Differentiation of human embryonal carcinoma cells induces human immunodeficiency virus permissiveness which is stimulated by human cytomegalovirus coinfection.
Human immunodeficiency virus (HIV) replicates in differentiated but not undifferentiated NTERA-2 human embryonal carcinoma cells; neither cell type expresses CD4. Susceptibility of the differentiated cells is enhanced by coinfection with cytomegalovirus. HIV infection induces lactoseries glycolipids, suggesting a mechanism whereby HIV might interfere with normal embryogenesis.
Hirka
G
G
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104-4268.
Prakash
K
K
Kawashima
H
H
Plotkin
S A
SA
Andrews
P W
PW
Gönczöl
E
E
D000911:Antibodies, Monoclonal / Q000276:immunology; D015152:Blotting, Northern; D015704:CD4 Antigens / Q000276:immunology; D002454:Cell Differentiation; D003587:Cytomegalovirus / Q000502:physiology*; D054278:Embryonal Carcinoma Stem Cells; D015683:Gene Products, gag / Q000032:analysis; D006678:HIV / Q000502:physiology*; D015488:HIV Antigens / Q000032:analysis; D016655:HIV Core Protein p24; D006801:Humans; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000382:microbiology; D014758:Viral Core Proteins / Q000032:analysis; D014779:Virus Replication
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D015683:Gene Products, gag; D015488:HIV Antigens; D016655:HIV Core Protein p24; D014758:Viral Core Proteins