Dithiocarbamates of improved efficacy for the mobilization of retained cadmium from renal and hepatic deposits.
The preparation and properties of two novel cadmium-mobilizing dithiocarbamates namely, sodium N-(4-methylbenzyl)-and sodium N-(4-methoxybenzyl)-4-O-(beta-D-galactopyranosyl)-D-glucamine-N-carbo dithioates derived from alpha-lactose and substituted benzylamines are described. These compounds are more effective than previously prepared compounds of this type for the mobilization of cadmium from its aged deposits in both the liver and the kidneys. An examination of the structural features of the more effective compounds for the mobilization of cadmium from its aged deposits reveals that the combination of a high molecular weight with a suitable amphipathic structure in which the polar and non-polar groups are in an appropriate balance are key features. A histopathological evaluation of the animals from which cadmium is removed by these compounds indicates no variations from the normal for the kidney and no evidence of hepatic damage resulting from the removal of the cadmium. On the basis of the trends observed in cadmium mobilizing efficacy, there are grounds for suspecting that agents which are significantly more effective than any prepared so far, should also be accessible.
Jones
M M
MM
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235.
Singh
P K
PK
Jones
S G
SG
Holscher
M A
MA
D000818:Animals; D001212:Asialoglycoproteins / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002104:Cadmium / Q000493:pharmacokinetics*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013859:Thiocarbamates / Q000494:pharmacology*; D014018:Tissue Distribution
D001212:Asialoglycoproteins; D013859:Thiocarbamates; D002104:Cadmium