[Conflicting xenograft. Role of preoperative total lymphoid irradiation].
This study deals with an experimental model of discordant cardiac xenograft between 24 donor lambs of the Préalpes race and 24 recipient Camborough pigs divided up into 4 groups: I control (6) without immunosuppressive treatment; II (5) with pharmacological immunosuppression (IP); III (13) with PI and total lymphoid irradiation (TLI) and immediate graft, divided up into IIIa (5) with high-rate (HR) TLI and IIIb with low-rate (LR) TLI; IV (4) with a two-week lapse between TLI and grafting. The best graft survival rate (GSR) is obtained either after delayed LR-TLI or after LR-TLI without delay. This study seems to be the first one demonstrating that for discordant xenogenic grafts, TLI associated to PI with cyclosporin A (Cy A) significantly prolongs the survival of the graft (30 times).
Tixier
D
D
Centre de Recherches chirurgicales, C.N.R.S. URA 1431 (Pr Loisance), Université Paris XIII, Créteil.
Levy
C
C
Le Bourgeois
J P
JP
Leandri
J
J
Loisance
D
D
D000818:Animals; D000961:Antilymphocyte Serum / Q000032:analysis; D016572:Cyclosporine / Q000008:administration & dosage; D006084:Graft Rejection / Q000276:immunology* / Q000473:pathology; D006085:Graft Survival; D016027:Heart Transplantation; D015182:Lymphatic Irradiation / Q000379:methods*; D011300:Preoperative Care / Q000379:methods; D012756:Sheep; D013552:Swine; D014183:Transplantation, Heterologous
D000961:Antilymphocyte Serum; D016572:Cyclosporine
Xénogreffes discordantes. Le rôle de l'irradiation lymphoïde totale pré-opératoire.