Influence of IL-6 on proliferation and differentiation of tonsillar lymphocytes and detection of IL-6 producing cells in tonsil.
When tonsillar B cells were cultured in the presence of exogenous interleukin-6 (IL-6), a small portion of them differentiated into plasma cells which seemed to have IL-6 receptors on their surfaces. The number of plasma cells tended to be greater in the tonsils of children than in the tonsils of adults. When tonsillar cells collected by Ficoll-Conray's method were cultured in medium containing IL-6, T cells differentiated and the number of activated T cells increased. Of the four subsets of T cells, this effect of IL-6 was strongest on cytotoxic T cells. IL-6-mediated proliferation and activation of cytotoxic T cells tended to be greater in the tonsils of children than in those of adults. IL-6 is produced in some tonsillar macrophages. The number of macrophages producing IL-6 was very different in different subjects. However, the number of macrophages producing IL-6 in tonsils of children tended to be greater than the number in tonsils of adults.
Sugiyama
M
M
Department of Otorhinolaryngology, Osaka Municipal Shirokita Citizen's Hospital, Japan.
Uekawa
M
M
Yamane
H
H
Takeda
M
M
Sakamoto
H
H
Nishimoto
A
A
Nakai
Y
Y
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D002648:Child; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism; D014066:Palatine Tonsil / Q000166:cytology*; D010950:Plasma Cells / Q000166:cytology; D011971:Receptors, Immunologic / Q000378:metabolism; D019947:Receptors, Interleukin-6; D016176:T-Lymphocyte Subsets / Q000166:cytology
D015850:Interleukin-6; D011971:Receptors, Immunologic; D019947:Receptors, Interleukin-6