Dura covered with fibrin glue reduces adhesions in abdominal wall defects.
Dura can greatly facilitate the closure of abdominal wall defects. However, a main disadvantage of its use are the adhesions which develop between omentum, bowel and dura and may lead to bowel obstructions. In this study various groups of rats had either the anterior wall replaced by untreated dura or by dura covered with fibrin glue prior to implantation. Adhesions were found in 75% of sham operated rats, 100% after untreated dura implantation and 50% after the implantation of fibrin glue treated dura.
Schier
F
F
University Medical Center Steglitz Berlin, Germany.
Srour
N
N
Waldschmidt
J
J
D000009:Abdominal Muscles / Q000002:abnormalities* / Q000601:surgery; D000818:Animals; D003094:Collagen; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006554:Hernia, Umbilical / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000517:prevention & control
D015718:Fibrin Tissue Adhesive; C032281:Lyodura; D003094:Collagen