19F-MRI of stomach and intestine using 50% FTPA emulsion under 2 T MRI system.
1H-MRI is of clinical value in many lesions, but imaging of gastrointestinal lesions is still difficult by 1H-MRI. To overcome this weak point of 1H-MRI, rabbit stomachs were examined by 19F-MRI using 50% FTPA emulsion. We also examined the stability of 50% FTPA emulsion in the stomach and its absorption from the gastrointestinal tract. We found that 50% FTPA emulsion was very stable at pH 1.5, and only a very small amount was absorbed. A rabbit (weighing 2 kg) was anesthetized, and 100 ml of 50% FTPA emulsion was infused into the stomach by catheter. 19F-MRI was performed in this rabbit using a 2 T superconducting MRI system designed for human use, and clear pictures of the stomach were obtained. From our results we conclude that 19F-MRI of the stomach using 50% FTPA emulsion is of practical value.
Shimizu
M
M
Second Department of Surgery, Osaka University School of Medicine, Japan.
Kobayashi
T
T
Mishima
H
H
Tamaki
Y
Y
Shimano
T
T
Shimizu
C
C
Higuchi
Y
Y
Yamamoto
S
S
Itoh
S
S
Yamazaki
M
M
D000818:Animals; D003287:Contrast Media; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D007408:Intestinal Absorption; D007422:Intestines / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011817:Rabbits; D013270:Stomach / Q000033:anatomy & histology*
D003287:Contrast Media; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination