Correlation between steroids and plasmin in rat ovaries during ovulatory process.
Progesterone (0.5 mg/rat) and estradiol-17 beta (10 micrograms/rat) injected(im) to adult female albino rats on the morning of proesterous significantly enhanced the ovarian plasmin activity as measured by the fibrin plate method at the time of ovulation which was confirmed to be at 2.30 a.m. by estimation of ovarian plasmin activity at definite intervals before and after ovulation. The ovarian plasmin activity showed a gradual increase towards ovulation and reached a maximum level at 2.30 a.m. and again decreased after ovulation. However, the nonsteroidal estrogen antagonist, tamoxifen induced inhibitory effects on the ovarian plasmin activity as compared to control and estradiol-17 beta treatment. Thus these studies reveal a positive relationship between steroids and the ovarian plasmin activity during ovulation.
Dhanju
C K
CK
Zoology Department, College of Basic Sciences & Humanities, Punjab Agricultural University, Ludhiana, India.
Dhanoa
S K
SK
Guraya
S S
SS
D000818:Animals; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D005341:Fibrinolysin / Q000378:metabolism*; D010053:Ovary / Q000378:metabolism*; D010060:Ovulation; D011374:Progesterone / Q000378:metabolism*; D051381:Rats
D011374:Progesterone; D004958:Estradiol; D005341:Fibrinolysin