Humoral immune response of normal rhesus monkeys during primaquine administration.
Humoral immune response of normal rhesus monkeys was studied after giving a standard dose of primaquine. The drug did not effect the level of complement (C3) and its haemolytic activity. Levels of Immunoglobulin i.e. IgG, IgM & IgA and number of immunoglobulin secreting cells also remained unaffected. Results of this study suggested that primaquine did not suppress the immune status of the host and could be given safely to the malaria patients.
Prasad
R N
RN
Malaria Research Centre, Shahjahanpur.
Virk
K J
KJ
Ganguly
N K
NK
Mahajan
R C
RC
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003176:Complement C3 / Q000737:chemistry*; D015941:Complement Hemolytic Activity Assay; D004353:Drug Evaluation, Preclinical; D007136:Immunoglobulins / Q000097:blood*; D008213:Lymphocyte Activation / Q000187:drug effects; D008253:Macaca mulatta; D009000:Monocytes / Q000187:drug effects; D011319:Primaquine / Q000008:administration & dosage / Q000494:pharmacology*
D003176:Complement C3; D007136:Immunoglobulins; D011319:Primaquine