title: The stability of proton T2 effects of oxygen-17 water in experimental cerebral ischemia.
abstract: The gerbil model of unilateral cerebral ischemia has been used to test the temporal and spatial stability of the MRI T2 effects of oxygen-17 water. Following unilateral carotid ligation, symptomatic animals were given a single large intraperitoneal injection of H2(17)O and the distribution and stability of the brain T2 effects were followed with a spin-echo sequence. In contrast to the ischemic areas, the perfused tissue shows a marked and prolonged loss in intensity with little evidence of diffusion of the T2 effect of 17O into the ischemic tissue.
authors.affiliation: Department of Anatomy, Case Western Reserve University, Cleveland, Ohio.
authors.forename: A L
authors.initials: AL
authors.lastname: Hopkins
authors.forename: W D
authors.initials: WD
authors.lastname: Lust
authors.forename: E M
authors.initials: EM
authors.lastname: Haacke
authors.forename: P
authors.initials: P
authors.lastname: Wielopolski
authors.forename: R G
authors.initials: RG
authors.lastname: Barr
authors.forename: C B
authors.initials: CB
authors.lastname: Bratton
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D005849:Gerbillinae; D007274:Injections, Intraperitoneal; D008279:Magnetic Resonance Imaging; D008297:Male; D010104:Oxygen Radioisotopes; D014867:Water / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water