title: [Optimal pressure support ventilation as studied in a mathematical model].
abstract: To determine the optimal pressure support (PS) level in pressure support ventilations (PSV), we combined a mathematical model representing lung mechanics and alveolar gas exchange with a PS respirator model. As suggested by Fiastro et al. (1988), we defined the optimal PS level with regard to the work of breathing in such a way that the external inspiratory work of breathing equalled zero. We found that the optimal PS level determined as above resulted in the mean airway pressure calculated during an inspiratory phase being equal to zero (or a CPAP level). Thus we suggest that the optimal pressure support in terms of the work of breathing could be accomplished without a direct calculation of the work of breathing.
authors.affiliation: Division of Biomedical Systems Engineering, Faculty of Engineering, Hokkaido University.
authors.forename: E
authors.initials: E
authors.lastname: Takahashi
authors.forename: I
authors.initials: I
authors.lastname: Tateishi
mesh_terms: D000403:Airway Resistance; D003198:Computer Simulation; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation / Q000379:methods*; D008168:Lung / Q000503:physiopathology; D008176:Lung Volume Measurements; D011312:Pressure; D011659:Pulmonary Gas Exchange; D012123:Pulmonary Ventilation; D012120:Respiration Disorders / Q000503:physiopathology / Q000628:therapy