Plasma concentrations of disulfiram after injection of suspended micropellets into alcoholic subjects.
The disposition of disulfiram after administration in a new formulation was studied in rats and alcoholic patients. The suspension consisted of microcrystals suspended in a mixture of propylene glycol and water and injected subcutaneously into rats and humans; the course of the plasma concentration of diethyldithiocarbamate with time was followed by gas-liquid chromatography. Systemic delivery of disulfiram was observed to occur for a month. The data demonstrate that this form has the properties of a sustained-release formulation when implanted subcutaneously. There was no evidence of local or systemic adverse reactions.
Cid
E
E
Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago.
Cid
E
E
Feuerhake
O
O
Boisier
I
I
Chandía
R
R
D000328:Adult; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D003692:Delayed-Action Preparations; D004221:Disulfiram / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004050:Ditiocarb / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003692:Delayed-Action Preparations; D004050:Ditiocarb; D004221:Disulfiram