title: Hepatitis E virus genome. Molecular features, expression of immunoreactive proteins and sequence divergence.
abstract: The strategy for molecular cloning of hepatitis E virus (HEV), the major etiologic agent of enterically-transmitted non-A, non-B hepatitis, is briefly described. The organization of the HEV genome is discussed and compared to those of two other vertebrate viruses that contain single-stranded, positive-sense, polyadenylated RNA genomes with three overlapping ORFs. Serologic cross-reactivity of expressed proteins and genetic divergence of HEV isolates are also described within the context of sequence variation, type-common epitopes, and type-specific epitopes.
authors.affiliation: Centers for Disease Control, Atlanta, GA 30333.
authors.forename: D W
authors.initials: DW
authors.lastname: Bradley
authors.forename: M A
authors.initials: MA
authors.lastname: Purdy
authors.forename: G R
authors.initials: GR
authors.lastname: Reyes
mesh_terms: D003001:Cloning, Molecular; D014644:Genetic Variation; D016679:Genome, Viral; D016752:Hepatitis E virus / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D012367:RNA, Viral / Q000235:genetics
chemical_list: D012367:RNA, Viral