title: The use of continuous subcutaneous octreotide infusion in brittle type 1 diabetic patients.
abstract: Two Type 1 diabetic patients with brittle diabetes were successfully treated using continuous SC octreotide (Sandostatin) infusion (200 micrograms 24-h-1) for 6 months and 12 months. When the analogue was discontinued, rapid deterioration in glucose control and ketonuria recurred in one patient and diabetic ketoacidosis in the other. These were corrected after reinstitution of the analogue.
authors.affiliation: Department of Internal Medicine, Ohio State University Hospitals, Columbus.
authors.forename: F
authors.initials: F
authors.lastname: Bello
authors.forename: J M
authors.initials: JM
authors.lastname: Falko
authors.forename: T M
authors.initials: TM
authors.lastname: O'Dorisio
authors.forename: K
authors.initials: K
authors.lastname: Osei
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D016883:Diabetic Ketoacidosis / Q000517:prevention & control; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007328:Insulin / Q000627:therapeutic use; D007657:Ketone Bodies / Q000652:urine; D009765:Obesity; D015282:Octreotide / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007657:Ketone Bodies; D015282:Octreotide