Contraceptive efficacy of Depot Provera jet-injected into the cervix.
Depot-medroxy progesterone acetate (DMPA) was jet deposited into the uterus/cervix of rats, rabbits and rhesus monkeys with the help of a modified jet injection apparatus. Since the drug was delivered under pressure, it was distributed deep into the muscular layers around the place of deposition. After one deposition the drug acted as an effective contraceptive for a period of three months. The merits of this delivery technique are discussed.
Riar
S S
SS
Defence Institute of Physiology & Allied Sciences, Delhi Cantt.
Sawhney
R C
RC
Thomas
P
P
Bardhan
J
J
Kain
A K
AK
Singh
T
T
D000818:Animals; D002584:Cervix Uteri; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007277:Injections, Jet; D007986:Luteinizing Hormone / Q000097:blood; D008253:Macaca mulatta; D008297:Male; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011817:Rabbits; D051381:Rats
D003271:Contraceptive Agents, Female; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone