Effects of nicotinic agonists on the NMDA receptor.
The cholinergic nicotinic agonists (-)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced responses in rat cortical neurons in culture. In addition we found that (-)nicotine, (+)nicotine, and lobeline, but not the nicotine metabolite (-)cotinine nor acetylcholine, were able to displace [3H]dizocilpine ([3H]MK 801) binding in well-washed membranes obtained from rat brain. These results show that certain nicotinic agonists can interact with the NMDA receptor and block its function.
Aizenman
E
E
Department of Physiology, University of Pittsburgh School of Medicine, PA 15261.
Tang
L H
LH
Reynolds
I J
IJ
D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000378:metabolism; D005731:Ganglionic Stimulants / Q000494:pharmacology*; D005998:Glycine / Q000494:pharmacology; D008120:Lobeline / Q000494:pharmacology; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism; D009538:Nicotine / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D013237:Stereoisomerism
D005731:Ganglionic Stimulants; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D009538:Nicotine; D008120:Lobeline; D005998:Glycine