Dystrophic mineralisation in cerebrum of aging mice.
The incidence of cerebral dystrophic mineralisation in CD-1 mice (Charles River bred, cesarean-derived) obtained from long term studies over a 10 year period is reported. The survey included brain samples from 15869 males and 15729 females. The incidence of cerebral dystrophic mineralisation is 0.6% in untreated males and 0.3% in untreated females. The total incidence in all mice in the survey showed higher incidence in males than females and was age-related. The present survey also showed interstrain differences. The mineralisation in CD-1 strain was low in incidence and B6C3Fl (cross between C57BL/C6 NCR LB and C3H/HEN NCR LB, bred by Charles River) with relatively high incidence. The foci of mineralisation was dystrophic and probably of neuronal origin in this survey.
Majeed
S K
SK
Huntingdon Research Centre Ltd., Pathology Department, Cambridgeshire, England.
D000375:Aging / Q000502:physiology*; D000818:Animals; D001927:Brain Diseases / Q000473:pathology*; D002114:Calcinosis / Q000473:pathology*; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D012727:Sex Characteristics
D006025:Glycosaminoglycans