Effective photocleavage of DNA by pheophorbide a.
Remarkably effective photocleavage of plasmid DNA with pheophorbide a, as a visible light sensitizer, has been found for the first time. DNA is photocleaved even in the absence of oxygen. The novel oxygen-independent scission is ascribed to specific photodynamic function of the ring V in pheophorbide a.
Kobayashi
M
M
Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo, Japan.
Harada
M
M
Komiyama
M
M
D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D015394:Molecular Structure; D010100:Oxygen; D010777:Photochemistry; D010957:Plasmids / Q000187:drug effects*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
D011838:Radiation-Sensitizing Agents; D002734:Chlorophyll; D004247:DNA; C032623:pheophorbide a; D010100:Oxygen