Mass spectrometric investigation of 2-aminopropiophenones and some of their metabolites.
Complex metabolic mixtures of 2-aminopropiophenones, obtained both after in vitro and human in vivo metabolism of these compounds, have been investigated using both mass spectrometry and gas chromatography/mass spectrometry. The mass spectrometric fragmentation schemes of the compounds have been proposed and verified. The schemes are based on the characteristic fragments obtained by alpha-cleavage of these compounds using direct inlet mass spectrometry or gas chromatography/mass spectrometry. These findings were confirmed with chemical ionization mass spectrometry, when quasi-molecular (MH+) ions were obtained as the highest relative abundance ions for all the compounds investigated, and were used in metabolic investigations of 2-aminopropiophenones.
Pokrajac
M
M
Department of Pharmacology and Pharmacokinetics, Faculty of Pharmacy, University of Belgrade, Yugoslavia.
Miljković
B
B
Misailović
B
B
D016642:Bupropion / Q000378:metabolism / Q000652:urine; D004053:Diethylpropion / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D066298:In Vitro Techniques; D013058:Mass Spectrometry / Q000379:methods; D011427:Propiophenones / Q000378:metabolism* / Q000652:urine
D011427:Propiophenones; D016642:Bupropion; C034349:metamfepramone; D004053:Diethylpropion