Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity.
The suppressive activity of normal human chromosome 5 was detected by means of the chromosomal transfer technique using DT cells as recipients. A hybrid clone, which exhibited reduced tumorigenicity, contained chromosomal regions such as 5pter-p15, q21 and q33-qter. Since a familial adenomatous polyposis gene has been reported to be located at 5q21-q22, the suppressive activity of chromosome 5 might be due to this gene.
Hoshino
Y
Y
Department of Hygiene and Oncology, Tokyo Medical and Dental University School of Medicine, Japan.
Horikawa
I
I
Oshimura
M
M
Yuasa
Y
Y
D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000818:Animals; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure*; D016153:Genes, Suppressor; D006801:Humans; D006822:Hybrid Cells / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D014407:Tumor Cells, Cultured