H-reflex latency and sensory conduction in the assessment of neuropathy in patients of chronic obstructive lung disease.
H-reflex latency, proximal conduction velocity and distal proprioceptive conduction velocity were studied along with distal motor and sensory conduction in 38 patients of chronic obstructive lung disease grouped according to age and duration of the disease, as well as in 35 age-matched smoker controls and 14 non-smoker controls. The mean values of all the parameters studied in all the patient groups were significantly different from those of the non-smoker control group. Smoker controls also showed significant abnormality in all the parameters except motor conduction velocity. Among the patients, significant abnormality (mean +/- greater than 2 SD) was seen in 44.7% in motor conduction, 86.8% in sural nerve distal latency, 97% in Ia conduction velocity, 78.9% in H-reflex latency and 60.5% in proximal conduction velocity, as compared to the non-smoker control values. Among the old patients with more than 10 years of the disease, 62.5% had all the parameters significantly abnormal. More than one parameter was affected in 97.4% of the patients. The intra-group and inter-group differences in all the parameters studied, except motor conduction velocity, were statistically significant indicating that age, chronicity of the disease and smoking can produce nerve conduction defects independently and collectively. It is suggested that though all parameters studied are highly sensitive to neuropathies, proximal H-latency studies are best suited for grading conduction defects in patients of chronic obstructive lung disease, since in many patients sural nerve action potential (52.63%) and distal H-reflex response for Ia conduction studies (81.52%) could not be elicited.(ABSTRACT TRUNCATED AT 250 WORDS)
Chandran
A P
AP
Department of Physiology, Medical College and Hospital, Rohtak, India.
Singal
K K
KK
Mahajan
S K
SK
Mahajan
K K
KK
Marya
R K
RK
D000328:Adult; D000367:Age Factors; D000368:Aged; D002908:Chronic Disease; D004594:Electrophysiology; D006181:H-Reflex / Q000502:physiology*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000503:physiopathology*; D011930:Reaction Time; D012129:Respiratory Function Tests; D012907:Smoking / Q000503:physiopathology