Transient myeloproliferative disorder in Down's syndrome: three cases with megakaryocytic markers.
In this paper we describe three infants with Down's syndrome and transient myeloproliferative disorder. The blast cells of all three displayed positive megakaryocytic markers. One patient developed acute megakaryoblastic leukemia in his second year, with blasts identical to those of the initial episode. The other two cases remain well at 12 and 15 months of age.
Sartori
P C
PC
Department of Haematology, Birmingham Children's Hospital, United Kingdom.
Darbyshire
P J
PJ
D000015:Abnormalities, Multiple; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007947:Leukemia, Megakaryoblastic, Acute / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D009196:Myeloproliferative Disorders / Q000151:congenital* / Q000209:etiology / Q000473:pathology; D011289:Preleukemia / Q000209:etiology; D012074:Remission Induction
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D015415:Biomarkers