Barrier creams in the prevention of occupational contact dermatitis--an experimental study.
Experimental evaluation of two barrier creams has been carried out. One of these creams was composed of hydrocarbon components; the other had, in addition, silicone oil and cetaceum. The protective properties of these creams on rats and guinea pigs have been examined. It was found that investigated creams exerted an inhibiting effect on the absorption of chromium and nickel through the skin of rats from aqueous solutions. Moreover, the creams demonstrated a pronounced protective action on guinea pigs sensitized to chromium.
Starek
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Department of Industrial Toxicology, Medical Academy, Cracow, Poland.
D000818:Animals; D002857:Chromium / Q000493:pharmacokinetics; D003877:Dermatitis, Contact / Q000517:prevention & control*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009532:Nickel / Q000493:pharmacokinetics; D009784:Occupational Diseases / Q000517:prevention & control*; D009824:Ointments / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012869:Skin Absorption / Q000187:drug effects*
D009824:Ointments; D002857:Chromium; D009532:Nickel