Extra Y chromosome in chronic lymphoproliferative disorders.
Using separated lymphocytes from 95 male patients with B-cell lymphoproliferative disorders, we have established both Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and short-term cultures with polyclonal B-cell mitogens. Cytogenetic studies of these patients revealed an extra Y chromosome in 4 of 71 male cell lines examined. An extra Y chromosome appeared to be the sole karyotype change (47,XY, + Y) in 2 of these 4 patients. The extra Y chromosome was accompanied by extra copies of chromosomes 12 and 21 (48,XY, + Y, + 12 and 48,XY, + Y, + 21) in the other 2 patients, respectively. The possible oncological role of the extra Y chromosome in the initiation of leukemia is discussed.
Xiao
H
H
Cytogenetics Laboratory, Roswell Park Memorial Institute, Buffalo, New York 14263.
Dadey
B
B
Block
A W
AW
Han
T
T
Sandberg
A A
AA
D000368:Aged; D000369:Aged, 80 and over; D002472:Cell Transformation, Viral; D002869:Chromosome Aberrations; D002908:Chronic Disease; D004854:Herpesvirus 4, Human / Q000472:pathogenicity; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D007943:Leukemia, Hairy Cell / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics; D008297:Male; D008875:Middle Aged; D014998:Y Chromosome