[The bioequivalence of doxycycline in two preparations in capsule form].
In a randomized cross-over study the bioavailability of doxycycline (CAS 17086-28-1) in two preparations was examined by determining AUC and Cmax. The bioavailability of Doxycyclin-Kapseln (T = test preparation) relatively to a reference preparation (R) in 20 healthy subjects. Statistical analysis of plasma concentration curve and maximum concentration showed no differences between the pharmaceutical preparations tested. Both preparations proved to be bioequivalent.
Balogh
A
A
Institut für Klinische Pharmakologie, Friedrich-Schiller-Universität Jena.
Rechenbach
C
C
Brix
R
R
Mundhenke
J
J
Tjuljumbow
R
R
Hoffmann
A
A
D000328:Adult; D001682:Biological Availability; D002214:Capsules; D004318:Doxycycline / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans
D002214:Capsules; D004318:Doxycycline
Untersuchungen zur Bioäquivalenz von Doxycyclin bei zwei Präparaten in Kapselzubereitung.