Effects on isolated arteries from rat, rabbit and man of NNC 70-0270, a synthetic atrial natriuretic factor analogue with a prolonged action.
A new analogue of ANF (atrial natriuretic factor), NNC 70-0270, was tested in various isolated artery preparations. In the rabbit aorta and renal artery NNC 70-0270 was compared with atriopeptin III and the relative inhibitory potency against noradrenaline-induced contractions (atriopeptin III = 1) was found to be 5 and 9, respectively. Furthermore the duration of the effect (after washout) was prolonged. In the rat aorta the relative potency was 0.5 and a prolonged effect was also found in this preparation. In the human pulmonary artery alpha-hANF was used as a reference, and contractions were induced with noradrenaline (seven experiments) or potassium chloride (three experiments). The relative (alpha-hANF = 1) inhibitory potencies were 0.8 and 1.3, respectively. A pronounced prolongation of the effect was also found in this preparation.
Weis
J
J
Department of Pharmacology, Novo Nordisk A/S, Maaloev, Denmark.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001158:Arteries / Q000187:drug effects*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010446:Peptide Fragments / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012077:Renal Artery / Q000187:drug effects
D003692:Delayed-Action Preparations; C074350:NNC 70-0270; D010446:Peptide Fragments; C472610:atrial natriuretic peptide, rat; C062525:atrial natriuretic factor prohormone (103-126); D009320:Atrial Natriuretic Factor