Passive immunization for the treatment and prevention of HIV infection.
Passive immunization using serum or immunoglobulin preparations has been used in the prophylaxis and treatment of many bacterial and viral diseases. Preliminary attempts to use these methods to prevent HIV infection in chimpanzees have been promising. With the identification of polyclonal and monoclonal antibodies with protective activity against HIV in in vitro systems, the possibility of using these reagents in vivo takes on new relevance. The potential and problems of using passively administered anti-HIV antibodies for HIV prophylaxis and treatment are discussed, as well as the relative merits of polyclonal versus monoclonal reagents.
Karwowska
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S
Department of Pathology, New York University Medical Center, New York.
Zolla-Pazner
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S
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D005260:Female; D015483:HIV Antibodies; D015658:HIV Infections / Q000517:prevention & control / Q000628:therapy* / Q000635:transmission; D006801:Humans; D007116:Immunization, Passive; D016219:Immunotherapy, Adoptive; D008431:Maternal-Fetal Exchange; D009500:Neutralization Tests; D002679:Pan troglodytes; D011247:Pregnancy
D000911:Antibodies, Monoclonal; D015483:HIV Antibodies