Complications of hepatic arterial infusion chemotherapy.
Chemotherapy by direct hepatic arterial infusion (HAI) results in reduction in tumor mass in a large percentage of patients. The authors reviewed records for 45 patients with metastatic cancer of the gastrointestinal tract who underwent HAI chemotherapy with floxuridine, administrated via an implanted pump. Twenty-seven of the 45 patients suffered complications, including gastrointestinal ulceration (18%), hepatitis (24%), sclerosing cholangitis (7%), and abscess (2%). The complication rates in this series were similar to those previously reported. The toxicity of HAI chemotherapy continues to limit its efficacy.
Pozniak
M A
MA
Department of Radiology, University of Wisconsin Hospital and Clinics, Madison 53792.
Babel
S G
SG
Trump
D L
DL
D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000000981:diagnostic imaging / Q000209:etiology; D015209:Cholangitis, Sclerosing / Q000139:chemically induced / Q000000981:diagnostic imaging; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology; D005770:Gastrointestinal Neoplasms / Q000473:pathology; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial / Q000009:adverse effects*; D008100:Liver Abscess / Q000000981:diagnostic imaging / Q000209:etiology; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
D005467:Floxuridine