The role of peroxidases in the activation of chemical carcinogens.
Peroxidases exhibit a wide substrate specificity with respect to various carcinogenic xenobiotics. Peroxidase-mediated activations of several carcinogenic polycyclic aromatic hydrocarbons, aromatic amines, phenols, azo dyes and N-nitrosamines are reviewed, considering their possible involvement in the initiation of chemical carcinogenesis. Activation pathways of these carcinogens examined in vitro, in subcellular fractions, cell cultures and in vivo are evaluated.
Stiborová
M
M
Department of Biochemistry, Faculty of Natural Sciences, Charles University, Prague, Czechoslovakia.
Frei
E
E
Schmeiser
H H
HH
Anzenbacher
P
P
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000493:pharmacokinetics*; D006801:Humans; D010544:Peroxidases / Q000378:metabolism*; D015262:Xenobiotics / Q000493:pharmacokinetics
D002273:Carcinogens; D015262:Xenobiotics; D010544:Peroxidases