Klinefelter's syndrome and liver adenoma.
We describe the occurrence of a liver adenoma in a young patient with Klinefelter's syndrome, diagnosed by classic 47,XXY karyotype in all investigated cells and a sex hormone imbalance. To our knowledge, this is the first report of such an association, which might suggest a simple coincidence. However, a pathogenetic link between Klinefelter's syndrome and liver adenoma can be suggested in view of the following facts: Liver adenoma mostly affects women of child-bearing age using oral contraceptives. It is very rare in men, and affected men frequently have been treated with androgens. Both groups are characterized by a sex hormone imbalance. Also, the risk of breast cancer, another hormone-sensitive tumor, is greatly elevated in men with Klinefelter's syndrome, possibly due to sex hormone imbalance.
Beuers
U
U
Department of Internal Medicine II, Klinikum Grosshadern, University of Munich, Federal Republic of Germany.
Richter
W O
WO
Ritter
M M
MM
Wiebecke
B
B
Schwandt
P
P
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male