Detection of Cryptosporidium circulating antigens in human and calf sera.
Cryptosporidium-specific circulating antigens were detected in sera of experimentally infected calves and AIDS patients by an enzyme-linked immunosorbent assay. Antigenemia was detectable from 2 to a minimum of 22 days post-infection (d.p.i.) in calves whose feces were parasitologically positive from 2-10 d.p.i. Antigenemia was detected in AIDS patients showing no a sero-conversion to immunoglobulin (Ig) M or to IgG. The detection of circulating antigens in humans allows early diagnosis of cryptosporidiosis, even in immunosuppressed patients.
Gomez Morales
M A
MA
Laboratory of Parasitology, Istituto Superiore di Sanità, Rome, Italy.
Pozio
E
E
Croppo
G P
GP
D000818:Animals; D000953:Antigens, Protozoan / Q000097:blood* / Q000276:immunology; D002417:Cattle; D003457:Cryptosporidiosis / Q000150:complications / Q000276:immunology; D003458:Cryptosporidium / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006679:HIV Seropositivity / Q000150:complications / Q000276:immunology; D006801:Humans
D000953:Antigens, Protozoan