Immunological status in Huntington's disease.
The immunological status of patients with Huntington's disease was studied and compared with that of an age-matched control group. No remarkable abnormalities in lymphocyte subpopulations were observed. The percentage of B cells, CD4+, CD8+, DR+ cells and stimulated cells bearing Tac receptors remained unchanged. The proliferative response to mitogens and the production of interleukin-1 (Il-1) were decreased, whereas the IgG level was increased. It is possible that changes in the levels of neurotransmitters affect the immunological function in basal ganglia disease.
Fiszer
U
U
Department of Cerebrovascular Disease, Institute of Psychiatry and Neurology, Warsaw, Poland.
Piotrowska
K
K
Korlak
J
J
Członkowska
A
A
D000328:Adult; D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007375:Interleukin-1