Gamma interferon expression and major histocompatibility complex induction during measles and vesicular stomatitis virus infections of the brain.
Lymphocytic interferon gamma (IFN-gamma) production and major histocompatibility complex (MHC) antigen induction were studied in experimental measles and vesicular stomatitis virus infections in the brain. Fifteen-day-old Sprague-Dawley rats injected intracerebrally with the HNT strain of measles virus showed already within 1 day after infection an increased number of cells producing IFN-gamma in the spleen, cervical lymph nodes and leptomeninges. These rats recovered after a transient neuronal infection in the brain. Rats infected intracerebrally with vesicular stomatitis virus, on the other hand, all succumbed after 2 days and showed no IFN-gamma production in lymphoid cells. Immunohistochemically MHC class I antigen appeared in infected and uninfected cells in the brain during replication of both viruses. A role for the recently discovered nerve fibres with IFN-gamma-like immunoreactivity, which are normally present in the brain, in the MHC antigen induction is discussed.
Gogate
N
N
Department of Cellular and Neuropathology, Huddinge Hospital, Sweden.
Bakhiet
M
M
Kristensson
K
K
Norrby
E
E
Olsson
T
T
D000818:Animals; D001921:Brain / Q000276:immunology; D004660:Encephalitis / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000096:biosynthesis*; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000032:analysis / Q000096:biosynthesis*; D008457:Measles / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D014721:Vesicular stomatitis Indiana virus; D014777:Virus Diseases / Q000276:immunology*
D006649:Histocompatibility Antigens; D007371:Interferon-gamma