title: Human umbilical cord as a possible source of progesterone.
abstract: Homogenates of human term umbilical cord were incubated with 7n-3H-pregnenolone. Using a reverse-isotope dilution technique, 3H-progesterone was isolated and characterized. The extent of enzymic conversion ranged from 2.5 to 55.4%. The results indicate that the cord can be a source of progesterone during human pregnancy.
authors.affiliation: Institute of Science and Forensic Medicine, National Blood Centre, Singapore.
authors.forename: R
authors.initials: R
authors.lastname: Gunasegaram
authors.forename: K L
authors.initials: KL
authors.lastname: Peh
authors.forename: A
authors.initials: A
authors.lastname: Loganath
authors.forename: P C
authors.initials: PC
authors.lastname: Chew
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D000328:Adult; D003460:Crystallization; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011284:Pregnenolone / Q000737:chemistry / Q000502:physiology; D011374:Progesterone / Q000096:biosynthesis* / Q000502:physiology; D014470:Umbilical Cord / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology
chemical_list: D011374:Progesterone; D011284:Pregnenolone