title: Protective effect of oral selenium plus copper associated with vitamin complex on sunburn cell formation in human skin.
abstract: An organic form of selenium (plus copper) and a vitamin complex (with tocopherol and retinol) were examined for their ability to prevent sunburn cell formation in human skin exposed to ultraviolet radiation from a xenon solar simulator. After three weeks of supplementation with selenium, especially in association with vitamins, there was a relative protection (versus placebo) against ultraviolet-induced cell damage in the suberythemal range but not in the supraerythemal area. Antioxidant properties of the compounds can explain such cellular photoprotective effect. Supplementation was ineffective in preventing light-induced erythema.
authors.affiliation: Laboratoires Gresval, Foundation A. de Rothschild, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: la Ruche
authors.forename: J P
authors.initials: JP
authors.lastname: Césarini
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003300:Copper / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000008:administration & dosage*; D012867:Skin / Q000473:pathology*; D013471:Sunburn / Q000473:pathology / Q000517:prevention & control*; D014801:Vitamin A / Q000008:administration & dosage; D014810:Vitamin E / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014815:Vitamins; D014801:Vitamin A; D014810:Vitamin E; D003300:Copper; D012643:Selenium