[A study of histamine receptors in peripheral lymphocytes in asthmatic subjects].
The identification and quantitative analysis of specific histamine H1 and H2 receptors on lymphocytes were acquired and histamine-induced suppressor cell activity was examined by using 3H-histamine radioligand-binding assay and co-culture technique. The quantitative analysis of H2 receptors decreased on the lymphocytes of extrinsic asthmatic subjects. Peripheral-lymphocytes from asthmatic subjects generated less histamine-induced suppressor activity than did those from normal individuals. In the asthmatics, the functional suppressor-cell abnormality positively correlated with the decreased quantity of H2 receptors on the lymphocytes.
Shen
C
C
Chang Zheng Hospital, Second Military Medical University, PLA.
D000328:Adult; D001249:Asthma / Q000097:blood*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry*; D008297:Male; D011869:Radioligand Assay; D011969:Receptors, Histamine H1 / Q000032:analysis*; D011970:Receptors, Histamine H2 / Q000032:analysis*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2