title: [The immunopathology of type I diabetes mellitus].
abstract: The onset of type I diabetes is preceded by a prodromic phase during which, despite the absence of symptoms, the beta-cell mass decreases as a result of an autoimmune process. In this review we discuss the importance of environmental and genetic factors, and abnormalities of humoral and cellular immunity in the development of autoimmune process toward pancreatic beta cells. The resulting immunological network involves monocytes activation, interleukin-1 secretion, T-lymphocyte activation, secretion of interleukin-2 and other lymphokines which activate cytotoxic cells to induce beta-cell lysis.
authors.affiliation: Ospedale S. Spirito in Sassia, Roma.
authors.forename: C
authors.initials: C
authors.lastname: Cianti
authors.forename: A
authors.initials: A
authors.lastname: Toscano
authors.forename: A
authors.initials: A
authors.lastname: Piccinin
authors.forename: A
authors.initials: A
authors.lastname: Cabras
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000473:pathology; D006801:Humans
vernacular_title: Immunopathologia del diabete mellito di tipo I.