Early anti-HBs antibody response to accelerated and to conventional hepatitis B vaccination regimens in healthy persons.
A significantly higher prevalence of a protective concentration of anti-HBs was achieved at 1 and 2 months among 132 healthy medical students who received an accelerated vaccination schedule with a recombinant hepatitis B vaccine (Engerix-B) than among 120 medical students who received a conventional regimen. With the accelerated schedule, however, 60% students at 1 month and 27% at 2 months were still unprotected (anti-HBs titre less than 10.0 IU/l). Additional passive immunisation should therefore continue to be offered if the accelerated schedule is adopted for post-exposure prophylaxis.
Harries
A D
AD
Regional Infectious Disease Unit, Fazakerley Hospital, Liverpool, U.K.
Clark
M
M
Beeching
N J
NJ
Lavelle
J
J
Mutton
K J
KJ
D000328:Adult; D000428:Alcohol Drinking; D003276:Contraceptives, Oral; D005260:Female; D006508:Hepatitis Antibodies / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology* / Q000517:prevention & control; D017325:Hepatitis B Vaccines; D006801:Humans; D008297:Male; D012907:Smoking; D014611:Vaccination; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage* / Q000276:immunology
D003276:Contraceptives, Oral; D006508:Hepatitis Antibodies; D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines