title: [Improvement in nuclear medicine diagnosis of kidney function using 99m technetium mercaptoacetyltriglycine (MAG3)].
abstract: Renal scintigraphy and clearance measurement are indispensable in nephro-urologic disorders. A continuous series of 103 sequential scintigraphies and clearance measurements were performed with the new technetium-labelled agent MAG3 (Gamma-kamera, Phillips Tomo Diagnost) and 131I-orthohippuric acid (OIH) using the Oberhausen method (Nucleopan, Siemens). The time-activity curves obtained with the two radionuclides agreed exactly. Reaching a tubular excretion rate of nearly 90%, the clearance of MAG3 differed by no more than 6% from the OIH clearance in 95% of the cases. The factor between clearances of the two radionuclides was determined by means of a commercially available software according to the Oberhausen method and amounted to 0.59 +/- 0.09. The favorable physical properties and high activity of MAG3 permit exact examination of tubular function and better assessment of renal morphology than hippuran-labelled radionuclides. The low radiation dose combined with a better spatial resolution, especially, the constant availability in a nuclear medicine department should give the preference to MAG3.
authors.affiliation: Abteilung Urologie, Bundeswehrzentralkrankenhaus Koblenz.
authors.forename: K
authors.initials: K
authors.lastname: Erpenbach
authors.forename: A
authors.initials: A
authors.lastname: Ebert
authors.forename: H
authors.initials: H
authors.lastname: Wieler
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007465:Iodohippuric Acid; D007669:Kidney Calculi / Q000000981:diagnostic imaging; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000000981:diagnostic imaging; D009842:Oligopeptides; D015609:Organotechnetium Compounds; D011704:Pyelonephritis / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D017263:Technetium Tc 99m Mertiatide
chemical_list: D009842:Oligopeptides; D015609:Organotechnetium Compounds; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide
vernacular_title: Verbesserung der nuklearmedizinischen Nierenfunktionsdiagnostik durch den Einsatz von 99m-Technetiummercaptoacetyltriglycin (MAG3).