title: Circadian rhythms of body temperature and drinking and responses to thermal challenge in rats after PCPA.
abstract: Body temperature (Tb) and drinking were measured for five days in male and female rats. On day 6 (S1) the rats were injected with saline. On day 7 (P1) they were injected with PCPA (300 mg/kg IP). Measurements continued for 12 days. Immediately after PCPA Tb dropped. After that, the amplitude of the daily Tb rhythm was significantly decreased from days P2-P5. Females were more affected than males. Nocturnality of drinking was decreased on days P2-P4. Because the peak of the Tb rhythm advanced after PCPA, while the peak of the drinking rhythm was delayed, we conclude that the attenuation of the Tb rhythm was a direct result of PCPA treatment rather than a masking effect due to the attenuation of other rhythms. Other rats were thermally challenged during the first week post-PCPA. There were no differences in ability to regulate Tb in the cold, and the small variations in the heat were overshadowed by gender differences.
authors.affiliation: Department of Psychology, University of Illinois, Urbana-Champaign 61820.
authors.forename: E
authors.initials: E
authors.lastname: Satinoff
authors.forename: S
authors.initials: S
authors.lastname: Kent
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: D
authors.initials: D
authors.lastname: Megirian
authors.forename: J M
authors.initials: JM
authors.lastname: Tomkowiak
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002940:Circadian Rhythm; D003080:Cold Temperature; D004327:Drinking Behavior / Q000187:drug effects*; D005260:Female; D010134:Fenclonine / Q000494:pharmacology*; D006358:Hot Temperature; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology; D012737:Sex Factors; D013696:Temperature
chemical_list: D012701:Serotonin; D010134:Fenclonine