title: [Comparative analysis between the circumoval precipitin test and ELISA with raw antigens for the diagnosis of schistosomiasis in Venezuela].
abstract: Schistosomiasis has special characteristics in Venezuela, since the majority of the infected population is asymptomatic and the elimination of eggs is very low, difficulting in this way parasitologic diagnosis. It is thus necessary to develop sensitive and specific immunologic methods to be applied in field surveys. The present study compares two serologic tests for Schistosomiasis, the enzyme linked immunosorbent assay (ELISA) with eggs (SEA) and adult (AWA) antigens and the traditional circumoval precipitation test (COPT). Sensitivity and specificity of the test were performed being 100% and 92% in COPT, 79% and 71% in ELISA-SEA and 71% and 91% in ELISA-AWA respectively. Advantages and disadvantages of each test are discussed.
authors.affiliation: Instituto de Medicina Tropical, Universidad Central de Venezuela.
authors.forename: L
authors.initials: L
authors.lastname: Spencer
authors.forename: B
authors.initials: B
authors.lastname: Alarcón de Noya
authors.forename: O
authors.initials: O
authors.lastname: Noya
authors.forename: G
authors.initials: G
authors.lastname: Masroua
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005243:Feces / Q000469:parasitology; D006801:Humans; D008875:Middle Aged; D011233:Precipitin Tests / Q000379:methods*; D051381:Rats; D012550:Schistosoma mansoni / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology; D012680:Sensitivity and Specificity; D014687:Venezuela / Q000453:epidemiology
vernacular_title: Análisis comparativo entre la prueba de precipitación circumoval y ELISA con antígenos crudos para el diagnóstico de la esquistosomiasis en Venezuela.