title: Toxoid preparation from venom of Bothrops colombiensis (Central and South American snake).
abstract: A new technique is described for the preparation of Bothrops venom and their different fractions toxoid. This method preserves a high degree of immunogenicity but eliminates lethal effects. All the animals vaccinated with Bothrops crude venom toxoid survived when they were injected with crude venom.
authors.affiliation: Universidad Central de Venezuela, Instituto de Medicina Tropical, Caracas.
authors.forename: A
authors.initials: A
authors.lastname: Rodriquez-Acosta
authors.forename: R
authors.initials: R
authors.lastname: Alonso
authors.forename: I
authors.initials: I
authors.lastname: Castro
authors.forename: A
authors.initials: A
authors.lastname: Aguilar
authors.forename: M E
authors.initials: ME
authors.lastname: Giron
mesh_terms: D000818:Animals; D003435:Crotalid Venoms / Q000276:immunology / Q000302:isolation & purification* / Q000633:toxicity; D005557:Formaldehyde; D005612:Freeze Drying; D005620:Freund's Adjuvant; D006470:Hemorrhage / Q000139:chemically induced; D007114:Immunization; D007928:Lethal Dose 50; D051379:Mice; D010447:Peptide Hydrolases; D013997:Time Factors; D014121:Toxoids / Q000276:immunology / Q000302:isolation & purification* / Q000633:toxicity
chemical_list: D003435:Crotalid Venoms; D014121:Toxoids; D005557:Formaldehyde; D005620:Freund's Adjuvant; D010447:Peptide Hydrolases