title: Fetal and maternal plasma atrial natriuretic factor responses to angiotensin II infusion.
abstract: Plasma atrial natriuretic factor and angiotensin II have opposing actions in the regulation of body fluid homeostasis and systemic blood pressure. Angiotensin II infusions stimulate atrial natriuretic factor release in some, but not all, studies in adult mammals. To examine the response during the perinatal period, graded intravenous angiotensin II infusions were administered to four chronically instrumented pregnant ewes and fetuses (132 +/- 1 days of gestation). Fetuses received successive 20-minute intravenous angiotensin II infusions at 25, 50, and 100 ng/kg/min. After a 90-minute recovery, maternal ewes received successive 20-minute angiotensin II infusions (5, 10, and 25 ng/kg/min). During the fetal infusions, mean (+/- SEM) fetal arterial blood pressure (47 +/- 2 to 61 +/- 2 mm Hg, p less than 0.05) and heart rate (155 +/- 16 to 196 +/- 36 beats/min, p less than 0.05) increased, although there was no change in maternal measured parameters. In response to the maternal infusion, maternal mean arterial blood pressure increased (92 +/- 7 to 110 +/- 8 mm Hg, p less than 0.05) and maternal heart rate decreased (136 +/- 4 to 125 +/- 2 beats/min, p less than 0.05) without change in fetal parameters. Fetal plasma atrial natriuretic factor levels (210 +/- 27 to 664 +/- 250 pg/ml, p less than 0.05) significantly increased during the fetal angiotensin II infusions in spite of no change in maternal plasma atrial natriuretic factor (85 +/- 21 to 124 +/- 22 pg/ml) during the maternal angiotensin II infusions. These findings indicate that similar increases in systemic blood pressure in response to angiotensin II infusions stimulate increased fetal, but not maternal, plasma atrial natriuretic factor.
authors.affiliation: Department of Obstetrics and Gynecology, Harbor-University of California-Los Angeles Medical Center, Torrance.
authors.forename: M G
authors.initials: MG
authors.lastname: Ross
authors.forename: J P
authors.initials: JP
authors.lastname: Cardin
authors.forename: L
authors.initials: L
authors.lastname: Castro
authors.forename: M G
authors.initials: MG
authors.lastname: Ervin
authors.forename: R D
authors.initials: RD
authors.lastname: Leake
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects; D003971:Diastole; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006340:Heart Rate, Fetal / Q000187:drug effects; D006706:Homeostasis / Q000502:physiology; D011247:Pregnancy; D012756:Sheep; D013599:Systole
chemical_list: D000804:Angiotensin II; D009320:Atrial Natriuretic Factor