title: Effects of nerve crush and transection on mRNA levels for nerve growth factor receptor in the rat facial motoneurons.
abstract: We found that the level of nerve growth factor receptor (NGF-R) mRNA in facial motoneurons was increased after both facial nerve crushing and transection by means of in situ hybridization histochemistry. The increased level of NGF-R mRNA was maintained for at least 8 weeks after facial nerve transection, while facial nerve crushing caused only a transient increase. Thus, expression of NGF-R mRNA paralleled the axonal regeneration process. In addition, the increase of NGF-R mRNA with crushing was more pronounced than with transection from the 3rd to the 14th day after the insult.
authors.affiliation: Department of Otolaryngology, Osaka University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Saika
authors.forename: E
authors.initials: E
authors.lastname: Senba
authors.forename: K
authors.initials: K
authors.lastname: Noguchi
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
authors.forename: M
authors.initials: M
authors.lastname: Tohyama
mesh_terms: D000818:Animals; D003714:Denervation; D005154:Facial Nerve / Q000378:metabolism / Q000502:physiology; D020220:Facial Nerve Injuries; D005786:Gene Expression Regulation; D008297:Male; D009046:Motor Neurons / Q000378:metabolism*; D009409:Nerve Crush; D009414:Nerve Growth Factors / Q000378:metabolism*; D009416:Nerve Regeneration; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics; D017475:Receptors, Nerve Growth Factor
chemical_list: D009414:Nerve Growth Factors; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor