[Immunopathogenesis of Borna disease].
An overview of the pathogenesis of Borna disease (BD) in rats as a model for the naturally occurring infection in horses and sheep is presented. Our findings revealed a virus infection in which a virus-specific T cell-mediated immune response leads to disease. The immune cells capable of mediating this immunopathological reaction were defined as helper/inducer T cells. In all, the described observations indicate that CD4+ T cells and macrophages trigger a delayed-type hypersensitivity reaction and cause BD together with other cells of the immune system.
Stitz
L
L
Institut für Virologie, Justus-Liebig-Universität Giessen.
Richt
J A
JA
Rott
R
R
D000818:Animals; D001890:Borna Disease / Q000209:etiology* / Q000276:immunology; D001891:Borna disease virus / Q000276:immunology; D004195:Disease Models, Animal; D006734:Horse Diseases / Q000209:etiology* / Q000276:immunology; D006736:Horses; D007111:Immunity, Cellular; D051381:Rats; D011917:Rats, Inbred Lew; D012756:Sheep; D012757:Sheep Diseases / Q000209:etiology* / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
Immunpathogenese der Borna-Krankheit.