Plasma sodium-potassium ATPase inhibition activity in low- and normal-renin hypertension.
Thirty-seven subjects with low- and normal-renin hypertension (plasma renin activity less than 0.45 ng/L/sec on a 100 mmol Na diet) were studied on a 10 and 100 mmol sodium diet (100 mmol K and 25 mmol Ca) to examine the effect of varied sodium intake on plasma Na,K-ATPase inhibitory activity (NKAIA) (% inhibition). On the 10 mmol Na diet, plasma NKAIA correlated with mean arterial pressure (MAP) (r = 0.384, P = .019). On the 100 mmol Na diet, plasma NKAIA correlated with daily urinary sodium excretion (r = 0.384, P = .019). With the increase in sodium intake, the mean change in MAP was 0.5 +/- 7.8 mm Hg (range -12.7 to 16.3) and the mean change in plasma NKAIA was -4.2 +/- 11.2% inhibition (range -37.5 to 16). The change in MAP was correlated to the change in plasma NKAIA (r = 0.384, P = .019). Plasma NKAIA is related to mean arterial pressure or urinary sodium excretion depending on the dietary sodium intake, and is related to sodium-induced changes in MAP in low and normal renin hypertensive patients.
Keane
P
P
Foothills Provincial General Hospital, Faculty of Medicine, University of Calgary, Alberta, Canada.
Burgess
E
E
Watanabe
M
M
Wong
T
T
D000328:Adult; D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008137:Longitudinal Studies; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011188:Potassium / Q000652:urine; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine; D012982:Sodium, Dietary / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors* / Q000097:blood
D012982:Sodium, Dietary; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D009638:Norepinephrine