[Study of the reproductive function in albino rats after inhalation of 4,4'-diaminodiphenyl ether of resorcin].
The article contains experimental data on the morphofunctional state of gonads in male rats after chronic inhalation of diamine P, and on the state of embryogenesis after inhalant introduction of diamine P into pregnant rats in threshold-level concentrations. Results of the study revealed that, in chronic inhalant introduction at 29.3 and 4.2 mg/m3, diamine P demonstrated gonadotoxic properties, which was proved by the higher percentage of dead spermatozoa and spermatogonium diseases. The changes in the gonads' state reflected the pathological processes caused by diamine P in the animals due to the general toxicity properties of the substance. The embryotoxic effect of diamine P in inhalations at 5 mg/m3 (close to the threshold levels of total toxicity) was not statistically relevant.
Vasilenko
N M
NM
Khipko
S E
SE
Paranich
L I
LI
Omel'chenko
O A
OA
D000280:Administration, Inhalation; D000818:Animals; D000988:Antispermatogenic Agents / Q000008:administration & dosage / Q000633:toxicity*; D003864:Depression, Chemical; D008297:Male; D008954:Models, Biological; D010647:Phenyl Ethers / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D012118:Resorcinols / Q000008:administration & dosage / Q000633:toxicity*; D013076:Sperm Count / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects* / Q000502:physiology; D013094:Spermatozoa / Q000187:drug effects*
D000988:Antispermatogenic Agents; D010647:Phenyl Ethers; D012118:Resorcinols; C015126:di-(4-aminophenyl)ether; C031389:resorcinol
Issledovanie reproduktivnoĭ funktsii belykh krys pri ingaliatsionnom vozdeĭstvii 4,4'-diaminodifenilovogo éfira resortsina.