[Kinetics and distribution of transplanted sarcoma JWS and leukemia L1210 cells by intravenous route].
The aim of this work was to compare the distribution in organs of syngeneic mice sarcoma JWS and leukemia L-1210 cells previously labelled with sodium dichromate (Na2 51CrO4) and iododeoxyuridine (125IUDR) after i.v. transplantation. Also, the results obtained with both labels were compared. Both kinds of cells under study are trapped in lungs, but the number of trapped JWS cells is greater. L-1210 cells probably recirculate. The cells undergo extensive destruction during the first 3 days after transplantation. This kind of study requires the use of two markers: cytoplasmic and nuclear and careful analysis of radioactivity changes is also required to obtain proper conclusions.
Skierska
E
E
Zakład Biologii Akademii Wychowania Fizycznego, Warszawie.
Skierski
J S
JS
D000818:Animals; D002860:Chromium Radioisotopes; D007939:Leukemia L1210 / Q000473:pathology*; D008099:Liver / Q000098:blood supply / Q000473:pathology*; D008168:Lung / Q000098:blood supply / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation / Q000473:pathology; D009360:Neoplastic Cells, Circulating / Q000473:pathology* / Q000528:radiation effects; D012513:Sarcoma, Experimental / Q000473:pathology*; D013154:Spleen / Q000098:blood supply / Q000473:pathology*; D014680:Veins
D002860:Chromium Radioisotopes
Kinetyka i rozmieszczenie dozylnie transplantowanych komórek nowotworowych miesaka JWS i białaczki limfatycznej L-1210.