Skeletal muscle ultrastructural alterations in a case of Guillain-Barre syndrome.
The structural study of a muscle biopsy from a case of Guillain-Barré syndrome showed the typical findings of neurogenic atrophy and several abnormalities not commonly observed in denervated muscle as fibre necrosis, capillary alterations and infiltration of macrophages and occasional mast cells. The histopathological picture was similar to that found in the muscular compromise of some autoimmune diseases. The possibility for an immune mechanism in the muscle damage of Guillain-Barré syndrome is discussed.
Finol
H J
HJ
Centro de Microscopía Electrónica, Facultad de Ciencias, Universidad Central de Venezuela, Caracas.
Márquez
A
A
Montes de Oca
I
I
Müller
B
B
D000293:Adolescent; D001707:Biopsy, Needle; D002196:Capillaries / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D009132:Muscles / Q000098:blood supply / Q000648:ultrastructure*; D009133:Muscular Atrophy / Q000473:pathology; D009336:Necrosis; D011129:Polyradiculoneuropathy / Q000473:pathology*