title: [Clinical investigation of 9 cases of urachal carcinoma].
abstract: Recently, we encountered 9 cases of urachal tumor and conducted clinical studies on its diagnosis and treatment. The chief complaint was gross hematuria in all cases. Computed tomographic scan was performed in 7 cases, and in all cases it revealed a tumor between the dome of the bladder and the Retzius' cavity. This finding strongly suggested a urachal tumor before pathological study. Magnetic imaging resonance (MIR) was performed in one of the 9 cases, and it indicated the extent of the tumor more clearly than computed tomography. Partial cystectomy + en bloc removal of the umbilicus and urachus was performed in 5 cases, radical cystectomy + en bloc removal of the umbilicus and urachus was performed in 2 cases, and radical cystectomy was performed in 2 cases. As postoperative therapy, radiotherapy was administered to 4 cases, and chemotherapy was administered to 4 cases. One case died from cancer after 4 years and 10 months, while the other 8 cases are being treated on an outpatient basis without any local recurrence. All 5 patients who underwent partial cystectomy are alive (mean survival time: 97 months). Thus we believe that cure can be achieved by partial cystectomy and adjuvant therapy. In addition, serum carcinoembryonic antigen is thought to be useful as an indicator of residual tumor or local recurrence.
authors.affiliation: Department of Urology, Jikei University School of Medicine, Aoto Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Iizuka
authors.forename: S
authors.initials: S
authors.lastname: Onodera
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.forename: J
authors.initials: J
authors.lastname: Kuroda
authors.forename: H
authors.initials: H
authors.lastname: Shirakawa
authors.forename: T
authors.initials: T
authors.lastname: Hosobe
authors.forename: T
authors.initials: T
authors.lastname: Takasaka
authors.forename: T
authors.initials: T
authors.lastname: Machida
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: Y
authors.initials: Y
authors.lastname: Kawashima
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014497:Urachus / Q000601:surgery
chemical_list: D002272:Carcinoembryonic Antigen