title: Assignment of beta-hexosaminidase A alpha-subunit to human chromosomal region 15q23----q24.
abstract: Tay-Sachs disease results from a mutation in the alpha subunit of beta-hexosaminidase. Using a cDNA clone, we have mapped the gene to 15q23----q24 by in situ hybridization.
authors.affiliation: Department of Human Genetics, Rosewell Park Memorial Institute, Buffalo, NY 14263.
authors.forename: H
authors.initials: H
authors.lastname: Nakai
authors.forename: M G
authors.initials: MG
authors.lastname: Byers
authors.forename: N J
authors.initials: NJ
authors.lastname: Nowak
authors.forename: T B
authors.initials: TB
authors.lastname: Shows
mesh_terms: D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15 / Q000648:ultrastructure*; D015342:DNA Probes; D005796:Genes; D006801:Humans; D009693:Nucleic Acid Hybridization; D013661:Tay-Sachs Disease / Q000235:genetics*; D001619:beta-N-Acetylhexosaminidases / Q000235:genetics*
chemical_list: D015342:DNA Probes; D001619:beta-N-Acetylhexosaminidases