title: [Determination of intact parathyroid hormone in patients with calcium metabolism disorders].
abstract: We have used an immunoradiometric assay (IRMA) to measure intact PTH. The serum-levels of PTH followed a log-normal distribution in a population of 85 healthy post-menopausal women, with a geometric mean of 1.9 pmol/l and a range of 0.8-6.1 pmol/l. The correlation between measurements performed using the IRMA and a radioimmunoassay which measured the C-terminal portion of the PTH molecule was 0.85. It was only the IRMA, however, that could measure subnormal values. Two of 27 patients with primary hyperparathyroidism had PTH-values in the upper reference interval. The rest of the patients had elevated levels. Patients with hypercalcemia due to malignancy had subnormal or low normal (less than 2.5 pmol/l) PTH values. Half of the patients with hypoparathyroidism had PTH below the limit of detection. Four subjects with familial hypercalciuric hypercalcemia had normal (3) or slightly elevated PTH-levels.
authors.affiliation: Hormonlaboratoriet Aker sykehus, Oslo.
authors.forename: K I
authors.initials: KI
authors.lastname: Birkeland
authors.forename: J A
authors.initials: JA
authors.lastname: Falch
authors.forename: K M
authors.initials: KM
authors.lastname: Gautvik
authors.forename: F T
authors.initials: FT
authors.lastname: Gjestvang
authors.forename: N
authors.initials: N
authors.lastname: Holst
authors.forename: E
authors.initials: E
authors.lastname: Haug
mesh_terms: D000328:Adult; D002118:Calcium / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000097:blood* / Q000209:etiology; D007011:Hypoparathyroidism / Q000097:blood; D015592:Immunoradiometric Assay / Q000379:methods; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012016:Reference Values
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium
vernacular_title: Måling av intakt parathormon hos pasienter med kalsiumforstyrrelser.