title: Human papillomavirus segregation patterns in genital and nongenital warts in prepubertal children and adults.
abstract: This study compared the segregation patterns of human papillomavirus (HPV) in genital and nongenital warts in prepubertal children and adults. HPV 2 was detected in most nongenital warts in children and adults, whereas neither HPV 6 or 11 was detected at nongenital sites in either group with the use of in situ or Southern blot hybridization analyses. Of nine genital tract lesions in children. HPV 2 was detected in two and HPV 6 or 11 in six. More than 90% of cases of regional tract condylomata in adults contained HPV 6 or 11. HPV 2 was not detected in any of 99 genital tract lesions in adults. It is concluded that HPV 6/11 cannot proliferate at nongenital cutaneous sites and HPV 2 can proliferate in the genital tract of children but not adults. Thus, the detection of HPV 6 or 11 in a genital wart in a child implies, assuming cutaneous transmission, infection from a genital site, whereas the detection of HPV 2 presumes nongenital transmission.
authors.affiliation: Department of Pathology, Columbia Presbyterian Medical Center, New York, New York.
authors.forename: G J
authors.initials: GJ
authors.lastname: Nuovo
authors.forename: D A
authors.initials: DA
authors.lastname: Lastarria
authors.forename: S
authors.initials: S
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Lerner
authors.forename: S L
authors.initials: SL
authors.lastname: Comité
authors.forename: Y D
authors.initials: YD
authors.lastname: Eliezri
mesh_terms: D000328:Adult; D015139:Blotting, Southern; D002648:Child; D002675:Child, Preschool; D003218:Condylomata Acuminata / Q000737:chemistry / Q000382:microbiology*; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D005836:Genitalia, Female / Q000737:chemistry / Q000382:microbiology; D005837:Genitalia, Male / Q000737:chemistry / Q000382:microbiology; D006801:Humans; D007223:Infant; D008297:Male; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D012867:Skin / Q000737:chemistry / Q000382:microbiology; D014860:Warts / Q000382:microbiology*
chemical_list: D015342:DNA Probes; D004279:DNA, Viral