Studies on antiatherosclerotic agents. Synthesis and inhibitory activities on platelet aggregation of 4-aryl derivatives of 7-ethoxycarbonyl-6,8-dimethyl-1 (2H)-phthalazinone.
4-Aryl derivatives of 7-ethoxycarbonyl-6,8-dimethyl-1(2H)-phthalazinone and related derivatives were newly synthesized in order to test for their inhibitory activities on platelet aggregation. 4-(2-Anisyl) compound and the corresponding 1-chloro derivative demonstrated significant activity.
Eguchi
Y
Y
Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.
Sato
Y
Y
Sekizaki
S
S
Ishikawa
M
M
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy*; D066298:In Vitro Techniques; D010793:Phthalazines / Q000138:chemical synthesis* / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*; D011817:Rabbits
D010793:Phthalazines; D010975:Platelet Aggregation Inhibitors