title: Conopressins and their analogs: synthesis, antidiuretic and behavioral effects.
abstract: [Lys8]-Conopressin G (L1), and [Arg8]-Conopressin S (A1) and their four analogs were synthesized using solid phase procedure. These analogs are [2-thiopropionic acid1, lys8]-conopressin (L2), [2-thiopropionic acid1, Arg8]-conopressin (A2), [cis-4-methyl-1-thiocyclohexaneacetic acid1, Lys8], conopressin (L3), and [cis-4-methyl-1-thiocyclohexaneacetic acid1, ARg8]-conopressin (A3). Behavioral and diuretic effects of all six peptides were compared with these of [Arg8]-vasopressin (AVP). Conopressin A1, and L1 and their analogs A2, A3, L2, L3, induced antidiuretic effects. After icv injection of some conopressins, barrel rotatory behavior of rats was observed.
authors.affiliation: Institute of Chemistry, University of Gdańsk, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Rekowski
authors.forename: U
authors.initials: U
authors.lastname: Galasik-Bartoszek
authors.forename: A
authors.initials: A
authors.lastname: Plech
authors.forename: R
authors.initials: R
authors.lastname: Brus
authors.forename: G
authors.initials: G
authors.lastname: Kupryszewski
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004231:Diuresis / Q000187:drug effects*; D008297:Male; D008969:Molecular Sequence Data; D008978:Mollusk Venoms / Q000138:chemical synthesis / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008978:Mollusk Venoms; D010456:Peptides, Cyclic; D001127:Arginine Vasopressin