title: Analysis of tissue platinum distribution in patients with cancer of the oesophagus.
abstract: The objective of this work has been to analyse the repartition of platinum (Pt) tissular levels within the tumour (T), the peritumoral adjacent non-tumoral area (P) and distant healthy tissue of the same anatomical zone (H) in oesophagus cancer. Forty-two biopsies (congruent to 5 mg) have been performed under endoscopy and after informed consent in 11 patients (mean age 61 yr, range 43-74) with squamous cell carcinoma of the oesophagus treated by the neoadjuvant chemotherapy protocol including cisplatin (100 mg/m2) and 5-FU (1 g/m2 x 5 days). Biopsies were done 34-36 h after cisplatin. Additional biopsies were obtained for histological controls. Pt was measured by flameless atomic absorption spectrometry. Considering Pt concentration in T, P and H there was no significant accumulation during repeated treatment (3 cycles). For all cycles, mean [S.D.] values (micrograms/g dry tissue) were 2.03 [2.39] for H, 2.75 [2.03] for P and 3.73 [2.3] for T (H vs. T, P = 0.006). In addition, Pt concentrations were found comparable between the upper and lower poles of the tumours (5 patients). Pt concentrations in T did not predict antitumour activity. These data complete the rather limited knowledge on tissular Pt levels in treated patients and suggest a decreasing gradient of Pt concentrations from tumour to healthy tissue in oesophagus cancer.
authors.affiliation: Institut Jules Bordet, Bruxelles, Belgium.
authors.forename: V
authors.initials: V
authors.lastname: Troger
authors.forename: E
authors.initials: E
authors.lastname: Francois
authors.forename: M
authors.initials: M
authors.lastname: Frenay
authors.forename: M
authors.initials: M
authors.lastname: Namer
authors.forename: G
authors.initials: G
authors.lastname: Milano
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D002945:Cisplatin / Q000493:pharmacokinetics / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000737:chemistry* / Q000188:drug therapy; D004947:Esophagus / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D010984:Platinum / Q000032:analysis*
chemical_list: D010984:Platinum; D002945:Cisplatin