title: Nocturnal sleep and oxygen balance in Duchenne muscular dystrophy. A clinical and polygraphic 2-year follow-up study.
abstract: A long-term, clinical and polygraphic investigation of nocturnal sleep was performed in nine non-ambulatory Duchenne muscular dystrophy patients (mean age 16.2 years, range 10-20) with normal daytime blood gas tensions. The data show that nocturnal sleep has some adverse influence on oxygen balance in these patients as suggested by the occurrence of arterial oxyhaemoglobin desaturation occurring mainly during REM stages. This adverse effect tended to worsen significantly within a 2-year period in the absence of any sleep-related symptoms. A significant correlation between the degree of oxygen imbalance during sleep and the degree of restrictive thoracic syndrome during wakefulness was shown.
authors.affiliation: Neurologic Clinic, University of Pavia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Manni
authors.forename: C
authors.initials: C
authors.lastname: Zucca
authors.forename: C A
authors.initials: CA
authors.lastname: Galimberti
authors.forename: A
authors.initials: A
authors.lastname: Ottolini
authors.forename: I
authors.initials: I
authors.lastname: Cerveri
authors.forename: C
authors.initials: C
authors.lastname: Bruschi
authors.forename: M C
authors.initials: MC
authors.lastname: Zoia
authors.forename: G
authors.initials: G
authors.lastname: Lanzi
authors.forename: A
authors.initials: A
authors.lastname: Tartara
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003430:Cross-Sectional Studies; D004569:Electroencephalography / Q000295:instrumentation*; D005500:Follow-Up Studies; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis / Q000503:physiopathology*; D008137:Longitudinal Studies; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D009136:Muscular Dystrophies / Q000175:diagnosis / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood*; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000503:physiopathology*; D012894:Sleep Stages / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology
chemical_list: D010100:Oxygen