title: Incidence of hepatitis and seroconversion to hepatitis C virus after open-heart surgery in transfused and non-transfused patients in Sweden.
abstract: The transmission of non-A, non-B hepatitis (NANB)/hepatitis C virus (HCV) was studied in patients undergoing open-heart surgery and related to the reception of blood products and hospitalization and surgery per se. Posttransfusion hepatitis NANB was noticed in 17/390 (4.4%) patients receiving heterologous blood and 8/16 tested became positive for anti-HCV (Ortho HCV ELISA), all within 5 months after onset of hepatitis. Among patients with normal ALAT before surgery and during follow-up, who had received heterologous blood, 1/50 seroconverted after 6 months. This patient probably had a subclinical HCV infection, or possibly a temporary non-specific anti-HCV reactivity with a maximum optical density/cut-off ratio (OD/CO) of 1.2, whereas all posttransfusion hepatitis C cases had OD/CO ratios greater than 4. No hepatitis occurred among the 92 non-transfused patients and no seroconversion was found in any of 62 non-transfused patients tested 6 months after the operation. It was concluded that (1) hospitalization and surgery per se does not seem to offer a risk of hepatitis NANB/C, and (2) seroconversion to for HCV occurs in only 50% of Swedish patients with acute posttransfusion NANB hepatitis.
authors.affiliation: Department of Infectious Diseases, Roslagstull Hospital, Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Mattsson
authors.forename: B
authors.initials: B
authors.lastname: Aberg
authors.forename: M
authors.initials: M
authors.lastname: von Sydow
authors.forename: O
authors.initials: O
authors.lastname: Weiland
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001803:Blood Transfusion; D006348:Cardiac Surgical Procedures; D005500:Follow-Up Studies; D016174:Hepacivirus / Q000276:immunology; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D015994:Incidence; D008099:Liver / Q000201:enzymology; D011446:Prospective Studies; D012189:Retrospective Studies; D013548:Sweden / Q000453:epidemiology
chemical_list: D006508:Hepatitis Antibodies; D000410:Alanine Transaminase