Molecular cloning and characterization of the rat NMDA receptor.
A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.
Moriyoshi
K
K
Institute for Immunology, Kyoto University Faculty of Medicine, Japan.
Masu
M
M
Ishii
T
T
Shigemoto
R
R
Mizuno
N
N
Nakanishi
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D003001:Cloning, Molecular; D004594:Electrophysiology; D007051:Ibotenic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D007608:Kainic Acid / Q000737:chemistry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*; D014981:Xenopus / Q000235:genetics; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D007051:Ibotenic Acid; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D007608:Kainic Acid