Enterolobin induces rat paw oedema independently of PAF-acether.
The potential participation of PAF-acether (PAF) on the paw oedema triggered by enterolobin was investigated. Intraplantar injections of enterolobin (5-20 micrograms/paw) yielded a dose response curve for oedema which appeared after 30 min, peaked in the interval between 2-4 h and faded after 24 h. The pre-treatment with BN 52021, but not with other PAF antagonists such as PCA 4248 or WEB 2086, significantly blocked enterolobin-induced oedema. To clarify better the discrepant results obtained with the PAF antagonists, desensitization to PAF was performed. The oedema triggered by enterolobin was not modified in PAF desensitized animals. It was concluded that the paw inflammation induced by enterolobin does not require PAF mechanism.
Castro-Faria-Neto
H C
HC
Instituto Oswaldo Cruz, Departamento de Fisiologia e Farmacodinâmica, Rio de Janeiro, Brasil.
Cordeiro
R S
RS
Martins
M A
MA
Correia-Da-Silva
A C
AC
Bozza
P T
PT
Sousa
M V
MV
Morhy
L
L
D000818:Animals; D001381:Azepines / Q000494:pharmacology; D004095:Dihydropyridines / Q000494:pharmacology; D004224:Diterpenes; D004487:Edema / Q000139:chemically induced*; D046934:Ginkgolides; D007783:Lactones / Q000494:pharmacology; D008297:Male; D010940:Plant Proteins / Q000037:antagonists & inhibitors / Q000633:toxicity*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014230:Triazoles / Q000494:pharmacology
D001381:Azepines; D004095:Dihydropyridines; D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010940:Plant Proteins; D010972:Platelet Activating Factor; D014230:Triazoles; C052518:WEB 2086; C066024:PCA 4248; C073270:enterolobin protein, Enterolobium contortisiliquum; C045856:ginkgolide B