[Radiosensitizing effects of Lycium barbarum polysaccharide for Lewis lung cancer].
The radiosensitizing effects of the Lycium barbarum polysaccharide (LBP) were observed by the model transplanted Lewis lung cancer on C57 BL mice. When LBP alone was administered, it was not obvious that LBP inhibited the growth of Lewis lung cancer. The significant radiosensitizing effects were obtained by combination of LBP and radiation. The mean numerical value of the dose modifying factors (DMF) was 2.05. The results also showed certain radiation enhancement effects of LBP to acute hypoxic cells of Lewis lung cancer. LBP presented few toxicity to the mice.
Lu
C X
CX
Cancer Institute, Ningxia Medical College, Yinchuan.
Cheng
B Q
BQ
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000532:radiotherapy*; D011134:Polysaccharides / Q000627:therapeutic use*; D011836:Radiation Tolerance / Q000187:drug effects; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; D011838:Radiation-Sensitizing Agents