Dominant expression of the T cell receptor BALB invariant delta (BID) chain in resident pulmonary lymphocytes is due to selection.
During ontogeny, the T cell receptor BALB invariant delta (BID) chain (Sim, G. -K. and Augustin, A., Cell 1990. 61:397) is generated in C57BL/6 fetal thymocytes at levels similar to those detected in BALB/c mice. Hence, the dominance of BID observed among resident pulmonary lymphocytes of BALB/c and of (BALB/c x C57BL/6) F1 and its absence in C57BL/6 mice is due to positive selection and peripheral expansion rather than to the inability of C57BL/6 mice to generate this particular rearrangement.
Sim
G K
GK
Basel Institute for Immunology, Switzerland.
Augustin
A
A
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D015329:Gene Rearrangement, T-Lymphocyte; D005799:Genes, Dominant; D008168:Lung / Q000276:immunology*; D008214:Lymphocytes / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000235:genetics / Q000276:immunology; D008969:Molecular Sequence Data; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D016692:Receptors, Antigen, T-Cell, gamma-delta
D011948:Receptors, Antigen, T-Cell; D016692:Receptors, Antigen, T-Cell, gamma-delta; D004247:DNA