Local tissue reaction to intravenous fluorouracil and leucovorin.
Fluorouracil alone can cause a variety of dermatologic adverse effects; however, it is not considered to be a chemical vesicant. We report a case of apparent enhanced local skin reaction from the combination of intravenous fluorouracil and leucovorin. The reaction occurred in the patient's other hand on rechallenge.
Umstead
G S
GS
Department of Pharmaceutical Services, William Beaumont Hospital, Royal Oak, MI 48073.
Fryer
N L
NL
Decker
D A
DA
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D002955:Leucovorin / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000627:therapeutic use*; D012189:Retrospective Studies
D011899:Ranitidine; D002955:Leucovorin; D005472:Fluorouracil