Selecting combinations of chemotherapeutic drugs to maximize dose intensity.
A mathematical model is described for selecting combinations of chemotherapeutic drugs in order to maximize antitumor dose intensity subject to constraints on toxicity to normal organ systems. Determination of which drugs to combine and in what proportions to combine them offers combinatorially huge numbers of possibilities. The method described here offers one approach to identifying combinations worthy of evaluation in prospective comparative clinical trials.
Simon
R
R
Biometric Research Branch, National Cancer Institute, Bethesda, Maryland.
Korn
E L
EL
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods / Q000706:statistics & numerical data; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D015233:Models, Statistical; D011446:Prospective Studies