title: [Transplacental passage of Wuchereria bancrofti microfilariae in newborns of microfilaremic mothers].
abstract: The occurrence of circulating Wuchereria bancrofti microfilariae was investigated in 304 pregnant women from the "Unidade Mista Pof. Barros Lima" and "Hospital das Clínicas/UFPE". The filtration technique was employed to detect microfilaraemia during pregnancy, and 13 women were found to be positive (4.2%). The investigation of microfilariae in the cord blood of their children was negative (6/13), and also in venous blood samples collected up to 72 hours after birth and with 6 months of life. Milk samples from these mothers also had no microfilariae. The authors suggest that the occurrence of placentary lesions may be a possible factor involved in the transplacental transfer of microfilariae, and that in utero exposure to microfilariae and/or filarial antigens may influence the response to a filarial infection acquired later, thus being important a clinical and laboratorial follow-up of children exposed previously to filarial antigens during early periods of human development.
authors.affiliation: Centro de Pesquisas Aggeu Magalhães (CPqAM), FIOCRUZ, Recife, Brasil.
authors.forename: M L
authors.initials: ML
authors.lastname: Pires
authors.forename: R S
authors.initials: RS
authors.lastname: Ferreira
authors.forename: S
authors.initials: S
authors.lastname: Araújo
authors.forename: R
authors.initials: R
authors.lastname: Albuquerque
authors.forename: J
authors.initials: J
authors.lastname: Remigio Neto
authors.forename: A S
authors.initials: AS
authors.lastname: Da Silva
authors.forename: G
authors.initials: G
authors.lastname: Dreyer
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001938:Brazil; D004605:Elephantiasis, Filarial / Q000097:blood / Q000635:transmission*; D005260:Female; D005312:Fetal Blood / Q000469:parasitology*; D006801:Humans; D007231:Infant, Newborn; D010865:Pilot Projects; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic; D014958:Wuchereria bancrofti
vernacular_title: Investigação sobre a passagem transplacentária de microfilárias de Wuchereria bancrofti em recém-nascidos de mães microfilarêmicas.