[Determination of intact parathyroid hormone in patients with calcium metabolism disorders].
We have used an immunoradiometric assay (IRMA) to measure intact PTH. The serum-levels of PTH followed a log-normal distribution in a population of 85 healthy post-menopausal women, with a geometric mean of 1.9 pmol/l and a range of 0.8-6.1 pmol/l. The correlation between measurements performed using the IRMA and a radioimmunoassay which measured the C-terminal portion of the PTH molecule was 0.85. It was only the IRMA, however, that could measure subnormal values. Two of 27 patients with primary hyperparathyroidism had PTH-values in the upper reference interval. The rest of the patients had elevated levels. Patients with hypercalcemia due to malignancy had subnormal or low normal (less than 2.5 pmol/l) PTH values. Half of the patients with hypoparathyroidism had PTH below the limit of detection. Four subjects with familial hypercalciuric hypercalcemia had normal (3) or slightly elevated PTH-levels.
Birkeland
K I
KI
Hormonlaboratoriet Aker sykehus, Oslo.
Falch
J A
JA
Gautvik
K M
KM
Gjestvang
F T
FT
Holst
N
N
Haug
E
E
D000328:Adult; D002118:Calcium / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000097:blood* / Q000209:etiology; D007011:Hypoparathyroidism / Q000097:blood; D015592:Immunoradiometric Assay / Q000379:methods; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012016:Reference Values
D010281:Parathyroid Hormone; D002118:Calcium
Måling av intakt parathormon hos pasienter med kalsiumforstyrrelser.