Role of atrial natriuretic factor in sodium and water retention in patients with schistosomal hepatic fibrosis.
Fifty subjects divided into three groups were studied: Group I: 10 normal adult subjects as controls. Group II: 20 patients with schistosomal hepatic fibrosis (SHF) without ascites (compensated stage). Group III: 20 patients with SHF with ascites. In all these patients plasma atrial natriuretic factor (ANF), serum aldosterone and serum osmolality were determined. There was a significant decrease in the plasma ANF in groups II and III compared to group I. There was a significant increase in the serum aldosterone level in group III compared to groups I and II. No significant difference was noted in serum sodium and potassium levels among the three groups. There was a significant decrease in serum osmolality in groups II and III compared to group I.
Habib
Y A
YA
Department of Physiology and Tropical Medicine, Faculty of Medicine, Alexandria, Egypt.
Kira
L H
LH
el-Sherbini
H A
HA
Asser
L A
LA
el-Shamy
E A
EA
Hatem
Y A
YA
D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000502:physiology*; D001834:Body Water / Q000378:metabolism*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism* / Q000469:parasitology; D008109:Liver Diseases, Parasitic / Q000150:complications / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012552:Schistosomiasis / Q000150:complications / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012964:Sodium