Inhibition of endothelin-induced bronchoconstriction by OKY-046, a selective thromboxane A2 synthetase inhibitor, in guinea pigs.
Nambu
F
F
Minase Research Institute, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Yube
N
N
Omawari
N
N
Sawada
M
M
Okegawa
T
T
Kawasaki
A
A
Ikeda
S
S
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001285:Atropine / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D016084:Bronchoconstriction / Q000187:drug effects*; D002867:Chromones / Q000494:pharmacology; D016232:Endothelins / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000502:physiology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008689:Methacrylates / Q000494:pharmacology*; D011738:Pyrilamine / Q000494:pharmacology; D013929:Thromboxane B2 / Q000096:biosynthesis; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D001095:Arachidonic Acids; D001643:Bridged Bicyclo Compounds; D002867:Chromones; D016232:Endothelins; D005229:Fatty Acids, Monounsaturated; D008689:Methacrylates; C067427:ONO 8809; D016718:Arachidonic Acid; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D001285:Atropine; D006632:Histamine; D013930:Thromboxane-A Synthase; D011738:Pyrilamine; C034364:ozagrel; C047681:pranlukast; D007213:Indomethacin