title: [Prevention of perinatal hepatitis B virus transmission. Epidemiology and cost/efficacy ratio in the Paris region].
abstract: The HBs antigen (AgHBs) was detected in 152 out of 6605 (2.3 percent) pregnant women who attended four representative maternity clinics in the Paris region. In 98 percent of the cases this finding reflected chronic hepatitis B virus infection. Among women born outside France (47 percent of the women tested, 79 percent of the AgHBs positive women), the relative risk was 6 for Asiatics, 5.5 for Africans and 4 for French women born in overseas departments or territories. Whatever the women's geographical origin, studies of their medical history revealed no significant difference between AgHBs positivity and AgHBs negativity. Overcrowding and multiparity correlated globally with the presence of AgHBs, but this correlation was absent in French women born in France. In non-African and non-Asiatic women detection guided by medical and socio-familial criteria would not be efficacious. The authors recommend systematic detection of AgHBs in pregnant women and estimate at about 180,000 french francs the cost of prevention for each case evolving toward the vital complications of chronic hepatitis B virus infection, an outcome which in the long term may affect 600 individuals born each year and who had contracted the infection during the perinatal period.
authors.affiliation: Centre d'Hémobiologie périnatale, Hôpital Jean-Verdier, Bondy.
authors.forename: J C
authors.initials: JC
authors.lastname: Soulié
authors.forename: A
authors.initials: A
authors.lastname: Goudeau
authors.forename: M
authors.initials: M
authors.lastname: Larsen
authors.forename: F
authors.initials: F
authors.lastname: Parnet
authors.forename: F
authors.initials: F
authors.lastname: Dubois
authors.forename: F
authors.initials: F
authors.lastname: Pinon
authors.forename: J
authors.initials: J
authors.lastname: Huchet
authors.forename: Y
authors.initials: Y
authors.lastname: Brossard
mesh_terms: D000328:Adult; D005260:Female; D005602:France; D006509:Hepatitis B / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011296:Prenatal Diagnosis; D015995:Prevalence; D012307:Risk Factors
chemical_list: D006511:Hepatitis B Antigens
vernacular_title: Prévention de la transmission périnatale du virus de l'hépatite B. Epidémiologie et rapport coût/efficacité dans la région de Paris.