The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene.
The murine GABAA/benzodiazepine (GABAA/BZ) receptor alpha 1 subunit cDNA has been isolated from a BALB/c mouse brain library and sequenced. The cDNA is 2665 nucleotides long with an open reading frame of 455 amino acids. It shows significant homology to the GABAA receptor alpha 1 subunit cDNA sequences of other species. Excluding deletions, the murine GABAA alpha 1 receptor exhibits 96% nucleotide and 100% amino acid sequence homology to the rat alpha 1 receptor cDNA and over 91% nucleotide and 98% amino acid sequence homology to the bovine and human alpha 1 receptor cDNAs in the protein coding region. This murine cDNA was used to locate the alpha 1 receptor subunit gene, Gabra-1, to murine Chromosome 11 between Il-3 and Rel. This assignment extends proximally the segment of mouse Chromosome 11 with known homology to human chromosome 5.
Keir
W J
WJ
Department of Pharmacology, Alcohol Research Center, University of Colorado Health Sciences Center, Denver.
Kozak
C A
CA
Chakraborti
A
A
Deitrich
R A
RA
Sikela
J M
JM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001569:Benzodiazepines / Q000378:metabolism; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011963:Receptors, GABA-A / Q000235:genetics* / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid
D011963:Receptors, GABA-A; D001569:Benzodiazepines