title: Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence.
abstract: Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.
authors.affiliation: Department of Physiology, University of California, San Francisco.
authors.forename: D M
authors.initials: DM
authors.lastname: Papazian
authors.forename: L C
authors.initials: LC
authors.lastname: Timpe
authors.forename: Y N
authors.initials: YN
authors.lastname: Jan
authors.forename: L Y
authors.initials: LY
authors.lastname: Jan
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000737:chemistry; D003001:Cloning, Molecular; D004331:Drosophila melanogaster / Q000235:genetics*; D004553:Electric Conductivity; D004563:Electrochemistry; D004594:Electrophysiology; D015640:Ion Channel Gating / Q000502:physiology; D016297:Mutagenesis, Site-Directed; D009865:Oocytes / Q000378:metabolism; D015221:Potassium Channels / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid; D015222:Sodium Channels / Q000737:chemistry; D013329:Structure-Activity Relationship; D014162:Transfection; D014981:Xenopus
chemical_list: D015220:Calcium Channels; D015221:Potassium Channels; D015222:Sodium Channels