Hepatocellular carcinoma as second malignant neoplasms in successfully treated Wilms' tumor patients. A National Wilms' Tumor Study report.
Although rare, second malignant neoplasms (SMN) after treatment for Wilms' tumor are deadly. A recent National Wilms' Tumor Study (NWTS) report identified 15 patients with second malignancies discovered over 14,381 person-years of observation. This report described four patients with secondary hepatocellular carcinoma in greater detail. These patients were strikingly similar in that all had right-sided tumors and each one had received right upper-quadrant irradiation. All patients died shortly after diagnosis of the SMN.
Kovalic
J J
JJ
Washington University School of Medicine, St. Louis, Missouri.
Thomas
P R
PR
Beckwith
J B
JB
Feusner
J H
JH
Norkool
P A
PA
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000628:therapy; D008113:Liver Neoplasms / Q000209:etiology*; D008297:Male; D009378:Neoplasms, Multiple Primary; D009396:Wilms Tumor / Q000150:complications* / Q000628:therapy