Synthesis and anti-HIV activity of carbovir and related carbocyclic nucleosides.
(+/-) Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir) is an antiretroviral agent which is undergoing preclinical evaluation for the treatment of AIDS. Its hydrolytic stability and its ability to inhibit infectivity and replication of HIV in T-cells at concentrations of approximately 400-fold below toxic concentrations make Carbovir an excellent candidate for development as a potential antiretroviral agent.
Vince
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Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455-0343.
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D009705:Nucleosides; C057503:carbovir