title: Effects of atrial natriuretic peptide on adrenergically induced norepinephrine release and vasoconstriction in the dog kidney.
abstract: The effects of atrial natriuretic peptide (ANP) on the neural control of renal blood flow were examined in anesthetized dogs. Intrarenal arterial infusion of ANP (alpha-hANP, 10 and 50 ng/kg per min) suppressed the decrease in renal blood flow but not the increase in renal venous plasma norepinephrine concentration induced by renal nerve stimulation (1 and 2 Hz, for 1 min). ANP also attenuated the blood flow response to intrarenal arterial injection of methoxamine (5-20 micrograms). These results suggest that ANP acts at a postsynaptic site to suppress adrenergically induced vasoconstriction in the dog kidney.
authors.affiliation: Department of Pharmacology, Tohoku University, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tomura
authors.forename: T
authors.initials: T
authors.lastname: Yamagata
authors.forename: H
authors.initials: H
authors.lastname: Hisa
authors.forename: S
authors.initials: S
authors.lastname: Satoh
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism / Q000494:pharmacology*; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000294:innervation; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism*; D012079:Renal Circulation / Q000187:drug effects* / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D009320:Atrial Natriuretic Factor; D008729:Methoxamine; D009638:Norepinephrine