Further experience with the effect of some sugars on the growth and glycosylation of tumor line MCF-7.
The paper continues in the previous experiment indicating a possible control of glycosylation and differentiation processes in the in vitro cultured tumor cells using suitable types of saccharides in the culture medium. In this experiment the effect of lactose, L-fucose, D-glucose, and D-galactose was studied. To determine glycosylative changes the panel of six lectins with various sugar specificity was used. The obtained results indicate that a specific sugar may significantly affect not only the growth of cells but also glycosylation processes, including cell differentiation.
Mikolásková
J
J
Institute of Pathology, Medical Faculty, Palacký University, Olomouc, Czechoslovakia.
Majerová
S
S
Kolár
Z
Z
Negrini
R
R
D001943:Breast Neoplasms; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D005260:Female; D006001:Glycoconjugates / Q000032:analysis / Q000378:metabolism*; D006031:Glycosylation; D006601:Hexoses / Q000494:pharmacology*; D006801:Humans; D037102:Lectins
D006001:Glycoconjugates; D006601:Hexoses; D037102:Lectins