Immune monitoring after renal transplantation. II. Post-transplant disturbances in the CD3 complex expression may be caused by immunosuppression.
The in vitro effect of major immunosuppressive agents on the CD3-TCR complex expression on T cells was studied. Cyclosporine and azathioprine caused a marked diminution of alpha/beta, but not gamma/delta and CD3 chains detectability. Prednisolone effect was less manifested. Our data suggest that the reported decrease in alpha/beta chains expression on T cells from renal allograft recipients may be caused by post-transplant immunosuppression.
Nowaczyk
M
M
Department of Immunology, Medical School, Warsaw.
Górski
A
A
Małdyk
M
M
Juskowa
J
J
Wyzgal
J
J
Modlińska
M
M
Bukowska
J
J
Morzycka-Michalik
M
M
D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism*; D001379:Azathioprine / Q000494:pharmacology; D017252:CD3 Complex; D016572:Cyclosporine / Q000494:pharmacology; D015536:Down-Regulation; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D016030:Kidney Transplantation / Q000276:immunology*; D011239:Prednisolone / Q000494:pharmacology; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D007166:Immunosuppressive Agents; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016572:Cyclosporine; D011239:Prednisolone; D001379:Azathioprine