title: [Toxicologic evaluation of propyneb on the Wistar rat].
abstract: This experiment was performed in Wistar rats of both sexes exposed subchronically to 1:100, 1:500, 1:1000 and 1:1500 LD50. The evaluation was based on endpoints measured on the 30th and 90th after starting exposure and after a recovery period of 30 days: these included clinical signs, functional changes, hematological parameters, urine analysis, biochemical, histochemical, immunomorphological endpoints, electron microscopy of internal organs, chromosome examination of bone marrow. A high lethality was shown to occur with a characteristic clinical picture: interruption of weight gain, behavioural changes, leucopenia mainly involving neutrophil leucocytes, biochemical changes characteristic of liver, cardio-vascular system (myocardium and aorta) together with pathologic, biochemical, histochemical and ultrastructural changes in liver, brain, thyroid gland, myocardium, spleen and bone marrow. Endpoints were shown to be clearly dose-dependently related with small variations with the low dose, i.e. 1:1500 LD50 (5 mg/kg-1 bw).
authors.affiliation: Institut de Gastroentérologie et de Nutrition, Sofia, Bulgarie.
authors.forename: R
authors.initials: R
authors.lastname: Vachkova-Petrova
authors.forename: L
authors.initials: L
authors.lastname: Vassileva
authors.forename: G
authors.initials: G
authors.lastname: Antov
authors.forename: N
authors.initials: N
authors.lastname: Choumkov
authors.forename: N
authors.initials: N
authors.lastname: Dontchev
authors.forename: M
authors.initials: M
authors.lastname: Stavreva
authors.forename: E
authors.initials: E
authors.lastname: Tyagounenko
authors.forename: S
authors.initials: S
authors.lastname: Dinoeva
authors.forename: J
authors.initials: J
authors.lastname: Halkova
authors.forename: L
authors.initials: L
authors.lastname: Ivanova-Tchemichanska
mesh_terms: D000818:Animals; D005260:Female; D005659:Fungicides, Industrial / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015038:Zineb / Q000031:analogs & derivatives* / Q000633:toxicity
chemical_list: D005659:Fungicides, Industrial; C012509:propineb; D015038:Zineb
vernacular_title: Evaluation toxicologique du propyneb chez le rat Wistar.