title: Investigation of the mechanisms of platelet activation mediated through adrenoceptors.
abstract: ADP induced membrane reorganization leading to an increase in membrane microviscosity with the decrease in the distance between protein globules and membrane surface. Adrenaline at low concentrations enhanced the ADP-induced platelet aggregation and deepened the structural reorganization. Analogous phenomenon was induced by the selective alpha 2-adrenoceptor agonist azopexole. The selective alpha 2-adrenoceptor antagonist idazoxan eliminated the effects of both adrenaline and azopexole. It is suggested that alpha 2-adrenoceptor activation leads to an increase in the number of fibrinogen receptors on platelet membranes due to the more pronounced advancement of membrane proteins to the membrane surface.
authors.affiliation: Department of Pharmacology, Erevan Medical Institute, Armenia, USSR.
authors.forename: E S
authors.initials: ES
authors.lastname: Gabrielian
authors.forename: S E
authors.initials: SE
authors.lastname: Akopov
authors.forename: A G
authors.initials: AG
authors.lastname: Ayvasian
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D002462:Cell Membrane / Q000502:physiology; D004837:Epinephrine / Q000494:pharmacology; D005454:Fluorescence Polarization; D006801:Humans; D066298:In Vitro Techniques; D008560:Membrane Fluidity / Q000187:drug effects; D015539:Platelet Activation / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects; D011941:Receptors, Adrenergic / Q000502:physiology*; D014783:Viscosity
chemical_list: D011941:Receptors, Adrenergic; D000244:Adenosine Diphosphate; D004837:Epinephrine