Inhibitory effect of MK-801 (noncompetitive NMDA receptor antagonist) on kindling-induced synaptic potentiation in acutely prepared rabbits.
We investigated effects of a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, on potentiation of field potentials elicited in the dentate gyrus by single shocks to the perforant path after kindling to the pathway in acutely prepared rabbits. MK-801, which was intracortically injected after the establishment of kindling-induced potentiation, remarkably and dose-dependently reduced the potentiation. These results suggest that activated NMDA receptors contribute substantially to the expression of kindling-induced potentiation.
Jibiki
I
I
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Fujimoto
K
K
Kubota
T
T
Yamaguchi
N
N
D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000033:anatomy & histology / Q000187:drug effects; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D011817:Rabbits; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013569:Synapses / Q000187:drug effects*
D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate