title: Evaluation of a combined oral contraceptive pill in black Zimbabwean women.
abstract: A prospective exploratory study was carried out on lipid metabolism (41 women); as well as efficacy, acceptability and safety on another 190 women who all were using a combined oral contraceptive pill (OC) containing 30 micrograms Ethinyl oestradiol and 150mg Desogestrel (Marvelon) over a period of twelve months. The 41 women had blood analysis of triglycerides, cholesterol and high density lipoproteins (HDL) before treatment and at each of follow-up visits scheduled at 3, 6, 9 and 12 months following admission. Triglycerides, cholesterol and HDL levels were computed and there were no significant changes in any of the measured levels except HDL which was increased. No pregnancy was reported in one year of use in both groups. Cycle control was good, with a very low incidence of breakthrough bleeding and spotting being reported. The pill did not affect body weight and blood pressure significantly. It was concluded that the Marvelon formulation does not have adverse effect on lipid metabolism and is an efficacious and well tolerated contraceptive amongst Zimbabwean women.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Zimbabwe Medical School, Avondale, Harare.
authors.forename: J
authors.initials: J
authors.lastname: Kasule
authors.forename: M
authors.initials: M
authors.lastname: Mbizvo
authors.forename: D
authors.initials: D
authors.lastname: Makuyana
authors.forename: D
authors.initials: D
authors.lastname: Masona
mesh_terms: D000293:Adolescent; D000328:Adult; D001779:Blood Coagulation Factors / Q000032:analysis; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008111:Liver Function Tests; D014280:Triglycerides / Q000097:blood; D015030:Zimbabwe
chemical_list: D001779:Blood Coagulation Factors; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003277:Contraceptives, Oral, Combined; D008055:Lipids; D014280:Triglycerides