Synthesis and nuclease susceptibility of alpha-oligodeoxyribonucleotide phosphorothioate.
Novel DNA analog, alpha-2'-deoxyoligothymidylate phosphorothioate was conveniently synthesized via phosphoramidite solid support method. The non natural DNA analog showed enhanced stability toward enzymatic degradation.
Shinozuka
K
K
Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu City, Japan.
Morita
T
T
Sawai
H
H
D002851:Chromatography, High Pressure Liquid; D003851:Deoxyribonucleases / Q000378:metabolism*; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000378:metabolism; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D013938:Thymidine Monophosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism
D009838:Oligodeoxyribonucleotides; D013873:Thionucleotides; C077887:alpha-2'-deoxyoctathymidylate phosphorothioate; D013938:Thymidine Monophosphate; D003851:Deoxyribonucleases