title: A Y-chromosomal DNA fragment is conserved in human and chimpanzee.
abstract: A human male-specific Y-chromosomal DNA fragment (lambda YH2D6) has been isolated. By deletion-mapping analysis, 2D6 has been localized to the euchromatic portion of the long arm (Yq11) of the human Y chromosome. Among great apes, this fragment was found to be conserved in male chimpanzee but was lacking in male gorilla and male orangutan. No homologous fragments were detected in females of orangutan, gorilla, chimpanzee, or human. Nucleotide sequence analysis indicated the presence of partial-Alu-elements and of sequences similar to the GATA repeats of the snake Bkm sequence.
authors.affiliation: Department of Structural and Cellular Biology, University of South Alabama, Mobile 36688.
authors.forename: B K
authors.initials: BK
authors.lastname: Rasheed
authors.forename: E C
authors.initials: EC
authors.lastname: Whisenant
authors.forename: R
authors.initials: R
authors.lastname: Fernandez
authors.forename: H
authors.initials: H
authors.lastname: Ostrer
authors.forename: Y M
authors.initials: YM
authors.lastname: Bhatnagar
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D006071:Gorilla gorilla / Q000235:genetics; D006801:Humans; D006922:Hylobates / Q000235:genetics; D008253:Macaca mulatta / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D014998:Y Chromosome