The role of diacylglycerol/protein kinase C signaling in insulin-stimulated glucose transport.
There seems to be little doubt that insulin rapidly perturbs phospholipid metabolism, and this appears to increase DAG/PKC signaling in many target tissues. Considerable new evidence further suggests that DAG/PKC signaling plays an important role in insulin-stimulated glucose transport. Further studies are needed to test this hypothesis and examine its importance in states of clinical insulin resistance.
Farese
R V
RV
Research Service, J.A. Haley Veterans' Hospital, Tampa, FL.
Standaert
M L
ML
Ishizuka
T
T
Yu
B
B
Arnold
T P
TP
Cooper
D R
DR
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D004075:Diglycerides / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D015398:Signal Transduction
D004075:Diglycerides; D007328:Insulin; D010743:Phospholipids; D011493:Protein Kinase C; D005947:Glucose