title: Substance P-like immunoreactivity and somatostatin-like immunoreactivity in the ventricular fluid of patients with chronic pain syndromes.
abstract: Substance P-like and somatostatin-like immunoreactivities (SPLI and SLI) were determined in ventricular fluid of patients with chronic pain syndromes and in a comparison group with multiple sclerosis, essential tremor, epilepsy and postanoxic myoclonus. Concentrations of SPLI and SLI were non-significantly decreased by 40% and 33% in chronic pain patients as compared with control patients without pain. There were no differences apparent between subgroups of pain patients (deafferentation pain, neoplasia-induced pain, thalamic pain). High pressure liquid chromatography combined with radioimmunoassay showed marked heterogeneity of SPLI and SLI.
authors.affiliation: Department of Neurology, University of Freiburg, Federal Republic of Germany.
authors.forename: S
authors.initials: S
authors.lastname: Jost
authors.forename: C
authors.initials: C
authors.lastname: Reuner
authors.forename: J
authors.initials: J
authors.lastname: Geiger
authors.forename: M
authors.initials: M
authors.lastname: Mohadjer
authors.forename: E
authors.initials: E
authors.lastname: Milios
authors.forename: H
authors.initials: H
authors.lastname: Cramer
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000134:cerebrospinal fluid*; D010455:Peptides / Q000134:cerebrospinal fluid*; D011863:Radioimmunoassay
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C029993:somatostatin-like peptides; C016116:substance P-like peptides