title: [Effects of diltiazem on hemodynamics, plasma catecholamine and renin activity during exercise in hypertension].
abstract: The effects of diltiazem on hemodynamics, plasma catecholamine and plasma renin activity were studied during treadmill exercise test in 9 cases with moderate essential hypertension. Diltiazem of 120 mg/day was orally administered for 4 weeks. At maximum exercise, significant decrease in systolic blood pressure (-32 mmHg), heart rate (-16/min), pressure-rate product (-7,883 mmHg/min), plasma norepinephrine (-195 ng/L) and plasma epinephrine (-11 ng/L) were observed; while, diastolic blood pressure, ST depression and plasma renin activity showed no significant change. Also, a significant correlation between systolic blood pressure and plasma norepinephrine (r = 0.57, p < 0.001), especially after diltiazem therapy (r = 0.68, p < 0.001), was observed. These findings indicated that diltiazem can reduce the secretion of catecholamine from the sympathetic nerves during exercise in patients with essential hypertension.
authors.affiliation: First Department of Internal Medicine, National Defense Medical College, Tokorozawa.
authors.forename: K
authors.initials: K
authors.lastname: Isojima
authors.forename: B
authors.initials: B
authors.lastname: Takase
authors.forename: K
authors.initials: K
authors.lastname: Arakawa
authors.forename: T
authors.initials: T
authors.lastname: Shibuya
authors.forename: K
authors.initials: K
authors.lastname: Satomura
authors.forename: K
authors.initials: K
authors.lastname: Mizuno
authors.forename: A
authors.initials: A
authors.lastname: Kurita
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D002395:Catecholamines / Q000097:blood*; D004110:Diltiazem / Q000494:pharmacology* / Q000627:therapeutic use; D004562:Electrocardiography; D015444:Exercise; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D008875:Middle Aged; D012083:Renin / Q000097:blood*
chemical_list: D002395:Catecholamines; D012083:Renin; D004110:Diltiazem