Radiation-protective and platelet aggregation inhibitory effects of five traditional Chinese drugs and acetylsalicylic acid following high-dose gamma-irradiation.
High doses of 60Co radiation (4.0-8.0 Gy) in mice, rats and rabbits caused increases in rate of platelet aggregation during the first 5 days after irradiation. The inhibitory effects of the extracts of five Chinese drug plants and acetylsalicylic acid on rate of platelet aggregation were observed in both in vitro and in vivo tests, averaging 23-53% in vitro and 46-69% in vivo. Antiradiation tests on mice vs. 7.5-8.0 Gy of gamma-radiation, using the plant extracts and acetylsalicylic acid as protective agents, increased survival rates by 8-50% for the plant extracts and 35% for acetylsalicylic acid.
Wang
H F
HF
Institute of Radiation Medicine, Shanghai Medical University, People's Republic of China.
Li
X D
XD
Chen
Y M
YM
Yuan
L B
LB
Foye
W O
WO
D000818:Animals; D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005720:Gamma Rays; D008297:Male; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects / Q000528:radiation effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats
D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; D011837:Radiation-Protective Agents; D001241:Aspirin