Efficacy of 5-fluorouracil in combination with methoxyphenyl maleamic acid in murine tumors.
Combination chemotherapy studies were carried out in vivo against sarcoma 180 (ascites)(S180) and Ehrlich (ascites) carcinoma (EAC) tumours using cytotoxic drugs and methoxyphenyl maleamic acid (MPMA), an intermediate in the synthesis of pyrrolidine-nitrogen-mustards. Preliminary data have suggested that the combination of 5-fluorouracil (5-FU) and methoxyphenyl maleamic acid (MPMA) was more active than 5-FU used singly against EAC tumour. The possible therapeutic potential of this combination was further investigated in EAC tumour.
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Bio-organic Unit, Tata Memorial Centre, Parel, Bombay.
Ambaye
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D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D008297:Male; D008298:Maleates / Q000008:administration & dosage*; D051379:Mice; D011897:Random Allocation; D012510:Sarcoma 180 / Q000188:drug therapy*
D008298:Maleates; D005472:Fluorouracil