title: Bovine milk, including pasteurised milk, contains antibodies directed against allergens of clinical importance to man.
abstract: Pasteurised and raw bovine milk and bovine colostrum samples were assayed by enzyme-linked immunoassay for the presence of antibodies directed against a selection of allergens of importance in human atopic disease. Samples were tested for the presence of antibodies directed against or cross-reacting with ryegrass pollen, house dust mites, Aspergillus mould and wheat proteins. Antibodies of each specificity were detected in every sample tested, including all samples of commercial pasteurised milk. The results are discussed with reference to a hypothesis that dietary xenogeneic antibodies may play a role in the emergence of some human atopic disease, and the recent demonstration that oral immunisation with xenogeneic antibodies may lead to the production of anti-immunoglobulin antibodies including anti-idiotypic antibodies.
authors.affiliation: Royal Children's Hospital, Melbourne, Australia.
authors.forename: A M
authors.initials: AM
authors.lastname: Collins
authors.forename: D M
authors.initials: DM
authors.lastname: Roberton
authors.forename: C S
authors.initials: CS
authors.lastname: Hosking
authors.forename: G R
authors.initials: GR
authors.lastname: Flannery
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity; D000946:Antigens, Fungal / Q000276:immunology; D001230:Aspergillus / Q000276:immunology; D003126:Colostrum / Q000276:immunology; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D006969:Hypersensitivity, Immediate / Q000276:immunology; D008892:Milk / Q000276:immunology*; D008925:Mites / Q000276:immunology; D010940:Plant Proteins / Q000276:immunology; D011058:Pollen / Q000276:immunology; D014908:Triticum
chemical_list: D000485:Allergens; D000906:Antibodies; D000946:Antigens, Fungal; D010940:Plant Proteins