Doxazosin in the treatment of mild or moderate essential hypertension: an echocardiographic study.
Sixteen patients with mild or moderate essential hypertension received 1 to 8 mg/day of doxazosin (mean daily dose, 2.7 mg). Blood pressure reduction (supine and standing) was highly significant (p less than 0.001), and no significant changes in heart rate were observed. A significant reduction (p less than 0.01) in left ventricular mass was seen without a change in left ventricular systolic function. All side effects were mild, and only one patient withdrew from the study.
Corral
J L
JL
Hypertension Unit, Central Hospital of Maracay, Estado Aragua, Venezuela.
López
N C
NC
Pecorelli
A
A
Rincón
L A
LA
Terán
V D
VD
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000000981:diagnostic imaging* / Q000188:drug therapy; D017292:Doxazosin; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D011224:Prazosin / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000959:Antihypertensive Agents; D017292:Doxazosin; D011224:Prazosin