DL-alpha-difluoromethylornithine (DFMO)-Berenil combination: therapeutic and prophylactic activity against Trypanosoma brucei brucei infection in mice.
The therapeutic and prophylactic activity of difluoromethylornithine (DFMO) (2% in drinking water for 4 days) and Berenil (7 mg/kg live weight intraperitoneally) combination was investigated in mice infected with Trypanosoma brucei brucei. Using a previously described mouse model of the African trypanosomosis of the central nervous system, it was demonstrated that the combination was curative and acted synergistically. However, if used prophylactically it had no advantage over Berenil alone.
Onyeyili
P A
PA
Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria.
Egwu
G O
GO
Zaria
L T
LT
Orjiude
B A
BA
D000818:Animals; D004133:Diminazene / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D000518:Eflornithine / Q000627:therapeutic use*; D051379:Mice; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014346:Trypanosoma brucei brucei; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000517:prevention & control
D014344:Trypanocidal Agents; C003915:diminazene aceturate; D004133:Diminazene; D000518:Eflornithine