title: [Metabolic N- and S-oxygenation of dokloxytepin in vitro].
abstract: Dokloxytepin in the medium of the induced monooxygenase system of the microsomal fraction of the liver of the rat, rabbit and mice is metabolized into three metabolites: two identical, i.e., N-oxide and 5-sulfoxide, and a third different one. In the rat and rabbit it is the hitherto unknown metabolite M1, and in the mouse S,N-dioxide of dokloxytepin. The metabolites were identified by thin-layer chromatography by comparing with synthetic standards.
authors.affiliation: Katedra biochemie a mikrobiologie farmaceutické fakulty Univerzity Komenského, Bratislava.
authors.forename: O
authors.initials: O
authors.lastname: Helia
authors.forename: I
authors.initials: I
authors.lastname: Pauliková
mesh_terms: D000818:Animals; D003988:Dibenzothiepins / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D010084:Oxidation-Reduction; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003988:Dibenzothiepins; C019360:docloxythepin
vernacular_title: Metabolická N- a S-oxygenace dokloxytepinu in vitro.