[Different effects on dopamine receptors D1 and D2 following long-term usage of L-dopa].
Different effects on D1 and D2 receptor subtypes were studied through observation of animal behavior, striatal receptor binding, and micro-electrode recording of cell activity in substantia nigra pars compacta of rats. The authors investigated the relation between dynamic changes of D1 and D2 receptor subtypes and the animal behavior, and speculate on the possible mechanisms of deterioration of drug effect and appearance of AIM induced by DA agonists during the treatment of Parkinson's disease.
Wei
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Dept of Neurology, Ren-jiHospital, Shanghai 2 Medical University.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001599:Berberine / Q000031:analogs & derivatives / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000502:physiology
D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D001599:Berberine; C010513:stepholidine; D007980:Levodopa