title: Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection.
abstract: Seventy-two AIDS patients treated with ganciclovir for cytomegalovirus (CMV) disease were prospectively monitored for the development of drug-resistant virus. No resistant strains were found in 31 patients before therapy or among seven culture-positive patients treated for less than or equal to 3 months. Of 13 culture-positive patients treated for greater than or equal to 3 months, 5 excreted virus resistant (ED50, greater than 12 microM, or ED90, greater than 30 microM) to ganciclovir. Thus, 38% of patients and receiving ganciclovir for greater than 3 months and excreting virus or, overall, 7.6% of the patients were excreting CMV resistant to the drug.
authors.affiliation: Virology Research, Mount Zion Hospital and Medical Center, University of California, San Francisco 94115.
authors.forename: W L
authors.initials: WL
authors.lastname: Drew
authors.forename: R C
authors.initials: RC
authors.lastname: Miner
authors.forename: D F
authors.initials: DF
authors.lastname: Busch
authors.forename: S E
authors.initials: SE
authors.lastname: Follansbee
authors.forename: J
authors.initials: J
authors.lastname: Gullett
authors.forename: S G
authors.initials: SG
authors.lastname: Mehalko
authors.forename: S M
authors.initials: SM
authors.lastname: Gordon
authors.forename: W F
authors.initials: WF
authors.lastname: Owen
authors.forename: T R
authors.initials: TR
authors.lastname: Matthews
authors.forename: W C
authors.initials: WC
authors.lastname: Buhles
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D003587:Cytomegalovirus / Q000187:drug effects*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy*; D004352:Drug Resistance, Microbial; D015774:Ganciclovir / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D011446:Prospective Studies; D011897:Random Allocation; D014556:Urine / Q000382:microbiology
chemical_list: D015774:Ganciclovir