Proton NMR imaging of cerebral blood flow using H2(17)O.
Cerebral blood flow was quantitatively mapped by monitoring the cerebral washout of H2(17)O using rapid, single-shot proton NMR imaging. H2(17)O acts as a freely diffusible contrast agent for proton imaging via its scalar-coupled term, enhancing T2 relaxation. Measured values for CBF ranged from 29 to 106 ml/min/100 g over a range of arterial pCO2 between 23 and 81 Torr.
Kwong
K K
KK
Department of Radiology, Massachusetts General Hospital, Charlestown 02129.
Hopkins
A L
AL
Belliveau
J W
JW
Chesler
D A
DA
Porkka
L M
LM
McKinstry
R C
RC
Finelli
D A
DA
Hunter
G J
GJ
Moore
J B
JB
Barr
R G
RG
D000818:Animals; D002560:Cerebrovascular Circulation; D004285:Dogs; D009682:Magnetic Resonance Spectroscopy; D010103:Oxygen Isotopes; D014867:Water
D010103:Oxygen Isotopes; D014867:Water