Synthesis of purine bases having a di(hydroxymethyl)cyclopentenyl group by means of high-pressure reaction and their anti-HIV activity.
The 1'- and 5'-hydroxymethyl derivatives of carbovir and related purine derivatives were synthesized from 5-hydroxymethylcyclopentadiene. The anti-HIV activity evaluation of these compounds has revealed that 9-(c-4,t-5-dihydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine is a prospective chemotherapeutic agent against AIDS.
Katagiri
N
N
Pharmaceutical Institute, Tohoku University, Sendai, Japan.
Nomura
M
M
Sato
H
H
Tameda
C
C
Kurimoto
A
A
Arai
S
S
Toyota
A
A
Kaneko
C
C
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015224:Dideoxynucleosides / Q000737:chemistry* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D015394:Molecular Structure; D011446:Prospective Studies
D000998:Antiviral Agents; D015224:Dideoxynucleosides; C057503:carbovir; C051061:oxetanocin; D000225:Adenine; D000241:Adenosine; C014174:psicofuranine