title: [Therapy of mild to moderate hypertension. Efficacy and tolerance of Amlodipine in comparison with the combination nifedipine/mefruside].
abstract: Earlier clinical trials demonstrated the anti-hypertensive effect of amlodipine, a new calcium channel blocker of the dihydropyridine type. In the present comparative study, we investigated the anti-hypertensive effect of amlodipine in comparison with a combination of nifedipine and mefruside. In both groups, the anti-hypertensive effect was comparable. Normalization of the supine diastolic blood pressure was observed in 72.3% of patients treated with amlodipine and in 66.6% of those patients in the combination group. Both drugs were generally well tolerated, with a somewhat higher incidence of side effects being observed in the combination group. The study shows that amlodipine monotherapy in mild-to-moderate hypertension is equally as effective as combination therapy with nifedipine/mefruside, with amlodipine being superior in terms of tolerability.
authors.affiliation: Medizinische Klinik I, Klinikum Grosshadern der Universität München.
authors.forename: B
authors.initials: B
authors.lastname: Höfling
authors.forename: E
authors.initials: E
authors.lastname: Häringer
authors.forename: W
authors.initials: W
authors.lastname: Herrmann
authors.forename: H
authors.initials: H
authors.lastname: Pieske
authors.forename: R
authors.initials: R
authors.lastname: Pieske
authors.forename: M
authors.initials: M
authors.lastname: Philippi
mesh_terms: D000328:Adult; D000368:Aged; D017311:Amlodipine; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008529:Mefruside / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D002121:Calcium Channel Blockers; D004338:Drug Combinations; D017311:Amlodipine; D009543:Nifedipine; D008529:Mefruside
vernacular_title: Therapie der leichten bis mittelschweren Hypertonie. Wirksamkeit und Verträglichkeit von Amlodipin im Vergleich zur Fixkombination Nifedipin/Mefrusid.