Role of fibroblast subpopulations in periodontal physiology and pathology.
Fibroblasts are the principal cell type in the soft connective tissues of the periodontium; they perform important functions in development, physiology, and disease. A growing number of reports have indicated site-specific phenotypic variation of fibroblasts. Heterogeneity of metabolic traits has been demonstrated in cells from healthy and diseased tissues. The tissue distribution and relative proportions of fibroblast subpopulations have a significant impact on the regulation of connective tissue function in health and disease.
McCulloch
C A
CA
Faculty of Dentistry, University of Toronto, Canada.
Bordin
S
S
D002454:Cell Differentiation; D002460:Cell Line; D003094:Collagen / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D005881:Gingiva / Q000166:cytology / Q000473:pathology; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D010513:Periodontal Ligament / Q000166:cytology* / Q000473:pathology; D010519:Periodontium / Q000166:cytology*
D016326:Extracellular Matrix Proteins; D008565:Membrane Proteins; D003094:Collagen