title: [131I]metaiodobenzylguanidine therapy in carcinoid tumors.
abstract: Our experience with [131I]metaiodobenzylguanidine (131I-MIBG) therapy in two patients with carcinoid tumor is described. These patients were selected because of multiple areas of uptake on 131I-MIBG scan, consistent with the extent of the disease. Both patients presented diarrhea and liver metastases. Para-aortical lymphonodes and skeletal metastases were present in the first and the second patient, respectively. Previous treatment involved r-alpha-interferon, surgery or radiotherapy. In both cases 131I-MIGB therapy was started in December 1990 and is still continuing. No haematologic or hepatic side-effects have been observed. Mild hypotension (90/60 mmHg) occurred in one patient during the first course of therapy and was resolved by corticoid treatment. A stabilization of disease and a progressive reduction of diarrhea have been observed in both patients. In the second patient an initial decrease in liver metastases was confirmed by ultrasonography 7 months after the beginning of therapy.
authors.affiliation: Division of Nuclear Medicine, National Cancer Institute, Milan, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Castellani
authors.forename: M
authors.initials: M
authors.lastname: Di Bartolomeo
authors.forename: L
authors.initials: L
authors.lastname: Maffioli
authors.forename: N
authors.initials: N
authors.lastname: Zilembo
authors.forename: M
authors.initials: M
authors.lastname: Gasparini
authors.forename: G L
authors.initials: GL
authors.lastname: Buraggi
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary* / Q000628:therapy; D002276:Carcinoid Tumor / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000556:secondary* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine