title: Moderate exercise does not enhance the positive effect of estrogen on bone mineral density in postmenopausal women.
abstract: We studied the effects of physical activity and two types of estrogen treatment in a prospective study in 78 healthy postmenopausal women. A control group and two treatment groups receiving estradiol valerate and medroxyprogesterone acetate in 1- or 3-month cycles were monitored for 1 year. Half of each group took part in an exercise program. Lumbar and femoral bone mineral density increased in both of the estrogen-treatment groups. Physical exercise with estrogen treatment did not result in further increases in bone mineral densities.
authors.affiliation: Deaconess Institute of Oulu, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Heikkinen
authors.forename: E
authors.initials: E
authors.lastname: Kurttila-Matero
authors.forename: E
authors.initials: E
authors.lastname: Kyllönen
authors.forename: J
authors.initials: J
authors.lastname: Vuori
authors.forename: T
authors.initials: T
authors.lastname: Takala
authors.forename: H K
authors.initials: HK
authors.lastname: Väänänen
mesh_terms: D015519:Bone Density / Q000187:drug effects* / Q000502:physiology; D004958:Estradiol / Q000031:analogs & derivatives / Q000627:therapeutic use; D045166:Estradiol Congeners / Q000627:therapeutic use*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000031:analogs & derivatives / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate; D008593:Menopause; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D011446:Prospective Studies
chemical_list: D045166:Estradiol Congeners; D004958:Estradiol; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone