Anti-CD3- or PHA-induced cytotoxicity in human intraepithelial and lamina propria lymphocytes.
Morphological data in humans and rodents and functional data of intraepithelial lymphocytes of mice support the idea that cytotoxic cells are a significant population of the human mucosa. Previously it was shown that human IEL have no spontaneous cell-mediated cytotoxicity and that human LPL cells have anti-CD3-mediated cytotoxicity. We confirm that most individuals have anti-CD3- or PHA-mediated cytotoxicity of LPL. In IEL we do not find cytotoxic function in short-term assays. There is no difference between patients with colon cancer and inflammatory bowel disease.
Rüthlein
J
J
Medizinische Universitätsklinik, Immunologisches Labor, Würzburg, BRD.
Heinze
G
G
D000328:Adult; D000368:Aged; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D003602:Cytotoxicity, Immunologic; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000276:immunology; D011948:Receptors, Antigen, T-Cell; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D010835:Phytohemagglutinins; D011948:Receptors, Antigen, T-Cell