title: [Treatment of primary pulmonary hypertension with high doses of nifedipine controlled by Doppler echocardiography].
abstract: In a 22 year old female with primary pulmonary hypertension Doppler echocardiography revealed a systolic gradient between the right atrium and ventricle of 11.3 kPa (85 mmHg). A trial of high dose nifedipine therapy was started. It's efficacy was assessed by monitoring the tricuspid gradient. During therapy variations of the gradient were seen but without a favorable, steady, decrease trend. Although nifedipine did not produce any improvement during the "acute trial"--nifedipine therapy was continued--initially 60 mg, followed by 80 mg and finally 100 mg per day. Efficacy of this therapy was also controlled by Doppler echocardiography. Nifedipine was discontinued after 8 months due to lack of improvement in the patient's state. The patient died 30 months from the initial symptoms. Pathomorphological examination confirmed the clinical diagnosis. The use of Doppler echocardiography in assessing the vasodilators in primary pulmonary hypertension is discussed.
authors.affiliation: Kliniki Chorób Wewnetrznych Instytutu Gruzlicy i Chorób Płuc, Warszawie.
authors.forename: A
authors.initials: A
authors.lastname: Radomyski
authors.forename: T
authors.initials: T
authors.lastname: Pasierski
authors.forename: A
authors.initials: A
authors.lastname: Torbicki
authors.forename: W
authors.initials: W
authors.lastname: Tomkowski
authors.forename: S
authors.initials: S
authors.lastname: Filipecki
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D016903:Drug Monitoring; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D009543:Nifedipine / Q000008:administration & dosage*; D011651:Pulmonary Artery / Q000187:drug effects* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D009543:Nifedipine
vernacular_title: Próba leczenia pierwotnego nadciśnienia płucnego wysokimi dawkami nifedypiny pod kontrola echokardiografii dopplerowskiej.