Blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in chemical workers after chloracne and in comparison groups.
Nine production workers with a history of chloracne from exposure to polychlorinated dibenzo-p-dioxins (PCDDs) in 1971-1973 had a median level of 340 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) per gram blood lipid (range 98-659 pg/g) in 1990. This was significantly higher than blood levels in 4 reference subjects without chloracne and no known exposure from the same plant (median 18, range 8-28 pg/g) and in 17 external referents (median 16, range less than 5-23 pg/g). We therefore consider chloracne to be a reliable indicator of heavy dioxin exposure in a cohort of herbicide production workers and will use its former presence in 159 cases as a substitute for exposure when investigating cancer morbidity and mortality in a multicenter cohort study.
Neuberger
M
M
Department of Preventive Medicine, University of Vienna, Austria.
Landvoigt
W
W
Derntl
F
F
D000152:Acne Vulgaris / Q000097:blood* / Q000139:chemically induced / Q000453:epidemiology; D000395:Air Pollutants, Occupational / Q000097:blood* / Q000493:pharmacokinetics / Q000506:poisoning; D001317:Austria / Q000453:epidemiology; D015331:Cohort Studies; D004196:Disease Outbreaks; D004784:Environmental Monitoring / Q000379:methods; D062665:Epidemiological Monitoring; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood* / Q000139:chemically induced / Q000453:epidemiology; D000072317:Polychlorinated Dibenzodioxins / Q000097:blood* / Q000493:pharmacokinetics / Q000506:poisoning; D012016:Reference Values
D000395:Air Pollutants, Occupational; D008055:Lipids; D000072317:Polychlorinated Dibenzodioxins