Molecular diversity and function of G proteins and calcium channels.
General features of signal transduction by G proteins and structural properties of G-protein-modulated calcium channels are described. Recent results on roles of beta gamma dimers in signal transduction, on the kinetic properties of Gi alpha subunits and structural diversity of Go alpha subunits are discussed, as are the background and current state of our knowledge of the modulation of calcium channels by G proteins.
Birnbaumer
L
L
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030.
Perez-Reyes
E
E
Bertrand
P
P
Gudermann
T
T
Wei
X Y
XY
Kim
H
H
Castellano
A
A
Codina
J
J
D000595:Amino Acid Sequence; D000818:Animals; D015220:Calcium Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D012689:Sequence Homology, Nucleic Acid; D015398:Signal Transduction / Q000502:physiology
D015220:Calcium Channels; D019204:GTP-Binding Proteins