title: [DNA-breaking action of ascorbic acid in the presence of Cu(II)/demethylcantharic acid complex].
abstract: Effects of various factors on the DNA-breaking action of ascorbic acid in the presence of Cu(II)/demethylcantharic acid complex were studied in phosphate buffer (pH 7.40), at 37.0 +/- 0.1 degrees C. It was shown that .OH produced from Fenton reaction of H2O2 which can be formed from the oxidation of ascorbic acid was responsible for the DNA-breaking action of ascorbic acid and the simple Fenton reaction cannot explain all the results.
authors.affiliation: Physical Chemistry Department, School of Pharmaceutical Sciences, Beijing Medical University.
authors.forename: P H
authors.initials: PH
authors.lastname: Li
authors.forename: Y H
authors.initials: YH
authors.lastname: Pang
mesh_terms: D001205:Ascorbic Acid / Q000494:pharmacology*; D002614:Chelating Agents / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D004249:DNA Damage; D011479:Protamines / Q000235:genetics
chemical_list: D002614:Chelating Agents; D011479:Protamines; D003300:Copper; D001205:Ascorbic Acid