title: Fixed drug eruption from pamabrom.
abstract: A young woman presented with recurrent skin lesions that were predominantly perioral. Fixed drug reaction was diagnosed based on her history of intermittent ingestion of Pamprin, a common menstrual symptom reliever, and characteristic erythematous, pigmented, edematous patches. After oral challenge with two of the three ingredients in Pamprin, a diagnosis of fixed drug reaction to pamabrom was made. Pamabrom is a mild diuretic present in several over-the-counter and prescription menstrual symptom relievers. This is the first reported case of fixed drug reaction to pamabrom.
authors.affiliation: Department of Dermatology, Cleveland Clinic Foundation, Ohio 44195.
authors.forename: S
authors.initials: S
authors.lastname: Nedorost
authors.forename: J S
authors.initials: JS
authors.lastname: Taylor
authors.forename: C
authors.initials: C
authors.lastname: Camisa
authors.forename: K J
authors.initials: KJ
authors.lastname: Tomecki
authors.forename: T
authors.initials: T
authors.lastname: Helm
authors.forename: W J
authors.initials: WJ
authors.lastname: Durkin
mesh_terms: D000328:Adult; D004338:Drug Combinations; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects; D011412:Propanolamines / Q000009:adverse effects* / Q000627:therapeutic use; D012883:Skin Ulcer / Q000139:chemically induced*; D013806:Theophylline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D011412:Propanolamines; D013806:Theophylline; C069987:pamabrom