Reflex responses in adrenal sympathetic nerves to stimulation of glucoreceptors and chemoreceptors in aging rats.
The age-related changes in the sensitivity of reflex responses of adrenal sympathetic nerve activity following stimulation of glucoreceptors and arterial chemoreceptors were investigated in young adult rats 4-5 months old and aged rats 24-26 months old. The sensitivity of the inhibitory reflex responses to stimulation of glucoreceptors and the sensitivity of excitatory reflex responses to systemic hypoxia with end-tidal O2 concentration at 8% and 6% were well maintained in the same ranges in aged rats as in young adult rats. The sensitivity of the excitatory reflex responses to mild systemic hypoxia with end-tidal O2 concentration at 10% increased slightly but significantly in aged rats compared with that in young adult rats.
Sato
A
A
Department of Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
Sato
Y
Y
Suzuki
H
H
Trzebski
A
A
D000311:Adrenal Glands / Q000294:innervation*; D000375:Aging / Q000502:physiology*; D000818:Animals; D002628:Chemoreceptor Cells / Q000502:physiology*; D004525:Efferent Pathways / Q000502:physiology / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D000860:Hypoxia / Q000503:physiopathology; D007275:Injections, Intravenous; D008297:Male; D009433:Neural Inhibition; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology* / Q000503:physiopathology
D011956:Receptors, Cell Surface; D005947:Glucose