title: [Combined chemotherapy (mebendazole plus praziquantel) in patients with hydatidosis].
abstract: In February 1989 we began a combined treatment with mebendazole (3 g/day for 30 days) and praziquantel (1.8 g/day for 15 days) with variable rest periods, in a patients with hydatid disease who had been previously unsuccessful treated only with mebendazole. All the patients were monitored with serological techniques and radiography. Generally the treatment was without side-effects. According to radiography results, there was a reduction in the size of the cyst in 5 patients, in 2 there was no change and 1 patient, the cyst continued to increase in size. Results suggest that the combination of mebendazole more praziquantel could be a pharmacological alternative in the medical treatment of hydatid disease.
authors.affiliation: Servicios de Microbiología, Hospital 12 de Octubre, Madrid.
authors.forename: E
authors.initials: E
authors.lastname: Salto
authors.forename: E
authors.initials: E
authors.lastname: Juárez
authors.forename: M P
authors.initials: MP
authors.lastname: Roiz
authors.forename: J
authors.initials: J
authors.lastname: Abad
mesh_terms: D000368:Aged; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004443:Echinococcosis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D004444:Echinococcosis, Hepatic / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D011223:Praziquantel; D008463:Mebendazole
vernacular_title: Quimioterapia combinada (mebendazol más prazicuantel) en pacientes con hidatidosis.