title: [Tumor markers in the early diagnosis of recurrence in gynecologic neoplasms: combined determination of CA-125, CA 15-3, CA 72.4, SCC, 90 K].
abstract: In 156 patients with gynecologic neoplasia the sieric levels of tumor markers (CA 125, CA 15-3, CA 72.4, SCC and 90 K) before the primary treatment and during the follow-up have been evaluated. In the patients with ovarian cancer elevated levels of CA 125 (80%), CA 72.4 (62%), 90 K (49%) and CA 15-3 (16.6) were found. The integrated evaluation of CA 125 and 90 K sieric levels was positive in the 86% of cases. The evaluation of CA 125 in combination with 90 K seems to facilitate the earlier detection of ovarian cancer recurrences. Elevated levels of SCC (89%) were found in the patients with cervical cancer. In the patients with endometrial or vulvar cancer the evaluation of these tumor markers was not significant.
authors.affiliation: Istituto di Clinica Ostetrica e Ginecologica, Università degli Studi di Ancona.
authors.forename: G C
authors.initials: GC
authors.lastname: Garzetti
authors.forename: R M
authors.initials: RM
authors.lastname: Di Lauro
authors.forename: A
authors.initials: A
authors.lastname: Ciavattini
authors.forename: M R
authors.initials: MR
authors.lastname: Pallotta
authors.forename: F
authors.initials: F
authors.lastname: Marchegiani
authors.forename: H
authors.initials: H
authors.lastname: Valensise
authors.forename: A L
authors.initials: AL
authors.lastname: Tranquilli
authors.forename: D
authors.initials: D
authors.lastname: Arduini
authors.forename: C
authors.initials: C
authors.lastname: Romanini
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000175:diagnosis*; D015843:Serpins; D013997:Time Factors
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D015843:Serpins; C051072:squamous cell carcinoma-related antigen
vernacular_title: Markers tumorali nella diagnosi precoce di ripresa di malattia nelle neoplasie ginecologiche: valutazione combinata del CA-125, CA 15-3, CA 72.4, SCC, 90 K.