[Roles of oxytocin, serotonin and norepinephrine in regulation of prolactin release during stress].
The stimulating effects of oxytocin (OT), norepinephrine (NE) and serotonin on prolactin (PRL) release in vitro and in vivo have been well documented. In this paper, experiments were made to further demonstrate their roles in regulation of restraint stress-induced PRL release. Male Sprague-Dawley rats were used and carefully handled according to all requirements for stress experiments. Cerebral injection of anti-OT antiserum and 6-OHDA significantly attenuated the increase of PRL during stress, whereas 5,6-dihydroxytryptamine appeared to have no effect on stress-induced increase of PRL. Plasma PRL in animals injected with methysergide showed that the stress increased even more markedly as compared with control animals. However, there was no difference between methysergide-injected animals with and without stress. The results indicate that OT as well as NE may play an important role in stress-induced PRL release, while the serotoninergic (5-HT) system may not.
Chen
L
L
Institute of Basic Medical Sciences, Beijing.
D000818:Animals; D007276:Injections, Intraventricular; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine / Q000494:pharmacology; D010121:Oxytocin / Q000502:physiology*; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D012701:Serotonin / Q000502:physiology*; D013315:Stress, Psychological
D012701:Serotonin; D010121:Oxytocin; D016627:Oxidopamine; D011388:Prolactin; D009638:Norepinephrine; D008784:Methysergide