Responses of neutrophils and lymphocytes in the cold stress: effects of nonsteroid anti-inflammatory drugs.
The cold stress induced in rabbits by lowering their body temperature by 3 degrees C resulted in neutrophilia and a decrease in number of phagocytes and phagocytized bacteria. The stress did not affect the number of lymphocytes and the ability of forming E rosettes by T lymphocytes, but depressed the formation of EAC rosettes by B lymphocytes. This inhibition of neutrophil activity was antagonized completely by acetylsalicylic acid, and substantially by mefenamic acid and indomethacin administered, in doses inhibiting pyrogen-induced fever, either 2.5 h before or 1.5 h after the hypothermia. The drugs did not antagonize the depression of the ability of formation of EAC rosettes.
Garbuliński
T
T
Department of Pharmacology and Toxicology, Agricultural Academy, Wrocław, Poland.
Obmińska-Domoradzka
B
B
Switała
M
M
Debowy
J
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D003080:Cold Temperature; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects; D011817:Rabbits; D013312:Stress, Physiological / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000894:Anti-Inflammatory Agents, Non-Steroidal