Decrease in the carbamylcholine-induced chemotaxis of monocytes in myasthenia gravis.
The carbamylcholine-induced chemotaxis of monocytes was decreased in patients with myasthenia gravis, whereas no change was found in the C5a-induced locomotion of these cells compared with that of the normal controls. The decrease in the chemotaxis induced by carbamylcholine correlated with the severity of clinical symptoms. The beneficial effect of thymectomy was also reflected in the improvement of chemotaxis. The method is simple, not expensive and could be used in the diagnosis of myasthenia gravis.
Sipka
S
S
Third Department of Internal Medicine, University Medical School of Debrecen, Hungary.
Diószeghy
P
P
Mechler
F
F
Lukács
K
K
Szelényi
J
J
Szegedi
G
G
D002217:Carbachol; D002634:Chemotaxis, Leukocyte / Q000187:drug effects* / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology* / Q000601:surgery; D011950:Receptors, Cholinergic / Q000187:drug effects; D013934:Thymectomy
D011950:Receptors, Cholinergic; D002217:Carbachol