Identification and characterization of the gene for neurofibromatosis type 1.
Elucidation of the partial genomic structure and DNA sequence of the gene responsible for neurofibromatosis type 1, and discovery of clues to its function, have led to new opportunities not only for understanding this particular disease process, but also for clarifying signalling pathways involved in cellular growth and differentiation.
White
R
R
Howard Hughes Medical Institute, Salt Lake City, Utah.
O'Connell
P
P
D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D004247:DNA / Q000235:genetics; D016514:Genes, Neurofibromatosis 1; D011905:Genes, ras; D005819:Genetic Markers; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D015994:Incidence; D008954:Models, Biological; D005810:Multigene Family; D009456:Neurofibromatosis 1 / Q000453:epidemiology / Q000235:genetics*; D025542:Neurofibromin 1; D011506:Proteins / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction
D005819:Genetic Markers; D006133:Growth Substances; D025542:Neurofibromin 1; D011506:Proteins; D004247:DNA