Suppressive effects of dehydroepiandrosterone and 3 beta-methyl-androst-5-en-17-one on attack towards lactating female intruders by castrated male mice. II. Brain neurosteroids.
Dehydroepiandrosterone (DHA) and 3 beta-methyl-androst-5-en-17-one (CH3-DHA) suppress attacks by castrated male mice towards lactating female intruders (Haug et al. Physiol. Behav. 46:955, 1989). Their effects on the concentrations of DHA, pregnenolone (delta 5P), and their sulfate ester (S) have been investigated in the brain of control and treated mice. A more than 2 fold, significant, decrease of delta 5P-S was the only change common to both steroids. DHA and CH3-DHA effects might be related to the antagonistic action of delta 5P-S on GABAA receptors.
Young
J
J
INSERM U33, Lab. Hormones, Bicêtre, France.
Corpéchot
C
C
Haug
M
M
Gobaille
S
S
Baulieu
E E
EE
Robel
P
P
D000374:Aggression / Q000187:drug effects*; D000736:Androstenes / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D007774:Lactation; D008297:Male; D051379:Mice; D009919:Orchiectomy; D011284:Pregnenolone / Q000378:metabolism; D013256:Steroids / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism
D000736:Androstenes; D013256:Steroids; D013739:Testosterone; D003687:Dehydroepiandrosterone; D011284:Pregnenolone; C040993:3-methylandrost-5-en-17-one