[Fibronectin, aging and related pathologies].
It could be demonstrated that plasma and tissue fibronectin (FN) increase with age. Some age dependent diseases as diabetes, osteoarthritis and Werner syndrome produce also an increase of tissue fibronectin biosynthesis. Plasma fibronectin decreases in diabetes and in breast cancer. Alternative splicing of the FN gene appears also to vary with age and in some related pathologies. Nutritional status and UV light also influence FN biosynthesis. It appears therefore that the determination of plasma FN and its isoforms as well as the study of tissue FN may be of interest for the study of chronological aging and related pathologies.
Labat-Robert
J
J
Laboratoire de Biologie du Tissu Conjonctif (URA 1460), Faculté de Médecine, Université Paris.
Chevalier
X
X
D000367:Age Factors; D000375:Aging / Q000378:metabolism*; D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D005353:Fibronectins / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D051379:Mice; D010003:Osteoarthritis / Q000378:metabolism; D012867:Skin / Q000166:cytology; D014898:Werner Syndrome / Q000378:metabolism
D005353:Fibronectins
Fibronectine, vieillissement et pathologies associées.