Effect of clenbuterol on contractile response in periurethral striated muscle of rabbits.
The effect of clenbuterol, a selective beta 2-adrenoceptor agonist, on isolated periurethral striated muscle preparations from rabbits has been investigated. The periurethral striated muscle produced a contraction in response to field stimulation. An application of clenbuterol resulted in a dose-dependent potentiation of the field stimulation-induced contraction. This potentiation was antagonized by propranolol and was greater than that of isoproterenol, suggesting a beta 2-agonistic action.
Kishimoto
T
T
Pharmacological Research Department, Teijin Institute for Bio-Medical Research II, Tokyo.
Morita
T
T
Okamiya
Y
Y
Hoshina
K
K
Takeshita
T
T
D000818:Animals; D002976:Clenbuterol / Q000494:pharmacology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D014521:Urethra / Q000187:drug effects* / Q000502:physiology
D011433:Propranolol; D007545:Isoproterenol; D002976:Clenbuterol