A study of short term lipoprotein changes induced by single high cholesterol diet in healthy and diseases human volunteers.
Changes in lipid lipoprotein profile were observed in the first and third hours after feeding 750 mg of egg cholesterol in 13 healthy male subjects (Group A), 6 patients of coronary artery disease (Group B), 10 diabetic patients (Group C), and 10 hypertensive patients (Group D), all belonging to the age group of 35-60 years. 61.53% of healthy male subjects showed a fall in the total serum cholesterol (STC) in the first hour after feeding, while in the rest there was a rise. On the other hand, 66.67% of coronary artery disease patients, 50% of diabetics and 50% hypertensives showed a rise in the first hour while the rest showed either a fall or no change in STC. All groups showed a fall in LDL at the first hour. In the third hour the STC and LDL level increased in group A, C and D, whereas in group B STC showed a fall and LDL showed a rise. All these changes were, however, statistically insignificant. The changes in HDL values were also statistically insignificant except in group D where they showed a progressive rise increase in the first and third hours.
Arora
R C
RC
Dept. of Medicine, MLB Medical College, Jhansi, India.
Agarwal
N
N
Singh
D K
DK
D000328:Adult; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D003327:Coronary Disease / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides