title: Effect of interval between doses on response of the pony to sodium bicarbonate.
abstract: Three pony geldings were given sodium bicarbonate orally in order to study the effect on blood pH and bicarbonate and to determine if frequency of dosing influences the response. In a preliminary study, it appeared that a carry-over effect might occur if the interval between dosing was only 2 days. The ponies received 2 doses of sodium bicarbonate (400 mg/kg) 7 days apart in trial one and then in trial two they received 2 doses of sodium bicarbonate 4 days apart. The sodium bicarbonate was mixed with 2 liters of warm water and given through a nasogastric tube on each trial day. Blood samples were taken before dosing, and every half hour after for five and a half hours. The blood was analyzed for pH and bicarbonate. There did not seem to be a carry-over effect due to sodium bicarbonate administration since there was little difference in the responses between the first and second doses of each trial.
authors.affiliation: Department of Animal Science, New York State College of Agriculture, Cornell University, Ithaca 14853.
authors.forename: J
authors.initials: J
authors.lastname: Kowalski
authors.forename: A
authors.initials: A
authors.lastname: Roberts
authors.forename: J
authors.initials: J
authors.lastname: Williams
authors.forename: H F
authors.initials: HF
authors.lastname: Hintz
authors.forename: P
authors.initials: P
authors.lastname: Daniluk
authors.forename: H F
authors.initials: HF
authors.lastname: Schryver
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology*; D004334:Drug Administration Schedule; D006736:Horses / Q000097:blood*; D006863:Hydrogen-Ion Concentration; D008297:Male; D012964:Sodium / Q000008:administration & dosage / Q000494:pharmacology*; D017693:Sodium Bicarbonate; D013997:Time Factors
chemical_list: D001639:Bicarbonates; D017693:Sodium Bicarbonate; D012964:Sodium