Epidermodysplasia verruciformis-associated papillomavirus infection complicating human immunodeficiency virus disease.
Three males infected with the human immunodeficiency virus (HIV) were noted to have extensive flat warts of the face and/or body. In two there were also pityriasis versicolor-like lesions. Biopsies showed foamy, basophilic, distended cytoplasm in granular layer keratinocytes, characteristic of the human papillomavirus types seen in epidermodysplasia verruciformis. DNA hybridization techniques demonstrated the presence of HPV-type 8 in one patient and HPV 5 and 8 in another. Patients with immune suppression due to HIV infection may demonstrate the clinical features of epidermodysplasia verruciformis with the same potentially oncogenic HPV types.
Berger
T G
TG
Department of Dermatology, School of Medicine, University of California, San Francisco 94143-0506.
Sawchuk
W S
WS
Leonardi
C
C
Langenberg
A
A
Tappero
J
J
Leboit
P E
PE
D000386:AIDS-Related Complex / Q000150:complications / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology; D000328:Adult; D015139:Blotting, Southern; D004279:DNA, Viral / Q000032:analysis; D004819:Epidermodysplasia Verruciformis / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D015658:HIV Infections / Q000150:complications*; D006679:HIV Seropositivity / Q000150:complications; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D012867:Skin / Q000473:pathology
D004279:DNA, Viral