Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers.
The concentration of total cathepsin D in cytosols of 199 node negative women with primary breast cancer in a 10-year retrospective cohort was assayed. Cathepsin D status alone was unable to predict disease-free or overall survival. However, those patients with receptor positive tumours who were cathepsin D positive had shorter [corrected] disease-free (P = 0.02) and overall survival (P = 0.01) than cathepsin D negative patients. Therefore, measurement of cathepsin D appears to provide additional prognostic information for the prediction of disease-free and overall survival in patients with node negative breast cancer.
Granata
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G
Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Coradini
D
D
Cappelletti
V
V
Di Fronzo
G
G
D001943:Breast Neoplasms / Q000737:chemistry* / Q000401:mortality; D002402:Cathepsin D / Q000032:analysis*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*; D012189:Retrospective Studies; D012307:Risk Factors
D011960:Receptors, Estrogen; D002402:Cathepsin D