[Effect of molsidomine infusion on thrombocyte function in acute myocardial infarct].
In 10 patients with acute myocardial infarction i.v. molsidomine was given over 48 h and a number of platelet functions was evaluated before and 3, 24, and 48 h after therapy. There was a significant prolongation of template bleeding time from 290 s to 400 s. The amplitude of spontaneous and induced platelet aggregation remained unchanged. In four of the 10 patients initially high plasma concentrations of beta-TG and PF4, and high serum concentrations of TxB2, decreased, indicating an effect of molsidomine in states of hyperreactive platelets.
Hiller
E
E
Medizinische Klinik III im Klinikum Grosshadern der LMU Müchen.
Fischer
U
U
von Essen
R
R
Riess
H
H
D000368:Aged; D001760:Bleeding Time; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008981:Molsidomine / Q000008:administration & dosage*; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D013929:Thromboxane B2 / Q000097:blood; D001620:beta-Thromboglobulin / Q000378:metabolism
D001620:beta-Thromboglobulin; D013929:Thromboxane B2; D008981:Molsidomine
Einfluss der Molsidomininfusion auf die Thrombozytenfunktion beim akuten Myokardinfarkt.