title: Stimulatory effect of thyroid hormone on RA-induced granulocytic differentiation in leukemic cells.
abstract: Retinoic acid, vitamin D3, and dexamethasone are known inducers of myeloid leukemic cell differentiation. Recent evidence indicates that these drugs mediate their biological effects through binding to a nuclear receptor which belongs to the steroid/thyroid hormone receptor superfamily. This paper shows that the ligands of the other receptors of this family, estrogens, progesterone, androgens and thyroid hormone, do not induce leukemic cell differentiation. However, thyroid hormone potentiates, by one order of magnitude, the dose-response effect of retinoic acid in HL-60 cells.
authors.affiliation: Laboratoire de Biologie Cellulaire Hematopoïétique, Université Paris VII, France.
authors.forename: P
authors.initials: P
authors.lastname: Ballerini
authors.forename: M
authors.initials: M
authors.lastname: Lenoble
authors.forename: N
authors.initials: N
authors.lastname: Balitrand
authors.forename: G
authors.initials: G
authors.lastname: Schaison
authors.forename: Y
authors.initials: Y
authors.lastname: Najean
authors.forename: C
authors.initials: C
authors.lastname: Chomienne
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D002762:Cholecalciferol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D010100:Oxygen / Q000378:metabolism; D013268:Stimulation, Chemical; D013963:Thyroid Hormones / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D002762:Cholecalciferol; D014212:Tretinoin; D010100:Oxygen