title: Cancer treatment with interleukins 1, 4 and 6 and combinations of cytokines: a review.
abstract: During the last few years the anticancer effects of recombinant cytokines has been studied in animal experiments and in clinical trials. Significant anticancer effects of especially, interleukin-2 (IL-2) and interferon alpha (IFN alpha) have been obtained. In this paper, we shall focus on the studies and possible applications of interleukin 1 (IL-1), interleukin 4 (IL-4), interleukin 6 (IL-6) as single agents and focus on some combinations of cytokines. Finally, we shall discuss future developments that can be expected.
authors.affiliation: Instituut voor Pathologie, Academisch Ziekenhuis, Utrecht, The Netherlands.
authors.forename: H F
authors.initials: HF
authors.lastname: Dullens
authors.forename: C L
authors.initials: CL
authors.lastname: De Wit
mesh_terms: D000818:Animals; D016207:Cytokines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007375:Interleukin-1 / Q000627:therapeutic use; D015847:Interleukin-4 / Q000627:therapeutic use; D015850:Interleukin-6 / Q000627:therapeutic use; D009369:Neoplasms / Q000628:therapy*
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D015847:Interleukin-4