title: The gene for human neurone specific ubiquitin C-terminal hydrolase (UCHL1, PGP9.5) maps to chromosome 4p14.
abstract: Ubiquitin carboxy terminal hydrolase 1, UCHL1, is a neurone-specific protein involved in the ubiquitin-mediated proteolytic pathway. The gene for human UCHL1 has been mapped to chromosome 4 using the polymerase chain reaction to amplify specifically the human UCHL1 sequences in rodent/human somatic cell hybrid DNA. A regional assignment of this locus to 4p14 has been made by in situ hybridization to metaphase chromosomes using both tritium and fluorescently labelled probes.
authors.affiliation: M.R.C. Human Biochemical Genetics Unit, Galton Laboratory, London.
authors.forename: Y H
authors.initials: YH
authors.lastname: Edwards
authors.forename: M F
authors.initials: MF
authors.lastname: Fox
authors.forename: S
authors.initials: S
authors.lastname: Povey
authors.forename: L J
authors.initials: LJ
authors.lastname: Hinks
authors.forename: R J
authors.initials: RJ
authors.lastname: Thompson
authors.forename: I N
authors.initials: IN
authors.lastname: Day
mesh_terms: D001483:Base Sequence; D002871:Chromosome Banding; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D013869:Thiolester Hydrolases / Q000235:genetics*; D043222:Ubiquitin Thiolesterase
chemical_list: D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase