title: [A comparison of the effect of tranquilizers in experiments and clinical practice].
abstract: Experimental and clinical study of the analgesic effects of mebicar and benzodiazepine series tranquilizers (sibazon and chlozepid) and their combinations with non-narcotic analgesics (amidopyrin, pyranal) or local anesthetic lidocaine has demonstrated a more marked effect of benzodiazepine derivatives on pain sensitivity thresholds as against mebicar. Tranquilizer combinations with other analgesics helped define the optimal premedication variants: benzodiazepine derivative augment analgesic activity whereas mebicar potentiates lidocaine effect.
authors.forename: E V
authors.initials: EV
authors.lastname: Zorian
authors.forename: L I
authors.initials: LI
authors.lastname: Larentsova
authors.forename: G M
authors.initials: GM
authors.lastname: Aleksandrova
authors.forename: N V
authors.initials: NV
authors.lastname: Novikova
mesh_terms: D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy; D011817:Rabbits; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects; D014098:Toothache / Q000188:drug therapy; D014149:Tranquilizing Agents / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D014149:Tranquilizing Agents; D008012:Lidocaine
vernacular_title: Sravnenie éffekta trankvilizatorov v éksperimente i klinicheskoĭ praktike.