title: [Association of sporadic limb-girdle muscular dystrophy and autonomous thyroid nodule in 3 Germans].
abstract: The paper reports an association of limb-girdle muscular dystrophy and autonomous functioning thyroid nodule in two brothers and in one sister, a healthy carrier of this muscular dystrophy and with analogous thyroid pathology. It is interesting to outline the rarity of this association and the affinity of the clinical and electromyography pictures in thyrotoxic myopathy and in muscular dystrophy. In this three patients were studied: the muscular enzymes, electromyography and biopsy, HLA typing, thyroid scanning, thyroid hormone levels and TGA and TMA antibodies. However, the peculiarity of this case report may suggest the influence of genetic factors; moreover the existence of possible linkage between HLA system and association of two pathologies must be excluded, taking in account that the results of HLA types in these three Germans indicate different haplotypes.
authors.affiliation: Cattedra di Endocrinologia, Università degli Studi di Napoli.
authors.forename: L
authors.initials: L
authors.lastname: Di Lorenzo
authors.forename: G
authors.initials: G
authors.lastname: Lupoli
authors.forename: E
authors.initials: E
authors.lastname: Cosentini
authors.forename: P G
authors.initials: PG
authors.lastname: Rippa
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D004576:Electromyography; D005260:Female; D005858:Germany / Q000208:ethnology; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015994:Incidence; D008297:Male; D009124:Muscle Proteins / Q000032:analysis; D009132:Muscles / Q000201:enzymology; D009136:Muscular Dystrophies / Q000145:classification / Q000150:complications* / Q000235:genetics; D013963:Thyroid Hormones / Q000097:blood; D016606:Thyroid Nodule / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D013973:Thyrotropin-Releasing Hormone
chemical_list: D001323:Autoantibodies; D006680:HLA Antigens; D009124:Muscle Proteins; D013963:Thyroid Hormones; D013973:Thyrotropin-Releasing Hormone
vernacular_title: Associazione di sporadica distrofia muscolare dei cingoli e nodulo tiroideo autonomo in tre germani.