Chemosensitivity spectrum of a human pleural mesothelioma xenograft grown in athymic rats.
A human pleural mesothelioma tumour line (AKG) serially transplantable as a subcutaneously growing xenograft in athymic rats was evaluated for chemosensitivity to six antitumour drugs. Drug effects were assessed as the reduction of the area under the tumour volume curve (1-AUC) and as specific growth delay (SGD), resulting from the maximum tolerable dose (MTD) intraperitoneally in athymic rats. SGD greater than 2 or (1-AUC) greater than 0.85 were used as criteria of an active drug at the MTD. Etoposide (40 mg/kg), vincristine (0.9 mg/kg) and vindesine (0.8 mg/kg) were found to be inactive. Cisplatin (CDDP; 8 mg/kg) and carmustine (BCNU; 40 mg/kg) were found to be active resulting in (1-AUC)s of 1.04 and 0.88, respectively. Although mitomycin C (MC) at the MTD of 1.8 mg/kg resulted in a (1-AUC) of only 0.81, the SGD at a dose of 1.5 mg/kg was greater than 2 and therefore the drug was regarded as active. Furthermore, a combination of CDDP 3 mg/kg and MC 1.25 mg/kg was found to be active resulting in (1-AUC) = 0.90 and SGD = 4.70. The combination of CDDP and MC seems to be a promising regime warranting further studies.
Lindén
C J
CJ
Department of Lung Medicine, University Hospital, Lund, Sweden.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002330:Carmustine / Q000494:pharmacology; D002945:Cisplatin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D008654:Mesothelioma / Q000188:drug therapy*; D016685:Mitomycin / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010997:Pleural Neoplasms / Q000188:drug therapy; D051381:Rats; D011923:Rats, Nude; D014183:Transplantation, Heterologous; D014750:Vincristine / Q000494:pharmacology; D014751:Vindesine / Q000494:pharmacology
D000970:Antineoplastic Agents; D016685:Mitomycin; D014750:Vincristine; D005047:Etoposide; D002945:Cisplatin; D014751:Vindesine; D002330:Carmustine