Anti-ischaemic properties of amlodipine, a new calcium antagonist, in patients with severe coronary artery disease: a prospective trial.
Amlodipine significantly reduced both weekly anginal attack rate and consumption of glyceryl trinitrate tablets in patients with severe coronary artery disease. Exercise tolerance also significantly improved, with a 79% increase in the exercise time to onset of angina and a 59% decrease in ST-segment depression. Blood pressure was decreased, with no significant change in heart rate. No serious adverse events occurred in any patient during amlodipine treatment.
Navarro Estrada
J
J
Division of Cardiology, Hospital Italiano, Buenos Aires, Argentina.
Saglietti
H
H
Dimarco
M
M
Casabé
H
H
Oliveri
R
R
D017311:Amlodipine; D000787:Angina Pectoris / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy*; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005996:Nitroglycerin / Q000627:therapeutic use; D011446:Prospective Studies
D002121:Calcium Channel Blockers; D017311:Amlodipine; D005996:Nitroglycerin; D009543:Nifedipine