[Status epilepticus in chronically dialyzed patients treated with erythropoietin].
This paper describes the clinical features of two patients with chronic renal failure and uremic anaemia treated with recombinant human erythropoietin (9000 I.U. subcutaneously subdivided in 3 times weekly at the end of haemodialysis treatment) who developed seizures and status epilepticus. This treatment has unequivocal benefits but in some patients has been accompanied by elevated blood pressure leading to hypertensive encephalopathy with seizures. In fact, the correction of the anaemia results in a rise in packed cell volume with a consequent increase in blood viscosity, predisposing to increased vascular resistance and the development of hypertension.
Massetani
R
R
Cattedra di Neurofisiopatologia, Università di Pisa.
Galli
R
R
Calabrese
R
R
Sartucci
F
F
Rindi
P
P
Severino Brandi
L
L
Murri
L
L
D000328:Adult; D000740:Anemia / Q000209:etiology / Q000628:therapy; D001809:Blood Viscosity / Q000187:drug effects; D002545:Brain Ischemia / Q000209:etiology / Q000503:physiopathology; D004921:Erythropoietin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000139:chemically induced / Q000150:complications; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D006435:Renal Dialysis / Q000009:adverse effects; D013226:Status Epilepticus / Q000209:etiology* / Q000503:physiopathology; D014661:Vasoconstriction
D011994:Recombinant Proteins; D004921:Erythropoietin
Stato di male epilettico in pazienti dializzati cronici trattati con eritropoietina.