[New inhibitors of aromatase: synthesis and biological activity of pyridyl-substituted phenanthrenone derivatives].
The phenanthrenone derivatives 3-6 were synthesized and tested for their aromatase and desmolase inhibitory potency. Compounds 5 and 6 show a stronger inhibition of aromatase than aminoglutethimide not exceeding, however, the activity of the parent compounds 1 and 2. Compounds 4 and 5 do not inhibit desmolase.
Bayer
H
H
Fachrichtung Pharmazeutische Chemie, Universität des Saarlandes.
Hartmann
R W
RW
D047072:Aromatase Inhibitors; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000037:antagonists & inhibitors; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology
D047072:Aromatase Inhibitors; D010616:Phenanthrenes; D011725:Pyridines; D002786:Cholesterol Side-Chain Cleavage Enzyme
Neue Hemmstoffe der Aromatase: Synthese und biologische Aktivität pyridyl-substituierter Phenanthrenonderivate.