Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot.
Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocites. In fibroids from treated patients the histochemical score (HSCORE) of vessel cells was always significantly lower (p less than 0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.
Leone
M
M
Department of Obstetrics and Gynecology, University of Genoa, Italy.
Cucuccio
S
S
Venturini
P L
PL
Valenzano-Menada
M
M
Messeni Leone
M
M
De Cecco
L
L
D000328:Adult; D002064:Buserelin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D017273:Goserelin; D006801:Humans; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000648:ultrastructure*; D008875:Middle Aged; D009215:Myometrium / Q000737:chemistry / Q000187:drug effects / Q000648:ultrastructure; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000648:ultrastructure*
D003692:Delayed-Action Preparations; D017273:Goserelin; D066246:ErbB Receptors; D002064:Buserelin