Reduction of murine cutaneous UVB-induced tumor-infiltrating T lymphocytes by dietary canthaxanthin.
The effect of dietary canthaxanthin, retinyl palmitate, or their combination on the tumor-infiltrating T-lymphocyte response (T-TIL) in de novo murine ultraviolet type B irradiation-induced tumors was investigated to elucidate potential mechanisms of action of these compounds. We found that dietary canthaxanthin greatly reduced the number of tumor-infiltrating helper/inducer, suppressor/cytotoxic, and interleukin-2 receptor-positive T lymphocytes and also observed a concomitant statistically significant increase in tumour incidence in canthaxanthin-fed animals. The addition of retinyl palmitate to the canthaxanthin diet ameliorated this negative effect on TIL and the development of skin tumors. We conclude that dietary retinyl palmitate and canthaxanthin can modulate the host T-cell immune response within a growing tumor and may affect tumorigenicity.
Rybski
J A
JA
Department of Pathology, University of Arizona College of Medicine, Tucson.
Grogan
T M
TM
Aickin
M
M
Gensler
H L
HL
D000818:Animals; D016644:Canthaxanthin / Q000008:administration & dosage*; D004032:Diet; D007958:Leukocyte Count; D016246:Lymphocytes, Tumor-Infiltrating / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D008809:Mice, Inbred C3H; D009381:Neoplasms, Radiation-Induced / Q000473:pathology; D012867:Skin / Q000166:cytology / Q000528:radiation effects; D012878:Skin Neoplasms / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology; D014466:Ultraviolet Rays
D016644:Canthaxanthin