title: [Subacute and subchronic oral toxicity of beta-bis carboxyethyl sesquioxide of germanium in the rat].
abstract: After a brief recall of toxicological data about germanium compounds, the authors relate subacute and subchronic oral toxicities of beta bis carboxyethyl-germanium sesquioxide in rats. During 28 days and six months, male and female animals have received 1 mg/kg/day. No particular toxic symptoms, no behaviour trouble except a small decrease of body weight, in male rats, at the end of the 6-month experimentation, were observed. A light decrease of erythropoiesis and a general stimulation of cellular metabolism has been noticed after 28 days. The only marked effect was a moderate renal deficiency characterized by a tubular disease with presence of cylinders, swelling of tubulus cells and floculus amounts after 6 months. Germanium urinary excretion was constant and linked to the received dose. Six months later, no preferential accumulation in organs was observed.
authors.affiliation: Laboratoire de Toxicologie, UFR des Sciences Pharmaceutiques et Biologiques, Rennes, France.
authors.forename: F
authors.initials: F
authors.lastname: Anger
authors.forename: J P
authors.initials: JP
authors.lastname: Anger
authors.forename: L
authors.initials: L
authors.lastname: Guillou
authors.forename: P A
authors.initials: PA
authors.lastname: Sado
authors.forename: A
authors.initials: A
authors.lastname: Papillon
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005260:Female; D005857:Germanium; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000633:toxicity*; D011422:Propionates; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D009942:Organometallic Compounds; D011422:Propionates; D005857:Germanium; C066750:propagermanium
vernacular_title: Toxicités orales subaiguë et sub chronique du beta-bis carboxyéthyl sesquioxyde de germanium, chez le rat.