Platelet aggregation and fatty acid composition of platelets in type 1 diabetes mellitus.
A raised content of arachidonic acid in platelets from diabetic patients with retinopathy was found without differences in platelet aggregation: platelet aggregability was not related to platelet fatty acid composition. In diabetes, platelet aggregation was inversely correlated to non-esterified fatty acids in plasma and may suggest an inhibiting effect. Mean platelet volume was raised in the diabetic patients, but without hyperaggregability. The findings do not exclude a relationship between platelet fatty acids and platelet aggregability, but suggest that variations in levels of non-esterified fatty acids in plasma might interfere with platelet aggregation.
Myrup
B
B
Department of Medical Endocrinology, Frederiksberg Hospital, Denmark.
Bregengaard
C
C
Petersen
L R
LR
Winther
K
K
D000328:Adult; D000368:Aged; D016718:Arachidonic Acid / Q000097:blood; D001792:Blood Platelets / Q000737:chemistry* / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood; D005227:Fatty Acids / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D016718:Arachidonic Acid