Cyclosporine inhibits T-cell activation at two distinct levels: role of the CD 28 activation pathway.
Hess
A D
AD
Bone Marrow Transplant Unit, Johns Hopkins University, Baltimore, Maryland 21205.
Bright
E C
EC
D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000911:Antibodies, Monoclonal / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology / Q000502:physiology*; D018106:CD28 Antigens; D017252:CD3 Complex; D003524:Cyclosporins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000096:biosynthesis; D007546:Isoquinolines / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology; D047428:Protein Kinase Inhibitors; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens; D017252:CD3 Complex; D003524:Cyclosporins; D007376:Interleukin-2; D007546:Isoquinolines; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011948:Receptors, Antigen, T-Cell; D015375:Receptors, Interleukin-2; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; C053177:N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide