[Inhibitory effect of aclarubicin, an anthracycline antibiotic, on the activity of suppressor cells in mice].
Antisuppressant activity of aclarubicin, an anthracycline antibiotic, was studied on models of immunodepression induced in vivo by concanavalin A or associated with progressive tumor growth. In vivo in a dose of 2.5 mg/kg aclarubicin markedly lowered or completely eliminated the ability of concanavalin A to induce activity on the suppressor cells in the mouse spleen. In vitro in doses of 0.0001 to 0.01 micrograms/ml aclarubicin decreased the suppressing activity of the splenocytes from mice with solid tumors in regard to spontaneous proliferation of the lymphoid cells.
Viadro
M M
MM
D015250:Aclarubicin / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003208:Concanavalin A / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*
D003208:Concanavalin A; D015250:Aclarubicin
Ingibiruiushchiĭ éffekt aklarubitsina na aktivnost' suppressornykh kletok u mysheĭ.