[Eventual effect of artemisinine on the experimental infection of mice by Toxoplasma gondii].
Because of taxonomic similarities to previous data found in the literature, and with the aim of improving treatment of toxoplasmosis, we considered it of interest to assay artemisinin, an effective anti-malarial agent, for the treatment of experimental infection in mice by Toxoplasma gondii. Different amounts of the anti-parasitic agent were administered, including after previous contact in vitro with toxoplasma and stimulated macrophage production. With the methodology used artemisinin was not effective. Suggestions for further studies are made.
Amato Neto
V
V
Laboratório de Investigação Médica-Parasitologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brasil.
Braz
L M
LM
Campos
R
R
Pinto
P L
PL
Moreira
A A
AA
Boulos
M
M
Nahkle
M C
MC
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D012717:Sesquiterpenes / Q000627:therapeutic use*; D014122:Toxoplasma / Q000187:drug effects*; D014124:Toxoplasmosis, Animal / Q000517:prevention & control*
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin
Estudo sobre a eventual ação da artemisinina na infecção experimental de camundongos pelo Toxoplasma gondii.