title: Quantitative relationships between left ventricular ejection and wall thickening and geometry.
abstract: The quantitative relationships that exist between left ventricular (LV) wall shortening, wall thickening, and geometry during LV ejection are not well defined. We used a mathematical model to measure these parameters in 40 patients with various LV geometries studied by echocardiography. As opposed to wall shortening, the percent contribution of wall thickening to LV ejection (% delta Vh) was 25 +/- 2% in normal subjects; in all the patients, it varied from 18 to 45% and was inversely correlated (r = 0.94) to the midwall radius-to-wall thickness ratio (R/h) of the ventricle at end diastole. On the other hand, the ratio of the quantity of blood ejected per unit of LV wall volume magnitude of delta V/V omega magnitude of varied from 0.20 to 1.20 (normal subjects 0.83 +/- 0.11) and was directly correlated (r = 0.94) to R/h; using independent data in the literature, we also found a similar relationship (r = 0.80) between the ratio of quantity of blood ejected per unit of LV mass (magnitude of delta V/M omega magnitude of) and R/h. Patients with presumably abnormal myocardial function did not satisfy the relationship between magnitude of delta V/V omega magnitude of or magnitude of delta V/M omega magnitude of and R/h.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Quebec Heart Institute, Laval University, Sainte-Foy, Canada.
authors.forename: J G
authors.initials: JG
authors.lastname: Dumesnil
authors.forename: R M
authors.initials: RM
authors.lastname: Shoucri
mesh_terms: D001022:Aortic Valve Insufficiency / Q000473:pathology / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000473:pathology / Q000503:physiopathology; D006332:Cardiomegaly / Q000473:pathology / Q000503:physiopathology; D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000503:physiopathology; D006321:Heart / Q000033:anatomy & histology* / Q000502:physiology; D006352:Heart Ventricles / Q000033:anatomy & histology; D006801:Humans; D008955:Models, Cardiovascular; D013318:Stroke Volume / Q000502:physiology; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*