title: [Thyrotropin-releasing hormone: distribution, role and importance].
abstract: TRH is one of the first hypothalamic releasing hormones which has been identified and applied in humans. It is a tripeptidamid which belongs to the family of neuropeptides together with endorphins, neurotensin and substance P. TRH is widely distributed not only in hypothalamus, but also in extrahypothalamic parts of CNS as well as in many peripheral tissues and organs. TRH receptors are one of the first discovered peptide receptors in the brain. TRH coexists with other neurotransmitters and neuromodulators in brain neurons. In addition to its endocrine function in the regulation of TSH secretion, it also releases prolactin, FSH and NOR. Moreover, its extrapituitary actions have not yet been fully elucidated. Although TRH receptors are identified in CNS, it is not yet known whether it is a neurotransmitter or a neuromodulator. In particular, its relationship with cholinergic, noradrenergic, dopaminergic, serotonergic and opioid systems as well as other putative neurotransmitters in the brain, has been discussed. Finally, TRH is used as a diagnostic means in some endocrine and nonendocrine disorders.
authors.affiliation: Department of Pharmacology, University School of Medicine, Belgrade.
authors.forename: D
authors.initials: D
authors.lastname: Jovanović-Mićić
authors.forename: R
authors.initials: R
authors.lastname: Samardzić
authors.forename: D
authors.initials: D
authors.lastname: Beleslin
mesh_terms: D000818:Animals; D006801:Humans; D013973:Thyrotropin-Releasing Hormone / Q000737:chemistry / Q000502:physiology
chemical_list: D013973:Thyrotropin-Releasing Hormone
vernacular_title: Oslobadjajunći hormon tireotropina: rasprostanjenost,uloga i znacaj.