A cytochemical study of cerebrovascular lesions in mice infected with Plasmodium berghei.
Mice with a Plasmodium berghei infection exhibit morphological and cytochemical changes in the blood-brain barrier. Changes in activity and localization of alkaline phosphatase and adenosine triphosphatase, enzymes with important functions in the maintenance of the blood-brain barrier, were observed. Changes in activity and localization of those enzymes in and near the endothelial cells of the microvasculature, concomitant with an increase in pinocytotic activity, and formation of irregular cytoplasmic extensions in these cells, as well as loosening of the basal lamina are indicative of a functional deterioration of the blood-brain barrier in the course of infection.
Polder
T W
TW
Department of Neurosurgery, University Hospital Nijmegen, The Netherlands.
Eling
W M
WM
Jerusalem
C R
CR
Wijers-Rouw
M
M
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D001927:Brain Diseases / Q000201:enzymology / Q000473:pathology*; D002196:Capillaries / Q000201:enzymology / Q000473:pathology / Q000648:ultrastructure; D002462:Cell Membrane / Q000201:enzymology / Q000648:ultrastructure; D002560:Cerebrovascular Circulation; D004730:Endothelium, Vascular / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D008288:Malaria / Q000201:enzymology / Q000473:pathology*; D051379:Mice; D010962:Plasmodium berghei
D000469:Alkaline Phosphatase; D000251:Adenosine Triphosphatases