title: Efficacy of long-term antimicrobial prophylaxis after acute pyelonephritis in pregnancy.
abstract: The efficacy of antimicrobial prophylaxis for recurrent urinary infection after an episode of acute febrile pyelonephritis was assessed in 27 pregnant women. Immediately following a 2-week treatment course for acute pyelonephritis, low-dose prophylaxis with a proper antimicrobial agent taken at bedtime daily was continued until 1 month after delivery. 23 women received 50 mg of nitrofurantoin, and 2 each were given 250 mg of amoxycillin and 250 mg of cephalexin, respectively. The treatment regimens were well tolerated and there were no breakthrough infections during a total of 7.8 patient-years of treatment. These results show that long-term low-dose antimicrobial prophylaxis is highly effective in this population at high risk of recurrent acute pyelonephritis.
authors.affiliation: Department of Infectious Diseases, University of Göteborg, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Sandberg
authors.forename: J E
authors.initials: JE
authors.lastname: Brorson
mesh_terms: D000208:Acute Disease; D000658:Amoxicillin / Q000627:therapeutic use*; D002506:Cephalexin / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D009582:Nitrofurantoin / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000517:prevention & control; D011704:Pyelonephritis / Q000188:drug therapy* / Q000517:prevention & control; D012008:Recurrence
chemical_list: D000658:Amoxicillin; D009582:Nitrofurantoin; D002506:Cephalexin