[Determination of sex and Y chromosome].
Years of speculations about the nature of the elusive testis determining factor (TDF) of the Y chromosome have ended last year. A gene named SRY satisfies many criteria expected of the testis determining gene, and gives us a basis to understand molecular mechanisms of the testis differentiation. The different steps which gave rise to SRY cloning are described.
Poulat
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F
CRBM-CNRS UPR 8402, INSERM U 249, Montpellier.
Berta
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P
D004268:DNA-Binding Proteins / Q000235:genetics; D005796:Genes / Q000235:genetics; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D012732:Sex Determination Analysis; D012733:Sex Differentiation / Q000235:genetics; D014157:Transcription Factors; D014998:Y Chromosome / Q000648:ultrastructure*
D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C054430:ZFY protein, human
Détermination du sexe et chromosome Y.