[Interactions of fluconazole and phagocytic cells].
Fluconazole is a triazole compound with a coefficient of distribution P at pH 7.4 of 1.6 (log P = 0.2), and has thus both hydrophilic and lipophilic properties. The physicochemical and pharmacokinetic profiles of fluconazole are clearly different from those of other azole antimycotics. 3H-labelled fluconazole penetrates very rapidly into granulocytes and monocytes (macrophages) isolated from volunteers. The concentrations of the triazole in the granulocytes are about 28% and in the macrophages about 63% higher than in the extracellular milieu. At the concentrations examined (5, 10 and 20 micrograms ml-1) fluconazole damages cells of Candida albicans which have been phagocytized by granulocytes or by macrophages. A clear synergy between fluconazole and the phagocytes can be demonstrated.
Wildfeuer
A
A
Abteilung für Pathologie, Fakultät für Theoretische Medizin, Universität Ulm.
Laufen
H
H
Haferkamp
O
O
D002176:Candida albicans / Q000187:drug effects* / Q000276:immunology; D002478:Cells, Cultured; D015725:Fluconazole / Q000493:pharmacokinetics / Q000494:pharmacology*; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D009000:Monocytes / Q000378:metabolism*; D010586:Phagocytes / Q000378:metabolism*
D015725:Fluconazole
Wechselwirkungen von Fluconazol und phagozytierenden Zellen.