title: Noncardiac surgery in heart transplant recipients in the cyclosporine era.
abstract: As survival and quality of life continue to improve for cardiac transplant recipients, there is an ever-increasing possibility that these patients will present for elective and/or emergency surgery outside of a transplantation center. Cyclosporine therapy has been a major factor in extending homograft survival, but recent studies have suggested that cyclosporine administration increases the duration of action of some anesthetics. The authors evaluated the influence on anesthetic management of cardiac transplantation and chronic cyclosporine therapy in a retrospective review of all postcardiac transplant patients who presented for noncardiac surgery at the study institution. The data suggest that a number of commonly used anesthetic techniques can be administered safely to these patients when no evidence of graft rejection is present. No clinically significant prolongation of anesthetic effect was encountered following the doses of anesthetics described.
authors.affiliation: Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY.
authors.forename: J A
authors.initials: JA
authors.lastname: Melendez
authors.forename: E
authors.initials: E
authors.lastname: Delphin
authors.forename: J
authors.initials: J
authors.lastname: Lamb
authors.forename: E
authors.initials: E
authors.lastname: Rose
mesh_terms: D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000775:Anesthesia, Spinal; D001794:Blood Pressure / Q000502:physiology; D003524:Cyclosporins / Q000627:therapeutic use*; D005283:Fentanyl; D006339:Heart Rate / Q000502:physiology; D016027:Heart Transplantation; D006801:Humans; D008874:Midazolam; D003473:Neuromuscular Nondepolarizing Agents; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative; D013874:Thiopental
chemical_list: D003524:Cyclosporins; D003473:Neuromuscular Nondepolarizing Agents; D013874:Thiopental; D008874:Midazolam; D005283:Fentanyl