MK-801, a non-competitive NMDA receptor antagonist, produces facilitation of the micturition reflex in awake, freely-moving rats.
MK-801 (dizocilpine), a non-competitive N-methyl-D-aspartate (NMDA) receptor blocker, produced a dose-dependent (30-120 micrograms/kg, i.v.) increase in the frequency of micturition (as well as the already described behavioral effects) in awake, freely-moving rats. The contraction amplitude was also slightly increased. In contrast, MK-801 administered to urethane-anesthetized rats resulted in complete inhibition of bladder contractions. The effect of MK-801 on the frequency of bladder contractions, therefore, is anesthetic dependent. Excitatory amino acids acting at NMDA receptors may play a role in the control of micturition.
Vera
P L
PL
VA Medical Center, Pittsburgh, PA 15240.
Nadelhaft
I
I
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000502:physiology; D012018:Reflex / Q000187:drug effects*; D013268:Stimulation, Chemical; D014520:Urethane / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects; D014554:Urination / Q000187:drug effects*; D014851:Wakefulness
D000777:Anesthetics; D016194:Receptors, N-Methyl-D-Aspartate; D014520:Urethane; D016291:Dizocilpine Maleate