title: [Captopril-renal function scintigraphy in the clarification of arterial hypertension].
abstract: Renal artery stenosis (RAS) is a rare cause of hypertension. Radiological tests can disclose the morphological changes, but not their functional effect on renal function and perfusion. Normalization of the blood pressure can be achieved by intervention (operation, percutaneous transluminal renal angiography; PTRA), in cases of prolonged RAS-induced hypertension long-term preservation of the organ function is most important. The purpose of this study was the validation of captopril renography as a screening test for hypertension secondary to RAS prior to PTRA. Captopril renography with 99mTc-MAG 3 has a high sensitivity (94%) and acceptable specificity (88%) for the screening of hypertensive patients. The positive predictive value is 74% and the negative predictive value 98%, compared with the "gold standard" of angiography.
authors.affiliation: Abteilung Nuklearmedizin, Radiologische Universitätsklinik, Albert-Ludwigs-Universität, Freiburg.
authors.forename: E
authors.initials: E
authors.lastname: Nitzsche
authors.forename: G
authors.initials: G
authors.lastname: Grosser
authors.forename: C
authors.initials: C
authors.lastname: Rump
authors.forename: E
authors.initials: E
authors.lastname: Strauss
authors.forename: E
authors.initials: E
authors.lastname: Meyer
authors.forename: E
authors.initials: E
authors.lastname: Keller
authors.forename: E
authors.initials: E
authors.lastname: Moser
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002216:Captopril; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides; D015609:Organotechnetium Compounds; D011446:Prospective Studies; D011866:Radioisotope Renography / Q000379:methods*; D017263:Technetium Tc 99m Mertiatide
chemical_list: D009842:Oligopeptides; D015609:Organotechnetium Compounds; D017263:Technetium Tc 99m Mertiatide; D002216:Captopril
vernacular_title: Captopril-Nierenfunktionsszintigraphie (C-NFSZ) bei der Abklärung der arteriellen Hypertonie.