Efficient DNA pairing in a Neurospora mutant defective in chromosome pairing.
A Neurospora crassa mutation, mei-2, affecting recombination and pairing of homologous chromosomes during meiosis, was characterized for its effect on repeat-induced point mutation (RIP). We found that RIP, which depends on recognition of DNA sequence homology, is not inhibited by mei-2, suggesting that the defect in chromosome pairing of this mutant is not due to a defect in DNA pairing and that DNA pairing is not dependent on chromosome pairing.
Foss
H M
HM
Institute of Molecular Biology, University of Oregon, Eugene 97403.
Selker
E U
EU
D000667:Ampicillin / Q000494:pharmacology; D015825:Chromosomes, Fungal / Q000378:metabolism*; D003433:Crosses, Genetic; D004271:DNA, Fungal / Q000378:metabolism*; D004352:Drug Resistance, Microbial / Q000235:genetics; D005800:Genes, Fungal / Q000235:genetics; D009154:Mutation / Q000235:genetics; D009492:Neurospora crassa / Q000187:drug effects / Q000235:genetics*; D011995:Recombination, Genetic / Q000235:genetics*
D004271:DNA, Fungal; D000667:Ampicillin