Single-dose trospectomycin for chlamydial urethritis in men.
Trospectomycin is an aminocyclitol analog of spectinomycin with significant in vitro activity against Chlamydia trachomatis. A single 1-g intramuscular dose was administered to 10 men with symptomatic, culture-positive chlamydial urethritis. Trospectomycin was well tolerated but failed to eradicate chlamydial infection, as determined by cultures obtained approximately 1 week after treatment.
Keefer
M C
MC
Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642.
Menegus
M A
MA
Nasello
M A
MA
Reid
J A
JA
Long
M
M
Reichman
R C
RC
D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D000198:Spectinomycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014526:Urethritis / Q000188:drug therapy* / Q000382:microbiology
D000890:Anti-Infective Agents; C043267:trospectomycin; D000198:Spectinomycin