Abnormalities in the glycosylation of IgG in spouses of patients with rheumatoid arthritis. A family study.
Forty-seven members of eight families with a rheumatoid proband were analysed for abnormal glycosylation of IgG. The results (%G(o) which is the percentage of oligosaccharide chains lacking galactose) were corrected for age and expressed as SD units about the mean for the normal population. Seven of 8 probands, 3/8 spouses, 3/5 RA relatives and 4/26 non-RA relatives had %G(o) values greater than 1SD above the age corrected mean for the normal control population (P less than 0.001, less than 0.01, less than 0.005 and greater than 0.5 respectively). A further 13 spouse pairs were studied. Ten of 13 probands and 8/13 spouses had %G(o) values greater than 1SD above the mean (P less than 0.001 and less than 0.001 respectively). Thus in total, a strikingly high number of unaffected spouses had high %G(o) values (11/21). IgM, IgA and IgG rheumatoid factors were studied. While RA patients' sera showed a correlation between IgM and IgA rheumatoid factors and %G(o), (IgM, r = 0.41 0.05 greater than P greater than 0.02, IgA, r = 0.36, P = 0.05), no correlation between IgG RF and %G(o) was noted in the RA patients. No correlation was found between any of the RF classes and %G(o) in spouses and non-RA relatives.
Sumar
N
N
Department of Immunology, University College, Middlesex Hospital School of Medicine, London, UK.
Colaço
C B
CB
Bodman
K B
KB
Parekh
R
R
Williams
P
P
Dwek
R
R
Rademacher
T
T
Isenberg
D A
DA
Soltys
A
A
Hay
F C
FC
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D005190:Family; D005260:Female; D006031:Glycosylation; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000737:chemistry / Q000378:metabolism*; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D012217:Rheumatoid Factor / Q000032:analysis
D006684:HLA-DR Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor