[Fixation of Indium111-labeled antifibrin monoclonal antibody on the vegetation in endocarditis: evaluation in a rabbit model].
The uptake of a 111In labelled antifibrin antibody was studied in left ventricle endocarditis on a rabbit model. The immunospecificity of the antibody for the cardiac vegetations is favorable, exhibiting an uptake at least 4 times that of blood, or myocardium. A planar scintigraphy of the opened left ventricle showed a radionuclide imaging of vegetations, according to anatomical lesions. The use of antifibrin monoclonal antibodies could prove helpful to improve the specificity of valvular lesions visualized by echocardiography, or to detect the small vegetations at the early stage of acute endocarditis.
Potel
G
G
Laboratoire d'Antibiologie Clinique et Expérimentale, CHU, Nantes.
Peltier
P
P
Kremer
M
M
Delajartre
A Y
AY
Baron
D
D
Chatal
J F
JF
Berger
H
H
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D004195:Disease Models, Animal; D004696:Endocarditis / Q000000981:diagnostic imaging* / Q000276:immunology; D005260:Female; D005337:Fibrin / Q000276:immunology*; D007205:Indium Radioisotopes; D011817:Rabbits; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D005337:Fibrin
Fixation d'un anticorps monoclonal anti-fibrine marqué à l'indium111 sur les végétations d'endocardite: évaluation sur le modèle d'endocardite du lapin.