The effects of the fluorinated pyrimidines FUR, FUdR, FUMP, and FdUMP on human Tenon's fibroblasts.
5-Fluorouracil (5-FU) has effectively inhibited fibroblast proliferation to prevent scar formation and bleb failure after glaucoma filtering surgery. To identify more potent but less toxic antiproliferative drugs, the authors studied cell attachment and proliferation of 5-FU metabolites: 5-fluorouridine (FUR), 5-fluorodeoxyuridine (FUdR), 5-fluorouridine-5'-monophosphate (FUMP), and 5-fluorodeoxyuridine-5'-monophosphate (FdUMP) on human Tenon's fibroblasts in vitro.
Lee
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DA
University of California, Jules Stein Eye Institute, Los Angeles 90024-7004.
Shapourifar-Tehrani
S
S
Stephenson
T R
TR
Kitada
S
S
D000241:Adenosine / Q000493:pharmacokinetics; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D005123:Eye / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D005467:Floxuridine / Q000494:pharmacology*; D006801:Humans; D014343:Trypan Blue / Q000493:pharmacokinetics; D014500:Uracil Nucleotides / Q000494:pharmacology*; D014529:Uridine / Q000031:analogs & derivatives* / Q000494:pharmacology
D014500:Uracil Nucleotides; D005467:Floxuridine; C001943:5-fluorouridine; C016462:5-fluorouridine 5'-phosphate; D014343:Trypan Blue; D000241:Adenosine; D014529:Uridine