A possible new approach to the problem of refractory peptic ulceration. A role for free radical scavengers?
Refractory peptic ulceration refers to those gastric and duodenal ulcers that are slow to heal despite active treatment. Oxygen-derived free radicals are cytotoxic and promote tissue injury. This report shows that radical scavengers stimulate the healing of refractory peptic ulceration, thus, providing a valuable method for the treatment of such ulceration.
Salim
A S
AS
Department of Surgery, Royal Infirmary, Perth, UK.
D000328:Adult; D000493:Allopurinol / Q000627:therapeutic use*; D002908:Chronic Disease; D002927:Cimetidine / Q000627:therapeutic use; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D016166:Free Radical Scavengers; D005609:Free Radicals; D006801:Humans; D006878:Hydroxides / Q000009:adverse effects; D017665:Hydroxyl Radical; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology
D016166:Free Radical Scavengers; D005609:Free Radicals; D006878:Hydroxides; D017665:Hydroxyl Radical; D000493:Allopurinol; D002927:Cimetidine; D004121:Dimethyl Sulfoxide