title: Vanidil: a newly synthesized antiangina nonvolatile organic solid nitrate.
abstract: Newly synthesized Vanidil (4-o-(1,2-dinitroglyceryl)-6-nitrovanillic acid) is a nonvolatile organic solid nitrate, mp: 85 degrees C. In in vitro tests, Vanidil can inhibit 3,4-diaminopyridine (2 x 10(-2) M) induced pig coronary rhythmic vasocontraction, a prelude to coronary vasospasm, and nonrhythmic tonic vasocontraction. Vanidil is suggested as a potential antiangina agent.
authors.affiliation: Department of Pharmacology, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: I J
authors.initials: IJ
authors.lastname: Chen
authors.forename: Z I
authors.initials: ZI
authors.lastname: Liu
authors.forename: J L
authors.initials: JL
authors.lastname: Yeh
authors.forename: B N
authors.initials: BN
authors.lastname: Wu
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy*; D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D005996:Nitroglycerin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; C072709:Vanidil; D005996:Nitroglycerin