Effects of geraniin on morphology and function of macrophages.
The effects of geraniin, a tannin, isolated from Geranium thunbergii Sieb. et Zucc. on the morphology and function of macrophages were studied. Geraniin caused a marked retardation of the recovery from fully spread surface membrane and a highly reorganized cytoskeleton of macrophages, whereas endocytotic activity, phagocytosis and pinocytosis in the cells were significantly inhibited.
Ushio
Y
Y
Research Institute of Oriental Medicine, Kinki University, Osaka, Japan.
Okuda
T
T
Abe
H
H
D008841:Actin Cytoskeleton / Q000648:ultrastructure; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D004705:Endocytosis / Q000187:drug effects; D005960:Glucosides / Q000494:pharmacology*; D047348:Hydrolyzable Tannins; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008855:Microscopy, Electron, Scanning; D008870:Microtubules / Q000648:ultrastructure; D010587:Phagocytosis / Q000187:drug effects; D010873:Pinocytosis / Q000187:drug effects; D013634:Tannins
D005960:Glucosides; D047348:Hydrolyzable Tannins; D013634:Tannins; C024603:Geraniin