Cardiac microcirculatory effects of beta-adrenergic blockade during sympathetic stimulation.
The effects of beta-adrenergic blockade on cardiac transcapillary exchange were examined at rest and during sympathetic stimulation. Multiple indicator dilution experiments were carried out in closed-chest anesthetized dogs at rest and during carotid occlusion, either under basal conditions or after beta-adrenergic blockade with alprenolol. beta-Adrenergic blockade at rest had no effect on coronary flow or transcapillary exchange in comparison with the control situation, but it abolished the increase in coronary flow and in the permeability/surface area product for labeled sucrose produced by carotid occlusion. High coronary resistance values in beta-blocked animals with carotid occlusion were associated with a high degree of heterogeneity in capillary transit times, but the overall relation between coronary flow and the capillary permeability/surface area product was unchanged. The findings indicate that beta-blockade increases coronary resistance during sympathetic stimulation and, simultaneously, decreases the coronary blood flow and capillary permeability/surface area product while increasing the heterogeneity of capillary transit times.
Cousineau
D F
DF
McGill University, Medical Clinic, Montreal General Hospital, Quebec, Canada.
Goresky
C A
CA
Rose
C P
CP
Schwab
A J
AJ
D000526:Alprenolol / Q000494:pharmacology*; D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000502:physiology*; D002339:Carotid Arteries / Q000502:physiology; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D008433:Mathematics; D008955:Models, Cardiovascular; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009412:Nerve Fibers / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism; D013395:Sucrose / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000502:physiology*; D014655:Vascular Resistance / Q000187:drug effects
D011943:Receptors, Adrenergic, beta; D012709:Serum Albumin; D013395:Sucrose; D000526:Alprenolol