[The proteinase inhibitors of mixed saliva in periodontitis].
Activities of cysteine and trypsin-like proteinase inhibitors and of cathepsin D were measured in mixed saliva of periodontitis patients with conditions of varying severity. Salivary proteinase inhibitor activities were found related, to a certain measure, to the severity of inflammation. Salivary antitryptic activity was somewhat reduced and cysteine proteinase inhibitor activity elevated in patients with non-severe periodontitis. In cases with medium-severe and severe periodontitis salivary proteinase activity was augmenting, approaching the normal value, whereas cysteine proteinase inhibitor level was significantly decreased. A reduction of salivary inhibitor activity was related to the formation of inhibitor-proteinase complexes, whereas a rise of this activity was explained by release of inhibitors from these complexes resulting from dissociation. This is possibly due to the formation of partially cleaved inhibitor form because of cathepsin effects.
Vavilova
T P
TP
Tolmacheva
I I
II
D000293:Adolescent; D000328:Adult; D002402:Cathepsin D / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D010518:Periodontitis / Q000201:enzymology*; D011480:Protease Inhibitors / Q000032:analysis*; D012463:Saliva / Q000737:chemistry / Q000201:enzymology*; D014357:Trypsin / Q000032:analysis
D011480:Protease Inhibitors; D014357:Trypsin; D002402:Cathepsin D
Ingibitory proteinaz smeshannoĭ sliuny pri parodontite.