title: [Ovarian carcinomas. Intraperitoneal chemotherapy by needle].
abstract: Between January 1980 and February 1988, 61 women with ordinary ovarian carcinoma (OC) were treated with combined intraperitoneal and intravenous first-line therapy. For intraperitoneal infusions we did not use implanted systems which are often poorly tolerated and sometimes create non-negligible complications. We simply used a lumbar puncture needle left in situ for less than 2 hours. In second regard laparotomies, the 7 patients with stage I OC and the 3 patients with stage II OC were in histologically and cytologically proven complete remission, as were 34 of the 43 patients with stage III OC (79 percent) and 1 of the 8 patients with stage IV OC. After a mean follow-up of 56 months, the overall actuarial survival rate was 66 percent and the survival rate without recurrence was 54 percent. During the same period, 26 patients with recurrent OC were treated with second-line intraperitoneal chemotherapy. After a mean follow-up of 30 months, 10 were in apparently complete remission, and after a 27 to 61 months period 7 of these 10 patients had no recurrence. These results must be compared with those obtained with other salvage methods.
authors.affiliation: Hôpital Bichat, Paris.
authors.forename: B
authors.initials: B
authors.lastname: Zylberberg
authors.forename: D
authors.initials: D
authors.lastname: Dormont
authors.forename: J H
authors.initials: JH
authors.lastname: Ravina
authors.forename: P
authors.initials: P
authors.lastname: Madelenat
authors.forename: J
authors.initials: J
authors.lastname: Salat-Baroux
authors.forename: G
authors.initials: G
authors.lastname: Ferrand
authors.forename: J M
authors.initials: JM
authors.lastname: Antoine
authors.forename: G
authors.initials: G
authors.lastname: Pennehouat
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced; D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007274:Injections, Intraperitoneal; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D011182:Postoperative Care; D012074:Remission Induction; D014840:Vomiting, Anticipatory / Q000209:etiology
vernacular_title: Carcinomes ovariens. Chimiothérapie intrapéritonéale à l'aiguille.