Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B beta.
Complementary DNA coding for a catalytic subunit of protein phosphatase 2B was isolated from a human teratocarcinoma library. It encodes a third isoform of protein phosphatase 2B beta, and differs from the cDNA for the second isoform by a deletion of 30 base pairs in the coding region. The deletion results in the loss of ten amino acids between the putative calmodulin site and a postulated autoinhibitory domain. An identical deletion occurs in one of the two alternatively spliced isoforms of PP2B alpha.
McPartlin
A E
AE
Department of Biochemistry, The University, Dundee, U.K.
Barker
H M
HM
Cohen
P T
PT
D000595:Amino Acid Sequence; D001483:Base Sequence; D001921:Brain / Q000201:enzymology; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D004273:DNA, Neoplasm / Q000235:genetics*; D015723:Gene Library; D006801:Humans; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D012326:RNA Splicing; D012689:Sequence Homology, Nucleic Acid; D013724:Teratoma / Q000201:enzymology
D002148:Calmodulin-Binding Proteins; D004273:DNA, Neoplasm; D046911:Macromolecular Substances; D015345:Oligonucleotide Probes; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases