Ethanol intake and 3H-serotonin uptake. II: A study in alcoholic patients using platelets 3H-paroxetine binding.
The kinetic parameters of 3H-paroxetine binding and 3H-serotonin uptake were studied in platelets of alcoholic patients. There was no difference between alcoholic and non alcoholic subjects in 3H-paroxetine binding. When binding and 3H-serotonin uptake were studied, in the same plasma of the same subjects, the Vmax of serotonin uptake was increased in alcoholics. The data confirm the involvement of serotonin uptake system in alcohol dependence and suggest that serotonin uptake and paroxetine binding sites may be regulated independently in this pathology.
Daoust
M
M
Pharmacochimie-U.F.R. de Médecine et Pharmacie, Saint Etienne du Rouvray, France.
Lhuintre
J P
JP
Ernouf
D
D
Legrand
E
E
Breton
P
P
Boucly
P
P
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D017374:Paroxetine; D010880:Piperidines / Q000378:metabolism*; D012701:Serotonin / Q000493:pharmacokinetics*; D012702:Serotonin Antagonists / Q000378:metabolism*
D010880:Piperidines; D012702:Serotonin Antagonists; D012701:Serotonin; D017374:Paroxetine