title: [The distribution of various type of oncogenes products in the tumor tissue of malignant mesothelioma].
abstract: The distribution of various oncogenes in the tumor tissues of 8 cases of malignant mesothelioma related to asbestos exposure was evaluated by monoclonal antibodies against oncogenes. There was no staining for K-ras, H-ras and erb-B in all cases and C-abl slightly stained in only one case of a biphasic type of tumor. On the other hand, C-myc positively stained in epithelioid type and the epitheloidal portion of the biphasic type of tumors. C-neu, C-fos and N-myc positively stained in almost all cases. Of these 9 oncogenes, C-neu was most frequently stained in all cases. These results suggest that C-myc, N-myc, C-neu and C-fos oncogenes may have some role in the appearance of malignant mesothelioma related to asbestos exposure.
authors.affiliation: Department of Clinical Investigation Kure Kyosai Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D000368:Aged; D001194:Asbestos / Q000009:adverse effects*; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008654:Mesothelioma / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D015513:Oncogene Proteins / Q000378:metabolism*; D011519:Proto-Oncogenes
chemical_list: D015513:Oncogene Proteins; D001194:Asbestos