Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping.
The genomic locus of the murine ST2 gene was isolated based on homology with a murine ST2 complementary DNA sequence and its complete nucleotide sequence was determined. The locus is composed of eight exons and seven introns and is approx. 9 kilobase pairs in size. Two Sp1 binding sites are present in the 5' flanking region. The murine ST2 gene, which was expressed only in the growth-stimulated BALB/c-3T3 cells, was mapped to mouse chromosome one, very tightly linked to the interleukin 1 receptor-type 1 locus.
Tominaga
S
S
Department of Biochemistry II, Jichi Medical School, Tochigi, Japan.
Jenkins
N A
NA
Gilbert
D J
DJ
Copeland
N G
NG
Tetsuka
T
T
D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002460:Cell Line; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D003433:Crosses, Genetic; D005091:Exons / Q000235:genetics; D005803:Genes, Immunoglobulin; D007438:Introns / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D017472:Receptors, Interleukin-1; D012689:Sequence Homology, Nucleic Acid
D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1