[Rat liver mitochondrial DNA treated with 1,2-dimethylhydrazine].
Primary structure of 5'-end 16S RNA gene of mitochondrial DNA (mDNA) isolated from rat liver tissue within 20 hrs after treatment with 1,2-dimethyl hydrazine, was analyzed. The preparations studied did not contain mutations induced by the drug. The region of mDNA analyzed appears not to be a preferential target for mutagenic effect of 1,2-dimethyl hydrazine unber these experimental conditions.
Fedorov
S N
SN
Balanski
R M
RM
Novikov
L B
LB
Levanova
G I
GI
Likhachev
A Ia
AIa
Anisimov
V N
VN
Khanson
K P
KP
D019813:1,2-Dimethylhydrazine; D000818:Animals; D001483:Base Sequence; D002273:Carcinogens / Q000633:toxicity*; D004272:DNA, Mitochondrial / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D004127:Dimethylhydrazines / Q000633:toxicity*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D008969:Molecular Sequence Data; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D051381:Rats
D002273:Carcinogens; D004272:DNA, Mitochondrial; D004127:Dimethylhydrazines; D012336:RNA, Ribosomal, 16S; D019813:1,2-Dimethylhydrazine
Issledovanie mitokhondrial'noĭ DNK pecheni krys, obrabotannykh 1,2-dimetilgidrazinom.