Use of Z-amino acid-glyceryl esters in protease catalyzed peptide synthesis.
The alpha-glyceryl esters of Z-Gly, Z-Phe and Z-Tyr were synthesized and their use for protease catalyzed peptide synthesis was studied. Three enzymes isolated from crude papain were compared in their catalytic potency. Syntheses with alpha-chymotrypsin were performed in a biphasic system.
Wiese
J
J
Deutsches Wollforschungsinstitut, Aachen, BRD.
Gattner
H G
HG
Zahn
H
H
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry; D010450:Endopeptidases / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D005990:Glycerol / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000737:chemistry
D000596:Amino Acids; D004151:Dipeptides; D004952:Esters; D010455:Peptides; C017105:carbobenzoxyphenylalanine; D010649:Phenylalanine; D010450:Endopeptidases; D005990:Glycerol