Effect of mannitol on intracranial pressure in focal cerebral ischemia. An experimental study in a rat.
The authors studied the effects of mannitol on intracranial pressure (ICP) in experimental focal ischemia in a rat. Stroke was produced by occlusion of middle cerebral artery (MCA). The study revealed that mannitol decreases ICP in ischemic stroke much less then in healthy animals and also a significant rebound effect was seen, especially in the 5th and 7th day after MCA occlusion. The authors suggest a very limited use of mannitol in clinical treatment of elevated ICP after cerebral ischemic stroke.
Kotwica
Z
Z
Department of Neurosurgery, Medical Academy, Lódź, Poland.
Persson
L
L
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D002537:Intracranial Arteriosclerosis / Q000188:drug therapy / Q000503:physiopathology; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D008353:Mannitol / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
D008353:Mannitol