Alternative splicing of the beta A4 amyloid gene of Alzheimer's disease in cortex of control and Alzheimer's disease patients.
An S1 nuclease protection assay was designed to study the splicing pattern of the alternatively spliced beta A4 amyloid gene (APP gene) of Alzheimer's disease (AD). We determined the splicing pattern of the APP gene in fetal, adult, aged adult and AD human cortex. The results suggest that alternative splicing of the APP gene in AD is not significantly different from age-matched controls, but distinct from the developing fetal brain.
König
G
G
Center for Molecular Biology (ZMBH), University of Heidelberg, F.R.G.
Salbaum
J M
JM
Wiestler
O
O
Lang
W
W
Schmitt
H P
HP
Masters
C L
CL
Beyreuther
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics; D000544:Alzheimer Disease / Q000235:genetics*; D016229:Amyloid beta-Peptides / Q000235:genetics*; D002540:Cerebral Cortex / Q000196:embryology / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D012326:RNA Splicing; D012016:Reference Values; D015719:Single-Strand Specific DNA and RNA Endonucleases
D016229:Amyloid beta-Peptides; D015719:Single-Strand Specific DNA and RNA Endonucleases