Effect of UVB plus tar therapy on serum levels of interleukin-2 receptors in patients with psoriasis.
Baseline serum levels of interleukin-2 receptor (IL2R) were measured in 65 patients with active psoriasis. IL2R levels in psoriatic patients were significantly higher than in healthy controls (582.4 +/- 289.23 u/ml vs. 369.64 +/- 111.10 u/ml; P less than 0.05), but did not differ statistically from values found in an atopic dermatitis control group (619.88 +/- 254.27 u/ml). Sex, age and severity of the disease do not affect levels of IL2R. The same IL2R levels were measured in 26 psoriatic patients receiving UVB plus tar therapy. This therapy, continued until clinical remission, lowered IL2R levels to values comparable to controls. This decrease may be due to an immunosuppressive effect of therapy.
Betti
R
R
Dermatology Clinic, University of Milan, Italy.
Rosti
A
A
Lodi
A
A
Bencini
P L
PL
Paparelli
S
S
Gazzola
G B
GB
Cori
P
P
Moroni
G A
GA
Crosti
C
C
D000328:Adult; D000368:Aged; D003033:Coal Tar / Q000494:pharmacology*; D003876:Dermatitis, Atopic / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy; D015375:Receptors, Interleukin-2 / Q000032:analysis* / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays
D015375:Receptors, Interleukin-2; D003033:Coal Tar