title: Butorphanol compared with fentanyl in general anaesthesia for ambulatory laparoscopy.
abstract: Butorphanol was compared with fentanyl as the narcotic component of general anaesthesia for ambulatory laparoscopic surgery. This double-blind, randomized study enrolled 60 healthy women who received equianalgesic doses of fentanyl 1 microgram.kg-1 (F, n = 30) or butorphanol 20 micrograms.kg-1 (B, n = 30) prior to induction of anaesthesia. Tracheal anaesthesia was maintained with nitrous oxide/oxygen, isoflurane, and succinylcholine by infusion. Intraoperatively, patients who received B demonstrated lower pulse rate before and after intubation (P less than 0.05, P less than 0.01) and lower diastolic blood pressure after intubation (P less than 0.01). Anesthesiologists judged the maintenance phase as satisfactory more often with B (P less than 0.05). Postoperatively, there were no differences in analgesic need. No major side-effects occurred in either group. Among minor side-effects, patients who received B reported postoperative sedation more often, 77% vs 37% (P less than 0.01), which occurred during the first 45 min of recovery (P less than 0.05). Discharge times were not different. On the first postoperative day, more subjects who received B were satisfied with their anaesthesia experience (P less than 0.05). Butorphanol 20 micrograms.kg-1 is an acceptable alternative analgesic in general anaesthesia for ambulatory laparoscopy.
authors.affiliation: Department of Anesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: B K
authors.initials: BK
authors.lastname: Philip
authors.forename: D A
authors.initials: DA
authors.lastname: Scott
authors.forename: D
authors.initials: D
authors.lastname: Freiberger
authors.forename: R R
authors.initials: RR
authors.lastname: Gibbs
authors.forename: C
authors.initials: C
authors.lastname: Hunt
authors.forename: E
authors.initials: E
authors.lastname: Murray
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D000768:Anesthesia, General; D002077:Butorphanol; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl; D006801:Humans; D010535:Laparoscopy
chemical_list: D002077:Butorphanol; D005283:Fentanyl