title: [Experience with the use of immune intravenous immunoglobulin in symptomatic children with human immunodeficiency virus infection].
abstract: The Department of Pediatrics of the San Juan City Hospital participated in a collaborative clinical trial, placebo controlled, designed by NICHD with the purpose of determining if the use of gamma immunoglobulin is effective in preventing serious infections in symptomatic children infected with HIV. Of the 372 children randomized, 33 were from San Juan City Hospital. Of the 16 children on placebo, 9 (56%) developed 23 episodes of serious infections and 4 of 15 children on IVIG developed 5 episodes. A total of 24 hospitalizations occurred in the placebo group and six in the IVIG group. The mortality in our center was 12% (4/31). No adverse reactions were registered from the infusions in our center. Intravenous gamma immunoglobulin demonstrated to be effective in preventing bacterial infections and decreasing the number of hospitalizations in a subgroup of children infected with HIV.
authors.affiliation: Departamento de Pediatría, Hospital Municipal de San Juan, Puerto Rico.
authors.forename: E
authors.initials: E
authors.lastname: Jiménez
authors.forename: M T
authors.initials: MT
authors.lastname: Carrer
authors.forename: I
authors.initials: I
authors.lastname: Pérez Dieppa
authors.forename: L
authors.initials: L
authors.lastname: Ortiz
authors.forename: M
authors.initials: M
authors.lastname: Fernández
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D015658:HIV Infections / Q000401:mortality / Q000628:therapy*; D015497:HIV-1; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D011647:Puerto Rico
chemical_list: D016756:Immunoglobulins, Intravenous
vernacular_title: Experiencia con el uso de la gammaglobulina inmune intravenosa en niños sintomáticos con infección del virus de la inmunodeficiencia humana.