Effects of anthralin on mitochondrial bioenergetics.
Isolated mitochondria were used to determine what causes anthralin inhibition of oxidative phosphorylation. In good agreement with other results, the rate of oxygen consumption was not modified by anthralin when mitochondria were first uncoupled with FCCP, suggesting that only the last steps of the process leading to ATP phosphorylation are implicated. No effects were found at the level of the ATPase and the Pi carrier in contrast with a competitive inhibition of the ADP/ATP translocator. These experiments suggest an atractyloside-like effect to explain the action of anthralin on mitochondria.
Salet
C
C
Laboratoire de Biophysique, INSERM U 201 et CNRS URA 481, Muséum National d'Histoire Naturelle, Paris, France.
Moreno
G
G
Morlière
P
P
Santus
R
R
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000875:Anthralin / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats
D000226:Mitochondrial ADP, ATP Translocases; D000251:Adenosine Triphosphatases; D000875:Anthralin