title: Immunological upgrading with combined immunotherapy and chemotherapy in a lepromatous leprosy patient: a case report.
abstract: Immunotherapy with Mycobacterium w was given, in addition to standard multidrug therapy (MDT) to a lepromatous leprosy (LL) patient with a bacteriological index (BI) of 6. After 15 months of treatment this patient attained bacteriological negativity and clinical inactivity. Histopathologically the patient upgraded to borderline-tuberculoid at 12 months, and at 15 months showed features of nonspecific infiltration in the dermis. The rapid immunological upgrading seen in the patient is highlighted in this paper.
authors.affiliation: National Institute of Immunology, New Delhi, India.
authors.forename: S A
authors.initials: SA
authors.lastname: Zaheer
authors.forename: N R
authors.initials: NR
authors.lastname: Suresh
authors.forename: H K
authors.initials: HK
authors.lastname: Kar
authors.forename: A K
authors.initials: AK
authors.lastname: Sharma
authors.forename: A
authors.initials: A
authors.lastname: Mukherjee
authors.forename: R
authors.initials: R
authors.lastname: Mukherjee
authors.forename: G P
authors.initials: GP
authors.lastname: Talwar
mesh_terms: D001428:Bacterial Vaccines / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D006801:Humans; D007916:Lepromin / Q000276:immunology; D007917:Leprostatic Agents / Q000008:administration & dosage*; D015440:Leprosy, Lepromatous / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D007917:Leprostatic Agents; C060596:anti-leprosy vaccine; D007916:Lepromin