Temperature dependence of hypoxia-induced calcium accumulation in gerbil hippocampal slices.
Microfluorometry was used to investigate temperature dependence of hypoxia-induced intracellular calcium accumulation in gerbil hippocampal slice. When slices were superfused with hypoxic medium at 37 degrees C, 35 degrees C, 33 degrees C or 31 degrees C, latencies of acute increase of calcium accumulation, which was accompanied by a large negative shift of extracellular DC potentials, were delayed in a dose-dependent manner: mean latencies in field CA1 were 130 s, 182 s, 232 s and 277 s after hypoxia, respectively. This retardation in calcium accumulation may be involved in the mechanisms by which hypothermia diminishes ischemic injury.
Mitani
A
A
Department of Physiology, School of Medicine, Ehime University, Japan.
Kadoya
F
F
Kataoka
K
K
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015687:Cell Hypoxia; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D007700:Kinetics; D008564:Membrane Potentials; D011712:Pyramidal Tracts / Q000378:metabolism / Q000502:physiology; D013696:Temperature
D002118:Calcium