Lack of pharmacokinetic and pharmacodynamic interactions between ketoconazole and prednisolone.
The effects of ketoconazole on the pharmacokinetics and pharmacodynamics of intravenous prednisolone (14.8 mg) were assessed in six healthy volunteers. Subjects were studied with and without receiving ketoconazole, 200 mg orally for 6 days. The addition of ketoconazole did not significantly change the clearance (96 +/- 11 versus 90 +/- 11 ml/hr/kg), mean residence time (4.29 +/- 0.43 versus 4.45 +/- 0.59 hours), volume of distribution (0.41 +/- 0.02 versus 0.40 +/- 0.02 L/kg), or plasma protein binding characteristics of prednisolone. The suppressive effects of prednisolone on serum cortisol, blood basophil, and helper T lymphocyte values, assessed by the ratio of the area under the curve (AUC) after prednisolone administration to the baseline AUC, was not altered significantly by ketoconazole. The 50% inhibitory concentration values derived from pharmacodynamic models developed to describe the direct suppressive effects of corticosteroids indicated no alteration in intrinsic sensitivity in the presence of ketoconazole. Ketoconazole does not appear to alter the pharmacokinetics or the pharmacodynamic response patterns of selected direct suppression effects of single low doses of prednisolone.
Yamashita
S K
SK
Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo 14260.
Ludwig
E A
EA
Middleton
E
E
Jusko
W J
WJ
D000328:Adult; D000704:Analysis of Variance; D001491:Basophils / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002940:Circadian Rhythm; D004341:Drug Evaluation; D004347:Drug Interactions; D006632:Histamine / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007654:Ketoconazole / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D007958:Leukocyte Count; D008297:Male; D011239:Prednisolone / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D011485:Protein Binding; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology
D001798:Blood Proteins; D006632:Histamine; D011239:Prednisolone; D007654:Ketoconazole; D006854:Hydrocortisone