title: A comparison of suture and tubulization nerve repair techniques in a primate.
abstract: This study compared standard methods of nerve repair, epineurial or perineurial sutures with a technique termed fascicular tubulization using a biodegradable polyglycolic acid tube in a nonhuman primate model. Electrophysiologic analysis demonstrated that the percentage of proximal axons that conducted across the repair site did not significantly differ among the three techniques while epineurial suture repairs were associated with significantly longer conduction delays across the repair site compared with the other two techniques. Even though fascicular tubulization using the current polyglycolic acid tube resulted in regeneration equal to the currently perceived best suture repair technique, associated technical problems with the current tube design indicate that this fascicular tubulization technique cannot, at present, be considered as an alternative to present clinically used nerve suture techniques.
authors.affiliation: Rehabilitation Research and Development Center, Veterans Administration Medical Center, Palo Alto, Calif.
authors.forename: V R
authors.initials: VR
authors.lastname: Hentz
authors.forename: J M
authors.initials: JM
authors.lastname: Rosen
authors.forename: S J
authors.initials: SJ
authors.lastname: Xiao
authors.forename: K C
authors.initials: KC
authors.lastname: McGill
authors.forename: G
authors.initials: G
authors.lastname: Abraham
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D001673:Biodegradation, Environmental; D008252:Macaca fascicularis; D008475:Median Nerve / Q000502:physiology / Q000601:surgery*; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D011100:Polyglycolic Acid; D019736:Prostheses and Implants; D013536:Suture Techniques; D014459:Ulnar Nerve / Q000502:physiology / Q000601:surgery*
chemical_list: D011100:Polyglycolic Acid