Chronic neonatal MK-801 administration leads to a long-lasting increase in seizure sensitivity during the early stages of hippocampal kindling.
Persistent effects of chronic neonatal administration of the N-methyl-D-aspartate (NMDA) antagonist MK-801 were investigated by measuring susceptibility to CA1 kindling epileptogenesis in adulthood. Rat pups were chronically treated with MK-801 from postnatal day 8 through day 19. Hippocampal kindling showed an increase in electrical seizure duration in the MK-801-treated group as compared with controls along with a more severe expression of behavioral seizures during the first few kindling stimulations. These results show that neonatal interference with NMDA receptor function leads to a long-lasting increase in hippocampal excitability.
Gorter
J A
JA
Netherlands Institute for Brain Research, Amsterdam.
Titulaer
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M
Bos
N P
NP
Huisman
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E
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D004198:Disease Susceptibility / Q000139:chemically induced; D016291:Dizocilpine Maleate / Q000494:pharmacology / Q000633:toxicity*; D004558:Electric Stimulation; D004827:Epilepsy / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D006624:Hippocampus / Q000503:physiopathology*; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000502:physiology
D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate