title: Infra-additivity of combined treatments with selective D1 and D2 receptor antagonists for inhibiting sucrose reinforcement.
abstract: Selective antagonists of either the D1 receptor (SCH 23390) or of the D2 receptor (raclopride) produce a dose-related inhibition of sucrose sham feeding in the rat. We investigated the effect of combined treatments with these antagonists on sucrose sham feeding and observed infra-additivity of inhibition across a range of doses. On the basis of this observed occlusive relationship, we conclude that the relevant D1 and D2 receptor mechanisms mediating sweet taste reward do not function independently.
authors.affiliation: Department of Psychiatry, New York Hospital-Cornell Medical Center, Edward W. Bourne Behavioral Research Lab, White Plains 10605.
authors.forename: L H
authors.initials: LH
authors.lastname: Schneider
authors.forename: C A
authors.initials: CA
authors.lastname: Watson
authors.forename: J
authors.initials: J
authors.lastname: Gibbs
authors.forename: G P
authors.initials: GP
authors.lastname: Smith
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D020891:Raclopride; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D012054:Reinforcement, Psychology; D012201:Reward; D012457:Salicylamides / Q000494:pharmacology*; D013395:Sucrose
chemical_list: D001552:Benzazepines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D012457:Salicylamides; D020891:Raclopride; D013395:Sucrose