title: Anthelmintic efficacy of milbemycin D against Toxocara cati and Ancylostoma tubaeforme in domestic cats.
abstract: Anthelmintic efficacy of milbemycin D was evaluated against Toxocara cati and Ancylostoma tubaeforme in domestic cats. Twelve cats naturally infected with each nematode species were allocated among 2 groups of 6 animals each, and milbemycin D was orally administered to the 2 groups of cats in doses of 0.05 mg/kg and 0.1 mg/kg body weight, respectively. In all the cats infected with T. cati, fecal egg counts decreased followed by their disappearance from the feces and 2-35 worms were excreted into the feces after the medication in both doses of 0.05 mg/kg and 0.1 mg/kg. At postmortem of these medicated groups, no worms were detected from 4 cats of each group, but 1 and 2 immature worms were recovered from the other 2 cats respectively. In the cats infected with A. tubaeforme, fecal egg counts decreased followed by the disappearance from the feces and 2-62 worms were excreted into the feces in all the cats of the 2 groups, no nematodes remaining at postmortem. These results indicate that milbemycin D is fully effective against T. cati and A. tubaeforme in cats in a dose of 0.05-0.1 mg/kg.
authors.affiliation: First Department of Biochemistry, Faculty of Pharmacy, Meiji College of Pharmacy, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fukase
authors.forename: T
authors.initials: T
authors.lastname: In
authors.forename: S
authors.initials: S
authors.lastname: Chinone
authors.forename: S
authors.initials: S
authors.lastname: Akihama
authors.forename: H
authors.initials: H
authors.lastname: Itagaki
mesh_terms: D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D005243:Feces / Q000469:parasitology; D005260:Female; D018942:Macrolides; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D014120:Toxocariasis / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C027837:moxidectin