title: Synthesis of purine bases having a di(hydroxymethyl)cyclopentenyl group by means of high-pressure reaction and their anti-HIV activity.
abstract: The 1'- and 5'-hydroxymethyl derivatives of carbovir and related purine derivatives were synthesized from 5-hydroxymethylcyclopentadiene. The anti-HIV activity evaluation of these compounds has revealed that 9-(c-4,t-5-dihydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine is a prospective chemotherapeutic agent against AIDS.
authors.affiliation: Pharmaceutical Institute, Tohoku University, Sendai, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Katagiri
authors.forename: M
authors.initials: M
authors.lastname: Nomura
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: C
authors.initials: C
authors.lastname: Tameda
authors.forename: A
authors.initials: A
authors.lastname: Kurimoto
authors.forename: S
authors.initials: S
authors.lastname: Arai
authors.forename: A
authors.initials: A
authors.lastname: Toyota
authors.forename: C
authors.initials: C
authors.lastname: Kaneko
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015224:Dideoxynucleosides / Q000737:chemistry* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D015394:Molecular Structure; D011446:Prospective Studies
chemical_list: D000998:Antiviral Agents; D015224:Dideoxynucleosides; C057503:carbovir; C051061:oxetanocin; D000225:Adenine; D000241:Adenosine; C014174:psicofuranine