[Features of adrenal cortex function in heterozygous carriers of 21-hydroxylase deficiency].
Adrenocortical function in carriers of 21-hydroxylase insufficiency and in persons without it was investigated by change in the levels of 17-hydroxyprogesterone and dehydroepiandrosterone before and against a background of prolonged ACTH stimulation. Differences in change of the basal concentrations of these hormones in both groups were absent. Change of adrenocortical function in the carriers was observed against a background of ACTH stimulation only by the blood level of 17-hydroxyprogesterone. Prolonged ACTH stimulation revealed not only quantitative but also qualitative traits of adrenocortical function in carriers of 21-hydroxylase insufficiency. An algorithm for diagnosing this insufficiency was worked out.
Dzenis
I G
IG
Brykova
E K
EK
Gertts
G
G
Korsakov
S G
SG
D019326:17-alpha-Hydroxyprogesterone; D000302:Adrenal Cortex / Q000503:physiopathology*; D000312:Adrenal Hyperplasia, Congenital / Q000235:genetics*; D000324:Adrenocorticotropic Hormone; D000465:Algorithms; D003687:Dehydroepiandrosterone / Q000097:blood; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006908:Hydroxyprogesterones / Q000097:blood; D008297:Male
D006908:Hydroxyprogesterones; D003687:Dehydroepiandrosterone; D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
Osobennosti funktsii kory nadpochechnikov u geterozigotnykh nositeleĭ nedostatochnosti 21-gidroksilazy.