title: Vaccination of pigs against Aujeszky's disease by the intradermal route using live attenuated and inactivated virus vaccines.
abstract: Inactivated and live Aujeszky's disease virus vaccines were administered intradermally using a special device without a needle. The 88 pigs were vaccinated at the beginning of the fattening period, both under experimental conditions and in commercial herds. All the pigs were challenged at the end of the fattening period in isolation units. The same vaccines were also injected intramuscularly. Vaccination by the intradermal route induced good protection, similar to that conferred with live virus vaccine injected intramuscularly. The inactivated virus vaccine was not as effective when it was injected by the intradermal route. In animals vaccinated intradermally, there were no local lesions in the meat, but very small nodules were found in the dermis; these do not affect carcass quality. The effects of challenge exposure depended on the initial health of the animals, and a synthetic value (delta G) was used to interpret the data. In fattening pigs, intradermal vaccination required less animal constraint than intramuscular injection; administration could be verified by the presence of a papule at the site of inoculation, and pigs could be vaccinated while they were feeding. Injection without a needle also helps avoid bacterial contamination under farm conditions.
authors.affiliation: Ministère de l'Agriculture, Centre National d'Etudes Vétérinaires et Alimentaires, Ploufragan, France.
authors.forename: P
authors.initials: P
authors.lastname: Vannier
authors.forename: R
authors.initials: R
authors.lastname: Cariolet
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D007117:Immunization, Secondary / Q000009:adverse effects / Q000662:veterinary; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D011557:Pseudorabies / Q000517:prevention & control*; D012867:Skin / Q000473:pathology; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014765:Viral Vaccines