[The effect of ambroxol on peroxidative processes in dog lung mitochondria].
The influence of Ambroxol on the Fe3+ (ADP) dihydroxyfumarate-induced peroxidation of mitochondrial lipids in dog lung was investigated. It was shown that changes in mitochondrial lipid composition include great decrease in phosphatidylcholine and phosphatidylethanolamine content, with concomitant increase in lysophosphoglyceride content. Addition of Ambroxol (5 mM and 10 mM) to the incubation medium decreases these changes in dose-dependent manner. The malondialdehyde production was greatly reduced in the presence of Ambroxol. The mode of Ambroxol action was comparable to that of other free radical scavengers.
Ledwozyw
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A
Zakład Patofizjologii Akademii Rolniczej, Lublinie.
Jabłonka
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S
Tusińska
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E
D000551:Ambroxol / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism
D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D000551:Ambroxol; D008315:Malondialdehyde
Wpływ ambroksolu na procesy peroksydacyjne w mitochondriach płuc psa.