Potentiation of acetaldehyde-induced vasoconstrictions by cocaine in isolated and perfused arteries.
Vasoconstrictor responses to acetaldehyde (AA), norepinephrine (NE) and tyramine were investigated in isolated, perfused canine intermediate auricular (ear) arteries. Single injections of small doses of AA (1-3 mumol) induced a vasoconstriction in a dose-related manner and showed no tachyphylaxis. Cocaine significantly inhibited tyramine-induced vasoconstrictions, but NE- and AA-induced vasoconstrictions were rather significantly enhanced.
Chiba
S
S
Department of Pharmacology, Shinshu University School of Medicine.
Tsukada
M
M
D000079:Acetaldehyde / Q000008:administration & dosage*; D000818:Animals; D003042:Cocaine / Q000008:administration & dosage*; D004285:Dogs; D004357:Drug Synergism; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000008:administration & dosage; D010477:Perfusion; D014439:Tyramine / Q000008:administration & dosage; D014661:Vasoconstriction / Q000187:drug effects*
D000079:Acetaldehyde; D003042:Cocaine; D009638:Norepinephrine; D014439:Tyramine