Sucralfate in the prevention of acute gastric lesions induced by ischemia-reperfusion.
The role of Sucralfate in prevention of acute gastric injuries and its comparison with free radicals blockers as Allopurinol, Soybean Trypsin Inhibitor and Superoxide Dismutase was studied in the ischemia-reperfusion model by total occlusion of the celiac axis in Wistar rats. In control rats, the gross gastric mucosal necrotic area was of 80%; in contrast, the antioxidant drugs resulted in a necrotic area of 7%-15% and Sucralfate resulted in a necrotic area of only a 4%. It was concluded that Sucralfate, as antioxidant-cytoprotective drug, by enhancing the gastric defensive barrier was more important than the secondary aggression induced by free radicals.
Laudanno
O M
OM
Cathedra of Medical Pathology III (Gastroenterology), Faculty of Medicine, Rosario, Argentine.
Bedini
O A
OA
Cesolari
J A
JA
San Miguel
P
P
D000493:Allopurinol / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D009336:Necrosis; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000150:complications / Q000517:prevention & control*; D013392:Sucralfate / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000627:therapeutic use; D014360:Trypsin Inhibitor, Kunitz Soybean / Q000627:therapeutic use
D013392:Sucralfate; D000493:Allopurinol; D014360:Trypsin Inhibitor, Kunitz Soybean; D013482:Superoxide Dismutase