Effects of ethyl 4-chloro-2-methylphenoxyacetate on hepatic peroxisomal enzymes in rats.
Effects of ethyl 4-chloro-2-methylphenoxyacetate (MCPA) and clofibrate on the activities of hepatic lipid metabolizing enzymes in the peroxisomal fraction from rat liver were studied, and these drugs were found to potentiate the peroxisomal enzyme activity. The results imply that MCPA affects lipid metabolism as well as clofibrate.
Inomata
N
N
Toxicology Section, Central Research Laboratories, Hokuriku Seiyaku Co., Ltd., Fukui.
Yoshida
H
H
Aoki
Y
Y
Tsunoda
M
M
Yamamoto
M
M
D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis; D001661:Biliary Tract Neoplasms / Q000139:chemically induced; D002994:Clofibrate / Q000633:toxicity; D006540:Herbicides / Q000633:toxicity*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D001647:Bile Acids and Salts; D006540:Herbicides; D008456:2-Methyl-4-chlorophenoxyacetic Acid; D002994:Clofibrate