title: Immunohistochemistry in the differential diagnosis of tumours of possible myogenic origin.
abstract: A series of 34 cases of soft tissue tumours of possible muscle origin was studied immunohistochemically using different antibodies. Tissue specimens and/or aspirates from fine needle aspiration biopsy (FNAB) were examined. The results indicate that immunohistochemistry is a valuable tool in differential diagnosis of soft tissue tumours, improving diagnostic accuracy in 83.5% of the examined cases. Desmin expression confirmed muscle differentiation of tumours in 47.6% of diagnostically difficult cases. The application of immunohistochemistry may be especially helpful in rendering the diagnosis of tumour type more precise when a needle aspirate is the only available diagnostic material.
authors.affiliation: Department of Oncology, School of Medicine, Lódź.
authors.forename: A
authors.initials: A
authors.lastname: Szadowska
authors.forename: J
authors.initials: J
authors.lastname: Lasota
authors.forename: B
authors.initials: B
authors.lastname: Mirecka
authors.forename: I
authors.initials: I
authors.lastname: Giryn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003893:Desmin / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D007223:Infant; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D003893:Desmin; D014746:Vimentin