4-Halo-3-hydroxyanthranilates are potent inhibitors of 3-hydroxyanthranilate oxygenase in the rat brain in vitro and in vivo.
Walsh
J L
JL
Maryland Psychiatric Research Center, Baltimore 21228.
Todd
W P
WP
Carpenter
B K
BK
Schwarcz
R
R
D050561:3-Hydroxyanthranilate 3,4-Dioxygenase; D015095:3-Hydroxyanthranilic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D003956:Dialysis; D049308:Dioxygenases; D006624:Hippocampus / Q000201:enzymology; D008297:Male; D010105:Oxygenases / Q000037:antagonists & inhibitors*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D011805:Quinolinic Acids; D015095:3-Hydroxyanthranilic Acid; D010105:Oxygenases; D049308:Dioxygenases; D050561:3-Hydroxyanthranilate 3,4-Dioxygenase; D017378:Quinolinic Acid