title: Mechanisms of musculoskeletal sepsis.
abstract: Musculoskeletal infection is extraordinarily resistant to treatment. Bacterial colonization is discussed as well as host defense systems and antibiotic resistance.
authors.affiliation: Musculoskeletal Sciences Research Institute, Herndon, Virginia.
authors.forename: A G
authors.initials: AG
authors.lastname: Gristina
authors.forename: P T
authors.initials: PT
authors.lastname: Naylor
authors.forename: Q N
authors.initials: QN
authors.lastname: Myrvik
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001422:Bacterial Adhesion; D001672:Biocompatible Materials / Q000009:adverse effects*; D015169:Colony Count, Microbial; D004352:Drug Resistance, Microbial; D004866:Equipment Contamination; D005549:Foreign-Body Reaction / Q000209:etiology / Q000276:immunology; D006801:Humans; D007121:Immunocompetence; D009135:Muscular Diseases / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D010019:Osteomyelitis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D018805:Sepsis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials