The syndrome of ophthalmoplegia, ataxia and areflexia (Fisher's syndrome): clinical analysis of 9 cases.
From January 1976 through December 1988, 9 patients with clinical manifestations of the syndrome of ophthalmoplegia, ataxia and areflexia were diagnosed at National Taiwan University Hospital. Among them, 2 patients experienced recurrent attacks. A total of 12 attacks were recorded. Preceding symptoms of upper respiratory tract infection were noted in 9 out of 12 attacks. A spectrum of neuro-ophthalmological manifestations was observed. Most of these findings were probably secondary to central nervous system involvement. An elevation of protein level without pleocytosis was found in CSF examination of 6 attacks. Electrodiagnostic studies suggested large myelinated sensory fibers involvement as the major finding in 5 patients. A benign course in all 9 patients was noted. Special attention to nosological position and unusual features are also discussed.
Yip
P K
PK
Department of Neurology, National Taiwan University Hospital, Taipei, R.O.C.
Tsai
S Y
SY
Chen
R C
RC
D000293:Adolescent; D000328:Adult; D001259:Ataxia / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D009886:Ophthalmoplegia / Q000503:physiopathology*; D011129:Polyradiculoneuropathy / Q000503:physiopathology*; D012018:Reflex; D013577:Syndrome