title: Synthesis of a 3-ether analogue of lipid A.
abstract: Lipid A 3-ether analogues were synthesized from allyl 2-deoxy-4,6-O-isopropylidene-2-trifluoroacetamido-alpha-D-glucopyr anoside and 3,4,6-tri-O-acetyl-2-trifluoroacetamido-alpha-D-glucopyranosyl bromide. The compound lost completely the endotoxic activity.
authors.affiliation: New Lead Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shiozaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Arai
authors.forename: N
authors.initials: N
authors.lastname: Ishida
authors.forename: T
authors.initials: T
authors.lastname: Hiraoka
authors.forename: M
authors.initials: M
authors.lastname: Nishijima
authors.forename: S
authors.initials: S
authors.lastname: Kuge
authors.forename: T
authors.initials: T
authors.lastname: Otsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Akamatsu
mesh_terms: D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D004926:Escherichia coli; D007202:Indicators and Reagents; D008050:Lipid A / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D007202:Indicators and Reagents; D008050:Lipid A