Dopamine receptors in the rat thymus.
Radioreceptor assay and autoradiographic techniques with 3H-SCH 23390 as a ligand were used to characterize pharmacologically and to localize anatomically dopamine D-1 receptor sites in sections of rat thymus. 3H-SCH 23390 was specifically bound to sections of rat thymus in a manner consistent with the labeling of D-1 receptor sites. Autoradiography demonstrated the accumulation of 3H-SCH 23390 binding sites in the cortex of the thymus rather than in corpuscles.
Ricci
A
A
Department of Cardiovascular and Respiratory Sciences, La Sapienza University, Rome, Italy.
Zaccheo
D
D
Amenta
F
F
D000818:Animals; D001345:Autoradiography; D001552:Benzazepines / Q000493:pharmacokinetics; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*; D017447:Receptors, Dopamine D1; D013950:Thymus Gland / Q000294:innervation*
D001552:Benzazepines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1