Effects of aldose reductase inhibitors on prostacyclin (PGI2) synthesis by aortic rings from rats with streptozotocin-induced diabetes.
The effects of aldose reductase inhibitors (ARIs) on the synthesis of prostacyclin (PGI2) by aortic rings from diabetic rats were examined. The ARIs studied were ONO-2235 and isoliquiritigenin, a new compound extracted from glycyrrhizae radix. The content of sorbitol in the sciatic nerve of diabetic rats induced by streptozotocin was significantly increased as compared with that of controls. This increase was significantly inhibited by the administration of an ARI. On the other hand, there was a marked decrease in the synthesis of PGI2 by the diabetic rats compared with the control rats. The decrease in PGI2 synthesis was significantly reversed by the administration of an ARI. Furthermore, the synthesis of PGI2 by the aortic rings was inversely correlated with the content of sorbitol in sciatic nerves. Those observations suggest that an ARI may have a beneficial effect on the vascular synthesis of PGI2 in diabetes mellitus.
Wakasugi
M
M
Third Department of Internal Medicine, University of Yamanashi Medical School, Japan.
Noguchi
T
T
Inoue
M
M
Tawata
M
M
Shindo
H
H
Onaya
T
T
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology; D047188:Chalcones; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003925:Diabetic Angiopathies / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012236:Rhodanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012584:Sciatic Nerve / Q000737:chemistry; D013012:Sorbitol / Q000032:analysis; D013311:Streptozocin; D013402:Sugar Alcohols / Q000378:metabolism*; D053778:Thiazolidines
D001786:Blood Glucose; D047188:Chalcones; D013402:Sugar Alcohols; D053778:Thiazolidines; C038131:epalrestat; D013012:Sorbitol; D002599:Chalcone; D013311:Streptozocin; D012236:Rhodanine; C040920:isoliquiritigenin; D011464:Epoprostenol; D000449:Aldehyde Reductase