[The effect of periodontal cytomedin on lipid peroxidation and hemostasis in spontaneous periodontitis in rats].
Rats with spontaneous periodontitis develop lipid peroxidation in the blood and periodontal tissues, that is associated with hypercoagulation and fibrinolysis inhibition, reduced antiaggregation activity of the periodontal tissues. Administration of periodontal cytomedin results in normalization of lipid peroxidation, blood coagulation, and euglobulin lysis, as well as in increase in the activities of periodontal antioxidant enzymes and antiaggregation properties. Cytomedin effect on lipid peroxidation and antioxidant enzymes was more manifest in periodontal tissues than in the blood. Visual examination has shown an improvement of the periodontal tissue status, thus indicating good prospects for such therapy.
Mishchenko
V P
VP
Silenko
Iu I
IuI
Khavinson
V Kh
VKh
Tokar'
D L
DL
D000818:Animals; D000975:Antioxidants; D006487:Hemostasis / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use*; D010518:Periodontitis / Q000097:blood / Q000188:drug therapy*; D010519:Periodontium / Q000098:blood supply; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D010455:Peptides; C053892:cytomedins
Vliianie tsitomedina parodonta na sostoianie perekisnogo okisleniia lipidov i gemostaz pri spontannom parodontite u krys.