[Effects of thiopental and propofol on suppressor T lymphocyte activity and noradrenaline release].
The effects of thiopental and propofol on lymphocyte suppressor T activity were studied in the basal state and after 20 min, 24 hours, and 4 days of anesthesia induction in 20 patients undergoing gynaecologic surgery. Both drugs induced a decrease in lymphocyte suppressive T activity which recovered after 4 days and tended to be larger, although not significantly, with thiopental. Serum noradrenaline concentration significantly increased after two hours of propofol anesthesia and after 20 min and 2 hours of thiopental administration. These results demonstrate that the relationship between lymphocyte suppressive T activity and noradrenaline corresponds theoretically to anesthesia deepness.
Muriel Villoria
C
C
Hospital Clínico Universitario de Salamanca.
Zaballos Aguado
A
A
Sánchez Barrado
E
E
Santos Lamas
J
J
Vicente Villardón
J L
JL
D005260:Female; D006801:Humans; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism*; D015742:Propofol / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*; D013874:Thiopental / Q000494:pharmacology*; D013997:Time Factors
D013874:Thiopental; D009638:Norepinephrine; D015742:Propofol
Efectos del tiopental y el propofol sobre la actividad T supresora linfocitaria y la liberación de noradrenalina.