Topical administration of leukotriene antagonists in immunogenic keratitis.
Antagonists of leukotriene D4 (LTD4), 3-[7-(2-n-propyl-3-hydroxy-4-acetyl- phenoxy)-propoxy-2-methyl-3,4-dihydro-4-8-n-propyl-2H-1-benzopyran- 2-yl]-propionic acid (SC-39070) and 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxy- propoxy]-4-methyl- 2-oxo-2H-1-benzopyran-3-acetic acid (FPL-60319) were locally administered to eyes of rabbits with immunogenic keratitis. The period of circular leukocyte infiltration (Wessely's ring) in the cornea was markedly decreased. Edema and neovascularization of the cornea were not influenced.
van Delft
J L
JL
Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
van Haeringen
N J
NJ
Barthen
E R
ER
van Best
J A
JA
Blackham
A
A
D000287:Administration, Topical; D000818:Animals; D002634:Chemotaxis, Leukocyte; D002867:Chromones / Q000008:administration & dosage*; D015715:Corneal Edema / Q000473:pathology; D016510:Corneal Neovascularization / Q000473:pathology; D007634:Keratitis / Q000188:drug therapy / Q000473:pathology*; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D011817:Rabbits; D013189:SRS-A / Q000037:antagonists & inhibitors*
D002867:Chromones; D013189:SRS-A; C034338:FPL 57231; C052027:SC 39070