[Secretion of atrial natriuretic peptide and insulin in patients with kidney transplantation].
Influence of water immersion [WI] on atrial natriuretic peptide [ANP], insulin and glucose levels in kidney transplant patients [KTP] and healthy subjects [C] was observed. All KTP were divided on two groups - 35 patients treated by cyclosporine A+prednisone [CyA group] and 29 patients treated by azathioprine+prednisone [Aza group]. In all subjects plasma ANP, insulin and glucose levels were measured before and after 60 and 120 minutes of WI. KTP characterized a higher ANP level and lower insulin level than normals. WI induced statistically significant increase ANP and insulin levels and decrease glucose level in all groups. The increase ANP and IRI and decrease glucose were higher in healthy subjects. Only in healthy subjects a significant positive correlation were present between mean increase ANP and mean increase insulin and between mean increase ANP and mean decrease glucose level. Our results suggest lack of physiological relation between ANP and insulin. Kind of immunosuppressive therapy has only a minor influence on ANP and insulin changes during WI in KTP.
Zukqwska-Szczechowska
E
E
Klinika Nefrologii Slaskiej Akademii Medycznej.
Grzeszczak
W
W
Kokot
F
F
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D005260:Female; D006801:Humans; D007101:Immersion / Q000503:physiopathology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D012016:Reference Values
D007328:Insulin; D009320:Atrial Natriuretic Factor
Sekrecja przedsionkowego peptydu natriuretycznego i insuliny u chorych z przeszczepiona nerka.