Anti-CD3 antibody-induced lymphocyte proliferation: a new tool for the prenatal diagnosis of some inherited immune deficiencies.
We have compared anti-CD3 monoclonal antibody-induced proliferation of T lymphocytes from normal human fetuses and neonates with that of adult T cells. In contrast to data in the literature, we consistently observed a strong proliferative response during antenatal and perinatal life. A lack of anti-CD3-induced proliferation, despite normal responses to the mitogen phytohemaglutinin, may prove to be a useful criterion in the diagnosis of some ill-defined inherited immune deficiencies.
Le Deist
F
F
INSERM U.132, Hôpital Necker-Enfants Malades, Paris, France.
Durandy
A
A
D000328:Adult; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D017252:CD3 Complex; D005260:Female; D005333:Fetus / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000235:genetics; D007231:Infant, Newborn; D008213:Lymphocyte Activation / Q000276:immunology*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D012306:Risk
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell