title: Toxicological study of the molluscicidal latex of Euphorbia splendens: irritant action on skin and eye.
abstract: Aqueous solutions of the molluscicidal latex of Euphorbia splendens are irritant to the rabbit eye in concentrations higher than 0.35% and to the rabbit skin in concentrations higher than 0.5%. Although this irritant potential does not preclude its use as a molluscicide, special precautions are recommended for handling and application of the product and the hazard of skin tumor-promoting potential should be carefully investigated before its use for schistosomiasis vector control.
authors.affiliation: Instituto Nacional de Controle de Qualidade em Saúde, Departamento de Farmacologia e Toxicologia, Rio de Janeiro, Brasil.
authors.forename: J C
authors.initials: JC
authors.lastname: Freitas
authors.forename: O A
authors.initials: OA
authors.lastname: Presgrave
authors.forename: F F
authors.initials: FF
authors.lastname: Fingola
authors.forename: M A
authors.initials: MA
authors.lastname: Menezes
authors.forename: M C
authors.initials: MC
authors.lastname: Vasconcellos
authors.forename: V T
authors.initials: VT
authors.lastname: Schall
authors.forename: F J
authors.initials: FJ
authors.lastname: Paumgartten
mesh_terms: D000818:Animals; D003231:Conjunctivitis / Q000139:chemically induced*; D003877:Dermatitis, Contact / Q000209:etiology*; D004487:Edema / Q000139:chemically induced; D004890:Erythema / Q000139:chemically induced; D007509:Irritants / Q000633:toxicity*; D007840:Latex / Q000633:toxicity*; D008975:Molluscacides / Q000633:toxicity*; D011817:Rabbits
chemical_list: D007509:Irritants; D007840:Latex; D008975:Molluscacides