Synthesis of some 5-azaflavones.
Within a plan of researches concerning drugs with anti-ulcer activity, a series of 5-azaflavones has been prepared. In this first communication we report the relevant synthesis obtained by cyclization of appropriate beta-diketones in HCOOH at the boiling point. The beta-diketones have been obtained by Claisen condensation, starting from methyl 3-hydroxypicolinate and from appropriate aromatic or heterocyclic methylketone, using NaH as base.
Passarotti
C
C
Formenti Group, Research Laboratories, Origgio, VA, Italy.
Bandi
G L
GL
Citerio
L
L
Valenti
M
M
D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001372:Aza Compounds / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D005419:Flavonoids / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D001372:Aza Compounds; D005419:Flavonoids