Prevention of primary prostate cancer in Lobund-Wistar rats by N-(4-hydroxyphenyl)retinamide.
We report for the first time that a synthetic retinoid, N-(4-hydroxyphenyl)retinamide, can prevent the development of both primary and metastatic tumors in an animal model of metastasizing primary prostate cancer. Prostatic adenocarcinomas were induced in high incidence in Lobund-Wistar rats by initiation with methylnitrosourea i.v. and promotion with testosterone. Feeding of N-(4-hydroxyphenyl)retinamide to these rats during the latency period markedly diminished the final incidence of both primary and metastatic prostate carcinomas.
Pollard
M
M
Lobund Laboratory, University of Notre Dame, Indiana 46556.
Luckert
P H
PH
Sporn
M B
MB
D000230:Adenocarcinoma / Q000517:prevention & control*; D000818:Animals; D000970:Antineoplastic Agents; D017313:Fenretinide; D008297:Male; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000517:prevention & control*; D051381:Rats; D011922:Rats, Mutant Strains; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000494:pharmacology
D000970:Antineoplastic Agents; D017313:Fenretinide; D014212:Tretinoin