title: [Coronary vascular reserve in heart transplantation. Normalization after therapy for rejection].
abstract: Acute rejection is associated with severe impairment of coronary reserve in heart transplants. To evaluate the effects of rejection therapy, coronary reserve was assessed in 6 patients before and after treatment of an acute episode of rejection. Coronary reserve was significantly enhanced after rejection therapy (4.7 +/- 0.8, vs 2.3 +/- 0.5, P less than 0.001) and was not significantly different from that of transplanted patients without rejection (5.4 +/- 0.8). This study provides evidence that alterations of coronary reserve due to acute rejection are reversible after treatment of the rejection episode.
authors.affiliation: Physiologie et d'Explorations Fonctionnelles, CHU Xavier-Bichat, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Nitenberg
authors.forename: O
authors.initials: O
authors.lastname: Tavolaro
authors.forename: C
authors.initials: C
authors.lastname: Benvenuti
authors.forename: D
authors.initials: D
authors.lastname: Loisance
authors.forename: J M
authors.initials: JM
authors.lastname: Foult
authors.forename: L
authors.initials: L
authors.lastname: Hittinger
authors.forename: A
authors.initials: A
authors.lastname: Castaigne
authors.forename: J P
authors.initials: JP
authors.lastname: Cachera
authors.forename: P
authors.initials: P
authors.lastname: Vernant
mesh_terms: D000208:Acute Disease; D003327:Coronary Disease / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D006084:Graft Rejection / Q000187:drug effects*; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents
vernacular_title: Réserve vasculaire coronaire dans la transplantation cardiaque. Normalisation après traitement du rejet.