Clinical aspects on presynaptic noradrenaline metabolism.
In healthy subjects, similar absolute increments in plasma noradrenaline (NA) and dihydroxyphenylglycol (DOPEG) were observed in response to upright posture or isoprenaline infusion. Blockade of neuronal uptake by desipramine abolished these plasma DOPEG responses and reduced plasma DOPEG per se. In essential hypertensives we found higher than normal plasma DOPEG levels at any given plasma NA. Evidence is provided that both the desipramine-sensitive and -resistant pool of plasma DOPEG contribute to this hypertensive-normotensive difference.
Ludwig
J
J
Medical School, University of Würzburg, Federal Republic of Germany.
Halbrügge
T
T
Graefe
K H
KH
D002851:Chromatography, High Pressure Liquid; D003891:Desipramine / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000097:blood; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D011187:Posture; D012016:Reference Values; D016683:Supine Position; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
D008734:Methoxyhydroxyphenylglycol; D007545:Isoproterenol; D003891:Desipramine; C010117:3,4-dihydroxyphenylglycol; D009638:Norepinephrine