title: Normal serum immunoglobulins influence the numbers of bone marrow pre-B and B cells.
abstract: The homeostatic mechanisms controlling B lymphocyte output from bone marrow are not well understood. The present experiments evaluated putative influences of circulating immunoglobulins (Ig) on bone marrow (BM) pre-B and B cell populations. Injections into normal mice of Ig isolated from normal mouse serum, resulted in a dose-dependent and reversible reduction in numbers of BM B lineage cells, in particular of small B220+ surface IgM- cells. Maximal effects were observed upon injection of isologous polyclonal Ig and were independent of mature T cells. These results suggest a feedback modulation of peripheral Ig on cellular activities in BM B lineage compartments, mediated by mechanisms that seem to involve the variable regions of the Ig molecule.
authors.affiliation: Unité d'Immunobiologie, CNRS URA 359, Institut Pasteur, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Sundblad
authors.forename: M
authors.initials: M
authors.lastname: Marcos
authors.forename: F
authors.initials: F
authors.lastname: Huetz
authors.forename: A
authors.initials: A
authors.lastname: Freitas
authors.forename: C
authors.initials: C
authors.lastname: Heusser
authors.forename: D
authors.initials: D
authors.lastname: Portnoï
authors.forename: A
authors.initials: A
authors.lastname: Coutinho
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D001854:Bone Marrow Cells; D005856:Germ-Free Life; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D007135:Immunoglobulin Variable Region / Q000502:physiology; D007136:Immunoglobulins / Q000502:physiology*; D007958:Leukocyte Count; D008264:Macrophages / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013047:Specific Pathogen-Free Organisms; D013601:T-Lymphocytes / Q000502:physiology
chemical_list: D007135:Immunoglobulin Variable Region; D007136:Immunoglobulins