Recovery of natural cytotoxicity after bone marrow transplantation.
Reconstitution of non-MHC restricted cytotoxicity was followed in 7 and in 4 cases after auto- and allotransplantation, respectively. In autografted cases a high level of natural cytotoxicity, which exceeded the pre-transplant values, was seen at the beginning of hematological reconstitution. At that time, the high percentage of DR+ peripheral blood mononuclear cells (PBMC) was found, while the percentage of CD16+ cells was in the range of the pre-transplant values. A high level of cytotoxicity was a transient phenomenon. In all cases, 40 days after grafting the natural cytotoxicity was again in the range of the pre-transplant values. In allotransplantation the peak of cytotoxicity was seen soon after the beginning of hematological recovery and the activity decreased after 24 to 48 days after grafting.
Lange
A
A
Bone Marrow Transplantation Unit, K. Dluski Hospital, Wroclaw, Poland.
Jazwiec
B
B
Tomaszewska-Toporska
B
B
Toporski
J
J
D000943:Antigens, Differentiation / Q000096:biosynthesis; D016026:Bone Marrow Transplantation / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D007167:Immunotherapy; D007694:Killer Cells, Natural / Q000276:immunology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000628:therapy; D008175:Lung Neoplasms / Q000276:immunology / Q000628:therapy; D008212:Lymphocyte Depletion; D011961:Receptors, Fc / Q000096:biosynthesis; D017452:Receptors, IgG; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D000943:Antigens, Differentiation; D006684:HLA-DR Antigens; D011961:Receptors, Fc; D017452:Receptors, IgG