title: [Hyposplenism in celiac disease. Role of a gluten-free diet].
abstract: Hyposplenism is a common complication of adult celiac disease. A study of splenic function in 17 adult patients with celiac disease was performed both before and during treatment with a gluten-free diet. Splenic hypofunction was assessed evaluating morphological changes in red cells (Howell-Jolly bodies, spherocytosis, achantocytosis). The hyposplenic changes were compared with: age of patients, duration of symptoms previous to diagnosis, severity of the clinical picture and histological response to treatment. We concluded that 82.4% of patients had hyposplenic changes and that there was a non significant tendency to improve such changes by a strict adherence to gluten-free diet.
authors.affiliation: Sección Intestino Delgado, Hospital Nacional de Gastroenterología, Buenos Aires, Argentina.
authors.forename: H
authors.initials: H
authors.lastname: Vázquez
authors.forename: C
authors.initials: C
authors.lastname: Martínez
authors.forename: L
authors.initials: L
authors.lastname: Xavier
authors.forename: R
authors.initials: R
authors.lastname: Mazure
authors.forename: L
authors.initials: L
authors.lastname: Boerr
authors.forename: J
authors.initials: J
authors.lastname: Bai
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002446:Celiac Disease / Q000097:blood / Q000150:complications* / Q000178:diet therapy; D002648:Child; D004912:Erythrocytes / Q000473:pathology; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D013158:Splenic Diseases / Q000097:blood / Q000209:etiology*
chemical_list: D005983:Glutens
vernacular_title: Hipoesplenia en la enfermedad celíaca. Rol de la dieta libre de glúten.