title: Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations.
abstract: Chromosomal region 11q23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from 11q23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;11), t(9;11), and t(11;19) translocations. The breakpoints cluster in a small DNA region of less than 5.8 kilobases.
authors.affiliation: Jefferson Cancer Institute, Jefferson Cancer Center, Philadelphia, Pennsylvania.
authors.forename: G
authors.initials: G
authors.lastname: Cimino
authors.forename: D T
authors.initials: DT
authors.lastname: Moir
authors.forename: O
authors.initials: O
authors.lastname: Canaani
authors.forename: K
authors.initials: K
authors.lastname: Williams
authors.forename: W M
authors.initials: WM
authors.lastname: Crist
authors.forename: S
authors.initials: S
authors.lastname: Katzav
authors.forename: L
authors.initials: L
authors.lastname: Cannizzaro
authors.forename: B
authors.initials: B
authors.lastname: Lange
authors.forename: P C
authors.initials: PC
authors.lastname: Nowell
authors.forename: C M
authors.initials: CM
authors.lastname: Croce
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D015152:Blotting, Northern; D015139:Blotting, Southern; D017252:CD3 Complex; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D002894:Chromosomes, Human, Pair 4; D002899:Chromosomes, Human, Pair 9; D003001:Cloning, Molecular; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D015183:Restriction Mapping; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D004273:DNA, Neoplasm; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D011948:Receptors, Antigen, T-Cell