[Cadmium-induced changes in the activity of the dopaminergic and purinergic systems and in ascorbic acid catabolism in the rat striatum].
Levels of dopamine (DA), 3-4-dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA), dehydroascorbic acid (DHAA), uric acid (UA) and adenosine (ADO), were determined by HPLC in the striatum of male Wistar rats treated with repeated injections of cadmium (as sulfate) 3 mg/kg/day s.c. for 10 consecutive days. Cadmium treatment significantly reduced DOPAC levels with consequent decrease of the DOPAC/DA ratio; AA levels were significantly reduced, while DHAA levels were significantly increased, with consequent increase of DHAA/AA ratio: levels of UA and ADO were both significantly increased. It is concluded that cadmium, given systemically, reduces dopaminergic system activity in the rat striatum; such impairment occurs together with an increase of AA oxidation and of markers of purinergic system activity. The inhibition of striatal dopaminergic activity could be considered the neurochemical basis of behavioral changes induced by cadmium, while the increase of AA oxidation and of purinergic system activity could be considered an antitoxic metabolic response.
Desole
M S
MS
Istituto di Farmacologia, Università degli Studi di Sassari.
Miele
M
M
Esposito
G
G
Fresu
L
L
Enrico
P
P
De Natale
G
G
Anania
V
V
Miele
E
E
D000241:Adenosine / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D002104:Cadmium / Q000633:toxicity*; D019187:Cadmium Compounds; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D011983:Receptors, Purinergic / Q000187:drug effects* / Q000378:metabolism; D013431:Sulfates; D014527:Uric Acid / Q000378:metabolism
D019187:Cadmium Compounds; D011954:Receptors, Dopamine; D011983:Receptors, Purinergic; D013431:Sulfates; D002104:Cadmium; D014527:Uric Acid; C037123:cadmium sulfate; D000241:Adenosine; D001205:Ascorbic Acid; D004298:Dopamine
Modificazioni da cadmio dell'attività dei sistemi dopaminergico e purinergico e del catabolismo dell'acido ascorbico nello striato del ratto.