[Protective action of some compounds against the toxicity of acetaldehyde, acrolein and formaldehyde in the rat].
The Authors report the protective activity of some compounds against the toxicity of acetaldehyde, acrolein and formaldehyde in the rat. The compounds were orally administered 30 min before and 5 hours after the toxicant aldehyde administration (acetaldehyde 2150 mg/kg os; acrolein 75 mg/kg os; formaldehyde 950 mg/kg os). L-cysteine and L-ascorbic acid showed a good protective activity against the three toxicant aldehydes. Cysteamine, BHT and propyl gallate showed activity against acetaldehyde and formaldehyde. Quercetin was active only against acetaldehyde whereas alpha-tocopherol was inactive.
Manzardo
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Centro Ricerche, Poli Industria Chimica, Rozzano (MI).
Coppi
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D000079:Acetaldehyde / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000171:Acrolein / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000447:Aldehydes / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000818:Animals; D005557:Formaldehyde / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000447:Aldehydes; D005557:Formaldehyde; D000171:Acrolein; D000079:Acetaldehyde
Azione protettiva di alcuni composti nei confronti della tossicità di acetaldeide, acroleina e formaldeide nel ratto.