title: Urinary levels of interleukin-6 and disease activity in patients with IgA nephropathy.
abstract: We studied, using ELISA, 27 patients with IgA nephropathy to determine if levels of urinary interleukin-6 (IL-6) might reflect the disease activity. The levels of urinary IL-6 in patients with the advanced stage were significantly higher than those in patients with the mild stage of the disease or in healthy adults. The results showed a significant correlation between the levels of urinary IL-6 and the disease activity, i.e., levels of urinary cast and urinary protein. It was thus suggested that the measurement of urinary IL-6 is useful in evaluating the degree of glomerular injuries and/or prognosis in patients with IgA nephropathy.
authors.affiliation: Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tomino
authors.forename: K
authors.initials: K
authors.lastname: Funabiki
authors.forename: H
authors.initials: H
authors.lastname: Ohmuro
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: I
authors.initials: I
authors.lastname: Shirato
authors.forename: T
authors.initials: T
authors.lastname: Shirai
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Koide
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000652:urine*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000652:urine*; D007678:Kidney Glomerulus / Q000737:chemistry; D008297:Male
chemical_list: D015850:Interleukin-6