title: CNS prophylaxis of childhood leukemia: what are the long-term neurological, neuropsychological, and behavioral effects?
abstract: Current medical treatments for childhood acute lymphoblastic leukemia (ALL) have improved the outlook to where more than 50% can be expected to survive five years or more. The use of CNS prophylaxis has contributed in a significant way to these improved survival statistics by reducing the likelihood of CNS relapses. The literature relating to the potential adverse psychological consequences of CNS prophylaxis, which include cranial radiation therapy (CRT), is reviewed and analyzed. The majority of published papers of children in first remission report that CNS prophylaxis, which include both CRT and intrathecal methotrexate, results in a variety of learning problems in many children who were younger than age 5 when treated. The available literature on the social, emotional, and educational sequelae of childhood ALL is also reviewed.
authors.affiliation: University of Iowa, Iowa City.
authors.forename: J A
authors.initials: JA
authors.lastname: Stehbens
authors.forename: T A
authors.initials: TA
authors.lastname: Kaleita
authors.forename: R B
authors.initials: RB
authors.lastname: Noll
authors.forename: W E
authors.initials: WE
authors.lastname: MacLean
authors.forename: R T
authors.initials: RT
authors.lastname: O'Brien
authors.forename: M J
authors.initials: MJ
authors.lastname: Waskerwitz
authors.forename: G D
authors.initials: GD
authors.lastname: Hammond
mesh_terms: D001921:Brain / Q000187:drug effects* / Q000528:radiation effects*; D001925:Brain Damage, Chronic / Q000209:etiology*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D002648:Child; D002653:Child Behavior Disorders / Q000209:etiology*; D016371:Cranial Irradiation; D005500:Follow-Up Studies; D006801:Humans; D007278:Injections, Spinal; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009483:Neuropsychological Tests; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology*; D014888:Wechsler Scales
chemical_list: D008727:Methotrexate