Synthesis and structure-activity relationships of a series of substituted-phenylpropionic acids as a novel class of leukotriene B4 antagonists.
Konno
M
M
Minase Research Institute, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Sakuyama
S
S
Nakae
T
T
Hamanaka
N
N
Miyamoto
T
T
Kawasaki
A
A
D000818:Animals; D001667:Binding, Competitive; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D010666:Phenylpropionates / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D011971:Receptors, Immunologic / Q000378:metabolism; D018102:Receptors, Leukotriene B4; D013329:Structure-Activity Relationship
D010666:Phenylpropionates; D011971:Receptors, Immunologic; D018102:Receptors, Leukotriene B4; C067523:ONO-LB 457; D007975:Leukotriene B4