title: Astrocytes: a possible primary site for colchicine-mediated neurotoxicity in the rat striatum.
abstract: Ultrastructural changes in rat astrocytes including endfoot swelling and rupture of plasma membranes were seen as early as 1 h after injection of 6.0 micrograms colchicine (CO) into the striatum. Significant change in neuronal morphology was not seen by 24 h. Astrocytes may therefore be primary targets for CO-mediated damage, which then may have secondary neurotoxic consequences.
authors.affiliation: Ensor Laboratory, William S. Hall Psychiatric Institute, Columbia, South Carolina 29202.
authors.forename: O M
authors.initials: OM
authors.lastname: Pitts
authors.forename: M R
authors.initials: MR
authors.lastname: Cohen
authors.forename: W
authors.initials: W
authors.lastname: McAmis
authors.forename: R L
authors.initials: RL
authors.lastname: Gutman
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000648:ultrastructure; D003078:Colchicine / Q000633:toxicity*; D003342:Corpus Striatum / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003078:Colchicine