[Determination of anticoagulant activity of heparin].
Heparin samples from four manufacturers and the First Argentinian Standard Heparin obtained from porcine mucosa were assayed by the Reinert and Winterstein method, modified as suggested by USP and Brazilian Pharmacopeias. Other methods described in the literature and their importance for the evaluation of anticoagulant activity of unfractionated heparins with low molecular weight are discussed.
Dalmora
S L
SL
Departamento de Farmćia Industrial, Universidade Federal de Santa Maria-RS.
Assaf
G S
GS
Dalmora
M E
ME
Vaucher
L C
LC
Vaccari
S F
SF
D000818:Animals; D001665:Binding Sites; D001681:Biological Assay; D001777:Blood Coagulation / Q000187:drug effects*; D006493:Heparin / Q000737:chemistry / Q000494:pharmacology*; D008970:Molecular Weight; D012015:Reference Standards; D012756:Sheep; D013329:Structure-Activity Relationship; D013552:Swine
D006493:Heparin
Determinação da atividade anticoagulante da heparina.