Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation.
The cdc2 protein kinase, first identified as a cell cycle gene required for transition into the S- and M-phases of budding and fission yeast, has been shown to act as a key component in the regulation of the eukaryotic cell cycle. The periodic activation of cdc2 kinase, which is required for entry into M-phase, is regulated by subunit association with cyclin B, the cdc25, wee1, mik1 gene products and differential phosphorylation of the cdc2 protein. Phosphorylation at Tyr 15 inhibits activation of the cdc2/cdc13 complex whereas phosphorylation of Thr 167 is required for kinase activity.
Fleig
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UN
Department of Cell Biology, School of Medicine, Vanderbilt University, Nashville, TN 37232.
Gould
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KL
D016203:CDC2 Protein Kinase / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology; D004789:Enzyme Activation; D010641:Phenotype; D010766:Phosphorylation; D012568:Schizosaccharomyces / Q000378:metabolism*
D016203:CDC2 Protein Kinase