title: Changes in the level of IL-2, T cell subsets and the function of T suppressor cells in patients with schistosomiasis japonica.
abstract: The level of interleukin-2 (IL-2) produced by peripheral blood mononuclear cells in vitro, T cell subsets and the function of T suppressor cells (Ts) in patients with schistosomiasis japonica were investigated. It was found that the level of IL-2 induced by schistosomal antigens was significantly high and positively related to the percentage of CD4+ cells. In the groups of chronic and advanced schistosomiasis japonica, the level of IL-2 induced by schistosomal antigens was markedly lower than that in the group of acute schistosomiasis japonica, but significantly higher than that in the group of normal controls. The IL-2 level was negatively related to the percentage of CD8+ T cells and the ratio of CD4+/CD8+. The level of IL-2 induced by PHA was greatly reduced in the group of advanced schistosomiasis japonica. The changes in the level of IL-2 and its relationship with T cell subsets and the function of Ts are also discussed.
authors.affiliation: Department of Infectious Diseases, Xiehe Hospital, Tongji Medical University, Wuhan.
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Li
authors.forename: J Z
authors.initials: JZ
authors.lastname: Dai
authors.forename: Y X
authors.initials: YX
authors.lastname: Yang
authors.forename: L L
authors.initials: LL
authors.lastname: Zeng
authors.forename: S L
authors.initials: SL
authors.lastname: Li
authors.forename: Q
authors.initials: Q
authors.lastname: Yang
authors.forename: H C
authors.initials: HC
authors.lastname: Wang
authors.forename: D D
authors.initials: DD
authors.lastname: Luo
authors.forename: X H
authors.initials: XH
authors.lastname: Wang
mesh_terms: D016516:CD4-CD8 Ratio; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D012554:Schistosomiasis japonica / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D007376:Interleukin-2