title: Atrial natriuretic peptide and urinary sodium balance during physical exercise.
abstract: Atrial natriuretic peptide (ANP), plasma renin activity (PRA), plasma aldosterone and urinary fractional excretion of sodium (%FENa) were measured in 22 athletes before and after 1 h running. After exercise the hormones increased significantly, while %FENa decreased. In fact, the percent PRA increases resulted higher than the percent ANP increases with a significant inverse correlation. It is concluded that hemodynamic changes during strenuous and prolonged physical exercise lead to the inhibition of the natriuretic properties of ANP by stimulating the renin-angiotensin-aldosterone system, although a feedback mechanism of modulation between ANP and PRA seems to occur.
authors.affiliation: Divisione di Nefrologia, Arcispedale S. Anna, Italia.
authors.forename: E
authors.initials: E
authors.lastname: De Paoli Vitali
authors.forename: F
authors.initials: F
authors.lastname: Malacarne
authors.forename: M
authors.initials: M
authors.lastname: Vedovato
authors.forename: R
authors.initials: R
authors.lastname: Cavallini
authors.forename: B
authors.initials: B
authors.lastname: Bagni
authors.forename: L
authors.initials: L
authors.lastname: Nunzi
authors.forename: P
authors.initials: P
authors.lastname: Gilli
mesh_terms: D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000378:metabolism* / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005246:Feedback / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D012083:Renin / Q000097:blood / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D012964:Sodium / Q000652:urine*
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012964:Sodium; D012083:Renin