Sequences of four previously undescribed human T-cell receptor beta chain variable genes.
T-cell receptor beta chain mRNA from 4 human T-lymphocyte clones was reverse transcribed, amplified by PCR, cloned in M13 and sequenced. Four hitherto undescribed variable genes were found. One of them (V beta-IW22) showed the highest homology (74.5%) to V beta 1. Two others (V beta-IW6 and V beta-IW10) belonged to the recently described V beta 21 family. The last gene (V beta-VW114) belonged to the V beta 9 family. However, the latter gene a is pseudogene because of an in-frame stop codon.
Hansen
T
T
Institute of Transplantation Immunology, National Hospital, Oslo, Norway.
Qvigstad
E
E
Lundin
K E
KE
Thorsby
E
E
D000595:Amino Acid Sequence; D001483:Base Sequence; D002999:Clone Cells; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D013601:T-Lymphocytes
D016693:Receptors, Antigen, T-Cell, alpha-beta