Effect of MAP2, MAP2c, and tau on kinesin-dependent microtubule motility.
By making use of DIC video microscopy to monitor microtubule motility we have studied the effect of several MAPs (MAP2, MAP2c, tau) on microtubule-kinesin interactions and microtubule gliding. Of the three MAPs tested, MAP2 interferes most strongly with kinesin-dependent microtubule motility.
Heins
S
S
Max-Planck-Unit for Structural Molecular Biology, Hamburg, Germany.
Song
Y H
YH
Wille
H
H
Mandelkow
E
E
Mandelkow
E M
EM
D000251:Adenosine Triphosphatases / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D016547:Kinesins; D008869:Microtubule-Associated Proteins; D008870:Microtubules / Q000502:physiology*; D010784:Photomicrography; D013552:Swine; D014743:Videotape Recording; D016875:tau Proteins
D008869:Microtubule-Associated Proteins; D016875:tau Proteins; D000251:Adenosine Triphosphatases; D016547:Kinesins