Isradipine, a calcium antagonist, in the control of hypertension following coronary artery-bypass surgery.
Arterial hypertension is common after coronary artery-bypass grafting (CABG) surgery and may lead to postoperative complications. Therefore, the effects of the calcium antagonist isradipine were studied in 10 postoperative CABG patients who had a mean arterial pressure (MAP) above 100 mm Hg. Isradipine, given as a continuous infusion, reduced MAP to the range of 85 +/- 5 mm Hg in all patients within 15 min. Systemic vascular resistance fell and cardiac output increased in all patients. A slight increase in heart rate was seen in some, but not all, patients. There were no adverse effects. In conclusion, isradipine appears to be a useful agent in the treatment of postoperative hypertension following CABG surgery.
Lawrence
C J
CJ
Department of Anesthesiology, University Hospital of Maastricht, The Netherlands.
Lestrade
A
A
de Lange
S
S
D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002302:Cardiac Output / Q000187:drug effects; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D017275:Isradipine; D011184:Postoperative Period; D011725:Pyridines / Q000627:therapeutic use*; D014655:Vascular Resistance / Q000187:drug effects
D002121:Calcium Channel Blockers; D011725:Pyridines; D017275:Isradipine