[Indicators of erythro- and immunopoiesis in the development of autoimmune disease induced by graft vs host reaction].
Erythropoiesis and immunity are evaluated in (C57BL/6xDBA/2) F1 mice with immune complex glomerulonephritis induced by GVHR as compared to the genetically determined models of systemic lupus erythematosus. Elevated content of serum blood antinuclear antibodies, polyclonal activation during early disease periods, immune complex deposition in kidney tissues indicate the presence of the autoimmune syndrome in (C57BL/6xDBA/2)F1 mice, similar to that in mice with genetic lupus nephritis. The findings of a decrease of CFUs on days 5 and 8 at early times of disease, a reduction of hematocrit in combination with the enhancement of stem cell proliferation on the 6th-7th month of disease, an increase of the absolute leukocyte count and relative monocyte count in the peripheral blood of diseased mice may attest to the depression of stem cell differentiation in erythropoiesis and to the enhancement of stem cell differentiation in granulocyto-monocytopoiesis, that needs, however, further research and confirmation.
Kolesnikova
O P
OP
Kudaeva
O T
OT
Loginov
V A
VA
Robinson
M V
MV
Kolesnikova
S M
SM
Kozlov
V A
VA
D000818:Animals; D000974:Antibodies, Antinuclear / Q000096:biosynthesis / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000209:etiology* / Q000276:immunology; D004195:Disease Models, Animal; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000276:immunology* / Q000473:pathology; D004920:Erythropoiesis / Q000276:immunology*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000209:etiology* / Q000276:immunology; D007958:Leukocyte Count; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013154:Spleen / Q000166:cytology*
D000974:Antibodies, Antinuclear
Pokazateli éritro- i immunopoéza v razvitii autoimmunnogo zabolevaniia, indutsirovannogo reaktsieĭ transplantant protic khoziaina.