Neurofibrillary tangles in dementia pugilistica are ubiquitinated.
Ubiquitin, a protein thought to be involved in the ATP-dependent non-lysosomal degradation of abnormal proteins, has already been identified as a component of neurofibrillary tangles in Alzheimer's disease. We have examined ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica. Neurofibrillary tangles of dementia pugilistica were labelled with an affinity purified antiserum to ubiquitin, and BF10, a monoclonal antibody to a neurofilament epitope.
Dale
G E
GE
Department of Immunology, St. George's Hospital Medical School, London, UK.
Leigh
P N
PN
Luthert
P
P
Anderton
B H
BH
Roberts
G W
GW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology; D001914:Boxing / Q000293:injuries*; D001924:Brain Concussion / Q000473:pathology*; D001925:Brain Damage, Chronic / Q000473:pathology*; D003704:Dementia / Q000473:pathology*; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009454:Neurofibrils / Q000648:ultrastructure*; D009474:Neurons / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology*; D014452:Ubiquitins / Q000032:analysis*
D014452:Ubiquitins