[Healing promoting effect of azuletil sodium (KT1-32) on experimental chronic gastric ulcers and acceleration of healing in SPF environment].
We examined the healing promoting effects of azuletil sodium on acetic acid and clamping cortisone-induced gastric ulcer in rats. For the experiments on clamping-cortisone gastric ulcer, we used not only conventional rats in conventional conditions but also specific pathogen free (SPF) rats on SPF environment in order to prevent infection. The following results were obtained. 1) In acetic acid ulcer, azuletil sodium (AZE) (greater than or equal to 90 mg/kg/day, p.o.) significantly decreased ulcer index. As estimated on the basis of stage analysis (Ulcer, Healing, Scar), AZE (greater than or equal to 30 mg/kg/day, p.o.) significantly promoted the healing of ulcers. 2) In clamping cortisone ulcer (conventional), AZE (100 mg/kg/day, p.o.) significantly promoted the regeneration of blood vessels. 3) In clamping cortisone ulcer (SPF), AZE at greater than or equal to 30 mg/kg/day and 100 mg/kg/day significantly increased the healing index and mucosal regeneration index, respectively. 4) In clamping cortisone ulcer (SPF), the infection that was observed in the conventional test was not seen at all and the acceleration of healing was observed. Furthermore, the extent of adhesion was also reduced, and the standard errors of various healing indices were smaller. From these results, it is concluded that AZE accelerated the healing of experimentally-induced gastric ulcers in rats.
Wakabayashi
S
S
Research Laboratories, Kotobuki Seiyaku Co., Ltd., Nagano, Japan.
Mochizuki
S
S
Kosakai
K
K
Sekiguchi
H
H
Matsumoto
M
M
Tomiyama
A
A
Takeuchi
M
M
Takeuchi
K
K
Okabe
S
S
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D052176:Azulenes; D002908:Chronic Disease; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000627:therapeutic use*; D013047:Specific Pathogen-Free Organisms; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology
D000897:Anti-Ulcer Agents; D052176:Azulenes; D012717:Sesquiterpenes; C061956:azuletil