Affinity and concentration of anti-HIV antibodies in asymptomatic and symptomatic HIV infection.
A novel method based on dose-response curve of antibodies and employing a hyperbolic function for its description was used for the assessment of the affinity and concentration of anti-HIV antibodies in eighteen anti-HIV positive males. The patients were followed up for a period of 8 months to 5 years and affinity and concentration of antibodies were measured at least twice, at the beginning and at the end of the observation period. No correlation between antibodies affinity and the clinical stage of infection was observed, however, concentration of antibodies decreased rapidly in AIDS.
Radkowski
M
M
Department of Immunopathology, Institute of Infectious and Parasitic Diseases, Warszawa, Poland.
Laskus
T
T
Goch
A
A
Slusarczyk
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D000915:Antibody Affinity; D000937:Antigen-Antibody Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D015483:HIV Antibodies / Q000032:analysis / Q000276:immunology*; D006679:HIV Seropositivity; D006801:Humans; D008297:Male; D008875:Middle Aged
D015483:HIV Antibodies