title: A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord.
abstract: During development and following axonal injury in adults, neurons in the anterior horn of the spinal cord express nerve growth factor receptor (NGF-R) messenger ribonucleic acid (mRNA) and protein. To examine whether unlesioned anterior horn neurons show signs of responsiveness to NGF in adult animals, spinal cords from control rats and monkeys, as well as animals that had received NGF intraventricularly, were processed for NGF-R immunocytochemistry using monoclonal and polyclonal antibodies against NGF-R. In all animals, neurons located in central/ventral sectors of lamina IX in lumbar segments of the spinal cord expressed NGF-R-like immunoreactivity; this population of nerve cells appeared to increase in size after treatment with NGF. Our findings suggest that, in adults, a subset of spinal motor neurons may respond to NGF.
authors.affiliation: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2181.
authors.forename: V E
authors.initials: VE
authors.lastname: Koliatsos
authors.forename: D L
authors.initials: DL
authors.lastname: Shelton
authors.forename: W C
authors.initials: WC
authors.lastname: Mobley
authors.forename: D L
authors.initials: DL
authors.lastname: Price
mesh_terms: D000818:Animals; D007158:Immunologic Techniques; D008161:Lumbosacral Region; D008252:Macaca fascicularis; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*
chemical_list: D009414:Nerve Growth Factors; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor