title: Angiofollicular lymph node hyperplasia and peripheral neuropathy. Case report and literature review.
abstract: A man with multicentric angiofollicular lymph node hyperplasia and a polyclonal gammopathy developed a debilitating sensory-motor peripheral neuropathy that resolved with plasma-pheresis and immunosuppressive therapy. Fourteen similar cases have been reported in the literature; however, to our knowledge, this is the first report of successful treatment with plasma-pheresis. Severe peripheral neuropathy usually occurs in the setting of multicentric, plasma cell-type disease with hypergammaglobulinemia and is often responsive to immunosuppressive therapy.
authors.affiliation: Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Md. 20889.
authors.forename: B
authors.initials: B
authors.lastname: Scherokman
authors.forename: S J
authors.initials: SJ
authors.lastname: Vukelja
authors.forename: E
authors.initials: E
authors.lastname: May
mesh_terms: D000368:Aged; D001379:Azathioprine / Q000627:therapeutic use; D005871:Castleman Disease / Q000150:complications*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000628:therapy; D010956:Plasmapheresis; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D001379:Azathioprine; D011241:Prednisone