[Mechanism of antioxidant action of carnosine].
The comparative study of the antiradical activity of carnosine and vitamin C was carried out by the means of the evaluation of quenching of ESR signals of 2,2-diphenyl-1-picrylhydrazyl (DFPH) and semiquinone radical of alpha-tocopherol. It was shown that carnosine is not able to quench the ESR signals of the stable radical of DFPH and semiquinone radical of alpha-tocopherol. It permits to conclude that: a) carnosine does not interact directly with highly active free radicals; b) carnosine is unable to regenerate the radical of alpha-tocopherol to form the antiradical synergistic couple. The data obtained are consistent with the idea that there is a difference between on the antioxidant mechanism action of vitamin C and carnosine due to the difference in the antiradical activity of these compounds.
Gorbunov
N V
NV
Erin
A N
AN
D000975:Antioxidants; D015764:Bepridil / Q000031:analogs & derivatives / Q000494:pharmacology; D001713:Biphenyl Compounds; D001799:Blood Sedimentation; D002336:Carnosine / Q000494:pharmacology*; D005609:Free Radicals; D006801:Humans; D007202:Indicators and Reagents; D010851:Picrates; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D007202:Indicators and Reagents; D010851:Picrates; D014810:Vitamin E; D015764:Bepridil; D002336:Carnosine; C004931:1,1-diphenyl-2-picrylhydrazyl
Mekhanizm antioksidantnogo deĭstviia karnozina.