Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion.
Mithramycin (MTR) is an antitumor compound that inhibits RNA and DNA polymerase action by forming a non covalent complex with double strand DNA, in the presence of divalent cations. We have shown that in the presence of Mg2+, MTR binds to right-handed poly(dG-m5dC) as a dimer in the right-handed screwness conformation but cannot bind to left-handed poly(dG-m5dC).
Demicheli
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Laboratoire de Chimie Bioinorganique, LPCB (UA CNRS 198), UFR Biomédicale, Bobigny, France.
Garnier-Suillerot
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A
D002118:Calcium; D002413:Cations, Divalent; D002942:Circular Dichroism; D007700:Kinetics; D008274:Magnesium; D008968:Molecular Conformation; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D008926:Plicamycin / Q000737:chemistry*; D011089:Polydeoxyribonucleotides / Q000737:chemistry*
D002413:Cations, Divalent; D011089:Polydeoxyribonucleotides; C016681:poly(dG).poly(dC); C029988:poly(dG-m(5)dC).poly(dG-m(5)dC); D008274:Magnesium; D008926:Plicamycin; D002118:Calcium