Development of delta opioid peptides as nonaddicting analgesics.
Although much effort has been devoted to opioid research since the identification of enkephalins, understanding of the physiological importance and mechanisms of action of endogenous opioids lags behind understanding of opiate alkaloids such as morphine. In recent years, several novel approaches have been refined with promise for the successful development of the long-awaited nonaddicting analgesics that act at the opioid delta receptor. The present communication reviews these efforts.
Rapaka
R S
RS
Division of Preclinical Research, National Institute on Drug Abuse, Rockville, Maryland 20857.
Porreca
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F
D000700:Analgesics / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D008297:Male; D009294:Narcotics / Q000138:chemical synthesis* / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects*; D017465:Receptors, Opioid, delta
D000700:Analgesics; D009294:Narcotics; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta