Effect of advanced aging on ability of mice to cause regression of an immunogenic lymphoma in response to immunotherapy based on depletion of suppressor T cells.
This study shows that two therapeutic agents, anti-CD4 mAb and vinblastine, capable of causing T-cell-mediated regression of an established L5178Y lymphoma in 3-month-old mice, are incapable of causing regression of this tumor in 20- to 22-month-old mice. It is known that both agents are immunoaugmentative because of their ability to destroy tumor-induced CD4+ suppressor T cells preferentially. Therefore, the results indicate, that aged mice, unlike young mice, are not capable of generating therapeutic numbers of CD8+ effector T cells in the absence of suppressor cells.
Dunn
P L
PL
Trudeau Institute, Saranac Lake, NY 12983.
North
R J
RJ
D000375:Aging / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D015704:CD4 Antigens / Q000276:immunology; D007167:Immunotherapy; D007940:Leukemia L5178 / Q000276:immunology* / Q000628:therapy; D051379:Mice; D008811:Mice, Inbred DBA; D012074:Remission Induction; D013601:T-Lymphocytes / Q000502:physiology; D014747:Vinblastine / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D014747:Vinblastine