Increased susceptibility to peroxide-induced haemolysis with normal vitamin E concentrations in cystic fibrosis.
Vitamin E status was assessed in 22 patients with cystic fibrosis and 9 controls by measuring concentrations of the vitamin, vitamin E:lipid ratios and peroxide-induced haemolysis in plasma and erythrocytes. For a given concentration of plasma or erythrocyte alpha-tocopherol, erythrocytes of patients with cystic fibrosis were more susceptible to peroxide-induced haemolysis than controls. This susceptibility should be countered by supplementation with vitamin E to maintain higher than normal concentrations of circulating alpha-tocopherol-greater than 4.8 mmol alpha-tocopherol/mol cholesterol.
James
D R
DR
Department of Medical Biochemistry, University Hospital of Wales, Cardiff, UK.
Alfaham
M
M
Goodchild
M C
MC
D000293:Adolescent; D016718:Arachidonic Acid / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D003550:Cystic Fibrosis / Q000097:blood* / Q000188:drug therapy; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D010545:Peroxides / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use
D008041:Linoleic Acids; D008055:Lipids; D010545:Peroxides; D014280:Triglycerides; D014810:Vitamin E; D016718:Arachidonic Acid; D002784:Cholesterol; D019787:Linoleic Acid