Oxygen radicals and neuropsychiatric illness. Some speculations.
Free radicals are reactive chemical species with an unpaired electron that are produced through a variety of physiologic and pathologic processes. Free radicals have been implicated in a variety of neuropsychiatric conditions, many of which are marked by the gradual development of psychopathologic symptoms and movement disorder. There is evidence that radical-induced damage may be important in Parkinson's disease, tardive dyskinesia, metal intoxication syndromes, and Down's syndrome, and possibly also in schizophrenia, Huntington's disease, and Alzheimer's disease. Although some of this evidence is highly speculative, it may offer an avenue for further understanding and treatment of these conditions.
Lohr
J B
JB
Department of Psychiatry, San Diego Veterans Affairs Medical Center, CA 92161.
D000544:Alzheimer Disease / Q000209:etiology; D001927:Brain Diseases / Q000209:etiology; D004314:Down Syndrome / Q000209:etiology; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D005609:Free Radicals / Q000009:adverse effects*; D006801:Humans; D006816:Huntington Disease / Q000209:etiology; D001523:Mental Disorders / Q000209:etiology*; D008670:Metals / Q000506:poisoning; D009422:Nervous System Diseases / Q000209:etiology*; D010300:Parkinson Disease / Q000209:etiology; D017382:Reactive Oxygen Species / Q000009:adverse effects; D012559:Schizophrenia / Q000209:etiology
D005609:Free Radicals; D008670:Metals; D017382:Reactive Oxygen Species