title: [Prospective study of Chagas disease in newborn children with placental infection caused by Trypanosoma cruzi (Santa Cruz-Bolivia)].
abstract: In order to know the significance of placental infection by T. cruzi 820 newborn infants (NB) weighing less than or equal to 2500 grs were examined both clinically and by the Strout method and histopathological sections of the placenta in order to detect congenital infection with Chagas' disease. Thirty five (4.26%) NB presented a placentary infections by T. cruzi, but having a negative direct parasitological examination in the cord blood, these NB were followed up parasitologically (microhematocrit), in order to detect an eventual positive change in the post-partum period. The follow-up was done at 7, 15, 30 and 60 days after birth, and with xenodiagnosis 15 days later. In 27 newborn (3.29%) it was possible to complete their follow-up with detection of T. cruzi in every case. In the control group, constituted by NB which were negative to both methods, there was no positivisation at all during the follow-up period. These observations show a high frequency of congenital T. cruzi infection in Santa Cruz.
authors.affiliation: Servicio de Patología, Centro Nacional de Enfermedades Tropicales, Santa Cruz, Bolívia.
authors.forename: E
authors.initials: E
authors.lastname: Azogue
authors.forename: C
authors.initials: C
authors.lastname: Darras
mesh_terms: D001838:Bolivia; D014355:Chagas Disease / Q000151:congenital* / Q000175:diagnosis / Q000635:transmission*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010922:Placenta Diseases / Q000175:diagnosis / Q000469:parasitology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000175:diagnosis; D011446:Prospective Studies
vernacular_title: Estudio prospectivo de la enfermedad de Chagas en recién nacidos con infección placentaria por Trypanosoma cruzi (Santa Cruz-Bolivia).