The neutrophil chemiluminescence response to Pneumocystis carinii is stimulated by GM-CSF and gamma interferon.
The interaction of Pneumocystis carinii purified from rat lung with human polymorphonuclear leukocytes (PMN) was studied using amplified chemiluminescence. Pre-incubation of PMN with granulocyte-macrophage stimulating factor or gamma interferon resulted in phagocyte stimulation.
Taylor
M B
MB
Department of Medical Microbiology, St. Mary's Hospital Medical School, London, U.K.
Easmon
C S
CS
D000818:Animals; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D008163:Luminescent Measurements; D008168:Lung / Q000166:cytology; D009504:Neutrophils / Q000276:immunology*; D011010:Pneumocystis / Q000276:immunology*; D016720:Pneumocystis Infections / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D016897:Respiratory Burst
D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor