[Premature rupture of membranes at preterm. Meta-analysis of the effect of steroids on the prevention of respiratory distress syndrome].
The use of steroids in premature rupture of the membranes is controversial. We used meta-analysis of published results to evaluate the effect of steroid treatment to prevent fetal respiratory distress syndrome associated to premature rupture of the membranes and found that a 30% reduction in the rate of this complication was observed in patients receiving steroids. The 95% confidence interval for relative risk was 0.610 to 0.815. However, infectious complication of the mother increased (mean relative risk 1.68, 95% Cl 1.16-2.44) but not those of the neonate. These results support the use of steroids in order to prevent fetal respiratory distress syndrome in pregnant women with premature rupture of membranes.
Oyarzún
E
E
Departamento de Obstetricia y Ginecología, P Universidad Católica de Chile, Santiago de Chile.
Gómez
R
R
Romero
R
R
Bracken
M
M
D000704:Analysis of Variance; D001424:Bacterial Infections / Q000453:epidemiology; D016001:Confidence Intervals; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000517:prevention & control*; D012307:Risk Factors; D013256:Steroids / Q000627:therapeutic use*
D013256:Steroids
Rotura prematura de membranas de pretérmino. Meta-análisis del efecto de esteroides en la prevención del síndrome de distress respiratorio.