Selective thromboxane synthase inhibition does not increase in vivo synthesis of prostacyclin in healthy humans.
Vesterqvist
O
O
Department of Clinical Chemistry and Blood Coagulation, Karolinska Hospital, Stockholm, Sweden.
Gréen
K
K
Henriksson
P
P
Rasmanis
G
G
Edhag
O
O
D011464:Epoprostenol / Q000096:biosynthesis*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D011725:Pyridines / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000096:biosynthesis; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D007093:Imidazoles; D011725:Pyridines; D013928:Thromboxane A2; C037787:pirmagrel; D011464:Epoprostenol; D013930:Thromboxane-A Synthase