title: Difluoromethyl ornithine protects against the neurotoxic effects of intrastriatally administered N-methyl-D-aspartate in vivo.
abstract: The neurotoxic effects of intrastriatally administered N-methyl-D-aspartate (NMDA) (250 nmol), as measured by reductions in striatal choline acetyl transferase activity and by increased binding of the glial marker [3H]PK 11195 10 days later, were reduced by coinfusion of the irreversible ornithine decarboxylase inhibitor difluoromethylornithine (250 nmol) in the rat. The data suggest a crucial role for the polyamines in NMDA receptor-mediated neurotoxicity.
authors.affiliation: Synthélabo Recherche (L.E.R.S.), Bagneux, France.
authors.forename: A
authors.initials: A
authors.lastname: Porcella
authors.forename: D
authors.initials: D
authors.lastname: Fage
authors.forename: C
authors.initials: C
authors.lastname: Voltz
authors.forename: C
authors.initials: C
authors.lastname: Carter
authors.forename: B
authors.initials: B
authors.lastname: Scatton
authors.forename: G
authors.initials: G
authors.lastname: Bartholini
mesh_terms: D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D000518:Eflornithine / Q000494:pharmacology*; D007546:Isoquinolines / Q000378:metabolism; D008297:Male; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects
chemical_list: D007546:Isoquinolines; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D002795:Choline O-Acetyltransferase; C037850:PK 11195; D000518:Eflornithine