Potentiation of renal tumorigenicity by cyclosporine A in streptozotocin diabetic rats.
Male Wistar rats with streptozotocin induced diabetes were treated every third day with 10 mg/kg (13 rats) of cyclosporine A (CyA) for 20 weeks. At sacrifice, 7 of 13 rats (53.8%) demonstrated renal tumors. By contrast, only 2 of 16 streptozotocin diabetic rats (12.5%) without CyA demonstrated renal tumors. No tumors were noted in 10 non-diabetic control rats. These studies suggest that CyA potentiates renal tumorigenicity in streptozotocin diabetic rats.
Reddi
A S
AS
Department of Medicine, UMDNJ-New Jersey Medical School, Newark 07103-2757.
Jyothirmayi
G N
GN
Halka
K
K
Khan
M Y
MY
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003524:Cyclosporins / Q000633:toxicity*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D004357:Drug Synergism; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013311:Streptozocin / Q000633:toxicity*
D003524:Cyclosporins; D013311:Streptozocin