Synthesis and immunopharmacological analysis of selected butanic and butanodionic acid amides containing aziridine unit. II.
In the reaction of butanic and butanodionic acid chlorides with amines, amides 1-10 were produced. Addition of aziridine to a double bonds was performed in alkaline medium which resulted in aziridine derivatives of both acids. Pharmacological study revealed that the preparations examined possess immunotropic, strongly suppressive activity (PFC, E-RFC), partly IgG level; they leave the titer of circulating IgM unchanged. It seems that rather the basic system of acids than the substituents introduced to it are responsible for the effect of the compounds.
Kowalczyk-Bronisz
S H
SH
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Pomorski
J
J
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D001388:Aziridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D012397:Rosette Formation; D013329:Structure-Activity Relationship
D001388:Aziridines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents