title: Fulicin, a novel neuropeptide containing a D-amino acid residue isolated from the ganglia of Achatina fulica.
abstract: A novel pentapeptide containing a D-amino acid residue was purified from the central ganglia of the African giant snail Achatina fulica Ferussac, and it was named fulicin. The primary structure of the peptide was determined to be Phe-D-Asn-Glu-Phe-Val-NH2. Fulicin potentiated tetanic contraction of the penis retractor muscle of this snail at very low concentrations, and also showed modulatory actions on the activity of the buccal and ventricular muscles and the central ganglionic neurons.
authors.affiliation: Physiological Laboratory, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ohta
authors.forename: I
authors.initials: I
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Takao
authors.forename: Y
authors.initials: Y
authors.lastname: Shimonishi
authors.forename: Y
authors.initials: Y
authors.lastname: Yasuda-Kamatani
authors.forename: H
authors.initials: H
authors.lastname: Minakata
authors.forename: K
authors.initials: K
authors.lastname: Nomoto
authors.forename: Y
authors.initials: Y
authors.lastname: Muneoka
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005724:Ganglia / Q000737:chemistry*; D066298:In Vitro Techniques; D008297:Male; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009479:Neuropeptides / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology; D010413:Penis / Q000187:drug effects / Q000502:physiology; D012908:Snails
chemical_list: D009479:Neuropeptides; D009842:Oligopeptides; C070040:fulicin