Synthesis and biological evaluations of some 2-thioxo-1,2,3,4-tetrahydropyrimidine derivatives.
Several 1,2,3,4-tetrahydro-6-methyl-4-(substituted phenyl)-2-thioxo-5-pyrimidinecarboxylic acid methyl esters were synthesized by condensing thiourea with methyl acetoacetate and substituted benzaldehydes according to Biginelli reaction. The structures of the compounds were confirmed by spectral and elemental analysis and their calcium antagonistic activities were investigated. Furthermore, the compounds synthesized in previous and present studies were evaluated for their antiaggregating activities.
Ertan
M
M
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey.
Balkan
A
A
Saraç
S
S
Uma
S
S
Rübseman
K
K
Renaud
J F
JF
D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology; D004095:Dihydropyridines / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D017275:Isradipine; D009682:Magnetic Resonance Spectroscopy; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013871:Thiones / Q000138:chemical synthesis / Q000494:pharmacology
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D010975:Platelet Aggregation Inhibitors; D011743:Pyrimidines; D013871:Thiones; D017275:Isradipine