[Plasma homocysteine assay in the exploration of thrombosis in young subjects].
Homocystinuria is a rare inherited metabolic disease transmitted as an autosomal recessive trait. Arterial and venous thromboembolic events are frequent and life-threatening complications in homocystinuric patients. It has been suggested that mild homocysteinemia could be a risk factor for vascular disease. We measured total plasma L-homocysteine concentrations by radioisotopic assay in 32 subjects with arterial (n = 15) or venous (n = 17) thrombosis. Twelve subjects exceeded the upper normal limit (2.70 SD above the mean), i.e. 14.1 mumol/l. Seven had arterial thrombotic disease and five had deep vein thrombosis. In 18 subjects thrombosis developed in the absence of any of the hitherto recognized risk factors; 6 of these subjects had mild homocysteinemia. Thus, homocysteine metabolism must be investigated in patients with thromboembolism. An increase of homocysteinemia could be a risk factor for thromboembolic events, and the possible benefit of vitamin therapy should be discussed.
Bienvenu
T
T
Laboratoire de Biochimie Génétique, Hôpital Necker, Paris.
Ankri
A
A
Chadefaux
B
B
Kamoun
P
P
D000293:Adolescent; D000328:Adult; D005260:Female; D006710:Homocysteine / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay; D012016:Reference Values; D012307:Risk Factors; D013924:Thrombophlebitis / Q000097:blood*; D013927:Thrombosis / Q000097:blood*
D006710:Homocysteine
Dosage de l'homocystéine plasmatique dans l'exploration des thromboses du sujet jeune.