[Treatment of legionellosis with ofloxacin in kidney transplanted patients. Lack of interaction with cyclosporin A].
Seven cases of legionellosis were observed in a series of 81 renal transplant recipients. In the 6 patients with functional graft, pneumonia occurred 17 days on average after the beginning of transplant rejection treatment. The diagnosis was made by bronchoalveolar lavage: the direct immunofluorescence antigen technique was positive in 5 cases and culture in 6 cases. Legionella pneumophila sero-groups 5 and 1 were identified in one and 5 patients respectively. Six of the 7 patients were treated with ofloxacin. This fluoroquinolone was effective in all cases. It was administered as single therapy in 3 patients and did not interfere with ciclosporin A metabolism. Ofloxacin given in mean doses of 400 mg per day adjusted to renal function proved to be a simple, effective and well tolerated treatment of legionellosis in transplant recipients receiving ciclosporin A.
Wynckel
A
A
Service de Néphrologie, CHU, Reims.
Toupance
O
O
Melin
J P
JP
David
C
C
Lavaud
S
S
Wong
T
T
Lamiable
D
D
Chanard
J
J
D000328:Adult; D003524:Cyclosporins / Q000009:adverse effects / Q000097:blood / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects* / Q000379:methods; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced; D016030:Kidney Transplantation; D007876:Legionellosis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000494:pharmacology / Q000627:therapeutic use*
D003524:Cyclosporins; D015242:Ofloxacin
Traitement des légionelloses par ofloxacine chez le transplanté rénal. Absence d'interférence avec la ciclosporine A.