[The protective effects of paeonol on cultured neonatal rat heart cells during calcium paradox].
It has been found that the rapid (5min) and slow (120min) phases of 15Ca uptake by normal myocardial cells and their beating rate are remarkably inhibited by paeonol. And that paeonol can also decrease 45Ca uptake and lipid peroxide in calcium paradoxical heart cells, which appears in dose-dependence. This indicates that the mechanism of protection of paconol against calcium paradox is associated with its inhibition of Ca2+ influx and antioxidation.
Tang
J
J
Weifang Medical College.
Shi
L
L
D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000098:Acetophenones; D008054:Lipid Peroxides; C013638:paeonol; D002118:Calcium