title: Preserved atrial natriuretic peptide secretory function after cardiac transplantation.
abstract: The purpose of this investigation was to determine whether atrial natriuretic peptide (ANP) secretory function is preserved after cardiac transplantation. Thirteen hemodynamically stable outpatients performed supine exercise on a bicycle an average of 7 months after orthotopic cardiac transplantation. Right atrial pressure increased 2.2-fold (6 +/- 1 to 13 +/- 2 mm Hg) and pulmonary artery wedge pressure 2.1-fold (11 +/- 1 to 23 +/- 7 mm Hg) with exercise in the transplant recipients. Resting venous ANP level (114 +/- 19 pg/ml) and peak exercise venous level (373 +/- 61 pg/ml) was elevated in transplant recipients (p less than 0.001) compared with control subjects (21 +/- 1 and 92 +/- 14 pg/ml, respectively. This represents a 3.3-fold (114 +/- 19 to 373 +/- 61 pg/ml) increase in the ANP level from resting to exercise in transplant recipients and a 4.4-fold (21 +/- 1 to 92 +/- 14 pg/ml) increase in control subjects. A correlation between venous ANP levels and hemodynamics (right atrial pressure) was observed r = 0.49 p = 0.01. It is concluded that ANP levels at rest are elevated after cardiac transplant, the levels correlate with the intracardiac hemodynamics, and exercise-induced augmentation of plasma levels occurs.
authors.affiliation: Department of Internal Medicine, Ohio State University, Columbus.
authors.forename: R C
authors.initials: RC
authors.lastname: Starling
authors.forename: T M
authors.initials: TM
authors.lastname: O'Dorisio
authors.forename: W B
authors.initials: WB
authors.lastname: Malarkey
authors.forename: K D
authors.initials: KD
authors.lastname: Murray
authors.forename: P D
authors.initials: PD
authors.lastname: Myerowitz
authors.forename: R J
authors.initials: RJ
authors.lastname: Cody
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000503:physiopathology; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011312:Pressure; D011669:Pulmonary Wedge Pressure
chemical_list: D009320:Atrial Natriuretic Factor