title: [Chronic active hepatitis and possible relationship with immunosuppressive therapy].
abstract: A 54-year-old man with Chagas cardiomyopathy that was submitted to a heart transplantation and five months later presented a progressive increase in liver enzymes. Diagnosis of chronic active hepatitis was confirmed by histopathologic studies. A transitory interruption of treatment with azathioprine and the posterior re-introduction of small doses, as well as the use of lesser amounts of cyclosporin-A improved the clinical and laboratory pictures. Despite several investigations the pathogenesis of hepatitis remained undetermined, although some type of drug injury was presumed to be involved. The eventual role of viruses as the primary inciting event could not be completely ruled out.
authors.affiliation: Hospital São Joaquim da Real e Benemérita, Sociedade Portuguesa de Beneficência de São Paulo, Capital.
authors.forename: V B
authors.initials: VB
authors.lastname: de Carvalho
authors.forename: F A
authors.initials: FA
authors.lastname: Fonseca
authors.forename: A
authors.initials: A
authors.lastname: de Oliveira e Silva
authors.forename: F R
authors.initials: FR
authors.lastname: Molina
authors.forename: G C
authors.initials: GC
authors.lastname: Santo
authors.forename: T E
authors.initials: TE
authors.lastname: dos Santos
authors.forename: E F
authors.initials: EF
authors.lastname: de Souza
authors.forename: R
authors.initials: R
authors.lastname: Macruz
authors.forename: E de J
authors.initials: Ede J
authors.lastname: Zerbini
mesh_terms: D002598:Chagas Cardiomyopathy / Q000601:surgery*; D056487:Chemical and Drug Induced Liver Injury, Chronic; D006334:Heart Function Tests; D016027:Heart Transplantation; D006521:Hepatitis, Chronic / Q000201:enzymology; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents
vernacular_title: Hepatite crônica ativa e possível relação com terapia imunossupressora.