Effects of granisetron and lorazepam, alone and in combination, on the EEG of human volunteers.
1. The EEG effects of granisetron, a potent and selective 5-HT3 receptor antagonist (160 micrograms kg-1), and lorazepam (2.5 mg) were examined in 12 healthy male volunteers. 2. The results indicated that lorazepam had a marked effect on the CNS, significantly increasing power in the slow (1-7 Hz) and fast (13-20 Hz; 21-30 Hz) wavebands whilst reducing power in the mid range (8-12 Hz). 3. In contrast there was no demonstrable effect of granisetron on the EEG at the dose tested, and no evidence of a pharmacodynamic interaction between the two compounds.
Link
C G
CG
Clinical Pharmacology Unit, SmithKline Beecham Pharmaceuticals, Harlow, Essex.
Leigh
T J
TJ
Fell
G L
GL
D000328:Adult; D004311:Double-Blind Method; D004347:Drug Interactions; D004569:Electroencephalography; D017829:Granisetron; D006801:Humans; D007191:Indazoles / Q000494:pharmacology*; D008140:Lorazepam / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012702:Serotonin Antagonists / Q000494:pharmacology*
D017829:Granisetron; D007191:Indazoles; D008140:Lorazepam; D012702:Serotonin Antagonists