title: Estimation of technetium-99m-MAG3 renal clearance in children: two gamma camera techniques compared with multiple plasma samples.
abstract: Dynamic renal scintigraphy using technetium-99m mercaptoacetylglycylglycylglycine (MAG3) has been described in adults, and clearance values have been established using multiple plasma samples. This study of renal clearance has compared two fundamentally different gamma camera techniques (both of which require a single blood sample) with the multiple blood sampling technique in children (n = 30). Results show that a 40-min dynamic 99mTc-MAG3 renal scintigram coupled with a single plasma sample will allow analysis of the data so that clearance values, which are similar to those from multiple plasma samples, may be calculated. The curve generated from the cardiac region of interest (ROI) provided clearances values that had a high correlation coefficient (0.939-0.951) compared to the multiple-plasma sample technique immaterial of the timing of the blood sample. The renal uptake method of clearance had a lower correlation coefficient (0.89-0.92), which varied with the timing of the blood sample compared to the multiple-plasma sampling technique. This study has demonstrated that an extended gamma camera acquisition coupled with a single-plasma sample may be used for quantitative renal function studies using 99mTc-MAG3.
authors.affiliation: Department of Radiology, Hospital for Sick Children, London, England.
authors.forename: I
authors.initials: I
authors.lastname: Gordon
authors.forename: P J
authors.initials: PJ
authors.lastname: Anderson
authors.forename: M
authors.initials: M
authors.lastname: Orton
authors.forename: K
authors.initials: K
authors.lastname: Evans
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D009842:Oligopeptides / Q000097:blood / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000097:blood / Q000493:pharmacokinetics*; D011866:Radioisotope Renography / Q000379:methods*; D017263:Technetium Tc 99m Mertiatide
chemical_list: D009842:Oligopeptides; D015609:Organotechnetium Compounds; D017263:Technetium Tc 99m Mertiatide