title: Three-point versus two-point method for early individualization of aminoglycoside doses.
abstract: An approach using two serum concentrations following the initial dose of an aminoglycoside was retrospectively evaluated using the first and third samples from all three-point studies conducted by the pharmacokinetic consult service in 1988. The same Sawchuk and Zaske method was used for the three-point and two-point studies. Although the predicted peaks and troughs from the two-point study were statistically different from those of the three-point study, it is the authors' opinion that the root mean squared error of 0.38 mg/L (95% confidence interval [CI] 0.31-0.45) for the peaks and 0.09 mg/L (95% CI 0.06-0.11) for troughs is well within the limits of acceptable clinical error for gentamicin and tobramycin. Eliminating one-third of initial aminoglycoside concentrations could result in significant time and cost savings.
authors.affiliation: School of Pharmacy, Ferris State University, Big Rapids, MI 49307.
authors.forename: J P
authors.initials: JP
authors.lastname: Jameson
authors.forename: J A
authors.initials: JA
authors.lastname: Lewis
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008991:Monitoring, Physiologic; D011237:Predictive Value of Tests; D012189:Retrospective Studies
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents