Measurement of quinine in filter paper-absorbed blood by high-performance liquid chromatography.
An adaptation of an existing high-performance liquid chromatographic assay is described for the measurement of quinine, within the therapeutic concentration range, in whole blood. This method, in particular the use of small blood samples which have been dried onto filter paper strips, has advantages for clinical and pharmacokinetic studies in the tropics on children with malaria.
Mberu
E K
EK
Kenya Medical Research Institute, Nairobi.
Ward
S A
SA
Winstanley
P A
PA
Watkins
W M
WM
D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008288:Malaria / Q000097:blood; D011803:Quinine / Q000097:blood*; D015203:Reproducibility of Results
D011803:Quinine