title: Clonal analysis of transient myeloproliferative disorder in Down's syndrome.
abstract: Three Down's syndrome patients with transient myeloproliferative disorder were studied for clonality of the proliferating blast cells using the X chromosome-linked polymorphic gene phosphoglycerate kinase, immunoglobulin heavy chain (IgH) gene and T-cell antigen receptor (TCR) (beta, gamma, delta) genes. None of the three cases showed rearrangements of IgH, TCR beta, gamma, or delta genes, indicating the non-lymphoid nature of the proliferating blast cells. The X chromosome inactivation pattern showed that the cells in the blast population in all of the three cases of transient myeloproliferative disorder were clonal. These data suggest that at least some of this disorder can be due to a spontaneously regressing clone of malignant cells.
authors.affiliation: Department of Virology, National Children's Medical Research Center, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyashita
authors.forename: M
authors.initials: M
authors.lastname: Asada
authors.forename: J
authors.initials: J
authors.lastname: Fujimoto
authors.forename: T
authors.initials: T
authors.lastname: Inaba
authors.forename: Y
authors.initials: Y
authors.lastname: Takihara
authors.forename: K
authors.initials: K
authors.lastname: Sugita
authors.forename: F
authors.initials: F
authors.lastname: Bessho
authors.forename: T
authors.initials: T
authors.lastname: Furukawa
authors.forename: S
authors.initials: S
authors.lastname: Mizutani
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood* / Q000235:genetics / Q000276:immunology; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D009196:Myeloproliferative Disorders / Q000209:etiology / Q000276:immunology*; D010735:Phosphoglycerate Kinase / Q000235:genetics; D014960:X Chromosome
chemical_list: D015703:Antigens, CD; D010735:Phosphoglycerate Kinase