title: Identification of a previously unrecognized production site of human renin.
abstract: We found expression of the renin gene in the intestine of human, mouse and the transgenic mouse in which the 3' flanking sequences of the human renin gene function as a tissue-specific promoter. A cotransfection analysis showed that the promoter is activated by the product of adenovirus E1A 13S mRNA in cells originated from extrarenal tissues.
authors.affiliation: Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
authors.forename: M S
authors.initials: MS
authors.lastname: Seo
authors.forename: A
authors.initials: A
authors.lastname: Fukamizu
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Murakami
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D017456:Adenovirus Early Proteins; D000818:Animals; D015152:Blotting, Northern; D005786:Gene Expression Regulation / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D007082:Ileum / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012083:Renin / Q000235:genetics*; D012260:Ribonucleases / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics; D014162:Transfection / Q000235:genetics
chemical_list: D017456:Adenovirus Early Proteins; D009856:Oncogene Proteins, Viral; D014157:Transcription Factors; D012260:Ribonucleases; D012083:Renin