Eicosanoid synthesis in murine macrophages can be shifted from prostaglandins to leukotrienes but not vice versa by specific inhibitors of cyclooxygenase or 5'-lipoxygenase activity.
Kaever
V
V
Institute of Molecular Pharmacology, Medical School Hannover, Federal Republic of Germany.
Resch
K
K
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors; D015232:Dinoprostone / Q000096:biosynthesis; D004789:Enzyme Activation / Q000187:drug effects; D007211:Indoles / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D015289:Leukotrienes / Q000096:biosynthesis*; D016859:Lipoxygenase Inhibitors; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008811:Mice, Inbred DBA; D011453:Prostaglandins / Q000096:biosynthesis*; D011493:Protein Kinase C / Q000378:metabolism; D013189:SRS-A / Q000096:biosynthesis; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology; D002722:Chlorobenzenes
D000001:Calcimycin; D002118:Calcium; D016861:Cyclooxygenase Inhibitors; D015232:Dinoprostone; D007211:Indoles; D007213:Indomethacin; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D011453:Prostaglandins; D011493:Protein Kinase C; D013189:SRS-A; D013755:Tetradecanoylphorbol Acetate; D015054:Zymosan; C060893:MK-886; D002722:Chlorobenzenes