title: [A mutant strain of Drosophila simulans sensitive to the toxic and mutagenic action of benz(a)pyrene].
abstract: A 364 yv strain sensitive to the toxic effect of benzo(a)pyrene (BP) was identified among 49 mutant strains of Drosophila simulans. Heterozygotes female 364 x male Turku obtained by crossing 364 yv species with those of wild BP-resistant Turku strain were more sensitive than female Turku x male 364 heterozygotes to both toxic and mutagenic effects of the carcinogen in the test of induction of somatic mosaicism with the yellow marker. Non-carcinogenic pyrene appeared weekly toxic and non-mutagenic. Possible mechanisms of 364 yv strain sensitivity to BP as well as vistas in application of the strain for monitoring genotoxic environmental pollution are discussed.
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Fuks
authors.forename: R D
authors.initials: RD
authors.lastname: Safaev
authors.forename: E M
authors.initials: EM
authors.lastname: Khovanova
authors.forename: E G
authors.initials: EG
authors.lastname: Ugnivenko
authors.forename: G A
authors.initials: GA
authors.lastname: Belitskiĭ
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D003434:Crossing Over, Genetic / Q000187:drug effects / Q000235:genetics; D004330:Drosophila / Q000187:drug effects* / Q000235:genetics; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics; D005260:Female; D006579:Heterozygote; D008297:Male; D009030:Mosaicism / Q000235:genetics; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects*; D011721:Pyrenes / Q000633:toxicity
chemical_list: D009153:Mutagens; D011721:Pyrenes; D001564:Benzo(a)pyrene; C030984:pyrene
vernacular_title: Mutantnaia liniia Drosophila simulans, chuvstvitel'naia k toksicheskomu i mutagennomu deĭstviiu benz(a)pirena.