The forced swimming test: effects of glucose administration on the response to food deprivation and adrenalectomy.
Rats food deprived for 24 h prior to a 15 min swimming test have no difficulty in acquiring the immobile response but showed significantly reduced levels of immobility (40%) on retest compared with controls (70%). This effect of food deprivation was reversed, by glucose (100 mg/kg), dexamethasone (6 micrograms/rat) and ketocyclazocine (25 micrograms/rat). Adrenalectomised animals also acquire but cannot retain the immobile response, however, adrenalectomised rats given 1000 mg/kg glucose within 2 h of the initial swimming test are immobile for 75-85% of the retest period. We interpret these findings as suggesting a complex interplay of endocrine and metabolic factors are necessary for retention of the behavioural response.
Jefferys
D
D
Baker Medical Research Institute, Prahran, Australia.
Funder
J W
JW
D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D003907:Dexamethasone / Q000494:pharmacology; D016314:Ethylketocyclazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D005508:Food Deprivation / Q000502:physiology*; D005947:Glucose / Q000494:pharmacology*; D008297:Male; D009068:Movement / Q000187:drug effects / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming; D013997:Time Factors
D016314:Ethylketocyclazocine; C012395:ketazocine; D003907:Dexamethasone; D005947:Glucose