title: Liquorpheresis (CSF-filtration): an effective treatment in acute and chronic severe autoimmune polyradiculoneuritis (Guillain-Barré syndrome).
abstract: In recent years, plasmapheresis has become a well established treatment of acute and chronic polyradiculoneuritis (Guillain-Barré syndrome, GBS). Nevertheless, there are still non-responders and there are particular risks associated with this treatment. Despite all efforts, the duration of severe forms of Guillain-Barré syndrome is still considerable. Inflammation and demyelination start intrathecally. We therefore used liquorpheresis (cerebrospinal fluid filtration) as a new effective therapeutic approach. Our first patient, severely disabled with acute GBS, artificially ventilated, had undergone plasma exchange without effect. Plasma immunoadsorption led only to transient improvement. After several liquorphereses, the patient recovered completely. In three additional patients with acute and two with chronic GBS an improvement of clinical signs in close temporal relation to liquorpheresis was observed. Twice, liquorpheresis was combined with immunoadsorption of cerebrospinal fluid. Liquorpheresis was well tolerated in all cases. This procedure may be effective by eliminating humoral or cell-bound factors responsible for the onset or/and maintenance of inflammation. Further controlled studies are necessary and are in progress.
authors.affiliation: Department of Anaesthesiology/Intensive Care Medicine, Rehabilitation Hospital Ulm, Academic Hospital of the University, Federal Republic of Germany.
authors.forename: K H
authors.initials: KH
authors.lastname: Wollinsky
authors.forename: M
authors.initials: M
authors.lastname: Weindler
authors.forename: P J
authors.initials: PJ
authors.lastname: Hülser
authors.forename: P
authors.initials: P
authors.lastname: Geiger
authors.forename: N
authors.initials: N
authors.lastname: Matzek
authors.forename: H H
authors.initials: HH
authors.lastname: Mehrkens
authors.forename: H H
authors.initials: HH
authors.lastname: Kornhuber
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000134:cerebrospinal fluid* / Q000503:physiopathology / Q000628:therapy*; D001781:Blood Component Removal / Q000379:methods*; D002556:Cerebrospinal Fluid Proteins / Q000502:physiology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D009460:Neurologic Examination; D011129:Polyradiculoneuropathy / Q000134:cerebrospinal fluid* / Q000503:physiopathology / Q000628:therapy*; D013116:Spinal Cord / Q000503:physiopathology; D013126:Spinal Nerve Roots / Q000503:physiopathology
chemical_list: D002556:Cerebrospinal Fluid Proteins