title: Regulation of atrial natriuretic peptide release in normal humans.
abstract: Atrial volume, pressure, and heart rate are considered the most important modulators of atrial natriuretic peptide (ANP) release, although their relative role is unknown. Continuous positive-pressure breathing in normal humans may cause atrial pressure and atrial volume to go in opposite directions (increase and decrease, respectively). We utilized this maneuver to differentially manipulate atrial volume and atrial pressure and evaluate the effect on ANP release. Effective filling pressure (atrial pressure minus pericardial pressure) was also monitored, because this variable has been proposed as another modulator of ANP secretion. We measured right atrial (RA) pressure, RA area, esophageal pressure (reflection of pericardial pressure), and RA and peripheral venous ANP in seven healthy adult males at rest and during continuous positive-pressure breathing (19 mmHg for 15 min). Continuous positive-pressure breathing decreased RA area (mean +/- SE, *P less than 0.05) 13.6 +/- 1.1 to 10.5 +/- 0.8* cm2, increased RA pressure 4 +/- 1 to 16 +/- 1* mmHg, increased esophageal pressure 2 +/- 1 to 12 +/- 1* mmHg, and increased effective filling pressure 2 +/- 0 to 4 +/- 1* mmHg. RA ANP increased from 67 +/- 17 to 91 +/- 18* pmol/l and peripheral venous ANP from 43 +/- 4 to 58 +/- 6* pmol/l.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Veterans Affairs Medical Center, Indiana University Medical School, Indianapolis 46202.
authors.forename: E T
authors.initials: ET
authors.lastname: Mannix
authors.forename: M O
authors.initials: MO
authors.lastname: Farber
authors.forename: G R
authors.initials: GR
authors.lastname: Aronoff
authors.forename: E M
authors.initials: EM
authors.lastname: Cockerill
authors.forename: T
authors.initials: T
authors.lastname: Ryan
authors.forename: T Y
authors.initials: TY
authors.lastname: Sullivan
authors.forename: S
authors.initials: S
authors.lastname: Carlone
authors.forename: P
authors.initials: P
authors.lastname: Palange
authors.forename: P
authors.initials: P
authors.lastname: Galassetti
authors.forename: P
authors.initials: P
authors.lastname: Serra
mesh_terms: D000328:Adult; D016275:Atrial Function; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006334:Heart Function Tests; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D012016:Reference Values; D012129:Respiratory Function Tests
chemical_list: D009320:Atrial Natriuretic Factor