Nitrogranulogen-dependent inhibition of antibody synthesis. II. In vivo studies in mice.
NTG in higher doses inhibits specific antibody responses in mice when given after but not prior to antigen. The drug also causes suppression of polyclonal humoral responses but to a lesser extent than other alkylating agents.
Lagodziński
Z
Z
Department of Immunology, Medical School, Warszawa.
Górski
A
A
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000941:Antigens / Q000008:administration & dosage; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008466:Mechlorethamine / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology
D000941:Antigens; D007166:Immunosuppressive Agents; D008466:Mechlorethamine