title: A pilot follow-up study of childhood soft signs and the development of adult psychopathology.
abstract: A subgroup of subjects (4 of 12) with childhood soft signs and adolescent anxiety-withdrawal disorders were followed up into adulthood and assessed for soft signs and psychiatric diagnoses. These subjects continued to have soft-sign abnormalities and most had adult anxiety or affective disorders, including obsessive-compulsive disorder (OCD). In contrast, control subjects with childhood soft signs but no adolescent anxiety disorders had fewer soft signs at follow-up and no discrete adult anxiety or affective disorders, but they did have obsessive-compulsive symptoms that did not meet criteria for OCD.
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
authors.forename: E
authors.initials: E
authors.lastname: Hollander
authors.forename: C M
authors.initials: CM
authors.lastname: DeCaria
authors.forename: B
authors.initials: B
authors.lastname: Aronowitz
authors.forename: D F
authors.initials: DF
authors.lastname: Klein
authors.forename: M R
authors.initials: MR
authors.lastname: Liebowitz
authors.forename: D
authors.initials: D
authors.lastname: Shaffer
mesh_terms: D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000503:physiopathology; D002648:Child; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D009460:Neurologic Examination; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D010553:Personality Development; D010865:Pilot Projects