L-asparaginase--a reassessment.
The authors review some historical data connected with the discovery of the enzyme l-asparaginase and then summarize the basic informations concerning the mechanism of action, clinical application, toxicity and future prospectives of this substance. From the clinical viewpoint, a broader use of l-asparaginase prepared from Erwinia carotovora instead of Escherichia coli seems to be warranted.
Krc
I
I
1st Clinic of Internal Medicine, Medical Faculty, Palacký University, Olomouc, Czechoslovakia.
Krcová
V
V
D001215:Asparaginase / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000188:drug therapy
D001215:Asparaginase