The effect of vitamin E on granulocyte function in patients with recurrent infections.
The influence of vit. E treatment on metabolic and bactericidal granulocyte activity in patients with recurrent infections was studied by chemiluminescence and phagocytosis assays. Vit. E serum level was significantly diminished before therapy. Six weeks supplementation with 200-300 mg/day of vit. E resulted in improvement of clinical status and normalisation of alpha-tocopherol serum level. Bactericidal activity of granulocytes was lower in patients than in the respective controls and it slightly rose after vit. E therapy. Before, therapy, patients granulocytes showed metabolic activity above or within the control range. Vit. E treatment increased, had no effect or decreased granulocyte metabolic activity, but never below the control range.
Małkowska-Zwierz
W
W
Medical Center of Postgraduate Education, Warsaw, Poland.
Garliński
P
P
Zukowska
M
M
Zabuska
K
K
Wartanowicz
M
M
Kleniewska
D
D
Niemirowska
H
H
Izdebska
Z
Z
Roszkowski
W
W
Wróblewski
T
T
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D001770:Blood Bactericidal Activity / Q000187:drug effects; D005260:Female; D005609:Free Radicals; D006098:Granulocytes / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D012008:Recurrence; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000150:complications / Q000503:physiopathology
D005609:Free Radicals; D014810:Vitamin E; D010100:Oxygen