title: Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B beta.
abstract: Complementary DNA coding for a catalytic subunit of protein phosphatase 2B was isolated from a human teratocarcinoma library. It encodes a third isoform of protein phosphatase 2B beta, and differs from the cDNA for the second isoform by a deletion of 30 base pairs in the coding region. The deletion results in the loss of ten amino acids between the putative calmodulin site and a postulated autoinhibitory domain. An identical deletion occurs in one of the two alternatively spliced isoforms of PP2B alpha.
authors.affiliation: Department of Biochemistry, The University, Dundee, U.K.
authors.forename: A E
authors.initials: AE
authors.lastname: McPartlin
authors.forename: H M
authors.initials: HM
authors.lastname: Barker
authors.forename: P T
authors.initials: PT
authors.lastname: Cohen
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001921:Brain / Q000201:enzymology; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D004273:DNA, Neoplasm / Q000235:genetics*; D015723:Gene Library; D006801:Humans; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D012326:RNA Splicing; D012689:Sequence Homology, Nucleic Acid; D013724:Teratoma / Q000201:enzymology
chemical_list: D002148:Calmodulin-Binding Proteins; D004273:DNA, Neoplasm; D046911:Macromolecular Substances; D015345:Oligonucleotide Probes; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases