title: Synthesis and characterization of flavin modified oligodeoxyribonucleotide.
abstract: Oligonucleotides covalently linked to isoalloxazines via polymethylene linker were synthesized and characterized. The thymidine decamer having a primary aminoalkyl group at the 5'-end of internucleotide linkage was coupled with the activated ester of isoalloxazine in liquid-phase. The interaction of the flavin modified thymidine decamers with polydA was investigated by using spectrophotometric method.
authors.affiliation: Faculty of Pharmaceutical Science, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Akiyama
authors.forename: F
authors.initials: F
authors.lastname: Yoneda
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: J
authors.initials: J
authors.lastname: Kuwabara
authors.forename: Y
authors.initials: Y
authors.lastname: Sugiura
mesh_terms: D001483:Base Sequence; D005415:Flavins / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005415:Flavins; D009838:Oligodeoxyribonucleotides