Identification of a previously unrecognized production site of human renin.
We found expression of the renin gene in the intestine of human, mouse and the transgenic mouse in which the 3' flanking sequences of the human renin gene function as a tissue-specific promoter. A cotransfection analysis showed that the promoter is activated by the product of adenovirus E1A 13S mRNA in cells originated from extrarenal tissues.
Seo
M S
MS
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
Fukamizu
A
A
Saito
T
T
Murakami
K
K
D000256:Adenoviridae / Q000235:genetics; D017456:Adenovirus Early Proteins; D000818:Animals; D015152:Blotting, Northern; D005786:Gene Expression Regulation / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D007082:Ileum / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012083:Renin / Q000235:genetics*; D012260:Ribonucleases / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics; D014162:Transfection / Q000235:genetics
D017456:Adenovirus Early Proteins; D009856:Oncogene Proteins, Viral; D014157:Transcription Factors; D012260:Ribonucleases; D012083:Renin