Phosphatidylinositol membrane anchors and T-cell activation.
A number of lymphocyte proteins are attached to the cell membrane via glycophosphatidylinositol-anchoring domains. Antibodies specific for several of these proteins are potent mitogens for T cells. In this article, Peter Robinson reviews recent evidence for the involvement of these membrane anchors in cell signalling events and discusses their possible significance in providing antigen-independent costimulatory signals to lymphoid cells.
Robinson
P J
PJ
Transplantation Biology Section, Clinical Research Centre, Harrow, Middlesex, UK.
D000818:Animals; D002462:Cell Membrane / Q000276:immunology*; D006017:Glycolipids / Q000502:physiology*; D017261:Glycosylphosphatidylinositols; D008024:Ligands; D008213:Lymphocyte Activation / Q000276:immunology*; D010716:Phosphatidylinositols / Q000502:physiology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D006017:Glycolipids; D017261:Glycosylphosphatidylinositols; D008024:Ligands; D010716:Phosphatidylinositols