[The enhancing effect of calcium ionophore A23187 on the accessory function of mouse dendritic cells].
In this paper, the immunoregulatory effects of calcium ionophore A23187 on the accessory function of mouse spleen dendritic cells (DC) in primary mixed lymphocyte reaction (1.MLR) and oxidative mitogenesis are reported. A23187 had a direct enhancing effect on DC. When pretreated with 0.5-1 mumol/L A23187 for 6-8 h, the accessory activity of DC was twice as high as that of the control. This is circumstantial evidence indicating an up-regulation of activity mediated by an increase in intracellular Ca2+ levels and PKC activation.
Liu
C
C
Institute of Oncology, Beijing.
Zhang
Y
Y
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D003713:Dendritic Cells / Q000187:drug effects* / Q000502:physiology; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000276:immunology; D015854:Up-Regulation / Q000187:drug effects
D000001:Calcimycin