The small nuclear ribonucleoproteins, SmB and B', are products of a single gene.
Nucleotide sequencing of HeLa genomic DNA amplified by the polymerase chain reaction revealed 696-bp and 841-bp introns within the gene encoding the proteins SmB and SmB', respectively. Since splice consensus sequences were observed flanking the 145-bp insertion detected in the cDNA encoding SmB, we conclude that SmB and SmB' are derived from alternative splicing of a single gene transcript.
Chu
J L
JL
Hospital for Special Surgery, Cornell University Medical Center, New York, NY 10021.
Elkon
K B
KB
D001324:Autoantigens / Q000235:genetics*; D001483:Base Sequence; D005796:Genes; D006367:HeLa Cells; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017411:Ribonucleoproteins, Small Nuclear / Q000235:genetics*; D055517:snRNP Core Proteins
D001324:Autoantigens; D017411:Ribonucleoproteins, Small Nuclear; C526407:SNRPB protein, human; D055517:snRNP Core Proteins