title: The antiatherogenic dose response effect of verapamil in an experimental atherosclerosis model in the rabbit.
abstract: The aim of the study was to assess the dose dependence of the antiatherogenic effect of verapamil (Isoptin, Lek Ljubljana, Yugoslavia) in rabbits fed 1% cholesterol diet. Verapamil was administered subcutaneously at doses of 0.25, 1 and 2 mg.kg-1/day at 12-hour intervals for 8 weeks. The results indicate verapamil administered s.c. exerts a preventive anti-atherosclerotic effect only in therapeutic doses (0.25 mg.kg-1). The beneficial effect of low-dose verapamil can also be seen in the spectrum of serum lipids as the drug lowers the levels of total cholesterol and triacylglycerols. Compared with the results obtained from a group receiving diet without Ca-antagonist premedication, high doses do not reduce the extent of atheromatous plaques.
authors.affiliation: Department of Pharmacodynamics and Toxicology, Pharmaceutical Faculty, Bratislava, Czechoslovakia.
authors.forename: Z
authors.initials: Z
authors.lastname: Lazarová
authors.forename: S
authors.initials: S
authors.lastname: Edelsteinová
authors.forename: Z
authors.initials: Z
authors.lastname: Lojda
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology; D001161:Arteriosclerosis / Q000473:pathology*; D001794:Blood Pressure / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000097:blood; D004950:Esterases / Q000097:blood; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D011817:Rabbits; D014280:Triglycerides / Q000097:blood; D014700:Verapamil / Q000494:pharmacology*; D001616:beta-Galactosidase / Q000097:blood
chemical_list: D002791:Cholesterol, Dietary; D014280:Triglycerides; D002784:Cholesterol; D014700:Verapamil; D005954:Glucosephosphate Dehydrogenase; D004950:Esterases; D000135:Acid Phosphatase; D001616:beta-Galactosidase; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases