title: [Pathogenesis and therapy of ascites in liver cirrhosis].
abstract: This paper reviews pathogenetic factors which contribute to the development of therapy-resistant ascites in liver cirrhosis. Main principles are known as "Overfilling"--and "Underfilling"-hypotheses followed by disturbances of different kinds of mediators influencing renal blood flow and natriuresis. The endpoint of a cascade is the development of a hepatorenal syndrome which is connected with therapeutic resistance against diuretics. Therefore, other therapeutic methods (paracentesis, reinfusion) must be taken in to account in order to improve prognosis of such cases.
authors.affiliation: Klinik und Poliklinik für Innere Medizin Martin-Luther-Universität Halle-Wittenberg.
authors.forename: R
authors.initials: R
authors.lastname: Nilius
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology; D001201:Ascites / Q000209:etiology* / Q000628:therapy*; D003937:Diagnosis, Differential; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use; D006530:Hepatorenal Syndrome / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000401:mortality; D009318:Natriuresis; D011379:Prognosis; D011677:Punctures; D012079:Renal Circulation
chemical_list: D004232:Diuretics
vernacular_title: Pathogenese und Therapie des Ascites bei Leberzirrhose.