Non-identical newborn twins with congenital adrenal hyperplasia.
Two neonates, one female and one male, with congenital adrenal hyperplasia due to 21-hydroxylase deficiency are described. The inheritance of this disease is autosomal recessive. It is of interest that these two babies were non-identical twins. 21-hydroxylase deficiency is briefly discussed and some relevant aspects of the hormonal control of the development of morphological or phenotypic sex are presented. Some of the difficulties encountered following the diagnosis of this condition in Papua New Guinea are mentioned.
Brian
M J
MJ
Goroka Base Hospital, Papua New Guinea.
D000312:Adrenal Hyperplasia, Congenital / Q000208:ethnology / Q000473:pathology*; D004200:Diseases in Twins / Q000175:diagnosis* / Q000208:ethnology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010219:Papua New Guinea; D014429:Twins, Dizygotic