[Effects of diltiazem on hemodynamics, plasma catecholamine and renin activity during exercise in hypertension].
The effects of diltiazem on hemodynamics, plasma catecholamine and plasma renin activity were studied during treadmill exercise test in 9 cases with moderate essential hypertension. Diltiazem of 120 mg/day was orally administered for 4 weeks. At maximum exercise, significant decrease in systolic blood pressure (-32 mmHg), heart rate (-16/min), pressure-rate product (-7,883 mmHg/min), plasma norepinephrine (-195 ng/L) and plasma epinephrine (-11 ng/L) were observed; while, diastolic blood pressure, ST depression and plasma renin activity showed no significant change. Also, a significant correlation between systolic blood pressure and plasma norepinephrine (r = 0.57, p < 0.001), especially after diltiazem therapy (r = 0.68, p < 0.001), was observed. These findings indicated that diltiazem can reduce the secretion of catecholamine from the sympathetic nerves during exercise in patients with essential hypertension.
Isojima
K
K
First Department of Internal Medicine, National Defense Medical College, Tokorozawa.
Takase
B
B
Arakawa
K
K
Shibuya
T
T
Satomura
K
K
Mizuno
K
K
Kurita
A
A
Nakamura
H
H
D000328:Adult; D000368:Aged; D002395:Catecholamines / Q000097:blood*; D004110:Diltiazem / Q000494:pharmacology* / Q000627:therapeutic use; D004562:Electrocardiography; D015444:Exercise; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D008875:Middle Aged; D012083:Renin / Q000097:blood*
D002395:Catecholamines; D012083:Renin; D004110:Diltiazem