title: Effect of delmopinol on in vitro dental plaque formation, bacterial acid production and the number of microorganisms in human saliva.
abstract: This study investigated the effect of a surface active compound, delmopinol, on plaque formation and established plaque in vitro, on the bacterial acid production from glucose and on the total viable bacterial counts in saliva. The antimicrobial effect was compared with that of chlorhexidine. The plaque-inhibiting effect was evaluated in an artificial mouth system, and the effect on bacterial acid production was registered as a decrease of pH in bacterial suspensions with various concentrations of delmopinol. It was shown that delmopinol is able to prevent plaque formation, to dissolve established plaque in vitro, and that it has 5-125 times higher minimum inhibitory concentrations than chlorhexidine. Saliva samples collected 1 min after rinsing with delmopinol showed on differences in the total number of bacteria in saliva as compared with controls. It was also shown that the bacterial acid production from glucose was reduced successively with increasing concentrations of delmopinol. The results indicate that delmopinol might be as effective as chlorhexidine against plaque formation and that delmopinol is capable of penetrating established plaque, thus promoting a more effective mechanical cleansing.
authors.affiliation: Biology Department, School of Dentistry, Malmö, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Simonsson
authors.forename: E B
authors.initials: EB
authors.lastname: Hvid
authors.forename: J
authors.initials: J
authors.lastname: Rundegren
authors.forename: S
authors.initials: S
authors.lastname: Edwardsson
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002710:Chlorhexidine / Q000494:pharmacology / Q000627:therapeutic use; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000517:prevention & control*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009025:Morpholines / Q000494:pharmacology* / Q000627:therapeutic use; D012463:Saliva / Q000382:microbiology*; D013501:Surface-Active Agents / Q000494:pharmacology*
chemical_list: D000891:Anti-Infective Agents, Local; D009025:Morpholines; D013501:Surface-Active Agents; C073738:delmopinol; D005947:Glucose; D002710:Chlorhexidine