Visual dysfunction in treated schizophrenia suggested by visual evoked potentials from pattern-reversal stimulation.
Steady-state visual evoked potentials (steady-state VEPs) from pattern-reversal stimulations were compared in treated schizophrenic patients and normal subjects matched for sex and age. The VEP amplitudes were more variable in the patients than in the controls. Furthermore, the VEP amplitudes of the patients mostly showed little or no change when the check size was varied, in contrast to the controls who showed a marked check size effect. These results suggest that schizophrenics receiving drugs have dysfunction of the visual system, especially an inability to respond adequately to changes of visual information.
Jibiki
I
I
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Takizawa
Y
Y
Yamaguchi
N
N
D000328:Adult; D001712:Biperiden / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D005074:Evoked Potentials, Visual / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009778:Occipital Lobe / Q000187:drug effects / Q000503:physiopathology; D010364:Pattern Recognition, Visual / Q000187:drug effects* / Q000502:physiology; D010775:Photic Stimulation; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology
D001712:Biperiden; D006220:Haloperidol