Repression by Jun of the Polyoma-virus enhancer overrides activation in a cell specific manner.
The activities of promoters and enhancers are generated by the combinatorial effects of the factors which interact with them. The Polyoma virus (Py) enhancer contains sequences that are positively regulated by the proto-oncogene Jun. Surprisingly, Jun has an additional and overriding repressing effect on enhancer activity, which is cell specific. Thus overall enhancer activity cannot be simply deduced from the properties of individual elements. We present evidence that repression is indirect.
Schneikert
J
J
CNRS-LGME/INSERM-U.184, Institut de Chimie Biologique, Faculté de Médecine, Strasboug, France.
Imler
J L
JL
Wasylyk
B
B
D015153:Blotting, Western; D004268:DNA-Binding Proteins / Q000235:genetics*; D004742:Enhancer Elements, Genetic; D005814:Genes, Viral; D016759:Oncogene Protein p65(gag-jun); D011120:Polyomavirus / Q000235:genetics*; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D011995:Recombination, Genetic; D012097:Repressor Proteins / Q000235:genetics*; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D014162:Transfection
D004268:DNA-Binding Proteins; D016759:Oncogene Protein p65(gag-jun); D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D012097:Repressor Proteins; D015682:Retroviridae Proteins, Oncogenic; D014157:Transcription Factors