Cochleotoxicity of otic drops in the chinchilla: comparative study of Bestron and Cortisporin.
Bestron, a new otic preparation containing cefmenoxime, was applied to the round window membrane of the chinchilla and the long-term cochleotoxicity was evaluated by means of electrocochleography. The thresholds of the compound action potential (CAP) in all frequency areas tested ranged within normal values. The input-output and -latency relationships of the CAP resulted in no significant deterioration of hearing. However, identical treatment with Cortisporin resulted in elevated CAP threshold in the high frequency area and deterioration of the input-output and -latency of the CAP. These findings indicate that Bestron is noncochleotoxic as compared with Cortisporin and therefore may be used safely in the treatment of infected ears.
Ikeda
K
K
Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
Morizono
T
T
Juhn
S K
SK
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D015281:Cefmenoxime / Q000009:adverse effects*; D002682:Chinchilla; D003051:Cochlea / Q000187:drug effects* / Q000502:physiology; D004338:Drug Combinations; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006854:Hydrocortisone / Q000009:adverse effects*; D009355:Neomycin / Q000009:adverse effects*; D011112:Polymyxin B / Q000009:adverse effects*; D012405:Round Window, Ear / Q000187:drug effects
D004338:Drug Combinations; C033225:hydrocortisone, neomycin, polymyxin B drug combination; D009355:Neomycin; D011112:Polymyxin B; D015281:Cefmenoxime; D006854:Hydrocortisone