title: [Orthotopic liver transplantation for severe amanita phalloides poisoning].
abstract: Forty-eight hours after a women was poisoned by ingesting Amanita phalloides mushrooms, she developed fulminant hepatic failure with collapse, pH 7.24, lactic acidosis 7.6 mmol/l, hypoglycaemia 3.5 mmol/l, anuria and stage IV coma requiring tracheal intubation and mechanical ventilation. Transaminase level was up to 8,000 UI/l. Prothrombin and factor V levels were below 10 percent, with an APT time of 86 s versus a 29 s control time. Twenty-four hours after her admission, the patient underwent orthotopic liver transplantation. The postoperative period was uneventful, with return to consciousness and rapid normalization of hepatic biochemistry values, without signs of acute rejection. This 10th published case of orthotopic liver transplantation for Amanita phalloides poisoning with acute hepatic necrosis confirms that this type of treatment must be systematically envisaged in all such cases.
authors.affiliation: Clinique chirurgicale A, Hôpital de la Croix-Rousse, Lyon.
authors.forename: M
authors.initials: M
authors.lastname: Pouyet
authors.forename: P
authors.initials: P
authors.lastname: Caillon
authors.forename: C
authors.initials: C
authors.lastname: Ducerf
authors.forename: S
authors.initials: S
authors.lastname: Berthaud
authors.forename: Y
authors.initials: Y
authors.lastname: Bouffard
authors.forename: B
authors.initials: B
authors.lastname: Delafosse
authors.forename: A
authors.initials: A
authors.lastname: Thomasson
authors.forename: C
authors.initials: C
authors.lastname: Pignal
authors.forename: C
authors.initials: C
authors.lastname: Pulce
mesh_terms: D000545:Amanita / Q000737:chemistry; D000546:Amanitins / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D008875:Middle Aged; D009145:Mushroom Poisoning / Q000378:metabolism / Q000601:surgery* / Q000628:therapy; D010590:Phalloidine / Q000378:metabolism
chemical_list: D000546:Amanitins; D010590:Phalloidine
vernacular_title: Transplantation orthotopique du foie pour intoxication grave par amanite phalloïde.