Fixed drug eruption from pamabrom.
A young woman presented with recurrent skin lesions that were predominantly perioral. Fixed drug reaction was diagnosed based on her history of intermittent ingestion of Pamprin, a common menstrual symptom reliever, and characteristic erythematous, pigmented, edematous patches. After oral challenge with two of the three ingredients in Pamprin, a diagnosis of fixed drug reaction to pamabrom was made. Pamabrom is a mild diuretic present in several over-the-counter and prescription menstrual symptom relievers. This is the first reported case of fixed drug reaction to pamabrom.
Nedorost
S
S
Department of Dermatology, Cleveland Clinic Foundation, Ohio 44195.
Taylor
J S
JS
Camisa
C
C
Tomecki
K J
KJ
Helm
T
T
Durkin
W J
WJ
D000328:Adult; D004338:Drug Combinations; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects; D011412:Propanolamines / Q000009:adverse effects* / Q000627:therapeutic use; D012883:Skin Ulcer / Q000139:chemically induced*; D013806:Theophylline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D004338:Drug Combinations; D011412:Propanolamines; D013806:Theophylline; C069987:pamabrom