Atrial dynamics and release of atrial natriuretic factor in vivo.
In anaesthetized rabbits blood volume was altered by infusion and withdrawal of donor blood over the range of +60 to -40% of the blood volume. Right and left atrial pressures were measured and it was shown that sonomicrometry allowed adequate measurement of phasic changes in atrial dimensions. Plasma immunoreactive atrial natriuretic peptide concentration changed in a nonlinear fashion with changes in blood volume, and was linearly related to both peak systolic and peak diastolic right and left atrial wall stress. It was not possible to make the distinction between distension (diastolic stress) or tension (systolic stress) as the major determinant of ANF release in response to changes in blood volume.
Ledsome
J R
JR
Department of Physiology, University of British Columbia, Vancouver, Canada.
King
K A
KA
D000758:Anesthesia; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001810:Blood Volume / Q000502:physiology; D003971:Diastole / Q000502:physiology; D004562:Electrocardiography; D006325:Heart Atria / Q000033:anatomy & histology / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D013599:Systole / Q000502:physiology
D009320:Atrial Natriuretic Factor