The biology of beta-adrenergic receptors: analysis in human epidermoid carcinoma A431 cells.
1. G-protein-linked transmembrane signaling has emerged as a major pathway for information transduction across the cell membrane. 2. In addition to photopigments that propagate the signal from light, cell-surface receptors for hormones, neurotransmitters, and autacoids propagate signals from ligand binding to membrane-bound effector units via G-proteins. 3. Biochemical and molecular features of one prominent member of these receptors, the beta-adrenergic receptor, will be highlighted in the present article. 4. The role of the human epidermoid carcinoma A431 cells as a model for the study of the structure and biology of beta-adrenergic receptors will be emphasized. 5. A model for receptor regulation, gleaned from recent advances in the biochemistry, cell and molecular biology of beta-adrenergic receptors, is discussed.
Wang
H Y
HY
Department of Biochemistry, National Defence Medical Center, Taipei, Taiwan, Republic of China.
Berrios
M
M
Hadcock
J R
JR
Malbon
C C
CC
D000595:Amino Acid Sequence; D000818:Animals; D006224:Cricetinae; D004814:Epidermal Cyst / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D015398:Signal Transduction; D014407:Tumor Cells, Cultured
D011943:Receptors, Adrenergic, beta; D019204:GTP-Binding Proteins