Viral protein cleavages as a drug design target.
Many animal and plant viruses encode proteolytic enzymes which are involved in regulation of viral replication and assembly. The proteases are becoming well-characterized, and offer attractive features for the design of selective antiviral agents. Approaches to the assay of viral protease inhibitors and the various classes identified are described.
Korant
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Central Research and Development Department, Du Pont Company Experimental Station E 328, Wilmington, Delaware 19880-0328.
D015195:Drug Design; D016333:HIV Protease / Q000187:drug effects*; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D014764:Viral Proteins / Q000187:drug effects
D017320:HIV Protease Inhibitors; D014764:Viral Proteins; D016333:HIV Protease