Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart.
Baccharis triptera Mart, is a widespread Compositae used in Brazilian folk medicine to treat gastrointestinal disturbances, rheumatic disease, mild fever, diabetes and as an anti-helminthic. Water extract of small branches of the plant (WE) administered to mice and rats (0.1 to 2 g/kg, p.o.) did not alter spontaneous motor activity, sleeping time induced by barbiturates or the tail-flick response in mice. The extract decreased by 40% the number of writhings induced by 0.8% acetic acid, i.p., but did not influence paw edema induced by carrageenan or dextran in rats. WE (2 g/kg, p.o.) decreased the intestinal transit of charcoal in mice by 20%. Gastric secretion in pylorus ligated rats was reduced after treatment with WE (1 and 2 g/kg, i.p. or intraduodenal) and the gastric pH was raised. The extract (1 g/kg, p.o.) prevented gastric ulcers induced in rats by immobilization at 4 degrees C, but not those induced by indomethacin (10 mg/kg, s.c.). The results indicate that WE may relieve gastrointestinal disorders by reducing acid secretion and gastrointestinal hiperactivity. Neither analgesic nor anti-inflammatory activities were detectable.
Gamberini
M T
MT
Escola Paulista de Medicina Departamento de Farmacologia INFAR, São Paulo, Brasil.
Skorupa
L A
LA
Souccar
C
C
Lapa
A J
AJ
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000930:Antidiarrheals / Q000494:pharmacology; D001938:Brazil; D004353:Drug Evaluation, Preclinical; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010276:Parasympatholytics / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000930:Antidiarrheals; D005765:Gastrointestinal Agents; D010276:Parasympatholytics; D010936:Plant Extracts