Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.
18 cloned T cell lines reactive with Borrelia burgdorferi proteins, all CD3+4+8-TCR-alpha/beta+ and restricted by HLA class II proteins, were isolated from four patients with chronic Lyme arthritis. Analysis of these T cell clones indicated that the T cell response to the Lyme disease spirochete is not oligoclonally restricted; yet all produced the same pattern of lymphokines, resembling that of murine type 1 T helper cells, after antigen-specific or nonspecific stimulation. Therefore, a subset of human CD4+ T cells, with a distinct profile of lymphokine secretion, is selectively activated by the pathogen inciting this chronic inflammatory disease.
Yssel
H
H
Department of Inflammation Biology, Syntex Research, Palo Alto, California 94303.
Shanafelt
M C
MC
Soderberg
C
C
Schneider
P V
PV
Anzola
J
J
Peltz
G
G
D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology; D001483:Base Sequence; D001898:Borrelia / Q000276:immunology*; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D002999:Clone Cells; D003001:Cloning, Molecular; D003602:Cytotoxicity, Immunologic; D015870:Gene Expression; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D008193:Lyme Disease / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000737:chemistry; D016133:Polymerase Chain Reaction; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D006680:HLA Antigens; D008222:Lymphokines; D009841:Oligonucleotides; D011948:Receptors, Antigen, T-Cell