Hypertensive diabetic rats: different effects of streptozotocin treatment on blood pressure in adult SHR and in neonatal SHR.
The effect of streptozotocin (STZ) treatment on blood pressure in adult spontaneously hypertensive rats (SHR) was compared with that in neonatal SHR. Three-month-old SHR were intravenously given 10, 30 or 50 mg/kg of STZ. When STZ was given in adult SHR, weight loss, overt hyperglycemia and the reduction of blood pressure occurred dose dependently. Two-day-old pups from SHR were subcutaneously injected with 100 mg/kg of STZ. Neonatal STZ treatment did not attenuate the development of hypertension in SHR. Since neonatally STZ-treated SHR develop mild diabetic symptom with hypertension and develop mild diabetic glomerulosclerosis, they are a good model for studying vascular complications or other disorder relating to the synergism between hypertension and diabetes mellitus.
Sato
T
T
Department of Internal Medicine, Shimane Medical University, Izumo, Japan.
Nara
Y
Y
Kato
Y
Y
Yamori
Y
Y
D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D013311:Streptozocin / Q000494:pharmacology*
D013311:Streptozocin