Effects of thymoxamine on corneal endothelium.
We have investigated the effects of 0.02 and 0.2% thymoxamine hydrochloride on the isolated rabbit corneal endothelium. The corneal swelling rate, measured by specular microscopy, indicated that 0.02% thymoxamine caused a swelling rate equal to controls while a 0.2% concentration caused a significantly increased swelling rate (34.1 vs 10.3 microns/h; P less than 0.05). The data suggests that the maximum recommended intracameral concentration of thymoxamine be 0.02% in order to allow a 10-fold safety factor for the corneal endothelium.
Green
K
K
Department of Ophthalmology, Medical College of Georgia, Augusta 30912-3400.
Chapman
J M
JM
Cheeks
L
L
Hull
D S
DS
D000818:Animals; D015715:Corneal Edema / Q000473:pathology; D004728:Endothelium, Corneal / Q000187:drug effects* / Q000473:pathology; D005260:Female; D008297:Male; D013948:Moxisylyte / Q000633:toxicity*; D010477:Perfusion; D011817:Rabbits
D013948:Moxisylyte