Application of positron emission tomography to neurological oncology.
PET has a promising role in neuroradiology for accurate diagnosis and prognostication of malignant tumors as well as differential diagnosis of radiation necrosis and recurrent tumors. Particularly, PET has proven its ability to accurately differentiate radiation necrosis from recurrent brain tumor. Active tumors have accelerated glycolysis, and a remarkable accumulation of FDG radiotracer in high grade brain tumors is evident on PET images. Tumor metabolism also proportionally increases with increasing pathologic grades of brain tumor, and accelerated tumor metabolism indicates a poor prognosis for the tumor.
Chin
H W
HW
Radiation Therapy, St. Joseph Hospital, Omaha, NE 68131.
Fruin
A H
AH
Bertoni
J M
JM
Frick
M P
MP
Shiue
C Y
CY
McClellan
G
G
Lefkowitz
D
D
Taylon
C
C
Boman
B M
BM
D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging*; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D013702:Temporal Lobe / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed / Q000379:methods*