[The effect of acetylcysteine on the antioxidant system in an experimental toxic lesion of the liver].
The liver damage by CCl4 in albino rats was followed by a drastic activation of lipid peroxidation processes and suppression of most components of the antioxidant system. The administration of acetylcysteine to the affected animals exerted the positive effect which manifested itself in a decrease of lipid peroxidation products content in the blood plasma and liver and in the partial normalization of the antioxidant protection system.
Gonskiĭ
Ia I
IaI
Korda
M M
MM
Klishch
I N
IN
D000111:Acetylcysteine / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D000111:Acetylcysteine
Vliianie atsetiltsisteina na antioksidantnuiu sistemu pri éksperimental'nom toksicheskom porazhenii pecheni.