[Coronary vascular reserve in heart transplantation. Normalization after therapy for rejection].
Acute rejection is associated with severe impairment of coronary reserve in heart transplants. To evaluate the effects of rejection therapy, coronary reserve was assessed in 6 patients before and after treatment of an acute episode of rejection. Coronary reserve was significantly enhanced after rejection therapy (4.7 +/- 0.8, vs 2.3 +/- 0.5, P less than 0.001) and was not significantly different from that of transplanted patients without rejection (5.4 +/- 0.8). This study provides evidence that alterations of coronary reserve due to acute rejection are reversible after treatment of the rejection episode.
Nitenberg
A
A
Physiologie et d'Explorations Fonctionnelles, CHU Xavier-Bichat, Paris.
Tavolaro
O
O
Benvenuti
C
C
Loisance
D
D
Foult
J M
JM
Hittinger
L
L
Castaigne
A
A
Cachera
J P
JP
Vernant
P
P
D000208:Acute Disease; D003327:Coronary Disease / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D006084:Graft Rejection / Q000187:drug effects*; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use
D007166:Immunosuppressive Agents
Réserve vasculaire coronaire dans la transplantation cardiaque. Normalisation après traitement du rejet.