Successful treatment of fulminant hepatitis B and fulminant hepatitis B and D coinfection explained by inhibitory effect on the immune response?
Foscarnet has been shown to inhibit the proliferation of human T and B lymphocytes in vitro. The production of lymphokines was more strongly affected than the DNA synthesis. Monocyte function was only partly inhibited by the highest foscarnet concentration tried. The influence of foscarnet on the immune system could explain the beneficial effect observed in patients with HBV-related fulminant hepatitis treated with foscarnet.
Hansson
B G
BG
Department of Medical Microbiology, University of Lund, Malmö General Hospital.
Riesbeck
K
K
Nordenfelt
E
E
Weiland
O
O
D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002460:Cell Line; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D017245:Foscarnet; D006509:Hepatitis B / Q000150:complications / Q000188:drug therapy; D003699:Hepatitis D / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000187:drug effects
D000998:Antiviral Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D017245:Foscarnet; D007371:Interferon-gamma; D004247:DNA; D010746:Phosphonoacetic Acid