[Promotive effects of thymus peptide on mitogen-induced child thymocyte proliferation].
This paper reports a cytocentrifugation study of the morphological changes of mitogen-induced proliferating child thymocytes stimulated by thymus peptides. The proliferation response of child thymocytes to PHA was far more significant than those to ConA and PWN. This differs from the more pronounced effect of ConA on thymocyte proliferation in mice. In vitro, child thymocytes did not respond to thymus peptide without mitogen-induction. However, when thymus peptide was added to thymocyte culture with PHA, ConA, or PWN, proliferation responses were significantly enhanced, being most marked in the PHA-induced cell culture. The mechanism of the enhancing effect of thymus peptide on mitogen-induced human thymocytes is discussed.
Chen
Y
Y
Capital Institute of Pediatrics, Beijing.
Hosking
C S
CS
D004357:Drug Synergism; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D008213:Lymphocyte Activation; D008934:Mitogens / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology
D008934:Mitogens; D010455:Peptides