Diet-induced changes in glucose and triglycerides are associated with changes in plasminogen activator inhibitor levels.
Twenty-four healthy female subjects volunteered to participate in an experiment in which they maintained a high-fat/low-carbohydrate (CHO) diet followed by a low-fat/high-CHO diet or vice versa in a cross-over study design. In bivariate correlation analysis, only glucose (r = 0.52, p less than 0.05) and triglycerides (r = 0.53, p less than 0.05) correlated with changes in plasminogen activator inhibitor type 1 (PAI-1) activity. A second-degree polynomial response surface model suggested that transition from a high-fat/low-CHO diet to a low-fat/high-CHO diet is associated with reduced levels of PAI-1 provided that glucose and triglyceride levels are not elevated by more than 1.2 and 0.5 mmol/l, respectively.
Sundell
I B
IB
Department of Pathology, University of Umeå, Sweden.
Dahlén
G H
GH
Rånby
M
M
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D017270:Lipoprotein(a); D008074:Lipoproteins / Q000097:blood; D010958:Plasminogen / Q000378:metabolism; D015849:Plasminogen Inactivators / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000276:immunology
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D007328:Insulin; D008055:Lipids; D017270:Lipoprotein(a); D008074:Lipoproteins; D015849:Plasminogen Inactivators; D010958:Plasminogen; D010959:Tissue Plasminogen Activator; D006854:Hydrocortisone