Fetal outcome following intrauterine amantadine exposure.
Amantadine hydrochloride is a well-known antiviral agent that has been used for the prevention of influenza A2, the treatment of Parkinson disease, and, more recently, multiple sclerosis. However, very few data exist about its use in pregnant women. We report a 34-year-old woman who had used amantadine to prevent relapse of her multiple sclerosis throughout two of her pregnancies who subsequently delivered two normal infants. We review the available animal data and two other human pregnancy exposure reports.
Levy
M
M
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Pastuszak
A
A
Koren
G
G
D000328:Adult; D000547:Amantadine / Q000009:adverse effects*; D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008431:Maternal-Fetal Exchange; D009103:Multiple Sclerosis / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome
D000547:Amantadine