title: Cutaneous granulomas in children with combined immunodeficiency.
abstract: Noninfectious cutaneous granulomas, particularly in an acral distribution, may be an early sign of mixed cellular and humoral immunodeficiency. Special stains of skin biopsy sections and cultures for bacteria, acid-fast bacilli, and fungi are important in eliminating the possibility of underlying pathogens. In three children with combined immunodeficiency and cutaneous granulomas, the administration of moderate- to high-dose systemic corticosteroids was the most effective therapy. However, careful consideration should be given before administering systemic corticosteroids to an immunocompromised patient.
authors.affiliation: Department of Dermatology, University of Iowa School of Medicine, Iowa City.
authors.forename: E C
authors.initials: EC
authors.lastname: Siegfried
authors.forename: N S
authors.initials: NS
authors.lastname: Prose
authors.forename: N J
authors.initials: NJ
authors.lastname: Friedman
authors.forename: A S
authors.initials: AS
authors.lastname: Paller
mesh_terms: D000293:Adolescent; D000361:Agammaglobulinemia / Q000150:complications; D000740:Anemia / Q000209:etiology; D002675:Child, Preschool; D005260:Female; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications; D016393:Lymphoma, B-Cell / Q000150:complications; D008297:Male; D012871:Skin Diseases / Q000209:etiology*