Genetic analysis of homology between the virulence plasmids of Salmonella dublin and Yersinia pseudotuberculosis.
Two segments within the virulence region of Salmonella dublin plasmid pSDL2 that were homologous to regions on Yersinia pseudotuberculosis plasmid pIB1 were located with regard to the four known genes (vsdA, vsdB, vsdC, and vsdD) of pSDL2. One segment mapped upstream of vsdA within an insertion element related to IS630 of Shigella sonnei; the second was confined to a 45-bp sequence containing an inverted repeat between vsdC and vsdD. On pIB1, both areas were located in an intergenic region upstream of yopH. These results indicate that the homology between Yersinia and Salmonella virulence plasmids is not located within structural genes.
Krause
M
M
Department of Medicine, University of California, San Diego 92103.
Harwood
J
J
Fierer
J
J
Guiney
D
D
D000595:Amino Acid Sequence; D001483:Base Sequence; D008969:Molecular Sequence Data; D010957:Plasmids; D012475:Salmonella / Q000235:genetics* / Q000472:pathogenicity; D012689:Sequence Homology, Nucleic Acid; D014774:Virulence; D015011:Yersinia pseudotuberculosis / Q000235:genetics* / Q000472:pathogenicity