[Induction of interleukin-1 synthesis. A new criterion of biocompatibility of extracorporeal circuits].
The interaction of plasma with artificial surfaces may result in activation of the complement system with release of the anaphylatoxins C3a and C5a. Some of the biological effects of the anaphylatoxins do not occur immediately since they require de novo protein synthesis, such as the production of the proinflammatory cytokines IL-1, IL-6 and TNF alpha by activated monocytes. We have demonstrated that complement activation is associated with the acute ad transient induction of IL-1 production in patients undergoing hemodialysis with complement activating cellulosic membranes. In patients dialyzed with non-complement activating membranes, a chronic induction of IL-1 production is observed, which may be due to transmembrane passage into the blood compartment of endotoxins contaminating the dialysate. Induction of IL-1 production also occurs in patients undergoing cardiopulmonary bypass. Induction of monocytic interleukins synthesis may be considered a novel criterion of biocompatibility of artificial surfaces for medical use.
Haeffner-Cavaillon
N
N
INSERM U28, Unité d'Immunopathologie, Hôpital Broussais, Paris.
Kazatchkine
M D
MD
D001672:Biocompatible Materials; D006348:Cardiac Surgical Procedures / Q000295:instrumentation; D005112:Extracorporeal Circulation / Q000295:instrumentation*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D006435:Renal Dialysis / Q000295:instrumentation
D001672:Biocompatible Materials; D007375:Interleukin-1
Induction de la synthèse d'interleukine-1. Un nouveau critère de biocompatibilité des circuits extracorporels.