Cytochrome c oxidase subunit II mRNA levels during T-lymphocyte proliferation and liver regeneration.
We studied here the variations in the mRNA levels of the mitochondrially-encoded subunit II of cytochrome c oxidase (COII) during the proliferation of thymocytes, splenic T-cells and hepatocytes. The COII mRNA levels increased during thymocyte proliferation and decreased when they were growth arrested. However, its levels remained nearly constant during splenic T-cell proliferation and liver regeneration after partial hepatectomy. The different pattern of COII gene expression in the cellular systems analyzed suggests that an increment in the oxidative metabolism could not always be necessary during cell proliferation.
Otero
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Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad de Santiago de Compostela, Galicia, Spain.
Bustelo
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Gómez-Márquez
J
J
D000818:Animals; D002455:Cell Division; D003576:Electron Transport Complex IV / Q000235:genetics*; D015870:Gene Expression; D006498:Hepatectomy; D008099:Liver / Q000201:enzymology; D008115:Liver Regeneration; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology* / Q000201:enzymology
D012333:RNA, Messenger; D003576:Electron Transport Complex IV