Sodium chloride-induced hypergastrinaemia in rats.
In this study the effect of Nac1 on plasma immunoreactive gastrin was investigated. I.P. administration of sodium chloride (0.9%) in a dose of 1 ml/kg.b.w. for 7 days in rats, produced a significant rise in level of sodium ion in plasma. This hypernatraemia was also accompanied by significant rise in values of plasma immunoreactive gastrin. The mechanism(s) of this sodium chloride-induced release of gastrin is discussed.
Awad
H A
HA
Physiology Department, Faculty of Medicine, Ain Shams University.
D000818:Animals; D005069:Evaluation Studies as Topic; D005755:Gastrins / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*
D005755:Gastrins; D012965:Sodium Chloride