title: X-ray analysis of a difluorostatone renin inhibitor bound as the tetrahedral hydrate to the aspartic protease endothiapepsin.
authors.affiliation: Department of Medicinal Chemistry, Central Research Division, Pfizer, Inc., Groton, CT 06340.
authors.forename: D J
authors.initials: DJ
authors.lastname: Hoover
authors.forename: B
authors.initials: B
authors.lastname: Veerapandian
authors.forename: J B
authors.initials: JB
authors.lastname: Cooper
authors.forename: D B
authors.initials: DB
authors.lastname: Damon
authors.forename: B W
authors.initials: BW
authors.lastname: Dominy
authors.forename: R L
authors.initials: RL
authors.lastname: Rosati
authors.forename: T L
authors.initials: TL
authors.lastname: Blundell
mesh_terms: D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors / Q000737:chemistry*; D001665:Binding Sites; D006801:Humans; D066298:In Vitro Techniques; D008958:Models, Molecular; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry; D011487:Protein Conformation; D014961:X-Ray Diffraction; D000092502:Renin Inhibitors
chemical_list: D016282:Aspartic Acid Endopeptidases; D009842:Oligopeptides; D000092502:Renin Inhibitors; C074407:CP 81282; C042466:Endothia aspartic proteinase