Prevalence of serum neutralizing antibody to serotype 9 rotavirus WI61 in children from South America and central Europe.
Neutralizing serum antibody to serotype 9 rotavirus WI61 was detected in 41% of 870 Ecuadorian children and 26% of 140 German children. In both areas an age-related prevalence increase was observed. We identified 11 serum samples from Ecuadorian children which neutralized exclusively serotype 9 rotavirus. Thirteen of 71 (18%) German children hospitalized with serologically defined primary rotavirus gastroenteritis showed a seroconversion to serotype 9 rotavirus; however, in 10 of these 13 patients, the infecting serotype could be identified as serotype 1, 3, or 4. Furthermore, all 13 patients showed fourfold increases in titer to at least one further serotype.
Brüssow
H
H
Nestlé Research Centre, Nestec Ltd., Lausanne, Switzerland.
Clark
H F
HF
Sidoti
J
J
D000914:Antibodies, Viral / Q000032:analysis*; D004484:Ecuador / Q000453:epidemiology; D005756:Gastritis / Q000150:complications / Q000453:epidemiology; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007223:Infant; D009500:Neutralization Tests; D015995:Prevalence; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000150:complications / Q000453:epidemiology*
D000914:Antibodies, Viral