Design of oligonucleotides for sequence-specific triple-helix formation. Properties of oligonucleotides containing 2'-deoxyxanthosine.
Homopyrimidine-homopurine sequences are targeted by homopyrimidine oligodeoxynucleotides to form triple helix structure. Xanthine was introduced to the third strand of pyrimidine-rich 15-mer oligodeoxy-nucleotides to recognize a cytosine in the purine strand in a homopyrimidine-homopurine duplex target.
Shimizu
M
M
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Inoue
H
H
Ohtsuka
E
E
D003853:Deoxyribonucleosides / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D003853:Deoxyribonucleosides; D009841:Oligonucleotides; C077801:2'-deoxyxanthosine