A new phloroglucinol derivative from Hypericum calycinum with antifungal and in vitro antimalarial activity.
The new phloroglucinol derivative 1 has been isolated from the light petroleum ether extract of the aerial parts of Hypericum calycinum. Its structure has been established by means of 1H- and 13C-NMR spectroscopy and by nOe, MHQC, and HMBC experiments on its monomethyl ether derivative 3. Compound 1 was fungicidal against Cladosporium cucumerinum in a TLC bioassay. In addition, this new phloroglucinol derivative was also found to exert an interesting antimalarial activity in an in vitro test system.
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Institut de Pharmacognosie et Phytochimie, Ecole de Pharmacie, Université de Lausanne, Switzerland.
Hoffmann
E
E
Kyburz
R
R
Bray
D
D
Hostettmann
K
K
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D001700:Biomphalaria / Q000187:drug effects; D002963:Cladosporium / Q000187:drug effects; D006801:Humans; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000935:Antifungal Agents; D000962:Antimalarials; D010696:Phloroglucinol