[The evaluation of the efficacy of carbamazepine and valproic acid in the alcohol postintoxication syndrome based on ethanol and acetaldehyde kinetics and the content of biogenic monoamines].
The effects of carbamazepine and valproic acid on disturbances of behaviour, elimination of ethanol, acetaldehyde from the blood, the contents of adrenaline, noradrenaline, dopamine, serotonin, 5-hydroxyindoleacetic acid and histamine in the brain and blood in alcoholic postintoxication syndrome were studied on male albino rats. Carbamazepine and valproic acid were shown to reduce the behavioural manifestations of the syndrome, to increase elimination of ethanol and acetaldehyde, to normalize the levels of the mediators in the brain tissues, particularly in the thalamus.
Mitina
L V
LV
Khokhlov
A L
AL
D000079:Acetaldehyde / Q000493:pharmacokinetics*; D000435:Alcoholic Intoxication / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002220:Carbamazepine / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D013577:Syndrome; D013997:Time Factors; D014635:Valproic Acid / Q000627:therapeutic use*
D015306:Biogenic Monoamines; D002220:Carbamazepine; D000431:Ethanol; D014635:Valproic Acid; D000079:Acetaldehyde; D003975:Diazepam
Otsenka éffektivnosti karbamazepina i val'proevoĭ kisloty pri alkogol'nom postintoksikatsionnom sindrome po kinetike étanola i atsetal'degida i soderzhaniiu biogennykh monoaminov.