Developmental regulation of thymosin beta 10 mRNA in the human brain.
A specific thymosin beta 10 cDNA restriction fragment was used to monitor thymosin beta 10 mRNA levels in the brain during normal human neuroembryogenesis. Northern analysis revealed a single hybridizing 600 nucleotide mRNA species which was abundant in embryonic/fetal human brain, yet absent in the adult tissue. These findings suggest that thymosin beta 10 must play an important role in early neuroembryogenesis.
Hall
A K
AK
Department of Surgery, University of Medicine and Dentistry, New Jersey Medical School, Newark 07103-2757.
D001921:Brain / Q000196:embryology*; D001923:Brain Chemistry; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D005786:Gene Expression Regulation; D006801:Humans; D012333:RNA, Messenger / Q000096:biosynthesis*; D013947:Thymosin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000235:genetics
D015342:DNA Probes; D012333:RNA, Messenger; D013947:Thymosin; C039302:thymosin beta(10); D004247:DNA