Clinical, biological, and histological follow-up during intestinal adaptation after small-bowel resection in the dog.
Massive resections of the intestine including the ileocecal valve are associated with a high mortality. This model of short bowel in the dog consists of an extensive small-bowel resection (remaining jejunum 25 cm) associated with colectomy. Small-bowel adaptation is evidenced by increases of crypt depth (p = 0.02) and villus height (p = 0.001) in animals fed per os. Plasma glutamine levels decrease after surgery, while there is a significant decrease of plasma alanine levels (p less than 0.001). This model should allow to pursue investigations on the importance of glutamine as an essential fuel for intestinal mucosa regeneration.
Gouttebel
M C
MC
Laboratory of Nutrition and Experimental Oncology, Cancer Institute, Montpellier, France.
Astre
C
C
Girardot
P M
PM
Saint-Aubert
B
B
Joyeux
H
H
D000222:Adaptation, Physiological; D000596:Amino Acids / Q000097:blood; D000818:Animals; D004285:Dogs; D005260:Female; D005973:Glutamine / Q000378:metabolism; D007421:Intestine, Small / Q000473:pathology / Q000502:physiology / Q000601:surgery*; D008297:Male
D000596:Amino Acids; D005973:Glutamine