Signal transduction in T cells.
Rapid progress was made during the past year in the delineation of the nature of the initial biochemical events triggered by the T-cell antigen receptor. Antigen-mediated activation of phospholipase C was demonstrated to require protein tyrosine phosphorylation and, most surprising, activation of the Ras family of signal transduction molecules was shown to closely follow stimulation of the T-cell antigen receptor. Major controversy continues over which events are relevant to the various effector functions of T cells.
June
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Cell Biology Program, Naval Medical Research Institute, Bethesda, Maryland 20889-5055.
D000818:Animals; D006801:Humans; D008213:Lymphocyte Activation; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell; D015398:Signal Transduction / Q000276:immunology* / Q000502:physiology; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D010738:Type C Phospholipases / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D010738:Type C Phospholipases