Simultaneous investigation of the rat serum and liver response in an acute toxic substances exposure.
Some biochemical parameters were simultaneously investigated in serum and hepatic homogenate in acute experiment with three pesticides in rat. The one-dose exposure response was relatively well correlated with the chemical toxicity and showed the statistically significant values, preferentially placed 48 hours after dosing. The liver morphological alteration might be associated with the serum and tissue comportment of the bioenzymological factors. The various genotoxicity induced by the three pesticides, appreciated by the frequency of micronucleus induction in the bone marrow cells, completes the data about the one-dose exposure effects of the chemical in rat.
Codorean
E
E
Victor Babeş Institute, Department of Pathology, Bucharest, Romania.
Filipescu
G
G
Tănase
C
C
Ciotaru
L
L
Mihalache
D
D
Laky
D
D
D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000032:analysis; D000252:Calcium-Transporting ATPases / Q000032:analysis; D005969:Glutamate Dehydrogenase / Q000096:biosynthesis; D007931:Leucyl Aminopeptidase / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D015162:Micronucleus Tests; D010575:Pesticides / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D010575:Pesticides; D005969:Glutamate Dehydrogenase; D007931:Leucyl Aminopeptidase; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases