title: Synovial T lymphocyte-specific immune response to Chlamydia trachomatis in Reiter's disease.
abstract: We studied the lymphocyte proliferative response to Chlamydia trachomatis in Reiter's syndrome (RS) compared with that in other rheumatic diseases. RS patients showed significantly increased C trachomatis-specific synovial fluid (SF) T cell proliferation. Proliferating cells were found in both CD4+ and CD8+ T cell subsets. The SF lymphocyte proliferative response to C trachomatis in RS was inhibited by anti-class I and class II major histocompatibility complex monoclonal antibodies, while the response to tuberculin purified protein derivative was inhibited only by anti-class II monoclonal antibodies. T cell receptor gamma/delta-bearing T cells were not consistently increased in RS SF compared with peripheral blood, nor did such cells consistently expand upon in vitro culture with C trachomatis. Finally, there was no correlation between the cellular immune response and levels of antibody to C trachomatis antigens. Our results indicate that a specific T cell response to C trachomatis within the joint plays a role in the pathogenesis of RS.
authors.affiliation: Department of Medicine, Guy's Hospital, London, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Sieper
authors.forename: G
authors.initials: G
authors.lastname: Kingsley
authors.forename: A
authors.initials: A
authors.lastname: Palacios-Boix
authors.forename: C
authors.initials: C
authors.lastname: Pitzalis
authors.forename: J
authors.initials: J
authors.lastname: Treharne
authors.forename: R
authors.initials: R
authors.lastname: Hughes
authors.forename: A
authors.initials: A
authors.lastname: Keat
authors.forename: G S
authors.initials: GS
authors.lastname: Panayi
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000502:physiology; D000917:Antibody Formation; D016918:Arthritis, Reactive / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D002453:Cell Cycle; D002455:Cell Division; D002692:Chlamydia trachomatis / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013583:Synovial Membrane / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D006680:HLA Antigens; D011948:Receptors, Antigen, T-Cell; D016692:Receptors, Antigen, T-Cell, gamma-delta