[Consideration on the mechanism of liver regeneration on experimental results].
Liver has enough functional capacity and regeneration ability. Liver parenchymal cells are usually stable, and it is thought being at stage of Go in cell cycle. But liver cells are easily into progressive stage and the liver recovers its functions and volume after partial hepatectomy or liver injury. Usually the studies of liver regeneration are done by studying control of growth of isolated hepatocytes in primary culture in vitro, and by pathological considerations of experimental injured models of liver in vivo. In this paper, we considered known several hepatotrophic factors including our experimental results, and regeneration mechanisms by noticing appearance of albumin positive hepatocytes in injured Nagase analbuminemic rat (NAR).
Niiya
M
M
Department of Internal Medicine I, Jikei University School of Medicine, Tokyo, Japan.
Hasumura
S
S
Nagamori
S
S
D000375:Aging / Q000473:pathology; D000418:Albumins / Q000378:metabolism; D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D005109:Extracellular Matrix; D006133:Growth Substances / Q000502:physiology; D006498:Hepatectomy; D017228:Hepatocyte Growth Factor; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology; D008099:Liver / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D008106:Liver Cirrhosis, Experimental / Q000473:pathology / Q000503:physiopathology; D008115:Liver Regeneration
D000418:Albumins; D006133:Growth Substances; D015850:Interleukin-6; D017228:Hepatocyte Growth Factor; D004247:DNA