Postnatal development of thiamine metabolism in rat skeletal muscle.
1. The activities of 2-oxoglutarate dehydrogenase, transketolase, thiamine pyrophosphokinase and thiamine triphosphatase and the concentrations of thiamine phosphates were almost the same between rat extensor digitorum longus and soleus muscles at 2 weeks of age. 2. These enzyme activities changed after 3 weeks of age in a different way depending on the muscle phenotype. 3. Thiamine diphosphate level and the activity of 2-oxoglutarate dehydrogenase increased only in soleus muscle and thiamine triphosphate level increased only in extensor digitorum longus during development.
Matsuda
T
T
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Tonomura
H
H
Baba
A
A
Iwata
H
H
D000375:Aging / Q000378:metabolism; D000818:Animals; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism; D024510:Muscle Development; D009132:Muscles / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013836:Thiamin Pyrophosphokinase / Q000378:metabolism; D013837:Thiamin-Triphosphatase / Q000378:metabolism; D013831:Thiamine / Q000378:metabolism*; D013835:Thiamine Pyrophosphate / Q000378:metabolism; D013838:Thiamine Triphosphate / Q000378:metabolism; D014174:Transketolase / Q000378:metabolism
D013838:Thiamine Triphosphate; D007655:Ketoglutarate Dehydrogenase Complex; D014174:Transketolase; D013836:Thiamin Pyrophosphokinase; D013837:Thiamin-Triphosphatase; D013835:Thiamine Pyrophosphate; D013831:Thiamine