Systemic contact dermatitis from pseudoephedrine.
A patient with rhinitis developed systemic contact dermatitis when starting oral treatment with Rhinalair, containing pseudoephedrine hydrochloride. A few months later, another oral treatment Rinutan, containing norephedrine hydrochloride, provoked a more severe generalized eczema. Patch test reactions were strongly positive to ephedrine and pseudoephedrine, slightly positive to phenylephrine and negative to epinephrine. Norephedrine was not tested.
Tomb
R R
RR
Clinique Dermatologique, Hôpital Civil, Strasbourg, France.
Lepoittevin
J P
JP
Espinassouze
F
F
Heid
E
E
Foussereau
J
J
D000368:Aged; D003877:Dermatitis, Contact / Q000209:etiology*; D003875:Drug Eruptions / Q000209:etiology*; D004809:Ephedrine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010665:Phenylpropanolamine / Q000009:adverse effects; D012008:Recurrence; D012220:Rhinitis / Q000188:drug therapy
D010665:Phenylpropanolamine; D004809:Ephedrine