Comparative evaluation of blood schizontocidal activity of quinine and quinidine against drug resistant rodent malaria.
Blood schizontocidal activity of quinine and quinidine has been compared against sensitive as well as chloroquine/mefloquine/quinine resistant strains of Plasmodium berghei and a multiple resistant strain of P. yoelii nigeriensis in Swiss mice. Evaluation of results on ED50/ED90 basis has shown distinct superiority of quinidine over quinine against sensitive as well as drug resistant strain of rodent malaria.
Kazim
M
M
Central Drug Research Institute, Lucknow, India.
Puri
S K
SK
Dutta
G P
GP
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D008288:Malaria / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D051379:Mice; D010962:Plasmodium berghei; D010967:Plasmodium yoelii; D011802:Quinidine / Q000008:administration & dosage / Q000627:therapeutic use*; D011803:Quinine / Q000008:administration & dosage / Q000627:therapeutic use*
D011803:Quinine; D011802:Quinidine