[Clinical study of combination chemotherapy with cisplatin, ifosfamide, 5-FU (CIF therapy) of inoperable adenocarcinoma and large cell carcinoma of the lung].
Forty seven patients with inoperable adenocarcinoma and large cell carcinoma of the lung were treated with a combination of cisplatin (25 mg/m2), ifosfamide (1.5 g/m2), 5-FU (1.0 g/m2 c.i.) on day 1 through 4. The overall response rate (PR) was 34.8% with 16 partial responses. The median duration of response was 81 days. The median duration to show 50% decrease was 27 days. The median survival time was 359 days for all evaluable patients and 555 days for responders versus 196 days for non-responders. The side effects were mild and tolerable. The response rate of CIF therapy was same as the one reported in recent years but the survival time for responders was long and side effects were mild, suggesting that CIF therapy is an effective chemotherapy.
Fujita
A
A
Division of Respiratory Diseases, Minamiichijo Hospital, Sapporo, Japan.
Sasaki
H
H
Mori
T
T
Nakajima
S
S
Sekine
K
K
Inoue
Y
Y
Honda
R
R
Asakawa
M
M
Suzuki
A
A
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality; D002945:Cisplatin / Q000008:administration & dosage; D004341:Drug Evaluation; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D015996:Survival Rate
D002945:Cisplatin; D005472:Fluorouracil; D007069:Ifosfamide