[Improved control of cisplatin-induced emesis with high-dose metoclopramide, dexamethasone and lorazepam].
Despite treatment, emesis remains a major problem with cisplatin chemotherapy. Three potent antiemetics, metoclopramide, dexamethasone and lorazepam, were combined in prophylaxis of 18 patients receiving cisplatin based combination chemotherapy. In 75 courses of chemotherapy, 57% experienced complete protection from vomiting and 89% of treatment courses had two or fewer vomiting episodes. Complete protection and mild episodes from nausea was 47% and 53% respectively. Toxicities were mild and infrequent. It was concluded that combination of high-dose metoclopramide, dexamethasone and lorazepam was highly efficacious in preventing nausea and vomiting in moderate or high-dose cisplatin chemotherapy with little side effects.
Mau
Y K
YK
Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital.
Li
Y T
YT
Tsui
M S
MS
Tu
F C
FC
Hsu
K P
KP
D002945:Cisplatin / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage* / Q000009:adverse effects; D008787:Metoclopramide / Q000008:administration & dosage* / Q000009:adverse effects; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
D003907:Dexamethasone; D008787:Metoclopramide; D008140:Lorazepam; D002945:Cisplatin