title: Platelet surface glycoprotein changes in patients with cerebral ischemia.
abstract: In vitro abnormalities of platelet behaviour have been described in patients with ischemic cerebrovascular disease (ICD) suggesting that changes in platelet receptors and/or platelet a granules may occur in the circulation. We investigated the frequency of such alterations in 95 patients that were studied within a few days after acute stroke. Using specific antibodies to two intrinsic plasma membrane glycoproteins (GPs), the GPIIb-IIIa complex and GPIV, and to thrombospondin (TSP), a a-granular protein that becomes expressed on the platelet surface upon activation, we were able to distinguish two groups of patients: 16 patients presented an increased concentration of TSP on their platelets demonstrating in vivo platelet secretion. These patients could constitute a group with increased risk of thrombosis. In contrast, 20 patients presented a decreased concentration of GPIIb-IIIa and GPIV. This decrease in intrinsic plasma membrane GPs was associated with a decrease in mean platelet volume and may suggest the occurrence of platelet fragmentation in the circulation.
authors.affiliation: INSERM U 150, Hôpital Lariboisière, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Legrand
authors.forename: F
authors.initials: F
authors.lastname: Woimant
authors.forename: M
authors.initials: M
authors.lastname: Haguenau
authors.forename: J
authors.initials: J
authors.lastname: Caen
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D002545:Brain Ischemia / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D010980:Platelet Membrane Glycoproteins