[Correlations between total protein level in the cell and its proliferative activity--an important biological and clinical problem].
The development of investigations method making possible evaluation of the intracellular protein content in the cytoplasm and the occurrence of successive phases of cell division, in particular DNA replication and mitosis. After exposure of the cell to certain chemical or biological factors, e.g. cytostatic drugs, DNA replication and mitosis and the biosynthesis of cytoplasmic macroparticles may be dissociated. Determination of the values of the fractions with low protein content in the cell population in acute leukaemia, that is the percent of cells with cytoplasmic protein below the values observed in phase S, may be clinically important as a prognostic factor in this group of diseases.
Wołowiec
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Katedry i Kliniki Hematologii i Chorób Rozrostowych AM we Wrocławiu.
D002455:Cell Division / Q000502:physiology; D003593:Cytoplasm / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000097:blood* / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000097:blood*; D008214:Lymphocytes / Q000473:pathology* / Q000648:ultrastructure; D009363:Neoplasm Proteins / Q000097:blood*; D012334:RNA, Neoplasm / Q000097:blood* / Q000502:physiology
D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm
Współzalezność pomiedzy zawartościa białka całkowitego w komórce a jej aktywnościa podziałowa--wazny problem biologiczny i kliniczny.