title: Maternal plasma concentrations of insulin-like growth factor-I (IGF-I) and human placental lactogen (hPL) in twin pregnancies.
abstract: Maternal plasma IGF-I and hPL concentrations were examined in 10 singleton pregnancies and in 11 twin gestations near term. hPL concentrations were higher in the twin pregnancies (14.4 +/- 2.4 micrograms/l vs 6.9 +/- 0.9 micrograms/l, P less than 0.02). In contrast, plasma IGF-I concentrations were similar in the singleton and twin pregnancies (533 +/- 45 micrograms/l vs 572 +/- 60 micrograms/l, respectively). IGF-I concentrations failed to correlate with hPL concentrations in either group separately or when all subjects were considered together. These data do not support the hypothesis that maternal IGF-I secretion is an hPL-dependent process.
authors.affiliation: Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois.
authors.forename: R R
authors.initials: RR
authors.lastname: Kazer
authors.forename: E R
authors.initials: ER
authors.lastname: Cheng
authors.forename: T G
authors.initials: TG
authors.lastname: Unterman
authors.forename: R P
authors.initials: RP
authors.lastname: Glick
mesh_terms: D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D010928:Placental Lactogen / Q000097:blood*; D011247:Pregnancy; D011272:Pregnancy, Multiple / Q000097:blood*; D014427:Twins
chemical_list: D007334:Insulin-Like Growth Factor I; D010928:Placental Lactogen