[Two routes chemotherapy by CDDP and STS against liver tumor].
Nine (eight males, one female) patients with unresectable liver tumor (seven HCC and two metastasis) were treated by two-routes chemotherapy using cis-diamminedichloroplatinum (CDDP) and sodium thiosulfate (STS). In these patients, 50-100 mg/body of CDDP was administered through the proper hepatic artery or right hepatic artery by one shot infusion or the balloon-occluded arterial infusion (BOAI) at 10 mg/min, and during administration, intra-inferior vena cava injection of STS (4 g/body) was given. None of 9 patients suffered nausea and vomiting during the treatment, 3 of 9 patients suffered nausea and vomiting to a mild degree after the treatment, none of 9 patients showed significant side effects, such as bone marrow suppression and/or renal disfunction. In conclusion, this study demonstrated the protection effect of STS injected in inferior vena cava against the toxicity of CDDP were well indicated.
Takada
K
K
Department of Radiology, Osaka City University Hospital, Japan.
Takashima
S
S
Nakamura
K
K
Morimoto
A
A
Inoue
A M
AM
Fujimoto
K
K
Murata
K
K
Usuki
N
N
Minakuchi
K
K
Onoyama
Y
Y
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000188:drug therapy*; D002404:Catheterization; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods; D007275:Injections, Intravenous; D008113:Liver Neoplasms / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control; D013885:Thiosulfates / Q000008:administration & dosage* / Q000627:therapeutic use; D014682:Vena Cava, Inferior; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control
D013885:Thiosulfates; C017717:sodium thiosulfate; D002945:Cisplatin