title: Chemoprophylaxis of meningitis.
abstract: Chemoprophylaxis of meningitis caused by Neisseria meningitidis and Haemophilus influenzae may be determined by the epidemiology of transmission, the antibiotic susceptibility patterns of the organisms, and the usage of vaccines. A review of transmission in England distinguishes differences in sporadic and cluster meningococcal infections. Because of resistance to sulphadiazine, rifampicin and ciprofloxacin are prophylactic agents of choice. Vaccination can be a useful adjunct to antibiotic prophylaxis. Prophylaxis for meningitis due to H. influenzae type b can be provided by rifampicin and vaccination can also be an adjunct to antibiotic prophylaxis.
authors.affiliation: Manchester Public Health Laboratory, Withington Hospital, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Jones
mesh_terms: D002939:Ciprofloxacin / Q000627:therapeutic use; D006801:Humans; D008583:Meningitis, Haemophilus / Q000517:prevention & control*; D008585:Meningitis, Meningococcal / Q000517:prevention & control*; D012293:Rifampin / Q000627:therapeutic use; D014611:Vaccination
chemical_list: D002939:Ciprofloxacin; D012293:Rifampin