[Behavioural adaptation to stress. Improvement by tianeptine].
The aim of this study was to analyse the behaviour effects of tianeptine, an activator of the serotonin neural recapture, in three animal models of depression: immobilization stress, acquired resignation and obligatory swimming. Acute or chronic administration of tianeptine provoked effects comparable to those of the classic antidepressants (tricyclic or atypic). Tianeptine decreased or prevented exploration inhibition induced by immobilization stress, the number of escape failures occurring in a session of adverse and uncontrollable shocks and immobility time following obligatory swimming in a confined space. The relationship between these positive effects of tianeptine and the serotonin system are discussed.
Chaouloff
F
F
Laboratoire de Pharmacologie, CNRS, CHU Necker, Paris.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D012149:Restraint, Physical; D012701:Serotonin / Q000502:physiology; D013315:Stress, Psychological / Q000503:physiopathology*; D013550:Swimming; D013841:Thiazepines / Q000494:pharmacology* / Q000627:therapeutic use
D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine; D012701:Serotonin
Adaptation comportementale au stress. Amélioration par la tianeptine.