title: Interaction of glucose signals between the nucleus of the tractus solitarius and the portal vein area in the control of gastric acid secretion in rats.
abstract: Gastric acid outputs were examined after glucose injection into the nucleus of the tractus solitarius (SOL) of the medulla oblongata or into the portal vein (PV) or both using the bilaterally adrenalectomized rats. Twenty mM glucose (500 nl) injected into the SOL or into the PV (25 microliters) decreased the acid output associated with insulin-hypoglycemia. Simultaneous injection of glucose into the SOL and PV produced a reduction in acid output in a synergistic manner. It was also noted that a significant reduction in acid output was seen when an ineffective concentration of glucose was injected into the OSL and PV simultaneously. Results suggest that the SOL and PV signals interact with each other to potentiate the inhibition of gastric acid secretion.
authors.affiliation: Department of Physiology, Niigata University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sakaguchi
authors.forename: K
authors.initials: K
authors.lastname: Nakadaira
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D005744:Gastric Acid / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D011169:Portal Vein / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D005947:Glucose