The effect of chronic oral methadone treatment on monkey chorionic gonadotropin, estradiol, dehydroepiandrosterone sulfate, progesterone, prolactin and cortisol levels during pregnancy in the cynomolgus monkey (Macaca fascicularis).
The effect of chronic methadone treatment upon the serum levels of Estradiol (E2), Progesterone (P), Prolactin (Prl), monkey chorionic gonadotropin (mCG), dehydroepiandrosterone sulfate (DHEAS) and Cortisol (C) in pregnant Cynomolgus monkeys (Macaca fascicularis) is described in comparison with the hormone levels in a control group. Only DHEAS was significantly decreased in late pregnancy in the methadone group. From these data it can not be concluded that methadone treatment compromises (feto)placental function. The observed intra-uterine growth retardation in the methadone treated group might be a result of a direct influence of methadone upon growth.
Hein
P R
PR
Department of Obstetrics and Gynecology, University Hospital Nijmegen, The Netherlands.
Schatorjé
J S
JS
Frencken
H J
HJ
Segers
M F
MF
Thomas
C M
CM
D000818:Animals; D001724:Birth Weight / Q000187:drug effects*; D006063:Chorionic Gonadotropin / Q000097:blood; D003687:Dehydroepiandrosterone / Q000097:blood*; D004958:Estradiol / Q000097:blood; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006854:Hydrocortisone / Q000097:blood; D008252:Macaca fascicularis; D008691:Methadone / Q000009:adverse effects*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000097:blood
D006063:Chorionic Gonadotropin; D003687:Dehydroepiandrosterone; D011374:Progesterone; D004958:Estradiol; D008691:Methadone; D006854:Hydrocortisone