Mechanism of renal vasoconstriction with thromboxane mimetic: engagement of tubuloglomerular feedback.
U-46,619 infused at 10 ng.kg-1.min-1 in anesthetized rats reduced the glomerular capillary pressure only during engagement of tubuloglomerular feedback (TGF). 100 ng.kg-1.min-1 induced renal vasoconstriction, whereas femoral vasoconstriction and a rise in BP required 1,000-10,000 ng.kg-1.min-1. These results implicate TGF in the extreme sensitivity of the kidney to TxA2/PG endoperoxide receptor activation.
Welch
W J
WJ
DVA Medical Center, Gainesville, Florida.
Wilcox
C S
CS
Folger
W H
WH
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000818:Animals; D005246:Feedback / Q000187:drug effects; D007678:Kidney Glomerulus / Q000187:drug effects*; D007684:Kidney Tubules / Q000187:drug effects*; D008297:Male; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011982:Receptors, Prostaglandin / Q000187:drug effects; D017482:Receptors, Thromboxane; D013931:Thromboxanes / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D011450:Prostaglandin Endoperoxides, Synthetic; D011982:Receptors, Prostaglandin; D017482:Receptors, Thromboxane; D013931:Thromboxanes; D014662:Vasoconstrictor Agents; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid