Leukotriene antagonist S 872419 A for early-phase treatment of chemical burn in the rabbit eye.
S 872419 A, a specific receptor antagonist of peptide leukotrienes, was tested in the early-phase treatment of chemically burned eye (0.25 mol/l sodium hydroxide) of the rabbit. The drug was topically applied 5 times a day in a 1% solution, controls were the untreated opposite eye. Gross and microscopic investigations indicated that S 872419 A inhibits the inflammatory response of the chemically burned anterior eye segment. The parameters of healing considered (epithelial regeneration, corneal clouding and swelling, infiltration with polymorphonuclear leukocytes) suggest inhibition of lipoxygenase-mediated reactions in the tissue. PGF2 alpha levels were the same in aqueous humour of treated and untreated eyes. Further experiments with S 872419 A and other nonsteroidal drugs should improve the anti-inflammatory therapy of the chemically burned eye.
Struck
H G
HG
Department of Ophthalmology, Martin Luther University, Halle-Wittenberg, Germany.
Geiser
H
H
Block
H U
HU
Mest
H J
HJ
Tost
M
M
D000818:Animals; D001082:Aqueous Humor / Q000737:chemistry; D002057:Burns, Chemical / Q000188:drug therapy*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D015237:Dinoprost / Q000032:analysis; D004848:Epithelium / Q000187:drug effects / Q000293:injuries; D005126:Eye Burns / Q000139:chemically induced / Q000188:drug therapy*; D006880:Hydroxy Acids / Q000627:therapeutic use*; D007634:Keratitis / Q000188:drug therapy / Q000473:pathology; D020024:Leukotriene Antagonists; D015289:Leukotrienes / Q000008:administration & dosage / Q000627:therapeutic use; D009504:Neutrophils / Q000187:drug effects; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects
D006880:Hydroxy Acids; D020024:Leukotriene Antagonists; D015289:Leukotrienes; C077787:S 872419 A; D015237:Dinoprost