The effect of menadione epoxide on the experimental immune arthritis in the rabbit.
It was shown previously that the experimentally induced arthritis in the rabbit can be largely nullified by subsequent treatment with menadione (by gavage). It is now shown that menadione epoxide, as is produced in the vitamin K cycle, also exerts a beneficial effect histologically and biochemically. Such treatment decreased both the glucose 6-phosphate dehydrogenase and the 6-phosphogluconolactonase activities in the synovial lining cells of the challenged joints towards values found in the unchallenged joints; it had only equivocal effects on the 6-phosphogluconate dehydrogenase activity. The results indicated that the epoxide might be interfering primarily with the lactonase activity.
Pitsillides
A A
AA
Unit of Cellular Pharmacology and Toxicology, Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, UK.
Blake
S M
SM
Glynn
L E
LE
Frost
G T
GT
Bitensky
L
L
Chayen
J
J
D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D001831:Body Temperature / Q000187:drug effects; D002265:Carboxylic Ester Hydrolases / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D010734:Phosphogluconate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D014812:Vitamin K / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024483:Vitamin K 3 / Q000031:analogs & derivatives*
D014812:Vitamin K; C079335:menadione epoxide; D024483:Vitamin K 3; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D002265:Carboxylic Ester Hydrolases; C022363:6-phosphogluconolactonase