title: [Acute and chronic effect of moxisylyte hydrochloride on the retinal circulation in diabetes mellitus].
abstract: The effect of moxisylyte hydrochloride, a new type alpha 1-blocking vasodilator, on the retinal circulation was investigated in 14 diabetics, using the video-densitometric image analysis of fluorescein angiography. The build-up time (BT) and the mean circulation time (MCT) were compared before and after oral administration of moxisylyte. The BT one hour after oral administration of 30 mg moxisylyte was significantly shorter than that before therapy (artery; before 5.2 +/- 1.5 vs after 4.6 +/- 1.0 sec; p = 0.0001, vein; before 6.9 +/- 1.3 vs 6.3 +/- 1.1 sec; p = 0.0005). The MCT two weeks after oral administration of 90 mg per day moxisylyte was significantly shortened (before 3.6 +/- 2.3 vs after 2.6 +/- 1.4 sec; p = 0.0180). These results suggested that oral moxisylyte improved the retinal circulation and might support the concept that moxisylyte hydrochloride has clinical usefulness in patients with diabetes mellitus.
authors.affiliation: Department of Ophthalmology, School of Medicine, Yamaguchi University, Ube, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Sugihara
authors.forename: T
authors.initials: T
authors.lastname: Ishibashi
authors.forename: S
authors.initials: S
authors.lastname: Furutani
authors.forename: S
authors.initials: S
authors.lastname: Kurimoto
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013948:Moxisylyte / Q000008:administration & dosage / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D012171:Retinal Vessels / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D013948:Moxisylyte