title: [Soft-tissue sarcomas of the limbs at high risk of malignity. Current role of surgery and conservative treatment].
abstract: The authors discuss the role of surgical treatment in patients with highly malignant soft tissue sarcomas in the limbs. A careful analysis is made of different therapies on the basis of the results obtained by the authors and those reported in the literature. The anatomic classification of lesions is based on functional anatomic compartments, defined as intra- or extracompartmental. If a lesion was within an intrafascial compartment, all the muscles with intact fascial sheaths have up till now been removed "en bloc" to obtain radical margins. Many authors now think that all manifest disease be removed with a generous soft tissue margin on all sides to ensure adequate local treatment. Amputation has commonly been performed for extracompartmental lesions, but a multinodal treatment programme, including limb-sparing resection and tumour-bed radiation, should now be considered if possible in the management of these tumours.
authors.affiliation: Istituto di Anatomia Chirurgica e Corso di Operazioni, Università di Genova.
authors.forename: R M
authors.initials: RM
authors.lastname: Lo Casto
authors.forename: M
authors.initials: M
authors.lastname: Taviani
authors.forename: G L
authors.initials: GL
authors.lastname: Pescio
authors.forename: N
authors.initials: N
authors.lastname: Morelli
authors.forename: A
authors.initials: A
authors.lastname: Verna
authors.forename: V
authors.initials: V
authors.lastname: Rovere
authors.forename: G
authors.initials: G
authors.lastname: Brigli
authors.forename: E
authors.initials: E
authors.lastname: Cariati
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D006801:Humans; D007866:Leg; D008297:Male; D012307:Risk Factors; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D013584:Sarcoma, Synovial / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*
vernacular_title: Sarcomi ad alto rischio di malignità dei tessuti molli degli arti. Ruolo attuale della chirurgia e trattamento conservativo.