[Monitoring of erection function in patients with prostatic carcinoma treated with Casodex].
This study evaluates the sleep-related erections in 5 patients with locally advanced prostate cancer (T3NOMO) during 6 months treatment with Casodex by multinight continuous monitoring of penile tumescence and rigidity. Mean serum LH, Testosterone and Estradiol levels shown a no statistically significant increase at the six months control. We found no significant modifications in the number of NPT episodes, maximum penile circumference and rigidity time before and after therapy. Penile arterial flow and neurologic examination were also unmodified. All patients had a stable disease and unchanged performance status after 6 months. This pure antiandrogen in a men with prostate cancer does not seem to interfere with self reported libido and erectile capability.
Migliari
R
R
Clinica Urologica Università degli Studi di Cagliari.
Muscas
G
G
Melis
M
M
Garau
M
M
Sorgia
M
M
Scarpa
R M
RM
Usai
E
E
D000726:Androgen Antagonists / Q000627:therapeutic use*; D000813:Anilides / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D004958:Estradiol / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009570:Nitriles; D010410:Penile Erection / Q000187:drug effects*; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy*; D013739:Testosterone / Q000097:blood; D014105:Tosyl Compounds
D000726:Androgen Antagonists; D000813:Anilides; D014408:Biomarkers, Tumor; D009570:Nitriles; D014105:Tosyl Compounds; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; C053541:bicalutamide
Monitoraggio della funzione erettile in pazienti con carcinoma prostatico trattati con Casodex.