[Changes in lipid metabolism in the myocardium as one of the possible mechanisms of the development of the overload form of heart failure].
In addition to hypertrophy of the myocardium, there are changes in its lipid composition as evidenced by activated lipid peroxidation, lower quantities of unsaturated fatty acids, and higher amounts of saturated phospholipids and lysophospholipids in overload heart failure induced by aortic coarctation. The derangement of the lipid environment may contribute to a decrease in the powerful capacity of membraneous enzyme systems, disturbances in ion transport and cardiac diastolic relaxation, which is one of the causes of heart failure.
Khanina
N Ia
NIa
D000818:Animals; D002303:Cardiac Output, Low / Q000209:etiology*; D006332:Cardiomegaly / Q000150:complications; D004195:Disease Models, Animal; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008246:Lysophospholipids / Q000172:deficiency; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
D005231:Fatty Acids, Unsaturated; D008246:Lysophospholipids
Izmenenie obmena lipidov v miokarde kak odin iz vozmozhnykh mekhanizmov razvitiia peregruzochnoĭ formy serdechnoĭ nedostatochnosti.