title: Nanoparticles as drug carriers for vinblastine. Acute toxicity of vinblastine in a free form and associated to polybutylcyanoacrylate nanoparticles.
abstract: The possibility of reducing toxicity of Vinblastine by fixing it in polybutyl-2-cyanoacrylate nanoparticles was studied. A significant reduction of mortality of mice was recorded after a single intraperitoneal (i. p.) injection of nanoparticle-associated Vinblastine. A wide range of doses of Vinblastine (1.04-6.25 mg/kg) were used. There was a considerable decrease of leucopenia caused by Vinblastine-loaded polybutyl-2-cyanoacrylate nanoparticles as compared to that induced by free Vinblastine.
authors.affiliation: Scientific Research Centre for Speciality Polymers, Sofia.
authors.forename: M
authors.initials: M
authors.lastname: Simeonova
authors.forename: M
authors.initials: M
authors.lastname: Ilarionova
authors.forename: T
authors.initials: T
authors.lastname: Ivanova
authors.forename: C
authors.initials: C
authors.lastname: Konstantinov
authors.forename: D
authors.initials: D
authors.lastname: Todorov
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D004337:Drug Carriers; D004659:Enbucrilate; D007274:Injections, Intraperitoneal; D051379:Mice; D008815:Mice, Inbred Strains; D008863:Microspheres; D013056:Spectrophotometry, Ultraviolet; D014747:Vinblastine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D004337:Drug Carriers; D014747:Vinblastine; D004659:Enbucrilate