Sjögren's syndrome complicated by cryoglobulinaemia and acute renal failure.
A patient is described with Sjögren's syndrome and an IgM-kappa gammopathy. With time cryoglobulins, the cause of acute renal failure, could be detected. The kidney biopsy showed a proliferative glomerulonephritis as is frequently seen with mixed cryoglobulinaemia. Plasmapheresis and immunosuppression resulted in long-term improvement of kidney function. The differential diagnosis of acute renal failure of glomerular origin in a patient with Sjögren's syndrome is discussed. This case report illustrates once more the consequences of monoclonal B-cell lymphocyte activation in Sjögren's syndrome.
van Eer
M Y
MY
Division of General Internal Medicine, St. Radboud University Hospital, Nijmegen, The Netherlands.
Netten
P M
PM
Schrijver
G
G
Assmann
K J
KJ
Wollersheim
H
H
D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000368:Aged; D001706:Biopsy; D003449:Cryoglobulinemia / Q000150:complications*; D005260:Female; D006801:Humans; D012859:Sjogren's Syndrome / Q000150:complications*