Intracellular sodium activity in papillary muscle from diabetic rat hearts.
In quiescent papillary muscles isolated from hearts of rats with streptozotocin-induced diabetes resting intracellular sodium activity (aiNa) was about 56% greater than in muscles from controls. An intracellular acid load induced by the NH4+ method caused a rise in aiNa whose maximum amplitude was similar in both groups of muscles. However, the half-time to maximum amplitude was increased by about 56% in diabetic muscles. These results are consistent with a diabetes-induced decrease in the activity of the sarcolemmal Na(+)-H+ exchange.
Lagadic-Gossmann
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Laboratoire de Physiologie et Métabolisme Cellulaires, URA CNRS 1121, Université Paris XI, Orsay, France.
Feuvray
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D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006859:Hydrogen / Q000378:metabolism; D066298:In Vitro Techniques; D007474:Ion Exchange; D008297:Male; D010210:Papillary Muscles / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*; D017923:Sodium-Hydrogen Exchangers
D002352:Carrier Proteins; D017923:Sodium-Hydrogen Exchangers; D006859:Hydrogen; D012964:Sodium