[Hemodynamic response of patients with arterial hypertension to graded pedal isometric exercise after administration of vasodilators of different classes].
Graded isometric exercise (IE) testing was performed to study the effects of vasodilators from various classes on the hemodynamic response in 60 patients with mild and moderate essential hypertension (EH). Hemodynamic parameters were determined by rheography. Group I patients took captopril, 50 mg, Group II prazosin, 2 mg, and Group III nifedipine, 20 mg. Hemodynamic changes tended to deteriorate in patients with the EH syndrome during IET. Application of the vasodilators led to the alleviation of the changes both at rest and during IET, as manifested by lower absolute values of the parameters and their relative increase. The beneficial influences of drugs from various classes on some hemodynamic parameters were different.
Ziiaev
Iu N
IuN
Nikitin
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Shakha
G Sh
GSh
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000145:classification / Q000627:therapeutic use; D002216:Captopril / Q000627:therapeutic use*; D004341:Drug Evaluation; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D011224:Prazosin / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000145:classification / Q000627:therapeutic use
D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D002216:Captopril; D009543:Nifedipine; D011224:Prazosin
Gemodinamicheskiĭ otvet bol'nykh s arterial'noĭ gipertenzieĭ na dozirovannuiu nozhnuiu izometricheskuiu nagruzku pod vliianiem vazodilatatorov razlichnykh klassov.