title: The effects of subconjunctival mitomycin-C on glaucoma filtration surgery in rabbits.
abstract: A prospective, randomized, masked, placebo-controlled study was performed to determine whether a single, intraoperative subconjunctival application of a 0.5-mg/mL solution of mitomycin-C enhances the success of full-thickness filtration surgery in rabbits. Compared with control eyes, mitomycin-C-treated eyes showed significant increases in bleb duration from 8.1 +/- 2.4 to 68.0 +/- 20.8 days and in intraocular pressure reduction from 6.0 +/- 3.0 to 63.6 +/- 21.5 days. Histopathologic evaluation confirmed the inhibitory effects of mitomycin-C on fibrovascular, fibrocellular, and collagenous organization of the filtering blebs that resulted in their preservation. Transient, superficial, corneal vascularization anterior to the bleb occurred in all mitomycin-C-treated eyes. No other clinical or pathologic signs of undesirable side effects were noted. We studied the effectiveness and safety of a single intraoperative application of mitomycin-C in prolonging the success of filtration surgery in rabbits and its potential for similar use in humans.
authors.affiliation: Department of Ophthalmology, W. K. Kellogg Eye Center, Ann Arbor, MI 48105-1994.
authors.forename: T J
authors.initials: TJ
authors.lastname: Bergstrom
authors.forename: W S
authors.initials: WS
authors.lastname: Wilkinson
authors.forename: G L
authors.initials: GL
authors.lastname: Skuta
authors.forename: R L
authors.initials: RL
authors.lastname: Watnick
authors.forename: V M
authors.initials: VM
authors.lastname: Elner
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002921:Cicatrix / Q000517:prevention & control; D003131:Combined Modality Therapy; D005901:Glaucoma / Q000473:pathology / Q000601:surgery*; D007429:Intraocular Pressure / Q000187:drug effects; D007432:Intraoperative Period; D016685:Mitomycin / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D011817:Rabbits; D011897:Random Allocation
chemical_list: D016685:Mitomycin