[Cardiac toxicity of 5-fluorouracil. Two cases].
Major ventricular repolarization disorders without evidence of myocardial infarction developed in 2 patients during the first course of a 5-fluorouracil (5-FU) treatment in doses of 1,000 mg/m2/day. Anginal pain was present in one patient but not in the other. The electrical abnormalities persisted for more than 6 weeks in one case. Explorations carried out 2 and 6 weeks later respectively under calcium inhibitors showed absence of coronary artery stenosis, negative methyl ergonovine test (even after 5-FU infusion in one patient) and normal left ventricular kinetics. The mechanism of cardiac toxicity is discussed on the basis of these data: some elements support a coronary spasm and others direct myocardial toxicity.
Samoun
M
M
Service de Médecine Interne et Néphrologie, Hôpital Ambroise-Paré, Boulogne-Billancourt.
Potocka
A C
AC
Pillière
R
R
Delorme
G
G
Prinseau
J
J
Baglin
A
A
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001984:Bronchial Neoplasms / Q000188:drug therapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002945:Cisplatin / Q000627:therapeutic use; D004562:Electrocardiography; D005472:Fluorouracil / Q000506:poisoning* / Q000627:therapeutic use; D006331:Heart Diseases / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy
D002945:Cisplatin; D005472:Fluorouracil
Cardiotoxicité du 5-fluorouracile. Deux observations.