Air pollution and asthma: clinical studies with sulfuric acid aerosols.
Until recently, acid deposition has been widely considered a serious ecological problem but not a threat to human health. The controlled clinical study is an important approach in linking acidic aerosol inhalation with respiratory effects. Asthmatic patients represent a subpopulation most responsive to sulfuric acid aerosols. In a series of studies with asthmatic volunteers, several factors have been identified that may modulate the intensity of the bronchoconstrictor response to inhaled acidic aerosols. We found (1) enhancement of the bronchoconstrictor response during exercise, (2) the more acidic aerosols provoke the greatest changes in lung function, and (3) mitigation of airway responses during sulfuric acid aerosol inhalation caused by high respiratory ammonia concentrations. Additional factors influencing responsiveness await identification.
Utell
M J
MJ
University of Rochester School of Medicine and Dentistry, NY 14642.
Frampton
M W
MW
Morrow
P E
PE
D000328:Adult; D000336:Aerosols; D000368:Aged; D000397:Air Pollution / Q000009:adverse effects; D001249:Asthma / Q000503:physiopathology*; D016084:Bronchoconstriction / Q000187:drug effects; D015444:Exercise; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology; D008875:Middle Aged; D015656:Respiratory Mechanics / Q000187:drug effects*; D013464:Sulfuric Acids / Q000494:pharmacology*
D000336:Aerosols; D013464:Sulfuric Acids