Nucleotide sequence to a teicoplanin resistance gene from Actinoplanes teichomyceticus.
A DNA fragment, isolated from A. teichomyceticus and able to confer teicoplanin resistance in a sensitive host, has been sequenced. It reveals the presence of two open reading frames (ORFs) positioned on opposite strands, named ORF1 and ORF2. ORF2 seems to be responsible for the acquisition of the resistance character.
Sosio
M
M
Lepetit Research Center, M.M.D.R.I., Gerenzano, Italy.
Lorenzetti
R
R
Robbiati
F
F
Denaro
M
M
D000192:Actinomycetales / Q000235:genetics*; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents; D001483:Base Sequence; D003001:Cloning, Molecular; D004269:DNA, Bacterial; D004352:Drug Resistance, Microbial / Q000235:genetics; D005798:Genes, Bacterial; D006020:Glycopeptides / Q000494:pharmacology; D008969:Molecular Sequence Data; D015183:Restriction Mapping; D013302:Streptomyces / Q000235:genetics; D017334:Teicoplanin
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D006020:Glycopeptides; D017334:Teicoplanin