title: Myeloma associated scleromyxedema with extensive involvement of small bowel.
abstract: The details of a patient with disseminated scleromyxedema related to multiple myeloma are presented. Investigation demonstrated extensive accumulation of mucopolysaccharides in the skin, bone marrow and the small bowel submucosa. The latter finding is a most unusual manifestation of scleromyxedema and appeared to correlate with the patient's symptoms on presentation.
authors.affiliation: Department of Tissue Pathology, Monash Medical Centre, Prince Henry's Hospital, Melbourne.
authors.forename: J P
authors.initials: JP
authors.lastname: Dowling
authors.forename: J D
authors.initials: JD
authors.lastname: Griffiths
authors.forename: J A
authors.initials: JA
authors.lastname: McLeish
mesh_terms: D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000737:chemistry; D003967:Diarrhea / Q000209:etiology; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications* / Q000473:pathology; D007421:Intestine, Small / Q000737:chemistry / Q000473:pathology*; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology; D009230:Myxedema / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000737:chemistry; D015431:Weight Loss
chemical_list: D006025:Glycosaminoglycans