Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes.
Juvenile diabetics have severe loss of beta cell function and require replacement therapy with insulin. Insulin antigenicity can produce anti-insulin antibodies resulting in allergic reactions and insulin resistance. The role of insulin-anti-insulin antibody complexes in the development and progress of chronic diabetic complications like microangiopathy is not very clear. In the present study, there was statistically a significant trend of higher insulin antibody binding levels in IDDM patients who developed retinopathy. Though there was a trend of higher insulin antibody in IDDM patients with retinopathy, there was no association between insulin antibody and HLA antigen which some authors have reported.
Sharma
K
K
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, Department of Medicine, All India Institute of Medical Sciences, New Delhi.
Khosla
P K
PK
Tiwari
H K
HK
Sharma
R K
RK
Bajaj
J S
JS
D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood* / Q000209:etiology; D015235:HLA-B Antigens / Q000097:blood; D006650:Histocompatibility Testing; D006801:Humans; D007330:Insulin Antibodies / Q000097:blood*; D011863:Radioimmunoassay
D015235:HLA-B Antigens; D007330:Insulin Antibodies