A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce.
Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include AMP, cGMP, ATP, inositol trisphosphate, and Ca2+. Channel current records obtained from larval muscle in different dunce mutants possessing abnormally high levels of cAMP show that, in the mutants, the channel displays an increased probability of opening.
Delgado
R
R
Centro de Estudios Cientificos de Santiago, Chile.
Hidalgo
P
P
Diaz
F
F
Latorre
R
R
Labarca
P
P
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology / Q000502:physiology*; D006152:Cyclic GMP / Q000494:pharmacology; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D007814:Larva; D008564:Membrane Potentials / Q000187:drug effects; D009132:Muscles / Q000502:physiology*; D009154:Mutation; D015221:Potassium Channels / Q000187:drug effects / Q000235:genetics / Q000502:physiology*
D015221:Potassium Channels; D015124:8-Bromo Cyclic Adenosine Monophosphate; D000242:Cyclic AMP; D006152:Cyclic GMP