title: Lack of alloantigen-specific cytotoxic T cell activity in the TCR-gamma delta T cell subpopulation of alloantigen-immune chickens.
abstract: We examined the in vivo generation of alloantigen-specific cytotoxic T lymphocytes in chicken TCR-alpha beta and TCR-gamma delta T cells. The TCR-alpha beta and TCR-gamma delta subpopulations were separated from spleen of alloantigen-immune chickens using a negative selection method. The separated cells were examined for alloantigen-specific CTL activity in a 51Cr release assay. While negatively selected TCR-alpha beta cells exerted alloantigen-specific CTL activity, no cytotoxic activity could be detected with TCR-gamma delta cells.
authors.affiliation: Institute of Animal Physiology, University of Munich, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Cihak
authors.forename: H
authors.initials: H
authors.lastname: Merkle
authors.forename: U
authors.initials: U
authors.lastname: Lösch
mesh_terms: D000818:Animals; D015703:Antigens, CD; D002645:Chickens; D007114:Immunization; D007519:Isoantigens; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D007519:Isoantigens; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta