[Study of diabetogenic and lympholytic effects during single and fractional administration of streptozotocin to mice of the mutant strain C57BL/KsIY-db/m].
Single administration of streptozotocin at a dose of 200 mg/kg into mice males of the C57BL/KsJY db/m strain induced severe form of insulin-dependent diabetes within the earlier periods as compared with fractional injection of the drug (40 mg/kg daily within 5 days). Streptozotocin-induced diabetes, developed after single administration of the drug, caused pronounced destructions in lymphoid tissue, primarily in thymus as content of DNA was drastically decreased in the tissue and level of DNA breakdown products was increased. The lympholytic effect of streptozotocin was less distinct after fractional administration.
Blokh
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Poltorak
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D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004247:DNA / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006579:Heterozygote; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008817:Mice, Mutant Strains; D013311:Streptozocin / Q000008:administration & dosage / Q000633:toxicity*
D001786:Blood Glucose; D013311:Streptozocin; D004247:DNA
Issledovanie diabetogennykh i limfoliticheskikh éffektov pri odnokratnom i drobnom vvedenii streptozototsina mysham mutantnoĭ linii C57BL/KsIY-db/m.