Testis-determining factor and Y-linked sex reversal.
A gene named SRY, isolated last year from the sex-determining region of the human Y chromosome, satisfies many of the criteria expected of the testis-determining factor gene. Mutations in SRY have been found in XY females, strongly implicating SRY as the testis-determining gene.
Hawkins
J R
JR
Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, London, UK.
Koopman
P
P
Berta
P
P
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D012734:Disorders of Sex Development; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D008297:Male; D051379:Mice / Q000235:genetics; D009154:Mutation; D009687:Nuclear Proteins; D012732:Sex Determination Analysis; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors; D014998:Y Chromosome
D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D009687:Nuclear Proteins; C497745:SRY protein, human; D051876:Sex-Determining Region Y Protein; C497746:Sry protein, mouse; D014157:Transcription Factors; C054430:ZFY protein, human; C062076:zinc finger protein, X-linked