title: [Evaluation of rearrangement of immunoglobulin genes and T cell receptors in determining low numbers of leukemic in children with acute lymphoblastic leukemia].
abstract: The samples from blood and/or bone marrow were analysed in 7 children at the time of initial diagnosis or relapse and in 9 children with clinical and hematologic remission of ALL. Molecular genetic methods were more sensitive than morphologic ones in leukemic cells detection: 5 children in remission of ALL demonstrated gene rearrangements. Clinical significance of the presence of low numbers of leukemic cells in remissions is still unknown.
authors.affiliation: Kliniki Pediatrycznej PAM w Szczecinie.
authors.forename: W
authors.initials: W
authors.lastname: Podraza
authors.forename: E
authors.initials: E
authors.lastname: Osipowicz
authors.forename: K
authors.initials: K
authors.lastname: Ptaszyński
authors.forename: J
authors.initials: J
authors.lastname: Lubiński
authors.forename: J
authors.initials: J
authors.lastname: Fydryk
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics*; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*
chemical_list: D011948:Receptors, Antigen, T-Cell
vernacular_title: Ocena przemieszczeń genów immunoglobulinowych i receptorów limfocytów T w wykrywaniu śladowej liczby komórek nowotworowych u dzieci z ostra białaczka limfoblastyczna.