[Loss of heterozygosis on the short arm of chromosome 3. Question of the encoding gene for thyroid hormone receptor].
Prognosis of breast tumor patients is not clearly-defined. New marker should be useful. A new field of investigation concerns genetic abnormalities in breast tumors. Oncongene amplification and loss of heterozygosity are the most common alterations. 30% of breast tumors show a loss of heterozygosity on chromosome 3p, where thyroïd hormone receptor, c-erbA-beta is localised. We suggest a potential role for this genetic alteration in breast tumorigenesis.
Lidereau
R
R
Laboratoire d'Oncovirologie, Centre René Huguenin, St-Cloud.
D001943:Breast Neoplasms / Q000235:genetics / Q000503:physiopathology; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D005815:Genetic Code; D006579:Heterozygote; D006801:Humans; D011379:Prognosis; D011988:Receptors, Thyroid Hormone / Q000235:genetics*
D011988:Receptors, Thyroid Hormone
Pertes d'hétérozygotie sur le petit bras du chromosome 3. Mise en cause du gène codant pour un récepteur d'hormone thyroïdienne.