title: [Li+ as a Na+ analog in ion transport process in vertebrates].
abstract: Special features of Li+ transport in several organs ensuring ion homeostasis of vertebrates (in kidneys of fishes and mammals, in gills of teleost and rectal gland of elasmobranchs) are observed in comparison to Na+ transport in the same organs. Transport processes in extrarenal excretory organs--in gills of marine teleosts and in rectal gland of marine elasmobranchs--are distinguished by low lithium-sodium selectivity, i.e. in these processes Li+ behaves very much like Na+. On the contrary, renal excretion of these ions is accompanied by significant (more than ten times) increase of [Li]/[Na] ratio in urine in comparison with that of blood plasma. At the same time, there is no difference between Li+ and Na+ in process of glomerular filtration and their transfer across proximal tubule wall; discrimination takes place in distal parts of a nephron where Li+ is not involved in the process of Na+ reabsorption. Data on lithium-sodium selectivity of the kidneys and rectal gland were obtained by a direct measurement of Li+ and Na+ concentrations in body fluids. Estimations of lithium sodium-selectivity of gills of freshwater and marine teleosts were performed by means of the balance equation of Li+ and Na+ net fluxes in processes of exchange between the animal and its environment.
authors.forename: D G
authors.initials: DG
authors.lastname: Fleĭshman
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D005399:Fishes; D005880:Gills / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008094:Lithium / Q000378:metabolism*; D008322:Mammals; D010481:Perianal Glands / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D014714:Vertebrates / Q000378:metabolism*
chemical_list: D008094:Lithium; D012964:Sodium
vernacular_title: Li+ kak analog Na+ v nekotorykh protsessakh ionnogo transporta u pozvonochnykh.