title: Selective homing of phenotypically lytic cells within nasopharyngeal carcinoma biopsies: numerous CD8- and CD16-positive cells in the tumor.
abstract: We present a comparative analysis of cell-mediated immunity between circulating lymphocytes and tumor-infiltrating lymphocytes (TIL) from patients with nasopharyngeal carcinoma (NPC). Phenotypic analysis using a panel of monoclonal antibodies (MAbs) to define lymphocytic subsets has revealed a selective homing of phenotypically lytic cells such as CD8- and CD16-positive cells, but a low percentage of macrophages when compared to PBL of NPC patients. Also, PBL and TIL contain an equivalent percentage of activated T-lymphocytes expressing HLA-DR molecules and IL-2 receptors. Functionally, TIL exhibit an abolished NK-cell activity and concomitant decrease of proliferative response to phytohemagglutinin (PHA) and concanavalin A (ConA) stimulation when compared with PBL.
authors.affiliation: Unité de Recherche d'Immunologie Cellulaire, Hôpital Militaire Principal d'Instruction de Tunis, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Lakhdar
authors.forename: M H
authors.initials: MH
authors.lastname: Ben Aribia
authors.forename: M
authors.initials: M
authors.lastname: Maalej
authors.forename: A
authors.initials: A
authors.lastname: Ladgham
mesh_terms: D015703:Antigens, CD / Q000032:analysis*; D000943:Antigens, Differentiation / Q000032:analysis*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001706:Biopsy; D016827:CD8 Antigens; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000473:pathology; D037102:Lectins; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology; D009303:Nasopharyngeal Neoplasms / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D011961:Receptors, Fc / Q000032:analysis*; D017452:Receptors, IgG
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D037102:Lectins; D011961:Receptors, Fc; D017452:Receptors, IgG