New neplanocin analogues. Synthesis and antiviral activity of 6'-modified neplanocin A derivatives.
Novel neplanocin A analogues modified at the 6'-position, i.e. 6'-deoxy derivatives (2, 3, 5, 6, 14), 6'-O-methylneplanocin A (10) and 6'-C-methylneplanocin A (16a and 16b) were synthesized and evaluated for their antiviral activity in a wide variety of virus systems. Compound 16a (TJ-13025) surpassed neplanocin A both in antiviral potency and selectivity.
Shuto
S
S
Exploratory Research Laboratory, Toyo Jozo Co., Ltd, Shizuoka, Japan.
Obara
T
T
De Clercq
E
E
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D010084:Oxidation-Reduction
D000998:Antiviral Agents; C031096:neplanocin A; D000241:Adenosine