DRw8 microvariation: a new DRB1 allele identified in association with DQw7 in American blacks.
In the American black population, DRw8 is commonly found in association with DQw7 and an undefined HLA-D specificity. Polymerase chain reaction amplification was used to obtain DRB1 cDNA clones from two unrelated individuals expressing this haplotype. The DRB1 sequence is most similar to a sequence found in cells expressing DRw8, DQw4, Dw8.2 differing at the protein level by a single amino acid substitution at position 86.
Hurley
C K
CK
Department of Microbiology, Georgetown University Medical School, Washington, DC 20007.
Lee
K W
KW
Mickelson
E
E
Masewicz
S
S
Johnson
A H
AH
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D044383:Black People / Q000235:genetics*; D004247:DNA / Q000032:analysis; D014644:Genetic Variation / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D014481:United States; D001741:Black or African American
D006683:HLA-DQ Antigens; C069546:HLA-DQ7 antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C041559:HLA-DR8 antigen; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II; D015345:Oligonucleotide Probes; D004247:DNA