Milacemide enhances memory storage and alleviates spontaneous forgetting in mice.
The objective of this study was to evaluate the effectiveness of milacemide as a memory-enhancing drug in mice. Experiment 1 showed that forgetting of active avoidance learning produced by a 14-day training to test delay could be alleviated by milacemide (10 mg/kg) administered before the retention test. Experiment 2 demonstrated that the same dose of milacemide could also attenuate spontaneous forgetting of passive avoidance learning, thereby ruling out nonspecific effects as an explanation for the enhancement of performance following pretesting drug administration. A third experiment showed that the facilitation of retrieval induced by milacemide could be blocked by the NMDA receptor antagonist AP-7, suggesting that the effects of milacemide on memory may be mediated by NMDA receptor activation. A final experiment demonstrated that retention was improved when milacemide was administered immediately following active avoidance training, indicating that the drug can also facilitate remembering by its actions on consolidation and storage processes.
Quartermain
D
D
Department of Neurology, New York University Medical Center, NY 10016.
Nuygen
T
T
Sheu
J
J
Herting
R L
RL
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000081:Acetamides / Q000494:pharmacology*; D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects
D000081:Acetamides; D000596:Amino Acids; D008996:Monoamine Oxidase Inhibitors; D016194:Receptors, N-Methyl-D-Aspartate; C039332:milacemide; D015763:2-Amino-5-phosphonovalerate; C031231:2-amino-7-phosphonoheptanoic acid