Evaluation of the purified fraction of Wilbrandia (c.f.) verticillata for antitumour activity.
Cucurbitacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wv1 and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and antitumour activities of these norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12 micrograms/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).
Rao
V S
VS
Departamento de Fisiologia e Farmacologia, UFC, Fortaleza, CE, Brasil.
Almeida
F R
FR
Moraes
A P
AP
Silva
J V
JV
Nascimento
S C
SC
Moraes
M O
MO
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000627:therapeutic use*; D001938:Brazil; D002279:Carcinoma 256, Walker / Q000188:drug therapy*; D054728:Cucurbitacins; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D014315:Triterpenes / Q000302:isolation & purification / Q000627:therapeutic use*
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; D054728:Cucurbitacins