title: [Teratologic cranio-encephalic effects of chronic thinner inhalation in progenitors, in rats and humans].
abstract: Inhalation of thinner by youngsters and adolescents is an increasing drug abuse problem in Mexico. It presents serious repercussions upon socio-economic, cultural, legal and health (neurologic and psychiatric) problems. We report a comparative study in humans and rats which demonstrate the embryotoxic and craneo encephalic teratologic effects in the children and brood of progenitors who have chronically inhaled thinner (in the case of pregnant women, before, at the beginning and throughout pregnancy). Inhaled thinner passes directly to the blood stream and crosses the placentary barrier freely reaching the embryo. It may cause craneal bone and partial or total encephalon agenesia, added to macro and microscopic lesions secondary to direct aggression to the neuroepithelial germ cells. Abortions and premature labor with weight and size underdeveloped products and placentary hemorrhages occur. Usually these die, but if they survive they show trascendental mental retardation, as well as neurologic and psychiatric sequels.
authors.affiliation: Laboratorio de Neuromorfología Celular, Instituto Nacional de Neurología y Neurocirugía Dr. Manuel Velasco Suárez.
authors.forename: R
authors.initials: R
authors.lastname: Barroso-Moguel
authors.forename: J
authors.initials: J
authors.lastname: Villeda-Hernández
authors.forename: M
authors.initials: M
authors.lastname: Méndez-Armenta
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000015:Abnormalities, Multiple / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D001921:Brain / Q000002:abnormalities*; D005147:Facial Bones / Q000002:abnormalities*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012886:Skull / Q000002:abnormalities*; D012997:Solvents / Q000009:adverse effects*
chemical_list: D012997:Solvents
vernacular_title: Efectos teratológicos cráneo-encefálicos por inhalación crónica con thinner de los progenitores, en ratas y humanos.