The possible mechanism of action of IgG antibodies and platelets protecting against Trypanosoma cruzi infection.
1. The role of IgG antibody and platelets in the mechanism of defense against Trypanosoma cruzi infection is reviewed. 2. Experimental data showing the participation of the different IgG subclasses in the immune lysis and immune clearance of the parasites are discussed. 3. The involvement of the platelets in the removal of the parasites from the circulation is considered. 4. It is suggested that IgG anti-T. cruzi antibodies interact with circulating parasites leading to formation of microaggregates, activation of C3 and deposition of C3b on the immune aggregates followed by adherence of platelets through C3b receptors. The immune aggregates would then be taken up by cells of the mononuclear phagocytic system.
Takehara
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Centro de Pesquisa e Formação em Imunologia, Instituto Butantan, São Paulo, Brasil.
Mota
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D000818:Animals; D000913:Antibodies, Protozoan / Q000502:physiology*; D001792:Blood Platelets / Q000502:physiology*; D014355:Chagas Disease / Q000276:immunology*; D003167:Complement Activation; D003176:Complement C3 / Q000502:physiology; D003179:Complement C3b / Q000502:physiology; D006801:Humans; D007114:Immunization; D007074:Immunoglobulin G / Q000502:physiology*; D051379:Mice
D000913:Antibodies, Protozoan; D003176:Complement C3; D007074:Immunoglobulin G; D003179:Complement C3b