Gallbladder contraction after administration of intravenous amino acids and long-chain triacylglycerols in humans.
We examined the possible physiologic effects of intravenous (IV) amino acids (AAs) and long-chain triacylglycerols (LCTs) on gallbladder (GB) motility and release of cholecystokinin (CCK) on humans. GB contraction was studied in normal volunteers after administration of a fatty meal and IV infusion of AA and LCT. The GB contraction volume was calculated with ultrasound. Cholecystokinin-8 (CCK-8) and cholecystokinin-33/39 (CCK-33/39) were measured by radio-immunoassay. Administration of a fatty meal resulted in GB contraction by 60% of its basal volume and was accompanied by an increase in the serum levels of both CCK-8 and CCK-33/39. Administration of IV AA and LCT resulted in GB contraction by 17 and 37%, respectively, of its basal volume. The latter contractions were accompanied by increased levels of CCK-8 only. We conclude that IV administration of AA and LCT can result in human GB contraction and induce the release of only CCK-8. Continuous IV administration of AA and LCT for greater than 2h causes exhaustion of CCK-8 release, so that the GB returns to its initial volume.
Kalfarentzos
F
F
Department of Surgery, School of Medicine, University of Patras, Greece.
Vagenas
C
C
Michail
A
A
Vasilakos
P
P
Markoy
S
S
Kordossis
T
T
Androulakis
J
J
D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D002766:Cholecystokinin / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010289:Parenteral Nutrition, Total / Q000009:adverse effects; D012844:Sincalide / Q000378:metabolism; D014280:Triglycerides / Q000008:administration & dosage / Q000494:pharmacology*; D014463:Ultrasonography
D000596:Amino Acids; D004041:Dietary Fats; D014280:Triglycerides; D002766:Cholecystokinin; D012844:Sincalide