title: [Acute megakaryoblastic leukemia. Relation to trisomy 21].
abstract: Two cases of acute megakaryoblastic leukemia in a 4 month-old and a 13 year-old girl are described. In the first case who presented with a large hepatomegaly and portal fibrosis, the diagnosis was made from the surface phenotyping of megakaryoblasts; a trisomy 13, 14 and 19 and an extra chromosome X were present in the bone marrow. An electron microscopy study of megakaryoblasts was necessary to identify the second case. Both children died shortly after treatment (cytosine-arabinoside at low dosage in the first case and polychemotherapy in the second). The 51 other cases reported in the literature are reviewed.
authors.affiliation: Service de Pédiatrie, CHRU et du Laboratoire d'Anatomo-Pathologie, Caen.
authors.forename: X
authors.initials: X
authors.lastname: Levaltier
authors.forename: O
authors.initials: O
authors.lastname: Reman
authors.forename: P
authors.initials: P
authors.lastname: Boutard
authors.forename: J C
authors.initials: JC
authors.lastname: Mandard
authors.forename: X
authors.initials: X
authors.lastname: Troussard
authors.forename: M
authors.initials: M
authors.lastname: Leporrier
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D004314:Down Syndrome / Q000150:complications / Q000235:genetics*; D005260:Female; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000150:complications / Q000235:genetics* / Q000628:therapy
vernacular_title: Leucémie aiguë mégacaryoblastique. Relation avec la trisomie 21.