title: Splanchnic surface oximetry during experimental portal hypertension and surgical manipulation of portosystemic shunts in dogs.
abstract: Surface oxygen tension (PSO2) was measured in dogs during experimental manipulation of the portal vein and hepatic artery, and during surgery to correct portosystemic shunting. There was no alteration in PSO2 of liver, pancreas, duodenum, or jejunum during partial (50%) or complete reduction of hepatic artery flow. After 100% reduction in portal vein blood flow, PSO2 was lower in jejunum, duodenum, and liver. With 50% reduction in portal flow, PSO2 was significantly decreased only in jejunum. In six dogs with single extrahepatic shunts, there was a significant correlation between portal pressure and jejunal PSO2. It was concluded that measurement of visceral organ PSO2 represents an accurate noninvasive means of obtaining objective data on the effect of reduction in hepatic blood flow on perfusion of other select splanchnic organs.
authors.affiliation: School of Medicine, University of Colorado Health Sciences Center, Denver.
authors.forename: S L
authors.initials: SL
authors.lastname: Peterson
authors.forename: C R
authors.initials: CR
authors.lastname: Gregory
authors.forename: J R
authors.initials: JR
authors.lastname: Snyder
authors.forename: P G
authors.initials: PG
authors.lastname: Whiting
authors.forename: D
authors.initials: D
authors.lastname: Strack
authors.forename: E M
authors.initials: EM
authors.lastname: Breznock
mesh_terms: D000818:Animals; D001785:Blood Gas Monitoring, Transcutaneous / Q000662:veterinary; D001794:Blood Pressure; D004283:Dog Diseases / Q000097:blood / Q000601:surgery*; D004285:Dogs; D004386:Duodenum / Q000098:blood supply; D006499:Hepatic Artery / Q000502:physiology*; D006975:Hypertension, Portal / Q000097:blood / Q000601:surgery / Q000662:veterinary*; D007583:Jejunum / Q000098:blood supply; D008099:Liver / Q000098:blood supply; D010100:Oxygen / Q000097:blood; D010179:Pancreas / Q000098:blood supply; D011168:Portal System / Q000002:abnormalities*; D011169:Portal Vein / Q000002:abnormalities / Q000502:physiology*; D012039:Regional Blood Flow
chemical_list: D010100:Oxygen