Cardiac content of brain natriuretic peptide in DOCA salt-hypertensive rats.
The cardiac content of immunoreactive rat brain natriuretic peptide (ir-rBNP) in deoxycorticosterone acetate (DOCA)-salt hypertensive rats was measured by radioimmunoassay (RIA). The atrial content of ir-rBNP was significantly lower in the DOCA-salt group than in the control group (p less than 0.01). However, the ventricular content of ir-rBNP was markedly increased in the DOCA-salt group as compared to the other groups. Ir-rBNP level in the atria was negatively correlated with other groups. Ir-rBNP level in the atria was negatively correlated with blood pressure (r = -0.49, p less than 0.01), while that in the ventricle was positively correlated with blood pressure (r = 0.79, p less than 0.001). A significant correlation was observed between tissue levels of ir-rBNP and ir-rat atrial natriuretic peptide (rANP) both in atrium and ventricle (atrium, r = 0.63, p less than 0.001; ventricle, r = 0.95, p less than 0.001). These results raise the possibility that rBNP as well as rANP functions as a cardiac hormone, the production of which probably changes in response to increased of body fluid and blood pressure.
Yokota
N
N
First Department of Internal Medicine Miyazaki Medical College, Japan.
Aburaya
M
M
Yamamoto
Y
Y
Kato
J
J
Kitamura
K
K
Kida
O
O
Eto
T
T
Minamino
N
N
Kangawa
K
K
Matsuo
H
H
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D001923:Brain Chemistry; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D009206:Myocardium / Q000737:chemistry*; D045283:Natriuretic Agents / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride
D045283:Natriuretic Agents; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D009320:Atrial Natriuretic Factor