[The role of the complement system in the origin of respiratory insufficiency in patients on hemodialysis].
A study was made of changes in functional status of complementary system in 42 patients with chronic renal failure on programmed hemodialysis. Early stages of hemodialysis were accompanied by short-term and reversible activation of complementary system. 100 sessions were followed by complement depression. Complement system was found to be involved in two pathogenetic mechanisms of respiratory insufficiency: block of pulmonary microcirculation by leukocytic aggregates and DIC syndrome associated with microthrombosis of the lesser circulation vessels. To manage the above complications, plasmapheresis is advocated.
Neĭmark
M I
MI
D000328:Adult; D003167:Complement Activation; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000150:complications / Q000276:immunology*; D006435:Renal Dialysis / Q000009:adverse effects*; D012131:Respiratory Insufficiency / Q000209:etiology*
Rol' sistemy komplementa v geneze dykhatel'noĭ nedostatochnosti u bol'nykh, lechennykh gemodializom.