title: Laminin binding proteins.
abstract: Cells express many proteins that bind to laminin, the major adhesive component of basement membranes. Some of these, specifically integrins, function as transmembrane receptors that 'signal' the presence of laminin on the cell surface to the cytoplasm. Lectins constitute a second class of laminin binding proteins that may augment integrin function by interacting with laminin carbohydrate. Caution must be used in ascribing functions to other laminin binding proteins, especially cytosolic proteins.
authors.affiliation: Laboratory of Cancer Biology, Deaconess Hospital, Harvard Medical School, Boston, MA 02115.
authors.forename: A M
authors.initials: AM
authors.lastname: Mercurio
authors.forename: L M
authors.initials: LM
authors.lastname: Shaw
mesh_terms: D000818:Animals; D003600:Cytosol / Q000378:metabolism; D016023:Integrins / Q000378:metabolism*; D007797:Laminin / Q000378:metabolism*; D037102:Lectins / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism*; D017474:Receptors, Laminin; D015398:Signal Transduction
chemical_list: D016023:Integrins; D007797:Laminin; D037102:Lectins; D009363:Neoplasm Proteins; D011971:Receptors, Immunologic; D017474:Receptors, Laminin