title: Complement receptor type 1 (CR1, CD35) expression on peripheral T lymphocytes: both CD4- and CD8-positive cells express CR1.
abstract: T lymphocytes from 42 healthy blood donors were examined for expression of CR1 on the cell surface using a fluorescence-activated cell sorter. The fraction of CR1-positive T lymphocytes varied in the range from 1 to 8% (median 2.4%). The CR1-positive T lymphocytes constituted a homogeneous group of cells regarding both size and granulation; they seemed to be larger and more granulated than the average T lymphocytes. The CR1-expressing T lymphocytes were found both in the CD4- and in the CD8-positive subpopulations of T lymphocytes, and although the CD4-positive cells expressed CR1 with a slightly higher percentage than did the CD8-positive cells, this difference was not significant. The number of CR1-positive T lymphocytes did not correlate with the level of CR1 on erythrocytes. The presence of CR1 on a small T lymphocyte population suggests that CR1 on T lymphocytes might play a role in the immune regulation.
authors.affiliation: Department of Autoimmune Serology, Statens Seruminstitut, Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Rødgaard
authors.forename: L D
authors.initials: LD
authors.lastname: Christensen
authors.forename: B S
authors.initials: BS
authors.lastname: Thomsen
authors.forename: A
authors.initials: A
authors.lastname: Wiik
authors.forename: G
authors.initials: G
authors.lastname: Bendixen
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D017252:CD3 Complex; D015704:CD4 Antigens / Q000096:biosynthesis*; D016827:CD8 Antigens / Q000096:biosynthesis*; D004912:Erythrocytes / Q000276:immunology; D005434:Flow Cytometry; D015870:Gene Expression; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D011951:Receptors, Complement / Q000096:biosynthesis*; D017463:Receptors, Complement 3b; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D011948:Receptors, Antigen, T-Cell; D011951:Receptors, Complement; D017463:Receptors, Complement 3b