title: [Diffuse liver parenchymal diseases: the value of MRI compared to sonography and CT].
abstract: 29 patients with diffuse liver disease were examined by ultrasound, CT and MRI. MRI imaging was performed using T1-and t2-weighted spin-echo-sequences and fast gradient-echo-sequences. The paramagnetic contrast agent Gd-DTPA was applied intravenously (0.1 mmol/kg). In all patients with hepatitis MRI enabled exact liver biopsy by delineation of inflammatory changes in cases of chronic or focal hepatitis. CT and ultrasound were superior to MRI in the detection of focal or diffuse fatty degeneration. However, MRI enabled an exact differentiation of fatty changes from neoplasm. In cases of fibrotic changes the most accurate findings could be shown by MRI. In patients suffering from hemochromatosis MRI supplied additional information compared to CT and ultrasound revealing significant reduction of signal intensity due to reinforced enhancement of iron. Concerning Wilson's disease MRI showed a characteristic pattern of parenchymal changes. The application of Gd-DTPA in cases of diffuse liver disease adds supplementary information about perfusion of liver parenchyma, but its value for diagnostic accuracy is only secondary.
authors.affiliation: Radiologische Klinik Innenstadt, Ludwig-Maximilians-Universität.
authors.forename: T
authors.initials: T
authors.lastname: Vogl
authors.forename: S
authors.initials: S
authors.lastname: Steiner
authors.forename: D
authors.initials: D
authors.lastname: Hahn
authors.forename: H
authors.initials: H
authors.lastname: Schedel
authors.forename: J
authors.initials: J
authors.lastname: Lissner
mesh_terms: D003287:Contrast Media; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA
vernacular_title: Diffuse Leberparenchymerkrankungen: Wertigkeit der KST im Vergleich mit Sonographie und CT.