Clinical evaluation of the effects of storage time and irradiation on transfused platelets.
Platelet concentrates stored for up to 5 days at room temperature or irradiated with 15 Gy immediately prior to transfusion were evaluated for their ability to increase the platelet count in thrombocytopenic patients. Platelets irradiated with a dose of 15 Gy immediately prior to transfusion achieved corrected increments (CI) at 1 and 20 h after transfusion no different from those achieved by non-irradiated platelets. Storage for 5 days reduced the mean 1-hour CI to 5.7 compared with a mean of 12.3 achieved by platelets transfused after only 1-day storage (p = 0.008). Similarly, the frequency of a repeat transfusion being indicated within 24 h increased with increasing storage time (p = 0.005).
Duguid
J K
JK
Mersey and North Wales Regional Transfusion Service, Royal Liverpool Hospital, UK.
Carr
R
R
Jenkins
J A
JA
Hutton
J L
JL
Lucas
G F
GF
Davies
J M
JM
D001792:Blood Platelets / Q000528:radiation effects; D001793:Blood Preservation; D001803:Blood Transfusion; D006801:Humans; D017713:Platelet Transfusion; D013997:Time Factors