title: Decreased oxidant-induced proteolysis in erythrocytes with enhanced antioxidative defence enzymes due to Down's syndrome.
abstract: Erythrocytes of Down syndrome patients, having increased activity of superoxide dismutase and glutathione peroxidase, showed a similar increase in intracellular proteolysis upon stimulation with 1 mmol/l phenylhydrazine than normal erythrocytes. There were no differences in the magnitude of Heinz body formation following the treatment or in the proteolysis of exogenous oxidized substrate. These results demonstrate a protective role for endogenous antioxidative enzymes in the protein damage by oxidative stress which triggers intracellular proteolysis.
authors.affiliation: Department of Biophysics, University of Lódź, Poland.
authors.forename: G
authors.initials: G
authors.lastname: Bartosz
authors.forename: J
authors.initials: J
authors.lastname: Kedziora
authors.forename: W
authors.initials: W
authors.lastname: Retelewska
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D004314:Down Syndrome / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006366:Heinz Bodies / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D010084:Oxidation-Reduction; D010659:Phenylhydrazines / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D001798:Blood Proteins; D010659:Phenylhydrazines; C030299:phenylhydrazine; C006384:N(1)-acetylphenylhydrazine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase