T-cell memory: the connection between function, phenotype and migration pathways.
Immunological memory is a fundamental feature of vertebrate immune systems, providing enhanced protection against previously encountered antigens. The established view has been that immunological memory results from clonal expansion and long-term survival of specialized memory cells. Recently, the nature of memory T cells has come under closer scrutiny because of the ability to distinguish naive and memory T cells phenotypically, particularly in humans. In this article, Charles Mackay discusses three features of memory T cells that help to explain the nature and function of these cells: the increased expression of adhesion and activation molecules on memory T cells, their potent functional status and their specific pathways of recirculation.
Mackay
C R
CR
Basel Institute for Immunology, Switzerland.
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D016130:Immunophenotyping; D017493:Leukocyte Common Antigens; D008213:Lymphocyte Activation / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D006649:Histocompatibility Antigens; D017493:Leukocyte Common Antigens