Influence of L-tetramisole on the interferon production by mouse peritoneal and L929 cells.
The effect of L-tetramisole (Levamisole, Decaris) on the physiological interferon beta (INF beta) production by freshly isolated peritoneal cells of BALB/c, NZB and C3H mouse strains was studied. We have shown that these strains differ in their ability to produce physiological IFN. Peritoneal cells of individual BALB/c and NZB mice differed significantly in ability to produce the physiological IFN, but most of these animals are good producers, while the cells isolated from C3H mice are not. High concentrations of L-tetramisole (250 and 500 micrograms/ml) suppressed IFN synthesis in the cells from BALB/c and NZB mice. Lower concentration of L-tetramisole (125 micrograms/ml) inhibited the IFN production only partially and this effect was observed when the IFN production was high. When the IFN production was very low, L-tetramisole slightly increased the synthesis. L-tetramisole affected the production of the physiological IFN, but not the production of IFN induced by Newcastle disease virus (NDV) in the peritoneal cells of mice or in L929 cells.
Błach-Olszewska
Z
Z
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Zaczyńska
E
E
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology; D002460:Cell Line; D005260:Female; D066298:In Vitro Techniques; D016899:Interferon-beta / Q000096:biosynthesis*; D007978:Levamisole / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity
D007978:Levamisole; D016899:Interferon-beta