title: [131I]metaiodobenzylguanidine therapy in advanced neuroblastoma.
abstract: Forty-two children with advanced neuroblastoma who either failed with first-line therapy or relapsed after achieving a complete remission, were considered for treatment with [131I]metaiodobenzylguanidine (131I-MIBG). We subdivided 42 cases into 5 groups, in accordance with the stage of disease at diagnosis, response to first-line therapy and relapse. A total of 99 courses of 131I-MIBG were administered with doses ranging from 2.8 to 6.0 GBq. One child received six courses, 3 four courses, 18 three courses, 6 two courses and 15 one course of 131I-MIBG. The total delivered dose in single measurable lesions ranged from 286 to 1691 cGy with an uptake factor ranging from 3% to 10%. We obtained a major response in primary tumors, and a long-term response was observed in 5 cases, lasting more than 2 years without further chemotherapy.
authors.affiliation: Nuclear Medicine Service, Ospedale Galliera, Genoa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Claudiani
authors.forename: A
authors.initials: A
authors.lastname: Garaventa
authors.forename: L
authors.initials: L
authors.lastname: Bertolazzi
authors.forename: G P
authors.initials: GP
authors.lastname: Villavecchia
authors.forename: M
authors.initials: M
authors.lastname: Cabria
authors.forename: G
authors.initials: G
authors.lastname: Scopinaro
authors.forename: M
authors.initials: M
authors.lastname: Bestagno
authors.forename: P
authors.initials: P
authors.lastname: Guerra
authors.forename: N
authors.initials: N
authors.lastname: Canevarollo
authors.forename: G
authors.initials: G
authors.lastname: Scielzo
mesh_terms: D019797:3-Iodobenzylguanidine; D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000627:therapeutic use*; D008297:Male; D009447:Neuroblastoma / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine