title: Single doses of methamphetamine cause changes in the density of dendritic spines in the prefrontal cortex of gerbils (Meriones unguiculatus).
abstract: Single doses of methamphetamine (25 mg/kg) were administered to adult gerbils. All detectable spines were counted along defined segments of basal, apical and lateral dendrites of Golgi-impregnated pyramidal cells in the medial prefrontal cortex (layers III and V) and the parietal cortex (layer V). These two areas were selected because previous investigations had shown methamphetamine-induced neurotoxicity in prefrontal cortex but not in parietal cortex. The frequencies of dendritic spines in methamphetamine-treated gerbils were found to be significantly increased in the prefrontal cortex, while no significant change was found in the parietal cortex.
authors.affiliation: Department of Neuroanatomy, Faculty of Biology, University of Bielefeld, Germany.
authors.forename: R R
authors.initials: RR
authors.lastname: Dawirs
authors.forename: G
authors.initials: G
authors.lastname: Teuchert-Noodt
authors.forename: M
authors.initials: M
authors.lastname: Busse
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000648:ultrastructure; D003712:Dendrites / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D005849:Gerbillinae; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*
chemical_list: D008694:Methamphetamine