Sodium dependent inositol transport in HL60 cells is not related to Na+/K+ ATPase activity.
In HL60 cells, inositol transport is sodium-dependent but functionally independent of Na+/K+ ATPase activity. This observation has implications for the currently proposed theory for the development of diabetic complications.
Baxter
M A
MA
Department of Medicine, University of Birmingham, UK.
Grafton
G
G
Bunce
C M
CM
Sheppard
M C
MC
Brown
G
G
D001692:Biological Transport / Q000187:drug effects; D002460:Cell Line; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D007700:Kinetics; D015473:Leukemia, Promyelocytic, Acute; D010042:Ouabain / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D007294:Inositol; D010042:Ouabain; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D005947:Glucose