Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats.
To investigate the effect of pulmonary alveolar hypoxia on the synthesis and release of endothelin (ET)-1, ET-1-like immunoreactivity (-LI) levels of the lung and plasma were measured in conscious unrestrained rats under hypoxic conditions. Sixty-min exposure to alveolar hypoxia (10% O2 or 5% O2) increased the ET-1-LI level in the lung. The plasma ET-1-LI level in hypoxic rats also increased significantly. The increase of plasma and lung ET-1-LI levels were parallel to the severity of hypoxia. These results demonstrates that acute pulmonary alveolar hypoxia increases lung and plasma ET-1-LI levels in conscious unrestrained rats, suggesting a possible physiological or pathophysiological significance of ET in alveolar hypoxia.
Shirakami
G
G
Department of Medicine, Kyoto University School of Medicine, Japan.
Nakao
K
K
Saito
Y
Y
Magaribuchi
T
T
Jougasaki
M
M
Mukoyama
M
M
Arai
H
H
Hosoda
K
K
Suga
S
S
Ogawa
Y
Y
D000818:Animals; D000911:Antibodies, Monoclonal; D001127:Arginine Vasopressin / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D001784:Blood Gas Analysis; D016232:Endothelins / Q000097:blood / Q000378:metabolism*; D000860:Hypoxia / Q000097:blood / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D011650:Pulmonary Alveoli / Q000378:metabolism* / Q000502:physiology; D011863:Radioimmunoassay / Q000379:methods; D051381:Rats; D011919:Rats, Inbred Strains
D000911:Antibodies, Monoclonal; D016232:Endothelins; D001127:Arginine Vasopressin; D009320:Atrial Natriuretic Factor