title: Patterns of recurrence after pelvic exenteration for colorectal adenocarcinoma.
abstract: We performed a retrospective review of 68 patients who underwent pelvic exenteration for colorectal adenocarcinoma. Forty-seven patients had surgery for primary disease and 21 for recurrence. Clinical recurrence developed in 30 (44%) of 68 patients overall. Of these, 17 (57%) developed locoregional disease only as their first recurrence. This included nine (56%) of 16 patients with primary disease and eight (57%) of 14 patients with recurrent disease. Clinical recurrence developed in 16 (34%) of 47 patients with primary disease and 14 (66%) of 21 patients with recurrent disease. The overall 5-year survival rates were 43% and 20%, respectively. We conclude that locoregional recurrence remains a significant problem for primary or recurrent colorectal carcinoma even after radical pelvic surgery.
authors.affiliation: Department of Surgical Oncology and Endoscopy, Roswell Park Cancer Institute, Buffalo, NY 14263.
authors.forename: G H
authors.initials: GH
authors.lastname: Hafner
authors.forename: L
authors.initials: L
authors.lastname: Herrera
authors.forename: N J
authors.initials: NJ
authors.lastname: Petrelli
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010385:Pelvic Exenteration; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome