[The role of the mono-oxygenase system in realizing the biological effects of cisplatin].
The toxic and antitumor effects of cisplatin were shown to depend upon the activity of microsomal oxidation system enzymes. Administration of the drug in combination with K-2-9 enterosorbent was followed by an increase in its antitumor effect and amelioration of toxicity.
Chekhun
V F
VF
Pel'kis
F P
FP
Kulik
G I
GI
D000818:Animals; D002945:Cisplatin / Q000627:therapeutic use / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D016061:Enterosorption; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000201:enzymology; D010105:Oxygenases / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D010105:Oxygenases; D002945:Cisplatin
Rol' sistemy monooksigenaz v realizatsii biologicheskikh éffektov tsisplatina.