Action of endogenous prostaglandins on postprandial pyloric motility: a possible modulation by fats.
The involvement of endogenous prostaglandins (PGs) and the effect of exogenous PGs on the myoelectrical activity of the pylorus were examined for 6 hours after a meal in dogs chronically fitted with intraparietal electrodes on the gastroduodenal junction. The animals received either a standard meal or a fat meal which consisted of canned food added or not (standard meal) with arachis oil. The cyclooxygenase inhibitors, indomethacin (1 mg/kg) and piroxicam (0.2 mg/kg) given prior a fat meal significantly increased the frequency of pyloric spike bursts but did not modify the pyloric motility associated with a standard meal. Synthetic derivatives of PGE1 (misoprostol, 5-10 micrograms/kg) or PGE2 (enprostil 0.5-1 micrograms/kg) reduced the frequency of pyloric contractions after a fat but not a standard meal. It is suggested that both endogenous and exogenous prostaglandins may modulate postprandial pyloric motility when fats are present in sufficient amount into the meal.
Lopez
Y
Y
Department of Pharmacology, INRA, Toulouse, France.
Fioramonti
J
J
Bueno
L
L
D000284:Administration, Oral; D000818:Animals; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D004285:Dogs; D004386:Duodenum / Q000187:drug effects; D004576:Electromyography; D016620:Enprostil / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D016595:Misoprostol / Q000494:pharmacology; D010894:Piroxicam / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology*; D011706:Pyloric Antrum / Q000187:drug effects; D011708:Pylorus / Q000187:drug effects*; D013997:Time Factors
D004041:Dietary Fats; D016595:Misoprostol; D010894:Piroxicam; D011451:Prostaglandin-Endoperoxide Synthases; D016620:Enprostil; D007213:Indomethacin