[Factor VIII inhibitors in non-hemophiliac patients. A report of cases and therapeutic prospects].
Approximately 5-20% of patients with hemophilia A acquire antifactor VIII antibodies during transfusion therapy. These autoantibodies cause serious bleeding and are rarely found in non hemophiliac patients (only a few hundred case reports in the literature). Treatment of this autoimmune condition is quite difficult: corticosteroids, immunosuppressive agents, plasmapheresis and transfusions may be useful. We describe two patients we observed and add some general reflections on therapy.
Haupt
E
E
Divisione di Medicina di Sestri Levante, USL 18, Regione Liguria.
Rolandelli
M L
ML
Bardellini
G
G
Raffo
A
A
Mencoboni
M
M
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000628:therapy; D001803:Blood Transfusion; D005169:Factor VIII / Q000276:immunology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D010956:Plasmapheresis; D011379:Prognosis
D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D007166:Immunosuppressive Agents; D005169:Factor VIII
Inibitori del fattore VIII in pazienti non emofilici. Segnalazione di due casi e prospettive terapeutiche.