Toxicological study of the molluscicidal latex of Euphorbia splendens: irritant action on skin and eye.
Aqueous solutions of the molluscicidal latex of Euphorbia splendens are irritant to the rabbit eye in concentrations higher than 0.35% and to the rabbit skin in concentrations higher than 0.5%. Although this irritant potential does not preclude its use as a molluscicide, special precautions are recommended for handling and application of the product and the hazard of skin tumor-promoting potential should be carefully investigated before its use for schistosomiasis vector control.
Freitas
J C
JC
Instituto Nacional de Controle de Qualidade em Saúde, Departamento de Farmacologia e Toxicologia, Rio de Janeiro, Brasil.
Presgrave
O A
OA
Fingola
F F
FF
Menezes
M A
MA
Vasconcellos
M C
MC
Schall
V T
VT
Paumgartten
F J
FJ
D000818:Animals; D003231:Conjunctivitis / Q000139:chemically induced*; D003877:Dermatitis, Contact / Q000209:etiology*; D004487:Edema / Q000139:chemically induced; D004890:Erythema / Q000139:chemically induced; D007509:Irritants / Q000633:toxicity*; D007840:Latex / Q000633:toxicity*; D008975:Molluscacides / Q000633:toxicity*; D011817:Rabbits
D007509:Irritants; D007840:Latex; D008975:Molluscacides