Hydramycin, a new antitumor antibiotic. Taxonomy, isolation, physico-chemical properties, structure and biological activity.
A new antitumor antibiotic hydramycin was isolated from the fermentation broth of Streptomyces violaceus P950-4 (ATCC 53807). It showed potent antibacterial and cytotoxic activity and increased the survival time of mice inoculated with P388 leukemia. A new structure related to the pluramycin group antibiotics was assigned by its spectroscopic experiments.
Hanada
M
M
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Kaneta
K
K
Nishiyama
Y
Y
Hoshino
Y
Y
Konishi
M
M
Oki
T
T
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy; D004318:Doxycycline; D005260:Female; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D004318:Doxycycline