Antiproliferative activity of retinoids, interferon alpha and their combination in five human transformed cell lines.
Tretinoin, isotretinoin and acitretin were examined for their capacity to modulate the proliferation of the cell lines: HL-60 (acute promyelocytic leukemia), MCF7 (mammary carcinoma), SCC4, SCC15 and A431 (squamous cell carcinomas). Retinoids inhibited proliferation to a varying extent in all 5 cell lines. The cytokine IFN alpha had a significant antiproliferative effect only on HL-60, SCC4 and SCC15. The combination of retinoids with IFN alpha led in all 5 cell lines to a more profound reduction in proliferation than either retinoids or IFN alpha alone.
Frey
J R
JR
Pharmaceutical Research, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Peck
R
R
Bollag
W
W
D017255:Acitretin; D002455:Cell Division / Q000187:drug effects*; D004357:Drug Synergism; D006131:Growth Inhibitors; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000008:administration & dosage*; D015474:Isotretinoin / Q000494:pharmacology; D012176:Retinoids / Q000008:administration & dosage*; D014212:Tretinoin / Q000031:analogs & derivatives / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D006131:Growth Inhibitors; D007370:Interferon Type I; D012176:Retinoids; D014212:Tretinoin; D015474:Isotretinoin; D017255:Acitretin