title: The role of glutathione in evaluating the efficacy of antimetabolites in transplanted tumors.
abstract: Levels of glutathione (GSH) in tumor cells play an important role in determining the clinical responses to certain anticancer agents. In the present work 5-fluorouracil and 5-fluorodeoxyuridine have been used as antineoplastic agents against transplanted Ehrlich ascites carcinoma. The glutathione levels in the tumor cells and liver tissues of the host animals have been studied by a specific histofluorescence method. Significant changes have been observed in the glutathione level of the host, tumor bearing and treated group of animals, the implications of which have been discussed.
authors.affiliation: Chittaranjan National Cancer Institute, Calcutta, India.
authors.forename: S
authors.initials: S
authors.lastname: Bose
authors.forename: S
authors.initials: S
authors.lastname: Guha
authors.forename: P
authors.initials: P
authors.lastname: Paul
authors.forename: M
authors.initials: M
authors.lastname: Chowdhury
authors.forename: S R
authors.initials: SR
authors.lastname: Chowdhury
authors.forename: U
authors.initials: U
authors.lastname: Sen
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D002452:Cell Count; D005260:Female; D005467:Floxuridine / Q000627:therapeutic use*; D005472:Fluorouracil / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008856:Microscopy, Fluorescence; D009368:Neoplasm Transplantation
chemical_list: D005467:Floxuridine; D005978:Glutathione; D005472:Fluorouracil