T-cell receptor isoforms and signal transduction.
Recent cDNA and genomic cloning have identified CD3 eta as an alternatively spliced product of the same gene locus that encodes CD3 zeta. Three distinct T-cell receptor isoforms have now been identified. A current view of the signal transduction function of these isoforms in thymocytes and T cells is discussed.
Koyasu
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Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
D'Adamio
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Clayton
L K
LK
Reinherz
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EL
D000945:Antigens, Differentiation, T-Lymphocyte / Q000096:biosynthesis / Q000235:genetics; D017252:CD3 Complex; D002118:Calcium / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D014176:Protein Biosynthesis; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D014158:Transcription, Genetic
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D010716:Phosphatidylinositols; D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases; D002118:Calcium