title: [Indomethacin in the treatment of acute cholecystitis and biliary colic].
abstract: Prostaglandins GE2 produces on the gallbladder a rise in intraluminal pressure, an increase in in intraluminal secretion, improves gallbladder contraction and decreases its absorption capacity. In this study, patients who received indomethacin twice a day by rectum, showed a significant reduction in volume and area of gallbladder after 24 and 48 hours (P < 0.05). The gallbladder volume after 24 hours had SEM 9.13 cm3, 95% CI 55.28 + 73.49 (P < 0.05). Score pain reduction after 24 hours was also significant (P < 0.001). The patients who underwent the classical Baralcina treatment of one IV vial BID showed a reduction in diameter and area of gallbladder but this was not statistically significant (P < 0.10). Reduction of volume at 24 hours was SEM 5.34 cm3 95% CI - 64.72 + 76.60 P 0.10 NS; and at 48 hours SEM 3.5 cm3, 95% CI 59.52% + 66.52 P 0.40. Score pain reduction was only significant at 48 hours P 0.001. The number of patients without pain at 24 hours was significantly higher in the indomethacin group ESP 0.21; 95% CI 0.46 + 0.88 P 0.001. In conclusion indomethacin is a useful medication in the treatment of acute cholecystitis and biliary colic due to its anti-prostaglandin effect on the gallbladder.
authors.affiliation: Unidad de Hepatología-Gastroenterología y Nutrición, Hospital Dr. Pedro Emilio Carrillo, Valera, Venezuela.
authors.forename: M S
authors.initials: MS
authors.lastname: Añez
authors.forename: D
authors.initials: D
authors.lastname: Martínez
authors.forename: J L
authors.initials: JL
authors.lastname: Pacheco
authors.forename: H
authors.initials: H
authors.lastname: González
authors.forename: J
authors.initials: J
authors.lastname: Rivera
authors.forename: E
authors.initials: E
authors.lastname: Pelaschier
authors.forename: L
authors.initials: L
authors.lastname: Uzcátegui
authors.forename: M D
authors.initials: MD
authors.lastname: Romero
authors.forename: Z
authors.initials: Z
authors.lastname: Molina
authors.forename: M
authors.initials: M
authors.lastname: Roditti de Montilla
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001577:Benzophenones / Q000627:therapeutic use; D002764:Cholecystitis / Q000188:drug therapy*; D003085:Colic / Q000188:drug therapy*; D004177:Dipyrone / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D005705:Gallbladder Diseases / Q000188:drug therapy*; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use; D013488:Suppositories
chemical_list: D001577:Benzophenones; D004338:Drug Combinations; D010880:Piperidines; D013488:Suppositories; D004177:Dipyrone; C002416:fenpiverinium bromide, pitofenone hydrochloride, dipyrone drug combination; D007213:Indomethacin
vernacular_title: Indometacina en el tratamiento de la colecistitis aguda y cólico biliar.