Protein I of N. gonorrhoeae shows that phosphatidate from phosphatidylcholine via phospholipase C is an intracellular messenger in neutrophil activation by chemoattractants.
Haines
K A
KA
New York University School of Medicine, Dept. of Pediatrics, New York 10016.
Weissmann
G
G
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D004075:Diglycerides / Q000032:analysis / Q000096:biosynthesis; D006801:Humans; D007975:Leukotriene B4 / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D009344:Neisseria gonorrhoeae / Q000032:analysis*; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010712:Phosphatidic Acids / Q000096:biosynthesis / Q000502:physiology*; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000032:analysis; D018272:Porins; D011961:Receptors, Fc / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology*; D010738:Type C Phospholipases / Q000378:metabolism
D001425:Bacterial Outer Membrane Proteins; D004075:Diglycerides; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D010743:Phospholipids; D018272:Porins; D011961:Receptors, Fc; D007975:Leukotriene B4; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D009240:N-Formylmethionine Leucyl-Phenylalanine; D010738:Type C Phospholipases; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid