title: Antimalarial chemotherapy with natural products and chemically defined molecules.
abstract: In the present work we have described the in vivo antimalarial activity of six different plants. Two of them (Vernonia brasiliana and Eupatorium squalidum) were tested in a randomic approach among 273 crude extracts from plants; four (Acanthospermum australe, Esenbeckia febrifuga, Lisianthus speciosus and Tachia guianensis) were selected after screening 22 crude extracts from different medicinal plants used in Brazil against fever and/or malaria. We also studied chemically defined molecules and some of them showed antimalarial activity in vitro. Some aspects of recent research with natural products aiming to produce drugs are discussed.
authors.affiliation: Departamento de Parasitologia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brasil.
authors.forename: L H
authors.initials: LH
authors.lastname: Carvalho
authors.forename: A U
authors.initials: AU
authors.lastname: Krettli
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D001938:Brazil; D004353:Drug Evaluation, Preclinical; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D010962:Plasmodium berghei / Q000187:drug effects / Q000254:growth & development
chemical_list: D000962:Antimalarials; D010936:Plant Extracts