Evaluation of praziquantel for treatment of experimentally induced paragonimiasis in dogs and cats.
Praziquantel was used successfully for treatment of a small number of dogs and 1 cat infected with Paragonimus kellicotti. To further evaluate the usefulness of this drug in treating such infections, 7 cats and 7 dogs were inoculated orally with metacercariae (12 and 20 to 22, respectively) obtained from crayfish, then were treated after the infections became patent; 2 cats and 2 dogs served as noninfected controls. Beginning 1 week before infection, and continuing weekly thereafter, physical, hematologic, and fecal examinations were performed on each animal; thoracic radiography was performed every other week. By postinoculation week 6, all dogs given metacercariae had patent infection diagnosed on the basis of positive results of fecal examination. By postinoculation week 7, 5 cats had confirmed patent infection, but 2 cats given metacercariae never had patent infection or had signs of infection. Clinical signs of infection were minor and included increased respiratory tract noise, slight inducible cough, or mild dyspnea. Transient eosinophilia was detected in dogs around postinoculation week 3. Pretreatment radiography revealed cavitated lesions in cats only; pleural lines and patchy infiltrates in cats and dogs; or pneumothorax in dogs only. The treatment regimen consisted of 23 mg of praziquantel/kg of body weight given every 8 hours for 3 days; 1 infected cat and dog were not treated. By 11 days after treatment, eggs had disappeared from the feces of infected animals, and marked resolution of lung lesions was evident radiographically.(ABSTRACT TRUNCATED AT 250 WORDS)
Bowman
D D
DD
Department of Veterinary Microbiology, New York State College of Veterinary Medicine, Cornell University, Ithaca.
Frongillo
M K
MK
Johnson
R C
RC
Beck
K A
KA
Hornbuckle
W E
WE
Blue
J T
JT
D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy* / Q000209:etiology; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D004341:Drug Evaluation; D005243:Feces / Q000469:parasitology; D005260:Female; D008297:Male; D010237:Paragonimiasis / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D010238:Paragonimus; D010270:Parasite Egg Count / Q000662:veterinary; D011223:Praziquantel / Q000627:therapeutic use*; D013047:Specific Pathogen-Free Organisms
D011223:Praziquantel