title: Systemic absorption of oxytocin and vasopressin through eyes in rabbits.
abstract: In order to avoid injections, oxytocin and vasopressin were systemically administered through ocular route. Although oxytocin and vasopressin are small peptide drugs with only 9 amino acids, their absorptions were relatively poor. The systemic absorption of these peptides through eyes was markedly enhanced by the addition of an absorption enhancer, 0.5% Brij-78 (polyoxyethylene-20-stearyl ether), in the eyedrops of these peptides. It is concluded that it is feasible to administer oxytocin and vasopressin as eyedrops to avoid parenteral injections.
authors.affiliation: Institute of Ocular Pharmacology, Texas A&M University College of Medicine, College Station.
authors.forename: G C
authors.initials: GC
authors.lastname: Chiou
authors.forename: Z F
authors.initials: ZF
authors.lastname: Shen
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Zheng
mesh_terms: D000042:Absorption; D000287:Administration, Topical; D000818:Animals; D005123:Eye / Q000378:metabolism*; D007275:Injections, Intravenous; D010121:Oxytocin / Q000493:pharmacokinetics*; D011092:Polyethylene Glycols / Q000493:pharmacokinetics; D011817:Rabbits; D013501:Surface-Active Agents; D014667:Vasopressins / Q000493:pharmacokinetics*
chemical_list: D013501:Surface-Active Agents; D014667:Vasopressins; D011092:Polyethylene Glycols; D010121:Oxytocin; C043444:octadecyl polyoxyethylene ether