Antibodies to toluene diisocyanate in patients with and without dialysis anaphylaxis.
In a majority of patients with anaphylaxis to dialysis, ethylene oxide has been identified as an etiologic agent. In a significant minority of patients sustaining such reactions, the antigen remains unidentified. Conflicting results have been published with regard to isocyanates as a possible antigen. The authors studied 19 hemodialysis patients with anaphylaxis in whom IgE against ethylene oxide-human serum albumin (ETO-HSA) was not identified (Group 1) and 25 peritoneal dialysis patients without anaphylaxis (Group 2). IgE against toluene diisocyanate-human serum albumin (TDI-HSA) was found in one patient in Group 1, and a similar incidence of IgG against TDI-HSA in Group 1 (16%) and Group 2 (12%) was noted. The results do not suggest that IgE against TDI-HSA is an important cause of dialysis anaphylaxis.
Grammer
L C
LC
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.
Harris
K E
KE
Shaughnessy
M A
MA
Dolovich
J
J
Patterson
R
R
Evans
S
S
D000707:Anaphylaxis / Q000209:etiology / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D010530:Peritoneal Dialysis; D006435:Renal Dialysis / Q000009:adverse effects*; D014051:Toluene 2,4-Diisocyanate / Q000276:immunology*
D007074:Immunoglobulin G; D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E