title: Anti-thyroid antibodies in patients with hyperprolactinemia.
abstract: To clarify the possible role of prolactin in the regulation of immune responses in man, we measured circulating anti-thyroid antibodies in 172 normal subjects, 84 patients with prolactinoma and 63 patients with acromegaly with normal thyroid and adrenocortical functions. Frequencies of positive thyroidal microsome and thyroglobulin antibodies were significantly (p < 0.05 and p < 0.01, respectively) higher in women with prolactinoma (20.6% and 20.6%) than in normal women (7.5% and 4.7%). Men with prolactinoma had a significantly (p < 0.05) higher frequency of positive thyroglobulin antibody (18.8%) than normal men (1.5%). When the subjects were divided by decade, women with prolactinoma in the 4th decade had significantly (p < 0.05) higher frequencies of positive thyroidal microsome and thyroglobulin antibodies (30.8% and 30.8%) than normal women of corresponding age (3.7% and 3.7%). In contrast, there was no significant difference in the frequencies of positive anti-thyroid antibodies in patients with acromegaly and in normal subjects. Analysis of the peripheral lymphocyte population revealed that patients with prolactinoma had a higher percentage of B cells than normal subjects, while there was no significant difference in the percentages of total T lymphocytes or in the helper and suppressor T cell ratios in the two groups of subjects. These results suggest that prolactin regulates humoral immune responses in man directly by stimulating B lymphocytes or indirectly by inhibiting suppressor T lymphocyte activity.
authors.affiliation: Fourth Department of Medicine, Teikyo University School of Medicine, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ishibashi
authors.forename: N
authors.initials: N
authors.lastname: Kuzuya
authors.forename: S
authors.initials: S
authors.lastname: Sawada
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: K
authors.initials: K
authors.lastname: Kamoi
authors.forename: T
authors.initials: T
authors.lastname: Yamaji
mesh_terms: D000172:Acromegaly / Q000276:immunology / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000917:Antibody Formation; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000276:immunology* / Q000473:pathology; D007111:Immunity, Cellular; D007518:Isoantibodies / Q000097:blood*; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000276:immunology / Q000473:pathology; D011388:Prolactin / Q000502:physiology; D015175:Prolactinoma / Q000276:immunology / Q000473:pathology; D012737:Sex Factors; D013961:Thyroid Gland / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007518:Isoantibodies; C035678:anti-Thy antibody; C006606:anti-thyroglobulin; C056626:thyroid microsomal antibodies; D011388:Prolactin