[Suppressive effects of safflower yellow on immune functions].
Safflower yellow (SY) extracted from Carthamus tinctorius L contained chalconoid compounds, 75% of which was safflomin A. SY ip 50-450 mg.kg-1.d-1 x 6-8 d in mice decreased serum lysozyme concentration and phagocytosing functions of both peritoneal macrophages and peripheral leukocytes; diminished the production of plaque forming cells, specific rosette forming cells, and antibody; inhibited delayed type hypersensitivity reaction and the activation of T suppressor cells elicited by supraoptimal immunization. Experiments in vitro showed inhibitory effects on [3H]TdR incorporation during human peripheral T- and B-lymphocyte proliferation by SY 0.03-3.0, 0.1-2.0 mg.ml-1 respectively, murine mixed lymphocyte culture response and the production of interleukin-2 by SY 0.1-2.5 mg.ml-1. In conclusion, SY produced declines in both nonspecific and specific immune functions.
Lu
Z W
ZW
Department of Pharmacology, Xinjiang Medical College, Urumqi, China.
Liu
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Hu
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Bian
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Li
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FG
D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007376:Interleukin-2 / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009113:Muramidase / Q000097:blood; D010587:Phagocytosis / Q000187:drug effects; D012397:Rosette Formation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007166:Immunosuppressive Agents; D007376:Interleukin-2; C076422:safflower yellow; D002599:Chalcone; D009113:Muramidase