Ketoconazole 2% emulsion in the treatment of seborrheic dermatitis.
Fifty patients (42 men, 8 women) with seborrheic dermatitis were included in the trial. Ketoconazole 2% emulsion or the same emulsion without active drug was applied b.i.d. for 4 weeks. Two patients dropped out in the ketoconazole group and nine in the placebo group. Pityrosporum ovale was cultured from all patients at the start and from six out of 23 in the ketoconazole group versus nine out of 16 in the placebo group at week 4. The overall assessment showed a significantly better response to treatment for the ketoconazole emulsion (72%) than for the placebo (32%).
Piérard
G E
GE
Department of Dermatopathology, CHU du Sart Tilman, Liege, Belgium.
Piérard-Franchimont
C
C
Van Cutsem
J
J
Rurangirwa
A
A
Hoppenbrouwers
M L
ML
Schrooten
P
P
D012628:Dermatitis, Seborrheic / Q000188:drug therapy* / Q000382:microbiology; D004311:Double-Blind Method; D004655:Emulsions; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008290:Malassezia / Q000302:isolation & purification; D008297:Male
D004655:Emulsions; D007654:Ketoconazole