The Wisconsin age-related maculopathy grading system.
A new system for grading age-related maculopathy is described and measures of reliability are reported. A number of characteristics of age-related maculopathy are graded in a semiquantitative fashion from stereoscopic 30 degrees color fundus photographs, using a grid to define subfields, standard circles printed on plastic to assess size and area, and a specially designed lightbox to allow better discrimination of subtle drusen. The degree of exact agreement achieved between two trained graders across a variety of lesions ranged from 67.1% for drusen size to 99.6% for geographic atrophy. Kappa scores ranged from 0.55 (for drusen confluence) to 0.95 for geographic atrophy. This system will be useful in epidemiologic studies and clinical trials.
Klein
R
R
Department of Ophthalmology, University of Wisconsin Medical School, Madison.
Davis
M D
MD
Magli
Y L
YL
Segal
P
P
Klein
B E
BE
Hubbard
L
L
D000375:Aging / Q000473:pathology; D005654:Fundus Oculi; D006801:Humans; D008268:Macular Degeneration / Q000145:classification / Q000473:pathology*; D010781:Photography; D015203:Reproducibility of Results; D015593:Retinal Drusen / Q000473:pathology; D014922:Wisconsin