title: Growth of Tyzzer's organisms in preneoplastic hepatocytes of rats.
abstract: Tyzzer's disease in rats carrying preneoplastic or neoplastic lesions in the liver was studied histopathologically and immunohistochemically. The formation of necrotic foci and the growth of organisms were detected within both glutathione S-transferase placental type (GST-P) positive preneoplastic or neoplastic hepatocyte areas and GST-P negative areas. However, plasma glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) values and number of necrotic foci of infected animals having preneoplastic lesions in the liver were smaller than those of infected animals receiving no carcinogenic procedure. These results suggest that the environment consisted of preneoplastic hepatocytes was unsuitable for the growth of organisms as compared with that of intact hepatocytes though the organism could grow within the preneoplastic hepatocytes.
authors.affiliation: Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nii
authors.forename: K
authors.initials: K
authors.lastname: Fujiwara
authors.forename: N
authors.initials: N
authors.lastname: Goto
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D016863:Bacillaceae Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D001407:Bacillus / Q000254:growth & development*; D002478:Cells, Cultured; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis; D006520:Hepatitis, Animal / Q000382:microbiology* / Q000473:pathology; D007150:Immunohistochemistry; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008113:Liver Neoplasms / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011230:Precancerous Conditions / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase