title: Hormonal and local factors in hypertension.
abstract: The cause of primary (essential) hypertension remains unknown, but a number of circulating hormones and endothelium-derived factors are probably involved. This review summarizes recent evidence on the roles of hyperinsulinemia, the renin-angiotensin system, atrial natriuretic factor, and three endothelium-derived factors--prostacyclin, endothelium-derived relaxing factor, and endothelin.
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8899.
authors.forename: N M
authors.initials: NM
authors.lastname: Kaplan
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology; D011464:Epoprostenol / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D006801:Humans; D006946:Hyperinsulinism / Q000503:physiopathology; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007333:Insulin Resistance; D008954:Models, Biological; D009132:Muscles / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology; D012084:Renin-Angiotensin System
chemical_list: D006728:Hormones; D009569:Nitric Oxide; D009320:Atrial Natriuretic Factor; D011464:Epoprostenol