Helper-suppressor T-cell leukemia: unusual phenotype controlled with low-dose deoxycoformycin.
Presented is an unusual case of chronic T-cell leukemia. Immunophenotypic profile revealed the leukemia cells to express T4 and T8 surface markers simultaneously. The patient was treated with low-dose deoxycoformycin and control of symptoms and lymphocyte levels shown to correlate with ADA and dATP/ATP levels.
Adler
M J
MJ
Department of Medicine, UCSD Cancer Center, La Jolla 92093.
Hershberg
R
R
Yu
A
A
D000243:Adenosine Deaminase / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000954:Antigens, Surface / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016130:Immunophenotyping; D015458:Leukemia, T-Cell / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008297:Male; D015649:Pentostatin / Q000008:administration & dosage* / Q000627:therapeutic use; D006377:T-Lymphocytes, Helper-Inducer / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D050378:T-Lymphocytes, Regulatory / Q000201:enzymology / Q000276:immunology / Q000473:pathology*
D000954:Antigens, Surface; D015649:Pentostatin; D000255:Adenosine Triphosphate; D000243:Adenosine Deaminase