Loss of leucocyte common antigen (CD45) on atypical lymphocytes in the localized but not disseminated type of Pagetoid reticulosis.
Atypical intraepidermal T cells in Pagetoid reticulosis did not express CD45RO, the low molecular isoform of CD45. These cells did express other CD45 isoforms in the disseminated aggressive variant (Ketron-Goodman type). The complete CD45 family was lost from the cell surface in the benign localized variant (Woringer-Kolopp type). Because the presence of CD45 is crucial for the function of the lymphocyte-specific tyrosine kinase p56lck, which is associated with lymphocyte growth and transformation, this may be the molecular basis for the non-aggressive nature of this clonal T-cell proliferation.
Sterry
W
W
Department of Dermatology, University of Kiel, Germany.
Hauschild
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis*; D004817:Epidermis / Q000276:immunology; D005260:Female; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D017493:Leukocyte Common Antigens; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000276:immunology*; D012871:Skin Diseases / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D006649:Histocompatibility Antigens; D017493:Leukocyte Common Antigens