Gonadal hormones affect the hypothermia induced by serotonin1A (5-HT1A) receptor activation.
Subcutaneous injection of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in mice caused hypothermia which was antagonized by pindolol. The hypothermic effect of 8-OH-DPAT was pronounced in female than in male mice. The sex difference in the hypothermic effect was also observed after pretreatment with proadifen. The hypothermic effect of 8-OH-DPAT was attenuated by ovariectomy. In the ovariectomized mice, the effect of 8-OH-DPAT on rectal temperature was enhanced by chronic estradiol and the enhancement was blocked by simultaneous administration of testosterone. In male mice the hypothermic effect of 8-OH-DPAT was enhanced by castration. These results suggest that gonadal hormones affect the 5-HT1A receptor-mediated response.
Matsuda
T
T
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Nakano
Y
Y
Kanda
T
T
Iwata
H
H
Baba
A
A
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002369:Castration; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007035:Hypothermia / Q000139:chemically induced* / Q000503:physiopathology; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D010052:Ovariectomy; D011335:Proadifen / Q000008:administration & dosage / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D012727:Sex Characteristics; D013739:Testosterone / Q000494:pharmacology*; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage / Q000494:pharmacology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013764:Tetrahydronaphthalenes; D013739:Testosterone; D004958:Estradiol; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D011335:Proadifen