In vitro photodynamic inactivation of herpes simplex virus with sapphyrins: 22 pi-electron porphyrin-like macrocycles.
The photodynamic inactivation of HSV-1, a virus having a membranous envelope, with both a decaalkyl sapphyrin and its dicarboxy-substituted analog was studied. The decaalkyl sapphyrin was as efficient in the inactivation of HSV-1 on a per macrocycle basis as DHE, whereas the efficiency of the dicarboxy-substituted sapphyrin was approximately two orders of magnitude less. Fluorescence studies of sapphyrin's binding to liposomes and VSV suggested that the decaalkylsapphyrin bound monomerically to cholesterol-rich regions of the viral envelope, whereas its charged analog localized in a more polar environment.
Judy
M M
MM
Baylor Research Foundation, Baylor University Medical Center, Dallas, TX 75226.
Matthews
J L
JL
Newman
J T
JT
Skiles
H L
HL
Boriack
R L
RL
Sessler
J L
JL
Cyr
M
M
Maiya
B G
BG
Nichol
S T
ST
D000818:Animals; D008027:Light; D008081:Liposomes; D011758:Pyrroles / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D014709:Vero Cells
D008081:Liposomes; D011758:Pyrroles; D011838:Radiation-Sensitizing Agents