Aphagic and adipsic effects of interleukin-1.
Intake of rat chow and water was reduced 4 and 8 h after the intrahypothalamic injection of 5 ng interleukin-1a (IL-1a). Although core body temperature was also elevated significantly for at least 4 h by the administration of this cytokine, resting energy expenditure was not altered. These results suggest that IL-1a may be involved in the reduction of feeding associated with trauma, infection or cancer, by inducing early satiety. Additionally, hyperthermia associated with the injection of IL-1a appears to be maintained by decreased heat dissipation rather than by increased thermogenesis.
Chance
W T
WT
Department of Surgery, University of Cincinnati Medical Center, OH 45267.
Fischer
J E
JE
D000704:Analysis of Variance; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004734:Energy Metabolism / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors
D007375:Interleukin-1; D011994:Recombinant Proteins