[Pharmacokinetics of cyclosporin A in renal transplant patients after infusion].
Seventeen patients after renal transplantation were infused iv cyclosporin A (CsA) 0.65 +/- 0.13 mg.kg-1.h-1. Blood CsA was determined by fluorescence polarization immunoassay (FPIA). Pharmacokinetic parameters were calculated from micro-computer pharmacokinetic programme T1/2 beta = 8.6 +/- 3.4 h, Vd = 3.2 +/- 1.3 L.kg-1. No significant difference was found between sexes and between age groups.
Gu
C N
CN
Department of Clinical Pharmacology, Changzheng Hospital, Shanghai, China.
Deng
Y L
YL
Zhu
Y H
YH
Zhu
C J
CJ
Gu
Q P
QP
D000328:Adult; D016572:Cyclosporine / Q000493:pharmacokinetics*; D005260:Female; D016231:Fluorescence Polarization Immunoassay; D006801:Humans; D007262:Infusions, Intravenous; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
D016572:Cyclosporine