title: The effect of two sequential doses of Opuntia streptacantha upon glycemia.
abstract: To find out if a second dose of O. streptacantha may enhance its hypoglycemic effect, three tests were performed in fasting condition to 8 type II diabetic subjects and 6 healthy individuals. The tests were as follows: A. 500 g of broiled stems of O. streptacantha were given orally initially and two hours later. B. Only the initial dose. C. Control test with water. Serum glucose and C peptide were measured every two hours from 0 to 6 hours. In diabetic patients a significant (P < 0.01 vs control) decrease of serum glucose reaching from 41 to 46% less than initial value, was noticed in tests A and B, without differences between them. C peptide did not change. In healthy subjects serum glucose and C peptide did not significantly differ between tests. A second dose of O. streptacantha, two hours after the first one, did not improve its hypoglycemic activity.
authors.affiliation: Departament of Internal Medicine, Hospital de Especialidades CMR, México, D.F.
authors.forename: A C
authors.initials: AC
authors.lastname: Frati
authors.forename: N
authors.initials: N
authors.lastname: Xilotl Díaz
authors.forename: P
authors.initials: P
authors.lastname: Altamirano
authors.forename: R
authors.initials: R
authors.lastname: Ariza
authors.forename: R
authors.initials: R
authors.lastname: López-Ledesma
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000628:therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010946:Plants, Medicinal
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents