Nonspecific esterase staining of lymphocyte subsets in leprosy.
A comparative study of lymphocyte subpopulations from leprosy patients were carried out using nonspecific esterase (ANAE) staining and monoclonal antibodies. Regardless of the methodology used, an intense reduction in the total number of the T helper/inducer subset and an inversion of the helper/suppressor ration could be observed. These alterations were more evident with the progress of the disease from the tuberculoid (TL) to the lepromatous (LL) pole. Thus ANAE may be considered an economical and reliable method to be used in the study of the immune status of leprosy patients.
Macedo
H W
HW
Departamento de Patologia, Hospital Universitário Antonio Pedro, Rio de Janeiro, Brasil.
Quirico-Santos
T
T
D001402:B-Lymphocytes / Q000473:pathology; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000032:analysis*; D006801:Humans; D007918:Leprosy / Q000473:pathology*; D008214:Lymphocytes / Q000201:enzymology / Q000473:pathology*; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology
D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase