Dietary sodium intake: influence on calcium channels and urinary calcium excretion in spontaneously hypertensive rats.
Binding of the 1,4-dihydropyridine [3H]PN200 110 was employed as an index of cardiac Ca2+ channels in normotensive (WKY) and spontaneously hypertensive (SHR) rats during 4 weeks of normal (0.73% NaCl) and high (8% NaCl) sodium diets when the rats were between 20 and 24 weeks of age. Binding site density was not different at the beginning of the study but was increased significantly (P less than 0.01) after 1 week in the SHR on a high sodium diet; this difference was not apparent at 2, 3 or 4 weeks of the diet. During this same period, the urinary Ca2+ excretion in SHR was enhanced significantly (P less than 0.01) and the urinary calcium/sodium ratio was elevated during the high sodium intake period.
Galletti
F
F
Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo 14260.
Rutledge
A
A
Triggle
D J
DJ
D000818:Animals; D001665:Binding Sites; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000652:urine; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D004095:Dihydropyridines / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism* / Q000652:urine; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D012982:Sodium, Dietary / Q000008:administration & dosage* / Q000494:pharmacology
D015220:Calcium Channels; D004095:Dihydropyridines; D012982:Sodium, Dietary; C038806:1,4-dihydropyridine; D012964:Sodium; D002118:Calcium