title: [Significance of HLA genetic factors in the origin of immunologic insufficiency in chronic bronchitis].
abstract: As many as 131 healthy persons (donors) and 83 patients suffering from chronic bronchitis, belonging to the Uzbek nationality were examined. It has been established that there are HLA genetic markers of predisposition and resistance to the development of chronic bronchopulmonary pathology in the population under study. The HLA phenotypic features of patients suffering from chronic bronchitis were reflected in the clinical manifestation of the broncho-obstructive syndrome and at the age of the disease debut. One of the mechanisms of the induction of the bronchopulmonary process in the Uzbek population was revealed by means of simulating the functioning of certain subpopulations of immunocompetent cells.
authors.forename: N M
authors.initials: NM
authors.lastname: Khaitova
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Afanas'ev
authors.forename: R T
authors.initials: RT
authors.lastname: Kadyrova
mesh_terms: D000328:Adult; D001991:Bronchitis / Q000235:genetics / Q000276:immunology*; D002908:Chronic Disease; D004198:Disease Susceptibility; D005819:Genetic Markers / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology; D016130:Immunophenotyping; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D013577:Syndrome; D014610:Uzbekistan
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens
vernacular_title: Znachenie HLA-geneticheskikh faktorov v vozniknovenii immunologicheskoĭ nedostatochnosti pri khronicheskom bronkhite.