[Biochemical and histological changes after acute oral poisoning with the acetanilide herbicide acetochlor].
Changes in the liver of male rats were studied on the 1, 3, 5, 7, 10 and 14 days after a single oral application of 1/5 DL 50 of the chloracetanilic herbicide Acetochlor (DL50 = 1063 mg/kg-1). Two main periods in the action of acetochlor can be identified: between 1-2 days when the influence of the compound itself is predominant and between 5-7 days, when the toxic action of the slowly eliminated metabolites is most pronounced. These two periods provoke a biphasic activation/inhibition response of the liver. Remarkable is the compensatory effect of the cytochrome P-450 system responsible for the metabolism of acetochlor. The phase-specific changes were are followed by pathomorphological observations of liver tissue as well as by the time-course of the biochemical parameters studied in different liver fractions.
Antov
G
G
Zaikov
C
C
Bouzidi
A
A
Mitova
S
S
Michaelova
A
A
Halkova
J
J
Choumkov
N
N
D000284:Administration, Oral; D000818:Animals; D006540:Herbicides / Q000008:administration & dosage / Q000506:poisoning*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D011041:Poisoning / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D014052:Toluidines / Q000008:administration & dosage / Q000506:poisoning*
D006540:Herbicides; D014052:Toluidines; C043377:acetochlor
Modifications biochimiques et histologiques de l'intoxication orale aiguë par l'herbicide acétanilidique "acétochlore".