title: [Long-term effects of splenectomy for immune thrombopenic purpura related to human immunodeficiency virus. A retrospective study from 2 groups, with and without splenectomy].
abstract: In order to evaluate the long-term effects of splenectomy in patients with human immunodeficiency virus-related immune thrombocytopenic purpura (ITP), we studied retrospectively two populations of patients: 21 had undergone splenectomy and 18 had not. At the time of diagnosis the first population had on average lower platelet counts than the second one. After a mean follow-up of 47 +/- 9 months the situation has been reversed: the population that underwent splenectomy had significantly higher platelet counts than that without splenectomy (190.600 +/- 55.300/mm3 versus 91.500 +/- 55.300/mm3, P less than 0.001). Moreover 76 percent of the patients with splenectomy versus 50 percent in the population without splenectomy were in complete remission of ITP at the last follow-up. It therefore seems that splenectomy had a statistically positive effect on platelet counts without worsening the immune status. Indeed, the clinical course towards AIDS was the same in both populations (35 percent in patients with splenectomy and 22 percent without, P = NS). Following splenectomy, the total blood lymphocytes count was increased, especially the CD8 population, while the CD4 count remains unchanged; these findings seem to be a common feature after splenectomy.
authors.affiliation: Service d'Hématologie, Hôpital Pitié-Salpêtrière, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Gabarre
authors.forename: N
authors.initials: N
authors.lastname: Azar
authors.forename: T
authors.initials: T
authors.lastname: Ben Othman
authors.forename: S
authors.initials: S
authors.lastname: Gharakhanian
authors.forename: R
authors.initials: R
authors.lastname: De Sahb
authors.forename: E
authors.initials: E
authors.lastname: Dohin
authors.forename: P
authors.initials: P
authors.lastname: Sansonetti
authors.forename: P
authors.initials: P
authors.lastname: Langlois
authors.forename: J P
authors.initials: JP
authors.lastname: Chigot
authors.forename: M
authors.initials: M
authors.lastname: Echard
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000150:complications; D006801:Humans; D007958:Leukocyte Count; D016131:Lymphocyte Subsets; D008214:Lymphocytes; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000209:etiology / Q000601:surgery*; D012189:Retrospective Studies; D013156:Splenectomy; D013997:Time Factors
vernacular_title: Effets à long terme de la splénectomie pour purpura thrombopénique immunologique lié au virus de l'immunodéficience humaine. Etude rétrospective à partir de deux groupes, avec et sans splénectomie.