[Radiosensitivity of marrow stromal cells and the effect of some radioprotective agents].
The results showed that marrow stromal cells include fibroblasts, reticular cells, macrophages and adipocytes. The capability of the adherent layer derived from marrow cells of 2 mouse femurs to support hematopoietic stem cells was stronger than those of layers derived from 0.5 or 1 mouse femurs. The radiosensitivity of bone marrow stromal cells was lower than that of hematopoietic stem cells. The radioprotective effect of AET and PLP (polysaccharide of Lobaria pulmonaria Hoffm) on the bone marrow stromal cells and their capability to support hematopoietic stem cells was clearly demonstrated.
Liu
S
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Institute of Radiation Medicine, Tianjin.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D005260:Female; D006412:Hematopoietic Stem Cells / Q000528:radiation effects; D008011:Lichens / Q000737:chemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011134:Polysaccharides / Q000494:pharmacology*; D011836:Radiation Tolerance / Q000187:drug effects*; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology*
D011134:Polysaccharides; D000338:beta-Aminoethyl Isothiourea