Effect of the third-strand length on the formation of DNA triple helix.
The triple-helix formation of octadeoxyribonucleotides, (dA)8 and (dT)8, and a shorter oligonucleotide, (dT)n (n; 4, 5, 6, or 7) has been studied by UV and CD measurements. The results showed that the third strand, (dT)5, (dT)6, or (dT)7 can bind to the double helix of (dA)8.(dT)8 at 50 mmol dm-3 MgCl2 though (dT)4 can not bind at the same concentration of the salt.
Sugimoto
N
N
Department of Chemistry, Faculty of Science, Konan University, Kobe, Japan.
Shintani
Y
Y
Sasaki
M
M
D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation
D004247:DNA