title: Renal complications of intravesical bacillus Calmette-Guérin therapy.
abstract: We report 3 patients who developed signs of systemic infection and renal insufficiency after intravesical bacillus Calmette-Guérin (BCG) instillations for a bladder cancer. Renal biopsy showed tubulo-interstitial nephritis with or without epithelioid granulomas in 2 cases, and mesangial glomerulonephritis in the last case. All patients had granulomatous hepatitis in association. It seems that hematogenous dissemination via a traumatic instillation of BCG and/or an immune-complex mechanism may have contributed to the renal damage, which was only partially reversible in 2 patients.
authors.affiliation: Department of Immunology, University of Rangueil, Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Modesto
authors.forename: L
authors.initials: L
authors.lastname: Marty
authors.forename: J M
authors.initials: JM
authors.lastname: Suc
authors.forename: D
authors.initials: D
authors.lastname: Kleinknecht
authors.forename: J F
authors.initials: JF
authors.lastname: de Frémont
authors.forename: T
authors.initials: T
authors.lastname: Marsepoil
authors.forename: P
authors.initials: P
authors.lastname: Veyssier
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine / Q000009:adverse effects* / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000628:therapy; D005921:Glomerulonephritis / Q000209:etiology; D006099:Granuloma / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*; D008107:Liver Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000209:etiology; D010212:Papilloma / Q000628:therapy; D001749:Urinary Bladder Neoplasms / Q000628:therapy
chemical_list: D001500:BCG Vaccine