title: Single-dose inhaled budesonide in subjects with chronic asthma.
abstract: In 30 stable asthmatics, a comparison was made between the changes in pulmonary function (FEV1, FVC, PEF, MEF75, MEF50 and MEF25) hourly for 9 h after a single dose of inhaled budesonide 1,600 micrograms, and placebo. All subjects used inhaled steroids daily; this medication was, however, withheld 8 days prior to the study. For all parameters of pulmonary function, a significant difference in favour of budesonide was demonstrated. The effect tended to decrease after 9 h, and had abated within 24 h. FEV1 age, sex, smoking habits, or results of an inhaled beta 2-agonist reversibility test could not be demonstrated as predictors of those subjects to react with the most pronounced responses to budesonide. In conclusion, our results demonstrate an effect 3 h after administration of an inhaled glucocorticosteroid in adult outpatients with chronic asthma. These results parallel previous findings in highly selected asthmatics and after systemic administration of glucocorticosteroids. Single-dose administration and subsequent monitoring for 8-9 h may therefore prove valuable in evaluating new prophylactic agents for the treatment of asthma.
authors.affiliation: Allergy Unit, Medical Department TTA, National University Hospital, Copenhagen, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Engel
authors.forename: A
authors.initials: A
authors.lastname: Dirksen
authors.forename: J H
authors.initials: JH
authors.lastname: Heinig
authors.forename: N H
authors.initials: NH
authors.lastname: Nielsen
authors.forename: B
authors.initials: B
authors.lastname: Weeke
authors.forename: S A
authors.initials: SA
authors.lastname: Johansson
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D019819:Budesonide; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011282:Pregnenediones / Q000008:administration & dosage*
chemical_list: D001993:Bronchodilator Agents; D011282:Pregnenediones; D019819:Budesonide