Effect of di(2-ethylhexyl)phthalate on 17 beta-hydroxysteroid dehydrogenase activity in testis of rat.
The purpose of the present study was to demonstrate the effects of di(2-ethylhexyl)phthalate (DEHP) on 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activity in the testis of adult rat. DEHP was administered to rats by gavage at doses of 250, 500, 1000 and 2000 mg/kg body wt./d for 15 days. The absolute and relative weights of testes were significantly decreased only at the highest dose level. The activity of 17 beta-HSD was decreased in animals exposed to 1000 and 2000 mg/kg of DEHP. The data suggest that DEHP may affect testicular steroidogenesis adversely.
Srivastava
S
S
Industrial Toxicology Research Centre, Luchnow, India.
Srivastava
S P
SP
D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000284:Administration, Oral; D000818:Animals; D004051:Diethylhexyl Phthalate / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects* / Q000201:enzymology
D004051:Diethylhexyl Phthalate; D015067:17-Hydroxysteroid Dehydrogenases