QSAR approach to target organ estimation.
This paper summarizes attempts to apply QSAR analysis to the prediction of the distribution of xenobiotics and the target organ. Biosolubility is a property of xenobiotics which plays a dominant role in transport kinetics and distribution in the body. Biosolubility is related to tissue-gas partition coefficients and can be estimated from oil-gas and water-gas partition coefficients. The biosolubility ratios in individual tissues determine the distribution pattern of xenobiotics in the body. The tissue with the highest probability of being reached by a xenobiotic is a candidate target tissue.
Tichý
M
M
Institute of Hygiene and Epidemiology, Praha, Czechoslovakia.
D000818:Animals; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry / Q000493:pharmacokinetics; D012995:Solubility; D013329:Structure-Activity Relationship; D014018:Tissue Distribution; D015262:Xenobiotics / Q000737:chemistry / Q000493:pharmacokinetics*
D006843:Hydrocarbons, Chlorinated; D015262:Xenobiotics