Modification of a cylindrical bidomain model for cardiac tissue.
Previous models based on a cylindrical bidomain assumed either that the ratio of intracellular and interstitial conductivities in the principal directions were the same or that there was no radial variation in potential (i.e., a planar front, delta Vm/delta rho = 0). This paper presents a formulation and the expressions for the intracellular, interstitial, extracellular, and transmembrane potentials arising from nonplanar propagation along a cylindrical bundle of cardiac tissue represented as a bidomain with arbitrary anisotropy. For unequal anisotropy, the transmembrane current depends not only on the local change of the transmembrane potential but also on the nature of the transmembrane potential throughout the volume.
Trayanova
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National Science Foundation-Engineering Research Center, Duke University, Durham, North Carolina 27706.
Henriquez
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CS
D000818:Animals; D006321:Heart / Q000502:physiology*; D006801:Humans; D008433:Mathematics; D008564:Membrane Potentials; D008955:Models, Cardiovascular