[Cardiovascular risks induced by estrogens prescribed at low doses. 208 years of observation--137 patients].
The cardiovascular risk induced by oestrogen treatment appears to be minimal when oestrogens are prescribed at low doses (daily dose less than 3 mg/day) and when this drug is not prescribed in patients with a history of cardiovascular disease. The Prostatic Cancer Cooperative Study Group compared the course of 137 patients treated by oestrogens with a French male population matched for age: ten accidents were observed versus nine expected and one death was observed versus 3 expected. By selecting patients, oestrogens can therefore still be part of the range of treatments available for advanced prostatic cancer.
Chevret
S
S
Département d'informatique et de biostatistique médicale, Hôpital Saint-Louis, Paris, France.
Chastang
C
C
D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000145:classification / Q000453:epidemiology*; D016022:Case-Control Studies; D002423:Cause of Death; D015331:Cohort Studies; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D012307:Risk Factors; D013997:Time Factors
D004967:Estrogens
Risque cardiovasculaire induit par les oestrogènes prescrits à faibles doses. 208 ans d'observation--137 malades.