title: Experimental transplantation models of mouse sarcoma 180 in ICR mice for evaluation of anti-tumor drugs.
abstract: Two new experimental models of transplantable mouse sarcoma 180 were developed in ICR mice in order to examine the optimum transplantation sites and methods. The cervicodorsal hypoderm was evaluated as the best transplantation site for mouse sarcoma 180 among seemingly usable transplantation sites such as groin, armpit, cervicodorsal, abdominal and lumbodorsal hypoderms by hypodermic transplantation. In addition, the lung transplantation model was established by monitoring the survival period as a reliable parameter for evaluation of anti-tumor effects.
authors.affiliation: Central Research Laboratories, Mercian Corporation, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shirai
authors.forename: H
authors.initials: H
authors.lastname: Izumi
authors.forename: T
authors.initials: T
authors.lastname: Yamagami
mesh_terms: D015250:Aclarubicin / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003630:Daunorubicin / Q000627:therapeutic use; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation; D012510:Sarcoma 180 / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy; D013047:Specific Pathogen-Free Organisms
chemical_list: D000970:Antineoplastic Agents; C011157:aclacinomycins; D015250:Aclarubicin; D004317:Doxorubicin; C027260:pirarubicin; D003630:Daunorubicin