Studies on the ascorbic acid 2-sulfate biosynthesis in rat.
The possible biosynthesis of ascorbic acid 2-sulfate (AsS) in rat was investigated. A in vivo test was conducted according to Mumma and Mohamram. 10 mumoles ascorbic acid (AsA) and 25 mu Ci35SO4(2-) were injected intraperitoneally into rats once a day for four days. 24 hours after the final administration, the animals were sacrificed and the liver, kidneys and urine were collected. The result did not confirm the biosynthesis of AsS under the test conditions, though there appeared the possibility of the biosynthesis of a trace amount of AsS too small to permit detection.
Fukuda
T
T
Laboratory of Biological-organic chemistry, Joshi Eiyo University Sakado-shi, Saitama, Japan.
Komatsubara
H
H
Kasai
T
T
Tsujimura
M
M
D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000652:urine; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
C001956:ascorbic acid 2-sulfate; D001205:Ascorbic Acid