Design of renin inhibitors containing conformationally restricted mimetics of the P1-P1' and P1 through P2' sites.
Williams
P D
PD
Merck, Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486.
Payne
L S
LS
Perlow
D S
DS
Holloway
M K
MK
Siegl
P K
PK
Schorn
T W
TW
Lynch
R J
RJ
Doyle
J J
JJ
Strouse
J F
JF
Vlasuk
G P
GP
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry; D011487:Protein Conformation; D012083:Renin / Q000737:chemistry; D000092502:Renin Inhibitors
D009842:Oligopeptides; D012083:Renin; D000092502:Renin Inhibitors; C051529:renin inhibitory peptide, 4-amino-5-cyclohexyl-3-hydroxypentanoic acid