Sequence and expression of a metabotropic glutamate receptor.
The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.
Masu
M
M
Institute for Immunology, Kyoto University, Faculty of Medicine, Japan.
Tanabe
Y
Y
Tsuchida
K
K
Shigemoto
R
R
Nakanishi
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002531:Cerebellum / Q000378:metabolism; D003001:Cloning, Molecular; D004594:Electrophysiology / Q000379:methods; D005260:Female; D005971:Glutamates / Q000378:metabolism / Q000494:pharmacology*; D008961:Models, Structural; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D009865:Oocytes / Q000187:drug effects / Q000502:physiology; D011487:Protein Conformation; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D051381:Rats; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D012689:Sequence Homology, Nucleic Acid; D014981:Xenopus
D005971:Glutamates; D012333:RNA, Messenger; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter