title: Development of resistance to quinolones in five patients with campylobacteriosis treated with norfloxacin or ciprofloxacin.
abstract: Development of resistance to nalidixic acid, norfloxacin and ciprofloxacin was observed in five patients with Campylobacter jejuni or Campylobacter coli infection. From all these patients nalidixic acid- and quinolone-susceptible strains were isolated initially, whereas after therapy with norfloxacin or ciprofloxacin strains resistant to these antibiotics were found. Campylobacter strains from the same patient always belonged to the same species and, with the exception of one case, showed identical rRNA gene restriction (rDNA) patterns. This indicates that double-infection with a susceptible and a resistant strain was not responsible for the phenomenon but rather that the infecting strain rapidly developed resistance following treatment.
authors.affiliation: Department of Medical Microbiology, University of Zurich, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Adler-Mosca
authors.forename: J
authors.initials: J
authors.lastname: Lüthy-Hottenstein
authors.forename: G
authors.initials: G
authors.lastname: Martinetti Lucchini
authors.forename: A
authors.initials: A
authors.lastname: Burnens
authors.forename: M
authors.initials: M
authors.lastname: Altwegg
mesh_terms: D000328:Adult; D002169:Campylobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D017000:Campylobacter coli / Q000187:drug effects* / Q000302:isolation & purification; D016123:Campylobacter jejuni / Q000187:drug effects* / Q000302:isolation & purification; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004269:DNA, Bacterial / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D009268:Nalidixic Acid / Q000627:therapeutic use; D009643:Norfloxacin / Q000627:therapeutic use*; D015183:Restriction Mapping
chemical_list: D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D009268:Nalidixic Acid; D002939:Ciprofloxacin; D009643:Norfloxacin