Lymphocyte antigen receptors: a common design?
A recent flurry of papers has provided detailed information on the components of the T- and B-cell antigen receptors. Although these individual elements, and the subunits they form, clearly differ, Frits Koning argues that the T- and B-cell receptor complexes may share a common underlying design.
Koning
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Dept of Immunohematology and Bloodbank, University Hospital, Leiden, The Netherlands.
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D017252:CD3 Complex; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D011487:Protein Conformation; D055503:Protein Multimerization; D011946:Receptors, Antigen / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013329:Structure-Activity Relationship
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D011946:Receptors, Antigen; D011948:Receptors, Antigen, T-Cell