Primary urinary cytodiagnosis of a bladder small-cell carcinoma.
A small-cell undifferentiated tumor of the bladder in a 69-yr-old man with asymptomatic hematuria is described. Urine cytology showed abundant, small, round-to-oval hyperchromatic cells with coarse chromatin, nuclear molding, and high nuclear/cytoplasmic ratios. A primary cytodiagnosis of small-cell undifferentiated cancer with associated severe urothelial atypia was made. Immunohistochemical stains were negative for neuron-specific enolase, leukocyte common antigen, chromogranin, epithelial membrane antigen, prostatic acid phosphatase, and prostate-specific phosphatase. The diagnosis was confirmed histologically by studies performed on cystoscopic bladder biopsy material.
Rollins
S
S
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City 84132.
Schumann
G B
GB
D000368:Aged; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000473:pathology / Q000652:urine; D002467:Cell Nucleus / Q000473:pathology; D002843:Chromatin / Q000473:pathology; D003581:Cytodiagnosis; D003593:Cytoplasm / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009362:Neoplasm Metastasis; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000652:urine; D014556:Urine / Q000166:cytology*
D002843:Chromatin