[Effect of activated leukocytes on pulmonary arterial pressure].
Shock model was established by intravenous injection of E Coli endotoxin with a dosage of 5 mg/kg wt in dog. An immediate fall in systemic arterial pressure (SAP) was found after injection, while an increase in pulmonary arterial pressure (PAP) and a markedly leukopenia in circulatory blood were also found. Rats lung was perfused with warm (37 degrees C) krebs solution in constant flow rate. There was an obviously increase in PAP when activated leukocytes had been added to the perfusion solution. The results suggested that activated leukocytes in the lung blood vessels may play an important role in the pathogenesis of pulmonary hypertension.
Sun
R Y
RY
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing.
D000818:Animals; D004285:Dogs; D004731:Endotoxins; D004926:Escherichia coli; D006976:Hypertension, Pulmonary / Q000209:etiology*; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000209:etiology / Q000503:physiopathology*
D004731:Endotoxins