Nanoparticles as drug carriers for vinblastine. Acute toxicity of vinblastine in a free form and associated to polybutylcyanoacrylate nanoparticles.
The possibility of reducing toxicity of Vinblastine by fixing it in polybutyl-2-cyanoacrylate nanoparticles was studied. A significant reduction of mortality of mice was recorded after a single intraperitoneal (i. p.) injection of nanoparticle-associated Vinblastine. A wide range of doses of Vinblastine (1.04-6.25 mg/kg) were used. There was a considerable decrease of leucopenia caused by Vinblastine-loaded polybutyl-2-cyanoacrylate nanoparticles as compared to that induced by free Vinblastine.
Simeonova
M
M
Scientific Research Centre for Speciality Polymers, Sofia.
Ilarionova
M
M
Ivanova
T
T
Konstantinov
C
C
Todorov
D
D
D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D004337:Drug Carriers; D004659:Enbucrilate; D007274:Injections, Intraperitoneal; D051379:Mice; D008815:Mice, Inbred Strains; D008863:Microspheres; D013056:Spectrophotometry, Ultraviolet; D014747:Vinblastine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity
D004337:Drug Carriers; D014747:Vinblastine; D004659:Enbucrilate