title: High signal intensity in MR images of calcified brain tissue.
abstract: Calcified lesions of the brain occasionally appear bright on T1-weighted MR images. This report shows that particulate calcium can reduce T1 relaxation times by a surface relaxation mechanism. Calcium particles with greater surface area show greater T1 relaxivity. Reduced proton density and reduced T2 tend to diminish signal intensity, but reduced T1 increases signal intensity. Thus, for concentrations of calcium particulate of up to 30% by weight, the signal intensity on standard T1-weighted images increases but subsequently decreases.
authors.affiliation: Department of Medical Biophysics, University of Toronto, Ont, Canada.
authors.forename: R M
authors.initials: RM
authors.lastname: Henkelman
authors.forename: J F
authors.initials: JF
authors.lastname: Watts
authors.forename: W
authors.initials: W
authors.lastname: Kucharczyk
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis*; D002114:Calcinosis / Q000175:diagnosis*; D002119:Calcium Carbonate; D002648:Child; D017886:Durapatite; D005260:Female; D006801:Humans; D006882:Hydroxyapatites; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D013499:Surface Properties
chemical_list: D006882:Hydroxyapatites; D017886:Durapatite; D002119:Calcium Carbonate