[Implications of 5-HT2 receptors in the increase of slow wave sleep in healthy volunteers under amoxapine].
Amoxapine is an antidepressant drug which increases stages III and IV of slow wave sleep to both bad sleepers and volunteers. This effect appears within several studies during the whole period of amoxapine administration (3 or 4 weeks). On the other hand, specific 5-HT2 antagonists produce the same effect upon the slow wave sleep, to both bad sleepers and volunteers. Biological studies showed that amoxapine is the strongest 5-HT2 inhibitor among antidepressant drugs. Therefore amoxapine effect upon slow wave sleep would be relied to 5-HT2 receptor blocking. The author reviews some hypothesis related to slow wave sleep regulation by serotonin.
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Service Hospitalo-Universitaire de Psychiatrie, CHS Pinel, Dury, Amiens.
D000657:Amoxapine / Q000494:pharmacology*; D004341:Drug Evaluation; D006801:Humans; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D016713:Ritanserin / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects / Q000502:physiology*
D011985:Receptors, Serotonin; D016713:Ritanserin; D000657:Amoxapine
Implications des récepteurs 5-HT2 dans l'augmentation du sommeil lent profond chez le volontaire sain sous amoxapine.