[Colonic polyposis and cancers of the colon. Molecular markers, predisposition and diagnosis of familial forms].
Five to 10% of colorectal carcinomas are obvious inherited familial syndromes. The inherited molecular basis of the predisposition is uniformly present in normal cells of such patients. The identification of the genes underlying cancers, performed with the intent to clone, would first serve as a basis for a pre-symptomatic diagnosis. The APC gene, located on the long arm of chromosome 5, is the only molecular target already identified as involved in the predisposition to familial adenomatous polyposis. Other genes are involved in the progression of sporadic colorectal neoplasias. Their identification would help in the comprehension of colonic carcinogenesis. Molecular analysis of these markers determines improvements in the management of a frequent and most severe disease, in which progress in screening and treatment has been very slow over the past twenty years.
Grandjouan
S
S
Service de gastroentérologie, Hôpital Cochin, Paris, France.
D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000483:Alleles; D002895:Chromosomes, Human, Pair 5; D003110:Colonic Neoplasms / Q000235:genetics*; D003582:Cytogenetics; D005819:Genetic Markers; D006801:Humans; D015335:Molecular Probes; D009857:Oncogenes / Q000235:genetics*
D005819:Genetic Markers; D015335:Molecular Probes
Polypose colique et cancers du côlon. Marqueurs moléculaires, prédisposition, et diagnostic des formes familiales.