Evidence for a role of phosphofructokinase and tRNA in the polyribosome disaggregation of amino acid deficiency.
The activity of rabbit muscle phosphofructokinase was inhibited by transfer ribonucleic acid. This inhibition was reduced by inclusion of an amino-acyl-tRNA charging system. The results are discussed in terms of the loss of ATP in amino acid deprived cells and in the critical role of fructose 1,6-diphosphate in peptide chain initiation.
Rabinovitz
M
M
Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda, MD.
D000596:Amino Acids / Q000378:metabolism* / Q000494:pharmacology; D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism; D000818:Animals; D007700:Kinetics; D009132:Muscles / Q000201:enzymology; D010732:Phosphofructokinase-1 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011132:Polyribosomes / Q000378:metabolism* / Q000648:ultrastructure; D012343:RNA, Transfer / Q000378:metabolism* / Q000494:pharmacology; D011817:Rabbits
D000596:Amino Acids; D012343:RNA, Transfer; D010732:Phosphofructokinase-1; D000604:Amino Acyl-tRNA Synthetases