title: Immediate and delayed allergy from epoxy resins based on diglycidyl ether of bisphenol A.
abstract: This case report presents two patients with immediate and delayed allergy to epoxy resins based on diglycidyl ether of bisphenol A (DGEBA). In patch testing, the epoxy resin (DGEBA-based) of the standard series gave allergic reactions. Both patients had a prick test reaction of histamine size or larger to the human serum albumin (HSA) conjugate of DGEBA-based epoxy resins. One had been occupationally exposed to methyl tetrahydrophthalic anhydride (MTHPA) and had a histamine-size prick test reaction to the HSA conjugate of MTHPA; the other did not react to the conjugate. Determinations of specific immunoglobulin E were carried out with HSA-DGEBA conjugates, two DGEBA-based epoxy resins, and phthalic anhydrides. The first patient had positive tests to DGEBA, the DGEBA-based epoxy resins, and two phthalic anhydrides, and the second to DGEBA and the DGEBA-based epoxy resins, but not to the phthalic anhydrides.
authors.affiliation: Institute of Occupational Health, Helsinki, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Kanerva
authors.forename: R
authors.initials: R
authors.lastname: Jolanki
authors.forename: O
authors.initials: O
authors.lastname: Tupasela
authors.forename: L
authors.initials: L
authors.lastname: Halmepuro
authors.forename: H
authors.initials: H
authors.lastname: Keskinen
authors.forename: T
authors.initials: T
authors.lastname: Estlander
authors.forename: M L
authors.initials: ML
authors.lastname: Sysilampi
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D009783:Dermatitis, Occupational / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D004852:Epoxy Compounds / Q000276:immunology; D004853:Epoxy Resins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010796:Phthalic Anhydrides / Q000276:immunology; D012882:Skin Tests; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004852:Epoxy Compounds; D004853:Epoxy Resins; D007073:Immunoglobulin E; D010796:Phthalic Anhydrides; C019273:bisphenol A diglycidyl ether; D000098826:Bisphenol A Compounds