title: Amygdaloid kindling during wakefulness and paradoxical sleep in the cat. 1. Inhibitory influence of paradoxical sleep on kindling development.
abstract: The development of amygdaloid kindling during wakefulness (W) and paradoxical sleep (PS) was compared in chronically implanted adult male cats. The animals were divided into 2 groups. One group was kindled during W (W-K) and the second during a burst of pontogeniculo-occipital (PGO) potentials during PS (PS-K). The threshold of amygdaloid afterdischarge (AD) was determined during W in the W-K group and during PS in the PS-K group. For the development of kindling, amygdala stimulation was applied daily. Results demonstrate that kindling development was markedly retarded in the PS-K group. From the first kindling trials, mean AD duration in the PS-K group was significantly shorter than in the W-K group and this difference was sustained until generalized convulsive seizures (GCSs) were reached by the W-K animals. Also, mean AD frequency in the PS-K group was significantly lower than in the W-K group. AD propagation to the contralateral amygdala and sensorimotor cortex was significantly retarded in the PS-K animals. Time spent in behavioral stages I and II of kindling was significantly longer in the PS-K animals than in W-K animals and the number of daily electrical stimuli required to reach the first GCS was significantly higher in group PS-K than in group W-K. It is concluded that PS exhibits an inhibitory influence over amygdaloid kindling development and this influence is mainly exerted during the early stages of epileptogenesis.
authors.affiliation: Departamento de Cronobiología, Instituto Mexicano de Psiquiatría, Mexico City.
authors.forename: J M
authors.initials: JM
authors.lastname: Calvo
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D002415:Cats; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D012895:Sleep, REM / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*