title: [The mechanism of the formation of a circadian rhythm of bone marrow proliferation in rats].
abstract: Flow cytofluorimetry and statmokinetic method were used to study the circadian rhythm of bone marrow proliferation in Pliss' lymphosarcoma-bearing and intact rats. These data were compared to those obtained in the study of the mitotic activity of the bone marrow in cancer patients. It was found that, already at early stage, tumor affected the circadian rhythm of bone marrow proliferation, reducing the amplitude of oscillations. A model simulating formation of the circadian rhythm of the bone marrow was suggested basing on the possibility to arrest cells at the end of G1 phase. The rate of transition of G1 cells to S phase was determined not only by endogenous "set-points" of the rhythm which formed the basic wave of proliferation but also by conditions of animal upkeep.
authors.forename: M A
authors.initials: MA
authors.lastname: Blank
authors.forename: V A
authors.initials: VA
authors.lastname: Gushchin
authors.forename: S V
authors.initials: SV
authors.lastname: Tokalov
authors.forename: L I
authors.initials: LI
authors.lastname: Korytova
authors.forename: L S
authors.initials: LS
authors.lastname: Lubotskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Klestova
authors.forename: A S
authors.initials: AS
authors.lastname: Iagunov
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D001854:Bone Marrow Cells; D002455:Cell Division; D002940:Circadian Rhythm; D004247:DNA / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000737:chemistry / Q000503:physiopathology; D008297:Male; D008938:Mitosis; D009368:Neoplasm Transplantation; D051381:Rats; D013997:Time Factors
chemical_list: D004273:DNA, Neoplasm; D004247:DNA
vernacular_title: O mekhanizme formirovaniia sutochnogo ritma proliferatsii kostnogo mozga u krys.