title: Distal intramural spread in colorectal cancer: a reappraisal of the extent of distal clearance in fifty cases.
abstract: Fifty colorectal carcinomas were investigated to demonstrate distal intramural spread (DIS). In 17 cases (34%) a DIS ranging from 0.25 to 3.5 cm was present. DIS was positively correlated with stage C2 (p less than 0.01), lymph node metastasis (p less than 0.03) and infiltrative growth of the tumor (p less than 0.05). Our results show that DIS is a relatively frequent event but of limited extension. In fact, a distal clearance margin of 2 cm was considered safe for all patients but one C2 mucoid case. No pathologic feature can predict preoperatively the presence and extent of DIS.
authors.affiliation: Istituto di Anatomia e Istologia Patologica, Università degli Studi, Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Sidoni
authors.forename: A
authors.initials: A
authors.lastname: Bufalari
authors.forename: P F
authors.initials: PF
authors.lastname: Alberti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012004:Rectal Neoplasms / Q000473:pathology* / Q000601:surgery; D012811:Sigmoid Neoplasms / Q000473:pathology* / Q000601:surgery