[Effects of eugenol and derivatives on Biomphalaria glabrata].
Biomphalaria glabrata snails and egg-masses were exposed, for six to twenty-four hours to concentrations of 1, 10, 100 and 1000 ppm of Eugenol, O-methyleugenol, O-benzyleugenol and dehydrodieugenol. Only at 10 ppm O-benzyleugenol enhanced mortality of snails and egg-masses. The other substances showed ovicidal and molluscicidal activity only at 100 and 1000 ppm concentrations, causing a significant cardiac frequency reduction in snails after 6 to 24 hours of exposure as well as perduring low cardiac rates until 24 hours afterwards. Two specimen exposed to 100 ppm O-methyleugenol presented anesthetic effect and extrusion of copulator and urethral organs. No schistosomicide or anesthetic effects were observed in mice experimentally infected with Schistosoma mansoni and treated during 5 days with oral doses of 150 mg/kg of Eugenol, O-methyleugenol and O-benzyleugenol.
De Souza
C P
CP
Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brasil.
De Oliveira
A B
AB
Araújo
N
N
Katz
N
N
D000284:Administration, Oral; D000818:Animals; D001700:Biomphalaria / Q000187:drug effects*; D005054:Eugenol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D051379:Mice; D010063:Ovum / Q000187:drug effects*; D012550:Schistosoma mansoni / Q000187:drug effects; D013997:Time Factors
D005054:Eugenol
Efeitos do eugenol e derivados sobre Biomphalaria glabrata.