title: Pseudorabies virus-induced suppression of major histocompatibility complex class I antigen expression.
abstract: The ability of pseudorabies virus (PrV) to down-modulate expression of major histocompatibility complex class I antigens in murine and porcine cells was investigated. When quantified by flow cytometry, surface expression of class I Kk and Dk antigens on PrV-infected cells decreased by 60% or more. Down-modulation was associated with a decrease in total cellular class I antigens, indicating regulation at the transcriptional or posttranscriptional level. PrV did not suppress expression of transferrin receptor, suggesting a selective regulatory mechanism.
authors.affiliation: Department of Microbiology, Miami University, Oxford, Ohio 45056.
authors.forename: M W
authors.initials: MW
authors.lastname: Mellencamp
authors.forename: P C
authors.initials: PC
authors.lastname: O'Brien
authors.forename: J R
authors.initials: JR
authors.lastname: Stevenson
mesh_terms: D000818:Animals; D015536:Down-Regulation; D011558:Herpesvirus 1, Suid / Q000235:genetics / Q000502:physiology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D007108:Immune Tolerance; D011818:Rabies / Q000276:immunology; D011990:Receptors, Transferrin / Q000276:immunology; D014158:Transcription, Genetic
chemical_list: D015395:Histocompatibility Antigens Class I; D011990:Receptors, Transferrin