[Comparison of the inhibitory effects of a psychostimulant of the sydnonimine series on the development of stress and ethanol induced lesions in the rat gastric mucosa].
The possibility of the inhibitory influence of one of the psychostimulators of sydnonimine derivatives OF 743 on stress--and ethanol-induced mucosal lesions was studied in rats. Large doses (15 mg/kg) OF 743, which induced both central, psychostimulator, peripheral, and vagolytic effects equally decrease stress- and ethanol-induced mucosal lesions. The smaller doses, which show only peripheral effects, largely inhibit ethanol-induced lesions. The degree of the inhibitory influence of OF 743 is comparable with the same atropine influence and considerably exceeds the degree of the inhibitory influence of pirenzepine.
Natsvlishvili
N A
NA
Samonina
G E
GE
Ashmarin
I P
IP
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D003080:Cold Temperature; D000431:Ethanol / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D007103:Immobilization; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D010890:Pirenzepine / Q000494:pharmacology; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000473:pathology*; D013558:Sydnones / Q000494:pharmacology*
D000928:Antidepressive Agents; D010276:Parasympatholytics; D013558:Sydnones; C072808:OF 743; C013271:sydnophen; D010890:Pirenzepine; D000431:Ethanol; D001285:Atropine
Sopostavlenie tormoziashchego deĭstviia psikhostimuliatora sidnoniminovogo riada na razvitie stressornykh i étanolovykh povrezhdeniĭ slizistoĭ obolochki zheludka u krys.