Nephrotoxicity from chemotherapy: prevention and management.
Among the most devastating effects of antineoplastic chemotherapy is nephrotoxicity. This article discusses the effects of plicamycin, methotrexate, mitomycin C, nitrosoureas, 5-azacytidine, cisplatin, ifosfamide, carboplatin, and gallium nitrate on kidney function when these drugs are used either alone or in combination with each other and/or other agents. The importance of adequate hydration during chemotherapy in preventing and reversing drug-induced nephrotoxicity is also discussed.
Vogelzang
N J
NJ
Section of Hematology/Oncology, University of Chicago.
D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016190:Carboplatin / Q000009:adverse effects / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use; D005708:Gallium / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects / Q000627:therapeutic use; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D016685:Mitomycin / Q000009:adverse effects / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*; D009607:Nitrosourea Compounds / Q000009:adverse effects / Q000627:therapeutic use; D008926:Plicamycin / Q000009:adverse effects / Q000627:therapeutic use
D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; D016685:Mitomycin; D016190:Carboplatin; D005708:Gallium; D008926:Plicamycin; D002945:Cisplatin; D007069:Ifosfamide; C027235:gallium nitrate; D008727:Methotrexate