title: A distinct potassium channel polypeptide encoded by the Drosophila eag locus.
abstract: Many of the signaling properties of neurons and other electrically excitable cells are determined by a diverse family of potassium channels. A number of genes that encode potassium channel polypeptides have been cloned from various organisms on the basis of their sequence similarity to the Drosophila Shaker (Sh) locus. As an alternative strategy, a molecular analysis of other Drosophila genes that were defined by mutations that perturb potassium channel function was undertaken. Sequence analysis of complementary DNA from the ether à go-go (eag) locus revealed that it encodes a structural component of potassium channels that is related to but is distinct from all identified potassium channel polypeptides.
authors.affiliation: Department of Zoology, University of Cambridge, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Warmke
authors.forename: R
authors.initials: R
authors.lastname: Drysdale
authors.forename: B
authors.initials: B
authors.lastname: Ganetzky
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D004330:Drosophila / Q000235:genetics*; D008969:Molecular Sequence Data; D015221:Potassium Channels / Q000235:genetics*; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid
chemical_list: D015221:Potassium Channels; D004247:DNA