[Therapy of mild to moderate hypertension. Efficacy and tolerance of Amlodipine in comparison with the combination nifedipine/mefruside].
Earlier clinical trials demonstrated the anti-hypertensive effect of amlodipine, a new calcium channel blocker of the dihydropyridine type. In the present comparative study, we investigated the anti-hypertensive effect of amlodipine in comparison with a combination of nifedipine and mefruside. In both groups, the anti-hypertensive effect was comparable. Normalization of the supine diastolic blood pressure was observed in 72.3% of patients treated with amlodipine and in 66.6% of those patients in the combination group. Both drugs were generally well tolerated, with a somewhat higher incidence of side effects being observed in the combination group. The study shows that amlodipine monotherapy in mild-to-moderate hypertension is equally as effective as combination therapy with nifedipine/mefruside, with amlodipine being superior in terms of tolerability.
Höfling
B
B
Medizinische Klinik I, Klinikum Grosshadern der Universität München.
Häringer
E
E
Herrmann
W
W
Pieske
H
H
Pieske
R
R
Philippi
M
M
D000328:Adult; D000368:Aged; D017311:Amlodipine; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008529:Mefruside / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D004338:Drug Combinations; D017311:Amlodipine; D009543:Nifedipine; D008529:Mefruside
Therapie der leichten bis mittelschweren Hypertonie. Wirksamkeit und Verträglichkeit von Amlodipin im Vergleich zur Fixkombination Nifedipin/Mefrusid.