[ATPase activity of rat brain microsomal and synaptosomal fractions in insulin hypoglycemia and its treatment with glucose].
Experiments on albino rats were made to investigate the activity of Na+, K(+)-ATPase and Mg(2+)-ATPase of fractions of microsomes and nerve endings, isolated from the cortex of the cerebral hemispheres, subcortical structures and medulla oblongata. The brain of healthy animals and that of rats in the state of insulin coma (40 units/kg of the hormone intramuscularly) were investigated at various periods after coma arrest with glucose. It has been assumed that an increase in the number of active molecules of Na+, K(+)-ATPase under the influence of structural changes of membranes in hypoglycemia cannot provide the electric activity of neurons in the absence of glycolytic ATP in neuroglycopenia.
Filippov
S P
SP
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D005947:Glucose / Q000627:therapeutic use*; D007003:Hypoglycemia / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D007331:Insulin Coma / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D051381:Rats; D013574:Synaptosomes / Q000201:enzymology*
D000251:Adenosine Triphosphatases; D005947:Glucose
ATFaznaia aktivnost' mikrosomal'noĭ i sinaptosomal'noĭ fraktsiĭ otdelov mozga krys pri insulinovoĭ gipoglikemii i ee kupirovanii gliukozoĭ.