A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
The v-akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways.
Bellacosa
A
A
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111.
Testa
J R
JR
Staal
S P
SP
Tsichlis
P N
PN
D000595:Amino Acid Sequence; D000818:Animals; D051379:Mice; D008907:Mink; D008908:Mink Cell Focus-Inducing Viruses / Q000235:genetics; D008969:Molecular Sequence Data; D051058:Oncogene Protein v-akt; D009857:Oncogenes / Q000235:genetics*; D011494:Protein Kinases / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D015682:Retroviridae Proteins, Oncogenic; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases; D051058:Oncogene Protein v-akt; D017346:Protein Serine-Threonine Kinases