title: Incidence and management of secondary malignancies in patients with retinoblastoma and Ewing's sarcoma.
abstract: Childhood cancer survivors at highest risk of developing a secondary malignancy are those with hereditary retinoblastoma. The majority of such secondary cancers will be sarcomas, most commonly of bone. One-third of these occur outside a typical radiation field, commonly in an extremity. Bone sarcoma is also the most commonly reported secondary cancer to develop among survivors of Ewing's sarcoma. In this group, radiation doses greater than 60 Gy as well as alkylating agent chemotherapy have been identified as contributors to the increased risk. The prognosis for patients with a secondary sarcoma has been poor, with few cures reported to date. However, an aggressive, combined modality approach, including radical resection, postoperative radiation, and adjuvant chemotherapy, may improve the survival rate.
authors.affiliation: Department of Radiation Oncology, Stanford University Medical Center.
authors.forename: L M
authors.initials: LM
authors.lastname: Smith
authors.forename: S S
authors.initials: SS
authors.lastname: Donaldson
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000628:therapy; D002648:Child; D005134:Eye Neoplasms / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy; D016161:Genes, Retinoblastoma; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging / Q000473:pathology; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects; D012175:Retinoblastoma / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy