[Comparative study of hemostasis in the aorta and peripheral veins of patients with atherosclerosis of lower limb arteries].
A total of 127 male patients with obliterating atherosclerosis of lower limb arteries, stages I-IV, aged 43-76 years, were investigated. Thrombogenic potential in the blood from the upper, and lower limbs of patients was higher than in normal subjects, that was evidenced by elevation of blood platelet aggregation capacity, increased content of thrombocytic factor 4, fibrinogen concentration, and a rise in the level of soluble complexes of fibrin monomers. These changes were attended by the lowering of anticoagulant activity (a decrease in antithrombin III level) and fibrinolysis. The thrombogenic potential in the blood from the aorta was significantly higher than in the venous blood: increased intravascular spontaneous platelet aggregation, fibrinogen concentration, and significant rise in antithrombin III activity). Antithrombogenic potential of the vascular wall in patients is substantially lower as compared to that in normal subjects.
Adamchik
A S
AS
Sushkevich
G N
GN
Grishin
G P
GP
Krashutskiĭ
V V
VV
D000328:Adult; D000368:Aged; D001011:Aorta / Q000502:physiology*; D001158:Arteries; D001161:Arteriosclerosis / Q000097:blood*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D014680:Veins
Sravnitel'noe izuchenie gemostaza v aorte i perifericheskikh venakh u bol'nykh aterosklerozom arteriĭ nizhnikh konechnosteĭ.