Familial influence on type 1 (insulin-dependent) diabetes mellitus by relatives with either insulin-treated or type 2 (non-insulin-dependent) diabetes mellitus.
In 161 patients with Type 1 (insulin-dependent) diabetes mellitus, the familial influences by first-degree relatives with insulin-treated diabetes mellitus (ITDM), and by first-degree relatives with Type 2 (non-insulin-dependent) diabetes mellitus were investigated. A control group consisted of 730 subjects with normal glucose tolerance. Independent odds ratios (adjusted for covariates) for Type 1 diabetes in offspring were 7.0 (p < 0.001) with first-degree ITDM relatives, and 2.5 (p < 0.01) with first-degree Type 2 diabetic relatives. When relatives were separated into parents and siblings, odds ratios for Type 1 diabetes in offspring were higher due to paternal ITDM and paternal Type 2 diabetes, than in cases of maternal diabetes. Siblings with ITDM, but not siblings with Type 2 diabetes, also showed increased odds ratios. Thus, both familial ITDM and familial Type 2 diabetes showed influences in separate ways on the presence of Type 1 diabetes in offspring, indicating separate genetic mechanisms.
Cederholm
J
J
Department of Internal Medicine, University Hospital, University of Uppsala, Sweden.
Wibell
L
L
D000704:Analysis of Variance; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D009679:Nuclear Family; D016017:Odds Ratio; D012016:Reference Values