A new prognostic index--leucocyte infiltration--in human cerebral infarcts by 99Tcm-HMPAO-labelled white blood cell brain SPECT.
Twenty-six patients with acute cerebral infarction were imaged by 99Tcm-hexamethylpropyleneamine oxime (HMPAO)-labelled white blood cell brain (Tc-WBC) single photon emission computed tomography (SPECT). The regions of interest were equally placed in the whole hemispheres of both sides with summation of all transaxial slices in the Tc-WBC SPECT. The asymmetric indices (AI) were calculated as 200[[(right - left)]/(right + left)]. Grouping of patients with cerebral infarction was based on activities of daily living (ADL) at outcome. The results showed that the poor outcome patient group had a higher AI of Tc-WBC than that of the other patients (13.0 +/- 3.0 S.E.M. versus 5.4 +/- 1.0 S.E.M., and P less than 0.05 by Wilcoxon rank sum test). In conclusion, the Tc-WBC SPECT may be considered as a new prognostic index to predict patient outcome in human cerebral ischaemic infarctions consistent with newly established ischaemic injury theories.
Kao
C H
CH
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
Wang
P Y
PY
Wang
Y L
YL
Chang
L
L
Wang
S J
SJ
Yeh
S H
SH
D000208:Acute Disease; D000368:Aged; D002544:Cerebral Infarction / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D011379:Prognosis; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime