title: Genetic variation in the Bribri and Cabecar Amerindians from Talamanca, Costa Rica.
abstract: A screening of more than 40 loci was performed in the Bribri and Cabecar Amerindian populations of Talamanca in Southeastern Costa Rica. Some differences were found in the distribution (presence or absence) of the variants (some of them private) of the GOT, PEPA, RH, TF and TPI loci when the results reported here were compared with those of the Bribris and Cabecars that inhabit in the Pacific side of the country. Admixture with non-Indians was detected at the ABO, ADA, and G6PD loci. The proportion of polymorphic loci (P) found were 17.1 in the Bribris and 19.4 in the Cabecars; their average heterozygosites (H) estimates were 0.039 and 0.049 respectively. Fst values (0.019 in the Bribris and 0.056 in the Cabecars) seem to indicate that random events have played important roles in the divergence of the Cabecars. Low effective population sizes of the emigrant groups to the Pacific side and probable gene flow in the case of the Bribris, could be the cause of these differences.
authors.affiliation: Instituto de Investigaciones en Salud (INISA), Universidad de Costa Rica.
authors.forename: J
authors.initials: J
authors.lastname: Azofeifa
authors.forename: R
authors.initials: R
authors.lastname: Barrantes
mesh_terms: D001788:Blood Grouping and Crossmatching; D003364:Costa Rica; D004586:Electrophoresis; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D007197:Indians, Central American / Q000235:genetics*; D011110:Polymorphism, Genetic