An evaluation of the possible protective effects of neonatal striatal transplants against kainic acid-induced lesions.
The present study examined the recent report that transplantation of neonatal striatal tissue into kainic acid (KA) lesioned striatum protected the contralateral striatum from a subsequent KA lesion. We did not find a significant difference in the survival rate of animals that received neonatal striatal transplants into a KA lesioned striatum followed by a subsequent lesion of the contralateral striatum compared to those animals that received bilateral KA-induced striatal lesions alone. The tissue transplants did not protect against the degeneration of striatal neurons induced by KA. Indeed, the survival rate was very low (25%) in the transplant groups. A second experiment was also performed to examine whether a neonatal striatal transplant might reduce the severe syndrome of aphagia and adipsia associated with KA lesions of the striatum. Animals that received the neonatal striatal transplants showed increased aphagia and adipsia compared to animals only receiving the KA lesion. Again, the transplant group had a very low survival rate (10%). The present study was unable to confirm that neonatal striatal transplants protect against KA lesions either by themselves or in conjunction with a recent KA lesion.
Nash
D R
DR
Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267-0559.
Kaplan
S M
SM
Norman
A B
AB
Sanberg
P R
PR
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001835:Body Weight; D001927:Brain Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D016380:Brain Tissue Transplantation / Q000502:physiology*; D003342:Corpus Striatum / Q000637:transplantation*; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology; D014184:Transplantation, Homologous
D011805:Quinolinic Acids; D017378:Quinolinic Acid; D007608:Kainic Acid