[The action of 3-indolepyruvate in quinolinate-induced convulsions in mice].
The experiments on 286 mice of two lines (SHR and C57BL/6) showed that 3-indoipyruvate, a natural keto analogue of tryptophan and a precursor of serotonin and kynurenic acid) possesses the selective dose-dependent (100-500 mg/kg, intraperitoneally) protective effect against quinolinate-induced convulsions. At prolonged administration (50-100 mg/kg for 10 days twice a day) its efficiency drastically increased. It is supposed that the mechanism of the anticonvulsant action of 3-indolpyruvate involves an enhancement of synthesis of kynurenic acid, a blocker of N-methyl-D-aspartate receptors, and at chronic administration--also an increase of sensitivity and density of these receptors.
Mirzaev
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Ryzhov
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D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010433:Pentylenetetrazole; D017378:Quinolinic Acid; D011805:Quinolinic Acids; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013997:Time Factors
D000927:Anticonvulsants; D003292:Convulsants; D007211:Indoles; D011805:Quinolinic Acids; C008122:indol-3-yl pyruvic acid; D017378:Quinolinic Acid; D010433:Pentylenetetrazole
Deĭstvie 3-indolpiruvata pri khinolinatnykh sudorogakh u mysheĭ.