[The mitostatic and lymphotoxic action of kemantane and its effect on B-suppressors].
The in vivo study of the influence of Kemantan on the growth of endogenous colonies in the spleen of sublethally (6 Gy) irradiated (CBA x C57BL/6J) F1 mice (mitostatic action) and on the capacity of transplanted lymphocytes of CBA mice for suppressing their multiplication (lymphotoxic action) was carried out. Besides the capacity of Kemantan for affecting the induction, formation and functioning of B-suppressors of antibody formation was studied. As revealed in this study, Kemantan in doses of 0.2-200 mg/kg did not produce a mitostatic and lymphotoxic effect and had no influence on the realization of the suppressing action of mature B-suppressors. In doses of 20 and 200 mr/kg Kemantan, injected to donors at the phase of the induction and accumulation of B-suppressors, abolished their formation.
Man'ko
V M
VM
Pinegin
B V
BV
Rudneva
T B
TB
Blagonravova
O L
OL
Artsimovich
N G
NG
Gadzhiev
R I
RI
D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008938:Mitosis / Q000187:drug effects*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D013601:T-Lymphocytes / Q000187:drug effects* / Q000528:radiation effects / Q000637:transplantation; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects
D000276:Adjuvants, Immunologic; C068220:kemantane; D000218:Adamantane
Mitostaticheskoe i limfotoksicheskoe deĭstvie kemantana i ego vliianie na B-supressory.