[Activity of erythrocyte complement receptors class 1 in various kidney diseases].
The activity of the erythrocyte complement receptors type 1 (CR1) was measured in four groups: a control group--42 healthy persons, 18 patients with lupus nephritis (morphologic types: membranous, membranoproliferative, and proliferative), 16 patients with primary idiopathic membranous glomerulonephritis (GN), 20 patients with primary idiopathic membranoproliferative GN, and 23 chronic haemodialysis patients, in 20 of them the cause of the end-stage renal failure was primary idiopathic GN. The erythrocyte CR1 activity was determined by the immune adherence test. In the groups of the lupus nephritis and of the end-stage renal failure was observed a significant drop in erythrocyte CR1 activity. On the contrary the patients with primary idiopathic membranous and membranoproliferative GN exhibited a significantly greater erythrocyte CR1 activity than the normals.


CONCLUSIONS
1. The genetic predisposition to primary idiopathic GN is not reflected on the level of the erythrocyte CR1 system, what is distinct from the situation occurred in lupus nephritis, despite similarities in their immunopathogenesis. 2. The development of the end-stage renal failure in the course of primary idiopathic GN shows a inhibitory effect on erythrocyte CR1 activity.
Klinger
M
M
Kliniki Nefrologii AM we Wrocławiu.
Słowik
E
E
Kopeć
W
W
D000293:Adolescent; D000328:Adult; D003172:Complement C1 / Q000032:analysis / Q000276:immunology*; D004910:Erythrocyte Membrane / Q000276:immunology*; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000097:blood*; D015433:Glomerulonephritis, Membranous / Q000097:blood*; D006801:Humans; D007104:Immune Adherence Reaction / Q000379:methods; D008181:Lupus Nephritis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011951:Receptors, Complement / Q000032:analysis / Q000276:immunology*
D003172:Complement C1; D011951:Receptors, Complement
Aktywność erytrocytarnych receptorów klasy 1 dla dopełniacza w róznych chorobach nerek.