Pharmacology of long-term potentiation. A model for learning reviewed.
Long-term potentiation is widely used as a model for memory formation. Recently, much information concerning this topic like the involvement of protein kinase C, arachidonic acid and N-methyl-D-aspartate receptors has been reported. In this review recent discoveries concerning long-term potentiation and the pharmacological implications for the development of cognition-enhancing drugs are discussed.
Beukers
M
M
Division of Medicinal Chemistry, Gorlaeus Laboratories, Leiden, The Netherlands.
Boddeke
E W
EW
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D006801:Humans; D008568:Memory / Q000502:physiology*; D008960:Models, Psychological; D011493:Protein Kinase C / Q000378:metabolism / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000378:metabolism / Q000502:physiology; D011950:Receptors, Cholinergic / Q000378:metabolism / Q000502:physiology; D015290:Second Messenger Systems; D013569:Synapses / Q000378:metabolism*
D001095:Arachidonic Acids; D005971:Glutamates; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic; D016718:Arachidonic Acid; D011493:Protein Kinase C; D002118:Calcium