[Comparative pharmacokinetics of triclabendazole in camels and sheep].
The authors describe the compared pharmacokinetics of triclabendazole in three camels and four sheep which were given orally a single dose of 10 mg/kg liveweight. Plasma concentrations of triclabendazole and its main metabolites were determined by high performance liquid chromatography. No parental drug was detected in the blood plasma due to a hepatic first passage effect. It appeared that there was a major difference between the two species, triclabendazole sulfoxide concentrations being two times lower in camels than in sheep.
Oukessou
M
M
Institut Agro-vétérinaire Hassan II, Rabat, Maroc.
Toutain
P L
PL
Galtier
P
P
Alvinerie
M
M
D000818:Animals; D000871:Anthelmintics / Q000493:pharmacokinetics*; D001562:Benzimidazoles / Q000493:pharmacokinetics*; D002162:Camelus / Q000097:blood / Q000378:metabolism*; D012756:Sheep / Q000097:blood / Q000378:metabolism*; D000077682:Triclabendazole
D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole
Etude pharmacocinétique comparée du triclabendazole chez le mouton et le dromadaire.