The effect of alloxan-induced diabetes on triamine lesions in the ventromedial hypothalamus.
It has been demonstrated that the ventromedial hypothalamus (VMH) of alloxan-induced diabetic mice is protected from subsequent gold thioglucose (GTG)-induced lesions. Another compound, 3,3'-methyliminobis-(N-methylpropylamine) (MIMPA), a triamine structurally unrelated to GTG, has been shown to cause similar VMH lesions in mice. We chose to investigate the effect of alloxan-induced diabetes on VMH lesion formation in MIMPA-treated mice. In this study CF-1 female mice were made diabetic by a simple intravenous (IV) injection of alloxan and subsequently treated with MIMPA by subcutaneous injection (SC). Contrary to studies which showed that GTG-induced VMH lesions are insulin dependent, an insulin deficiency did not inhibit MIMPA-induced lesions in the VMH of mice. Our data suggests, albeit GTG is suspected to induce VMH necrosis by attaching to glucoreceptors and insulin-sensitive neurons, MIMPA works by a different and as yet unknown mechanism. We conclude that MIMPA-induced lesions in the VMH of mice are not insulin dependent.
Brown
D F
DF
Department of Anatomy, University of Health Sciences, Kansas City, MO 64124.
McGuirk
J P
JP
Larsen
S P
SP
Minter
S D
SD
D000818:Animals; D001931:Brain Mapping; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005260:Female; D007328:Insulin / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D009498:Neurotoxins; D011073:Polyamines / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000503:physiopathology*
D007328:Insulin; D009498:Neurotoxins; D011073:Polyamines; D011956:Receptors, Cell Surface; C027786:glucose receptor; C033506:3,3'-methyliminobis(N-methylpropylamine)