title: Combined activity of trospectomycin and colloidal bismuth subcitrate against Helicobacter pylori in vitro.
abstract: The combined activities of trospectomycin, a spectinomycin analogue, and colloidal bismuth subcitrate against Helicobacter pylori were investigated, the agar dilution method being employed. Forty-seven strains of H. pylori were examined. An additive effect was observed in 89%, and a synergistic interaction in 11% of the isolates. There was no antagonism observed. The MIC50 of trospectomycin against H. pylori was 2 mg/l; the MIC ranged from 0.5 to 4 mg/l.
authors.affiliation: Institut für Medizinische Mikrobiologie, Freie Universität Berlin.
authors.forename: K
authors.initials: K
authors.lastname: Vogt
authors.forename: A C
authors.initials: AC
authors.lastname: Rodloff
authors.forename: H
authors.initials: H
authors.lastname: Hahn
mesh_terms: D000863:Antacids / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D016480:Helicobacter pylori / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000494:pharmacology*; D000198:Spectinomycin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000863:Antacids; D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; C043267:trospectomycin; D000198:Spectinomycin; C002791:bismuth tripotassium dicitrate