title: T-cell receptor isoforms and signal transduction.
abstract: Recent cDNA and genomic cloning have identified CD3 eta as an alternatively spliced product of the same gene locus that encodes CD3 zeta. Three distinct T-cell receptor isoforms have now been identified. A current view of the signal transduction function of these isoforms in thymocytes and T cells is discussed.
authors.affiliation: Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
authors.forename: S
authors.initials: S
authors.lastname: Koyasu
authors.forename: L
authors.initials: L
authors.lastname: D'Adamio
authors.forename: L K
authors.initials: LK
authors.lastname: Clayton
authors.forename: E L
authors.initials: EL
authors.lastname: Reinherz
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000096:biosynthesis / Q000235:genetics; D017252:CD3 Complex; D002118:Calcium / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D014176:Protein Biosynthesis; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D014158:Transcription, Genetic
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D010716:Phosphatidylinositols; D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases; D002118:Calcium