Effect of steroids on the cytochrome P4502D6-catalysed metabolism of metoprolol.
Pepper
J M
JM
University Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, UK.
Lennard
M S
MS
Tucker
G T
GT
Woods
H F
HF
D000818:Animals; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism*; D004054:Diethylstilbestrol / Q000494:pharmacology; D006801:Humans; D006900:Hydroxylation / Q000187:drug effects; D008297:Male; D008790:Metoprolol / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013256:Steroids / Q000494:pharmacology*
D013256:Steroids; D004054:Diethylstilbestrol; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6; D008790:Metoprolol