[The role of immunocytes in the production of interferon in response to its induction by aromatic hydrocarbons].
Interferon (IF) was synthesized in animals by diverse populations of immunocytes in response to induction by various low molecular weight aromatic hydrocarbons. The level of the involvement of either population of the immunocytes in IF production is determined by the chosen inductor. IF induction by acridanone L-1 was mainly observed in macrophages and B-lymphocytes. T-Cells actively participated in IF synthesis induced by amyxin, a representative of the fluorenone group. IF synthesized by lymphocytes of human peripheral blood in response to L-1 was completely neutralized by antiserum to alpha-IF while IF induced by amyxin in the same culture was a mixture of alpha- and beta-IFs at a ratio of 3:1.
Tazulakhova
E B
EB
Chizhov
N P
NP
Borisova
M S
MS
Ershov
F I
FI
D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D002417:Cattle; D003470:Culture Media; D066298:In Vitro Techniques; D007369:Interferon Inducers / Q000494:pharmacology*; D016898:Interferon-alpha / Q000096:biosynthesis*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008808:Mice, Inbred CBA; D008954:Models, Biological; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D013994:Tilorone / Q000494:pharmacology*
D000166:Acridines; D003470:Culture Media; D007369:Interferon Inducers; D016898:Interferon-alpha; D013994:Tilorone; C026430:10-carboxymethyl-9-acridanone
Uchastie immunotsitov v produktsii interferona v otvet na induktsiiu aromaticheskimi uglevodorodami.