Evaluation of local renal function in newborn infants under tobramycin therapy.
Aminoglycosides (AG) provided for less than 5 days to newborn infants do not produce a marked disturbance of glomerular filtration rate (creatinine clearance) or tubular sodium handling (fractional sodium excretion). However, transient disturbances of proximal tubular cell functions can be noted: the excretion of N-acetylglucosaminidase, a lysosomal enzyme, is elevated, and mature not premature infants show a decreased tubular reabsorption of low-molecular-weight proteins during AG treatment. Preliminary investigations show an increased excretion of villin, a structural protein of proximal tubular cells, and a decreased secretion of Tamm-Horsfall protein by the cells of ascending limb of Henle and early distal tubule.
Leititis
J U
JU
Kinderklinik Albert-Ludwigs-Universität, Freiburg, FRG.
Zimmerhackl
L B
LB
Burghard
R
R
Gordjani
N
N
Brandis
M
M
D000617:Aminoglycosides / Q000627:therapeutic use; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D009399:Nephrons / Q000187:drug effects / Q000502:physiology; D014031:Tobramycin / Q000627:therapeutic use*
D000617:Aminoglycosides; D014031:Tobramycin