[Evaluation of the effect of the detergent Rokafenol N-8 on the development and course of experimental pneumoconiosis caused by coal mine dust].
Experimental investigation was conducted in order to evaluate the impact of the Rokafenol N-8 detergent upon the development and course of experimental pneumoconiosis caused by mine dusts. albino rats were used for the experiment. Methodological assumptions were elaborated based on the analogy with the conditions observed at the workplaces, where means of dustiness control are used. Following experiments constituted the basis for the evaluation of the influence of Rokafenol N-8 detergent upon the development of pneumoconiotic and reactive changes in the lungs of experimental animals: following the introduction of the dust suspended in Rokafenol N-8 solution into the lungs, and following the intratracheal dust introduction--the animals were exposed to Rokafenol N-8 aerosol. After the close of the experimental period (3 and 6 months respectively), histopathological investigation of the lungs and mediastinal lymph nodes, and the hydroxyproline (collagen) levels in the pulmonary tissue were determined. On the basis of the investigation results obtained it has been established that Rokafenol N-8 does not eliminate coniotic changes caused by mine dusts, and additionally, it presents an impact detrimental for the organism. Rokafenol N-8 administered both intratracheally and through inhalation causes a significant increase in the hydroxyproline (collagen) level in the pulmonary tissue.
Szaflarska-Stojko
E
E
Zakładu Doświadczalnej Patologii Pracy Instytutu Medycyny Pracy w Sosnowcu.
Szymczykiewicz
K
K
Olczyk
D
D
D000280:Administration, Inhalation; D000818:Animals; D000874:Anthracosilicosis / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D003031:Coal / Q000009:adverse effects*; D003032:Coal Mining; D003902:Detergents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D004195:Disease Models, Animal; D004391:Dust / Q000009:adverse effects; D006909:Hydroxyproline / Q000378:metabolism*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical
D003031:Coal; D003902:Detergents; D004391:Dust; D006909:Hydroxyproline
Ocena wpływu detergentu rokafenol n-8 na rozwój i przebieg doświadczalnej pylicy wywołanej pyłami kopalnianymi.