Comparative effects of 2.5 and 5 mg cilazapril versus placebo on daily blood pressure load.
The antihypertensive efficacy of 2.5 and 5 mg cilazapril and placebo in lowering 24-h ambulatory blood pressure (ABP) and BP load were compared in 42 patients with mild to moderate hypertension. After a 2-week placebo run-in period, patients were randomized double-blind to receive either 2.5 mg cilazapril (n = 14), 5 mg cilazapril (n = 14), or placebo (n = 14) for 4 weeks. There were no significant differences in 24-h and awake ABP or in office BP between 2.5 and 5 mg cilazapril. Moreover, the percentage of patients that had BP control (mean daytime ABP less than 90 mm Hg) was 14% in the placebo group, 64% and 71% with 2.5 and 5 mg cilazapril, respectively. Furthermore, the percentage of BP load was similar with both regimens (29 v 36%). These observations indicate that 2.5 and 5 mg cilazapril have equipotent antihypertensive efficacy.
Poirier
L
L
Hypertension Unit, Centre Hospitalier de l'Université Laval, Ste-Foy, Québec, Canada.
Pyzyk
M
M
Provencher
P
P
Lacourcière
Y
Y
D000704:Analysis of Variance; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000592:standards / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D017315:Cilazapril; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011724:Pyridazines / Q000494:pharmacology* / Q000592:standards / Q000627:therapeutic use
D000806:Angiotensin-Converting Enzyme Inhibitors; D011724:Pyridazines; D017315:Cilazapril