Toxicological and toxicogenetic effects of plants used in popular medicine and in cattle food.
Toxicological and toxicogenetic effects of aqueous (tea) and hexanic fruit extract of Indigofera suffruticosa Mill. and hydroalcoholic root extract of Solanum agrarium Stendt. were evaluated in Balb C male mice intraperitoneally exposed. A hepatotoxic effect was observed just for animals treated with aqueous fruit extract of I. suffruticosa. In relation to the toxicogenetic effect, just the group treated with 12.5% of toxic dose of aqueous fruit extract of I. suffruticosa showed a statistically significant increase in the frequency of cells with chromosome aberrations (cytogenetic effect), although a slight increase was also observed for the highest dose (25% of LD50) of hydroalcoholic root extract of S. agrarium. The results obtained show that before S. agrarium is used as medicine and before the wide use of I. suffruticosa in cattle food, careful evaluation must be done.
Ribeiro
L R
LR
Laboratório de Genética Toxicológica, Escola de Medicina Veterinária, UFBA, Salvador, Brasil.
Bautista
A R
AR
Silva
A R
AR
Sales
L A
LA
Salvadori
D M
DM
Maia
P C
PC
D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D001938:Brazil; D002869:Chromosome Aberrations; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity; D010945:Plants, Edible; D010946:Plants, Medicinal; D010947:Plants, Toxic
D009153:Mutagens; D010936:Plant Extracts