Analyzing effects of vaccines.
A population with (individually) varying susceptibilities to infection and a vaccine with (individually) varying protective effect are considered. A simple stochastic model is used to illustrate different effects of the vaccine on the spread of the infection. The behavior of different estimators of the vaccine efficacy using data from a clinical trial and the relation between vaccine efficacy and the effectiveness of a vaccination program are discussed.
Svensson
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Stockholm University, Sweden.
D004196:Disease Outbreaks / Q000517:prevention & control; D006801:Humans; D017053:Infection Control; D008433:Mathematics; D008954:Models, Biological; D013269:Stochastic Processes; D014612:Vaccines / Q000494:pharmacology*
D014612:Vaccines