[Correlations among FPB beta 15-42, PAC and D-dimer].
We measured FPB beta 15-42, and alpha 2 plasmin inhibitor-plasmin-complex (PAC), which are direct indexes of plasmin activity, as well as D-dimer in 204 samples from patients with subarachnoid hemorrhage, trauma, and the patients during cardiopulmonary bypass. In all patients, these molecular markers increased due to secondary fibrinolysis; these increases were significantly higher in DIC patients. There were positive correlations among the molecular markers. The correlation coefficient for FPB beta 15-42 and D-dimer was significantly higher than that for PAC and D-dimer in the DIC patients. In conclusion, it might be better to measure both FPB beta 15-42 and PAC as indexes of plasmin activity in DIC patients, because of the significant difference between the correlation coefficient for PAC and D-dimer, and that for FPB beta 15-42 and D-dimer.
Gando
S
S
Department of Emergency and Critical Care Medicine, Sapporo City General Hospital.
Tedo
I
I
D000328:Adult; D000933:Antifibrinolytic Agents / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D004211:Disseminated Intravascular Coagulation / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism*; D005345:Fibrinopeptide B / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism*; D000979:alpha-2-Antiplasmin
D000933:Antifibrinolytic Agents; D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; D000979:alpha-2-Antiplasmin; C036309:fibrin fragment D; C033786:fibrinogen Bbeta (15-42); C037742:plasmin-plasmin inhibitor complex; D005345:Fibrinopeptide B; D005341:Fibrinolysin