A pilot follow-up study of childhood soft signs and the development of adult psychopathology.
A subgroup of subjects (4 of 12) with childhood soft signs and adolescent anxiety-withdrawal disorders were followed up into adulthood and assessed for soft signs and psychiatric diagnoses. These subjects continued to have soft-sign abnormalities and most had adult anxiety or affective disorders, including obsessive-compulsive disorder (OCD). In contrast, control subjects with childhood soft signs but no adolescent anxiety disorders had fewer soft signs at follow-up and no discrete adult anxiety or affective disorders, but they did have obsessive-compulsive symptoms that did not meet criteria for OCD.
Hollander
E
E
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
DeCaria
C M
CM
Aronowitz
B
B
Klein
D F
DF
Liebowitz
M R
MR
Shaffer
D
D
D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000503:physiopathology; D002648:Child; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D009460:Neurologic Examination; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D010553:Personality Development; D010865:Pilot Projects