title: Fatal overdose of amphotericin B in two preterm infants.
abstract: Two premature infants exhibited an acute cardiorespiratory collapse shortly after receiving a 50-fold overdose of amphotericin B (AmB). Despite aggressive intervention both infants died. Serum AmB levels were double the normal therapeutic range. We speculate that two less well-recognized toxic complications of AmB involving the cardiac and respiratory systems may have contributed to the fatal outcome.
authors.affiliation: Department of Pediatrics, UT Southwestern Medical Center, Dallas.
authors.forename: J M
authors.initials: JM
authors.lastname: Perlman
authors.forename: M
authors.initials: M
authors.lastname: Acarregui
authors.forename: J W
authors.initials: JW
authors.lastname: Gard
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male
chemical_list: D000666:Amphotericin B