[Therapeutic usefulness of antioxidant drugs in experimental intestinal reperfusion syndrome].
The intestinal reperfusion injury has been studied in Sprague-Dawley rats weighing 200 g. Intestinal ischemia has been induced by clamping the Superior Mesenteric Artery (SMA) for 120 minutes. In order to parallel clinical situations, free radical scavengers (allopurinol [ALLO]) and superoxide-dismutase [SOD] were inoculated at a low perfusion rate through the femoral vein during the last 20 minutes of the ischemic period. Both drugs have decreased the mortality rate (from 70% in control group, to 40%) and the mean percentage of damaged intestine (30.89% vs. 23.84% and 24.70%). Histologically, ALLO was less effective than SOD (12.54 control; 8.40 SOD; 11.54 ALLO). The modification of glucose, SGOT, SGPT and LDH found in all the ischemic animals shows the hepatocellular injury induced by intestinal reperfusion.
Bilbao
J
J
Hospital de Basurto, Departamento de Cirugía, Universidad del País Vasco.
García-Alonso
I
I
Portugal
V
V
Barceló
P
P
Ortiz
J
J
Méndez
J
J
D000493:Allopurinol / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D005260:Female; D016166:Free Radical Scavengers; D008111:Liver Function Tests; D008638:Mesenteric Arteries; D008641:Mesenteric Vascular Occlusion / Q000150:complications*; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000627:therapeutic use*
D000975:Antioxidants; D016166:Free Radical Scavengers; D000493:Allopurinol; D013482:Superoxide Dismutase
Utilidad terapéutica de fármacos antioxidantes en el síndrome de reperfusión intestinal experimental.