title: Suppressive effect of high energy shock waves on tumor cells.
abstract: Suppressive effect on tumor cells of high energy shock waves (HESW) has aroused the interest of physicians in recent years. We assessed experimentally the cytotoxic effects of HESW on tumor cells both in vitro and in vivo and determined whether a Chinese domestic lithotriptor is capable of generating effective HESW, which has the potential to break tumor cells, reduce cell viability, retard cell growth, delay doubling time, impair cell attachment and cell clonogenicity. In nude rats, HESW was able to delay tumor growth and reduce tumor size without evidence of metastasis. The nature of HESW in the induction of cell damage and its clinical application need to be further investigated.
authors.affiliation: Department of Urology, First Affiliated Hospital, Suzhou Medical College.
authors.forename: C L
authors.initials: CL
authors.lastname: Chen
authors.forename: Z H
authors.initials: ZH
authors.lastname: Guo
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: C Y
authors.initials: CY
authors.lastname: Yan
authors.forename: J X
authors.initials: JX
authors.lastname: Pu
authors.forename: Z X
authors.initials: ZX
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000628:therapy; D002455:Cell Division; D002470:Cell Survival; D009368:Neoplasm Transplantation; D051381:Rats; D011923:Rats, Nude; D014407:Tumor Cells, Cultured; D014464:Ultrasonic Therapy; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy