Modulation of allogeneic cytotoxic activity by factor VIII or IX concentrates.
METHODS
The ability of peripheral blood mononuclear cells (PBMC) to generate cytotoxic T lymphocytes (CTL) that react against alloantigens was evaluated in hemophilic patients (He) with or without human immunodeficiency virus (HIV) infection.


CONCLUSIONS
We demonstrated that PBMC from HIV seronegative and seropositive He had a decreased response when compared to normal controls. The decreased CTL response to alloantigens may be due to the immunosuppressive effects of factor VIII or IX concentrates, as well as to the different pathway of HIV infection when compared to other acquired immunodeficiency syndrome risk groups.
Soria
A G
AG
Instituto de Investigaciones Hematologicas Mariano R. Castex, Academia Nacional de Medicina, Buenos Aires, Argentina.
Bouzas
M B
MB
Anselmo
A
A
Ruibal-Ares
B H
BH
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D003601:Cytotoxicity Tests, Immunologic; D005164:Factor IX / Q000276:immunology*; D005169:Factor VIII / Q000276:immunology*; D006679:HIV Seropositivity / Q000150:complications / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis; D006467:Hemophilia A / Q000150:complications / Q000276:immunology*; D002836:Hemophilia B / Q000276:immunology*; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer
D006680:HLA Antigens; D005169:Factor VIII; D005164:Factor IX