Mitogen induced proliferation and cytokine production by lymphocytes from leprosy patients.
In this paper we have assessed the mitogen responses of leprosy patients and healthy donors in terms of proliferation and cytokine production (Interleukin 2 and Interferon gamma). The patients investigated included untreated and multidrug therapy non-responsive LL patients and MDT responsive LL and TT patients. The mitogen responses of untreated and multidrug therapy non responsive LL patients were not significantly different from those of the healthy donors. It was interesting to note that TT and multidrug therapy responsive LL patients showed higher responses to mitogens than healthy donors as assessed by all three parameters. The results suggest a correlation of increased mitogenic responses with improvement in clinical status in leprosy.
Shinde
S R
SR
Immunology Division, Tata Memorial Centre, Bombay, India.
Chiplunkar
S V
SV
Butlin
R
R
Samson
P D
PD
Deo
M G
MG
Gangal
S G
SG
D002455:Cell Division; D003208:Concanavalin A; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D007917:Leprostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015440:Leprosy, Lepromatous / Q000188:drug therapy / Q000276:immunology*; D015441:Leprosy, Tuberculoid / Q000188:drug therapy / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D010835:Phytohemagglutinins
D007376:Interleukin-2; D007917:Leprostatic Agents; D010835:Phytohemagglutinins; D003208:Concanavalin A; D007371:Interferon-gamma