Conditioned reinforcing effects of 8-hydroxy-2-(di-N-propylamino) tetralin: involvement of 5-hydroxytryptamine 1A and D1 dopamine receptors.
A conditioned place preference paradigm was used to examine the motivational effects of the putative 5-hydroxytryptamine 1A (5-HT1A) receptor agonist 8-hydroxy-2-(di-n-propyl amino)tetralin (DPAT). Rats exhibited marked preferences for an environment paired with the s.c. injection of DPAT (0.1-0.25 mg/kg): vehicle injections were without effect. Pretreatment with the 5-HT1A/D2 dopamine (DA) receptor antagonist spiperone or the D1 DA receptor antagonist SCH-23390 abolished the DPAT-induced preferences. The D2 antagonist sulpiride was without effect. These data demonstrate that DPAT is an appetitive reinforcer and that this effect results from an interaction with 5-HT1A and D1 DA receptors. They further suggest that 5-HT1A agonists may have potential for abuse.
Shippenberg
T S
TS
Department of Neuropharmacology, Max-Planck Institute for Psychiatry, Martinsried, F.R.G.
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009042:Motivation; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013134:Spiperone / Q000494:pharmacology; D013469:Sulpiride / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D001552:Benzazepines; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013764:Tetrahydronaphthalenes; D013134:Spiperone; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D013469:Sulpiride