Clinical and immunologic observations in patients with AIDS-related complex treated with IMREG-1.
An immunomodulator, IMREG-1, derived from human leukocyte dialysates exerts a variety of effects on the cell-mediated immune system, including acceleration and amplification of delayed hypersensitivity to recall antigens, modulation of gamma-interferon production in response to antigen, and enhanced expression of the p55 portion of the receptor for interleukin-2 on CD4+ cells. On the basis of initial studies of IMREG-1 in patients with AIDS-Related Complex (ARC), a multicenter randomized, double-blind, placebo controlled trial of this agent was carried out. The results indicate that patients who received IMREG-1 had a lower risk of progression to frank AIDS than those who received placebo. A decline in the rate of reduction of numbers of CD4+ cells, as well as fewer symptoms were also observed in patients who received IMREG-1 as compared with placebo.
Gottlieb
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Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana.
D000386:AIDS-Related Complex / Q000276:immunology / Q000628:therapy*; D006801:Humans; D008222:Lymphokines / Q000627:therapeutic use*
C049120:IMREG-1; D008222:Lymphokines