Learning-related synaptic plasticity: LTP and LTD.
The past several years have seen studies of synaptic plasticity in both invertebrate and vertebrate nervous systems come of age and lead to important new findings. In particular, current evidence points to a possible presynaptic site for long-term potentiation and the involvement of a retrograde messenger from the postsynaptic neuron. Recent advances in both cerebellar and cortical forms of long-term depression are also discussed.
Siegelbaum
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Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, New York 10032.
Kandel
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D000818:Animals; D006801:Humans; D007858:Learning / Q000502:physiology*; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D013569:Synapses / Q000502:physiology*