Inoculated mouse model of Pneumocystis carinii pneumonia.
A transtracheally inoculated mouse model of Pneumocystis carinii has been developed using BALB/c mice, a widely available strain free of latent P. carinii infection. The mean infectivity score of untreated inoculated mice was 4.1 compared to the mean infectivity score of 0.1 for trimethoprim/sulfamethoxazole (50/250 mg/kg) treated inoculated mice, approximately a four-log difference. An inoculated mouse model of P. carinii infection provides both a source of organisms from a different host and an animal model for study of drugs for therapy and prophylaxis which is less costly than rats and which requires less drug than required for rats.
Bartlett
M S
MS
Department of Pathology, Indiana University School of Medicine, Indianapolis 46202-5250.
Queener
S F
SF
Durkin
M M
MM
Shaw
M M
MM
Smith
J W
JW
D000818:Animals; D004195:Disease Models, Animal; D007165:Immunosuppression Therapy; D051379:Mice; D008815:Mice, Inbred Strains; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000382:microbiology* / Q000635:transmission