Histomorphometric analysis of weight bearing bones of diabetic and non-diabetic sand rats (Psammomys obesus).
Femoral and tibial bones of diabetic sand rats were compared to those of non-diabetic sand rats (Psammomys obesus) of the same age range. Three morphometric parameters were examined: trabecular bone volume, length of epiphyseal cartilage (proliferative and mature) and cortical thickness of mid-shaft of tibia. There were no statistically significant differences between the test and control animals for the last two parameters. By contrast the trabecular bone volume of the diabetic animals was less than half that of the control animals indicating a substantial loss of trabecular bone mass. This study suggests that Psammomys obesus is a suitable model for studying the effects of diabetes mellitus on bone mass, provided that weight bearing bones are used.
Amir
G
G
Department of Pathology, Hadassah University Hospital, Mount Scopus, Jerusalem.
Adler
J H
JH
Menczel
J
J
D000818:Animals; D001696:Biomechanical Phenomena; D001835:Body Weight; D015519:Bone Density; D001842:Bone and Bones / Q000502:physiology* / Q000503:physiopathology; D002356:Cartilage / Q000502:physiology / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005260:Female; D005269:Femur / Q000502:physiology / Q000503:physiopathology; D005849:Gerbillinae; D008297:Male; D013977:Tibia / Q000502:physiology / Q000503:physiopathology