Pseudorabies virus-induced suppression of major histocompatibility complex class I antigen expression.
The ability of pseudorabies virus (PrV) to down-modulate expression of major histocompatibility complex class I antigens in murine and porcine cells was investigated. When quantified by flow cytometry, surface expression of class I Kk and Dk antigens on PrV-infected cells decreased by 60% or more. Down-modulation was associated with a decrease in total cellular class I antigens, indicating regulation at the transcriptional or posttranscriptional level. PrV did not suppress expression of transferrin receptor, suggesting a selective regulatory mechanism.
Mellencamp
M W
MW
Department of Microbiology, Miami University, Oxford, Ohio 45056.
O'Brien
P C
PC
Stevenson
J R
JR
D000818:Animals; D015536:Down-Regulation; D011558:Herpesvirus 1, Suid / Q000235:genetics / Q000502:physiology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D007108:Immune Tolerance; D011818:Rabies / Q000276:immunology; D011990:Receptors, Transferrin / Q000276:immunology; D014158:Transcription, Genetic
D015395:Histocompatibility Antigens Class I; D011990:Receptors, Transferrin