[Role of the patho-autokinetic element in the pathogenesis of disturbances of myocardial lipid composition induced by experimental atherogenic dyslipoproteinemia].
The lipid and phospholipid composition of the myocardium and mitochondria of cardiac myocytes of rabbits was studied after correction of atherogenic dyslipoproteinemia induced by intravenous infusion of atherogenic lipoproteins. Discontinuation of lipoprotein infusions and subsequent normalization of the blood lipoprotein spectrum was not attended by removal of lipidosis of the cardiac muscle characteristic of hyperlipoproteinemia. The disturbance of the lipid composition of the mitochondria of the cardiac myocytes also persisted after disappearance of atherogenic dyslipoproteinemia. The results of the study provide evidence of the existence of a patho-autokinetic element of the pathogenesis of disturbances of myocardial lipid metabolism occurring in atherogenesis.
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D000818:Animals; D004036:Diet, Atherogenic; D006951:Hyperlipoproteinemias / Q000378:metabolism*; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D009068:Movement / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011817:Rabbits
D010743:Phospholipids
Rol' patoautokineticheskogo élementa v patogeneze narusheniĭ lipidnogo sostava miokarda, indutsirovannykh éksperimental'noĭ aterogennoĭ dislipoproteidemieĭ.