[The effect of GABA-ergic agents on oxidative phosphorylation in the brain mitochondria in traumatic edema].
The condition of oxidative phosphorylation in the rat brain mitochondria was studied polarographically in dynamics of the brain traumatic edema. It was found that 24 hours after the trauma the rate of oxidation in mitochondria decreased and the degree of conjugation in the respiratory chain compensatorily increased. Piracetam (1 g/kg), phenibut (50 mg/kg) and to a lesser degree sodium oxybutyrate (0.2 g/kg) prevented the 'changes and enhanced the compensatory capacities of mitochondria during the development of traumatic edema of the brain.
Novikov
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Sharov
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D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D001930:Brain Injuries / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010889:Piracetam / Q000627:therapeutic use*; D051381:Rats; D012978:Sodium Oxybate / Q000627:therapeutic use*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate; C008842:4-amino-3-phenylbutyric acid; D010889:Piracetam
Vliianie GAMK-ergicheskikh sredstv na okislitel'noe fosforilirovanie v mitokhondriiakh mozga pri ego travmaticheskom oteke.