title: Activation of the matrix metalloproteinase inhibitor complex by a low molecular weight angiogenic factor.
abstract: Tissue inhibitor of matrix metalloproteinases is the major inhibitor of the collagenolytic enzymes and the inhibitory complex has been thought to be irreversible. In this paper we show that a low molecular weight non-protein endothelial cell stimulating angiogenic factor is able to reactivate the enzyme from the inhibitor complex and liberate free inhibitor. The importance of an angiogenic factor able to initiate limited degradation of extra-cellular matrix such that space is created for new capillary growth is discussed.
authors.affiliation: Rheumatology Research Unit E6 Addenbrookes Hospital, Cambridge, U.K.
authors.forename: B
authors.initials: B
authors.lastname: McLaughlin
authors.forename: T
authors.initials: T
authors.lastname: Cawston
authors.forename: J B
authors.initials: JB
authors.lastname: Weiss
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D001685:Biological Factors / Q000494:pharmacology*; D002845:Chromatography; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008970:Molecular Weight; D012867:Skin / Q000201:enzymology; D019714:Tissue Inhibitor of Metalloproteinases; D014357:Trypsin / Q000494:pharmacology
chemical_list: D043925:Angiogenesis Inducing Agents; D001685:Biological Factors; D006023:Glycoproteins; D007457:Iodine Radioisotopes; D019714:Tissue Inhibitor of Metalloproteinases; D014357:Trypsin; D003012:Microbial Collagenase