Suppressor cells for antibody production in vivo, induced by bursa cell injection into agammaglobulinemic chickens, belong to A CT4-, CT8+, TCRI- subset of T cells.
The suppressor cells, induced in agammaglobulinemic chickens by injection of bursa cells and capable of inhibiting adoptive antibody production upon cotransfer with bursa cells, were characterized with respect to phenotype. They were found to be CT8+, CT4-, and TCRI- (gamma delta). No evidence could be obtained that histamine type 2 receptor bearing cells were involved in the suppression of antibody formation in vivo.
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Station de Pathologie Aviaire, Institut National de la Recherche Agronomique, Monnaie, France.
Thorbecke
G J
GJ
D000361:Agammaglobulinemia / Q000276:immunology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000917:Antibody Formation; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002003:Brucella abortus / Q000276:immunology; D002060:Bursa of Fabricius / Q000166:cytology* / Q000637:transplantation; D002645:Chickens / Q000276:immunology*; D007114:Immunization; D016219:Immunotherapy, Adoptive; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D013154:Spleen / Q000166:cytology / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000907:Antibodies, Bacterial; D000945:Antigens, Differentiation, T-Lymphocyte; D011948:Receptors, Antigen, T-Cell