Astrocytes: a possible primary site for colchicine-mediated neurotoxicity in the rat striatum.
Ultrastructural changes in rat astrocytes including endfoot swelling and rupture of plasma membranes were seen as early as 1 h after injection of 6.0 micrograms colchicine (CO) into the striatum. Significant change in neuronal morphology was not seen by 24 h. Astrocytes may therefore be primary targets for CO-mediated damage, which then may have secondary neurotoxic consequences.
Pitts
O M
OM
Ensor Laboratory, William S. Hall Psychiatric Institute, Columbia, South Carolina 29202.
Cohen
M R
MR
McAmis
W
W
Gutman
R L
RL
D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000648:ultrastructure; D003078:Colchicine / Q000633:toxicity*; D003342:Corpus Striatum / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D003078:Colchicine