title: Hyperventilation as a model for acute ischaemic hypoxia of the brain: effects on cortical auditory evoked potentials.
abstract: Controlled hyperventilation (HV) may be used as an experimental procedure to produce transient ischaemic hypoxia of the brain. The effect of HV on the cortical auditory evoked potential (AEP) components N1 and P2 was studied in ten healthy adult subjects. AEP were recorded before HV, during 3 min of controlled HV, and 1 min and 5 min after the end of HV. The P2 amplitude was significantly reduced by HV and regained its initial value 1 min after the end of HV. The P2 amplitude decrease probably reflects an impairment of synaptic function produced by cerebral hypoxia. Thus, the investigation of cortical AEP components may provide a useful parameter in the study of anti-ischaemic or anti-hypoxic therapies.
authors.affiliation: Neurologische Universitätsklinik Göttingen, Federal Republic of Germany.
authors.forename: G
authors.initials: G
authors.lastname: Adler
mesh_terms: D000293:Adolescent; D000328:Adult; D002545:Brain Ischemia / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D002540:Cerebral Cortex / Q000098:blood supply / Q000503:physiopathology*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology*; D002534:Hypoxia, Brain / Q000503:physiopathology*; D008297:Male; D008959:Models, Neurological
chemical_list: D002245:Carbon Dioxide