title: CD4 to CD8 ratio and in vitro lymphoproliferative responses during experimental gingivitis in pregnancy and post-partum.
abstract: The absolute numbers and percentages of peripheral T, B, and NK cells were assessed in 7 women, both during the second trimester of pregnancy and 6 months post-partum. Furthermore, the in vitro responses of peripheral blood lymphocytes (PBL) to several mitogens and a preparation of Prevotella intermedia were compared in a period of experimentally-induced gingivitis during pregnancy and post-partum. Clinically, the periodontal pocket bleeding index (PPBI) was found to be higher during pregnancy than post-partum. The absolute numbers of CD3, CD4, and CD19 positive cells appeared to be decreased during pregnancy as compared to post-partum. However, the results did not indicate any evidence for a reduced in vitro PBL response to several mitogens and a preparation of P. intermedia during pregnancy.
authors.affiliation: Department of General Pathology and Internal Medicine, Academic Center for Dentistry Amsterdam, The Netherlands.
authors.forename: J E
authors.initials: JE
authors.lastname: Raber-Durlacher
authors.forename: W P
authors.initials: WP
authors.lastname: Zeijlemaker
authors.forename: A A
authors.initials: AA
authors.lastname: Meinesz
authors.forename: L
authors.initials: L
authors.lastname: Abraham-Inpijn
mesh_terms: D000328:Adult; D000942:Antigens, Bacterial; D001402:B-Lymphocytes / Q000473:pathology; D001439:Bacteroides / Q000276:immunology; D016516:CD4-CD8 Ratio; D003774:Dental Plaque Index; D005260:Female; D005884:Gingival Hemorrhage / Q000473:pathology; D005891:Gingivitis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008934:Mitogens; D010512:Periodontal Index; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology* / Q000473:pathology; D011262:Pregnancy Trimester, Second; D011644:Puerperal Disorders / Q000276:immunology* / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology
chemical_list: D000942:Antigens, Bacterial; D008934:Mitogens