Transplacental transfer of kanamycin to the embryonal or fetal inner ear.
Transplacental distribution of kanamycin (KM) to 35-60 day embryonal or fetal inner ear of the guinea pig following maternal treatment was investigated by an immunohistological technique. KM, administered at any stage of pregnancy, migrated through the placenta and entered into the cochlea. The drug pathway to the organ of Corti seemed to consist of two routes: the spiral vessels and the capillaries of the spiral limbus. However, at an early stage of pregnancy, KM was detected only slightly in the area corresponding to the stria vascularis, probably due to immaturation of strial capillaries.
Yamane
H
H
Department of Otolaryngology, Osaka City University Medical School, Japan.
Nakai
Y
Y
Sakamoto
H
H
Konishi
K
K
Iguchi
H
H
Nakagawa
T
T
Morinaka
K
K
D000818:Animals; D007758:Ear, Inner / Q000187:drug effects* / Q000196:embryology; D005260:Female; D005333:Fetus / Q000187:drug effects; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D007612:Kanamycin / Q000009:adverse effects / Q000493:pharmacokinetics*; D008431:Maternal-Fetal Exchange / Q000502:physiology; D011247:Pregnancy; D013997:Time Factors
D007612:Kanamycin