[Plasma levels of adrenaline and noradrenaline, plasma renin activity and arterial blood pressure in patients after kidney transplantation].
In 64 kidney transplant patients (KTP) (35) treated by cyclosporine A (CyA)+ prednisone and 29 treated by azathioprine (Aza)+ prednisone and promethazine and in 15 healthy subjects plasma adrenalin (A), noradrenaline (NA), plasma renin activity (PRA) and mean arterial pressure (MAP) in basal conditions and after water immersion test (WI) were measured. In basal conditions the A and PRA were higher, but NA was normal. After WI statistically significant decrease of MAP, PRA, A and NA were observed in all examined groups. In KTP mean decrease MAP, PRA and A was higher, but NA lower than in normals. No significant correlation between A or NA and PRA, and MAP and A or NA was observed. In KTP the change in sympathetic+ activity was observed. Participation of catecholamines and renin in the pathogenesis of hypertension in KTP is not dominant. Kind of immunosuppressive therapy (CyA or Aza) haven't significant influence on A, NA nad PRA levels.
Zukowska-Szczechowska
E
E
Katedry i Kliniki Nefrologii Slaskiej Akademii Medycznej w Katowicach.
Kokot
F
F
Grzeszczak
W
W
Wocial
B
B
D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D016572:Cyclosporine / Q000008:administration & dosage; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006801:Humans; D007101:Immersion; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000601:surgery; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D011182:Postoperative Care; D011241:Prednisone / Q000008:administration & dosage; D011398:Promethazine / Q000008:administration & dosage; D012083:Renin / Q000097:blood*
D016572:Cyclosporine; D012083:Renin; D011398:Promethazine; D001379:Azathioprine; D011241:Prednisone; D009638:Norepinephrine; D004837:Epinephrine
Stezenie adrenaliny i noradrenaliny w osoczu krwi i aktywność reninowa osocza oraz ciśnienie tetnicze krwi u chorych z przeszczepiona nerka.