Does propofol have an anti-emetic effect? A prospective study of the anti-emetic effect of propofol following laparoscopy.
In order to investigate the putative anti-emetic effect of propofol, 53 patients undergoing gynaecological laparoscopy were given a standard anaesthetic including induction with thiopentone. At the end of surgery, the patients received either a sub-anaesthetic does of propofol or an equivalent volume of normal saline. There was no difference in the incidence of nausea and vomiting between the propofol and control group. It is concluded that low-dose propofol does not have an anti-emetic effect.
Campbell
N N
NN
Department of Anaesthetics, Gloucestershire Royal Hospital, Gloucester, England.
Thomas
A D
AD
D000328:Adult; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D008787:Metoclopramide / Q000008:administration & dosage / Q000627:therapeutic use; D009325:Nausea / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control; D015742:Propofol / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D014839:Vomiting / Q000517:prevention & control
D000932:Antiemetics; D008787:Metoclopramide; D015742:Propofol