Immunohistological signposts in central nervous system tumours with neuronal differentiation.
25 neuronal tumours with a panel of antibodies were studied and it was found that vimentin was present in 15 tumours. It was also found in a few cells within rosettes. PGP 9.5 showed a somatic pattern of staining with nuclear and perinuclear positivity in 23. Neurofilament reactivity was found in 14. Retinal S-antigen was detected only in one medulloblastoma, 3/4 pineal tumours and 2/2 retinoblastomas. Reactivity, for synaptophysin was present in 2/5 medulloblastomas, 3/10 neuroblastomas and 2/2 retinoblastomas. GFAP was demonstrated in scattered tumour cells in 4/5 medulloblastomas. Two of these were the only tumours featuring bipolar differentiation whilst it was unipolar in the remainder. The significance of these findings in relation to the ontogeny of these tumours is discussed.
Cruz-Sánchez
F F
FF
Department of Medicine, Provincial Hospital Clinico, University of Barcelona, Spain.
Rossi
M L
ML
Rodríguez-Prados
S
S
Cusi
V
V
Coakham
H B
HB
D000293:Adolescent; D000328:Adult; D000906:Antibodies; D000911:Antibodies, Monoclonal; D001923:Brain Chemistry; D016543:Central Nervous System Neoplasms / Q000737:chemistry*; D002648:Child; D002675:Child, Preschool; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008875:Middle Aged; D016900:Neurofilament Proteins / Q000032:analysis*; D009479:Neuropeptides / Q000032:analysis; D012160:Retina / Q000737:chemistry; D016708:Synaptophysin / Q000032:analysis; D043222:Ubiquitin Thiolesterase; D014746:Vimentin / Q000032:analysis*
D000906:Antibodies; D000911:Antibodies, Monoclonal; D005904:Glial Fibrillary Acidic Protein; D016900:Neurofilament Proteins; D009479:Neuropeptides; D016708:Synaptophysin; D014746:Vimentin; D043222:Ubiquitin Thiolesterase