[Influence of protein S deficiency on the arterial thrombosis risk].
Protein S is the cofactor of activated protein C which, together with the antithrombin system, is a major regulator of coagulation. Congenital protein S deficiency is an important risk factor for venous thrombosis. In this study of 105 patients with protein S deficiency, 64 had one of several thromboembolic accidents, including 14 arterial thrombotic accidents involving the central nervous system or the myocardium. These accidents occurred in young subjects (mean age: 25 +/- 13 years) only one-third of whom had another risk factor. This high frequency of arterial thrombosis associated with protein S deficiency calls for a prospective study in young subject with cerebral vascular accident or myocardial infarction.
Wiesel
M L
ML
Service d'Hémostase et de Thrombose, INSERM U311, CRTS, Strasbourg.
Borg
J Y
JY
Grunebaum
L
L
Vasse
M
M
Levesque
H
H
Bierme
R
R
Sie
P
P
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006023:Glycoproteins / Q000172:deficiency*; D006801:Humans; D007122:Immunoelectrophoresis; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D017293:Protein S; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology*
D006023:Glycoproteins; D017293:Protein S
Influence du déficit constitutionnel en protéine S sur le risque thrombotique artériel.