Cloacin tolerance and aspecific colicin insensitivity of human Escherichia coli strains.
Of 182 wild-type human, aerobactin producer Escherichia coli strains 86.3% were insensitive to cloacin. All randomly chosen 51 strains were relatively cloacin tolerant. Cloacin tolerant strains were not considerably more sensitive to hydrophobic drugs than the cloacin sensitive descendant strains. Pathogenicity of the cloacin sensitive strains was significantly lower (p less than 0.05) in intraperitoneal mice infection than that of the cloacin tolerant ones. Suggesting a new aspect of the uptake mechanism of colicins, cloacin tolerance was very frequently associated with an aspecific insensitivity to a broad spectrum of colicins.
Gadó
I
I
Béla Johan National Institute of Hygiene, Budapest, Hungary.
Tóth
I
I
Milch
H
H
Czirók
E
E
Herpay
M
M
D002989:Cloacin / Q000494:pharmacology*; D003087:Colicins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006877:Hydroxamic Acids / Q000378:metabolism; D008826:Microbial Sensitivity Tests
D003087:Colicins; D006877:Hydroxamic Acids; C031819:aerobactin; D002989:Cloacin