title: The effect of vitamin E on granulocyte function in patients with recurrent infections.
abstract: The influence of vit. E treatment on metabolic and bactericidal granulocyte activity in patients with recurrent infections was studied by chemiluminescence and phagocytosis assays. Vit. E serum level was significantly diminished before therapy. Six weeks supplementation with 200-300 mg/day of vit. E resulted in improvement of clinical status and normalisation of alpha-tocopherol serum level. Bactericidal activity of granulocytes was lower in patients than in the respective controls and it slightly rose after vit. E therapy. Before, therapy, patients granulocytes showed metabolic activity above or within the control range. Vit. E treatment increased, had no effect or decreased granulocyte metabolic activity, but never below the control range.
authors.affiliation: Medical Center of Postgraduate Education, Warsaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Małkowska-Zwierz
authors.forename: P
authors.initials: P
authors.lastname: Garliński
authors.forename: M
authors.initials: M
authors.lastname: Zukowska
authors.forename: K
authors.initials: K
authors.lastname: Zabuska
authors.forename: M
authors.initials: M
authors.lastname: Wartanowicz
authors.forename: D
authors.initials: D
authors.lastname: Kleniewska
authors.forename: H
authors.initials: H
authors.lastname: Niemirowska
authors.forename: Z
authors.initials: Z
authors.lastname: Izdebska
authors.forename: W
authors.initials: W
authors.lastname: Roszkowski
authors.forename: T
authors.initials: T
authors.lastname: Wróblewski
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D001770:Blood Bactericidal Activity / Q000187:drug effects; D005260:Female; D005609:Free Radicals; D006098:Granulocytes / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D012008:Recurrence; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000150:complications / Q000503:physiopathology
chemical_list: D005609:Free Radicals; D014810:Vitamin E; D010100:Oxygen