Accumulation of quinolinic acid in uremic serum and its removal by hemodialysis.
Quinolinic acid was first identified in uremic serum by use of gas chromatography/mass spectrometry. Quantification by selected ion monitoring revealed that the serum concentration of quinolinic acid was markedly increased in chronic hemodialysis patients, and that the acid could be removed by conventional hemodialysis. The serum concentration of quinolinic acid was weakly but significantly correlated with the serum uric acid concentration. Accumulation of quinolinic acid in uremic blood may be involved in the pathogenesis of anemia, suppressed immune system, and uremic encephalopathy.
Niwa
T
T
Department of Internal Medicine, Nagoya University Branch Hospital, Japan.
Yoshizumi
H
H
Emoto
Y
Y
Miyazaki
T
T
Hashimoto
N
N
Takeda
N
N
Tatematsu
A
A
Maeda
K
K
D000328:Adult; D000368:Aged; D003292:Convulsants / Q000097:blood; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000097:blood*; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism* / Q000628:therapy
D003292:Convulsants; D011805:Quinolinic Acids; D017378:Quinolinic Acid