title: Action of synthetic atrial natriuretic factor on contractility and coronary perfusion in isolated working rat hearts.
abstract: The effects of atrial natriuretic factor were studied in isolated working rat hearts. Increasing concentrations, from 0.1 to 100 nM, of a synthetic rat-ANF (atrial natriuretic factor) were added to the perfusate. ANF had no effect on heart rate, contraction cycle or coronary resistance in concentrations up to 3 nM. At concentrations above 10 nM, peak dP/dt and oxygen consumption showed a slight dose-dependent increase. The greater decrease in coronary resistance, and the lowering of coronary oxygen extraction, suggest that ANF has a small coronary dilating effect. No arrhythmias were observed at any concentration of ANF.
authors.affiliation: Institut für Pharmakologie, Bayer AG, Wuppertal, F.R.G.
authors.forename: J F
authors.initials: JF
authors.lastname: Hütter
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: C472610:atrial natriuretic peptide, rat; D009320:Atrial Natriuretic Factor