title: [Multicentric clinical trial of a combination of 35 micrograms of ethinylestradiol and 2 mg of cyproterone acetate].
abstract: The authors report the results of an open multicentric study of 136 women treated by a combination of 35 micrograms ethinylestradiol and 2 mg cyproterone acetate for cutaneous manifestation of hyperandrogenism. No pregnancy occurred during the treatment of 12 months. Comparison between the last treated and non treated cycle showed a significant difference (p less than 0.001) in the severity of acne lesions regardless of their sites. General and gynaecological tolerance were excellent.
authors.forename: A
authors.initials: A
authors.lastname: Audebert
authors.forename: J C
authors.initials: JC
authors.lastname: Emperaire
authors.forename: A
authors.initials: A
authors.lastname: Gauthier
authors.forename: P
authors.initials: P
authors.lastname: Hallonet
authors.forename: B
authors.initials: B
authors.lastname: Hedon
authors.forename: P
authors.initials: P
authors.lastname: Lopes
authors.forename: C
authors.initials: C
authors.lastname: Quereux
authors.forename: R
authors.initials: R
authors.lastname: Roulier
mesh_terms: D000152:Acne Vulgaris / Q000453:epidemiology / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000726:Androgen Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D001941:Breast Diseases / Q000453:epidemiology / Q000209:etiology; D003534:Cyproterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017373:Cyproterone Acetate; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010146:Pain / Q000453:epidemiology / Q000209:etiology; D014592:Uterine Hemorrhage / Q000453:epidemiology / Q000209:etiology; D014770:Virilism / Q000150:complications / Q000188:drug therapy*
chemical_list: D000726:Androgen Antagonists; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; D003534:Cyproterone
vernacular_title: Etude clinique multicentrique d'une association de 35 micrograms d'éthinylestradiol et de 2 mg d'acétate de cyprotérone.