Chemistry of colchicine.
Chemical structures of colchicine and related analogs, including allo-compounds with a six-membered ring, are presented here with correct absolute configurations, showing the natural representatives as a S-atropisomers. Spectral data, synthesis, biosynthesis, and metabolism of colchicine are discussed. Structural requirements required for these compounds to inhibit polymerization of tubulin and binding of radiolabeled colchicine in vitro are presented.
Muzaffar
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Natural Products Section, NIDDK, National Institutes of Health, Bethesda, MD 20892.
Brossi
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D000818:Animals; D003078:Colchicine / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans
D003078:Colchicine