title: Evidence for the secretion of inhibin-like immunoreactivity from cultured human adrenal cells.
abstract: We have studied the production and release of inhibin-like immunoreactivity in the human adrenal gland. Extract of human adrenal glands showed a displacement curve paralleled with the inhibin standard. Inhibin-like immunoreactivity contents in the adrenal gland was 1893 +/- 474 (mean +/- S.D.) IU/g wet weight tissue. ACTH stimulated the secretion of inhibin-like immunoreactivity as well as cortisol and aldosterone in a dose-dependent manner in the cultured adrenal cells. These results indicate that the human adrenal gland produces and secretes inhibin-like peptide in response to ACTH.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Haji
authors.forename: Y
authors.initials: Y
authors.lastname: Nishi
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Ohashi
authors.forename: K
authors.initials: K
authors.lastname: Sekiya
authors.forename: Y
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: M
authors.initials: M
authors.lastname: Igarashi
authors.forename: S
authors.initials: S
authors.lastname: Sasamoto
authors.forename: H
authors.initials: H
authors.lastname: Nawata
mesh_terms: D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000378:metabolism; D000937:Antigen-Antibody Reactions; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007265:Inhibins / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
chemical_list: D000450:Aldosterone; D007265:Inhibins; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone