Analysis of tissue platinum distribution in patients with cancer of the oesophagus.
The objective of this work has been to analyse the repartition of platinum (Pt) tissular levels within the tumour (T), the peritumoral adjacent non-tumoral area (P) and distant healthy tissue of the same anatomical zone (H) in oesophagus cancer. Forty-two biopsies (congruent to 5 mg) have been performed under endoscopy and after informed consent in 11 patients (mean age 61 yr, range 43-74) with squamous cell carcinoma of the oesophagus treated by the neoadjuvant chemotherapy protocol including cisplatin (100 mg/m2) and 5-FU (1 g/m2 x 5 days). Biopsies were done 34-36 h after cisplatin. Additional biopsies were obtained for histological controls. Pt was measured by flameless atomic absorption spectrometry. Considering Pt concentration in T, P and H there was no significant accumulation during repeated treatment (3 cycles). For all cycles, mean [S.D.] values (micrograms/g dry tissue) were 2.03 [2.39] for H, 2.75 [2.03] for P and 3.73 [2.3] for T (H vs. T, P = 0.006). In addition, Pt concentrations were found comparable between the upper and lower poles of the tumours (5 patients). Pt concentrations in T did not predict antitumour activity. These data complete the rather limited knowledge on tissular Pt levels in treated patients and suggest a decreasing gradient of Pt concentrations from tumour to healthy tissue in oesophagus cancer.
Troger
V
V
Institut Jules Bordet, Bruxelles, Belgium.
Francois
E
E
Frenay
M
M
Namer
M
M
Milano
G
G
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D002945:Cisplatin / Q000493:pharmacokinetics / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000737:chemistry* / Q000188:drug therapy; D004947:Esophagus / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D010984:Platinum / Q000032:analysis*
D010984:Platinum; D002945:Cisplatin