[Observation of three anti-M. tuberculosis antibodies in children with tuberculosis during chemotherapy].
Earlobe blood from 122 children with tuberculosis and 187 healthy children were assayed for anti-OTIgG, anti-PPDIgG and anti-Ag6IgG by ABC-ELISA. We found that the mean levels and sensitivity of anti-OTIgG and anti-PPDIgG decreased significantly in patients receiving more than 3 months of chemotherapy, but the anti-Ag6IgG remained constant. 18 patients were followed up for 12 months. among them 6 patients had a conversion from negative of anti-Ag6IgG to positive results. It is suggested that IgG to various M. tuberculosis antigens changes differently during the chemotherapy.
Zheng
Y J
YJ
Pediatric Department Xijing Hospital Fourth Military Medical University, Xian.
D000907:Antibodies, Bacterial / Q000097:blood*; D000918:Antibody Specificity; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007223:Infant; D014373:Tuberculin / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology*
D000907:Antibodies, Bacterial; D014373:Tuberculin