[Development and pharmacokinetic study of miocamycin sustained-release tablet remaining--floating in stomach].
A novel sustained-release tablet of miocamycin was developed based on the hydrodynamically balanced controlled drug delivery system (HBS). It was prepared to contain fast-release and sustained-release granules. The gamma-scintiphotographic study after oral ingestion showed that MOM-HBS remained in human stomach for more than 7 hours, much longer than the conventional tablet (3-4 h). The in vitro release characteristics showed basically first-order kinetics (Kr = 0.1619 h-1). The serum concentration-time course of MOM-HBS exhibited typical sustained-release characteristics. Moreover, The percentage of drug released in vitro versus the percentage of drug released in vivo of MOM-HBS indicated excellent linearity. Its relative bioavailability was increased greatly compared with MOM dry syrup produced in Japan.
Diao
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Department of Pharmaceutics, China Pharmaceutical University, Nanjing.
Tu
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XD
D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D015644:Miocamycin / Q000493:pharmacokinetics*; D013607:Tablets
D003692:Delayed-Action Preparations; D013607:Tablets; D015644:Miocamycin