title: Comparative evaluation of blood schizontocidal activity of quinine and quinidine against drug resistant rodent malaria.
abstract: Blood schizontocidal activity of quinine and quinidine has been compared against sensitive as well as chloroquine/mefloquine/quinine resistant strains of Plasmodium berghei and a multiple resistant strain of P. yoelii nigeriensis in Swiss mice. Evaluation of results on ED50/ED90 basis has shown distinct superiority of quinidine over quinine against sensitive as well as drug resistant strain of rodent malaria.
authors.affiliation: Central Drug Research Institute, Lucknow, India.
authors.forename: M
authors.initials: M
authors.lastname: Kazim
authors.forename: S K
authors.initials: SK
authors.lastname: Puri
authors.forename: G P
authors.initials: GP
authors.lastname: Dutta
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D008288:Malaria / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D051379:Mice; D010962:Plasmodium berghei; D010967:Plasmodium yoelii; D011802:Quinidine / Q000008:administration & dosage / Q000627:therapeutic use*; D011803:Quinine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D011803:Quinine; D011802:Quinidine