Beta-adrenergic receptor binding in frontal cortex of suicide victims.
The high-affinity binding of the beta-adrenergic receptor antagonist, [3H]dihydroalprenolol, was measured in homogenates of frontal cortex (Brodmann's areas 8 and 9) of suicide victims and matched controls. Suicides were classified as violent if gunshot, hanging, or jumping was the cause of death and as nonviolent if carbon monoxide poisoning or drug overdose was the cause of death. No significant difference were found between controls and nonviolent or violent suicide victims with regard to the number of beta-adrenergic receptors (Bmax), or the binding affinity (Kd) of the receptor. Beta-Adrenergic receptor binding was not significantly affected by sex, age, race, or postmortem interval. Serotonin-2 receptor binding (Bmax) in homogenates from the same tissue specimens was previously reported to be significantly increased in violent suicides (Arora and Meltzer 1989). In these sample groups, suicide by violent means appears to be associated with an increase in the number of serotonin-2, but not beta-adrenergic, receptors in frontal cortex.
Stockmeier
C A
CA
Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
Meltzer
H Y
HY
D000328:Adult; D000368:Aged; D002423:Cause of Death; D003866:Depressive Disorder / Q000378:metabolism; D004082:Dihydroalprenolol / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism; D013405:Suicide; D014754:Violence
D011943:Receptors, Adrenergic, beta; D011985:Receptors, Serotonin; D004082:Dihydroalprenolol