title: Orbital metastasis as the presenting sign of adenocarcinoma of the breast.
abstract: A 64-year-old woman presented with periorbital induration of 6 months' duration. Computed tomography (CT) revealed enlargement of extraocular muscles. A biopsy specimen of the orbicularis muscle and indurated preaponeurotic fat demonstrated an infiltrating carcinoma, and immunoperoxidase studies for surface antigens suggested a metastatic adenocarcinoma. Extensive evaluation revealed a 1-cm subareolar breast mass, with histopathological features identical to those of the orbital lesion. Orbital metastasis presenting before the diagnosis of a primary breast cancer is unusual, particularly in the absence of other disseminated disease.
authors.affiliation: Department of Ophthalmology, Medical College of Wisconsin, Milwaukee 53226.
authors.forename: L C
authors.initials: LC
authors.lastname: Glazer
authors.forename: G J
authors.initials: GJ
authors.lastname: Harris
authors.forename: K B
authors.initials: KB
authors.lastname: Simons
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009801:Oculomotor Muscles / Q000473:pathology; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000556:secondary*; D014057:Tomography, X-Ray Computed