Atrial natriuretic factor stimulates in-vivo and in-vitro secretion of cortisol in teleosts.
Atrial natriuretic factor (ANF) has been shown to increase circulating cortisol levels in cannulated, free-swimming seawater (SW)-adapted flounders. Increases were apparent within 30 min of i.v. injection of human ANF (hANF;10 micrograms/kg bw) and the increase in plasma cortisol was maintained throughout the 5h experimental period. No such increase was observed in vehicle-injected controls. This apparent steroidogenic effect of ANF was supported by an ANF-induced increase in in-vitro secretion of cortisol by interrenal tissue from SW-adapted trout. By contrast hANF had no significant effect on tissue derived from freshwater adapted trout. An ANF-induced increase in plasma cortisol by a direct effect on interrenal steroidogenesis in SW teleosts would be an appropriate response for survival in hypertonic media.
Arnold-Reed
D E
DE
Department of Physiological Sciences, University of Manchester.
Balment
R J
RJ
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D005432:Flounder / Q000502:physiology*; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D014337:Trout / Q000502:physiology*
D009320:Atrial Natriuretic Factor; D006854:Hydrocortisone