Hemodynamic effects of the D- and L-isomers of sotalol on normal myocardium.
This study investigated the hemodynamic effects of the D-isomer of sotalol in open-chest rats and compared this to the action of the L-isomer and the racemic DL-sotalol. Hemodynamic and additional isovolumic maximum measurements were registered at the end and 5 minutes after an intravenous infusion period of 7 minutes. DL- (1 and 2 mg/kg) and L-sotalol (2 mg/kg) caused a significant reduction in the heart rate and in the indices of contractility during and after infusion. D-sotalol (2, 4, and 8 mg/kg), however, decreased the contractility only transiently after very high doses at high plasma concentrations. Thus, while the effects of the beta-blocking L-isomer were comparable to those of DL-sotalol, only a slight and transient hemodynamic action of comparable doses of D-sotalol was found. These findings may be of significance for the proposed use of the D-isomer as a class-III antiarrhythmic agent.
Hoffmeister
H M
HM
Medizinische Klinik, Abt. III, Universität Tübingen, Germany.
Beyer
M
M
Seipel
L
L
D000818:Animals; D001826:Body Fluids / Q000502:physiology; D004562:Electrocardiography / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013015:Sotalol / Q000097:blood / Q000494:pharmacology*; D013237:Stereoisomerism; D013599:Systole / Q000187:drug effects / Q000502:physiology
D013015:Sotalol