title: Supersensitivity to isoprenaline induced in cultured neonatal rat heart cells by certain eicosatetraenoic acids.
abstract: Among a number of racemic eicosatetraenoic acids (HETEs) investigated, 15-R/S HETE and 11-R/S-HETE were the only ones that enormously potentiated the chronotropic action of isoprenaline on neonatal rat heart myocytes in rocked culture. The effect of the 15-R/S-HETE was exclusively due to the S isomer.
authors.affiliation: Institut für Herz-Kreislauf-Forschung, Berlin-Buch, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Wallukat
authors.forename: H
authors.initials: H
authors.lastname: Kuehn
authors.forename: A
authors.initials: A
authors.lastname: Wollenberger
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001095:Arachidonic Acids / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001095:Arachidonic Acids; D007545:Isoproterenol