Comparative study "in vitro" of transdermal absorption of a series of antiemetic drugs.
The "in vitro" transdermal absorption characteristics of various antiemetic drugs (Alizapride, Bromopride, Clebopride, Domperidone, Metoclopramide, Metopimazine) were studied. Franz diffusion glass cells were used. The skin of hairless rat was used as a permeation membrane. The following parameters were evaluated for each drug: Permeation constant (Kp), lag time (T1), and flux (J). A comparative study of permeation characteristics of the assayed drugs was carried out. Their potential use as transdermal dosage forme was also studied. Based on the results, Bromopride and Clebopride have showed the best "in vitro" permeation profile to be used by transdermal administration.
Blanes
C
C
Department of Pharmacy, University of Barcelona, Spain.
Colom
H
H
Moreno
J
J
Obach
R
R
Peraire
C
C
Domenech
J
J
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D000932:Antiemetics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D012869:Skin Absorption; D013056:Spectrophotometry, Ultraviolet
D000932:Antiemetics