Teicoplanin does not modify the hypoglycemic effects of phenformin or glibenclamide, nor the anticoagulant action of warfarin. Experimental study.
Eventual pharmacological interactions induced by teicoplanin administration associated with oral hypoglycemic (phenformin and glibenclamide) and oral anticoagulant (warfarin) drugs have been experimentally evaluated. The administration of teicoplanin (3-15 mg/kg/die by endoperitoneal route) to the rat for 4 days did not significantly (P greater than 0.05) modify glycemia, prothrombin and partial thromboplastin times, the hypoglycemic effect of phenformin (2.5 mg/kg/die/4 days) or glibenclamide (0.5 mg/kg/die/4 days) nor the anticoagulant effect of warfarin (0.5 mg/kg/die/4 days). In conclusion, our results document that teicoplanin does not interfere with the activity of phenformin, glibenclamide or sodium warfarin.
Rossi
F
F
Institute of Pharmacology and Toxicology, 1st Faculty of Medicine and Surgery, University of Naples Federico II, Italy.
Marrazzo
R
R
Lucarelli
C
C
Marabese
I
I
De Santis
D
D
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004347:Drug Interactions; D005260:Female; D005905:Glyburide / Q000008:administration & dosage / Q000494:pharmacology*; D006020:Glycopeptides / Q000008:administration & dosage / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007441:Intubation, Gastrointestinal; D008297:Male; D010314:Partial Thromboplastin Time; D010629:Phenformin / Q000008:administration & dosage / Q000494:pharmacology*; D011517:Prothrombin Time; D051381:Rats; D011919:Rats, Inbred Strains; D017334:Teicoplanin; D014859:Warfarin / Q000494:pharmacology*
D001786:Blood Glucose; D006020:Glycopeptides; D014859:Warfarin; D017334:Teicoplanin; D010629:Phenformin; D005905:Glyburide