[Protective effect of hepatic stimulator substance against experimental acute liver failure in mice].
A hepatic stimulator substance (HSS) was extracted from the liver of male weanling SD rats according to the method of LaBrecque. The mice were injected with carbon tetrachloride or D-galactosamine to induce hepatic injuries and the protective effect of HSS on thus induced hepatic damage was investigated. The results were as follows: (1) HSS could suppresses the elevation of sGPT and sGOT induced by carbon tetrachloride intoxication in a dose-dependent manner. (2) Hepatic histological findings indicated that the degree of CCl4 or D-galactosamine-induced hepatic lesions could be lessened by HSS. (3) CCl4-induced reduction of hepatic mitochondrial succinic dehydrogenase activity could be restored by HSS. (4) Insulin-glucagon enhanced the survival of D-galactosamine intoxicated mice and stimulated hepatocyte proliferation, thus showing less pronounced hepatic damage.
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Department of Physiology, Dalian Medical College.
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D051700:Activating Transcription Factor 3; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology / Q000517:prevention & control; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004268:DNA-Binding Proteins / Q000627:therapeutic use*; D005688:Galactosamine; D005934:Glucagon / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D016350:Leucine Zippers; D008115:Liver Regeneration; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism
D051700:Activating Transcription Factor 3; D004268:DNA-Binding Proteins; D007328:Insulin; C068616:liver regeneration factor 1; D005688:Galactosamine; D005934:Glucagon; D013385:Succinate Dehydrogenase