Chirality of quartz. Fibrosis and tumour development in dust inoculated mice.
Dextro (d) and laevo (l) forms of quartz dust was inoculated intranasally and subcutaneously into 2-month-old (C57 x BALB/c)F1 mice which were killed 18 months later. Both d and l quartz caused fibrosis, liver nodule formation and an enhanced incidence of lymphoma/leukemia. However, the tumour incidence was significantly higher in l than in d quartz dust-treated animals. It is concluded that in addition to effects clearly independent of chirality there is evidence that the biological response to nonidentical mirror images of solid crystals may differ.
Ebbesen
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Department of Virus and Cancer, Danish Cancer Society, Aarhus C.
D000281:Administration, Intranasal; D000818:Animals; D004391:Dust / Q000009:adverse effects*; D005260:Female; D005355:Fibrosis / Q000209:etiology; D007279:Injections, Subcutaneous; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000209:etiology*; D011791:Quartz / Q000009:adverse effects* / Q000737:chemistry*; D012867:Skin / Q000473:pathology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004391:Dust; D011791:Quartz