[Comparative studies of toothpastes and toothpaste ingredients in biological systems: 1. Can various toothpastes be differentiated by relative biological effectiveness in cell culture studies?].
The cytotoxicity of 15 commercial toothpastes was examined in human epithelial cell cultures. The following parameters were evaluated: protein concentration, DNA-synthesis, cell morphology and autoradiography. In comparison to the control cell culture, one toothpaste had no influence on the cell growth at all. The other pastes caused a more or less strong growth inhibition, which also depended on the concentration of the toothpaste suspension. The presented investigations showed that the cytotoxicity tests applied to toothpastes yielded a good validity.
Gerckens
B
B
Zentrum Zahn-, Mund- und Kieferheilkunde, Universität Göttingen.
Eisinger
G
G
Kaden
P
P
Krüger
W
W
D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D006801:Humans; D014100:Toothpastes / Q000633:toxicity*
D014100:Toothpastes; D004247:DNA
Vergleichende Untersuchungen von Zahnpasten und Zahnpasten-Bestandteilen in biologischen Systemen: 1. Lassen sich verschiedene Zahnpasten im Zellkulturversuch bezüglich ihrer biologischen Wirkung differenzieren?