Developmental changes in expression of adhesion-mediating proteins in human aortic smooth muscle.
Phenotypic variability of vascular smooth muscle cells (SMCs) can serve as a good model for studying the mechanisms regulating the expression of adhesion-mediating proteins. To describe phenotypic changes of human aortic SMCs, we have studied the expression of cytodifferentiation-related adhesion-mediating proteins in samples of media from fetal, child and adult human aorta, and in subendothelial intima of normal and atherosclerotic aorta. We have shown that during prenatal and post-natal development vascular SMCs co-ordinately change several times the expression of certain differentiation-related proteins. Our data show the existence of certain groups of proteins whose expression during smooth muscle development might be controlled by two basic mechanisms: selection of genes to be expressed at particular developmental stages and generation of several different protein variants from a single gene via alternative RNA splicing.
Koteliansky
V E
VE
Institute of Experimental Cardiology, Academy of Medical Science, Moscow, U.S.S.R.
Belkin
A M
AM
Frid
M G
MG
Glukhova
M A
MA
D000328:Adult; D001011:Aorta / Q000254:growth & development / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005333:Fetus / Q000378:metabolism; D005353:Fibronectins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007223:Infant; D016023:Integrins / Q000235:genetics / Q000378:metabolism*; D024510:Muscle Development; D009131:Muscle, Smooth, Vascular / Q000254:growth & development / Q000378:metabolism*; D010641:Phenotype; D016596:Vinculin / Q000235:genetics / Q000378:metabolism*
D005353:Fibronectins; D016023:Integrins; D016596:Vinculin