Roles of interleukin-1 and tumor necrosis factor in lipopolysaccharide-induced hypoglycemia.
In this study, hypoglycemia induced by injection of lipopolysaccharide (LPS) or the recombinant cytokine interleukin-1 alpha or tumor necrosis factor alpha (administered alone or in combination) was compared. LPS-induced hypoglycemia was reversed significantly by recombinant interleukin-1 receptor antagonist.
Vogel
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SN
Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
Henricson
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BE
Neta
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R
D000818:Animals; D005260:Female; D007003:Hypoglycemia / Q000139:chemically induced*; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000502:physiology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D011506:Proteins / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors; D017472:Receptors, Interleukin-1; D011994:Recombinant Proteins / Q000494:pharmacology; D012795:Sialoglycoproteins; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
C507764:Il1rn protein, mouse; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D008070:Lipopolysaccharides; D011506:Proteins; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; D011994:Recombinant Proteins; D012795:Sialoglycoproteins; D014409:Tumor Necrosis Factor-alpha