[Platelets and migraine. Correlation between biochemical markers of platelet aggregation and serotonin].
The correlation between the biochemical markers of platelet activation and serotonin in migraine was investigated. The beta-thromboglobulin (beta-TG), platelet factor 4 (PF-4) and serotonin levels in 105 patients with migraine were measured. The results confirmed an increase in beta-TG and PF4 levels and a reduction in serotonin levels during the migraine attacks. However, we did not find a significant correlation between these fluctuations. These findings suggest the existence of extraplatelet mechanism in the pathophysiology of migraine.
Leira
R
R
Servicio de Neurología, Hospital General de Galicia Clínico Universitario, Santiago de Compostela, La Coruña.
Castillo
J
J
Martínez
F
F
Castro
A
A
Lema
M
M
Noya
M
M
D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D001792:Blood Platelets / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood*; D010974:Platelet Aggregation; D010978:Platelet Factor 4 / Q000032:analysis*; D012701:Serotonin / Q000097:blood / Q000378:metabolism*; D001620:beta-Thromboglobulin / Q000032:analysis*
D015415:Biomarkers; D001620:beta-Thromboglobulin; D012701:Serotonin; D010978:Platelet Factor 4
Plaquetas y migraña. Correlación entre marcadores bioquímicos de agregación plaquetaria y serotonina.