Toxicological evaluation of agromet (Metalaxyl) preparation.
A complex toxicological study was carried out in relation to the hygienic standardization of the fungicide preparation Ridomil, whose forthcoming production in this country will be under the name Metalaxyl. The study was performed on sexually mature white rats of both sexes, at oral, dermal and inhalation exposure, acute, subacute and chronic experiments, according to the Bulgarian State Standard. Besides the routine toxicological studies were carried also studies for establishing the long-term effects of the preparation (gonadotropic, embryotoxic and teratogenic, cardiovascular). The results from the study permitted the Agromet preparation to be put in III class--moderately toxic according to limiting index LD50 oral. On the basis of data from the authors study on the general toxicity and long-term effects of Metalaxyl a temporary MAC 4 mg/m3 was proposed.
Kaloyanova
F
F
Institute of Hygiene and Occupational Diseases, Sofia, Bulgaria.
Ivanova-Chemishanska
L
L
Zaykov
H R
HR
Baynova
A
A
Mihaylova
A
A
Mircheva
V
V
Anton
G
G
Shumkov
N
N
Vergieva
T
T
Halkova
Z H
ZH
D000409:Alanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000633:toxicity; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005659:Fungicides, Industrial / Q000633:toxicity*; D006066:Gonads / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013723:Teratogens
D005659:Fungicides, Industrial; D013723:Teratogens; C028175:metalaxyl; D000409:Alanine