title: Detection and treatment of brucellosis by screening a population at risk.
abstract: Brucellosis presents a difficult diagnostic challenge in view of its protean manifestations, multiple organ involvement and variable clinical course. The purpose of the present study was to determine whether active screening of a population at risk, identified through index cases, would enhance the detection rate of brucellosis and improve treatment. During a 1-month period all 98 individuals sharing risk factors with 4 diagnosed symptomatic cases of brucellosis in one Bedouin town in southern Israel were approached and 86 agreed to undergo screening. Symptomatic brucellosis was found in 8 (9%) of the screened population and an additional 5 (6%) asymptomatic individuals were found to be seropositive. These 13 were followed for 12 months. All symptomatic cases were treated and cured. Of the 5 asymptomatic seropositive individuals 2 showed a further elevation of Brucella antibody titers. One became symptomatic, was treated and was cured. This screening program provided 53% of all reported cases from the Bedouin town during the entire year of the study. Screening a population at risk increased the detection rate of brucellosis and improved the treatment.
authors.affiliation: Rahat Clinic, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Abramson
authors.forename: Z
authors.initials: Z
authors.lastname: Rosenvasser
authors.forename: C
authors.initials: C
authors.lastname: Block
authors.forename: R
authors.initials: R
authors.lastname: Dagan
mesh_terms: D000293:Adolescent; D000328:Adult; D000372:Agglutination Tests; D002006:Brucellosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007557:Israel; D008297:Male; D008403:Mass Screening; D011159:Population Surveillance; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012698:Serologic Tests