Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments.
Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis.
Peters
P J
PJ
Laboratory of Cell Biology, Medical School, University of Utrecht, The Netherlands.
Neefjes
J J
JJ
Oorschot
V
V
Ploegh
H L
HL
Geuze
H J
HJ
D015703:Antigens, CD; D001402:B-Lymphocytes / Q000378:metabolism*; D001692:Biological Transport; D002461:Cell Line, Transformed; D004705:Endocytosis / Q000276:immunology; D006056:Golgi Apparatus / Q000378:metabolism; D006681:HLA-D Antigens / Q000096:biosynthesis / Q000378:metabolism*; D004854:Herpesvirus 4, Human; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D051907:Lysosomal Membrane Proteins; D008247:Lysosomes / Q000737:chemistry / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000032:analysis; D008565:Membrane Proteins / Q000032:analysis; D015388:Organelles / Q000737:chemistry; D010980:Platelet Membrane Glycoproteins; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface / Q000032:analysis; D060149:Tetraspanin 30; D001619:beta-N-Acetylhexosaminidases / Q000032:analysis
D015703:Antigens, CD; C554586:CD63 protein, human; D006681:HLA-D Antigens; D015395:Histocompatibility Antigens Class I; D051907:Lysosomal Membrane Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D010980:Platelet Membrane Glycoproteins; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface; D060149:Tetraspanin 30; D001619:beta-N-Acetylhexosaminidases