title: [Structural-functional state of the hypertensive heart and atrial natriuretic factor during treatment with nifedipine].
abstract: The time course of structural and functional parameters using echocardiography and the level of atrial natriuretic factor (ANF) employing immunoradiometric assay were examined in 37 patients with essential hypertension taking a 3-week therapy with nifedipine (corinfar) in doses individually chosen. The changes in the structural and functional parameters of the hypertensive heart were found to be associated with its endocrine function. A course therapy of patients with essential hypertension with nifedipine in individually based doses caused a significant rise in plasma ANF levels, a normalization of cardiac compensatory mechanism function. The findings may be a basis for studying the new mechanisms of calcium antagonist action.
authors.forename: V A
authors.initials: VA
authors.lastname: Bobrov
authors.forename: V G
authors.initials: VG
authors.lastname: Shershnev
authors.forename: S N
authors.initials: SN
authors.lastname: Polivoda
authors.forename: S N
authors.initials: SN
authors.lastname: Konoshevich
mesh_terms: D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004452:Echocardiography; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D009320:Atrial Natriuretic Factor; D009543:Nifedipine
vernacular_title: Strukturno-funktsional'noe sostoianie gipertenzivnogo serdtsa i predserdnyĭ natriĭureticheskiĭ faktor pri lechenii nifedipinom.