Malignant peripheral nerve sheath tumor arising in a "de novo" ganglioneuroma. A case report.
A case of a "de novo" ganglioneuroma showing an internal area of malignant nerve sheath tumor is described. The tumor arose in an 18-year-old girl without a history of von Recklinghausen's disease. Immunohistochemically, the ganglioneuromatous component was positive with anti-synaptophysin, anti-S100 protein and anti-vimentin antisera, whereas the malignant part was immunoreactive only with anti-S100 protein and anti-vimentin antisera. The patient is free of disease 4 years after surgery. The clinicopathologic features of this rare case are discussed.
Damiani
S
S
Institute of Anatomic Pathology, University of Bologna, Italy.
Manetto
V
V
Carrillo
G
G
Di Blasi
A
A
Nappi
O
O
Eusebi
V
V
D000293:Adolescent; D002471:Cell Transformation, Neoplastic; D005260:Female; D005729:Ganglioneuroma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D009380:Neoplasms, Nerve Tissue / Q000378:metabolism / Q000473:pathology*; D009442:Neurilemmoma / Q000378:metabolism / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000378:metabolism / Q000473:pathology*