Evidence for the secretion of inhibin-like immunoreactivity from cultured human adrenal cells.
We have studied the production and release of inhibin-like immunoreactivity in the human adrenal gland. Extract of human adrenal glands showed a displacement curve paralleled with the inhibin standard. Inhibin-like immunoreactivity contents in the adrenal gland was 1893 +/- 474 (mean +/- S.D.) IU/g wet weight tissue. ACTH stimulated the secretion of inhibin-like immunoreactivity as well as cortisol and aldosterone in a dose-dependent manner in the cultured adrenal cells. These results indicate that the human adrenal gland produces and secretes inhibin-like peptide in response to ACTH.
Haji
M
M
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Nishi
Y
Y
Tanaka
S
S
Ohashi
M
M
Sekiya
K
K
Hasegawa
Y
Y
Igarashi
M
M
Sasamoto
S
S
Nawata
H
H
D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000378:metabolism; D000937:Antigen-Antibody Reactions; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007265:Inhibins / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D000450:Aldosterone; D007265:Inhibins; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone