title: The syndrome of ophthalmoplegia, ataxia and areflexia (Fisher's syndrome): clinical analysis of 9 cases.
abstract: From January 1976 through December 1988, 9 patients with clinical manifestations of the syndrome of ophthalmoplegia, ataxia and areflexia were diagnosed at National Taiwan University Hospital. Among them, 2 patients experienced recurrent attacks. A total of 12 attacks were recorded. Preceding symptoms of upper respiratory tract infection were noted in 9 out of 12 attacks. A spectrum of neuro-ophthalmological manifestations was observed. Most of these findings were probably secondary to central nervous system involvement. An elevation of protein level without pleocytosis was found in CSF examination of 6 attacks. Electrodiagnostic studies suggested large myelinated sensory fibers involvement as the major finding in 5 patients. A benign course in all 9 patients was noted. Special attention to nosological position and unusual features are also discussed.
authors.affiliation: Department of Neurology, National Taiwan University Hospital, Taipei, R.O.C.
authors.forename: P K
authors.initials: PK
authors.lastname: Yip
authors.forename: S Y
authors.initials: SY
authors.lastname: Tsai
authors.forename: R C
authors.initials: RC
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D001259:Ataxia / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D009886:Ophthalmoplegia / Q000503:physiopathology*; D011129:Polyradiculoneuropathy / Q000503:physiopathology*; D012018:Reflex; D013577:Syndrome