Effect of monoclonal antibodies on in vitro function of T-cell subsets.
We have examined the functional heterogeneity of 43 monoclonal antibodies which recognised CD1, CD2, CD4, CD5, CD6 or CD8. Blocking of the proliferative response to alloantigen, virus, and phytoheamagglutinin (PHA) was studied. The majority of anti-CD2 and CD4 antibodies could inhibit an alloantigen response. Some of the anti-CD5 and CD8 antibodies could also block this response. Only a few antibodies to CD2 and CD4 could prevent proliferation of lymphocytes to PHA or virus.
Eskra
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Department of Veterinary Science, University of Wisconsin, Madison 53706.
O'Reilly
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Splitter
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GA
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D000943:Antigens, Differentiation / Q000276:immunology; D002417:Cattle; D016130:Immunophenotyping; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D008934:Mitogens / Q000494:pharmacology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D008934:Mitogens