title: The antitumor effect of a novel nitrosourea, tauromustine, at intravenous administration in rat. Cure of hepatomas.
abstract: The effect of intravenously injected tauromustine (TCNU) on tumor growth and body weight was studied in rats with subcutaneously implanted experimental carcinomas. With a colonic tumor, a single dose or that dose split on 4 consecutive days gave the same tumor growth delay but the body weight loss was less at the split dose. Injection of the single dose for 1 min, 30 min or 2 h each had the same effect. Rats of another strain were implanted with a hepatoma. 9 out of 10 rats were cured. A late effect was body weight loss due to disturbed growth of the teeth.
authors.affiliation: Department of Pathology, Lund University, University Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Roos
authors.forename: I A
authors.initials: IA
authors.lastname: el Hag
authors.forename: P I
authors.initials: PI
authors.lastname: Christensson
authors.forename: U
authors.initials: U
authors.lastname: Stenram
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001560:Benzidines; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D004127:Dimethylhydrazines; D004354:Drug Screening Assays, Antitumor; D007275:Injections, Intravenous; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009607:Nitrosourea Compounds / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013047:Specific Pathogen-Free Organisms; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000970:Antineoplastic Agents; D001560:Benzidines; D004127:Dimethylhydrazines; D009607:Nitrosourea Compounds; D013654:Taurine; C052991:1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea