title: [The search for new antiparasitic agents. 9. The anthelmintic activity of halogen-containing sulfonamidobenzamides].
abstract: The results of preclinical trials of 28 new compounds of haloid-containing sulfamidobenzamides with low toxicity are presented. The trials on a hymenolepiasis model showed that effectiveness of N-(2,5-dichlorophenyl)-2/(3-nitro-4-chlorophenyl) sulfonylamino/-5-bromobenzamide was similar to that of the well-known drug niclosamide. In the trials on an opisthorchiasis model, 2 compounds were shown to be highly effective, and on a trichocephaliasis model 5 compounds showed a high activity.
authors.forename: F S
authors.initials: FS
authors.lastname: Mikhaĭlitsyn
authors.forename: M N
authors.initials: MN
authors.lastname: Lebedeva
authors.forename: D G
authors.initials: DG
authors.lastname: Baiandina
authors.forename: N P
authors.initials: NP
authors.lastname: Kozyreva
authors.forename: N D
authors.initials: ND
authors.lastname: Lychko
authors.forename: L A
authors.initials: LA
authors.lastname: Bolotina
authors.forename: S K
authors.initials: SK
authors.lastname: Drusviatskaia
authors.forename: A S
authors.initials: AS
authors.lastname: Naĭdenova
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006219:Halogens / Q000627:therapeutic use; D006373:Helminthiasis / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D000871:Anthelmintics; D001549:Benzamides; D006219:Halogens; D013449:Sulfonamides
vernacular_title: Izyskanie novykh protivoparazitarnykh sredstv. 9. Protivogel'mintnaia aktivnost' galoidsoderzhashchikh sul'fonamidobenzamidov.