title: [Effect of alpha-human atrial natriuretic factor on isolated myocardial contractile force and action potential duration in guinea pigs].
abstract: The effect of alpha-hANF on contractile force and action potential duration (APD) of isolated myocardium in guinea pig was investigated. At the level of 20 nmol/L and 40 nmol/L alpha-hANF, the contraction amplitude and rate of contraction phase decreased to a remarkable extent. And at 40 nmol/L, APDs were shortened significantly 20 min after alpha-hANF. The results suggest that there exists a direct inhibitory effect of alpha-hANF on myocardial contractile force and action potential duration.
authors.affiliation: Section of Physiology, Zhoushan Health School, Zhejiang.
authors.forename: W J
authors.initials: WJ
authors.lastname: Wu
authors.forename: Q A
authors.initials: QA
authors.lastname: Xia
mesh_terms: D000200:Action Potentials; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D010210:Papillary Muscles / Q000502:physiology
chemical_list: C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor