Biology and chemistry of low affinity IgE receptor (Fc epsilon RII/CD23).
Recent studies have established that the low affinity Fc receptor for IgE (Fc epsilon RII/CD23) is a structurally and functionally unique immunoglobulin receptor. DNA sequence analysis predicts that, in contrast to other FcR, Fc epsilon RII is not a member of the immunoglobulin gene superfamily and, indeed, is inserted into the membrane in opposite orientation from most other membrane proteins. While the Fc epsilon RII of macrophages, eosinophils, and platelets mediate IgE-dependent cytotoxicity and promote phagocytosis of IgE-antigen complexes, the function of Fc epsilon RII on B lymphocytes remains unclear. Much effort has been directed toward establishment of its role in IgE regulation, but the plurality of B cell Fc epsilon RII expression, i.e. greater than 90% of the mu + /delta + B lymphocytes, is incongruous with simply a role in regulating only IgE responses. Hence, the discovery that Fc epsilon RII is identical to the B-cell activation antigen, CD23, together with its novel structural features, suggests an additional more important role for this interesting protein and would explain the disparity between a commonly expressed receptor with apparently limited functions.
Richards
M L
ML
Division of Immunology, Medical Biology Institute, La Jolla, CA 92037.
Katz
D H
DH
D015703:Antigens, CD / Q000737:chemistry* / Q000235:genetics; D000944:Antigens, Differentiation, B-Lymphocyte / Q000737:chemistry* / Q000235:genetics; D001483:Base Sequence; D005803:Genes, Immunoglobulin; D007073:Immunoglobulin E / Q000737:chemistry* / Q000235:genetics; D016130:Immunophenotyping; D008214:Lymphocytes / Q000276:immunology; D008969:Molecular Sequence Data; D011961:Receptors, Fc / Q000737:chemistry* / Q000235:genetics; D017455:Receptors, IgE
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E