title: Epidermodysplasia verruciformis-associated papillomavirus infection complicating human immunodeficiency virus disease.
abstract: Three males infected with the human immunodeficiency virus (HIV) were noted to have extensive flat warts of the face and/or body. In two there were also pityriasis versicolor-like lesions. Biopsies showed foamy, basophilic, distended cytoplasm in granular layer keratinocytes, characteristic of the human papillomavirus types seen in epidermodysplasia verruciformis. DNA hybridization techniques demonstrated the presence of HPV-type 8 in one patient and HPV 5 and 8 in another. Patients with immune suppression due to HIV infection may demonstrate the clinical features of epidermodysplasia verruciformis with the same potentially oncogenic HPV types.
authors.affiliation: Department of Dermatology, School of Medicine, University of California, San Francisco 94143-0506.
authors.forename: T G
authors.initials: TG
authors.lastname: Berger
authors.forename: W S
authors.initials: WS
authors.lastname: Sawchuk
authors.forename: C
authors.initials: C
authors.lastname: Leonardi
authors.forename: A
authors.initials: A
authors.lastname: Langenberg
authors.forename: J
authors.initials: J
authors.lastname: Tappero
authors.forename: P E
authors.initials: PE
authors.lastname: Leboit
mesh_terms: D000386:AIDS-Related Complex / Q000150:complications / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology; D000328:Adult; D015139:Blotting, Southern; D004279:DNA, Viral / Q000032:analysis; D004819:Epidermodysplasia Verruciformis / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D015658:HIV Infections / Q000150:complications*; D006679:HIV Seropositivity / Q000150:complications; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D012867:Skin / Q000473:pathology
chemical_list: D004279:DNA, Viral