Immunitary system in pregnancy hypertension.
Several Authors demonstrate changes in maternal immune system in women with pregnancy induced hypertension (PIH). In this study peripheral mononuclear cells were isolated in fifteen primigravid women with PIH and tested with monoclonal antibodies Leu 4, Leu 3, Leu 2 and Leu 7; in four women were studied monoclonal antibodies anti-Tac. The results were compared with a normotensive pregnant control group. T helper and T suppressor were increased but showed no statistical difference. The difference was statistically significant only for th NK cells. Tac antigen was expressed only on the Leu 3 induce subset. The PIH occurs because of a failure of maternal immune system.
Garzetti
G G
GG
Department of Obstetrics and Gynaecology, University of Ancona.
Cignitti
M
M
Ciavattini
A
A
Marchegiani
F
F
Romanini
C
C
Fabris
N
N
La Cava
M C
MC
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000276:immunology*; D007694:Killer Cells, Natural; D007958:Leukocyte Count; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000276:immunology*; D011263:Pregnancy Trimester, Third; D006377:T-Lymphocytes, Helper-Inducer
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation