Comparative therapeutic efficacy of teicoplanin and vancomycin in normal and in neutropenic mice infected with Staphylococcus haemolyticus.
This study describes the evaluation of a murine bacteraemia model for assessing antibiotic efficacy in normal and neutropenic mice infected with coagulase-negative staphylococci. In one such evaluation, it was found that there was no significant (P greater than 0.05) difference in the ability of teicoplanin or vancomycin to protect normal or neutropenic CD-1 mice, lethally-infected with Staphylococcus haemolyticus. However, about a four-fold increase of either antibiotic was needed to protect the immunocompromised animals.
Torney
H L
HL
Department of Pharmacology, Marion Merrell Dow Research Institute, Indianapolis.
Balistreri
F J
FJ
Kenny
M T
MT
Cheng
W D
WD
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy*; D005260:Female; D006020:Glycopeptides / Q000008:administration & dosage / Q000627:therapeutic use; D051379:Mice; D009503:Neutropenia / Q000150:complications*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D017334:Teicoplanin; D014640:Vancomycin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D017334:Teicoplanin; D014640:Vancomycin