Similarity of age-dependent changes in renal and striatal dopamine receptors.
A comparative analysis of the age-dependent changes in renal DA-1 and striatal D-1 dopamine receptors was performed in 3-(young), 12-(adult) and 27-(aged) month-old male Wistar rats by means of combined radioreceptor binding and autoradiographic techniques. 3H-SCH 23390 was used as a ligand of DA-1 or D-1 receptors. Experiments were performed on frozen sections of the kidney and of the striatum. The affinity of the ligand for both renal or striatal receptors did not show age-dependent changes. A significant loss in the density of DA-1 and D-1 sites was observed in the adult in comparison with young rats. A further decrease in the density of these sites was noticeable between adult and aged animals. These results suggest that renal DA-1 and striatal D-1 receptors are sensitive to aging to the same extent.
Mancini
M
M
Department of Public Health and Cellular Biology, Tor Vergata University, Rome, Italy.
Ricci
A
A
Zaccheo
D
D
Amenta
F
F
D000375:Aging / Q000502:physiology*; D000818:Animals; D001345:Autoradiography; D001552:Benzazepines / Q000493:pharmacokinetics; D003342:Corpus Striatum / Q000033:anatomy & histology*; D007668:Kidney / Q000294:innervation*; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*; D017447:Receptors, Dopamine D1
D001552:Benzazepines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1