title: Longterm follow-up of onchocerciasis patients in Latin America after treatment and retreatment with amocarzine. Preliminary results.
abstract: Amocarzine has been reported to have onchocercacidal effects. Four months posttherapy the majority of adult worms were dead or moribund. The effect of skin microfilariae lasted up to one year as reflected by markedly reduced microfilaridermia. Since the duration of the onchocercacidal effect of amocarzine beyond one year was unknown and since such an effect may influence the planning of future control strategies, efforts were made to follow-up the already treated amocarzine patients for a second year. The present study from Latin America showed that various amocarzine drug regimens produced a prolonged reduction of microfilaridermia at the end of the second year following the initial therapy, the best levels were about 7-17% of the initial parasite load in the skin for some three days amocarzine regimens. Such an effect occurring in a transmission area of onchocerciasis in Latin America provides additional, although indirect, evidence of a macrofilaricidal effect of amocarzine. Similar experiences of a prolonged amocarzine effect on skin microfilariae has also been observed in West Africa (Ghana, Mali). Preliminary results of retreatment schedules at the start of the third year post-initial therapy showed that simplified postprandial dose regimen of one or two days were well tolerated. It is premature at the time of this report to judge upon their ultimate efficacy, but they had significantly reduced levels of moderate microfilaridermia.
authors.affiliation: CIBA-GEIGY Limited, Basle, Switzerland.
authors.forename: A A
authors.initials: AA
authors.lastname: Poltera
authors.forename: G
authors.initials: G
authors.lastname: Zea-Flores
authors.forename: R
authors.initials: R
authors.lastname: Guderian
authors.forename: H P
authors.initials: HP
authors.lastname: Striebel
authors.forename: M
authors.initials: M
authors.lastname: Moran
mesh_terms: D000818:Animals; D004484:Ecuador; D005369:Filaricides / Q000494:pharmacology / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006166:Guatemala; D006801:Humans; D008842:Microfilariae / Q000187:drug effects; D009854:Onchocerca / Q000187:drug effects*; D009855:Onchocerciasis / Q000188:drug therapy*; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D012867:Skin / Q000469:parasitology*
chemical_list: D005369:Filaricides; D010879:Piperazines; C051744:amocarzine