Improvement in allograft survival of islets of Langerhans by pretreatment with deoxyguanosine.
In vitro pretreatment of isolated islets of Langerhans prior to transplantation with deoxyguanosine (dGuo) was found to be effective in improving the survival in fully allogeneic diabetic rats (Wistar----PVG). Post transplant immunosuppression was not used. Islets pretreated with various concentrations of dGuo, 1, 1.35, 1.5 and 2 microM dGuo per islet showed a graft survival of 9, 36, 9 and 14% respectively.
al-Abdullah
I H
IH
Department of Surgery, Hahnemann University, Philadelphia, Pennsylvania 19102.
Kumar
M S
MS
al-Adnani
M S
MS
Abouna
G M
GM
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003849:Deoxyguanosine / Q000494:pharmacology* / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000601:surgery*; D006085:Graft Survival / Q000187:drug effects; D016381:Islets of Langerhans Transplantation / Q000473:pathology / Q000502:physiology*; D008099:Liver / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous
D001786:Blood Glucose; D003849:Deoxyguanosine