Decrease in number of CD16(Leu 11)+CD45RA(2H4)+ cells and defective production of natural killer cytotoxic factor in childhood acute lymphoblastic leukemia.
CD16 or CD45RA is known to be a functional molecule, which provides activation signals in natural killer (NK) cells or T cells, respectively. To dissect the decreased NK activity in childhood acute lymphoblastic leukemia (ALL), the expression of CD16 (Leu 11) or CD45RA (2H4) and the production of natural killer cytotoxic factor (NKCF) were investigated. CD16+ cells or CD45RA+ cells in peripheral blood lymphocytes were not decreased as compared with controls, however, CD16+CD45RA+ cells in ALL (4%) were lower (p less than 0.05) than controls (17%). The production of NKCF in ALL patients (9.2%) was lower (p less than 0.05) than controls (16.5). These data suggest that the decreased NK activity in ALL patients can be attributable at least in part to the functional impairment of NK cells to produce NKCF.
Yamada
S
S
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Komiyama
A
A
D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis*; D000943:Antigens, Differentiation / Q000096:biosynthesis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage; D016827:CD8 Antigens / Q000096:biosynthesis; D002648:Child; D003602:Cytotoxicity, Immunologic; D003907:Dexamethasone / Q000008:administration & dosage; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006649:Histocompatibility Antigens / Q000096:biosynthesis*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D055646:Killer Factors, Yeast; D017493:Leukocyte Common Antigens; D015122:Mercaptopurine / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D014176:Protein Biosynthesis; D011506:Proteins; D011961:Receptors, Fc / Q000096:biosynthesis*; D017452:Receptors, IgG; D014750:Vincristine / Q000008:administration & dosage
D015703:Antigens, CD; D000943:Antigens, Differentiation; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D006649:Histocompatibility Antigens; D055646:Killer Factors, Yeast; D011506:Proteins; D011961:Receptors, Fc; D017452:Receptors, IgG; D014750:Vincristine; D003907:Dexamethasone; D011239:Prednisolone; D015122:Mercaptopurine; D017493:Leukocyte Common Antigens; D001215:Asparaginase; D008727:Methotrexate