The effect of aminoguanidine on the blood-retinal barrier in streptozocin-induced diabetic rats.
The effect of aminoguanidine hydrochloride (AG) on the blood-retinal barrier was studied in rats with streptozocin-induced diabetes. Half of the rats were given AG (100 mg/kg/day) while the remainder received no treatment. Vitreous fluorophotometry was performed on all rats before STZ injection and 2 weeks after induction of diabetes mellitus. Two weeks after STZ injection the mean 60-minute vitreous fluorescein concentration following dye injection had increased more in the nontreated group than in the AG-treated group, suggesting that AG may have some beneficial effect on the breakdown of the blood-retinal barrier.
Cho
H K
HK
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans 70112.
Kozu
H
H
Peyman
G A
GA
Parry
G J
GJ
Khoobehi
B
B
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001813:Blood-Retinal Barrier; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism*; D015590:Fluorophotometry; D006146:Guanidines / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin; D014822:Vitreous Body / Q000378:metabolism
D001786:Blood Glucose; D006146:Guanidines; D013311:Streptozocin; C004479:pimagedine