[The importance of determining trophoblastic beta 1-glycoprotein (TBG) for the early diagnosis and prognosis of placental insufficiency in pregnant women with habitual abortion].
Blood serum TBH levels were measured by enzyme immunoassay over the course of pregnancy in 40 women with normal pregnancy (controls) and 80 with a history of habitual abortions. Weekly measurements of TBH concentrations have revealed a significant reduction of its secretion over the entire pregnancy course in women with a history of habitual abortions vs. the controls (p less than 0.05; 0.01). A reduced TBH level starting from the first pregnancy trimester (4-7-fold reduction) and no manifest elevation of its concentration were the signs predicting the formation of primary placental insufficiency; the risk of its development was particularly high if these signs were associated with low placentation, detachment of the chorion, and recurring threatened abortions. A 10-fold and lower decrease of TBH level, its gradual or drastic reduction are the unfavorable signs preceding a spontaneous abortion. Therefore TBH measurements may be regarded as a screening test for the prediction and early diagnosis of developing placental insufficiency in pregnant women with a history of habitual abortions.
Mamedalieva
N M
NM
Kalafati
T I
TI
Sidel'nikova
V M
VM
Sukhikh
G T
GT
D000026:Abortion, Habitual / Q000097:blood / Q000175:diagnosis*; D000328:Adult; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D010927:Placental Insufficiency / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*; D011379:Prognosis; D013997:Time Factors
D011268:Pregnancy-Specific beta 1-Glycoproteins
Znachenie opredeleniia TBG dlia ranneĭ diagnostiki i prognozirovaniia platsentarnoĭ nedostatochnosti u beremennykh s privychnym nevynashivaniem.