Binding of antagonists of H1 and H2 histamine receptors to peripheral blood lymphocytes of atopic and healthy subjects.
The binding of the antagonists of histamine H1 and H2 receptors by peripheral blood lymphocytes from atopic and healthy subjects was investigated. We found that lymphocytes from atopic subjects showed statistically significant decrease in the binding of H2 receptor antagonist - ranitidine. In addition, lymphocytes from atopic and control subjects had similar capacity of binding of H1 receptor antagonist - promethazine. The ratio of the amount of H1 and H2 antagonists, bound to lymphocytes from atopic and healthy subjects, was calculated. The difference between the values in the group of atopic (2.55) and control subjects (1.55) was statistically significant.
Zak-Nejmark
T
T
Department of Internal Diseases, Medical Academy, Wrocław.
Małolepszy
J
J
Osos
M
M
Nadobna
G
G
Jutel
M
M
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011398:Promethazine / Q000378:metabolism*; D011899:Ranitidine / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D011899:Ranitidine; D011398:Promethazine