title: Chlorhexidine mouthwash-induced fixed drug eruption. Case report and review of the literature.
abstract: Various adverse reactions including anaphylactic shock have already been reported after the topical application of chlorhexidine. This article reports for the first time a hypersensitivity reaction in the form of fixed drug eruption after the use of a mouthwash containing chlorhexidine. This report should bring an increased awareness of the possibility of systemic hypersensitivity reaction to chlorhexidine in a previously sensitized person. The report also will add fixed drug eruption to the list of skin hypersensitivity reactions caused by chlorhexidine.
authors.affiliation: Department of Oral Diagnosis and Radiology, University of Missouri, Kansas City.
authors.forename: B K
authors.initials: BK
authors.lastname: Moghadam
authors.forename: C L
authors.initials: CL
authors.lastname: Drisko
authors.forename: R E
authors.initials: RE
authors.lastname: Gier
mesh_terms: D002710:Chlorhexidine / Q000009:adverse effects* / Q000031:analogs & derivatives; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005533:Foot Dermatoses / Q000209:etiology; D006229:Hand Dermatoses / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D009067:Mouthwashes / Q000009:adverse effects; D010919:Placebos
chemical_list: D009067:Mouthwashes; D010919:Placebos; C010882:chlorhexidine gluconate; D002710:Chlorhexidine