[Efficacy of a theophylline retard preparation administered at 3 different intake times additionally to basic medication].
In this randomised crossover study in 26 outpatients with bronchial asthma the efficacy of a new once-daily theophylline formulation given in addition to a baseline medication was investigated; moreover, under steady state conditions, the effect of three evening intake times (6, 8 and 10 p.m.) on 24-hour pharmacokinetics and peak-expiratory flow profiles was evaluated. The theophylline dose had been individually titrated. The pharmacodynamic results show a marked improvement in 24-hour lung function data after adding theophylline to a drug therapy including inhalative anti-cholinergics in 50% of the treated outpatients. No significant differences between the pharmacokinetic characteristics and the 24-hour averages (mesors) of peak expiratory flow at the three different intake times 6, 8 and 10 p.m. were found; however, intake at 10 p.m. resulted in the highest nocturnal excess of serum theophylline concentrations and the highest peak expiratory flow during the early morning hours between 2 and 6 a.m.
Siebert
B
B
Rudolf-Virchow Universitätskliniken (Wedding), Abteilung für klinische Immunologie und Asthma-Poliklinik, Universitätsklinikum Charlottenburg, Berlin.
Kunkel
G
G
Borner
K
K
Staudinger
H W
HW
Böhm
A
A
Steinijans
V W
VW
D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000627:therapeutic use; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D013806:Theophylline / Q000008:administration & dosage*; D013997:Time Factors
D010276:Parasympatholytics; D013806:Theophylline
Wirksamkeit eines zu drei verschiedenen abendlichen Einnahmezeiten zusätzlich zu einer Basismedikation gegebenen Theophyllinretardpräparates.