[The role of eicosanoids in regulation of blood circulation and metabolism in the stomach].
The study was carried out on anesthetized dogs to determine the role of eicosanoids in regulation of total, and mucosal gastric blood flow and oxygen consumption in the stomach damaged by the instillation of 25% ethanol. The inhibition of prostaglandins generation by indomethacin caused an ischemia and hypoxia in the stomach. It was an evidence for their basal generation and tonic influence on circulation in this organ. OKY--a blocker of thromboxanes synthesis and NDGA--a blocker of 5-lipoxygenase did not alter circulatory and metabolic parameters in the stomach. Above findings indicate, that thromboxanes and leukotrienes are not involved in the physiological modulation of blood vessels activity and oxygen consumption in the stomach. Administration of 25% ethanol on gastric mucosa affected in a rise of total and mucosal blood flow and oxygen consumption. These effects were significantly potentiated by OKY and NDGA and suggesting, that damaged gastric mucosa is able to generate thromboxanes and leukotrienes which cause vasoconstriction. It seems, that endogenous prostaglandins also play an important role, because the gastric hyperemia and the increase in gastric oxygen consumption after alcohol were inhibited by indomethacin.
Czarnobilski
K
K
Zakładu Fizjologii Doświadczalnej Instytutu Fizjologii Akademii Medycznej im. M. Kopernika, Krakowie.
D000818:Animals; D004285:Dogs; D015777:Eicosanoids / Q000502:physiology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D013270:Stomach / Q000098:blood supply / Q000187:drug effects / Q000502:physiology*
D015777:Eicosanoids; D007213:Indomethacin
Rola eikozanoidów w regulacji krazenia krwi i metabolizmu w zoładku.