Effect of puberty on insulinlike growth factor I and HbA1 in type I diabetes.
OBJECTIVE
To assess the effect of puberty on the relationship between glycemic control and insulinlike growth factor I (IGF-I) levels in children with insulin-dependent (type I) diabetes mellitus.


METHODS
Simultaneous HbA1 and plasma IGF-I levels were determined in 71 prepubertal (Tanner stage I) and 112 pubertal (Tanner stages II-V) subjects aged 2.7-17.8 yr.


RESULTS
Overall, IGF-I levels were positively correlated with both age (r = 0.31, P less than 0.001) and Tanner stage (r = 0.32, P less than 0.001) but only weakly associated with HbA1 values (r = -0.16, P = 0.025). A strong negative association existed between IGF-I and HbA1 levels (r = -0.45, P less than 0.001) in the pubertal subjects, but no such association was apparent in the prepubertal subjects. Multiple regression analyses disclosed a significant independent negative association between IGF-I and HbA1 levels in the pubertal group (P less than 0.001) but not in the prepubertal group.


CONCLUSIONS
Glycemic control appears to strongly influence IGF-I levels only after the onset of puberty.
Rogers
D G
DG
Texas Children's Diabetes Center, Texas Children's Hospital.
Sherman
L D
LD
Gabbay
K H
KH
D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D011627:Puberty / Q000097:blood*; D012044:Regression Analysis; D012727:Sex Characteristics
D006442:Glycated Hemoglobin; D007334:Insulin-Like Growth Factor I