title: Mitotic spindle morphogenesis in animal cells.
abstract: Assembly of the mitotic spindle is an interesting example of morphogenesis at the cellular level. The temporal control of this major event involves the periodic activation of the cyclin-cdc2 kinase complex. In this review, I report recent results that have shed some light on the temporal regulation of centrosome duplication, microtubule nucleation and microtubule dynamics. Reorganization of highly dynamic microtubules into a bipolar spindle probably requires kinesin and dynein-like motors and their role is discussed in an hypothetical model that may be applicable to all mitotic spindles.
authors.affiliation: Cell Biology Program, European Molecular Biology Laboratory, Heidelberg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Karsenti
mesh_terms: D000818:Animals; D016203:CDC2 Protein Kinase / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D004398:Dyneins / Q000502:physiology; D016547:Kinesins / Q000502:physiology; D008870:Microtubules / Q000502:physiology; D009024:Morphogenesis; D008941:Spindle Apparatus / Q000502:physiology*
chemical_list: D016213:Cyclins; D016203:CDC2 Protein Kinase; D004398:Dyneins; D016547:Kinesins