Changes in calcium homoeostasis and bone formation in patients recovering from acute myocardial infarction: effect of verapamil treatment. Danish Study Group on Verapamil in Myocardial Infarction.
The effect of the calcium antagonist verapamil on calcium homoeostasis and bone metabolism has been investigated in a double-blind randomized placebo-controlled study. Ten patients randomized to verapamil 120 mg t.i.d. and 9 patients randomized to placebo in The Danish Verapamil Infarction Trial II took part in the study. Bone formation, estimated by 24-h whole body retention of diphosphonate (WBR), osteocalcin, alkaline phosphatase and calcium metabolic indices, was recorded before the start of medication and after 1 and 6 months of treatment. Baseline calcium metabolic variables were not significantly different between the two study groups. There were no significant differences in WBR (0.38 vs 0.37), osteocalcin level (8.2 vs 8.0 micrograms/l) or alkaline phosphatase (218 vs 200 U/l) after treatment for 6 months with verapamil compared to placebo. Serum PTH, calcium and phosphate levels were also not affected by verapamil. The results suggest that prolonged treatment with clinical doses of verapamil does not affect indices of calcium and bone metabolism in humans.
Boesgaard
S
S
Department of Internal Medicine and Endocrinology, Herlev Hospital, University of Copenhagen, Denmark.
Hyldstrup
L
L
Feldstedt
M
M
D000469:Alkaline Phosphatase / Q000378:metabolism; D016723:Bone Remodeling / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism*; D003718:Denmark; D004164:Diphosphonates / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism*; D015675:Osteocalcin / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism; D014700:Verapamil / Q000494:pharmacology*
D004164:Diphosphonates; D010281:Parathyroid Hormone; D015675:Osteocalcin; D014700:Verapamil; D000469:Alkaline Phosphatase; D002118:Calcium