Clinical study on pharmacological interaction between nimesulide and warfarin.
This article describes the pharmacological interaction between nimesulide, a recently introduced non-steroidal anti-inflammatory drug, and warfarin, an indirect anticoagulant. The aim of the study was to demonstrate if nimesulide could potentiate the activity of this anticoagulant drug, as previously shown by some authors. Ten patients, who were taking 5 mg/day of warfarin, were treated with nimesulide 100 mg twice a day, for seven days: the association of the two drugs did not alter, in a statistical way, neither prothrombin time, nor partial thromboplastin time, nor fibrinogenemia, nor bleeding time. The findings showed that, in a short-term treatment, there was no bleeding risk in combining warfarin with nimesulide.
Auteri
A
A
Division of Clinical Immunology and Allergology, University of Siena, Italy.
Bruni
F
F
Blardi
P
P
Di Renzo
M
M
Pasqui
A L
AL
Saletti
M
M
Verzuri
M S
MS
Scaricabarozzi
I
I
Vargiu
G
G
Di Perri
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004347:Drug Interactions; D004361:Drug Tolerance; D006801:Humans; D008875:Middle Aged; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D014859:Warfarin / Q000008:administration & dosage / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D014859:Warfarin; C012655:nimesulide