[The significance of oxidized lipoproteins for the development of atherosclerosis. Antioxidants as a therapeutic alternative in atherosclerosis].
Hypercholesterolemia is a major risk factor of coronary heart disease, and treatment aimed at reducing the circulating cholesterol level is essential in preventing lipid depositions in the arterial wall. Increasing evidence supports the hypothesis that plasma lipoproteins must be modified before they can be taken up and degraded by macrophages in the arterial wall intima to such an extent that these cells accumulate lipids. Oxidation is probably an important mechanism in this modification. Oxidized low density lipoproteins (LDL) may be atherogenic in several ways. Antioxidant therapy delays the development of atherosclerosis in animal experiments and may become a future alternative in the treatment of atherosclerosis. The article describes the main conclusions in recent research which may clarify the mechanisms of the atherogenic effect of cholesterol-rich lipoproteins.
Boberg
K M
KM
Klinisk-kjemisk avdeling, Rikshospitalet, Oslo.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D008078:Cholesterol, LDL / Q000097:blood*; D006801:Humans; D010084:Oxidation-Reduction; D012307:Risk Factors
D000975:Antioxidants; D008078:Cholesterol, LDL
Betydningen av oksiderte lipoproteiner for ateroskleroseutvikling. Antioksidanter som behandlingsalternativ ved aterosklerose.