[Photodynamic therapy in oncological digestive tract surgery].
Photodynamic therapy is a useful new antitumoral treatment, since it is relatively selective and noniatrogenic. The photosensitizers become preferentially localized in the tumoral tissue, where their excitation by light causes the production of free cytotoxic radicals. If haematoporphyrin derivatives are the most widely used photosensitizers, numerous molecules are being tested. Now used as a palliative photodynamic therapy could logically be used as adjuvant treatment in curative surgical excision. The practical utility of peroperative photodynamic therapy in gastroenterological surgery is being evaluated experimentally and clinically.
Evrard
S
S
Service d'Urgence, CHU, Hôpital Central, Strasbourg.
Aprahamian
M
M
Miehe
J
J
Damge
C
C
Sultan
R
R
Marescaux
J
J
D002734:Chlorophyll / Q000378:metabolism / Q000627:therapeutic use; D004067:Digestive System Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006415:Hematoporphyrins / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D007211:Indoles / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D007430:Intraoperative Care; D054833:Isoindoles; D007834:Lasers; D010778:Photochemotherapy / Q000009:adverse effects / Q000379:methods*
D005609:Free Radicals; D006415:Hematoporphyrins; D007211:Indoles; D054833:Isoindoles; D002734:Chlorophyll; C013647:phthalocyanine
La thérapie photodynamique en chirurgie digestive oncologique.