Radioprotective effect of inosine and its enhancement by magnesium and global hypoxia.
The slight radioprotective action of inosine, when injected intraperitoneally to mice shortly before gamma-irradiation, can be enhanced by the administration of magnesium aspartate. This effect can be explained by the additivity of the vasodilatory actions of both agents. Inosine increases the radioprotective effectiveness of hypobaric hypoxia (10% O2), probably due to the additivity of the hypoxic effects in radiosensitive tissues. Acute hypoxic toxicity, however, is decreased by inosine administration. The cumulation of radioprotective effects of inosine and of its antihypoxic action in vitally important organs can have a favourable influence in hypoxic radiotherapy.
Pospísil
M
M
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Netíková
J
J
Pipalová
I
I
Volenec
K
K
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D005720:Gamma Rays; D006339:Heart Rate / Q000187:drug effects; D007288:Inosine / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010100:Oxygen / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D007288:Inosine; D008274:Magnesium; D010100:Oxygen