[Inhibition by dehydroepiandrosterone of aggression responses of spayed female mice towards lactating intruders is potentiated by neonatal androgenization].
Female mice of an inbred Swiss strain were injected subcutaneously (s.c.) with either testosterone propionate or oil-vehicle on the day of birth. Once adult (8 week-old), they were spayed, and then treated either with dehydroepiandrosterone (80 micrograms/day s.c. for 15 days) or with solvent. The decrease of biting attacks by dehydroepiandrosterone was definitely more prominent in neonatally imprinted females than in controls.
Haug
M
M
C.N.R.S., U.R.A., 1295, Laboratoire de Psychophysiologie, Strasbourg.
Young
J
J
Robel
P
P
Baulieu
E E
EE
D000818:Animals; D003687:Dehydroepiandrosterone / Q000494:pharmacology* / Q000627:therapeutic use; D004357:Drug Synergism; D005260:Female; D007774:Lactation / Q000523:psychology; D051379:Mice; D010052:Ovariectomy / Q000523:psychology*; D011247:Pregnancy; D013312:Stress, Physiological / Q000188:drug therapy*; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D003687:Dehydroepiandrosterone
L'inhibition par le déhydroépiandrostérone des réponses agressives de souris femelles castrées vis-à-vis d'intruses allaitantes est potentialisée par l'androgénisation néonatale.