Bicascarosides in fluid extracts of cascara.
Bianthraquinone glycosides are formed during the preparation and conservation of fluid extracts of cascara. Analysis of these preparations has shown that up to 20% of total amount of anthracene glycosides can be dimerized. These dimers are devoid of laxative activity. They are absorbed in the intestine and very slowly excreted.
de Witte
P
P
Laboratory of Pharmaceutical Biology and Phytopharmacology, Institute of Pharmaceutical Sciences, K.U. Leuven, Belgium.
Cuveele
J
J
Lemli
J
J
D000818:Animals; D002400:Cathartics / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D031955:Rhamnus / Q000494:pharmacology
D002400:Cathartics; D005960:Glucosides; D010936:Plant Extracts