Oxidative stress in ethanol intoxicated rats.
The present work has investigated the correlation between short-term ethanol administration and the free radicals production in rat liver. The non-protein-SH and lipid peroxides contents, superoxide dismutase and glutathione peroxidase activities were investigated. Increased lipid peroxides concentration, decreased glutathione content, significant increase in superoxide dismutase activity and a decrease in glutathione peroxidase activity were observed.
Dinu
V
V
Department of Biochemistry, Institute of Medicine and Pharmacy, Bucharest, Romania.
Zamfir
O
O
D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation / Q000502:physiology; D000431:Ethanol / Q000009:adverse effects / Q000493:pharmacokinetics*; D005609:Free Radicals / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000187:drug effects
D005609:Free Radicals; D000431:Ethanol; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione