title: [Preliminary experience with achieving immune tolerance in patients with hemophilia A and circulating factor VIII inhibitor].
abstract: The appearance of antibodies to factor VIII is a serious complication in the treatment of haemophilia A. A protocol is presented aiming at suppression of the anticoagulant using continued treatment with factor VIII (25 u/kg b.w. twice weekly). Ten patients with previous maximal factor VIII antibody titre from 7 to 2900 Bethesda units were treated. So far the inhibitor was eradicated in 3 cases treated continuously for from 5 to 20 months. In two of these three cases successful surgical procedures were performed without anamnestic response.
authors.affiliation: Klinika Chirurgiczna, Instytut Hematologii, Warszawa.
authors.forename: R
authors.initials: R
authors.lastname: Scharf
authors.forename: W
authors.initials: W
authors.lastname: Kucharski
authors.forename: S
authors.initials: S
authors.lastname: Lopaciuk
authors.forename: W
authors.initials: W
authors.lastname: Celińska
authors.forename: A
authors.initials: A
authors.lastname: Dmytrow
authors.forename: K
authors.initials: K
authors.lastname: Domański
authors.forename: S
authors.initials: S
authors.lastname: Gonet
authors.forename: Z
authors.initials: Z
authors.lastname: Miastkowski
authors.forename: I
authors.initials: I
authors.lastname: Nowakowska
authors.forename: A
authors.initials: A
authors.lastname: Przybylski
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology* / Q000628:therapy; D001803:Blood Transfusion; D002648:Child; D005169:Factor VIII / Q000008:administration & dosage* / Q000276:immunology*; D005340:Fibrinogen / Q000008:administration & dosage*; D006467:Hemophilia A / Q000097:blood / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008297:Male; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; C026912:cryoprecipitate coagulum; D005169:Factor VIII; D005340:Fibrinogen
vernacular_title: Wstepne doświadczenia w uzyskiwaniu tolerancji immunologicznej u chorych na hemofilie A z krazacym antykoagulantem.