[Determination of the neurotransmitters 5-hydroxytryptamine, noradrenaline, and dopamine in gastroduodenal mucosa. Clinical and histologic correlation].
We have studied the concentrations (pg/mg) of Neurotransmitters 5-hydroxytryptamine (5HT), Noradrenaline (NA) and Dopamine (DA) at mucosa normal and with different degrees of chronic inflammation mucosa of fundus (F), antrum (A) and duodenum (D) in 21 patients. We correlated the concentration of the neurotransmitters with each other, all of them in each region and with clinics, indirect of motility and histologic parameters. The average for 5HT in F: 940.2 +/- 457.4; in A: 787.5 +/- 407.0; in D: 601.6 +/- 272.0; for NA in F: 217.5 +/- 138.7; in A: 228.4 +/- 126.5; in D: 245.7 +/- 118.6 for DA in F: 50.7 +/- 32.2; in A: 46.3 +/- 31.5; in D: 53.0 +/- 45.6. The statistical analysis showed a significant correlation of DA concentration with lymphoplasmocytic infiltrated in Duodenum (r = 0,94). not any other parameter had significative relation with the neurotransmitters variations. We established that the variations of the neurotransmitter concentrations of the antrum mucosa are more associated with the duodenum than with the gastric fundus.
Sánchez
D
D
Cátedra de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, República Argentina.
Rodríguez
E
E
Jorge
A
A
Cabrera
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004298:Dopamine / Q000032:analysis*; D004386:Duodenum / Q000737:chemistry*; D005260:Female; D005748:Gastric Fundus / Q000737:chemistry; D005753:Gastric Mucosa / Q000737:chemistry*; D006801:Humans; D007413:Intestinal Mucosa / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000032:analysis*; D011706:Pyloric Antrum / Q000737:chemistry; D012701:Serotonin / Q000032:analysis*
D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine
Investigaciones de los neurotransmisores 5-hidroxitriptamina, noradrenalina y dopamina, en mucosa gastroduodenal. Correlación clínica e histológica.