Synovial fluid immunocytology in the diagnosis of leukemic synovitis.
We describe a patient with leukemic synovitis complicating acute lymphoplastic leukemia. Leukemic cells were identified in the synovial fluid by an indirect immunofluorescent technique using monoclonal antibodies against early B cell antigens. Since focal leukemic lesions may be missed in synovial biopsy specimens, immunocytological analysis of joint fluids may facilitate early diagnosis of leukemic arthritis.
Fam
A G
AG
Department of Medicine, Sunnybrook Health Science Centre, University of Toronto, ON, Canada.
Voorneveld
C
C
Robinson
J B
JB
Sheridan
B L
BL
D000328:Adult; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D000943:Antigens, Differentiation / Q000032:analysis / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D015260:Neprilysin; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000473:pathology; D013582:Synovial Fluid / Q000737:chemistry / Q000166:cytology* / Q000276:immunology; D013585:Synovitis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D015260:Neprilysin