Cloning and functional expression of a TEA-sensitive A-type potassium channel from rat brain.
A rat brain cDNA (Raw3) related to the Drosophila Shaw K+ channel family has been characterized. Raw3 cRNA leads to the formation of TEA-insensitive, fast inactivating (A-type) K+ channels when injected into Xenopus laevis oocytes. Raw3 channels have markedly different properties from the previously cloned rat A-type K+ channel RCK4, Raw3 channels operate in the positive voltage range.
Schröter
K H
KH
Max-Planck-Institut für medizinische Forschung, Heidelberg, Germany.
Ruppersberg
J P
JP
Wunder
F
F
Rettig
J
J
Stocker
M
M
Pongs
O
O
D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004553:Electric Conductivity; D008562:Membrane Glycoproteins / Q000235:genetics; D008969:Molecular Sequence Data; D009865:Oocytes; D015221:Potassium Channels / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D051381:Rats; D011994:Recombinant Proteins / Q000502:physiology; D014982:Xenopus laevis
D008562:Membrane Glycoproteins; D015221:Potassium Channels; D011994:Recombinant Proteins; D004247:DNA