title: [Cardiac transplantation: economizing cyclosporin A by including ketoconazole in the immunosuppressive schedule].
abstract: Use of cyclosporin A has improved survival in patients submitted to cardiac transplantation. However, high cost of cyclosporin poses a problem for many patients in Chile. Ketoconazole is able to reduce hepatic metabolism of cyclosporin and thus prolong therapeutic levels. A 74 to 82% reduction in cyclosporin requirements was obtained in a cardiac transplant patient by adding ketoconazole. No renal damage was detected. Therefore, this drug association may help extend cardiac transplantation programs in Chile.
authors.affiliation: Servicio de Cirugía Cardiovascular, Hospital Dr Gustavo Fricke, Viña del Mar, Chile.
authors.forename: E
authors.initials: E
authors.lastname: Becerra
authors.forename: E
authors.initials: E
authors.lastname: Aranguiz
authors.forename: O
authors.initials: O
authors.lastname: Pedemonte
authors.forename: M T
authors.initials: MT
authors.lastname: De Prada
authors.forename: L
authors.initials: L
authors.lastname: Merello
authors.forename: C
authors.initials: C
authors.lastname: Orfali
authors.forename: M
authors.initials: M
authors.lastname: Aninat
authors.forename: H
authors.initials: H
authors.lastname: Torres
authors.forename: R
authors.initials: R
authors.lastname: González
authors.forename: P
authors.initials: P
authors.lastname: Chadid
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008297:Male
chemical_list: D016572:Cyclosporine; D007654:Ketoconazole
vernacular_title: Trasplante cardíaco: ahorro de ciclosporina "A" mediante la asociación de ketoconazol al esquema inmunosupresor.