[Prevention of peritoneal adhesion formation with a combination of carboxymethyl-cellulose and papain: experimental study].
The inhibitory action of sodium carboxymethylcellulose (CMC) and papain (PP) in peritoneal adhesions formation, were studied in Wistar rats. After ether anesthesia and a midline laparotomy incision, the right parietal peritoneum was pinched with a fine hemostat and the pinched peritoneal fold was then ligated. This maneuver was repeated thrice creating four point as if they were little "polyps" with a standardized size. Before closing the incision, it was deposited on the four points of each animal the following substances: group A--saline solution; group B--CMC 2%; group C--PP 0.4% in distilled water; group D--CMC 2% + PP 0.2%; group E--CMC 2% + PP 0.4%. After ten days, the rats were sacrificed and classified according to the number of "points" that showed adhesions with the abdominal structures. There was a statistically significant decrease in the incidence of adhesions only in the group E (CMC + PP 0.4%).
Parra
O M
OM
Instituto de Ciéncias Biomédicas (ICB), Universidade de São Paulo.
Saad
W A
WA
Ferri
S
S
Peduto
L
L
Ferraz Neto
J B
JB
Dal Colletto
G M
GM
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D010206:Papain / Q000627:therapeutic use*; D010537:Peritoneum; D051381:Rats; D011919:Rats, Inbred Strains; D000267:Tissue Adhesions / Q000517:prevention & control
D004338:Drug Combinations; D010206:Papain; D002266:Carboxymethylcellulose Sodium
Prevenção da formação de aderências peritoneais pela associação carboximetilcelulose-papaína: estudo experimental.