title: Huperzine A--a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease.
abstract: Huperzine A, 9-amino-13-ethylidene-11-methyl-4-azatricyclo [7.3.1.0(3,8)]trideca-3(8),6,11-trien-5-one, C15H18N2O, Mr = 242.32, monoclinic, P2(1)/n, a = 8.8574 (6), b = 12.1833 (7), c = 12.4278 (7) A, beta = 99.956 (5) degrees, V = 1320.9 (1) A3, Z = 4, Dx = 1.22 g cm-3, lambda(Cu K alpha) = 1.54178 A, mu = 5.75 cm-1, F(000) = 520, T = 296 K, RF = 6.30% for 1402 reflections with Fo greater than or equal to 5 sigma(Fo) and 183 parameters. The pyridone ring is planar and the stereochemistry of the C(11)--C(12) double bond is E.
authors.affiliation: Department of Chemistry, Chevron Science Center, University of Pittsburgh, PA 15260.
authors.forename: S J
authors.initials: SJ
authors.lastname: Geib
authors.forename: W
authors.initials: W
authors.lastname: Tückmantel
authors.forename: A P
authors.initials: AP
authors.lastname: Kozikowski
mesh_terms: D000470:Alkaloids; D000544:Alzheimer Disease / Q000188:drug therapy*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D003460:Crystallization; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes; C050426:huperzine A