[The efficacy and side effects of chemotherapy for primary lung cancer with cisplatin and etoposide].
We treated 34 primary lung cancer patients with chemotherapy of cisplatin and etoposide. There were 2 cases of CR (15%) and 8 cases of PR (61%) out of 13 cases of small cell lung cancer. No case of CR and one case of PR (5%) were obtained out of 21 cases of non-small cell cancer. Side effects were leukopenia, increase of BUN and creatinine, angina pectoris, supraventricular premature contraction, and renal failure. WBC reached nadir on day 15 on average. When we repeated this regimen, we encountered 3 cases of acute myocardial infarction, and it was useful for small cell lung cancer.
Tsutsumi
T
T
Department of Respiratory Medicine, Kyoto National Hospital, Fushimi-ku, Japan.
Kawakami
A
A
Ozawa
Y
Y
Kawaguchi
H
H
Fujii
H
H
Sawano
T
T
Asamoto
H
H
D000230:Adenocarcinoma / Q000188:drug therapy; D000284:Administration, Oral; D000787:Angina Pectoris / Q000139:chemically induced; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004341:Drug Evaluation; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects; D007970:Leukopenia / Q000139:chemically induced; D008175:Lung Neoplasms / Q000188:drug therapy*
D005047:Etoposide; D002945:Cisplatin