[Oral contraceptives and cancer of the cervix uteri. Analysis of the strength of the association].
The power of the association between oral contraceptives and cervical cancer was analysed in all the papers published up to date. Fifty-three publications (from 48 studies) wer collected and graded as to quality using meta-analytical methods. Power achieved a figure of greater than or equal to 0.8 in a 24% of the associations studied. It showed a significant relationship with the existence of a significant relative risk of the oral contraceptives for cervical cancer, with the quotient between sample sizes of reference and index groups, and with the sample size of a study, although the relationship was not linear to these two latter variables. Power did not show any significant relationship to other variables related to the design of a study, or to the biases detected. Logistic regression analysis included as predictors of a power greater than or equal to 0,80 the existence of a significant relative risk and the use of adjusted relative risk.
Rodríguez-Contreras
R
R
Departamento de Medicina Preventiva, Facultad de Medicina, Universidad de Granada.
Delgado Rodríguez
M
M
Sillero Arenas
M
M
Lardelli Claret
P
P
Gálvez Vargas
R
R
D002277:Carcinoma / Q000139:chemically induced*; D002278:Carcinoma in Situ / Q000139:chemically induced*; D015331:Cohort Studies; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016239:MEDLINE; D015201:Meta-Analysis as Topic; D012044:Regression Analysis; D002578:Uterine Cervical Dysplasia / Q000139:chemically induced; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced*
D003276:Contraceptives, Oral
Contraconceptivos orales y cáncer de cuello uterino. Análisis del poder de la asociación.