title: Use of digital radiography to demonstrate the potential of naproxen as an adjunct in the treatment of rapidly progressive periodontitis.
abstract: The effect of the non-steroidal anti-inflammatory drug, naproxen, in reducing periodontal disease activity was assessed in 15 patients with rapidly progressive periodontitis. All patients in this double-blind study were treated with scaling and root planing. Thereafter, 7 patients receiving 500 mg naproxen b.i.d. for 3 months, and 8 patients received placebo. Disease activity was assessed in three ways. First, alveolar bone height was determined using standardized radiography. Second, alterations in alveolar bone metabolism were assessed using 99m-Tc-methylene diphosphonate uptake prior to dosing and 3 months later. Finally, bone loss or gain was detected using digital subtraction radiography. In this study, conventional subtraction images were processed to isolate the area of change and superimpose the change on the original radiograph. This allowed determination of both the direction and location of osseous changes. There was significantly less bone loss as determined by analysis of bone height during the 3-month study in the naproxen-treated patients when compared to the placebo-treated patients (p less than 0.001). Radiopharmaceutical uptake was significantly reduced in the alveolar bone in patients receiving naproxen (p less than 0.03), whereas no significant change was observed in the placebo-treated patients. Furthermore, the subtraction radiographs showed a significant increase in the proportion of teeth demonstrating bone gain in the naproxen-treated group. These findings indicate that naproxen may be a useful adjunct to scaling and root planing in patients with rapidly progressive periodontitis.
authors.affiliation: University of Alabama, School of Dentistry, Birmingham.
authors.forename: M K
authors.initials: MK
authors.lastname: Jeffcoat
authors.forename: R
authors.initials: R
authors.lastname: Page
authors.forename: M
authors.initials: M
authors.lastname: Reddy
authors.forename: A
authors.initials: A
authors.lastname: Wannawisute
authors.forename: P
authors.initials: P
authors.lastname: Waite
authors.forename: K
authors.initials: K
authors.lastname: Palcanis
authors.forename: R
authors.initials: R
authors.lastname: Cogen
authors.forename: R C
authors.initials: RC
authors.lastname: Williams
authors.forename: C
authors.initials: C
authors.lastname: Basch
mesh_terms: D000293:Adolescent; D000328:Adult; D016301:Alveolar Bone Loss / Q000188:drug therapy; D000539:Alveolar Process / Q000378:metabolism; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D006801:Humans; D009288:Naproxen / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010518:Periodontitis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D011856:Radiographic Image Enhancement; D011877:Radionuclide Imaging; D013382:Subtraction Technique; D013669:Technetium Tc 99m Medronate
chemical_list: D009288:Naproxen; D013669:Technetium Tc 99m Medronate