Swerchirin induced blood sugar lowering of streptozotocin treated hyperglycemic rats.
Effect of Swerchirin (1:8 dihydroxy 3:5 dimethoxy xanthone) isolated from hexane fraction of Swertia chirayita on the blood sugar level of healthy and streptozotocin treated rats was studied. Streptozotocin was administered in citrate buffer (pH-4.5) intravenously / 35 and 65 mg/kg body wt to Charles Foster strain albino rats. Swerchirin (50 mg/kg, po) suspended in gum acacia was fed through cannula to the above rats and to a group of healthy rats. Blood sugar estimated at 0, 1, 3 and 7 hr after, indicated a very significant lowering in healthy and streptozotocin (35 mg/kg iv) but not in streptozotocin (65 mg/kg) treated rats.
Saxena
A M
AM
Central Drug Research Institute, Lucknow, India.
Bajpai
M B
MB
Mukherjee
S K
SK
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D013311:Streptozocin; D014966:Xanthenes / Q000494:pharmacology* / Q000627:therapeutic use; D044004:Xanthones
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D014966:Xanthenes; D044004:Xanthones; C034385:swerchirin; D013311:Streptozocin