title: Anticoccidial activity of 8-aminoquinolines, pamaquine, primaquine and several molecular complexes and salts of pamaquine, against Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti in battery experiments.
abstract: Pamaquine and primaquine, the well known antimalarial 8-aminoquinolines, have not been reported for their anticoccidial activity. A series of battery experiments was conducted to investigate their activity against a laboratory strain of Eimeria tenella, E. necatrix, E. acervulina, E. maxima, or E. brunetti and revealed that both drugs were effective against E. tenella and E. necatrix, but not against the other three species. Pamaquine suppressed the symptoms of E. tenella induced coccidiosis at concentrations above 125 ppm in feed and primaquine controlled the clinical signs as well at levels above 31.2 ppm. The activity against E. necatrix was observed with pamaquine at 250 ppm and with primaquine at levels above 125 ppm. Pamaquine showed a tendency apparently to reduce body weight gain at 125-500 ppm, whereas primaquine showed the same tendency at 500 ppm. In a concomitantly conducted experiment, this adverse effect of pamaquine was averted in its molecular complexes with benzophenone, nitropyrazole, dinitrobenzoic acids and quinoline, and in its salts of sulfate or zinc chloride, and yet these compounds retained the same anticoccidial activity as of pamaquine. This suggests that these compounds had the broadened safety margin. Judging from their susceptibility to these compounds. E. tenella and E. necatrix will have similar metabolic functions to those of blood cell parasitizing protozoa like plasmodia and prioplasma, which are easily suppressed by this class of compound.
authors.affiliation: Animal Health Research Laboratories, Agro Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsuno
authors.forename: F
authors.initials: F
authors.lastname: Hariguchi
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D002432:Cecum / Q000473:pathology; D002645:Chickens / Q000469:parasitology*; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000627:therapeutic use; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary; D007422:Intestines / Q000473:pathology; D008297:Male; D015394:Molecular Structure; D011201:Poultry Diseases / Q000188:drug therapy*; D011319:Primaquine / Q000737:chemistry / Q000627:therapeutic use*; D012492:Salts; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000634:Aminoquinolines; D000962:Antimalarials; D003049:Coccidiostats; D012492:Salts; C004331:pamaquine; D011319:Primaquine