title: Duration of immune protection after hepatitis B vaccine in newborns from HBsAg-positive carrier mothers.
abstract: A group of 43 healthy neonates born from HBsAg-positive mothers were evaluated for the presence of protective HBsAb titre after administration of hepatitis B plasma-derived vaccine and hepatitis B hyperimmune-globulin. At 36 months of life we found that a significant number of children had a low HBsAb serum level. This suggests that a close serologic follow-up is necessary to evaluate the optimal timing for the administration of a booster dose of the vaccine.
authors.affiliation: Division of Neonatal Intensive Care-IRCCS-Policlinico S. Matteo, Pavia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Belloni
authors.forename: P
authors.initials: P
authors.lastname: Orsolini
authors.forename: L
authors.initials: L
authors.lastname: Soldini
authors.forename: D
authors.initials: D
authors.lastname: Campisi
authors.forename: A
authors.initials: A
authors.lastname: Chiesa
authors.forename: R
authors.initials: R
authors.lastname: Ciceri
authors.forename: G
authors.initials: G
authors.lastname: Filice
mesh_terms: D002353:Carrier State / Q000276:immunology*; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D006510:Hepatitis B Antibodies / Q000096:biosynthesis / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D017325:Hepatitis B Vaccines; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D016756:Immunoglobulins, Intravenous; D014761:Viral Hepatitis Vaccines