Action of oren-gedoku-to on platelet aggregation in vitro.
Oren-gedoku-to is a Chinese medicine with hypotensive activity, hemostatic actions and the ability to augment cerebral blood flow. It is therefore expected to be useful in patients with hypertension and cerebrovascular accident (CVA). These effects of Oren-gedoku-to on platelet aggregation and coagulation-fibrinolysis were evaluated. A significant decline in platelet aggregation rate in both healthy control and patient plasma in response to Oren-gedoku-to was found. Maximal platelet aggregation time shortened, however, in healthy controls, but was prolonged in 8 of 20 patients with CVA, in particular those with cerebral infarction.
Mori
M
M
Clinical Laboratory, Koshigaya Hospital, Dokkyo University School of Medicine, Tokyo, Japan.
Hojo
E
E
Takano
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D000979:alpha-2-Antiplasmin / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; D000979:alpha-2-Antiplasmin; D010958:Plasminogen