title: [Influence of protein S deficiency on the arterial thrombosis risk].
abstract: Protein S is the cofactor of activated protein C which, together with the antithrombin system, is a major regulator of coagulation. Congenital protein S deficiency is an important risk factor for venous thrombosis. In this study of 105 patients with protein S deficiency, 64 had one of several thromboembolic accidents, including 14 arterial thrombotic accidents involving the central nervous system or the myocardium. These accidents occurred in young subjects (mean age: 25 +/- 13 years) only one-third of whom had another risk factor. This high frequency of arterial thrombosis associated with protein S deficiency calls for a prospective study in young subject with cerebral vascular accident or myocardial infarction.
authors.affiliation: Service d'Hémostase et de Thrombose, INSERM U311, CRTS, Strasbourg.
authors.forename: M L
authors.initials: ML
authors.lastname: Wiesel
authors.forename: J Y
authors.initials: JY
authors.lastname: Borg
authors.forename: L
authors.initials: L
authors.lastname: Grunebaum
authors.forename: M
authors.initials: M
authors.lastname: Vasse
authors.forename: H
authors.initials: H
authors.lastname: Levesque
authors.forename: R
authors.initials: R
authors.lastname: Bierme
authors.forename: P
authors.initials: P
authors.lastname: Sie
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006023:Glycoproteins / Q000172:deficiency*; D006801:Humans; D007122:Immunoelectrophoresis; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D017293:Protein S; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology*
chemical_list: D006023:Glycoproteins; D017293:Protein S
vernacular_title: Influence du déficit constitutionnel en protéine S sur le risque thrombotique artériel.