title: Protection of rats against dental caries by passive immunization with hen-egg-yolk antibody (IgY).
abstract: Hen-egg-yolk antibody (IgY) was prepared against Streptococcus mutans MT8148 serotype c that was cultivated in medium containing sucrose, and it was used in passive caries-immunity studies. Specific pathogen-free rats infected with S. mutans MT8148 (c) and fed with a cariogenic diet containing more than 2% immune yolk powder developed significantly lower caries scores than did the ones infected with the same strain and fed with a diet containing only control yolk powder obtained from non-immunized hens. Similar results were obtained in an experiment with rats infected with S. mutans JC-2 (c) strain. Rats provided a diet supplemented with 0.5% immune water-soluble protein fraction containing S. mutans-specific IgY and challenged with S. mutans MT8148 exhibited significantly fewer caries lesions, compared with control rats on the normal diet.
authors.affiliation: Department of Clinical Pathology, Nihon University School of Dentistry, Chiba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Otake
authors.forename: Y
authors.initials: Y
authors.lastname: Nishihara
authors.forename: M
authors.initials: M
authors.lastname: Makimura
authors.forename: H
authors.initials: H
authors.lastname: Hatta
authors.forename: M
authors.initials: M
authors.lastname: Kim
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Hirasawa
mesh_terms: D000284:Administration, Oral; D000372:Agglutination Tests; D000818:Animals; D002645:Chickens; D003731:Dental Caries / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004527:Egg Proteins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D007116:Immunization, Passive / Q000379:methods*; D007136:Immunoglobulins / Q000008:administration & dosage / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013047:Specific Pathogen-Free Organisms; D013295:Streptococcus mutans / Q000276:immunology
chemical_list: D004527:Egg Proteins; C016512:IgY; D007136:Immunoglobulins