title: Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity.
abstract: The suppressive activity of normal human chromosome 5 was detected by means of the chromosomal transfer technique using DT cells as recipients. A hybrid clone, which exhibited reduced tumorigenicity, contained chromosomal regions such as 5pter-p15, q21 and q33-qter. Since a familial adenomatous polyposis gene has been reported to be located at 5q21-q22, the suppressive activity of chromosome 5 might be due to this gene.
authors.affiliation: Department of Hygiene and Oncology, Tokyo Medical and Dental University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshino
authors.forename: I
authors.initials: I
authors.lastname: Horikawa
authors.forename: M
authors.initials: M
authors.lastname: Oshimura
authors.forename: Y
authors.initials: Y
authors.lastname: Yuasa
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000818:Animals; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure*; D016153:Genes, Suppressor; D006801:Humans; D006822:Hybrid Cells / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D014407:Tumor Cells, Cultured