Enhanced development of morphine tolerance in rats treated with 2-deoxy-D-galactose.
Rats treated subcutaneously for 6 days with morphine developed a weak tolerance which was characterized by a decrease in the analgesic action of the opioid. Under those experimental conditions a simultaneous intracerebroventricular application of 2-deoxy-D-galactose enhanced development of morphine tolerance, while other deoxy-sugars like 2-deoxy-D-glucose and 6-deoxy-D-galactose were ineffective. In contrast, no influence of 2-deoxy-D-galactose on a more enhanced morphine tolerance after a 11-day pretreatment with morphine was found. The results are discussed in the light of a rather specific interference of 2-deoxy-D-galactose with neuronal glycoprotein processing and related cellular mechanism underlying adaptive processes involved in the development of morphine tolerance.
Richter
P
P
Institute of Neurobiology and Brain Research, Magdeburg, Federal Republic of Germany.
Pohle
W
W
Grecksch
G
G
Smalla
K H
KH
Jork
R
R
Matthies
H
H
D000698:Analgesia; D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology; D004361:Drug Tolerance; D005643:Fucose / Q000494:pharmacology; D005690:Galactose / Q000031:analogs & derivatives* / Q000494:pharmacology; D006023:Glycoproteins / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D006023:Glycoproteins; D005643:Fucose; C019327:2-deoxy-lyxo-hexose; D009020:Morphine; D003847:Deoxyglucose; D005690:Galactose