Synthesis and characterization of flavin modified oligodeoxyribonucleotide.
Oligonucleotides covalently linked to isoalloxazines via polymethylene linker were synthesized and characterized. The thymidine decamer having a primary aminoalkyl group at the 5'-end of internucleotide linkage was coupled with the activated ester of isoalloxazine in liquid-phase. The interaction of the flavin modified thymidine decamers with polydA was investigated by using spectrophotometric method.
Akiyama
T
T
Faculty of Pharmaceutical Science, Kyoto University, Japan.
Yoneda
F
F
Tanaka
K
K
Kuwabara
J
J
Sugiura
Y
Y
D001483:Base Sequence; D005415:Flavins / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D005415:Flavins; D009838:Oligodeoxyribonucleotides