title: Effects of purified Pasteurella multocida dermonecrotoxin on the nasal ventral turbinates of fattening pigs: histological observations.
abstract: Fattening specific pathogen-free derived pigs were injected intramuscularly with dermonecrotoxin of Pasteurella multocida, capsular type D. Ten days later, the nasal ventral turbinates and liver were examined histologically. A moderate turbinate atrophy was observed due to an increased number of osteoclasts and the absence of intramembranous bone apposition. Liver lesions were limited to some hepatocyte necrosis, sinusoid neutrophil infiltration and Kupffer cell hypertrophy. This study demonstrated that adult pigs are sensitive to P. multocida dermonecrotoxin.
authors.affiliation: Groupe de recherche sur les maladies infectieuses du porc, Faculté de Médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec.
authors.forename: B
authors.initials: B
authors.lastname: Martineau-Doizé
authors.forename: J
authors.initials: J
authors.lastname: Ménard
authors.forename: C
authors.initials: C
authors.lastname: Girard
authors.forename: J C
authors.initials: JC
authors.lastname: Frantz
authors.forename: G P
authors.initials: GP
authors.lastname: Martineau
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000009:adverse effects*; D003885:Dermotoxins / Q000009:adverse effects*; D016979:Pasteurella multocida; D012222:Rhinitis, Atrophic / Q000139:chemically induced / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced*; D014420:Turbinates / Q000187:drug effects* / Q000473:pathology
chemical_list: D001427:Bacterial Toxins; D003885:Dermotoxins; C052804:dermonecrotic toxin, Pasteurella multocida