[Markers of hypercoagulability during pregnancy: thrombin-antithrombin-III complexes and D dimer].
Pregnancy can be regarded as a secondary hyper-coagulability state. The development of thrombin-anti-thrombin complexes (TATC), D dimer and anti-thrombin III (AT III) was analysed in the present work on 33 pregnant women. A significant increase of the TATC records was found between the first and third trimesters and between the second and third trimesters (p = 0.005 and p = 0.02, respectively). The AT III values were within the normal range. The values of the D dimer increased progressively during pregnancy, but only the figures achieved in the third trimester were statistically significant with respect to the control group (p = 0.14). The increase of TATC and D dimer during pregnancy are considered as hypercoagulability.
Senent
M
M
Servicios de Hematología y Ginecología, Hospital de la Santa Creu i Sant Pau, Barcelona.
Bellart
J
J
Zuazu-Jausoro
I
I
Oliver
A
A
Montserrat
I
I
Ribera
L
L
Tirado
I
I
Cabero
L
L
Fontcuberta
J
J
D000328:Adult; D000990:Antithrombin III / Q000032:analysis*; D001777:Blood Coagulation; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D013917:Thrombin / Q000032:analysis*
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D000990:Antithrombin III; D013917:Thrombin
Marcadores de hipercoagulabilidad durante el embarazo: complejos trombina-antitrombina-III y dímero D.