[Cytogenetic studies in renal carcinoma].
We have analyzed from cytogenetic point of view 24 cases of sporadic renal carcinoma. Clonal chromosome changes were found in 15 of 24 cases (62.5%) (-Y, +7, +10, del (3) (p21----pter), der (1). For what in concerning correlations between Karyotype and anatomo-pathological and clinical aspects we can observe that: 1) Cases with normal Karyotype showed low grade of anaplasia and stage I 2) No correlation exists between karyotype and diameter of the neoplasia. In 8 cases cytogenetic analysis was performed in normal renal tissue; five case showed the same clonal abnormality present in the correspondent neoplasia (-Y, +18, +10); one case showed trisomy 7. The result are discussed in respect to the previous literature and to the clinical significance.
Casalone
R
R
Biologia Gen e Genetica Medica-Università di Pavia.
Bono
A V
AV
Pozzi
C
C
Granata
P
P
D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D003582:Cytogenetics; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics*
Indagini citogenetiche nei carcinomi renali.