Sulfated polyanions do not inhibit duck hepatitis B virus infection.
On the basis of the antiviral action of sulfated polyanions in human immunodeficiency virus and other viral infections, we studied the effect of dextran sulfate and heparin on duck hepatitis B virus infection. These agents do not affect viral uptake and replication in liver cells in vitro or in vivo. Sulfated polyanions, therefore, appear to have no potential for the treatment of hepadnavirus infections.
Offensperger
W B
WB
Department of Medicine, University of Freiburg, Germany.
Offensperger
S
S
Walter
E
E
Blum
H E
HE
Gerok
W
W
D000818:Animals; D002478:Cells, Cultured; D002738:Chloroquine / Q000494:pharmacology; D016264:Dextran Sulfate / Q000627:therapeutic use*; D004372:Ducks; D006493:Heparin / Q000627:therapeutic use*; D015611:Hepatitis B Virus, Duck / Q000187:drug effects*; D006524:Hepatitis, Viral, Animal / Q000382:microbiology / Q000517:prevention & control*; D008099:Liver / Q000166:cytology / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects
D002738:Chloroquine; D006493:Heparin; D016264:Dextran Sulfate