title: Ki-67 staining in histological subtypes of breast carcinoma and fine needle aspiration smears.
abstract: Thirty four cases of invasive breast carcinoma were analysed for heterogeneity of Ki-67 reactivity in a tumour, and proliferative activity in various histological subtypes was compared. The growth factions determined in areas of central and peripheral tumour were the same. Mucinous and lobular carcinoma showed lower Ki-67 activity than ductal carcinomas. When ductal carcinomas were subdivided according to their dominant growth pattern, the carcinomas with a solid or comedo growth pattern showed the highest proliferative activity. These results largely confirm data from previous cell kinetic studies on the incorporation of radioactively labelled thymidine. A correlation between the growth fraction determined by Ki-67 in fine needle aspiration smears and cryostat sections of corresponding tumours was shown, implying that the immunostaining of cytological smears gives a reliable impression of the growth fraction of a tumour and may therefore be used in prospective studies.
authors.affiliation: Department of Pathology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
authors.forename: V
authors.initials: V
authors.lastname: Kuenen-Boumeester
authors.forename: T H
authors.initials: TH
authors.lastname: Van Der Kwast
authors.forename: H A
authors.initials: HA
authors.lastname: Van Laarhoven
authors.forename: S C
authors.initials: SC
authors.lastname: Henzen-Logmans
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000276:immunology; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000276:immunology; D002455:Cell Division; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen; D009687:Nuclear Proteins / Q000032:analysis* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D019394:Ki-67 Antigen; D009687:Nuclear Proteins