title: Effects of thymoxamine on corneal endothelium.
abstract: We have investigated the effects of 0.02 and 0.2% thymoxamine hydrochloride on the isolated rabbit corneal endothelium. The corneal swelling rate, measured by specular microscopy, indicated that 0.02% thymoxamine caused a swelling rate equal to controls while a 0.2% concentration caused a significantly increased swelling rate (34.1 vs 10.3 microns/h; P less than 0.05). The data suggests that the maximum recommended intracameral concentration of thymoxamine be 0.02% in order to allow a 10-fold safety factor for the corneal endothelium.
authors.affiliation: Department of Ophthalmology, Medical College of Georgia, Augusta 30912-3400.
authors.forename: K
authors.initials: K
authors.lastname: Green
authors.forename: J M
authors.initials: JM
authors.lastname: Chapman
authors.forename: L
authors.initials: L
authors.lastname: Cheeks
authors.forename: D S
authors.initials: DS
authors.lastname: Hull
mesh_terms: D000818:Animals; D015715:Corneal Edema / Q000473:pathology; D004728:Endothelium, Corneal / Q000187:drug effects* / Q000473:pathology; D005260:Female; D008297:Male; D013948:Moxisylyte / Q000633:toxicity*; D010477:Perfusion; D011817:Rabbits
chemical_list: D013948:Moxisylyte