Effects of some lipophilic carboxylic acid on release of interferon gamma from the human peripheral blood leukocytes.
Lipophilic carboxylic acids and their salts were tested for the ability of interferon induction in the cultures of human peripheral blood leukocytes. Of 13 tested organic compounds, two were selected: decyl-malonic acid and sodium salt of octylmethane-tri-(2-oxabutanoic)acid--which stimulated the synthesis of low amounts of gamma interferon.
Zielińska-Jenczylik
J
J
Laboratory of Virology, Polish Academy of Sciences, Wrocław.
Inglot
A D
AD
Piasecki
E
E
Sypuła
A
A
Albin
M
M
Młochowski
J
J
Skarzewski
J
J
D002264:Carboxylic Acids / Q000737:chemistry / Q000494:pharmacology*; D004987:Ethers / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007369:Interferon Inducers / Q000494:pharmacology; D007371:Interferon-gamma / Q000378:metabolism*; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology; D008314:Malonates / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014233:Tricarboxylic Acids / Q000494:pharmacology
D002264:Carboxylic Acids; D004987:Ethers; D007369:Interferon Inducers; D008314:Malonates; D014233:Tricarboxylic Acids; C073782:octylmethane-tri-(2-oxabutanoic acid); C073783:decylmalonic acid; D007371:Interferon-gamma