[Interactions and biological mechanisms of action of molecular signal peptides. I. Interleukin 1 (IL-1)].
Interleukin 1 (IL-1) has several fundamental immunoregulatory, haematological, metabolic and physiological effects. It coordinates the different cellular interactions in wound healing and inflammation, but most importantly it stimulates the activation and differentiation of pre-B-cells and T-cells, the attraction of neutrophils, the recruitment of bone marrow stem cells, the stimulation of the metabolism of arachnoid acid, the degradation of proteoglycans, an increase of body temperature and loss of appetite. An altered production of IL-1 or of IL-1 inhibitors may cause profound disturbances, as in AIDS, other viral and malignant diseases and in uncontrolled inflammatory processes. Since a variety of feedback mechanisms for the stimulation or inhibition of IL-1 production have been detected, a major research goal will be to analyse and correct as curly as possible any abnormalities of inflammation or wound healing. Completely new treatment methods might become available in the future through approaches interfering with the signal transduction or processing of IL-1, especially by IL-1 receptor antagonists (IL-1RA).
Wustrow
T P
TP
Klinik und Poliklinik für Hals-Nasen-Ohrenkranke Ludwig-Maximilians-Universität, Klinikum Grosshadern.
D000818:Animals; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D007375:Interleukin-1 / Q000502:physiology* / Q000627:therapeutic use; D021382:Protein Sorting Signals / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology*; D017472:Receptors, Interleukin-1; D015398:Signal Transduction / Q000502:physiology*
D007375:Interleukin-1; D021382:Protein Sorting Signals; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1
Interaktionen und biologische Wirkungsmechanismen von molekularen Signalpeptiden. I. Interleukin 1 (IL-1).