Long-chain phenols from the bark of Amphypterygium adstringens.
The hexane extract of the stem bark of Amphypterygium adstringens at a dose of 100 mg/kg subcutaneously exhibited significant hypocholesterolemic effect on 24-h fasted rats, lowering the cholesterol levels by 31%, an effect similar to 15 mg/kg estrone given by the same route. Column chromatography of the active extract allowed the isolation of two mixtures of long chain phenols (Mixture I and Mixture II). According to GC/MS analysis, Mixture I contained five alkyl phenolic acids and Mixture II three alkyl phenolic aldehydes. Neither of the mixtures exhibited significant hypocholesterolemic activity at doses up to 15 mg/kg subcutaneously.
Mata
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Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, D.F.
Calzada
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Navarrete
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A
del Rio
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Delgado
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G
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002845:Chromatography / Q000379:methods; D005215:Fasting / Q000502:physiology; D008401:Gas Chromatography-Mass Spectrometry; D006586:Hexanes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010636:Phenols / Q000032:analysis / Q000494:pharmacology*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains
D006586:Hexanes; D010636:Phenols; D010936:Plant Extracts; C026385:n-hexane; D002784:Cholesterol