Accumulation of the c-mos protein is correlated with post-natal development of skeletal muscle.
Previously we reported that c-mos proto-oncogene RNA was developmentally up-regulated during post-natal maturation of the rat skeletal muscle. Using two different site-directed affinity-purified antipeptide antibodies we can observe that c-mos product (p43 c-mos) accumulates increasingly during post-natal development of the skeletal muscle and exhibits protein kinase activity. We find that in adult rat p43 c-mos is 10-fold higher in skeletal muscle than in ovaries, and 20- to 40-fold higher than in heart, lung, testis and liver, and may represent about 0.005% of the total soluble proteins. In addition adult skeletal muscle from Xenopus, mouse and man was found to contain p43 c-mos. These data argue in favour of a novel muscle-specific function of c-mos.
Leibovitch
S A
SA
Laboratoire d'Oncologie Moléculaire UA1158, URA 126 du CNRS Institut Gustave Roussy, Villejuif, France.
Guillier
M
M
Lenormand
J L
JL
Leibovitch
M P
MP
D000375:Aging; D000818:Animals; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D024510:Muscle Development; D009132:Muscles / Q000201:enzymology; D010053:Ovary / Q000201:enzymology / Q000254:growth & development; D014176:Protein Biosynthesis; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D017231:Proto-Oncogene Proteins c-mos; D011519:Proto-Oncogenes; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013045:Species Specificity; D014158:Transcription, Genetic; D014981:Xenopus
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D011993:Recombinant Fusion Proteins; D011505:Protein-Tyrosine Kinases; D017231:Proto-Oncogene Proteins c-mos