title: [Myocardial contraction and ventricular function in normal subjects evaluated with isotopic ventriculography and phase analysis].
abstract: Normal heart contraction was studied in 20 healthy subjects (14 males and 6 female, mean age 33 years). Rest radioventriculography and phase analysis were used. Ejection fraction was 66 +/- 7% for the LV and 53 +/- 7% for the RV (p < 0.0001). Peak filling rates in the first third of diastole were 1.6 +/- 0.6 EDV/sec for the LV and 0.7 +/- 0.3 EDV/sec for RV (p < 0.0001). Time to peak filling rate normalized for heart rate was 180 +/- 52 ms for the LV and 203 +/- 60 ms for the RV (p = 0.05). Filling fractions were 23 +/- 10% and 9 +/- 3%, respectively (p < 0.0001). Segmental motility was normal in all subjects. Phase analysis revealed faster emptying of the left atrium with phase angles of 171 +/- 13 degrees in the LA and 185 +/- 12 degrees in the RA (p = 0.00007). This difference may be related to faster diastolic events in the left ventricle. Phase angles for the LV and RV were -8.75 +/- 3 and -9.44 +/- 5 degrees, respectively (NS). We conclude that activation occurs earlier in the left atrium, proceeds through the septum and then synchronically over both ventricles.
authors.affiliation: Departamento de Medicina, Hospital Clínico Universidad de Chile, Santiago.
authors.forename: H
authors.initials: H
authors.lastname: Kandora
authors.forename: P
authors.initials: P
authors.lastname: González
authors.forename: R
authors.initials: R
authors.lastname: Lillo
authors.forename: T
authors.initials: T
authors.lastname: Massardo
authors.forename: M
authors.initials: M
authors.lastname: Ortiz
authors.forename: R
authors.initials: R
authors.lastname: Asenjo
authors.forename: R
authors.initials: R
authors.lastname: Oyarzún
authors.forename: I
authors.initials: I
authors.lastname: Aramburu
authors.forename: O
authors.initials: O
authors.lastname: Loureiro
authors.forename: S
authors.initials: S
authors.lastname: Otárola
mesh_terms: D000293:Adolescent; D000328:Adult; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D015635:Radionuclide Ventriculography / Q000379:methods; D013318:Stroke Volume / Q000502:physiology; D016276:Ventricular Function / Q000502:physiology*
vernacular_title: Contracción cardíaca y función ventricular en sujetos normales evaluada con ventriculografía isotópica y análisis de fase.