Management of chronic active B hepatitis with alpha interferon.
Patients with chronic active B hepatitis entered into an open study of IFN maintenance therapy. They received 3 x 10(6) I.U. INTRON-A by subcutaneous injection three times a week for a 4-month period. Four patients out of ten became HBeAg negative and anti-HBe, which was accompanied by the return of serum liver function tests to normal. In a control group with eleven patients, given only vitamins, no changes were registered in serological and biochemical data. Fever, "flu-like illness", fatigue were the main side-effects observed during the course of IFN therapy, which had not to be discontinued.
Gróza
S
S
Institute for Infectious and Tropical Diseases, Medical Faculty University, Beograd.
Vukotić
L
L
Jemuovoć
L
L
Delić
D
D
Nikolić
P
P
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007279:Injections, Subcutaneous; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D016898:Interferon-alpha