title: Synthesis of some oligodeoxynucleotides containing the C-nucleoside and 2'-deoxy-2'-fluoronucleoside moieties.
abstract: An automated computer-controlled, multipurpose synthesizer, featuring a novel method for the transport of liquids, was constructed and used in the synthesis of oligomers containing some C-nucleoside and 2'-deoxy-2'-fluoronucleoside moieties by the H-phosphonate procedure. The synthetic method and some prospects for biological use are outlined.
authors.affiliation: Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division of Graduate School of Medical Sciences, Cornell University, New York, NY 10021.
authors.forename: I
authors.initials: I
authors.lastname: Rosenberg
authors.forename: Z
authors.initials: Z
authors.lastname: Tocik
authors.forename: K A
authors.initials: KA
authors.lastname: Watanabe
mesh_terms: D001483:Base Sequence; D003201:Computers; D005461:Fluorine; D007202:Indicators and Reagents; D008969:Molecular Sequence Data; D009705:Nucleosides; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D009705:Nucleosides; D009838:Oligodeoxyribonucleotides; D005461:Fluorine