title: [Effects of berberine on synthesis of platelet TXA2 and plasma PGI2 in rabbits].
abstract: Using radioimmunoassay, we found that berberine (0.50 mol.L-1) inhibited dose-dependently collagen-, ADP-, and arachidonic acid (AA)-induced TXA2 release from platelets. Berberine (25 mg.kg-1) iv lowered rabbit plasma level of PGI2 from 0.92 +/- 0.20 to 0.61 +/- 0.08 ng.ml-1 after 60 min. The results suggest that berberine inhibits AA release from cell membrane phospholipids and its metabolism.
authors.affiliation: Department of Biochemistry, Second Military Medical University, Shanghai, China.
authors.forename: C G
authors.initials: CG
authors.lastname: Huang
authors.forename: Z L
authors.initials: ZL
authors.lastname: Chu
authors.forename: Z M
authors.initials: ZM
authors.lastname: Yang
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D005260:Female; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013929:Thromboxane B2 / Q000097:blood*
chemical_list: D010975:Platelet Aggregation Inhibitors; D001599:Berberine; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha