An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance.
In this report, administration of a recombinant interleukin-1 receptor antagonist protein to mice was found to inhibit induction of colony-stimulating factor as well as induction of early endotoxin tolerance by lipopolysaccharide. These findings provide direct evidence that interleukin-1 is an intermediate in these two lipopolysaccharide-induced phenomena.
Henricson
B E
BE
Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Neta
R
R
Vogel
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SN
D000818:Animals; D004731:Endotoxins / Q000276:immunology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis / Q000097:blood*; D007108:Immune Tolerance / Q000187:drug effects; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000276:immunology*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D011506:Proteins; D011994:Recombinant Proteins; D012795:Sialoglycoproteins
D004731:Endotoxins; C507764:Il1rn protein, mouse; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D008070:Lipopolysaccharides; D011506:Proteins; D011994:Recombinant Proteins; D012795:Sialoglycoproteins; C044101:endotoxin, Escherichia coli; D016178:Granulocyte-Macrophage Colony-Stimulating Factor