title: The development of tolerance to ataxia and to diuresis induced by ethanol in rats is not simultaneous.
abstract: The present study was conducted to determine whether behaviorally accelerated development of tolerance to the disruptive effects of ethanol on rotarod performance paralleled the development of tolerance to ethanol-induced diuresis and to determine the effect of pre- and post-training ethanol administration on the development of tolerance to both of these effects. Male Wistar rats were treated with ethanol (2 g kg-1 day-1, ip) over a period of 5 weeks under one of the following schemes: ethanol injections before training (pre-training ethanol group) or after training (post-training ethanol group). Control animals received 0.9% NaCl, ip, after training. The effect of ethanol on diuresis was assessed once a week. Data are reported as means +/- SEM of 6 animals. Significant tolerance to the uncoordinating effect of ethanol was detected from the 17th day of treatment onwards in animals of the pre-training ethanol group (2nd day = 1.7 +/- 0.6 s vs 17th day = 39.0 +/- 8.1 s, Student t-test for related samples) but was not observed in animals of the post-training ethanol group until 34 days of treatment (pre-training ethanol group = 56.1 +/- 8.5 s; post-training ethanol group = 29.8 +/- 9.6 s vs control group = 12.6 +/- 7.6 s, Newman-Keuls test).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brasil.
authors.forename: G S
authors.initials: GS
authors.lastname: Morato
authors.forename: A M
authors.initials: AM
authors.lastname: Rosas
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001259:Ataxia / Q000139:chemically induced*; D001522:Behavior, Animal / Q000187:drug effects*; D004231:Diuresis / Q000187:drug effects*; D004361:Drug Tolerance; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000431:Ethanol