title: Comparison of lisinopril versus atenolol for mild to moderate essential hypertension.
abstract: The antihypertensive effects and safety profiles of lisinopril (10 to 40 mg) and atenolol (50 to 100 mg) were compared in a randomized, double-blind, parallel group trial in 144 patients with essential hypertension. After 8 weeks of therapy, seated blood pressure (BP) decreased by 26/15 mm Hg with lisinopril and by 19/14 mm Hg with atenolol. Lisinopril produced a greater reduction (p less than 0.05) in sitting systolic BP than did atenolol. Standing BP decreased by 25/15 mm Hg with lisinopril and by 19/14 mm Hg with atenolol. No important changes in hematologic and biochemical profiles were seen with either drug. Eleven patients, 7 receiving lisinopril and 4 receiving atenolol, were withdrawn because of adverse experiences; another 3 patients defaulted during treatment, 1 in the lisinopril group and 2 in the atenolol group. Both drugs were well-tolerated and are therefore suitable for first-line therapy in essential hypertension.
authors.affiliation: Dudley Road Hospital, Birmingham, United Kingdom.
authors.forename: D G
authors.initials: DG
authors.lastname: Beevers
authors.forename: R A
authors.initials: RA
authors.lastname: Blackwood
authors.forename: S
authors.initials: S
authors.lastname: Garnham
authors.forename: M
authors.initials: M
authors.lastname: Watson
authors.forename: A A
authors.initials: AA
authors.lastname: Mehrzad
authors.forename: K
authors.initials: K
authors.lastname: Admani
authors.forename: J E
authors.initials: JE
authors.lastname: Angell-James
authors.forename: M
authors.initials: M
authors.lastname: Feely
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: M H
authors.initials: MH
authors.lastname: Husaini
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001262:Atenolol / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004656:Enalapril / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017706:Lisinopril; D008297:Male; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D001262:Atenolol; D004656:Enalapril; D017706:Lisinopril