Intraperitoneal chemotherapy for malignant peritoneal mesothelioma.
4 patients with malignant peritoneal mesothelioma have been treated with intraperitoneal chemotherapy in the Netherlands Cancer Institute in the recent years. 1 patient achieved a complete remission for 36+ months and another patient had a partial remission that lasted for 10 months. Intraperitoneal chemotherapy alone or in combination with other treatment modalities may yield a response rate of 58% with 24% complete remissions in 70 patients reviewed in the literature. Although these data should be considered with caution because of the heterogenicity of the patient group treated, cisplatin-based intraperitoneal chemotherapy seems to be the best available treatment for malignant peritoneal mesothelioma at present.
Vlasveld
L T
LT
Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam.
Gallee
M P
MP
Rodenhuis
S
S
Taal
B G
BG
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy* / Q000628:therapy; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000628:therapy
D000970:Antineoplastic Agents; D002945:Cisplatin