Rat cortical sigma receptors differentially regulated by pentazocine and haloperidol.
Repeated administrations of 7.5 mg/kg of pentazocine (for 14 days) resulted in a significant decrease in the affinity of 3H-haloperidol binding to rat cortical sigma receptors without any changes in the maximal number of binding sites (Bmax). On the other hand, similar treatment with haloperidol (2 or 4 mg/kg) induced a dose dependent decrease in the Bmax values without affecting the affinity of the 3H-haloperidol binding. These findings indicate that rat cortical sigma receptors are differentially regulated by pentazocine and haloperidol.
Kizu
A
A
Department of Psychiatry and Neurology, Asahikawa Medical College, Japan.
Yoshida
Y
Y
Miyagishi
T
T
D000818:Animals; D015536:Down-Regulation / Q000187:drug effects; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009292:Narcotic Antagonists; D010423:Pentazocine / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects*; D017480:Receptors, sigma
D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017480:Receptors, sigma; D006220:Haloperidol; D010423:Pentazocine