[Reparation of hepatocyte mitochondrial membranes using phosphatidylcholine liposomes].
The influence of multibilayer phosphatidylcholine liposomes on the properties of rat hepatocyte mitochondria membranes damages caused by hepatotropic toxin--CCl4 was investigated. Alterations of the membrane structure were estimated by the decrease in phospholipid/protein ratio /by 33%/ and via changes of quantitative and qualitative composition of phospholipid components. The possibility of reparation of the hepatocytes mitochondria damaged membrane by egg yolk phosphatidylcholine liposomes is shown. Phosphatidylcholine reparative effect on the damaged membranes is revealed in quantitative phospholipid fractions redistribution.
Dobrynina
O V
OV
Migushina
V L
VL
Shatinina
S Z
SZ
Kapitanov
A B
AB
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology; D004337:Drug Carriers; D008081:Liposomes; D008115:Liver Regeneration; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D004337:Drug Carriers; D008081:Liposomes; D010713:Phosphatidylcholines; D000251:Adenosine Triphosphatases
Reparatsiia mitokhondrial'nykh membran gepatotsitov s pomoshch'iu fosfatidilkholinovykh liposom.