title: Efficacy of coarse-spray administration of a reovirus vaccine in young chickens.
abstract: Coarse-spray (CS) administration of a commercial S1133 reovirus vaccine in chickens for prevention of clinical viral tenosynovitis (VT) infection was evaluated. In Expt. 1, one-day-old specific-pathogen-free (SPF) white leghorns were vaccinated with a combination of reovirus, Newcastle disease (ND), and infectious bronchitis (IB) vaccines by CS and infectious bursal disease vaccine by the subcutaneous (SQ) route. In Expt. 2, one-day-old commercial broilers were vaccinated by CS with reovirus vaccine and Marek's disease (MD) vaccine by SQ. In Expt. 3, one-day-old commercial broilers received reovirus vaccine in combination with ND-IB vaccines at 1 day of age by CS and MD vaccine by SQ. Some birds received an initial or second vaccination at 7 days of age by CS or the drinking-water (DW) route. Birds vaccinated by CS at 1 day of age with reovirus vaccine did not produce circulating virus-neutralizing antibody against reovirus, although they had resistance to VT infection. In contrast, initial or booster vaccination at 7 days of age by CS or DW resulted in an antibody response and greater resistance to challenge than did CS vaccination at 1 day of age. There was no difference in efficacy between CS and DW routes at 7 days of age. The reovirus vaccine did not interfere with other vaccines as measured by serologic (ND-IB-IBD) or challenge (MD) studies.
authors.affiliation: Poultry Science Department, Auburn University, Alabama 36849-5416.
authors.forename: J J
authors.initials: JJ
authors.lastname: Giambrone
authors.forename: T L
authors.initials: TL
authors.lastname: Hathcock
mesh_terms: D000281:Administration, Intranasal; D000336:Aerosols; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002645:Chickens; D008381:Herpesvirus 2, Gallid / Q000276:immunology; D007117:Immunization, Secondary / Q000662:veterinary; D001351:Infectious bronchitis virus / Q000276:immunology; D007243:Infectious bursal disease virus / Q000276:immunology; D007279:Injections, Subcutaneous / Q000662:veterinary; D009522:Newcastle disease virus / Q000276:immunology; D011201:Poultry Diseases / Q000517:prevention & control*; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013717:Tenosynovitis / Q000517:prevention & control / Q000662:veterinary; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000336:Aerosols; D000914:Antibodies, Viral; D014765:Viral Vaccines