The life shortening effects of treatment with doxorubicin and/or local irradiation on a cohort of young C3Hf/Sed mice.
The long-term consequences of treating a cohort of C3Hf/Sed mice in early life with either local-field single dose radiation, systemic doxorubicin, or both, are reported in this study. Significant life shortening was observed in all treatment groups. Median survival times (days) from time of treatment were: control, 690; 35 Gy, 560; 70 Gy, 460; 5 mg/kg doxorubicin, 580; 10 mg/kg doxorubicin, 350; 35 Gy + 5 mg/kg doxorubicin, 510; 70 Gy + 10 mg/kg doxorubicin, 310. Mice receiving hind limb irradiation died principally from induced sarcomas in a dose dependent fashion (80% after 70 Gy and 55% after 35 Gy). Those treated with doxorubicin alone showed an increase in the actuarial incidence of spontaneous malignancies but died mainly from non-malignant causes. Histological examination did not reveal any characteristic cardiac, renal or pulmonary lesions. Doxorubicin did not increase the rate of development of radiation induced sarcomas in mice treated with combined modality.
Zietman
A L
AL
Department of Radiotherapy, Mount Vernon Hospital, Northwood, Middlesex, U.K.
Suit
H D
HD
Okunieff
P G
PG
Donnelly
S M
SM
Dieman
S
S
Webster
S
S
D000818:Animals; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008136:Longevity / Q000187:drug effects* / Q000528:radiation effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009369:Neoplasms / Q000139:chemically induced; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*
D004317:Doxorubicin