title: [Treatment of chronic hepatitis B with interferon alfa-2b (Intron A)].
abstract: Eighteen patients with biopsy proven chronic hepatitis B and markers of ongoing viral replication were treated with interferon alpha-2b (Intron A) while 24 similar patients served as control group. Permanent termination of HBV replication and normalization of ALT and AST activity was seen in 7 (39%) treated patients and in only two (8%) controls (p less than 0.05). Adverse reactions were few and subsided with the termination of therapy. These results of interferon therapy in chronic hepatitis B seem encouraging.
authors.affiliation: Klinika Hepatologii Zakaźnej Instytutu Chorób Zakaźnych i Pasozytniczych AM, Warszawie.
authors.forename: J
authors.initials: J
authors.lastname: Cianciara
authors.forename: T
authors.initials: T
authors.lastname: Laskus
authors.forename: H
authors.initials: H
authors.lastname: Hryniewicz
authors.forename: J
authors.initials: J
authors.lastname: Jabłońska
authors.forename: T
authors.initials: T
authors.lastname: Loch
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000628:therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012074:Remission Induction
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
vernacular_title: Leczenie przewlekłego zapalenia watroby typu B preparatem interferon alfa-2b (Intron A).