Updating the procedure for metaiodobenzylguanidine labelling with iodine radioisotopes employed in industrial production.
The classical procedure used for the preparation of [125I]- and [131I]metaiodobenzylguanidine (MIBG) is the solid-phase isotopic exchange between MIBG and radioiodide. This reaction requires 1.5 hours at 160 degrees C to obtain maximum total labelling yields of 75-80%. Recently, the importance of rapid procedures for the preparation of 123I-MIBG has been highlighted. A highly efficient procedure for the industrial production of 123I-MIBG using ascorbic acid, tin sulfate and copper sulfate pentahydrate in 0.01 M sulfuric acid is reported. Sequential radio-TLC analysis of the labelling mixture shows that the labelling yield reaches 98% within 45 min at 100 degrees C. The specific activity of the 123I-MIBG produced in this manner is on the order of 100 Ci/mmol.
Franceschini
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R
Sorin Biomedica SpA, Radiopharmaceutical Division, Research and Development Department, Saluggia, Vercelli, Italy.
Mosca
R
R
Bonino
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C
D019797:3-Iodobenzylguanidine; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D007553:Isotope Labeling / Q000379:methods*
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine