Inhibition of growth of a tapeworm Hymenolepis diminuta in its normal host (rat).
The biomass of 8-day-old worms of Hymenolepis diminuta in secondary infections, administered to rats 3-10 days after chemotherapeutically expelling a primary infection, was 70-90% less, and the worms were more posteriorly distributed, than in naive controls. The strong depressive effect on growth waned rapidly over 2-5 weeks, but even in rats not challenged until 17 months later, worm growth was weakly depressed by 30%. The extent to which growth was depressed in a secondary infection was independent of the number of worms in the challenge but increased with number of worms in the immunizing infection up to four to eight worms. Further increase up to 64 worms had little effect. This suggests, as it is known that the biomass of worms in a rat reaches a maximum with infections of between five and 10 worms, that the change in the intestine is proportional to biomass, not number, of worms. It is argued that partially suppressed immuno-inflammatory changes in the intestine, which will affect secondary worms so strongly, will also have depressed growth and fecundity effects on the primary worms, that a dynamic equilibrium is reached between the strength of the intestinal response and the biomass of the tapeworm, and that it is reaching this equilibrium, not a 'crowding effect', which limits H. diminuta to a level compatible with the survival of the rat.
Hopkins
C A
CA
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Scotland, U.K.
Andreassen
J
J
D000818:Animals; D005260:Female; D006925:Hymenolepiasis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D006926:Hymenolepis / Q000254:growth & development / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains / Q000469:parasitology*; D012376:Rodent Diseases / Q000276:immunology* / Q000469:parasitology; D013047:Specific Pathogen-Free Organisms