title: Anaerobic pathogenesis: collagenase production by Peptostreptococcus magnus and its relationship to site of infection.
abstract: Fifty isolates of Peptostreptococcus magnus from intraabdominal sepsis, nonpuerperal breast abscess, and diabetic foot infections were examined for collagenase activity using bovine type I collagen. Collagenase production was detected in a higher percentage of strains from nonpuerperal breast and diabetic foot specimens (P less than .001). This enzyme may be responsible for P. magnus playing a more central role in the pathogenesis of nonpuerperal breast abscess and diabetic foot disease than in intraabdominal sepsis.
authors.affiliation: Surgical Microbiology Research Laboratory, Medical College of Wisconsin, Milwaukee 53226.
authors.forename: C J
authors.initials: CJ
authors.lastname: Krepel
authors.forename: C M
authors.initials: CM
authors.lastname: Gohr
authors.forename: C E
authors.initials: CE
authors.lastname: Edmiston
authors.forename: S G
authors.initials: SG
authors.lastname: Farmer
mesh_terms: D000038:Abscess / Q000382:microbiology; D001424:Bacterial Infections / Q000382:microbiology*; D001941:Breast Diseases / Q000382:microbiology; D003094:Collagen / Q000378:metabolism; D048909:Diabetes Complications; D005534:Foot Diseases / Q000209:etiology / Q000382:microbiology; D006801:Humans; D003012:Microbial Collagenase / Q000096:biosynthesis*; D010462:Peptostreptococcus / Q000201:enzymology* / Q000302:isolation & purification; D010538:Peritonitis / Q000382:microbiology
chemical_list: D003094:Collagen; D003012:Microbial Collagenase