title: Gamma interferon expression and major histocompatibility complex induction during measles and vesicular stomatitis virus infections of the brain.
abstract: Lymphocytic interferon gamma (IFN-gamma) production and major histocompatibility complex (MHC) antigen induction were studied in experimental measles and vesicular stomatitis virus infections in the brain. Fifteen-day-old Sprague-Dawley rats injected intracerebrally with the HNT strain of measles virus showed already within 1 day after infection an increased number of cells producing IFN-gamma in the spleen, cervical lymph nodes and leptomeninges. These rats recovered after a transient neuronal infection in the brain. Rats infected intracerebrally with vesicular stomatitis virus, on the other hand, all succumbed after 2 days and showed no IFN-gamma production in lymphoid cells. Immunohistochemically MHC class I antigen appeared in infected and uninfected cells in the brain during replication of both viruses. A role for the recently discovered nerve fibres with IFN-gamma-like immunoreactivity, which are normally present in the brain, in the MHC antigen induction is discussed.
authors.affiliation: Department of Cellular and Neuropathology, Huddinge Hospital, Sweden.
authors.forename: N
authors.initials: N
authors.lastname: Gogate
authors.forename: M
authors.initials: M
authors.lastname: Bakhiet
authors.forename: K
authors.initials: K
authors.lastname: Kristensson
authors.forename: E
authors.initials: E
authors.lastname: Norrby
authors.forename: T
authors.initials: T
authors.lastname: Olsson
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology; D004660:Encephalitis / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000096:biosynthesis*; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000032:analysis / Q000096:biosynthesis*; D008457:Measles / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D014721:Vesicular stomatitis Indiana virus; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D006649:Histocompatibility Antigens; D007371:Interferon-gamma