[Double-blind study of the comparative action of indomethacin 0.1% and placebo on the breakdown of the blood-retinal barrier].
The oral fluorophotometric exploration is able to simultaneously quantify the permeability of the blood aqueous (KIN, KOUT) and blood-retinal (PVPR) barriers. It is possible to detect the breakdown of the blood aqueous barrier 3 days after cataract surgery with this fluorophotometric method. Ocular inflammation is responsible for this leakage and non steroidal anti-inflammatory drugs prevent this breakdown. In this paper, we studied the effect of 0.1% indomethacin treatment to patients before and after cataract surgery. This double-blind study was performed in 34 patients: 18 patients in the indomethacin group and 16 patients in the placebo group. We showed that the apparent transfer coefficient of fluorescein in the anterior chamber (KIN) was statistically lower in the indomethacin group (0.0220 +/- 0.0179 hr-1) than in the placebo group (0.0371 +/- 0.0187 hr-1) on the 3rd postoperative day (p = 0.027).
Coulangeon
L M
LM
Service d'ophtalmologie, C.H.R.U., Hôpital Gabriel Montpied, Clermont-Ferrand.
Allaire
C
C
al Odeh
A
A
Michel
S
S
Sole
P
P
D000328:Adult; D000368:Aged; D001813:Blood-Retinal Barrier / Q000187:drug effects*; D004311:Double-Blind Method; D015590:Fluorophotometry; D006801:Humans; D007213:Indomethacin / Q000493:pharmacokinetics* / Q000494:pharmacology; D007910:Lenses, Intraocular; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010919:Placebos; D011292:Premedication
D009883:Ophthalmic Solutions; D010919:Placebos; D007213:Indomethacin
Etude en double insu de l'action comparée de l'indométacine à 0.1% et d'un placebo sur la rupture de la barrière hémato-aqueuse.