Atrial natriuretic peptide and urinary sodium balance during physical exercise.
Atrial natriuretic peptide (ANP), plasma renin activity (PRA), plasma aldosterone and urinary fractional excretion of sodium (%FENa) were measured in 22 athletes before and after 1 h running. After exercise the hormones increased significantly, while %FENa decreased. In fact, the percent PRA increases resulted higher than the percent ANP increases with a significant inverse correlation. It is concluded that hemodynamic changes during strenuous and prolonged physical exercise lead to the inhibition of the natriuretic properties of ANP by stimulating the renin-angiotensin-aldosterone system, although a feedback mechanism of modulation between ANP and PRA seems to occur.
De Paoli Vitali
E
E
Divisione di Nefrologia, Arcispedale S. Anna, Italia.
Malacarne
F
F
Vedovato
M
M
Cavallini
R
R
Bagni
B
B
Nunzi
L
L
Gilli
P
P
D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000378:metabolism* / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005246:Feedback / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D012083:Renin / Q000097:blood / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D012964:Sodium / Q000652:urine*
D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012964:Sodium; D012083:Renin