Quinolones do not interact with NMDA receptor in dissociated rat hippocampal neurons.
Interaction of quinolone antimicrobials and fenbufen, anti-inflammatory agents, with the N-methyl-D-aspartate (NMDA) receptor was investigated in rat hippocampal neurons with the conventional patch-clamp technique. Simultaneous applications of quinolones and a metabolite of fenbufen had no effects on the glutamate- and NMDA-induced currents. The blocking effects of Mg2+ and MK-801 on NMDA responses were also unaffected. Therefore, the convulsive action induced by quinolones and fenbufen does not seem to involve the function change of NMDA receptor.
Shirasaki
T
T
Department of Neurophysiology, Tohoku University School of Medicine, Sendai, Japan.
Harata
N
N
Nakaye
T
T
Akaike
N
N
D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016291:Dizocilpine Maleate / Q000378:metabolism; D004347:Drug Interactions; D006624:Hippocampus / Q000378:metabolism*; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism*; D010654:Phenylbutyrates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000378:metabolism
D042462:4-Quinolones; D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010654:Phenylbutyrates; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; C010725:fenbufen; D008274:Magnesium