The effects of long-term treatment with 8-OH-DPAT on the lordosis response and hypothermia in female rats.
The effects of long-term treatment with a low dose of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on steroid hormone-dependent copulatory behaviour in female rats, the lordosis response, and on the hypothermic response of female rats were studied. Female rats were treated for 15 days, once daily, and tested on days 1 and 15 of treatment. They received 25 micrograms/kg on test days and 50 micrograms/kg on all other days. Subsensitivity was not induced to the inhibitory effect of 8-OH-DPAT on the lordosis response. In contrast, however, the acute effect of 8-OH-DPAT on body temperature was abolished by the long-term treatment. The results presented indicate that the induction of subsensitivity to the effects of 8-OH-DPAT is not primarily dependent on the pre- or post synaptic locus of action. Our data suggest that hormonal mechanisms are involved.
Johansson
C E
CE
Department of Medical Pharmacology, Uppsala University, Sweden.
Meyerson
B J
BJ
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D004361:Drug Tolerance; D005260:Female; D007035:Hypothermia / Q000139:chemically induced* / Q000503:physiopathology; D011187:Posture; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin