title: [Spectrum and territorial distribution of hereditary diseases in the population of the Krasnodar Krai].
abstract: The analysis of the spectrum of hereditary diseases in the population of the Krasnodar province is performed and the influence of the population dynamics factors on the spectrum is discussed. More than 130 nosological forms were discovered in the population of approx. 200,000. Among these, there are 63 autosomal dominant, 49 autosomal recessive and 17 X-linked recessive forms. Of the most frequent autosomal dominant diseases (more than 1 per 50,000) autosomal recessive and X-linked recessive disorders 13, 7 and 7 forms, respectively, were picked up. The coefficient of diversity of hereditary diseases (the number of nosological forms per 10 inhabitants) with different types of inheritance is higher in the Krasnodar population, as compared with the Kostroma population. The problem of similarity of the "nucleus" of autosomal-recessive disorders in Russian populations is discussed.
authors.forename: A N
authors.initials: AN
authors.lastname: Petrin
authors.forename: E K
authors.initials: EK
authors.lastname: Ginter
authors.forename: V A
authors.initials: VA
authors.lastname: Galkina
authors.forename: V I
authors.initials: VI
authors.lastname: Golubtsov
authors.forename: M V
authors.initials: MV
authors.lastname: Khisamova
authors.forename: L K
authors.initials: LK
authors.lastname: Mikhaĭlova
authors.forename: O V
authors.initials: OV
authors.lastname: Khlevnikova
authors.forename: V V
authors.initials: VV
authors.lastname: Polishchuk
authors.forename: G I
authors.initials: GI
authors.lastname: Sukolin
mesh_terms: D005799:Genes, Dominant / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics; D030342:Genetic Diseases, Inborn / Q000453:epidemiology / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D012426:Russia / Q000453:epidemiology; D014960:X Chromosome
vernacular_title: Spektr i territorial'noe rasprostranenie nasledstvennykh bolezneĭ v populiatsiiakh Krasnodarskogo Kraia.