Chronic treatment with vasopressin analogues alters affinity of vasopressin receptors in the septum and amygdala of the rat brain.
Accurel devices were used to administer AVP or AVP-antagonist into the lateral ventricle of the rat brain for 7 days. Neither AVP nor antagonist altered total binding site concentration in either septum or amygdala. However, treatment with antagonist caused a marked decrease in the affinity of the receptor for agonist in both the septum and amygdala.
Swank
M W
MW
Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, Seattle, WA 98108.
Dorsa
D M
DM
D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives; D008297:Male; D051381:Rats; D011945:Receptors, Angiotensin / Q000187:drug effects / Q000378:metabolism*; D017483:Receptors, Vasopressin; D012688:Septum Pellucidum / Q000378:metabolism*
D011945:Receptors, Angiotensin; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; C025043:vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-