title: New neplanocin analogues. Synthesis and antiviral activity of 6'-modified neplanocin A derivatives.
abstract: Novel neplanocin A analogues modified at the 6'-position, i.e. 6'-deoxy derivatives (2, 3, 5, 6, 14), 6'-O-methylneplanocin A (10) and 6'-C-methylneplanocin A (16a and 16b) were synthesized and evaluated for their antiviral activity in a wide variety of virus systems. Compound 16a (TJ-13025) surpassed neplanocin A both in antiviral potency and selectivity.
authors.affiliation: Exploratory Research Laboratory, Toyo Jozo Co., Ltd, Shizuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shuto
authors.forename: T
authors.initials: T
authors.lastname: Obara
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000998:Antiviral Agents; C031096:neplanocin A; D000241:Adenosine