Changes in the level of IL-2, T cell subsets and the function of T suppressor cells in patients with schistosomiasis japonica.
The level of interleukin-2 (IL-2) produced by peripheral blood mononuclear cells in vitro, T cell subsets and the function of T suppressor cells (Ts) in patients with schistosomiasis japonica were investigated. It was found that the level of IL-2 induced by schistosomal antigens was significantly high and positively related to the percentage of CD4+ cells. In the groups of chronic and advanced schistosomiasis japonica, the level of IL-2 induced by schistosomal antigens was markedly lower than that in the group of acute schistosomiasis japonica, but significantly higher than that in the group of normal controls. The IL-2 level was negatively related to the percentage of CD8+ T cells and the ratio of CD4+/CD8+. The level of IL-2 induced by PHA was greatly reduced in the group of advanced schistosomiasis japonica. The changes in the level of IL-2 and its relationship with T cell subsets and the function of Ts are also discussed.
Li
Z J
ZJ
Department of Infectious Diseases, Xiehe Hospital, Tongji Medical University, Wuhan.
Dai
J Z
JZ
Yang
Y X
YX
Zeng
L L
LL
Li
S L
SL
Yang
Q
Q
Wang
H C
HC
Luo
D D
DD
Wang
X H
XH
D016516:CD4-CD8 Ratio; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D012554:Schistosomiasis japonica / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007376:Interleukin-2