title: [Increase of incidence of Down syndrome and its possible relation with increased maternal age].
abstract: Among 47,458 consecutive births taking place between july 1977 and december 1989, we found 83 newborns with Down syndrome, for a 1.74/1000 live births incidence rate. This compares to a rate of 1.39 rate observed at the same maternity from 1971 to 1977 (NS). The mean age of all mothers was 25.9 years as compared to 31.87 for mothers of children with Down syndrome (p < 0.00001). The mean maternal age has increased from 24.34 in 1977 to 27.38 in 1988 (p < 0.0001), mostly due to a greater proportion of the 25 to 29 year-old group of mothers. These data support, although not conclusively, that the increased incidence of Down syndrome in our population is related to older maternal age.
authors.affiliation: Departamento de Obstetricia y Ginecología Norte, Facultad de Medicina, Hospital Clínico de la Universidad de Chile.
authors.forename: J
authors.initials: J
authors.lastname: Nazer
authors.forename: M E
authors.initials: ME
authors.lastname: Hubner
authors.forename: L
authors.initials: L
authors.lastname: Cifuentes
authors.forename: R
authors.initials: R
authors.lastname: Ramírez
authors.forename: J
authors.initials: J
authors.lastname: Catalán
authors.forename: G
authors.initials: G
authors.lastname: Ruiz
mesh_terms: D000293:Adolescent; D000328:Adult; D004314:Down Syndrome / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D010331:Paternal Age; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011446:Prospective Studies
vernacular_title: Aumento de la incidencia del síndrome de Down y su posible relación con el incremento de la edad materna.