[Application of a slow release system of anti-cancer drug retained in calcium hydroxyapatite ceramic against experimental bone and soft tissue sarcoma].
Cis-platinum enclosed into porous calcium hydroxyapatite ceramics (CDDP-CHA) has already been reported to be an excellent slow releasing drug preparation in vivo and in vitro study. In this paper, CDDP-CHA tried to apply for experimental bone and soft tissue sarcoma. When CDDP-CHA were implanted into solid tumors (Dunn osteosarcoma cells) transplanted subcutaneously in mice, high concentration of CDDP was found and a prolonged retention of the drug in the tumor as same pattern as in normal muscle. In contrast, CDDP concentration in other organs such as liver, kidney were significantly lower than in the tumor. Tumor growth was markedly inhibited at 30 days after CDDP-CHA implantation into the tumor compared to that after intraperitoneal administration. CDDP-CHA showed a similar effect to experimental bone tumor (mammary carcinoma) as that of soft tissue tumor. These result suggests that this delivery system will be able to apply clinically for bone and soft tissue sarcoma.
Shinto
Y
Y
Dept. of Orthopaedic Surgery, Osaka University Medical School.
Uchida
A
A
Araki
N
N
Ono
K
K
D000818:Animals; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D017886:Durapatite; D005260:Female; D006882:Hydroxyapatites / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007274:Injections, Intraperitoneal; D051379:Mice; D008809:Mice, Inbred C3H; D051381:Rats; D011919:Rats, Inbred Strains; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D003692:Delayed-Action Preparations; D006882:Hydroxyapatites; D017886:Durapatite; D002945:Cisplatin