[The immunofunctional properties of the cancer cells in patients with acute leukemias and the response to standard chemotherapy].
Blood and bone marrow tumor cells from 50 patients with acute leukemias (36 were with nonlymphoblastic and 14 with lymphoblastic variants) were examined in terms of cell capacity for stimulating allogeneic lymphocytes in a unidirectional mixed lymphocyte-blast culture (MLBC) and action of the PHA-induced proliferative response of donor's lymphocytes on combined 96-hour cultivation. Blast suppressors inhibiting lymphocyte stimulation in response to PHA by as much as 43-99% were not recognized by allogeneic lymphocytes in MLBC, which was not related to occasional coincidence according to HLA antigens. These patients (n = 21) turned out resistant to chemotherapy. The mechanisms of interrelations between tumor and the immunocompetent system of patients with acute leukemia and the relationship with the results of chemotherapy are discussed.
Shalaev
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VA
D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007938:Leukemia / Q000188:drug therapy / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D010835:Phytohemagglutinins
D006680:HLA Antigens; D010835:Phytohemagglutinins
Immunofunktsional'nye svoĭstva opukholevykh kletok bol'nykh ostrymi leĭkozami i otvet na sdtandartnuiu khimioterapiiu.