title: Ibuprofen provides longer lasting analgesia than fentanyl after laparoscopic surgery.
abstract: The authors compared the analgesic efficacy of one dose of oral ibuprofen with that of intravenously administered fentanyl for relief of pain after outpatient laparoscopic surgery. Thirty healthy female patients received either 800 mg of oral ibuprofen preoperatively or 75 micrograms of intravenous fentanyl intraoperatively plus respective intravenous or oral placebos in a randomized, double-blind manner. Patients recorded their degree of pain and nausea in the recovery room, in the same-day surgery stepdown unit, during the ride home, and upon arrival at home. The postanesthesia care nurse recorded the amount of fentanyl and droperidol needed to treat pain and nausea in the recovery room. Patients who received ibuprofen were more comfortable in the stepdown unit (P less than 0.05) and after arrival home (P less than 0.05) than those in the fentanyl group. Additionally, patients who received ibuprofen had lower nausea scores in the step-down unit (P less than 0.05); this may have been related to the lower total fentanyl dose in these patients. The authors conclude that ibuprofen may be a useful alternative to fentanyl for providing postoperative analgesia for outpatient surgery.
authors.affiliation: Department of Anesthesiology, University of Connecticut School of Medicine, Farmington 06032.
authors.forename: M
authors.initials: M
authors.lastname: Rosenblum
authors.forename: R S
authors.initials: RS
authors.lastname: Weller
authors.forename: P L
authors.initials: PL
authors.lastname: Conard
authors.forename: E A
authors.initials: EA
authors.lastname: Falvey
authors.forename: J B
authors.initials: JB
authors.lastname: Gross
mesh_terms: D000284:Administration, Oral; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D007275:Injections, Intravenous; D010535:Laparoscopy / Q000009:adverse effects*; D016018:Least-Squares Analysis; D009325:Nausea / Q000139:chemically induced; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D014839:Vomiting / Q000139:chemically induced
chemical_list: D005283:Fentanyl; D007052:Ibuprofen