Inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin papilloma by saponins.
Papillomas in mouse skin were initiated with 390 nmol of 7,12-dimethylbenz(a)anthracene and 1 week later, were promoted 2 times a week with 4.1 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA). Five saponin-related compounds used as potential anti-inflammatory agents were applied in the same position with 82 nmol. Saponin-related compounds effectively inhibited tumor formation in the sensitive mouse stock even when these compounds were given 1 h prior to TPA treatment. These results suggested that there was a general correlation between the anti-inflammatory and antitumor-promoting activities of saponins.
Tokuda
H
H
Department of Microbiology, Faculty of Medicine, Kyoto University, Japan.
Konoshima
T
T
Kozuka
M
M
Kimura
T
T
D000818:Animals; D005260:Female; D004854:Herpesvirus 4, Human / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D012503:Saponins / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*; D014775:Virus Activation / Q000187:drug effects
D012503:Saponins; D013755:Tetradecanoylphorbol Acetate