title: Haemagglutination-inhibiting antibodies against influenza A and B in human sera collected from five ecological zones in Nigeria.
abstract: The prevalence of antibodies to the haemagglutinins of two influenza A subtype, H1N1 and H3N2 and influenza B in sera collected from 1986 to 1988 from persons of different ages and from 10 locations in 5 ecological zones of Nigeria was determined. The levels of influenza antibodies in the sera varies with age and ecological zones of the country. A total of 1,022 sera were tested, of which 732 (71.6%) were positive for influenza antibodies. The prevalence of antibodies at titre 1:10 varied between 31.1% in the derived savannah and 94.4% in the swamp forest. The prevalence in the other zones were: rain forest 63.9%, guinea savannah 86.0% and 78.0% in sudan savannah. Reactors with the two influenza A subtypes antigens were more than reactors with influenza B antigens in the country. Antibody levels to influenza A subtypes varied between and within zones. Although there was no significant difference a (P greater than 0.05) in the overall prevalence of antibodies to the two subtypes, more sera had haemagglutination-inhibiting antibody to H1N1 subtype than H3N2 subtype in all the zones except in the rain forest. Prevalence of antibodies to influenza viruses increased with age in all the zones. Overcrowding in big cities and dry, dusty harmattan weather of the northern parts of the country are considered as possible risk factors in the epidemiology of influenza in Nigeria.
authors.affiliation: Department of Virology, College of Medicine, University of Ibadan, Nigeria.
authors.forename: D O
authors.initials: DO
authors.lastname: Olaleye
authors.forename: S S
authors.initials: SS
authors.lastname: Baba
authors.forename: S A
authors.initials: SA
authors.lastname: Omilabu
authors.forename: A H
authors.initials: AH
authors.lastname: Fagbami
mesh_terms: D000914:Antibodies, Viral / Q000302:isolation & purification*; D004463:Ecology; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D009549:Nigeria
chemical_list: D000914:Antibodies, Viral