[Treatment of gastric ulcer with sucralfate and famotidine].
We conducted a double blind random study on 79 patients with gastric ulcer: 39 received sucralfate, 1 g 4 times a day (Group 1) and 40 received a single evening dose of famotidine, 40 mg (Group 2). At 4 weeks, endoscopy revealed healing of the ulcer in 46% of patients in Group 1 and 40% in Group 2 (NS). At 8 weeks, corresponding figures were 90% and 75% (NS). All patients were able to complete treatment and minor side effects were reported from all patients, 36% with sucralfate and 28% with famotidine. Thus, sucralfate and famotidine are equally effective for therapy of gastric ulcer. The higher percentage of healing with sucralfate observed in this study was not statistically significant.
Hoffenberg
P
P
Departamento de Gastroenterología, Hospital San Juan de Dios, Santiago de Chile.
Reyes
V
V
Palma
J
J
Ossa
P
P
Maggiolo
P
P
Klinger
J
J
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D015738:Famotidine / Q000627:therapeutic use*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000188:drug therapy*; D013392:Sucralfate / Q000627:therapeutic use*
D013392:Sucralfate; D015738:Famotidine
Tratamiento de la úlcera gástrica con sucralfato y famotidina.