title: Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14.
abstract: This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcr alpha, and Myhc alpha loci.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-6495.
authors.forename: M D
authors.initials: MD
authors.lastname: Traystman
authors.forename: L H
authors.initials: LH
authors.lastname: Chow
authors.forename: B M
authors.initials: BM
authors.lastname: McManus
authors.forename: A
authors.initials: A
authors.lastname: Herskowitz
authors.forename: M N
authors.initials: MN
authors.lastname: Nesbitt
authors.forename: K W
authors.initials: KW
authors.lastname: Beisel
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics; D002874:Chromosome Mapping; D002908:Chronic Disease; D003384:Coxsackievirus Infections / Q000235:genetics; D029822:Enterovirus B, Human; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D051379:Mice; D008815:Mice, Inbred Strains; D009205:Myocarditis / Q000235:genetics / Q000382:microbiology*; D010641:Phenotype