[Synthesis and properties of DNA-duplexes, containing 9-(1'-hydroxy-2'-(hydroxymethyl)ethoxy)methylguanine].
Phosphoramidite derivative of 9-[1'-hydroxy-2'-(hydroxymethyl)ethoxy]methylguanine (glG) is synthesized which allows one to introduce point modifications in any position of the chemically prepared oligonucleotide chain. Oligonucleotides with 5'-terminal glG can be used in chemical ligation promoted by cyanogen bromide. The modified oligonucleotide duplexes were characterized by melting curves and CD spectra.
Romanova
E A
EA
Kuznetsova
L G
LG
Kubareva
E A
EA
Tsytovich
A V
AV
Merenkova
I N
IN
Oretskaia
T S
TS
Gromova
E S
ES
Shabarova
Z A
ZA
D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D008969:Molecular Sequence Data; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D009692:Nucleic Acid Heteroduplexes; D004247:DNA
Sintez i svoĭstva DNK-dupleksov, soderzhashchikh 9-(1'-gidroksi-2'-(gidroksimetil)étoksi)metilguanin.