Stereoselective inhibition by D- and L-alanine of phencyclidine-induced locomotor stimulation in the rat.
Bilateral injection of D-alanine, but not L-alanine, (10-100 micrograms per side for each amino acid) into the lateral ventricle reduced the increasing effect of phencyclidine (PCP, 10 mg/kg, given intraperitoneally) on locomotor activity in the rat in a dose dependent manner. This stereoselectivity agrees with the potency of these agents as agonists for the strychnine-insensitive glycine receptor in the N-methyl-D-aspartate receptor complex, suggesting that stimulation of the allosteric regulation site may antagonize the ability of PCP to produce hyperactivity.
Tanii
Y
Y
Division of Mental Disorder Research, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Nishikawa
T
T
Hashimoto
A
A
Takahashi
K
K
D000409:Alanine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010622:Phencyclidine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000378:metabolism; D013237:Stereoisomerism; D013268:Stimulation, Chemical
D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D010622:Phencyclidine; D000409:Alanine