title: Influence of the selective cholecystokinin antagonist L-364,718 on pain threshold and morphine analgesia.
abstract: The intracerebroventricular injection of the cholecystokinin-A receptor antagonist L-364,718, at the doses of 0.5, 5, 10 or 20 micrograms/mouse, while having no effect on pain threshold (hot plate, 51 degrees C), antagonized the analgesic activity of morphine (10 mg/kg i.p.). This effect was obtained with a dose of 10 micrograms/mouse and was associated with a reduction of brainstem opiate-binding sites.
authors.affiliation: Institute of Pharmacology, University of Modena, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Poggioli
authors.forename: A V
authors.initials: AV
authors.lastname: Vergoni
authors.forename: M
authors.initials: M
authors.lastname: Sandrini
authors.forename: L
authors.initials: L
authors.lastname: Barbafiera
authors.forename: D
authors.initials: D
authors.lastname: Marrama
authors.forename: A
authors.initials: A
authors.lastname: Bertolini
mesh_terms: D000698:Analgesia; D000818:Animals; D001570:Benzodiazepinones / Q000378:metabolism / Q000494:pharmacology*; D001933:Brain Stem / Q000378:metabolism; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D020109:Devazepide; D005260:Female; D008297:Male; D051379:Mice; D009020:Morphine; D010146:Pain / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors; D012684:Sensory Thresholds
chemical_list: D001570:Benzodiazepinones; D011949:Receptors, Cholecystokinin; D009020:Morphine; D002766:Cholecystokinin; D020109:Devazepide