title: Isolation of Bacillus stearothermophilus constituent that suppresses mouse mixed leukocyte reaction in vitro.
abstract: A novel immunosuppressant, Fr.5-B, has been isolated from the debris of Bacillus stearothermophilus UK563 autolysate. Fr.5-B suppressed mouse mixed leukocyte reaction at doses ranging from 10(-4) to 1 microgram/ml, but not proliferation stimulated by concanavalin A and lipopolysaccharide.
authors.affiliation: Faculty of Pharmaceutical Sciences, Osaka University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kohama
authors.forename: N
authors.initials: N
authors.lastname: Murayama
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Inada
authors.forename: T
authors.initials: T
authors.lastname: Nakanishi
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: X
authors.initials: X
authors.lastname: Ying
authors.forename: T
authors.initials: T
authors.lastname: Mimura
mesh_terms: D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D001411:Geobacillus stearothermophilus / Q000737:chemistry*; D007166:Immunosuppressive Agents / Q000302:isolation & purification*; D008070:Lipopolysaccharides / Q000302:isolation & purification; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D003208:Concanavalin A