title: [Studies on diagnostic and prognostic validity of aminophenazone breath test in liver cirrhosis].
abstract: In 59 patients with liver cirrhosis (23 female, 36 male; aged between 30 and 73 years) the aminophenazone breath-test according to the Haustein-Schenker modification was performed. The results were related to morphological, clinical and haemodynamic criteria. In contrast to a control group, consisting of 8 women and 8 men aged between 23 and 27 years with healthy livers, the aminophenazone elimination proved to be heavily delayed (p less than 0.001). In consideration of the Havanna-classification the 14CO2-elimination was most heavily retarded in patients with portal cirrhosis, but compared with non-portal cirrhosis, the difference was below significance level. A significant dependence on the clinical degree of severity was found. The aminophenazone-elimination was frequently low in portal hypertension and considerably decreased after portocaval shunt with values below 200 DPM/mmol CO2/70 kg body weight. In some cases it could be demonstrated, that the test is not only of diagnostic relevance, but reflects the progression of cirrhosis.
authors.affiliation: Poliklinik für Innere Medizin, Medizinischen Akademie Erfurt.
authors.forename: H
authors.initials: H
authors.lastname: Sensing
authors.forename: J
authors.initials: J
authors.lastname: Treutler
authors.forename: K O
authors.initials: KO
authors.lastname: Haustein
authors.forename: G
authors.initials: G
authors.lastname: Hüller
mesh_terms: D000328:Adult; D000368:Aged; D000632:Aminopyrine / Q000032:analysis*; D001944:Breath Tests; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis; D008103:Liver Cirrhosis / Q000175:diagnosis*; D008104:Liver Cirrhosis, Alcoholic / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011167:Portacaval Shunt, Surgical; D011379:Prognosis
chemical_list: D000632:Aminopyrine
vernacular_title: Untersuchungen der diagnostischen und prognostischen Wertigkeit des Aminophenazon-Atemtestes bei Leberzirrhose.