title: Comparison of treatments in a combination therapy trial.
abstract: Although the min test proposed by Laska and Meisner (1) for testing superiority of a combination to each of its components is the uniformly most powerful monotone test, it is conservative in the neighborhood of origin. Considering a restricted null hypothesis, we analyze a general linear model. The p value associated with the proposed test and a confidence interval for the shortest distance between the combination therapy and component therapies are computed. Analysis of a design with two or more combinations is proposed. A numerical example is given and a problem of optimal allocation of the sample sizes and other relevant design issues are discussed.
authors.affiliation: Berlex Laboratories, Inc. Wayne, New Jersey 07470.
authors.forename: H I
authors.initials: HI
authors.lastname: Patel
mesh_terms: D016001:Confidence Intervals; D003971:Diastole / Q000187:drug effects; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D016018:Least-Squares Analysis; D008954:Models, Biological; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000706:statistics & numerical data*; D012107:Research Design / Q000706:statistics & numerical data*; D012984:Software