Detection of Fc gamma-receptor blocking antibodies in the serum following vaccination.
In the current series of experiments the Fc gamma-receptor blocking serum activity (EAI) was studied before and after vaccination with tetanus toxoid and rDNA HBsAg vaccines in two groups of 6 healthy persons. The analysis of the individual serum samples (on three different allogeneic and on autologous B lymphocytes) suggests that two types of EAI antibodies were produced: allo- and autoantibodies. In all cases an increase of EAI activity was noticed after immunization (in the cases of tetanus toxoid vaccination from 17.7 +/- 9.7 to 39.3 +/- 16.0 and in the cases of virus vaccination from 67.4 +/- 16.5 to 80.2 +/- 4.5).
Petri
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Blood Transfusion Centre, A. Szent-Györgyi Medical University, Szeged, Hungary.
Szekeres
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D000943:Antigens, Differentiation / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007518:Isoantibodies / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology*; D017452:Receptors, IgG; D012397:Rosette Formation; D013997:Time Factors; D014611:Vaccination
D000943:Antigens, Differentiation; D001323:Autoantibodies; D007074:Immunoglobulin G; D007518:Isoantibodies; D011961:Receptors, Fc; D017452:Receptors, IgG