[Use of flow cytometry in the study of a non-specific immunodeficiency in children. A case].
Using flow cytometry, we explored a case of nonspecific immunodeficiency in a seven month old girl with repeated infections. This method showed evidence of granulocyte phagocytosis and oxidative metabolism abnormalities suggesting the diagnosis of a variant form of chronic granulomatous disease (CGD). Findings also showed that flow cytometry can be useful to study phagocytic cells during the neonatal period as it allows rapid multiparametric analysis with a very small amount of blood.
Rabesandratana
H
H
Laboratoire d'Immunologie, CHU Lapeyronie, Montpellier.
Jouanneau
F
F
Conge
A M
AM
Lassonnery
M
M
Caravano
R
R
Rieu
D
D
Serre
A
A
D003180:Complement C3b Inactivator Proteins / Q000032:analysis; D005260:Female; D005434:Flow Cytometry / Q000379:methods*; D006098:Granulocytes / Q000276:immunology / Q000378:metabolism; D006105:Granulomatous Disease, Chronic / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007223:Infant; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D010587:Phagocytosis / Q000276:immunology / Q000502:physiology; D011961:Receptors, Fc / Q000032:analysis; D012016:Reference Values
D003180:Complement C3b Inactivator Proteins; D011961:Receptors, Fc
Utilisation de la cytométrie en flux dans l'étude des déficits de l'immunité non spécifique de l'enfant. Une observation.