Over-expression of superoxide dismutase and lack of surface-thiols in spermatozoa: inherent defects in oligospermia.
The infertility associated with oligospermia had been suspected to be a direct consequence of the impairment in fertilizing ability of the spermatozoa rather than the presence of low sperm number per se. This study defines some of these impairments, which include an over expression of superoxide dismutase, poor superoxide anion radical generation capacity and a lack of sperm-surface thiols in oligospermia. The abnormal biochemical make-up of spermatozoa could explain their low fertilizing ability in case of oligospermia.
Sinha
S
S
School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, Madhya Pradesh, India.
Pradeep
K G
KG
Laloraya
M
M
Warikoo
D
D
D002462:Cell Membrane / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D007700:Kinetics; D008297:Male; D009845:Oligospermia / Q000201:enzymology / Q000378:metabolism*; D012016:Reference Values; D013094:Spermatozoa / Q000201:enzymology / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000032:analysis; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism
D013438:Sulfhydryl Compounds; D013481:Superoxides; D013482:Superoxide Dismutase