Difluoromethyl ornithine protects against the neurotoxic effects of intrastriatally administered N-methyl-D-aspartate in vivo.
The neurotoxic effects of intrastriatally administered N-methyl-D-aspartate (NMDA) (250 nmol), as measured by reductions in striatal choline acetyl transferase activity and by increased binding of the glial marker [3H]PK 11195 10 days later, were reduced by coinfusion of the irreversible ornithine decarboxylase inhibitor difluoromethylornithine (250 nmol) in the rat. The data suggest a crucial role for the polyamines in NMDA receptor-mediated neurotoxicity.
Porcella
A
A
Synthélabo Recherche (L.E.R.S.), Bagneux, France.
Fage
D
D
Voltz
C
C
Carter
C
C
Scatton
B
B
Bartholini
G
G
D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D000518:Eflornithine / Q000494:pharmacology*; D007546:Isoquinolines / Q000378:metabolism; D008297:Male; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects
D007546:Isoquinolines; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D002795:Choline O-Acetyltransferase; C037850:PK 11195; D000518:Eflornithine