Isolation of Bacillus stearothermophilus constituent that suppresses mouse mixed leukocyte reaction in vitro.
A novel immunosuppressant, Fr.5-B, has been isolated from the debris of Bacillus stearothermophilus UK563 autolysate. Fr.5-B suppressed mouse mixed leukocyte reaction at doses ranging from 10(-4) to 1 microgram/ml, but not proliferation stimulated by concanavalin A and lipopolysaccharide.
Kohama
Y
Y
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Murayama
N
N
Tanaka
K
K
Inada
A
A
Nakanishi
T
T
Itoh
M
M
Ying
X
X
Mimura
T
T
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D001411:Geobacillus stearothermophilus / Q000737:chemistry*; D007166:Immunosuppressive Agents / Q000302:isolation & purification*; D008070:Lipopolysaccharides / Q000302:isolation & purification; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D003208:Concanavalin A