[Association of atherosclerosis and nephropathy in diabetes mellitus. Role of lipid anomalies].
Atherosclerosis is the main cause of mortality in diabetic patients, and the incidence of coronary heart disease is increased in the presence of microalbuminuria. The mechanisms of this association are not known and could involve genetic factors (predisposition to hypertension), renal disease and dyslipidemia. An increase in plasma triglyceride and apoprotein B levels, a decrease in plasma HDL cholesterol, qualitative abnormalities of VLDL and HDL are related to cardiovascular risk in diabetic patients. All these factors are worsened by nephropathy. Lipoproteins abnormalities could be involved in the progression of renal injury. In microalbuminuric patients, it seems important to reduce glomerular hyperfiltration and to normalize glycemia and blood pressure in order to prevent impairment of renal injury and dyslipidemia induced by nephropathy. Early treatment of lipoprotein abnormalities could decrease the incidence of cardiovascular complications.
Picard
S
S
Service d'Endocrinologie et des Maladies de la Nutrition, INSERM U 197, Hôpital de l'Antiquaille, Lyon.
Borson-Chazot
F
F
Berthezène
F
F
D000419:Albuminuria / Q000150:complications; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001055:Apolipoproteins B / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D008078:Cholesterol, LDL / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D003928:Diabetic Nephropathies / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008075:Lipoproteins, HDL / Q000378:metabolism; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*
D000806:Angiotensin-Converting Enzyme Inhibitors; D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides
Association athérosclérose-néphropathie dans le diabète sucré. Rôle des anomalies lipidiques.