title: Differential distribution of the mRNA encoding two isoforms of the catalytic subunit of calcineurin in the rat brain.
abstract: The distribution of mRNAs encoding two distinct isoforms of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A), designated calcineurin A alpha and A beta, in the rat brain was examined by using Northern blots and in situ hybridization histochemistry. The mRNAs for calcineurin A alpha and A beta were both unevenly present in the brain and showed different distribution. The differential distribution between calcineurin A alpha and A beta messages suggests that the individual isoforms are involved in specialized neural functions.
authors.affiliation: Department of Pharmacology, Kobe University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takaishi
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Kuno
authors.forename: C
authors.initials: C
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D008297:Male; D010749:Phosphoprotein Phosphatases / Q000096:biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013462:Sulfur Radioisotopes
chemical_list: D002148:Calmodulin-Binding Proteins; D012333:RNA, Messenger; D013462:Sulfur Radioisotopes; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases