The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase.
The multigene family of human Na,K-ATPase is composed of 5 alpha-subunit genes, 3 of which were shown to encode the functionally active alpha 1, alpha 2 and alpha 3 isoforms of the catalytic subunits. This report describes the isolation, mapping and partial sequencing of the fourth gene (ATP1AL1) that was demonstrated here to be functionally active and expressed in human brain and kidney. Limited DNA sequencing of the ATP1AL1 exons allowed one to suggest that the gene probably encodes a new ion transport ATPase rather than an isoform of the Na,K-ATPase or the closely related H,K-ATPase.
Modyanov
N N
NN
Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.
Petrukhin
K E
KE
Sverdlov
V E
VE
Grishin
A V
AV
Orlova
M Y
MY
Kostina
M B
MB
Makarevich
O I
OI
Broude
N E
NE
Monastyrskaya
G S
GS
Sverdlov
E D
ED
D000251:Adenosine Triphosphatases / Q000235:genetics* / Q000378:metabolism; D000595:Amino Acid Sequence; D001483:Base Sequence; D001692:Biological Transport; D001921:Brain / Q000201:enzymology; D004587:Electrophoresis, Agar Gel; D005091:Exons; D006801:Humans; D007438:Introns; D007668:Kidney / Q000201:enzymology; D008969:Molecular Sequence Data; D005810:Multigene Family; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics*; D014158:Transcription, Genetic
D015345:Oligonucleotide Probes; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase