Failure to detect human papillomavirus sequences at the 3p21 rearrangement site in pleomorphic adenomas.
Eighteen salivary gland pleomorphic adenomas, including nine with a t(3;8)(p21;q12) as the sole chromosome abnormality, were tested for the presence of human papillomavirus (HPV) DNA and for rearrangements of the cellular flanking regions of a HPV 16 integration site mapping to 3p21, as previously described in a cervical carcinoma. In none of the tumors could evidence for either HPV DNA or related sequences, or a rearranged allele of the integration site, be found.
Rommel
B
B
Centre of Human Genetics and Genetic Counselling, University of Bremen, West Germany.
de Villiers
E M
EM
Dürst
M
M
Bartnitzke
S
S
Bullerdiek
J
J
D000236:Adenoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D001483:Base Sequence; D015139:Blotting, Southern; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000235:genetics*; D012468:Salivary Gland Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic
D004273:DNA, Neoplasm; D004279:DNA, Viral