title: Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice.
abstract: Physical restraint administered to C57BL/6 mice significantly altered the inflammatory response to influenza virus infection and depressed anti-viral cellular immunity. Restraint-stressed animals showed a pattern of reduced mononuclear cell infiltration and lung consolidation which coincided with elevated plasma corticosterone levels. Furthermore, cellular immunity to virus was significantly depressed; interleukin-2 secretion was reduced by 96% and 59% in the mediastinal lymph nodes and spleens, respectively, as compared to a non-restrained group. However, the magnitude of the humoral immune response to influenza virus was unaffected by restraint stress. Anti-viral IgG antibody levels in restrained/infected mice did not differ when compared to a non-restrained/infected control group 14 days post-infection.
authors.affiliation: Section of Oral Biology, Ohio State University College of Dentistry, Columbus 43210.
authors.forename: J F
authors.initials: JF
authors.lastname: Sheridan
authors.forename: N G
authors.initials: NG
authors.lastname: Feng
authors.forename: R H
authors.initials: RH
authors.lastname: Bonneau
authors.forename: C M
authors.initials: CM
authors.lastname: Allen
authors.forename: B S
authors.initials: BS
authors.lastname: Huneycutt
authors.forename: R
authors.initials: R
authors.lastname: Glaser
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D003345:Corticosterone / Q000097:blood; D007074:Immunoglobulin G / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000473:pathology; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007376:Interleukin-2; D003345:Corticosterone