Assembly and intracellular transport of major histocompatibility complex molecules.
Recent advances in our understanding of biosynthesis and assembly of MHC subunits are discussed. Intracellular traffic of MHC proteins is reviewed in the context of antigen presentation. While the overall picture of antigen presentation is now clear, much of the detail of the early stages of assembly of MHC products remains to be established. The degradative pathways that result in the peptides presented by MHC molecules (in particular those serving Class I molecules) have not yet been identified with certainty.
Neefjes
J J
JJ
Netherlands Cancer Institute, Amsterdam.
Schumacher
T N
TN
Ploegh
H L
HL
D000818:Animals; D000938:Antigen-Presenting Cells / Q000378:metabolism*; D001692:Biological Transport; D004705:Endocytosis; D010450:Endopeptidases / Q000378:metabolism; D006680:HLA Antigens / Q000276:immunology / Q000378:metabolism; D006649:Histocompatibility Antigens / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D010446:Peptide Fragments / Q000276:immunology / Q000378:metabolism; D011487:Protein Conformation; D016176:T-Lymphocyte Subsets / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D010446:Peptide Fragments; D010450:Endopeptidases