title: Analysis of two types of dopaminergic responses of neurons of the spinal ganglia of rats.
abstract: It was established, in experiments on isolated spinal ganglia of adult rats in conditions of intracellular recording, that dopamine (1 microM/liter) elicits depolarized responses in 61% of neurons, hyperpolarized in 20% of neurons, and depolarized-hyperpolarized in 19% of neurons. The depolarized responses are associated with the activation of D1 dopamine receptors, and are governed by the shift of cAMP-dependent cation (sodium) channels to the conducting state. The hyperpolarized responses are triggered by the activation of D2 dopamine receptors, which by means of HTP-binding protein convert the potassium channels to the conducting state. The change in the polarization of neurons with the action of dopamine influences their electrical excitability variously.
authors.affiliation: Department of Pharmacology, M. Gor'kii State Medical Institute, Donetsk.
authors.forename: I I
authors.initials: II
authors.lastname: Abramets
authors.forename: I M
authors.initials: IM
authors.lastname: Samoilovich
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D005727:Ganglia, Spinal / Q000502:physiology*; D007093:Imidazoles / Q000494:pharmacology; D066298:In Vitro Techniques; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*; D011188:Potassium / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D017448:Receptors, Dopamine D2; D013469:Sulpiride / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
chemical_list: D007093:Imidazoles; D015221:Potassium Channels; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D010566:Virulence Factors, Bordetella; D013469:Sulpiride; D013806:Theophylline; D011188:Potassium; D004298:Dopamine