Hydrocortisone sensitivity. An investigation into the nature of the allergen.
11 patients, positive to tixocortol pivalate on patch testing, were tested intradermally with a variety of hydrocortisone analogues. Substitution at the C21 position had no effect on the occurrence of positive reactions to hydrocortisone, whereas alteration of any of the carbon rings significantly reduced the number of positive reactions. We suggest that the C17 side chain is involved in protein binding and subsequent presentation of antigenic sites on the carbon rings.
Wilkinson
S M
SM
Department of Dermatology, North Staffordshire Hospital Centre, Hartshill, Stoke-on-Trent, UK.
English
J S
JS
D000287:Administration, Topical; D000485:Allergens; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D003429:Cross Reactions / Q000276:immunology; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects* / Q000031:analogs & derivatives; D007271:Injections, Intradermal; D010328:Patch Tests
D000485:Allergens; D000893:Anti-Inflammatory Agents; C019112:tixocortol pivalate; D006854:Hydrocortisone