Human colostrum contains an activity that inhibits the production of IL-2.
The effect of human colostrum on T cell immune function was investigated. Colostrum inhibited the proliferation of human T cells activated by allogeneic, concanavalin A (Con A) or phytohaemagglutinin (PHA) stimulation. Colostrum also inhibited the production of IL-2 by Con A-activated human peripheral blood T cells and by Con A-activated Jurkat cells, a human T lymphoma line. Similarly, human colostrum inhibited the production of IL-2 by EL4 cells, a murine thymoma line, when stimulated with phorbol myristate acetate. The inhibitory activity was not cytotoxic and could not be neutralized by antibody to transforming human growth factor beta.
Hooton
J W
JW
Department of Biochemistry, Walter MacKenzie Center, University of Alberta, Edmonton, Canada.
Pabst
H F
HF
Spady
D W
DW
Paetkau
V
V
D002470:Cell Survival / Q000187:drug effects; D003126:Colostrum / Q000276:immunology*; D003208:Concanavalin A; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D037102:Lectins; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D016399:Lymphoma, T-Cell / Q000188:drug therapy; D010835:Phytohemagglutinins; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D013755:Tetradecanoylphorbol Acetate; D013945:Thymoma / Q000188:drug therapy; D013953:Thymus Neoplasms / Q000188:drug therapy; D016212:Transforming Growth Factor beta / Q000494:pharmacology
D007376:Interleukin-2; D037102:Lectins; D010835:Phytohemagglutinins; D016212:Transforming Growth Factor beta; D003208:Concanavalin A; D013755:Tetradecanoylphorbol Acetate