title: Enhanced clearing of Helicobacter pylori after omeprazole plus roxithromycin treatment.
abstract: The in vitro antibacterial activity of omeprazole against eight strains of Helicobacter pylori was evaluated. Minimum inhibitory concentration (MIC) values were 32 micrograms/ml and 64 micrograms/ml (MIC50 and MIC90 respectively). We performed a randomized single blind study comparing the efficacy of omeprazole alone (for 4 weeks) or combined with roxithromycin (for 2 weeks) in the treatment of duodenal ulcer and chronic active gastritis associated with H. pylori infection, H. pylori was eradicated in 75% of patients treated with omeprazole alone whereas the patients treated with the combination of these drugs were completely free from H. pylori at the end of the therapy.
authors.affiliation: Istituto di Medicina Sperimentale, Università G.D'Annunzio, Chieti, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Cellini
authors.forename: L
authors.initials: L
authors.lastname: Marzio
authors.forename: A
authors.initials: A
authors.lastname: Di Girolamo
authors.forename: N
authors.initials: N
authors.lastname: Allocati
authors.forename: L
authors.initials: L
authors.lastname: Grossi
authors.forename: B
authors.initials: B
authors.lastname: Dainelli
mesh_terms: D004338:Drug Combinations; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005756:Gastritis / Q000188:drug therapy*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D009853:Omeprazole / Q000494:pharmacology*; D015575:Roxithromycin / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D015575:Roxithromycin; D009853:Omeprazole