Drug-induced reductions in ethanol intake in alcohol preferring and Fawn-Hooded rats.
The ethanol intake of Fawn-Hooded rats, a serotonin deficient strain, was examined under a two bottle choice between ethanol (10%) and tap water. The Fawn-Hooded rats drank as much ethanol as the alcohol preferring strain of rats (approximately 6 times that of the control Wistar rats), but drank more fluid and ate more. In general, direct and indirect serotonin agonists, reduced ethanol intake to a smaller degree in the Fawn-Hooded rats compared to the P rats. In contrast the centrally acting antimuscarinic scopolamine reduced ethanol intake to a similar degree in the two strains.
Rezvani
A H
AH
Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill 27599.
Overstreet
D H
DH
Janowsky
D S
DS
D000428:Alcohol Drinking / Q000517:prevention & control*; D000437:Alcoholism / Q000235:genetics / Q000517:prevention & control*; D000818:Animals; D002065:Buspirone / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage; D005247:Feeding Behavior / Q000187:drug effects; D005473:Fluoxetine / Q000494:pharmacology; D008297:Male; D010869:Pindolol / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D012601:Scopolamine / Q000494:pharmacology*; D012646:Self Administration; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013045:Species Specificity; D014700:Verapamil / Q000494:pharmacology
D010879:Piperazines; D017366:Serotonin Receptor Agonists; D005473:Fluoxetine; D000431:Ethanol; D010869:Pindolol; D014700:Verapamil; D012601:Scopolamine; C015068:1-(3-chlorophenyl)piperazine; D002065:Buspirone