title: Stage I-II carcinoma of the anterior two-thirds of the tongue treated with different modalities: a retrospective analysis of 244 patients.
abstract: Treatment results of 244 patients with stage I-II cancer of the mobile tongue were analyzed according to the modalities employed (implantation, surgery, cryosurgery and intraoral irradiation). Overall local control rates at three years were 90 +/- 3% for implant, 89 +/- 7% for cryosurgery, and 84 +/- 9% for surgery. Local control rates in stage II patients treated with intraoral electron irradiation, however, were only 50 +/- 13%. Five-year survival rates were 72 +/- 3% with no significant differences observed in patients with either stage I or stage II regardless of treatment modality. Sixty percent (29/48) of the patients with local recurrences were salvaged by the second treatment. Since the local control and survival achieved by these modalities were similar, with the exception of patients with stage II treated by intraoral electron irradiation, we recommend interstitial implantation with iridium, intraoral electron irradiation or surgery for patients with T1 tumors, and iridium implantation or surgery for patients with T2 tumors. For those with superficial lesions measuring 5 mm or less in thickness, cryosurgery is being offered as an alternative. The patient can choose the treatment modality taking into account his/her age, sex and profession.
authors.affiliation: Department of Radiation Therapy, National Cancer Center, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Akine
authors.forename: N
authors.initials: N
authors.lastname: Tokita
authors.forename: T
authors.initials: T
authors.lastname: Ogino
authors.forename: I
authors.initials: I
authors.lastname: Tsukiyama
authors.forename: S
authors.initials: S
authors.lastname: Egawa
authors.forename: M
authors.initials: M
authors.lastname: Saikawa
authors.forename: W
authors.initials: W
authors.lastname: Ohyama
authors.forename: T
authors.initials: T
authors.lastname: Yoshizumi
authors.forename: S
authors.initials: S
authors.lastname: Ebihara
mesh_terms: D003131:Combined Modality Therapy; D003452:Cryosurgery; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007564:Japan; D009367:Neoplasm Staging; D011832:Radiation Injuries / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000473:pathology / Q000628:therapy*