title: Measurement of human cochlear blood flow.
abstract: Cochlear blood flow (CBF) was measured with a laser-Doppler (L-D) flowmeter (Periflux PR2-B) in four unanesthetized human subjects with chronic tympanic membrane perforations and nine anesthetized human subjects undergoing middle ear operations. The L-D recordings were made over the promontory and/or the round window membrane during carbogen breathing and direct electrical stimulation of the cochlea in both groups and with warm water irrigation of the external ear canal in the anesthetized subjects. Carbogen led to little or no change in CBF as monitored with either measurement approach in either subject group. Electrical stimulation yielded an increase (15% to 25%) in CBF as recorded from the promontory in seven of the nine subjects tested. Warm (44 degrees C to 49 degrees C) water irrigation produced changes of 20% to 60% in CBF that were partially recoverable in the 10 minutes available for study. This study demonstrated the feasibility of direct CBF measurement in humans with the L-D method. Moreover, the data indicate that carbogen has little influence on CBF and that electrical stimulation at relatively safe levels and warm water irrigation of the ear canal produce increases in human CBF.
authors.affiliation: Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506.
authors.forename: J M
authors.initials: JM
authors.lastname: Miller
authors.forename: G
authors.initials: G
authors.lastname: Bredberg
authors.forename: R
authors.initials: R
authors.lastname: Grenman
authors.forename: J
authors.initials: J
authors.lastname: Suonpää
authors.forename: B
authors.initials: B
authors.lastname: Lindström
authors.forename: A
authors.initials: A
authors.lastname: Didier
mesh_terms: D000368:Aged; D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology; D003051:Cochlea / Q000098:blood supply*; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D012119:Respiration; D012212:Rheology / Q000379:methods; D007507:Therapeutic Irrigation
chemical_list: D002245:Carbon Dioxide; C011700:carbogen; D010100:Oxygen