In vitro anti-oxidant property of protein-A of Staphylococcus aureus.
Protein-A (PA) is a cell-surface glycoprotein of S. aureus Cowan I with immunomodulatory and anti-tumor activities, and ability to ameliorate cyclophosphamide and carbontetrachloride (CCl4) induced toxicity in rodents. The likely mechanism of this effect appears to be the anti-oxidant property of PA, evidenced in the present study by inhibition of CCl4 and Fe2-ascorbate induced lipid peroxidation in rat liver homogenates and inhibition of deaminative-oxidative degradation of L-glutamate into 2-thiobarbituric acid reactive products in a constituted chemical system. The anti-oxidant property of PA seem to arise from its molecular characteristics and the ability to interact with a superoxide derived free-radical species without any affinity for superoxide anion, hydroxyl radical and singlet oxygen species.
Agarwal
D K
DK
Industrial Toxicology Research Centre, Lucknow, India.
Ray
P K
PK
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors; D005609:Free Radicals; D015227:Lipid Peroxidation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013205:Staphylococcal Protein A / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000378:metabolism*
D000975:Antioxidants; D005609:Free Radicals; D013205:Staphylococcal Protein A; D003520:Cyclophosphamide; D002251:Carbon Tetrachloride