[Protective effect of tannic acid against TPA- and cigarette smoke condensate-induced DNA strand breaks in human white cells and its antioxidant action].
Tannic acid was extracted from Rhus chinensis Mill. At a concentration of 50 micrograms/ml it could significantly prevent the DNA damaging effects induced by TPA (100 ng/ml) or cigarette smoke condensate (400 micrograms/ml). At concentrations of 5 micrograms/ml and 80 micrograms/ml, it could effectively scavenge the O2-. produced by VB2 + hv and cigarette smoke condensate, respectively. The lipid peroxidation of red cell membrane induced by H2O2 was decreased significantly by tannic acid at a concentration of 5 micrograms/ml.
Fu
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Institute of Oncology, Beijing.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D047348:Hydrolyzable Tannins / Q000008:administration & dosage / Q000494:pharmacology*; D007962:Leukocytes; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D010947:Plants, Toxic; D012906:Smoke / Q000009:adverse effects*; D013755:Tetradecanoylphorbol Acetate; D014026:Nicotiana
D000975:Antioxidants; D047348:Hydrolyzable Tannins; D012906:Smoke; D013755:Tetradecanoylphorbol Acetate