title: Anti-anginal efficacy of intravenous amlodipine assessed by means of atrial pacing.
abstract: The anti-anginal efficacy of amlodipine was investigated in patients with angina pectoris by means of atrial pacing during cardiac catheterization. Intravenous administration of amlodipine significantly increased the time to pacing-induced angina and reduced the area of ST-segment change for an equivalent pacing rate, suggesting an improvement in this functional marker of ischaemia. In addition, a significant reduction in the double product suggests that amlodipine reduced myocardial oxygen consumption.
authors.affiliation: Department of Materia Medica, Stobhill General Hospital, Glasgow, UK.
authors.forename: K J
authors.initials: KJ
authors.lastname: Hogg
authors.forename: R S
authors.initials: RS
authors.lastname: Hornung
authors.forename: W S
authors.initials: WS
authors.lastname: Hillis
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: P
authors.initials: P
authors.lastname: Grant
authors.forename: S P
authors.initials: SP
authors.lastname: Singh
mesh_terms: D017311:Amlodipine; D000787:Angina Pectoris / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D006801:Humans; D007275:Injections, Intravenous; D009543:Nifedipine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D002121:Calcium Channel Blockers; D017311:Amlodipine; D009543:Nifedipine