Elevated lipoprotein(a) levels in renal transplantation and hemodialysis patients.
Hyperlipidemia poses a risk for cardiovascular disease in both hemodialysis and renal transplantation patients. Although lipid profiles differ between the 2 populations, we evaluated the possibility that both groups have similar abnormalities of lipoprotein(a) [Lp(a)]. Mean serum Lp(a) and standard error of the mean (SEM) in hemodialysis and transplant recipients was 16.6 +/- 4.7 and 18.3 +/- 3.6 mg/dl, respectively, compared with 10.7 +/- 4.1 mg/dl in healthy controls, p less than 0.05. That serum Lp(a) levels are significantly elevated in dialysis and renal transplantation patients suggests at least 1 common pathogenic mechanism for the high incidence of atherosclerosis in both groups.
Heimann
P
P
Department of Pathology, University of Chicago, Pritzker School of Medicine, Ill.
Josephson
M A
MA
Fellner
S K
SK
Thistlethwaite
J R
JR
Stuart
F P
FP
Dasgupta
A
A
D000328:Adult; D001161:Arteriosclerosis / Q000453:epidemiology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D016030:Kidney Transplantation; D017270:Lipoprotein(a); D008074:Lipoproteins / Q000097:blood*; D008297:Male; D010958:Plasminogen / Q000037:antagonists & inhibitors; D006435:Renal Dialysis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D017270:Lipoprotein(a); D008074:Lipoproteins; D014280:Triglycerides; D010958:Plasminogen; D002784:Cholesterol