title: Direct enantiomeric separation of terfenadine and its major acid metabolite by high-performance liquid chromatography, and the lack of stereoselective terfenadine enantiomer biotransformation in man.
abstract: Direct enantiomeric separation of terfenadine and its major acid metabolite was achieved by using two different chiral stationary phase columns with two different mobile phase systems. Further, the enantiomeric composition of the human urinary acid metabolite has been determined, indicating a non-stereoselective biotransformation in man.
authors.affiliation: Marion Merrell Dow Inc., Cincinnati, OH 45215-6300.
authors.forename: K Y
authors.initials: KY
authors.lastname: Chan
authors.forename: R C
authors.initials: RC
authors.lastname: George
authors.forename: T M
authors.initials: TM
authors.lastname: Chen
authors.forename: R A
authors.initials: RA
authors.lastname: Okerholm
mesh_terms: D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D008297:Male; D013237:Stereoisomerism; D016593:Terfenadine / Q000493:pharmacokinetics* / Q000652:urine*
chemical_list: D016593:Terfenadine