title: Quantitative measurement of regional cerebral blood flow with I-123 IMP SPECT: a correction of the microsphere model by global extraction between artery and internal jugular vein.
abstract: Quantitative measurements of regional cerebral blood flow with N-isopropyl-(Iodine 123)p-iodoamphetamine (I-123 IMP) as a microsphere model were performed in forty cases. The regional cerebral blood flow values obtained with I-123 IMP were slightly underestimated compared with those of Xe-133 inhalation methods (y = 0.90x-2.1, r = 0.85, p less than 0.01). After correction by global extraction (87%) between the artery and internal jugular vein, which was measured in four patients by means of a catheter technique, the underestimation of the values obtained with I-123 IMP was improved (y = 1.0x-2.4, r = 0.85, p less than 0.01). Several problems in the accurate quantitative measurement of regional cerebral blood flow with I-123 IMP are discussed.
authors.affiliation: Department of Radiology, Fujita Health University School of Medicine, Aichi, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Takeshita
authors.forename: H
authors.initials: H
authors.lastname: Toyama
authors.forename: K
authors.initials: K
authors.lastname: Nakane
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Katada
authors.forename: A
authors.initials: A
authors.lastname: Takeuchi
authors.forename: S
authors.initials: S
authors.lastname: Koga
mesh_terms: D000328:Adult; D000368:Aged; D000662:Amphetamines; D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D008954:Models, Biological; D012016:Reference Values; D015899:Tomography, Emission-Computed, Single-Photon; D014980:Xenon Radioisotopes
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D014980:Xenon Radioisotopes; D020367:Iofetamine