title: Vascular insufficiency quantitatively aggravates diabetic neuropathy.
abstract: The effect of lower-limb ischemia on the severity of neuropathy was examined in 48 diabetic patients with peripheral vascular disease. The severity of the vascular disease, as determined by medical history, physical findings, and laboratory data, was scored for each leg. Neuropathy was rated clinically and based on the results of nerve conduction studies of the common peroneal, posterior tibial, and sural nerves. A significant correlation was found between the vascular scores and neurologic variables of the two legs, most strikingly so in electrophysiologic data, with coefficients of .6 to .7. Nondiabetic control patients showed no evidence of neuropathy, regardless of the severity of ischemia, whereas diabetic controls without limb ischemia showed symmetrical neuropathy. These findings support the hypoxic theory in the pathogenesis of diabetic neuropathy.
authors.affiliation: Department of Neurosurgery, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Z
authors.initials: Z
authors.lastname: Ram
authors.forename: M
authors.initials: M
authors.lastname: Sadeh
authors.forename: R
authors.initials: R
authors.lastname: Walden
authors.forename: R
authors.initials: R
authors.lastname: Adar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003929:Diabetic Neuropathies / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007511:Ischemia / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009420:Nervous System / Q000503:physiopathology; D010525:Peripheral Nerves / Q000098:blood supply* / Q000503:physiopathology