title: Modern chemotherapeutic regimens in the management of aggressive non-Hodgkin lymphoma: can they be improved?
abstract: Major advances in the treatment of aggressive NHL have occurred in the last 20 years. Modern combination chemotherapy provides a complete remission in a majority of patients and cures a significant number of these patients. Treatment failures are a consequence of the existence or development of resistant disease and regimen related toxicity. Identification of mechanisms of tumour resistance and prognostic factors, together with consideration of regimen related toxicity, should aid in the optimal application of currently available agents and regimens and guide the development of future regimens. Novel delivery systems may allow more tumour specific therapy in the future.
authors.affiliation: Department of Hematology and Oncology, University of Nebraska Medical Center, Omaha 68198-3330.
authors.forename: D J
authors.initials: DJ
authors.lastname: Inwards
authors.forename: J O
authors.initials: JO
authors.lastname: Armitage
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis