Synthesis and radiation dosimetry of 4-borono-2-[18F]fluoro-D,L-phenylalanine: a target compound for PET and boron neutron capture therapy.
The 18F-labeling of 4-borono-D-L-phenylalanine (BPA), a potential target compound for cancer treatment with boron neutron capture therapy, is described. By direct fluorination of BPA with [18F]AcOF or [18F]F2 followed by HPLC separation, 4-borono-2-[18F]fluoro-D,L-phenylalanine was prepared with radiochemical yields of 25-35% and with a radiochemical purity of over 99%. The tissue distribution study showed that the compound has potential as a tracer for pancreas imaging with positron emission tomography. Radiation dosimetry is also described.
Ishiwata
K
K
Division of Radiopharmaceutical Chemistry, Tohoku University, Sendai, Japan.
Ido
T
T
Mejia
A A
AA
Ichihashi
M
M
Mishima
Y
Y
D000818:Animals; D001896:Boron Compounds / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005462:Fluorine Radioisotopes; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D051379:Mice; D009502:Neutrons; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011874:Radiometry; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D001896:Boron Compounds; D005462:Fluorine Radioisotopes; D011838:Radiation-Sensitizing Agents; D010649:Phenylalanine; C033685:4-boronophenylalanine