title: Ventricular enlargement and remodeling following acute myocardial infarction: mechanisms and management.
abstract: Severe myocardial ischemia, when sustained, leads to a predictable sequence of events, including myocardial necrosis, expansion of the infarct, and later its replacement by scar tissue. The nonischemic tissue sustains ventricular function, but it frequently adapts to the extra load placed on it by dilating. The enlargement and remodeling of the left ventricle may lead to ventricular failure and arrhythmias. Rational management to prevent these complications includes restoration of the patency of the occluded vessel and ventricular unloading. These two interventions may be useful both early and late in the course of infarction.
authors.affiliation: Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115.
authors.forename: E
authors.initials: E
authors.lastname: Braunwald
authors.forename: M A
authors.initials: MA
authors.lastname: Pfeffer
mesh_terms: D006332:Cardiomegaly / Q000209:etiology* / Q000517:prevention & control; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*