[Pathological changes in immune defense system of multiple-organ failure rat and their action on pathogenesis].
To explore the action of immune defense system on the mechanisms of MOF, Wistar rat MOF model was made by peritoneal injection of Zymosan. The pathological changes of MOF and the effects of neutrophils, platelets, MPS and some immune organs on MOF were studied with light and electron microscopy and image pattern analysis. At the early stage of MOF, MPS cells was in an activated status, evidenced by hyperplasia, swelling and active phagocytosis with an elevation of plasma fibronectin level, while T-lymphocyte system was damaged seriously. At the later stage, MPS declined. These results suggest that the hyperfunction of MPS be one of the initial mechanisms of rat MOF and the deficiency of cellular immunity may result in the exacerbation of the disease.
Lu
J Y
JY
304th Hospital of People's Liberation Army, Beijing.
D000818:Animals; D005353:Fibronectins / Q000097:blood; D008297:Male; D009102:Multiple Organ Failure / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D010586:Phagocytes / Q000276:immunology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D015054:Zymosan
D005353:Fibronectins; D015054:Zymosan