The effects of erythrosine on alveolar bone and gingival connective tissue in dogs.
This study was conducted to determine if erythrosine had any effect when placed in contact with alveolar bone and gingival connective tissue in dogs in conjunction with a periodontal surgical procedure. Periodontal surgery was performed on 15 dogs, with a mucoperiosteal flap affording access for introduction of erythrosine (test) or saline (control) solutions, and subsequent flap replacement. The dogs were sacrificed at 2, 7, 10, 14, 21, and 28 days. Autopsy specimens were prepared, stained, sectioned, and examined by light microscopy. The general amount, degree, and type of inflammatory infiltrate was evaluated and recorded. Erythrosine had no apparent effect on the clinical healing time, alveolar bone, or gingival connective tissue in regard to the general degree, type, and location of the inflammation infiltrate based on postsurgical observations.
Rapley
J W
JW
Department of Periodontics, Wilford Hall USAF Medical Center, Lackland AFB, TX.
Brunsvold
M A
MA
D000539:Alveolar Process / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D004285:Dogs; D004923:Erythrosine / Q000627:therapeutic use*; D005881:Gingiva / Q000187:drug effects* / Q000473:pathology; D005891:Gingivitis / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D010510:Periodontal Diseases / Q000601:surgery*; D010865:Pilot Projects; D010950:Plasma Cells / Q000473:pathology; D013524:Surgical Flaps; D014945:Wound Healing
D004923:Erythrosine