[Reaction of neurons of the cerebral cingular area in rats to damage of the central monoaminergic systems].
Intracisternal injection of specific neurotoxins 6-oxydopamine and 5,7-dioxytryptamine, producing certain disorders in catecholaminergic and serotoninergic systems respectively, is accompanied with some ultrastructural rearrangements in the proper neurons of the rat cerebral cingular cortex. In the experimental material an essential increase in the amount of intranuclear inclusions--vacuole- and myelin-like--of fibrillar origin is observed. More often than in the control connection of the endoplasmic reticulum with the nuclear membrane is noted. Hypertrophy of cisterns in the Golgi complex, abundance of coated vesicles in its region, dilatation of cisterns of the endoplasmic reticulum are observed. The character of the ultrastructural rearrangements demonstrates certain changes in activity of metabolic processes of these cells, the changes being more pronounced in the case, when the cerebral serotoninergic system is damaged. The reaction of the cerebral cingular zone to injection of neurotoxins is characterized with a selective manifestation and is restricted with certain nervous cells of the II-V layers. According to their ultrastructural organization, these neurons can be considered as stellate and pyramidal.
Otellin
V A
VA
Fedosikhina
L A
LA
D015116:5,7-Dihydroxytryptamine / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology; D002799:Cholinergic Fibers / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D003593:Cytoplasm / Q000187:drug effects* / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D008297:Male; D008854:Microscopy, Electron; D008959:Models, Neurological; D009474:Neurons / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D016627:Oxidopamine / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D015116:5,7-Dihydroxytryptamine; D016627:Oxidopamine
Reaktsiia neĭronov poiasnoĭ kory bol'shogo mozga krysy na povrezhdenie tsentral'nykh monoaminergicheskikh sistem.