Targeted relaxation enhancement agents for MRI.
The design, relative merits, and initial applications of targeted relaxation enhancement agents, a new form of MRI contrast media, are briefly discussed. These agents are designed to bind reversibly to target macromolecules in a tissue of interest, thus enhancing water proton relaxation efficiency and MRI contrast. Initial applications for targeted agents include blood pool and hepatobiliary imaging.
Lauffer
R B
RB
Department of Radiology, Massachusetts General Hospital, Boston 02114.
D000818:Animals; D003287:Contrast Media; D005682:Gadolinium; D006801:Humans; D007502:Iron Chelating Agents; D008279:Magnetic Resonance Imaging; D008345:Manganese
D003287:Contrast Media; D007502:Iron Chelating Agents; D008345:Manganese; D005682:Gadolinium