Nitrogranulogen-dependent inhibition of antibody synthesis. I. In vitro studies in man.
Nitrogranulogen causes a comparable suppression of immunoglobulin synthesis by human lymphocytes in vitro as a standard alkylating agent, 4-hydro-peroxycyclophosphamide. Mixed lymphocyte culture reaction-elicited T and B cell responses are especially sensitive to the agent. The immunosuppressive activity of NTG is enhanced by a thymic hormone (TFX).
Wasik
M
M
Department of Immunology, Medical School, Warsaw.
Stepień-Sopniewska
B
B
Kozakiewicz
A
A
Górski
A
A
D000917:Antibody Formation / Q000187:drug effects*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D003520:Cyclophosphamide / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D008466:Mechlorethamine / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013947:Thymosin / Q000494:pharmacology
D007166:Immunosuppressive Agents; D008466:Mechlorethamine; D013947:Thymosin; D003520:Cyclophosphamide; C011272:perfosfamide