title: Combination chemotherapy with cisplatin and 5-fluorouracil 5-day infusion in the therapy of advanced gastric cancer: a phase II trial.
abstract: Fifty-six patients with measurable or evaluable advanced gastric cancer were treated with cisplatin, 100 mg/m2 in continuous infusion of 24 hours, and 5-fluorouracil, 1000 mg/m2/day (by continuous 5-day infusion) every 4 weeks. Three patients were found ineligible for the study. A response rate of 41% (22/53) was obtained (95% confidence interval: 28%-54%), with a median duration of remission of 10.2 months and an overall median survival time of 10.6 months. Leukopenia and thrombocytopenia were mild. Nausea and vomiting were common, and 23.5% of the patients had grade 3 stomatitis. Peripheral neuropathy and renal insufficiency increased with the number of cycles, representing the cumulative dose-limiting toxicity. This study indicates that the combination of cisplatin plus 5-fluorouracil is synergistic or at least has additive antitumor activity. We think that this association of 2 drugs should be considered for further phase III clinical trials.
authors.affiliation: Servicio de Oncología Médica, Hospital General de Asturias, Oviedo, Spain.
authors.forename: A J
authors.initials: AJ
authors.lastname: Lacave
authors.forename: F J
authors.initials: FJ
authors.lastname: Barón
authors.forename: L M
authors.initials: LM
authors.lastname: Antón
authors.forename: E
authors.initials: E
authors.lastname: Estrada
authors.forename: L M
authors.initials: LM
authors.lastname: De Sande
authors.forename: I
authors.initials: I
authors.lastname: Palacio
authors.forename: E
authors.initials: E
authors.lastname: Esteban
authors.forename: J M
authors.initials: JM
authors.lastname: Gracia
authors.forename: J M
authors.initials: JM
authors.lastname: Buesa
authors.forename: O A
authors.initials: OA
authors.lastname: Fernández
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy*
chemical_list: D002945:Cisplatin; D005472:Fluorouracil