Reticuloendothelial system-potentiating and alkaline phosphatase-inducing activities of Plantago-mucilage A, the main mucilage from the seed of Plantago asiatica, and its five modification products.
Five kinds of chemically modified products were prepared from Plantago-mucilage A, the representative mucous polysaccharide isolated from the seed of Plantago asiatica L., and their reticuloendothelial system-potentiating and alkaline phosphatase-inducing activities have been investigated. Both activities were markedly enhanced when the mucilage was de-O-acetylated. The products obtained by periodate oxidation, controlled Smith degradation, and partial acid hydrolysis under the two conditions were not effective. Structural features of the partial hydrolyzates were elucidated, and it was shown that these products lost all O-acetyl groups, all xylose branches and many hexuronosyl arabinose side chains.
Tomoda
M
M
Kyoritsu College of Pharmacy, Tokyo, Japan.
Takada
K
K
Shimizu
N
N
Gonda
R
R
Ohara
N
N
D000269:Adhesives / Q000494:pharmacology*; D000469:Alkaline Phosphatase / Q000096:biosynthesis*; D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012157:Mononuclear Phagocyte System / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D010943:Plantago; D010946:Plants, Medicinal / Q000737:chemistry*
D000269:Adhesives; D000469:Alkaline Phosphatase