Hepatocyte swelling increases inositol 1,4,5-trisphosphate, calcium and cyclic AMP concentration but antagonizes phosphorylase activation by Ca2(+)-dependent hormones.
Swelling of hepatocytes increases the concentration of inositol 1,4,5-trisphosphate, Ca2+ and cAMP, without activating glycogen phosphorylase. In these hepatocytes, the activation of phosphorylase by suboptimal concentrations of vasopressin or angiotensin II was partly antagonized.
Baquet
A
A
Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels, Belgium.
Meijer
A J
AJ
Hue
L
L
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D004789:Enzyme Activation; D005973:Glutamine / Q000494:pharmacology; D006006:Glycogen Synthase / Q000378:metabolism; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D006005:Phosphorylases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051381:Rats; D014667:Vasopressins / Q000494:pharmacology
D005973:Glutamine; D014667:Vasopressins; D015544:Inositol 1,4,5-Trisphosphate; D000242:Cyclic AMP; D006005:Phosphorylases; D006006:Glycogen Synthase; D002118:Calcium