Ro15-4513 attenuates the consumption of ethanol in deprived rats.
This research investigated the effects of Ro15-4513 (Ro15), a partial inverse benzodiazepine agonist, on the drinking behavior of 23-1/2 hr fluid deprived rats. Water-deprived rats were maintained on a two-bottle regimen of a saccharin-ETOH solution along with tap water available for 30 min/day for several days. Following this acclimation period, animals were pretreated with either Ro15 (1.0, 2.5, and 5.0 mg/kg) or Tween-80 vehicle injections. Pretreatment with Ro15 at all doses tested resulted in a significant reduction of the saccharin-ETOH solution; however, Ro15 did not alter the rats' consumption of water. The effects of Ro15 on general fluid consumption was investigated in Experiment 2. Following acclimation to a two-bottle regimen of a saccharin-solution and tap water 30 min/day, naive animals were pretreated with Tween-80 vehicle or Ro15 injections. Ro15 failed to alter saccharin or water consumption. The results of this study support previous reports suggesting that Ro15 attenuates the oral consumption of ETOH; however, this effect does not appear to be due to a general suppression of fluid intake.
June
H L
HL
Department of Psychology, University of the District of Columbia, Washington, DC 20009.
Lummis
G H
GH
Colker
R E
RE
Moore
T O
TO
Lewis
M J
MJ
D000428:Alcohol Drinking / Q000523:psychology*; D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009042:Motivation; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000187:drug effects; D014868:Water Deprivation
D001386:Azides; D001569:Benzodiazepines; C042957:Ro 15-4513