Nickel chloride: potential accumulation from the airway. Toxicokinetics in rats.
The rate removal of nickel from the airway was measured in vivo. Removal in vivo was studied by intratracheal injection of nickel chloride solutions. Regardless of time after injection, the lungs and heart retained the greatest concentration of nickel and 40 days after 1.68 mumol administration they were the organs where nickel was still significantly measurable. The slow removal of nickel may indicate the presence of high affinity binding sites in the lung. Nickel can interact with others metals, such as copper and zinc, so that nickel exposure may have public health implications.
Novelli
E B
EB
Department of Chemistry, Universidade Estadual Paulista, UNESP, Botucatu, São Paulo, Brasil.
Rodrigues
N L
NL
D000818:Animals; D003300:Copper / Q000378:metabolism; D007267:Injections; D008168:Lung / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D009206:Myocardium / Q000737:chemistry; D009532:Nickel / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014132:Trachea; D015032:Zinc / Q000378:metabolism
C022838:nickel chloride; D003300:Copper; D009532:Nickel; D015032:Zinc