[Hepatitis C antibodies in children and adolescents with congenital blood coagulation disorders].
Antibodies to hepatitis C (anti-HCV) were determined in 24 children and adolescents with congenital disorders of haemostasis. 13 out of 24 patients (54%) were positive for anti-HCV. Comparison of the prevalence of positive anti-HCV and the quantity of non-virus inactivated factor VIII concentrates administered before 1985 showed positive anti-HCV in 100% of patients receiving more than 300 U factor VIII/kg b.w./month, in 88% of patients receiving 100 to 300 U factor VIII/kg b.w./month, and in 60% of patients receiving less than 100 U/kg b.w./month. 13 out of all 16 patients (81%) treated with non-virus-inactivated concentrates before 1985 were positive for anti-HCV. In contrast, all patients treated with virus inactivated concentrates were negative for anti-HCV. Elevated aminotransferases were frequently found in 8 out of 13 patients (62%) positive for anti-HCV, but only in 3 out of 11 patients (27%) negative for anti-HCV. The risk of developing chronic hepatitis was about 2.5-fold higher in patients positive for hepatitis C-antibodies than in patients negative for hepatitis C-antibodies.
Zenz
W
W
Universitäts-Kinderklinik, Graz.
Hofmann
H
H
Muntean
W
W
D000293:Adolescent; D002648:Child; D005169:Factor VIII / Q000627:therapeutic use; D006467:Hemophilia A / Q000276:immunology* / Q000628:therapy; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000032:analysis*; D006509:Hepatitis B / Q000175:diagnosis / Q000276:immunology / Q000635:transmission; D006510:Hepatitis B Antibodies / Q000032:analysis; D006526:Hepatitis C / Q000175:diagnosis / Q000276:immunology* / Q000635:transmission; D006801:Humans; D008111:Liver Function Tests; D012307:Risk Factors
D006508:Hepatitis Antibodies; D006510:Hepatitis B Antibodies; D005169:Factor VIII
Hepatitis-C-Antikörper bei Kindern und Jugendlichen mit angeborenen Gerinnungsstörungen.