Some extracellular matrix elements as markers of 'capillary tunnels' in hypertrophied rat heart.
We studied the distribution of the extracellular matrix proteins fibronectin (FN) and laminin (LM) in the hypertrophied hearts of spontaneously hypertensive rats (SHR), using an immunofluorescence method with specific antibodies. The immunohistochemical reaction was positive in the cytoplasm of some hypertrophied cardiomyocytes. The results showed that FN and LM can be used as markers for tunnels, i.e. intracardiocytic invaginations of the sarcolemma. The tunnels observed contained capillaries.
Ratajska
A
A
Department of Pathological Anatomy, Medical Academy of Warsaw, Poland.
Gawlik
Z
Z
Fiejka
E
E
D000818:Animals; D015415:Biomarkers; D002196:Capillaries / Q000737:chemistry* / Q000648:ultrastructure; D006332:Cardiomegaly / Q000473:pathology*; D016326:Extracellular Matrix Proteins / Q000737:chemistry* / Q000648:ultrastructure; D005353:Fibronectins / Q000648:ultrastructure; D007797:Laminin / Q000648:ultrastructure; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D015415:Biomarkers; D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D007797:Laminin