[Inhibitor effect of CD8+CD57+ lymphocytes on cell-mediated cytotoxicity: characterization of suppressor factor].
We report a new suppressor function of CD8+CD57+ lymphocytes from HIV-seropositive patients or allotransplanted recipients, on the cytolytic activity of allospecific CTL, NK and LAK cells. This inhibitory effect is mediated by a non-antigen specific soluble factor distinct from PGE2, TGF beta and TNF alpha beta. A preliminary biochemical characterization indicates that the CD8+CD57+ inhibitory activity 1. is heat and trypsin resistant, 2. specifically binds to Concanavalin A suggesting its glycosylation, 3. is mediated by a 20-30 kD molecule.
Autran
B
B
Laboratoire d'Immunologie cellulaire et tissulaire, U.A.-C.N.R.S. n. 186, Paris.
Sadat-Sowti
B
B
Debre
P
P
D016026:Bone Marrow Transplantation / Q000276:immunology; D015331:Cohort Studies; D006679:HIV Seropositivity / Q000276:immunology; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000187:drug effects / Q000276:immunology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D013491:Suppressor Factors, Immunologic / Q000494:pharmacology*; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000737:chemistry
D013491:Suppressor Factors, Immunologic
Effet inhibiteur des lymphocytes CD8+CD57+ sur la cytotoxicité à médiation cellulaire: caractérisation d'un facteur suppresseur.