[New process for screening of drugs in experimental infection with Trypanosoma cruzi].
We propose a screening process for detection of therapeutic activity of drugs against experimental infection with Trypanosoma cruzi. It is based on the use of infected triatominae that are fed on mice which have received the study drug. Blood meals are made at different time schedule in order to adapt with serum drug levels. The digestive tube of the hemiptera will, thus, work as a suitable structure for examination. In a initial observation, benzonidazole was used, and was shown to be only partially active at least in the conditions of this new procedure.
Campos
R
R
Laboratório de Investigação Médica-Parasitologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brasil.
Amato Neto
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V
de Souza
H B
HB
Braz
L M
LM
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D051379:Mice; D009593:Nitroimidazoles / Q000627:therapeutic use*; D013997:Time Factors; D014224:Triatoma / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects
D009593:Nitroimidazoles; C009999:benzonidazole
Novo processo para triagem de medicamentos na infecção experimental pelo Trypanosoma cruzi.