[The use of prostaglandin E2 (prostenon) in broncho-obstructive syndrome of patients with pulmonary tuberculosis].
PGE and PGF2 alpha were measured by radioimmunoassay in bronchoalveolar lavage fluid obtained from the affected and contralateral lung of 86 patients with different forms of pulmonary tuberculosis. The findings were correlated with parameters of external respiration. Bronchial obstruction (BO) was found to entail lower values of PGE in the intact lung though higher PGE2 alpha levels near the focus. To normalize the proportion PGE/PGF2 alpha in the respiratory tracts, 24 tuberculous patients with BO received adjuvant ultrasound inhalations of PGE2 (prostenon). The course of 10 daily procedures produced positive shifts in bronchial patency in 3/4 of the patients. This positive trend was still demonstrable two months later. Prostenon anti-BO effect proved the highest in new-onset tuberculosis, in tuberculosis-induced intoxication and in moderate BO.
Khomenko
A G
AG
Omarov
T O
TO
Kaminskaia
G O
GO
Blonskaia
G Iu
GIu
Lovacheva
O V
OV
D000328:Adult; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000209:etiology; D003251:Constriction, Pathologic / Q000188:drug therapy / Q000209:etiology; D015232:Dinoprostone / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000150:complications*
D015232:Dinoprostone
Primenenie prostaglandina E2 (prostanona) pri bronkhoobstruktivnom sindrome u bol'nykh tuberkulezom lëgkikh.