Intestinal injury associated with spiramycin therapy of Cryptosporidium infection in AIDS.
Two of three patients treated with high doses of spiramycin for Cryptosporidium infection developed acute intestinal injury. Spiramycin at high doses may be directly toxic to the intestinal epithelium and thus may have limited utility as therapy for cryptosporidiosis in AIDS patients.
Weikel
C
C
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Lazenby
A
A
Belitsos
P
P
McDewitt
M
M
Fleming
H E
HE
Barbacci
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D003049:Coccidiostats / Q000009:adverse effects* / Q000627:therapeutic use; D003457:Cryptosporidiosis / Q000150:complications / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006679:HIV Seropositivity / Q000150:complications; D006801:Humans; D007422:Intestines / Q000187:drug effects*; D008297:Male; D015572:Spiramycin / Q000009:adverse effects* / Q000627:therapeutic use
D003049:Coccidiostats; D015572:Spiramycin