[Effects of gabexate mesilate (FOY) on the gallbladder, sphincter of Oddi and duodenum of the normal and gastrectomized dogs].
FOY induced a dose-dependent inhibitory response on the gallbladder, sphincter of Oddi and duodenum of normal and gastrectomized dogs, although it induced an excitatory response in some dogs. The inhibitory response was not reduced or terminated by pretreatment with atropine, guanethidine, hexamethonium or/and proglumide. The FOY-induced inhibitory response reversed to the excitatory response in the sphincter of Oddi and duodenum by pretreatment with tetrodotoxin, but not in the gallbladder. These results suggested that the FOY-induced inhibitory response of the sphincter of Oddi and duodenum was caused by stimulation of nonadrenergic noncholinergic inhibitory neurons, not by FOY-induced cholecystokinin secretion. The excitatory response was induced by direct stimulation of their smooth muscles. The inhibitory response of the gallbladder to FOY was induced by direct stimulation of the smooth muscles.
Yamasato
T
T
Second Department of Physiology, Okayama University Medical School, Japan.
Mori
M
M
Mimura
H
H
Hamazaki
K
K
Kashino
H
H
Gouchi
A
A
Okabayashi
T
T
Tsuge
H
H
Miyake
J
J
Suga
H
H
D000818:Animals; D003864:Depression, Chemical; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000187:drug effects*; D005260:Female; D016670:Gabexate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005704:Gallbladder / Q000187:drug effects*; D005743:Gastrectomy; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D009803:Sphincter of Oddi / Q000187:drug effects*; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin; D016670:Gabexate