title: Amyloid beta-protein in cerebral amyloid angiopathy, senile plaques, and preamyloidotic lesions in subcortical arteriosclerotic encephalopathy (Binswanger disease).
abstract: Cerebral vascular amyloid deposits, senile plaques and neurofibrillary tangles have been found in subcortical arteriosclerotic encephalopathy (Binswanger disease). A mouse antiserum, prepared against a 43-amino acid synthetic peptide homologous to the amyloid beta-protein of Alzheimer disease (anti-SP43), revealed immunoreactive amyloid deposits in meningeal and intracortical blood vessels, senile plaques, intraneuronal amyloid and preamyloid in a neuropathologically confirmed case of Binswanger disease previously reported to have cerebral vascular amyloid deposits. These lesions contained sulfated glycosaminoglycans as determined by the Alcian blue/critical electrolyte concentration method. Similar findings were not observed in a case of Binswanger encephalopathy without cerebral amyloid deposits. Our study indicates that amyloidotic lesions in Binswanger encephalopathy with cerebral amyloid deposits contain amyloid beta-protein and sulfated glycosaminoglycans.
authors.affiliation: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
authors.forename: D C
authors.initials: DC
authors.lastname: Guiroy
authors.forename: A
authors.initials: A
authors.lastname: Bogucki
authors.forename: W
authors.initials: W
authors.lastname: Papierz
authors.forename: P P
authors.initials: PP
authors.lastname: Liberski
authors.forename: R
authors.initials: R
authors.lastname: Yanagihara
mesh_terms: D016229:Amyloid beta-Peptides / Q000032:analysis*; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry; D002536:Cerebral Arteries / Q000737:chemistry / Q000473:pathology; D015140:Dementia, Vascular / Q000378:metabolism* / Q000473:pathology; D006025:Glycosaminoglycans / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D016229:Amyloid beta-Peptides; D006025:Glycosaminoglycans