Anti-inflammatory and immunomodulating effects of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone. 3rd communication: effect on suppressor cells and cytokines production in normal and adjuvant arthritic rats.
The novel agent gamma-(2-aminoethylamino-2-butyrothienone (gamma-ABT) has been found to suppress adjuvant induced disease (AID). To explore the mechanism of action of gamma-ABT in AID, the effects of gamma-ABT on suppressor cells, found in AID, and on interleukin production were evaluated. gamma-ABT did not affect the concavalin A (Con A) responses of AID splenocytes when the suppressor plastic-glass and glass-only-adherent cells were removed. gamma-ABT affected the Con A responses of glass-adherent cells indicating that this agent is selectively affecting the glass-adherent suppressor cells. Interleukins 1 and 2 production is augmented by gamma-ABT in normal and AID rats. Since IL-1 abrogated the suppressive effect of glass-adherent suppressor cells, it is suggested that the inhibition of IL-1 mediated events of suppressor cells may be one of the mechanisms of action of gamma ABT in AID. The relevance of the present results to a latent virus etiology of AID is discussed.
Karagouni
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EE
Department of Genetics, Development and Molecular Biology, School of Biology, Faculty of Sciences, Aristotelian University, Thessaloniki, Greece.
Kourounakis
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D000276:Adjuvants, Immunologic; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001169:Arthritis, Experimental / Q000378:metabolism*; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008297:Male; D008934:Mitogens; D051381:Rats; D011916:Rats, Inbred F344; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*; D013876:Thiophenes / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D007375:Interleukin-1; D007376:Interleukin-2; D008934:Mitogens; D013876:Thiophenes; C070063:gamma-(2-aminoethylamino)-2-butryothienone