An acidic polysaccharide having activity on the reticuloendothelial system from the root of Astragalus mongholicus.
An acidic polysaccharide, designated as AMon-S, was isolated from the roots of Astragalus mongholicus BUNGE. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.6 x 10(4). It showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: D-galactose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 18:18:1:1, in addition to small amounts of O-acetyl groups and peptide moiety. A part of the hexuronic acid residues exist as the methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features and revealed mainly alpha-arabino-beta-3,6-galactan type structural units.
Shimizu
N
N
Kyoritsu College of Pharmacy, Tokyo, Japan.
Tomoda
M
M
Kanari
M
M
Gonda
R
R
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D011134:Polysaccharides