Bone induction by composite of bioerodible polyorthoester and demineralized bone matrix in rats.
A composite of a local, sustained, drug-release system, Alzamer bioerodible polyorthoester, and demineralized bone-matrix (DBM) particles implanted in the abdominal muscle of 89 Wistar rats induced cartilage and bone formation at the same rate as DBM when evaluated histologically and by 85Sr uptake. The composite implant was technically easier to use than DBM alone.
Pinholt
E M
EM
Institute for Surgical Research, Rikshospitalet, University of Oslo, Norway.
Solheim
E
E
Bang
G
G
Sudmann
E
E
D000009:Abdominal Muscles / Q000601:surgery; D000818:Animals; D001857:Bone Matrix / Q000166:cytology / Q000502:physiology* / Q000637:transplantation; D005663:Furans / Q000494:pharmacology*; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D011091:Polyesters / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013326:Strontium Radioisotopes
D005663:Furans; D011091:Polyesters; D013326:Strontium Radioisotopes; C045986:Alzamer