Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14.
This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcr alpha, and Myhc alpha loci.
Traystman
M D
MD
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-6495.
Chow
L H
LH
McManus
B M
BM
Herskowitz
A
A
Nesbitt
M N
MN
Beisel
K W
KW
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics; D002874:Chromosome Mapping; D002908:Chronic Disease; D003384:Coxsackievirus Infections / Q000235:genetics; D029822:Enterovirus B, Human; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D051379:Mice; D008815:Mice, Inbred Strains; D009205:Myocarditis / Q000235:genetics / Q000382:microbiology*; D010641:Phenotype