title: Molecular structure of the Japanese hepatitis C viral genome.
abstract: The amino acid sequence of the polyprotein deduced from the nucleotide sequence of the Japanese hepatitis C virus genome (N. Kato et al. (1990) Proc. Natl. Acad. Sci. USA 87, 9524-9528) indicated that this virus is a member of a new class of positive-stranded RNA viruses. Several domains of this polyprotein also showed weak homology with those of flaviviruses and pestiviruses including the chymotrypsin-like serine proteinase, NTPase and RNA-dependent RNA polymerase.
authors.affiliation: Virology Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Hijikata
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ootsuyama
authors.forename: K
authors.initials: K
authors.lastname: Muraiso
authors.forename: S
authors.initials: S
authors.lastname: Ohkoshi
authors.forename: K
authors.initials: K
authors.lastname: Shimotohno
mesh_terms: D000595:Amino Acid Sequence; D002918:Chymotrypsin / Q000737:chemistry / Q000235:genetics; D005416:Flavivirus / Q000235:genetics; D016174:Hepacivirus / Q000235:genetics*; D008969:Molecular Sequence Data; D043583:Nucleoside-Triphosphatase; D010576:Pestivirus / Q000235:genetics; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry / Q000235:genetics; D012324:RNA-Dependent RNA Polymerase / Q000737:chemistry / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D012995:Solubility; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics*
chemical_list: D014764:Viral Proteins; D012324:RNA-Dependent RNA Polymerase; D010744:Phosphoric Monoester Hydrolases; D002918:Chymotrypsin; D043583:Nucleoside-Triphosphatase