title: [Results of chromosomal studies in 270 couples with reproductive problems].
abstract: Cytogenetic study in couples with recurrent reproductive failure allows the detection of structural chromosome anomalies which don't have a phenotypic effect in carriers, but permit the explanation of the production of genetically unbalanced gametes. We present the investigation performed in 270 couples which demonstrated a chromosomal alteration in 9.2% of them. This allows genetic counselling in respect of the importance of the finding, recurrence risk and reproductive alternatives. In 8.6% we found some cellular lines with aneuploidies in sexual chromosomes, which don't represent a such concrete risk.
authors.affiliation: Departamento de Medicina, Hospital Clínico J. J. Aguirre, Universidad de Chile.
authors.forename: S
authors.initials: S
authors.lastname: Castillo
authors.forename: P
authors.initials: P
authors.lastname: Sanz
authors.forename: C
authors.initials: C
authors.lastname: Astete
authors.forename: V
authors.initials: V
authors.lastname: Daher
authors.forename: L
authors.initials: L
authors.lastname: Tobella
authors.forename: S
authors.initials: S
authors.lastname: Salazar
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D003582:Cytogenetics; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis* / Q000235:genetics; D007248:Infertility, Male / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D009030:Mosaicism / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics
vernacular_title: Rendimiento del estudio cromosómico en 270 parejas con problemas reproductivos.