title: [Synthesis and structure elucidation of single and multiple thionated barbituric acid derivatives].
abstract: Merbarone [5-(N-phenylcarboxamido)-2-thiobarbituric acid] was developed to clinical trial stage on the basis of its curetive activity against P388 and L1210 leukemias. In the present paper the synthesis of new thioanalogues of pento- and hexobarbital is described. All new compounds were characterized by their spectroscopic data.
authors.affiliation: Institut für Pharmazie, Johannes Gutenberg-Universität Mainz.
authors.forename: J
authors.initials: J
authors.lastname: Stratmann
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013858:Thiobarbiturates / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013858:Thiobarbiturates
vernacular_title: Synthese und Strukturaufklrung einfach und mehrfach thionierter Barbitursäurederivate.