[Captopril-induced changes in renal flow: evaluation using Doppler echography].
It is well known that angiotensin antagonists cause increase of renal blood flow. We have examined, using duplex Doppler sonography, the changes of renal blood flow velocity induced by oral administration of 50 mg. of Captopril. We examined 19 kidneys in 17 subjects without hypertension. Both peak systolic and diastolic velocities were measured at renal hilum and at arcuate arteries, and the resistive index (RI) was calculated. In conclusion duplex Doppler sonography shows significant increase of blood flow velocities both at the hilum and at the arcuate arteries, without variation of the RI, thus showing that changes affect the whole Doppler wave, both in systole and diastole.
Pretolesi
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F
Istituto di Radiologia, Università di Genova.
Derchi
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LE
Crespi
G
G
Biggi
E
E
Saffioti
S
S
Pontremoli
R
R
D001783:Blood Flow Velocity / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D003971:Diastole; D006801:Humans; D011877:Radionuclide Imaging; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012079:Renal Circulation / Q000187:drug effects*; D013599:Systole; D016284:Technetium Tc 99m Pentetate; D014463:Ultrasonography; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D002216:Captopril; D016284:Technetium Tc 99m Pentetate
Variazioni del flusso renale indotte da captopril: valutazione mediante eco Doppler.