Energy requirements for the basal efflux of noradrenaline and its metabolites from adrenergic varicosities.
The combination of hypoxia plus glucose deprivation or of hypoxia plus lactate induces carrier-mediated outward transport of 3H-noradrenaline in the rat vas deferens. Lactate efflux is higher from atria than from vas deferens. Hence, the much lower contribution by outward transport to the spontaneous efflux of 3H-noradrenaline in vas deferens than atria is likely to be due to a better supply of oxygen (and perhaps also glucose) to the 3H-noradrenaline-storing varicosities in vas deferens than in atria.
Trendelenburg
U
U
Department of Pharmacology and Toxicology, University of Würzburg, Federal Republic of Germany.
Russ
H
H
Schömig
E
E
D000818:Animals; D004734:Energy Metabolism; D006019:Glycolysis; D006325:Heart Atria; D007773:Lactates / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D051381:Rats; D014316:Tritium; D014649:Vas Deferens / Q000294:innervation / Q000378:metabolism*
D007773:Lactates; D014316:Tritium; D009638:Norepinephrine