title: [Evaluation of the use of thymopentin in patients with progressive systemic sclerosis].
abstract: Although the exact etiology of progressive systemic sclerosis (SSP) is still unknown, it is felt that immunologic disorders may be implicated in its pathogenesis. On the basis of these considerations, an open study with an immunomodulating drug, thymopentin, was performed in 20 SSP outpatients. These subjects were initially treated with thymopentin three times a week for three consecutive months (phase I); during a second study phase lasting three months, 10 patients continued to receive thymopentin and the remaining 10 placebo (phase II). A significant improvement in various clinical, laboratory and instrumental findings was seen following thymopentin treatment. During phase II, those on placebo regressed to basal conditions, while an added improvement was noted in those who continued with thymopentin.
authors.affiliation: Istituto di Reumatologia, Istituto degli Studi di Siena.
authors.forename: N
authors.initials: N
authors.lastname: Giordano
authors.forename: G
authors.initials: G
authors.lastname: Biasi
authors.forename: D
authors.initials: D
authors.lastname: Vaccai
authors.forename: G
authors.initials: G
authors.lastname: Morozzi
authors.forename: R
authors.initials: R
authors.lastname: Marcolongo
authors.forename: D
authors.initials: D
authors.lastname: Bertelletti
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000188:drug therapy*; D016305:Thymopentin / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D016305:Thymopentin
vernacular_title: Valutazione dell'impiego di timopentina in pazienti affetti da sclerosi sistemica progressiva.