Physicochemical characterization of human herpesvirus 6 infectivity.
Infectivity of human herpesvirus 6 (HHV-6) was physicochemically characterized. Virus particles were excreted from infected cord blood mononuclear cells into the culture supernatant at a concentration of 10(8) to 10(9) virus particles/ml. The virus particle/infectivity ratio of HHV-6 in the culture supernatant was approximately 10(3):1 and that in the sonicated infected cells was 10(4):1. Infectivity was stable below 37 degrees C and at neutral pH (7.0 to 8.5). These fundamental data may be useful for serological and biological research on HHV-6.
Shiraki
K
K
Department of Virology, Osaka University, Japan.
Mukai
T
T
Okuno
T
T
Yamanishi
K
K
Takahashi
M
M
D002478:Cells, Cultured; D015654:Herpesvirus 6, Human / Q000254:growth & development* / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D007963:Leukocytes, Mononuclear; D008854:Microscopy, Electron; D013696:Temperature