title: [Chronic hemorrhagic cystitis induced by cyclophosphamide in dermatomyositis refractory to corticosteroid treatment].
abstract: Dermatomyositis was diagnosed at age 7 years to a fourteen year old female. The disease was unresponsive to high doses of prednisone, so she was treated with oral cyclophosphamide 0.8 mg.kg.day (25 mg.m2) but treatment was withheld after sixteen weeks because of hemorrhagic cystitis and changed to azathioprine for two years, which resulted in complete remission of dermatomyositis. Nevertheless silent microscopic hematuria persisted and chronic cystitis was demonstrated by cystoscopy and vesical biopsy at age 13 years. In this case chronic cystitis developed earlier and at lower doses of cyclophosphamide than in other previously reported cases.
authors.affiliation: Departamento de Pediatría, Escuela de Medicina, Pontificia Universidad Católica de Chile.
authors.forename: E
authors.initials: E
authors.lastname: Talesnik
authors.forename: E
authors.initials: E
authors.lastname: Lagomarsino
authors.forename: A
authors.initials: A
authors.lastname: Gayán
authors.forename: S
authors.initials: S
authors.lastname: González
mesh_terms: D000293:Adolescent; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000009:adverse effects*; D003556:Cystitis / Q000139:chemically induced*; D003882:Dermatomyositis / Q000188:drug therapy; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D013997:Time Factors; D001745:Urinary Bladder Diseases / Q000139:chemically induced*
chemical_list: D003520:Cyclophosphamide
vernacular_title: Cistitis crónica hemorrágica por ciclofosfamida en dermatomiositis refractaria a tratamiento esteroidal.