title: In vitro photodynamic inactivation of herpes simplex virus with sapphyrins: 22 pi-electron porphyrin-like macrocycles.
abstract: The photodynamic inactivation of HSV-1, a virus having a membranous envelope, with both a decaalkyl sapphyrin and its dicarboxy-substituted analog was studied. The decaalkyl sapphyrin was as efficient in the inactivation of HSV-1 on a per macrocycle basis as DHE, whereas the efficiency of the dicarboxy-substituted sapphyrin was approximately two orders of magnitude less. Fluorescence studies of sapphyrin's binding to liposomes and VSV suggested that the decaalkylsapphyrin bound monomerically to cholesterol-rich regions of the viral envelope, whereas its charged analog localized in a more polar environment.
authors.affiliation: Baylor Research Foundation, Baylor University Medical Center, Dallas, TX 75226.
authors.forename: M M
authors.initials: MM
authors.lastname: Judy
authors.forename: J L
authors.initials: JL
authors.lastname: Matthews
authors.forename: J T
authors.initials: JT
authors.lastname: Newman
authors.forename: H L
authors.initials: HL
authors.lastname: Skiles
authors.forename: R L
authors.initials: RL
authors.lastname: Boriack
authors.forename: J L
authors.initials: JL
authors.lastname: Sessler
authors.forename: M
authors.initials: M
authors.lastname: Cyr
authors.forename: B G
authors.initials: BG
authors.lastname: Maiya
authors.forename: S T
authors.initials: ST
authors.lastname: Nichol
mesh_terms: D000818:Animals; D008027:Light; D008081:Liposomes; D011758:Pyrroles / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D014709:Vero Cells
chemical_list: D008081:Liposomes; D011758:Pyrroles; D011838:Radiation-Sensitizing Agents