Oestrogen receptors in well differentiated thyroid cancers.
Oestrogen receptor (ER) monoclonal antibody, H222 was used to study ER expression in forty-seven paraffin embedded blocks of well differentiated thyroid cancers. Trypsinisation, DNase I digestion, together with the use of labelled streptavidin biotin immuno-histochemical staining kit were adopted to increase the sensitivity of the immunoreaction. One out of twenty-seven papillary carcinomas and one out of twenty follicular carcinomas were immunoreactive. Thus, 4.3% of the well differentiated thyroid cancers were noted to express ER. The increased incidence and the better prognosis in females with well differentiated thyroid cancers is unlikely to be explained on the presence or absence of ER.
Hong
G S
GS
Department of Surgery, Singapore General Hospital.
Sng
I T
IT
Soo
K C
KC
D000230:Adenocarcinoma / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D002291:Carcinoma, Papillary / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D011960:Receptors, Estrogen