Immunisation of staff of a regional blood transfusion centre with a recombinant hepatitis B vaccine.
Medical, nursing, laboratory and other staff of the Mersey Regional Blood Transfusion Centre at risk of acquiring hepatitis B were vaccinated against the virus with a recombinant vaccine. Altogether, 86% staff developed greater than 10 mIU/ml antibody to hepatitis B virus surface antigen after immunisation but the proportion was lower in older staff. After a further injection of vaccine was given to poor and non-responders the overall proportion responding rose to 93%. The difference in response between the sexes was significant. Women had a higher rate of response and, among those persons responding, women developed a higher concentration of antibody.
Rogan
P D
PD
Mersey and North Wales Regional Blood Transfusion Centre, Mount Vernon, Liverpool, U.K.
Duguid
J K
JK
D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D005260:Female; D006268:Health Facilities; D006280:Health Workforce; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines; D006515:Hepatitis B virus / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology*; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000914:Antibodies, Viral; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines