Comparative pharmacokinetics and distribution of human urinary erythropoietin and recombinant human erythropoietin in rats.
Comparative pharmacokinetic and distribution studies of human recombinant erythropoietin (rh-EPO, Epoch, CAS 11096-26-7) and human urinary erythropoietin (u-EPO) were performed in rats. The pharmacokinetic parameters following intravenous administration of rh-EPO were similar to those of u-EPO. With respect to the concentrations of radioactivity in the liver reflecting uptakes of asialoglycoprotein, there were no differences in the concentrations between 125I-rh-EPO and 125I-u-EPO. The concentrations of radioactivity in the target organs, i.e., bone marrow and spleen in rats given 125I-rh-EPO were very similar to those of rats given 125I-u-EPO. These facts are most likely to reflect the similarity in pharmacological action.
Kinoshita
H
H
Drug Metabolism Laboratory, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.
Ohishi
N
N
Kato
M
M
Tokura
S
S
Okazaki
A
A
D000818:Animals; D004921:Erythropoietin / Q000235:genetics / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000652:urine; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D011994:Recombinant Proteins; D004921:Erythropoietin