Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations.
Chromosomal region 11q23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from 11q23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;11), t(9;11), and t(11;19) translocations. The breakpoints cluster in a small DNA region of less than 5.8 kilobases.
Cimino
G
G
Jefferson Cancer Institute, Jefferson Cancer Center, Philadelphia, Pennsylvania.
Moir
D T
DT
Canaani
O
O
Williams
K
K
Crist
W M
WM
Katzav
S
S
Cannizzaro
L
L
Lange
B
B
Nowell
P C
PC
Croce
C M
CM
D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D015152:Blotting, Northern; D015139:Blotting, Southern; D017252:CD3 Complex; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D002894:Chromosomes, Human, Pair 4; D002899:Chromosomes, Human, Pair 9; D003001:Cloning, Molecular; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D015183:Restriction Mapping; D014178:Translocation, Genetic / Q000235:genetics*
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D004273:DNA, Neoplasm; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D011948:Receptors, Antigen, T-Cell