title: Meta-analyses of the efficacy and tolerability of the tricyclic antidepressant lofepramine.
abstract: Lofepramine is a tricyclic antidepressant related to imipramine. Meta-analyses were carried out with respect to efficacy and tolerability by combining outcome and adverse reaction from over 20 controlled trials comparing lofepramine with other tricyclic antidepressants. Lofepramine was at least as effective as the comparators with fewer adverse effects. In particular, the risk/benefit ratio seemed superior to the comparators amitriptyline, imipramine, clomipramine, maprotiline and desipramine.
authors.affiliation: Merck-Clevenot, Nogent-sur-Marne, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Kerihuel
authors.forename: J F
authors.initials: JF
authors.lastname: Dreyfus
mesh_terms: D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D008127:Lofepramine / Q000009:adverse effects / Q000627:therapeutic use*; D015201:Meta-Analysis as Topic
chemical_list: D008127:Lofepramine