title: A novel metabolite of strychnine, 22-hydroxystrychnine.
abstract: 1. An unknown metabolite of strychnine termed M-5 was isolated, from an incubation mixture using guinea pig liver microsomes, by repeated preparative t.l.c. 2. The structure of M-5 was shown to be 22-hydroxystrychnine by mass, n.m.r. and i.r. spectrometry. 3. 22-Hydroxystrychnine is a stable enol, a unique metabolite possessing a hydroxyl group on the double bond of the alicylic moiety.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tanimoto
authors.forename: T
authors.initials: T
authors.lastname: Ohkuma
authors.forename: K
authors.initials: K
authors.lastname: Oguri
authors.forename: H
authors.initials: H
authors.lastname: Yoshimura
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006168:Guinea Pigs; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D013331:Strychnine / Q000031:analogs & derivatives* / Q000378:metabolism*
chemical_list: C070090:22-hydroxystrychnine; D013331:Strychnine