[Synthesis of 1-substituted nitroimidazoles and its evaluation as radiosensitizing agents].
The synthesis of various substituted nitroimidazoles with lipophilic and hydrophilic side chains as potential radiosensitizing agents is described. The starting material employed was 4(5)-nitroimidazole, which was alkylated via the sodium salt with various chloro-methylated, substituted alcohols and esters, in order to obtain analogues of misonidazole, metronidazole and desmethylmisonidazole of known radiosensitizing and bactericidal activity. Some final products were assayed for their radiosensitizing properties giving negative results under the testing conditions used.
Adams
D R
DR
Facultad de Farmacia, Universidad Central de Venezuela, Caracas.
Martul
R
R
Alvarez
M V
MV
López Zumel
M C
MC
Espada
M
M
D066298:In Vitro Techniques; D015394:Molecular Structure; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011836:Radiation Tolerance / Q000187:drug effects; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents
Síntesis de nitroimidazoles 1-sustituidos y su evaluación como radiosensibilizantes.