Atrial natriuretic peptide-like immunoreactive cells in the guinea pig inner ear.
Using specific antibodies against cardiodilatin/atrial natriuretic peptide (CDD/ANP) in a conventional immuno-histochemical method (PAP) we located ANP/CDD-like immuno-reactive cells related to the secretory area, to the sensory and to the neuronal area in the compartments of the inner ear (cochlea, utricle/ampulla, and endolymphatic sac). Immunoreactive cells were unevenly distributed in the different compartments as well as within the cochlear space. Our findings suggest that ANP/CDD may play a role in the local control of fluid and electrolyte homeostasis of the inner ear. ANP/CDD-binding sites and ANP/CDD-like immunoreactivity in the inner ear may also indicate that the peptide has an additional paracrine and/or autocrine function in the organ.
Meyer zum Gottesberge
A M
AM
Forschungslabor der HNO Klinik der Universität Düsseldorf, F.R.G.
Gagelmann
M
M
Forssmann
W G
WG
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D003051:Cochlea / Q000166:cytology / Q000378:metabolism; D007758:Ear, Inner / Q000166:cytology / Q000378:metabolism*; D004712:Endolymphatic Sac / Q000166:cytology / Q000378:metabolism; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism; D012444:Saccule and Utricle / Q000166:cytology / Q000378:metabolism
D009124:Muscle Proteins; D009320:Atrial Natriuretic Factor; C040651:cardiodilatin