Pharmacokinetics of arteether in dog.
A pharmacokinetic study has been conducted in six beagle dogs after i.m. administration of 25 mg/kg of arteether, a qinghaosu (artemisinin) derivative of high anti-malarial activity. Arteether plasma concentrations were measured during a 24 h period using HPLC with an electrochemical detector in the reductive mode. The pharmacokinetic parameters were established using an open two-compartment model. Results showed a relatively rapid absorption phase: T1/2ka was 0.300 +/- 0.096 h and a mean elimination half-life of 27.95 +/- 11.93 h. Cmax was 110 +/- 16 ng/ml, Cltot/F was 1.69 +/- 0.34 ml/min and AUC was 2797 +/- 476 ng/ml/h.
Benakis
A
A
Department of Pharmacology, University of Geneva, Switzerland.
Schopfer
C
C
Paris
M
M
Plessas
C T
CT
Karayannakos
P E
PE
Dondas
I
I
Kotsarelis
D
D
Plessas
S T
ST
Skalkeas
G
G
D000818:Animals; D037621:Artemisinins; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D004563:Electrochemistry; D005260:Female; D006207:Half-Life; D007273:Injections, Intramuscular; D008297:Male; D008954:Models, Biological; D012717:Sesquiterpenes / Q000493:pharmacokinetics*
D037621:Artemisinins; D012717:Sesquiterpenes; C055141:artemotil