Antigenic variation of a major surface glycoprotein of Pneumocystis carinii.
The mannosylated surface glycoprotein (gp) of Pneumocystis carinii has one known conserved epitope that is recognized by the monoclonal antibody 85-1-5E12. The gp exhibits host species-specific antigenic variation, exhibits host species-specific collagenase sensitivity, and varies in size depending on the host of origin and the method of preparation. These data support the existence of host species-specific serotypes of P. carinii.
Gigliotti
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Department of Pediatrics, University of Rochester, NY 14642.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000940:Antigenic Variation; D000946:Antigens, Fungal / Q000276:immunology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000276:immunology*; D011010:Pneumocystis / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000946:Antigens, Fungal; D008562:Membrane Glycoproteins