Whole blood granulocyte aggregation in vitro in dialysis-dependent patients.
Whole blood granulocyte aggregation in vitro was measured in 17 haemodialysis (HD) patients, 18 continuous ambulatory peritoneal dialysis (CAPD) patients, and 30 age-matched normal controls. Granulocyte aggregation was significantly increased in dialysis-dependent patients compared to controls (P less than 0.001) and was statistically significantly higher in CAPD patients compared to HD patients (P less than 0.01). [CAPD patients, median (range): 56.5 (44-71)%; HD patients: 53.0 (32-67)%; Controls; 42.5 (33-56)%.] Since granulocyte hyperaggregability has been linked with the pathogenesis of ischaemic vascular disease, abnormal granulocyte activity in dialysis-dependent patients may be of many factors contributing to their increased cardiovascular morbidity.
Taylor
J E
JE
Renal Unit, Ninewells Hospital and Medical School, Dundee, Scotland.
Bridges
A
A
Henderson
I S
IS
Stewart
W K
WK
Belch
J J
JJ
D000328:Adult; D000368:Aged; D002449:Cell Aggregation; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D010530:Peritoneal Dialysis; D006435:Renal Dialysis
D009240:N-Formylmethionine Leucyl-Phenylalanine