Circulating immune complexes in cerebrospinal fluid of patients with tuberculous meningitis.
Circulating immune complexes (ICs) were isolated from cerebrospinal fluids (CSFs) of patients with tuberculous meningitis (TBM), non-tuberculous neurological diseases by a polyethylene glycol (PEG) precipitation method. Mycobacterium tuberculosis antigen 5 was detected in CICs of 30% patients with TBM, by sandwich ELISA. CIC level decreases during antituberculosis chemotherapy and therefore its detection can provide a method to monitor the therapeutic schedule in patients with TBM.
Mathai
A
A
Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Radhakrishnan
V V
VV
Sehgal
S
S
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid; D000936:Antigen-Antibody Complex / Q000134:cerebrospinal fluid* / Q000302:isolation & purification; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D014373:Tuberculin / Q000134:cerebrospinal fluid; D014390:Tuberculosis, Meningeal / Q000188:drug therapy / Q000276:immunology*
D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; C016603:Mycobacterium tuberculosis antigen 5; D014373:Tuberculin