Synthesis of some oligodeoxynucleotides containing the C-nucleoside and 2'-deoxy-2'-fluoronucleoside moieties.
An automated computer-controlled, multipurpose synthesizer, featuring a novel method for the transport of liquids, was constructed and used in the synthesis of oligomers containing some C-nucleoside and 2'-deoxy-2'-fluoronucleoside moieties by the H-phosphonate procedure. The synthetic method and some prospects for biological use are outlined.
Rosenberg
I
I
Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division of Graduate School of Medical Sciences, Cornell University, New York, NY 10021.
Tocik
Z
Z
Watanabe
K A
KA
D001483:Base Sequence; D003201:Computers; D005461:Fluorine; D007202:Indicators and Reagents; D008969:Molecular Sequence Data; D009705:Nucleosides; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D009705:Nucleosides; D009838:Oligodeoxyribonucleotides; D005461:Fluorine