[Features of the chlorine-dependent effect of acetylcholine and neutral amino acids on neurons of the Achatina snail].
Responses of neurons in cerebral ganglia of an African giant snail (Achatina fulica) to acetylcholine (ACh), gamma-aminobutyric acid (GABA) and glycine (Gly) were investigated. Cl-dependent currents induced by these mediators in neurons of one and a half month old snail sibs were inhibited by dibutyryl-cAMP and strychnine. Inhibition of ACh-responses by 10(-8) mol/l GABA was mimicked by applications of dibutyryl-cAMP and isobutylmethylxanthine. GABA- and Gly-responses exhibited complete cross-desensitization, but this effect was absent for ACh and GABA (or Gly). On the basis of pharmacological dependences of GABA- and Gly-responses it is suggested that these amino acids act on the same receptor-channel complex in neurons of young snails. ACh-, GABA- and Gly-induced chloride currents were independent in neurons of four years old snails.
Diatlov
V A
VA
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002712:Chlorides / Q000502:physiology*; D005998:Glycine / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D012908:Snails / Q000502:physiology*; D013331:Strychnine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D002712:Chlorides; D005680:gamma-Aminobutyric Acid; D003994:Bucladesine; D013331:Strychnine; D000109:Acetylcholine; D005998:Glycine
Osobennosti khlorzavisimogo vliianiia atsetilkholina i neĭtralnykh aminokislot na neĭrony ulitki-akhatiny.