title: Studies on immunostimulating derivatives: synthesis of some pyrrolo[1,2-c]pyrimidines.
abstract: In a search for potential immunomodulating agents novel pyrrolo[1,2-c]pyrimidines were synthesized and their structures elucidated by spectroscopic means. Unfortunately, most of them were cytotoxic and devoid of effects on T lymphocyte lymphoblastic transformation. Furthermore, they were inactive in the locomotor activity test in mice.
authors.affiliation: Groupe de Recherche en Pharmacochimie, Faculté de Pharmacie, Clermont-Ferrand, France.
authors.forename: E H
authors.initials: EH
authors.lastname: Bahaji
authors.forename: P
authors.initials: P
authors.lastname: Tronche
authors.forename: J
authors.initials: J
authors.lastname: Couquelet
authors.forename: S
authors.initials: S
authors.lastname: Harraga
authors.forename: J
authors.initials: J
authors.lastname: Panouse-Perrin
authors.forename: C
authors.initials: C
authors.lastname: Rubat
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D006993:Hypnotics and Sedatives; D011743:Pyrimidines; D011744:Pyrimidinones; D011758:Pyrroles