Antidotal effects of dimercaptosuccinic acid.
Dimercaptosuccinic acid (DMS), HOOC-CH(SH)-CH(SH)-COOH, was first developed in China as an effective antidote for poisoning from many heavy metals, such as Pb, Hg, As, Cd, Sb, Tl, Au, Zn, Ni, Pt, Ag, Co and Sn. DMS increases the excretion of Ce, Pm, Sr and Po from the body. Hundreds of patients suffering from hepatolenticular degeneration (Wilson's disease) have been treated successfully with DMS. Recently, DMS was found to be effective also in treating certain non-metallic intoxications, like some of the new non-phosphate pesticides and mushroom poisonings.
Ding
G S
GS
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China.
Liang
Y Y
YY
D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D006801:Humans; D008670:Metals / Q000506:poisoning; D011041:Poisoning / Q000188:drug therapy; D004113:Succimer / Q000494:pharmacology* / Q000633:toxicity
D000931:Antidotes; D008670:Metals; D004113:Succimer