title: Therapeutic effect of orally applied cytidine diphosphate choline in mild and severe degrees of normobaric and normocapnic degrees of hypoxia of rats.
abstract: Eighty Wistar rats were maintained under conditions of chronic hypoxic for a period of 5 months. After gradual adaptation to the reduced oxygen content of the inhaled air, animals were kept on the levels of 15, 12, 10 and 7 vol% O2 and their behaviour in an open field was observed. One group of 40 animals received CDP-choline (cytidine diphosphate choline, Somazina; CAS 1477-47-0) at a dose of 100 mg/kg body weight in their food. Hypoxia-induced behavioural deteriorations were partly mitigated by this substance. Therapeutic application of CDP-choline was more effective than prophylactic administration. The efficiency of CDP-choline decreased after prolonged application. Under conditions of extreme hypoxia CDP-choline exhibited a life prolonging effect.
authors.affiliation: Institute of Neuropathology, Free University of Berlin, Fed. Rep. of Germany.
authors.forename: G
authors.initials: G
authors.lastname: Hamdorf
authors.forename: J
authors.initials: J
authors.lastname: Cervós-Navarro
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001273:Atmosphere Exposure Chambers; D001274:Atmospheric Pressure; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000502:physiology; D002245:Carbon Dioxide / Q000378:metabolism; D002908:Chronic Disease; D003566:Cytidine Diphosphate Choline / Q000008:administration & dosage / Q000627:therapeutic use*; D003672:Defecation / Q000187:drug effects; D006120:Grooming / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002245:Carbon Dioxide; D003566:Cytidine Diphosphate Choline