title: Skin aging. Effect on transepidermal water loss, stratum corneum hydration, skin surface pH, and casual sebum content.
abstract: This study investigates the effect of cutaneous aging on transepidermal water loss, stratum corneum hydration (capacitance), skin surface pH, and causal sebum content. Because the physiologic condition of skin varies considerably with anatomic region and skin aging might demonstrate regional variability, all factors were studied on 11 anatomic locations in 14 young adult (seven female and seven male subjects; 26.7 +/- 2.8 years [mean +/- SD]) and 15 aged human volunteers (seven female and seven male subjects; 70.5 +/- 13.8 years). Significant anatomic variability was noted for all factors in both age groups. However, no significant differences between the two groups were noted for sebum, capacitance, and pH on most anatomic regions. Transepidermal water loss, however, was significantly lower in the aged population on all anatomic regions tested, except for the postauricular region and the palm. Comparing male and female volunteers, none of the four factors showed significant differences. Of all measured factors, only transepidermal water loss showed significant age-related differences on most anatomic regions studied. The additionally observed differences between the age groups on the ankle for pH and sebum might be related to the stasis frequently observed on the lower limbs in aged individuals.
authors.affiliation: Department of Dermatology, University of California-San Francisco, School of Medicine 94143-0989.
authors.forename: K P
authors.initials: KP
authors.lastname: Wilhelm
authors.forename: A B
authors.initials: AB
authors.lastname: Cua
authors.forename: H I
authors.initials: HI
authors.lastname: Maibach
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D001834:Body Water / Q000378:metabolism*; D005260:Female; D005712:Galvanic Skin Response; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D012629:Sebum / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D015595:Skin Aging / Q000502:physiology*; D014870:Water Loss, Insensible