Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.
Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.
Acha-Orbea
H
H
Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
Shakhov
A N
AN
Scarpellino
L
L
Kolb
E
E
Müller
V
V
Vessaz-Shaw
A
A
Fuchs
R
R
Blöchlinger
K
K
Rollini
P
P
Billotte
J
J
D000595:Amino Acid Sequence; D000818:Animals; D002872:Chromosome Deletion; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005814:Genes, Viral; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010641:Phenotype; D011533:Proviruses / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell