title: Does desflurane modify circulatory responses to stimulation in humans?
abstract: We asked if desflurane with or without nitrous oxide at 0.83, 1.24, and 1.66 MAC prevented cardiovascular responses to stimulation. We measured cardiac output, heart rate, systemic arterial blood pressure, central venous pressure, pulmonary arterial blood pressure, and systemic vascular resistance in six healthy male volunteers before (control) and at 0, 1, 2, 4, and 6 min after tetanic electrical stimulation (50, 100, and 200 Hz) of the ulnar nerve. At 0.83 and 1.24 MAC, cardiac output, mean systemic arterial blood pressure, heart rate, and pulmonary arterial blood pressure increased. Peak changes averaged 13%-20% and most frequently occurred 0-2 min after stimulation (P less than 0.05) with return to control values at 4-6 min (except for pulmonary arterial blood pressure). At 1.66 MAC, heart rate and systemic blood pressure responses were attenuated, but this level of anesthesia had equivocal effects on the cardiac output and pulmonary blood pressure responses. The addition of nitrous oxide attenuated the peak response of heart rate and cardiac output but not the peak response of mean systemic arterial blood pressure. In summary, 0.83 and 1.24 MAC desflurane did not abolish cardiovascular responses to stimulation, but 1.66 MAC attenuated the responses.
authors.affiliation: Department of Anesthesia, University of California, San Francisco 94143-0464.
authors.forename: N
authors.initials: N
authors.lastname: Yasuda
authors.forename: R B
authors.initials: RB
authors.lastname: Weiskopf
authors.forename: M K
authors.initials: MK
authors.lastname: Cahalan
authors.forename: P
authors.initials: P
authors.lastname: Ionescu
authors.forename: J E
authors.initials: JE
authors.lastname: Caldwell
authors.forename: E I
authors.initials: EI
authors.lastname: Eger
authors.forename: I J
authors.initials: IJ
authors.lastname: Rampil
authors.forename: S H
authors.initials: SH
authors.lastname: Lockhart
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000777:Anesthetics / Q000494:pharmacology*; D001775:Blood Circulation / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects*; D000077335:Desflurane; D004558:Electric Stimulation; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D009609:Nitrous Oxide / Q000494:pharmacology; D014459:Ulnar Nerve
chemical_list: D000777:Anesthetics; D000077335:Desflurane; D007530:Isoflurane; D009609:Nitrous Oxide