[Cardiac transplantation: economizing cyclosporin A by including ketoconazole in the immunosuppressive schedule].
Use of cyclosporin A has improved survival in patients submitted to cardiac transplantation. However, high cost of cyclosporin poses a problem for many patients in Chile. Ketoconazole is able to reduce hepatic metabolism of cyclosporin and thus prolong therapeutic levels. A 74 to 82% reduction in cyclosporin requirements was obtained in a cardiac transplant patient by adding ketoconazole. No renal damage was detected. Therefore, this drug association may help extend cardiac transplantation programs in Chile.
Becerra
E
E
Servicio de Cirugía Cardiovascular, Hospital Dr Gustavo Fricke, Viña del Mar, Chile.
Aranguiz
E
E
Pedemonte
O
O
De Prada
M T
MT
Merello
L
L
Orfali
C
C
Aninat
M
M
Torres
H
H
González
R
R
Chadid
P
P
D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008297:Male
D016572:Cyclosporine; D007654:Ketoconazole
Trasplante cardíaco: ahorro de ciclosporina "A" mediante la asociación de ketoconazol al esquema inmunosupresor.