A simple non-surgical method of intrabronchial instillation for the establishment of respiratory infections in the rat.
A technique involving intubation of weanling rats for intrabronchial instillation of infectious material has been developed to produce a respiratory infection model suitable for experimental infection studies. The technique is performed simply with the use of a metal cannula and an intravenous plastic cannula, and dispenses with the need for illumination, laryngoscopy and extensive manipulation of the animal.
Smith
G
G
SmithKline Beecham Pharmaceuticals Research Division, Betchworth, Surrey, UK.
D000818:Animals; D003428:Cross Infection / Q000601:surgery / Q000662:veterinary*; D004195:Disease Models, Animal; D007440:Intubation; D007828:Laryngoscopy; D011014:Pneumonia / Q000382:microbiology / Q000601:surgery / Q000662:veterinary; D051381:Rats; D011919:Rats, Inbred Strains; D012141:Respiratory Tract Infections / Q000382:microbiology / Q000601:surgery / Q000662:veterinary*; D012376:Rodent Diseases / Q000382:microbiology / Q000601:surgery*; D013047:Specific Pathogen-Free Organisms; D014886:Weaning