title: A comparison of the myocardial metabolic and haemodynamic changes produced by propofol-sufentanil and enflurane-sufentanil anaesthesia for patients having coronary artery bypass graft surgery.
abstract: The purpose of this study was to compare propofol-sufentanil with enflurane-sufentanil anaesthesia for patients undergoing elective coronary artery bypass graft (CABG) surgery with respect to changes in (1) haemodynamic variables; (2) myocardial blood flow and metabolism; (3) serum cortisol, triglyceride, lipoprotein concentrations and liver function; and (4) recovery characteristics. Forty-seven patients with preserved ventricular function (ejection fraction greater than 40%, left ventricular end diastolic pressure less than or equal to 16 mmHg) were studied. Patients in Group A (n = 24) received sufentanil 0.2 microgram.kg-1 and propofol 1-2 mg.kg-1 for induction of anaesthesia which was maintained with a variable rate propofol (50-200 micrograms.kg-1.min-1) infusion and supplemental sufentanil (maximum total 5 micrograms.kg-1). Patients in Group B (n = 23) received sufentanil 5 micrograms.kg-1 for induction of anaesthesia which was maintained with enflurane and supplemental sufentanil (maximum total 7 micrograms.kg-1). Haemodynamic and myocardial metabolic profiles were determined at the awake-sedated, post-induction, post-intubation, first skin incision, post-sternotomy, and pre-cardiopulmonary bypass intervals. Induction of anaesthesia produced a larger reduction in systolic blood pressure in Group A (156 +/- 22 to 104 +/- 20 mmHg vs 152 +/- 26 to 124 +/- 24 mmHg; P less than 0.05). No statistical differences were detected at any other time or in any other variable including myocardial lactate production (n = 13 events in each group), time to tracheal extubation and time to discharge from the ICU. We concluded that, apart from hypotension on induction of anaesthesia, propofol-sufentanil anaesthesia produced anaesthetic conditions equivalent to enflurane-sufentanil anaesthesia for CABG surgery.
authors.affiliation: Department of Anaesthesia, Victoria General Hospital, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: R I
authors.initials: RI
authors.lastname: Hall
authors.forename: J T
authors.initials: JT
authors.lastname: Murphy
authors.forename: E A
authors.initials: EA
authors.lastname: Moffitt
authors.forename: R
authors.initials: R
authors.lastname: Landymore
authors.forename: P T
authors.initials: PT
authors.lastname: Pollak
authors.forename: L
authors.initials: L
authors.lastname: Poole
mesh_terms: D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000187:drug effects; D004737:Enflurane / Q000494:pharmacology*; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D015742:Propofol / Q000494:pharmacology*; D011446:Prospective Studies; D017409:Sufentanil; D014280:Triglycerides / Q000097:blood
chemical_list: D000777:Anesthetics; D008075:Lipoproteins, HDL; D014280:Triglycerides; D004737:Enflurane; D017409:Sufentanil; D005283:Fentanyl; D006854:Hydrocortisone; D015742:Propofol