[Central side effects of long-term treatment of Parkinson disease with levodopa preparations].
198 patients with Parkinson's disease on long-term treatment with L-dopa were evaluated for the presence of dyskinesias and psychiatric side-effects of the treatment. Dyskinesias were present in 53% of the patients. In a majority of them they appeared already during the first 2 years of the treatment. Younger patients seemed more susceptible to develop dyskinesias. Hallucinations, confusion, or delusions were observed in 22.2% of the patients. Older patients seemed more susceptible to develop these side-effects of the treatment. It seems that parkinsonian patients with later and earlier onset of the disease have different type of neuronal lesion responsible for the central side-effects of L-dopa.
Friedman
A
A
Kliniki Neurologicznej AM, Warszawie.
Sienkiewicz
J
J
D000328:Adult; D000368:Aged; D003072:Cognition Disorders / Q000139:chemically induced*; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000523:psychology; D019966:Substance-Related Disorders / Q000209:etiology*; D013997:Time Factors
D007980:Levodopa
Ośrodkowe objawy uboczne długotrwałego leczenia preparatami lewodopy w chorobie parkinsona.