Preparation of [Arg-Gly-Asp]-[amino-poly(ethylene glycol)] hybrids and their inhibitory effect on experimental metastasis.
Hybrids of a fibronectin-related tripeptide (Arg-Gly-Asp) and amino-poly(ethylene glycol) were prepared and their inhibitory effect on experimental metastasis in mice was examined. The hybrids exhibited a potent inhibitory effect on the metastasis of B16 melanoma BL6.
Kawasaki
K
K
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Namikawa
M
M
Yamashiro
Y
Y
Hama
T
T
Mayumi
T
T
D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008969:Molecular Sequence Data; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D009842:Oligopeptides; C074506:arginyl-glycyl-aspartic acid-(amino-polyethylene glycol); D011092:Polyethylene Glycols