Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle.
Continuous infusion of quinolinic acid (QA) at low doses into the lateral ventricle has been previously shown to cause a reduction of the hippocampal and cortical ChAT activities in rats although GAD activities were unchanged. In the present study, we have studied behavioral changes in rats with continuous infusion of QA in an active avoidance task. Acquisition of active avoidance was significantly impaired in rats with QA infusion compared to control. These results suggest that continuous infusion of QA is a useful technique for the study of chronic neurodegenerative diseases associated with memory impairment.
Yamada
K
K
Department of Chemical Pharmacology, Faculty of Pharmaceutial Sciences, Meijo University, Nagoya, Japan.
Nabeshima
T
T
Kameyama
T
T
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D003292:Convulsants / Q000009:adverse effects*; D004195:Disease Models, Animal; D007276:Injections, Intraventricular; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains
D003292:Convulsants; D011805:Quinolinic Acids; D017378:Quinolinic Acid