[The effect of plasmapheresis on the clinical and laboratory parameters of patients with idiopathic thrombocytopenic purpura].
It is shown that plasmapheresis (PA) as an adjuvant modality in combined treatment of idiopathic purpura resistant to glucocorticosteroids helps to partially overcome resistance and induces a positive trend in the clinical and hematological indices. Pretreatment number of glucocorticoid receptors in lymphocytes and the androgenic cortisol level in patients resistant to glucocorticosteroids were significantly lowered and rose after a course of therapeutic plasmapheresis. A PA positive effect is attributed to elimination from the vascular bed of circulating immune complexes, mid-mass molecules as well as raising the blockade of lymphocytic membranes.
Kerimov
A A
AA
Kalinichenko
L G
LG
Guseĭnov
T N
TN
Babaeva
L I
LI
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000503:physiopathology / Q000628:therapy*; D011965:Receptors, Glucocorticoid
D011965:Receptors, Glucocorticoid
Vliianie plazmafereza na kliniko-laboratornye pokazateli u bol'nykh idiopaticheskoĭ trombotsitopenicheskoĭ purpuroĭ.