title: [Sedation with flunitrazepam and its antagonism with flumazenil in endoscopic urological procedures: our clinical experience].
abstract: Patients, especially males, do not easily stand endoscopic urological diagnostic examinations. So flunitrazepam (0.01 mg/kg IV) has been used to insure a suitable sedation. At the end of such examination flumazenil, a selective benzodiazepine antagonist has been injected. The levels of sedation and orientation so obtained and the cardiorespiratory parameters have been collected during a one hour follow-up from the intravenous injection of the antagonist. This method presents minimal side effects (a marginal, but statistically significative, systolic arterial pressure reduction), a completely normal coordination of movements and awareness of space and time relationship at the end of the observation period. Therefore it is a very good solution for short time examinations giving the chance to safely and shortly dismiss the patient.
authors.affiliation: Istituto di Anestesia e Rianimazione, Università degli Studi di Milano.
authors.forename: R
authors.initials: R
authors.lastname: Russo
authors.forename: R
authors.initials: R
authors.lastname: Ravagnan
authors.forename: G
authors.initials: G
authors.lastname: Veschi
authors.forename: E
authors.initials: E
authors.lastname: Dellino
authors.forename: M R
authors.initials: MR
authors.lastname: Aveni
authors.forename: V
authors.initials: V
authors.lastname: Buzzetti
authors.forename: G
authors.initials: G
authors.lastname: Dormia
authors.forename: E
authors.initials: E
authors.lastname: Patelli
authors.forename: G
authors.initials: G
authors.lastname: Gonnella
authors.forename: G
authors.initials: G
authors.lastname: Iapichino
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D016292:Procedural Sedation; D003243:Consciousness / Q000187:drug effects; D003558:Cystoscopy; D005260:Female; D005442:Flumazenil / Q000494:pharmacology / Q000627:therapeutic use*; D005445:Flunitrazepam / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000601:surgery
chemical_list: D006993:Hypnotics and Sedatives; D005442:Flumazenil; D005445:Flunitrazepam
vernacular_title: Sedazione con flunitrazepam e suo antagonismo con flumazenil nelle procedure urologiche endoscopiche: nostra esperienza clinica.