Collagenolytic activity of methylcholanthrene-induced rat fibrosarcoma.
It has been found that the methylcholanthrene-induced rat fibrosarcoma contains an enzyme (probably a cathepsin) which digests type I and type III collagens in acid pH. At physiological pH no proteolytic activity against collagen was found. It may be concluded that the tumour collagen is degraded mainly by the action of cathepsin(s).
Tryniszewska
E A
EA
Department of Biochemistry, Medical Academy, Białystok, Poland.
Bańkowski
E
E
D000818:Animals; D002403:Cathepsins / Q000302:isolation & purification / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D005354:Fibrosarcoma / Q000139:chemically induced / Q000201:enzymology* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008748:Methylcholanthrene; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000201:enzymology* / Q000378:metabolism; D014783:Viscosity
D008748:Methylcholanthrene; D003094:Collagen; D002403:Cathepsins