Role of dopaminergic neurons in denervation-induced alpha 1-adrenergic up-regulation in the rat cerebral cortex.
The density of [3H]prazosin binding to alpha 1-adrenoceptors in the rat cortex was measured after selective and mixed noradrenergic or dopaminergic lesions. DSP-4 produced a selective noradrenergic lesion and increased the density of alpha 1-adrenoceptors. 6-Hydroxydopamine produced a selective dopaminergic lesion (after desipramine protection of noradrenergic neurons) and a mixed noradrenergic and dopaminergic lesion that did not change the cortical alpha 1-adrenoceptor binding. On the basis of the results obtained, a hypothesis is put forward that the central dopaminergic system controls the denervation-induced cortical alpha 1-adrenoceptor up-regulation.
Nowak
G
G
Institute of Pharmacology, Polish Academy of Sciences, Krakow.
Zak
J
J
Superata
J
J
D000818:Animals; D001596:Benzylamines / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism* / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000502:physiology*; D009498:Neurotoxins / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D015854:Up-Regulation
D001596:Benzylamines; D006892:Hydroxydopamines; D009498:Neurotoxins; D011942:Receptors, Adrenergic, alpha; D016627:Oxidopamine; C012102:DSP 4; D004298:Dopamine; D009638:Norepinephrine