title: Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid.
abstract: This study evaluates the modulation of striatum vulnerability to quinolinic acid (QA) by the nitrostriatal projection. Unilateral lesioning of the substantia nigra with 6-hydroxydopamine markedly reduced the volume of striatal necrosis observed 3 days after local injection of quinolinic acid (150 nmol). This result is consistent with the concept that the nigrostriatal pathway potentiates the vulnerability of striatum to excitotoxic damage.
authors.affiliation: Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Buisson
authors.forename: V
authors.initials: V
authors.lastname: Pateau
authors.forename: M
authors.initials: M
authors.lastname: Plotkine
authors.forename: R G
authors.initials: RG
authors.lastname: Boulu
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000166:cytology / Q000187:drug effects*; D003891:Desipramine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects; D009434:Neural Pathways / Q000187:drug effects; D016627:Oxidopamine / Q000494:pharmacology; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000166:cytology / Q000187:drug effects*
chemical_list: D011805:Quinolinic Acids; D016627:Oxidopamine; D017378:Quinolinic Acid; D003891:Desipramine; D004298:Dopamine