[Effect of a catalytic subunit of cAMP-dependent protein kinase on acetylcholine-induced chloride currents in mollusk neurons].
It is shown that the amplitude of ACh-induced chloride currents decreases with introduction of cAMP in dialyzed neurons of Helix pomatia, the rate of desensitization of the acetylcholine receptors (AChR) being insignificantly changed. Introduction of an active catalytic subunit (c.s.) of cAMP-dependent protein kinase (cAMP-PK) mimics this effect. It is supposed that the influence of cAMP on the functional properties of the AChR is mediated by the activation of cAMP-PK and further phosphorylation of the AChR by the catalytic subunits of this protein kinase.
Tarasenko
A N
AN
Diatlov
V A
VA
Kastrikina
T F
TF
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001665:Binding Sites / Q000502:physiology; D002384:Catalysis; D018118:Chloride Channels; D002712:Chlorides / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology*; D006372:Helix, Snails; D008565:Membrane Proteins / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism*
D018118:Chloride Channels; D002712:Chlorides; D008565:Membrane Proteins; D000242:Cyclic AMP; D011494:Protein Kinases; D000109:Acetylcholine
Vliianie kataliticheskoĭ sub"edinitsy tsAMP-zavisimoĭ proteinkinazy na atsetilkholinindutsiruemye khlornye tochki v neĭronakh molliuska.