Anti-anginal efficacy of intravenous amlodipine assessed by means of atrial pacing.
The anti-anginal efficacy of amlodipine was investigated in patients with angina pectoris by means of atrial pacing during cardiac catheterization. Intravenous administration of amlodipine significantly increased the time to pacing-induced angina and reduced the area of ST-segment change for an equivalent pacing rate, suggesting an improvement in this functional marker of ischaemia. In addition, a significant reduction in the double product suggests that amlodipine reduced myocardial oxygen consumption.
Hogg
K J
KJ
Department of Materia Medica, Stobhill General Hospital, Glasgow, UK.
Hornung
R S
RS
Hillis
W S
WS
Gupta
S
S
Grant
P
P
Singh
S P
SP
D017311:Amlodipine; D000787:Angina Pectoris / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D006801:Humans; D007275:Injections, Intravenous; D009543:Nifedipine / Q000008:administration & dosage / Q000031:analogs & derivatives*
D002121:Calcium Channel Blockers; D017311:Amlodipine; D009543:Nifedipine