The calcium antagonist PN 200-110 inhibits the reinforcing properties of cocaine.
The effect of a dihydropyridine (DHP) calcium antagonist, PN 200-110, on cocaine reinforcing properties was investigated using conditioned place preference paradigm. PN 200-110 in nonsedative doses (0.62-1.25-2.5 mg/kg SC) was able to inhibit cocaine-(10 mg/kg IP) induced place preference with ED50 1.57 (0.88-2.58). The results suggest a possible use of DHPs in the treatment of cocaine-related disorders.
Pani
L
L
B. B. Brodie, Department of Neuroscience, University of Cagliari, Italy.
Kuzmin
A
A
Martellotta
M C
MC
Gessa
G L
GL
Fratta
W
W
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003042:Cocaine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D017275:Isradipine; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010069:Oxadiazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology
D002121:Calcium Channel Blockers; D010069:Oxadiazoles; D003042:Cocaine; D017275:Isradipine