Gammavinylgaba increases high voltage spindle activity in control and nucleus basalis-lesioned rats after sub-chronic treatment.
The present study investigates the effects of gammavinylgaba (GVG, 4 days treatment at 50 and 200 mg/kg), a gabatransaminase inhibitor, on the high-voltage spindle (HVS) activity in control and nucleus basalis-lesioned rats. GVG treatment at 200 mg/kg, but not at 50 mg/kg increased HVS activity in controls. GVG greatly aggravated nucleus basalis magnocellularis (NBM) lesion-induced increase in HVS activity at 200 mg/kg, but not at 50 mg/kg. The present results demonstrate that partial NBM lesions increase the HVS inducing potency of GVG.
Riekkinen
P
P
Department of Neurology, University of Kuopio, Finland.
Sirviö
J
J
Riekkinen
M
M
Valjakka
A
A
Koivisto
E
E
Riekkinen
P
P
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000614:Aminocaproates / Q000494:pharmacology*; D000818:Animals; D004569:Electroencephalography / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013377:Substantia Innominata / Q000502:physiology*; D013997:Time Factors; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000614:Aminocaproates; D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase; D020888:Vigabatrin