title: Effect of low concentrations of nitrous oxide and isoflurane on peak velocity of saccadic eye movements.
abstract: Peak velocity of saccadic eye movements was studied in six healthy volunteers who were each given, on separate days, 5% and 10% MAC of nitrous oxide (5% and 10% end-tidal) or of isoflurane (0.06% and 0.12% end-tidal) or air, each gas for 25 min. Subjective assessment following each treatment was also undertaken. No significant difference was found between air and either 5% or 10% nitrous oxide. However, significant differences occurred at 15 and 25 min after 0.06% isoflurane compared with air (P less than 0.05) and highly significant differences were present 5, 15 and 25 min after 0.12% isoflurane when compared with air and nitrous oxide (P less than 0.01). In contrast, there was little difference between the three gases by subjective assessment.
authors.affiliation: Department of Anaesthetics, University of Wales College of Medicine, Heath Park, Cardiff.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.forename: R W
authors.initials: RW
authors.lastname: Marshall
authors.forename: M D
authors.initials: MD
authors.lastname: Vickers
mesh_terms: D000328:Adult; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage*; D009609:Nitrous Oxide / Q000008:administration & dosage*; D012016:Reference Values; D012438:Saccades / Q000187:drug effects*
chemical_list: D007530:Isoflurane; D009609:Nitrous Oxide