[Comparative studies on immunogenicity of Chinese hamster ovary cell derived HB vaccine and plasma derived HB vaccine].
Chinese Hamster Ovary Cell derived HB vaccine (CDV) and plasma derived HB vaccine (PDV) were separately given to two groups of 131 and 112 medical stuff subjected, and both the anti-HBs responses were observed for 24 months from the time of first injection. The anti-HBs positive rate at the 7th month was 97% (mean geometric anti-HBs concentration 588 IU/L) in CDV group and 78% (83 IV/L) in PDV group, and the positive rate and mean titer of anti-HBs were always higher for 24 months in CDV group. The differences were remarkable between both the subjects aged over 40 years. The decreasing curves of the anti-HBs titer in the two groups were almost parallel; accordingly, the protective efficacy was estimated to be far longer in CDV. Also, the rate of non-responder was less lower (2.8%) in CDV group than that (15.2%) in PDV group. Above results show that CDV has a higher immunogenicity than PDV.
Yagura
M
M
Department of Gastroenterology, National Sanatorium Tokyo Hospital.
Kamitsukasa
H
H
Harada
H
H
Ohbayashi
A
A
D000328:Adult; D000368:Aged; D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010053:Ovary / Q000166:cytology*; D010949:Plasma / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
D006510:Hepatitis B Antibodies; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines