Assignment of beta-hexosaminidase A alpha-subunit to human chromosomal region 15q23----q24.
Tay-Sachs disease results from a mutation in the alpha subunit of beta-hexosaminidase. Using a cDNA clone, we have mapped the gene to 15q23----q24 by in situ hybridization.
Nakai
H
H
Department of Human Genetics, Rosewell Park Memorial Institute, Buffalo, NY 14263.
Byers
M G
MG
Nowak
N J
NJ
Shows
T B
TB
D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15 / Q000648:ultrastructure*; D015342:DNA Probes; D005796:Genes; D006801:Humans; D009693:Nucleic Acid Hybridization; D013661:Tay-Sachs Disease / Q000235:genetics*; D001619:beta-N-Acetylhexosaminidases / Q000235:genetics*
D015342:DNA Probes; D001619:beta-N-Acetylhexosaminidases