[Nicotinamide has no effect on the ethanol-induced decrease in testosterone biosynthesis].
Administration of ethanol to Wistar rats in a dose of 3.5 g per 1 kg of the weight is accompanied by a decrease of testosterone concentration in the blood plasma. Nicotinamide, a NAD predecessor, exerts no effect on this index being applied in a dose of 200 mg/kg and does not modify the action of ethanol being administered in combination with the latter NAD concentration in the testicles as well as the rate of its utilization in the course of poly-ADP-ribose synthetase reaction remains unchanged. The data obtained contradict the hypothesis that ethanol effects in the testicles are determined by accessibility of oxidated NAD.
Khokha
A M
AM
Voronov
P P
PP
D000818:Animals; D000431:Ethanol / Q000037:antagonists & inhibitors*; D008297:Male; D009536:Niacinamide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000096:biosynthesis*
D009536:Niacinamide; D000431:Ethanol; D013739:Testosterone
Nikotinamid ne okazyvaet vliianiia na snizhenie biosinteza testosterona, vyzvannoe étanolom.