[Revaccination against hepatitis B in non-responders and in under-responders in a group of mentally handicapped patients].
At 's Koonings Jaght, a community for the mentally handicapped, 330 inhabitants who were seronegative for hepatitis B markers, were vaccinated with a DNA recombinant vaccine. Following primary vaccination, 87% of the inhabitants had an anti-HBs titer of greater than or equal to 10 IU/l while 68% had a titer of greater than or equal to 100 IU/l. It appears from the literature that a certain percentage of the non-responders and hyporesponders still develop sufficient protective antibodies after revaccination, directly following primary vaccination. Besides, it is known from the literature that a titer greater than or equal to 100 IU/l provides prolonged protection. For these reasons, 105 inhabitants whose anti-HBs titers were lower than 100 IU/l following primary vaccination, received one to three additional boosters, depending of the level of the titer. After this revaccination, 92% of the inhabitants had titers greater than or equal to 10 IU/l while 81% had titers greater than or equal to IU/l. From the results of the study it appears that following direct revaccination of non-responders and hyporesponders an additional percentage still reach the protective level of greater than 10 IU/l and that a not inconsiderable percentage achieve a titer providing prolonged protection. The conclusion therefore is that it is useful to revaccinate mentally handicapped persons with no or with low seroconversions following primary vaccination.
Vermeltfoort
J A
JA
's Koonings Jaght, Arnhem.
D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007326:Institutionalization; D008607:Intellectual Disability; D008297:Male; D012307:Risk Factors; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage*
D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines
Revaccinatie tegen hepatitis B bij non- en hyporesponders in een groep geestelijk gehandicapten.