5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease.
Interleukin 1 beta in biopsy specimens from inflamed colonic mucosa of patients with active inflammatory bowel disease was studied. Compared with normal colonic mucosal biopsy specimens, a significantly greater amount of interleukin 1 beta was present in rectal mucosa before (median (range) 4.3 (2.0-11.8) v 119.2 (30.1-286.8) pg/mg; p less than 0.01) and produced during organ culture (39.1 (9.4-106.8) v 97.6 (28.2-991.6) pg/mg; p less than 0.01). Values of interleukin 1 beta after culture correlated with concentrations of thromboxane B2. Organ culture of inflamed biopsy specimens in the presence of 5 aminosalicylic acid and dexamethasone reduced the amount of interleukin 1 beta detected. At the doses studied, 5 aminosalicylic acid also reduced the amount of leukotriene B4 detected after culture.
Mahida
Y R
YR
Department of Therapeutics, Queen's Medical Centre, Nottingham.
Lamming
C E
CE
Gallagher
A
A
Hawthorne
A B
AB
Hawkey
C J
CJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000636:Aminosalicylic Acids / Q000494:pharmacology*; D003093:Colitis, Ulcerative / Q000378:metabolism; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D003424:Crohn Disease / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism*; D007375:Interleukin-1 / Q000096:biosynthesis*; D007975:Leukotriene B4 / Q000096:biosynthesis; D008297:Male; D019804:Mesalamine; D008875:Middle Aged; D009924:Organ Culture Techniques; D013427:Sulfapyridine / Q000494:pharmacology; D013929:Thromboxane B2 / Q000096:biosynthesis
D000636:Aminosalicylic Acids; D007375:Interleukin-1; D007975:Leukotriene B4; D019804:Mesalamine; D013929:Thromboxane B2; D003907:Dexamethasone; D013427:Sulfapyridine