[CD8+T-cell lymphocytic alveolitis in sarcoidosis. 4 cases].
We report 4 cases of histologically proven sarcoidosis with lymphocytic alveolitis. The T CD4+/T CD8+ ratio was below 1 in the bronchoalveolar lavage fluid. Since there was no clinical and paraclinical evidence of extrinsic allergic alveolitis or HIV infection, and since 3 of the patients were nonsmokers and the 4th one smoked moderately, we considered that the T CD8+ lymphocytic alveolitis was related to the sarcoidosis. In 3 patients the presence of mediastinal adenopathy suggested that sarcoidosis was of recent onset. The fact that T CD4+/T CD8+ ratio was normal in blood indicated that T CD8+ lymphocytes were predominant only in the lung. Thus, the finding of T CD8+ lymphocytic alveolitis should not exclude a diagnosis of sarcoidosis.
Quint
L
L
Service de Pneumologie, Hôpital Avicenne, Bobigny.
Sadoun
D
D
Valeyre
D
D
Soler
P
P
Georges
R
R
Battesti
J P
JP
D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis; D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology; D007958:Leukocyte Count; D008171:Lung Diseases / Q000209:etiology; D008875:Middle Aged; D011650:Pulmonary Alveoli; D012507:Sarcoidosis / Q000150:complications*; D013601:T-Lymphocytes / Q000378:metabolism
D015703:Antigens, CD
Alvéolite lymphocytaire à lymphocytes T CD8+ au cours de la sarcoïdose. 4 observations.