title: Orbital augmentation by hydroxylapatite-based composites. A rabbit study and comparative analysis.
abstract: Hydroxylapatite, a synthetic bone mineral, was implanted alone or as a composite with either calcium sulfate (plaster of Paris) or Avitene (microfibrillar collagen hemostatic agent) into the orbital bony defects and orbital soft tissues of 23 rabbits. Plain Avitene was also placed into these bony and soft tissue sites and bone defects with no additives served as controls. Additionally, each implant material was placed into subcutaneous tissues to determine its relative inflammatory potential. New bone formation was noted in bony defects as early as 10 days. Bone ingrowth was greatest when hydroxylapatite was in direct apposition to bone. Material implanted away from bone showed predominantly connective tissue ingrowth. Minimal inflammatory reaction was noted early on in the hydroxylapatite and hydroxylapatite/calcium sulfate samples and had resolved by 2 months when placed in both soft and bony tissues. Samples of Avitene and the hydroxylapatite/Avitene composite demonstrated an intense inflammatory response, and in several cases large granulomas were seen after 2 months.
authors.affiliation: Department of Ophthalmology, George Washington University, Washington, D.C. 20037.
authors.forename: C E
authors.initials: CE
authors.lastname: Geist
authors.forename: M A
authors.initials: MA
authors.lastname: Stracher
authors.forename: A S
authors.initials: AS
authors.lastname: Grove
mesh_terms: D000818:Animals; D002133:Calcium Sulfate; D003094:Collagen; D017886:Durapatite; D006882:Hydroxyapatites; D008422:Materials Testing; D009915:Orbit / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D019736:Prostheses and Implants; D011817:Rabbits; D013518:Surgery, Plastic / Q000295:instrumentation*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D006882:Hydroxyapatites; D003094:Collagen; D017886:Durapatite; D002133:Calcium Sulfate