Oligodeoxynucleotide hybridization inhibition of HIV and influenza virus.
Synthetic oligodeoxyribonucleotides have been found to inhibit the replication and expression of HIV and of Influenza virus in growing tissue cultures. Nuclease resistant oligomers have been more effective than unmodified oligomers. In mouse and rat studies, labeled oligomers, on intravenous or intraperitoneal injection, leave the blood stream rapidly and enter numerous organs of the body. The half life in these organs is 24-48 hours in the case of the phosphorothioate oligomers.
Zamecnik
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Worcester Foundation for Experimental Biology, Shrewsbury, MA 01545.
Agrawal
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D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D002478:Cells, Cultured; D016679:Genome, Viral; D006678:HIV / Q000187:drug effects*; D006801:Humans; D051379:Mice; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D063086:Organothiophosphates / Q000494:pharmacology; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000235:genetics; D051381:Rats
D000998:Antiviral Agents; D009838:Oligodeoxyribonucleotides; D016376:Oligonucleotides, Antisense; D063086:Organothiophosphates