Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia.
Circulating levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol were studied in 86 patients with dementia; 45 with Alzheimer's disease and 41 with multi-infarct dementia. Compared to an elderly control group, after adjustment for age and sex, patients with Alzheimer's disease were found to have lower serum levels of DHEAS. We found a covariation between serum albumin and DHEAS levels, which may be of importance regarding peripheral hormone concentration in patients with dementia. These findings may provide evidence for a role of DHEAS in amnestic disorder in humans, either reflecting or contributing to the course of dementing diseases.
Näsman
B
B
Department of Geriatric Medicine, Umeå University Hospital, Sweden.
Olsson
T
T
Bäckström
T
T
Eriksson
S
S
Grankvist
K
K
Viitanen
M
M
Bucht
G
G
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis*; D001812:Blood-Brain Barrier / Q000502:physiology; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D015161:Dementia, Multi-Infarct / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology; D009483:Neuropsychological Tests; D011863:Radioimmunoassay; D012709:Serum Albumin / Q000378:metabolism
D012709:Serum Albumin; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone