title: Simultaneous administration of HB recombinant vaccine with diphtheria and tetanus toxoid and oral polio vaccine: a pilot study.
abstract: An extensive vaccination program to be used in highly endemic areas is the main strategy against the spreading of hepatitis B. The purpose of this study was the evaluation of the immune response to the recombinant HB vaccine administered singly or at the same time as other compulsory vaccines anti-diphtheria, anti-tetanus and oral anti-polio. Evidence was found of the serological efficacy both of HB vaccine and compulsory vaccines with a percentage of seroconversion of 100%. However, the infants who received HB vaccine at birth and at the age of 1 month had titers of antiHBs higher than the infants who received HB vaccine at birth and at 3 months. No difference in antibody levels of compulsory vaccines was observed among the study groups and the controls who received only compulsory vaccines. Our results suggest that HB vaccination must be encouraged and pursued in all newborns.
authors.affiliation: Department of Pediatrics, University of Catania, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Barone
authors.forename: L
authors.initials: L
authors.lastname: Mauro
authors.forename: S
authors.initials: S
authors.lastname: Leonardi
authors.forename: M
authors.initials: M
authors.lastname: Ienna
authors.forename: G
authors.initials: G
authors.lastname: Giammanco Bilancia
authors.forename: E
authors.initials: E
authors.lastname: Falcidia
authors.forename: S
authors.initials: S
authors.lastname: Musumeci
mesh_terms: D004168:Diphtheria Toxoid / Q000008:administration & dosage* / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood*; D017325:Hepatitis B Vaccines; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010865:Pilot Projects; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage* / Q000276:immunology; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000276:immunology; D013997:Time Factors; D014614:Vaccines, Synthetic / Q000008:administration & dosage* / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D004168:Diphtheria Toxoid; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D011055:Poliovirus Vaccine, Oral; D013745:Tetanus Toxoid; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines