title: Acquisition of iron from host sources by mesophilic Aeromonas species.
abstract: The mesophilic Aeromonas species are opportunistic pathogens that produce either of the siderophores amonabactin or enterobactin. Acquisition of iron for growth from Fe-transferrin in serum was dependent on the siderophore amonabactin; 50 of 54 amonabactin-producing isolates grew in heat-inactivated serum, whereas none of 30 enterobactin-producing strains were able to grow. Most isolates (regardless of siderophore produced) used haem as a sole source of iron for growth; all of 33 isolates grew with either haematin or haemoglobin and 30 of these used haemoglobin when complexed to human haptoglobin. Mutants unable to synthesize a siderophore used iron from haem, suggesting that this capacity was unrelated to siderophore production. Some members of the mesophilic Aeromonas species have evolved both siderophore-dependent and -independent mechanisms for acquisition of iron from a host.
authors.affiliation: Department of Microbiology, University of Mississippi Medical Center, Jackson 39216.
authors.forename: G
authors.initials: G
authors.lastname: Massad
authors.forename: J E
authors.initials: JE
authors.lastname: Arceneaux
authors.forename: B R
authors.initials: BR
authors.lastname: Byers
mesh_terms: D000333:Aeromonas / Q000254:growth & development / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D001769:Blood; D001770:Blood Bactericidal Activity; D003470:Culture Media; D004758:Enterobactin / Q000378:metabolism; D006242:Haptoglobins; D006427:Hemin / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism; D017262:Siderophores; D014168:Transferrin / Q000378:metabolism*
chemical_list: D003470:Culture Media; D006242:Haptoglobins; D006454:Hemoglobins; D007502:Iron Chelating Agents; D009842:Oligopeptides; D017262:Siderophores; D014168:Transferrin; C065805:amonabactin P; C065804:amonabactin T; D004758:Enterobactin; D006427:Hemin; D007501:Iron