[Variability of the response to recombinant human erythropoietin in patients undergoing hemodialysis treatment].
The paper assesses the existence of possible interference between dialysis and the response to human recombinant erythropoietin administered i.v. in a group of patients undergoing regular dialysis. The results obtained show that the time taken to reach the set hemoglobin target (Hb 10 g%) was shorter in hemodiafiltered (HDF) patients compared to those receiving bicarbonate dialysis (BD). A plausible explantation may be the different depurative characteristics and the greater degree of biocompatibility of alternative dialysis which is able to achieve a more rapid cellular response to pharmacological stimulation.
Baroni
A
A
Divisione Nefrologia, Ospedale SS. Trinità, Borgomanero, Novara.
Airoldi
G
G
Agliata
S
S
Fortina
F
F
Ragazzoni
E
E
Cavagnino
A
A
De Nigris
A
A
Cametti
G
G
Ferrero
D
D
Fortina
A
A
D000328:Adult; D000368:Aged; D000740:Anemia / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D001853:Bone Marrow / Q000473:pathology; D015672:Erythroid Precursor Cells / Q000473:pathology; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006440:Hemofiltration; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D006435:Renal Dialysis
D007155:Immunologic Factors; D011993:Recombinant Fusion Proteins; D004921:Erythropoietin
Variabilità di risposta all'eritropoietina umana ricombinante nei pazienti in trattamento emodialitico.