title: [Participation of the adenylate cyclase system in the postsynaptic mechanism of heterosynaptic facilitation].
abstract: Changes in the EPSC and Ach-current amplitudes of Planorbis corneus LC-1 and RC-1 neurons has been comparatively investigated after the influence on their adenylate cyclase system in order to reveal postsynaptic mechanisms of the heterosynaptic facilitation. Both responses are n-cholinergic and depend on the membrane conductivity for Na+ and K+. Application of 5-HT has led to an increase of the EPSC and ACh current (in most cases) amplitudes by 100-300%. A negligible increase of the EPSC and at the same time a decrease of the Ach-current were observed in 30% of cells. It was, probably, a result of different contribution made by Na+ and K+ to the activation mechanism of the channel-receptor complex conductivity of the nonsynaptic cell membrane. Effects of 5-HT on EPSCs and Ach-current were imitated by actions of the phosphodiesterase blockers and adenylate cyclase activators. Both the blockers and activators depressed the EPSCs and Ach-current. Thus, activation of the adenylate cyclase system by serotonin has promoted development of the postsynaptic mechanisms of heterosynaptic facilitation in command neurons of Planorbis corneus.
authors.forename: V M
authors.initials: VM
authors.lastname: Storozhuk
authors.forename: I N
authors.initials: IN
authors.lastname: Antonov
authors.forename: O N
authors.initials: ON
authors.lastname: Osipenko
mesh_terms: D000109:Acetylcholine / Q000502:physiology*; D000262:Adenylyl Cyclases / Q000502:physiology*; D000818:Animals; D005071:Evoked Potentials / Q000502:physiology; D008974:Mollusca / Q000201:enzymology; D013569:Synapses / Q000201:enzymology*
chemical_list: D000262:Adenylyl Cyclases; D000109:Acetylcholine
vernacular_title: Uchastie adenilattsiklaznoĭ sistemy v postsinapticheskom mekhanizme geterosinapticheskogo oblegcheniia.