The role of glutathione in evaluating the efficacy of antimetabolites in transplanted tumors.
Levels of glutathione (GSH) in tumor cells play an important role in determining the clinical responses to certain anticancer agents. In the present work 5-fluorouracil and 5-fluorodeoxyuridine have been used as antineoplastic agents against transplanted Ehrlich ascites carcinoma. The glutathione levels in the tumor cells and liver tissues of the host animals have been studied by a specific histofluorescence method. Significant changes have been observed in the glutathione level of the host, tumor bearing and treated group of animals, the implications of which have been discussed.
Bose
S
S
Chittaranjan National Cancer Institute, Calcutta, India.
Guha
S
S
Paul
P
P
Chowdhury
M
M
Chowdhury
S R
SR
Sen
U
U
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D002452:Cell Count; D005260:Female; D005467:Floxuridine / Q000627:therapeutic use*; D005472:Fluorouracil / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008856:Microscopy, Fluorescence; D009368:Neoplasm Transplantation
D005467:Floxuridine; D005978:Glutathione; D005472:Fluorouracil