[Autologous bone marrow transplantation in acute myeloid leukemias: a report of 7 cases].
Seven patients with acute myeloid leukemias (AML) in complete remission (CR) were treated with high dose chemotherapy and/or total body irradiation (TBI) followed by autologous bone marrow transplantation (ABMT). The clinical status of the 7 cases at ABMT were as follows: 5 in CR1 (2 with standard risks and 3 with high risks) and 2 in CR2 (both with standard risks). The conditioning regimens used for ABMT were cyclophosphamide plus TBI in 3 cases, high dose busulfan plus cyclophosphamide in 3 cases, and BACT program chemotherapy in 1 case. All 7 cases showed hemopoietic reconstitution after ABMT; no death occurred within the post-transplantation aplasia period, but hepatotoxicity was observed with high dose busulfan. Up to December, 1989, 2 patients in CR1 with standard risk receiving transplants had survived, disease free, for 26 and 18 months, respectively; one of 2 patients in CR2 with standard risk receiving transplants had survived for 30 months, and the other died at the 9th month after ABMT with no sign of leukemia relapse. Two of the 3 patients with high risk relapsed at 5 months post-ABMT and the third was in continuous CR for 5.5 months.
Yan
W
W
Hospital of Blood Diseases, Tianjin.
D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000601:surgery; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D015479:Leukemia, Myelomonocytic, Acute / Q000601:surgery; D008297:Male; D014182:Transplantation, Autologous