title: Single-dose trospectomycin for chlamydial urethritis in men.
abstract: Trospectomycin is an aminocyclitol analog of spectinomycin with significant in vitro activity against Chlamydia trachomatis. A single 1-g intramuscular dose was administered to 10 men with symptomatic, culture-positive chlamydial urethritis. Trospectomycin was well tolerated but failed to eradicate chlamydial infection, as determined by cultures obtained approximately 1 week after treatment.
authors.affiliation: Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642.
authors.forename: M C
authors.initials: MC
authors.lastname: Keefer
authors.forename: M A
authors.initials: MA
authors.lastname: Menegus
authors.forename: M A
authors.initials: MA
authors.lastname: Nasello
authors.forename: J A
authors.initials: JA
authors.lastname: Reid
authors.forename: M
authors.initials: M
authors.lastname: Long
authors.forename: R C
authors.initials: RC
authors.lastname: Reichman
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D000198:Spectinomycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014526:Urethritis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents; C043267:trospectomycin; D000198:Spectinomycin