[Studies on the chemical constituents of the root of Cocculus Trilobus DC].
Four bisbenzylisoquinoline alkaloids (I-IV) have been isolated from the roots of Cocculus trilobus DC. (Menispermaceae) growing wild in the mountainous areas of Zhejiang province. Their structures were established as isotrilobine (I), trilobine (II), isotrilobine-N-2-oxide (III) and nortrilobine (IV) on the basis of spectral analysis (UV, IR, HNMR,MS), physico-chemical constants and properties of the derivatives. III is a new alkaloid and IV was found from this plant for the first time.
Chen
H S
HS
School of Pharmacy, Second Military medical University, Shanghai.
Liang
H Q
HQ
Liao
S X
SX
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007941:Leukemia P388 / Q000473:pathology; D015394:Molecular Structure; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; C076299:isotrilobine-N-2-oxide