T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor.
The antigen receptor repertoire is conditioned by discriminating forces in the thymus. Cells that see antigen only in the context of self major histocompatibility gene products are positively selected and those that recognize self antigens are deleted. The molecular mechanisms by which this complex conditioning is achieved via a single antigen receptor is one of the most fascinating problems in immunology. Here Terri Helman Finkel and colleagues review the literature and present a unifying mechanistic model of this process.
Finkel
T H
TH
National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Kubo
R T
RT
Cambier
J C
JC
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D017252:CD3 Complex; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens; D002118:Calcium / Q000502:physiology; D002454:Cell Differentiation; D006649:Histocompatibility Antigens / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D051379:Mice; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000502:physiology*; D012641:Selection, Genetic; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D001324:Autoantigens; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D006649:Histocompatibility Antigens; D011518:Proto-Oncogene Proteins; D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases; D002118:Calcium