Resolution of microsporidial epithelial keratopathy in a patient with AIDS.
A patient with a positive human immunodeficiency virus (HIV) titer and cryptococcal meningitis suffered bilateral epithelial keratopathy caused by Encephalitozoon, which did not respond to sulfas, erythromycin, bacitracin, tobramycin, neomycin, polymyxin B, or fluconazole. Eventual administration of itraconazole for the meningitis apparently produced resolution of the long-lasting (2-month) ocular infection. This new oral triazole antifungal may be valuable against the increasingly prevalent microsporidial infections in patients with acquired immune deficiency syndrome. Debulking of the infection by corneal scraping may have contributed to the authors' success.
Yee
R W
RW
Department of Ophthalmology, University of Texas Health Science Center, San Antonio 78284.
Tio
F O
FO
Martinez
J A
JA
Held
K S
KS
Shadduck
J A
JA
Didier
E S
ES
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000188:drug therapy* / Q000469:parasitology; D003453:Cryptococcosis / Q000188:drug therapy; D009670:Encephalitozoon cuniculi / Q000187:drug effects / Q000648:ultrastructure; D015822:Eye Infections, Parasitic / Q000188:drug therapy*; D006679:HIV Seropositivity; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008581:Meningitis / Q000188:drug therapy; D009894:Opportunistic Infections / Q000188:drug therapy*; D011528:Protozoan Infections / Q000188:drug therapy*
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole