / Q000031:analogs & derivatives* / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism; D007536:Isomerism; D009868:Oomycetes / Q000378:metabolism*; D010084:Oxidation-Reduction; D013739:Testosterone / Q000031:analogs & derivatives* / Q000378:metabolism
D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione