title: The molecular basis for tropomyosin isoform diversity.
abstract: The tropomyosins are a family of actin filament binding proteins. In multicellular animals, they exhibit extensive cell type specific isoform diversity. In this essay we discuss the genetic mechanisms by which this diversity is generated and its possible significance to cellular function.
authors.affiliation: Cold Spring Harbor Laboratory, New York, NY 11724.
authors.forename: J P
authors.initials: JP
authors.lastname: Lees-Miller
authors.forename: D M
authors.initials: DM
authors.lastname: Helfman
mesh_terms: D000595:Amino Acid Sequence; D000828:Animal Population Groups / Q000235:genetics; D000818:Animals; D001923:Brain Chemistry; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism; D005658:Fungi / Q000235:genetics; D005786:Gene Expression Regulation; D005796:Genes; D005800:Genes, Fungal; D008969:Molecular Sequence Data; D005810:Multigene Family; D009124:Muscle Proteins / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis; D009928:Organ Specificity; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014335:Tropomyosin / Q000145:classification / Q000235:genetics*
chemical_list: D009124:Muscle Proteins; D009419:Nerve Tissue Proteins; D014335:Tropomyosin