Absolute bioavailability of nicotine applied to different nasal regions.
The absolute bioavailability of nicotine administered nasally, as drops to the nasal conchae and nasal septum, and as a nasal spray, has been studied in eight healthy volunteers. Single nasal doses of 1 mg nicotine were given and plasma concentrations of nicotine were followed for 6 h. Compared to an intravenous infusion of nicotine, the bioavailability of the nasal administrations was 60 to 75%. The rate of absorption was fast, the maximum concentration being reached after about 10 min. In the present study, there was no significant difference in the rate or extent of absorption between the different nasal treatments.
Johansson
C J
CJ
Research and Development, Kabi Pharmacia AB, Helsingborg, Sweden.
Olsson
P
P
Bende
M
M
Carlsson
T
T
Gunnarsson
P O
PO
D000042:Absorption; D000280:Administration, Inhalation; D000281:Administration, Intranasal; D000328:Adult; D001682:Biological Availability; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D009300:Nasal Septum / Q000378:metabolism; D009538:Nicotine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D014420:Turbinates / Q000378:metabolism
D009538:Nicotine