title: [Disorders of the hypothalamo-hypophyseal system as a cause of infertility in hyperprolactinemia].
abstract: The purpose of the study was to describe hypothalamopituitary functional status of females with infertility in combination with hyperprolactinemia. To this end, changes in prolactin, LH, FSH and TSH in response to the administration of releasing hormones (Gn--RH and TRH) and the dopamine antagonist metoclopramide were assessed in 28 patients with hyperprolactinemic amenorrhea and 5 normal cycling women. Lactotrophs were found to be resistant to functional tests, the resistance increasing as the prolactin level went up. Gonadotrophic and thyrotrophic response to functional tests, on the contrary, increased with the progress of hyperprolactinemia. A conclusion is drawn that stable hyperprolactinemia is a result of disturbance in lactotrophic receptor apparatus, for which reason lactotrophs are no longer sensitive to dophamine inhibiting effect on prolactin secretion.
authors.forename: N V
authors.initials: NV
authors.lastname: Stepanskaia
authors.forename: T V
authors.initials: TV
authors.lastname: Ovsiannikova
authors.forename: T Ia
authors.initials: TIa
authors.lastname: Pshenichnikova
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007247:Infertility, Female / Q000097:blood / Q000209:etiology*; D010907:Pituitary Hormones / Q000097:blood; D011247:Pregnancy
chemical_list: D010907:Pituitary Hormones
vernacular_title: Narushenie gipotalmo-gipofizarníkh vzaimosviazeĭ, kak prichina vesplodiia pri giperprolaktinemii.