[Studies on antinephritic effects of plant components in rats (2): Effects of ginsenosides on original-type anti-GBM nephritis in rats and its mechanisms].
To clarify the antinephritic effects of ginsenosides, we investigated the effects of crude ginsenoside and ginsenosides Rg1 and Rb1 on original-type anti-GBM nephritis in rats. Crude ginsenoside at 1.0 mg and 5.0 mg/kg, i.p., and ginsenoside Rg1 at 1.0 mg/kg, i.p., prevented urinary protein excretion and elevation of serum cholesterol content, as well as histopathological changes such as hypercellularity and adhesion. On the other hand, ginsenoside Rb1 only inhibited the histopathological parameters. In order to clarify the antinephritic mechanisms of ginsenosides on this model, we investigated the effect of ginsenosides on platelet aggregation and renal blood flow. Crude ginsenoside markedly enhanced the renal blood flow. Ginsenoside Rg1 inhibited the platelet aggregation in vivo and enhanced the renal blood flow on the 1st day. These results suggest that crude ginsenoside and Rg1 exert their antinephritic action via increased renal blood flow.
Hattori
T
T
Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Ito
M
M
Suzuki
Y
Y
D000818:Animals; D036145:Ginsenosides; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010975:Platelet Aggregation Inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000187:drug effects; D012503:Saponins / Q000494:pharmacology / Q000627:therapeutic use*; D013047:Specific Pathogen-Free Organisms
D036145:Ginsenosides; D010975:Platelet Aggregation Inhibitors; D012503:Saponins