Investigations of animal blood samples after fragrance drug inhalation by gas chromatography/mass spectrometry with chemical ionization and selected ion monitoring.
The fragrance compounds linalool (1) and linalyl acetate (2) could be detected, identified and quantified (1: 7-9 ng ml-1; and 2: 1-2 ng ml-1 and 4-5 ng ml-1 as free linalool) in blood samples after inhalation in animal experiments (mice) by gas chromatography/mass spectrometry (GC/MS) with chemical ionization (CI) (ammonia); selected ion monitoring (SIM) mode (1: m/z 81, 137 and 154; 2: 47, 57 and 137) and GC/flame ionization detection (FID). The inhalation of these monoterpenes in concentrations of 5 mg l-1 air leads to a significant reduction of the motility of the test animals down to 30-40% with respect to the control group.
Jirovetz
L
L
Institute of Pharmaceutical Chemistry, University of Vienna, Austria.
Jäger
W
W
Buchbauer
G
G
Nikiforov
A
A
Raverdino
V
V
D000080462:Acyclic Monoterpenes; D000280:Administration, Inhalation; D000818:Animals; D003864:Depression, Chemical; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D051379:Mice; D039821:Monoterpenes; D009068:Movement / Q000187:drug effects; D010476:Perfume / Q000008:administration & dosage*; D013729:Terpenes / Q000008:administration & dosage* / Q000097:blood
D000080462:Acyclic Monoterpenes; D039821:Monoterpenes; D010476:Perfume; D013729:Terpenes; C074463:linalyl acetate; C018584:linalool