Chlorhexidine mouthwash-induced fixed drug eruption. Case report and review of the literature.
Various adverse reactions including anaphylactic shock have already been reported after the topical application of chlorhexidine. This article reports for the first time a hypersensitivity reaction in the form of fixed drug eruption after the use of a mouthwash containing chlorhexidine. This report should bring an increased awareness of the possibility of systemic hypersensitivity reaction to chlorhexidine in a previously sensitized person. The report also will add fixed drug eruption to the list of skin hypersensitivity reactions caused by chlorhexidine.
Moghadam
B K
BK
Department of Oral Diagnosis and Radiology, University of Missouri, Kansas City.
Drisko
C L
CL
Gier
R E
RE
D002710:Chlorhexidine / Q000009:adverse effects* / Q000031:analogs & derivatives; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005533:Foot Dermatoses / Q000209:etiology; D006229:Hand Dermatoses / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D009067:Mouthwashes / Q000009:adverse effects; D010919:Placebos
D009067:Mouthwashes; D010919:Placebos; C010882:chlorhexidine gluconate; D002710:Chlorhexidine