[Effects of nicotinamide and oxythiamine on the lipogenic parameters of the adipose tissue of mice with non-insulin-dependent type of experimental diabetes mellitus and hyperinsulinemia].
The influence of nicotinamide and oxythiamine on the activity of NADPH-producing dehydrogenases of glucoso-6-phosphate, 6-phosphogluconate, malate, isocitrate, as well as concentration and synthesis rate of fatty acids in fatty tissue were studied in experiments on mice with genetically conditioned non-insulin-dependent diabetes and hyperinsulinemia. It has been established that in these diseases the synthesis of fatty acids and their inclusion into lipids are activated without increasing the above enzymes activity. It is shown that nicotinamide and oxythiamine inhibit inclusion of C from glucose into free fatty acids, antivitamin intensifies lipolysis in the fatty tissue of the diseased animals.
Pyzhik
T N
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Obrosova
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D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000096:biosynthesis*; D007328:Insulin / Q000097:blood*; D050356:Lipid Metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009536:Niacinamide / Q000494:pharmacology*; D010119:Oxythiamine / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D007328:Insulin; D010119:Oxythiamine; D009536:Niacinamide; D000429:Alcohol Oxidoreductases
Deĭstvie nikotinamida i oksitiamina na lipogennye parametry zhirovoĭ tkani mysheĭ s insulinnezavisimym tipom diabeta i giperinsulinemieĭ.