title: [Anticoagulants of the nondialyzed fractions of the ammonia extract of the herb Pulmonaria mollissima].
abstract: T-100 anticoagulants non-dialyzed through cellophane are isolated from ammonia extract of herb Pulmonaria mollissima. Their effect is mainly realized at the stage of coagulation conversions of fibrinogen, first of all at the stage of fibrin self-assembly. One of these anticoagulants is a peptide, another one is a glycopeptide which contains glucose residues like carbohydrate. Peptide components of the both anticoagulants are characterized by the high level of amino acids, their radicals are capable to ionization under physiological conditions. In contrast to animal-origin analogs, glycopeptide in nontoxic doses causes stable hypocoagulemia in animals. It is expedient to study Pulmonaria mollissima extracts as a source of direct anticoagulants.
authors.forename: A Sh
authors.initials: ASh
authors.lastname: Byshevskiĭ
authors.forename: I A
authors.initials: IA
authors.lastname: Dement'eva
authors.forename: P I
authors.initials: PI
authors.lastname: Leven
authors.forename: O P
authors.initials: OP
authors.lastname: Leonova
authors.forename: M K
authors.initials: MK
authors.lastname: Chabanov
authors.forename: E A
authors.initials: EA
authors.lastname: Chiriat'eva
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000641:Ammonia; D000818:Animals; D000925:Anticoagulants / Q000302:isolation & purification* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D003956:Dialysis; D005337:Fibrin / Q000096:biosynthesis; D005340:Fibrinogen / Q000378:metabolism; D005609:Free Radicals; D008970:Molecular Weight; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D000596:Amino Acids; D000925:Anticoagulants; D005609:Free Radicals; D010455:Peptides; D010936:Plant Extracts; D000641:Ammonia; D005337:Fibrin; D005340:Fibrinogen
vernacular_title: Antikoagulianty nedializuiushcheĭ fraktsii ammiachnogo ékstrakta travy medunitsy miagchaĭsheĭ.