title: Peripheral neuropathy associated with hypereosinophilia.
abstract: Three patients with hypereosinophilia showed different forms of peripheral neuropathy: severe polyneuropathy of prevalently sensory type (case 1), mild sensory neuropathy (case 2), acute mononeuropathy of the median nerve with subclinical polyneuropathy (case 3). Hypereosinophilia was probably idiopathic, however the presence of atypical findings suggested transition to vasculitides or collagen disease. Sural nerve biopsy in cases 1 and 2 showed features of axonopathy in both, although of different severity, reflecting the variability of clinical involvement and, probably, heterogeneous pathogenic mechanisms. Peripheral nerve involvement associated with hypereosinophilia may be related to neurotoxicity of eosinophils, or to vascular damage.
authors.affiliation: Ospedale Civile di Montecchio, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Guidetti
authors.forename: F
authors.initials: F
authors.lastname: Gemignani
authors.forename: S
authors.initials: S
authors.lastname: Terenziani
authors.forename: P
authors.initials: P
authors.lastname: Ragni
authors.forename: G
authors.initials: G
authors.lastname: Fornaciari
authors.forename: D
authors.initials: D
authors.lastname: Dall'Asta
authors.forename: A
authors.initials: A
authors.lastname: Marbini
mesh_terms: D000368:Aged; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D006225:Hand / Q000294:innervation; D006801:Humans; D007866:Leg / Q000294:innervation; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010292:Paresthesia / Q000150:complications; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D011241:Prednisone