Adenylate cyclase activity in the families of alcoholics is controlled by a single major gene.
The stimulated activity of platelet adenylate cyclase (AC) has been shown to be significantly lower among alcoholics compared with controls. In this report we demonstrate that stimulated platelet AC activity is under the control of a single major gene locus. Thus a sensitive biological indicator of alcoholism has been shown to be highly heritable.
Devor
E J
EJ
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Cloninger
C R
CR
Hoffman
P L
PL
Tabakoff
B
B
D000262:Adenylyl Cyclases / Q000097:blood* / Q000235:genetics*; D000437:Alcoholism / Q000097:blood / Q000201:enzymology* / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000201:enzymology*; D002586:Cesium / Q000494:pharmacology; D004789:Enzyme Activation; D005190:Family; D005459:Fluorides / Q000494:pharmacology; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D012984:Software
D015415:Biomarkers; D002586:Cesium; D000262:Adenylyl Cyclases; D005459:Fluorides; C027754:cesium fluoride