title: [Environmental monitoring and biological monitoring of young people exposed to nonoccupational levels of formaldehyde, toluene and other hydrocarbons].
abstract: During the period of 1983-1985, in two of apprentice schools of P. town the health disorders were investigated in the total of 82 apprentices 15-18 years old from the environment with elevated concentrations of formaldehyde and toluene. The study was contrasted with a control total of 42 apprentices. Cytogenetical examination has been performed, and selected immunological parameters in both blood serum and saliva have been assessed with red and white blood cells counts including differential formula of white blood cells. In addition, the atmospheric toxicity of formaldehyde and vapours of organic solvents (toluene, xylene, varnish naphtha) was measured. A single biological exposure test has been performed for the detection toluene. Statistically significant were differences in occurrence of cell chromosomal aberrations between the group of long term formaldehyde and toluene exposure (averagely 3.53% ABB) and controls (2.21% ABB) as obtained in 1983 and 1984, and so were differences between the long term-to-toluene exposed group (3.30% ABB) and the above mentioned control group as obtained in 1984. No similar results were stated between the long term-to-formaldehyde exposed (3.07% ABB) and control (2.55% ABB) groups in 1985. The main evidence consisted in finding the genotoxical/clastogenic effect of observed agents associated with mainly chromosomal abnormalities of chromatide type. It outflowed from the determination of selected serum proteins (Ig and acute phase proteins) and salivary lysozyme that the group under the combined influence of formaldehyde and toluene showed significantly lower IgG and higher alpha-1-antitrypsin (A1AT). The group at risk of toluene was characteristical in elevated concentrations of alpha-2-macroglobulin (A2M) and A1AT. Most pronounced changes in first year had been revealed through the evaluation of the influence of the duration at risk (significant decrease in IgA and prealbumin, and the increase in A2M and A1AT). The infectious disease as experienced 2 month prior the collection resulted in a significant decrease of IgM, A2M and A1AT in risky groups in individuals with infection in anamnesis. Salivary lysozyme concentration of apprentice environmentally exposed to formaldehyde in the noon showed the decrease, whereas its increase occurred in controls with the difference on 5% significancy level. Blood count assessements showed no significant differences between the investigated values as well as any were assessed between the incidence of health disorders of apprentices and their correspondance to the given group.
authors.affiliation: Krajská hygienická stanice, Hradec Králové.
authors.forename: H
authors.initials: H
authors.lastname: Vozenílková
authors.forename: M
authors.initials: M
authors.lastname: Tmĕjová
authors.forename: V
authors.initials: V
authors.lastname: Srb
authors.forename: E
authors.initials: E
authors.lastname: Kubzová
authors.forename: P
authors.initials: P
authors.lastname: Rössner
authors.forename: H
authors.initials: H
authors.lastname: Pohlovä
authors.forename: Z
authors.initials: Z
authors.lastname: Zudová
authors.forename: J
authors.initials: J
authors.lastname: Polák
authors.forename: V
authors.initials: V
authors.lastname: Chýlková
authors.forename: M
authors.initials: M
authors.lastname: Turková
mesh_terms: D000293:Adolescent; D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000032:analysis; D001772:Blood Cell Count; D001798:Blood Proteins / Q000032:analysis; D002869:Chromosome Aberrations; D004784:Environmental Monitoring; D005557:Formaldehyde / Q000009:adverse effects* / Q000032:analysis; D006801:Humans; D008297:Male; D012997:Solvents / Q000009:adverse effects* / Q000032:analysis; D014050:Toluene / Q000009:adverse effects* / Q000032:analysis
chemical_list: D000395:Air Pollutants, Occupational; D001798:Blood Proteins; D012997:Solvents; D005557:Formaldehyde; D014050:Toluene
vernacular_title: Monitorování prostredí a biologické monitorování mladistvých, neprofesionálnĕ exponovaných nízkým koncentracím formaldehydu, toluenu a jiných uhlovodíkû.