title: Platelet behaviour and haemostatic variables in type 1 (insulin-dependent) diabetic patients with and without albuminuria.
abstract: Abnormalities of haemostasis have been implicated in the development of both large and small vessel disease in diabetes. Platelet behaviour and coagulation factors were studied in 28 non-diabetic control subjects and 81 Type 1 diabetic patients with different degrees of albuminuria. Twenty-four (30%) patients had macro- or micro-albuminuria. These patients had elevated levels of beta-thromboglobulin compared with normo-albuminuric patients and control subjects (macro-albuminuric 113 (range 60-314), micro-albuminuric 88 (50-220), normo-albuminuric 55 (13-273), control 52 (18-210) micrograms l-1, p less than 0.001). Similar results were found for platelet factor 4 (macro-albuminuric 57 (9-350), micro-albuminuric 78 (12-205), normo-albuminuric 10 (2-135), control 9 (3-95) micrograms l-1, p less than 0.001). There were decreased beta-thromboglobulin:platelet factor 4 ratios in the albuminuric patients compared with control subjects and normo-albuminuric patients (p less than 0.001). There is abnormal platelet activity in Type 1 diabetic patients with elevated albumin excretion rates.
authors.affiliation: Department of Medicine, University of Birmingham, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: O'Donnell
authors.forename: C A
authors.initials: CA
authors.lastname: Le Guen
authors.forename: N
authors.initials: N
authors.lastname: Lawson
authors.forename: O H
authors.initials: OH
authors.lastname: Gyde
authors.forename: A H
authors.initials: AH
authors.lastname: Barnett
mesh_terms: D000328:Adult; D000419:Albuminuria; D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation; D001792:Blood Platelets / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000652:urine; D003928:Diabetic Nephropathies / Q000097:blood / Q000175:diagnosis; D005169:Factor VIII / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D008297:Male; D015539:Platelet Activation; D010974:Platelet Aggregation; D010978:Platelet Factor 4 / Q000032:analysis; D012016:Reference Values; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D000990:Antithrombin III; D005169:Factor VIII; D005340:Fibrinogen