Screening for corticosteroid contact sensitivity. Comparison of tixocortol pivalate, hydrocortisone-17-butyrate and hydrocortisone.
3 corticosteroids have so far been tried as markers for corticosteroid contact sensitivity: hydrocortisone, tixocortol pivalate and hydrocortisone-17-butyrate. The present study compared these steroids for screening in addition to a standard patch test series. Of 727 patients, 28 (3.9%) reacted to tixocortol pivalate and 10 (1.4%) to hydrocortisone-17-butyrate; hydrocortisone gave an allergic reaction in 2 of 521 (0.4%) patients. Serial dilutions suggested that tixocortol pivalate, not marketed in Finland, caused allergic reactions which could possibly be cross-reactions to hydrocortisone. In contrast to previously published data, frequent cross-reactions occurred with hydrocortisone-17-butyrate and tixocortol pivalate. All allergic reactions to other corticosteroids found by testing with tixocortol pivalate concurred with reactions to hydrocortisone-17-butyrate. The study suggests that the most effective choice for routine testing for corticosteroid contact sensitivity would be both tixocortol pivalate and hydrocortisone-17-butyrate.
Lauerma
A I
AI
Department of Dermatology, Helsinki University Central Hospital, Finland.
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000175:diagnosis* / Q000209:etiology; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology; D005387:Finland; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects / Q000031:analogs & derivatives; D010328:Patch Tests; D012189:Retrospective Studies
D000893:Anti-Inflammatory Agents; C007975:hydrocortisone-17-butyrate; C019112:tixocortol pivalate; D006854:Hydrocortisone