Dietary cholesterol and incidence of lung cancer: the Western Electric Study.
The hypothesis that dietary cholesterol is positively associated with lung cancer was investigated in a 24-year cohort study of 1,878 middle-aged men who were employed in 1958 by the Western Electric Company in Chicago. The relative risk of lung cancer associated with an increment in dietary cholesterol of 500 mg/day was 1.9 (95 percent confidence interval 1.1-3.4) after adjustment for cigarettes, age, and intake of beta-carotene and fat. Results suggested that the association was specific to cholesterol from eggs. Further research is needed to understand the basis for this association.
Shekelle
R B
RB
School of Public Health, University of Texas, Houston 77225.
Rossof
A H
AH
Stamler
J
J
D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology; D002338:Carotenoids / Q000494:pharmacology; D002641:Chicago / Q000453:epidemiology; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D015331:Cohort Studies; D004041:Dietary Fats / Q000494:pharmacology; D004531:Eggs; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012306:Risk; D012907:Smoking; D019207:beta Carotene
D002791:Cholesterol, Dietary; D004041:Dietary Fats; D019207:beta Carotene; D002338:Carotenoids