HLA antigens in patients with chronic inflammatory demyelinating polyneuropathy.
In a group of 52 patients with a chronic inflammatory demyelinating polyneuropathy (CIDP), no significant associations were found with any of the HLA-A, B, C, DR or DQ antigens. No HLA association was found between the presence or absence of anti-neural antibodies or between the group of patients improving or not improving after intravenous immunoglobulin. These findings mean that we could not confirm results from the literature that suggest that CIDP is associated with the HLA-A1,B8,DR3 haplotype or--as recently was suggested--with the HLA-Cw7 or DR2 antigen.
van Doorn
P A
PA
Department of Neurology, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Schreuder
G M
GM
Vermeulen
M
M
d'Amaro
J
J
Brand
A
A
D000906:Antibodies / Q000032:analysis; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis; D006683:HLA-DQ Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D008297:Male; D010525:Peripheral Nerves / Q000276:immunology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000276:immunology*
D000906:Antibodies; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D007136:Immunoglobulins