title: [Enhanced myocardial depression from bupivacaine in diabetic rats].
abstract: We examined the direct effects of bupivacaine on the diabetic rat myocardium using an isolated perfused (Langendorff) heart preparation. Rats were made diabetic by injection of streptozotocin (55 mg.kg-1, i. v.). 12 weeks after the administration of streptozotocin, hearts were excised and perfused using Langendorff technique. Following 60 min for equilibration, diabetic hearts from the 12-week animals exhibited significant bradycardia. Bupivacaine 3 mcg.ml-1 did not decrease myocardial contractility in control animals. However, 3 mcg.ml-1 bupivacaine decreased contractility significantly in diabetic animals at nearly all periods. Bupivacaine decreased heart rate and coronary flow significantly and similarly in control and diabetic rats hearts. After pacing at 4 Hz, bupivacaine decreased contractility more in diabetic group than in control group. These results indicate that the presence of a diabetic state appears to enhance the sensitivity of the heart to the myocardial depressant effect of bupivacaine.
authors.affiliation: Department of Anesthesia, Sapporo Tonan Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Imai
authors.forename: K S
authors.initials: KS
authors.lastname: Chang
authors.forename: R D
authors.initials: RD
authors.lastname: Tanz
authors.forename: W C
authors.initials: WC
authors.lastname: Stevens
authors.forename: O
authors.initials: O
authors.lastname: Kemmotsu
mesh_terms: D000818:Animals; D002045:Bupivacaine / Q000494:pharmacology*; D003864:Depression, Chemical; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin
chemical_list: D013311:Streptozocin; D002045:Bupivacaine