Attenuation of the pressor response to tracheal intubation in hypertensive proteinuric pregnant patients by lignocaine, alfentanil and magnesium sulphate.
The pressor response to intubation is known to be exaggerated in patients with gestational proteinuric hypertension (GPH). The effect of pretreatment with lignocaine 1.5 mg kg-1, magnesium sulphate 40 mg kg-1 or alfentanil 10 micrograms kg-1 on this pressor response was studied in 69 patients with moderate to severe GPH. Systolic arterial pressure exceeded baseline values for the first 5 min after tracheal intubation in the lignocaine group, with a peak increase of 31.6 (SEM 3.6) mm Hg at 2 min after intubation, but no mean increase in pressure occurred in the two other groups. Following intubation, six of 24 mothers in the alfentanil group, six of 21 in the lignocaine group and one of 24 in the magnesium group (P less than 0.05) exhibited a systolic arterial pressure (SAP) greater than 180 mm Hg sustained for 2 min or more. Alfentanil caused the least change in heart rate, but resulted in significant fetal depression.
Allen
R W
RW
Department of Anaesthesia, University of Cape Town, Medical School, Observatory, South Africa.
James
M F
MF
Uys
P C
PC
D015760:Alfentanil / Q000627:therapeutic use*; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008012:Lidocaine / Q000627:therapeutic use*; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000503:physiopathology / Q000601:surgery*; D011247:Pregnancy; D011897:Random Allocation; D013312:Stress, Physiological / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology
D015760:Alfentanil; D008278:Magnesium Sulfate; D008012:Lidocaine