Elimination of benfluron and its metabolites in the faeces and urine of rats.
The study of the biotransformation of the potential cytostatic benfluron has been continued. The elimination of benfluron and of nine of its metabolites whose structure had been established, mainly on the basis of the comparison of their IR, MS and NMR spectra with those of standards, was studied. After oral administration of 500 mg.kg-1 to rats, the amounts of these substances in the faeces and urine were followed up by high-performance liquid chromatography for five days. Striking qualitative and quantitative differences were observed in the elimination of benfluron and its metabolites by both routes.
Nobilis
M
M
Institute of Experimental Biopharmaceutics, Czechoslovak Academy of Sciences, Hradec Králové.
Kvasnicková
E
E
Sroler
A
A
Hais
I M
IM
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000652:urine; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000737:chemistry*; D005449:Fluorenes / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000970:Antineoplastic Agents; D005449:Fluorenes; C041513:benzo(c)fluorene; C034234:VUFB 13468