title: Antiproliferative activity of retinoids, interferon alpha and their combination in five human transformed cell lines.
abstract: Tretinoin, isotretinoin and acitretin were examined for their capacity to modulate the proliferation of the cell lines: HL-60 (acute promyelocytic leukemia), MCF7 (mammary carcinoma), SCC4, SCC15 and A431 (squamous cell carcinomas). Retinoids inhibited proliferation to a varying extent in all 5 cell lines. The cytokine IFN alpha had a significant antiproliferative effect only on HL-60, SCC4 and SCC15. The combination of retinoids with IFN alpha led in all 5 cell lines to a more profound reduction in proliferation than either retinoids or IFN alpha alone.
authors.affiliation: Pharmaceutical Research, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
authors.forename: J R
authors.initials: JR
authors.lastname: Frey
authors.forename: R
authors.initials: R
authors.lastname: Peck
authors.forename: W
authors.initials: W
authors.lastname: Bollag
mesh_terms: D017255:Acitretin; D002455:Cell Division / Q000187:drug effects*; D004357:Drug Synergism; D006131:Growth Inhibitors; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000008:administration & dosage*; D015474:Isotretinoin / Q000494:pharmacology; D012176:Retinoids / Q000008:administration & dosage*; D014212:Tretinoin / Q000031:analogs & derivatives / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D006131:Growth Inhibitors; D007370:Interferon Type I; D012176:Retinoids; D014212:Tretinoin; D015474:Isotretinoin; D017255:Acitretin