One-sided or two-sided p values: which most appropriately address the question of drug efficacy?
Whether a one-sided or a two-sided p value should be used for reporting the results of an analysis should be determined by the a priori question the investigation seeks to answer. It is concluded that one-sided p values are appropriate in clinical trials whose objective is to provide definitive, confirmatory evidence of efficacy of pharmaceutical compounds.
Peace
K E
KE
Biopharmaceutical Research Consultants, Inc., Ann Arbor, Michigan 48105.
D001702:Biopharmaceutics / Q000706:statistics & numerical data*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D006801:Humans; D012107:Research Design / Q000706:statistics & numerical data*