title: A comparison of tocopherol and tocotrienol for the chemoprevention of chemically induced rat mammary tumors.
abstract: Two forms of vitamin E, tocopherol and tocotrienol, were tested for chemopreventive activity in two chemically induced rat mammary-tumor models. When mammary tumors were induced by 7,12-dimethylbenz(a)anthracene (DMBA, 50 mg/kg), only the tocotrienol group had a statistically significant increase in tumor latency. There was no effect of either compound on tumor multiplicity. When tumors were induced by N-nitrosomethylurea (NMU, 30 mg/kg), neither analogue of vitamin E modified latency, whereas tocotrienol increased tumor multiplicity. In summary, neither vitamin analog had a major impact on mammary-tumor development after tumor induction with either DMBA or NMU.
authors.affiliation: Department of Human Oncology, University of Wisconsin-Madison 53792.
authors.forename: M N
authors.initials: MN
authors.lastname: Gould
authors.forename: J D
authors.initials: JD
authors.lastname: Haag
authors.forename: W S
authors.initials: WS
authors.lastname: Kennan
authors.forename: M A
authors.initials: MA
authors.lastname: Tanner
authors.forename: C E
authors.initials: CE
authors.lastname: Elson
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control*; D008770:Methylnitrosourea; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D015127:9,10-Dimethyl-1,2-benzanthracene; D008770:Methylnitrosourea