title: Hepatocellular carcinoma as second malignant neoplasms in successfully treated Wilms' tumor patients. A National Wilms' Tumor Study report.
abstract: Although rare, second malignant neoplasms (SMN) after treatment for Wilms' tumor are deadly. A recent National Wilms' Tumor Study (NWTS) report identified 15 patients with second malignancies discovered over 14,381 person-years of observation. This report described four patients with secondary hepatocellular carcinoma in greater detail. These patients were strikingly similar in that all had right-sided tumors and each one had received right upper-quadrant irradiation. All patients died shortly after diagnosis of the SMN.
authors.affiliation: Washington University School of Medicine, St. Louis, Missouri.
authors.forename: J J
authors.initials: JJ
authors.lastname: Kovalic
authors.forename: P R
authors.initials: PR
authors.lastname: Thomas
authors.forename: J B
authors.initials: JB
authors.lastname: Beckwith
authors.forename: J H
authors.initials: JH
authors.lastname: Feusner
authors.forename: P A
authors.initials: PA
authors.lastname: Norkool
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000628:therapy; D008113:Liver Neoplasms / Q000209:etiology*; D008297:Male; D009378:Neoplasms, Multiple Primary; D009396:Wilms Tumor / Q000150:complications* / Q000628:therapy