Saccharomyces cerevisiae cell cycle: cdc28 and the G1 cyclins.
Two families of cyclin-like proteins have been found in S. cerevisiae. The clb proteins are the mitotic cyclins. The cln proteins provide an essential function, are required for the G1/S transition, and appear to be rate-limiting for START, but have no obvious role elsewhere in the cycle. The cln proteins are unstable; they form complexes with cdc28; the complexes have protein kinase activity; and at least one of the clns oscillates in abundance through the cell cycle. The action of the cln cyclins at START suggests that they may be 'G1 cyclins'.
Futcher
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AB
Cold Spring Harbor Laboratory, NY 11724.
D017489:CDC28 Protein Kinase, S cerevisiae / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology; D016213:Cyclins / Q000502:physiology*; D016193:G1 Phase / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology / Q000502:physiology*
D016213:Cyclins; D017489:CDC28 Protein Kinase, S cerevisiae