[Treatment of uncomplicated urinary tract infections: cefuroxime vs cotrimoxazole].
Forty females (ages 15-74) with community-acquired, uncomplicated urinary tract infections were studied. Clinical and microbiological efficacy of cefuroxime (250 mg td) and trimethoprim sulfamethoxazole (160/800 mg td) used for 7 days were evaluated. The microorganisms found in the pre-treatment urinary cultures were: Escherichia Coli (85%), Klebsiella Pneumoniae (12.5%), and E. Agglomerans (2.5%). They were all susceptible to cefuroxime, and 42.5% were resistant to trimethoprim sulfamethoxazole (Kirby-Bauer). These findings show that trimethoprim sulfamethoxazole should not be used empirically while waiting for the results of urinary cultures, and that cefuroxime is a good alternative in these cases. Clinical cure was observed in all, and bacteriological cure in 75% of the pts treated with both antimicrobial agents. Relapses and reinfections were detected during follow-up emphasizing the importance of intra and post-treatment urinary cultures.
Castrillón
M
M
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Chile.
Palma
I
I
Azócar
G
G
Tapia
R
R
Silva
A
A
Pescio
S
S
Aguayo
R
R
Triantafilo
V
V
Contreras
J
J
Thompson
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D002444:Cefuroxime / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*
D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002444:Cefuroxime
Tratamiento de las infecciones del tracto urinario no complicadas: cefuroximo versus cotrimoxazol.