title: Seizure outcome in children with hemispheric tumors and associated intractable epilepsy: the role of tumor removal combined with seizure foci resection.
abstract: Children harboring hemispheric tumors associated with intractable epilepsy were retrospectively reviewed to assess seizure outcome following tumor resection and electrocorticography-guided seizure foci removal. Thirteen (93%) of our patients have remained seizure-free, off anticonvulsants or on tapering doses, following surgery with a mean follow-up of 33 months. Fifteen of 16 (93%) seizure foci examined histologically were void of tumor infiltration. A review of the literature is provided regarding the controversy of tumor removal versus additional seizure foci removal at the time of tumor removal in providing optimal seizure control.
authors.affiliation: University of Washington Medical Center, Seattle.
authors.forename: M S
authors.initials: MS
authors.lastname: Berger
authors.forename: S
authors.initials: S
authors.lastname: Ghatan
authors.forename: J R
authors.initials: JR
authors.lastname: Geyer
authors.forename: G E
authors.initials: GE
authors.lastname: Keles
authors.forename: G A
authors.initials: GA
authors.lastname: Ojemann
mesh_terms: D000293:Adolescent; D001931:Brain Mapping / Q000295:instrumentation; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004292:Dominance, Cerebral / Q000502:physiology; D004566:Electrodes; D004569:Electroencephalography / Q000295:instrumentation; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative / Q000295:instrumentation; D014057:Tomography, X-Ray Computed