RRR-alpha-tocopheryl succinate enhances T cell mitogen-induced proliferation and reduces suppressor activity in spleen cells derived from AEV-infected chickens.
RRR-alpha-tocopheryl succinate was demonstrated to be a potent in vitro modulator of retrovirus-induced immune abnormalities. Spleen cells from avian erythroblastosis virus (AEV)-infected chickens exhibit suppressed T cell mitogen-induced proliferative responses and elevated levels of suppressor T cell activity. In vitro addition of RRR-alpha-tocopheryl succinate resulted in amelioration of these abnormalities. Antioxidants including Trolox (a water-soluble analogue of RRR-alpha-tocopherol with antioxidant properties) and a combination of butylated hydroxyanisole and butylated hydroxytoluene were able to restore immune functions to levels similar to those achieved with RRR-alpha-tocopheryl succinate treatment. Aspirin, an irreversible inhibitor of cyclooxygenase activity, was capable of ameliorating some of the AEV-induced immune dysfunctions. These studies suggest a role for the antioxidant functions of RRR-alpha-tocopheryl succinate in modulation of retrovirus-induced immune abnormalities.
Kline
K
K
Division of Nutrition, University of Texas, Austin 78712-1097.
Sanders
B G
BG
D001355:Alpharetrovirus / Q000276:immunology*; D000818:Animals; D001353:Avian Leukosis / Q000276:immunology; D001717:Birds; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002645:Chickens; D008934:Mitogens / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013491:Suppressor Factors, Immunologic / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*; D014810:Vitamin E / Q000494:pharmacology*
D008934:Mitogens; D013491:Suppressor Factors, Immunologic; D014810:Vitamin E