title: Antibodies against the cytoplasmic tail can differentiate between the quaternary forms of the Mr 46,000 mannose 6-phosphate receptor.
abstract: An antiserum against a peptide of the cytoplasmic tail of the Mr 46,000 mannose 6-phosphate receptor is described which recognizes preferentially the tetrameric versus the dimeric form of this receptor. This indicates that the conformation of the cytoplasmic tail, which harbours signals necessary for the trafficking of the receptor, depends on the quaternary structure of the receptor.
authors.affiliation: Georg-August-Universität, Abt. Biochemie, Göttingen, Germany.
authors.forename: S K
authors.initials: SK
authors.lastname: Nadimpalli
authors.forename: B
authors.initials: B
authors.lastname: Schmidt
authors.forename: K
authors.initials: K
authors.lastname: von Figura
authors.forename: A
authors.initials: A
authors.lastname: Hille
mesh_terms: D000906:Antibodies / Q000276:immunology*; D003593:Cytoplasm / Q000276:immunology; D006801:Humans; D008099:Liver / Q000276:immunology*; D008970:Molecular Weight; D011233:Precipitin Tests; D011487:Protein Conformation; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000276:immunology
chemical_list: D000906:Antibodies; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface