GnRH agonist increases pregnancy potential of retrieved oocytes given adequate preincubation before insemination: a comparative study.
Preincubation of oocytes aspirated from follicles in IVF-ET programs is a controversial approach. While some investigators recommend this technique others doubt its necessity. We have studied the embryo quality in 100 women, undergoing IVF-ET, in whom ovulation was induced by the combination of GnRH agonists (GnRHa) and menotropins and compared to a control group in whom ovulation was induced with menotropins alone. No statistically significant difference was noted with regard to the fertilization and cleavage rates as well as to the preincubation period. Significantly higher pregnancy rates (P less than 0.001) were encountered in the first group in comparison with the control group.
Feldberg
D
D
Sherman Fertility Institute, Department of Obstetrics Gynecology, Golda Meir Medical Center (Hasharon Hospital), Petah-Tikva, Israel.
Goldman
G A
GA
Dicker
D
D
Ashkenazi
J
J
Shelef
M
M
Goldman
J A
JA
D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D007315:Insemination, Artificial; D008186:Luteolytic Agents / Q000494:pharmacology*; D008596:Menotropins / Q000494:pharmacology; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy / Q000187:drug effects*; D011446:Prospective Studies; D017329:Triptorelin Pamoate
D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins; D005640:Follicle Stimulating Hormone