[Dosage reduction of d-phe-6-GnRH for the regulation of ovulation by complexation with polyglycine].
The gonadotropin-releasing-hormone analogue D-Phe6-GnRH was complexed with polyglycine under non-denaturing conditions. The liberation behaviour of these complexes was investigated in vitro in dependence of hormone content. The "effective dose 50" (ED 50) could be decreased by factor 34 in vivo in mouse ovulation test by reason of protection effect of polyglycine for the hormone against untimely proteolytical degradation.
Naumann
W
W
Technische Universität Dresden, Institut für Lebensmittelchemie und technische Biochemie.
Braun
K
K
Losse
G
G
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D010060:Ovulation / Q000187:drug effects*; D010455:Peptides / Q000737:chemistry*
D010455:Peptides; C011080:polyglycine; D007987:Gonadotropin-Releasing Hormone
Dosisminderung von D-Phe6-GnRH bei der Ovulationsregulierung durch Komplexierung mit Polyglycin.