Quinolinic acid lesion of nucleus accumbens reduces D1 but not D2 dopamine receptors: an autoradiographic study.
Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 receptors (as labeled by [3H]SCH 23390). Contrarily, no appreciable decrement in D2 receptors (labeled by [3H]raclopride) could be identified within the same region of the NAcc. The findings support the view that accumbens D1 receptors are located postsynaptically on neurons or their processes, while D2 receptors within this nucleus are primarily located on afferent terminals.
Filloux
F
F
Department of Neurology, University of Utah School of Medicine, Salt Lake City 84132.
Richards
T J
TJ
Huff
G F
GF
Wamsley
J K
JK
D000818:Animals; D001345:Autoradiography; D001552:Benzazepines / Q000737:chemistry; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000473:pathology; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism
D001552:Benzazepines; D011805:Quinolinic Acids; D011954:Receptors, Dopamine; D017378:Quinolinic Acid