title: [Pyruvic acid in the rat liver and myocardium after acute chlorfenvinphos poisoning].
abstract: The authors studied the effect of chlorfenvinphos on the pyruvic acid level in the liver and cardiac muscle of male Wistar rats. The animals were intoxicated with chlorfenvinphos in a single oral dose of 5 mg/kg (0.5 LD50). The pyruvate was assayed spectrophotometrically after 2, 4 and 24 hours following administration of the insecticide. The results obtained indicate that after intoxication with chlorfenvinphos there are no changes in the pyruvic acid level in the liver, but in the heart muscle, two hours after administration of insecticide, a significant decrease of this keto acid was observed. No alterations were found 4 and 24 hours after intoxication with chlorfenvinphos.
authors.affiliation: Katedry i Zakładu Chemii Toksykologicznej Akademii Medycznej w Lublinie.
authors.forename: S
authors.initials: S
authors.lastname: Szczepaniak
authors.forename: H
authors.initials: H
authors.lastname: Nowiński
authors.forename: K
authors.initials: K
authors.lastname: Jeleniewicz
authors.forename: H
authors.initials: H
authors.lastname: Maciejewska-Kozak
mesh_terms: D000208:Acute Disease; D000818:Animals; D002709:Chlorfenvinphos / Q000506:poisoning*; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011773:Pyruvates / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D011773:Pyruvates; D019289:Pyruvic Acid; D002709:Chlorfenvinphos
vernacular_title: Kwas pirogronowy w watrobie i sercu szczura w warunkach ostrej intoksykacji chlorfenwinfosem.