U.S. Transuranium Registry report on the 239Pu distribution in a human body.
The distribution of 239Pu in a human whole body is reported. The body contained 246 Bq of 239Pu of which 130 Bq (52.8%) was found in the lungs and associated lymph nodes. Of the remaining 116 Bq (47.2%) that constituted the systemic deposition, 51.2 Bq (44%) were in the skeleton, 48.6 Bq (42%) in the liver, and the remainder (14%) in the rest of the body exclusive of the lungs and associated lymph nodes. An unexpectedly high concentration was observed in the pituitary. The systemic distribution of Pu in this case, when combined with the exposure history, is suggestive of an initial partitioning ratio of 239Pu between skeleton and liver of less than unity, and a tentative initial distribution from the transfer compartment of 25% to the skeleton, 50% to the liver, and 25% to the rest of the body and early excretion is proposed for this case. Older biokinetic models, when used with the available urinalysis data for this case, typically overestimated the deposition when compared with the tissue analysis results, but more recent models provided estimates in close agreement with the autopsy results.
McInroy
J F
JF
Los Alamos National Laboratory, NM 87545.
Kathren
R L
RL
Voelz
G L
GL
Swint
M J
MJ
D008671:Actinoid Series Elements; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011005:Plutonium / Q000493:pharmacokinetics* / Q000652:urine; D012042:Registries; D014018:Tissue Distribution; D014481:United States
D008671:Actinoid Series Elements; D011005:Plutonium