[Relation of HLA-I and HLA-DR to HBV-infected liver].
HLA-I and HLA-DR antigenic profiles of 34 livers with HBV infection and 15 non-HBV infected livers were analyzed. HLA-I antigen was detected on the membrane of the hepatocytes in 19 infected livers, but not in the non-HBV infected livers except in one congenital polycystic liver. The number of HLA-I Ag positive hepatocytes were correlated with the extent of the liver damage, and the positive rate of HLA-I was lower in the livers of the high HBV reduplication group (HBeAg+, HBeAb-) in comparing with the group with low HBV duplication (HBeAg-, HBeAb+). Only in two cases of chronic active hepatitis, HLA-DR Ag was detected to be expressed on the membrane of hepatocytes. The expression of HLA-I Ag on the membrane of liver cells may play a role in the recognition of hepatocytes as targets for cytotoxic T-lymphocytes which may represent an important event in the pathogenesis of hepatocellular necrosis.
Na
J
J
Department of Pathology, First Teaching Hospital of Beijing Medical University.
D002462:Cell Membrane / Q000276:immunology; D006684:HLA-DR Antigens / Q000032:analysis*; D006509:Hepatitis B / Q000276:immunology*; D006513:Hepatitis B e Antigens / Q000276:immunology; D006521:Hepatitis, Chronic / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D007124:Immunoenzyme Techniques; D008099:Liver / Q000276:immunology / Q000473:pathology
D006684:HLA-DR Antigens; D006513:Hepatitis B e Antigens; D015395:Histocompatibility Antigens Class I