Redox changes in insulin-dependent diabetes mellitus.
The present work evaluates some aspects of the redox potential in individuals with insulin-dependent diabetes mellitus (IDDM). The plasma lipid peroxides level and the concentration of glutathione (GSH) were measured. The data obtained revealed a rise in lipoperoxides concentration and a decrease in GSH content suggesting that oxygen derived free radicals may play a role in the pathogenesis of IDDM.
Dinu
V
V
Department of Biochemistry, Institute of Medicine and Pharmacy, Bucharest, Romania.
Zamfir
O
O
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005978:Glutathione / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D010084:Oxidation-Reduction
D008054:Lipid Peroxides; D005979:Glutathione Peroxidase; D005978:Glutathione