Sodium/water intake of rabbits following administration of hormones of stress.
Intracerebroventricular (ICV) infusion of CRF, for 22 h, induced five- to seven-fold increase in the daily intake of sodium chloride solution in wild rabbits. The increased sodium intake persisted for 3 days after the infusion stopped and was accompanied by increased sodium excretion, water turnover and decreased food intake. ICV infusion of CRF also induced a change in the general behaviour of the animals, which lasted throughout the infusion only. Systemic, but not ICV administration of ACTH, similar to systemic administration of adrenal steroid hormones (demonstrated in earlier studies), induced gradual increases in the daily sodium intake and excretion of rabbits, as did restraint by tight jackets. The increased sodium intake was accompanied by increased sodium excretion and water turnover, and lasted as long as the administration of hormones. Together these results lead to the hypothesis that increased sodium intake might be an integral part of the stress reaction of the body and not the consequence of distortions of other regulatory functions.
Tarjan
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Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Denton
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DA
D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D000818:Animals; D002552:Cerebral Ventricles; D003346:Corticotropin-Releasing Hormone / Q000502:physiology*; D004326:Drinking / Q000502:physiology*; D005260:Female; D007263:Infusions, Parenteral; D008297:Male; D010865:Pilot Projects; D011817:Rabbits; D012982:Sodium, Dietary / Q000008:administration & dosage* / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000502:physiology
D012982:Sodium, Dietary; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone