title: Differentiation of human embryonal carcinoma cells induces human immunodeficiency virus permissiveness which is stimulated by human cytomegalovirus coinfection.
abstract: Human immunodeficiency virus (HIV) replicates in differentiated but not undifferentiated NTERA-2 human embryonal carcinoma cells; neither cell type expresses CD4. Susceptibility of the differentiated cells is enhanced by coinfection with cytomegalovirus. HIV infection induces lactoseries glycolipids, suggesting a mechanism whereby HIV might interfere with normal embryogenesis.
authors.affiliation: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104-4268.
authors.forename: G
authors.initials: G
authors.lastname: Hirka
authors.forename: K
authors.initials: K
authors.lastname: Prakash
authors.forename: H
authors.initials: H
authors.lastname: Kawashima
authors.forename: S A
authors.initials: SA
authors.lastname: Plotkin
authors.forename: P W
authors.initials: PW
authors.lastname: Andrews
authors.forename: E
authors.initials: E
authors.lastname: Gönczöl
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D015152:Blotting, Northern; D015704:CD4 Antigens / Q000276:immunology; D002454:Cell Differentiation; D003587:Cytomegalovirus / Q000502:physiology*; D054278:Embryonal Carcinoma Stem Cells; D015683:Gene Products, gag / Q000032:analysis; D006678:HIV / Q000502:physiology*; D015488:HIV Antigens / Q000032:analysis; D016655:HIV Core Protein p24; D006801:Humans; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000382:microbiology; D014758:Viral Core Proteins / Q000032:analysis; D014779:Virus Replication
chemical_list: D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D015683:Gene Products, gag; D015488:HIV Antigens; D016655:HIV Core Protein p24; D014758:Viral Core Proteins