Adrenal androgen secretion and biologic effects.
This article reviews the physiology of adrenal androgen secretion. The effects of glucocorticoid administration, age, stress, and other drugs on the secretion of adrenal androgens are discussed. The biologic effects of dehydroepiandrosterone on cytokine secretion by lymphocytes, reduction of neoplasia, obesity, and endothelial injury and stimulation of bone growth appear to be unexplained by metabolism of this adrenal androgen to other steroid hormone, suggesting that dehydroepiandrosterone is a steroid hormone.
Meikle
A W
AW
University of Utah School of Medicine, Salt Lake City.
Daynes
R A
RA
Araneo
B A
BA
D000302:Adrenal Cortex / Q000378:metabolism*; D000728:Androgens / Q000096:biosynthesis / Q000378:metabolism* / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D003687:Dehydroepiandrosterone / Q000494:pharmacology; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D011485:Protein Binding; D014018:Tissue Distribution
D000728:Androgens; D003687:Dehydroepiandrosterone