[Gentamicin may have an influence on the effectiveness of peritoneal dialysis].
An effect of gentamicin on urea and uric acid transfer through peritoneum was studied in rabbits in vitro. It was found that gentamicin decreases urea transfer by approximately 30%. Its effect on uric acid transfer was transient so as mean values of this parameter did not differ statistically before and after antibiotic administration. It may be assumed that gentamicin decreases permeability of peritoneum for certain low molecules of endogenic origin. Such an effect may prove unfavourable when peritoneal dialysis efficiency is concerned.
Czyzewska
K
K
Katedry i Zakładu Patofizjologii AM im. K. Marcinkowskiego w Poznaniu.
Knapowski
J
J
D000818:Animals; D005839:Gentamicins / Q000494:pharmacology*; D066298:In Vitro Techniques; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000187:drug effects*; D010539:Permeability / Q000187:drug effects; D011817:Rabbits; D014508:Urea / Q000493:pharmacokinetics*; D014527:Uric Acid / Q000493:pharmacokinetics*
D005839:Gentamicins; D014527:Uric Acid; D014508:Urea
Gentamycyna moze mieć wpływ na efektywność dializy otrzewnowej.