Acute peripheral facial palsy: CSF findings and etiology.
CSF and serum were examined in acute and convalescence phase from 56 patients with acute idiopathic peripheral facial palsy. CSF protein analysis, viral and borrelia serology were performed. Borrelia infection was found in 9/56 cases and was often associated with inflammatory CSF findings. One patient each had serological evidence for a recent or ongoing infection with herpes simplex, varicella zoster, adeno, influenza B, echo and Epstein-Barr virus, but none had specific intrathecal antibody synthesis; 11 patients had a serological pattern compatible with a reactivated Epstein-Barr virus infection. Eleven patients displayed mononuclear CSF pleocytosis. Four of them had a borrelia infection. A disturbed blood-brain barrier was observed in 19 patients. Intrathecal immunoglobulin synthesis as indicated by elevated IgM-indices was found in 16 patients and by IgG indices in three. Nine patients had oligoclonal IgG bands in serum and CSF, three exclusively in CSF. It is concluded that patients with facial palsy often have inflammatory CSF findings, indicating a generalised central nervous system affection, and not only a mononeuritis. The importance of viral infections in the pathogenesis is still obscure. Borrelia is the most common infectious cause of facial palsy.
Roberg
M
M
Department of Infectious Diseases, Linköping University, Sweden.
Ernerudh
J
J
Forsberg
P
P
Fridell
E
E
Frydén
A
A
Hydén
D
D
Linde
A
A
Odkvist
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid*; D000914:Antibodies, Viral / Q000134:cerebrospinal fluid*; D015748:Borrelia burgdorferi Group / Q000276:immunology; D002648:Child; D005158:Facial Paralysis / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011115:Polyneuropathies / Q000276:immunology*; D012709:Serum Albumin / Q000134:cerebrospinal fluid
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D007136:Immunoglobulins; D012709:Serum Albumin