title: Inhibition of intergeneric coaggregation among oral bacteria by cetylpyridinium chloride, chlorhexidine digluconate and octenidine dihydrochloride.
abstract: The potential inhibitory effect of chlorhexidine digluconate on the intergeneric coaggregation of 11 pairs of Gram-positive organisms was compared to its ability to inhibit coaggregations of 14 pairs comprised of both a Gram-positive and a Gram-negative cell type. Dramatic differences in the inhibitory effectiveness of the antimicrobial compound on the two kinds of coaggregation pairs were found. Gram-positive pairs were not inhibited at a concentration of 0.25%, whereas the coaggregations involving a Gram-negative partner were usually completely blocked at concentrations as low as 0.01%. Similar effects to chlorhexidine digluconate were found with octenidine dihydrochloride and cetylpyridinium chloride, while sodium dodecylsulfate was inhibitory only at 10- to 50-fold higher concentrations. These results suggest that chlorhexidine digluconate, octenidine dihydrochloride, and cetylpyridinium chloride may be effective inhibitors of later microbial colonizers of dental plaque but may not disturb a normal healthy indigenous flora.
authors.affiliation: Laboratory of Microbial Ecology, National Institute of Dental Research, Bethesda, Maryland.
authors.forename: R N
authors.initials: RN
authors.lastname: Smith
authors.forename: R N
authors.initials: RN
authors.lastname: Andersen
authors.forename: P E
authors.initials: PE
authors.lastname: Kolenbrander
mesh_terms: D000190:Actinomyces / Q000187:drug effects; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D002594:Cetylpyridinium / Q000494:pharmacology*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003773:Dental Plaque / Q000382:microbiology* / Q000517:prevention & control; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D007097:Imines; D011725:Pyridines / Q000494:pharmacology*; D013045:Species Specificity; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000891:Anti-Infective Agents, Local; D007097:Imines; D011725:Pyridines; D002594:Cetylpyridinium; C010882:chlorhexidine gluconate; C034213:octenidine; D002710:Chlorhexidine