title: Liquid chromatography-mass spectrometry in metabolic research. I. Metabolites of benzbromarone in human plasma and urine.
abstract: Seven benzbromarone metabolites were identified in human plasma and urine by electron-impact mass spectrometry after semipreparative high-performance liquid chromatographic fractionation and/or by liquid chromatography-mass spectrometry using a thermospray interface. The major metabolite in plasma and urine was a hydroxybenzofuranoyl species; the 1-hydroxyethyl entity was identified as a minor metabolite. Five urinary metabolites occurred in trace amounts, all of them carrying OH and/or C = O groups in different positions. The hydroxybenzofuranoyl metabolite has often been mistaken for benzarone in previous studies.
authors.affiliation: Pharmakin GmbH, Ulm, Germany.
authors.forename: P J
authors.initials: PJ
authors.lastname: Arnold
authors.forename: R
authors.initials: R
authors.lastname: Guserle
authors.forename: V
authors.initials: V
authors.lastname: Luckow
authors.forename: R
authors.initials: R
authors.lastname: Hemmer
authors.forename: H
authors.initials: H
authors.lastname: Grote
mesh_terms: D001553:Benzbromarone / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D013058:Mass Spectrometry; D015394:Molecular Structure
chemical_list: D001553:Benzbromarone