title: [Circulating lymphocyte populations and B-cell differentiation in a young female patient with multicentric giant lymph node hyperplasia].
abstract: Giant multicentric hyperplasia of the lymph nodes (GMHLN) is currently regarded as a disseminated form of angiofollicular lymphoid hyperplasia, or Castleman's disease. An immunologic study was carried out on a 24 year-old Caucasian woman who was admitted to hospital with generalised lymph node enlargement, jaundice and fever, and showed an excellent response to steroid therapy. No alterations were found in the lymphocytic subsets, the intrinsic B cell function or the T-B cooperative capability. These data disagree with the hypothesis than GMHLN is due to a deficiency of the T cell suppressive function with concomitant immunoglobulin over-production.
authors.affiliation: Departamento de Clínica Hematológica, Academia Nacional de Medicina de Buenos Aires, Argentina.
authors.forename: M F
authors.initials: MF
authors.lastname: Palacios
authors.forename: C G
authors.initials: CG
authors.lastname: Fondevilla
authors.forename: J
authors.initials: J
authors.lastname: Fernández
authors.forename: N H
authors.initials: NH
authors.lastname: González
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000175:diagnosis; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D005871:Castleman Disease / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D002454:Cell Differentiation; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D008211:Lymphocyte Cooperation; D016131:Lymphocyte Subsets / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D011241:Prednisone
vernacular_title: Poblaciones linfocitarias circulantes y diferenciación B en una paciente joven con hiperplasia gigante multicéntrica de los ganglios linfáticos.