title: Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia.
abstract: Circulating levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol were studied in 86 patients with dementia; 45 with Alzheimer's disease and 41 with multi-infarct dementia. Compared to an elderly control group, after adjustment for age and sex, patients with Alzheimer's disease were found to have lower serum levels of DHEAS. We found a covariation between serum albumin and DHEAS levels, which may be of importance regarding peripheral hormone concentration in patients with dementia. These findings may provide evidence for a role of DHEAS in amnestic disorder in humans, either reflecting or contributing to the course of dementing diseases.
authors.affiliation: Department of Geriatric Medicine, Umeå University Hospital, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Näsman
authors.forename: T
authors.initials: T
authors.lastname: Olsson
authors.forename: T
authors.initials: T
authors.lastname: Bäckström
authors.forename: S
authors.initials: S
authors.lastname: Eriksson
authors.forename: K
authors.initials: K
authors.lastname: Grankvist
authors.forename: M
authors.initials: M
authors.lastname: Viitanen
authors.forename: G
authors.initials: G
authors.lastname: Bucht
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis*; D001812:Blood-Brain Barrier / Q000502:physiology; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D015161:Dementia, Multi-Infarct / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology; D009483:Neuropsychological Tests; D011863:Radioimmunoassay; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D012709:Serum Albumin; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone