Platelet function in the peri-operative period.
Although platelets have an important role in haemostasis and in thrombosis, what happens to platelet function postoperatively is not well understood. We investigated platelet function in the peri-operative period by measuring total platelet count and several products released by activated platelets, thromboxane, betathromboglobulin and lyso-platelet activating factor (lyso-PAF). The only changes detected were a significant rise in total platelet count between 48 h and 5 days post-operation, and a progressive fall in lyso-PAF up to 48 h post-operation. It is possible that other changes may have occurred, but were an immediate effect and were not apparent at time of the first blood sample 2-3 h post-operation.
Cooper
T M
TM
University Department of Surgery, Queen Elizabeth II Medical Centre, Perth, Western Australia.
Ingram
D M
DM
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000031:analogs & derivatives / Q000378:metabolism; D010976:Platelet Count; D013514:Surgical Procedures, Operative; D013929:Thromboxane B2 / Q000378:metabolism; D001620:beta-Thromboglobulin / Q000378:metabolism
C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor; D001620:beta-Thromboglobulin; D013929:Thromboxane B2