title: Effects of dorsal raphe stimulation on cerebral glucose utilization in the anaesthetized rat.
abstract: The aim of this study was to determine the effects of electrical stimulation of the dorsal raphe nucleus on local cerebral glucose utilization (LCGU) in the alpha-chloralose anaesthetized rat. Activation of the dorsal raphe nucleus effected significant increases in LCGU, ranging from 13 to 52% in 8 brain structures out of 33 investigated. Increases were restricted to extrapyramidal and limbic non-specific areas, and no modifications were observed in cortical areas. The comparison with our previous results, showing that a similar raphe activation induced a global decrease in local cerebral blood flow, suggests that the ascending serotonergic system may be of importance in the regulation of the cerebral circulation.
authors.affiliation: Laboratoire de Recherches Cérébrovasculaires, CNRS, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Bonvento
authors.forename: P
authors.initials: P
authors.lastname: Lacombe
authors.forename: E T
authors.initials: ET
authors.lastname: MacKenzie
authors.forename: J
authors.initials: J
authors.lastname: Seylaz
mesh_terms: D000758:Anesthesia; D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003847:Deoxyglucose / Q000494:pharmacology; D004558:Electric Stimulation; D005947:Glucose / Q000378:metabolism*; D008297:Male; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003847:Deoxyglucose; D005947:Glucose