IgG anti-IgE autoantibodies in immunoregulation.
Human sera contain anti-IgE autoantibodies with diverse biological functions in vitro. Opposite functions can be shown for triggering of IgE-mediated histamine release from human basophils in terms of anaphylactogenic or nonanaphylactogenic autoantibodies. Furthermore, autoantibodies are either capable of removing IgE from the surface of CD23-positive cells of binding more IgE to such cells. A similar dichotomy seems also to exist for the effect of autoantibodies on human IgE mRNA synthesis as well as IL-4-induced proliferation of human mononuclear cells. Thus, anti-IgE autoantibodies may represent a key factor in the manifestation and the development of allergic disease.
Stadler
B M
BM
Institute of Clinical Immunology, University of Berne, Inselspital, Switzerland.
Gang
Q
Q
Vogel
M
M
Jarolim
E
E
Miescher
S
S
Aebischer
I
I
de Weck
A L
AL
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis / Q000502:physiology*; D000936:Antigen-Antibody Complex / Q000032:analysis; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis / Q000502:physiology*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis / Q000276:immunology*; D007074:Immunoglobulin G / Q000502:physiology*; D011961:Receptors, Fc / Q000276:immunology; D017455:Receptors, IgE
D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D000944:Antigens, Differentiation, B-Lymphocyte; D001323:Autoantibodies; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E