title: Electrospray ionization mass spectrometry of platinum anticancer agents.
abstract: Quantification and identification of platinum drugs and their metabolites in biological samples has always been difficult because these compounds are thermally unstable, non-volatile and insoluble. We have demonstrated that electrospray ionization mass spectrometry can be a valuable technique for direct mass spectral analysis of platinum anticancer agents and for obtaining structural information as a result of fragmentation. Full-scan spectra were obtained with approximately 10 pmol samples. These results show the potential of applying this technique in pharmacokinetic studies of platinum anticancer drugs.
authors.affiliation: Drug Development Section, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: G K
authors.initials: GK
authors.lastname: Poon
authors.forename: P
authors.initials: P
authors.lastname: Mistry
authors.forename: S
authors.initials: S
authors.lastname: Lewis
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis*; D002945:Cisplatin / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods; D009944:Organoplatinum Compounds / Q000032:analysis*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C023359:iproplatin; D002945:Cisplatin; C049777:ormaplatin