[Autoimmune and immunocomplex pathology in patients with insulin-dependent diabetes mellitus].
The purpose of the study was to bring to light autoimmune reactions in patients with insulin-dependent diabetes mellitus (IDDM) with regard to different tissue autoantigens as well as to reveal association between changes in cellular reactions and molecular structure of circulating immune complexes. Altogether 71 IDDM patients were investigated using the leukocyte migration inhibition test (LMIT), in which sensitization to autoantigens was observed in thymic tissue (35.2%), skin (35.2%), venous walls (22.5%), lymph nodes (15.5%), human liver lipoprotein (25.4%). In the presence of diabetic angiopathies the frequency of lymphocyte sensitization to dermal antigen was increased 5.4-fold, to thymic antigen--6.6-fold, and to liver lipoprotein--10.4-fold. As the disease progressed, a considerable increase in the number of mean molecular (2.7-fold) and small molecular (1.6-fold) circulating immune complexes was observed. Direct correlation between their levels and severity of diabetic microangiopathies was established.
Frolov
V M
VM
Pinskiĭ
L L
LL
Peresadin
N A
NA
Veksler
Kh M
KhM
D000293:Adolescent; D000328:Adult; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology*; D002464:Cell Migration Inhibition; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000276:immunology*; D003925:Diabetic Angiopathies; D005260:Female; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology*; D008297:Male; D008970:Molecular Weight
D001324:Autoantigens
Autoimmunnaia i immunokompleksnaia patologiia u bol'nykh insulinzavisimym sakharnym diabetom.