[Synthesis of a potential metabolite of the carcinostatic bendamustin (Cytostasen)].
The synthesis of the methylester of (5-[Bis(2-chlorethyl)amino]-1-methyl-benzimidazolyl-(2))ethanolic acid (4) has been described. The assumption that the butanoic acid group of the anticancer drug bendamustine (Cytostasan) will be biotransformed in patients to the ethanoic acid group as found for chlorambucil has been disproved by means of a comparison of the methylated metabolites and 4 by MS and HPLC.
Werner
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Zentralinstitut für Mikrobiologie und experimentelle Therapie, Humboldt-Universität zu Berlin.
Letsch
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Ihn
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Sohr
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Preiss
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D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D000069461:Bendamustine Hydrochloride; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D013058:Mass Spectrometry; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; C069891:5-(bis(2-chloroethyl)amino)-1-methylbenzimidazolyl-2-acetic acid methyl ester; D000069461:Bendamustine Hydrochloride
Synthese eines potentiellen Metaboliten des Kanzerostatikums Bendamustin (Cytostasen).