[Anti-ulcerogenic action of a combination of a psychostimulator of the phenylalkylsydnone imine series and arginine].
It has been revealed that OF 743, one of the psychostimulators belonging to phenylalkylsydnonimine derivatives, exerts anti-ulcerogenic action in case of stress- and ethanol-induced damage of gastric mucosa in rats. However OF 743 was not effective in case of indomethacin-induced gastric mucosal damage. Complex administration of OF 743 and arginine was accompanied by a considerable decrease of indomethacin-induced gastric mucosal damage. That combination was more effective than OF 743 alone in case of ethanol-induced gastric mucosal damage.
Samonina
G E
GE
Natsvlishvili
N A
NA
Ashmarin
I P
IP
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001120:Arginine / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D000431:Ethanol / Q000037:antagonists & inhibitors; D005753:Gastric Mucosa / Q000187:drug effects; D007213:Indomethacin; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology; D013558:Sydnones / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D000928:Antidepressive Agents; D013558:Sydnones; C072808:OF 743; D000431:Ethanol; D001120:Arginine; D007213:Indomethacin
Antiul'tserogennoe deĭstvie kombinatsii psikhostimuliatora fenilalkilsidnoniminovogo riada i arginina.