Is dehydroepiandrosterone-sulphate a possible pathogenetic factor in osteopenia of patients with iron overload?
Bone metabolism studies were performed on 5 patients with transfusional haemosiderosis (2 male, 3 female; mean age: 30.8 years) and 5 patients with idiopathic haemochromatosis (2 male, 3 female; mean age: 48.8 years). In the majority of the patients, the modern osteodensitometric method showed a significant decrease of the mineral content of the trabecular and cortical bones. Low calcitonin and dehydroepiandrosterone-sulphate concentrations were measured in the majority of the patients with calcipenic osteopathy. Besides marked bone loss, hypogonadotropic hypogonadism was found in 3 male patients, while normal LH, FSH concentration values were measured in 3 female patients. The prolactin concentration was normal in all 6 patients. The authors suppose that besides the already known pathogenetic factors, insufficient calcitonin effect and especially the partial lack of dehydroepiandrosterone-sulphate can play a role in the development of bone loss connected with iron overload. Further study with a greater number of patients is required to support the above findings.
Czink
E
E
National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
Horváth
C
C
Malek
A A
AA
Siklósi
G
G
D000328:Adult; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000209:etiology*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006432:Hemochromatosis / Q000150:complications / Q000209:etiology / Q000378:metabolism*; D006486:Hemosiderosis / Q000150:complications / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D007006:Hypogonadism / Q000209:etiology; D008297:Male; D008875:Middle Aged; D065227:Transfusion Reaction
D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate