title: [The enzyme function of cationic transmembrane transport and its relationship to the homeostatic indices of patients with chronic pyelonephritis].
abstract: The paper examines the relationship between the clinical manifestations of pyelonephritis and the functional activity of enzymes of cation transmembrane erythrocyte transport (Mg(2+)-, N(+)-K(+)-, Ca(2+)-ATPases). An individual analysis ascertained that the patients who showed a low Ca(2+)-ATPase activity had marked signs of inflammation in the body, as evidenced by ESR, seromucoid and fibrinogen concentrations. These patients had more significantly depressed immune defense mechanisms as reflected by the levels of immunoglobulins, T-lymphocytes, complement, the neutrophil phagocytosis, and urinary IgA concentrations). Variations were also found in examining the excretion of a number of metabolites. There was a substantial decrease in urea, creatinine, titrated acid, phosphorus excretions in patients with deficient Ca(2+)-ATPase activity than in those with its high activity. It was concluded that there was a relationship between some clinical manifestations of pyelonephritis and the functional activity of enzymes of cation transmembrane transport. To treat metabolic disorders, membrane-protective agents are recommended to include into combined therapy.
authors.forename: V E
authors.initials: VE
authors.lastname: Tsvetsikh
authors.forename: V I
authors.initials: VI
authors.lastname: Krylov
authors.forename: G Ia
authors.initials: GIa
authors.lastname: Lerner
authors.forename: N I
authors.initials: NI
authors.lastname: Kazeko
authors.forename: A A
authors.initials: AA
authors.lastname: Ovchinnikov
authors.forename: B A
authors.initials: BA
authors.lastname: Berdichevskiĭ
authors.forename: R A
authors.initials: RA
authors.lastname: Sultanbaev
authors.forename: V N
authors.initials: VN
authors.lastname: Lykov
mesh_terms: D000251:Adenosine Triphosphatases / Q000097:blood*; D000293:Adolescent; D000328:Adult; D001692:Biological Transport / Q000502:physiology; D002908:Chronic Disease; D004910:Erythrocyte Membrane / Q000201:enzymology* / Q000276:immunology; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011704:Pyelonephritis / Q000201:enzymology* / Q000276:immunology; D014545:Urinary Calculi / Q000201:enzymology / Q000276:immunology
chemical_list: D000251:Adenosine Triphosphatases
vernacular_title: Funktsional'noe sostoianie fermentov kationnogo transmembrannogo transporta i ikh vzaimosviaz' s nekotorymi pokazateliami gomeostaza u bol'nykh khronicheskim pielonefritom.