Controlled ovarian hyperstimulation as a risk factor for ectopic pregnancy.
As part of a case-control study of ectopic pregnancy, we evaluated the potential etiologic role of controlled ovarian hyperstimulation in a population with no previous history of ectopic pregnancy. Ovulation induction alone was associated with an increased risk of ectopic pregnancy (adjusted odds ratio = 3.98; 95% confidence interval 1.10-14.30). In contrast, ovulation induction for in vitro fertilization did not increase the risk further (adjusted odds ratio = 2.45; 95% confidence interval 0.54-11.13). These results suggest that hormonal factors may be involved in the development of ectopic pregnancy.
Fernandez
H
H
Department of Gynecology and Obstetrics, Hôpital A. Béclère, Clamart, France.
Coste
J
J
Job-Spira
N
N
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D016015:Logistic Models; D010062:Ovulation Induction / Q000009:adverse effects*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000209:etiology*; D012307:Risk Factors