title: Effects of dietary fibers on nonfasting plasma lipoprotein and apolipoprotein levels in rats.
abstract: This study was undertaken to determine whether selected dietary fibers had an effect on plasma lipoproteins, apolipoproteins and enzymes involved in cholesterol metabolism in rats. Each experimental diet contained 8% dietary fiber by weight; all animals were killed in a nonfasted state. After 4 wk, final body weight and liver cholesterol were similar in fiber-free controls and in rats fed diets containing cellulose, pectin, oat bran or wheat bran. Pectin-fed animals has significantly lower plasma cholesterol, HDL-cholesterol and apolipoprotein A-I levels, and exhibited significantly higher hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity than did the fiber-free control group. In addition, plasma triglyceride concentrations were lowest in pectin-fed animals. These multiple effects on lipid metabolism were not observed when oat bran, containing one-third soluble fiber, was used. Although total plasma cholesterol levels in wheat bran-fed animals were not different from those in the fiber-free controls or the cellulose-oat bran-fed animals, the LDL cholesterol level was significantly higher than in fiber-free controls or pectin-fed animals. This study demonstrate that dietary fibers included in the diet of rats are able to alter nonfasting lipoprotein cholesterol and apolipoproteins and that pectin, a soluble fiber, was most effective in lowering plasma cholesterol levels.
authors.affiliation: Department of Nutrition, University of California, Davis 95616.
authors.forename: P M
authors.initials: PM
authors.lastname: Nishina
authors.forename: B O
authors.initials: BO
authors.lastname: Schneeman
authors.forename: R A
authors.initials: RA
authors.lastname: Freedland
mesh_terms: D000818:Animals; D001053:Apolipoproteins / Q000032:analysis / Q000097:blood*; D002482:Cellulose / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004043:Dietary Fiber / Q000494:pharmacology*; D002523:Edible Grain; D008074:Lipoproteins / Q000032:analysis / Q000097:blood*; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008297:Male; D010368:Pectins / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism; D014908:Triticum
chemical_list: D001053:Apolipoproteins; D004043:Dietary Fiber; D008074:Lipoproteins; D014280:Triglycerides; D010368:Pectins; D002482:Cellulose; D002784:Cholesterol