Suppression of atherogenesis by n-3 fatty acids in the cholesterol-fed rabbit.
The effects of n-3 fatty-acid supplementation on serum lipids, platelet aggregation, and the development of atherosclerotic lesions were studied in the cholesterol-fed rabbit. Serum total cholesterol and LDL cholesterol values were significantly reduced in comparison with those of the nonsupplemented cholesterol-fed group (p less than 0.005, p less than 0.0025, respectively), though still higher than those of the control group (p less than 0.0025, p less than 0.0125 respectively). Platelet aggregation was reduced below that of the cholesterol-fed and the control levels (p less than 0.0005, p less than 0.0025, respectively). The endothelial injury encountered in cholesterol-fed rabbits was inhibited in the supplemented group. It is concluded that n-3 fatty acids suppress atherogenesis in this animal model by interfering with platelet aggregation and lipid metabolism.
Demiroglu
C
C
Institute of Cardiology, Istanbul Medical Faculty, University of Istanbul, Turkey.
Ozder
A
A
Altug
T
T
Orbay
B
B
Satar-Yíldírím
S
S
Bilir
A
A
Deniz
G
G
Erbengi
T
T
Büyükdevrim
S
S
D000818:Animals; D001158:Arteries / Q000187:drug effects; D001161:Arteriosclerosis / Q000097:blood / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits
D008055:Lipids; D010975:Platelet Aggregation Inhibitors; D004281:Docosahexaenoic Acids; D002784:Cholesterol; D015118:Eicosapentaenoic Acid