The effect of the cross-linking time period upon the drug release and the dynamic swelling of gelatin microspheres.
The cross-linking time period affected both the swelling and release processes of cross-linked gelatin microspheres. In the dynamic swelling procedure, the combination of both phenomena of microparticle swelling and drug diffusion produced at first the increase and then the decrease of the diameter of a loaded microsphere. The increase of the cross-linking time period produced the shift of the penetrant transport from anomalous to super-case II kinetics. This behaviour could justify the decrease of the diffusion component of the drug release as the cross-linking time period increased.
Vandelli
M A
MA
Department of Pharmaceutical Sciences, University of Modena, Italy.
Forni
F
F
Coppi
G
G
Cameroni
R
R
D000628:Aminophylline / Q000008:administration & dosage / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003000:Clonidine / Q000008:administration & dosage / Q000737:chemistry; D003432:Cross-Linking Reagents; D004058:Diffusion; D005780:Gelatin / Q000737:chemistry*; D007700:Kinetics; D008863:Microspheres; D014961:X-Ray Diffraction
D003432:Cross-Linking Reagents; D000628:Aminophylline; D005780:Gelatin; D003000:Clonidine