Subchronic buspirone, mesulergine, and ICS 205-930 lack effects on D1 and D2 dopamine binding in the rat striatum during chronic haloperidol treatment.
We administered the serotonergic agents buspirone, mesulergine and ICS 205-930 during the last two weeks of a 4-week oral haloperidol chronic treatment regimen and determined dopamine receptor binding and apomorphine-induced stereotypic activity after a drug washout period. D1 receptor binding was not affected by any treatment. Chronic haloperidol treatment produced a significant increase in the density of D2 receptors for all groups, including the groups that were administered combination treatment of haloperidol and serotonergic compounds. Apomorphine-induced stereotypic activity measured 4 days after the last haloperidol treatment was elevated to the same extent for all haloperidol treated groups. Contrary to a previous report, subchronic treatment with buspirone did not significantly reverse neuroleptic-induced D2 receptor up-regulation.
Young
K A
KA
Department of Medical Pharmacology and Toxicology, Texas A&M College of Medicine.
Zavodny
R
R
Hicks
P B
PB
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002065:Buspirone / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004873:Ergolines / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects; D000077526:Tropisetron; D015854:Up-Regulation / Q000187:drug effects
D004873:Ergolines; D007211:Indoles; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D012702:Serotonin Antagonists; D000077526:Tropisetron; D006220:Haloperidol; D001058:Apomorphine; C031649:mesulergine; D002065:Buspirone