title: Loperamide but not morphine has anti-secretory effects in human colon, in vitro.
abstract: Isolated preparations of human colonic mucosa were set up in Ussing chambers. Noradrenaline reduced basal short-circuit current, morphine did not nor did loperamide except at the highest concentration tested. Electrically evoked increases in short-circuit current were unaffected by morphine but reduced by loperamide, by a naloxone-insensitive mechanism. Unidirectional fluxes of 22sodium and 36chloride were unaffected by morphine. It is concluded that loperamide but not morphine has an anti-secretory effect on human colonic mucosa.
authors.affiliation: Department of Pharmacology, Queen Mary and Westfield College, London, U.K.
authors.forename: D E
authors.initials: DE
authors.lastname: Burleigh
mesh_terms: D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D004558:Electric Stimulation; D006801:Humans; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D008139:Loperamide / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology
chemical_list: D008139:Loperamide; D009020:Morphine; D009638:Norepinephrine