Topical metronidazole gel. Use in acne vulgaris.
Two percent metronidazole and 5% benzoyl peroxide cream was evaluated in four clinical trials. It could be shown that this test cream was significantly better than 5% benzoyl peroxide jelly alone, and significantly better than a placebo cream. It was also shown that 2% metronidazole and 5% benzoyl peroxide cream was equal to systemic oxytetracycline therapy. The advisability of the combination of metronidazole and benzoyl peroxide was simultaneously discussed.
Gamborg Nielsen
P
P
Department of Dermatology, Varberg Hospital, Sweden.
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008889:Military Personnel; D010118:Oxytetracycline / Q000008:administration & dosage / Q000627:therapeutic use; D013607:Tablets; D016896:Treatment Outcome
D005782:Gels; D013607:Tablets; D008795:Metronidazole; D001585:Benzoyl Peroxide; D010118:Oxytetracycline