title: Sjögren's syndrome complicated by cryoglobulinaemia and acute renal failure.
abstract: A patient is described with Sjögren's syndrome and an IgM-kappa gammopathy. With time cryoglobulins, the cause of acute renal failure, could be detected. The kidney biopsy showed a proliferative glomerulonephritis as is frequently seen with mixed cryoglobulinaemia. Plasmapheresis and immunosuppression resulted in long-term improvement of kidney function. The differential diagnosis of acute renal failure of glomerular origin in a patient with Sjögren's syndrome is discussed. This case report illustrates once more the consequences of monoclonal B-cell lymphocyte activation in Sjögren's syndrome.
authors.affiliation: Division of General Internal Medicine, St. Radboud University Hospital, Nijmegen, The Netherlands.
authors.forename: M Y
authors.initials: MY
authors.lastname: van Eer
authors.forename: P M
authors.initials: PM
authors.lastname: Netten
authors.forename: G
authors.initials: G
authors.lastname: Schrijver
authors.forename: K J
authors.initials: KJ
authors.lastname: Assmann
authors.forename: H
authors.initials: H
authors.lastname: Wollersheim
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000368:Aged; D001706:Biopsy; D003449:Cryoglobulinemia / Q000150:complications*; D005260:Female; D006801:Humans; D012859:Sjogren's Syndrome / Q000150:complications*