In vitro contraction test for malignant hyperthermia in patients with unexplained recurrent rhabdomyolysis.
A few cases of non-anaesthetic-induced rhabdomyolysis in humans, predisposed to malignant hyperthermia (MH), have been described in literature. We studied a group of 6 consecutive patients with unexplained and recurrent attacks of rhabdomyolysis with the test used to determine susceptibility to MH, the in vitro contraction test (IVCT). The results of the IVCT showed 5 of these 6 patients to be MH susceptible. In cultured muscle cells from one of these patients a disturbed calcium homeostasis could be demonstrated. The relation between MH and recurrent rhabdomyolysis is discussed.
Poels
P J
PJ
Institute of Neurology, University of Nijmegen, The Netherlands.
Joosten
E M
EM
Sengers
R C
RC
Stadhouders
A M
AM
Veerkamp
J H
JH
Benders
A A
AA
D000328:Adult; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D004198:Disease Susceptibility; D005260:Female; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D009119:Muscle Contraction; D009132:Muscles / Q000187:drug effects / Q000503:physiopathology* / Q000648:ultrastructure; D010375:Pedigree; D012206:Rhabdomyolysis / Q000473:pathology / Q000503:physiopathology*
D002110:Caffeine; D002118:Calcium; D006221:Halothane