Fluctuation of fetal rat hepatic histidine decarboxylase activity through the glucocorticoid-ACTH system.
Our studies suggest that the fluctuation of HDC activity in fetal liver in late gestation is regulated by the plasma glucocorticoid level through the pituitary-adrenal system. Taken together, these results support the conclusion that glucocorticoid promotes a rapid increase in HDC synthesis in fetal liver histamine-forming cells, as well as in mouse mastocytoma P-815 cells and rat glandular stomachs.
Ohmori
E
E
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Imanishi
N
N
Ohgoh
M
M
Fukui
T
T
Ichikawa
A
A
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D005333:Fetus / Q000201:enzymology*; D006632:Histamine / Q000378:metabolism; D006640:Histidine Decarboxylase / Q000096:biosynthesis* / Q000097:blood; D008099:Liver / Q000196:embryology / Q000201:enzymology*; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D006632:Histamine; D000324:Adrenocorticotropic Hormone; D006640:Histidine Decarboxylase; D003345:Corticosterone