title: Effect of macrophage-derived factor on hypoferraemia induced by Japanese encephalitis virus in mice.
abstract: Depression of serum iron following Japanese encephalitis virus (JEV) infection was observed in mice. The hypoferraemia was associated with the accumulation of iron in reticulo-endothelial cells in the spleen. Splenectomy (compared with sham-operation) prevented the depression in serum iron concentration after JEV infection. It also prevented the rise in levels of liver iron. The effect of JEV-stimulated, splenic macrophage-derived factor (MDF) was evaluated in causing hypoferraemia. MDF produced a rapid reduction in the serum iron levels with accumulation of iron in spleen. These observations suggest that MDF plays a key role in the regulation of iron metabolism during JEV infection.
authors.affiliation: Postgraduate Department of Microbiology, K.G. Medical College, Lucknow, India.
authors.forename: M
authors.initials: M
authors.lastname: Bharadwaj
authors.forename: N
authors.initials: N
authors.lastname: Khanna
authors.forename: A
authors.initials: A
authors.lastname: Mathur
authors.forename: U C
authors.initials: UC
authors.lastname: Chaturvedi
mesh_terms: D000818:Animals; D016207:Cytokines / Q000502:physiology*; D004672:Encephalitis, Japanese / Q000378:metabolism*; D006454:Hemoglobins / Q000032:analysis; D007106:Immune Sera / Q000276:immunology; D016209:Interleukin-8 / Q000502:physiology; D007501:Iron / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008264:Macrophages / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D016207:Cytokines; D006454:Hemoglobins; D007106:Immune Sera; D016209:Interleukin-8; D007501:Iron