title: Dissemination of Pneumocystis carinii in patients with AIDS.
abstract: Extrapulmonary Pneumocystis carinii infections in AIDS are still rare although the number of cases is increasing. We present 2 cases of extrapulmonary pneumocystosis detected at our institution during an 8-month period. The first was a patient treated for P. carinii pneumonia (PCP) disseminated to liver, spleen and kidneys. The second patient had widely dissemination of P. carinii diagnosed at autopsy. Both patients had received aerosolised pentamidine (AP) for PCP prophylaxis. Totally we have treated patients with AP prophylaxis for 122 patient years and found a frequency of extrapulmonary spread of 1.6% compared to none in the 116 patient years on sulfamethoxazole-trimethoprim.
authors.affiliation: Department of Infectious Disease, Hvidovre Hospital, University of Copenhagen, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Witt
authors.forename: T N
authors.initials: TN
authors.lastname: Nielsen
authors.forename: J
authors.initials: J
authors.lastname: Junge
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000336:Aerosols; D006801:Humans; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D010419:Pentamidine / Q000008:administration & dosage / Q000627:therapeutic use*; D011010:Pneumocystis / Q000254:growth & development; D016720:Pneumocystis Infections / Q000150:complications* / Q000517:prevention & control; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000336:Aerosols; D010419:Pentamidine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination