The life-saving effect of physostigmine in haemorrhagic shock.
The intravenous injection of physostigmine (70 micrograms kg-1) produces a life-saving effect in acute haemorrhagic shock in non-anaesthetized rabbits. This effect is most probably due to a transfer of tissue fluids into circulation. The crucial beneficial effect of physostigmine might be a decrease of the capillary hydrostatic pressure due to changes in pre- to postcapillary resistance ratio. Both lines of defence comprise a normalization of blood pressure and normalization of blood volume, thus saving the life of the animal.
Savić
J
J
Institute for Medical Research, Military Medical Academy, Belgrade, Yugoslavia.
Varagić
V M
VM
Prokić
D
D
Vujnov
S
S
Prostran
M
M
Zunić
G
G
Stanimirović
D
D
Rastovac-Bogdanović
M
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D010830:Physostigmine / Q000627:therapeutic use*; D011817:Rabbits; D012769:Shock / Q000188:drug therapy*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D010830:Physostigmine