Fibroblast growth factor receptors from liver vary in three structural domains.
Changes in heparin-binding fibroblast growth factor gene expression and receptor phenotype occur during liver regeneration and in hepatoma cells. The nucleotide sequence of complementary DNA predicts that three amino-terminal domain motifs, two juxtamembrane motifs, and two intracellular carboxyl-terminal domain motifs combine to form a minimum of 6 and potentially 12 homologous polypeptides that constitute the growth factor receptor family in a single human liver cell population. Amino-terminal variants consisted of two transmembrane molecules that contained three and two immunoglobulin-like disulfide loops, as well as a potential intracellular form of the receptor. The two intracellular juxtamembrane motifs differed in a potential serine-threonine kinase phosphorylation site. One carboxyl-terminal motif was a putative tyrosine kinase that contained potential tyrosine phosphorylation sites. The second carboxyl-terminal motif was probably not a tyrosine kinase and did not exhibit the same candidate carboxyl-terminal tyrosine phosphorylation sites.
Hou
J Z
JZ
W. Alton Jones Cell Science Center, Inc., Lake Placid, NY 12946.
Kan
M K
MK
McKeehan
K
K
McBride
G
G
Adams
P
P
McKeehan
W L
WL
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D006801:Humans; D008099:Liver / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000502:physiology*; D017468:Receptors, Fibroblast Growth Factor; D011975:Receptors, Mitogen / Q000502:physiology*; D040262:Receptors, Vascular Endothelial Growth Factor; D014407:Tumor Cells, Cultured
D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D011975:Receptors, Mitogen; D004247:DNA; D011505:Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor