title: Characterization of prednisone, prednisolone and their metabolites by gas chromatography-mass spectrometry.
abstract: Human urinary metabolites of the synthetic corticosteroids prednisone and prednisolone were detected in the course of gas chromatographic steroid profiling as methoxime-trimethylsilyl derivatives. Metabolites were provisionaly identified by combined gas chromatography-mass spectrometry. The major metabolites were 11-keto/11-hydroxy conversion products, 20-hydroxy and 4,5-dihydro analogues of the parent drugs. Cortisone, 6-hydroxy and fully saturated A-ring compounds were minor metabolites. Retention indices and mass spectral data are presented.
authors.affiliation: Anti-Doping Centre, Central Institute of Sport, Moscow, U.S.S.R.
authors.forename: G M
authors.initials: GM
authors.lastname: Rodchenkov
authors.forename: A N
authors.initials: AN
authors.lastname: Vedenin
authors.forename: V P
authors.initials: VP
authors.lastname: Uralets
authors.forename: V A
authors.initials: VA
authors.lastname: Semenov
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D011239:Prednisolone / Q000652:urine*; D011241:Prednisone / Q000652:urine*
chemical_list: D011239:Prednisolone; D011241:Prednisone