Developmental control by the Drosophila EGF receptor homolog DER.
The identification of receptor tyrosine kinases in Drosophila has provided an opportunity to study the requirement for these proteins during the development of a multicellular organism. Genetic analysis of the function of the Drosophila epidermal growth factor (EGF) receptor homolog (DER) has revealed an extremely diverse set of roles for this protein throughout the life cycle of the organism, for example in eye development and in the establishment of dorsoventral polarity in the oocyte. We discuss the possible basis for the pleiotropic activity of DER, and the similarities and differences in the function of the homologous proteins in other invertebrates and vertebrates.
Shilo
B Z
BZ
Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel.
Raz
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D000818:Animals; D016764:Cell Polarity; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics / Q000502:physiology*; D004625:Embryo, Nonmammalian / Q000201:enzymology; D047108:Embryonic Development; D005314:Embryonic and Fetal Development; D066246:ErbB Receptors / Q000235:genetics / Q000502:physiology*; D005123:Eye / Q000196:embryology; D005136:Eye Proteins / Q000502:physiology; D008562:Membrane Glycoproteins / Q000502:physiology; D009865:Oocytes / Q000502:physiology; D010641:Phenotype; D010766:Phosphorylation; D011494:Protein Kinases; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases; D018010:Receptors, Invertebrate Peptide; D012689:Sequence Homology, Nucleic Acid; D015398:Signal Transduction
D029721:Drosophila Proteins; D005136:Eye Proteins; D008562:Membrane Glycoproteins; D018010:Receptors, Invertebrate Peptide; D011494:Protein Kinases; C066532:Egfr protein, Drosophila; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; C056737:sev protein, Drosophila