[The growth-inhibiting activity of mixed complexes of platinum(II) with ammonia and cycloalkylamines].
The effect was studied of mixed cys- and 3-, 4-, 5-, 6-nomial cycloalkylamines or substituted 2-, 3-, 4-methyl- and 4-hydroxycyclohexylamines as well as similar carboxylatocomplexes containing anions of malonic hydroxymalonic, succinic and malic acids on the growth of corn sprout roots. Complexes with non-substituted cycloalkylamines possessed the most pronounced cytostatic activity. Complexes with substituted cyclohexylamines were less active than their non-substituted analogue as well as other complexes with lesser size of cyclic substitute. The cytostatic activity of carboxylatocomplexes, as compared to that of chlorocomplexes, generally manifested itself at ten times higher concentraiton and depended not only on the size of cycloalkylamine but also on the nature of acidoligand.
Bystrova
E I
EI
Ivanov
V B
VB
Chel'tsov
P A
PA
D000588:Amines / Q000494:pharmacology*; D000641:Ammonia / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D003514:Cyclohexylamines / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D008024:Ligands; D013329:Structure-Activity Relationship; D013997:Time Factors; D003313:Zea mays / Q000187:drug effects / Q000254:growth & development
D000588:Amines; D000970:Antineoplastic Agents; D003514:Cyclohexylamines; D008024:Ligands; D000641:Ammonia; D002945:Cisplatin
Rostingibiruiushchaia aktivnost' smeshannykh kompleksov platiny(II) s ammiakom i tsikloalkilaminami.