Evaluation of the liver blood flow in the children with portal hypertension.
The aim of the study was to evaluate the liver blood flow at different stages of hepatitis B as compared with prehepatic block. The examination was performed on 79 children aged 1-17 years who were divided in two groups. Group 1 consisted of 20 children with HBV chronic active hepatitis B: 10 children with liver efficiency (Gr. 1A) and 10 with liver cirrhosis (intrahepatic block) Gr. 1B. Group 2 comprised 59 children with prehepatic block. The liver blood flow was assessed with the help of a radioisotope liver scintiscan by the first flow technique using 99mTc-DTPA. The ratio of portal to total liver blood flow (HPI) and time of portal blood flow (T1/2) were estimated. In children from group 1A the HPI mean was 57% (N over 75%) and T1/2 was 7-8 sec (N4-7 sec) depending on age. In Group 1B the HPI mean was 25% and T1/2 was 9-13 sec. In most of the children with prehepatic block HPI was low (mean 22%) and was similar to that in children with cirrhosis due to HBV. The arterial blood flow increased while HPI showed a distinct decrease.
Socha
J
J
Department of Gastroenterology, Child Health Centre, Warszawa, Poland.
Ryzko
J
J
Wróblewska
M
M
Rajszyc
P
P
Konieczny
W
W
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D006509:Hepatitis B / Q000503:physiopathology*; D006521:Hepatitis, Chronic / Q000503:physiopathology*; D006801:Humans; D006975:Hypertension, Portal / Q000503:physiopathology*; D007223:Infant; D008102:Liver Circulation / Q000502:physiology*; D008103:Liver Cirrhosis / Q000503:physiopathology*