A double-blind comparative study of doxazosin and prazosin in the treatment of essential hypertension.
Two hundred sixty-six patients took part in a multicenter comparative study of doxazosin and prazosin. Both drugs produced a significant reduction (p less than 0.001) in blood pressure and no increase in heart rate. Blood pressure was considered "markedly decreased" or "decreased" in 70.8% of patients treated with doxazosin and 70.0% of patients treated with prazosin. No statistically significant between-group differences in antihypertensive efficacy were observed. Both doxazosin and prazosin were well tolerated; seven patients (5.6%) in each group had the therapy withdrawn.
Fukiyama
K
K
Third Department of Internal Medicine, University of Ryukyus, School of Medicine, Okinawa, Japan.
Omae
T
T
Iimura
O
O
Yoshinaga
K
K
Yagi
S
S
Inagaki
Y
Y
Ishii
M
M
Kaneko
Y
Y
Yamada
K
K
Ijichi
H
H
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D017292:Doxazosin; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D017292:Doxazosin; D011224:Prazosin