title: [Side effects and toxicity of new quinolones].
abstract: A review paper is presented treating of problems of organotoxicity, mutagenicity, carcinogenicity and adverse effects of quinolones, as well as their interaction with other drugs. Not considering some rather sporadic exceptions, quinolones are not regarded as safe in children up to the age of 14 and in pregnant and breast-feeding women. Compared to aminoglycosides, tetracycline, chloramphenicol, rifampicin and other antibacterial chemotherapeutics, the overall toxicity of quinolones is relatively low. The questions of adverse effects upon the intestinal microflora and of tolerance of novel quinolones are also addressed. With regard to the above mentioned aspects, ofloxanice, ciprofloxacine, enoxacine, pefloxacine, norfloxacine, and fleroxacine have been most thoroughly studied. For the other recently developed quinolones reliable information is scarce. (Tab. 2, Ref. 53).
authors.affiliation: Katedra klinickej onkológie ILF v Bratislave.
authors.forename: V
authors.initials: V
authors.lastname: Krcméry
authors.forename: P
authors.initials: P
authors.lastname: Cepcek
mesh_terms: D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects*; D006801:Humans
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents
vernacular_title: Vedl'ajsie neziadúce úcinky a toxicita novsích chinolónov.