Neural cell adhesion molecule expression, neuroendocrine differentiation and prognosis in lung carcinoma.
We investigated the expression of the neural cell adhesion molecule (NCAM) in a series of surgically resected lung carcinomas of various histological subtypes by means of a panel of monoclonal antibodies recognising different N-CAM epitopes. In a subgroup of 56 tumours, the results of immunostaining with MAb 123C3--the antibody studied most extensively in our material--were compared to the ultrastructure, and in 231 radically resected non-small cell carcinomas, with histological tumour type and with clinical follow-up data. N-CAM expression was not limited to neuroendocrine tumours, as assessed ultrastructurally. Non-small cell lung carcinomas positive for MAb 123C3 showed post-operative overall and disease-free survival times significantly shorter than 123C3-negative non-small cell carcinomas.
Kibbelaar
R E
RE
Department of Pathology, The Netherlands Cancer Institute, Amsterdam.
Moolenaar
K E
KE
Michalides
R J
RJ
Van Bodegom
P C
PC
Vanderschueren
R G
RG
Wagenaar
S S
SS
Dingemans
K P
KP
Bitter-Suermann
D
D
Dalesio
O
O
Van Zandwijk
N
N
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry; D018288:Carcinoma, Small Cell / Q000737:chemistry; D015816:Cell Adhesion Molecules, Neuronal / Q000032:analysis*; D002454:Cell Differentiation; D002460:Cell Line; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000648:ultrastructure; D011233:Precipitin Tests; D011379:Prognosis
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D015816:Cell Adhesion Molecules, Neuronal