[A high-resolution 31P-NMR study of the disorders in the energy metabolic system of Ehrlich ascites cancer cells exposed to antitumor preparations].
The disturbance in energetic metabolism of Ehrlich ascite carcinoma cells during antitumor drug treatment was examined using high-resolution 31P-NMR. The value of antitumor drug effect was shown to be characterized by the kinetics of ATP and KF level alteration in tumor cells. The results correlated with the indexes of therapeutical activity of studied drugs.
Semenova
N A
NA
Shchelok
E P
EP
Ostrovskaia
L A
LA
Sibel'dina
L A
LA
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D004734:Energy Metabolism / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D010761:Phosphorus Radioisotopes
D000970:Antineoplastic Agents; D010761:Phosphorus Radioisotopes
Issledovanie metodom 31P-IaMR vysokogo razresheniia narusheiĭ v sisteme énergeticheskogo metabolizma kletok astsitnogo raka Erlikha pri vozdeĭstvii protivoopukholevykh preparatov.