Contact sensitivity to miconazole with ortho-chloro cross-sensitivity to other imidazoles.
A case of allergic contact dermatitis from miconazole is reported. Patch testing with a series of azole antimycotics was positive only to miconazole, isoconazole, tioconazole and oxiconazole. Those reacting are all beta-substituted 1-phenethyl imidazoles with an ortho-chlorine substitution on the aromatic ring. For this hitherto unreported pattern of cross-sensitivity, the designation of "ortho-chloro cross-sensitivity" is proposed.
Baes
H
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Department of Dermatology, H. Serruys Hospital, Ostend, Belgium.
D003877:Dermatitis, Contact / Q000209:etiology*; D003875:Drug Eruptions / Q000209:etiology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects* / Q000737:chemistry; D008825:Miconazole / Q000009:adverse effects* / Q000737:chemistry; D008875:Middle Aged
D007093:Imidazoles; D008825:Miconazole