Expression of type 1 blood group precursor in human gastric carcinoma.
The surface epithelium of normal gastric mucosa from patients with gastric adenocarcinoma expressed the type 1 blood group precursor only in Lewis (Le) non-secretor individuals, Le a+b- (se/se, Le/-) and Le a-b- (se/se, le/le). In secretors, the superficial mucosa was negative. Deep areas of the mucosa showed no type 1 precursor regardless of secretor status. Expression of type 1 precursor was anomalously found in neoplastic cells in 14 of 16 Le a-b+ (secretors) patients and in 4 of 5 Le a-b- (secretors) patients. The 1 Le a-b- non-secretor carcinoma expressed type 1 precursor strongly. 6 of 8 Le a+b- non-secretor carcinomas showed positivity for the monoclonal antibody K-21. Thus the type 1 precursor reacted with the non-neoplastic gastric surface of non-secretors but not with those of secretors, and also with most gastric adenocarcinoma regardless of secretor status and Lewis phenotype.
Blasco
E
E
Pathology Unit, Hospital Nuestra Señora de Arantzazu, San Sebastián, Spain.
Gutierrez-Hoyos
A
A
Lojendio
M
M
Cosme
A
A
Arenas
J I
JI
D000230:Adenocarcinoma / Q000097:blood*; D000911:Antibodies, Monoclonal; D005753:Gastric Mucosa / Q000276:immunology; D006801:Humans; D007519:Isoantigens / Q000032:analysis; D007983:Lewis Blood Group Antigens; D011498:Protein Precursors / Q000032:analysis*; D013274:Stomach Neoplasms / Q000097:blood*
D000911:Antibodies, Monoclonal; D007519:Isoantigens; D007983:Lewis Blood Group Antigens; D011498:Protein Precursors