The stability of proton T2 effects of oxygen-17 water in experimental cerebral ischemia.
The gerbil model of unilateral cerebral ischemia has been used to test the temporal and spatial stability of the MRI T2 effects of oxygen-17 water. Following unilateral carotid ligation, symptomatic animals were given a single large intraperitoneal injection of H2(17)O and the distribution and stability of the brain T2 effects were followed with a spin-echo sequence. In contrast to the ischemic areas, the perfused tissue shows a marked and prolonged loss in intensity with little evidence of diffusion of the T2 effect of 17O into the ischemic tissue.
Hopkins
A L
AL
Department of Anatomy, Case Western Reserve University, Cleveland, Ohio.
Lust
W D
WD
Haacke
E M
EM
Wielopolski
P
P
Barr
R G
RG
Bratton
C B
CB
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D005849:Gerbillinae; D007274:Injections, Intraperitoneal; D008279:Magnetic Resonance Imaging; D008297:Male; D010104:Oxygen Radioisotopes; D014867:Water / Q000008:administration & dosage / Q000378:metabolism*
D010104:Oxygen Radioisotopes; D014867:Water