title: [Treatment of uncomplicated urinary tract infections: cefuroxime vs cotrimoxazole].
abstract: Forty females (ages 15-74) with community-acquired, uncomplicated urinary tract infections were studied. Clinical and microbiological efficacy of cefuroxime (250 mg td) and trimethoprim sulfamethoxazole (160/800 mg td) used for 7 days were evaluated. The microorganisms found in the pre-treatment urinary cultures were: Escherichia Coli (85%), Klebsiella Pneumoniae (12.5%), and E. Agglomerans (2.5%). They were all susceptible to cefuroxime, and 42.5% were resistant to trimethoprim sulfamethoxazole (Kirby-Bauer). These findings show that trimethoprim sulfamethoxazole should not be used empirically while waiting for the results of urinary cultures, and that cefuroxime is a good alternative in these cases. Clinical cure was observed in all, and bacteriological cure in 75% of the pts treated with both antimicrobial agents. Relapses and reinfections were detected during follow-up emphasizing the importance of intra and post-treatment urinary cultures.
authors.affiliation: Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Chile.
authors.forename: M
authors.initials: M
authors.lastname: Castrillón
authors.forename: I
authors.initials: I
authors.lastname: Palma
authors.forename: G
authors.initials: G
authors.lastname: Azócar
authors.forename: R
authors.initials: R
authors.lastname: Tapia
authors.forename: A
authors.initials: A
authors.lastname: Silva
authors.forename: S
authors.initials: S
authors.lastname: Pescio
authors.forename: R
authors.initials: R
authors.lastname: Aguayo
authors.forename: V
authors.initials: V
authors.lastname: Triantafilo
authors.forename: J
authors.initials: J
authors.lastname: Contreras
authors.forename: L
authors.initials: L
authors.lastname: Thompson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002444:Cefuroxime / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002444:Cefuroxime
vernacular_title: Tratamiento de las infecciones del tracto urinario no complicadas: cefuroximo versus cotrimoxazol.