title: Clinical manifestations of primary herpes simplex virus type 1 infection in a closed community.
abstract: The clinical features and the molecular epidemiology of primary herpes simplex virus type 1 (HSV-1) infection among children younger than 3 years of age were investigated in day-care nursery. Serial sera were assayed for anti-HSV-1 glycoprotein B antibody by enzyme-linked immunosorbent assay. Serologic examinations revealed 55 cases of primary HSV infection during the observation period. Fifty-one of them (93%) had typical herpetic gingivostomatitis, showing a high rate of clinically overt infection. Four outbreaks of herpetic gingivostomatitis were observed during the observation period. Forty-one children were infected with HSV-1 in the outbreaks. The rates of infection in the susceptible children were 81%, 73%, 78%, and 100%, respectively, in the four outbreaks. Restriction endonuclease analysis of DNA of isolated HSV revealed that only one strain of HSV-1 had been transmitted among children for a long period.
authors.affiliation: Department of Pediatrics, Nagoya University, School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kuzushima
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Kino
authors.forename: S
authors.initials: S
authors.lastname: Kido
authors.forename: N
authors.initials: N
authors.lastname: Hanada
authors.forename: M
authors.initials: M
authors.lastname: Shibata
authors.forename: T
authors.initials: T
authors.lastname: Morishima
mesh_terms: D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis; D002656:Child Day Care Centers; D002675:Child, Preschool; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018139:Simplexvirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D013283:Stomatitis, Herpetic / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission; D014759:Viral Envelope Proteins / Q000276:immunology; D014771:Virion / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus; D004262:DNA Restriction Enzymes