Prevention of paracetamol-induced hepatotoxicity in the rat by the thromboxane receptor antagonist, Sulotroban (BM 13177).
Horton
A A
AA
School of Biochemistry, University of Birmingham, U.K.
Wood
J M
JM
D000082:Acetaminophen / Q000009:adverse effects*; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D003600:Cytosol / Q000378:metabolism; D004789:Enzyme Activation; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D010741:Phospholipases A / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors*; D017482:Receptors, Thromboxane; D013449:Sulfonamides / Q000627:therapeutic use*; D014343:Trypan Blue / Q000493:pharmacokinetics
D011982:Receptors, Prostaglandin; D017482:Receptors, Thromboxane; D013449:Sulfonamides; D016718:Arachidonic Acid; D000082:Acetaminophen; C040624:sulotroban; D000410:Alanine Transaminase; D010741:Phospholipases A; D014343:Trypan Blue; D002118:Calcium