Virus-specific cytotoxic lymphocyte response in a neurotropic murine leukemia virus infection.
NFS/N mice infected with neurotropic Cas-Br-M murine leukemia virus (MuLV) at 21 days of age were resistant to neurologic disease and demonstrated MuLV-specific cytotoxic T lymphocyte (CTL) activity in spleen cells after in vitro stimulation. NFS/N mice infected with Cas-Br-M MuLV at 2 days of age failed to generate a significant MuLV-specific CTL response and developed neurologic disease 5-8 weeks later. Protection from neurologic disease transferred with fewer in vitro stimulated immune spleen cells than immune T cells from NFS/N mice infected with Cas-Br-M MuLV at 21 days of age. Cas-Br-M MuLV-specific CTL may play an important role in resistance to the paralytic effects of Cas-Br-M MuLV infection by affecting virus dissemination to the central nervous system.
Robbins
D S
DS
Retrovirus Research Center, Department of Veterans Affairs Medical Center, Baltimore, MD 21218.
Hoffman
P M
PM
D000818:Animals; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens / Q000276:immunology; D009052:Leukemia Virus, Murine / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009422:Nervous System Diseases / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D006183:H-2 Antigens