[Evaluation of rearrangement of immunoglobulin genes and T cell receptors in determining low numbers of leukemic in children with acute lymphoblastic leukemia].
The samples from blood and/or bone marrow were analysed in 7 children at the time of initial diagnosis or relapse and in 9 children with clinical and hematologic remission of ALL. Molecular genetic methods were more sensitive than morphologic ones in leukemic cells detection: 5 children in remission of ALL demonstrated gene rearrangements. Clinical significance of the presence of low numbers of leukemic cells in remissions is still unknown.
Podraza
W
W
Kliniki Pediatrycznej PAM w Szczecinie.
Osipowicz
E
E
Ptaszyński
K
K
Lubiński
J
J
Fydryk
J
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics*; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*
D011948:Receptors, Antigen, T-Cell
Ocena przemieszczeń genów immunoglobulinowych i receptorów limfocytów T w wykrywaniu śladowej liczby komórek nowotworowych u dzieci z ostra białaczka limfoblastyczna.