title: Central rather than generalized obesity is related to hyperglycaemia in Asian Indian subjects.
abstract: The relationship of body mass index and waist-hip ratio with plasma glucose concentrations during an oral glucose tolerance test (OGTT) was studied in native Indian (Asian) subjects. A total of 389 subjects (131 non-diabetic, 74 impaired glucose tolerant (IGT) and 184 Type 2 diabetic (newly diagnosed and untreated] were studied. Prevalence of obesity (BMI greater than or equal to 27.0 kg m-2 in men and greater than or equal to 25.0 kg m-2 in women, 21% and 47%, respectively) was lower in people with Type 2 diabetes than that reported in white Caucasian and migrant Asian populations. Body mass index was highest in IGT subjects (26.1 (19.7-34.3) kg m-2, median (5-95th centile] and was higher in diabetic subjects (24.2 (19.3-32.2) kg m-2) than in non-diabetic control subjects (23.5 (17.1-30.0) kg m-2). However, waist-hip ratio was higher in both IGT (0.88 (0.75-0.98)) and diabetic subjects (0.88 (0.75-1.00)) than in non-diabetic control subjects (0.83 (0.70-0.97)), with no difference between the hyperglycaemic groups. On multivariate analysis, fasting as well as 2-h plasma glucose concentrations during OGTT were found to be related to waist-hip ratio (p less than 0.01) and subscapular fat thickness (p less than 0.01) but not to body mass index (or triceps fat thickness). Thus, in native Indians central obesity seems to be a more important association of hyperglycaemia than generalized obesity.
authors.affiliation: Wellcome Diabetes Study, King Edward Memorial Hospital, Pune, India.
authors.forename: K M
authors.initials: KM
authors.lastname: Shelgikar
authors.forename: T D
authors.initials: TD
authors.lastname: Hockaday
authors.forename: C S
authors.initials: CS
authors.lastname: Yajnik
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001208:Asia / Q000453:epidemiology; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000453:epidemiology; D005260:Female; D005951:Glucose Tolerance Test; D006615:Hip / Q000033:anatomy & histology; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D007194:India / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence
chemical_list: D001786:Blood Glucose