Platelet [3H]imipramine and alpha 2-adrenoceptor binding in normal subjects during desipramine administration and withdrawal.
The effect of desipramine 150 mg daily on platelet [3H]imipramine and alpha 2-adrenoceptor binding sites was studied over a 6-week period and for 6 weeks after withdrawal. Modest (10%) increases in [3H]imipramine binding site densities during treatment were noted with a decrease between 1 and 4 weeks after withdrawal. No effect was found on alpha 2-adrenoceptors. Time of day appeared to have some effect on the results found. None of the [3H]imipramine binding site effects of desipramine, on treatment or following withdrawal, was comparable in magnitude to trait differences that were also found between subjects.
Healy
D T
DT
Department of Psychiatry, University of Wales, Clwyd, UK.
Paykel
E S
ES
Whitehouse
A M
AM
White
W
W
Wilton-Cox
H
H
Johnson
A L
AL
Theodorou
A E
AE
Lawrence
K
K
Horton
R W
RW
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D003891:Desipramine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011869:Radioligand Assay; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D012016:Reference Values; D013997:Time Factors
D011942:Receptors, Adrenergic, alpha; D007099:Imipramine; D003891:Desipramine