Some new N-substituted alpha-aryl/alkyl succinimides as possible anticonvulsants.
In view of their expected MAO inhibitory CNS depressant and anticonvulsant properties a number of N-(5-alkyl-1,3,4-thiadiazol-2-yl)-alpha-aryl/alkyl succinimides (1-20) and N-(cyclohexyl)-alpha-aryl/alkyl succinimides (21-25) have been synthesized. Some of them when screened for anticonvulsant activity against pentetrazole induced seizures in mice at a dose of 80 mg/kg were found to be 10 to 50% active.
Amir
M
M
Department of Medicinal Chemistry, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
Singh
E
E
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D013388:Succinimides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000927:Anticonvulsants; D008996:Monoamine Oxidase Inhibitors; D013388:Succinimides; D010433:Pentylenetetrazole