[Energy metabolism and experimental malignant tumor development].
Weight loss in cancer can be attributed to anorexia and/or increased energy expenditure. In order to understand the contribution of these variables, 36 Wistar rats fed regular diet were randomly distributed in 3 groups: T (12) bearing Walker 256 carcinosarcoma; PF (12) pair fed with T group and C (12) as control group; another group--D (12)--in which rats were fed with low protein (1%) diet. Caloric intake, body and tumor weight were measured daily. Indirect calorimetry was done sequentially each 4 days. After 2 weeks of tumor growth there was significant reduction of caloric intake and carcass weight in T group compared to those of C group. There was no difference in carcass weight between T and PF group. After 3 weeks it was significantly reduced in T group (55.7 Kcal/m2/h against 75.0 of N and 65.1 of PF group). Walker 256 carcinosarcoma is an hypometabolic tumor and the host weight loss associated to its development is due to anorexia.
Lima-Gonçalves
E
E
Laboratório de Metabologia Cirúrgica, Faculdade de Medicina da Universidade de S. Paulo.
Waitzberg
D L
DL
Yamada
T M
TM
Auricchio
M T
MT
Weg
R
R
D000818:Animals; D001835:Body Weight; D002153:Calorimetry, Indirect; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage; D004734:Energy Metabolism; D008297:Male; D011502:Protein-Energy Malnutrition / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015431:Weight Loss
D004044:Dietary Proteins
Metabolismo energético e desenvolvimento de tumor malígno experimental.