title: Determination of cefsulodin, cefmenoxime, and cefadroxil as residues on surfaces.
abstract: Cefsulodin, cefmenoxime, and cefadroxil are degraded instantaneously in aqueous sodium hypochlorite, sodium hypochlorite-detergent, or alkaline detergent solutions. These alkaline solutions are used to clean surfaces that have been exposed to the cephalosporins. The cleaned surfaces are monitored for residual drug levels (microgram) using a wet swab-dry swab technique. After extraction from the swabs, the content of the respective cephalosporin is determined in the solution by high-performance liquid chromatography. The limit of detection for each of the compounds is 0.1 microgram/ml. Recoveries from nonporous surfaces ranged from 56 to 102%.
authors.affiliation: Analytical Research Department, Abbott Laboratories, North Chicago, Illinois 60064-4000.
authors.forename: R J
authors.initials: RJ
authors.lastname: Gorski
authors.forename: A C
authors.initials: AC
authors.lastname: Plasz
authors.forename: L
authors.initials: L
authors.lastname: Elrod
authors.forename: J
authors.initials: J
authors.lastname: Yoder
authors.forename: L B
authors.initials: LB
authors.lastname: White
mesh_terms: D002434:Cefadroxil / Q000032:analysis*; D015281:Cefmenoxime / Q000032:analysis*; D002441:Cefsulodin / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003902:Detergents; D004350:Drug Residues / Q000032:analysis; D011786:Quality Control
chemical_list: D003902:Detergents; D002434:Cefadroxil; D015281:Cefmenoxime; D002441:Cefsulodin