The activity of alpha-amylase and gamma-amylase in serum and pancreatic homogenate of rats with experimental liver damage treated with colchicine.
In connection with extending the therapeutic application of colchicine to include its use in the treatment of liver fibrosis in cirrhosis and possible harmful effects of this drug on other organs, the pancreas in particular, the authors studied this problem experimentally. For this purpose a model of experimental cirrhosis in rats produced with chronic administration of carbon tetrachloride was used, and in the third and ninth months of the experiment the activity of alpha-amylase and gamma-amylase was determined in the serum and pancreatic homogenate. The results did not show any unfavourable effect of colchicine administered in their therapeutic doses for long time periods on the pancreas in experimental rats and in healthy controls.
Simon
K
K
Department of Infectious Diseases, Medical Academy in Wrocław.
Gładysz
A
A
Bakońska-Pacoń
E
E
Sobiech
K A
KA
Dzik
T
T
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000201:enzymology*; D003078:Colchicine / Q000494:pharmacology*; D005260:Female; D005087:Glucan 1,4-alpha-Glucosidase / Q000097:blood*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D011915:Rats, Inbred BUF; D000516:alpha-Amylases / Q000097:blood*
D000516:alpha-Amylases; D005087:Glucan 1,4-alpha-Glucosidase; D003078:Colchicine