title: In vitro activity of azithromycin against clinical isolates of Legionella species.
abstract: The activities of azithromycin, erythromycin, and ciprofloxacin against 21 Legionella isolates were measured by an agar dilution method and in macrophages. The MICs for 90% of strains tested were 2.0, 1.0, and 0.5 micrograms/ml for azithromycin, erythromycin, and ciprofloxacin, respectively. Azithromycin and ciprofloxacin were both bactericidal in the macrophage system, but erythromycin was bacteriostatic.
authors.affiliation: Department of Pathology, University of Pennsylvania, School of Medicine, Philadelphia 19104-4283.
authors.forename: P H
authors.initials: PH
authors.lastname: Edelstein
authors.forename: M A
authors.initials: MA
authors.lastname: Edelstein
mesh_terms: D000818:Animals; D017963:Azithromycin; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D007875:Legionella / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D011650:Pulmonary Alveoli / Q000166:cytology
chemical_list: D004917:Erythromycin; D017963:Azithromycin