A putative receptor tyrosine kinase with unique structural topology.
We have cloned a murine cDNA on the basis of homology to the tyrosine kinase domain of the bek fibroblast growth factor receptor. This cDNA encodes a putative tyrosine kinase receptor with a unique structural pattern in its extracellular domain. It is a new member of the immunoglobulin superfamily with two immunoglobulin-like domains. It also contains two fibronectin type III domains which are found on diverse proteins such as receptor tyrosine phosphatases and neural cell adhesion molecules. This protein tyrosine kinase called ark (adhesion-related kinase) is likely to represent a new class of receptor tyrosine kinase. Ark mRNA appears to be expressed in most cell lines and adult tissues examined except those of hematopoietic lineage. It is undetectable in undifferentiated teratocarcinoma cells, F9 and N Tera 2.
Rescigno
J
J
Department of Microbiology, New York University School of Medicine, New York 10016.
Mansukhani
A
A
Basilico
C
C
D000595:Amino Acid Sequence; D015342:DNA Probes; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D015513:Oncogene Proteins; D016366:Open Reading Frames; D011505:Protein-Tyrosine Kinases; D011506:Proteins / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases; D000094963:Axl Receptor Tyrosine Kinase
D015342:DNA Probes; D015513:Oncogene Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; D000094963:Axl Receptor Tyrosine Kinase