title: [Necrotizing extracapillary glomerulonephritis without immunoglobulin deposits. Renal localization of systemic vasculitis with anti-cytoplasm polynuclear antibodies].
abstract: Necrotizing and crescentic glomerulonephritis without immunoglobulin deposits (also called pauci-immune glomerulonephritis) is the cause of approximately 50 percent of acute renal failures of glomerular origin. Our study, based on 40 case-records selected on histological criteria, and on data from the literature, shows that in most cases, if not all, this type of glomerulonephritis is part of a wider systemic vasculitis which predominantly affects the glomerular capillaries. Anti-neutrophil cytoplasm antibodies are detected in three-quarters of the cases, with a specific distribution that varies according to the clinical features. In spite of the patients' age (mean: 62 years), the severity of glomerular lesions and the extra-renal diffusion of the disease, 60 percent of these patients can be cured and recover a normal, or at least acceptable renal function, provided the corticosteroid and sometimes immunosuppressive therapy is initiated at an early stage.
authors.affiliation: Service de Néphrologie, Hôpital Tenon, Paris.
authors.forename: P
authors.initials: P
authors.lastname: Bindi
authors.forename: B
authors.initials: B
authors.lastname: Mougenot
authors.forename: F
authors.initials: F
authors.lastname: Mentre
authors.forename: L H
authors.initials: LH
authors.lastname: Noel
authors.forename: M N
authors.initials: MN
authors.lastname: Peraldi
authors.forename: P
authors.initials: P
authors.lastname: Vanhille
authors.forename: P
authors.initials: P
authors.lastname: Lesavre
authors.forename: F
authors.initials: F
authors.lastname: Mignon
authors.forename: P
authors.initials: P
authors.lastname: Ronco
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis*; D003593:Cytoplasm / Q000276:immunology*; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007674:Kidney Diseases / Q000175:diagnosis / Q000188:drug therapy; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology* / Q000473:pathology; D011379:Prognosis; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000305:Adrenal Cortex Hormones; D000906:Antibodies; D007166:Immunosuppressive Agents
vernacular_title: Glomérulonéphrite extracapillaire nécrosante sans dépôts d'immunoglobuline. Localisation rénale d'une vasculite systémique avec anticorps anti-cytoplasme des polynucléaires.