[Hepatitis B and primary cancer of the liver: recent data on the role of B virus in oncogenesis].
Although epidemiologic studies have clearly demonstrated the importance of the hepatitis B virus in the genesis of hepatocellular carcinoma, the molecular basis for this tumorigenic effect is still under debate. Studies of woodchucks infected with a virus closely related to the human hepatitis B virus suggest that integration of the viral DNA in the host genome often plays a direct role by activating myc cellular oncogenes through insertional mutagenesis. A similar mechanism involving other cell genes has been found less frequently in human hepatocellular carcinomas. The human hepatitis B virus may contribute to tumorigenesis in a more indirect fashion, by inducing preneoplastic liver lesions which gradually become malignant.
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Unité de Recombinaison et Expression Génétique (INSERM U.163, CNRS URA.217), Institut Pasteur, Paris, France.
D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D009857:Oncogenes / Q000235:genetics
Hépatite B et cancer primitif du foie: données récentes sur le rôle du virus B dans l'oncogenèse.