Atlantoaxial subluxation in a patient with mixed connective tissue disease.
We describe a 55-year-old woman with an 8-year history of mixed connective tissue disease (MCTD). Her condition was characterized by severe Raynaud's, swollen fingers, digital ulceration and gangrene, esophagitis, polyarthropathy, myositis and restrictive lung function. She consistently had antibodies to U1-RNP. Rheumatoid factor was present in low titer. She developed atlantoaxial subluxation, a feature seen commonly in rheumatoid arthritis, reported in spondyloarthropathy and a small number of patients with systemic lupus erythematosus but not described in MCTD.
Stuart
R A
RA
Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath, England.
Maddison
P J
PJ
D000906:Antibodies / Q000032:analysis / Q000276:immunology; D001268:Atlanto-Axial Joint / Q000000981:diagnostic imaging / Q000293:injuries*; D005260:Female; D005734:Gangrene / Q000150:complications; D006801:Humans; D004204:Joint Dislocations / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008168:Lung / Q000473:pathology / Q000502:physiology; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000276:immunology / Q000473:pathology; D009220:Myositis / Q000150:complications; D011859:Radiography; D011928:Raynaud Disease / Q000150:complications; D012217:Rheumatoid Factor / Q000032:analysis; D012261:Ribonucleoproteins / Q000276:immunology; D017411:Ribonucleoproteins, Small Nuclear
D000906:Antibodies; D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear; D012217:Rheumatoid Factor