Polymorphic oxidation of debrisoquine in lung cancer patients.
Oxidative polymorphism of debrisoquine (DBQ) was assessed in 84 patients (81 male) with histologically proven bronchogenic carcinoma and in 143 healthy male smokers. 80 (95%) patients and 133 (93%) controls, with a metabolic ratio (MR) below 12.6, were classified as extensive metabolisers of DBQ (no significant difference between patients and controls). Only 1 of the 73 patients with epidermoid or microcytic carcinomas was classified as a poor metaboliser (PM) (P = 0.031 compared with controls). 63 patients (75%) and 110 controls (77%) showed a very fast oxidative rate, with MR values under 1 (not significant). The EM phenotype of DBQ might be a secondary genetic risk factor for developing bronchogenic carcinoma in male smokers.
Benítez
J
J
Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz, Spain.
Ladero
J M
JM
Jara
C
C
Carrillo
J A
JA
Cobaleda
J
J
Llerena
A
A
Vargas
E
E
Muñoz
J J
JJ
D000368:Aged; D002283:Carcinoma, Bronchogenic / Q000235:genetics / Q000378:metabolism*; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011110:Polymorphism, Genetic / Q000502:physiology*; D012307:Risk Factors; D012907:Smoking / Q000235:genetics / Q000378:metabolism
D003647:Debrisoquin