title: Catecholamines and blood glucose control in type 1 diabetes.
abstract: To evaluate the influence of blood glucose control on serum catecholamine levels (which reflect both plasma and platelet levels), six healthy non-diabetic subjects, seven well-controlled Type 1 diabetic patients, and six poorly controlled Type 1 diabetic patients were studied before (baseline) and after standardized exercise. A significant correlation was found between serum noradrenaline and HbA1 at baseline (r = 0.53, p less than 0.025) and after exercise (r = 0.71, p less than 0.001). Similar results were found for serum adrenaline (r = 0.68, p less than 0.005 and r = 0.61, p less than 0.005, respectively) and consequently total serum catecholamine content (r = 0.65, p less than 0.005 and r = 0.75, p less than 0.001, respectively). However, no relationship was found between serum catecholamine levels and actual blood glucose levels, age, body mass index or insulin dose. A moderate correlation was found between systolic blood pressure and serum levels of noradrenaline and total catecholamines after exercise (r = 0.48 and r = 0.48, both p less than 0.025).
authors.affiliation: Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Bilo
authors.forename: R O
authors.initials: RO
authors.lastname: Gans
authors.forename: M B
authors.initials: MB
authors.lastname: Polee
authors.forename: J
authors.initials: J
authors.lastname: van der Maten
authors.forename: C
authors.initials: C
authors.lastname: Popp-Snijders
authors.forename: A J
authors.initials: AJ
authors.lastname: Donker
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006339:Heart Rate; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D005082:Physical Exertion; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D004837:Epinephrine; D006442:Glycated Hemoglobin; D009638:Norepinephrine