[Prospective study of mortality among women and its relation to the main risk factors].
The data obtained in the prospective study of females aged 20-69 years in one of the Leningrad districts made in possible to assess the role of basic risk factors of cardiovascular diseases (CCV) as predictors of death. For females, arterial hypertension was not found to be a significant risk factor for CCV mortality. Among lipid fractions, elevated levels of low density lipoprotein (LDL) cholesterol was demonstrated to hold the lead (the risk ratio, 3.6), high levels of triglycerides occupied the second place (the risk ratio, 1.88, and the content of total cholesterol occupied the third place (the risk ratio, 1.7). Low body weight was the major protective factor in females. Following 5 years of the primary survey, the cumulative cancer mortality continued to increase in individuals having low cholesterol levels, which opposes the supposition that low cholesterol concentrations are a marker of an existing tumor process. The CCV mortality-total cholesterol level relationship was demonstrated to be prone to u-dependence, i.e. a deviation from average cholesterol levels towards the both directions is an unfavorable factor and requires that a clinicist be more careful.
Plavinskaia
S I
SI
Shestov
D B
DB
D000328:Adult; D000368:Aged; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000401:mortality*; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000209:etiology / Q000401:mortality*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications*; D006973:Hypertension / Q000150:complications*; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012426:Russia; D012737:Sex Factors
D008078:Cholesterol, LDL
Smertnost' sredi zhenshchin v prospektivnom issledovanii i ee vzaimosviaz' s osnovnymi faktorami riska.