Synthesis and its properties of oligonucleotide analogue containing thiocarbamate interlinkages.
Novel nucleotide analogues have been synthesized from morpholine subunits with thiocarbamate linkages. They indicated much stronger interaction with poly U or poly dT than the corresponding natural oligodeoxyribonucleotides. Solubility of the analogues in water was greatly enhanced by introducing sulfate groups at their both ends.
Ohgi
T
T
Research Laboratories, Nippon Shinyaku Co. Ltd, Kyoto, Japan.
Ishiyama
K
K
Tomi
H
H
Yano
J
J
D015394:Molecular Structure; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature; D013859:Thiocarbamates / Q000737:chemistry*
D009841:Oligonucleotides; D013859:Thiocarbamates