title: The effect of hydroxyapatite coating on ingrowth of bone into cavities in an implant.
abstract: A canine implant study was performed to assess whether hydroxyapatite (HA) could induce bone to close gaps at the bone-prosthesis junction. Titanium alloy (TiAlV) plates with varying grooves cut into them (1, 2, and 3 mm deep) and identical on both sides were sprayed on one side with HA and left as bare metal on the other. These were then implanted into the distal femora of dogs that were killed 4 and 8 weeks afterwards. Specimens were analyzed using optical microscopy and microradiography. Results show that the presence of HA induces bone to grow almost completely down the deepest groove by 8 weeks. In the 1- and 2-mm grooves at 4 weeks the depth of penetration of bone into the grooves was greater on the HA coated side (but the actual volume of bone in the grooves was greater on the TiAlV side because the bone present was more dense). We conclude that the presence of HA induces bone to close relatively large gaps. Although bone does not grow all the way into uncoated defects there can be more bone here in the short term. This feature of HA may be of great value in hip implant fixation.
authors.affiliation: London Hospital Medical College, England.
authors.forename: P K
authors.initials: PK
authors.lastname: Stephenson
authors.forename: M A
authors.initials: MA
authors.lastname: Freeman
authors.forename: P A
authors.initials: PA
authors.lastname: Revell
authors.forename: J
authors.initials: J
authors.lastname: Germain
authors.forename: M
authors.initials: M
authors.lastname: Tuke
authors.forename: C J
authors.initials: CJ
authors.lastname: Pirie
mesh_terms: D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D004285:Dogs; D017886:Durapatite; D005269:Femur / Q000187:drug effects* / Q000502:physiology; D006621:Hip Joint / Q000601:surgery*; D006622:Hip Prosthesis; D006882:Hydroxyapatites / Q000494:pharmacology*; D011474:Prosthesis Design
chemical_list: D006882:Hydroxyapatites; D017886:Durapatite