[Immunosuppressor activity of B-cells in patients with chronic lymphocytic leukemia. Their possible role in the pathogenesis of the disease].
The data presented indicate that B cells from patients with chronic lymphocytic leukemia (CLL) may produce suppressive factors capable of inhibiting T and B cell proliferation and Ig secretion. Two factors with the molecular weight 65-75 KDa (SBF1) and 15-25 KDa (SBF2) have been characterized. SBFs are primarily produced by B cells with a low flow density. There is a reverse dependence between the capacity of leukemic B cells for spontaneous Ig secretion and their ability for the production of suppressive factors. The autocrine and paracrine pathways of B cell regulation in the pathogenesis of chronic lymphocytic leukemia are discussed.
Chernykh
E R
ER
Tikhonova
M A
MA
Ostanin
A A
AA
Shevela
E Ia
EIa
Blazhievich
I A
IA
Shubinskiĭ
G Z
GZ
D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002452:Cell Count; D002455:Cell Division / Q000502:physiology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D066298:In Vitro Techniques; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000209:etiology / Q000276:immunology*; D008214:Lymphocytes / Q000473:pathology; D008222:Lymphokines / Q000096:biosynthesis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008222:Lymphokines; C048134:suppressive B cell factor
Immunosupressornaia aktivnost' B-kletok bol'nykh khronicheskim limfoleĭkozom. Vozmozhnaia rol' v patogeneze zabolevaniia.