title: [The efficacy of preventive chemotherapy in inhabitants of rural areas at increased risk of tuberculosis].
abstract: Observation of 3976 patients living in the villages to be registered at the Central District Hospital as a group of higher risk of tuberculosis was conducted. An active process in these patients was discovered in 0.67 per cent of the cases, being 11 times higher than among the whole rural population of the district. The rate of an active process depends on the nature of disease causing the patients' registration under a risk group as well as on their response to the Mantoux test with 2 TU. Administration of preventive chemotherapy can promote a 2.5-fold decrease in the number of tuberculosis cases among those having a hyperergic response to tuberculin.
authors.forename: L M
authors.initials: LM
authors.lastname: Litvin
authors.forename: N N
authors.initials: NN
authors.lastname: Romanchenko
authors.forename: R S
authors.initials: RS
authors.lastname: Koltoniuk
mesh_terms: D006801:Humans; D007538:Isoniazid / Q000031:analogs & derivatives / Q000627:therapeutic use*; D012307:Risk Factors; D012423:Rural Health; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D014455:Ukraine / Q000453:epidemiology
chemical_list: D007538:Isoniazid
vernacular_title: Effektivnost' khimioprofilaktiki u zhiteleĭ sel'skoĭ mestnosti s povyshennym riskom zabolevaniia tuberkulezom.