title: Isolated ACTH deficiency with absent response to corticotrophin-releasing factor--41. Evidence for a primary pituitary defect.
abstract: An 8-year-old girl presenting in hypoglycaemic coma was shown to have isolated deficiency of adrenocorticotrophic hormone (ACTH) secretion. Failure to secrete ACTH in response to intravenous administration of synthetic ovine corticotrophin-releasing factor (CRF-41) suggests that this disorder was due to a primary pituitary defect, rather than of hypothalamic origin.
authors.affiliation: Department of Child Health, St. Bartholomew's Hospital, London, UK.
authors.forename: S H
authors.initials: SH
authors.lastname: Murch
authors.forename: E P
authors.initials: EP
authors.lastname: Carter
authors.forename: S
authors.initials: S
authors.lastname: Tsagarakis
authors.forename: A
authors.initials: A
authors.lastname: Grossman
authors.forename: M O
authors.initials: MO
authors.lastname: Savage
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D002648:Child; D003346:Corticotropin-Releasing Hormone; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis* / Q000209:etiology; D010900:Pituitary Diseases / Q000150:complications / Q000175:diagnosis*; D010901:Pituitary Function Tests
chemical_list: D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone