Inhibition of tryptophan----niacin metabolism by dietary leucine and by leucine and 2-oxo-isocaproate in vitro.
Bender
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DA
Department of Biochemistry, University College London, UK.
D000818:Animals; D002478:Cells, Cultured; D003864:Depression, Chemical; D004044:Dietary Proteins / Q000494:pharmacology*; D007651:Keto Acids / Q000494:pharmacology*; D007737:Kynurenine / Q000031:analogs & derivatives / Q000378:metabolism; D007930:Leucine / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009249:NADP / Q000096:biosynthesis; D009525:Niacin / Q000096:biosynthesis*; D009536:Niacinamide / Q000031:analogs & derivatives / Q000096:biosynthesis; D010383:Pellagra / Q000139:chemically induced; D051381:Rats; D014364:Tryptophan / Q000378:metabolism*; D014977:Xanthurenates / Q000378:metabolism
D004044:Dietary Proteins; D007651:Keto Acids; D014977:Xanthurenates; D009536:Niacinamide; D009525:Niacin; C005045:3-hydroxykynurenine; D007737:Kynurenine; D009249:NADP; C028330:xanthurenic acid; C013082:alpha-ketoisocaproic acid; D014364:Tryptophan; D007930:Leucine; C008472:N-methylnicotinamide