The origin of estrogens, progesterone, androgens and sex hormone binding globulin in peritoneal fluid in the immediate postovulatory period in normal ovulating women.
In 20 women with proven fertility, one menstrual cycle was monitored by ovarian ultrasonography, laparoscopy and estimation of 17 beta-estradiol (E2), estrone (E1), progesterone, testosterone, androstenedione (Adion), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and sex hormone binding globulin (SHBG) in serum and peritoneal fluid. Three groups were studied, in which the peritoneal fluid was collected within 1, 3 and 5 days after ovulation. E1, E2 and progesterone levels in peritoneal fluid were highest shortly after ovulation and decreased with time. Testosterone and Adion in peritoneal fluid showed no changes, but peritoneal fluid levels were always higher than serum levels. No differences were found between the peritoneal fluid and serum levels of DHEA and DHEAS. SHBG in serum was always higher than in peritoneal fluid. The results are compared with reported steroid levels in follicular fluid from the literature and factors complicating the interpretation of steroid levels in peritoneal fluid are discussed.
Scheenjes
E
E
Division of Obstetrics and Gynecology, University Hospital AZU, The Netherlands.
Thijssen
J H
JH
te Velde
E R
ER
Blankenstein
M A
MA
Kremer
J
J
D000328:Adult; D000728:Androgens / Q000502:physiology*; D000735:Androstenedione / Q000502:physiology; D001202:Ascitic Fluid / Q000737:chemistry*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000502:physiology; D019314:Dehydroepiandrosterone Sulfate; D004958:Estradiol / Q000502:physiology; D004967:Estrogens / Q000502:physiology*; D004970:Estrone / Q000502:physiology; D005260:Female; D015571:Follicular Fluid / Q000737:chemistry; D006801:Humans; D010060:Ovulation / Q000502:physiology*; D011374:Progesterone / Q000502:physiology*; D012738:Sex Hormone-Binding Globulin / Q000502:physiology*; D013739:Testosterone / Q000502:physiology
D000728:Androgens; D004967:Estrogens; D012738:Sex Hormone-Binding Globulin; D004970:Estrone; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D011374:Progesterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate