IL-1 alpha inhibits lymphocyte migration into a site of chronic inflammation.
The effects of murine recombinant IL-1 alpha (muIL-1 alpha) on lymphocyte migration in the mouse have been investigated. Continuous infusion of muIL-1 alpha had marked effects on patterns of lymphocyte migration into a site of chronic inflammation, inflammatory exudate and spleen; the numbers of lymphocytes migrating to the inflamed tissue and spleen were reduced in a dose-dependent manner. The number of lymphocytes in the blood of muIL-1 alpha-treated animals was increased in a dose-related manner. The decrease in numbers of lymphocytes present in the chronically inflamed site may either be due to a direct inhibitory action of muIL-1 alpha or reflect an increased rate of cell migration through the inflamed tissues accompanied by a more rapid return to the circulation. These findings suggest that IL-1 alpha may act not only as an inflammatory cytokine, but also as a modulator with anti-inflammatory activity during chronic inflammation.
Dawson
J
J
Department of Pharmacology, Royal Veterinary College, Hatfield, Hertfordshire.
Edwards
J C
JC
Sedgwick
A D
AD
Lees
P
P
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D002908:Chronic Disease; D003864:Depression, Chemical; D005122:Exudates and Transudates; D005260:Female; D007249:Inflammation / Q000473:pathology*; D007375:Interleukin-1 / Q000494:pharmacology*; D007958:Leukocyte Count / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D010567:Pertussis Vaccine / Q000633:toxicity; D011994:Recombinant Proteins / Q000494:pharmacology; D013154:Spleen / Q000473:pathology
D007375:Interleukin-1; D010567:Pertussis Vaccine; D011994:Recombinant Proteins