[Change in the content of serum immunoglobulins A, G, M in patients with pulmonary tuberculosis and alcoholism during antibacterial and anti-alcoholism therapy].
Serum immunoglobulins A, G, M in 93 patients with pulmonary tuberculosis and suffering from alcoholism at the same time (a core group) were investigated in the course of a combined therapy. A control group consisted of 44 pulmonary tuberculosis patients who were nonalcoholics. Examinations were carried out on their admission to a hospital and 3, 6 and 9-12 months after treatment. The findings proved that the patients of the core group had hyperproduction of main serum immunoglobulins. In the course of a complex antibacterial and antialcoholic therapy the IgA values remained high. A disturbed functional activity of B-lymphocytes is likely to be one of the causes leading to a low efficacy of the tuberculosis treatment among alcoholics.
Maskeev
K M
KM
Kasenova
S L
SL
D000328:Adult; D000437:Alcoholism / Q000150:complications* / Q000276:immunology / Q000628:therapy; D000995:Antitubercular Agents / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000276:immunology; D003131:Combined Modality Therapy; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000188:drug therapy / Q000276:immunology
D000995:Antitubercular Agents; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Izmenenie soderzhaniia syvorotochnykh immunoglobulinov A, G, M u bol'nykh tuberkulezom legkikh i alkogolizmom pri antibakterial'noĭ i antialkogol'noĭ terapii.