Urodilatin, a kidney-derived natriuretic factor, is excreted with a circadian rhythm and is stimulated by saline infusion in man.
Urodilatin is a recently described, presumably kidney-derived member of the atrial natriuretic peptide family. The first data on a physiological role for urodilatin in the regulation of sodium homeostasis in humans is presented in this work. Urinary urodilatin excretion during a 9-day study in healthy volunteers paralleled the circadian rhythm in urinary sodium excretion. Furthermore, urodilatin and sodium excretion were slightly increased during the first 3 h after an acute isotonic saline infusion and about three-fold elevated during 14 h postinfusion; both parameters remained closely correlated up to 28 h postinfusion. These data suggest that urodilatin is involved in the circadian regulation of sodium excretion and is a physiological regulator of long-term sodium excretion after an acute saline infusion.
Drummer
C
C
Medizinische Klinik, Klinikum Innenstadt der Universität, München, Federal Republic of Germany.
Fiedler
F
F
König
A
A
Gerzer
R
R
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000652:urine*; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000502:physiology; D008297:Male; D009318:Natriuresis / Q000502:physiology; D010446:Peptide Fragments / Q000652:urine*; D012965:Sodium Chloride / Q000008:administration & dosage
D010446:Peptide Fragments; D012965:Sodium Chloride; C056452:Ularitide; D009320:Atrial Natriuretic Factor