[Elevation of 11-dehydro-thromboxane B2 levels in unstable angina].
To evaluate in vivo platelet activation, 11-dehydro-thromboxane B2 levels in plasma and urine were measured in 9 patients with unstable angina and 11 with stable angina using radioimmunoassay modified by the extraction method of Kawano et al. The 2 groups were matched for age, sex, coronary risk factors, medications or atherosclerotic lesions in coronary angiography. Although there was no difference in the plasma level between the 2 groups in the usual state, urinary 11-dehydro-thromboxane B2 amount in unstable angina was significantly increased compared to the stable angina group (865.5 +/- 238.7 vs 535.9 +/- 177.4 pg/mg creatinine (mean +/- SD), p < 0.01). There was no correlation between the 11-dehydro-thromboxane B2 level and the degree of coronary atherosclerosis in either group. The plasma level increased during the attacks in 2 patients with unstable angina. The amount of urinary 6-keto-PGF1 alpha did not differ between the 2 groups. These findings suggest that platelet activation in vivo is more pronounced in unstable angina than in stable angina, and that the measurement of urinary 11-dehydro-thromboxane B2 may be useful for evaluating and treating angina.
Koike
T
T
First Department of Internal Medicine, Niigata University School of Medicine.
Hattori
A
A
Igarashi
Y
Y
Matsubara
T
T
Tamura
Y
Y
Yamazoe
M
M
Izumi
T
T
Shibata
A
A
D000787:Angina Pectoris / Q000378:metabolism; D000789:Angina, Unstable / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003324:Coronary Artery Disease / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013929:Thromboxane B2 / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000652:urine
D013929:Thromboxane B2; C049235:11-dehydro-thromboxane B2