Glycoprotein synthesis and secretion. Expression of fibronectin and its cell surface receptors.
Fibronectin (FN) is an extracellular matrix protein that acts as a substrate for cell migration and adhesion during development. Cells adhere to FN through integral membrane proteins that are members of the integrin family of adhesion molecules. The interaction between cells and FN is important in a number of biologic processes, including gastrulation, hematopoietic differentiation, neural crest cell migration, cardiac development, branching morphogenesis in lung, wound healing, tumorigenesis, and metastasis. Expression of FN and its receptors is controlled by a number of hormones and growth factors as well as by tissue-specific factors. Here, the molecular aspects of how expression of these genes is controlled are reviewed, with particular emphasis on promoter regulator elements that modulate expression.
Dean
D C
DC
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Birkenmeier
T M
TM
Rosen
G D
GD
Weintraub
S J
SJ
D005353:Fibronectins / Q000235:genetics*; D006023:Glycoproteins / Q000096:biosynthesis* / Q000378:metabolism*; D006801:Humans; D011401:Promoter Regions, Genetic / Q000235:genetics; D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic / Q000235:genetics*
D005353:Fibronectins; D006023:Glycoproteins; D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic