title: Biosynthesis of glycophosphoinositol anchors in Saccharomyces cerevisiae.
abstract: Numerous membrane glycoproteins of Saccharomyces cerevisiae are posttranslationally modified by the addition of a glycophosphatidylinositol (GPI). These proteins can be detected most easily by metabolic labelling of yeast cells with 3H-myoinositol or 3H-palmitate. This report summarizes what little is known about the identity, biosynthesis and cellular localization of GPI-modified glycoproteins in Saccharomyces cerevisiae as well as what could be learned from the system with respect to the biosynthesis of GPI's in general.
authors.affiliation: Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Conzelmann
authors.forename: C
authors.initials: C
authors.lastname: Fankhauser
authors.forename: A
authors.initials: A
authors.lastname: Puoti
authors.forename: C
authors.initials: C
authors.lastname: Desponds
mesh_terms: D004591:Electrophoresis, Polyacrylamide Gel; D017261:Glycosylphosphatidylinositols; D008562:Membrane Glycoproteins / Q000737:chemistry*; D009154:Mutation; D010716:Phosphatidylinositols / Q000096:biosynthesis*; D011134:Polysaccharides / Q000096:biosynthesis*; D012441:Saccharomyces cerevisiae / Q000737:chemistry*
chemical_list: D017261:Glycosylphosphatidylinositols; D008562:Membrane Glycoproteins; D010716:Phosphatidylinositols; D011134:Polysaccharides