[The surface-active properties of dimethylethanolamine and its effect on the ecto-ATPase activity of plasma membranes].
It has been stated that DMAE has low surface activity and can form extended monolayers, in which orientation of molecules depends on the concentration of amino alcohol. The concentration of DMAE rated as 10(-6)-10(-5) M does not show significant changes in ecto-ATPase. Effect of such concentration is completely reversible. Cytotoxic effect manifesting itself by a sharp decrease and blocking ecto-ATPase activity is not completely reversible and appears at DMAE concentrations higher than 10(-4) M.
Rybal'chenko
V K
VK
Lukoshko
S A
SA
Ostrovskaia
G V
GV
Kulikova
N V
NV
D000251:Adenosine Triphosphatases / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D002463:Cell Membrane Permeability / Q000187:drug effects; D003642:Deanol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D008452:Maximum Allowable Concentration; D008564:Membrane Potentials / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000201:enzymology; D011817:Rabbits; D013501:Surface-Active Agents
D013501:Surface-Active Agents; D003642:Deanol; D000251:Adenosine Triphosphatases; C027201:ectoATPase
Poverkhnostno-aktivnye svoĭstva dimetilétanolamina i ego vliianie na ékto-ATFaznuiu aktivnost' plazmaticheskikh membran.