Neomycin does not interfere with the inositol phospholipid metabolism, but blocks binding of alpha-thrombin to intact human platelets.
Neomycin was demonstrated to inhibit the binding of thrombin to intact human platelets. The effects of neomycin on both thrombin binding and thrombin-induced changes in inositol phospholipid metabolism could be reproduced by the thrombin antagonist hirudin. We propose that neomycin inhibits thrombin-induced platelet activation by interference with the cellular receptor.
Tysnes
O B
OB
Department of Biochemistry, University of Bergen, Norway.
Johanessen
E
E
Steen
V M
VM
D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D009355:Neomycin / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000302:isolation & purification / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors; D018179:Receptors, Thrombin; D013917:Thrombin / Q000378:metabolism*
D010716:Phosphatidylinositols; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin; D013917:Thrombin; D009355:Neomycin