title: Malignant fibrous histiocytoma of soft tissue. A population-based epidemiologic and prognostic study of 137 patients.
abstract: Epidemiology and prognosis were analyzed in a consecutive, population-based series of 137 patients with malignant fibrous histiocytoma of soft tissue in the extremities and trunk wall, with a complete follow-up of minimum 3 years. All but one patient were treated by surgery in 28 cases combined with adjuvant radiotherapy or chemotherapy. The annual incidence was 0.42/10(5). The ratio men to women was 1.1. The median age was 64 years (range, 22 to 87 years). The thigh was the most common location. The median size was 6 cm. Superficial tumors constituted 43% and were smaller than deep-seated tumors. Eighty-three tumors were storiform-pleomorphic, 53 were myxoid, and one was of inflammatory type. The myxoid tumors were smaller and more often superficial. The cumulative 5-year survival rate for all patients was 0.7, but differed markedly between the histologic types; it was 1.0 in patients with myxoid tumors and 0.5 in patients with storiform-pleomorphic tumors. In the 77 patients with storiform-pleomorphic tumors without metastases at presentation, only tumor size larger than 10 cm and tumor necrosis independently impaired survival. The 23 patients who had none of these risk factors had a 5-year survival rate of 0.8.
authors.affiliation: Department of Orthopedics, University Hospital, Lund, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Rööser
authors.forename: H
authors.initials: H
authors.lastname: Willén
authors.forename: P
authors.initials: P
authors.lastname: Gustafson
authors.forename: T A
authors.initials: TA
authors.lastname: Alvegård
authors.forename: A
authors.initials: A
authors.lastname: Rydholm
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000453:epidemiology* / Q000401:mortality / Q000556:secondary / Q000628:therapy; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012983:Soft Tissue Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D015996:Survival Rate; D013548:Sweden / Q000453:epidemiology