title: [Evaluation of latent changes in blood coagulation by the determination of plasma thrombin-antithrombin complex in gastrointestinal neoplasms].
abstract: The relationship between cancer and coagulation disorders is widely accepted. Such disorders can contribute to the metastatic spreading of the primary tumor. Aim of our study was to evaluate the alterations of thrombin-antithrombin III complex (TAT) measured by an ELISA plasma assay in a population of 78 patients suffering from various gastrointestinal tumors. We found high levels of TAT in 68.6% of the patients. Our data show that assay of TAT plasma levels may be a useful test in detecting early coagulation disorders in cancer patients.
authors.affiliation: Facoltà di Medicina e Chirurgia, Istituto di Clinica Medica Generale e Terapia Medica, Università Cattolica del Sacro Cuore di Roma.
authors.forename: L
authors.initials: L
authors.lastname: Guidi
authors.forename: C
authors.initials: C
authors.lastname: Bartoloni
authors.forename: P
authors.initials: P
authors.lastname: Pellicanò
authors.forename: A
authors.initials: A
authors.lastname: Cappelli
authors.forename: F
authors.initials: F
authors.lastname: Cursi
authors.forename: R
authors.initials: R
authors.lastname: Pili
authors.forename: A
authors.initials: A
authors.lastname: Tricerri
authors.forename: F
authors.initials: F
authors.lastname: Patriarca
authors.forename: G
authors.initials: G
authors.lastname: Gambassi
mesh_terms: D000990:Antithrombin III / Q000032:analysis*; D001661:Biliary Tract Neoplasms / Q000097:blood / Q000175:diagnosis; D014408:Biomarkers, Tumor; D001778:Blood Coagulation Disorders / Q000175:diagnosis*; D003110:Colonic Neoplasms / Q000097:blood / Q000175:diagnosis; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005770:Gastrointestinal Neoplasms / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis; D010447:Peptide Hydrolases / Q000032:analysis*; D013274:Stomach Neoplasms / Q000097:blood / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases
vernacular_title: Valutazione di alterazioni latenti della coagulazione mediante il dosaggio plasmatico del complesso trombina antitrombina nelle neoplasie gastrointestinali.