title: Early anti-HBs antibody response to accelerated and to conventional hepatitis B vaccination regimens in healthy persons.
abstract: A significantly higher prevalence of a protective concentration of anti-HBs was achieved at 1 and 2 months among 132 healthy medical students who received an accelerated vaccination schedule with a recombinant hepatitis B vaccine (Engerix-B) than among 120 medical students who received a conventional regimen. With the accelerated schedule, however, 60% students at 1 month and 27% at 2 months were still unprotected (anti-HBs titre less than 10.0 IU/l). Additional passive immunisation should therefore continue to be offered if the accelerated schedule is adopted for post-exposure prophylaxis.
authors.affiliation: Regional Infectious Disease Unit, Fazakerley Hospital, Liverpool, U.K.
authors.forename: A D
authors.initials: AD
authors.lastname: Harries
authors.forename: M
authors.initials: M
authors.lastname: Clark
authors.forename: N J
authors.initials: NJ
authors.lastname: Beeching
authors.forename: J
authors.initials: J
authors.lastname: Lavelle
authors.forename: K J
authors.initials: KJ
authors.lastname: Mutton
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D003276:Contraceptives, Oral; D005260:Female; D006508:Hepatitis Antibodies / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology* / Q000517:prevention & control; D017325:Hepatitis B Vaccines; D006801:Humans; D008297:Male; D012907:Smoking; D014611:Vaccination; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D003276:Contraceptives, Oral; D006508:Hepatitis Antibodies; D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines