[Physical and pharmacokinetic properties of anesthetics and sedatives used in neuroanesthesia and resuscitation].
Pharmacokinetics of anesthetic drugs are widely influenced by their physical properties. Lipo-solubility is the most important characteristic. This parameter conditions tissue diffusion and subsequently potency and duration of action drugs Distribution is unequal in the different compartments of the body. The concept of effective compartment allows a best understanding of relationship between concentration, intensity and duration of action of anesthetic drugs. Constant intravenous infusion route of anesthetic drugs administration requires to be discussed.
Egreteau
J P
JP
Département d'anesthésie-réanimation chirurgicale, Centre hospitalier et universitaire de Brest.
Guedes
Y
Y
L'Azou
D
D
D000765:Anesthesia, Conduction; D000768:Anesthesia, General / Q000379:methods*; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000493:pharmacokinetics*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009493:Neurosurgery; D011485:Protein Binding; D012151:Resuscitation; D012995:Solubility
D000777:Anesthetics; D006993:Hypnotics and Sedatives
Propriétés physiques et pharmacocinétiques des substances anesthésiques et sédatives utilisées en neuroanesthésie et réanimation.