[Structural-functional state of the hypertensive heart and atrial natriuretic factor during treatment with nifedipine].
The time course of structural and functional parameters using echocardiography and the level of atrial natriuretic factor (ANF) employing immunoradiometric assay were examined in 37 patients with essential hypertension taking a 3-week therapy with nifedipine (corinfar) in doses individually chosen. The changes in the structural and functional parameters of the hypertensive heart were found to be associated with its endocrine function. A course therapy of patients with essential hypertension with nifedipine in individually based doses caused a significant rise in plasma ANF levels, a normalization of cardiac compensatory mechanism function. The findings may be a basis for studying the new mechanisms of calcium antagonist action.
Bobrov
V A
VA
Shershnev
V G
VG
Polivoda
S N
SN
Konoshevich
S N
SN
D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004452:Echocardiography; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use*
D009320:Atrial Natriuretic Factor; D009543:Nifedipine
Strukturno-funktsional'noe sostoianie gipertenzivnogo serdtsa i predserdnyĭ natriĭureticheskiĭ faktor pri lechenii nifedipinom.