[Comparison of the frequency of detection of autoantibodies to epidermal antigens with the level of antibodies to polysaccharide of group A Streptococcus and the number of T-suppressors in glomerulonephritis].
By the acute glomerulonephritis (GN) of streptococcal etiology, autoantibodies (AA) reacting with the basal layer of skin epithelium (BLSE) are discovered. The presence of this AA's correlate with the high level of antibodies to the streptococcal group A polysaccharide (A-PS). In the control sera such AA's and the high level antibodies to A-PS are discovered very rarely. By the GN of non-streptococcal etiology, AA's to the BLSE apparently of other specificity are obtained in some cases, in spite of the absence of antibodies to A-PS. AA's reacting with the differentiated layers of skin epithelium are discovered in the high percent of cases by GN. The presence of these AA's do not correlate with the levels of antibodies to A-PS. The reduction of the number of T-lymphocyte suppressors is established in the blood by the presence of AA's to the BLSE by GN. This question is a subject of later investigations by the different autoimmune processes. Such data can apparently corroborate the previously expressed hypothesis, that AA's to BLSE, which as a rule react with endocrine thymus epithelium, are the cause of the beginning of immunoregulatory disorders, characteristic of autoimmune processes.
Evtushenko
E S
ES
Bazanova
E A
EA
Liampert
I M
IM
Borodiiuk
N A
NA
Asoskova
T K
TK
Sitnikova
V P
VP
Goriaĭnova
A N
AN
D000208:Acute Disease; D000293:Adolescent; D000907:Antibodies, Bacterial / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004817:Epidermis / Q000276:immunology*; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013290:Streptococcal Infections / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000907:Antibodies, Bacterial; D001323:Autoantibodies; D011135:Polysaccharides, Bacterial
Sopostavlenie chastoty obnaruzheniia autoantitel k antigenam épidermisa s urovnem antitel k polisakharidu streptokokka gruppy A i chislom T-supressorov pri glomerulonefrite.