title: Conformation and quantification of chloramphenicol in cow's urine, muscle and eggs by electron capture negative ion chemical ionization gas chromatography/mass spectrometry.
abstract: A method is described for the determination of residues of the antibiotic chloramphenicol in biological samples. The method is based on gas chromatography/negative ion chemical ionization mass spectrometry and uses (37Cl2)chloramphenicol as internal standard. Selective ion monitoring of four analyte-specific ions enables the determination of chloramphenicol levels in urine of 3 micrograms l-1 with a coefficient of variation of 8%. The limit of detection of the method is 0.1 p.p.b. for urine, muscle and egg.
authors.affiliation: National Institute of Public Health and Environmental Protection, Laboratory of Organic-Analytical Chemistry, Bilthoven, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: van der Heeft
authors.forename: A P
authors.initials: AP
authors.lastname: de Jong
authors.forename: L A
authors.initials: LA
authors.lastname: van Ginkel
authors.forename: H J
authors.initials: HJ
authors.lastname: van Rossum
authors.forename: G
authors.initials: G
authors.lastname: Zomer
mesh_terms: D000818:Animals; D002417:Cattle; D002701:Chloramphenicol / Q000032:analysis* / Q000652:urine; D004350:Drug Residues / Q000032:analysis*; D004531:Eggs / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D009132:Muscles / Q000737:chemistry*
chemical_list: D002701:Chloramphenicol