Bone marrow regeneration after hormonal therapy in patients with bone metastases from prostate carcinoma.
Two patients with prostate carcinoma and bone metastases were treated with hormonal therapy. Radioimmune imaging of bone marrow performed with 99mTc-labeled antigranulocyte antibody BW 250/183 before treatment demonstrated absence of granulopoietic bone marrow in extensive regions of the central and proximal peripheral skeleton, indicating diffuse bone marrow invasion. Bone marrow scans performed after treatment demonstrated presence of granulopoietic bone marrow in these regions, indicating bone marrow regeneration. This finding was consistent with favorable response to treatment.
Berná
L
L
Department of Nuclear Medicine, Hospital de Sant Pau, Barcelona, Spain.
Germá
J R
JR
Estorch
M
M
Torres
G
G
Blanco
R
R
Carrió
I
I
D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000502:physiology*; D001859:Bone Neoplasms / Q000503:physiopathology / Q000556:secondary*; D002064:Buserelin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005485:Flutamide / Q000627:therapeutic use*; D017273:Goserelin; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011877:Radionuclide Imaging; D012038:Regeneration
D000911:Antibodies, Monoclonal; D015609:Organotechnetium Compounds; D017273:Goserelin; D005485:Flutamide; D002064:Buserelin