title: Teicoplanin does not modify the hypoglycemic effects of phenformin or glibenclamide, nor the anticoagulant action of warfarin. Experimental study.
abstract: Eventual pharmacological interactions induced by teicoplanin administration associated with oral hypoglycemic (phenformin and glibenclamide) and oral anticoagulant (warfarin) drugs have been experimentally evaluated. The administration of teicoplanin (3-15 mg/kg/die by endoperitoneal route) to the rat for 4 days did not significantly (P greater than 0.05) modify glycemia, prothrombin and partial thromboplastin times, the hypoglycemic effect of phenformin (2.5 mg/kg/die/4 days) or glibenclamide (0.5 mg/kg/die/4 days) nor the anticoagulant effect of warfarin (0.5 mg/kg/die/4 days). In conclusion, our results document that teicoplanin does not interfere with the activity of phenformin, glibenclamide or sodium warfarin.
authors.affiliation: Institute of Pharmacology and Toxicology, 1st Faculty of Medicine and Surgery, University of Naples Federico II, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.forename: R
authors.initials: R
authors.lastname: Marrazzo
authors.forename: C
authors.initials: C
authors.lastname: Lucarelli
authors.forename: I
authors.initials: I
authors.lastname: Marabese
authors.forename: D
authors.initials: D
authors.lastname: De Santis
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004347:Drug Interactions; D005260:Female; D005905:Glyburide / Q000008:administration & dosage / Q000494:pharmacology*; D006020:Glycopeptides / Q000008:administration & dosage / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007441:Intubation, Gastrointestinal; D008297:Male; D010314:Partial Thromboplastin Time; D010629:Phenformin / Q000008:administration & dosage / Q000494:pharmacology*; D011517:Prothrombin Time; D051381:Rats; D011919:Rats, Inbred Strains; D017334:Teicoplanin; D014859:Warfarin / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D006020:Glycopeptides; D014859:Warfarin; D017334:Teicoplanin; D010629:Phenformin; D005905:Glyburide