title: 19F-MRI of stomach and intestine using 50% FTPA emulsion under 2 T MRI system.
abstract: 1H-MRI is of clinical value in many lesions, but imaging of gastrointestinal lesions is still difficult by 1H-MRI. To overcome this weak point of 1H-MRI, rabbit stomachs were examined by 19F-MRI using 50% FTPA emulsion. We also examined the stability of 50% FTPA emulsion in the stomach and its absorption from the gastrointestinal tract. We found that 50% FTPA emulsion was very stable at pH 1.5, and only a very small amount was absorbed. A rabbit (weighing 2 kg) was anesthetized, and 100 ml of 50% FTPA emulsion was infused into the stomach by catheter. 19F-MRI was performed in this rabbit using a 2 T superconducting MRI system designed for human use, and clear pictures of the stomach were obtained. From our results we conclude that 19F-MRI of the stomach using 50% FTPA emulsion is of practical value.
authors.affiliation: Second Department of Surgery, Osaka University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Mishima
authors.forename: Y
authors.initials: Y
authors.lastname: Tamaki
authors.forename: T
authors.initials: T
authors.lastname: Shimano
authors.forename: C
authors.initials: C
authors.lastname: Shimizu
authors.forename: Y
authors.initials: Y
authors.lastname: Higuchi
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
mesh_terms: D000818:Animals; D003287:Contrast Media; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D007408:Intestinal Absorption; D007422:Intestines / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011817:Rabbits; D013270:Stomach / Q000033:anatomy & histology*
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination