Host immunosuppression following orthotopic bowel allotransplantation in rats using low-dose cyclosporine.
This study shows that Le rats bearing total bowel allografts treated with CyA (5 mg/kg for 14 days) demonstrated within one month immunological unresponsiveness to donor and third-party alloantigens as determined by MLR responses. Assays performed in long-term survivors (greater than 100 days) showed a continued depressed MLR response to antigen-specific (BN) alloantigens. The response to third-party (ACI) alloantigens was not significantly depressed. After the long-term bowel recipients rejected donor skin grafts, the MLR responses were increased over control, but the transplanted bowel remained intact.
Grogan
J B
JB
Department of Surgery, University of Mississippi Medical Center, Jackson 39216.
Shimazu
R
R
Masaki
Y
Y
Raju
S
S
D000818:Animals; D003524:Cyclosporins / Q000627:therapeutic use*; D006084:Graft Rejection; D007165:Immunosuppression Therapy; D007422:Intestines / Q000637:transplantation*; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D009130:Muscle, Smooth / Q000637:transplantation; D051381:Rats; D011912:Rats, Inbred ACI; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D016038:Skin Transplantation / Q000276:immunology; D014184:Transplantation, Homologous
D003524:Cyclosporins