Nitroxyl radicals decrease toxicity of cytostatic agents.
Nitroxyl radicals of a series of piperidineoxyles and pirrolinoxyles increase the tolerance of experimental animals to the injection of otherwise lethal doses of anti-tumor cytostatic agents. Simultaneous injection of nitroxyl radicals in different doses with 6-mercaptopurine, thiophosphamide, cyclophosphamide and the other cytostatic agents results in decreased toxicity and survival of animals. Nitroxyl radicals normalize the level of the oxidized form of P450 cytochrome that is decreased by the injection of lethal doses of cytostatic agents.
Konovalova
N P
NP
Institute of Chemical Physics, USSR Academy of Sciences, Chernogolovka, Moscow Region.
Diatchkovskaya
R F
RF
Volkova
L M
LM
Varfolomeev
V N
VN
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D003520:Cyclophosphamide / Q000494:pharmacology / Q000633:toxicity; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005609:Free Radicals / Q000494:pharmacology; D015122:Mercaptopurine / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D009589:Nitrogen Oxides / Q000494:pharmacology*; D013852:Thiotepa / Q000494:pharmacology / Q000633:toxicity
D000970:Antineoplastic Agents; D005609:Free Radicals; D009589:Nitrogen Oxides; D003520:Cyclophosphamide; D003577:Cytochrome P-450 Enzyme System; D013852:Thiotepa; D015122:Mercaptopurine; C039900:nitroxyl