title: Protein synthesis, cell growth and oncogenesis.
abstract: Two lines of investigation support a new hypothesis concerning the role of protein synthesis in the mitogenic pathway. The first is that a variety of mitogens and oncogene products increase phosphorylation and thereby activate eIF-4E, which is involved in the rate-limiting transfer of mRNA to ribosomes. The second is that overexpression or microinjection of eIF-4E induce rapid cell proliferation and oncogenic transformation.
authors.affiliation: University of Kentucky, Lexington.
authors.forename: R E
authors.initials: RE
authors.lastname: Rhoads
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D039561:Eukaryotic Initiation Factor-4E; D008934:Mitogens; D015513:Oncogene Proteins; D010448:Peptide Initiation Factors / Q000378:metabolism; D010766:Phosphorylation; D014176:Protein Biosynthesis
chemical_list: D039561:Eukaryotic Initiation Factor-4E; D008934:Mitogens; D015513:Oncogene Proteins; D010448:Peptide Initiation Factors