title: Hydrocortisone sensitivity. An investigation into the nature of the allergen.
abstract: 11 patients, positive to tixocortol pivalate on patch testing, were tested intradermally with a variety of hydrocortisone analogues. Substitution at the C21 position had no effect on the occurrence of positive reactions to hydrocortisone, whereas alteration of any of the carbon rings significantly reduced the number of positive reactions. We suggest that the C17 side chain is involved in protein binding and subsequent presentation of antigenic sites on the carbon rings.
authors.affiliation: Department of Dermatology, North Staffordshire Hospital Centre, Hartshill, Stoke-on-Trent, UK.
authors.forename: S M
authors.initials: SM
authors.lastname: Wilkinson
authors.forename: J S
authors.initials: JS
authors.lastname: English
mesh_terms: D000287:Administration, Topical; D000485:Allergens; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D003429:Cross Reactions / Q000276:immunology; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects* / Q000031:analogs & derivatives; D007271:Injections, Intradermal; D010328:Patch Tests
chemical_list: D000485:Allergens; D000893:Anti-Inflammatory Agents; C019112:tixocortol pivalate; D006854:Hydrocortisone