[Monitoring of diazepam treatment: comparison of the results of gas chromatography and radioreceptor methods].
26 patients with generalized anxiety disorder have been treated with diazepam (20 mg/24h) for 3 weeks. Blood samples were taken on the days of clinical assessment (before treatment and on the 7th, 14th, 21st day). Determination of drug level was performed parallelly by RRA and GC. The results obtained by both methods agreed well. The intra- and interindividual variations were high. We conclude that diazepam can adequately be measured by both techniques.
Lipska
B
B
Instytut Psychiatrii i Neurologii Warszawie.
Webel
L
L
Sztaniszlav
D
D
Olajos
S
S
Beljajeva
R
R
D001008:Anxiety Disorders / Q000097:blood / Q000188:drug therapy*; D002849:Chromatography, Gas / Q000379:methods; D003975:Diazepam / Q000008:administration & dosage* / Q000097:blood; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods; D005442:Flumazenil; D006801:Humans; D003708:Nordazepam / Q000008:administration & dosage* / Q000097:blood; D011869:Radioligand Assay / Q000379:methods; D014316:Tritium
D014316:Tritium; D005442:Flumazenil; D003708:Nordazepam; D003975:Diazepam
Monitorowane leczenie diazepamem: porównanie wyników uzyskanych metoda chromatografii gazowej i radioreceptorowa.