A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.
Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates that the mitogen is a new member of the epidermal growth factor (EGF) family. This heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma cells and smooth muscle cells, but is a far more potent mitogen for smooth muscle cells than is EGF. HB-EGF is also expressed in cultured human macrophages and may be involved in macrophage-mediated cellular proliferation.
Higashiyama
S
S
Department of Surgical Research, Children's Hospital, Boston, MA 02115.
Abraham
J A
JA
Miller
J
J
Fiddes
J C
JC
Klagsbrun
M
M
D000595:Amino Acid Sequence; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002846:Chromatography, Affinity; D002851:Chromatography, High Pressure Liquid; D004261:DNA Replication / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D066246:ErbB Receptors / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism*; D006493:Heparin / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008264:Macrophages / Q000378:metabolism*; D008969:Molecular Sequence Data; D011485:Protein Binding; D012689:Sequence Homology, Nucleic Acid
D006133:Growth Substances; D004815:Epidermal Growth Factor; D006493:Heparin; D066246:ErbB Receptors