title: [Calcipenic osteopathy in transfusion hemosiderosis and idiopathic hemochromatosis].
abstract: Bone metabolism studies were performed on 5 patients with transfusion haemosiderosis (2 male, 3 female; mean age: 30.8 years) and 5 patients with idiopathic haemochromatosis (2 male, 3 female; mean age: 48.8 years). In the majority of the patients, the modern osteodensitometric method showed a significant decrease of the mineral content of the trabecular and cortical bones. Low calcitonin and dehydroepiandrosterone-sulphate concentrations were measured in the majority of the patients with calcipenic osteopathy. Besides marked bone loss, hypogonadotropic hypogonadism was found in 3 male patients, while normal LH, FSH concentration values were measured in 3 female patients. The prolactin concentration was normal in all 6 patients. The authors suppose that besides the already known pathogenetic factors, insufficient calcitonin effect and especially the partial lack of dehydroepiandrosterone-sulphate can play a role in the development of bone loss connected with iron overload. Further study with a greater number of patients in required to support the above findings.
authors.affiliation: Országos Haematológiai és Vértranszfúziós Intézet, Budapest.
authors.forename: E
authors.initials: E
authors.lastname: Czink
authors.forename: C
authors.initials: C
authors.lastname: Horváth
authors.forename: A A
authors.initials: AA
authors.lastname: Malek
authors.forename: G
authors.initials: G
authors.lastname: Siklósi
mesh_terms: D000328:Adult; D001851:Bone Diseases, Metabolic / Q000209:etiology* / Q000378:metabolism; D002116:Calcitonin / Q000172:deficiency; D002118:Calcium / Q000172:deficiency*; D003687:Dehydroepiandrosterone / Q000172:deficiency; D005260:Female; D006432:Hemochromatosis / Q000150:complications / Q000209:etiology*; D006486:Hemosiderosis / Q000150:complications / Q000209:etiology*; D006801:Humans; D008297:Male; D065227:Transfusion Reaction
chemical_list: D003687:Dehydroepiandrosterone; D002116:Calcitonin; D002118:Calcium
vernacular_title: Calcipeniás osteopathia transzfúziós haemosiderosisban és idiopátiás haemochromatosisban.