In vitro activity of azithromycin against clinical isolates of Legionella species.
The activities of azithromycin, erythromycin, and ciprofloxacin against 21 Legionella isolates were measured by an agar dilution method and in macrophages. The MICs for 90% of strains tested were 2.0, 1.0, and 0.5 micrograms/ml for azithromycin, erythromycin, and ciprofloxacin, respectively. Azithromycin and ciprofloxacin were both bactericidal in the macrophage system, but erythromycin was bacteriostatic.
Edelstein
P H
PH
Department of Pathology, University of Pennsylvania, School of Medicine, Philadelphia 19104-4283.
Edelstein
M A
MA
D000818:Animals; D017963:Azithromycin; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D007875:Legionella / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D011650:Pulmonary Alveoli / Q000166:cytology
D004917:Erythromycin; D017963:Azithromycin