The levels of pituitary-testicular axis hormones and SHBG in active acromegaly following bromocriptine treatment.
Pituitary and testicular hormone secretion and sex-hormone binding globulin (SHBG) level were investigated in 15 males with active acromegaly in normal and hyperprolactinemic state. Basal serum folitropin (FSH) and lutropin (LH) levels did not change before and after the administration of bromocriptine and remained in normal range compared with those in healthy men. Serum total testosterone concentration and SHBG were decreased particularly in hyperprolactinemic patients, but their levels were significantly increased to the normal limits following bromocriptine application. Although slight changes in serum concentration of free testosterone (fT) and circadian rhythm of fT in saliva was observed before and following bromocriptine treatment, the statistical differences were not significant. The results of the present study suggest that in acromegaly the alterations in peripheral metabolism of sexual steroids may exist.
Zwirska-Korczala
K
K
Department of Pathophysiology and Clinical Biochemistry, Silesian Academy of Medicine, Zabrze, Poland.
Ostrowska
Z
Z
Zych
F
F
Buntner
B
B
D000172:Acromegaly / Q000097:blood*; D000328:Adult; D001971:Bromocriptine / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000097:blood*; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000378:metabolism / Q000502:physiology; D012463:Saliva / Q000737:chemistry; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013737:Testis / Q000378:metabolism / Q000502:physiology; D013739:Testosterone / Q000032:analysis / Q000097:blood*
D012738:Sex Hormone-Binding Globulin; D001971:Bromocriptine; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone