[Analysis of the circadian rhythm of pain].
An electronic pulp tester was used to study the stimulus threshold in human teeth of 28 healthy volunteers for 1,5-4 days and the duration of local anaesthesia in 55 patients with caries. Rhythm analysis was performed with a non-linear fitting program on an IBM computer (PHARMFIT); in 21 out of the 28 volunteers significant daily rhythms in stimulus threshold could be detected. In the patients the maximum duration of local anaesthesia was after drug application at 2 p.m.
Lemmer
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Zentrum der Pharmakologie, Klinikum der J.W. Goethe-Universität, Frankfurt/Main.
D000293:Adolescent; D000328:Adult; D000766:Anesthesia, Dental; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D003731:Dental Caries / Q000503:physiopathology; D003782:Dental Pulp / Q000294:innervation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009619:Nociceptors / Q000187:drug effects / Q000503:physiopathology*; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D014098:Toothache / Q000503:physiopathology*
Analyse von zirkadianen Schmerzrhythmen.