[Effects of atrial natriuretic peptide AP II on proliferation processes in the epithelial tissue of white rats].
The effect of atrial natriuretic peptides synthetic analog AP II on corneal, skin, tongue and duodenum epithelium proliferation have been studied on male rats. The epithelium mitotic activity and DNA synthesis were evaluated in 4 and 24 h after intraperitoneal injection of 10 or 100 micrograms/kg AP II. 10 micrograms/kg AP II was found to have different influence on organs epithelium: it decreased the mitotic activity of skin and corneal epithelium, but activated the proliferation processes in tongue and duodenum epithelium. 100 micrograms/kg AP II stimulated cell mitogenesis in all organs studied. According to data obtained atrial natriuretic peptides are able to participate in cell division regulation in vivo.
Timoshin
S S
SS
Goncharova
E N
EN
Radivoz
M I
MI
Bespalova
Zh D
ZhD
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D003315:Cornea; D004247:DNA / Q000096:biosynthesis; D004386:Duodenum; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects*; D008297:Male; D051381:Rats; D012867:Skin; D014059:Tongue
D009320:Atrial Natriuretic Factor; D004247:DNA
Vliianie predserdnogo natriĭureticheskogo peptida AP II na protsessy proliferatsii v épitelial'noĭ tkani belykh krys.