Suppression of lymphokine production in anti-minor histocompatibility antigen responses.
Allogeneic immunizations between mice strains that differ at multiple loci coding for minor histocompatibility antigens (mha) result in a variety of immune responses, including the induction of cytotoxic T cells, helper T cells, and delayed hypersensitivity reactions. However, high-dose intravenous immunization induces a population of cells that can suppress these responses. In this paper, we show that the transfer of this suppressor population in vivo is accompanied by a reduced ability of immune cells to produce the two lymphokines interleukin-2 (IL-2) and interleukin-3 (IL-3). In a different assay of suppressor function, suppressor cells were co-cultured with responder cells in vitro. Under these conditions, the presence of suppressor cells resulted in a lowered net production of IL-2, but not IL-3. Possible mechanisms for this phenomenon are discussed.
Yin
L
L
Department of Biology, University College London, UK.
Chain
B M
BM
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D007114:Immunization; D007376:Interleukin-2 / Q000032:analysis / Q000096:biosynthesis* / Q000494:pharmacology; D007377:Interleukin-3 / Q000032:analysis / Q000096:biosynthesis* / Q000494:pharmacology; D008198:Lymph Nodes / Q000276:immunology; D008212:Lymphocyte Depletion; D008222:Lymphokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D015778:Minor Histocompatibility Antigens / Q000276:immunology*; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007376:Interleukin-2; D007377:Interleukin-3; D008222:Lymphokines; D015778:Minor Histocompatibility Antigens