title: [The diagnosis and treatment of lymphogranulomatosis in children].
abstract: Results of treatment of 124 pediatric patients with Hodgkin's disease with a follow-up period of not less than 5 years were analysed. The diagnostic workup included laparotomy. As a result, stage of disease was changed in 24 (28.5%) out of 84 operated patients. Treatment with CVPP combination chemotherapy (several cycles) and extended-field telegammatherapy yielded a five-year survival rate of 86.2% with 77.4% of patients being free from relapse. Splenectomy did not influence long-term results: five-year survival rates in operated and non-operated patients were 86.9 and 85%, respectively. No delayed toxicity associated with chemoradiation treatment was encountered.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Atamanov
authors.forename: A A
authors.initials: AA
authors.lastname: Malikov
authors.forename: N M
authors.initials: NM
authors.lastname: Golovkina
authors.forename: L A
authors.initials: LA
authors.lastname: Romantsova
authors.forename: N V
authors.initials: NV
authors.lastname: Silinskaia
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007813:Laparotomy; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D012008:Recurrence; D013156:Splenectomy; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D009588:Nitrogen Mustard Compounds; D011344:Procarbazine; D014750:Vincristine; D011239:Prednisolone
vernacular_title: Diagnostika i lechenie limfogranulematoza u deteĭ.