Normal serum immunoglobulins influence the numbers of bone marrow pre-B and B cells.
The homeostatic mechanisms controlling B lymphocyte output from bone marrow are not well understood. The present experiments evaluated putative influences of circulating immunoglobulins (Ig) on bone marrow (BM) pre-B and B cell populations. Injections into normal mice of Ig isolated from normal mouse serum, resulted in a dose-dependent and reversible reduction in numbers of BM B lineage cells, in particular of small B220+ surface IgM- cells. Maximal effects were observed upon injection of isologous polyclonal Ig and were independent of mature T cells. These results suggest a feedback modulation of peripheral Ig on cellular activities in BM B lineage compartments, mediated by mechanisms that seem to involve the variable regions of the Ig molecule.
Sundblad
A
A
Unité d'Immunobiologie, CNRS URA 359, Institut Pasteur, Paris, France.
Marcos
M
M
Huetz
F
F
Freitas
A
A
Heusser
C
C
Portnoï
D
D
Coutinho
A
A
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D001854:Bone Marrow Cells; D005856:Germ-Free Life; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D007135:Immunoglobulin Variable Region / Q000502:physiology; D007136:Immunoglobulins / Q000502:physiology*; D007958:Leukocyte Count; D008264:Macrophages / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013047:Specific Pathogen-Free Organisms; D013601:T-Lymphocytes / Q000502:physiology
D007135:Immunoglobulin Variable Region; D007136:Immunoglobulins