The therapeutic and biological effects of total lymph node irradiation and autologous bone marrow infusion on malignant lymphoma patients.
Forty patients with malignant lymphoma were treated by 60Co total lymphoid irradiation (TLI): 21 cases received 6 Gy and 19 received 8 Gy. Ten also received autologous bone marrow infusion (ABMI). Acute radiation damage with digestive tract reaction and hemopoietic and immunological depression was observed. Bone marrow was depressed. WBC and platelets decreased rapidly. Lymphocytes showed quantitative and qualitative changes even at the early stage. All these symptoms subsided within 40 days. TLI accompanied by irradiation of the tumor site could result in effective control. The 1-, 3-, and 5-year survival rates of malignant lymphoma patients were 30/40 (75%), 14/24 (58%) and 4/12 (33%), respectively, while in those with Hodgkin's disease alone, the 1- and 3-year survival rates were 10/13 (76%) and 5/7 (71.4%), respectively. ABMI hastened hemopoietic reconstitution, which recovered relatively quickly after TLI.
Yu
S
S
Department of Oncology, North Taiping Road Hospital, Beijing.
Chen
Z
Z
Chen
Y
Y
Jiang
C
C
Guo
T
T
Jiang
B
B
Gao
P
P
Kong
X
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007958:Leukocyte Count; D015182:Lymphatic Irradiation; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011867:Radioisotope Teletherapy; D014182:Transplantation, Autologous; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes; D006854:Hydrocortisone