Effects of nitroscanate on adult Taenia pisiformis in dogs with experimentally induced infections.
Twenty-four specific-pathogen-free Beagles were each given 50 cysticerci of Taenia pisiformis that had been harvested from experimentally infected rabbits. Quantitative fecal egg counts and fecal screening for recovery of passed segments were performed on postinoculation days 56 through 70. Twenty-three of 24 dogs fed cysticerci developed patent infections. The 23 dogs with patent infections were assigned to 1 of 2 groups and treated with nitroscanate or a placebo 60 days after inoculation. Egg counts in the treated dogs had markedly decreased by the second day after treatment, and by the sixth day after treatment, segments were not found in the feces of any of the treated animals. The control dogs continued to pass eggs and segments in their feces throughout the 9 days after treatment. The dogs were euthanatized and necropsied 70 days after being inoculated. At necropsy, the mean number of scolices recovered from control dogs was 24.6, the mean number of scolices recovered from treated dogs was 0.25. Worms recovered from the control dogs were intact, gravid cestodes. Efficacy of treatment with nitroscanate at a mean dosage of 56 mg/kg of body weight was 98.9%.
Bowman
D D
DD
Department of Microbiology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Lin
D S
DS
Johnson
R C
RC
Lynn
R C
RC
Hepler
D I
DI
Stansfield
D G
DG
D000818:Animals; D000923:Anticestodal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005243:Feces / Q000469:parasitology; D005260:Female; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D010647:Phenyl Ethers / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D013047:Specific Pathogen-Free Organisms; D013621:Taenia / Q000187:drug effects / Q000302:isolation & purification; D013622:Taeniasis / Q000188:drug therapy / Q000662:veterinary*; D013861:Thiocyanates / Q000494:pharmacology / Q000627:therapeutic use*
D000923:Anticestodal Agents; D010647:Phenyl Ethers; D013861:Thiocyanates; C011042:nitroscanate