[The relationship between the aortic pulse wave velocity and osteoporosis in elderly women].
The relationship between arteriosclerosis and osteoporosis (OP) was assessed in 20 elderly women. The aortic pulse wave velocity (PWV) was used as the index of arteriosclerosis and bone mineral content (BM) of the vertebral body, which was measured by quantitative computed tomography, was used as an index of OP. PWV and BM showed a significant correlation with aging (PWV and age: r = 0.466, p less than 0.05, BM and age: r = -0.487, p less than 0.05). In the group in which the serum alkaline phosphatase (ALP) was higher than 180 IU/l (n = 11), there was a significant inverse correlation between PWV and BM (r = -0.728, p less than 0.02). On the other hand, there was no correlation between PWV and BM in the group in which ALP was lower than 180 IU/l (n = 9). These results suggest that in cases with OP and high levels of ALP, calcium (Ca) seems to be released from the bone system and transferred to the wall of the aorta. The mechanism and pathogenesis of this Ca transference is unknown and should be investigated.
Mori
H
H
Third Department of Internal Medicine, Nagasaki University School of Medicine.
Seto
S
S
Oku
Y
Y
Hashiba
K
K
Ochi
S
S
Seto
M
M
Mameya
G
G
D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D001011:Aorta / Q000503:physiopathology*; D001161:Arteriosclerosis / Q000150:complications / Q000503:physiopathology; D015519:Bone Density; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000503:physiopathology*; D011674:Pulse
D000469:Alkaline Phosphatase