[T-helper cell subsets in patients with inflammatory rheumatic diseases undergoing immunosuppressive therapy].
To determine the influence of immunosuppressive therapy on T-helper-cell subsets in patients with systemic lupus erythematosus and rheumatoid arthritis flow cytometric analysis was performed. Longitudinal studies showed reduced numbers of CD45R+CD4+ lymphocytes in patients treated with cyclophosphamide or azathioprine. Patients receiving steroids had low frequencies of CD29+CD4+ cells. The data suggest that cytotoxic drugs and steroids affect T-helper cells at different activation stages.
Becker
H
H
Medizinische Klinik III und Poliklinik, Universität Giessen.
Potyka
P
P
Weber
C
C
Renelt
M
M
Federlin
K
K
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000188:drug therapy; D001379:Azathioprine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005434:Flow Cytometry; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000188:drug therapy; D013256:Steroids / Q000627:therapeutic use; D006377:T-Lymphocytes, Helper-Inducer
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D013256:Steroids; D003520:Cyclophosphamide; D001379:Azathioprine
T-Helferzell-Subpopulationen von Patienten mit entzündlich-rheumatischen Erkrankungen unter immunsuppressiver Therapie.