Effect of tuftsin and its partial sequences on the arterial blood pressure in guinea-pigs.
The effect of tuftsin (Thr-Lys-Pro-Arg) and its partial sequences: Thr-Lys-Pro, Lys-Pro-Arg, Thr-Lys, Lys-Pro and Pro-Arg on arterial blood pressure was studied in experiments on guinea-pigs anesthetized with urethane. The peptides were administered intravenously in a dose of 1 mg/kg. The blood pressure was measured directly in the carotid artery. Tuftsin and peptides: Thr-Lys-Pro, Thr-Lys and Pro-Arg, after longer period of latency, caused protracted rise in arterial blood pressure. Such action was not shown by Lys-Pro-Arg and Lys-Pro.
Paradowski
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A
Department of Physiology, Pomeranian Medical Academy, Szczecin.
Dynowski
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Z
Kubik
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A
Siemion
I Z
IZ
D000595:Amino Acid Sequence; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002339:Carotid Arteries; D006168:Guinea Pigs; D007275:Injections, Intravenous; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014405:Tuftsin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
D010446:Peptide Fragments; D014405:Tuftsin