Urinary elimination of salsolinol enantiomers in alcoholics.
The analysis of the urine from 6 chronic alcoholics showed that (R)- and (S)-salsolinol were detectable in 4 subjects, the R enantiomer was only found in one and that both enantiomers were under the limit of detection in another one. 1,2-Dehydrosalsolinol was present in the urine of all of them. There was no correlation between the presence of alcohol in blood upon admission to the hospital and that of either salsolinol enantiomer in urine In a previous study (Strolin Benedetti et al., 1989 b), both salsolinol enantiomers were found in the urine of 3 out of 6 healthy subjects, possibly in relation with regular intake of alcoholic beverages. The content in (R)- and (S)-salsolinol was determined in the same 3 subjects after deprivation of alcohol for 24 h. Under these conditions, only (R)-salsolinol was detected in urine and this also after ingestion of 50 g of alcohol (500 ml Chianti). The possible involvement of the non-physiological enantiomer of salsolinol in alcohol addiction deserves further study.
Dostert
P
P
Farmitalia Carlo Erba, Research & Development, Erbamont Group, Milan, Italy.
Strolin Benedetti
M
M
Dordain
G
G
Vernay
D
D
D000328:Adult; D000437:Alcoholism / Q000652:urine*; D006801:Humans; D007546:Isoquinolines / Q000493:pharmacokinetics / Q000652:urine*; D008297:Male; D008875:Middle Aged
D007546:Isoquinolines; C036617:salsolinol