Differentiation in embryonal neuroepithelial tumors of the central nervous system.
Ninety-six embryonal neuroectodermal tumors were studied histologically and immunohistologically with a panel of antibodies including glial, neuronal, epithelial, mesodermal, and myelin markers. In 71 tumors there was glial and neuronal differentiation and expression both of an S (photoreceptor) antigen and vimentin. In five tumors there was only glial differentiation and in 20 tumors only neuronal differentiation. No reactivity for myelin and epithelial markers was found. Histologic and immunohistologic findings identified various degrees of differentiation in different tumors, which was bipolar (glial and neuronal) in most tumors and unipolar in the remainder. The authors suggest that their findings may be the result of normal or aberrant oncogenic differentiation, agreeing with the nomenclature of the World Health Organization classification for these tumors with and the inclusion of a category for ependymoblastoma.
Cruz-Sánchez
F F
FF
Banco de Tejidos Neurológicos, Service of Neurology, Hospital Clínico y Provincial, University of Barcelona, Spain.
Rossi
M L
ML
Hughes
J T
JT
Moss
T H
TH
D000293:Adolescent; D000328:Adult; D000943:Antigens, Differentiation / Q000032:analysis*; D001932:Brain Neoplasms / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D004806:Ependymoma / Q000473:pathology; D005260:Female; D005729:Ganglioneuroma / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000473:pathology; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000032:analysis; D009447:Neuroblastoma / Q000473:pathology; D010871:Pinealoma / Q000473:pathology; D012175:Retinoblastoma / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D013120:Spinal Cord Neoplasms / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D000943:Antigens, Differentiation; D005904:Glial Fibrillary Acidic Protein; D009419:Nerve Tissue Proteins; D009418:S100 Proteins; D014746:Vimentin