Expression of gamma delta T lymphocytes derived from human intestinal biopsies.
Although most T cells express the alpha/beta TCR, the gamma/delta TCR is expressed only on a small percentage of peripheral lymphocytes and CD3+ intestinal T cells. The most striking feature is a wide variation in the proportion of gamma/delta+ T cells in freshly isolated peripheral blood cells from normal individuals and patients with IBD. The augmentation of the gamma/delta+ T cell subpopulation derived from human intestinal biopsies after repeated stimulation with MT, even in the absence of filler cells, suggests that gamma/delta+ cells from human gut mucosa may play a role in generating a primary immune response to MT.
Volk
B A
BA
Medizinische Universitätsklinik Freiburg, Innere Medizin II, Universität Freiburg, BRD.
Niessner
M
M
Amann
B
B
Fauser
A A
AA
Gerok
W
W
D002469:Cell Separation; D002478:Cells, Cultured; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000473:pathology; D007413:Intestinal Mucosa / Q000166:cytology* / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology; D010835:Phytohemagglutinins / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*
D010835:Phytohemagglutinins; D016692:Receptors, Antigen, T-Cell, gamma-delta