Cooperation of Co(III) complex and cyclodextrin for prompt and regioselective hydrolysis of ribonucleoside 2',3'-cyclic monophosphates at pH 7.
2',3'-Cyclic phosphates of guanosine and adenosine (G greater than p and A greater than p), the simplest intermediates in RNA hydrolysis, are regioselectively and promptly hydrolyzed at pH 7, 30 degrees C by combination of [Co(tme)2(H2O)2]3+ complex and cyclodextrins: tme (1,1,2,2-tetramethylethylenediamine). Both the selectivity and the reaction rate are largely increased by cooperation of these two catalysts.
Matsumoto
Y
Y
Institute of Materials Science, University of Tsukuba, Ibaraki, Japan.
Komiyama
M
M
D003035:Cobalt / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012265:Ribonucleotides / Q000737:chemistry*
D003505:Cyclodextrins; D005029:Ethylenediamines; D009942:Organometallic Compounds; D012265:Ribonucleotides; C077800:diaquabis(1,1,2,2-tetramethylethylenediamine)cobalt(III); D003035:Cobalt