Plasma xanthine oxidase and resistance to hypoxia: effect of purines and alcohol administration.
The administration of allopurinol significantly increased resistance to repeated hypobaric hypoxia, while hypoxanthine decreased it. The administration of adenine or inosine (25 mg/kg) was without effect. The results show pathogenic significance of xanthine oxidase-dependent production of free oxygen radicals in posthypoxic damage. In other experiments, the administration of 50% ethanol (12 ml/kg) by gastric catheter increased plasma xanthine oxidase activity in both rats and hamsters.
Novák
L
L
First Institute of Medical Chemistry, Faculty of Medicine I, Charles University, Prague, Czechoslovakia.
Stípek
S
S
Zima
T
T
Trojan
S
S
D000225:Adenine / Q000494:pharmacology; D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D006224:Cricetinae; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D007042:Hypoxanthines / Q000494:pharmacology; D000860:Hypoxia / Q000097:blood*; D007288:Inosine / Q000494:pharmacology; D051379:Mice; D010100:Oxygen / Q000494:pharmacology; D011687:Purines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014969:Xanthine Oxidase / Q000097:blood*
D007042:Hypoxanthines; D011687:Purines; D000431:Ethanol; D007288:Inosine; D000493:Allopurinol; D014969:Xanthine Oxidase; D000225:Adenine; D010100:Oxygen