title: Minocycline-induced pigmentation occurring in two sisters.
abstract: Two sisters are described who developed facial pigmentation while on minocycline therapy for acne vulgaris. It is suggested that the possible mechanisms for this relatively uncommon complication occurring in these two patients may be due to either a genetically acquired alteration in metabolic handling of minocycline or to the ethinyloestradiol component of Dianette, which they were also receiving as treatment for their acne vulgaris. It is concluded that patients on minocycline should be regularly screened for signs of hyperpigmentation, especially if they are on other drugs which are known to accentuate pigmentation of skin.
authors.affiliation: Department of Dermatology, Royal Victoria Hospital, Belfast, Northern Ireland.
authors.forename: D J
authors.initials: DJ
authors.lastname: Eedy
authors.forename: D
authors.initials: D
authors.lastname: Burrows
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000235:genetics; D000293:Adolescent; D000726:Androgen Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D003534:Cyproterone / Q000009:adverse effects* / Q000627:therapeutic use; D017373:Cyproterone Acetate; D004338:Drug Combinations; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000009:adverse effects* / Q000627:therapeutic use; D005190:Family; D005260:Female; D006801:Humans; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use; D010859:Pigmentation Disorders / Q000139:chemically induced*; D012880:Skin Pigmentation / Q000235:genetics
chemical_list: D000726:Androgen Antagonists; D004338:Drug Combinations; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; C032640:Cyproterone acetate, ethinyl estradiol drug combination; D003534:Cyproterone; D008911:Minocycline