title: Paraspinal tumors: techniques and results of brachytherapy.
abstract: Because of their proximity to nerve roots and the spinal cord, it is frequently difficult to achieve complete resection of paraspinal tumors. We have used brachytherapy in an attempt to prevent local recurrence and its associated neurological sequelae. This report analyzes our experience with 35 patients to determine the feasibility, optimal techniques, and efficacy of this approach. The tumor types were non small-cell lung cancer (18), sarcomas (9), and other tumor types (8). Temporary, single plane implants using Ir-192 (median minimum peripheral dose 3000 cGy) were used in 21 patients, and permanent I-125 implants were used in 14 cases (median matched peripheral dose 12,500 cGy). Local control was achieved in 51% (18/35). However, local control was poor when lung cancers were implanted and in cases where the dura was exposed. Radiation myelitis did not occur despite the combined effects of previous external beam radiotherapy (N = 21) and brachytherapy. Our experience demonstrates that combined surgery and paraspinal brachytherapy can be performed with acceptable toxicity and is reasonably effective in preventing local relapse and its neurologic sequelae, particularly for tumors other than lung cancers.
authors.affiliation: Department of Radiation Oncology, Brachytherapy Service. Memorial Sloan-Kettering Cancer Center, N.Y. N.Y. 10021.
authors.forename: J G
authors.initials: JG
authors.lastname: Armstrong
authors.forename: D E
authors.initials: DE
authors.lastname: Fass
authors.forename: M
authors.initials: M
authors.lastname: Bains
authors.forename: B
authors.initials: B
authors.lastname: Mychalczak
authors.forename: D
authors.initials: D
authors.lastname: Nori
authors.forename: E
authors.initials: E
authors.lastname: Arbit
authors.forename: N
authors.initials: N
authors.lastname: Martini
authors.forename: L B
authors.initials: LB
authors.lastname: Harrison
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012509:Sarcoma / Q000532:radiotherapy*; D013125:Spinal Neoplasms / Q000378:metabolism* / Q000532:radiotherapy
chemical_list: D007457:Iodine Radioisotopes