Radiolabelled granulocytes in inflammatory bone disease.
Inflammatory lesions in 7 patients have been investigated using labelled in vivo granulocytes. Targeting of white cells was done with a monoclonal antibody, mouse IgG1 reacting with NCA (non-specific crossreacting antigen) and CEA (carcinoembryonic antigen) (BW 250/183) labelled with 99mTc. All inflammatory lesions were visualized, with excellent quality scintigram, between 3-6 and 24 h after the injection. Because the antibody can be stored in a freeze-dried form and labelled at any time with 99mTc without cell separation being necessary, the method appears to be suitable even for use in acute diagnosis.
D'Amico
P
P
Department of Nuclear Medicine, University of Naples, Italy.
Lastoria
S
S
Caccavella
N
N
Salvatore
M
M
D000911:Antibodies, Monoclonal; D001170:Arthritis, Infectious / Q000000981:diagnostic imaging* / Q000276:immunology; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D010019:Osteomyelitis / Q000000981:diagnostic imaging* / Q000276:immunology; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m
D000911:Antibodies, Monoclonal; D013670:Sodium Pertechnetate Tc 99m