title: Synthesis of methylenecyclobutyl- and cyclobutenyl adenine A, potent antiviral carbocyclic analogues of oxetanocin A.
abstract: 9-Cyclobutyladenines bearing both methylene and hydroxymethyl groups, 3 and 4, were prepared by dehydration of carbocyclic oxetanocin A, 1a. Introduction of a double bond into cyclobutane ring was achieved by allylic oxidation of 12, which after several steps, afforded 5.
authors.affiliation: Department of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Maruyama
authors.forename: Y
authors.initials: Y
authors.lastname: Hanai
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry; D000241:Adenosine / Q000031:analogs & derivatives / Q000737:chemistry; D000998:Antiviral Agents / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000998:Antiviral Agents; C051061:oxetanocin; C012182:angustmycin A; C031096:neplanocin A; D000225:Adenine; D000241:Adenosine