Identification of a consistent pattern of mutations in neurovirulent variants derived from the sabin vaccine strain of poliovirus type 2.
Complete nucleotide sequencing of the RNAs of two unrelated neurovirulent isolates of Sabin-related poliovirus type 2 revealed that two nucleotides and one amino acid (amino acid 143 in the major capsid protein VP1) consistently departed from the sequences of the nonneurovirulent poliovirus type 2 712 and Sabin vaccine strains. This pattern of mutation appeared to be a feature common to all neurovirulent variants of poliovirus type 2.
Equestre
M
M
Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.
Genovese
D
D
Cavalieri
F
F
Fiore
L
L
Santoro
R
R
Perez Bercoff
R
R
D000595:Amino Acid Sequence; D001483:Base Sequence; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D004252:DNA Mutational Analysis; D004279:DNA, Viral; D008969:Molecular Sequence Data; D009154:Mutation; D017955:Poliovirus / Q000235:genetics / Q000472:pathogenicity*; D011055:Poliovirus Vaccine, Oral / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D013122:Spinal Diseases / Q000382:microbiology; D014774:Virulence / Q000235:genetics
D036022:Capsid Proteins; D004279:DNA, Viral; D011055:Poliovirus Vaccine, Oral; C442540:VP1 protein, Poliovirus