[In vitro T cell response to merozoite antigens in the area of continuous malaria transmission].
T CELL response in vitro to merozoite extracts of P falciparum was tested in holoendémic area (Dielmo, Region of Fatick). 58 individuals (29 adults and 29 children) were sampled. Mononuclear cells from peripheral blood were cultured with the presence of merozoites antigens during 7 days. Cells were pulsed at day 6 and 3H-thymidine incorporation was measured 16h later. T Cell response high or low was evaluated by Stimulation Index (SI). This is defined as mean cpm expérimental cells/mean cpm control cells. Two groups of Responders have been identified: High Résponders: SI > or = 5 48% of subjects Low Responders: SI < 5 52% of subjects. A microparasitaemia have been found in 19 donnors without illness. 14 of these are Low Responders (89%). It was found that SI increased with the number year of exposure.
Dieye
A
A
Biochimie Pharmaceutique, Université C.A. DIOP, Dakar.
Sarthou
J L
JL
Rogier
C
C
Trape
J F
JF
Heidrich
H G
HG
D000293:Adolescent; D000328:Adult; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D002478:Cells, Cultured; D002648:Child; D006801:Humans; D010963:Plasmodium falciparum / Q000276:immunology*; D012675:Senegal; D013601:T-Lymphocytes / Q000276:immunology*
D000953:Antigens, Protozoan
Réponse cellulaire T in vitro aux antigènes de mérozoïtes en zone de transmission continue du paludisme.