title: Antityphoid and antitetanic intradermal vaccination of chronic neuropsychic patients in a typhoid fever outbreak.
abstract: Intradermal immunization of 229 chronic neuropsychic patients in Gura Ocnitzei Sanatorium, Dîmbovitza County, where a typhoid fever outbreak burst, was performed with a freeze-dried typhoid vaccine, suspended in purified and concentrated tetanic anatoxin. Adverse reactions were minimal and immunologic response, evaluated by laboratory tests, was good, reaching the level of that obtained as a result of classic vaccination methods (subcutaneous antityphoid and intramuscular anti-tetanic). Both after vaccination and also booster O and H agglutinating titers increased 4-7 times and anti-S. typhi. seroprotecting effect reached and maintained a high level. Moreover, antityphoid vaccination permitted epidemic focus limiting and its complete extinguishing after booster. Antitetanic vaccination resulted in protecting titers settlement (greater than or equal to 0.01 IU/ml) in all previously non-protected persons (1/3 of all subjects) and in the increase of protecting titers, existing before vaccination in the other persons.
authors.affiliation: Cantacuzino Institute, Bucharest, Romania.
authors.forename: G
authors.initials: G
authors.lastname: Dimache
authors.forename: M
authors.initials: M
authors.lastname: Croitoru
authors.forename: M
authors.initials: M
authors.lastname: Ionescu
authors.forename: M
authors.initials: M
authors.lastname: Săvulescu
authors.forename: S
authors.initials: S
authors.lastname: Durbacă
authors.forename: A
authors.initials: A
authors.lastname: Dimache
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004196:Disease Outbreaks / Q000517:prevention & control* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007277:Injections, Jet; D008297:Male; D001523:Mental Disorders / Q000276:immunology*; D008875:Middle Aged; D012383:Romania / Q000453:epidemiology; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D014435:Typhoid Fever / Q000453:epidemiology / Q000517:prevention & control*; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology
chemical_list: D013745:Tetanus Toxoid; D014436:Typhoid-Paratyphoid Vaccines