An attempted reversal of cocaine-induced analgesia by dexamethasone.
Analgesia produced by systemic cocaine (20 mg/kg intraperitoneally) was not attenuated by dexamethasone (0.25-2.5 mg/kg) in the formalin or tail pinch test in rats. The result suggests that the activation of the corticotropin releasing factor-adrenocorticotropin/beta-endorphin axis does not explain cocaine-induced analgesia.
Pertovaara
A
A
Department of Physiology, University of Helsinki, Finland.
Kauppila
T
T
Mecke
E
E
D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003042:Cocaine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology*; D005557:Formaldehyde; D008297:Male; D010147:Pain Measurement; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects
D000700:Analgesics; D005557:Formaldehyde; D003907:Dexamethasone; D003042:Cocaine