title: The role of diacylglycerol/protein kinase C signaling in insulin-stimulated glucose transport.
abstract: There seems to be little doubt that insulin rapidly perturbs phospholipid metabolism, and this appears to increase DAG/PKC signaling in many target tissues. Considerable new evidence further suggests that DAG/PKC signaling plays an important role in insulin-stimulated glucose transport. Further studies are needed to test this hypothesis and examine its importance in states of clinical insulin resistance.
authors.affiliation: Research Service, J.A. Haley Veterans' Hospital, Tampa, FL.
authors.forename: R V
authors.initials: RV
authors.lastname: Farese
authors.forename: M L
authors.initials: ML
authors.lastname: Standaert
authors.forename: T
authors.initials: T
authors.lastname: Ishizuka
authors.forename: B
authors.initials: B
authors.lastname: Yu
authors.forename: T P
authors.initials: TP
authors.lastname: Arnold
authors.forename: D R
authors.initials: DR
authors.lastname: Cooper
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D004075:Diglycerides / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D004075:Diglycerides; D007328:Insulin; D010743:Phospholipids; D011493:Protein Kinase C; D005947:Glucose