title: [Markers of hypercoagulability during pregnancy: thrombin-antithrombin-III complexes and D dimer].
abstract: Pregnancy can be regarded as a secondary hyper-coagulability state. The development of thrombin-anti-thrombin complexes (TATC), D dimer and anti-thrombin III (AT III) was analysed in the present work on 33 pregnant women. A significant increase of the TATC records was found between the first and third trimesters and between the second and third trimesters (p = 0.005 and p = 0.02, respectively). The AT III values were within the normal range. The values of the D dimer increased progressively during pregnancy, but only the figures achieved in the third trimester were statistically significant with respect to the control group (p = 0.14). The increase of TATC and D dimer during pregnancy are considered as hypercoagulability.
authors.affiliation: Servicios de Hematología y Ginecología, Hospital de la Santa Creu i Sant Pau, Barcelona.
authors.forename: M
authors.initials: M
authors.lastname: Senent
authors.forename: J
authors.initials: J
authors.lastname: Bellart
authors.forename: I
authors.initials: I
authors.lastname: Zuazu-Jausoro
authors.forename: A
authors.initials: A
authors.lastname: Oliver
authors.forename: I
authors.initials: I
authors.lastname: Montserrat
authors.forename: L
authors.initials: L
authors.lastname: Ribera
authors.forename: I
authors.initials: I
authors.lastname: Tirado
authors.forename: L
authors.initials: L
authors.lastname: Cabero
authors.forename: J
authors.initials: J
authors.lastname: Fontcuberta
mesh_terms: D000328:Adult; D000990:Antithrombin III / Q000032:analysis*; D001777:Blood Coagulation; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D013917:Thrombin / Q000032:analysis*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D000990:Antithrombin III; D013917:Thrombin
vernacular_title: Marcadores de hipercoagulabilidad durante el embarazo: complejos trombina-antitrombina-III y dímero D.