Pharmacokinetic studies of hematoporphyrin derivatives on rat hepatocytes. Protoporphyrin dimethyl ester hematoporphyrin ether versus dihematoporphyrin ether-free hematoporphyrin derivative.
Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether. HL60 cells take up dimeric porphyrins in substantially higher quantities than hepatocytes do. These results allow the conclusion that physiological versus tumor cells behave differently with respect to porphyrin uptake: Whereas physiological cells prefer monomeric porphyrins, tumor cells preferentially incorporate dimeric porphyrins.
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Abteilung für Klinische Biochemie im Fachbereich Humanmedizin, Universität Marburg.
Häberlein
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Gressner
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Sieg
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Doss
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D000818:Animals; D017323:Dihematoporphyrin Ether; D006415:Hematoporphyrins / Q000493:pharmacokinetics*; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008297:Male; D011524:Protoporphyrins / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014407:Tumor Cells, Cultured
D006415:Hematoporphyrins; D011524:Protoporphyrins; C060688:protoporphyrin dimethyl ester hematoporphyrin ether; D017323:Dihematoporphyrin Ether