title: [Determination of sex and Y chromosome].
abstract: Years of speculations about the nature of the elusive testis determining factor (TDF) of the Y chromosome have ended last year. A gene named SRY satisfies many criteria expected of the testis determining gene, and gives us a basis to understand molecular mechanisms of the testis differentiation. The different steps which gave rise to SRY cloning are described.
authors.affiliation: CRBM-CNRS UPR 8402, INSERM U 249, Montpellier.
authors.forename: F
authors.initials: F
authors.lastname: Poulat
authors.forename: P
authors.initials: P
authors.lastname: Berta
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics; D005796:Genes / Q000235:genetics; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D012732:Sex Determination Analysis; D012733:Sex Differentiation / Q000235:genetics; D014157:Transcription Factors; D014998:Y Chromosome / Q000648:ultrastructure*
chemical_list: D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C054430:ZFY protein, human
vernacular_title: Détermination du sexe et chromosome Y.