Differences in the induction of tumorspecific T suppressor lymphocytes among the peritoneal exudate cells in histocompatible BALB/cAnPt and BALB/cJ mouse sublines.
The BALB/c inbred strain of mice exists in several sublines, two of which are of special interest to tumorimmunologists. BALB/cAnPt mice develop plasmacytomas upon intraperitoneal injection of mineral oil in 61% of the animals. BALB/cJ mice on the other hand are relatively resistant and only a few animals develop tumors. The cellular immune response of BALB/cAnPt mice towards the transplantable plasmacytoma ADJ-PC-5 is characterized by the dominance of specific T suppressor (Ts) lymphocytes, when an immunization protocol is used which mimics some aspects of early stages of tumorigenesis by increasing exponentially the antigenic tumor load. Application of this in vivo induction protocol for Ts cells reveals that ADJ-PC-5-specific Ts cells capable of suppressing the generation of an in vitro cytotoxic response can be induced in BALB/cAnPt but not in BALB/cJ mice. No subline difference could be found when specific Ts cells were induced in vitro. The data point towards a subline difference of in vivo cell interactions rather than T cell repertoire composition.
Lügering
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N
Institut für Immunologie, Universität Münster, Germany.
Kölsch
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E
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D006648:Histocompatibility / Q000276:immunology*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D010954:Plasmacytoma / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*