Murine candidiasis: sex differences in the severity of tissue lesions are not associated with levels of serum C3 and C5.
Mice deficient in the fifth component of complement are known to be extremely susceptible to lethal challenge with Candida albicans. However, male mice, that have significantly higher concentrations of serum C5 than females, were markedly more susceptible to infection. This difference was observed in both susceptible (CBA/H) and resistant (BALB/c) mice. Levels of serum C3 likewise showed no correlation with susceptibility.
Ashman
R B
RB
Department of Pathology, University of Western Australia, Nedlands.
Kay
P H
PH
Lynch
D M
DM
Papadimitriou
J M
JM
D000818:Animals; D002177:Candidiasis / Q000276:immunology* / Q000473:pathology; D003176:Complement C3 / Q000032:analysis*; D003182:Complement C5 / Q000032:analysis*; D005260:Female; D006461:Hemolysis / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D012727:Sex Characteristics; D013047:Specific Pathogen-Free Organisms
D003176:Complement C3; D003182:Complement C5