title: [Macronodule associated with bilateral adrenal hyperplasia. A rare misleading cause of primary aldosteronism (two cases)].
abstract: Aldosterone-producing adrenal adenoma and bilateral hyperplasia are the two predominant subtypes of primary aldosteronism. Their recognition is based essentially on adrenal CT scan and on measurements of plasma aldosterone and 18-hydroxycorticosterone (18-OHB) concentrations in response to postural testing. We report 2 cases of primary aldosteronism associated with a unilateral hyperplastic macronodule resembling an aldosterone-producing adenoma on CT scan. Plasma aldosterone and 18-OHB concentrations were consistent with this diagnosis in one patient. In the light of these two cases and of those previously published, the investigations needed for the etiological diagnosis of primary aldosteronism are discussed.
authors.affiliation: Service d'Endocrinologie, CHR de Bordeaux, Hôpital du Haut-Lévêque, USN, Pessac.
authors.forename: F
authors.initials: F
authors.lastname: Leprat
authors.forename: A
authors.initials: A
authors.lastname: Tabarin
authors.forename: H
authors.initials: H
authors.lastname: Dubourg
authors.forename: J L
authors.initials: JL
authors.lastname: Barat
authors.forename: D
authors.initials: D
authors.lastname: Ducassou
authors.forename: P
authors.initials: P
authors.lastname: Roger
authors.forename: M
authors.initials: M
authors.lastname: Dallocchio
authors.forename: J L
authors.initials: JL
authors.lastname: Latapie
mesh_terms: D015069:18-Hydroxycorticosterone / Q000097:blood; D000236:Adenoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D000311:Adrenal Glands / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D000450:Aldosterone / Q000097:blood; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D006965:Hyperplasia / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D011859:Radiography
chemical_list: D000450:Aldosterone; D015069:18-Hydroxycorticosterone
vernacular_title: Macronodule associé à une hyperplasie bilatérale des surrénales. Une cause rare et trompeuse d'hyperaldostéronisme primaire (2 cas).