[An experimental study of ADP-ribosylation inhibitors as anti-influenza agents].
Tri-substituted benzamide derivatives are described as a new class of antiviral drugs. Three compounds (3, N-acetylaminobenzamide, 3, N-butyrylaminobenzamide, and 3-methoxybenzamide) protected mice inoculated with influenza type A virus. 3, N-acetylaminobenzamide was found to be most active. It is suggested that the antiviral effect may be due to the specific inhibitory action of these compounds on NAD(+)-dependent ADP-ribosylation.
Vladimirov
V G
VG
Krasil'nikov
I I
II
Volgarev
A P
AP
Platonov
V G
VG
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use* / Q000633:toxicity; D001549:Benzamides / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D009980:Influenza A virus; D007928:Lethal Dose 50; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000401:mortality; D011064:Poly Adenosine Diphosphate Ribose / Q000037:antagonists & inhibitors*
D000998:Antiviral Agents; D001549:Benzamides; D011064:Poly Adenosine Diphosphate Ribose
Eksperimental'noe izuchenie nekotorykh ingibitorov ADF-ribozilirovaniia v kachestve protivogrippoznykh sredstv.