title: [Effect of intracerebroventricular administration of atrial natriuretic polypeptide on unit discharges of rat paraventricular nucleus].
abstract: We have applied microelectrode technique to record 118 spontaneously firing units from the hypothalamus in rats. Detection of the recording sites showed that 84 were in the paraventricular nucleus (PVN) and 34 were near the PVN (near-PVN). After intracerebroventricular (i.c.v.) administration of atrial natriuretic polypeptide (ANP), 91% (P less than 0.005) of the PVN neurones and 71% (P greater than 0.05) of near-PVN neurones sensitive to ANP showed a significant decrease in spontaneously firing rate. After i.c.v. administration of hypertonic NaCl solution, 64.7% (P less than 0.005) of the PVN neurones and 61.1% (P greater than 0.05) of near-PVN neurones showed a significant increase in firing rate. The results indicate that i.c.v. administration of ANP profoundly inhibits the electrical activity of the PVN neurones, but hypertonic NaCl solution markedly stimulates the PVN neurones.
authors.affiliation: Department of Physiology, Tianjin Medical College.
authors.forename: J S
authors.initials: JS
authors.lastname: Qi
authors.forename: J J
authors.initials: JJ
authors.lastname: Zhang
authors.forename: L Y
authors.initials: LY
authors.lastname: Ma
authors.forename: X D
authors.initials: XD
authors.lastname: Yang
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D004594:Electrophysiology; D007276:Injections, Intraventricular; D008297:Male; D008839:Microelectrodes; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009320:Atrial Natriuretic Factor