Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat.
Wedge
S R
SR
Department of Biological Sciences, University of Keele, UK.
Duncan
R
R
Kopeckova
P
P
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003630:Daunorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005688:Galactosamine / Q000378:metabolism*; D007275:Injections, Intravenous; D007424:Intracellular Fluid / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D011109:Polymethacrylic Acids / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000378:metabolism*; D014316:Tritium; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
D011109:Polymethacrylic Acids; C055174:daunomycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugate; D014316:Tritium; D005688:Galactosamine; D001619:beta-N-Acetylhexosaminidases; D003630:Daunorubicin