title: Effect of early synovectomy on the course of rheumatoid arthritis.
abstract: Ninety-one patients with rheumatoid arthritis were retrospectively assigned to 3 subsets according to the number of joints with erosion (NJE). The subsets were least erosive (LES); more erosive (MES); most erosive involving multilating disease (MUD). In the early stages of disease the subsets were distinct (p less than 0.001) regarding mean values of annual reduction of carpal height (delta CHR) and serum Clq levels. Patient assessment (radiographic and clinical) continued to deteriorate in the MES and MUD subsets over the 1-5 year interval after synovectomy. Apparent stabilization of knee disease in the LES subset may be a feature of this subset rather than a result of synovectomy. Although synovectomy may offer short term symptomatic relief, we found no evidence that it retards the bony destruction or the disease process.
authors.affiliation: Department of Orthopedic Surgery, Osaka University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ochi
authors.forename: R
authors.initials: R
authors.lastname: Iwase
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: A
authors.initials: A
authors.lastname: Hirooka
authors.forename: K
authors.initials: K
authors.lastname: Masada
authors.forename: H
authors.initials: H
authors.lastname: Owaki
authors.forename: S
authors.initials: S
authors.lastname: Wakitani
authors.forename: N
authors.initials: N
authors.lastname: Murata
authors.forename: K
authors.initials: K
authors.lastname: Ono
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D015922:Complement C1q / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D011184:Postoperative Period; D011859:Radiography; D000074402:Synovectomy; D013997:Time Factors; D014953:Wrist / Q000000981:diagnostic imaging / Q000601:surgery
chemical_list: D015922:Complement C1q