title: Dual-isotope imaging of neutron-activated erbium-171 and samarium-153 and the in vivo evaluation of a dual-labeled bilayer tablet by gamma scintigraphy.
abstract: The feasibility of dual-label scintigraphic studies which use the neutron-activated isotopes erbium-171 and samarium-153 is described. Experimental details are provided to correct and minimize the compton scatter contribution of 171Er into the lower-energy 153Sm window. The results from this study demonstrate that this dual-label procedure is sensitive enough to monitor simultaneously the behavior of two discrete regions of the same unit dose in the gastrointestinal tract of man.
authors.affiliation: Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536-0082.
authors.forename: G A
authors.initials: GA
authors.lastname: Digenis
authors.forename: E P
authors.initials: EP
authors.lastname: Sandefer
authors.forename: R M
authors.initials: RM
authors.lastname: Beihn
authors.forename: A F
authors.initials: AF
authors.lastname: Parr
mesh_terms: D004064:Digestive System / Q000000981:diagnostic imaging; D004871:Erbium; D005772:Gastrointestinal Transit; D006801:Humans; D007553:Isotope Labeling; D009501:Neutron Activation Analysis; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012493:Samarium; D013607:Tablets
chemical_list: D011868:Radioisotopes; D013607:Tablets; D012493:Samarium; D004871:Erbium