[The distribution of various type of oncogenes products in the tumor tissue of malignant mesothelioma].
The distribution of various oncogenes in the tumor tissues of 8 cases of malignant mesothelioma related to asbestos exposure was evaluated by monoclonal antibodies against oncogenes. There was no staining for K-ras, H-ras and erb-B in all cases and C-abl slightly stained in only one case of a biphasic type of tumor. On the other hand, C-myc positively stained in epithelioid type and the epitheloidal portion of the biphasic type of tumors. C-neu, C-fos and N-myc positively stained in almost all cases. Of these 9 oncogenes, C-neu was most frequently stained in all cases. These results suggest that C-myc, N-myc, C-neu and C-fos oncogenes may have some role in the appearance of malignant mesothelioma related to asbestos exposure.
Kishimoto
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Department of Clinical Investigation Kure Kyosai Hospital, Japan.
D000368:Aged; D001194:Asbestos / Q000009:adverse effects*; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008654:Mesothelioma / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D015513:Oncogene Proteins / Q000378:metabolism*; D011519:Proto-Oncogenes
D015513:Oncogene Proteins; D001194:Asbestos