title: Enamel solubility profile of irradiated rat molars.
abstract: The solubility of molar enamel was tested in irradiated rats treated with fluoride (F-). Seventy-five 21-day-old rats were divided into five groups. The first group received F- in the drinking water (25 p.p.m.), one group was irradiated only (one single dose of 15 Gy to the head); one group was started on F- 3 weeks before irradiation, in one group the commencement of the F- regimen coincided with irradiation. The last group served as a control. The animals were sacrificed at 80 days old. Enamel solubility of the molar teeth, measured as Ca++ release in an etchant, was determined separately in three consecutive immersions. Fluoridation and irradiation reduced enamel solubility, albeit in a dissimilar depth-related amplitude. Whether administered prior to or following irradiation, F- reduced enamel solubility in a pattern resembling that of the non-irradiated F- treated group.
authors.affiliation: Department of Oral Medicine, Oral Diagnosis and Oral Radiology, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Markitziu
mesh_terms: D000818:Animals; D002118:Calcium / Q000032:analysis; D003037:Cobalt Radioisotopes; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects / Q000528:radiation effects*; D003747:Dental Enamel Solubility / Q000187:drug effects / Q000528:radiation effects*; D005459:Fluorides / Q000032:analysis / Q000494:pharmacology*; D008297:Male; D008963:Molar; D011829:Radiation Dosage; D051381:Rats
chemical_list: D003037:Cobalt Radioisotopes; D005459:Fluorides; D002118:Calcium