Long-term haemodynamic effects of amlodipine at rest and during exercise in essential hypertension.
Amlodipine administered once daily (5-10 mg) lowered blood pressure and reduced total peripheral resistance in patients with mild-to-severe essential hypertension without any reflex tachycardia. Heart pump function was maintained at rest and during exercise with a trend towards an increase in cardiac and stroke index. Amlodipine was effective and well tolerated in both young and elderly hypertensive patients with no reports of unpleasant vasodilator-related side effects.
Lund-Johansen
P
P
Medical Department, Section of Cardiology, Haukeland Hospital, Bergen, Norway.
Omvik
P
P
White
W
W
Digranes
O
O
Helland
B
B
Jordal
O
O
Stray
T
T
D000328:Adult; D017311:Amlodipine; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005082:Physical Exertion / Q000502:physiology*; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D002121:Calcium Channel Blockers; D017311:Amlodipine; D009543:Nifedipine