Mutans streptococci in saliva and interdental spaces after topical applications of an antibacterial varnish in schoolchildren.
The effect of a chlorhexidine-containing varnish on the levels of mutans streptococci in saliva and in interdental spaces was investigated in 33 15-year-old schoolchildren. Each child was treated with an active (1% chlorhexidine; 1% thymol) and a placebo varnish preparation following the split-mouth technique. The varnishes were applied twice in small amounts into upper interdental areas with a 2-d interval. Mutans streptococci in saliva and interdental plaque was sampled and enumerated during 3 months. The results showed an immediate reduction of the number of interdental mutans streptococci on both test and placebo side after the varnish applications. The levels, however, were significantly lower in the test quadrants compared with the placebo-treated sides after 8, 30 and 90 d. Thus, the findings indicate a slower recolonization in interdental spaces treated with the active preparation. The levels of mutans streptococci in saliva were significantly reduced 1 and 3 months after varnish treatment, suggesting a long-term effect of the antibacterial varnish.
Petersson
L G
LG
Medical and Dental Health Center, Lanssjukhuset, Halmstad, Sweden.
Maki
Y
Y
Twetman
S
S
Edwardsson
S
S
D000293:Adolescent; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D002710:Chlorhexidine / Q000008:administration & dosage / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003692:Delayed-Action Preparations / Q000494:pharmacology; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D012463:Saliva / Q000382:microbiology*; D013295:Streptococcus mutans / Q000187:drug effects*; D013943:Thymol
D000891:Anti-Infective Agents, Local; D003692:Delayed-Action Preparations; D013943:Thymol; D002710:Chlorhexidine