Bi-phenotypic t(9;22)-positive leukemia cell lines from a patient with acute leukemia: NALM-20, established at the onset; and NALM-21, NALM-22 and NALM-23, established after relapse.
Four leukemia cell lines; NALM-20, established at the onset of leukemia and NALM-21, -22 and -23 established at the relapse of the disease were found to be t(9;22)-positive leukemia lines having the biphenotypic feature of B cell and myeloid cell characteristics. In addition, a polyclonal Epstein-Barr virus-transformed normal B cell line, B250, was established from the peripheral blood at the onset of the disease.
Matsuo
Y
Y
Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Inc.
Ariyasu
T
T
Ohmoto
E
E
Kimura
I
I
Minowada
J
J
D000954:Antigens, Surface; D015139:Blotting, Southern; D002051:Burkitt Lymphoma / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D014407:Tumor Cells, Cultured
D000954:Antigens, Surface; D004273:DNA, Neoplasm