A meta-analysis of double-blind placebo-controlled trials of clonidine for smoking cessation.
Combined data from nine double-blind placebo-controlled trials (total n = 813), showed a smoking quit rate with clonidine that was significantly greater than with placebo. Further analysis suggested a potentiating influence of individual behavior therapy, and it appeared that clonidine may be more helpful for female than male smokers. Future trials are needed to determine long-term efficacy, and to clarify the effects of gender, other subject characteristics and various treatment conditions on the usefulness of clonidine as a smoking cessation aid.
Covey
L S
LS
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY.
Glassman
A H
AH
D003000:Clonidine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D012907:Smoking / Q000188:drug therapy*
D003000:Clonidine