Determination of clarithromycin as a contaminant on surfaces by high-performance liquid chromatography using electrochemical detection.
Microgram levels of clarithromycin residues on various surfaces are quantitated. After cleaning, any residual clarithromycin remaining is removed from the surface by a wet swab-dry swab technique. High-performance liquid chromatography with electrochemical detection is used for quantitation of the resulting solutions. Recoveries ranged from 93 to 118%.
Rotsch
T D
TD
Analytical Research Department, Abbott Laboratories, North Chicago, Illinois 60064.
Spanton
M
M
Cugier
P
P
Plasz
A C
AC
D002851:Chromatography, High Pressure Liquid; D017291:Clarithromycin; D004340:Drug Contamination; D004563:Electrochemistry; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000032:analysis
D004917:Erythromycin; D017291:Clarithromycin