title: [Improved control of cisplatin-induced emesis with high-dose metoclopramide, dexamethasone and lorazepam].
abstract: Despite treatment, emesis remains a major problem with cisplatin chemotherapy. Three potent antiemetics, metoclopramide, dexamethasone and lorazepam, were combined in prophylaxis of 18 patients receiving cisplatin based combination chemotherapy. In 75 courses of chemotherapy, 57% experienced complete protection from vomiting and 89% of treatment courses had two or fewer vomiting episodes. Complete protection and mild episodes from nausea was 47% and 53% respectively. Toxicities were mild and infrequent. It was concluded that combination of high-dose metoclopramide, dexamethasone and lorazepam was highly efficacious in preventing nausea and vomiting in moderate or high-dose cisplatin chemotherapy with little side effects.
authors.affiliation: Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital.
authors.forename: Y K
authors.initials: YK
authors.lastname: Mau
authors.forename: Y T
authors.initials: YT
authors.lastname: Li
authors.forename: M S
authors.initials: MS
authors.lastname: Tsui
authors.forename: F C
authors.initials: FC
authors.lastname: Tu
authors.forename: K P
authors.initials: KP
authors.lastname: Hsu
mesh_terms: D002945:Cisplatin / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage* / Q000009:adverse effects; D008787:Metoclopramide / Q000008:administration & dosage* / Q000009:adverse effects; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D003907:Dexamethasone; D008787:Metoclopramide; D008140:Lorazepam; D002945:Cisplatin