Change of ras-transformed NRK-cells back to normal morphology by mycalamides A and B, antitumor agents from a marine sponge.
Mycalamide A and mycalamide B, isolated as antiviral and antitumor agents from a New Zealand sponge of the genus Mycale, converted the morphology of ras-transformed NRK-cells to normal morphology at 10 and 1 ng/ml, respectively. The effect on protein synthesis suggests that these agents converted the morphology by preferentially inhibiting the biosynthesis of p21 protein.
Ogawara
H
H
Department of Biochemistry, Meiji College of Pharmacy, Tokyo, Japan.
Higashi
K
K
Uchino
K
K
Perry
N B
NB
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D011905:Genes, ras / Q000187:drug effects*; D011161:Porifera / Q000737:chemistry*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D011714:Pyrans / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D011500:Protein Synthesis Inhibitors; D011714:Pyrans; C059647:mycalamide B; C059646:mycalamide A