title: Induction of Fc epsilon RII/CD23 on human T cells by excretory and secretory antigen of Dirofilaria immitis.
abstract: We investigated the capacity of excretory and secretory antigen (ES) derived from living filarial worms in the induction of CD23 expression on human peripheral blood T cells by using flow cytometry. ES (10 micrograms/ml) significantly induced the expression of CD23 on human T cells. Moreover, increased CD23 expression was completely abolished by preincubation with specific antibody to ES. The results suggest that ES might play a certain role in IgE antibody production by induction of CD23 expression on T cells.
authors.affiliation: Department of Medical Zoology, Tokyo Medical and Dental University, Japan.
authors.forename: K A
authors.initials: KA
authors.lastname: Yamaoka
authors.forename: S
authors.initials: S
authors.lastname: Tsukidate
authors.forename: M
authors.initials: M
authors.lastname: Higaki
authors.forename: N
authors.initials: N
authors.lastname: Miyasaka
authors.forename: K
authors.initials: K
authors.lastname: Fujita
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology*; D004183:Dirofilaria immitis / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D011961:Receptors, Fc / Q000276:immunology*; D017455:Receptors, IgE; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D000947:Antigens, Helminth; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E