title: [Heart-lung transplantation and double lung transplantation. 33 cases].
abstract: Between June 1986 and October 1989, 29 heart lung transplantations and 4 double lung transplantations were performed at the Marie Lannelongue Hospital, Paris. The early and later course of these patients was studied. The actuarial survival rates at one and two years were 65 percent and 55 percent respectively. Bacterial infection was the main cause of early death. Late morbidity was predominantly due to cytomegalovirus infection and episodes of rejection. Respiratory function, evaluated in 19 long-term survivors, was usually normal. Only 3 patients developed a functional pattern of severe obliterative bronchiolitis probably related to uncontrolled rejections. The indications of the different types of lung transplantation are discussed: in cases of primary pulmonary hypertension or Eisenmenger's complex, heart lung transplantation is the only possible procedure. In patients with respiratory failure without cardiac dysfunction, double lung transplantation gives good functional results and makes an extra heart available for transplantation in another patient. Single lung transplantation, which gives worse functional results with a similar mortality rate, must be reserved for patients who are unable to undergo double lung transplantation.
authors.affiliation: Groupe de transplantations pulmonaires et cardiopulmonaires de l'Université Paris Sud, Hôpital Marie Lannelongue, Le Plessis-Robinson.
authors.forename: J
authors.initials: J
authors.lastname: Cerrina
authors.forename: E
authors.initials: E
authors.lastname: Bavoux
authors.forename: F
authors.initials: F
authors.lastname: Le Roy Ladurie
authors.forename: D
authors.initials: D
authors.lastname: Lafont
authors.forename: P
authors.initials: P
authors.lastname: Hervé
authors.forename: J P
authors.initials: JP
authors.lastname: Duffet
authors.forename: A
authors.initials: A
authors.lastname: Chapelier
authors.forename: G
authors.initials: G
authors.lastname: Simonneau
authors.forename: P
authors.initials: P
authors.lastname: Vouhé
authors.forename: P
authors.initials: P
authors.lastname: Dartevelle
mesh_terms: D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000209:etiology; D001982:Bronchial Diseases / Q000209:etiology; D002648:Child; D004487:Edema / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D016041:Heart-Lung Transplantation / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D008171:Lung Diseases / Q000209:etiology; D016040:Lung Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D014133:Tracheal Diseases / Q000209:etiology
vernacular_title: Transplantations coeur-poumons et bipulmonaires. 33 cas.