title: Myoclonic epileptic seizures during clozapine treatment: a report of three cases.
abstract: Three adult schizophrenic patients without a previous history of epilepsy are reported who, during clozapine treatment, developed paroxysmal EEG patterns and generalized myoclonic jerks without alteration of consciousness. These seizures were phenomenologically identical to those occurring in juvenile myoclonic epilepsy and were classified as generalized epileptic seizures. We tentatively conclude that generalized myoclonic epileptic seizures may be induced by clozapine.
authors.affiliation: Department of Psychiatry, University of Freiburg, Federal Republic of Germany.
authors.forename: E
authors.initials: E
authors.lastname: Gouzoulis
authors.forename: H
authors.initials: H
authors.lastname: Grunze
authors.forename: U
authors.initials: U
authors.lastname: von Bardeleben
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D004831:Epilepsies, Myoclonic / Q000139:chemically induced* / Q000503:physiopathology; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology
chemical_list: D003024:Clozapine