title: [Ceftazidime in common infections in childhood. Experience in 262 cases].
abstract: We analyzed the clinical data collected from an open multicentre study (in 40 Hospital and University centres) with aim to evaluate clinical and bacteriological efficacy and safety of Ceftazidime (CTZ) in common infections of pediatric patients. The data were from 262 patients (137 M, 125 F) mean age 5.13 +/- 3.65 yrs (range 3 m. to 12 yrs). 158 pts with low respiratory tract infection, 32 pts. with upper respiratory tract infection and 72 pts. with urinary tract infection, were treated with CTZ (dose 50 mg/kg/die; i.v. or i.m.) for a mean of 9.4 days. The overall success rate was 96.2% (76.7% cured + 19.5% improved). In the evaluable cases (108) the bacteriological eradication rate was 92.18%. The safety of CTZ was good; adverse events (2 rash and 1 diarrhoea) were observed only in 3 patients. All events had moderate intensity and did not require drug withdrawal.
authors.affiliation: Clinica Pediatrica dell'Università degli Studi di Verona.
authors.forename: V
authors.initials: V
authors.lastname: Fanos
authors.forename: R
authors.initials: R
authors.lastname: Fostini
authors.forename: R
authors.initials: R
authors.lastname: Panebianco
authors.forename: D
authors.initials: D
authors.lastname: Danieli
mesh_terms: D000367:Age Factors; D001424:Bacterial Infections / Q000188:drug therapy; D002442:Ceftazidime / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D002442:Ceftazidime
vernacular_title: Il ceftazidime nelle comune infezioni in età pediatrica. Esperienza di 262 casi.