title: Taste thresholds in patients with small-cell lung cancer.
abstract: Recognition thresholds for the four basic tastes (salt, sour, sweet and bitter) were tested by the forced-choice technique in 27 patients with small-cell lung cancer, and 22 weight-matched control patients with non-malignant diseases. No significant differences in threshold concentrations could be demonstrated. When patients who were losing weight were compared with weight-stable patients, significantly lower taste thresholds for bitter substances were found in weight losing groups in both cancer and control patients. Small-cell lung cancer patients who responded to therapy had obtained an increased threshold for bitter taste at the time of reevaluation than at the time of diagnosis, an effect that may be explained by the chemotherapeutic regimen. The results suggest that in patients with small-cell lung cancer it is not the cancer disease per se but the weight loss that often accompanies it that causes an increased taste sensitivity for bitter substances.
authors.affiliation: Department of Medicine C, Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Ovesen
authors.forename: J
authors.initials: J
authors.lastname: Hannibal
authors.forename: M
authors.initials: M
authors.lastname: Sørensen
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D013652:Taste Threshold / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents