[Effects of phosphate therapy on parathyroid gland reactivity].
The effects of a single oral dose of phosphate (780 mg of elemental phosphorus as 100 drops of Phosphoneurol 120 from DOMS-Adrian Laboratories) on parathyroid function and on calcium and phosphate metabolism were studied in 10 young adults. The parathyroid response was checked by measurement of PTH 1-84 and of nephrogenous cAMP before and after a 10 days therapy by phosphate (780 mg of elemental phosphorus twice daily). Before treatment a 16 per cent increase in PTH 1-84 (p less than 0.05) and a 34 per cent increase in nephrogenous cAMP (p less than 0.02) was obtained. After treatment the increases were respectively 34 per cent for PTH 1-84 (p less than 0.001) and 67 per cent for nephrogenous cAMP (p less than 0.001). The responses in PTH 1-84 and in nephrogenous cAMP were significantly (p less than 0.05 and p less than 0.01) higher after than before treatment by phosphate.
Guillemant
J
J
Service de Biochimie, Faculté de Médecine Pitié-Salpêtrière, Paris.
de Chasteigner
C
C
Guillemant
S
S
D000328:Adult; D002118:Calcium / Q000097:blood / Q000652:urine; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood / Q000502:physiology*; D010710:Phosphates / Q000097:blood / Q000502:physiology / Q000627:therapeutic use* / Q000652:urine
D010281:Parathyroid Hormone; D010710:Phosphates; D002118:Calcium
Effets d'un traitement par le phosphate sur la réactivité parathyroïdienne.