[The effect of lowered pressure on the diastolic ventricular function after antihypertensive treatment].
Thirty hypertensive patients with increased left ventricular (LV) mass and impaired diastolic function received routinely 2 or 3 kinds of captopril, nifedipine and atenolol for a mean period of 98 days. The LV mass index (LVMI) decreased by an average of 21 g/M2, but no significant correlation between blood pressure reduction and decrease in LVMI was found. So there may be some direct effect of these antihypertensive agents on the myocardium in addition to the benefit from blood pressure reduction. Marked reduction in PVA, Ai, A/E and Ai/T-VTi (P less than 0.01) along with elevation in ratio of E/A, Ei/Ai and Ei/T-VTi (P less than 0.01) were also observed by Doppler transmitral filling studies. These results indicated that the impaired LV diastolic function in patients with hypertension can be much improved following reduction of blood pressure and LV mass.
Cai
B
B
Ruijin Hospital, Shanghai Second Medical University.
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use; D006332:Cardiomegaly / Q000209:etiology; D003971:Diastole; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000502:physiology*
D000959:Antihypertensive Agents; D001262:Atenolol; D002216:Captopril; D009543:Nifedipine