Toxoid preparation from venom of Bothrops colombiensis (Central and South American snake).
A new technique is described for the preparation of Bothrops venom and their different fractions toxoid. This method preserves a high degree of immunogenicity but eliminates lethal effects. All the animals vaccinated with Bothrops crude venom toxoid survived when they were injected with crude venom.
Rodriquez-Acosta
A
A
Universidad Central de Venezuela, Instituto de Medicina Tropical, Caracas.
Alonso
R
R
Castro
I
I
Aguilar
A
A
Giron
M E
ME
D000818:Animals; D003435:Crotalid Venoms / Q000276:immunology / Q000302:isolation & purification* / Q000633:toxicity; D005557:Formaldehyde; D005612:Freeze Drying; D005620:Freund's Adjuvant; D006470:Hemorrhage / Q000139:chemically induced; D007114:Immunization; D007928:Lethal Dose 50; D051379:Mice; D010447:Peptide Hydrolases; D013997:Time Factors; D014121:Toxoids / Q000276:immunology / Q000302:isolation & purification* / Q000633:toxicity
D003435:Crotalid Venoms; D014121:Toxoids; D005557:Formaldehyde; D005620:Freund's Adjuvant; D010447:Peptide Hydrolases