Genetics of alcoholism: effects of migration on concordance rates among male twins.
We have extended linkage of the population-based Finnish Twin Cohort to alcohol-related hospital discharge data through 1985. The sample included 10,680 individual male twins > or = age 30 at time of linkage; 269 of these twins (2.5%) had received an alcohol-related hospital diagnosis. Twin analyses confirm significant genetic variance in alcohol-related disorders, but suggest that concordance for these disorders is greater for twins living within limited geographic areas, perhaps due to restricted social mobility among those who abuse alcohol.
Romanov
K
K
Department of Public Health, University of Helsinki, Finland.
Kaprio
J
J
Rose
R J
RJ
Koskenvuo
M
M
D000328:Adult; D000437:Alcoholism / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D015331:Cohort Studies; D003710:Demography; D004200:Diseases in Twins / Q000453:epidemiology / Q000235:genetics*; D004777:Environment; D005387:Finland / Q000453:epidemiology; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic