Radiation carcinogenesis in mouse skin and its threshold-like response.
Experiments on the dose-response of tumor development induced by repeated local beta irradiation of the back of mice are summarized. Results indicated a 100% tumor incidence on irradiation at 2.5-11.8 Gy per exposure (dose-saturation effect) and the threshold-like dose response at lower doses. The mechanism underlying these phenomena is discussed on the basis of the tissue-misrepair model, that is misrepair caused by repeated stimulation of cell growth after repeated tissue injury.
Tanooka
H
H
Radiobiology Division, National Cancer Center Research Institute, Tokyo, Japan.
Ootsuyama
A
A
D000818:Animals; D001610:Beta Particles; D004307:Dose-Response Relationship, Radiation; D051379:Mice; D008815:Mice, Inbred Strains; D009381:Neoplasms, Radiation-Induced / Q000503:physiopathology*; D012878:Skin Neoplasms / Q000503:physiopathology*