title: 2D crystal forms of annexin IV on lipid monolayers.
abstract: Two-dimensional crystalline arrays of annexin IV were generated by interaction of the purified protein with a phospholipid monolayer. Image analysis of electron micrographs of the protein crystals, which diffracted to 3.5 nm respectively, revealed p6 and p3 symmetry. Annexin IV gave two crystal forms with unit cells of 18 x 18 nm and 28 x 28 nm. The former unit cell was similar to a previously described form of annexin VI. The implications of these observations are discussed.
authors.affiliation: Imperial Cancer Research Fund Laboratories, London, UK.
authors.forename: R H
authors.initials: RH
authors.lastname: Newman
authors.forename: K
authors.initials: K
authors.lastname: Leonard
authors.forename: M J
authors.initials: MJ
authors.lastname: Crumpton
mesh_terms: D017302:Annexins; D003460:Crystallization; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008055:Lipids / Q000737:chemistry*; D008854:Microscopy, Electron; D011257:Pregnancy Proteins / Q000737:chemistry* / Q000648:ultrastructure; D011487:Protein Conformation
chemical_list: D017302:Annexins; D008055:Lipids; D011257:Pregnancy Proteins