Chemically induced Parkinson's disease. III: A study of a possible role of singlet molecular oxygen in Parkinson's disease.
The near IR emission at 1270 nm following pulsed laser excitation of methylene blue in deuterium oxide, was used to study the interaction of a singlet molecular oxygen (1O2) with (i) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its oxidation products, and (ii) biosubstrates of relevance in Parkinson's disease. Steady state irradiation of methylene blue and MPTP led to a product with an absorption profile consistent with that of 1-methyl-4-phenyl-2,3-dihydropyridinium ion. This may suggest that even if monoamine oxidase enzyme activity is inhibited by the use of drugs such as Deprenyl and Paragyline the underlying conversion of MPTP to its neurotoxic oxidation product via 1O2 may still take place.
Chacón
J N
JN
Department of Chemistry and Chemical Engineering, Paisley College, U.K.
Truscott
T G
TG
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D007834:Lasers; D008995:Monoamine Oxidase; D010100:Oxygen / Q000737:chemistry*; D010293:Pargyline; D010300:Parkinson Disease / Q000209:etiology*; D011838:Radiation-Sensitizing Agents / Q000737:chemistry*; D012642:Selegiline
D005609:Free Radicals; D011838:Radiation-Sensitizing Agents; D012642:Selegiline; D010293:Pargyline; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D008995:Monoamine Oxidase; D010100:Oxygen