Appearance of the T-cell marker CD8 on B chronic lymphatic leukemia cells in long-term cultures.
Long-term cultures of highly purified B chronic lymphatic leukemia cells (B-CLL), were established. The B-CLL lymphocytes acquired the CD8 T cell marker in long-term cultures while still retaining their surface immunoglobulins. In confirmation of previous results, the cultured B-CLL lymphocytes released factor(s) into the culture medium that suppressed the allogeneic mixed-lymphocyte reaction. No correlation was found between the appearance of the CD8 T cell surface marker and onset of suppressor activity.
Farkas
R
R
Laboratory for Clinical Immunology, Meir Hospital, Kfar-Saba, Israel.
Ben-Efraim
S
S
Manor
Y
Y
Zan-Bar
I
I
Klajman
A
A
D000954:Antigens, Surface / Q000276:immunology; D016827:CD8 Antigens / Q000032:analysis* / Q000276:immunology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000276:immunology* / Q000473:pathology; D007959:Lymphocyte Culture Test, Mixed; D013491:Suppressor Factors, Immunologic / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000276:immunology
D000954:Antigens, Surface; D016827:CD8 Antigens; D013491:Suppressor Factors, Immunologic