title: Acne: current concepts of pathogenesis and approach to rational treatment.
abstract: Acne is a skin disorder of the sebaceous follicles that commonly occurs in adolescence and young adulthood. The pathogenesis involves abnormal follicular hyperkeratosis and obstruction of the follicle, stimulation of sebaceous gland secretion by androgens, and proliferation of Propionibacterium acnes, which promotes inflammation. Treatment regimens should be designed based upon an understanding of the multifactorial basis of pathogenesis. Both topical and systemic agents may be employed to normalize keratinization, decrease sebaceous gland activity, decrease the follicular P. acnes population, and minimize inflammation.
authors.affiliation: Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: L F
authors.initials: LF
authors.lastname: Eichenfield
authors.forename: J J
authors.initials: JJ
authors.lastname: Leyden
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D000279:Administration, Cutaneous; D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000627:therapeutic use; D012627:Sebaceous Glands / Q000503:physiopathology; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D005938:Glucocorticoids; D014212:Tretinoin; D015474:Isotretinoin; D001585:Benzoyl Peroxide