title: A newly discovered xenobiotic metabolic pathway: ethyl ester formation.
abstract: Formation of etretinate, ethyl ester of acitretin, can be confirmed in vitro and in vivo using acitretin as the substrate. Etretinate was identified by LC/MS. The in vitro incubation was performed using rat and human liver 12,000 g supernatant, and the in vivo experiment was conducted in rats after oral dosing of acitretin. The ethyl ester formation was greatly enhanced by addition of or dosing with ethanol.
authors.affiliation: Pharmaceutical Research, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
authors.forename: R C
authors.initials: RC
authors.lastname: Chou
authors.forename: R
authors.initials: R
authors.lastname: Wyss
authors.forename: C A
authors.initials: CA
authors.lastname: Huselton
authors.forename: U W
authors.initials: UW
authors.lastname: Wiegand
mesh_terms: D017255:Acitretin; D000818:Animals; D004951:Esterification / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D005050:Etretinate / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D051381:Rats; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D000431:Ethanol; D014212:Tretinoin; D005050:Etretinate; D017255:Acitretin