Determination of sodium and chloride ions in teicoplanin lyophilized vials by nonsuppressed, single-column ion chromatography.
Two nonsuppressed, single-column ion chromatographic procedures have been developed and validated for the determination of the total sodium and chloride ion content in lyophilized vials containing teicoplanin. The assays served to determine the amount of sodium chloride added to the vials and to estimate the amount of sodium associated with the teicoplanin molecule.
de Soto-Perera
M A
MA
Department of Analytical Chemistry, Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.
D000900:Anti-Bacterial Agents / Q000032:analysis; D002712:Chlorides / Q000032:analysis*; D002845:Chromatography / Q000379:methods; D005612:Freeze Drying; D006020:Glycopeptides / Q000032:analysis; D012964:Sodium / Q000032:analysis*; D017334:Teicoplanin
D000900:Anti-Bacterial Agents; D002712:Chlorides; D006020:Glycopeptides; D017334:Teicoplanin; D012964:Sodium