title: Heparin and platelet interactions influence alloantigen-induced proliferative responses of human T lymphocytes and immunoglobulin synthesis in vivo.
abstract: In contrast to defibrinated blood, cells isolated from heparinized blood give lower T-lymphoproliferative responses. Such responses can be also suppressed by addition of heparin to lymphocyte cultures. Platelets inhibit T cell proliferation and B cell differentiation, but their interactions with heparin may produce contrasting effects on different immune functions.
authors.affiliation: Department of Immunology, Transplantation Institute, Warsaw Medical School, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Górski
authors.forename: M
authors.initials: M
authors.lastname: Wasik
authors.forename: B
authors.initials: B
authors.lastname: Stepień-Sopniewska
authors.forename: T
authors.initials: T
authors.lastname: Glapiński
mesh_terms: D000917:Antibody Formation; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D007519:Isoantigens / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
chemical_list: D007519:Isoantigens; D006493:Heparin