Synthetic study on 4C'-methyl nucleosides: Part I, Synthesis of 4C-methyl-D-ribofuranose derivative.
The 4C-methyl-D-ribofuranose derivative, a key intermediate for the synthesis of 4C'-methyl nucleosides, was prepared from D-glucose via regioselective benzylation of hydroxymethyl groups and the reduction of iodide made from the remaining hydroxymethyl group.
Ohrui
H
H
Tohoku University, Sendai, Japan.
Nishizaki
T
T
Waga
T
T
Meguro
H
H
D008745:Methylation; D015394:Molecular Structure; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D012263:Ribonucleosides; C077691:3,5-di-O-benzyl-1,2-isopropylidene-4C-methylribofuranose