Combined activity of trospectomycin and colloidal bismuth subcitrate against Helicobacter pylori in vitro.
The combined activities of trospectomycin, a spectinomycin analogue, and colloidal bismuth subcitrate against Helicobacter pylori were investigated, the agar dilution method being employed. Forty-seven strains of H. pylori were examined. An additive effect was observed in 89%, and a synergistic interaction in 11% of the isolates. There was no antagonism observed. The MIC50 of trospectomycin against H. pylori was 2 mg/l; the MIC ranged from 0.5 to 4 mg/l.
Vogt
K
K
Institut für Medizinische Mikrobiologie, Freie Universität Berlin.
Rodloff
A C
AC
Hahn
H
H
D000863:Antacids / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D016480:Helicobacter pylori / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000494:pharmacology*; D000198:Spectinomycin / Q000031:analogs & derivatives* / Q000494:pharmacology
D000863:Antacids; D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; C043267:trospectomycin; D000198:Spectinomycin; C002791:bismuth tripotassium dicitrate