Comparative evaluation of two combined measles-mumps-rubella vaccines based on AIK and Edmonston- Zagreb strains of measles virus.
In a previous paper, we have noticed the effectiveness of two further attenuated measles vaccines, i.e. AIK-HDC and Edmonston- Zagreb- HDC. In the present study the same strains are comparatively used for immunization of a limited number of children under 9 months of age. A seroconversion of 100% was observed. Following reimmunization, a significant increase of circulating antibodies for both strains was recorded. Two combined measles-mumps-rubella (MMR) vaccines were also produced by using the same measles strains. The seroconversion following utilisation of MMR prophylactics in susceptible children was 98.8 and 97.3 for AIK and Edmonston- Zagreb strains respectively.
Mirchamsy
H
H
Razi State Serum & Vaccine Institute, Tehran, Islamic Republic of Iran.
Nilforoushan
M A
MA
Shafyi
A
A
Razavi
J
J
Ashtiani
M P
MP
Youssofi
I
I
Sassani
A
A
Fateh
G
G
Nassiri
S
S
D000914:Antibodies, Viral / Q000096:biosynthesis; D002675:Child, Preschool; D004338:Drug Combinations; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007114:Immunization; D007223:Infant; D008297:Male; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000145:classification* / Q000276:immunology; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology; D012411:Rubella Vaccine / Q000276:immunology*; D012412:Rubella virus / Q000276:immunology; D014613:Vaccines, Attenuated / Q000276:immunology
D000914:Antibodies, Viral; D004338:Drug Combinations; D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated