[Activation of polymorphonuclear neutrophils by contact with collagen I and degradation of collagen].
The contact of polymorphonuclear neutrophils with type I collagen molecules triggers the production of oxygen free radicals by these cells. This activation requires two short collagenic sequences and seems to involve a beta 2 integrin on the neutrophil membrane. Oxygen free radicals are capable to degrade collagen molecules into small peptides. This interaction takes place in inflammatory phenomena.
Monboisse
J C
JC
Laboratoire de Biochimie, CNRS URA 610, UFR Médecine, Université de Reims Champagne-Ardenne.
Garnotel
R
R
Bellon
G
G
Borel
J P
JP
D003094:Collagen / Q000378:metabolism* / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D016023:Integrins / Q000032:analysis / Q000378:metabolism; D009504:Neutrophils / Q000737:chemistry / Q000378:metabolism*; D010100:Oxygen / Q000494:pharmacology
D016023:Integrins; D003094:Collagen; D010100:Oxygen
Activation des polynucléaires neutrophiles par contact avec le collagène I et dégradation du collagène.