title: Antibiotic resistance of Clostridium difficile isolates.
abstract: The activity of metronidazole, vancomycin, clindamycin and teicoplanin against Clostridium difficile strains isolated from various origins in Poland was investigated. MIC was determined for metronidazole, clindamycin and teicoplanin. The disc-diffusion method was used for the vancomycin susceptibility test. Three out of thirty-eight strains were resistant to vancomycin and twenty-eight were susceptible to teicoplanin. A widespread MIC was observed for clindamycin and metronidazole. No correlation between the origin of the strain, toxigenicity and susceptibility to teicoplanin, clindamycin, vancomycin and metronidazole was evident.
authors.affiliation: Department of Bacteriology and Immunology, Medical Academy, Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Dworczyński
authors.forename: B
authors.initials: B
authors.lastname: Sokół
authors.forename: F
authors.initials: F
authors.lastname: Meisel-Mikołajczyk
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents; D002648:Child; D002675:Child, Preschool; D002981:Clindamycin / Q000494:pharmacology; D016360:Clostridioides difficile / Q000187:drug effects* / Q000302:isolation & purification; D003967:Diarrhea / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006020:Glycopeptides / Q000494:pharmacology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000382:microbiology; D008795:Metronidazole / Q000494:pharmacology; D011044:Poland; D017334:Teicoplanin; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D008795:Metronidazole; D002981:Clindamycin; D017334:Teicoplanin; D014640:Vancomycin