Synergistic and antagonistic effects on fatty acid composition in the liver mitochondria of rats by thyroidectomy and streptozotocin-administration.
The content of individual fatty acid component in mitochondria of livers from thyroidectomized (Tx) and streptozotocin (STZ)-induced diabetic rats was measured to investigate how different hormones are interrelated to control the amount of a particular fatty acid in mitochondria. The results showed (1) diabetes, in general, affected fatty acid contents more severely than hypothyroidism, regardless of the direction of the changes; (2) Hypothyroidism and diabetes affected antagonistically the contents of C16 species and C18:1, which belong to a de novo synthesis (oleate series). However, the two pathological conditions affected synergistically those of higher unsaturated species, eg. C18:2, C20:3 and C20:4, which belong to a dietary-dependent synthesis (linoleate series). These results strongly indicated that each desaturation site and elongation site is affected in a preferential order by either thyroid hormone or insulin, and that hypothyroidism and diabetes have their effects differently on the process of de novo synthesis and the pathways initiated from an essential fatty acid in mitochondria.
Nishida
M
M
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Sasaki
T
T
Terada
H
H
Kawada
J
J
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis*; D007037:Hypothyroidism / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin; D013965:Thyroidectomy
D005227:Fatty Acids; D013311:Streptozocin