Correlations between aminoglycoside pharmacokinetic parameters and patient's factors: from statement to implication for individual dosage design.
Amikacin pharmacokinetics was studied in 20 critically ill patients after a single i.v. bolus dose (500 mg). The amikacin pharmacokinetic profiles were characterized by marked intra-individual variability. Stepwise multivariate regression analysis made it possible to establish statistically significant correlations between the amikacin total clearance (Cl) and 8 patient's factors such as the, age, sodium plasma content, plasma osmolarity, partial pressure of oxygen and carbon dioxide, volumes of transfused plasma and blood, application of artificial lung ventilation (r2 = 0.98). The multiple regression equation for the Cl prediction provides reliable indirect estimation of the parameter. Thus, it appears possible to adjust the aminoglycoside dosage by taking into account 8 patient's factors, until the amikacin plasma concentration, time data are available.
Firsov
A A
AA
National Research Institute of Antibiotics, Moscow, USSR.
Nasonov
V N
VN
D000328:Adult; D000375:Aging / Q000378:metabolism; D000583:Amikacin / Q000008:administration & dosage / Q000493:pharmacokinetics; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001803:Blood Transfusion; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012044:Regression Analysis; D012121:Respiration, Artificial; D014882:Water-Electrolyte Balance / Q000502:physiology
D000900:Anti-Bacterial Agents; D000583:Amikacin