Inhibition of the growth of cultured human meningioma cells by recombinant interferon-alpha.
In this paper the results of investigations on the effect of interferon-alpha (IFN-alpha) on the growth of meningioma cells in culture is reported. A consecutive series of six meningiomas and one meningioma/neurofibroma derived from a patient with neurofibromatosis type 2 was investigated and it was found that the growth of all seven tumours in response to mitotic stimuli (fetal bovine serum or epidermal growth factor) is strongly inhibited by IFN-alpha. Maximal response varied between 100% and 70% inhibition of the incorporation of tritiated thymidine. In some cases an inhibitory response was obtained already at very low doses (less than or equal to 10 U of IFN-alpha per ml). These results indicate that further clinical investigation of the application of IFN-alpha to the treatment of meningioma is warranted.
Koper
J W
JW
Zwarthoff
E C
EC
Hagemeijer
A
A
Braakman
R
R
Avezaat
C J
CJ
Bergström
M
M
Lamberts
S W
SW
D000328:Adult; D000368:Aged; D001790:Blood Physiological Phenomena; D002455:Cell Division / Q000187:drug effects; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy* / Q000235:genetics; D008579:Meningioma / Q000188:drug therapy* / Q000235:genetics; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000188:drug therapy / Q000235:genetics; D011994:Recombinant Proteins; D014407:Tumor Cells, Cultured
D007370:Interferon Type I; D011994:Recombinant Proteins; D004815:Epidermal Growth Factor