Transient anticardiolipin antibodies, functional protein S deficiency, and deep vein thrombosis.
A 30-year-old man presented with an episode of deep vein thrombosis. He was found to have primary antiphospholipid syndrome with anticardiolipin antibodies and protein S deficiency. All other investigations were negative. Three months later, anticardiolipin antibodies were negative and protein S levels were normal. The transient presence of anticardiolipin antibodies and functional protein S deficiency in this patient suggests a new mechanism for the association between anticardiolipin antibodies and venous thrombosis.
Sthoeger
Z M
ZM
Department of Medicine C, Kaplan Hospital, Rehovot, Israel.
Sthoeger
D
D
Mellnick
S D
SD
Steen
D
D
Berrebi
A
A
D000328:Adult; D000906:Antibodies / Q000276:immunology* / Q000378:metabolism / Q000502:physiology; D002308:Cardiolipins / Q000276:immunology*; D006023:Glycoproteins / Q000172:deficiency* / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D017293:Protein S; D013924:Thrombophlebitis / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology
D000906:Antibodies; D002308:Cardiolipins; D006023:Glycoproteins; D017293:Protein S