Adrenergic vasoconstriction limits coronary blood flow during exercise in hypertrophied left ventricle.
This study was carried out to test the hypothesis that alpha-adrenergic vasoconstriction limits coronary blood flow (CBF) during exercise in the chronically pressure overloaded, hypertrophied left ventricle. Studies were performed in dogs in which left ventricular hypertrophy had been produced by banding the ascending aorta at 9 wk of age. Left circumflex coronary artery blood flow and myocardial O2 consumption (MVO2) were examined at rest and during treadmill exercise during control conditions, after selective alpha 1-adrenergic blockade with prazosin, and after nonselective alpha-adrenergic blockade with phentolamine. All studies were performed after beta-adrenergic blockade with propranolol. During control conditions CBF and MVO2 increased progressively during exercise, while coronary sinus O2 tension decreased. Neither prazosin nor phentolamine altered CBF at rest but, in comparison with control measurements, both agents significantly increased CBF during exercise and abolished the decrease in coronary sinus O2 tension that normally occurred during exercise. Both prazosin and phentolamine caused similar significant increases of MVO2 relative to the heart rate times systolic left ventricular pressure during exercise, indicating that the increased CBF produced by these agents enhanced MVO2. Similar findings after prazosin and phentolamine indicate that adrenergic restraint of CBF during exercise resulted principally from alpha 1-adrenergic vasoconstrictions with little additional contribution from postjunctional alpha 2-adrenergic mechanisms.
Bache
R J
RJ
Department of Medicine, University of Minnesota, Minneapolis 55455.
Homans
D C
DC
Dai
X Z
XZ
D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism / Q000503:physiopathology*; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D006352:Heart Ventricles; D006439:Hemodynamics / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010646:Phentolamine / Q000494:pharmacology; D005082:Physical Exertion; D011224:Prazosin / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology*; D014661:Vasoconstriction / Q000502:physiology*
D013566:Sympathomimetics; D010100:Oxygen; D011224:Prazosin; D010646:Phentolamine