[Effects of berberine on synthesis of platelet TXA2 and plasma PGI2 in rabbits].
Using radioimmunoassay, we found that berberine (0.50 mol.L-1) inhibited dose-dependently collagen-, ADP-, and arachidonic acid (AA)-induced TXA2 release from platelets. Berberine (25 mg.kg-1) iv lowered rabbit plasma level of PGI2 from 0.92 +/- 0.20 to 0.61 +/- 0.08 ng.ml-1 after 60 min. The results suggest that berberine inhibits AA release from cell membrane phospholipids and its metabolism.
Huang
C G
CG
Department of Biochemistry, Second Military Medical University, Shanghai, China.
Chu
Z L
ZL
Yang
Z M
ZM
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D005260:Female; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013929:Thromboxane B2 / Q000097:blood*
D010975:Platelet Aggregation Inhibitors; D001599:Berberine; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha