Retinoic acid-induced glandular metaplasia in mouse skin is linked to the dermal expression of retinoic acid receptor beta mRNA.
The distribution of transcripts of nuclear (RAR alpha, RAR beta, and RAR gamma) and cytosolic (CRABP) retinoic acid receptors was analyzed in 13.5-day mouse embryo upper-lip skin, cultured in vitro for 48 hr with or without added retinoic acid. The results show a significant up-regulation of the transcription of the RAR beta gene concomitant with the initiation of an alteration of hair vibrissae follicle development, leading, after transfer for 8 days to the chick embryo chorioallantoic membrane, to an exocrine-type gland morphogenesis.
Viallet
J P
JP
Centre d'Etudes et de Recherches sur les Macromolécules Organisées, Université Joseph Fourier, Grenoble, France.
Ruberte
E
E
du Manoir
S
S
Krust
A
A
Zelent
A
A
Dhouailly
D
D
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects; D006197:Hair / Q000166:cytology / Q000196:embryology; D008679:Metaplasia; D051379:Mice / Q000196:embryology; D009693:Nucleic Acid Hybridization; D009924:Organ Culture Techniques; D012333:RNA, Messenger / Q000235:genetics; D018168:Receptors, Retinoic Acid; D012867:Skin / Q000166:cytology; D012879:Skin Physiological Phenomena; D014212:Tretinoin / Q000494:pharmacology*
D002352:Carrier Proteins; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; D014212:Tretinoin