Age of appearance of circadian rhythm in blood 17-hydroxyprogesterone in 21-hydroxylase deficiency.
Sixty-one daily profiles of blood-spot 17-hydroxyprogesterone derived from patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency were analysed to determine the age of appearance of circadian rhythm in hypothalamo-pituitary-adrenal activity. The results revealed that typical circadian adrenocortical rhythm is established at approximately three months after birth. In conclusion, the maturation of supra-hypothalamic brain structure proceeds normally also in humans with constant low level of cortisol in blood.
Sólyom
J
J
2nd Department of Paediatrics, Semmelweis University Medical School, Budapest, Hungary.
D019326:17-alpha-Hydroxyprogesterone; D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000201:enzymology; D000375:Aging / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology; D011863:Radioimmunoassay
D006908:Hydroxyprogesterones; D019326:17-alpha-Hydroxyprogesterone