title: Idiopathic myelofibrosis: dental treatment considerations.
abstract: Idiopathic myelofibrosis is a myeloproliferative disorder of unknown origin. The bone marrow becomes fibrotic with an associated decrease in hematopoiesis resulting in anemia, bleeding problems, splenomegaly, and other secondary abnormalities. Although idiopathic myelofibrosis is usually diagnosed in middle age, there have been a few reports of the disorder in the pediatric population. This case report documents dental treatment considerations in a 6-year-old female with idiopathic myelofibrosis, severe anemia, and abnormal blood coagulation studies. The patient was successfully treated in a hospital after medical consultation, transfusion of packed red blood cells, and administration of prophylactic antibiotics. Local hemostatic measures following multiple extractions of carious teeth controlled bleeding. No postoperative sequelae occurred.
authors.affiliation: Department of Pediatric Dentistry, West Virginia University, Morgantown 26506.
authors.forename: R
authors.initials: R
authors.lastname: Steelman
authors.forename: D
authors.initials: D
authors.lastname: Holmes
authors.forename: R
authors.initials: R
authors.lastname: Cranston
authors.forename: D
authors.initials: D
authors.lastname: Cupp
mesh_terms: D000740:Anemia; D000766:Anesthesia, Dental; D000769:Anesthesia, Inhalation; D002648:Child; D003730:Dental Care for Persons with Disabilities; D003793:Dental Restoration, Permanent; D005260:Female; D006488:Hemostasis, Surgical; D006801:Humans; D010347:Patient Care Planning; D010482:Periapical Abscess / Q000628:therapy; D055728:Primary Myelofibrosis; D014081:Tooth Extraction