Renal anemia in polycystic kidney disease mouse.
DBA/2FG-pcy mice developed the chronic renal failure by the progressive polycystic formation at five months old. Their bilaterally enlarged kidneys occupied about 15% of the body weight. It was about 9 times larger than the normal kidney of DBA/2N mice. A large number of various-sized cysts appeared in cortex and medulla of bilateral light-yellow kidneys of sponge-like shape. Blood urea nitrogen and creatinine increased. Red blood cells (746 +/- 39 x 10(4)/mm3), hemoglobin (8.8 +/- 0.4 g/dl) and hematocrits (31.1 +/- 1.5%) were lower than those of normal control mice. Serum erythropoietin level and reticulocytes did not increase. In addition, the treatment with exogenous erythropoietin improved the anemia in DBA/2FG-pcy mice. It was suggested that the anemia in DBA/2FG-pcy mice was due to the disorder of erythropoietin production caused by the progressive polycystic formation in kidneys.
Masunaga
H
H
Research Institute of Life Science, Snow Brand Milk Products Co., Lt., Tochigi, Japan.
Hirabayashi
M
M
Takahira
R
R
Imai
E
E
Kawanishi
G
G
D000740:Anemia / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004906:Erythrocyte Count / Q000662:veterinary; D004921:Erythropoietin / Q000097:blood / Q000494:pharmacology; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007668:Kidney / Q000473:pathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D007690:Polycystic Kidney Diseases / Q000150:complications / Q000662:veterinary*; D011994:Recombinant Proteins / Q000494:pharmacology; D012156:Reticulocytes; D012376:Rodent Diseases / Q000209:etiology*
D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin; D003404:Creatinine