5-HT receptor-mediated regulation of thyrotropin-releasing hormone release in rat spinal cord.
5-Hydroxytryptamine (5-HT, 10 microM) increased the veratridine-evoked release of thyrotropin-releasing hormone (TRH) from spinal cord slices. This effect of 5-HT was reduced by pre-exposure of the tissue to 10 microM ketanserin and methysergide, which both have 5-HT2 antagonistic activity. A 5-HT1 agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (10 microM), reduced the release of TRH. These results imply that 5-HT released from the terminals of descending fibers modulates the release of TRH, a cotransmitter contained in 5-HT fibers.
Ono
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Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Ono
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Fukuda
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D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D008297:Male; D010869:Pindolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D013116:Spinal Cord / Q000378:metabolism*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*; D014701:Veratridine / Q000494:pharmacology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013764:Tetrahydronaphthalenes; D012701:Serotonin; D013973:Thyrotropin-Releasing Hormone; D014701:Veratridine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D010869:Pindolol