title: [Delayed hypersensitivity to protamine and immediate hypersensitivity to insulin].
abstract: A 63-year-old female, with type II diabetes mellitus, diagnosed in 1967, was started on combination therapy with sulphonylureas and human depot insulin in May 1989, because of inadequate blood sugar control with sulphonylureas alone. Within 3 months she began to develop nodular skin reactions at the site of injection, 12-24 hours after insulin injections. Intradermal testing demonstrated delayed (Gell and Coombs type IV) hypersensitivity to protamine. No specific IgE or IgG antibodies were demonstrable. She was changed to protamine-free human delayed action insulin. After an initial reaction-free period, red urticarial lesions, attributable to immediate (Gell and Coombs type I) hypersensitivity to human insulin, appeared at the injection sites. There were no other complications with continued insulin therapy, and after about 6 weeks no further local reactions were detectable. When an allergic reaction to an insulin preparation is suspected, careful immunological investigation should be performed, to ensure adequate treatment without risk to the patient.
authors.affiliation: Klinik für Dermatologie und Allergologie, St.-Barbara-Hospital Duisburg.
authors.forename: A
authors.initials: A
authors.lastname: Köllner
authors.forename: H
authors.initials: H
authors.lastname: Senff
authors.forename: L
authors.initials: L
authors.lastname: Engelmann
authors.forename: K J
authors.initials: KJ
authors.lastname: Kalveram
authors.forename: H G
authors.initials: HG
authors.lastname: Velcovsky
authors.forename: E
authors.initials: E
authors.lastname: Haneke
mesh_terms: D003692:Delayed-Action Preparations; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D006969:Hypersensitivity, Immediate / Q000139:chemically induced*; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D011479:Protamines / Q000009:adverse effects*; D012882:Skin Tests; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D007328:Insulin; D011479:Protamines
vernacular_title: Protaminallergie vom Spättyp und Insulinallergie vom Soforttyp.