title: Retinoic acid-induced glandular metaplasia in mouse skin is linked to the dermal expression of retinoic acid receptor beta mRNA.
abstract: The distribution of transcripts of nuclear (RAR alpha, RAR beta, and RAR gamma) and cytosolic (CRABP) retinoic acid receptors was analyzed in 13.5-day mouse embryo upper-lip skin, cultured in vitro for 48 hr with or without added retinoic acid. The results show a significant up-regulation of the transcription of the RAR beta gene concomitant with the initiation of an alteration of hair vibrissae follicle development, leading, after transfer for 8 days to the chick embryo chorioallantoic membrane, to an exocrine-type gland morphogenesis.
authors.affiliation: Centre d'Etudes et de Recherches sur les Macromolécules Organisées, Université Joseph Fourier, Grenoble, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Viallet
authors.forename: E
authors.initials: E
authors.lastname: Ruberte
authors.forename: S
authors.initials: S
authors.lastname: du Manoir
authors.forename: A
authors.initials: A
authors.lastname: Krust
authors.forename: A
authors.initials: A
authors.lastname: Zelent
authors.forename: D
authors.initials: D
authors.lastname: Dhouailly
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects; D006197:Hair / Q000166:cytology / Q000196:embryology; D008679:Metaplasia; D051379:Mice / Q000196:embryology; D009693:Nucleic Acid Hybridization; D009924:Organ Culture Techniques; D012333:RNA, Messenger / Q000235:genetics; D018168:Receptors, Retinoic Acid; D012867:Skin / Q000166:cytology; D012879:Skin Physiological Phenomena; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D002352:Carrier Proteins; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; D014212:Tretinoin