title: The cryopreserved homograft valve in the pulmonary position: mid-term results and technical considerations.
abstract: Since September 1985, 60 cryopreserved homograft valves (12 aortic and 48 pulmonary) have been implanted in the pulmonary position in 56 patients. There were 34 primary operations and 26 reoperations. The ages ranged from 15 days to 22 years; the follow-up ranged from 1 month to 5 1/2 years. The operative mortality was 3.3% (2/56). There were two late deaths (not valve related). Five patients underwent replacement of the homograft; in one patient the homograft was replaced with a heterograft valve. Pathological analysis of the explanted homografts revealed calcification of the wall with satisfactory leaflet function. The leaflets were relatively acellular. No evidence of inflammation or rejection was detected. Four explants were performed for nonvalve-related indications. There are 51 long-term survivors with a homograft in place. Forty-eight are in excellent condition; three are mildly symptomatic (not valve related). Benign pulmonary insufficiency murmurs are present in 29 patients. The presence of trivial or mild insufficiency was independent of the technique of implantation. In general, cryopreserved homograft valves function well in the right ventricular outflow tract. Longer term follow-up is necessary to confirm the superiority of the cryopreserved homograft when compared to the porcine heterograft in the right ventricular outflow tract.
authors.affiliation: Division of Cardiology, Children's Hospital, San Diego, California.
authors.forename: J J
authors.initials: JJ
authors.lastname: Lamberti
authors.forename: R D
authors.initials: RD
authors.lastname: Mainwaring
authors.forename: G F
authors.initials: GF
authors.lastname: Billman
authors.forename: B A
authors.initials: BA
authors.lastname: Hopkins
authors.forename: L
authors.initials: L
authors.lastname: George
authors.forename: J W
authors.initials: JW
authors.lastname: Mathewson
authors.forename: S E
authors.initials: SE
authors.lastname: Kirkpatrick
authors.forename: R L
authors.initials: RL
authors.lastname: Spicer
mesh_terms: D000293:Adolescent; D000328:Adult; D001021:Aortic Valve / Q000637:transplantation*; D002648:Child; D002675:Child, Preschool; D015925:Cryopreservation; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000401:mortality / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011183:Postoperative Complications; D011664:Pulmonary Valve / Q000601:surgery / Q000637:transplantation*; D015996:Survival Rate; D013997:Time Factors