Compatibility of bupivacaine and iohexol in two mixtures for paediatric regional anaesthesia.
The compatibility of bupivacaine (0.25% and 0.125% wt/vol) with iohexol 300 mg I/ml was investigated. At room temperature bupivacaine does not decompose in these mixtures over a period of 24 h. pH Values (7.10 and 7.33), clarity, osmolality (370 and 379 mOsm/kg) and buffer capacity (0.035 ml and 0.010 ml 0.1000 mol/l NaOH per 10 ml) meet requirements for epidural injection. Both mixtures are suitable for epidurography.
Van Asten
P
P
Department of Hospital Pharmacy, University Hospital Utrecht, The Netherlands.
Glerum
J H
JH
Spaanderman
E R
ER
Van Niekerk
J
J
Van Dijk
A
A
D000765:Anesthesia, Conduction; D002045:Bupivacaine / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D002648:Child; D003116:Color; D004344:Drug Incompatibility; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D007472:Iohexol / Q000737:chemistry; D009994:Osmolar Concentration; D012996:Solutions
D007202:Indicators and Reagents; D012996:Solutions; D007472:Iohexol; D002045:Bupivacaine