Plasma kinetics of atropine and ipratropium in rats after different routes of administration evaluated by a radioreceptor assay.
Plasma kinetics of atropine and ipratropium was assessed in rat after i.v. (10 mg/kg), oral and i.p. (50 mg/kg) administration by a radioreceptor assay (RRA). The volume of the central compartment and the clearance of both drugs were very similar (about 3 L/kg and 3.5 L/h/kg respectively) while the steady state volume of distribution and the terminal half-life of atropine were higher than those of ipratropium. After i.p. administration the kinetics of ipratropium was very different from what was expected after the i.v. experiment.
Urso
R
R
Instituro di Farmacologia, Universita di Siena, Italia.
Segre
G
G
Bianchi
E
E
Bruni
G
G
Dal Pra
P
P
Fiaschi
A I
AI
D000284:Administration, Oral; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D001921:Brain / Q000378:metabolism; D006168:Guinea Pigs; D006207:Half-Life; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D009241:Ipratropium / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D011813:Quinuclidinyl Benzilate / Q000493:pharmacokinetics; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains
D011813:Quinuclidinyl Benzilate; D001285:Atropine; D009241:Ipratropium