Serum lipid and fecal bile acid changes with cereal, vegetable, and sugar-beet fiber feeding.
Thirty-four subjects consumed six controlled formula diets for 3 wk each, supplemented with 0 g added fiber, 10 and 30 g dietary fiber as wheat bran (WB), 10 and 30 g dietary fiber as mixed vegetable fiber (VF), and 30 g dietary fiber as sugar-beet fiber (SBF). Serum cholesterol changes for fiber free, 10 g WB, 30 g WB, 10 g VF, 30 g VF, and 30 g SBF (-0.13, -0.18, -0.05, -0.17, -0.24, and -0.70 mmol/L, respectively) were significant for 30 g VF and 30 g SBF. Reduction in total cholesterol with SBF was largely due to significant lowering of low-density-lipoprotein cholesterol. Total fecal bile acid concentrations were significantly higher with the fiber-free diet than with 30 g WB, VF, and SBF (P less than 0.001) and were also higher with 30 g SBF than with 30 g WB and 30 g VF (P less than 0.005). Daily fecal bile acid excretion was not different on 30 g SBF compared with 30 g WB and 30 g VF. Differences in cholesterol reduction across the diets could not be explained by differences in fecal bile acid excretion.
Lampe
J W
JW
Department of Food Science and Nutrition, University of Minnesota, St Paul 55108.
Slavin
J L
JL
Baglien
K S
KS
Thompson
W O
WO
Duane
W C
WC
Zavoral
J H
JH
D000328:Adult; D000704:Analysis of Variance; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D001647:Bile Acids and Salts / Q000032:analysis*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004043:Dietary Fiber / Q000494:pharmacology*; D002523:Edible Grain; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D011897:Random Allocation; D012995:Solubility; D014280:Triglycerides / Q000097:blood; D014675:Vegetables
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D001647:Bile Acids and Salts; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol