title: Birthweight of babies born to mothers with type 1 diabetes: is it related to blood glucose control in the first trimester?
abstract: A retrospective study of 133 pregnancies in women with Type 1 diabetes was performed, and the 116 which progressed beyond 28 weeks were further analysed. Despite good maternal blood glucose control (mean (+/- SE) HbA1 levels 8.6 +/- 0.2% at the end of the first trimester; 6.9 +/- 0.2% at delivery; normal range 4.0-8.5%), 38% of babies had birthweights above the 90th centile and operative intervention occurred in 77 deliveries (66%). There was no significant correlation between birthweight and HbA1 level at any stage of pregnancy, but mothers with babies above the 90th centile for weight had a higher HbA1 at the end of the first trimester than mothers with babies below the 90th centile (9.3 +/- 0.5 vs 7.9 +/- 0.2%, p less than 0.05). In contrast there was no difference in the HbA1 levels at delivery (7.0 +/- 0.3 vs 6.8 +/- 0.2%). The perinatal mortality rate was 17.7 per 1000 births. The results confirm that in Type 1 diabetes large babies are common despite good blood glucose control, and suggest that maternal blood glucose control in the first trimester may be an important determinant of birthweight.
authors.affiliation: Leicester Royal Infirmary, UK.
authors.forename: R W
authors.initials: RW
authors.lastname: Peck
authors.forename: D E
authors.initials: DE
authors.lastname: Price
authors.forename: G D
authors.initials: GD
authors.lastname: Lang
authors.forename: J
authors.initials: J
authors.lastname: MacVicar
authors.forename: J R
authors.initials: JR
authors.lastname: Hearnshaw
mesh_terms: D001724:Birth Weight; D001786:Blood Glucose / Q000502:physiology*; D002585:Cesarean Section; D000013:Congenital Abnormalities; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005865:Gestational Age; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007003:Hypoglycemia / Q000151:congenital; D007231:Infant, Newborn; D007751:Labor, Induced; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011254:Pregnancy in Diabetics / Q000097:blood / Q000503:physiopathology*; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin