The status of rotavirus vaccines in 1990.
The status of rotavirus (RV) vaccines in 1990 is reviewed with particular reference to the range of RV strains which infect human beings as well as the antibody response and immunity to naturally acquired RV infections. The requirements for an ideal vaccine are stated and the various approaches towards developing RV vaccines are described. Results of various field trials are given and finally important questions are posed which remain to be addressed if success in producing an ideal vaccine is to be achieved.
Haffejee
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Department of Paediatrics and Child Health, Faculty of Medicine, University of Natal, Durban, South Africa.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D006801:Humans; D012401:Rotavirus / Q000145:classification / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology*; D022243:Rotavirus Vaccines; D013045:Species Specificity; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology* / Q000302:isolation & purification
D000914:Antibodies, Viral; C041165:RIT 4237 vaccine; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; C058442:WC3 rotavirus vaccine; C052014:rhesus rotavirus vaccine