[Effect of verapamil on cyclosporine-induced vasoconstriction in human or murine isolated glomerules].
Cyclosporin is a very potent immunosuppressant, but it often produces renal disturbances which limit its clinical use. Using an image analyzer which determines the areas of isolated glomerules, we were able to demonstrate that cyclosporin in various concentrations exerts a direct vasoconstrictive effect on human and murine glomerules. We also showed that verapamil has an almost total inhibitory effect on cyclosporin-induced vasoconstriction. These findings seem to be of interest in clinical practice to reduce the nephrotoxicity of cyclosporin.
L'Azou
B
B
Groupe d'Etude de Physiologie et Physiopathologie Rénales, Faculté de Pharmacie, Bordeaux.
Lakhdar
B
B
Potaux
L
L
Aparicio
M
M
Cambar
J
J
D000818:Animals; D016572:Cyclosporine / Q000009:adverse effects / Q000494:pharmacology*; D003864:Depression, Chemical; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D014661:Vasoconstriction / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D016572:Cyclosporine; D014700:Verapamil
Influence du vérapamil sur la vasoconstriction induite par la ciclosporine sur glomérules isolés humains et murins.