Late phase allergic reaction to a CT contrast medium (iotrolan).
A 46-year-old male developed wide-spread erythema and edema after intravenous injection of a CT contrast medium (iotrolan). The skin eruption appeared at 6 h, reached a maximum at 9 to 12 h, and faded within 36 h after injection. A challenge with an intradermal injection of the agent provoked the same reaction where the eruption had originally appeared, but had no effect on previously unaffected regions. Histopathologic examination revealed a perivascular infiltration of small round cells, and a few neutrophils, and eosinophils in the dermis and focal spongiosis in the epidermis. This is the first report of a late phase allergic skin reaction induced by iotrolan.
Kanzaki
T
T
Department of Dermatology, Nagoya City University Medical School, Japan.
Sakagami
H
H
D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000009:adverse effects*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C033300:iotrolan