Unusual serpentine hyperpigmentation associated with 5-fluorouracil. Case report and review of cutaneous manifestations associated with systemic 5-fluorouracil.
A variety of cutaneous reactions have been reported with the use of systemic 5-fluorouracil. Our patient had serpentine hyperpigmented streaks appearing 5 days after bolus infusion of 5-fluorouracil. The patient also had other skin eruptions, that is, inflammation of actinic keratoses and folliculitis limited to the forehead; these reactions have been reported previously with 5-fluorouracil medication. We report this case and review the literature on skin manifestations associated with 5-fluorouracil therapy.
Vukelja
S J
SJ
Hematology/Oncology Service, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200.
Bonner
M W
MW
McCollough
M
M
Cobb
P W
PW
Gaule
D A
DA
Fanucchi
P J
PJ
Keeling
J H
JH
D000230:Adenocarcinoma / Q000188:drug therapy; D000368:Aged; D003875:Drug Eruptions / Q000209:etiology*; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced; D010859:Pigmentation Disorders / Q000139:chemically induced*; D012004:Rectal Neoplasms / Q000188:drug therapy
D005472:Fluorouracil