[Soluble CD23: cytokine actives on human hematopoietic precursors].
We report herein the effect of soluble CD23 (sCD23) on the differentiation of early lymphoid and myeloid human precursors. CD23 is known as a low affinity receptor for IgE. In addition, our results show that sCD23 in synergy with IL1 has a potent activity on the maturation of prothymocytes and the proliferation of multipotential normal and leukemic myeloid precursors.
Mossalayi
M D
MD
Laboratoire d'Immunologie Cellulaire et Tissulaire, CNRS URA 625, Hôpital Pitié-Salpêtrière, Paris, France.
Dalloul
A H
AH
Debré
P
P
D015703:Antigens, CD / Q000276:immunology*; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D016207:Cytokines / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000378:metabolism
D015703:Antigens, CD; D016207:Cytokines
Le CD23 soluble: une cytokine active sur les précurseurs hématopoïétiques humains.