title: Riboflavin deficiency caused by treatment with adriamycin.
abstract: The present study was undertaken to determine whether administration of adriamycin causes the depletion of riboflavin content. Rats received intraperitoneal injections of adriamycin (4 mg per kg body weight) for 6 consecutive days. Urinary riboflavin excretion began to increase after 2 days of treatment with adriamycin. Erythrocyte FAD levels decreased gradually and plasma lipid peroxide contents increased markedly at the 6th day. The activity coefficient of erythrocyte glutathione reductase showed a significant increase before the decrease of flavin content and the elevation of lipid peroxide level. Therefore, the value of this coefficient obtained from erythrocyte appears to be a reliable index of riboflavin deficiency, particularly during the early stage.
authors.affiliation: Department of Medical Biochemistry, Kurume University School of Medicine, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Ogura
authors.forename: H
authors.initials: H
authors.lastname: Ueta
authors.forename: Y
authors.initials: Y
authors.lastname: Hino
authors.forename: T
authors.initials: T
authors.lastname: Hidaka
authors.forename: M
authors.initials: M
authors.lastname: Sugiyama
mesh_terms: D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005415:Flavins / Q000097:blood / Q000652:urine; D005980:Glutathione Reductase / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008929:Mitochondria, Heart / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains; D012257:Riboflavin Deficiency / Q000139:chemically induced*
chemical_list: D005415:Flavins; D008054:Lipid Peroxides; D004317:Doxorubicin; D005980:Glutathione Reductase