[Synthesis of heterocyclic immunomodulators. 1. Alkyl derivatives of 1,2,4-dithiazolidin-3,5-diyliden-bis(o-benzoquinone-meth ide): synthesis and testing of immunomodulating action].
Reactions of 1,2,4-dithiazolidine-3,5-diylidene-bis(o-benzoquinone-met hid) 3 with alkyl and substituted benzyl or phenacyl halides yield 1,2,4-dithiazol-3-ylidene-quinone-methides 4a-4i. Mass spectral fragmentations of 4a, 4c, and 4f are discussed. Tests for immunomodulating properties of 4a-c, 4e, and 4g are described. Some of these compounds show immuno-stimulatory activity.
Briel
D
D
Bereich Chemie biologisch aktiver Verbindungen, Universität Leipzig.
Leistner
S
S
Drössler
K
K
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D012882:Skin Tests; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D016227:Benzoquinones; D013844:Thiazoles
Synthese heterocyclischer Immunomodulatoren, 1. Mitt.: Alkylderivate von Prüfung auf immunomodulierende Wirkung.