Resistance of viruses to antiviral drugs.
In recent years, substantial advances in antiviral therapy have been made; however, in the immunocompromised host, antiviral drug resistance is becoming an issue of increasing clinical importance. Understanding the mechanism of action of antiviral agents, especially those used to treat herpesvirus infections, may enable us to design new therapeutic agents and better treatment regimens to deal with antiviral drug resistance.
Freifeld
A G
AG
Medical Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Ostrove
J M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000998:Antiviral Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D006566:Herpesviridae Infections / Q000188:drug therapy* / Q000209:etiology; D006801:Humans
D000998:Antiviral Agents