Monocyte phagocytic activity in sickle cell disease.
The phagocytic activity of peripheral blood monocytes from sickle cell disease patients and normal controls was studied using a monocyte monolayer assay. Phagocytosis of antibody-coated red cells by monocytes from patients in stable condition and in normal controls did not differ significantly (7.1 +/- 1.5 vs. 5.3 +/- 0.9%). However, monocytes from sickle cell disease patients during vasoocclusive crises demonstrated increased phagocytic activity compared to the normal controls (11.0 +/- 2.7 vs. 5.3 +/- 0.9%, p less than 0.025). Numerous defects in immune response have been described in association with sickle cell disease. However, monocyte phagocytic activity is not deficient and is not a factor in the predisposition to infections.
Mendoza
E
E
William J. Harrington Center for Blood Diseases, University of Miami School of Medicine, Fla.
Gutgsell
N
N
Temple
J D
JD
Issitt
P
P
D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications; D006801:Humans; D009000:Monocytes / Q000502:physiology*; D010587:Phagocytosis; D014652:Vascular Diseases / Q000097:blood / Q000209:etiology