Immunopathology of hepatitis B mediated membranous glomerulonephritis.
The study was undertaken to establish the clinical and immunological aspects of HBV-mediated membranous glomerulonephritis in children. Out of 54 children with membranous GN treated in the Children's Memorial Hospital 51 children (94.4%) had the disease related to HBV infection. The inhibitory effect of immune complexes: HBsAg-IgG and HBeAg-IgG, isolated from sera of these children on lymphocyte proliferation of blood donors was observed. This may partly explain the status of immune tolerance towards HBV in the infected children.
Madaliński
K
K
Department of Clinical Immunology, Children's Memorial Hospital, Warsaw, Poland.
Jung
H
H
Stachowski
J
J
Kossowski
J
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006509:Hepatitis B / Q000150:complications*; D006510:Hepatitis B Antibodies / Q000097:blood; D006511:Hepatitis B Antigens; D006801:Humans; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male
D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D007376:Interleukin-2