Antitoxic properties of a preparation of glutathione S-transferase.
Pretreatment of rats with a preparation of the cationic form of rat liver cytosolic glutathione S-transferase 1-3 h before injection of a dose of N-nitroso-N-diethylamine equivalent to the LD50 of the drug completely protects the animals against the toxic effects of the drug. The mechanism of the protective action of glutathione S-transferase is discussed.
Kalinina
E V
EV
All-Union Research Institute of Biotechnology, Ministry of Medical Industry of the USSR, Moscow.
Nechaev
V N
VN
Saprin
A N
AN
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003600:Cytosol / Q000201:enzymology; D004052:Diethylnitrosamine / Q000633:toxicity; D005982:Glutathione Transferase / Q000627:therapeutic use*; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D004052:Diethylnitrosamine; D005982:Glutathione Transferase