Molecular structure of the Japanese hepatitis C viral genome.
The amino acid sequence of the polyprotein deduced from the nucleotide sequence of the Japanese hepatitis C virus genome (N. Kato et al. (1990) Proc. Natl. Acad. Sci. USA 87, 9524-9528) indicated that this virus is a member of a new class of positive-stranded RNA viruses. Several domains of this polyprotein also showed weak homology with those of flaviviruses and pestiviruses including the chymotrypsin-like serine proteinase, NTPase and RNA-dependent RNA polymerase.
Kato
N
N
Virology Division, National Cancer Center Research Institute, Tokyo, Japan.
Hijikata
M
M
Nakagawa
M
M
Ootsuyama
Y
Y
Muraiso
K
K
Ohkoshi
S
S
Shimotohno
K
K
D000595:Amino Acid Sequence; D002918:Chymotrypsin / Q000737:chemistry / Q000235:genetics; D005416:Flavivirus / Q000235:genetics; D016174:Hepacivirus / Q000235:genetics*; D008969:Molecular Sequence Data; D043583:Nucleoside-Triphosphatase; D010576:Pestivirus / Q000235:genetics; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry / Q000235:genetics; D012324:RNA-Dependent RNA Polymerase / Q000737:chemistry / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D012995:Solubility; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics*
D014764:Viral Proteins; D012324:RNA-Dependent RNA Polymerase; D010744:Phosphoric Monoester Hydrolases; D002918:Chymotrypsin; D043583:Nucleoside-Triphosphatase