title: Malignant peripheral nerve sheath tumor arising in a "de novo" ganglioneuroma. A case report.
abstract: A case of a "de novo" ganglioneuroma showing an internal area of malignant nerve sheath tumor is described. The tumor arose in an 18-year-old girl without a history of von Recklinghausen's disease. Immunohistochemically, the ganglioneuromatous component was positive with anti-synaptophysin, anti-S100 protein and anti-vimentin antisera, whereas the malignant part was immunoreactive only with anti-S100 protein and anti-vimentin antisera. The patient is free of disease 4 years after surgery. The clinicopathologic features of this rare case are discussed.
authors.affiliation: Institute of Anatomic Pathology, University of Bologna, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Damiani
authors.forename: V
authors.initials: V
authors.lastname: Manetto
authors.forename: G
authors.initials: G
authors.lastname: Carrillo
authors.forename: A
authors.initials: A
authors.lastname: Di Blasi
authors.forename: O
authors.initials: O
authors.lastname: Nappi
authors.forename: V
authors.initials: V
authors.lastname: Eusebi
mesh_terms: D000293:Adolescent; D002471:Cell Transformation, Neoplastic; D005260:Female; D005729:Ganglioneuroma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D009380:Neoplasms, Nerve Tissue / Q000378:metabolism / Q000473:pathology*; D009442:Neurilemmoma / Q000378:metabolism / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000378:metabolism / Q000473:pathology*