Anticoagulant activity of galactosaminoglucuronoglycan: a pharmacological study.
An investigation was carried out to evaluate possible interference by mucopolysaccharide galactosaminoglucuronoglycans on blood clotting processes. Results obtained have demonstrated, both in vivo and in vitro, that the biopolymer has no influence on the principal blood clotting parameters taken into consideration, as regards both a single administration and treatments repeated for 30 days.
Matera
M
M
Institute of Pharmacology, Medical School, University of Catania, Italy.
Scalia
S
S
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D005170:Factor X / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000502:physiology; D005343:Fibrinolytic Agents / Q000494:pharmacology; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D008297:Male; D011817:Rabbits; D013329:Structure-Activity Relationship; D013455:Sulfur / Q000494:pharmacology; D013916:Thrombelastography
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D006025:Glycosaminoglycans; D013455:Sulfur; D005170:Factor X; D006493:Heparin