[Retrospective analysis of the results of the treatment of children with histiocytosis].
The results of the treatment of 26 patients with histiocytosis hospitalized in the years 1970-1990 were evaluated. The age of the children at the time of diagnosis was from 4 months to 14 years, mean 32 months. In 4 cases the changes were restricted to the skeletal system, in the remaining 22 patients generalized histiocytosis was present with involvement of the skeleton and/or internal organs, and/or bone marrow. In the group with generalized histiocytosis 3 children had respiratory failure, 5 had hepatic failure, and 6 bone marrow failure. Full remission was obtained in 19 cases. Another 4 ones had persistent focal changes in the bones. Three children died of disease progression. Thus the probability of 10-year survival was for the whole group 0.86 +/- 0.13.
Januszkiewicz
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D
I Klinika Chorób Dzieci Instytutu Pediatrii, Akademii Medycznej, Poznaniu.
Nowak
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T
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage
D014747:Vinblastine; D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate
Retrospektywna analiza wyników leczenia histiocytozy u dzieci.