[Spontaneous migration and adherence of leukocytes and the NBT test of peripheral blood neutrophils in patients with iron deficiency anemia].
Literature reports suggest that iron-deficiency may contribute to the development or intensification of the condition termed generally "immunodeficiency". In the available literature no reports were found on a precise evaluation of the functions of peripheral blood neutrophils in iron deficiency anaemia. The purpose of the presented study was: 1) estimation of the adherence of neutrophils from peripheral blood to fibres, 2) evaluation of the indices of spontaneous and latex-stimulated NBT reduction by the neutrophils, and 3) the test of spontaneous migration of peripheral blood leucocytes. The study of 20 patients with iron-deficiency anaemia, with counts of total leucocytes and absolute neutrophil count in peripheral blood showed increased adherence of the neutrophils and reduced spontaneous migration of leucocytes in the 3-hour test, but no changes in the test of spontaneous and latex-stimulated NBT reduction. In the discussion an interpretation of the observed abnormalities in the studied biological functions of the neutrophils in patients with iron-deficiency anaemia is tentatively put forward, stressing that in this anaemia despite absence of changes in the counts of peripheral blood neutrophils, spontaneous migration of peripheral blood neutrophils in the 3-hour test is reduced, perhaps as a result of increased adherence of neutrophils.
Hrycek
A
A
II Katedra i Klinika Chorób Wewnetrznych, Slaskiej Akademii Medycznej, Katowicach.
Kalina
Z
Z
Badowski
R
R
Wartalska
G
G
D000328:Adult; D000747:Anemia, Hypochromic / Q000276:immunology*; D002448:Cell Adhesion / Q000276:immunology; D002464:Cell Migration Inhibition; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D005260:Female; D006801:Humans; D007957:Leukocyte Adherence Inhibition Test; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology* / Q000473:pathology; D009504:Neutrophils / Q000276:immunology* / Q000473:pathology; D009580:Nitroblue Tetrazolium; D010587:Phagocytosis / Q000276:immunology*
D009580:Nitroblue Tetrazolium
Migracja spontaniczna leukocytów oraz adherencja i test NBT granulocytów obojetnochłonnych krwi obwodowej u chorych z niedokrwistościa z niedoboru zelaza.