Relative changes in oxyhemoglobin, deoxyhemoglobin and intracranial blood volume during surfactant replacement therapy in infants with respiratory distress syndrome.
Oxy-, deoxyhemoglobin and total blood volume were studied by near-infrared spectroscopy (NIRS) during surfactant replacement therapy. These parameters were compared with parameters watched during conventional noninvasive monitoring (pulseoximetry, transcutaneous pO2 and pCO2, heart rate). Seven premature infants (28 +/- 3 weeks of gestation, 940 g birth weight) were given surfactant intratracheally. Immediately after surfactant administration, oxyhemoglobin decreased, deoxyhemoglobin and total blood volume increased. The prior status was re-established after 60-220 s and then oxyhemoglobin increased to a very stable maximum. NIRS allows continuous bedside noninvasive monitoring of all parameters.
Fahnenstich
H
H
Department of Neonatology, University of Bonn, FRG.
Schmidt
S
S
Spaniol
S
S
Kowalewski
S
S
D001785:Blood Gas Monitoring, Transcutaneous; D001810:Blood Volume / Q000187:drug effects; D002245:Carbon Dioxide / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007235:Infant, Premature, Diseases / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D010084:Oxidation-Reduction; D010108:Oxyhemoglobins / Q000187:drug effects / Q000378:metabolism*; D010313:Partial Pressure; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D013055:Spectrophotometry, Infrared / Q000379:methods
D006454:Hemoglobins; D010108:Oxyhemoglobins; D011663:Pulmonary Surfactants; D002245:Carbon Dioxide; C100003:deoxyhemoglobin