title: Antisense antivirals.
abstract: The antiviral use of antisense oligonucleotides is described with particular reference to our own work on the inhibition of HIV-1. Subjects include the design, metabolism, and modification of these agents and the possible future use of ribozymes.
authors.affiliation: Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts.
authors.forename: J
authors.initials: J
authors.lastname: Goodchild
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D015195:Drug Design; D006678:HIV / Q000187:drug effects; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D016337:RNA, Catalytic / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D016376:Oligonucleotides, Antisense; D016337:RNA, Catalytic