title: Speed of onset of action of the newer antidepressants--fluoxetine and bupropion.
abstract: The authors review 24 double-blind placebo-controlled studies comparing fluoxetine or bupropion against previously available antidepressants, to assess where there is evidence for a difference in the speed of onset of antidepressant action. Critical comparison of the studies showed no difference in speed of onset of action between these newer agents and conventional antidepressants.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425.
authors.forename: M S
authors.initials: MS
authors.lastname: George
authors.forename: R B
authors.initials: RB
authors.lastname: Lydiard
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D016642:Bupropion / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D015201:Meta-Analysis as Topic; D011569:Psychiatric Status Rating Scales
chemical_list: D000928:Antidepressive Agents; D005473:Fluoxetine; D016642:Bupropion