[Polypeptide growth factors and their interrelation with hormones in the blood plasma of patients with primary bone tumors].
A relationship between blood plasma levels of polypeptide growth factors and those of peptide and sex steroid hormones, as assayed radioimmunologically, was studied in 91 patients with bone tumors of various histology and 45 healthy donors. The levels of insulin-like growth factor (IGF-1) and somatotropic hormone were significantly higher in cases of chondrosarcoma and patients suffering osteogenic sarcoma in the late puberal period as compared to controls and cases of fibrous histiocytoma, giant-cell tumor, benign tumors and tumor-like lesions of the bone. The peak levels of IGF-1, somatotropic hormone and insulin were registered in osteogenic sarcoma patients who developed pulmonary metastases either in the course or after the completion of combined treatment. Somatostatin level was significantly lower in patients with osteogenic sarcoma aged 11-20 years as compared to healthy adolescents, the lowest level being observed in adolescents suffering osteogenic sarcoma with metastases to the lungs. No relationship was established between total testosterone level, on the one hand, and those of IGF-1 and epidermal growth factor, on the other. A reverse correlation was established between concentrations of IGF-1 and total estradiol. The role of polypeptide growth factor antagonists in combined treatment of bone sarcomas is discussed.
Kushlinskiĭ
N E
NE
Bassalyk
L S
LS
Kuz'mina
Z V
ZV
Solov'ev
Iu N
IuN
Eremina
L A
LA
Amiraslanov
A T
AT
Shatskaia
V A
VA
Demina
D G
DG
Fedenko
A N
AN
Siniukov
P A
PA
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000097:blood* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006133:Growth Substances / Q000097:blood*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000556:secondary; D008297:Male; D010455:Peptides / Q000097:blood*; D012509:Sarcoma / Q000097:blood* / Q000628:therapy
D006133:Growth Substances; D006728:Hormones; D010455:Peptides
Polipeptidnye faktory rosta i ikh vzaimosviaz' s gormonami v plazme krovi bol'nykh s pervichnymi opukholiami kosteĭ.