[Activity of natural killer cells of peripheral blood in patients with rheumatoid arthritis and their clinical significance].
The authors studied the activity of peripheral blood natural killer cells in 25 patients with rheumatoid arthritis by 51 Cr release assays with K-568 target cells. Data on the comparative clinico-immunological analysis by the cytotoxicity index are submitted. There is a relation between the nature of rheumatoid arthritis course and the presence of systemic manifestations such as nodules, polyneuropathy, proteinuria, carditis, levels of the rheumatoid factor, anti-DNA, CRP, cryoglobulinemia and changed activity of peripheral blood natural killer cells. Patients with rheumatoid arthritis having a combination of marked changes of humoral immunity with changed cytotoxicity of the peripheral blood natural killer cells activity can be referred to the group of risk.
Satybaldyev
A M
AM
Riazantseva
T A
TA
Speranskiĭ
A I
AI
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000032:analysis / Q000276:immunology; D012307:Risk Factors; D012720:Severity of Illness Index
D000974:Antibodies, Antinuclear; D012217:Rheumatoid Factor
Aktivnost' natural'nykh killerov perifericheskoĭ krovi u bol'nykh revmatoidnym artritom i ikh klinicheskoe znachenie.