title: Expression of a fetal gamma delta T-cell receptor in adult mice triggers a non-MHC-linked form of selective depletion.
abstract: Day 14 fetal thymocytes and adult dendritic epidermal T cells (dEC) of all mouse strains express a characteristic non-polymorphic gamma delta T-cell receptor which is rarely found in the adult thymus or lymph nodes. We have made transgenic mice expressing this particular set of receptors on T cells in C3H and C57BL/6 mice. In adult mice of the latter strain, a dramatic depletion of transgene expressing T cells occurs and this effect is primarily mediated by thymic radiosensitive cells. The depletion is genetically dominant but not MHC-linked with major factor(s) mapping to chromosome 18. Taken together, our results show that strain-specific developmental changes in the thymic environment may play a role in shaping the gamma delta TCR repertoire.
authors.affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, CA.
authors.forename: M
authors.initials: M
authors.lastname: Iwashima
authors.forename: A
authors.initials: A
authors.lastname: Green
authors.forename: M
authors.initials: M
authors.lastname: Bonyhadi
authors.forename: M M
authors.initials: MM
authors.lastname: Davis
authors.forename: J P
authors.initials: JP
authors.lastname: Allison
authors.forename: Y H
authors.initials: YH
authors.lastname: Chien
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D005333:Fetus / Q000276:immunology*; D005799:Genes, Dominant; D008212:Lymphocyte Depletion; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D011836:Radiation Tolerance; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects
chemical_list: D011948:Receptors, Antigen, T-Cell; D016692:Receptors, Antigen, T-Cell, gamma-delta