title: (S)-UH-301 antagonizes (R)-8-OH-DPAT-induced cardiovascular effects in the rat.
abstract: The 5-HT1A-receptor antagonist (S)-UH-301 (S)-5-fluoro-8-hydroxy-2- (dipropylamino)tetralin) completely antagonized the hypotension and bradycardia induced by (R) = 8-OH DPAT [R)-8-hydroxy-2- (dipropylamino)tetralin) in conscious rats. (S)-UH-301 alone induced a weak hypertension, which might be due to its 5-HT1A-receptor antagonistic properties. (R)-UH-301 induced effects similar to those of (R)-8-OH DPAT, i.e., a short initial phase of hypertension followed by a long-lasting hypotension and bradycardia. Thus, (R)-UH-301 behaves as a 5-HT1A-receptor agonist and (S)-UH-301 as a 5-HT1A-receptor antagonist, abolishing the effects induced by (R)-8-OH DPAT.
authors.affiliation: Department of Medical Pharmacology, Uppsala University, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Björk
authors.forename: S
authors.initials: S
authors.lastname: Lindgren
authors.forename: U
authors.initials: U
authors.lastname: Hacksell
authors.forename: T
authors.initials: T
authors.lastname: Lewander
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000031:analogs & derivatives; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects*; D003243:Consciousness; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology; D013237:Stereoisomerism; D013764:Tetrahydronaphthalenes / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D012702:Serotonin Antagonists; D013764:Tetrahydronaphthalenes; C064282:UH 301; D012965:Sodium Chloride; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin