title: [Effect of hyperosmotic solutions on duodenal motility: a mechanism of resistance or of propulsion to the luminal flow?].
abstract: Infusion of hyperosmotic solutions into the duodenum lead to increased motility. To investigate the mechanism of this effect, 9 healthy volunteers received small infusions of hypertonic (1250 mOsm/kg) NaCl or glucose. Intestinal motility was registered using manometric system with multiple lumens 3 cm apart. Nineteen glucose infusions did not modify intestinal motility. Of 43 NaCl infusions, motility was increased in 24, 7 of them with a typical migratory complex, phase III. In 17 cases, non propagated contractions increasing in a cephalo-caudal direction were noted. The latter may be related to delayed gastric emptying associated to hyperosmotic loads.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad de Chile, Santiago.
authors.forename: C
authors.initials: C
authors.lastname: Defilippi
authors.forename: E
authors.initials: E
authors.lastname: Gómez
authors.forename: J
authors.initials: J
authors.lastname: Chesta
mesh_terms: D000328:Adult; D004386:Duodenum / Q000502:physiology*; D005260:Female; D005746:Gastric Emptying; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D016065:Myoelectric Complex, Migrating; D009994:Osmolar Concentration; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*
chemical_list: D012462:Saline Solution, Hypertonic
vernacular_title: Efecto de soluciones hiperosmóticas en la motilidad duodenal: un mecanismo de resistencia o de propulsión al flujo luminal?