[The antiradiation properties of betamide under conditions of sublethal and lethal gamma irradiation].
Bone marrow cellularity in the femur, mass and cellularity of the spleen and small intestine, and nucleic acid concentration in the leukocyte mass of blood were investigated after the intraperitoneal administration of betamide (500 mg/kg) 15 min before gamma irradiation of mice with doses of 4, 7 and 9 Gy. The number of myelokaryocytes and splenocytes in the protected animals was shown to exceed considerably that in the controls on days 3 and 9 after irradiation with the three doses. With betamide injected on day 9 following irradiation the number of nucleated cells of the small intestine was larger and the nucleic acid concentration in leukocytes higher than the same indices in the irradiated control.
Tenchova
V B
VB
Pantev
T P
TP
D000208:Acute Disease; D004999:Amifostine / Q000627:therapeutic use*; D000818:Animals; D004064:Digestive System / Q000187:drug effects / Q000528:radiation effects; D004338:Drug Combinations; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D007962:Leukocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008624:Mercaptoethylamines / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D009696:Nucleic Acids / Q000187:drug effects / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D011837:Radiation-Protective Agents / Q000627:therapeutic use*
D004338:Drug Combinations; D008624:Mercaptoethylamines; D009696:Nucleic Acids; D011837:Radiation-Protective Agents; C002825:WR 2529; D004999:Amifostine
Issledovanie protivoluchevykh svoĭstv betamida v usloviiakh subletal'nogo i letal'nogo gamma-oblucheniia.