title: [Efficacy in viral inactivation of the concentrates of factor VIII and IX by the solvent/detergent procedure. Evaluation in patients with hemophilia].
abstract: Human immunodeficiency virus (HIV) infection and hepatitis virus B or C (HBV, HCV) transmission are major risks following infusion of coagulation factor concentrates. Thus, several methods have been used to achieve viral inactivation of concentrates prepared from plasma collected from a large number of donors. In this study, 32 patients with haemophilia A or B (n = 31) or von Willebrand's disease (n = 1) were treated between 1987 and 1990 only with factor VIII or IX concentrates inactivated by the solvent-detergent procedure. During this period, none of these cases exhibited elevated liver enzymes (alanine amino transferase), and serological tests for HIV, HBV and HCV infections always remained negative. This suggests that the solvent-detergent procedure of concentrate inactivation is an efficient method to prevent not only HIV or HBV transmission but also HCV infection in haemophiliacs.
authors.affiliation: Centre de traitement de l'hémophilie, Hôpital Trousseau, Tours.
authors.forename: C
authors.initials: C
authors.lastname: Guerois
authors.forename: A
authors.initials: A
authors.lastname: Parquet
authors.forename: M
authors.initials: M
authors.lastname: Vicariot
authors.forename: F F
authors.initials: FF
authors.lastname: Lecoeur
authors.forename: P
authors.initials: P
authors.lastname: Maisonneuve
authors.forename: A M
authors.initials: AM
authors.lastname: Courouce
authors.forename: F
authors.initials: F
authors.lastname: Dubois
authors.forename: Y
authors.initials: Y
authors.lastname: Laurian
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003902:Detergents; D005069:Evaluation Studies as Topic; D005164:Factor IX / Q000494:pharmacology* / Q000627:therapeutic use; D005169:Factor VIII / Q000494:pharmacology* / Q000627:therapeutic use; D006467:Hemophilia A / Q000628:therapy*; D006801:Humans; D007223:Infant; D008722:Methods; D012189:Retrospective Studies; D012997:Solvents; D014779:Virus Replication / Q000187:drug effects*; D014842:von Willebrand Diseases / Q000628:therapy*
chemical_list: D003902:Detergents; D012997:Solvents; D005169:Factor VIII; D005164:Factor IX
vernacular_title: Efficacité de l'inactivation virale des concentrés de facteur VIII et IX par procédé solvant-détergent. Evaluation chez l'hémophile.