title: A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit.
abstract: We report a case of IgM-associated mesangial proliferative glomerulonephritis with microscopic hematuria and renal tubular dysfunction. On electron microscopy, a giant spherical deposit was observed in the glomerular paramesangial area. Deposition of C3 in the glomerular mesangial areas was not observed by immunofluorescence. IgM-associated mesangial proliferative glomerulonephritis is clinically characterized by nephrotic syndrome, mild proteinuria and/or hematuria, tubular dysfunction or renal failure, suggesting that it is considered to be a heterogeneous disorder.
authors.affiliation: Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Inokuchi
authors.forename: M
authors.initials: M
authors.lastname: Yokomatsu
authors.forename: K
authors.initials: K
authors.lastname: Funabiki
authors.forename: I
authors.initials: I
authors.lastname: Shirato
authors.forename: S
authors.initials: S
authors.lastname: Nakayama
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Tomino
authors.forename: H
authors.initials: H
authors.lastname: Koide
mesh_terms: D005260:Female; D005920:Glomerular Mesangium / Q000648:ultrastructure; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M; D008854:Microscopy, Electron; D008875:Middle Aged
chemical_list: D007075:Immunoglobulin M