title: Neuropathologic and therapeutic studies in experimental spinal cord trauma.
abstract: Experimental spinal cord trauma was performed intraoperatively in 132 rabbits (Allen's method modified by Faden et al.). Only 77 animals were administered drugs (glucocorticoids, antioxidants and anti-inflammatory nonsteroids): Prednisolon, Fluocinolon-N-spray, Epurox, Ketazone, Rheopyrin and Rengasil. The remaining 55 animals were controls. Results were clinically (the assessment of lower limb movement was performed on a 5-score scale) and neuropathologically studied. From a clinical point of view, Prednisolon, Fluocinolon and Rengasil showed some beneficial effects. No significant differences of nervous fibre regeneration were noticed between probands and controls.
authors.affiliation: Institute of Neurology and Psychiatry, Bucharest, Romania.
authors.forename: N
authors.initials: N
authors.lastname: Anghelescu
authors.forename: A
authors.initials: A
authors.lastname: Petrescu
authors.forename: I
authors.initials: I
authors.lastname: Alexandrescu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D002374:Catalase / Q000627:therapeutic use; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D009416:Nerve Regeneration / Q000187:drug effects; D011817:Rabbits; D013116:Spinal Cord / Q000187:drug effects / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy / Q000473:pathology*; D013256:Steroids; D013482:Superoxide Dismutase / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D004338:Drug Combinations; D013256:Steroids; D002374:Catalase; D013482:Superoxide Dismutase; C050165:epurox