Effect of clonidine on catechol metabolism in the rostral ventrolateral medulla: an in vivo electrochemical study.
The dose-dependent reduction in catechol metabolism induced by an imidazoline with alpha 2-adrenoceptor agonist specificity, clonidine, was assessed (ED50 = 7 micrograms.kg-1 i.v.) with in vivo voltammetry in the rostral ventrolateral medulla of rats kept under halothane anesthesia and strictly controlled circulatory and ventilatory conditions. This reduction in catechol metabolism was observed in intact as well as in barodeafferented rats.
Mermet
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Laboratoire de Physiologie de L'Environnement (CNRS SDI 6100), Faculté de Médecine Grange-Blanche, Lyon, France.
Quintin
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D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000294:innervation; D002396:Catechols / Q000378:metabolism*; D003000:Clonidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004563:Electrochemistry; D004837:Epinephrine / Q000502:physiology; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D002396:Catechols; C034221:catechol; D003000:Clonidine; D004837:Epinephrine