Inhibition of bone marrow immature B lymphocytes from zinc deficient mice by methionine enkephalin.
Bone marrow cells (BMC) from Zn deficient mice were used to measure the anti-TNP plaque forming cell (PFC) response in the presence of methionine enkephalin (Met-Enk). The results demonstrated that the PFC response of BMC was suppressed by Met-Enk. In the case of Zn deficient group, the inhibitions were up to 51% compared to 27% for the control and became higher as the increasing concentration of Met-Enk. It seems that the sensitivity to Met-Enk was related to degree of Zn deficiency. These findings suggest that Zn may interfere with the role of Met-Enk on BMC.
Li
G
G
Department of Biochemistry, Xi'an Medical University, China.
Yu
J
J
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D001853:Bone Marrow / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D005260:Female; D006462:Hemolytic Plaque Technique; D051379:Mice; D015032:Zinc / Q000172:deficiency*
D004744:Enkephalin, Methionine; D015032:Zinc