Pharmacokinetics of intramuscular nicomorphine and its metabolites in man.
After i.m. injection nicomorphine is relatively slowly absorbed from the muscular depot and is found in the serum for approximately 1 h. The rate of absorption differs between patients and governs the overall pharmacokinetic profile of the compound. The relative AUCs were nicomorphine 18%, 6-nicotinoylmorphine 17%, and morphine 65%. Nicomorphine and 6-nicotinoylmorphine have significantly higher AUCs after i.m. injection than after i.v. injection, while the AUC of morphine and the total AUC show no difference between the two modes of administration.
Koopman-Kimenai
P M
PM
Department of Clinical Pharmacy, Academic Hospital Nijmegen Sint Radboud, The Netherlands.
Vree
T B
TB
Booij
L H
LH
Dirksen
R
R
Nijhuis
G M
GM
D000328:Adult; D005260:Female; D006207:Half-Life; D006801:Humans; D007273:Injections, Intramuscular; D008875:Middle Aged; D009020:Morphine / Q000097:blood / Q000493:pharmacokinetics; D009022:Morphine Derivatives / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics; D011292:Premedication; D013997:Time Factors
D009022:Morphine Derivatives; D009539:Nicotinic Acids; C032054:morphine 6-nicotinate; D009020:Morphine; C008549:nicomorphine