title: Synthesis and radiation dosimetry of 4-borono-2-[18F]fluoro-D,L-phenylalanine: a target compound for PET and boron neutron capture therapy.
abstract: The 18F-labeling of 4-borono-D-L-phenylalanine (BPA), a potential target compound for cancer treatment with boron neutron capture therapy, is described. By direct fluorination of BPA with [18F]AcOF or [18F]F2 followed by HPLC separation, 4-borono-2-[18F]fluoro-D,L-phenylalanine was prepared with radiochemical yields of 25-35% and with a radiochemical purity of over 99%. The tissue distribution study showed that the compound has potential as a tracer for pancreas imaging with positron emission tomography. Radiation dosimetry is also described.
authors.affiliation: Division of Radiopharmaceutical Chemistry, Tohoku University, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ishiwata
authors.forename: T
authors.initials: T
authors.lastname: Ido
authors.forename: A A
authors.initials: AA
authors.lastname: Mejia
authors.forename: M
authors.initials: M
authors.lastname: Ichihashi
authors.forename: Y
authors.initials: Y
authors.lastname: Mishima
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005462:Fluorine Radioisotopes; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D051379:Mice; D009502:Neutrons; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011874:Radiometry; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
chemical_list: D001896:Boron Compounds; D005462:Fluorine Radioisotopes; D011838:Radiation-Sensitizing Agents; D010649:Phenylalanine; C033685:4-boronophenylalanine