title: Administration or deprivation of nerve growth factor during development permanently alters neuronal geometry.
abstract: We investigated whether the administration or deprivation of a neuronal growth factor during development can permanently alter the dendritic architecture of sensitive neurons. Nerve growth factor (NGF) or NGF antiserum treatment in the first 2-3 postnatal weeks markedly affected the survival, size, and dendritic arborization of mouse sympathetic ganglion cells acutely. Six months after the completion of treatment, the number of surviving neurons, cell body size, and higher order dendritic branching had changed considerably from their values at 3 weeks, suggesting that these parameters remain malleable throughout postnatal life. However, the number of primary dendrites, a fundamental determinant of organization within sympathetic ganglia, was permanently altered by the neonatal treatment protocol. The idea emerging from this study is that NGF influences the elaboration of primary dendrites by sympathetic ganglion cells only during a critical developmental period. In maturity, NGF acts as a "maintenance" factor necessary for normal neuronal function and survival, but neurons lose the capacity to respond with wholesale rearrangements of dendritic architecture.
authors.affiliation: Department of Neurology and Neurological Surgery Neurology, Washington University School of Medicine, St. Louis, Missouri 63110.
authors.forename: K G
authors.initials: KG
authors.lastname: Ruit
authors.forename: W D
authors.initials: WD
authors.lastname: Snider
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005728:Ganglia, Sympathetic / Q000166:cytology* / Q000187:drug effects / Q000254:growth & development; D051379:Mice; D009414:Nerve Growth Factors / Q000008:administration & dosage* / Q000172:deficiency; D009474:Neurons / Q000166:cytology
chemical_list: D009414:Nerve Growth Factors