[The effects of sodium butyrate (NABT) on fibrillar centres and Ag-staining protein of nucleolus of human stomach glandular carcinoma (MGC-803) cells].
The changes in the ultrastructure of fibrillar centres, morphological type of nucleolus, and the content of Ag-nucleolus protein of Sodium Butyrate treated MGC-803 cells have been studied. It was found that the number of fibrillar centres and Ag-staining granules, content of Ag-staining protein of nucleolus were decreased, and nucleolar morphological type was changed from reticulated to ring-shaped in NaBT treated MGC-803 cells. These results indicate that NaBT regulate the proliferation and differentiation of cells by inhibiting rRNA synthesis and rDNA transcriptional activity.
Lü
G Z
GZ
Department of Cell Biology, Beijing Institute for Cancer Research.
Gao
Y
Y
Zhou
L X
LX
Lin
Z X
ZX
Zheng
Y
Y
D000230:Adenocarcinoma / Q000473:pathology*; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002466:Cell Nucleolus / Q000187:drug effects / Q000648:ultrastructure*; D006801:Humans; D016622:Silver Staining; D013274:Stomach Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured
D002087:Butyrates; D020148:Butyric Acid