title: Systemic mast cell disease associated with primary mediastinal germ cell tumor.
abstract: The first known case of systemic mast cell disease associated with a germ cell tumor is reported. Six months after the complete remission of a primary mediastinal germ cell tumor treated by chemotherapy and resection, a young man had a series of episodes of hypotension and syncope and, a few months later, a gastric hemorrhage and coagulation disorder. The diagnosis of systemic mast cell disease was made in view of bone marrow and liver biopsies. A transient circulating heparin-like anticoagulant was noted. The occurrence in a short period of these two unusual conditions, given previous knowledge of hematologic disorders associated with germ cell tumors, suggests that the present association is not a coincidence. Systemic mast cell disease should be considered among the hematologic disorders associated with a germ cell tumor.
authors.affiliation: Department of Pneumology, Centre Hospitalier Intercommunal de Créteil, France.
authors.forename: P
authors.initials: P
authors.lastname: Chariot
authors.forename: I
authors.initials: I
authors.lastname: Monnet
authors.forename: F
authors.initials: F
authors.lastname: LeLong
authors.forename: C
authors.initials: C
authors.lastname: Chleq
authors.forename: J P
authors.initials: JP
authors.lastname: Droz
authors.forename: H
authors.initials: H
authors.lastname: de Cremoux
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008415:Mastocytosis / Q000150:complications*; D008479:Mediastinal Neoplasms / Q000150:complications*; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications*