[Treatment of Mooren's ulcer by the combination of periectomy and corticotherapy. Apropos of 6 cases].
In this article, the authors recall the two clinical forms of Mooren ulcer (the classical and torpid one, and the inflammatory one), the autoimmune hypothesis which is unanimously accepted to explain its pathophysiology and the therapeutic problems because of the frequency of recurrences. On the basis of 6 cases (2 classical forms and 4 inflammatory) studied from 1988 to 1990 in patients with a mean age of 35 years all of them black Senegalese, they propose a new kind of treatment combining a periectomy and local and systemic corticosteroids. They stress the success of such a combination: the healing of the ulcer is rapid (35 days on average). The inflammatory form heals more rapidly (14 days, number 4) than the classical one (4 months, case number 6) without any recurrence one year later. They try to propose a pathophysiological explanation for this success: the periectomy seems to suppress the cause of the (immunate) conflict and to have an autohemotherapic action; corticosteroids seem to be both immunosuppressive and anti-inflammatory. The authors would like to extend their experiment to larger series.
Faye
M
M
Service d'Ophtalmologie, Hôpital Principal Dakar, Sénégal.
Lam
A
A
Borzeix
A
A
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000628:therapy; D003131:Combined Modality Therapy; D003320:Corneal Ulcer / Q000188:drug therapy / Q000276:immunology* / Q000601:surgery; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013256:Steroids
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D013256:Steroids
Traitement de l'ulcère de Mooren par l'association périectomie-corticothérapie. A propos de 6 cas.