title: Pharmacokinetics of arteether in dog.
abstract: A pharmacokinetic study has been conducted in six beagle dogs after i.m. administration of 25 mg/kg of arteether, a qinghaosu (artemisinin) derivative of high anti-malarial activity. Arteether plasma concentrations were measured during a 24 h period using HPLC with an electrochemical detector in the reductive mode. The pharmacokinetic parameters were established using an open two-compartment model. Results showed a relatively rapid absorption phase: T1/2ka was 0.300 +/- 0.096 h and a mean elimination half-life of 27.95 +/- 11.93 h. Cmax was 110 +/- 16 ng/ml, Cltot/F was 1.69 +/- 0.34 ml/min and AUC was 2797 +/- 476 ng/ml/h.
authors.affiliation: Department of Pharmacology, University of Geneva, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Benakis
authors.forename: C
authors.initials: C
authors.lastname: Schopfer
authors.forename: M
authors.initials: M
authors.lastname: Paris
authors.forename: C T
authors.initials: CT
authors.lastname: Plessas
authors.forename: P E
authors.initials: PE
authors.lastname: Karayannakos
authors.forename: I
authors.initials: I
authors.lastname: Dondas
authors.forename: D
authors.initials: D
authors.lastname: Kotsarelis
authors.forename: S T
authors.initials: ST
authors.lastname: Plessas
authors.forename: G
authors.initials: G
authors.lastname: Skalkeas
mesh_terms: D000818:Animals; D037621:Artemisinins; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D004563:Electrochemistry; D005260:Female; D006207:Half-Life; D007273:Injections, Intramuscular; D008297:Male; D008954:Models, Biological; D012717:Sesquiterpenes / Q000493:pharmacokinetics*
chemical_list: D037621:Artemisinins; D012717:Sesquiterpenes; C055141:artemotil