[Severe vasculitis in cryoglobulinemia--mechanisms of Fc gamma receptor activation of granulocytes].
Monoclonal IgG-cryoglobulins activate PMN through Fc gamma-receptors. The expression of Fc gamma RII and Fc gamma RIII is decreased, the expression of Fc gamma RI, CD66 and CD67 is increased. During this activation substances like superoxide anions and lysosomal enzymes subsequently damaging the endothelium are released.
Hundt
M
M
Abteilung Klinische Immunologie und Transfusionsmedizin, Medizinische Hochschule Hannover.
Zielinska-Skowronek
M
M
Schmidt
R E
RE
D000328:Adult; D015703:Antigens, CD / Q000276:immunology; D000943:Antigens, Differentiation / Q000276:immunology*; D003449:Cryoglobulinemia / Q000150:complications*; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology*; D017452:Receptors, IgG; D014657:Vasculitis / Q000209:etiology*
D015703:Antigens, CD; D000943:Antigens, Differentiation; D011961:Receptors, Fc; D017452:Receptors, IgG
Schwere Vaskulitis bei Kryoglobulinämie--Mechanismen der Fc gamma-Rezeptor-Aktivierung von Granulozyten.