Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene.
The Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and bithorax (bx-C) complexes, and hence for the maintenance of segmental determination. We report the predicted protein sequence of the Pc-G gene Posterior Sex Combs (Psc), and of the neighbouring and related gene Suppressor two of zeste (Su(z)2). Both genes encode large proteins that contain a 200 amino-acid domain identical over 37.4% that is also conserved in the murine oncogene bmi-1. At the amino terminus of this domain is a cysteine-rich sequence that has been proposed as a novel type of zinc finger.
Brunk
B P
BP
Biology Department, University of Virginia, Charlottesville 22901.
Martin
E C
EC
Adler
P N
PN
D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000737:chemistry*; D015513:Oncogene Proteins / Q000737:chemistry*; D063150:Polycomb Repressive Complex 1; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D012689:Sequence Homology, Nucleic Acid; D016335:Zinc Fingers
C489421:Bmi1 protein, mouse; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; C071051:Su(z)2 protein, Drosophila; C071050:Psc protein, Drosophila; D063150:Polycomb Repressive Complex 1