title: Neonatal lupus erythematosus with multisystem organ involvement preceding cutaneous lesions.
abstract: Here we report a case of neonatal lupus erythematosus syndrome presenting with multisystem organ involvement, including anemia, thrombocytopenia, purpura, bloody diarrhea, enzymatic liver abnormalities, splenomegaly and pneumonitis. These findings preceded the cutaneous rash that was the clue for the diagnosis. The patient's mother had an undiagnosed subacute cutaneous lupus erythematosus. The various forms of onset of neonatal lupus erythematosus syndrome are emphasized.
authors.affiliation: Department of Dermatology, Hospital La Paz, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Fonseca
authors.forename: F
authors.initials: F
authors.lastname: Contreras
authors.forename: E
authors.initials: E
authors.lastname: García-Frías
authors.forename: M C
authors.initials: MC
authors.lastname: Carrascosa
mesh_terms: D000328:Adult; D001324:Autoantigens / Q000032:analysis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000276:immunology / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology / Q000473:pathology*; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins / Q000032:analysis; D012871:Skin Diseases / Q000150:complications / Q000473:pathology*; D000097585:SS-B Antigen; D000099207:SS-A Antigen
chemical_list: D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen; C116006:RO60 protein, human