title: [The effect of a chemotherapeutical amine containing toothpaste on plaque formation, gingivitis and caries in clinical and animal experiment].
abstract: "C31G" means and amine mixture, which shall be, a new "sure" substance of small toxicity and is used as an effective plaque and caries reducing chemotherapeutical substance in a tooth paste. In this study we report on: the caries reducing effect in the teeth cleaning experiment in Osborn-Mendel-rats (96 animals, 6 Groups) with C-31G-containing tooth pastes in different concentrations and also in combinations with and without fluoride. the effect of an 1% C31G-containing tooth paste on plaque formation (SLI + QHI) and gingivitis (SBI) in a clinical double blind cross over-study (section % patients, 2 groups, 2 pre-experimental OH-Plases, teeth cleaning once per day). The study results don't show the expected plaque and caries reducind effect. The results of the in vivo and in vitro experiments call for a critical examination of the substances with attention of further parameters.
authors.affiliation: Fakultät Zahn-, Mund- und Kieferheilkunde der Universität Witten/Herdecke.
authors.forename: P
authors.initials: P
authors.lastname: Stickforth
authors.forename: J
authors.initials: J
authors.lastname: Rotgans
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001622:Betaine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003731:Dental Caries / Q000517:prevention & control; D003773:Dental Plaque / Q000517:prevention & control*; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D005891:Gingivitis / Q000517:prevention & control; D006801:Humans; D051381:Rats; D014100:Toothpastes / Q000627:therapeutic use*
chemical_list: D005231:Fatty Acids, Unsaturated; D014100:Toothpastes; D001622:Betaine; C038360:C 31G
vernacular_title: Die Wirkung einer chemotherapeutischen, aminehaltigen Zahnpasta auf Plaquebildung, Gingivitis und Karies im klinischen und tierexperimentellen Versuch.