title: Intra-abdominal desmoid tumors in familial polyposis coli: a case report of tumor regression by prednisolone therapy.
abstract: A case of intra-abdominal desmoid tumors in familial polyposis coli (FPC), which regressed and disappeared by prednisolone treatment, is reported. A 37-year-old Japanese man with abdominal lumps was admitted to our hospital. He had had proctocolectomy two years before because of FPC with rectal cancer. At laparotomy, tumors were present in the abdominal wall, mesentery, and retroperitoneum. Only a small part of the tumors was resected and diagnosed microscopically to be desmoid tumors. With prednisolone administration (20 to 5 mg/day) subjective symptoms were ameliorated and desmoid tumors slowly regressed. Bilateral hydronephrosis continued and resulted in "retroperitoneal fibrosis." To our knowledge, this case is the first well-documented case of retroperitoneal fibrosis in a patient with FPC. The characteristics of the desmoid tumor in familial polyposis coli or in Gardner's syndrome and the methods for its management are discussed.
authors.affiliation: Department of Surgery, Otawara Red Cross Hospital, Tochigi, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Umemoto
authors.forename: H
authors.initials: H
authors.lastname: Makuuchi
authors.forename: T
authors.initials: T
authors.lastname: Amemiya
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Oka
authors.forename: T
authors.initials: T
authors.lastname: Owada
authors.forename: K
authors.initials: K
authors.lastname: Koizumi
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011125:Adenomatous Polyposis Coli / Q000601:surgery; D000328:Adult; D003131:Combined Modality Therapy; D005350:Fibroma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007813:Laparotomy; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use*; D012074:Remission Induction; D012186:Retroperitoneal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D011239:Prednisolone