[Transmission of nephrotic syndrome to two neonates. Spontaneous regression].
We report a transient neonatal nephrotic syndrome in two infants born to a mother with idiopathic nephrotic syndromes (INS). The mother, born in Mali in 1966, had a normal first pregnancy, with a normal live child. Six months later a nephrotic syndrome appeared with normal renal function; renal biopsy disclosed slight lesions of focal and segmental glomerulosclerosis. Prednisone and ciclosporin were totally ineffective. In 1986 and 1988 two pregnancies occurred with normal gestation outcome; however, the two births were premature (35 weeks) with hypotrophic infantas (2.160 and 2.080 kg). In both cases urine analysis revealed neonatal heavy proteinuria, with low serum protein and hypoalbuminemia; proteinuria decreased and disappeared within 2 and 3 weeks respectively; simultaneously protidemia and albuminemia were normalized. Thus, a transitory nephrotic syndrome, resolving spontaneously, occurred in two successive offsprings of a patient with INS. These cases are in keeping with the hypothesis that heavy proteinuria in nephrotic syndrome might be linked to a circulating humoral factor and that INS is a disorder linked to T-lymphocyte function with enhanced production of a lymphokine acting on vascular permeability.
Lagrue
G
G
Service de Néphrologie, Association Claude-Bernard, INSERM U 139, Hôpital Henri-Mondor, Créteil.
Branellec
A
A
Niaudet
P
P
Heslan
J M
JM
Guillot
F
F
Lang
P
P
D001798:Blood Proteins / Q000032:analysis; D003404:Creatinine / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D009404:Nephrotic Syndrome / Q000151:congenital*; D011507:Proteinuria; D012075:Remission, Spontaneous
D001798:Blood Proteins; D003404:Creatinine
Transmission d'un syndrome néphrotique à deux nouveau-nés. Régression spontanée.