title: Regulation of cellular differentiation during Dictyostelium morphogenesis.
abstract: In Dictyostelium there are multiple prestalk cell types that have a complex pattern of directed cell movement during slug formation and culmination. Three extracellular signals, cyclic AMP, DIF and ammonia, control cell type differentiation. Recently there has been considerable progress in understanding their modes of action and interaction.
authors.affiliation: Clare Hall Laboratory, Imperial Cancer Research Fund, South Mimms, Herts, UK.
authors.forename: J G
authors.initials: JG
authors.lastname: Williams
mesh_terms: D000641:Ammonia / Q000494:pharmacology; D000818:Animals; D002465:Cell Movement; D004023:Dictyostelium / Q000166:cytology / Q000235:genetics / Q000254:growth & development* / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects / Q000528:radiation effects; D005800:Genes, Fungal; D006588:Hexanones / Q000378:metabolism; D008027:Light; D008954:Models, Biological; D009024:Morphogenesis / Q000235:genetics; D010422:Pentanones / Q000378:metabolism; D015800:Protozoan Proteins; D013172:Spores, Fungal
chemical_list: D005656:Fungal Proteins; D006588:Hexanones; D010422:Pentanones; D015800:Protozoan Proteins; C061925:spore coat proteins, Dictyostelium; C053433:1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone; C055365:1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl-)-1-pentanone; D000641:Ammonia