Gastric antisecretory activity of 15(R)-15-methylprostaglandin E2, arbaprostil, in dogs.
The gastric antisecretory activity of 15(R)-15-methylprostaglandin E2 (arbaprostil) was compared with that of natural prostaglandin (PG) E2 in Pavlov pouch dogs. Arbaprostil significantly inhibited pentagastrin- and food-stimulated gastric secretion when it was administered directly into the pouch at a dose of 10-30 micrograms/pouch and 30-300 micrograms/pouch, respectively. Natural PGE2, however, was inactive up to 1000 micrograms/pouch. The data indicate that arbaprostil is a potent, long-acting orally active antisecretory drug that may be useful for the treatment of peptic ulcer disease.
Takanashi
H
H
Department of Pharmacology, Chugai Pharmaceutical Co., Ltd., Shizuoka, Japan.
Itoh
Z
Z
D000818:Animals; D001101:Arbaprostil / Q000009:adverse effects / Q000494:pharmacology*; D003967:Diarrhea / Q000139:chemically induced; D015232:Dinoprostone / Q000009:adverse effects / Q000494:pharmacology; D004285:Dogs; D004435:Eating / Q000502:physiology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
D010418:Pentagastrin; D015232:Dinoprostone; D001101:Arbaprostil