title: The effect of metoprolol on left ventricular systolic and diastolic function in essential hypertension.
abstract: Using ultrasound techniques, parameters of left ventricular systolic and diastolic function were assessed in 23 patients with degree I-II essential hypertension treated with metoprolol. Metoprolol administration was followed by increases in ejection fraction (p less than 0.01) and stroke volume (p less than 0.05), a decrease in heart rate (p less than 0.01) while cardiac output remained unchanged. Left ventricular filling was abnormal in 12 patients (52.2%). After metoprolol, the ratio of early diastolic to late diastolic transmitral velocity (E/A) rose; the increase indirectly correlated both with the baseline value of E/A (r = -0.59, p less than 0.01), and the change in heart rate (t = -0.65, p less than 0.01). Improved left ventricular diastolic filling was significant only in patients showing abnormal baseline diastolic function, and may be due to the decrease in heart rate rather than a direct effect exerted by metoprolol on the myocardium.
authors.affiliation: IIIrd Medical Department, 1st Faculty of Medicine, Charles University, Prague, Czechoslovakia.
authors.forename: J
authors.initials: J
authors.lastname: Hradec
authors.forename: J
authors.initials: J
authors.lastname: Král
authors.forename: J
authors.initials: J
authors.lastname: Petrásek
mesh_terms: D000328:Adult; D000368:Aged; D006332:Cardiomegaly / Q000000981:diagnostic imaging / Q000188:drug therapy; D003692:Delayed-Action Preparations; D003971:Diastole / Q000187:drug effects*; D004452:Echocardiography / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D013599:Systole / Q000187:drug effects*; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D003692:Delayed-Action Preparations; D008790:Metoprolol