title: Effects of amiodarone on the pharmacokinetics and toxicity of digoxin in laboratory animals.
abstract: Some pharmacokinetic interactions between digoxin and amiodarone were studied in experiments on rabbits. An increase of digoxin serum levels was established in amiodarone-treated rabbits (amiodarone 30 mg/kg s. c. for five days administered alone or together with digoxin). The calculated elimination half-life(t1/2) and the area under the curve (AUC) of digoxin were increased and the digoxin clearance was decreased, being most pronounced in animals receiving a combination of amiodarone and digoxin for five days. Changes were observed neither in the digoxin toxicity in amiodarone-treated guinea-pigs nor in the serum levels of T4, T3 and TTH. The possible mechanisms of the digoxin-amiodarone interactions are discussed.
authors.affiliation: Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
authors.forename: D
authors.initials: D
authors.lastname: Staneva-Stoytcheva
authors.forename: E
authors.initials: E
authors.lastname: Kristeva
mesh_terms: D000638:Amiodarone / Q000494:pharmacology*; D000818:Animals; D002682:Chinchilla; D003404:Creatinine / Q000097:blood; D004077:Digoxin / Q000493:pharmacokinetics* / Q000633:toxicity*; D006207:Half-Life; D007457:Iodine Radioisotopes; D008297:Male; D011817:Rabbits; D011863:Radioimmunoassay; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D004077:Digoxin; D013972:Thyrotropin; D003404:Creatinine; D000638:Amiodarone; D013974:Thyroxine