title: [Aortic valve insufficiency. Diagnosis, course, therapy].
abstract: A radionuclide ventriculographic procedure for the accurate quantification of aortic insufficiency has been developed, and its use in follow-up, pharmacotherapy and surgical planning tested. In 28 patients, follow-up over a period of 20 months revealed only slow progression of the chronic aortic insufficiency; worsening of the symptoms leading to the need for valve replacement was associated with a rapid deterioration of objective parameters. In patients with a stable condition, captopril administered for 4-8 weeks failed to reduce left ventricular overload to any significant extent, while reduction in volume overload was observed in patients with accompanying congestive heart failure or systemic hypertension. Clinical analysis revealed that, as a rule, the indication for valve replacement must be based on follow-up examination. If radionuclide ventriculography reveals a disproportionate enlargement of the ventricle, surgery is indicated even in the absence of symptoms.
authors.affiliation: Abteilung für Kardiologie, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main.
authors.forename: H
authors.initials: H
authors.lastname: Klepzig
authors.forename: G
authors.initials: G
authors.lastname: Hör
authors.forename: M
authors.initials: M
authors.lastname: Kaltenbach
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001022:Aortic Valve Insufficiency / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006332:Cardiomegaly / Q000503:physiopathology; D006350:Heart Valve Prosthesis; D006801:Humans; D015635:Radionuclide Ventriculography
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors
vernacular_title: Aortenklappen-Insuffizienz. Diagnostik, Verlauf, Therapie.