Effect of thymic extract on allogeneic MLR and mitogen-induced responses in patients with chronic active hepatitis B.
Cell-mediated immune reactions are involved in the development of chronic active hepatitis (CAH-B). The present studies confirm that lymphocyte from patients with CAH-B have a decreased allogeneic mixed lymphocyte reaction (allo-MLR) and mitogen-induced responses. These abnormalities probably play a role in the immunological dysfunctions underlying chronic liver diseases. Twenty one patients with biopsy-proven CAH-B and a significantly lowered CD4:CD8 cell number ratio were treated with thymic extract (Thymomodulin-TFX) for 6 months. The results of immunological, serological and biochemical findings indicate that this preparation has an immunoregulatory action and produces beneficial clinical effect in patients with CAH-B.
Zeman
K
K
Department of Pathophysiology & Immunology, Military Medical Academy, Lódz, Poland.
Dworniak
D
D
Tchórzewski
H
H
Pokoca
L
L
Majewska
E
E
D000328:Adult; D000911:Antibodies, Monoclonal; D016516:CD4-CD8 Ratio; D006509:Hepatitis B / Q000276:immunology / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007111:Immunity, Cellular; D016130:Immunophenotyping; D008213:Lymphocyte Activation / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D008934:Mitogens; D013601:T-Lymphocytes / Q000276:immunology; D013949:Thymus Extracts / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D008934:Mitogens; D013949:Thymus Extracts; C051006:thymomodulin