[The slowing of the extinction of a conditioned reaction and the antiamnesic action of arginine vasopressin and des-glycine-(8-arginine) vasopressin].
In the experiments on mice there were analysed the effects of arginine-vasopressin (AVP) and its analogue des-glycine-arginine-vasopressin (DG-AVP) on the extinction of the conditioned reaction of passive avoidance and the reproduction of memory trace in amnesia caused by detaining the animal in the dangerous section of the unit after electrocutaneous stimulation. An increase of resistance of the conditioned reaction to a sharp extinction at systemic administration of AVP and DG-AVP was shown.
Dubrovina
N I
NI
Papsuevich
O S
OS
Chipens
G I
GI
D000647:Amnesia / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D005108:Extinction, Psychological / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C
D001127:Arginine Vasopressin; C015119:argipressin, des-GlyNH2(9)-
Zamedlenie ugasheniia uslovnoĭ reaktsii i antiamnezicheskoe deĭstvie arginin-vazopressina i dez-glitsin-(8-arginin)-vazopressina.