title: The life-saving effect of physostigmine in haemorrhagic shock.
abstract: The intravenous injection of physostigmine (70 micrograms kg-1) produces a life-saving effect in acute haemorrhagic shock in non-anaesthetized rabbits. This effect is most probably due to a transfer of tissue fluids into circulation. The crucial beneficial effect of physostigmine might be a decrease of the capillary hydrostatic pressure due to changes in pre- to postcapillary resistance ratio. Both lines of defence comprise a normalization of blood pressure and normalization of blood volume, thus saving the life of the animal.
authors.affiliation: Institute for Medical Research, Military Medical Academy, Belgrade, Yugoslavia.
authors.forename: J
authors.initials: J
authors.lastname: Savić
authors.forename: V M
authors.initials: VM
authors.lastname: Varagić
authors.forename: D
authors.initials: D
authors.lastname: Prokić
authors.forename: S
authors.initials: S
authors.lastname: Vujnov
authors.forename: M
authors.initials: M
authors.lastname: Prostran
authors.forename: G
authors.initials: G
authors.lastname: Zunić
authors.forename: D
authors.initials: D
authors.lastname: Stanimirović
authors.forename: M
authors.initials: M
authors.lastname: Rastovac-Bogdanović
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D010830:Physostigmine / Q000627:therapeutic use*; D011817:Rabbits; D012769:Shock / Q000188:drug therapy*; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D010830:Physostigmine