Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection.
Seventy-two AIDS patients treated with ganciclovir for cytomegalovirus (CMV) disease were prospectively monitored for the development of drug-resistant virus. No resistant strains were found in 31 patients before therapy or among seven culture-positive patients treated for less than or equal to 3 months. Of 13 culture-positive patients treated for greater than or equal to 3 months, 5 excreted virus resistant (ED50, greater than 12 microM, or ED90, greater than 30 microM) to ganciclovir. Thus, 38% of patients and receiving ganciclovir for greater than 3 months and excreting virus or, overall, 7.6% of the patients were excreting CMV resistant to the drug.
Drew
W L
WL
Virology Research, Mount Zion Hospital and Medical Center, University of California, San Francisco 94115.
Miner
R C
RC
Busch
D F
DF
Follansbee
S E
SE
Gullett
J
J
Mehalko
S G
SG
Gordon
S M
SM
Owen
W F
WF
Matthews
T R
TR
Buhles
W C
WC
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D003587:Cytomegalovirus / Q000187:drug effects*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy*; D004352:Drug Resistance, Microbial; D015774:Ganciclovir / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D011446:Prospective Studies; D011897:Random Allocation; D014556:Urine / Q000382:microbiology
D015774:Ganciclovir