title: Single-agent chemotherapy for nonmetastatic gestational trophoblastic neoplasia. Perspectives for the 21st century after three decades of use.
abstract: After 30 years of successful chemotherapy for nonmetastatic gestational trophoblastic neoplasia, methotrexate and actinomycin remain the most effective and widely used agents. Though cost effectiveness is a consideration, primary efficacy may be a more important factor in this curable malignant disease. The criteria used for diagnosing neoplasia and for making therapeutic decisions were evaluated critically.
authors.affiliation: Department of Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510.
authors.forename: E I
authors.initials: EI
authors.lastname: Kohorn
mesh_terms: D006063:Chorionic Gonadotropin / Q000097:blood; D003609:Dactinomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D005047:Etoposide / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011379:Prognosis; D012720:Severity of Illness Index; D014328:Trophoblastic Neoplasms / Q000097:blood / Q000145:classification / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000097:blood / Q000145:classification / Q000188:drug therapy*
chemical_list: D006063:Chorionic Gonadotropin; D003609:Dactinomycin; D005047:Etoposide; D005472:Fluorouracil; D008727:Methotrexate