title: The role of oxygen free radicals in myocardial ischemia/reperfusion injury.
abstract: A series of experiments have been done to investigate the role of oxygen free radicals in ischemia/reperfusion injury. The following results were found: Myocardial MDA content increased significantly after post-ischemic reperfusion in vivo and in vitro. A blockade of the xanthine oxidase pathway for free radical generation could provide effective protection against ischemia/reperfusion injury. Exogenous reactive oxygen intermediates H2O2, .OH and O2- could induce changes in the contractility and electrophysiological properties of myocardial cells similar to those seen in ischemia/reperfusion. An outburst of free radical generation was detected by ESR spectroscopy at low temperature (-173 degrees C) and with the spin trapping technique during the very early phase of reperfusion. The authors emphasize the important role of free radicals in the pathogenesis of myocardial ischemia/reperfusion injury.
authors.affiliation: Cardiovascular Institute, CAMS, Beijing.
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Zhu
authors.forename: H
authors.initials: H
authors.lastname: Ju
authors.forename: J
authors.initials: J
authors.lastname: Hao
authors.forename: Z
authors.initials: Z
authors.lastname: Lai
authors.forename: C
authors.initials: C
authors.lastname: Zou
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Zhao
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000200:Action Potentials; D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D016166:Free Radical Scavengers; D006168:Guinea Pigs; D007166:Immunosuppressive Agents / Q000494:pharmacology; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000378:metabolism* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000502:physiology*; D010210:Papillary Muscles / Q000187:drug effects; D011817:Rabbits; D051381:Rats
chemical_list: D016166:Free Radical Scavengers; D007166:Immunosuppressive Agents; D008054:Lipid Peroxides; D008315:Malondialdehyde; C010192:9-(2-hydroxy-3-nonyl)adenine; D000225:Adenine; D010100:Oxygen