title: Cytotoxic activity of Amaryllidaceae alkaloids from Crinum augustum and Crinum bulbispermum.
abstract: The cytotoxic activity of five minor Amaryllidaceae alkaloids and one flavan isolated from Crinum augustum Rox and Crinum bulbispermum Milne were tested on human leukemic Molt 4 cells. Whereas the crinine-type alkaloids (6 alpha-hydroxycrinine, powelline) and the new type augustamine did not even inhibit the growth of Molt 4 cells, the lycorine-type alkaloid (pratorinine) and the crinine-type alkaloid (6 alpha-hydroxybuphanisine) showed a moderate cytotoxic activity and the flavan (4'-hydroxy-7-methoxyflavan) showed an important cytotoxic effect.
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Abd el Hafiz
authors.forename: M A
authors.initials: MA
authors.lastname: Ramadan
authors.forename: M L
authors.initials: ML
authors.lastname: Jung
authors.forename: J P
authors.initials: JP
authors.lastname: Beck
authors.forename: R
authors.initials: R
authors.lastname: Anton
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic