An inositol phosphoglycan stimulates glycolysis in human platelets.
Upon hydrolysis of membrane glycosyl-phosphatidylinositol (gly-PtdIns), an inositol phosphoglycan (IPG) is generated, responsible for multiple biological activities and recently proposed as mediator of the action of a variety of hormones and growth factors. The present study shows that IPG is able to significantly stimulate platelet glycolysis, which represents the major energy producing pathway in this cell system. The activation of glycolytic flux induced by IPG appears to be specific and very rapid even though the molecular mechanism involved remains to be elucidated.
Bruni
P
P
Dipartimento di Scienze Biochimiche, Università di Firenze, Italy.
Vasta
V
V
Berti
L
L
Avila
M A
MA
Farnararo
M
M
Varela-Nieto
I
I
D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D005635:Fructosediphosphates / Q000097:blood; D005958:Glucosephosphates / Q000097:blood; D006017:Glycolipids / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects*; D017261:Glycosylphosphatidylinositols; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D007773:Lactates / Q000097:blood; D010716:Phosphatidylinositols / Q000494:pharmacology*; D013917:Thrombin / Q000494:pharmacology
D005635:Fructosediphosphates; D005958:Glucosephosphates; D006017:Glycolipids; D017261:Glycosylphosphatidylinositols; D007773:Lactates; D010716:Phosphatidylinositols; C027652:fructose 2,6-diphosphate; C031590:glucose-1-phosphate; D013917:Thrombin; C029063:fructose-1,6-diphosphate