title: Unusual serpentine hyperpigmentation associated with 5-fluorouracil. Case report and review of cutaneous manifestations associated with systemic 5-fluorouracil.
abstract: A variety of cutaneous reactions have been reported with the use of systemic 5-fluorouracil. Our patient had serpentine hyperpigmented streaks appearing 5 days after bolus infusion of 5-fluorouracil. The patient also had other skin eruptions, that is, inflammation of actinic keratoses and folliculitis limited to the forehead; these reactions have been reported previously with 5-fluorouracil medication. We report this case and review the literature on skin manifestations associated with 5-fluorouracil therapy.
authors.affiliation: Hematology/Oncology Service, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200.
authors.forename: S J
authors.initials: SJ
authors.lastname: Vukelja
authors.forename: M W
authors.initials: MW
authors.lastname: Bonner
authors.forename: M
authors.initials: M
authors.lastname: McCollough
authors.forename: P W
authors.initials: PW
authors.lastname: Cobb
authors.forename: D A
authors.initials: DA
authors.lastname: Gaule
authors.forename: P J
authors.initials: PJ
authors.lastname: Fanucchi
authors.forename: J H
authors.initials: JH
authors.lastname: Keeling
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000368:Aged; D003875:Drug Eruptions / Q000209:etiology*; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced; D010859:Pigmentation Disorders / Q000139:chemically induced*; D012004:Rectal Neoplasms / Q000188:drug therapy
chemical_list: D005472:Fluorouracil