Elevation of serum group II phospholipase A2 in patients with cancers of digestive organs.
We demonstrated the elevation of serum Group II phospholipase A2 (PLA2) in 56.5% of patients with cancers of digestive organs. The elevation of serum Group II PLA2 was more frequently seen in patients with advanced or metastasized cancer than in those with early cancer (66.7 vs. 35.0%). There was no correlation between serum Group II PLA2 and carcinoembryonic antigen (CEA) in these patients. A combined assay of Group II PLA2 and CEA increased the sensitivity of detection of all, early and advanced cancers from 37.1, 15.0 and 47.6% with CEA alone to 71.0, 45.0 and 83.3%, respectively.
Ogawa
M
M
Department of Surgery II, Kumamoto University Medical School, Japan.
Yamashita
S
S
Sakamoto
K
K
Ikei
S
S
D002272:Carcinoembryonic Antigen / Q000097:blood; D004067:Digestive System Neoplasms / Q000201:enzymology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2
D002272:Carcinoembryonic Antigen; D010741:Phospholipases A; D054467:Phospholipases A2