title: A case of trisomy 21 with holoprosencephaly: the fifth case.
abstract: A case of trisomy 21 with holoprosencephaly, the fifth case in the literature, is described. The patient also had extracephalic malformations frequently associated with Down syndrome. The possibility of a causal relationship between trisomy 21 and holoprosencephaly is discussed.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Arinami
authors.forename: M
authors.initials: M
authors.lastname: Koresawa
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: H
authors.initials: H
authors.lastname: Hamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Iwasaki
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D016142:Holoprosencephaly / Q000235:genetics*; D006801:Humans; D007564:Japan; D011247:Pregnancy