title: [Absorption of short-acting insulin mixed with different slow-release formulations].
abstract: Several authors point to a different action of soluble insulin when mixed with a lente formulation containing either protamine or zinc. We evaluated glucose and insulin profiles in 17 type I diabetics, every one of whom was given what was considered the optimal amount of insulin twenty minutes before a standard evening meal. The patients were studied on two occasions, one week apart. According to a randomized sequence, those who received first the protamine-soluble mixture, took the Zn-soluble combination after one week and vice-versa. At the same time, we determined anti-insulin antibodies in order to rule out any different immunological interference, in the two moments of the study. Our results confirm that protamine-insulin given together with regular shows a serum insulin peak which is earlier and higher than that obtained with the corresponding mixture of Zn-insulin and regular (ANOVA: F = 5, 96; p = 0.02); blood glucose levels were lower with the former regimen, even though the difference did not reach statistical significance. Our conclusion is that Zn-containing insulin partly inactivates regular insulin when administered in the same syringe, and this may have an impact on the long-term treatment of the diabetic patient.
authors.affiliation: Divisione di Medicina, Ospedale Civile di Vigevano.
authors.forename: D
authors.initials: D
authors.lastname: Gronda
authors.forename: L
authors.initials: L
authors.lastname: Cacciabue
authors.forename: C
authors.initials: C
authors.lastname: Mezzogori
authors.forename: M
authors.initials: M
authors.lastname: Rossin
authors.forename: E
authors.initials: E
authors.lastname: Ronchi
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D003692:Delayed-Action Preparations; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D049528:Insulin, Long-Acting / Q000008:administration & dosage / Q000493:pharmacokinetics*; D061389:Insulin, Regular, Pork; D008297:Male; D008875:Middle Aged; D011479:Protamines / Q000008:administration & dosage; D013997:Time Factors; D015032:Zinc / Q000008:administration & dosage
chemical_list: D001786:Blood Glucose; D003692:Delayed-Action Preparations; D007328:Insulin; D049528:Insulin, Long-Acting; D061389:Insulin, Regular, Pork; D011479:Protamines; C000006:insulin, neutral; D015032:Zinc
vernacular_title: Assorbimento dell'insulina pronta miscelata con diverse formulazioni ritardo.