[Effect of pirenzepine, a selective M1 muscarinic receptor antagonist, on the bronchial tree patency in patients with bronchial asthma].
The effect of a single intravenous dose of pirenzepine on ventilatory indices of 22 asthmatics was studied. The following were assessed: FVC, FEV1, FEF50, FEF25-75, Raw, heart rate (HR) prior administration and after 5, 15, 30, 60, 120, and 180 minutes after receiving 10 mg of pirenzepine. A statistical significant decrease of airflow resistance was seen in control and mild asthmatics (lowering of Raw, FEF25-75). Also an increase of FEV1 was seen in both asthmatic groups. In all patients a decrease of HR was seen.
Siergiejko
Z
Z
Kliniki Alergologii Akademii Medycznej w Bialymstoku.
Rutkowski
R
R
Chyrek-Borowska
S
S
D000328:Adult; D000402:Airway Obstruction / Q000188:drug therapy* / Q000503:physiopathology; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects* / Q000503:physiopathology; D001993:Bronchodilator Agents; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010890:Pirenzepine / Q000008:administration & dosage*; D011976:Receptors, Muscarinic / Q000187:drug effects* / Q000502:physiology; D012119:Respiration / Q000187:drug effects* / Q000502:physiology; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D013997:Time Factors
D001993:Bronchodilator Agents; D011976:Receptors, Muscarinic; D010890:Pirenzepine
Wpływ selektywnego antagonisty receptorów muskarynowych M1--pirenzepiny na drozność drzewa oskrzelowego u chorych na dychawice oskrzelowa.