Research on heterocyclic compounds. XXVIII. Imidazo[1,2-c]pyrimidines.
A group of 24 imidazo[1,2-c]pyrimidines was taken into consideration in order to study their relationships between chemical structure and antiinflammatory activity. Some of these compounds were synthesized by us in the past, the others have been synthesized and characterized to complete the series. Antiinflammatory, analgesic, antipyretic and gastric ulcerogenic activities of such compounds were compared with those of indomethacin and discussed in terms of the effects exerted by the presence on the heterocyclic system of various substituents and an acidic or nonacidic moiety.
Abignente
E
E
Dipartimento di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Università di Napoli Federico II.
Arena
F
F
De Caprariis
P
P
Luraschi
E
E
Sacchi
A
A
Lampa
E
E
Berrino
L
L
Donnoli
D
D
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D002855:Chromatography, Thin Layer; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010147:Pain Measurement; D011247:Pregnancy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology; D013329:Structure-Activity Relationship
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001643:Bridged Bicyclo Compounds; D007093:Imidazoles; D011743:Pyrimidines; D002351:Carrageenan; D019342:Acetic Acid