title: Ocular disposition of acetaminophen and its metabolites following intravenous administration in rabbits.
abstract: Time-courses of both 'total' (unchanged plus metabolized) and unmetabolized acetaminophen were investigated in plasma and ocular tissues of rabbit after intravenous administration. The drug freely diffuses across the haemato-ocular barriers, reaching eye levels equal to those in the plasma; ocular concentrations are higher than those of all other investigated drugs. The time-course in aqueous is superimposable to that observed in the plasma; in other ocular tissues it is much slower. There is evidence of an ocular metabolism or a concentration into the eye of minor metabolites formed elsewhere.
authors.affiliation: Institute of Pharmacology and Pharmacognosy, University of Rome, La Sapienza, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Romanelli
authors.forename: P
authors.initials: P
authors.lastname: Valeri
authors.forename: L A
authors.initials: LA
authors.lastname: Morrone
authors.forename: G
authors.initials: G
authors.lastname: Pimpinella
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000083:Acetanilides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000700:Analgesics / Q000493:pharmacokinetics*; D000818:Animals; D001769:Blood / Q000378:metabolism; D002555:Cerebrospinal Fluid / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D005965:Glucuronates / Q000378:metabolism; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits
chemical_list: D000083:Acetanilides; D000700:Analgesics; D005965:Glucuronates; D000082:Acetaminophen; C026137:3-hydroxyacetanilide