title: Dysfibrinogenemia and thrombosis.
abstract: A thrombotic tendency (venous or arterial) has been reported in some cases of dysfibrinogenemia. We report here the mechanism by which these thrombosis may occur. It may be related either to a defective clot lysis due to a poor reactivity toward fibrinolytic enzymes or to a defective thrombin binding capacity of the abnormal clot. Acquired fibrin clot structure anomalies may also be responsible for a defective thrombolysis.
authors.affiliation: GEFFACS, Laboratoire Sainte Marie, Hôtel Dieu, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Soria
authors.forename: C
authors.initials: C
authors.lastname: Soria
authors.forename: J P
authors.initials: JP
authors.lastname: Collet
authors.forename: M
authors.initials: M
authors.lastname: Mirishahi
authors.forename: H
authors.initials: H
authors.lastname: Lu
authors.forename: J P
authors.initials: JP
authors.lastname: Caen
mesh_terms: D005337:Fibrin / Q000378:metabolism; D015241:Fibrinogens, Abnormal / Q000378:metabolism*; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D011485:Protein Binding; D013917:Thrombin / Q000378:metabolism; D013927:Thrombosis / Q000097:blood*
chemical_list: D015241:Fibrinogens, Abnormal; D005337:Fibrin; D013917:Thrombin