Regulation of the early stages of T-cell development.
During the past year, there have been rapid advances in our understanding of the early events of T-cell development, at the molecular level. Studies at the transcriptional level of T-cell receptor gene regulation have started to yield important clues about how different T-cell-specific genes can share the same transcription factors and how alpha beta and gamma delta T cells are differentially regulated. In addition, studies using transgenic mice with the T-cell receptor gamma delta genes have further strengthened the separate lineage model of alpha beta and gamma delta T cells and brought into play the importance of negative cis-regulatory elements for lineage-specific determination.
Winoto
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University of California, Berkeley.
D000818:Animals; D001483:Base Sequence; D004742:Enhancer Elements, Genetic / Q000235:genetics; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013601:T-Lymphocytes / Q000166:cytology*; D014157:Transcription Factors / Q000235:genetics
D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D014157:Transcription Factors