[Ceruloplasmin in patients with Duchenne muscular dystrophy].
Duchenne muscular dystrophy is a well defined form of sex linked inherited muscular disease. Approximately 1/3 of cases are the product of a new mutation. We studied 20 patients with this disease and 19 heterozygous females. Ceruloplasmin levels were significantly higher in patients compared to controls. A possible protective role of this enzyme against oxydating agents may help prevent peroxydation of lipids from the smooth muscle cell membrane.
Reyes
J
J
Universidad de Valparaíso, Instituto de Rehabilitación Infantil, Universidad de Chile, Santiago.
Holmgren
J
J
Colombo
M
M
D000328:Adult; D002353:Carrier State / Q000097:blood*; D002570:Ceruloplasmin / Q000032:analysis* / Q000235:genetics / Q000502:physiology; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006579:Heterozygote; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D009136:Muscular Dystrophies / Q000201:enzymology* / Q000235:genetics; D009154:Mutation
D002570:Ceruloplasmin; D003402:Creatine Kinase
Ceruloplasmina en pacientes y portadores de distrofia muscular de Duchenne.