Ethopharmacological studies on the effects of antihormones on rodent agonistic behavior with especial emphasis on progesterone.
The effects of a range of antiandrogens and antiestrogens on conflict behaviors in laboratory rats and mice are reassessed in the light of recent studies applying ethophamacological analyses (recording the full spectrum of behaviors) to such investigations. It is argued that any antihostility properties of the antiandrogen cyproterone acetate are largely a consequence of indirect actions on odor communication, whereas antiestrogens (e.g., tamoxifen and CI 680) seem to have more fundamental motivational effects in addition to communicatory actions. A detailed example of the approach is provided in which progesterone (which can be antiandrogenic) is given to rats paired in different ways. The type of pairing has a very substantial effect on the actions seen after treatment, and the ethopharmacological approach generates a better picture of antihormone effect than traditional psychopharmacological tests.
Brain
P F
PF
Biological Sciences, University College of Swansea, Wales, UK.
Simón
V M
VM
Martińez
M
M
D000378:Agonistic Behavior / Q000187:drug effects*; D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003534:Cyproterone / Q000031:analogs & derivatives / Q000494:pharmacology; D017373:Cyproterone Acetate; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D007398:Interpersonal Relations; D008027:Light; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011374:Progesterone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D013343:Styrenes / Q000494:pharmacology; D013629:Tamoxifen / Q000494:pharmacology
D000726:Androgen Antagonists; D004965:Estrogen Antagonists; D013343:Styrenes; D013629:Tamoxifen; C009266:3-(p-(alpha-(p-methoxyphenyl)beta-nitrostyryl)phenoxy)-N,N-dimethylpropylamine monocitrate; D011374:Progesterone; D017373:Cyproterone Acetate; D003534:Cyproterone