title: Genetic epidemiology of Down's syndrome in Shetland.
abstract: Pedigrees of all known cases, on Shetland, of Down's syndrome, cytogenetically confirmed as trisomy 21, and of a control for each patient matched by birth date, sex and birth place, were traced over a minimum of eight generations. Mean kinship coefficients in all pairs of Down's syndrome patients and in all pairs of controls were similar. The kinship between the father and mother of each case shows that the parents are more closely related than the general level of relationship in the population, suggesting some recessive element in the etiology. It is argued that the effect of the resulting increased homozygosity would be to prevent the loss of the conceptus that occurs in the majority of trisomy 21 conceptions.
authors.affiliation: Department of Human Genetics, University of Newcastle upon Tyne, UK.
authors.forename: D F
authors.initials: DF
authors.lastname: Roberts
authors.forename: M J
authors.initials: MJ
authors.lastname: Roberts
authors.forename: A W
authors.initials: AW
authors.lastname: Johnston
mesh_terms: D000328:Adult; D004314:Down Syndrome / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006801:Humans; D007178:Inbreeding; D008297:Male; D008875:Middle Aged; D006113:United Kingdom / Q000453:epidemiology