Multiple administration of carbamazepine, typical and atypical antidepressant drugs on clonidine-induced hypoactivity in mice.
The chronic effects of carbamazepine were compared with those of typical and atypical antidepressant drugs on clonidine--induced hypoactivity in mice. The results indicated that clonidine at a dose of 0.05-0.10-0.15 mg/kg i.p. produced a dose-dependent depressant effect on the exploratory behavior, as shown by the marked reduction in ambulation and rearing in an "open-field" test. Chronic pretreatment with imipramine 20 mg/kg i.p. and desipramine 5-10 mg/kg i.p. for 14 days resulted in a significant reduction in clonidine-induced hypoactivity. Repeated pretreatment with atypical antidepressant drugs (trazodone 5-10 mg/kg i.p.:, fluoxetine 5-10 mg/kg i.p., or rubidium chloride 24-48 mg/kg i.p.) as well as carbamazepine 10-20 mg/kg i.p., had no significant effect on clonidine-induced hypoactivity. In summary, these findings provide further evidence for a subsensitivity of presynaptic alpha 2-adrenoceptors in animals chronically treated with imipramine or desipramine and a behavioural profile of carbamazepine similar to that of atypical antidepressant drugs.
De Angelis
L
L
Institute of Pharmacology, School of Medicine, University of Trieste, Italy.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002220:Carbamazepine / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D003000:Clonidine / Q000009:adverse effects / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy*; D003891:Desipramine / Q000494:pharmacology; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology; D006948:Hyperkinesis / Q000188:drug therapy*; D007099:Imipramine / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity; D012413:Rubidium / Q000494:pharmacology; D014196:Trazodone / Q000494:pharmacology
D000928:Antidepressive Agents; D002712:Chlorides; D005473:Fluoxetine; D002220:Carbamazepine; D012413:Rubidium; D003000:Clonidine; C032710:rubidium chloride; D007099:Imipramine; D003891:Desipramine; D014196:Trazodone