Removal of 5-hydroxytryptamine by rat lungs.
Isolated rat lungs perfused with Krebs solution removed free radioactive 5-Hydroxytryptamine (5 HT or serotonin) from the fluid perfusing them. However, when platelets labelled with 111In-oxine to tag them individually, and with 14C-labelled 5 HT were also perfused via the lungs, there was no significant removal of the labelled 5 HT from the platelets. Paper chromatography showed that 46.7% of the platelet bound 5 HT was metabolished to an unidentified material. Rat lungs remove free 5 HT from plasma but not when it is platelet bound.
Osim
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EE
Surgical Unit, Faculty of Clinical Sciences, University College London, United Kingdom.
Wyllie
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JH
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D002250:Carbon Radioisotopes; D002854:Chromatography, Paper; D007205:Indium Radioisotopes; D008168:Lung / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D002250:Carbon Radioisotopes; D007205:Indium Radioisotopes; D012701:Serotonin