Myocardial collagen degradation: morphological and biochemical correlation.
An attempt was made to prove the phenomenon of myocardial collagen breakdown in a norepinephrine (NE) induced model of reversible cardiopathy in anesthetized rabbits. NE (0.3 mg/kg in 90 min) was infused to 22 animals. Histologically it was found that immediately and during the first two days after the catecholamine administration the myocardial collagenous network became disrupted and it partly disappeared. Collagenase and peptidase activities were measured from homogenates of the same hearts. A significant increase of these activities was observed and that could be correlated with the intracellular matrix destruction.
Illyés
G
G
Department of Morphology, National Institute of Physiotherapy, Budapest, Hungary.
Hamar
J
J
Tanka
D
D
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D017364:Collagenases / Q000378:metabolism; D004195:Disease Models, Animal; D010450:Endopeptidases / Q000378:metabolism; D005109:Extracellular Matrix / Q000473:pathology; D005260:Female; D006352:Heart Ventricles / Q000378:metabolism; D008297:Male; D009638:Norepinephrine; D011817:Rabbits
D003094:Collagen; D010450:Endopeptidases; D017364:Collagenases; D009638:Norepinephrine