title: Synthesis of nucleosides as potential inhibitors of purine biosynthesis.
abstract: The synthesis of analogues of 4-carboxy-5-amino-1-beta-D-ribofuranosylimidazole-5'-phosphate (CAIR) in which the carbonyl group is replaced by a grouping of tetrahedral geometry is described. These are planned as transition state inhibitors of SAICAR synthetase, the enzyme which converts CAIR into its amide with L-aspartic acid.
authors.affiliation: Department of Chemistry, Heriot-Watt University, Riccarton, Edinburgh, UK.
authors.forename: J G
authors.initials: JG
authors.lastname: Buchanan
authors.forename: R H
authors.initials: RH
authors.lastname: Wightman
mesh_terms: D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010453:Peptide Synthases / Q000037:antagonists & inhibitors; D011687:Purines / Q000737:chemistry*; D012265:Ribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011687:Purines; D012265:Ribonucleotides; D000620:Aminoimidazole Carboxamide; D010453:Peptide Synthases; C022379:phosphoribosylaminoimidazole-succinocarboxamide synthetase; C031143:AICA ribonucleotide