title: Role of dopamine1-receptors in mediating renal responses to furosemide in the rat.
abstract: 1. Dopamine (DA) infusion enhanced the diuresis, natriuresis and kaliuresis evoked by furosemide, but this increase was significantly lower in the presence of SCH 23390, a selective DA1-dopaminergic antagonist. 2. Water, Na+ and K+ excretion induced by furosemide were reduced by haloperidol, and SCH 23390, whereas they were not affected by +/- sulpiride, a preferentially DA2-dopaminergic antagonist. 3. The treatments used did not modify the mean blood pressure during the experiments. 4. Our data show that renal responses to furosemide are attenuated by the DA1-dopaminergic antagonist. It is possible that endogenous DA, stimulating DA1 receptors in the rat kidney may be an important factor involved in the Na+, K+ and water excretion evoked by furosemide.
authors.affiliation: Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, UBA, Buenos Aires, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Nowicki
authors.forename: M A
authors.initials: MA
authors.lastname: Enero
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*; D017447:Receptors, Dopamine D1; D012964:Sodium / Q000652:urine; D013469:Sulpiride / Q000494:pharmacology
chemical_list: D001552:Benzazepines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D005665:Furosemide; D013469:Sulpiride; D012964:Sodium; D006220:Haloperidol; D011188:Potassium; D004298:Dopamine