title: [Serum cationic trypsinogen: marker of exocrine pancreatic dysfunction in children with protein-calorie malnutrition].
abstract: Serum cationic trypsinogen, a non invasive, sensitive test to evaluate the exocrine pancreatic function was measured by radioimmunoassay in 31 children with different degrees of protein-calorie malnutrition (mild, moderate, severe) in whom mean serum albumin values were 3.7 +/- 0.7 g%; 3.1 +/- 0.9 g%; 2.3 +/- 0.4 g%, respectively and in a control group of 20 well-nourished children with mean serum albumin values of 3.9 +/- 0.7 g%. Mean serum trypsinogen levels were significantly elevated in children with malnutrition (mild: 28.5 +/- 2.4 ng/ml, moderate: 31.86 +/- 3.4 ng/ml, and severe: 36.52 +/- 7.8 ng/ml) compared with the mean values in the control group (17.7 +/- 2 ng/ml). (p < 0.001). We conclude that our results suggest evidence of a pancreatic damage in malnourished children and this disfunction increases according to the degree of malnutrition, allowing to be detected with this simple test even when the patient does not present qualitative steatorrhea.
authors.affiliation: Departamento de Pediatría, Hospital Central, Valencia.
authors.forename: C C
authors.initials: CC
authors.lastname: de Kolster
authors.forename: J G
authors.initials: JG
authors.lastname: Kolster
authors.forename: I
authors.initials: I
authors.lastname: Rached
authors.forename: M
authors.initials: M
authors.lastname: Estopiñán
authors.forename: M
authors.initials: M
authors.lastname: Azuaje
authors.forename: G
authors.initials: G
authors.lastname: Bordones
authors.forename: J
authors.initials: J
authors.lastname: Castro
authors.forename: A
authors.initials: A
authors.lastname: Carvajal
authors.forename: N
authors.initials: N
authors.lastname: Laurentin
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010179:Pancreas / Q000503:physiopathology; D010182:Pancreatic Diseases / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D011502:Protein-Energy Malnutrition / Q000097:blood* / Q000150:complications; D011863:Radioimmunoassay / Q000379:methods; D014362:Trypsinogen / Q000097:blood*
chemical_list: D014362:Trypsinogen
vernacular_title: Tripsinógeno catiónico sérico: indicador de disfunción pancreática exocrina en niños con malnutrición proteíno-calórica.