Effect of high-fat and low-fiber meals on the cell proliferation activity of colorectal mucosa.
Normal healthy volunteers (n = 43) were divided into four groups that received diets providing low or high levels of dietary fat (33 or 96 g/day) and low or high levels of dietary fiber (6 and 41 g/day) for a period of five days. Proliferation was assessed with tritiated thymidine labeling of three rectal biopsies. After five days on the prescribed diets, the average thymidine labeling index (LI) of the group on the high fat-low fiber diet was only 25% higher than the average LI of the group on the low fat-high fiber diet, a difference that is not statistically significant. We conclude that a short-term increase in dietary fat and decrease in dietary fiber does not result in a large increase in cell proliferation rate.
Gregoire
R
R
Department of Surgery, University of Toronto, Ontario, Canada.
Yeung
K S
KS
Stadler
J
J
Stern
H S
HS
Kashtan
H
H
Neil
G
G
Bruce
W R
WR
D000328:Adult; D000704:Analysis of Variance; D001647:Bile Acids and Salts / Q000378:metabolism; D002455:Cell Division; D003106:Colon / Q000166:cytology*; D004041:Dietary Fats / Q000494:pharmacology*; D004043:Dietary Fiber / Q000494:pharmacology*; D005243:Feces; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000166:cytology; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012007:Rectum / Q000166:cytology*; D013997:Time Factors
D001647:Bile Acids and Salts; D004041:Dietary Fats; D004043:Dietary Fiber