title: Changes in plasmaconcentration of ANP and aldosterone in normal pregnancy and pregnancy complicated by pre-eclampsia.
abstract: Changes in plasmaconcentration of ANP in normal pregnancy and pregnancy complicated by pre-eclampsia were examined and compared to non-pregnant controls. The maternal plasma concentration increased gradually during normal pregnancy but values did not deviate significantly from non-pregnant women. A further increase was demonstrated post partum. In pre-eclampsia maternal plasma ANP levels increased significantly compared with normal gravida at the same gestational age and non-pregnant controls. After delivery ANP decreased significantly. Non correlation between ANP and aldosterone were found in either normal pregnancy nor pregnancy complicated by pre-eclampsia. It is not yet clear how important ANP is for the regulation of blood pressure and sodium and water balance during normal pregnancy and pregnancy complicated by pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Hvidrove Hospital, University of Copenhagen, Denmark.
authors.forename: A L
authors.initials: AL
authors.lastname: Mikkelsen
authors.forename: G
authors.initials: G
authors.lastname: Schütten
authors.forename: U
authors.initials: U
authors.lastname: Asping
authors.forename: H J
authors.initials: HJ
authors.lastname: Schütten
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011262:Pregnancy Trimester, Second / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor