Effects of Croton zehntneri aqueous extracts on some cholinergic- and dopaminergic-related behaviours of laboratory rodents.
The effects of aqueous Croton zehntneri leaf and branch extracts, orally administered, on some dopaminergic- and cholinergic-related behaviours were studied in rats and mice. The leaf extract did not modify apomorphine-induced stereotypic behavior, haloperidol-induced catalepsy and active avoidance/escape responses. The branch extract reduced stereotypy but did not interfere with catalepsy and active avoidance behavior. Both extracts were capable of increasing the tremor induced by oxotremorine.
Giorgi
R
R
Department of Pathology, School of Veterinary Medicine, University of São Paulo, Brazil.
Batatinha
M J
MJ
Bernardi
M M
MM
DeSouza-Spinosa
H
H
Spinosa
F R
FR
Palermo-Neto
J
J
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002794:Choline / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000502:physiology; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains
D010936:Plant Extracts; D001058:Apomorphine; D002794:Choline; D004298:Dopamine