title: Vulvar Paget disease: fluorescein-aided visualization of margins.
abstract: Two women with extramammary Paget disease of the vulva were given fluorescein intravenously in order to visualize disease margins with the use of an ultraviolet light. As a diagnostic modality, the technique was found to have a positive predictive value of 97.4% and a negative predictive value of 99.9%. The accuracy of the fluorescein technique was compared with gross visualization using a histologic mapping technique. A total of 2424 fields were mapped and the predictive accuracy of each test was determined. A chi 2 test demonstrated fluorescein visualization to be a significantly better predictor of a disease state. Fluorescein visualization is suggested as an adjunct to surgical management of patients with primary vulvar Paget disease.
authors.affiliation: Department of Obstetrics and Gynecology, Naval Hospital San Diego, California.
authors.forename: J E
authors.initials: JE
authors.lastname: Misas
authors.forename: C J
authors.initials: CJ
authors.lastname: Cold
authors.forename: F W
authors.initials: FW
authors.lastname: Hall
mesh_terms: D005260:Female; D019793:Fluorescein; D005452:Fluoresceins; D006801:Humans; D010145:Paget Disease, Extramammary / Q000473:pathology* / Q000601:surgery; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D005452:Fluoresceins; D019793:Fluorescein