title: [AM3 (a biological response modifier) in the treatment of recurrent aphthous stomatitis. Clinical evaluation and preliminary studies on NK (CD16) cells and their pathogenic role in the syndrome].
abstract: In an open-controlled trial--oral washes (20 patients) versus test (19 patients)--, we have studied the effects of AM3 (a new oral BRM) on clinical evolution of the recurrent stomatitis (RAS) syndrome. The results obtained at 6th month showed significant decreases on ulcer numbers (p less than 0.001) as well as in their mean duration time (p less than 0.001) due to the AM3 treatment. From a pathophysiologic point of view, the study of the NK peripheral blood cells (Leu 11/CD16) suggests the existence of two kinds of RAS-patients: those showing normal NK cell numbers (approximately 33%) and those ones showing a partial lack in the NK numbers (approximately 67%). These results suggest different rational new approaches to treatment, based on new pathophysiological concepts.
authors.affiliation: Departamento de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Virgen Macarena, Sevilla, España.
authors.forename: F
authors.initials: F
authors.lastname: Camacho
authors.forename: F L
authors.initials: FL
authors.lastname: Elorza
authors.forename: M
authors.initials: M
authors.lastname: Ortega
authors.forename: M A
authors.initials: MA
authors.lastname: Elorza
authors.forename: G
authors.initials: G
authors.lastname: Sada
authors.forename: V G
authors.initials: VG
authors.lastname: Villarrubia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD; D000943:Antigens, Differentiation; D002130:Calcium Phosphates / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006020:Glycopeptides / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011961:Receptors, Fc; D017452:Receptors, IgG; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000276:immunology* / Q000628:therapy*
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D002130:Calcium Phosphates; D006020:Glycopeptides; D007155:Immunologic Factors; D011961:Receptors, Fc; D017452:Receptors, IgG; C038773:Immunoferon
vernacular_title: AM3 (modificador de la respuesta biológica) en el tratamiento de la estomatitis aftosa recidivante. Valoración clínica y estudios preliminares sobre células NK (CD16) y su relación con la patogenia del síndrome.