Effect of fencamfamine on avoidance performances of rats.
The effects of fencamfamine (1.0 and 5.0 mg/kg, ip, single dose) on an inhibitory task were studied in rats (N = 15 per group). Post-training treatment with fencamfamine (1.0 mg/kg) significantly increased avoidance latency from 23 +/- 3 to 146 +/- 28 and 170 +/- 33 s for training day 1 and day 7, respectively, indicating an enhancement of retention. However, retention was significantly reduced with a high dose of fencamfamine (5.0 mg/kg). These results demonstrate that fencamfamine caused a reproducible dose-related increase and reduction in avoidance latency.
DeLucia
R
R
Departamento de Farmacologia, Universidade de São Paulo, Brasil.
Aizenstein
M L
ML
Planeta
C S
CS
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects*; D008297:Male; D009636:Norbornanes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012153:Retention, Psychology / Q000187:drug effects*
D002395:Catecholamines; D009636:Norbornanes; C020900:fencamfamine