title: [T-helper cell subsets in patients with inflammatory rheumatic diseases undergoing immunosuppressive therapy].
abstract: To determine the influence of immunosuppressive therapy on T-helper-cell subsets in patients with systemic lupus erythematosus and rheumatoid arthritis flow cytometric analysis was performed. Longitudinal studies showed reduced numbers of CD45R+CD4+ lymphocytes in patients treated with cyclophosphamide or azathioprine. Patients receiving steroids had low frequencies of CD29+CD4+ cells. The data suggest that cytotoxic drugs and steroids affect T-helper cells at different activation stages.
authors.affiliation: Medizinische Klinik III und Poliklinik, Universität Giessen.
authors.forename: H
authors.initials: H
authors.lastname: Becker
authors.forename: P
authors.initials: P
authors.lastname: Potyka
authors.forename: C
authors.initials: C
authors.lastname: Weber
authors.forename: M
authors.initials: M
authors.lastname: Renelt
authors.forename: K
authors.initials: K
authors.lastname: Federlin
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000188:drug therapy; D001379:Azathioprine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005434:Flow Cytometry; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000188:drug therapy; D013256:Steroids / Q000627:therapeutic use; D006377:T-Lymphocytes, Helper-Inducer
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D013256:Steroids; D003520:Cyclophosphamide; D001379:Azathioprine
vernacular_title: T-Helferzell-Subpopulationen von Patienten mit entzündlich-rheumatischen Erkrankungen unter immunsuppressiver Therapie.