title: Lysosomal enzyme activity in human aqueous humor.
abstract: Activity of the lysosomal enzymes N-acetyl-beta-D-hexosaminidase, alpha-D-mannosidase, beta-D-glucuronidase, and beta-D-galactosidase was detected in aqueous humor from eyes undergoing intraocular surgery. There was no correlation between lysosomal enzyme activity and age. Lysosomal enzyme activity in human released by ocular tissues surrounding the anterior chamber including the cornea, trabecular meshwork, ciliary body, iris, and lens. Their release into aqueous humor may have a role in regulating aqueous outflow in normal and glaucomatous eyes.
authors.affiliation: Department of Ophthalmology, University of California, San Diego 92093.
authors.forename: R N
authors.initials: RN
authors.lastname: Weinreb
authors.forename: S
authors.initials: S
authors.lastname: Jeng
authors.forename: A L
authors.initials: AL
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D001082:Aqueous Humor / Q000201:enzymology*; D005260:Female; D005696:Galactosidases / Q000378:metabolism; D005901:Glaucoma / Q000201:enzymology; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008361:Mannosidases / Q000378:metabolism; D008875:Middle Aged; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
chemical_list: D005696:Galactosidases; D008361:Mannosidases; D005966:Glucuronidase; D001619:beta-N-Acetylhexosaminidases