[Necrotizing extracapillary glomerulonephritis without immunoglobulin deposits. Renal localization of systemic vasculitis with anti-cytoplasm polynuclear antibodies].
Necrotizing and crescentic glomerulonephritis without immunoglobulin deposits (also called pauci-immune glomerulonephritis) is the cause of approximately 50 percent of acute renal failures of glomerular origin. Our study, based on 40 case-records selected on histological criteria, and on data from the literature, shows that in most cases, if not all, this type of glomerulonephritis is part of a wider systemic vasculitis which predominantly affects the glomerular capillaries. Anti-neutrophil cytoplasm antibodies are detected in three-quarters of the cases, with a specific distribution that varies according to the clinical features. In spite of the patients' age (mean: 62 years), the severity of glomerular lesions and the extra-renal diffusion of the disease, 60 percent of these patients can be cured and recover a normal, or at least acceptable renal function, provided the corticosteroid and sometimes immunosuppressive therapy is initiated at an early stage.
Bindi
P
P
Service de Néphrologie, Hôpital Tenon, Paris.
Mougenot
B
B
Mentre
F
F
Noel
L H
LH
Peraldi
M N
MN
Vanhille
P
P
Lesavre
P
P
Mignon
F
F
Ronco
P
P
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis*; D003593:Cytoplasm / Q000276:immunology*; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007674:Kidney Diseases / Q000175:diagnosis / Q000188:drug therapy; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology* / Q000473:pathology; D011379:Prognosis; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*
D000305:Adrenal Cortex Hormones; D000906:Antibodies; D007166:Immunosuppressive Agents
Glomérulonéphrite extracapillaire nécrosante sans dépôts d'immunoglobuline. Localisation rénale d'une vasculite systémique avec anticorps anti-cytoplasme des polynucléaires.