title: [Thrombolysis with intravenous APSAC in patients with acute myocardial infarction].
abstract: OBJECTIVE
  Analysis of the first 20 patients with acute myocardial infarction (AMI) who were treated with intravenous APSAC.
  
  
  METHODS
  Twenty patients with AMI less than 6 hours of duration of symptoms were treated with IV APSAC bolus of 30 mg. Seventeen were males, ages ranging between 40 and 73 (mean 54) years. The first angiographic study was performed in 90 minutes and 5-7 days after drug administration.
  
  
  RESULTS
  In the angiographic study performed at 90 minutes the infarct--related artery were left anterior descending (LAD) in 7 patients (35%), right coronary artery (RCA) in 9 (45%) and left circumflex (LCX) in 4 (20%). In 14 (70%) of the patients had patent infarct-related artery and the mean of left ventricular ejection fraction (LVEF) was 0.49 +/- 0.15. In six non recanalized patients the mean LVEF was 0.40 +/- 0.14. No complications were observed, and in the second angiographic study one patient showed reocclusion of the infarct-related artery.
  
  
  CONCLUSIONS
  Because of easy application (IV bolus), no complication and high rate of early recanalization, IV APSAC seems to be an efficient thrombolytic agent in the treatment of patients with AMI.
authors.affiliation: Hospital UNICOR-São Paulo.
authors.forename: E
authors.initials: E
authors.lastname: Ribeiro
authors.forename: L A
authors.initials: LA
authors.lastname: Silva
authors.forename: A
authors.initials: A
authors.lastname: Petrizzo
authors.forename: S P
authors.initials: SP
authors.lastname: Torossian
authors.forename: J L
authors.initials: JL
authors.lastname: Oliveira
authors.forename: E
authors.initials: E
authors.lastname: Buffollo
authors.forename: R
authors.initials: R
authors.lastname: Duprat Filho
mesh_terms: D000328:Adult; D000368:Aged; D016255:Anistreplase / Q000008:administration & dosage / Q000627:therapeutic use*; D004630:Emergencies; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D015912:Thrombolytic Therapy
chemical_list: D016255:Anistreplase
vernacular_title: Trombólise com apsac endovenoso em pacientes com infarto agudo do miocárdio.