title: Echocardiographic assessment of doxazosin on left ventricular mass in patients with essential hypertension.
abstract: A single daily dose of doxazosin taken during a 12-week period produced a significant reduction in blood pressure and left ventricular mass index in patients with mild or moderate hypertension. The systolic shortening coefficient was also increased and a trend in the improvement of ejection fraction, rate of circumferential fiber shortening, systolic contraction time, and preejective/ejective ratio was observed. No change in heart rate was recorded and no patients had side effects. The serum lipid profile was modified favorably, particularly with regard to the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio. By producing a reduction in blood pressure and left ventricular mass while favorably modifying the serum lipid profile, doxazosin produced a beneficial change in the overall coronary heart disease risk profile.
authors.affiliation: Hypertension Unit, Hospital Universitario, Caracas, Venezuela.
authors.forename: P
authors.initials: P
authors.lastname: Monsalve
authors.forename: O
authors.initials: O
authors.lastname: Vera
authors.forename: F
authors.initials: F
authors.lastname: Pérez Acuña
authors.forename: O
authors.initials: O
authors.lastname: Medina
authors.forename: K
authors.initials: K
authors.lastname: Ostojich
authors.forename: B
authors.initials: B
authors.lastname: López
authors.forename: N
authors.initials: N
authors.lastname: Torres
authors.forename: V
authors.initials: V
authors.lastname: Lugo de Franco
authors.forename: R
authors.initials: R
authors.lastname: Fonseca
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000000981:diagnostic imaging* / Q000188:drug therapy; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000453:epidemiology; D017292:Doxazosin; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012307:Risk Factors; D014687:Venezuela / Q000453:epidemiology
chemical_list: D000959:Antihypertensive Agents; D008055:Lipids; D002784:Cholesterol; D017292:Doxazosin; D011224:Prazosin