title: [The action of albendazole on the broad tapeworm].
abstract: Studies of the effects of the anthelminthic agent albendazole on the tissues of D. latum in vivo showed large shapeless protrusions of the outer tegumental cytoplasm on the surface of strobila, the mitochondrial degeneration in the tegumental cells and their nucleolar material segregation. After in vitro treatment cavitary formations in the outer tegumental syncytium, muscular fascicle loosening, decreased glycogen levels, and altered secret granules in the vitellaria were found. Thus, albendazole might affect the biochemical system of the parasite, since there is a relationship between some biochemical processes and morphological changes.
authors.forename: N M
authors.initials: NM
authors.lastname: Molodozhnikova
authors.forename: A V
authors.initials: AV
authors.lastname: Volodin
authors.forename: N G
authors.initials: NG
authors.lastname: Bakulina
mesh_terms: D015766:Albendazole / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D006224:Cricetinae; D004169:Diphyllobothriasis / Q000188:drug therapy / Q000469:parasitology; D004170:Diphyllobothrium / Q000187:drug effects* / Q000302:isolation & purification / Q000648:ultrastructure; D004353:Drug Evaluation, Preclinical; D007814:Larva / Q000187:drug effects / Q000302:isolation & purification / Q000648:ultrastructure; D008647:Mesocricetus; D012487:Salmonidae / Q000469:parasitology; D013997:Time Factors
chemical_list: D015766:Albendazole
vernacular_title: Deĭstvie al'bendazola na lentesa shirokogo.