Signal transduction in eukaryotic cells and intracellular parasitism of Legionella.
A fundamental property of the eukaryotic cell is its ability to respond to external signals. This property becomes extremely important during microbial invasion, when the volume of information to be analyzed by the cellular receptor machinery increases considerably. Cell-surface receptors are influenced by a pool of additional ligands, some of the most important of these being the infecting microorganism, products of bacterial metabolism, virulence factors, as well as regulators produced by the endocrine and immune systems of the infected animal (e.g. antibodies, hormones, lymphokines, and mediators of inflammatory responses). The consequence of the binding of ligands is the activation of different antibacterial mechanisms, some of which are used by the phagocytes after ingestion of the infectious agent. Inhibition of such antibacterial mechanisms by intruding microorganisms could be achieved by bacterially-induced alterations in signal transduction.
Belyi YuF
N F Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.
Tartakovskii
I S
IS
Vertiev YuV
Prosorovskii
S V
SV
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D007875:Legionella / Q000502:physiology*; D007876:Legionellosis / Q000276:immunology* / Q000382:microbiology; D010586:Phagocytes / Q000276:immunology* / Q000382:microbiology; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction
D011506:Proteins; D011494:Protein Kinases; D019204:GTP-Binding Proteins