title: Manometric and histologic assessment following proctocolectomy and straight enteroanal anastomosis in canines.
abstract: Serial manometric studies were performed in mongrel dogs before and after total colectomy, mucosal proctectomy and interposed jejunoanal anastomosis without pouch. Fecal continence and body weight gain were clinically satisfactory by 28 weeks after surgery. Even at 28 weeks after the mucosal proctectomy, the mean maximal resting anal sphincter pressure was significantly lower than the preoperative level (p less than 0.001). Neorectal compliance also decreased. The rectoanal inhibitory reflexes were not observed 2 weeks after the mucosal proctectomy but atypical to typical patterns gradually appeared up to 28 weeks following the mucosal proctectomy. Histologic examination showed no injury of anal sphincter muscles. Mild inflammation was found in the neorectal mucosal layer in all animals. Meissner's plexus in rectal muscular cuff was almost completely disrupted. These data suggested that there is certain limitation in restoration of anoneorectal function after mucosal protectomy and enteroanal anastomosis, though with gentle and careful operations.
authors.affiliation: Department of Surgery I, Kyushu University Faculty of Medicine, Fukuoka, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Mibu
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Nakahara
authors.forename: M
authors.initials: M
authors.lastname: Hotokezaka
authors.forename: F
authors.initials: F
authors.lastname: Nakayama
mesh_terms: D001003:Anal Canal / Q000473:pathology / Q000502:physiology* / Q000601:surgery; D000714:Anastomosis, Surgical; D000818:Animals; D004285:Dogs; D007583:Jejunum / Q000601:surgery*; D008365:Manometry; D016737:Proctocolectomy, Restorative