title: Iodine 131 metaiodobenzylguanidine scintigraphy of medullary carcinoma of the thyroid.
abstract: We have presented a case of sporadic medullary carcinoma of the thyroid with documentation of localization of tracer 131I-MIBG within the primary neoplasm. A review of the nuclear medicine literature of localization techniques for MCT demonstrates that 131I-MIBG, while an excellent choice for diagnosis of pheochromocytoma and neuroblastoma, produces low yield and unpredictable concentration in other neural crest apudomas, including MCT. A low incidence of true-positive results with 131I-MIBG uptake and a high incidence of false-negative results make this radiopharmaceutical a suboptimal choice for diagnostic studies, but a potentially promising one as a therapeutic agent.
authors.affiliation: Department of Medicine, University Medical Center, University of Florida School of Medicine, Jacksonville 32209.
authors.forename: W R
authors.initials: WR
authors.lastname: Skowsky
authors.forename: L H
authors.initials: LH
authors.lastname: Wilf
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000627:therapeutic use; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D015609:Organotechnetium Compounds; D019797:3-Iodobenzylguanidine; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer