The utility of 99mTc-mercaptoacetyltriglycine in captopril renography.
99mTc-Mercaptoacetyltriglycine (MAG3) is a new 99mTc renal radiopharmaceutical with properties similar to orthoiodohippurate (OIH). 99mTc-MAG3 is highly protein bound and is efficiently extracted by the proximal tubules. While the clearance is only 50 to 65% that of OIH, the plasma concentration is higher and the rates at which the two tracers appear in the urine are almost identical. Studies comparing 99mTc-MAG3 and OIH in animals with renovascular hypertension (RVH) show comparable results. Preliminary studies comparing 99mTc-MAG3 renography with angiography in hypertensive patients show promising results and suggest 99mTc-MAG3 will probably have a sensitivity and specificity for detecting RVH similar to OIH. The optimal criteria for defining an abnormal study still need to be determined and then applied in a prospective study.
Taylor
A
A
Department of Radiology, Emory University Medical Center, Atlanta, Georgia 30322.
Martin
L G
LG
D000818:Animals; D002216:Captopril; D002986:Clinical Trials as Topic; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging*; D009842:Oligopeptides; D015609:Organotechnetium Compounds; D011866:Radioisotope Renography / Q000379:methods*; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging*; D017263:Technetium Tc 99m Mertiatide
D009842:Oligopeptides; D015609:Organotechnetium Compounds; D017263:Technetium Tc 99m Mertiatide; D002216:Captopril