title: Enantio- and meso-oligodeoxyribonucleotides.
abstract: As sugar-modified oligodeoxyribonucleotides, L-homooligomers (L-dA12 and L-dT12) and a L/D-alternative oligomer ((L-dA-D-dA)6) were synthesized. These oligomers were quite resistant towards phosphodiesterase degradations. L-dA12 formed complexes with poly(dT) and poly(U) at 0 degree C with different stabilities, on the other hand L-dT12 did not show obvious hypochromicities after mixing with complementary natural homopolymers. An alternative sequence, (L-dA-D-dA)6, interacted with both type homopolymers and stabilities of the complexes increased compared to that of L-dA12.
authors.affiliation: Faculty of Pharmaceutical Science, University of Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Fujimori
authors.forename: N
authors.initials: N
authors.lastname: Iwanami
authors.forename: K
authors.initials: K
authors.lastname: Shudo
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D011071:Poly T / Q000737:chemistry; D011072:Poly U / Q000737:chemistry; D013696:Temperature
chemical_list: D009838:Oligodeoxyribonucleotides; D011071:Poly T; D011072:Poly U