Consumption of prunes as a source of dietary fiber in men with mild hypercholesterolemia.
Forty-one free-living adult men with mild hypercholesterolemia (5.2-7.5 mmol/L) voluntarily participated in an 8-wk crossover study designed to determine the effect of prunes as a source of fiber on plasma cholesterol and on fecal output and bile acid concentration. During the prune period, subjects supplemented their usual diets with 12 prunes (100 g; 6 g dietary fiber) daily. Plasma low-density-lipoprotein cholesterol was significantly lower after the prune period (3.9 mmol/L) than after the grape-juice-control period (4.1 mmol/L). Fecal bile acid concentration of lithocholic acid was significantly lower after the prune period (0.95 mg bile acid/g dry wt stool) than after the grape-juice-control period (1.20 mg bile acid/g dry wt stool). Both fecal wet and dry weights were approximately 20% higher after the prune period than after the grape-juice-control period. Total bile acids (mg/72 h) did not significantly differ between experimental periods.
Tinker
L F
LF
Department of Nutrition, University of California, Davis 95616.
Schneeman
B O
BO
Davis
P A
PA
Gallaher
D D
DD
Waggoner
C R
CR
D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000032:analysis; D008078:Cholesterol, LDL / Q000097:blood; D003672:Defecation; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004043:Dietary Fiber / Q000627:therapeutic use*; D005243:Feces / Q000737:chemistry; D005638:Fruit; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010368:Pectins / Q000627:therapeutic use
D001647:Bile Acids and Salts; D008078:Cholesterol, LDL; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004043:Dietary Fiber; D008055:Lipids; D010368:Pectins