title: Complete remission in refractory anaplastic adult Wilms' tumor treated with cisplatin and etoposide.
abstract: A 61-year-old woman underwent a left radical nephrectomy for Stage II anaplastic Wilm's tumor. She received no adjuvant therapy. One year later computerized tomography (CT) of the abdomen revealed a mass in the left renal fossa and retroperitoneal adenopathy. A CT-guided needle biopsy was nondiagnostic. The patient had progressive disease after treatment with dactinomycin, doxorubicin, and vincristine, but achieved a complete response after treatment with cisplatin and etoposide. The therapy of Wilms' tumor in adults is discussed.
authors.affiliation: Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York 10467.
authors.forename: J A
authors.initials: JA
authors.lastname: Sparano
authors.forename: J B
authors.initials: JB
authors.lastname: Beckwith
authors.forename: S
authors.initials: S
authors.lastname: Mitsudo
authors.forename: P H
authors.initials: PH
authors.lastname: Wiernik
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009392:Nephrectomy; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D009396:Wilms Tumor / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery
chemical_list: D005047:Etoposide; D002945:Cisplatin