[Lipid peroxidation and myocardial contractile function in the post-ischemic period depending on the level of hypothermic protection of the heart].
The experiments on rats isolated hearts showed lipid peroxidation state to depend on myocardial cooling level in ischemic period. Cooling to 8-12 degrees C does not induce significant impairment in the system of lipid peroxidation/antioxidant activity, thus preventing the development of reperfusion impairment in cardiac activity restoration. Temperature decrease to 4-6 degrees C during the ischemic period results in lipid peroxidation, antioxidant cell system exhaustion and impairment of contractive myocardial function in reperfusion.
Boiarinov
G A
GA
Kontorshchikova
K N
KN
Mukhina
I V
IV
D000818:Animals; D000975:Antioxidants; D007036:Hypothermia, Induced; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D009200:Myocardial Contraction; D051381:Rats; D015427:Reperfusion Injury / Q000517:prevention & control*
D000975:Antioxidants
Perekisnoe okislenie lipidov i sokratitel'naia funktsiia miokarda v postishemicheskom periode v zavisimosti ot urovnia gipotermicheskoĭ zashchity serdtsa.