[Transient subendocardial ischemia in abolition of hypertensive crises with nifedipine].
Sublingual nifedipine, 30 mg, was used to abolish hypertensive crises in 32 patients. A follow-up of changes in blood pressure, ECG, and echocardiographic parameters evaluating the cardiac performance and central hemodynamics was performed during 4 hours after the drug. The patients with profound myocardial hypertrophy and dilatation at a left ventricular myocardial weight of over 200 g at the peak of the antihypertensive effect occurred for 15-60 min exhibited transient ECG changes by the type of subendocardial ischemia despite an above 25% reduction in mean blood pressure and the lack of severe reflex tachycardia, the pump function of the heart showing no decreases. The ejection fraction increased from 51.0 +/- 2.8 to 62.0 +/- 2.5% (p less than 0.05) due to lower afterload. There were no clinical manifestations typical of myocardial ischemia.
Ivleva
A Ia
AIa
Kobalava ZsD
Demidenko
I V
IV
Krasnobaeva
G M
GM
Strugovshchikov
A N
AN
Moĭseev
V S
VS
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000209:etiology / Q000503:physiopathology*; D003327:Coronary Disease / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D004452:Echocardiography / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects* / Q000627:therapeutic use
D009543:Nifedipine
Tranzitornaia subéndokardial'naia ishemiia miokarda pri kupirovanii gipertonicheskikh krizov nifedipinom.