title: Responses of neutrophils and lymphocytes in the cold stress: effects of nonsteroid anti-inflammatory drugs.
abstract: The cold stress induced in rabbits by lowering their body temperature by 3 degrees C resulted in neutrophilia and a decrease in number of phagocytes and phagocytized bacteria. The stress did not affect the number of lymphocytes and the ability of forming E rosettes by T lymphocytes, but depressed the formation of EAC rosettes by B lymphocytes. This inhibition of neutrophil activity was antagonized completely by acetylsalicylic acid, and substantially by mefenamic acid and indomethacin administered, in doses inhibiting pyrogen-induced fever, either 2.5 h before or 1.5 h after the hypothermia. The drugs did not antagonize the depression of the ability of formation of EAC rosettes.
authors.affiliation: Department of Pharmacology and Toxicology, Agricultural Academy, Wrocław, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Garbuliński
authors.forename: B
authors.initials: B
authors.lastname: Obmińska-Domoradzka
authors.forename: M
authors.initials: M
authors.lastname: Switała
authors.forename: J
authors.initials: J
authors.lastname: Debowy
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D003080:Cold Temperature; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects; D011817:Rabbits; D013312:Stress, Physiological / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal