Synthesis and interaction studies of oligo and polyamino acids derivatives containing nucleosides.
Nucleic acid analogs of L-lysine derivatives containing uridine and/or adenosine were synthesized. As dimer models, Lys(Urd)-Lys(Urd) and Lys(Urd)-Lys(Ado) were prepared by activated ester method. These dimers were found to form complex with Poly A, which was observed from hypochromicity of UV spectra. Furthermore poly-L-lysine derivative containing uridine was also prepared. The maximum hypochromicity value of this polymer model with PolyA was higher than that of dimer models.
Wada
T
T
Faculty of Engineering, Osaka University, Japan.
Mochizuki
E
E
Inaki
Y
Y
Takemoto
K
K
D000241:Adenosine / Q000737:chemistry*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D011107:Polylysine / Q000737:chemistry*; D011108:Polymers; D014529:Uridine / Q000737:chemistry*
D009705:Nucleosides; D011108:Polymers; D011107:Polylysine; D000241:Adenosine; D014529:Uridine