Human papillomavirus types 16 and 18 in adenocarcinoma of the uterine cervix.
Many reports have shown a link between human papillomavirus (HPV) and cervical squamous neoplasia. However, the association of HPV with cervical adenocarcinoma has been studied less extensively. The authors evaluated the presence of HPV-DNA in 106 patients with adenocarcinoma of the uterine cervix by in situ hybridization, using 35S-labeled probes for HPV 16 DNA and HPV 18 DNA. The overall prevalence of HPV-DNA was 18% (19 of 106). HPV 16 was present in 2 (2%) cases, HPV 18 was observed in 15 (14%) cases, and both HPV 16 and HPV 18 were found in 2 (2%) cases. There was a correlation between HPV-DNA positivity and tumor stage (P less than 0.01) and tumor size (P less than 0.05), but there was no relationship between HPV-DNA positivity and tumor differentiation, proliferation (S-phase fraction), ploidy, lymph node metastases, or five-year survival rate. These results suggest that HPV 18 DNA is associated with cervical adenocarcinoma but the presence of HPV 18 has no influence on overall survival.
Leminen
A
A
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.
Paavonen
J
J
Vesterinen
E
E
Wahlström
T
T
Rantala
I
I
Lehtinen
M
M
D000230:Adenocarcinoma / Q000235:genetics / Q000382:microbiology* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D011003:Ploidies; D013462:Sulfur Radioisotopes; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000382:microbiology* / Q000473:pathology
D004279:DNA, Viral; D013462:Sulfur Radioisotopes