title: Lesions and localization of viral antigen in tissues of cattle with experimentally induced or naturally acquired mucosal disease, or with naturally acquired chronic bovine viral diarrhea.
abstract: Tissues from cattle that died of experimentally induced mucosal disease (n = 3), naturally acquired mucosal disease (n = 6), or naturally acquired chronic bovine viral diarrhea (n = 4) were examined. Consistent findings were lymphocytic depletion of lymphoid tissues, degeneration of myenteric ganglion cells, and mild adrenalitis. Intracytoplasmic viral antigen was detected in myenteric ganglia and in endocrine glandular cells. Noncytopathic virus was isolated from all cattle, and cytopathic virus was isolated from 12 of 13 cattle.
authors.affiliation: Department of Veterinary Pathology, Iowa State University, Ames 50011.
authors.forename: C L
authors.initials: CL
authors.lastname: Wilhelmsen
authors.forename: S R
authors.initials: SR
authors.lastname: Bolin
authors.forename: J F
authors.initials: JF
authors.lastname: Ridpath
authors.forename: N F
authors.initials: NF
authors.lastname: Cheville
authors.forename: J P
authors.initials: JP
authors.lastname: Kluge
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D002417:Cattle; D002908:Chronic Disease; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D008297:Male
chemical_list: D000956:Antigens, Viral