title: Histologic evaluation of crushed cartilage grafts in the growing nasal septum of young rabbits.
abstract: The evolution of crushed cartilage grafts in a growing nasal septum of young rabbits was histologically investigated. Crushing leads to necrosis of the greater part of the graft. The characteristic distribution of surviving cells in isolated areas at the surface of the graft reflects different mechanical properties of the centrally and peripherally located cartilage. The necrotic parts are eliminated and replaced by new cartilage formed by surviving chondrocytes or perichondrium. The result is a complex structure composed of two types of cartilage and of fibrous tissue without any distinct organization, but nevertheless capable of growth. However, it lacks strength to transform growth into adequate lengthening of the septum. Subsequently, this will lead to the development of multiple deviations. It is concluded that crushed cartilage is no suitable implant for the reconstruction of parts of the septum which are essential in supporting the outgrowth of the nose.
authors.affiliation: Department of Otorhinolaryngology, Erasmus University Rotterdam, The Netherlands.
authors.forename: H L
authors.initials: HL
authors.lastname: Verwoerd-Verhoef
authors.forename: C A
authors.initials: CA
authors.lastname: Meeuwis
authors.forename: R O
authors.initials: RO
authors.lastname: van der Heul
authors.forename: C D
authors.initials: CD
authors.lastname: Verwoerd
mesh_terms: D000818:Animals; D002356:Cartilage / Q000293:injuries / Q000473:pathology / Q000637:transplantation*; D005260:Female; D009300:Nasal Septum / Q000254:growth & development / Q000473:pathology* / Q000601:surgery; D009336:Necrosis; D011817:Rabbits; D014945:Wound Healing