Low frequency maintenance ganciclovir for cytomegalovirus retinitis.
45 patients on maintenance ganciclovir for treated cytomegalovirus (CMV) retinitis were reviewed retrospectively. Treatment was given at 30 mg/kg/week in 3 divided doses: Monday, Wednesday, Friday. The median time to clinical relapse was 5.4 months. This is similar to that reported with higher frequency maintenance regimens. The high degree of immunodeficiency (median CD4 count 16 cells/microliters) and poor prognosis (median survival 8.2 months) associated with CMV retinitis were confirmed.
Hall
A J
AJ
University of Melbourne, Department of Ophthalmology, Victoria, Australia.
Jennens
I D
ID
Lucas
C R
CR
MacLean
H
H
Sandland
A M
AM
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000368:Aged; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy*; D015828:Eye Infections, Viral / Q000150:complications / Q000188:drug therapy*; D015774:Ganciclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications / Q000188:drug therapy; D011379:Prognosis; D012008:Recurrence; D012173:Retinitis / Q000150:complications / Q000188:drug therapy*; D012189:Retrospective Studies
D015774:Ganciclovir