title: The mouse factor H allotypes with multiple amino acid replacement, H.1 and H.2 show indistinguishable co-factor activity for factor I.
abstract: The authors report the functional analysis of the purified mouse factor H allotypes H.1 and H.2, which were clearly distinguished from each other by an immunodiffusion test. Both allotypes acted as a co-factor for factor I in cleaving mouse C3b and we found no significant difference between their activities. The results strongly suggest that the function of mouse factor H for the co-factor activity has been well conserved between two allotypes.
authors.affiliation: Department of Immunobiology, Kanazawa University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Natsuume-Sakai
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Seya
authors.forename: M
authors.initials: M
authors.lastname: Nonaka
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: K
authors.initials: K
authors.lastname: Moriwaki
mesh_terms: D000483:Alleles; D000818:Animals; D003180:Complement C3b Inactivator Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D017242:Complement Factor H; D017244:Complement Factor I; D051379:Mice; D008970:Molecular Weight; D012697:Serine Endopeptidases / Q000502:physiology*; D014162:Transfection
chemical_list: D003180:Complement C3b Inactivator Proteins; D017242:Complement Factor H; D012697:Serine Endopeptidases; D017244:Complement Factor I