[The effect of the interferon inducer ridostin on photrin-induced mutagenesis in bone marrow cells in mice].
The number of aberrant metaphases was used to assess the influence of a highly active interferon inducer--ridostin, a two-spiral RNA, on spontaneous mutagenesis and that induced by an antitumor drug photrin. A new property of ridostin, viz. the antimutagenic effect, was established. The effect may be important for protection of cells from potent mutagens such as cytotoxic drugs used for cancer treatment.
Zolotareva
G N
GN
Loginova
N S
NS
Parshina
O V
OV
Nosik
N N
NN
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001388:Aziridines / Q000494:pharmacology*; D003864:Depression, Chemical; D007369:Interferon Inducers / Q000494:pharmacology*; D008297:Male; D051379:Mice; D016296:Mutagenesis / Q000187:drug effects*; D012330:RNA, Double-Stranded / Q000494:pharmacology; D012331:RNA, Fungal
D000970:Antineoplastic Agents; D001388:Aziridines; D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; C076741:ridostin; C007779:fotrin
Vliianie induktora interferona ridostina na indutsirovannyĭ fotrinom mutagenez v kletkakh kostnogo mozga mysheĭ.