title: [131I]metaiodobenzylguanidine therapy in paraganglioma.
abstract: Our experience with [131I]metaiodobenzylguanidine (131I-MIBG) therapy in a 10 year old boy is reported. At disease onset, in May 1988, this boy presented a large mass in the upper left abdominal quadrant, which was resected with a histopathological diagnosis of extra-adrenal malignant pheochromocytoma (paraganglioma). He subsequently underwent two further surgical resections and chemotherapy. When 131I-MIBG therapy was started, in June 1990, skeletal and abdominal metastases were present. These localizations were revealed by 131I-MIBG scans and confirmed by x-ray examination. At present 6 courses of therapy have been performed with a cumulative activity of 29.6 GBq. Side-effects have been limited to vomiting and mild thrombocytopenia, lasting 2 weeks during the second course of therapy. After 15 months of therapy, a progressive reduction of MIBG uptake, coupled with a stabilization of the lythic lesions, has been observed.
authors.affiliation: Division of Nuclear Medicine, National Cancer Institute, Milan, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Castellani
authors.forename: L
authors.initials: L
authors.lastname: Rottoli
authors.forename: L
authors.initials: L
authors.lastname: Maffioli
authors.forename: M
authors.initials: M
authors.lastname: Massimino
authors.forename: F
authors.initials: F
authors.lastname: Crippa
authors.forename: G L
authors.initials: GL
authors.lastname: Buraggi
mesh_terms: D019797:3-Iodobenzylguanidine; D000008:Abdominal Neoplasms / Q000556:secondary* / Q000628:therapy; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary* / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000627:therapeutic use*; D008297:Male; D010235:Paraganglioma / Q000556:secondary* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine