title: Technological aspect of the production of live dysentery vaccines for oral administration.
abstract: An experimental technology for the production of live freeze-dried vaccines prepared from attenuated Shigella flexneri 2a and Shigella sonnei I strains was developed. It is based on the cultivation of bacterial strains in a fermentor under conditions which ensure high yields. The strains grow in S-form, their antigenic structure is preserved and they remain non-virulent. The attenuating markers are stable. The freeze-dried vaccines retain good immunogenicity when applied intra-intestinally to rats.
authors.affiliation: Institute of Infectious and Parasitic Diseases, Sofia, Bulgaria.
authors.forename: V
authors.initials: V
authors.lastname: Denchev
authors.forename: P
authors.initials: P
authors.lastname: Nenkov
authors.forename: T
authors.initials: T
authors.lastname: Vitanov
authors.forename: T
authors.initials: T
authors.lastname: Sumerska
authors.forename: S
authors.initials: S
authors.lastname: Marinova
authors.forename: T
authors.initials: T
authors.lastname: Vassilev
authors.forename: I
authors.initials: I
authors.lastname: Panova
authors.forename: M
authors.initials: M
authors.lastname: Bratoeva
authors.forename: K
authors.initials: K
authors.lastname: Linde
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D004405:Dysentery, Bacillary / Q000276:immunology*; D005612:Freeze Drying; D006168:Guinea Pigs; D051381:Rats; D012763:Shigella flexneri / Q000254:growth & development / Q000276:immunology*; D012764:Shigella sonnei / Q000254:growth & development / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated