title: Genotoxicity of plant extracts.
abstract: Aqueous extracts of seven species used in Brazilian popular medicine (Achyrocline satureoides, Iodina rhombifolia, Desmodium incanum, Baccharis anomala, Tibouchina asperior, Luehea divaricata, Maytenus ilicifolia) were screened to the presence of mutagenic activity in the Ames test (Salmonella/microsome). Positive results were obtained for A. satureoides, B. anomala and L. divaricata with microsomal activation. As shown elsewhere (Vargas et al., 1990) the metabolites of A. satureoides extract also show the capacity to induce prophage and/or SOS response in microscreen phage induction assay and SOS spot chromotest.
authors.affiliation: Departamento do Meio Ambiente, Secretaria da Saúde e Meio Ambiente, Porto Alegre, RS, Brasil.
authors.forename: V M
authors.initials: VM
authors.lastname: Vargas
authors.forename: R R
authors.initials: RR
authors.lastname: Guidobono
authors.forename: J A
authors.initials: JA
authors.lastname: Henriques
mesh_terms: D000818:Animals; D001938:Brazil; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013014:SOS Response, Genetics / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D014775:Virus Activation / Q000187:drug effects; D014867:Water
chemical_list: D009153:Mutagens; D010936:Plant Extracts; D014867:Water