MHC class I restricted T cells and immune surveillance against transplanted ultraviolet light-induced tumors.
Studies involving tumor escape from host immune surveillance have focused heavily on loss of major histocompatibility class I antigens as well as loss of tumour-associated antigens as possible mechanisms by which tumors escape recognition and lysis by cytolytic T cells. Examples of both phenomena are found in murine tumors induced by viruses, chemical mutagens, a spontaneous tumor mutagenized in vitro and some u.v.-induced tumors. However, evidence also exists for the escape of tumors from immune destruction without loss of major histocompatibility class I molecules or tumor antigens and additional mechanisms undoubtedly are involved in the complex phenomena of tumor progression.
Ward
P L
PL
Department of Pathology, University of Chicago, IL 60637.
Schreiber
H
H
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology*; D016867:Immunocompromised Host; D007157:Immunologic Surveillance; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D008819:Mice, Nude / Q000276:immunology; D009374:Neoplasms, Experimental / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000951:Antigens, Neoplasm; D006183:H-2 Antigens