Deuterium oxide, dimethylsulfoxide and heat shock confer protection against hydrostatic pressure damage in yeast.
Deuterium oxide, dimethylsulfoxide (Me2SO) and heat shock treatment were all significantly effective at baro-injury as measured by plating efficiency after decompression. The content of unfreezable cell water was observed to increase during heat treatment, and this increase was associated with increase in viability.
Komatsu
Y
Y
Fermentation Research Institute, Ibaraki, Japan.
Obuchi
K
K
Iwahashi
H
H
Kaul
S C
SC
Ishimura
M
M
Fahy
G M
GM
Rall
W F
WF
D003903:Deuterium / Q000494:pharmacology*; D017666:Deuterium Oxide; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D005615:Freezing; D006360:Heat-Shock Proteins / Q000096:biosynthesis* / Q000302:isolation & purification; D006358:Hot Temperature; D006874:Hydrostatic Pressure; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000502:physiology*; D014867:Water / Q000494:pharmacology*
D006360:Heat-Shock Proteins; D014867:Water; D003903:Deuterium; D017666:Deuterium Oxide; D004121:Dimethyl Sulfoxide