Acute generalized exanthematic pustulosis. An atypical case due to nadoxolol?
A 74-year-old woman developed a generalized pustular dermatosis with erythema-multiforme-like and vesiculobullous lesions 10 days after beginning a treatment by nadoxolol. Despite the clinical polymorphism of the eruption, histology constantly revealed the presence of subcorneal pustules, even within the epidermis overlying subepidermal bullae. The eruption spontaneously healed after discontinuation of nadoxolol.
Bernard
P
P
Department of Dermatology, CHU Dupuytren, Limoges, France.
Bedane
C
C
Catanzano
G
G
Robbe
J
J
Bonnetblanc
J M
JM
D000208:Acute Disease; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004892:Erythema Multiforme / Q000139:chemically induced / Q000473:pathology; D005076:Exanthema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D010091:Oximes / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced / Q000473:pathology
D000889:Anti-Arrhythmia Agents; D010091:Oximes; C006154:nadoxolol