GTP-binding proteins and potassium channels involved in synaptic plasticity and learning.
Inhibition of potassium channels is possibly the first step in the sequence of biochemical events leading to memory formation. These channels appear to be regulated directly or indirectly by GTP-binding proteins (G proteins), which may themselves be affected by phosphorylation and dephosphorylation in response to elevated calcium levels or other phenomena resulting from the blockage of the potassium channels. A wide variety of cellular phenomena, from transcriptional changes to axonal transport, are thus capable of being initiated by these events.
Nelson
T J
TJ
Neural Systems Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892.
Alkon
D L
DL
D000818:Animals; D002118:Calcium / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D015640:Ion Channel Gating; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D010766:Phosphorylation; D011188:Potassium / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D016283:Proto-Oncogene Proteins p21(ras) / Q000502:physiology; D011817:Rabbits; D051381:Rats; D015398:Signal Transduction
D015221:Potassium Channels; D011505:Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins; D016283:Proto-Oncogene Proteins p21(ras); D011188:Potassium; D002118:Calcium