Effect of atrial natriuretic peptide and on atriopeptins on the human isolated bronchus. Comparison with the reactivity of the guinea-pig isolated trachea.
ANF, ANF7-28 and atriopeptins (AP1, AP2 and AP3) (10(-11) to 3 x 10(-7) M) induce a relaxant response on the guinea-pig isolated trachea, which is partially potentiated by the enkephalinase inhibitor thiorphan 10(-5) M but is unmodified by epithelium removal. Conversely, these drugs were found to be without any significant relaxant effect on the isolated human bronchus. Several hypotheses, such as the activation of ANF receptors not located on airway smooth muscle or an indirect effect of ANF in vivo are suggested to explain the discrepancy between these in vitro results and those of clinical trials in asthmatic subjects.
Candenas
M L
ML
Faculté de Médecine Paris-Ouest, Laboratorie de Pharmacologie Respiratorie, France.
Naline
E
E
Puybasset
L
L
Devillier
P
P
Advenier
C
C
D000595:Amino Acid Sequence; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects* / Q000502:physiology; D004357:Drug Synergism; D004848:Epithelium / Q000502:physiology; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D015244:Thiorphan / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor; D015244:Thiorphan