[Insulin sensitivity in vivo: evaluation of non insulin dependent diabetes mellitus patients and healthy subjects by euglycemic hyperinsulinemic clamp].
Insulin resistance is commonly found in non insulin dependent diabetic patients. We used the euglycemic hyperinsulinemic clamp method to measure in vivo sensitivity to insulin in 7 non insulin dependent patients responding to oral hypoglycemic agents (Diabetics) and in 8 healthy subjects (Control). Fasting blood sugar was 136 +/- 21 vs 93 +/- 8 mg/dl respectively (p < 0.0002). Basal insulin levels were 16 +/- 9 vs 10 +/- 3 uU/ml, respectively (NS). Sensitivity to insulin was higher in diabetics (4.2 +/- 1.14 (mg/kg/min)/(uU/ml) x 100)) than in controls (7.92 +/- 1.7, p < 0.01). Efficiency in the use of insulin was lower in diabetics (3.20 +/- 0.64 vs 6.50 +/- 1.42 ml/kg/min, p < 0.002). Thus, non insulin dependent diabetics exhibit resistance to insulin. Effective treatment with oral hypoglycemic agents does not normalize insulin sensitivity.
Calvillán
M
M
Unidad de Diabetes y Nutrición, Hospital San Juan de Dios, Santiago de Chile.
Durruty
P
P
López
G
G
Rocha
G
G
D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin
Sensibilidad insulínica in vivo: evaluación en pacientes diabéticos no insulinodependientes y en sujetos sanos por clamp euglicémico hiperinsulinémico.