title: Low frequency maintenance ganciclovir for cytomegalovirus retinitis.
abstract: 45 patients on maintenance ganciclovir for treated cytomegalovirus (CMV) retinitis were reviewed retrospectively. Treatment was given at 30 mg/kg/week in 3 divided doses: Monday, Wednesday, Friday. The median time to clinical relapse was 5.4 months. This is similar to that reported with higher frequency maintenance regimens. The high degree of immunodeficiency (median CD4 count 16 cells/microliters) and poor prognosis (median survival 8.2 months) associated with CMV retinitis were confirmed.
authors.affiliation: University of Melbourne, Department of Ophthalmology, Victoria, Australia.
authors.forename: A J
authors.initials: AJ
authors.lastname: Hall
authors.forename: I D
authors.initials: ID
authors.lastname: Jennens
authors.forename: C R
authors.initials: CR
authors.lastname: Lucas
authors.forename: H
authors.initials: H
authors.lastname: MacLean
authors.forename: A M
authors.initials: AM
authors.lastname: Sandland
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000368:Aged; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy*; D015828:Eye Infections, Viral / Q000150:complications / Q000188:drug therapy*; D015774:Ganciclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications / Q000188:drug therapy; D011379:Prognosis; D012008:Recurrence; D012173:Retinitis / Q000150:complications / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D015774:Ganciclovir