Generation of T cell lines with suppressive activity derived from autorosette-forming cells of patients with autoimmune diseases.
A unique subpopulation of human suppressor autorosette-forming T cells was fractionated from peripheral blood of healthy donors and patients with various immune disorders. These cells have been maintained in long-term cultures and evinced suppressor activity in their supernatants. The study indicates the existence of a competitive relationship between the suppressor factors secreted by the cell lines and IL-2. It was found that impaired suppressor function can be related to a decrease in suppressors cell number, impaired function of individual suppressor cells, or failure to respond to active suppressor factors.
Kalechman
Y
Y
C.A.I.R. Institute, Department of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Michlin
H
H
Gafter
U
U
Sredni
B
B
D001327:Autoimmune Diseases / Q000276:immunology*; D002460:Cell Line; D002469:Cell Separation; D002478:Cells, Cultured; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D008213:Lymphocyte Activation; D012016:Reference Values; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*