DNA-damaging, mutagenic, clastogenic and cell-cell communication inhibitory properties of gamma-oryzanol.
As a part of short-term safety assessment of gamma-Oryzanol, the genotoxic or the carcinogenic initiation activity was studied in three genetic toxicity tests and the promotion activity was studied in a cell-cell communication inhibitory test. gamma-Oryzanol showed the negative response in the bacterial DNA repair test (Rec-assay), the bacterial reverse mutation tests (Ames test) and the rat bone marrow chromosome aberration test. Also, gamma-Oryzanol showed the negative response in the metabolic cooperation inhibition test using Chinese hamster V79 cells.
Tsushimoto
G
G
Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co. Ltd., Japan.
Shibahara
T
T
Awogi
T
T
Kaneko
E
E
Sutou
S
S
Yamamoto
K
K
Shirakawa
H
H
D000818:Animals; D002450:Cell Communication / Q000187:drug effects*; D004247:DNA / Q000187:drug effects*; D004249:DNA Damage; D000960:Hypolipidemic Agents / Q000633:toxicity*; D008297:Male; D009153:Mutagens; D010666:Phenylpropionates / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D000960:Hypolipidemic Agents; D009153:Mutagens; D010666:Phenylpropionates; D004247:DNA; C013172:gamma-oryzanol