title: The effect of aminoguanidine on the blood-retinal barrier in streptozocin-induced diabetic rats.
abstract: The effect of aminoguanidine hydrochloride (AG) on the blood-retinal barrier was studied in rats with streptozocin-induced diabetes. Half of the rats were given AG (100 mg/kg/day) while the remainder received no treatment. Vitreous fluorophotometry was performed on all rats before STZ injection and 2 weeks after induction of diabetes mellitus. Two weeks after STZ injection the mean 60-minute vitreous fluorescein concentration following dye injection had increased more in the nontreated group than in the AG-treated group, suggesting that AG may have some beneficial effect on the breakdown of the blood-retinal barrier.
authors.affiliation: LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans 70112.
authors.forename: H K
authors.initials: HK
authors.lastname: Cho
authors.forename: H
authors.initials: H
authors.lastname: Kozu
authors.forename: G A
authors.initials: GA
authors.lastname: Peyman
authors.forename: G J
authors.initials: GJ
authors.lastname: Parry
authors.forename: B
authors.initials: B
authors.lastname: Khoobehi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001813:Blood-Retinal Barrier; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism*; D015590:Fluorophotometry; D006146:Guanidines / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin; D014822:Vitreous Body / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D006146:Guanidines; D013311:Streptozocin; C004479:pimagedine