title: Selenium in human mammary carcinogenesis: a case-referent study.
abstract: In a case-referent study on the possible role of selenium in human mammary carcinogenesis, serum selenium was found to be 79 +/- 12 micrograms/l in 66 cases and 81 +/- 12 micrograms/l in 93 referents. An internal trend in serum selenium was observed among cases (TNM stage I 81 +/- 11 micrograms/l and TNM stage II 76 +/- 13 micrograms selenium/l), indicating disease-mediated changes. The evaluation of selenium as a risk indicator in human breast cancer was therefore restricted to TNM stage I patients (n = 36). Multiple logistic regression analyses including variables associated with selenium levels revealed no association between selenium levels and breast cancer risk.
authors.affiliation: Institute of Social Medicine, University of Aarhus, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Overvad
authors.forename: P
authors.initials: P
authors.lastname: Grøn
authors.forename: O
authors.initials: O
authors.lastname: Langhoff
authors.forename: U
authors.initials: U
authors.lastname: Tarp
authors.forename: A
authors.initials: A
authors.lastname: Foldspang
authors.forename: E B
authors.initials: EB
authors.lastname: Thorling
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology; D000328:Adult; D000367:Age Factors; D000368:Aged; D001835:Body Weight; D001943:Breast Neoplasms / Q000097:blood* / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009367:Neoplasm Staging; D012307:Risk Factors; D012643:Selenium / Q000097:blood*; D012709:Serum Albumin / Q000032:analysis; D012907:Smoking
chemical_list: D012709:Serum Albumin; D012643:Selenium