A new approach to stabilize complementary complexes formed by short oligonucleotides and their derivatives.
A proposed approach to stabilize complementary complexes is based on the stabilizing effect of oligonucleotide derivatives bearing polyaromatic residues on the adjacent short oligonucleotides if their recognition sites make a tandem on the target. This approach has been used to enhance efficiency and specificity of site-specific modification of nucleic acids.
Zarytova
V F
VF
Institute of Bioorganic Chemistry, Siberian Division, Academy of Sciences of the USSR, Novosibirsk.
D001483:Base Sequence; D004355:Drug Stability; D007202:Indicators and Reagents; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D063065:Organophosphonates
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates