Cardio-facio-cutaneous (CFC) syndrome: report of two patients without hyperkeratotic skin lesions.
We report on two boys with the cardio-faciocutaneous (CFC) syndrome, but without hyperkeratotic skin involvement. They showed most of the manifestations of the CFC syndrome: growth and developmental retardation, relative macrocephaly, distinct facial appearance, sparse hair, and heart defects. Their skin was not hyperkeratotic, but patient 1 had mild atopic dermatitis and keloid-like depigmented spots.
Matsuda
Y
Y
Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Japan.
Murano
I
I
Kondoh
O
O
Matsuo
K
K
Kajii
T
T
D000015:Abnormalities, Multiple / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005147:Facial Bones / Q000002:abnormalities*; D006801:Humans; D007642:Keratosis / Q000473:pathology; D008297:Male; D012868:Skin Abnormalities; D012886:Skull / Q000002:abnormalities*; D013577:Syndrome