[Regeneration of the sciatic nerve in the rat modified by neurotrophic factors].
In the present study an experimental rat model is presented enabling analysis of nerve regeneration in vivo through preformed tissue holes. The tissue space allows to bridge a gap about 10 mm. The neovascularization could follow the physiological course using the way through the epi- and perineurium in the chamber. The regeneration rate was investigated with and without application of a mixture of gangliosides showing a significant difference between both groups. Gangliosides stimulated the axonal outgrowth and the restoration of well-vascularized nerve fascicles. Further investigations should examine the effects of different neurotrophic substances in the tube.
Künnemann
J
J
Klinik für Chirurgie, Medizinischen Akademie Magdeburg.
Dietzmann
K
K
Heinrich
P
P
D000818:Animals; D005260:Female; D005732:Gangliosides / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D009132:Muscles / Q000294:innervation*; D009410:Nerve Degeneration / Q000187:drug effects / Q000502:physiology; D009416:Nerve Regeneration / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects* / Q000502:physiology
D005732:Gangliosides; D006493:Heparin
Regeneration im N. ischiadicus der Ratte unter dem Einfluss von neurotrophen Faktoren.