title: Neonatal gastrointestinal growth and function: are they regulated by composition of feeds?
abstract: The effects of natural suckling versus a cow's milk formula on gastrointestinal growth and mucosal function were measured in newborn guinea pigs during the first 8 days of postnatal life. Comparable growth was achieved between the two groups. Both feeds appeared to be a stimulus for the growth of the gastrointestinal tract and expression of disaccharidases, but not for mucosal growth. Formula feeding was associated with a diminished rate of lactase expression and an enhanced rate of maltase and sucrase expression suggesting that the effect of natural suckling is regulatory, acting to delay expression of an inherent ontogenic programme uncovered by formula feeding. These finding in the precocial guinea pig contrast with those in the altricial rat, and have implications for our understanding of the regulation of gastrointestinal development and effects of formula feeds, in other species, including man.
authors.affiliation: University of Cambridge, UK.
authors.forename: L T
authors.initials: LT
authors.lastname: Weaver
authors.forename: L
authors.initials: L
authors.lastname: Landymore-Lim
authors.forename: A
authors.initials: A
authors.lastname: Lucas
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002417:Cattle; D002432:Cecum / Q000254:growth & development; D004247:DNA / Q000378:metabolism; D004064:Digestive System / Q000254:growth & development*; D004068:Digestive System Physiological Phenomena; D004186:Disaccharidases / Q000378:metabolism; D006168:Guinea Pigs; D007420:Intestine, Large / Q000254:growth & development; D007421:Intestine, Small / Q000254:growth & development; D008892:Milk; D009092:Mucous Membrane / Q000254:growth & development / Q000378:metabolism; D009929:Organ Size; D011506:Proteins / Q000378:metabolism; D013270:Stomach / Q000254:growth & development
chemical_list: D011506:Proteins; D004247:DNA; D004186:Disaccharidases