Similar effects of treatment with desipramine and electroconvulsive shock on 5-hydroxytryptamine1A receptors in rat brain.
The effect of chronic and acute treatment with desipramine (DMI) and electroconvulsive shock (ECS) on 5-hydroxytryptamine1A (5-HT1A) receptors was determined in the cortex and the hippocampus brain regions of rats. We observed that chronic treatment with both DMI and ECS significantly decreased 5-HT1A receptors, as determined by [3H]8-hydroxy-2-(di-n-propylamino)tetralin [( 3H]8-OH-DPAT) binding, in the cortex but not in the hippocampus. Acute treatment with DMI or ECS did not significantly alter the 5-HT1A receptors in the cortex. Neither chronic nor acute treatment influenced KD of [3H]8-OH-DPAT binding in the cortex or hippocampus. These results thus suggest that in contrast to the effects on 5-HT2 receptors, tricyclics as well as ECS produce similar effects on 5-HT1A receptors, suggesting that this site may represent a common site of action for antidepressant treatment.
Pandey
S C
SC
Illinois State Psychiatric Institute, University of Illinois College of Medicine, Chicago 60612.
Isaac
L
L
Davis
J M
JM
Pandey
G N
GN
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003891:Desipramine / Q000494:pharmacology*; D004597:Electroshock; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D013764:Tetrahydronaphthalenes / Q000378:metabolism / Q000494:pharmacology
D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D003891:Desipramine