[Pharmacokinetics of colistin sulfate administered by intravenous and intramuscular routes in the calf].
Pharmacokinetic characteristics of an extemporaneous form of colistin sulfate in young calves were studied for a dosage of 25,000 IU.kg-1. The intravenous route (IV) is characterized by a 3-compartment model whose main parameters are: volume of distribution (1.02 l.kg), body clearance (0.15 l.h-1 kg-1) and mean residence time (3.87 h). By intramuscular route (IM), a mean serum peak of 37 IU.ml-1 was reached at a mean time of 0.5 h. The mean half-time of terminal phase (6.47 h) does not differ significantly from that of the intramuscular route (4.52 h). Absolute bioavailability calculated based on 4 calves was 109 +/- 28%. Repeated IM administrations seem to be adapted to maintain a bactericidal activity and to reduce risks of toxicity and neurological disorders (25,000 IU.kg-1) every 12 h over 3d.
Renard
L
L
Centre national d'études vétérinaires et alimentaires, laboratoire des médicaments vétérinaires, Fougères, France.
Sanders
P
P
Laurentie
M
M
D000818:Animals; D001682:Biological Availability; D002417:Cattle / Q000378:metabolism*; D003091:Colistin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D014018:Tissue Distribution
D003091:Colistin
Pharmacocinétique de la colistine sulfate administrée par voies intraveineuse et intramusculaire chez le veau.