title: Anthelmintic activity of some 3-substituted phenyl-1-alkyl or phenyl propenones and propenamides.
abstract: In a search for new anthelmintic compounds, a,beta-unsaturated ketones and amides were synthetized. Their anthelmintic activity was tested against two gastrointestinal worms, a nematode Syphacia obvelata and a cestode Hymenolepis nana. Structure-activity relationships are discussed.
authors.affiliation: Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Lyon, France.
authors.forename: N
authors.initials: N
authors.lastname: Walchshofer
authors.forename: M
authors.initials: M
authors.lastname: Minjat
authors.forename: A F
authors.initials: AF
authors.lastname: Petavy
authors.forename: J
authors.initials: J
authors.lastname: Paris
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology; D002934:Cinnamates / Q000138:chemical synthesis* / Q000494:pharmacology; D006925:Hymenolepiasis / Q000188:drug therapy / Q000523:psychology; D006926:Hymenolepis / Q000187:drug effects; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D010123:Oxyuriasis / Q000188:drug therapy / Q000469:parasitology; D010124:Oxyuroidea / Q000187:drug effects; D011427:Propiophenones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000871:Anthelmintics; D002934:Cinnamates; D007659:Ketones; D011427:Propiophenones