title: Are rats with genetic absence epilepsy behaviorally impaired?
abstract: Absence seizures in humans are characterized by unresponsiveness to external stimuli and inactivity. However, in typical generalized non-convulsive epilepsy in children, intellectual capacities are considered to be normal. Wistar rats from an inbred strain with spontaneous absence-like seizures were compared with rats from the outbred control strain in various behavioral tasks in order to detect possible impairments related either to the absence epilepsy or to occurrence of spike and wave discharges (SWD). Spontaneous circadian locomotion, exploratory activity in an open field, social interactions with an unfamiliar conspecific and mouse killing behavior were similar in both strains. Avoidance learning in a shuttle box or food reinforced learning in a Skinner test were unimpaired or even improved in epileptic rats. During performance of a learned task either in the Skinner box or in a conditioned sound-bar pressing task, SWD were suppressed in epileptic rats as long as they were working for reinforcement. SWD reappeared when the motivation to perform the task had declined: unresponsiveness to a conditioned stimulus was then observed during SWD. These data are in agreement with observations commonly described in children with typical genetic absence epilepsy.
authors.affiliation: Centre de Neurochimie, CNRS, Strasbourg, France.
authors.forename: M
authors.initials: M
authors.lastname: Vergnes
authors.forename: C
authors.initials: C
authors.lastname: Marescaux
authors.forename: A
authors.initials: A
authors.lastname: Boehrer
authors.forename: A
authors.initials: A
authors.lastname: Depaulis
mesh_terms: D000374:Aggression / Q000502:physiology; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D003216:Conditioning, Operant / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects; D004832:Epilepsy, Absence / Q000235:genetics / Q000523:psychology*; D005106:Exploratory Behavior / Q000502:physiology; D007858:Learning / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012919:Social Behavior