title: Pharmacological evidence for histamine H3 receptor in the control of gastric acid secretion in cats.
abstract: We investigated the possible involvement of H3 receptor in the control of gastric acid secretion in the conscious cat provided with a gastric fistula [main stomach (MS)] and a denervated Heidenhain pouch (HP). Intravenous infusion of the selective H3 agonist (R)-alpha-methylhistamine at 3, 10, and 30 nmol.kg-1.h-1 induced a dose-related inhibition of pentagastrin-stimulated gastric acid output. Maximal inhibition in MS (48 +/- 3%, P less than 0.01) and HP (36 +/- 5%, P less than 0.01) was obtained with 30 nmol.kg-1.h-1. This dose also significantly inhibited peptone meal-induced gastric acid output by 38 +/- 4 and 46 +/- 8% (P less than 0.01) in MS and HP, respectively. These inhibitions were completely prevented by 10 nmol.kg-1.h-1 iv of the selective H3 receptor antagonist thioperamide. On the other hand, (R)-alpha-methylhistamine was without any effect on histamine-stimulated gastric acid output, whereas thioperamide produced a slight but not significant increase of this output in contrast to the H2 receptor antagonist ranitidine, which showed a strong inhibitory effect. These findings suggest that pentagastrin- or meal-induced gastric acid secretion involves an H3 receptor pharmacologically distinct from the H2 receptor.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Unité 10, Hôpital Bichat, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Bado
authors.forename: F
authors.initials: F
authors.lastname: Hervatin
authors.forename: M J
authors.initials: MJ
authors.lastname: Lewin
mesh_terms: D000818:Animals; D002415:Cats; D004044:Dietary Proteins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology*; D007700:Kinetics; D008761:Methylhistamines / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D011968:Receptors, Histamine / Q000187:drug effects / Q000502:physiology*; D018100:Receptors, Histamine H3
chemical_list: D004044:Dietary Proteins; D008761:Methylhistamines; D010880:Piperidines; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; D006632:Histamine; D010418:Pentagastrin; C052075:thioperamide; C048140:N-methylhistamine