Somatic and behavioral ontogeny in three rat strains: preliminary observations of dopamine-mediated behaviors and brain D-1 receptors.
1. The acquisition of developmental milestones and maturational motor reflexes were compared in three rat strains (culled to 8 pups/litter), F344, Buff and SD. 2. Open field behavior on postnatal day 21 was scored for locomotor activity, rears and center entries. 3. F344 rats, which model ADHD, were the slowest of the three strains in acquiring a number of developmental milestones and in gaining weight; but they were intermediate in their scores for locomotor activity and rearing during open field testing at postnatal day 21. 4. Preliminary autoradiographic data using the D-1 specific ligand [3H]SCH 23390 are included which suggest that D-1 receptors, which display age-dependent changes in concentration and distribution, are relevant to day 21 open field behavior. 5. F344 rats demonstrate developmental "dysmaturation" which is consistent with that observed in children with ADHD in that somatic growth is disproportionately delayed in comparison to neurological and motor maturation.
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Department of Psychiatry, University of Washington, Seattle.
Petracca
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F
Diaz
J
J
D000818:Animals; D001345:Autoradiography; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000254:growth & development*; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006128:Growth / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D011915:Rats, Inbred BUF; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*; D017447:Receptors, Dopamine D1; D012018:Reflex / Q000502:physiology; D013045:Species Specificity
D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D004298:Dopamine