[Expression of intermediate filament and oncogene proteins in squamous cell carcinomas of the oral cavity. Correlation of differentiation].
We investigated normal oral epithelium and 20 oral squamous cell carcinomas with antibodies against oncogene products (p21, EGF-R) and intermediate filaments (cytokeratins 4, -10/11, -13, -18, Vimentin). Antigen expressions in oral epithelium and squamous cell carcinomas were associated in different patterns with epithelial maturation. Dedifferentiation of the squamous cell carcinomas was accompanied by quantitative changes in the oncogene products and a more complex pattern of the cellular intermediate filament equipment.
Störkel
S
S
Institut für Pathologie der Universität Mainz.
Moll
R
R
Reichert
T
T
Gillenkirch
R
R
Spitz
S
S
Wagner
W
W
D000951:Antigens, Neoplasm / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000235:genetics; D002454:Cell Differentiation; D066246:ErbB Receptors / Q000032:analysis; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis*; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000235:genetics; D009363:Neoplasm Proteins / Q000032:analysis*; D016283:Proto-Oncogene Proteins p21(ras) / Q000032:analysis*
D000951:Antigens, Neoplasm; D007381:Intermediate Filament Proteins; D009363:Neoplasm Proteins; D066246:ErbB Receptors; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)
Expression von Intermediärfilament- und Onkogen-proteinen in Plattenepithelkarzinomen der Mundhöhle. Korrelation zur Differenzierung.