title: Prevention and treatment of atrophic rhinitis in pigs with Getroxel, chlorquinaldol and oxytetracycline.
abstract: The sensitivity of ten Bordetella bronchiseptica and ten Pasteurella multocida strains, each isolated from cases of atrophic rhinitis (AR), was examined in tube dilution test. Getroxel, chlorquinaldol and oxytetracycline and the former two ones combined with trimethoprim inhibited the growth of both species in vitro. The minimum inhibitory and the minimum bactericidal concentration was less than 0.5 microgram/ml. When efficacy was tested in SPF in the group fed a combination of Getroxel, chlorquinaldol and oxytetracycline (60 mg, 240 mg and 360 mg/kg of feed, respectively), P. multocida disappeared from the nasal cavity by the end of a 30-day treatment. B. bronchiseptica was reisolated in low numbers from 2 out of 9 piglets. The daily body mass gain was by 7.9% higher and the feed conversion rate was by 19% better than in the control group. After slaughter, only mild signs of AR were seen in 3 out of 9 piglets treated with the above-mentioned drug combination, while in the control group severe lesions were observed in 8 out of 9 pigs. In treated commercial herds P. multocida disappeared from the nasal cavity of the piglets by the end of the treatment (42nd day of life), but the B. bronchiseptica strains could not be completely eliminated. Due to the treatment, mortality between 2 and 6 weeks of age decreased by 0.8-7.6%. Daily body mass gain was, on the average, 16.4% higher, the amount of feed needed for 1 kg body mass gain was by 15.3% lower and the duration of fattening was by 30.8 days shorter than in the control groups.
authors.affiliation: Department of Microbiology and Infectious Diseases, University of Veterinary Science, Budapest, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Varga
authors.forename: K
authors.initials: K
authors.lastname: Magyar
authors.forename: L
authors.initials: L
authors.lastname: Fodor
authors.forename: A
authors.initials: A
authors.lastname: Romváry
mesh_terms: D000818:Animals; D016950:Bordetella bronchiseptica / Q000187:drug effects; D002218:Carbadox / Q000627:therapeutic use*; D002750:Chlorquinaldol / Q000627:therapeutic use*; D010118:Oxytetracycline / Q000627:therapeutic use*; D016979:Pasteurella multocida / Q000187:drug effects; D012222:Rhinitis, Atrophic / Q000188:drug therapy / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*
chemical_list: D002750:Chlorquinaldol; D002218:Carbadox; D010118:Oxytetracycline