title: Control of self-reactivity in the intestine.
abstract: In the intestine maintenance of self-tolerance may involve tissue-specific self-Ags, APCs, 'second signals', and extrathymic pathways of T cell maturation. These factors combine to create a unique environment where autoimmune tissue destruction is prevented despite local inflammatory influences. In this review we summarize our findings using a TCR-gamma delta transgenic model where self-tolerance was maintained by clonal deletion for cells localizing to peripheral lymphoid tissue and by clonal anergy for cells localizing to the intraepithelial compartments. Several possible explanations exist for these results but in general, these findings have implications for the maintenance of self-tolerance of normal TCR-alpha beta and TCR-gamma delta IELs in epithelial tissues such as the intestine.
authors.affiliation: University of Chicago, Department of Medicine, Ill.
authors.forename: T A
authors.initials: TA
authors.lastname: Barrett
authors.forename: S M
authors.initials: SM
authors.lastname: Hedrick
authors.forename: A L
authors.initials: AL
authors.lastname: Dent
authors.forename: M L
authors.initials: ML
authors.lastname: Delvy
authors.forename: D M
authors.initials: DM
authors.lastname: Kennedy
authors.forename: L A
authors.initials: LA
authors.lastname: Matis
authors.forename: J A
authors.initials: JA
authors.lastname: Bluestone
mesh_terms: D000818:Animals; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D007108:Immune Tolerance; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta