Fatal overdose of amphotericin B in two preterm infants.
Two premature infants exhibited an acute cardiorespiratory collapse shortly after receiving a 50-fold overdose of amphotericin B (AmB). Despite aggressive intervention both infants died. Serum AmB levels were double the normal therapeutic range. We speculate that two less well-recognized toxic complications of AmB involving the cardiac and respiratory systems may have contributed to the fatal outcome.
Perlman
J M
JM
Department of Pediatrics, UT Southwestern Medical Center, Dallas.
Acarregui
M
M
Gard
J W
JW
D000293:Adolescent; D000666:Amphotericin B / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male
D000666:Amphotericin B