[The role of DL and DH degradation products in the reactions of the plasmin hydrolysis of fibrinogen and fibrin].
The mechanism of effect of plasmin hydrolysis degradation products, fragments DL and DH, on fibrinolysis and fibrinogenolysis processes was investigated on the basis of their various structural and functional characteristics. Using electrophoresis of unreduced samples and degradation products concentrations changing kinetics, DH was shown to be the only fragment which possessed an antifibrinolytic effect. Rauleigh's light scattering analysis indicated the ability of fragments DL and DH to co-form with plasminogen reversible equimolar complexes.
Rozenfel'd
M A
MA
Leonova
V B
VB
Khavkina
L S
LS
D001797:Blood Protein Electrophoresis; D004591:Electrophoresis, Polyacrylamide Gel; D005337:Fibrin / Q000378:metabolism*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism*; D005342:Fibrinolysis; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D008027:Light; D008970:Molecular Weight; D012542:Scattering, Radiation; D013329:Structure-Activity Relationship
D005338:Fibrin Fibrinogen Degradation Products; D005337:Fibrin; D005340:Fibrinogen; D005341:Fibrinolysin
Rol' produktov degradatsii DL i DH v reaktsiiakh plazminovogo gidroliza fibrinogena i fibrina.