About the presence of a circulating anti-alkaline phosphatase antibody in a trisomy 21 patient's serum.
An electrophoretically slow-moving alkaline phosphatase was found in the serum of a 17-year-old patient with Down's syndrome. Immunological and biochemical studies suggested that this abnormal enzyme pattern consisted of a complex of liver/bone isoenzyme with kappa-type immunoglobulins A and G.
Brissson-Lougarre
A
A
Laboratoire d'Immunopathologie rénale, INSERM CJF 88 01, Faculté de Médecine, Toulouse-Rangueil, France.
Vergnes
H
H
Grozdea
J
J
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000737:chemistry*; D004314:Down Syndrome / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D007070:Immunoglobulin A / Q000737:chemistry; D007074:Immunoglobulin G / Q000737:chemistry; D007145:Immunoglobulin kappa-Chains / Q000737:chemistry; D007527:Isoenzymes; D046911:Macromolecular Substances; D008297:Male
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007527:Isoenzymes; D046911:Macromolecular Substances; D000469:Alkaline Phosphatase