title: Induction of IgE-Fc receptor (Fc epsilon R2/CD23) expression on lymphocytes from patients with mite-allergic bronchial asthma by mite allergen.
abstract: The present study was designed to clarify whether Fc epsilon R2 can be induced on lymphocytes of patients with bronchial asthma by stimulation with specific antigen. Expression of Fc epsilon R2 on freshly isolated lymphocytes (at 0 hour) was significantly higher in both patients with mite-allergic asthma and those with nonmite-atopic asthma than in healthy individuals. In addition, expression of Fc epsilon R2 on lymphocytes was still higher in patients during acute asthma. Marked induction of Fc epsilon R2 on lymphocytes was observed 48 hours or more after addition of mite-allergen in patients with mite-allergic asthma while no Fc epsilon R2 expression was induced in patients with nonmite-atopic asthma or healthy individuals. Induction of Fc epsilon R2 expression was not observed at 30 minutes, two hours, and five hours, which are equivalent in kinetics to immediate asthmatic response and late asthmatic response in allergen inhalational challenges.
authors.affiliation: Fourth Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Chihara
authors.forename: N
authors.initials: N
authors.lastname: Nakano
authors.forename: D
authors.initials: D
authors.lastname: Kurachi
authors.forename: M
authors.initials: M
authors.lastname: Seguchi
authors.forename: T
authors.initials: T
authors.lastname: Mouri
authors.forename: H
authors.initials: H
authors.lastname: Uenishi
authors.forename: S
authors.initials: S
authors.lastname: Nakajima
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology* / Q000378:metabolism; D001249:Asthma / Q000097:blood / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure*; D008925:Mites / Q000276:immunology* / Q000502:physiology; D011961:Receptors, Fc / Q000276:immunology* / Q000378:metabolism; D017455:Receptors, IgE; D013997:Time Factors
chemical_list: D000485:Allergens; D000944:Antigens, Differentiation, B-Lymphocyte; D011961:Receptors, Fc; D017455:Receptors, IgE