Effects of buthobendin and epinephrine on glycolytic energy formation and magnesium concentration in vitro and in vivo.
Buthobendin activated glycolytic lactate formation stronger than epinephrine and increased the ATP level, both in vitro in rabbit myocardial slices and in vivo in rabbit blood. These effects were accompanied by an increase in extracellular magnesium concentration, which was probably related to the inhibitory effect of buthobendin on the membrane-bound ATPases.
Gumińska
M
M
Institute of Medical Biochemistry, Copernicus Medical Academy, Kraków, Poland.
Kedryna
T
T
Marchut
E
E
Stachurska
M
M
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005029:Ethylenediamines / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects*; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D011817:Rabbits
D005029:Ethylenediamines; D007773:Lactates; C030706:butobendin; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D008274:Magnesium; D004837:Epinephrine