title: Effect of denervation on the neurogenic inflammation of the rat mandibular mucosa.
abstract: Effects of local exposure to capsaicin on the vascular permeability and blood flow were studied in the rat oral mucosa at days 2 and 14 after the unilateral transection of the inferior alveolar nerve (IAN). The distribution of nerve fibers displaying substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactivity (IR) in the mandibular mucosa was also assessed. While the capsaicin-induced augmentation in vascular permeability was about 50% (P less than 0.05) higher on the intact side (at both days 2 and 14) than on the denervated side, no difference in blood flow elevation was seen between the two sides. Transection of IAN caused only a slight reduction in the density of SP- and CGRP-IR fibers in the mucosa. It is concluded that in addition to the IAN fibers the mandibular mucosa examined also seems to be supplied by other sensory fibers. The presence of accessory trigeminal branches was also supported by immunohistochemical studies.
authors.affiliation: Department of Conservative Dentistry, Semmelweis University of Medicine, Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Fazekas
authors.forename: A
authors.initials: A
authors.lastname: Györfi
authors.forename: E
authors.initials: E
authors.lastname: Pósch
authors.forename: G
authors.initials: G
authors.lastname: Jakab
authors.forename: Z
authors.initials: Z
authors.lastname: Bártfai
authors.forename: L
authors.initials: L
authors.lastname: Rosivall
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000302:isolation & purification; D002199:Capillary Permeability / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D008334:Mandible / Q000098:blood supply / Q000187:drug effects* / Q000294:innervation; D009092:Mucous Membrane / Q000098:blood supply / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013562:Sympathectomy
chemical_list: D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin