title: About the presence of a circulating anti-alkaline phosphatase antibody in a trisomy 21 patient's serum.
abstract: An electrophoretically slow-moving alkaline phosphatase was found in the serum of a 17-year-old patient with Down's syndrome. Immunological and biochemical studies suggested that this abnormal enzyme pattern consisted of a complex of liver/bone isoenzyme with kappa-type immunoglobulins A and G.
authors.affiliation: Laboratoire d'Immunopathologie rénale, INSERM CJF 88 01, Faculté de Médecine, Toulouse-Rangueil, France.
authors.forename: A
authors.initials: A
authors.lastname: Brissson-Lougarre
authors.forename: H
authors.initials: H
authors.lastname: Vergnes
authors.forename: J
authors.initials: J
authors.lastname: Grozdea
mesh_terms: D000293:Adolescent; D000469:Alkaline Phosphatase / Q000737:chemistry*; D004314:Down Syndrome / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D007070:Immunoglobulin A / Q000737:chemistry; D007074:Immunoglobulin G / Q000737:chemistry; D007145:Immunoglobulin kappa-Chains / Q000737:chemistry; D007527:Isoenzymes; D046911:Macromolecular Substances; D008297:Male
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007527:Isoenzymes; D046911:Macromolecular Substances; D000469:Alkaline Phosphatase