[Diffusion of piperacillin into the sinuses of patients with nosocomial sinusitis].
Six mechanically ventilated patients with nosocomial sinusitis received an intravenous infusion of 4 g of piperacillin. Piperacillin concentrations were measured in the serum and in drained sinusal fluid 1, 2, 3, 4, 6 and 8 hours after the beginning of the infusion. A peak piperacillin level of 33 mg/l was obtained 30 minutes after the end of administration, and concentrations of 14 mg/l or more persisted for up to 8 hours. It is concluded that piperacillin can be used to treat patients with nosocomial sinusitis.
Holzapfel
L
L
Service de Réanimation, Centre Hospitalier, Bourg-en-Bresse.
Jehl
F
F
Miranda
P
P
Lyonnet
F
F
Coupry
A
A
Demingeon
G
G
Carrère-Debat
D
D
D000328:Adult; D000368:Aged; D001692:Biological Transport; D003428:Cross Infection / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D015523:Maxillary Sinusitis / Q000188:drug therapy*; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000187:drug effects*; D010878:Piperacillin / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D012121:Respiration, Artificial
D010878:Piperacillin
Diffusion de la pipéracilline dans les sinus chez les malades atteints de sinusite nosocomiale.