Modulative effects of cell adhesion peptide (Arg-Gly-Asp-Ser) on the aggregation of stimulated platelets from ophthalmic patients.
Adhesion proteins are cofactors in the aggregation of human platelets, and can mediate the ADP-induced response of these cells. It was shown that the synthetic cell adhesion peptide, Arg-Gly-Asp-Ser inhibits the aggregation of platelets from normal donors and ophthalmic patients with diabetic retinopathy, glaucoma and retinal vein occlusion. This effect increases in the relative order of activity retinal vein occlusion greater than or equal to glaucoma greater than or equal to diabetic retinopathy greater than control. Deaggregation due to the peptide appeared to be diminished in the order control (normal) greater than diabetic retinopathy greater than glaucoma greater than retinal vein occlusion after its addition at the maximum of aggregation curve. It is concluded that there are differences in the ability of Arg-Gly-Asp-Ser peptide to block the fibronectin adhesion receptor on ADP stimulated platelets from different clinical groups.
Babizhayev
M A
MA
Moscow Helmholtz Research Institute of Eye Diseases, USSR.
Mucha
A I
AI
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D003930:Diabetic Retinopathy / Q000097:blood*; D005260:Female; D005353:Fibronectins / Q000378:metabolism; D005901:Glaucoma / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000494:pharmacology*; D015539:Platelet Activation / Q000187:drug effects / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors; D012170:Retinal Vein Occlusion / Q000097:blood*
D005353:Fibronectins; D009842:Oligopeptides; D010975:Platelet Aggregation Inhibitors; D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic; D000244:Adenosine Diphosphate; C046617:arginyl-glycyl-aspartyl-serine