[Experimental study on the accumulation of 125I-IMP in the cigarette-exposed lung].
In the experiment using guinea pigs, the accumulated portions of IMP after 125I-IMP microautoradiography were compared in a normal control group and a group exposed to cigarette smoke. In the smoke-exposed lung, the accumulation of silver grains were observed in the alveolar spaces and alveolar macrophages, as well as in the pulmonary capillaries and the alveolar epithelia. After the broncho-alveolar lavage (BAL), increases in alveolar macrophages, total counts of BAL fluid and counts of cell components were seen in the smoke-exposed lung. These results suggested that abnormal function of the pulmonary capillary or alveolar epithelium was wide spread in the smoke-exposed lung.
Kato
K
K
Department of Radiology, Iwate Medical University.
Takahashi
T
T
Yanagisawa
T
T
D000662:Amphetamines / Q000493:pharmacokinetics*; D000818:Animals; D001345:Autoradiography; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002452:Cell Count; D006168:Guinea Pigs; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008168:Lung / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D008297:Male; D012907:Smoking / Q000009:adverse effects*
D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine