B-N-acetyl hexosaminidase (B-NAH) serum levels after endotoxin administration into the portal vein in the rat.
Endotoxin was injected directly into the portal vein in rats with and without common bile duct (CBD) ligation. B-N-acetyl hexosaminidase (B-NAH) activity levels in the serum were found to be significantly elevated 24 h later in both groups. Serum bile acid levels were found to be significantly higher in the endotoxin-injected groups of rats compared to controls. Thus, endotoxin, as well as bile acids, may cause damage to Kupffer cell membranes, resulting in accumulation of B-NAH in rat serum.
Scapa
E
E
Department of Gastroenterology, Assaf Harofeh Medical Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Israel.
Orda
R
R
Neuman
M
M
Sayfan
J
J
Abramovici
J
J
Eshchar
J
J
D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood; D002462:Cell Membrane / Q000187:drug effects; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D054819:Hexosaminidase B; D007728:Kupffer Cells / Q000187:drug effects / Q000502:physiology*; D011169:Portal Vein; D051381:Rats; D013997:Time Factors; D001619:beta-N-Acetylhexosaminidases / Q000097:blood*
D001647:Bile Acids and Salts; D004731:Endotoxins; D054819:Hexosaminidase B; D001619:beta-N-Acetylhexosaminidases