Incomplete proviral genome of mouse mammary tumour virus is present on chromosome Y of NIH Swiss and some genetically related mouse strains.
An incomplete proviral genome of endogenous mammary tumour virus (MMTV) was found in DNA of several strains of mice. This MMTV-related sequence was assigned to the Y chromosome since it was clearly observed in male mice only. This MMTV provirus contained a sequence related to LTR (long terminal repeat), but not to gag-pol and env genes. NFS, NIH Swiss/S, STS/A, and DD/Tbr mice have this sequence but BALB/cHeA, SHN, SLN, C57BL/6NJcl, C3H/HeNJcl and CBA/JJcl mice are negative. In the strains containing this sequence, a DNA test for the sequence makes it possible to easily distinguish the DNAs of male or female mice.
Nishikawa
R
R
Department of Applied Bioscience, University of Osaka Prefecture, Japan.
Okumoto
M
M
Iwai
M
M
Iwai
Y
Y
Takamori
Y
Y
Imai
S
S
Hilgers
J
J
D000818:Animals; D004247:DNA / Q000737:chemistry; D015342:DNA Probes; D005260:Female; D008297:Male; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000382:microbiology; D011533:Proviruses / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D014998:Y Chromosome / Q000648:ultrastructure*
D015342:DNA Probes; D004247:DNA