title: Regional changes in spinal cord glucose metabolism in a rat model of painful neuropathy.
abstract: Spinal cord patterns of metabolic activity in a model of neuropathic pain were assessed in unanesthetized rats by the [14C]-2-deoxyglucose (2-DG) technique. Rats used in this procedure had demonstrable thermal hyperalgesia ipsilateral to sciatic nerve ligation and ipsilateral hindpaws that were lifted in a guarded position. The latter indicated possible spontaneous pain. Sciatic nerve ligation produced significant increases in glucose utilization in the dorsal and ventral horns of both sides, with greater activity present on the ipsilateral as compared to the contralateral side. Peak activity was in laminae V-VI, a region involved in nociceptive processing. Thus, a chronic increase in neuronal activity in these regions may reflect spontaneous neuropathic pain.
authors.affiliation: Department of Anesthesiology, Medical College of Virginia, Richmond 23298.
authors.forename: D D
authors.initials: DD
authors.lastname: Price
authors.forename: J R
authors.initials: JR
authors.lastname: Mao
authors.forename: R C
authors.initials: RC
authors.lastname: Coghill
authors.forename: D
authors.initials: D
authors.lastname: d'Avella
authors.forename: R
authors.initials: R
authors.lastname: Cicciarello
authors.forename: M G
authors.initials: MG
authors.lastname: Fiori
authors.forename: D J
authors.initials: DJ
authors.lastname: Mayer
authors.forename: R L
authors.initials: RL
authors.lastname: Hayes
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003847:Deoxyglucose; D005947:Glucose / Q000378:metabolism*; D007091:Image Processing, Computer-Assisted; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D009422:Nervous System Diseases / Q000378:metabolism*; D010146:Pain / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000502:physiology; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: D003847:Deoxyglucose; D005947:Glucose