title: Increased endothelin excretion in rats with renal failure induced by partial nephrectomy.
abstract: 1. Six weeks following partial nephrectomy in rats, significant increases in serum urea nitrogen and serum creatinine concentration and a significant decrease in creatinine clearance were observed. 2. Measurement of systolic blood pressure by tail plethysmography indicated that animals that had undergone partial nephrectomy were hypertensive. 3. Compared to sham-operated animals, there were 4 fold increases in both urinary protein excretion and urinary endothelin excretion. 4. There was a significant correlation between urinary protein and urinary endothelin excretion (r = 0.77). There was also a correlation (r = 0.65) between urinary endothelin excretion and systolic blood pressure. 5. Plasma endothelin concentrations were not different in sham-operated and partially nephrectomized rats. 6. The data indicate that there is an increased renal endothelin production in rats with chronic renal failure.
authors.affiliation: SmithKline Beecham Pharmaceuticals, Department of Pharmacology, King of Prussia, PA 19406-0939.
authors.forename: D P
authors.initials: DP
authors.lastname: Brooks
authors.forename: L C
authors.initials: LC
authors.lastname: Contino
authors.forename: B
authors.initials: B
authors.lastname: Storer
authors.forename: E H
authors.initials: EH
authors.lastname: Ohlstein
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D016232:Endothelins / Q000652:urine*; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000652:urine*; D008297:Male; D009392:Nephrectomy; D011507:Proteinuria / Q000652:urine; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D016232:Endothelins; D003404:Creatinine