Pharmacokinetics of tryptamide following intravenous administration in rats.
Plasma and tissue levels of N-3-pyridoyl-tryptamine (tryptamide) vs. time were determined in rats following iv administration of various doses: 6.25, 12.5, 25.0 and 37.5 mg/kg. The course of changes was described by the two-compartment open model. The distribution rate constant (alpha, min-1), the elimination rate constant (beta, min-1), the body clearance (Cltot, ml/min) and its fraction absorbed (f,%) values changed depending on the dose and were respectively: 0.107-0.266, 0.0068-0.0126, 5.39-11.59 and 31.77-66.70.
Szumiło
H
H
Department of Inorganic and Analytical Chemistry, Medical Academy, Lublin, Poland.
Lutnicki
K
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014363:Tryptamines / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014363:Tryptamines; D009536:Niacinamide; C057564:tryptamide