Augmented interleukin 6 production by rat thyrocytes (FRTL5): effect of interleukin 1 beta and thyroid-stimulating hormone.
This study shows that rat thyroid follicular (FRTL5) cells can produce interleukin 6 (IL-6) spontaneously and that IL-1 beta enhanced the production of IL-6 dose-dependently. In addition, 10 ng/mL of IL-1 beta in combination with 10 to 1,000 microU/mL of thyroid-stimulating hormone (TSH) synergistically enhanced IL-6 production. It is suggested that IL-6 released from thyroid follicular cells may be a costimulator of autoreactive B and T cells in autoimmune thyroid disease and may constitute another link between the immune and endocrine systems.
Iwamoto
M
M
Third Department of Internal Medicine, University of Yamanashi Medical School, Japan.
Sakihama
T
T
Kimura
N
N
Tasaka
K
K
Onaya
T
T
D000818:Animals; D002460:Cell Line; D004357:Drug Synergism; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology; D015850:Interleukin-6 / Q000096:biosynthesis*; D007700:Kinetics; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects / Q000276:immunology*; D013972:Thyrotropin / Q000008:administration & dosage / Q000494:pharmacology
D007375:Interleukin-1; D015850:Interleukin-6; D013972:Thyrotropin