title: [The enzymatic chemical mechanisms of adaptation].
abstract: In sheep from biogeochemical provinces enriched by molybdenum and copper and in a model form of molybdenum toxicosis in animals, the important role of enzymic and neurohumoral systems in the development of adaptation to excessive uptake of molybdenum and copper has been demonstrated. Adaptive reorganization of the activity of enzymic systems (xanthine oxidase, ceruloplasmin, succinate dehydrogenase, aspartate and alanine aminotransferases) and gradual involvement of neurohumoral mechanisms of the sympathoadrenal and cholinoreactive systems provide for adaptation of some animals in molybdenum and copper-molybdenum biogeochemical provinces. In other sheep, under the same conditions, dystonic disturbances in the vegetative nervous systems are observed together with the development of molybdenum toxicosis.
authors.forename: M S
authors.initials: MS
authors.lastname: Grigorian
authors.forename: L G
authors.initials: LG
authors.lastname: Tatevosian
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001136:Armenia; D003300:Copper / Q000009:adverse effects; D004781:Environmental Exposure / Q000009:adverse effects; D004798:Enzymes / Q000097:blood* / Q000187:drug effects; D008982:Molybdenum / Q000009:adverse effects / Q000506:poisoning; D011041:Poisoning / Q000201:enzymology / Q000503:physiopathology / Q000662:veterinary; D012621:Seasons; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced / Q000201:enzymology / Q000503:physiopathology
chemical_list: D004798:Enzymes; D003300:Copper; D008982:Molybdenum
vernacular_title: K voprosu o nekotorykh énzimokhimicheskikh mekhanizmakh adaptatsii.