Effect of dietary protein restriction on proteinuria in non-insulin-dependent diabetic patients with nephropathy.
To determine the effectiveness of dietary protein restriction on proteinuria in patients with non-insulin dependent diabetes (NIDDM), 14 diabetic patients with overt nephropathy were placed on either a low protein diet (N = 7) or conventional protein diet (N = 7) for one month. After the study period, daily urinary protein excretion rates decreased significantly, from 3.2 +/- 0.4 to 1.9 +/- 0.4 g/day, and serum albumin levels increased from 3.3 +/- 0.2 to 3.7 +/- 0.5 g/dl only in the low protein diet group, without any significant changes in either serum creatinine levels or creatinine clearance. These findings suggest that dietary protein restriction has a beneficial role in the treatment of NIDDM patients with overt nephropathy.
Sugimoto
T
T
Third Department of Medicine, Shiga University of Medical Science, Otsu, Japan.
Kikkawa
R
R
Haneda
M
M
Shigeta
Y
Y
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D003404:Creatinine / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy*; D003928:Diabetic Nephropathies / Q000178:diet therapy*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000178:diet therapy*; D012709:Serum Albumin / Q000032:analysis
D004044:Dietary Proteins; D012709:Serum Albumin; D003404:Creatinine