The beta-adrenergic signaling pathway in the heart.
Postsynaptic defects in this important pathway for regulating heart rate and contractile force may contribute to the etiology and pathogenesis of congestive cardiac failure. Such defects may involve the beta-adrenergic receptor, its associated G protein, or adenylate cyclase. Current knowledge about these components of transmembrane cardiac signaling is reviewed.
Homcy
C J
CJ
Harvard Medical School, Boston.
D000262:Adenylyl Cyclases / Q000502:physiology; D003327:Coronary Disease / Q000209:etiology / Q000503:physiopathology; D000242:Cyclic AMP / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases