[T-lymphocyte subsets of peripheral blood monocytes and their ability to form T-cell colony in breast tumor].
T-lymphocyte subsets and their ability to form T-lymphocyte colony were studied in 29 patients with breast cancer, 13 patients with benign breast diseases, and 28 normal females. Cellular immunity was found suppressed in breast cancer patients with an abnormally elevated percentage of OKT8. There were a reversed ratio of T4/T8, low T-cell proliferation, and some immunity-suppressing factors in the peripheral blood. These abnormalities were most evident in stage III breast cancer patients. The ratio of T4/T8 increased significantly and the colony formation of T cells greatly improved (P less than 0.001) 5-6 months after radical mastectomy in 7 patients, It is suggested that immune suppression of tumor is strengthened after surgery.
Zhang
L H
LH
Second Affiliated Hospital, Hunan Medical University, Changsha.
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood / Q000276:immunology*; D016516:CD4-CD8 Ratio; D003114:Colony-Forming Units Assay; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*