A novel leishmanicidal labdane from Polyalthia macropoda.
A new diterpene, (4S,9R,10R) methyl 18-carboxy-labda-8,13(E)-diene-15-oate has been obtained from the stem barks of Polyalthia macropoda (Annonaceae). This labdanic derivative was identified on the basis of spectroscopic data and is biologically active against the promastigote Leishmania donovani donovani.
Richomme
P
P
C.E.P.M., Faculté de Pharmacie, Angers, France.
Godet
M C
MC
Foussard
F
F
Toupet
L
L
Sévenet
T
T
Bruneton
J
J
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007893:Leishmania donovani / Q000737:chemistry / Q000187:drug effects*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
D000981:Antiprotozoal Agents; D004224:Diterpenes; C074987:methyl 18-carboxylabda-8,13-diene-15-oate