title: Some prognostic factors for the development of transplant-related coronary artery disease in human cardiac allografts.
abstract: The study of endomyocardial biopsy specimens taken in the first 130 days after transplantation has yielded no histologic features predictive of later development of transplant-related coronary artery disease. This study, however, indicated that a combination of the following factors might be predictive in cyclosporine-treated patients: untreated histologically proven episodes of rejection, infection with cytomegalovirus or reactivation of infection, ischemic heart disease in the recipient as the reason for heart transplantation, and possibly HLA-B5 or -B8 mismatch.
authors.affiliation: Papworth Hospital, Papworth Everard, Cambridge, England.
authors.forename: P G
authors.initials: PG
authors.lastname: Stovin
authors.forename: L
authors.initials: L
authors.lastname: Sharples
authors.forename: J A
authors.initials: JA
authors.lastname: Hutter
authors.forename: J
authors.initials: J
authors.lastname: Wallwork
authors.forename: T A
authors.initials: TA
authors.lastname: English
mesh_terms: D000328:Adult; D001706:Biopsy; D003324:Coronary Artery Disease / Q000150:complications; D003327:Coronary Disease / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D003524:Cyclosporins / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000150:complications; D005260:Female; D006084:Graft Rejection; D015235:HLA-B Antigens / Q000032:analysis; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors
chemical_list: D003524:Cyclosporins; D015235:HLA-B Antigens