Substance P-like immunoreactivity and somatostatin-like immunoreactivity in the ventricular fluid of patients with chronic pain syndromes.
Substance P-like and somatostatin-like immunoreactivities (SPLI and SLI) were determined in ventricular fluid of patients with chronic pain syndromes and in a comparison group with multiple sclerosis, essential tremor, epilepsy and postanoxic myoclonus. Concentrations of SPLI and SLI were non-significantly decreased by 40% and 33% in chronic pain patients as compared with control patients without pain. There were no differences apparent between subgroups of pain patients (deafferentation pain, neoplasia-induced pain, thalamic pain). High pressure liquid chromatography combined with radioimmunoassay showed marked heterogeneity of SPLI and SLI.
Jost
S
S
Department of Neurology, University of Freiburg, Federal Republic of Germany.
Reuner
C
C
Geiger
J
J
Mohadjer
M
M
Milios
E
E
Cramer
H
H
D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000134:cerebrospinal fluid*; D010455:Peptides / Q000134:cerebrospinal fluid*; D011863:Radioimmunoassay
D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C029993:somatostatin-like peptides; C016116:substance P-like peptides