8-OH-DPAT does not interfere with habituation to motion-induced emesis in cats.
Experiments were performed to determine if suppression of motion-induced emesis (motion sickness) by 8-OH-DPAT altered the development or retention of habituation to the motion stimulus. Cats received 8-OH-DPAT followed by provocative motion on three consecutive treatment days. A drug-free test on the fourth day resulted in an incidence of emesis that was not different from that obtained on the fourth consecutive day of drug-free motion testing. Three consecutive days of treatment with 8-OH-DPAT without motion had no effect on the incidence of motion sickness on the fourth day. It was concluded that suppression of motion sickness by 8-OH-DPAT does not alter the acquisition or retention of habituation.
Lucot
J B
JB
Department of Pharmacology, Wright State University, Dayton, OH 45435.
Crampton
G H
GH
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D002415:Cats; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D009041:Motion Sickness / Q000188:drug therapy / Q000503:physiopathology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology* / Q000627:therapeutic use; D014839:Vomiting
D012702:Serotonin Antagonists; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin