title: The effect of lithium on haematopoiesis of patients with acute myeloid leukaemia.
abstract: In 40 patients receiving induction therapy for acute myeloid leukaemia the influence of lithium carbonate on the regeneration of haematopoiesis was investigated. It was observed that lithium treatment decreases chemotherapy-induced suppression of granulo- and megacariopoiesis. The frequency of remissions and the survival time were significantly higher for the patients receiving lithium if compared with the control group. The number of CFU-GM colonies in vitro after 14-th days of incubation was also statistically higher in the lithium treated patients.
authors.affiliation: Department of Clinical Pharmacology, Copernicus Hospital, Lódź, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Korycka
authors.forename: T
authors.initials: T
authors.lastname: Robak
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001772:Blood Cell Count; D003114:Colony-Forming Units Assay; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D003561:Cytarabine; D016651:Lithium Carbonate; D004317:Doxorubicin