Stimulating effect of thyroid hormone on insulin-like growth factor I release and synthesis by perfused rat liver.
The direct effect of thyroid hormone on insulin-like growth factor I (IGF-I) release and synthesis was investigated in perfused rat liver. Physiological doses (from 50 to 1000 ng/dl) of 3,5,3'-triiodothyronine administration in the perfusing medium increased IGF-I release and concentration in the perfused liver in a dose dependent manner. While physiological doses (from 2 to 10 micrograms/dl) of thyroxine did not affect the release and synthesis of IGF-I in the perfused liver. These results suggest that 3,5,3'-triiodothyronine, but not thyroxine, directly enhances the release and synthesis of IGF-I in a dose dependent manner in the rat liver.
Ikeda
T
T
First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Fujiyama
K
K
Hoshino
T
T
Tanaka
Y
Y
Takeuchi
T
T
Mashiba
H
H
Tominaga
M
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000494:pharmacology; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D007334:Insulin-Like Growth Factor I; D013974:Thyroxine