Sequence polymorphism of Amb a I and Amb a II, the major allergens in Ambrosia artemisiifolia (short ragweed).
Two of the major allergens in the pollen of short ragweed are Amb a I and Amb a II (formerly antigen E and antigen K, respectively). The genes for Amb a I and Amb a II have recently been cloned, and it was shown that Amb a I is a family of proteins with at least three distinct polymorphic family members. This study addresses the number of individual Amb a I and Amb a II family members, the polymorphism in each family member and the expression of these genes in ragweed plants from different geographical locations. This work led to the cloning and characterization of a fourth Amb a I family member, designated Amb a I.4.
Griffith
I J
IJ
ImmuLogic Pharmaceutical Corporation, Cambridge, Mass.
Pollock
J
J
Klapper
D G
DG
Rogers
B L
BL
Nault
A K
AK
D000485:Allergens / Q000737:chemistry* / Q000235:genetics*; D000595:Amino Acid Sequence; D052179:Antigens, Plant; D001483:Base Sequence; D008969:Molecular Sequence Data; D010936:Plant Extracts / Q000737:chemistry; D010940:Plant Proteins; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000032:analysis
D000485:Allergens; C026967:Amb a I protein, Ambrosia artemisiifolia; D052179:Antigens, Plant; D010936:Plant Extracts; D010940:Plant Proteins; D012333:RNA, Messenger; C074244:Amb a II protein, Ambrosia artemisiifolia