title: The influence of maternal undernutrition in ovine twin pregnancy on fetal growth and Doppler flow-velocity waveforms.
abstract: The effects on placental blood flow velocity of maternal undernutrition during mid pregnancy were investigated in 38 twin bearing pregnant sheep by Doppler analysis of umbilical and uteroplacental arterial waveforms. Mid pregnancy undernutrition resulted in fetal growth restriction manifest at term gestation by reduced mean birth weight. Arterial waveform systolic/diastolic ratios from the umbilical and uteroplacental arterial circulations were not influenced by maternal nutrition either during the dietary deprivation or during a subsequent period of dietary supplementation. An effect of heart rate on systolic/diastolic ratios could not be demonstrated. The results indicate that the fetus responds to mid pregnancy maternal undernutrition with restricted growth but without alterations in systolic/diastolic ratios in umbilical or uteroplacental arterial waveforms.
authors.affiliation: King Edward Memorial Hospital for Women, Perth, Western Australia.
authors.forename: J P
authors.initials: JP
authors.lastname: Newnham
authors.forename: R W
authors.initials: RW
authors.lastname: Kelly
authors.forename: L
authors.initials: L
authors.lastname: Patterson
authors.forename: I
authors.initials: I
authors.lastname: James
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D003971:Diastole; D005314:Embryonic and Fetal Development; D005260:Female; D005865:Gestational Age; D006339:Heart Rate; D009747:Nutritional Physiological Phenomena; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D012756:Sheep; D013599:Systole; D014427:Twins