title: Increase in D2 dopamine receptors in the substantia nigra after chronic (-)-sulpiride treatment.
abstract: Changes in D2 dopamine (DA) receptors in the substantia nigra (SN) and caudate nucleus (CN) homogenates were studied in rats following chronic treatment with the specific D2 receptor antagonist (-)-sulpiride (50 mg/kg s.c. twice daily for 8 days). Sixty hours after (-)-sulpiride withdrawal, the Bmax of [3H]spiroperidol binding (in the presence of 30 Nm ketanserin) was found to be increased by 76% and 38% in the SN and CN, respectively. No changes in the KdS were observed. The findings suggest that chronic (-)-sulpiride results in the upregulation of DA autoreceptors in the SN.
authors.affiliation: B.B. Brodie Department of Neuroscience, University of Cagliari, Medical School, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Stefanini
authors.forename: M
authors.initials: M
authors.lastname: Frau
authors.forename: G L
authors.initials: GL
authors.lastname: Gessa
mesh_terms: D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D013134:Spiperone / Q000493:pharmacokinetics / Q000494:pharmacology; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism*; D013469:Sulpiride / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D013134:Spiperone; D013469:Sulpiride; D007650:Ketanserin