Evidence for tau expression in cells of monocyte lineage and its in vitro phosphorylation by v-fms kinase.
The v-fms encoded kinase, which is known to associate with cytoskeletal elements, was shown to phosphorylate histiocytic proteins that had physical and immunological attributes in common with tau. Tau is a microtubule associated protein that is aberrantly phosphorylated in Alzheimer's disease of the brain. Since c-fms expression is normally exclusive to cells of monocyte lineage, these cells were examined for expression of tau. Heat stable tau was identified in cultured peripheral blood monocytes. This represents the first molecular characterization of tau in cells of non-neural origin.
Kim
H
H
Department of Cell Biology University of Alabama, Birmingham.
Strong
T V
TV
Anderson
S J
SJ
D002460:Cell Line; D015870:Gene Expression; D016236:Genes, fms / Q000502:physiology; D006801:Humans; D015151:Immunoblotting; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D009000:Monocytes / Q000378:metabolism*; D010766:Phosphorylation; D011233:Precipitin Tests; D011494:Protein Kinases / Q000235:genetics*; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000502:physiology*; D016875:tau Proteins
D008869:Microtubule-Associated Proteins; D016875:tau Proteins; D011494:Protein Kinases; D016186:Receptor, Macrophage Colony-Stimulating Factor