Observations on the carcinogenicity of asbestos fibers.
This paper summarizes animal experiments and in vitro data carried out to study the oncogenic effects of asbestos fibers on mesothelial cells. An interpretation of the results is made in light of current statements on the carcinogenicity of asbestos fibers. Experimental results appear to show that the carcinogenicity of mineral fibers is a complex, multiparametric phenomenon. Chromosomal mutations and possibly oxygen derivatives are involved in the genesis of the fiber-induced neoplastic process and may be the result of the intrinsic fiber properties, size, and physicochemistry. The role of fiber solubility is discussed; it is suggested that additional experiments are necessary for a better understanding of the importance of solubility in the concept of biopersistence.
Jaurand
M C
MC
Laboratory of Cellular and Molecular Environmental Toxicology, INSERM U 139, CHU Henri Mondor, Créteil, France.
D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D002273:Carcinogens; D008175:Lung Neoplasms / Q000209:etiology* / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008654:Mesothelioma / Q000209:etiology* / Q000378:metabolism; D010316:Particle Size
D002273:Carcinogens; D001194:Asbestos; D008274:Magnesium