title: Fibrinolytic parameters and lipoprotein (a) levels in plasma of patients with coronary artery disease.
abstract: Fibrinolysis and lipid disturbances have been considered as independent risk factors for coronary artery disease. Besides this, lipoprotein(a), which is characterized by its homology with plasminogen may interfere with the fibrinolytic function. To evaluate the eventual correlation between fibrinolytic parameters, lipoprotein (a) and other risk factors, 46 patients with coronary artery disease (34 with chronic angina pectoris and 12 with myocardial infarction) were studied. Increased basal values of t-PA antigen (8.2 and 6.6 vs. 4.2 ng/ml) but decreased response after stimulus (2.2 and 1.8 vs. 3.8 ng/ml) and increased levels of lipoprotein(a) (24.7 and 35.9 vs. 10.5 mg/dl) were the most relevant differences between coronary artery disease patients and controls. No correlation between lipoprotein(a) and fibrinolytic parameters was found. Therefore plasma concentration of the main plasma fibrinolytic parameters and lipoprotein(a) seem to be unrelated though the relevance of this interaction at a local level needs to be studied.
authors.affiliation: Department of Haematology, Hospital Ramón y Cajal, Alcalá University, Madrid, Spain.
authors.forename: L J
authors.initials: LJ
authors.lastname: García Frade
authors.forename: J J
authors.initials: JJ
authors.lastname: Alvarez
authors.forename: I
authors.initials: I
authors.lastname: Rayo
authors.forename: M C
authors.initials: MC
authors.lastname: Torrado
authors.forename: M A
authors.initials: MA
authors.lastname: Lasunción
authors.forename: A
authors.initials: A
authors.lastname: García Avello
authors.forename: A
authors.initials: A
authors.lastname: Hernandez
authors.forename: E
authors.initials: E
authors.lastname: Marín
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000097:blood*; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a); D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D015849:Plasminogen Inactivators / Q000097:blood; D012307:Risk Factors; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D008055:Lipids; D017270:Lipoprotein(a); D008074:Lipoproteins; D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator