Calcitonin gene-related peptide in rat arterial and venous vessels: sensitivity to capsaicin, bradykinin and FMLP.
Sensitivity of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) to capsaicin was investigated in different arterial and venous tissues (mesenteric, renal and femoral artery and vein and carotid artery and jugular vein) of the rat. In vivo capsaicin pre-treatment depleted or reduced tissue CGRP-LI in all the vessels examined with the exception of the carotid artery. Likewise, in vitro exposure to capsaicin evoked release of CGRP-LI from all vessels, excluding the carotid artery. Remarkable amount of CGRP-LI sensitive to capsaicin was present in both mesenteric artery and vein as compared to the other vascular tissues. Endogenous (bradykinin) or exogenous (N-formyl-methionyl-leucyl-phenylalanine) proinflammatory agents, were found to release CGRP-LI from mesenteric veins.
Del Bianco
E
E
Institute of Internal Medicine IV, University of Florence, Italy.
Perretti
F
F
Tramontana
M
M
Manzini
S
S
Geppetti
P
P
D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000378:metabolism*; D001920:Bradykinin / Q000494:pharmacology*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D002211:Capsaicin / Q000494:pharmacology*; D002339:Carotid Arteries / Q000187:drug effects / Q000378:metabolism; D008638:Mesenteric Arteries / Q000187:drug effects / Q000378:metabolism; D008642:Mesenteric Veins / Q000187:drug effects / Q000378:metabolism; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D051381:Rats; D014680:Veins / Q000187:drug effects / Q000378:metabolism*
D009240:N-Formylmethionine Leucyl-Phenylalanine; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin; D001920:Bradykinin