Coating of commercially available materials with a new heparinizable material.
Different commercial materials, such as polyurethane (PU), plasticized PVC (PVC), glass, Gore-tex, and Dacron, were coated with a well-characterized biomaterial (PUPA) based on polyurethane and poly(amido-amine) components. Two different classes of coating were obtained due to the different characteristics of the substrates. In the case of PVC and polyurethane which are soluble in the solvent of the PUPA-coating solution, there was penetration and blending of the coating and underlying materials. In the case of glass, Gore-tex, and Dacron, which are insoluble in the solvent of the coating solution, only a superficial layer of PUPA could be obtained. The coating stability was investigated and the interaction between coating and underlying material studied by FT-IR. All the stable coatings showed the ability to bind as much heparin as PUPA material by itself.
Barbucci
R
R
C.R.I.S.M.A., Centro Didattico dell'Università, Nuovo Policlinico, Le Scotte, Italy.
Albanese
A
A
Magnani
A
A
Tempesti
F
F
D000327:Adsorption; D001672:Biocompatible Materials; D005898:Glass; D006493:Heparin; D015394:Molecular Structure; D011073:Polyamines; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D011140:Polyurethanes; D011143:Polyvinyl Chloride; D013055:Spectrophotometry, Infrared; D013499:Surface Properties; D013918:Thrombin Time
D001672:Biocompatible Materials; D011073:Polyamines; D011093:Polyethylene Terephthalates; D011140:Polyurethanes; C074348:N2LL poly(amido-amine)-polyurethane copolymer; D011138:Polytetrafluoroethylene; D011143:Polyvinyl Chloride; D006493:Heparin