title: A product of mevalonate proximal to isoprenoids is the source of both a necessary growth factor and an inhibitor of cell proliferation.
abstract: These studies demonstrate that mevalonate or the mevalonate phosphates play a number of regulatory roles in cellular proliferation. They are not only required for cell growth but are also a source of an inhibitor of cell growth. Endogenous concentrations of mevalonate and the mevalonate phosphates are thus critical determinants of cellular proliferation.
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.
authors.forename: J A
authors.initials: JA
authors.lastname: Cuthbert
authors.forename: P E
authors.initials: PE
authors.lastname: Lipsky
mesh_terms: D002455:Cell Division / Q000502:physiology*; D006131:Growth Inhibitors / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008798:Mevalonic Acid / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism
chemical_list: D006131:Growth Inhibitors; D006133:Growth Substances; D011506:Proteins; D008798:Mevalonic Acid