title: T cells and asthma. I. Lymphocyte subpopulations and activation in allergic and nonallergic asthma.
abstract: Abnormalities of peripheral-blood lymphocyte subsets and activation markers were detected in patients with both allergic and nonallergic asthma. Most allergic asthmatics were characterized by increased numbers of IL-2R+ helper T cells and CD23+ B cells. In contrast, nonallergic asthmatics showed increased numbers of IL-2R+ and HLA-DR+ helper and cytotoxic T cells, and a clear redistribution from naive (CD45RA+) to memory (CD45RO+) cells. The number of IL-2R+ T cells correlated with the number of CD23+ B cells in allergic asthma. These changes in the distribution and activation state of T cells suggest an active role for T cells in the pathogenesis of both allergic and nonallergic asthma.
authors.affiliation: Schweizerisches Institut für Allergie- und Asthmaforschung, Davos, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Walker
authors.forename: J C
authors.initials: JC
authors.lastname: Virchow
authors.forename: T
authors.initials: T
authors.lastname: Iff
authors.forename: P L
authors.initials: PL
authors.lastname: Bruijnzeel
authors.forename: K
authors.initials: K
authors.lastname: Blaser
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D001249:Asthma / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D017493:Leukocyte Common Antigens; D008213:Lymphocyte Activation; D011961:Receptors, Fc / Q000032:analysis; D017455:Receptors, IgE; D015375:Receptors, Interleukin-2 / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D006684:HLA-DR Antigens; D006649:Histocompatibility Antigens; D011961:Receptors, Fc; D017455:Receptors, IgE; D015375:Receptors, Interleukin-2; D017493:Leukocyte Common Antigens