[The effect of a one-time, continous administration of a stressor (alcohol) on the secretory activity of the glomerular and fascicular zone of the adrenal cortex].
In the aim of establishing what kind of mechanisms of steroidogenesis stimulation are put into motion in healthy males by a one-term, continual stressor influence, research was carried out concerning the influence of alcohol on the concentration of 11-OHCS and DHA in the plasma of healthy males after alcoholic stress (0.3 g/kg of body weight), by physical strain then by alcohol, with infusions of ACTH and infusions of niamide then alcohol. After a one-term alcohol stress and after physical strain followed by alcohol stress two maximums are observed during the change of 11-OHCS and DHA concentrations: in the 15th and 120th minute of stress application, while in the 60th and 240th minute the values range in the limits of basal concentrations. During the course of niamide infusions, the concentrations of 11-OHCS decrease and their increase does not occur even after subsequent stress by alcohol. In each stress test, the changes of 11-OHCS concentrations are gradual and continual. It is considered that the H-H-C system reaction to the continual stress influence develops in two phases, and first there comes to an activation of the serotoninergic system of the CNS. It is assumed that the serotoninergic system of the CNS essentially influences the function of the H-H-C system, but not the basal activity as well.
Fehér
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Zdravstveni centar dr Gere Istvan Senta.
D015062:11-Hydroxycorticosteroids / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D003687:Dehydroepiandrosterone / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D015383:Zona Fasciculata / Q000378:metabolism*; D015384:Zona Glomerulosa / Q000378:metabolism*
D015062:11-Hydroxycorticosteroids; D000431:Ethanol; D003687:Dehydroepiandrosterone
Jednokratni, kontinuirani uticaj stresora (alkohola) na sekretornu aktivnost zone glomerulosa i fascikulata kore nadbubrezne zlezde.