Inhibition of I-A expression in rat peritoneal macrophages due to T-suppressor cells induced by Cryptococcus neoformans.
The expression of I-A antigen in rat peritoneal cells was significantly reduced during infection with Cryptococcus neoformans. When studying the in vitro action of T-suppressor cells induced by the fungus, or a soluble factor from the T-suppressor cells, a significant decrease in I-A expression by the peritoneal cells was observed. This expression was partially restored by indomethacin.
Masih
D T
DT
Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina.
Sotomayor
C E
CE
Cervi
L A
LA
Riera
C M
CM
Rubinstein
H R
HR
D000818:Animals; D003453:Cryptococcosis / Q000276:immunology*; D003455:Cryptococcus neoformans / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D007213:Indomethacin / Q000494:pharmacology; D008264:Macrophages / Q000276:immunology*; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D007213:Indomethacin