title: Polymorphic oxidation of debrisoquine in lung cancer patients.
abstract: Oxidative polymorphism of debrisoquine (DBQ) was assessed in 84 patients (81 male) with histologically proven bronchogenic carcinoma and in 143 healthy male smokers. 80 (95%) patients and 133 (93%) controls, with a metabolic ratio (MR) below 12.6, were classified as extensive metabolisers of DBQ (no significant difference between patients and controls). Only 1 of the 73 patients with epidermoid or microcytic carcinomas was classified as a poor metaboliser (PM) (P = 0.031 compared with controls). 63 patients (75%) and 110 controls (77%) showed a very fast oxidative rate, with MR values under 1 (not significant). The EM phenotype of DBQ might be a secondary genetic risk factor for developing bronchogenic carcinoma in male smokers.
authors.affiliation: Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Benítez
authors.forename: J M
authors.initials: JM
authors.lastname: Ladero
authors.forename: C
authors.initials: C
authors.lastname: Jara
authors.forename: J A
authors.initials: JA
authors.lastname: Carrillo
authors.forename: J
authors.initials: J
authors.lastname: Cobaleda
authors.forename: A
authors.initials: A
authors.lastname: Llerena
authors.forename: E
authors.initials: E
authors.lastname: Vargas
authors.forename: J J
authors.initials: JJ
authors.lastname: Muñoz
mesh_terms: D000368:Aged; D002283:Carcinoma, Bronchogenic / Q000235:genetics / Q000378:metabolism*; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011110:Polymorphism, Genetic / Q000502:physiology*; D012307:Risk Factors; D012907:Smoking / Q000235:genetics / Q000378:metabolism
chemical_list: D003647:Debrisoquin