title: Regression of carotid plaques during low density lipoprotein cholesterol elimination.
abstract: We performed serial prospective ultrasound examinations of four flat and 17 soft carotid plaques during an average of 17 months in seven patients with heterozygous hypercholesterolemia during heparin-induced extracorporeal low density lipoprotein elimination on precipitation from plasma. By means of a specially designed quantitative three-dimensional ultrasound analysis, significant plaque volume reduction could be evaluated in all subjects, along with a marked reduction of total and low density lipoprotein cholesterol and fibrinogen serum levels.
authors.affiliation: Department of Neurology, Heinrich-Heine University, Düsseldorf, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Hennerici
authors.forename: W
authors.initials: W
authors.lastname: Kleophas
authors.forename: F A
authors.initials: FA
authors.lastname: Gries
mesh_terms: D000328:Adult; D001161:Arteriosclerosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000188:drug therapy; D001783:Blood Flow Velocity; D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy; D008078:Cholesterol, LDL / Q000097:blood*; D005500:Follow-Up Studies; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011446:Prospective Studies; D014463:Ultrasonography
chemical_list: D008078:Cholesterol, LDL; D006493:Heparin