title: The beta-adrenergic signaling pathway in the heart.
abstract: Postsynaptic defects in this important pathway for regulating heart rate and contractile force may contribute to the etiology and pathogenesis of congestive cardiac failure. Such defects may involve the beta-adrenergic receptor, its associated G protein, or adenylate cyclase. Current knowledge about these components of transmembrane cardiac signaling is reviewed.
authors.affiliation: Harvard Medical School, Boston.
authors.forename: C J
authors.initials: CJ
authors.lastname: Homcy
mesh_terms: D000262:Adenylyl Cyclases / Q000502:physiology; D003327:Coronary Disease / Q000209:etiology / Q000503:physiopathology; D000242:Cyclic AMP / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases