An experimental and mathematical analysis of lymphopoiesis dynamics under continuous irradiation.
A mathematical model describing the dynamics of lymphopoiesis in mammals continuously exposed to ionizing radiation has been developed. It is based on the theory of chalone regulation of hematopoiesis. The model comprises a system of nine differential equations. Results from the model were compared with our experimental data for bone marrow and blood lymphocytes of rats continuously exposed to gamma radiation in a wide range of dose rates. The model reproduces the lymphopoiesis dynamics that we observed in our experiment, in particular, the radiation hormesis at low dose rates, the reduction of lymphopoiesis at intermediate dose rates, and extinction of lymphopoiesis at high dose rates of continuous radiation. The possible explanation of the hormesis is suggested by the framework of the model. The model can be used for predicting the lymphopoiesis dynamics in mammals under continuous irradiation.
Zukhbaya
T M
TM
Institute of Medicobiological Problems of USSR, Ministry of Health, Moscow.
Smirnova
O A
OA
D000818:Animals; D006131:Growth Inhibitors / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology* / Q000528:radiation effects; D008214:Lymphocytes; D008433:Mathematics; D008954:Models, Biological; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D051381:Rats
D006131:Growth Inhibitors