Complete androgen deprivation prior to radical prostatectomy in patients with stage T3 cancer of the prostate.
Twenty-one patients with stage T3 cancer of the prostate underwent complete androgen deprivation (LH-RH agonist and flutamide) for 3 months prior to radical prostatectomy. Two problems were to be dealt with: the decrease in the volume of the prostate, and the possibility of downstaging (= pT less than pT3 according to the UICC 1987 classification) of the prostatic cancer. A decrease in the volume was noted in each case. A downstaging effect (pT in comparison to T stage) was noted in 33% of the patients. The downstaging effect was noted in 75% of grade 1 tumor, in 31% of grade 2 tumors, but not in grade 3 tumors.
Flamm
J
J
Department of Urology, Wilhelminenspital, Vienna, Austria.
Fischer
M
M
Höltl
W
W
Pflüger
H
H
Tomschi
W
W
D000368:Aged; D002064:Buserelin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005485:Flutamide / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000187:drug effects; D017273:Goserelin; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011300:Preoperative Care; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D013997:Time Factors
D017273:Goserelin; D007987:Gonadotropin-Releasing Hormone; D005485:Flutamide; D002064:Buserelin