Interleukin 1 signal transduction.
Interleukin 1 signals through an 80kDa receptor to change protein kinase activity in fibroblasts. Two increases in protein phosphorylation have been identified: the EGF receptor and the small heat shock protein (hsp 27). Both involve serine and are similarly transient (maximal 5-15 minutes). The kinase activity differs from PKA or C. Hsp 27 can be used for its assay in extracts of stimulated cells.
Saklatvala
J
J
Cytokine Biochemistry Department, Strangeways Research Laboratory, Cambridge, UK.
Guesdon
F
F
D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology; D015870:Gene Expression; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D011494:Protein Kinases / Q000032:analysis; D017346:Protein Serine-Threonine Kinases; D011971:Receptors, Immunologic / Q000502:physiology; D017472:Receptors, Interleukin-1; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction
D007375:Interleukin-1; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D019204:GTP-Binding Proteins