[The European experience of liver-kidney transplantation for primary hyperoxaluria type I. Prevention of recurrent intrarenal oxalate deposits].
Following simultaneous liver-kidney transplantation for primary hyperoxaluria type I, although the missing enzyme is provided by the liver transplant, there is a risk of recurrent calcium oxalate crystal formation in the implanted kidney. The necessary kidney protection methods are extrarenal blood purification, principally haemodialysis and haemofiltration, and an abundant diuresis ensured by copious fluid intakes together with prescription of diuretics. These therapeutic measures reduce the oxalate concentrations in both blood and urine. Oxalates are excreted in large amounts over a long period, owing to the formation of important tissue deposits during systemic oxalosis.
Lloveras
J J
JJ
Service de Néphrologie, CHU de Rangueil, Toulouse.
Dupré-Goudable
C
C
Rey
J P
JP
Sporer
P
P
Durand
D
D
Ton That
H
H
Suc
J M
JM
D005500:Follow-Up Studies; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000517:prevention & control* / Q000601:surgery; D007669:Kidney Calculi / Q000517:prevention & control*; D016030:Kidney Transplantation / Q000379:methods*; D016031:Liver Transplantation / Q000379:methods*; D010070:Oxalates / Q000378:metabolism; D012008:Recurrence; D006435:Renal Dialysis / Q000379:methods*
D010070:Oxalates
Expérience européenne de transplantation hépato-rénale dans l'hyperoxalurie primitive de type I. Prévention de la récidive des dépôts d'oxalate au niveau du rein.