title: Interleukin-1 beta regulation of islet and thyroid autoimmunity in the BB rat.
abstract: Daily injections of high dose human recombinant interleukin-1 beta (IL-1 beta) accelerated the onset of both insulin-dependent diabetes mellitus and lymphocytic thyroiditis in genetically prone BB rats. In diabetes-resistant BB rats, high dose IL-1 beta failed to induce diabetes. Additionally, the presence of neutralizing IL-1 beta antibodies in these rats strongly correlated with inhibition of lymphocytic thyroiditis. Since low dose IL-1 beta protects diabetes-prone rats from IDDM, we conclude that IL-1 beta is a potent modulator of autoimmune diabetes and thyroid disease in genetically susceptible rats.
authors.affiliation: University of Washington, Department of Medicine, Seattle 98195.
authors.forename: S
authors.initials: S
authors.lastname: Vertrees
authors.forename: C A
authors.initials: CA
authors.lastname: Wilson
authors.forename: R
authors.initials: R
authors.lastname: Ubungen
authors.forename: D
authors.initials: D
authors.lastname: Wilson
authors.forename: D G
authors.initials: DG
authors.lastname: Baskin
authors.forename: B
authors.initials: B
authors.lastname: Toivola
authors.forename: C
authors.initials: C
authors.lastname: Jacobs
authors.forename: N
authors.initials: N
authors.lastname: Boiani
authors.forename: P
authors.initials: P
authors.lastname: Baker
authors.forename: A
authors.initials: A
authors.lastname: Lernmark
mesh_terms: D000311:Adrenal Glands / Q000033:anatomy & histology; D000367:Age Factors; D000818:Animals; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D005856:Germ-Free Life; D007274:Injections, Intraperitoneal; D007375:Interleukin-1 / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000276:immunology*; D007668:Kidney / Q000033:anatomy & histology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000033:anatomy & histology; D051381:Rats; D011913:Rats, Inbred BB; D011994:Recombinant Proteins / Q000276:immunology; D013154:Spleen / Q000033:anatomy & histology; D013950:Thymus Gland / Q000033:anatomy & histology; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000139:chemically induced / Q000276:immunology; D013974:Thyroxine / Q000097:blood
chemical_list: D007375:Interleukin-1; D011994:Recombinant Proteins; D013974:Thyroxine