title: Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.
abstract: Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.
authors.affiliation: Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Acha-Orbea
authors.forename: A N
authors.initials: AN
authors.lastname: Shakhov
authors.forename: L
authors.initials: L
authors.lastname: Scarpellino
authors.forename: E
authors.initials: E
authors.lastname: Kolb
authors.forename: V
authors.initials: V
authors.lastname: Müller
authors.forename: A
authors.initials: A
authors.lastname: Vessaz-Shaw
authors.forename: R
authors.initials: R
authors.lastname: Fuchs
authors.forename: K
authors.initials: K
authors.lastname: Blöchlinger
authors.forename: P
authors.initials: P
authors.lastname: Rollini
authors.forename: J
authors.initials: J
authors.lastname: Billotte
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002872:Chromosome Deletion; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005814:Genes, Viral; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010641:Phenotype; D011533:Proviruses / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D011948:Receptors, Antigen, T-Cell