title: Radiolabelled granulocytes in inflammatory bone disease.
abstract: Inflammatory lesions in 7 patients have been investigated using labelled in vivo granulocytes. Targeting of white cells was done with a monoclonal antibody, mouse IgG1 reacting with NCA (non-specific crossreacting antigen) and CEA (carcinoembryonic antigen) (BW 250/183) labelled with 99mTc. All inflammatory lesions were visualized, with excellent quality scintigram, between 3-6 and 24 h after the injection. Because the antibody can be stored in a freeze-dried form and labelled at any time with 99mTc without cell separation being necessary, the method appears to be suitable even for use in acute diagnosis.
authors.affiliation: Department of Nuclear Medicine, University of Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: D'Amico
authors.forename: S
authors.initials: S
authors.lastname: Lastoria
authors.forename: N
authors.initials: N
authors.lastname: Caccavella
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
mesh_terms: D000911:Antibodies, Monoclonal; D001170:Arthritis, Infectious / Q000000981:diagnostic imaging* / Q000276:immunology; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D010019:Osteomyelitis / Q000000981:diagnostic imaging* / Q000276:immunology; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m
chemical_list: D000911:Antibodies, Monoclonal; D013670:Sodium Pertechnetate Tc 99m