Regulated import and degradation of a cytosolic protein in the yeast vacuole.
The key regulatory enzyme in gluconeogenesis, fructose 1,6-bisphosphatase (FBPase) is subject to glucose-stimulated proteolytic degradation in Saccharomyces cerevisiae. This process involves the regulated transfer of FBPase directly from the cytosol into the vacuole or a vacuole-related organelle. Glucose may regulate the production of an FBPase receptor or import factor that is transported to the vacuole through the secretory pathway.
Chiang
H L
HL
Division of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720.
Schekman
R
R
D003600:Cytosol / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism*; D006597:Fructose-Bisphosphatase / Q000302:isolation & purification / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D008970:Molecular Weight; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D014617:Vacuoles / Q000378:metabolism* / Q000648:ultrastructure
D006597:Fructose-Bisphosphatase; D010450:Endopeptidases