Vincristine-induced peripheral neuropathy in a dog.
A 12-year-old spayed Golden Retriever with mycosis fungoides was treated by use of a chemotherapy protocol that included vincristine. After 16 weekly vincristine injections, the dog began to have signs of peripheral neuropathy. Results of electromyographic examination were consistent with muscle denervation, and motor nerve conduction velocity was depressed. Histologic examination of a common peroneal nerve biopsy specimen revealed severe nerve fiber degeneration. Clinical response and pathologic evidence of improvement were observed after the drug had been discontinued for 2.5 months.
Hamilton
T A
TA
Department of Veterinary Clinical Sciences College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
Cook
J R
JR
Braund
K G
KG
Morrison
W B
WB
Mehta
J R
JR
D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D004576:Electromyography / Q000662:veterinary; D005260:Female; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000662:veterinary*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000662:veterinary*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use
D014750:Vincristine