No crossover reactions to citalopram or paroxetine among patients hypersensitive to zimeldine.
Five patients who reacted with the hypersensitive syndrome to zimeldine showed no reaction to one of two other selective 5-HT reuptake inhibitors, citalopram or paroxetine. This further strengthens the impression that the mechanism for the hypersensitivity syndrome induced by zimeldine does not seem to be related primarily to the 5-HT reuptake inhibition as such.
Bengtsson
B O
BO
Department of Psychiatry, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
Lundmark
J
J
Wålinder
J
J
D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents; D015283:Citalopram / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D017374:Paroxetine; D010880:Piperidines / Q000009:adverse effects* / Q000627:therapeutic use; D012702:Serotonin Antagonists; D015031:Zimeldine / Q000009:adverse effects* / Q000627:therapeutic use
D000928:Antidepressive Agents; D010880:Piperidines; D012702:Serotonin Antagonists; D015283:Citalopram; D015031:Zimeldine; D017374:Paroxetine