title: IgM-associated primary diffuse mesangial proliferative glomerulonephritis: natural history and prognostic indicators.
abstract: Fifty-four adults with primary mesangial proliferative glomerulonephritis and IgM deposition were observed for a minimum of three years or until end-stage renal failure. The actuarial renal survival was 80 per cent at 5 years and 64 per cent at 10 years; multivariate analysis identified microscopic haematuria, extent of mesangial proliferation and global glomerular sclerosis as independent prognostic indicators.
authors.affiliation: Renal Unit, Manchester Royal Infirmary.
authors.forename: D J
authors.initials: DJ
authors.lastname: O'Donoghue
authors.forename: W
authors.initials: W
authors.lastname: Lawler
authors.forename: L P
authors.initials: LP
authors.lastname: Hunt
authors.forename: E J
authors.initials: EJ
authors.lastname: Acheson
authors.forename: N P
authors.initials: NP
authors.lastname: Mallick
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis; D012008:Recurrence
chemical_list: D007075:Immunoglobulin M; D011239:Prednisolone