The mouse factor H allotypes with multiple amino acid replacement, H.1 and H.2 show indistinguishable co-factor activity for factor I.
The authors report the functional analysis of the purified mouse factor H allotypes H.1 and H.2, which were clearly distinguished from each other by an immunodiffusion test. Both allotypes acted as a co-factor for factor I in cleaving mouse C3b and we found no significant difference between their activities. The results strongly suggest that the function of mouse factor H for the co-factor activity has been well conserved between two allotypes.
Natsuume-Sakai
S
S
Department of Immunobiology, Kanazawa University, Japan.
Okada
M
M
Seya
T
T
Nonaka
M
M
Harada
Y
Y
Moriwaki
K
K
D000483:Alleles; D000818:Animals; D003180:Complement C3b Inactivator Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D017242:Complement Factor H; D017244:Complement Factor I; D051379:Mice; D008970:Molecular Weight; D012697:Serine Endopeptidases / Q000502:physiology*; D014162:Transfection
D003180:Complement C3b Inactivator Proteins; D017242:Complement Factor H; D012697:Serine Endopeptidases; D017244:Complement Factor I