Effect of BIM-18216, a novel cholecystokinin receptor antagonist, on food intake reduction induced by cholecystokinin.
The role of cholecystokinin (CCK) in food intake was investigated in rats by using BIM-18216, a novel CCK receptor antagonist. In rats fed 6 hr/day, BIM-18216 antagonized the reduction of food intake induced by exogenous CCK octapeptide (CCK-8; 4 micrograms/kg) in a dose-dependent manner and had a maximum effect at 1 mg/kg. BIM-18216 did not antagonize the effect of bombesin on food intake and showed some degree of specificity. BIM-18216 was not able to prevent the effect of endogenous CCK at the beginning of the feeding period. These data demonstrate that BIM-18216 is a potent CCK-specific antagonist. These results also suggest that endogenous and exogenous CCK could act by different regulating pathways.
Laferrere
B
B
Service de Médecine et Nutrition, Hôpital Hôtel-Dieu de Paris, France.
Nguyen
M
M
Bonhomme
G
G
Legall
A
A
Basdevant
A
A
Guy-Grand
B
B
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D001839:Bombesin / Q000494:pharmacology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors; D020109:Devazepide; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D012528:Satiety Response / Q000187:drug effects; D012844:Sincalide / Q000494:pharmacology*
C074760:BIM 18216; D001570:Benzodiazepinones; D011949:Receptors, Cholecystokinin; D001569:Benzodiazepines; D002766:Cholecystokinin; D020109:Devazepide; D012844:Sincalide; D001839:Bombesin