Protective immunity in pig-tailed macaques after cervical infection with Chlamydia trachomatis.
Seven pig-tailed macaques were inoculated in the cervix with Chlamydia trachomatis. Cervical infection resulted in all animals. After spontaneous cessation of cervical shedding of C. trachomatis, repeated inoculation either failed to produce infection, or resulted in infection of shorter duration with lower inclusion counts. Thus, cervical infection may lead to protective local immunity in pig-tailed macaques.
Wolner-Hanssen
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P
Department of Obstetrics and Gynecology, University of Washington, Seattle 98195.
Patton
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DL
Holmes
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KK
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D002584:Cervix Uteri / Q000382:microbiology; D002690:Chlamydia Infections / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000254:growth & development / Q000276:immunology* / Q000302:isolation & purification; D015169:Colony Count, Microbial; D005260:Female; D007074:Immunoglobulin G / Q000032:analysis; D010535:Laparoscopy; D008254:Macaca nemestrina; D002575:Uterine Cervicitis / Q000276:immunology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G