Red blood cell NMR proton relaxation times in ill and recovered patients with unipolar and bipolar affective disorders.
Red blood cell NMR relaxation times T1 and T2 and water content were measured in ill and recovered patients with mania, unipolar depressed phase, bipolar depressed phase and control subjects. The results suggest that relaxation times are elevated in ill bipolar manic and ill unipolar depressed patients but are normal in both groups in the recovered phase and in ill bipolar depressed patients. Relaxation times therefore seem to be state-dependent but behave differently in unipolar and bipolar patients.
Besson
J A
JA
Department of Mental Health, University of Aberdeen, U.K.
Holland
J
J
Wheeldon
T
T
Ebmeier
K P
KP
D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D002746:Chlorpromazine / Q000627:therapeutic use; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D007424:Intracellular Fluid / Q000187:drug effects / Q000502:physiology; D008094:Lithium / Q000627:therapeutic use; D016651:Lithium Carbonate; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D016651:Lithium Carbonate; D008094:Lithium; D006220:Haloperidol; D002746:Chlorpromazine