Effects of cefonicid on platelet aggregation.
Beta-lactam antibiotics may interfere with platelet aggregation by inhibiting the binding of agonists of platelet aggregation, such as ADP and collagen, to specific receptor sites. The aim of this study was to evaluate in vitro the effects of cefonicid, a semi-synthetic cephalosporin, on platelet aggregation. Spontaneous platelet aggregation and platelet aggregation induced by ADP and collagen were assessed. Platelets from healthy subjects were incubated with cefonicid at final concentrations of 0.1 mg/ml, 1 mg/ml and 10 mg/ml (0.1 mg/ml is the concentration of cefonicid achieved in humans at therapeutic doses). When compared with saline, cefonicid at a concentration of 0.1 mg/ml had no effect on platelet aggregation, but at 1 mg/ml it inhibited ADP-induced aggregation and at 10 mg/ml it also inhibited aggregation induced by collagen. These findings suggest that therapeutic doses of cefonicid do not affect platelet aggregation.
Cazzola
M
M
36th Division of Pneumology and Respiratory Allergy, A. Cardarelli Hospital, Naples, Italy.
Santangelo
G
G
Paizis
G
G
Matera
C
C
Rossi
F
F
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D015790:Cefonicid / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009391:Nephelometry and Turbidimetry; D010974:Platelet Aggregation / Q000187:drug effects*
D000244:Adenosine Diphosphate; D015790:Cefonicid; D003094:Collagen