Prolonged action of enoximone in renal failure.
Enoximone was administered on two separate occasions to a 37-year-old woman with renal failure secondary to thrombotic thrombocytopenic purpura. Plasma concentrations of enoximone and its principal metabolite, enoximone sulphoxide, were measured over a 9-day period. As renal function improved the rate of elimination of enoximone sulphoxide increased. The duration of effect of enoximone may be prolonged in patients with renal failure.
Burns
A M
AM
John Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge.
Park
G R
GR
D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism*; D000328:Adult; D017335:Enoximone; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D011644:Puerperal Disorders; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications; D013997:Time Factors
D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D017335:Enoximone