title: [MRT and 99mTc-HM-PAO SPECT of the brain in myasthenia gravis].
abstract: Fourteen patients suffering from myasthenia gravis underwent cranial MRI and 99mTc-HM-PAO SPECT examinations. T2-WI revealed solitary white matter and/or basal ganglia lesions in four, multiple lesions in eight patients. The evaluation of the rCBF demonstrated a circumscript decrease of cortical perfusion in one patient whereas eight patients showed multiple cortical areas of hypoperfusion. In the context of an increased incidence of intrathecal immune reaction as well as of a constantly impaired cognitive performance of these patients, imaging findings might be a correlate of a primary cerebral manifestation of myasthenia.
authors.affiliation: Institut für Neuroradiologie, Arbeitsgemeinschaft Kernspintomographie Universitätskliniken, Homburg/Saar.
authors.forename: H
authors.initials: H
authors.lastname: Henkes
authors.forename: H
authors.initials: H
authors.lastname: Jäger
authors.forename: W
authors.initials: W
authors.lastname: Dewes
authors.forename: J
authors.initials: J
authors.lastname: Hierholzer
authors.forename: U
authors.initials: U
authors.lastname: Piepgras
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D001921:Brain / Q000098:blood supply*; D004576:Electromyography; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000503:physiopathology; D009483:Neuropsychological Tests; D043025:Oligoclonal Bands; D015609:Organotechnetium Compounds; D010091:Oximes; D011950:Receptors, Cholinergic / Q000276:immunology; D012039:Regional Blood Flow / Q000502:physiology; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D001323:Autoantibodies; D007136:Immunoglobulins; D043025:Oligoclonal Bands; D015609:Organotechnetium Compounds; D010091:Oximes; D011950:Receptors, Cholinergic; D019690:Technetium Tc 99m Exametazime
vernacular_title: MRT und 99mTc-HM-PAO SPECT des Ghirns bei Myastenia gravis.