Aqueous carbonic acid: a readily removable electrolyte for the recovery of [18F]fluoride from anion exchange resins.
[18F]Fluoride was recovered from [18O]target water in high yield by trapping it on a microcolumn of an anion exchange resin (20 mg Dowex 1 x 8, 400 mesh) and subsequent elution of the column (in the reverse direction) by aqueous carbonic acid at 52 atm. The carbonic acid was removed from the [18F]fluoride solution by brief heating at 85 C, 1 atm. Thus no extraneous electrolyte was introduced by the extraction process. The resulting bicarbonate form of the resin was immediately capable of trapping further [18F]fluoride, permitting a repetitive remote system for recovery of [18O]water. Chloride was substantially retained on the column permitting separation of [18F]fluoride from the former.
Jewett
D M
DM
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0552.
D000837:Anion Exchange Resins; D002255:Carbonic Acid; D004573:Electrolytes; D005462:Fluorine Radioisotopes / Q000302:isolation & purification*; D010103:Oxygen Isotopes; D014867:Water / Q000032:analysis
D000837:Anion Exchange Resins; D004573:Electrolytes; D005462:Fluorine Radioisotopes; D010103:Oxygen Isotopes; D014867:Water; D002255:Carbonic Acid