Cisplatin and etoposide combination therapy for primary glial tumors: preliminary results.
In this preliminary trial we studied 29 patients with primary malignant glial tumors to investigate the effectiveness of cisplatin combined with etoposide on these tumors. Hyperfractionated radiation therapy was given in the course of chemotherapy. The time to tumor progression in these glioblastoma multiforme (GBM) patients encouraged us to continue this treatment in a phase III study.
Boiardi
A
A
Istituto Nazionale Neurologico C. Besta, Milano.
Silvani
A
A
Milanesi
I
I
Munari
L
L
Solero
C L
CL
Botturi
M
M
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001254:Astrocytoma / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000188:drug therapy*; D002330:Carmustine / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000188:drug therapy*; D005910:Glioma / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D008875:Middle Aged
D005047:Etoposide; D002945:Cisplatin; D002330:Carmustine