Role of dopamine1-receptors in mediating renal responses to furosemide in the rat.
1. Dopamine (DA) infusion enhanced the diuresis, natriuresis and kaliuresis evoked by furosemide, but this increase was significantly lower in the presence of SCH 23390, a selective DA1-dopaminergic antagonist. 2. Water, Na+ and K+ excretion induced by furosemide were reduced by haloperidol, and SCH 23390, whereas they were not affected by +/- sulpiride, a preferentially DA2-dopaminergic antagonist. 3. The treatments used did not modify the mean blood pressure during the experiments. 4. Our data show that renal responses to furosemide are attenuated by the DA1-dopaminergic antagonist. It is possible that endogenous DA, stimulating DA1 receptors in the rat kidney may be an important factor involved in the Na+, K+ and water excretion evoked by furosemide.
Nowicki
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Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, UBA, Buenos Aires, Argentina.
Enero
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D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*; D017447:Receptors, Dopamine D1; D012964:Sodium / Q000652:urine; D013469:Sulpiride / Q000494:pharmacology
D001552:Benzazepines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D005665:Furosemide; D013469:Sulpiride; D012964:Sodium; D006220:Haloperidol; D011188:Potassium; D004298:Dopamine