[Effect of microsurgical resection of the ovary on fertility in patients with polycystic ovary resistant to clomiphene citrate].
Thirteen patients with clomiphene citrate resistant polycystic ovary syndrome (PCO-CR) were documented by clinical and endocrine profile. Exogenous gonadotropins (HMG, hFSH, hCG), or gonadotrophin releasing hormone agonist (GnRHa) plus gonadotropins represent a new approach to induce ovulation in these (PCO-CR) patients. 92% of these patients ovulated with exogenous gonadotropin, nevertheless the pregnancy rate was only 53%. Five out seven PCO-RC patients did not achieve pregnancy with exogenous gonadotrophins, but they did after ovarian wedge resection. It is interesting to note that four of these patients achieved their second and third pregnancy without any therapy. The authors conclude that the ovarian wedge resection may had to improve in the quality of ovulation in this very selective group of infertile patients.
Devoto
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Departamento de Obstetricia y Ginecología, Hospital Clínico San Borja-Arriarán, Facultad de Medicina, Universidad de Chile, Santiago.
Sir
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Izquierdo
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CA
Alba
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Fuentes
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A
D000328:Adult; D002996:Clomiphene / Q000494:pharmacology; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000601:surgery; D008866:Microsurgery; D010053:Ovary / Q000601:surgery; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome
D002996:Clomiphene
Efecto de la resección microquirúrgica del ovario en la fertilidad de pacientes con ovario poliquístico resistente al citrato de clomifeno.