title: [Hypoglycemia induced by cibenzoline in the elderly].
abstract: Hypoglycaemia induced by class IA antiarrhythmic agents has been described. A case of cibenzoline-induced hypoglycaemia with favourable outcome is reported. The patient's age (84 years), increased renal impairment and malnutrition acted as facilitating factors. Blood insulin levels were normal in both absolute and relative values. Therapeutic overdosage in relation to age and renal function has been found in 20 out of 24 cases published or recorded by the French pharmacovigilance system. The mechanism of this hypoglycaemia is uncertain; absolute or relative hyperinsulinism has been detected in only 5 out of 14 controlled cases.
authors.affiliation: Clinique Médicale B, CHRU de ROUEN, Hôpital de Bois-Guillaume.
authors.forename: C
authors.initials: C
authors.lastname: Houdent
authors.forename: C
authors.initials: C
authors.lastname: Noblet
authors.forename: C
authors.initials: C
authors.lastname: Vandoren
authors.forename: H
authors.initials: H
authors.lastname: Levesque
authors.forename: C
authors.initials: C
authors.lastname: Morin
authors.forename: N
authors.initials: N
authors.lastname: Moore
authors.forename: H
authors.initials: H
authors.lastname: Courtois
authors.forename: L M
authors.initials: LM
authors.lastname: Wolf
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007093:Imidazoles / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; C032151:cifenline
vernacular_title: Hypoglycémie induite par la cibenzoline chez le sujet âgé.