Isolated ACTH deficiency with absent response to corticotrophin-releasing factor--41. Evidence for a primary pituitary defect.
An 8-year-old girl presenting in hypoglycaemic coma was shown to have isolated deficiency of adrenocorticotrophic hormone (ACTH) secretion. Failure to secrete ACTH in response to intravenous administration of synthetic ovine corticotrophin-releasing factor (CRF-41) suggests that this disorder was due to a primary pituitary defect, rather than of hypothalamic origin.
Murch
S H
SH
Department of Child Health, St. Bartholomew's Hospital, London, UK.
Carter
E P
EP
Tsagarakis
S
S
Grossman
A
A
Savage
M O
MO
D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D002648:Child; D003346:Corticotropin-Releasing Hormone; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis* / Q000209:etiology; D010900:Pituitary Diseases / Q000150:complications / Q000175:diagnosis*; D010901:Pituitary Function Tests
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone