Clinical significance of IgG subclasses of Anti-Sm and U1 ribonucleoprotein antibodies in patients with systemic lupus erythematosus and mixed connective tissue disease.
IgG subclasses of anti-Sm and anti-U1 ribonucleoprotein (U1 RNP) antibodies were determined using a new clone of the anti-IgG2 antibody (HG2-56F). Although the predominance of IgG1 coincided with previous reports, IgG2 anti-Sm and U1 RNP antibodies were detected in numerous patients. IgG3 anti-Sm antibody significantly correlates with joint involvement and a high titer of anti-DNA antibody. On the other hand, IgG4 anti-U1 RNP antibody significantly correlated with esophageal dilation and muscular involvement. These results may suggest that some IgG subclasses are related to a specific clinical feature or manifestation.
Tokano
Y
Y
Department of Internal Medicine, Juntendo University, School of Medicine, Tokyo, Japan.
Yasuma
M
M
Harada
S
S
Takasaki
Y
Y
Hashimoto
H
H
Okumura
K
K
Hirose
S
S
D001323:Autoantibodies / Q000145:classification*; D001324:Autoantigens; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008947:Mixed Connective Tissue Disease / Q000276:immunology*; D012261:Ribonucleoproteins / Q000276:immunology; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins
D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins