Insulin-like growth factor I (IGF-I) and growth in children undergoing hemodialysis or after successful renal transplantation.
To analyze the relationship between IGF-I and growth in children with chronic renal failure, we studied 7 patients undergoing hemodialysis and 7 patients after successful renal transplantation. IGF-I was measured by acid chromatography using ODS silica columns. Hemodialyzed patients grew poorly (mean 1.5 cm/y), and although transplanted patients did significantly better (mean 3.3 cm/y), 4 out of 7 did not reach normal height velocity. IGF-I levels in transplanted patients (39.2 +/- 13.6 nM/l) were significantly higher than in hemodialyzed patients (13.4 +/- 3.0 before; 17.0 +/- 5.4, after dialysis, nM/l). Nevertheless, all individual values in both groups fell within normal limits. The mean logarithmic deviation of IGF-I values of hemodialyzed patients was not significantly different from normal. The logarithmic deviation of transplanted patients was significantly higher than normal, indicating a true, albeit slight, increase in the levels of this growth factor No significant correlation was found between IGF-I and growth velocity. Serum IGF-I levels in these children do not help to explain their growth failure.
Jasper
H G
HG
Centro de Investigaciones Endocrinológicas (CEDIE), Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.
Ferraris
J R
JR
D000293:Adolescent; D002648:Child; D002845:Chromatography; D006128:Growth; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D016030:Kidney Transplantation; D006435:Renal Dialysis
D007334:Insulin-Like Growth Factor I