Cross-conjugated and pseudo-cross-conjugated mesomeric betaines, XVIII: Bicyclic mesoionic pyrimidines with cardiovascular activity.
Reaction of alpha-Anilino-azines 1a-i with activated malonates (magic malonates) 2a-e leads to bicyclic mesoionic systems 3-7. Out of these, pyrimido[1,2-alpha]pyrimidines 3b,d are active as cardiotonics, whereas pyrimido[1,2-alpha]pyrimidines 4a-g show significant anti-anginal and anti-hypertensive activity.
Kappe
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Institute of Organic Chemistry, Karl-Franzens-University Graz, Austria.
Kappe
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D000818:Animals; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D051379:Mice; D011728:Pyridones / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D002317:Cardiovascular Agents; D011728:Pyridones