NMDA receptor antagonists block the induction of long-term depression in the hippocampal dentate gyrus of the anesthetized rat.
The present study tested the effect of two non-competitive NMDA receptor antagonists, ketamine and phencyclidine, on the induction of long-term depression (LTD) in the dentate gyrus of urethane-anesthetized rats. Both drugs blocked the induction of LTD as well as long-term potentiation (LTP). NMDA receptor activation thus seems to be required for the induction of both LTD and LTP in the dentate gyrus. High-intensity conditioning stimulation did not overcome the phencyclidine block of LTD. Strong, but brief, postsynaptic depolarization is apparently not the only event needed to trigger LTD.
Desmond
N L
NL
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.
Colbert
C M
CM
Zhang
D X
DX
Levy
W B
WB
D000768:Anesthesia, General; D000818:Animals; D001369:Axons / Q000502:physiology; D004558:Electric Stimulation / Q000379:methods; D007839:Functional Laterality; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine; D010622:Phencyclidine