[The cellular localization of the unusual estrogen-binding protein in the liver of rats under different hormonal states].
The localization of an unusual estrogen-binding protein (UEBP) was studied in the rat liver using indirect immunoperoxidase reaction in intact rats and after different hormonal influences. The distribution of the UEBR in normal males displays a form of a gradient with the maximum near the central veins. The gradient is absent in normal females. Castration or hypophysectomy of males, or their injection with estradiol or triiodyronine leads to a decrease in the UEBP concentration, though the gradient character of its distribution is persisting. There is a stable increase in the UEBP concentration in the first two layers of cells adjacent to the central veins in the female rat liver after ovariectomy and especially in combination with androgen injections. The revealed changes in the intensity of immunoperoxidase reaction after different hormonal influences correlate with the UEBP concentration in liver studies performed by the radioligand assay.
Shchelkunova
T A
TA
Faktor
V M
VM
Smirnov
A N
AN
Rozen
V B
VB
D000818:Animals; D002352:Carrier Proteins / Q000187:drug effects / Q000378:metabolism*; D002369:Castration; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007016:Hypophysectomy; D007124:Immunoenzyme Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology*
D002352:Carrier Proteins; D011960:Receptors, Estrogen; C010140:estrophilin; D014284:Triiodothyronine; D013739:Testosterone; D004958:Estradiol
Kletochnaia lokalizatsiia osobogo éstrogensviazyvaiushchego belka v pecheni krys pri razlichnykh gormonal'nykh sostoianiiakh.