Molecular determinants of visual pigment function.
Mutagenesis studies and comparisons of natural variants of rhodopsin and related visual pigments have led to new insights concerning photoreceptor function. The studies identify domains important for receptor folding, the residues that set the wavelength of absorption for the ligand 11-cis retinal, and residues, that when mutated, trigger the cell death of photoreceptors.
Applebury
M L
ML
Visual Sciences Center, University of Chicago, Illinois 60637.
D000595:Amino Acid Sequence; D000818:Animals; D005136:Eye Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D012160:Retina / Q000502:physiology; D012162:Retinal Degeneration / Q000235:genetics; D012168:Retinal Pigments / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D012243:Rhodopsin / Q000235:genetics; D017299:Rod Opsins
D005136:Eye Proteins; D012168:Retinal Pigments; D017299:Rod Opsins; D012243:Rhodopsin