Pristane-induced arthritis in mice. III. Lymphocyte phenotypic and functional abnormalities precede the development of pristane-induced arthritis.
Pristane injection caused mediastinal lymphadenopathy in arthritis-susceptible DBA/1 mice, but not in arthritis-resistant DBA/2 mice. Early DBA/1 mediastinal lymph node changes were characterized by the accumulation of surface Ig+ cells and a CD8+ (Lyt 2) lymphocyte population, causing an inversion of the CD4/CD8 ratio. Depressed mitogen responses and the appearance of a nonspecific suppressor cell population were coincidental with the CD8+ cell accumulation. Prior to the development of overt clinical arthritis, an expansion of CD4+ (L3T4) lymphocytes displaced CD8+ as the predominant phenotype in mediastinal node. Mitogen responses were restored and suppressor cell activity was abrogated concomitant with the expansion of the CD4+ cell population.
Wooley
P H
PH
Department of Internal Medicine, Wayne State University Medical School, Detroit, Michigan 48202.
Whalen
J D
JD
D000818:Animals; D001168:Arthritis / Q000139:chemically induced*; D016516:CD4-CD8 Ratio / Q000187:drug effects; D008206:Lymphatic Diseases / Q000139:chemically induced; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008811:Mice, Inbred DBA; D010641:Phenotype; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects; D013729:Terpenes / Q000633:toxicity*
D013729:Terpenes; C009042:pristane