title: Evaluation of local renal function in newborn infants under tobramycin therapy.
abstract: Aminoglycosides (AG) provided for less than 5 days to newborn infants do not produce a marked disturbance of glomerular filtration rate (creatinine clearance) or tubular sodium handling (fractional sodium excretion). However, transient disturbances of proximal tubular cell functions can be noted: the excretion of N-acetylglucosaminidase, a lysosomal enzyme, is elevated, and mature not premature infants show a decreased tubular reabsorption of low-molecular-weight proteins during AG treatment. Preliminary investigations show an increased excretion of villin, a structural protein of proximal tubular cells, and a decreased secretion of Tamm-Horsfall protein by the cells of ascending limb of Henle and early distal tubule.
authors.affiliation: Kinderklinik Albert-Ludwigs-Universität, Freiburg, FRG.
authors.forename: J U
authors.initials: JU
authors.lastname: Leititis
authors.forename: L B
authors.initials: LB
authors.lastname: Zimmerhackl
authors.forename: R
authors.initials: R
authors.lastname: Burghard
authors.forename: N
authors.initials: N
authors.lastname: Gordjani
authors.forename: M
authors.initials: M
authors.lastname: Brandis
mesh_terms: D000617:Aminoglycosides / Q000627:therapeutic use; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D009399:Nephrons / Q000187:drug effects / Q000502:physiology; D014031:Tobramycin / Q000627:therapeutic use*
chemical_list: D000617:Aminoglycosides; D014031:Tobramycin