T cells, IgE antibodies, cytokines and allergic inflammation.
T helper cell (Th) subsets producing interleukin 4 (IL-4) or gamma interferon (IFN) play a reciprocal role in the regulation of human IgE synthesis. Though necessary, IL-4 alone was insufficient. Patients with hyper-IgE had significantly lower proportions of T-cells that produce IFN and TNF, but not IL-2 or IL-4. In patients with helminth infections or atopy production of IgE and eosinophilia may result from expansion of Th-2-like cells. T cell clones (TCC) specific for allergens and Toxocara canis (TES) showed dichotomy in cytokine secretion. Non-atopic donors gave insufficient TCC for comparison. Activation of the fibroblasts of the respiratory mucosae induces production of interstitial proteins such as collagen III, V, fibronectin.
Del Prete
G
G
Istituto di Clinica Medica III, University of florence, Italy.
Ricci
M
M
Romagnani
S
S
D000403:Airway Resistance; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology*; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000502:physiology*; D007249:Inflammation / Q000276:immunology*; D015847:Interleukin-4 / Q000096:biosynthesis; D008407:Mast Cells / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D016207:Cytokines; D015847:Interleukin-4; D007073:Immunoglobulin E