Complete remission in refractory anaplastic adult Wilms' tumor treated with cisplatin and etoposide.
A 61-year-old woman underwent a left radical nephrectomy for Stage II anaplastic Wilm's tumor. She received no adjuvant therapy. One year later computerized tomography (CT) of the abdomen revealed a mass in the left renal fossa and retroperitoneal adenopathy. A CT-guided needle biopsy was nondiagnostic. The patient had progressive disease after treatment with dactinomycin, doxorubicin, and vincristine, but achieved a complete response after treatment with cisplatin and etoposide. The therapy of Wilms' tumor in adults is discussed.
Sparano
J A
JA
Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York 10467.
Beckwith
J B
JB
Mitsudo
S
S
Wiernik
P H
PH
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009392:Nephrectomy; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D009396:Wilms Tumor / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery
D005047:Etoposide; D002945:Cisplatin