Optimal antibody-radionuclide combinations for clinical radioimmunotherapy: a predictive model based on mouse pharmacokinetics.
A theoretical comparison was made of radioimmunotherapy (RIT) dosimetry estimates for eight radionuclides (90Y, 105Rh, 131I, 153Sm, 186Re, 188Re, 198Au, 211At) conjugated to IgG, F(ab')2, and Fab antibody forms. Antibody pharmacokinetics, derived from a nude mouse animal model were combined with appropriate physical data and S values to evaluate absorbed dose to a 0.5 kg centrally located tumor, total body and kidney. Radioimmunoconjugates of F(ab')2 with 90Y, 153Sm and 186Re were predicted to be the most promising for RIT.
Yorke
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ED
Division of Radiation Oncology & Biophysics, George Washington University Medical Center, Washington, DC 20037.
Beaumier
P L
PL
Wessels
B W
BW
Fritzberg
A R
AR
Morgan
A C
AC
D000818:Animals; D000906:Antibodies; D000911:Antibodies, Monoclonal / Q000276:immunology; D001853:Bone Marrow / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007668:Kidney / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D008954:Models, Biological; D009368:Neoplasm Transplantation / Q000276:immunology; D016499:Radioimmunotherapy; D011868:Radioisotopes / Q000493:pharmacokinetics
D000906:Antibodies; D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D011868:Radioisotopes