Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily.
Pro-platelet basic protein (pro-PBP) is the precursor of the two platelet alpha-granule proteins, PBP and connective tissue activating peptide-III. Upon platelet activations they are released and further processed in plasma to beta-thromboglobulin and neutrophil-activating peptide-2. The gene encoding pro-PBP is mapped in this study to chromosome 4q12-q13. At least four other members of this family of small inducible cytokines, including NAP-1/Il-8 and platelet factor 4, reside within the same locus, indicating a gene cluster for the beta-thromboglobulin family.
Wenger
R H
RH
Theodor-Kocher-Institut der Universität, Bern, Switzerland.
Hameister
H
H
Clemetson
K J
KJ
D018925:Chemokines; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D010455:Peptides / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D001620:beta-Thromboglobulin / Q000235:genetics*
D018925:Chemokines; C061615:PPBP protein, human; D010455:Peptides; D011506:Proteins; D001620:beta-Thromboglobulin; C009862:connective tissue-activating peptide