title: [Cutaneo-mucosal hyperpigmentation in AIDS. 4 cases].
abstract: Four cases of pigmentation of the skin and mucous membranes in homosexuals of the IVC1 group (CDC classification) are reported. The aetiological investigation, although incomplete, pointed to a medicinal origin which could not be formally confirmed. The drugs suspected were azidothymidine, pyrimethamine and ketoconazole. There was no clinical or laboratory evidence of adrenal insufficiency. The few published cases of cutaneo-mucosal pigmentation in HIV infection, often mimicking adrenal insufficiency, emphasize the need for thorough toxicological investigation; this may avoid prescribing an unnecessary and dangerous corticosteroid therapy which might be harmful in these deeply immunocompromized patients who often have multiple infections.
authors.affiliation: Hôpital de jour du CISIH, Hôpital Salvator, Marseille.
authors.forename: I
authors.initials: I
authors.lastname: Poizot-Martin
authors.forename: A
authors.initials: A
authors.lastname: Lafeuillade
authors.forename: C
authors.initials: C
authors.lastname: Dhiver
authors.forename: L
authors.initials: L
authors.lastname: Xeri
authors.forename: R
authors.initials: R
authors.lastname: Bouabdallah
authors.forename: T
authors.initials: T
authors.lastname: Gamby
authors.forename: J A
authors.initials: JA
authors.lastname: Gastaut
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000209:etiology; D010859:Pigmentation Disorders / Q000209:etiology* / Q000378:metabolism; D011739:Pyrimethamine / Q000009:adverse effects; D015215:Zidovudine / Q000009:adverse effects
chemical_list: D015215:Zidovudine; D007654:Ketoconazole; D011739:Pyrimethamine
vernacular_title: Hyperpigmentation cutanéo-muqueuse au cours du SIDA. 4 observations.