Technological aspect of the production of live dysentery vaccines for oral administration.
An experimental technology for the production of live freeze-dried vaccines prepared from attenuated Shigella flexneri 2a and Shigella sonnei I strains was developed. It is based on the cultivation of bacterial strains in a fermentor under conditions which ensure high yields. The strains grow in S-form, their antigenic structure is preserved and they remain non-virulent. The attenuating markers are stable. The freeze-dried vaccines retain good immunogenicity when applied intra-intestinally to rats.
Denchev
V
V
Institute of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Nenkov
P
P
Vitanov
T
T
Sumerska
T
T
Marinova
S
S
Vassilev
T
T
Panova
I
I
Bratoeva
M
M
Linde
K
K
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D004405:Dysentery, Bacillary / Q000276:immunology*; D005612:Freeze Drying; D006168:Guinea Pigs; D051381:Rats; D012763:Shigella flexneri / Q000254:growth & development / Q000276:immunology*; D012764:Shigella sonnei / Q000254:growth & development / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated