[ADP-induced thrombocyte aggregation in hypertension patients with different degrees of left ventricular hypertrophy].
Adenosine diphosphate (ADP)-induced platelet aggregation was studied in 59 patients suffering from essential hypertension, stages I and II (WHO, 1979) with different degree of left ventricular hypertrophy (LVH) by a new optical method. Using a laser aggregation analyzer the mean aggregate radius was measured in relative units. The left ventricular myocardial mass was estimated by echocardiography. Using laser aggregatograms the significant differences in aggregation responses were revealed with 0.5 microM ADP. In a group of patients without LVH, the aggregation response to 0.5 microM ADP did not differ from that in a group of healthy volunteers. With the growth of LVH from moderate to severe the response increased in succession. The same differences which were not, however, significant were observed with higher ADP concentrations. It was also found that the new method of laser aggregometry is more sensitive than the classic Born method.
Baliakina
E V
EV
Atakhanov
Sh E
ShE
Gabbasov
Z A
ZA
Popov
E G
EG
Iurenev
A P
AP
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D006332:Cardiomegaly / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D004452:Echocardiography; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D007834:Lasers; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010979:Platelet Function Tests / Q000295:instrumentation / Q000379:methods
D000244:Adenosine Diphosphate
Indutsirovannaia ADF-agregatsiia trombotsitov u bol'nykh gipertonicheskoĭ bolezn'iu s razlichnoĭ stepen'iu gipertrofii miokarda levogo zheludochka.