title: Synthesis and its properties of oligonucleotide analogue containing thiocarbamate interlinkages.
abstract: Novel nucleotide analogues have been synthesized from morpholine subunits with thiocarbamate linkages. They indicated much stronger interaction with poly U or poly dT than the corresponding natural oligodeoxyribonucleotides. Solubility of the analogues in water was greatly enhanced by introducing sulfate groups at their both ends.
authors.affiliation: Research Laboratories, Nippon Shinyaku Co. Ltd, Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohgi
authors.forename: K
authors.initials: K
authors.lastname: Ishiyama
authors.forename: H
authors.initials: H
authors.lastname: Tomi
authors.forename: J
authors.initials: J
authors.lastname: Yano
mesh_terms: D015394:Molecular Structure; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature; D013859:Thiocarbamates / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D013859:Thiocarbamates