Serum F-protein concentration following halothane or isoflurane anaesthesia.
We have investigated the prevalence of hepatic injury following uncomplicated anaesthesia using a sensitive and specific marker of hepatic damage, the serum F-protein concentration. The median variation in serum F-protein in fit adults over six days is 16 ng/ml, minimum 0 ng/ml, maximum 36 ng/ml. A significant rise in serum F-protein was demonstrated six days following anaesthesia and surgery, but not earlier after 3 or 24 h. There was no significant difference between patients who received halothane (n = 12) or isoflurane (n = 13). These changes were not related to duration of anaesthesia, quantity of delivered volatile agent or mode of ventilation. Hepatocellular damage may occur following anaesthesia for minor surgery.
Cooper
C M
CM
Department of Anaesthetics, Medical School, Royal Hallamshire Hospital, Sheffield, UK.
Foster
G R
GR
Cooper
A E
AE
Kenny
M
M
Olivera
D B
DB
D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006221:Halothane; D006801:Humans; D007519:Isoantigens / Q000032:analysis / Q000378:metabolism*; D007530:Isoflurane; D008099:Liver / Q000473:pathology*; D008297:Male
D015415:Biomarkers; D007519:Isoantigens; C030497:liver specific F antigen; D007530:Isoflurane; D006221:Halothane