Proto-oncogene expression in cultured synovial fibroblasts of patients with rheumatoid arthritis.
Total RNA was isolated from cultured synovial fibroblasts of nine patients with rheumatoid arthritis and two controls (cruciate ligament ruptures). RNA was dot-blotted and hybridized with nine different, cloned cellular or viral oncogene probes. None of the proto-oncogenes showed a significant difference of expression in cultured fibroblasts from patients with rheumatoid arthritis when compared to the expression of control fibroblasts.
Anders
M
M
Abt. Biochemie, Robert Koch-Institut, Berlin, Germany.
Krohn
K
K
Kröger
H
H
Huser
H
H
Sparmann
M
M
Meissner
A
A
Gombert
W
W
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D015152:Blotting, Northern; D002455:Cell Division; D015342:DNA Probes; D005347:Fibroblasts / Q000378:metabolism; D015870:Gene Expression; D016259:Genes, myc; D011905:Genes, ras; D016391:Genes, src; D006801:Humans; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D013583:Synovial Membrane / Q000378:metabolism*
D015342:DNA Probes; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger