[Synthesis of porphyrin derivatives].
This paper presents the preparation of eleven 2, 4 or 6, 7-substituted porphyrine derivatives II-XII from I or diethyl ether of IV. The effects of these compounds, with irradiation, on DNA synthesis in L1210 cells were studied. The results showed that (1) all of these compounds were effective while (2) Va or Vb, VI and VII were more effective.
Lu
Y H
YH
Department of Chemistry, Chinese Academy of Medical Sciences, Beijing.
Liu
F C
FC
D000818:Animals; D004273:DNA, Neoplasm / Q000096:biosynthesis; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000138:chemical synthesis; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D010778:Photochemotherapy; D011166:Porphyrins / Q000138:chemical synthesis* / Q000494:pharmacology; D011524:Protoporphyrins; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis
D004273:DNA, Neoplasm; D006415:Hematoporphyrins; D011166:Porphyrins; D011524:Protoporphyrins; D011838:Radiation-Sensitizing Agents; D017324:Hematoporphyrin Derivative