title: Induction of diabetes by PolyI:C and anti-RT6.1 antibody treatment in DR-BB rats.
abstract: To determine whether environmental factors could affect the incidence of diabetes in RT6.1+ lymphocytes-depleted diabetes resistant (DR) BB rats, we tested polyinosinic-polycytidylic acid (Poly I:C), as an immune activator, in conjunction with anti-RT6.1 antibody in DR-BB rats which were bred in a specific pathogen free (SPF) condition. Diabetes was induced by the combined administration of poly I:C and anti-RT6.1 antibody. The use of poly I:C or anti-RT6.1 antibody alone did not cause diabetes. These results suggest that RT6.1+ T lymphocytes regulate autoimmune diabetes and that non-specific immune activation caused by environmental factors plays a key role in inducing diabetes in DR-BB rats.
authors.affiliation: First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: S
authors.initials: S
authors.lastname: Kimata
authors.forename: M
authors.initials: M
authors.lastname: Sawada
authors.forename: G
authors.initials: G
authors.lastname: Hasegawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: K
authors.initials: K
authors.lastname: Nakano
authors.forename: M
authors.initials: M
authors.lastname: Kondo
authors.forename: H
authors.initials: H
authors.lastname: Nakao
authors.forename: S
authors.initials: S
authors.lastname: Makino
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D004357:Drug Synergism; D005856:Germ-Free Life; D006649:Histocompatibility Antigens / Q000276:immunology*; D007518:Isoantibodies / Q000502:physiology; D011070:Poly I-C / Q000276:immunology*; D051381:Rats; D011913:Rats, Inbred BB; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D006649:Histocompatibility Antigens; D007518:Isoantibodies; C079330:RT6.1 antibody; C038353:histocompatibility antigens RT, rat; D011070:Poly I-C