Inhibitory effect of inhaled procaterol on anaphylactic bronchoconstriction and thromboxane A2 production in guinea-pigs.
This study was designed to examine whether an inhaled beta 2-agonist, procaterol, inhibits thromboxane A2 (TXA2) production induced by antigen challenge in passively sensitized guinea-pigs in vivo. Antigen-induced bronchoconstriction was markedly inhibited by pre-treatment with procaterol. Inhaled procaterol significantly reduced in a dose-dependent manner the increment in TXB2 concentration in bronchoalveolar lavage fluid obtained 5 min after antigen challenge. Aerosol administration of procaterol significantly inhibited bronchoconstriction induced by inhaled histamine. These results suggest that inhalation of procaterol has an inhibitory effect on antigen-induced TXA2 production as well as a protective effect against bronchoconstriction induced by bronchoactive agents.
Fujimura
M
M
Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan.
Sakamoto
S
S
Nishi
K
K
Saito
M
M
Miyake
Y
Y
Matsuda
T
T
D000280:Administration, Inhalation; D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001980:Bronchi / Q000187:drug effects*; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000494:pharmacology; D004983:Ethanolamines / Q000008:administration & dosage / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008297:Male; D008689:Methacrylates / Q000494:pharmacology; D017265:Procaterol; D011453:Prostaglandins / Q000096:biosynthesis; D013928:Thromboxane A2 / Q000096:biosynthesis*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors
D000941:Antigens; D001993:Bronchodilator Agents; D004983:Ethanolamines; D008689:Methacrylates; D011453:Prostaglandins; D013928:Thromboxane A2; D006632:Histamine; D013930:Thromboxane-A Synthase; C034364:ozagrel; D017265:Procaterol