Down syndrome and sleep apnea--a therapeutic challenge.
This case report describes 3 patients with Down syndrome and obstructive breathing problems, ages: 5 months, 15 months, and 22 years. The youngest one had normal cardiopulmonary function at birth, but soon developed a pulmonary hypertension. The next had a severe atrioventricular defect and additional pulmonary hypertension and there was little hope for her to survive heart surgery. The oldest one had had apneas since childhood with increasing severity, but was regarded as having normal heart function. All 3 were operated to relieve their breathing obstruction. The 5-month-old boy improved only slightly after an initial UPPP and had to be tracheotomized, which solved his problems. The tracheotomy could be removed when he was one year. The 15-month-old girl was cured of her breathing problems through an A + T and survived her heart surgery one month later. Tonsillectomy and UPPP was performed on the oldest patient. Following surgery, he had an episode of life-threatening bleeding and developed a DIC syndrome, and was critically ill for 18 days. After he recovered, his sleep apnea had improved. Once a myxoedema was diagnosed and treated, he made further progress. These cases stress the significance of early recognition of sleep apnea in children with Down syndrome and the importance of a careful preoperative investigation in collaboration with cardiologists.
Hultcrantz
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Department of Otorhinolaryngology, University Hospital, Uppsala, Sweden.
Svanholm
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D000233:Adenoidectomy; D000328:Adult; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010160:Palate, Soft / Q000601:surgery; D010614:Pharynx / Q000601:surgery; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000601:surgery*; D014068:Tonsillectomy; D014140:Tracheotomy; D014609:Uvula / Q000601:surgery