Impetigo herpetiformis associated with hypocalcemia of congenital rickets.
A 30-year-old woman with congenital rickets and autosomal recessive ichthyosis developed impetigo herpetiformis in the second trimester of her first pregnancy. This condition was temporally related to her discontinuation of vitamin D supplements and subsequent hypocalcemia. No associated systemic symptoms were observed, and a healthy baby was delivered prematurely at 34 weeks' gestation. This report supports the association between hypocalcemia and impetigo herpetiformis and raises theoretical questions regarding a relationship between vitamin D metabolism and various epidermal hyperproliferative states.
Holm
A L
AL
Department of Dermatology, University of Rochester School of Medicine, NY 14642.
Goldsmith
L A
LA
D000328:Adult; D003874:Dermatitis Herpetiformis / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000150:complications*; D007015:Hypophosphatemia, Familial / Q000150:complications / Q000151:congenital*; D011247:Pregnancy; D011248:Pregnancy Complications