title: Identification of a consistent pattern of mutations in neurovirulent variants derived from the sabin vaccine strain of poliovirus type 2.
abstract: Complete nucleotide sequencing of the RNAs of two unrelated neurovirulent isolates of Sabin-related poliovirus type 2 revealed that two nucleotides and one amino acid (amino acid 143 in the major capsid protein VP1) consistently departed from the sequences of the nonneurovirulent poliovirus type 2 712 and Sabin vaccine strains. This pattern of mutation appeared to be a feature common to all neurovirulent variants of poliovirus type 2.
authors.affiliation: Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Equestre
authors.forename: D
authors.initials: D
authors.lastname: Genovese
authors.forename: F
authors.initials: F
authors.lastname: Cavalieri
authors.forename: L
authors.initials: L
authors.lastname: Fiore
authors.forename: R
authors.initials: R
authors.lastname: Santoro
authors.forename: R
authors.initials: R
authors.lastname: Perez Bercoff
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D004252:DNA Mutational Analysis; D004279:DNA, Viral; D008969:Molecular Sequence Data; D009154:Mutation; D017955:Poliovirus / Q000235:genetics / Q000472:pathogenicity*; D011055:Poliovirus Vaccine, Oral / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D013122:Spinal Diseases / Q000382:microbiology; D014774:Virulence / Q000235:genetics
chemical_list: D036022:Capsid Proteins; D004279:DNA, Viral; D011055:Poliovirus Vaccine, Oral; C442540:VP1 protein, Poliovirus