title: [Alpha 1-antitrypsin and its phenotype in patients with asthma and aspirin hypersensitivity].
abstract: Alpha-1 antitrypsin (A-1-AT) levels were determined in 46 patients with aspirin sensitive asthma using the Eriksson method. The control group was made up of 17 asthmatics without aspirin sensitivity and 78 healthy volunteers. In 30 patients with aspirin asthma the phenotype of A-1-AT was determined using the Laurell method. The serum A-1-AT level was significantly higher in asthmatics in comparison with the healthy subjects. In the 30 subjects in whom the phenotype of A-1-AT was determined none of the phenotypes characteristic for lowered A-1-AT level were found more frequently than in groups without sensitivity to aspirin.
authors.affiliation: Kliniki Pneumonologii i Alergologii Akademii Medycznej w Lodzi.
authors.forename: M
authors.initials: M
authors.lastname: Szmidt
authors.forename: I
authors.initials: I
authors.lastname: Grzelewska-Rzymowska
authors.forename: M L
authors.initials: ML
authors.lastname: Kowalski
authors.forename: J
authors.initials: J
authors.lastname: Rozniecki
mesh_terms: D000328:Adult; D001241:Aspirin / Q000276:immunology*; D001249:Asthma / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics; D001980:Bronchi / Q000187:drug effects / Q000201:enzymology*; D001985:Bronchial Provocation Tests / Q000379:methods; D004342:Drug Hypersensitivity / Q000150:complications / Q000175:diagnosis / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D012016:Reference Values; D000515:alpha 1-Antitrypsin / Q000032:analysis* / Q000235:genetics; D019896:alpha 1-Antitrypsin Deficiency
chemical_list: D000515:alpha 1-Antitrypsin; D001241:Aspirin
vernacular_title: Zachowanie sie alfa-1-antytrypsyny oraz jej fenotypy u chorych na astme z nadwrazliwościa na aspiryne.