Caffeine-induced Ca2+ release inhibits GABAA responsiveness in rat identified native primary afferents.
It has been shown previously that an increase in cytoplasmic Ca2+ concentration depresses the GABA-A response. However, little attention has been paid to the Ca2+ source involved. In the present study, we show that the Ca2+ increase triggered by caffeine-induced Ca2+ release from the intracellular pool inhibits the GABA-A response, whereas Ca2+ influx through voltage-activated Ca2+ channels has no effect on this response.
Desaulles
E
E
Institut de Physiologie et de Chimie Biologique (CNRS URA 1446), Strasbourg, France.
Boux
O
O
Feltz
P
P
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D004558:Electric Stimulation; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects; D066298:In Vitro Techniques; D009475:Neurons, Afferent / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012433:Ryanodine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D012433:Ryanodine; D002110:Caffeine; D005680:gamma-Aminobutyric Acid; D002118:Calcium