Pharmacological screening of plants recommended by folk medicine as anti-snake venom--I. Analgesic and anti-inflammatory activities.
We have observed that several plants used popularly as anti-snake venom show anti-inflammatory activity. From the list prepared by Rizzini, Mors and Pereira some species have been selected and tested for analgesic activity (number of contortions) and anti-inflammatory activity (Evans blue dye diffusion--1% solution) according to Whittle's technique (intraperitoneal administration of 0.1 N-acetic acid 0.1 ml/10 g) in mice. Previous oral administration of a 10% infusion (dry plant) or 20% (fresh plant) corresponding to 1 or 2 g/kg of Apuleia leiocarpa, Casearia sylvestris, Brunfelsia uniflora, Chiococca brachiata, Cynara scolymus, Dorstenia brasiliensis, Elephantopus scaber, Marsypianthes chamaedrys, Mikania glomerata and Trianosperma tayuya demonstrated analgesic and/or anti-inflammatory activities of varied intensity.
Ruppelt
B M
BM
Departamento de Farmacologia, CCS-ICB, UFRJ, Ilha do Fundão, Rio de Janeiro, Brasil.
Pereira
E F
EF
Gonçalves
L C
LC
Pereira
N A
NA
D000700:Analgesics / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D001938:Brazil; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D012909:Snake Bites / Q000188:drug therapy*
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts