[Venous thrombosis of the lower limbs and pulmonary embolism after desmopressin: a coincidence or a pathogenetic role?].
The authors describe a case of venous thrombosis of the legs, complicated by pulmonary embolism, in a 71 year-old man, following desmopressin therapy for hypothalamic diabetes insipidus. They suggest a role of desmopressin in stimulating the release of Von Willebrand's factor (VWF) from endothelial cells. VWF facilitates platelet adhesion by forming a bridge between platelet membrane and vascular subendothelium, followed by development of a large thrombus.
Pentimone
F
F
Del Corso
L
L
D000368:Aged; D003894:Deamino Arginine Vasopressin / Q000009:adverse effects*; D003919:Diabetes Insipidus / Q000188:drug therapy; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000139:chemically induced*; D013924:Thrombophlebitis / Q000139:chemically induced*; D014841:von Willebrand Factor / Q000187:drug effects
D014841:von Willebrand Factor; D003894:Deamino Arginine Vasopressin
Trombosi venosa degli arti inferiori ed embolia polmonare dopo desmopressina: una coincidenza o un ruolo patogenetico?