All-trans retinoyl beta-glucose: chemical synthesis, growth-promoting activity, and metabolism in the rat.
All-trans retinoyl beta-glucose was chemically synthesized in good yield by reaction of retinoyl fluoride with glucose. Retinoyl glucose, which is soluble in water, shows growth-promoting activity similar to retinyl acetate in vitamin A-deficient rats. In metabolic studies, retinoyl glucose was found to be hydrolyzed to retinoic acid, but at a slower rate. The possible therapeutic uses of retinoyl glucose are discussed.
Barua
A B
AB
Department of Biochemistry and Biophysics, Iowa State University, Ames 50011.
Olson
J A
JA
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D005947:Glucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000627:therapeutic use; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012176:Retinoids / Q000302:isolation & purification; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000627:therapeutic use; D014802:Vitamin A Deficiency / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology
D012176:Retinoids; C073343:retinoylglucose; D014212:Tretinoin; D005947:Glucose