Mitogenic response to colony-stimulating factor 1.
The proliferative effects of colony-stimulating factor 1 (CSF-1) on cells of the mononuclear phagocyte lineage are mediated by the CSF-1 receptor tyrosine kinase, which triggers intracellular signal transduction through multiple second messenger pathways. CSF-1 is required throughout G1 to stimulate both immediate- and delayed-early responses that ensure entry of macrophages into S phase. Because CSF-1 induces the expression of different sets of cellular genes during early and late G1, products of the immediate-early response might modulate the effects of ensuing receptor signals to facilitate G1 progression. Targets of the delayed-early response include novel cyclin genes that may play a role in S phase commitment.
Sherr
C J
CJ
Howard Hughes Medical Institute, Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, TN 38105.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006133:Growth Substances / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D016173:Macrophage Colony-Stimulating Factor / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D008264:Macrophages / Q000166:cytology; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics; D008954:Models, Biological; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000235:genetics / Q000502:physiology; D015290:Second Messenger Systems; D014157:Transcription Factors / Q000502:physiology
D006133:Growth Substances; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D016173:Macrophage Colony-Stimulating Factor; D011505:Protein-Tyrosine Kinases; D016186:Receptor, Macrophage Colony-Stimulating Factor