Cyclic AMP level in red blood cells of Plasmodium berghei-infected Mastomys natalensis.
The present report describes the changes in cyclic AMP level which occur upon parasitization of red cells by Plasmodium berghei. Parasitized erythrocytes were separated from the non-parasitized population by percoll density-gradient centrifugation. An increase in the cyclic AMP content of both non-parasitized and parasitized erythrocytes of infected animals compared with that of uninfected animals was observed. The patterns of physiological response to isoproterenol in normal, parasitized and non-parasitized erythrocytes were identical.
Khare
S
S
Division of Biochemistry, Faculty of Science, M.S. University of Baroda, India.
Ghatak
S
S
D000818:Animals; D000242:Cyclic AMP / Q000032:analysis* / Q000096:biosynthesis; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology; D007545:Isoproterenol / Q000494:pharmacology; D008288:Malaria / Q000097:blood*; D008297:Male; D009115:Muridae; D010962:Plasmodium berghei / Q000302:isolation & purification*; D011433:Propranolol / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D011433:Propranolol; D013806:Theophylline; D000242:Cyclic AMP; D007545:Isoproterenol