title: [Levels of blood pepsinogen I in the offspring of patients with duodenal ulcer].
abstract: Hyperpepsinogenemia I is a reliable subclinical marker of the genetical predisposition to suffer duodenal ulcer. For that reason we determine basal serum pepsinogen I (PG I) levels in 25 ulcerous patients and 75% of their offspring and to a control group matched by age and sex. PG I levels in patients and their offspring were significantly higher than those in controls and their offspring (p < 0.001). By establishing an upper normal value of PG I, we identified a subpopulation of normopepsinogenemic ulcerous patients and another with high values (9 normo PG I: 64.3 +/- 6.2 ng/ml vs 16 ulcerous patients with PG I levels: 142.1 +/- 19 ng/ml) (p < 0.001). Of 16 hyperpepsinogenemic patients, 11 offspring (27%) had increased values, what did not happen to any of the offspring of ulcerous patients with normal PG I or control group finding that 80% of male patients with high PG I gave birth to 1 or 2 children with increased values, suggesting a transmission thorough the male character. So gentic role plays an important place in our ulcerous patients but environmental factors appear to decisively influence on the establishment of the disease.
authors.affiliation: Departamento de Medicina, Universidad de Carabobo.
authors.forename: J
authors.initials: J
authors.lastname: Kolster
authors.forename: C
authors.initials: C
authors.lastname: Castro de Kolster
authors.forename: J
authors.initials: J
authors.lastname: Castro
authors.forename: A
authors.initials: A
authors.lastname: Carvajal
authors.forename: C
authors.initials: C
authors.lastname: Callegari
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004381:Duodenal Ulcer / Q000097:blood* / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood*; D014687:Venezuela / Q000453:epidemiology
chemical_list: D005819:Genetic Markers; D010435:Pepsinogens
vernacular_title: Niveles de pepsinógeno i sérico en descendientes de ulcerosos duodenales.