Lp(a) interactions.
In this report, we have summarized our recent studies on lipoprotein(a) (Lp(a)) and its interactions with apolipoprotein B-containing lipoproteins (ApoB-Lp). These findings implicate the kringle-4-like domains of Apo(a) in the binding of Lp(a) to other ApoB-Lp and point to proline as important in this interaction. Other studies have indicated that Lp(a) interacts with the subendothelial extracellular matrix (ECM) and that Lp(a) is inversely related to plasma triglycerides. Since Apo(a) also has an affinity for ApoB-Lp, enhanced binding of Apo(a) to the arterial wall could increase the accumulation of LDL in the matrix and thus promote the development of cardiovascular disease.
McConathy
W J
WJ
Lipoprotein and Atherosclerosis Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104.
Trieu
V N
VN
D001054:Apolipoproteins A / Q000378:metabolism; D001055:Apolipoproteins B / Q000378:metabolism; D001667:Binding, Competitive; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D008024:Ligands; D017270:Lipoprotein(a); D008074:Lipoproteins / Q000378:metabolism*; D010958:Plasminogen / Q000378:metabolism; D011392:Proline / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008024:Ligands; D017270:Lipoprotein(a); D008074:Lipoproteins; D014280:Triglycerides; D010958:Plasminogen; D011392:Proline