[Effects of antiestrogenic drug tamoxifen on human placental secretion of progesterone and human chorionic gonadotropin during early gestation].
Placental villus tissue obtained from pregnant women of 6 to 7 weeks was cultured in vitro for four days, with or without addition of tamoxifen (Tam), an antiestrogenic drug. The levels of both progesterone (P) and human chorionic gonadotropin (hCG) in culture medium collected every day were measured by using radio-immuno assay, so as to observe the effects of Tam on the secretion of P and hCG by villus tissue as well as the time course of these effects. The experimental results showed that the levels of both P and hCG in the culture medium collected on the 3rd and 4th days in the Tam-treated group were significantly lower than those in the control group, indicating that Tam could have a direct inhibitory effect on the secretory function of the placental villus tissue during early pregnancy. The slow onset of the inhibitory effect was in correspondence with the clinical observation that the early pregnancy terminating effect of PGS would be potentiated after 4-5 days of Tam medication. In addition, this inhibitory effect of tamoxifen on the placental secretory function was suggested to be associated with a decrease in the responsiveness of placental tissue to GnRH.
Zhou
M H
MH
Department of Pharmacology, Shanghai Medical University.
Han
G Z
GZ
Chu
Y H
YH
D006063:Chorionic Gonadotropin / Q000378:metabolism*; D002824:Chorionic Villi / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011374:Progesterone / Q000378:metabolism*; D013629:Tamoxifen / Q000494:pharmacology*
D006063:Chorionic Gonadotropin; D013629:Tamoxifen; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone