Effects of suramin on phagocytes in vitro.
In the therapeutically important range (100-200 micrograms/ml), suramin was found to increase the phagocytic activity of human monocytes (measured by the uptake of Saccharomyces cerevisiae and sensitized sheep red blood cells) in vitro. Suramin itself was a chemotactic signal for monocytes and increased the chemiluminescence of neutrophil granulocytes. Suramin seems to act via the ATP-binding P2 receptors of human phagocytes.
Sipka
S
S
3rd Department of Internal Medicine, University Medical School of Debrecen, Hungary.
Dankó
K
K
Nagy
P
P
Taskov
V
V
Dénes
L
L
Czirják
L
L
Szegedi
G
G
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004912:Erythrocytes; D006801:Humans; D008163:Luminescent Measurements; D009895:Opsonin Proteins; D010586:Phagocytes / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D011983:Receptors, Purinergic / Q000187:drug effects / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D012756:Sheep; D013498:Suramin / Q000494:pharmacology*; D015054:Zymosan / Q000494:pharmacology
D009895:Opsonin Proteins; D011983:Receptors, Purinergic; D013498:Suramin; D000255:Adenosine Triphosphate; D015054:Zymosan