New antimicrobial filicinic acid derivatives from Hypericum drummondii.
Bioactivity-guided fractionation of the hexane extract of the stems and leaves of Hypericum drummondii has afforded four new filicinic acid derivatives: drummondin D, isodrummondin D, drummondin E, and drummondin F. The structures of these compounds were established by spectroscopic methods. All compounds possessed strong antibiotic activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and the acid fast bacterium Mycobacterium smegmatis.
Jayasuriya
H
H
Department of Pharmacognosy, University of Mississippi, University 38677.
Clark
A M
AM
McChesney
J D
JD
D000098:Acetophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003510:Cyclohexanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*
D000098:Acetophenones; D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D003510:Cyclohexanes; C073629:drummondin F; C073646:drummondin D; C073626:isodrummondin D; C073628:drummondin E