Platelet peripheral benzodiazepine receptors in repeated stress.
[3H]PK 11195 binding to platelet membranes and plasma stress hormones were studied in soldiers at the beginning of a parachute training course, following 6 days of preparatory exercises, and after the fourth actual parachute jump. A slight reduction (15%; NS) in the number of peripheral benzodiazepine receptors (PBR) was detected at the end of the exercise period, prior to the first jump. Reduced (26%; P less than 0.05) density of PBR was observed immediately after the repeated actual jumps. Equilibrium dissociation constants were not affected by the stressful situation. Plasma cortisol and prolactin levels remained unaltered during the entire study period.
Dar
D E
DE
Department of Pharmacology, Faculty of Medicine, Technion-Israel, Institute of Technology, Haifa.
Weizman
A
A
Karp
L
L
Grinshpoon
A
A
Bidder
M
M
Kotler
M
M
Tyano
S
S
Bleich
A
A
Gavish
M
M
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007546:Isoquinolines / Q000378:metabolism; D008297:Male; D011388:Prolactin / Q000097:blood; D011863:Radioimmunoassay; D011963:Receptors, GABA-A / Q000378:metabolism*; D012016:Reference Values; D013312:Stress, Physiological / Q000097:blood*
D007546:Isoquinolines; D011963:Receptors, GABA-A; D011388:Prolactin; D006854:Hydrocortisone; C037850:PK 11195