[Pharmacologic analysis of the effect of gamma-D-glutamylglycine on kainate and quisqualate receptors].
gamma-D-Glutamylglycine (DGG) influence on kainate- and quisqualate-activated currents in the Purkinje neurons from rat cerebellum was investigated. DGG caused a parallel shift of concentration dependences of kainate-activated current and a transient component of quisqualate-activated current to the right. Concentration dependence of the stationary component of quisqualate-activated current was shifted to the right by DGG and simultaneously its cooperativity decreased.
Marchenko
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D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D007608:Kainic Acid / Q000494:pharmacology*; D011689:Purkinje Cells / Q000187:drug effects; D016318:Quisqualic Acid / Q000494:pharmacology*; D051381:Rats; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter / Q000187:drug effects*
D004151:Dipeptides; D007608:Kainic Acid; D016318:Quisqualic Acid; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter; C028929:gamma-glutamylglycine
Farmakologicheskiĭ analiz deĭstviia gamma-D-glutamilglitsina na retseptory kainata i kviskvalata.