[Heparin effect on prevention of pelvic adhesions. Experimental study].
Thirty-one mongrel female dogs were submitted to a standard lesion on the right uterine horn, consisting of crushing, scratching, and ischemia of the segment. Three groups were formed for the study: control group (GC), experimental group I (G1), and experimental group II (G2). In GC, continuous washing with simple ringer solution was applied during surgery. In G1, heparin was added to the ringer solution at a doses of 100 IU/kg. In G2, in addition to the heparin diluted in the ringer solution, subcutaneous heparin was given at 12 hours intervals for three days, at a doses of 100 IU/kg/doses. The percentage of dogs with pelvic adhesions was determined by laparotomy. Adhesion intensity in the incision and in the pelvis was determined. 100% of dogs in G2 had adhesions in the incision, whereas 66.66% had incision adhesion in GC. There was no statistical difference. All groups presented around 50% of pelvic adhesions. Intensity of pelvic adhesions was not different in the three groups, but G2 had more adhesions than GC, such difference being statistically significant.
Florêncio
R de S
Rde S
Departamento de Ginecologia, Escola Paulista de Medicina, São Paulo.
Baracat
E C
EC
Focchi
J
J
de Lima
G R
GR
D000818:Animals; D004285:Dogs; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D000292:Pelvic Inflammatory Disease / Q000517:prevention & control*; D012996:Solutions; D000267:Tissue Adhesions / Q000517:prevention & control
D012996:Solutions; D006493:Heparin
Efeito da heparina na prevenção de aderências pélvicas. Estudo experimental.