Murine radiation myeloid leukaemogenesis: a possible role for radiation-sensitive sites on chromosome 2.
There is a paucity of informative data on the potentially important role of specific sites of chromosomal instability in oncogenic processes. Chromosome 2 deletions and rearrangements are known to characterise radiation-induced acute myeloid leukaemia in the mouse. Here we statistically establish a concordance between chromosome 2 breakpoint clusters in these leukaemias and chromosome 2 rearrangements carried at a high in vivo frequency by progeny of irradiated haemopoietic cells. Mechanisms of radiation myeloid leukaemogenesis are discussed with respect to multiple radiation-sensitive sites encoded on chromosome 2 and the possible influence of genomic imprinting on inductive processes.
Breckon
G
G
Medical Research Council Radiobiology Unit, Didcot, Oxon, United Kingdom.
Papworth
D
D
Cox
R
R
D000512:Alpha Particles; D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002875:Chromosomes / Q000528:radiation effects*; D005260:Female; D007621:Karyotyping; D007942:Leukemia, Experimental / Q000235:genetics*; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D014916:Whole-Body Irradiation; D014965:X-Rays