Solid phase synthesis of the fibronectin glycopeptide V(Gal beta 3GalNAc alpha)THPGY, its beta analogue, and the corresponding unglycosylated peptide.
The fibronectin fragment VTHPGY and the corresponding glycopeptides V(Gal beta 3GalNAc alpha)THPGY and V(Gal beta 3GalNAc beta)THPGY were synthesized by the FMOC/solid phase approach. FMOC derivatives of threonine, carrying O-linked, peracetylated Gal beta 3GalNAc chains were used for introduction (HOBt-mediated coupling) of the disaccharide moieties.
Lüning
B
B
Department of Organic Chemistry, Stockholm University, Sweden.
Norberg
T
T
Rivera-Baeza
C
C
Tejbrant
J
J
D000595:Amino Acid Sequence; D002240:Carbohydrate Sequence; D005353:Fibronectins / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis*; D006031:Glycosylation; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis*
D005353:Fibronectins; D006020:Glycopeptides; D010446:Peptide Fragments; C076289:Val(galactosyl-3-galactosyl-N-acetyl)Thr-His-Pro-Gly-Tyr