Metoclopramide increases plasma but not cerebrospinal fluid vasopressin levels in man: study in hydrocephalic patients.
Arginine vasopressin (AVP) concentrations were determined in plasma and in cerebrospinal fluid (CSF) in 8 adult male patients suffering from hydrocephalus of various etiologies, before and after intravenous administration of 10 mg metoclopramide. Metoclopramide was able to increase the plasma (2.6 +/- 0.2 ng/l in basal conditions and 6.1 +/- 0.6 ng/l at 30 min) but not the CSF AVP levels. The results suggest that the neurons which secrete AVP into the CSF may be functionally different from those secreting into the peripheral circulation.
Barreca
T
T
Department of Internal Medicine, University of Genoa, Italy.
Franceschini
R
R
Siani
C
C
Cataldi
A
A
Francaviglia
N
N
Silvestro
C
C
Rolandi
E
E
D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood* / Q000134:cerebrospinal fluid; D006801:Humans; D006849:Hydrocephalus / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008297:Male; D008787:Metoclopramide; D008875:Middle Aged
D001127:Arginine Vasopressin; D008787:Metoclopramide