Heparin and platelet interactions influence alloantigen-induced proliferative responses of human T lymphocytes and immunoglobulin synthesis in vivo.
In contrast to defibrinated blood, cells isolated from heparinized blood give lower T-lymphoproliferative responses. Such responses can be also suppressed by addition of heparin to lymphocyte cultures. Platelets inhibit T cell proliferation and B cell differentiation, but their interactions with heparin may produce contrasting effects on different immune functions.
Górski
A
A
Department of Immunology, Transplantation Institute, Warsaw Medical School, Poland.
Wasik
M
M
Stepień-Sopniewska
B
B
Glapiński
T
T
D000917:Antibody Formation; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D007519:Isoantigens / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D007519:Isoantigens; D006493:Heparin