Abnormal desolvation behavior on solvate of etodolac sodium salt.
Sodium salts of (+/-)- and (+)-etodolac were prepared and characterized: the (+/-)-sodium salt contained 5.26% water and 1.09% acetonitrile, and the (+)-sodium salt contained 1.14% water and 2.02% other volatiles (methanol and acetonitrile). Abnormal hygroscopic behavior of the (+/-)-etodolac sodium salt was observed; that is, it lost weight (5.4%) at 75% RH for 7 days. A possible reason for the abnormal hygroscopic behavior is nucleation phenomenon at the interface; that is, a surface change may occur in the presence of water vapor with nucleation by small crystals of the product.
Zawadzki
J
J
Pharmacy Research and Development, Wyeth-Ayerst Research, Rouses Point, NY 12979.
Lee
H K
HK
DeNeale
R
R
Enever
R
R
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000493:pharmacokinetics; D001682:Biological Availability; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D017308:Etodolac; D006813:Humidity; D007210:Indoleacetic Acids / Q000737:chemistry* / Q000493:pharmacokinetics; D008970:Molecular Weight; D012995:Solubility; D013696:Temperature; D014867:Water / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007210:Indoleacetic Acids; D014867:Water; D017308:Etodolac