[Effect of alpha-human atrial natriuretic factor on isolated myocardial contractile force and action potential duration in guinea pigs].
The effect of alpha-hANF on contractile force and action potential duration (APD) of isolated myocardium in guinea pig was investigated. At the level of 20 nmol/L and 40 nmol/L alpha-hANF, the contraction amplitude and rate of contraction phase decreased to a remarkable extent. And at 40 nmol/L, APDs were shortened significantly 20 min after alpha-hANF. The results suggest that there exists a direct inhibitory effect of alpha-hANF on myocardial contractile force and action potential duration.
Wu
W J
WJ
Section of Physiology, Zhoushan Health School, Zhejiang.
Xia
Q A
QA
D000200:Action Potentials; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D010210:Papillary Muscles / Q000502:physiology
C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor