[Basal studies on the model of circular excisional wounds made on the dorsal skin of rats treated with hydrocortisone].
This study was performed to establish a circular excisional wound model treated with hydrocortisone (HC-P) and to estimate the following parameters in this model: wound area, hydroxyproline (Hyp) content, histological characteristics and microscopical measurements of histological sections. HC-P inhibited the reduction of wound area, the increase in Hyp content and proliferation of granulation tissue in a dose-dependent manner. The application of ZnO ointment significantly accelerated the reduction of wound area and the increased Hyp content in rats treated with HC-P. From these results, we concluded that this experimental model is useful for the objective evaluation of the efficacy of drugs that promote wound healing.
Yoshida
A
A
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan.
Araki
T
T
Omata
T
T
Yamaguchi
I
I
Matsuda
K
K
Kurimoto
T
T
Tagashira
E
E
D000818:Animals; D003864:Depression, Chemical; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000494:pharmacology*; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D015034:Zinc Oxide / Q000494:pharmacology
D006909:Hydroxyproline; D015034:Zinc Oxide; D006854:Hydrocortisone