Bacterial translocation from the gastrointestinal tract in various mouse models for human diabetes.
Bacterial translocation from the gastrointestinal (GI) tract to other internal organs was examined in multiple low-dose streptozotocin-injected (M-STZ), single large-dose streptozotocin-injected (S-STZ), alloxan-injected (Alloxan), and non-obese diabetic (NOD) mice. The incidence of bacterial translocation from the GI tract to the tested organs among diabetic mice was in the order of M-STZ mice greater than S-STZ mice greater than NOD, Alloxan, and control mice. The injections of insulin to M-STZ mice did not decrease the incidence of translocation. These results suggest that bacterial translocation from the GI tract in diabetic mice is not induced by diabetes.
Ohsugi
T
T
Laboratory Animals Breeding Facilities, Osaka University Medical School, Japan.
Maejima
K
K
Urano
T
T
D000818:Animals; D001769:Blood / Q000382:microbiology; D002432:Cecum / Q000382:microbiology; D002465:Cell Movement; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000382:microbiology*; D004064:Digestive System / Q000382:microbiology*; D004927:Escherichia coli Infections / Q000150:complications*; D005766:Gastrointestinal Contents / Q000382:microbiology*; D008099:Liver / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010537:Peritoneum / Q000382:microbiology; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000382:microbiology