Effects of recombinant human alpha A interferon in gnotobiotic calves challenged with respiratory syncytial virus.
The effects of recombinant human alpha A interferon were studied in gnotobiotic calves challenged with respiratory syncytial virus (RSV). Gnotobiotic calves given doses of interferon by intramuscular injection over five days showed a marked, dose-related, rise in rectal temperature and depression of circulating leucocytes. Differential counts showed decreases in both lymphocytes and neutrophils. No significant pathological differences were found between treated and untreated calves, nor could any difference be demonstrated in the pattern of RSV infection.
Dennis
M J
MJ
AFRC Institute for Animal Health, Compton, Newbury, Berkshire.
Thomas
L H
LH
Stott
E J
EJ
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000382:microbiology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005856:Germ-Free Life; D006801:Humans; D007273:Injections, Intramuscular / Q000662:veterinary; D007370:Interferon Type I / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D007958:Leukocyte Count / Q000187:drug effects / Q000662:veterinary; D011994:Recombinant Proteins; D012192:Retroviridae Infections / Q000097:blood / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D016092:Spumavirus
D007370:Interferon Type I; D011994:Recombinant Proteins