A newly discovered xenobiotic metabolic pathway: ethyl ester formation.
Formation of etretinate, ethyl ester of acitretin, can be confirmed in vitro and in vivo using acitretin as the substrate. Etretinate was identified by LC/MS. The in vitro incubation was performed using rat and human liver 12,000 g supernatant, and the in vivo experiment was conducted in rats after oral dosing of acitretin. The ethyl ester formation was greatly enhanced by addition of or dosing with ethanol.
Chou
R C
RC
Pharmaceutical Research, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Wyss
R
R
Huselton
C A
CA
Wiegand
U W
UW
D017255:Acitretin; D000818:Animals; D004951:Esterification / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D005050:Etretinate / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D051381:Rats; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000378:metabolism
D000431:Ethanol; D014212:Tretinoin; D005050:Etretinate; D017255:Acitretin