title: Sulfadimethoxine residue in broiler-chicken skin.
abstract: The disposition and elimination of sulfadimethoxine (SDMX) in the skin of broiler-chickens were investigated. The administration of SDMX, in drinking water, at a concentration of 1,000 ppm for 5 days demonstrated that the SDMX was eliminated much more slowly from the skin than from the other tissues or plasma. These results were duplicated and confirmed in another experiment, in which a single dose of 200 mg/kg BW of SDMX was administered via a stomach tube. No significant difference in the SDMX residue level was observed between the broiler-chickens that had their skin surface sealed versus the non-sealed animals and that had ingested SDMX in their drinking water. This illustrated the higher SDMX residue in the skin was not attributable to external SDMX contamination from the drinking water, feces or urine. In addition, there was no significant difference among the SDMX residue concentrations in the thoracic, dorsal and leg skin samples, following an intravenous injection of SDMX (30 mg/kg BW). This indicated that the SDMX was distributed evenly throughout the entire skin area of the broiler-chickens.
authors.affiliation: Research Institute for Animal Science in Biochemistry and Toxicology, Kanagawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: A A
authors.initials: AA
authors.lastname: Said
authors.forename: M
authors.initials: M
authors.lastname: Hashizume
authors.forename: Y
authors.initials: Y
authors.lastname: Kido
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002645:Chickens / Q000378:metabolism*; D004326:Drinking; D004350:Drug Residues / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D012867:Skin / Q000378:metabolism*; D013412:Sulfadimethoxine / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D013412:Sulfadimethoxine