title: [Changes in collagen biosynthesis in patients with hip joint replacement surgery and reoperation].
abstract: The authors investigated the intensity of collagen synthesis in patients subjected to operation or re-operation of a total endoprosthesis of the hip joint. The patients suffered from osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. The authors assessed the activity of collagen glucosyl transferase (S-GGT) and the concentration of the N-terminal propeptide procollagen type III by two methods (S-Pro III-N-P and S-Fab) in serum before and after operation. A significant rise of S-GGT and S-Fab, as compared with controls, occurred only after operation while S-Pro III-N-P was elevated already before operation. S-GGT did not differ before and after operation, while N-propeptide concentration rose when either method was used.
authors.affiliation: Výzkumný ústav chorob revmatických, Praha.
authors.forename: R
authors.initials: R
authors.lastname: Becvár
authors.forename: R
authors.initials: R
authors.lastname: Myllylä
authors.forename: M
authors.initials: M
authors.lastname: Krbec
authors.forename: O
authors.initials: O
authors.lastname: Cech
authors.forename: M
authors.initials: M
authors.lastname: Adam
mesh_terms: D000328:Adult; D000368:Aged; D001799:Blood Sedimentation; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D005964:Glucosyltransferases / Q000378:metabolism; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism; D011347:Procollagen / Q000378:metabolism; D012086:Reoperation
chemical_list: D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D003094:Collagen; D005964:Glucosyltransferases; C023247:UDP glucose-collagen glucosyltransferase
vernacular_title: Zmĕny biosyntézy kolagenu u nemocných s operací a reoperací náhrady kycelního kloubu.