The cell mediated and humoral immune response to vaccination with acellular and whole cell pertussis vaccine in adult humans.
The cell mediated immune response (CMI) against pertussis antigens following vaccination with the traditional Danish whole cell pertussis vaccine (WC-P) and the Japanese acellular pertussis vaccine (A-PV) JNIH-3 was studied in four adult human volunteers. Vaccination with the A-PV induced an in vitro proliferative response of peripheral blood lymphocytes to pertussis toxin (PT) subunits S2-S4, S3-S4 and S5 and the filamentous hemagglutinin (FHA), and a better serological response to native PT, detoxified PT (dPT) and FHA than the WC-PV. The induced CMI and serological response were followed over a period of 17 weeks, and were not seen to decline during this period. Further, an in vitro proliferative response to Bordetella pertussis agglutinogen 2 and 3 were demonstrated using lymphocytes from recently and not-so-recently pertussis-vaccinated adults.
Petersen
J W
JW
Bacterial Vaccine Department, Statens Seruminstitut, Copenhagen, Denmark.
Ibsen
P H
PH
Bentzon
M W
MW
Capiau
C
C
Heron
I
I
D018829:Adhesins, Bacterial; D000328:Adult; D000917:Antibody Formation; D002455:Cell Division / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D006388:Hemagglutinins / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D010567:Pertussis Vaccine / Q000276:immunology*; D014611:Vaccination; D010566:Virulence Factors, Bordetella
D018829:Adhesins, Bacterial; D006388:Hemagglutinins; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella; C065273:filamentous hemagglutinin adhesin, Bordetella pertussis