Regulation and biological function of helminth-induced cytokine responses.
The immunological hallmarks of infection with parasitic helminths, namely eosinophilia, mastocytosis and increased IgE synthesis, all appear to be induced by cytokines from the TH2 subset of CD4+ T cells: IgE production is stimulated by interleukin 4 (IL-4), eosinophilia by IL-5 and mastocytosis by IL-3 and IL-4. Here, Fred Finkelman and colleagues argue that the functional significance of the eosinophilia-mastocytosis-IgE axis in helminth infection is unclear and suggest that in some worm infections TH2-cell cytokines may contribute to host protection, while in others they may promote parasite survival.
Finkelman
F D
FD
Dept of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889.
Pearce
E J
EJ
Urban
J F
JF
Sher
A
A
D000818:Animals; D005075:Biological Evolution; D016207:Cytokines / Q000378:metabolism / Q000502:physiology*; D004802:Eosinophilia / Q000209:etiology / Q000473:pathology; D004804:Eosinophils / Q000276:immunology; D005786:Gene Expression Regulation; D006373:Helminthiasis / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007371:Interferon-gamma / Q000502:physiology; D007376:Interleukin-2 / Q000502:physiology; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D007376:Interleukin-2; D007073:Immunoglobulin E; D007371:Interferon-gamma