title: Occupational triphenyltin acetate poisoning: a case report.
abstract: A case of triphenyltin acetate (TPTA) poisoning is described. The patient, who had been exposed mainly to cutaneous absorption, showed acute stages of an urticarial eruption, signs of hepatic injury, slight glucose intolerance, and electroencephalographic abnormalities. Concomitant with the highest concentrations of tin in plasma and the peak of tin excretion in urine, neutrophils did not show the normal increase in actin polymerisation after stimulation with a chemotactic peptide (100 nM fMLP). The peak of urinary excretion of tin occurred between the fifth and the sixth day after poisoning; subsequently, the rate of excretion became slow, suggesting biphasic kinetics with the possibility of a cumulative trend.
authors.affiliation: Istituto di Medicina del Lavoro, Università degli Studi di Milano, Italia.
authors.forename: C
authors.initials: C
authors.lastname: Colosio
authors.forename: M
authors.initials: M
authors.lastname: Tomasini
authors.forename: S
authors.initials: S
authors.lastname: Cairoli
authors.forename: V
authors.initials: V
authors.lastname: Foà
authors.forename: C
authors.initials: C
authors.lastname: Minoia
authors.forename: M
authors.initials: M
authors.lastname: Marinovich
authors.forename: C L
authors.initials: CL
authors.lastname: Galli
mesh_terms: D000328:Adult; D009783:Dermatitis, Occupational / Q000139:chemically induced* / Q000473:pathology / Q000652:urine; D004569:Electroencephalography / Q000187:drug effects; D005659:Fungicides, Industrial / Q000506:poisoning*; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D009947:Organotin Compounds / Q000506:poisoning*; D012867:Skin / Q000473:pathology; D012869:Skin Absorption; D014001:Tin / Q000652:urine; D014581:Urticaria / Q000139:chemically induced* / Q000473:pathology / Q000652:urine
chemical_list: D005659:Fungicides, Industrial; D009947:Organotin Compounds; C011978:phentin acetate; D014001:Tin