title: Geographical variance in the risk of gastric stump cancer: no increased risk in Japan?
abstract: Geographical differences may exist in the risk of gastric stump cancer. Therefore, we performed meta-analysis of literature reports in Japan (n = 3), the USA (n = 4), and Europe (n = 20) on the risk of postgastrectomy cancer. The weighted mean relative risk of stump cancer in Japan was 0.28, 95% confidence limits 0.21-0.38 as compared to 1.53, 95% confidence limits 0.98-2.41 in the USA and 1.66, 95% confidence limits 1.55-1.79 in Europe. Thus, the risk of gastric cancer in the post-gastrectomy patient seems decreased in Japan and is significantly less than in the USA or Europe, where an increased risk exists. Since there is a high risk of gastric cancer of the intact stomach in Japan, the discovery of a low cancer risk in the gastric stump may provide evidence that these gastric cancers are two different entities.
authors.affiliation: Department of Clinical Epidemiology, University Hospital Leiden, The Netherlands.
authors.forename: A C
authors.initials: AC
authors.lastname: Tersmette
authors.forename: F M
authors.initials: FM
authors.lastname: Giardiello
authors.forename: G J
authors.initials: GJ
authors.lastname: Offerhaus
authors.forename: K W
authors.initials: KW
authors.lastname: Tersmette
authors.forename: K
authors.initials: K
authors.lastname: Ohara
authors.forename: J P
authors.initials: JP
authors.lastname: Vandenbroucke
authors.forename: G N
authors.initials: GN
authors.lastname: Tytgat
mesh_terms: D004381:Duodenal Ulcer / Q000601:surgery*; D005060:Europe; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D005843:Geography; D006801:Humans; D015994:Incidence; D007564:Japan; D008297:Male; D015201:Meta-Analysis as Topic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000209:etiology; D013276:Stomach Ulcer / Q000601:surgery*; D014481:United States