title: Absorbed dose estimates in positron emission tomography studies based on the administration of 18F-labeled radiopharmaceuticals.
abstract: Absorbed doses were estimated after intravenous administration of 18F-labeled radiopharmaceuticals in Positron Emission Tomography (PET) studies. These radiopharmaceuticals, [18F]-2-Fluoro-2-Deoxy-D-Glucose (FDG), 6-[18F]Fluoro-L-Dopa (FDOPA) and 18F-5-Fluorodeoxyuridine (FdUR), are used in clinical research at the Cyclotron and Radioisotope Center of Tohoku University. Radiopharmaceutical biokinetic values were measured in humans or extrapolated from animal experiments. Selective organ uptake and rapid clearance of activity from the blood were observed. High activity in the bladder contents of humans was found. Calculations were made by the MIRD method, modified to account for the differences in physique and organ mass between the Caucasian Reference Man and the Japanese one. The bladder wall receives the highest dose (more than 1.23 x 10(-1) mGy/MBq) when any of these compounds are administered. Other organs receiving high doses are the heart, brain and kidneys from FDG; the kidneys and pancreas from FDOPA, and the kidneys and small intestine from FdUR. These organs received absorbed doses of more than 2.7 x 10(-2) mGy/MBq. Effective dose equivalents of 2.4 x 10(-2), 2.6 x 10(-2) and 3.3 x 10(-2) mSv/MBq were estimated in the intravenous administration of 18F-FDG, 18F-FDOPA and 18F-FdUR, respectively.
authors.affiliation: Division of Radiation Protection, Tohoku University, Sendai, Japan.
authors.forename: A A
authors.initials: AA
authors.lastname: Mejia
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: J
authors.initials: J
authors.lastname: Hatazawa
authors.forename: K
authors.initials: K
authors.lastname: Ishiwata
authors.forename: T
authors.initials: T
authors.lastname: Ido
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Watabe
authors.forename: S
authors.initials: S
authors.lastname: Watanuki
authors.forename: S
authors.initials: S
authors.lastname: Seo
mesh_terms: D000328:Adult; D000818:Animals; D003847:Deoxyglucose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004295:Dihydroxyphenylalanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004285:Dogs; D005467:Floxuridine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007275:Injections, Intravenous; D051379:Mice; D008875:Middle Aged; D011829:Radiation Dosage; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005462:Fluorine Radioisotopes; D005467:Floxuridine; D019788:Fluorodeoxyglucose F18; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D003847:Deoxyglucose