title: Sexually transmitted papilloma viral infection in the male. VII. Is cancer of penis sexually transmitted?
abstract: Four cases are reported of squamous cell carcinoma of the genital tract in males. The close association of HPV 16/18 with in situ squamous carcinoma affecting the penis is demonstrated. The first documented case of a primary penile squamous cell carcinoma with metastatic deposits yielding positive HPV 16/18 isolates as shown by in situ DNA hybridization again demonstrates a close association of this virus to malignancy in humans. The clinical implications of these findings strongly suggest that squamous cell carcinoma of the penis is a sexually transmitted disease. A thorough examination of both sexual partners is necessary when Bowenoid papulosis or penile carcinoma is present, since the female partner is at high risk for cervical neoplasia.
authors.affiliation: Department of Surgery, Sinai Hospital of Detroit, Michigan.
authors.forename: S K
authors.initials: SK
authors.lastname: Rosemberg
authors.forename: G
authors.initials: G
authors.lastname: Herman
authors.forename: E
authors.initials: E
authors.lastname: Elfont
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000382:microbiology*; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000302:isolation & purification*; D010412:Penile Neoplasms / Q000382:microbiology*; D014412:Tumor Virus Infections / Q000382:microbiology / Q000635:transmission*
chemical_list: D004279:DNA, Viral