In vivo absorption of 14C-glucose and 14C-glycine by the rat intestine during ochratoxin A toxicosis.
Ochratoxin A was administered orally at a dose level of 6 mg/kg/day for eight weeks to rats. Studies on the intestinal cellular macromolecules, activities of membrane bound enzymes and in vivo absorption of 14C-glucose and 14C-glycine exhibited significant alterations. The observed reduction in the absorption of these nutrients during ochratoxin A toxicosis is corroborated by the changes observed in the levels of cellular macromolecules and the activity of membrane bound enzymes which are involved in the transport system.
Subramanian
S
S
Department of Biochemistry, University of Madras, India.
Balasubramanian
N
N
William
S
S
Govindasamy
S
S
D000251:Adenosine Triphosphatases / Q000187:drug effects; D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000187:drug effects; D000818:Animals; D005947:Glucose / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism; D007700:Kinetics; D009793:Ochratoxins / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D009793:Ochratoxins; C025589:ochratoxin A; D000469:Alkaline Phosphatase; D000251:Adenosine Triphosphatases; D005947:Glucose; D005998:Glycine