The initiation site for recombination cog is at the 3' end of the his-3 gene in Neurospora crassa.
Recombination at his-3 in Neurospora crassa is thought to be initiated through a site designated cog which lies in the his-3 to ad-3 interval of linkage group I. Fragments of the his-3 gene were used to transform various his-3 mutant alleles to prototrophy in order to link the genetic map to the nucleotide sequence. It was established that cog is at the 3' end of his-3 and is therefore not the his-3 promoter. This suggests that cog may be dissimilar to a number of yeast recombinators which are associated with promoters of transcription.
Bowring
F J
FJ
School of Biological Sciences, Flinders University, Bedford Park, South Australia.
Catcheside
D E
DE
D000483:Alleles; D005800:Genes, Fungal; D009154:Mutation; D009492:Neurospora crassa / Q000235:genetics*; D010957:Plasmids; D011995:Recombination, Genetic; D015183:Restriction Mapping