title: Rat cortical sigma receptors differentially regulated by pentazocine and haloperidol.
abstract: Repeated administrations of 7.5 mg/kg of pentazocine (for 14 days) resulted in a significant decrease in the affinity of 3H-haloperidol binding to rat cortical sigma receptors without any changes in the maximal number of binding sites (Bmax). On the other hand, similar treatment with haloperidol (2 or 4 mg/kg) induced a dose dependent decrease in the Bmax values without affecting the affinity of the 3H-haloperidol binding. These findings indicate that rat cortical sigma receptors are differentially regulated by pentazocine and haloperidol.
authors.affiliation: Department of Psychiatry and Neurology, Asahikawa Medical College, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kizu
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Miyagishi
mesh_terms: D000818:Animals; D015536:Down-Regulation / Q000187:drug effects; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009292:Narcotic Antagonists; D010423:Pentazocine / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects*; D017480:Receptors, sigma
chemical_list: D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017480:Receptors, sigma; D006220:Haloperidol; D010423:Pentazocine