title: Endothelin-induced long-lasting mesenteric vasoconstriction: a hypothetical mechanism of non-occlusive intestinal infarction.
abstract: The in vivo mesenteric vascular effect of the novel, endothelium-derived endogenous polypeptide, endothelin-1 (ET-1) was examined in experiments performed on pentobarbital-anesthetized dogs. Blood supply to a segment of the small bowel was measured simultaneously with an electromagnetic flow probe and computer-assisted thermography which senses flow-dependent infrared irradiation. It was found that close mesenteric arterial injections of ET-1 produced long-lasting flow decreases of considerable magnitude: the single dose of 1 nmol reduced blood flow by nearly 90 percent, and even the minimal single amount of 1 pmol produced statistically significant vasoconstriction. The thermographic analysis proved the homogenous character of these reactions. Unlike vascular responses elicited by most of the known vasoconstrictive agents, the ET-1-induced spastic effects were maintained without a continuous exposure (drug infusion). All features that characterize the spastic ET-1 action qualify the peptide for a hypothetical candidate of mediating the nonocclusive mesenteric ischemic syndrome.
authors.affiliation: Department of Cardiovascular Surgery, Semmelweis University Medical School, Budapest, Hungary.
authors.forename: I
authors.initials: I
authors.lastname: Dóbi
authors.forename: V
authors.initials: V
authors.lastname: Kékesi
authors.forename: M
authors.initials: M
authors.lastname: Tóth
authors.forename: S
authors.initials: S
authors.lastname: Juhász-Nagy
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D004285:Dogs; D016232:Endothelins / Q000494:pharmacology / Q000502:physiology*; D005260:Female; D007238:Infarction / Q000503:physiopathology*; D007422:Intestines / Q000098:blood supply*; D008297:Male; D008638:Mesenteric Arteries / Q000503:physiopathology*; D013817:Thermography; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D016232:Endothelins