title: [Clinical course and necrotic area size in patients with myocardial infarct receiving combined treatment including antioxidants and membrane-protecting agents].
abstract: The efficacy of a combination of an antioxidant (alpha-tocopherol) and membrane-protective agents (nicotinamide, a lipase inhibitor and delagil, a phospholipase inhibitor) was evaluated in 25 patients with myocardial infarction in the acute period. The drugs were given no later than 8 hours of the onset of the disease within the first 10 days. Along with necrotic area limitation (by 20.2%) and neurotic myocardium was mass decrease by (34.9%), alpha-tocopherol in combination with nicotinamide and delagil was found to lower the frequency and severity of fatal complications, but fail to affect the incidence of relapses of postinfarction angina.
authors.forename: A A
authors.initials: AA
authors.lastname: Dzizinskiĭ
authors.forename: V P
authors.initials: VP
authors.lastname: Katiubin
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002738:Chloroquine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D009536:Niacinamide / Q000008:administration & dosage*; D013997:Time Factors; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014810:Vitamin E; D009536:Niacinamide; C023676:chloroquine diphosphate; D002738:Chloroquine
vernacular_title: Klinicheskoe techenie i velichina zony nekroza u bol'nykh infarktom miokarda pod vliianiem kompleksnogo lecheniia s vkliucheniem antioksidantov i membranoprotektorov.