title: [Detection of hepatitis C virus antibody in non-A non-B liver diseases].
abstract: Hepatitis C virus antibody (anti-HCV) was assessed in serum samples from patients with non-A, non-B liver diseases using an Ortho HCV ELISA kit. In patients with posttransfusion hepatitis, anti-HCV was found in 89% and the interval between onset and anti-HCV seroconversion was 51 to 168 (mean 80) days. Anti-HCV remained positive with fluctuating serum GPT levels in 88% of the patients in whom anti-HCV seroconversion was observed. In chronic liver diseases, anti-HCV was found in 70 to 100%, being more common in patients who had a history of blood transfusion. The average interval between transfusion and detectable anti-HCV was 21.5 years. Anti-HCV was also found occasionally in patients having normalized serum GPT level after the onset, HBV carrier with posttransfusion hepatitis and patients with autoimmune hepatitis. Decreasing anti-HCV titer was noted with the normalization of serum GPT levels in the patients who received interferon therapy. These findings suggest that anti-HCV is closely associated with blood transfusion and HCV infection plays an important role in non-A, non-B liver diseases. The improvement of the current HCV assay system seems to contribute to further evaluation of the clinical entity of HCV infection.
authors.affiliation: 1st Department of Internal Medicine, Iwate Medical University, Morioka.
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Chiba
authors.forename: S
authors.initials: S
authors.lastname: Sato
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000032:analysis*; D006526:Hepatitis C / Q000276:immunology* / Q000635:transmission; D006801:Humans; D008297:Male; D008875:Middle Aged; D065227:Transfusion Reaction
chemical_list: D006508:Hepatitis Antibodies