[The interaction of monoclonal antibodies to the structural proteins of the Vnukovo-32 vaccinal virus with other viruses of the rabies group].
The interaction of 7 monoclonal antibodies (MCA) to the nucleocapsid complex and 3 MCA to protein G of the vaccine virus Vnukovo-32 with 33 and 27 members of the rabies virus group, respectively, was studied. The indirect immunofluorescence test showed 7 MCA to the nucleocapsid complex to recognize 4 antigenic determinants (AD). Two MCA recognized the AD common for all the viruses under study. Individual ecological variants may be detected using other MCA. Three MCA to protein G had marked virus-neutralizing activity. MCA 1C5 neutralized all the rabies viruses under study. The other two MCA differed in the number of viruses they could neutralize. The viruses under study were divided into 4 groups depending on their interactions with certain MCA in neutralization test.
Gribencha
S V
SV
Vasilenko
O V
OV
Kuz'mitskaia
T M
TM
Furalev
V A
VA
Sveshnikov
P G
PG
Tatarov
A G
AG
Kolotvina
P V
PV
Barinskiĭ
I F
IF
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology* / Q000302:isolation & purification; D000937:Antigen-Antibody Reactions / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006825:Hybridomas / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009500:Neutralization Tests / Q000379:methods; D011819:Rabies Vaccines / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D012692:Serial Passage; D015678:Viral Structural Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D011819:Rabies Vaccines; D015678:Viral Structural Proteins
Vzaimodeĭstvie monoklonal'nykh antitel k strukturnym belkam vaktsinnogo virusa Vnukovo-32 s drugimi virusami gruppy beshenstva.