Toxicokinetic aspects of chronic cyanide exposure in the rat.
Rats received 40, 80 and 160 mg KCN/kg body wt./24 h in the drinking water for 13 weeks. Fairly constant dose-related cyanide and thiocyanate levels were measured in blood, plasma and urine during the exposure. Blood cyanide concentrations were in the range of 16.0-25.5 nmol CN-/ml blood, thiocyanate concentrations in the range of 341-877 nmol SCN-/ml plasma following continuous administration of the maximum tolerated dose-level of 160 mg/kg body wt/24 h. The results suggest that continuous 13-week maximum tolerated cyanide exposure does not lead to saturation of cyanide detoxification pathways.
Leuschner
J
J
Laboratory of Pharmacology and Toxicology, Hamburg, F.R.G.
Winkler
A
A
Leuschner
F
F
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D007928:Lethal Dose 50; D008297:Male; D011190:Potassium Cyanide / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013861:Thiocyanates / Q000097:blood / Q000652:urine
D013861:Thiocyanates; D011190:Potassium Cyanide