Central 5HT1A-receptor binding in normotensive and spontaneously hypertensive rats.
Central 5HT1A-receptors have been found with a high density in brainstem and are involved in cardiovascular control. The high-affinity binding of [3H]-8-OH-DPAT, a specific 5HT1A-receptor ligand, was measured in medulla oblongata of normotensive and spontaneously hypertensive rats (SHR). The maximal number of [3H]-8-OH-DPAT binding site (Bmax) was significantly increased in SHR when compared to normotensive rats. Whether central 5HT1A-receptors are involved in the etiology of hypertension or are influenced by other neurochemical events remains to be investigated.
Huguet
F
F
INSERM U 316, Laboratoire de Biophysique Médicale, Faculté de Médecine, Tours, France.
Brisac
A M
AM
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011985:Receptors, Serotonin / Q000032:analysis / Q000378:metabolism*; D013764:Tetrahydronaphthalenes / Q000378:metabolism*
D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin