Immunohistochemistry in the differential diagnosis of tumours of possible myogenic origin.
A series of 34 cases of soft tissue tumours of possible muscle origin was studied immunohistochemically using different antibodies. Tissue specimens and/or aspirates from fine needle aspiration biopsy (FNAB) were examined. The results indicate that immunohistochemistry is a valuable tool in differential diagnosis of soft tissue tumours, improving diagnostic accuracy in 83.5% of the examined cases. Desmin expression confirmed muscle differentiation of tumours in 47.6% of diagnostically difficult cases. The application of immunohistochemistry may be especially helpful in rendering the diagnosis of tumour type more precise when a needle aspirate is the only available diagnostic material.
Szadowska
A
A
Department of Oncology, School of Medicine, Lódź.
Lasota
J
J
Mirecka
B
B
Giryn
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003893:Desmin / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D007223:Infant; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D003893:Desmin; D014746:Vimentin