title: [Clinical effect and laboratory observation of ofloxacin in the treatment of typhoid fever, bacillary dysentery and gonorrhea].
abstract: Ofloxacin was used in the treatment of 20 cases of typhoid fever, 32 cases of bacillary dysentery and 50 cases of gonococcal infection. Altogether 102 cases were treated, 53 being male and 49 female. The daily dosage was 400 mg to 600 mg, divided into two times. The result showed that the clinical effective rate for typhoid fever, bacillary dysentery and gonococcal infections was 100%, 97% and 94% respectively, while the bacterial eradication rate was 100%, 100% and 94% respectively. the bacterial eradication rate was 100%, 97% and 94% respectively. The side effects were mild in degree. The authors are of the opinion that since ofloxacin can be administered orally with only two times a day, its absorption is nearly complete and the cure rate is high, it should be considered as the drug of choice in the treatment of typhoid fever, bacillary dysentery and gonorrhea, especially in the drug resistant cases. It is suggested that this drug be used more widely.
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital of Chongqing University of Medical Sciences.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Zou
authors.forename: Q N
authors.initials: QN
authors.lastname: Wang
authors.forename: Y F
authors.initials: YF
authors.lastname: Jiang
mesh_terms: D000328:Adult; D004405:Dysentery, Bacillary / Q000188:drug therapy*; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D015242:Ofloxacin / Q000494:pharmacology / Q000627:therapeutic use*; D012485:Salmonella typhi / Q000187:drug effects; D012762:Shigella dysenteriae / Q000187:drug effects; D014435:Typhoid Fever / Q000188:drug therapy*
chemical_list: D015242:Ofloxacin