[Antihypertensive efficacy of the combination of captopril 50mg and hydrochlorothiazide 25mg evaluated by ambulatory blood pressure measurement].
The anti-hypertensive effects of the captopril-hydrochlorothiazide combination administered during three months as one single morning dose were evaluated in 51 patients with moderate essential hypertension by means of ambulatory blood pressure recording. At the end of the study, the mean values of arterial blood pressure recorded over 24 hours were significantly lowered: systolic pressure was reduced from 145 +/- 11 to 131 +/- 10 mmHg (P less than 0.001), and diastolic pressure from 88 +/- 5 mmHg to 81 +/- 4 mmHg (P less than 0.001). The same results were recorded during the day (07.00 to 22.00 hours) and during the night (23.00 to 06.00 hours). No change in heart rate was observed.
Asmar
R
R
Laboratoire d'Hémodynamique cardiovasculaire, Centre de recherche de l'Hypertension artérielle, Hôpital, Broussais, Paris.
Boulanger
P
P
Benetos
A
A
Darne
B
B
Laurent
S
S
Safar
M
M
D000328:Adult; D000553:Ambulatory Care; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination / Q000379:methods; D002216:Captopril / Q000494:pharmacology; D002985:Clinical Protocols; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
D004338:Drug Combinations; D006852:Hydrochlorothiazide; D002216:Captopril
Efficacité antihypertensive de l'association captopril 50 mg et hydrochlorothiazide 25 mg par mesure ambulatoire de la pression artérielle.