title: Sequences of four previously undescribed human T-cell receptor beta chain variable genes.
abstract: T-cell receptor beta chain mRNA from 4 human T-lymphocyte clones was reverse transcribed, amplified by PCR, cloned in M13 and sequenced. Four hitherto undescribed variable genes were found. One of them (V beta-IW22) showed the highest homology (74.5%) to V beta 1. Two others (V beta-IW6 and V beta-IW10) belonged to the recently described V beta 21 family. The last gene (V beta-VW114) belonged to the V beta 9 family. However, the latter gene a is pseudogene because of an in-frame stop codon.
authors.affiliation: Institute of Transplantation Immunology, National Hospital, Oslo, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Hansen
authors.forename: E
authors.initials: E
authors.lastname: Qvigstad
authors.forename: K E
authors.initials: KE
authors.lastname: Lundin
authors.forename: E
authors.initials: E
authors.lastname: Thorsby
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002999:Clone Cells; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D013601:T-Lymphocytes
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta