title: A clinical and histopathologic study of granulomatous rosacea.
abstract: A retrospective clinical and histopathologic study of 53 patients with granulomatous rosacea was undertaken. The patients had a broad clinical spectrum of lesions that ranged from primarily erythema to papulonodular lesions. Extrafacial lesions occurred in 15% of patients. Histologic examination showed mixed lymphohistiocytic inflammation (primarily lymphocytic inflammation in 40% of patients and primarily histiocytic with a few giant cells in 34%), epithelioid granulomas in 11% of patients, and epithelioid granulomas with caseation necrosis in 11%. Most patients had a good response to oral antibiotic therapy. Granulomatous rosacea is not a distinct disease but can be regarded and treated as a subtype of rosacea.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
authors.forename: K F
authors.initials: KF
authors.lastname: Helm
authors.forename: J
authors.initials: J
authors.lastname: Menz
authors.forename: L E
authors.initials: LE
authors.lastname: Gibson
authors.forename: C H
authors.initials: CH
authors.lastname: Dicken
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001768:Blister / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology; D004890:Erythema / Q000473:pathology; D005260:Female; D005499:Folliculitis / Q000473:pathology; D006099:Granuloma / Q000188:drug therapy / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012393:Rosacea / Q000188:drug therapy / Q000473:pathology*; D016037:Single-Blind Method; D012867:Skin / Q000098:blood supply / Q000473:pathology; D015595:Skin Aging / Q000473:pathology; D013684:Telangiectasis / Q000473:pathology