title: Rabbit haemorrhagic disease: an investigation of some properties of the virus and evaluation of an inactivated vaccine.
abstract: An inactivated vaccine against rabbit haemorrhagic disease (RHD), developed and tested in our laboratory, is produced commercially by Bioveta, Ivanovice, Czechoslovakia. Rabbits developed full protection against infection 3 weeks after the administration of a single dose. Antibodies were detectable from day 5 after vaccination. Naturally acquired antibodies were demonstrated in some rabbits kept on commercial farms. The virus survived at least 225 days in an organ suspension kept at 4 degrees C, at least 105 days in the dried state on cloth at room temperature (around 20 degrees C), and at least 2 days at 60 degrees C, both in organ suspension and in the dry state. Experimental infection of rabbits younger than 2 months was successful in some animals. Hares, guinea pigs, white mice, golden and Chinese hamsters, chinchillas and hysterectomy-derived, colostrum-deprived piglets were resistant to infection.
authors.affiliation: Veterinary Research Institute, Brno, Czechoslovakia.
authors.forename: B
authors.initials: B
authors.lastname: Smíd
authors.forename: L
authors.initials: L
authors.lastname: Valícek
authors.forename: L
authors.initials: L
authors.lastname: Rodák
authors.forename: J
authors.initials: J
authors.lastname: Stĕpánek
authors.forename: E
authors.initials: E
authors.lastname: Jurák
mesh_terms: D000367:Age Factors; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002139:Caliciviridae / Q000254:growth & development / Q000276:immunology* / Q000648:ultrastructure; D002682:Chinchilla; D006224:Cricetinae; D003412:Cricetulus; D004198:Disease Susceptibility; D006168:Guinea Pigs; D007793:Lagomorpha; D008647:Mesocricetus; D051379:Mice; D008854:Microscopy, Electron; D010850:Picornaviridae Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D011817:Rabbits; D013045:Species Specificity; D013552:Swine; D013696:Temperature; D015164:Vaccines, Inactivated / Q000276:immunology / Q000592:standards; D014765:Viral Vaccines / Q000276:immunology / Q000592:standards*
chemical_list: D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines