The specificity of the disease induced by defective murine retroviruses containing abl, fos, or Ha-ras is usually not determined by their LTR.
The long terminal repeats (LTR) of the defective murine sarcoma viruses (MSV) containing v-abl, v-Ha-ras, or v-fos were exchanged for LTRs from other retroviruses having different tissue tropism. The new chimeric MSV were found to induce the same diseases as the parental viruses, indicating that sequences outside the LTR, most likely those of the oncogene, are responsible for the disease specificity of these defective MSV.
Jolicoeur
P
P
Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Québec, Canada.
Rassart
E
E
Massé
G
G
Paquette
Y
Y
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002678:Chimera; D003673:Defective Viruses / Q000235:genetics* / Q000472:pathogenicity; D005814:Genes, Viral; D016313:Genes, abl; D011905:Genes, ras; D051379:Mice; D008815:Mice, Inbred Strains; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos; D011519:Proto-Oncogenes; D012091:Repetitive Sequences, Nucleic Acid; D009053:Sarcoma Viruses, Murine / Q000235:genetics* / Q000472:pathogenicity; D012513:Sarcoma, Experimental / Q000382:microbiology*
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D011505:Protein-Tyrosine Kinases