title: Regional brain perfusion changes in patients with primary generalized epilepsy assessed by Tc99m HM-PAO and SPECT.
abstract: Cerebral distribution of Tc99m-hexamethylprolenaminoxim (HMPAO) was investigated using single photon emission computerized tomography (SPECT) in 34 patients with primary generalized epilepsy (PGE) during the interictal state. These findings were compared with those in a control group of 9 healthy volunteers. In control subjects uniform selective uptake of HMPAO in cortex, basal ganglia and thalamus was found. In 30 patients (88%) decreased regional perfusion was found as follows: in the cortical region in 6 patients (18%), in the region of the basal ganglia or thalamus in 7 (20%), and in both regions in 17 patients (50%). Four patients had normal SPECT findings. The obtained results permit a hypothesis that the PGE should not be strictly differentiated from the focal epilepsy. A possible explanation of the pathophysiology of PGE has also been discussed.
authors.affiliation: University Hospital Lund, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Bajc
authors.forename: M
authors.initials: M
authors.lastname: Basić
authors.forename: S
authors.initials: S
authors.lastname: Hajnsek
authors.forename: N
authors.initials: N
authors.lastname: Topuzović
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002560:Cerebrovascular Circulation; D002648:Child; D004829:Epilepsy, Generalized / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime