title: Gammavinylgaba increases high voltage spindle activity in control and nucleus basalis-lesioned rats after sub-chronic treatment.
abstract: The present study investigates the effects of gammavinylgaba (GVG, 4 days treatment at 50 and 200 mg/kg), a gabatransaminase inhibitor, on the high-voltage spindle (HVS) activity in control and nucleus basalis-lesioned rats. GVG treatment at 200 mg/kg, but not at 50 mg/kg increased HVS activity in controls. GVG greatly aggravated nucleus basalis magnocellularis (NBM) lesion-induced increase in HVS activity at 200 mg/kg, but not at 50 mg/kg. The present results demonstrate that partial NBM lesions increase the HVS inducing potency of GVG.
authors.affiliation: Department of Neurology, University of Kuopio, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Riekkinen
authors.forename: J
authors.initials: J
authors.lastname: Sirviö
authors.forename: M
authors.initials: M
authors.lastname: Riekkinen
authors.forename: A
authors.initials: A
authors.lastname: Valjakka
authors.forename: E
authors.initials: E
authors.lastname: Koivisto
authors.forename: P
authors.initials: P
authors.lastname: Riekkinen
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000614:Aminocaproates / Q000494:pharmacology*; D000818:Animals; D004569:Electroencephalography / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013377:Substantia Innominata / Q000502:physiology*; D013997:Time Factors; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D000614:Aminocaproates; D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase; D020888:Vigabatrin