The application of a multistage model that incorporates DNA damage and repair to the analysis of initiation/promotion experiments.
In a previous article, a multistage model of carcinogenesis was introduced that takes into account the role of DNA damage, DNA repair, and cell replication on the incidence of malignancies. For this model the number of detectable clones of initiated cells is derived and model parameters are estimated using data arising from a two-stage skin-painting experiment in mice. The data from this experiment are interpretable in terms of the cellular events involved in initiation and promotion.
Kopp-Schneider
A
A
Abteilung Biostatistik, Institut für Epidemiologie und Biometrie, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
Portier
C J
CJ
Rippmann
F
F
D000818:Animals; D002273:Carcinogens; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000139:chemically induced / Q000235:genetics*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000235:genetics / Q000473:pathology
D002273:Carcinogens