title: Suppressive effects of dehydroepiandrosterone and 3 beta-methyl-androst-5-en-17-one on attack towards lactating female intruders by castrated male mice. II. Brain neurosteroids.
abstract: Dehydroepiandrosterone (DHA) and 3 beta-methyl-androst-5-en-17-one (CH3-DHA) suppress attacks by castrated male mice towards lactating female intruders (Haug et al. Physiol. Behav. 46:955, 1989). Their effects on the concentrations of DHA, pregnenolone (delta 5P), and their sulfate ester (S) have been investigated in the brain of control and treated mice. A more than 2 fold, significant, decrease of delta 5P-S was the only change common to both steroids. DHA and CH3-DHA effects might be related to the antagonistic action of delta 5P-S on GABAA receptors.
authors.affiliation: INSERM U33, Lab. Hormones, Bicêtre, France.
authors.forename: J
authors.initials: J
authors.lastname: Young
authors.forename: C
authors.initials: C
authors.lastname: Corpéchot
authors.forename: M
authors.initials: M
authors.lastname: Haug
authors.forename: S
authors.initials: S
authors.lastname: Gobaille
authors.forename: E E
authors.initials: EE
authors.lastname: Baulieu
authors.forename: P
authors.initials: P
authors.lastname: Robel
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000736:Androstenes / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D007774:Lactation; D008297:Male; D051379:Mice; D009919:Orchiectomy; D011284:Pregnenolone / Q000378:metabolism; D013256:Steroids / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism
chemical_list: D000736:Androstenes; D013256:Steroids; D013739:Testosterone; D003687:Dehydroepiandrosterone; D011284:Pregnenolone; C040993:3-methylandrost-5-en-17-one