[Effects of PN 200-110 on penicillin-induced epileptic activity in the cerebral cortex of rats].
In experiments on freely moving Wistar rats it was shown that an intraperitoneal administration of PN 200-110 in a dose of 2 mg/kg in the period of steady epileptic activity (EpA) with regular generation of ictal discharges in penicillin--induced focus resulted in suppression of EpA in most animals. Antiepileptic effect of the drug was manifested by decreasing frequency appearance of ictal discharges and shortening of the epileptic focus existence time. Intraperitoneal administration (5 mg/kg) and intraventricular injection (10 nmol) of PN 200-110 20 min before the epileptic focus formation resulted in an increased latency period of appearance interictal discharges and decreased number of ictal discharges, and shortening of the existence time of epileptic focus.
Kryzhanovskiĭ
G N
GN
Karpova
M N
MN
Pankov
O Iu
OIu
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000503:physiopathology*; D017275:Isradipine; D008297:Male; D010069:Oxadiazoles / Q000494:pharmacology*; D010406:Penicillins; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002121:Calcium Channel Blockers; D010069:Oxadiazoles; D010406:Penicillins; D017275:Isradipine
Vliianie PN 200-110 na penitsillinindutsirovannuiu épilepticheskuiu aktivnost' v kore golovnogo mozga krys.