[Neutrophil chemotactic activity after administration of aspirin during aspirin tolerance in patients with asthma and aspirin hypersensitivity].
The increase of neutrophil chemotactic activity (NCA) is related to degranulation of mast cells. In aspirin asthma following aspirin bronchial provocation NCA increases in 50% to 100% of the studied patients. The authors studied NCA after aspirin in patients with aspirin asthma during a state of induced tolerance. If NCA would not increase that would imply that in the state of induced tolerance degranulation of mast cells does not occur. Out of 22 subjects NCA was increased in 11. In these patients tolerance to aspirin was induced and NCA was once more studied. The authors found that in these patients after a dose of 600 mg of aspirin NCA was not increased. This could impose that in patients with aspirin asthma that developed tolerance to aspirin degranulation of mast cells does not occur.
Szmidt
M
M
Kliniki Pneumonologii i Alergologii IMW AM, Lodzi.
Grzelewska-Rzymowska
I
I
Rozniecki
J
J
Grzegorczyk
J
J
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage*; D001249:Asthma / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000276:immunology / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D002634:Chemotaxis, Leukocyte / Q000187:drug effects / Q000502:physiology*; D004342:Drug Hypersensitivity / Q000276:immunology / Q000503:physiopathology*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology
D001241:Aspirin
Aktywność chemotaktyczna surowicy krwi dla granulocytów obojetnochłonnych po aspirynie w stanie tolerancji na aspiryne u chorych na astme z nadwrazliwościa na te substancje.