Further investigations into the relationship between the dopaminergic system, ascorbic acid and uric acid in the rat striatum.
Levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA), dehydroascorbic acid (DHAA), and uric acid were determined in the rat striatum following single apomorphine (1 mg/kg), scopolamine (0.6 mg/kg), pilocarpine (4 mg/kg), or pilocarpine + scopolamine (4 and 0.6 mg/kg, respectively) injections. The decrease in DOPAC levels and in the DOPAC/DA ratio, induced by the pharmacological manipulation, was linearly correlated with the increase in DHAA levels (r = -0.9060, P less than 0.05) and with the increase in the DHAA/AA ratio (r = -0.9004, P less than 0.05), respectively. It is concluded that dopaminergic activation or cholinergic inhibition both increase striatal AA oxidation, which is correlated with a decrease in DA turnover.
Desole
M S
MS
Institute of Pharmacology, University of Sassari, Italy.
Miele
M
M
Esposito
G
G
Enrico
P
P
Fresu
L
L
De Natale
G
G
Miele
E
E
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001205:Ascorbic Acid / Q000378:metabolism*; D001831:Body Temperature / Q000187:drug effects; D003342:Corpus Striatum / Q000378:metabolism*; D003683:Dehydroascorbic Acid / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010084:Oxidation-Reduction; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects; D014527:Uric Acid / Q000378:metabolism*
D010862:Pilocarpine; D015102:3,4-Dihydroxyphenylacetic Acid; D014527:Uric Acid; D012601:Scopolamine; D001058:Apomorphine; D001205:Ascorbic Acid; D004298:Dopamine; D003683:Dehydroascorbic Acid