The prevention of cisplatin-induced renal dysfunction by hydroxyl-containing dithiocarbamates.
Two hydroxyl containing dithiocarbamates, sodium N-methyl-D-glucamine dithiocarbamate (NaG) and sodium dihydroxyethyl dithiocarbamate (NaY) have been examined as agents for the control of the renal dysfunction in rats given cisplatin. Of these, NaG was found to be the more effective in controlling such renal dysfunction when administered at 1 and 3 h after 5 mg cisplatin kg-1, i.p. Renal function was examined 5 days after the administration of cisplatin by measurement of serum and urinary levels of creatinine and urea, creatinine clearance, serum and urinary levels of Na+, K+, Mg2+, Ca2+, as well as the concentrations of these ions in the renal medulla and cortex. Treatment of rats given cisplatin with NaG at 1 and 3 h post cisplatin resulted in indices of renal function which were not significantly different from those of animals which had received no cisplatin. The sole difference was found to be a slight increase in renal cortical Na+ concentration.
Reznik
L V
LV
Laboratory of Renal Physiology and Water-Electrolyte Metabolism, Sechenov Institute of Evolutionary Physiology and Biochemistry, USSR Academy of Sciences, Leningrad.
Myazina
E M
EM
Shakchmatova
E I
EI
Gambaryan
S P
SP
Brovtsyn
V K
VK
Natochin
Y V
YV
Jones
M M
MM
D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D004050:Ditiocarb / Q000494:pharmacology* / Q000031:analogs & derivatives; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D010984:Platinum / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000494:pharmacology; D013113:Spin Labels; D013859:Thiocarbamates / Q000494:pharmacology*
D004573:Electrolytes; D013113:Spin Labels; D013859:Thiocarbamates; D010984:Platinum; D013012:Sorbitol; C041262:N-methyl-D-glucamine dithiocarbamate; D004050:Ditiocarb; C039353:dihydroxyethyldithiocarbamate; D002945:Cisplatin