title: [Myocardial infarct and angiographically normal coronary arteries].
abstract: Myocardial infarction and normal coronary arteries is not a rare event in the ischemic heart disease. Even if the patients with acute myocardial infarction and angiographically normal coronary arteries represent a small percentage (reported incidence varies from 1% to 12%) of all patients with acute ischemic attacks, they might be useful to highlight the pathogenetic mechanisms of this syndrome. To improve the understanding of this clinical entity, we reviewed our experience of 18 patients with myocardial infarction and normal coronary arteries. They were compared with a control group of patients with similar clinical characteristics (gender, age, infarct location) and residual coronary artery stenosis. The myocardial damage was less extensive in patients without residual stenosis (peak CK-MB: 56.1 +/- 71.9 vs 126.5 +/- 87.9 IU/I, p < 0.05), with a better left ventricular function either global (ejection fraction: 64 +/- 11 vs 55 +/- 13%, p < 0.05) and regional (SD/chord: -1.36 +/- 1.20 vs -2.42 +/- 1.04, p < 0.02). These findings probably reflect a more prompt and complete reperfusion of the infarct related artery. Myocardial necrosis may occur without obstructive coronary artery disease by the interaction of multiple factors such as abnormal platelet aggregation, thrombus formation and localized or diffuse changes of coronary vascular tone.
authors.affiliation: Divisione Clinicizzata di Cardiologia, Università degli Studi, Verona.
authors.forename: C
authors.initials: C
authors.lastname: Vassanelli
authors.forename: G
authors.initials: G
authors.lastname: Menegatti
authors.forename: G
authors.initials: G
authors.lastname: Zanotto
authors.forename: G
authors.initials: G
authors.lastname: Canali
authors.forename: G
authors.initials: G
authors.lastname: Morando
authors.forename: M
authors.initials: M
authors.lastname: Turri
authors.forename: L
authors.initials: L
authors.lastname: Zanolla
authors.forename: G
authors.initials: G
authors.lastname: Destro
authors.forename: E
authors.initials: E
authors.lastname: Barbieri
authors.forename: G P
authors.initials: GP
authors.lastname: Nidasio
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D017023:Coronary Angiography / Q000706:statistics & numerical data; D003327:Coronary Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology
vernacular_title: L'infarto miocardico a coronarie angiograficamente normali.