Characterization of sodium-selective optode membranes based on neutral ionophores and assay of sodium in plasma.
Plasticized poly(vinyl chloride) membranes that incorporate a highly lipophilic sodium-selective neutral ionophore (ETH 4120) and novel H(+)-selective chromo-ionophores, lipophilic isologs of Nile Blue, are used in the competitive binding of Na+ and H+ for a reversible, optical determination of sodium activities in buffered solutions at different selected pH values. These optode membranes are used to assay total sodium concentrations in pH-buffered human blood plasma.
Seiler
K
K
Swiss Federal Institute of Technology (ETH), Department of Organic Chemistry, Zürich, Switzerland.
Wang
K
K
Bakker
E
E
Morf
W E
WE
Rusterholz
B
B
Spichiger
U E
UE
Simon
W
W
D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007476:Ionophores / Q000737:chemistry*; D008567:Membranes, Artificial; D011143:Polyvinyl Chloride; D012964:Sodium / Q000097:blood*; D013379:Substrate Specificity
D007476:Ionophores; D008567:Membranes, Artificial; D011143:Polyvinyl Chloride; D012964:Sodium