Generation of DNA damage by anti-neoplastic agents.
DNA has been one of the major targets of cancer chemotherapy. A variety of anti-neoplastic agents can cause different types of DNA lesions, including base alterations, single- or double-strand DNA breaks, DNA-DNA cross-links and DNA-protein cross-links. The exact processes by which these DNA lesions lead to cell death remain uncertain. However, pivotal roles of intracellular Ca2+ ion mobilization, activation of Ca(2+)-Mg(2+)-dependent endonuclease and induction of several oncogenes have been proposed. Understanding the mechanism of DNA damage and subsequent cell death will be important to improve the efficacy of cancer chemotherapy.
Kubota
M
M
Kyoto University Hospital, Department of Pediatrics, Japan.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D016923:Cell Death / Q000502:physiology; D004249:DNA Damage; D006801:Humans
D000970:Antineoplastic Agents