title: [Progression of functional disability in 70 patients with multiple sclerosis].
abstract: We have carried out a follow-up study in 70 patients that were included in a follow-up protocol when they met the criteria of MS, so as to evaluate the variations in the disability scale per unit of time of follow-up (index of progression) in relation to the several risk factors. There were 31 females and 39 men followed up for 19.6 +/- 12 months. One half of the patients (35) had their first symptoms between 25 and 45 years of age, in 27 the onset was after age 25 and in 8 after age 45. At the end of follow-up 42 patients were classified as having remitting forms, 12 as progressive forms after a remitting phase and 16 as progressive forms from the onset. Significant differences in the evolutive forms were only found in remitting-progressive forms, which had a quicker progression than the purely remitting and chronic progressive forms. The patients who initially had cerebellar symptoms had a quicker progression than those with any other type of presentation. Whereas patients with late onset had a quicker progression than the group with intermediate onset, the patients with early onset had a slower progression.
authors.affiliation: Servicio de Neurología, Hospital Universitario, Sevilla.
authors.forename: G
authors.initials: G
authors.lastname: Izquierdo
authors.forename: M A
authors.initials: MA
authors.lastname: Quesada
authors.forename: G
authors.initials: G
authors.lastname: Navarro
authors.forename: J
authors.initials: J
authors.lastname: Aguilar
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez Moreno
authors.forename: J M
authors.initials: JM
authors.lastname: Girón
authors.forename: C
authors.initials: C
authors.lastname: Martínez-Parra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004185:Disability Evaluation; D006233:Persons with Disabilities; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology*
vernacular_title: Progresión de la incapacidad funcional en 70 pacientes con esclerosis múltiple.