Allergic contact dermatitis from 1,6-diisocyanatohexane in an anti-pill finish.
We report an outbreak of occupational allergic contact dermatitis from 1,6-diisocyanatohexane (old name hexamethylene diisocyanate or HDI), in the anti-pill finish Evafanol AS-1, in 2 clothing factories. The 19 operatives from 2 dressmaking mills all complained of work-related dermatitis. 5 of the subjects had positive patch tests to the fabric with which they were working, and when all 19 were patch tested to Evafanol AS-1 (1% aq.), 11 were positive. 6 of these 11 were patch tested to HDI (1% pet.) and all 6 were positive. It appears that HDI in our group of clothing workers acted as a potent sensitizer affecting around 10% of the workforce.
Wilkinson
S M
SM
Department of Dermatology, North Staffs Hospital Centre, Stoke-on-Trent, UK.
Cartwright
P H
PH
Armitage
J
J
English
J S
JS
D003485:Cyanates / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D005148:Facial Dermatoses / Q000139:chemically induced; D005260:Female; D006229:Hand Dermatoses / Q000139:chemically induced; D006801:Humans; D017953:Isocyanates; D008297:Male; D013784:Textiles
D003485:Cyanates; D017953:Isocyanates; C015262:1,6-hexamethylene diisocyanate