Expression of the dystrophin gene in mouse and rat brain.
Duchenne muscular dystrophy is due to mutations in the dystrophin gene which is predominantly expressed in muscle and brain. Since the disease is associated with cognitive impairment, we sought to localize dystrophin mRNA in brain using in situ hybridization with oligonucleotide probes. We find the gene strongly expressed in the hippocampus and cerebral cortex, areas with an established cognitive function, and also in the Purkinje cells of the cerebellum, an area associated with motor coordination.
Gorecki
D
D
MRC Molecular Neurobiology Unit, University of Cambridge Medical School, England.
Geng
Y
Y
Thomas
K
K
Hunt
S P
SP
Barnard
E A
EA
Barnard
P J
PJ
D000818:Animals; D001921:Brain / Q000502:physiology*; D016189:Dystrophin / Q000235:genetics*; D015870:Gene Expression; D051379:Mice; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D051381:Rats
D016189:Dystrophin; D015345:Oligonucleotide Probes; D012333:RNA, Messenger