[Recent advances of paraneoplastic neuromuscular syndromes].
Paraneoplastic neuromuscular syndromes reveal heterogeneous clinical features and often associate with particular tumor types. Patients presenting with one of the more distinctive syndromes, such as subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome, should undergo a careful search for detecting an occult malignancy. At present, an autoimmune pathogenesis has been clearly demonstrated only for the Lambert-Eaton syndrome. Specific autoantibodies in other syndromes may be diagnostic in identifying an underlying malignancy as a tumor marker. The precise role of antibodies in producing tissue damage and clinical manifestation is still controversial.
Sahashi
K
K
Fourth Department of Medicine, Aichi Medical University.
D002526:Cerebellar Diseases / Q000209:etiology; D003882:Dermatomyositis / Q000209:etiology; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology; D009443:Neuritis / Q000209:etiology; D009468:Neuromuscular Diseases / Q000209:etiology*; D010257:Paraneoplastic Syndromes; D015493:Paraparesis, Tropical Spastic / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000209:etiology