Ki-67 staining in histological subtypes of breast carcinoma and fine needle aspiration smears.
Thirty four cases of invasive breast carcinoma were analysed for heterogeneity of Ki-67 reactivity in a tumour, and proliferative activity in various histological subtypes was compared. The growth factions determined in areas of central and peripheral tumour were the same. Mucinous and lobular carcinoma showed lower Ki-67 activity than ductal carcinomas. When ductal carcinomas were subdivided according to their dominant growth pattern, the carcinomas with a solid or comedo growth pattern showed the highest proliferative activity. These results largely confirm data from previous cell kinetic studies on the incorporation of radioactively labelled thymidine. A correlation between the growth fraction determined by Ki-67 in fine needle aspiration smears and cryostat sections of corresponding tumours was shown, implying that the immunostaining of cytological smears gives a reliable impression of the growth fraction of a tumour and may therefore be used in prospective studies.
Kuenen-Boumeester
V
V
Department of Pathology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
Van Der Kwast
T H
TH
Van Laarhoven
H A
HA
Henzen-Logmans
S C
SC
D002288:Adenocarcinoma, Mucinous / Q000276:immunology; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000276:immunology; D002455:Cell Division; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen; D009687:Nuclear Proteins / Q000032:analysis* / Q000276:immunology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D019394:Ki-67 Antigen; D009687:Nuclear Proteins