title: Antibodies to toluene diisocyanate in patients with and without dialysis anaphylaxis.
abstract: In a majority of patients with anaphylaxis to dialysis, ethylene oxide has been identified as an etiologic agent. In a significant minority of patients sustaining such reactions, the antigen remains unidentified. Conflicting results have been published with regard to isocyanates as a possible antigen. The authors studied 19 hemodialysis patients with anaphylaxis in whom IgE against ethylene oxide-human serum albumin (ETO-HSA) was not identified (Group 1) and 25 peritoneal dialysis patients without anaphylaxis (Group 2). IgE against toluene diisocyanate-human serum albumin (TDI-HSA) was found in one patient in Group 1, and a similar incidence of IgG against TDI-HSA in Group 1 (16%) and Group 2 (12%) was noted. The results do not suggest that IgE against TDI-HSA is an important cause of dialysis anaphylaxis.
authors.affiliation: Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.
authors.forename: L C
authors.initials: LC
authors.lastname: Grammer
authors.forename: K E
authors.initials: KE
authors.lastname: Harris
authors.forename: M A
authors.initials: MA
authors.lastname: Shaughnessy
authors.forename: J
authors.initials: J
authors.lastname: Dolovich
authors.forename: R
authors.initials: R
authors.lastname: Patterson
authors.forename: S
authors.initials: S
authors.lastname: Evans
mesh_terms: D000707:Anaphylaxis / Q000209:etiology / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D010530:Peritoneal Dialysis; D006435:Renal Dialysis / Q000009:adverse effects*; D014051:Toluene 2,4-Diisocyanate / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E