title: Evidence for a role of phosphofructokinase and tRNA in the polyribosome disaggregation of amino acid deficiency.
abstract: The activity of rabbit muscle phosphofructokinase was inhibited by transfer ribonucleic acid. This inhibition was reduced by inclusion of an amino-acyl-tRNA charging system. The results are discussed in terms of the loss of ATP in amino acid deprived cells and in the critical role of fructose 1,6-diphosphate in peptide chain initiation.
authors.affiliation: Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda, MD.
authors.forename: M
authors.initials: M
authors.lastname: Rabinovitz
mesh_terms: D000596:Amino Acids / Q000378:metabolism* / Q000494:pharmacology; D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism; D000818:Animals; D007700:Kinetics; D009132:Muscles / Q000201:enzymology; D010732:Phosphofructokinase-1 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011132:Polyribosomes / Q000378:metabolism* / Q000648:ultrastructure; D012343:RNA, Transfer / Q000378:metabolism* / Q000494:pharmacology; D011817:Rabbits
chemical_list: D000596:Amino Acids; D012343:RNA, Transfer; D010732:Phosphofructokinase-1; D000604:Amino Acyl-tRNA Synthetases