Immunoregulatory effects of ovine trophoblastin protein (oTP): all five isoforms suppress PHA-induced lymphocyte proliferation.
The immunosuppressive properties of ovine trophoblastin protein (oTP) isoforms purified to homogeneity by DEAE HPLC have been studied within and across species barriers by in vitro assays. It has been demonstrated that not only the classical oTP 1, but in fact all 5 isoforms, are immunosuppressive in a PHA-induced proliferation assay, whilst being ineffective on IL-2 dependent CTL-L2 cell replication. The significance of these findings is discussed.
Fillion
C
C
U 262 INSERM, Maternité de Baudelocque, Paris, France.
Chaouat
G
G
Reinaud
P
P
Charpigny
J C
JC
Martal
J
J
D000818:Animals; D003470:Culture Media; D046508:Culture Techniques; D006041:Goats / Q000097:blood; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007370:Interferon Type I; D007376:Interleukin-2 / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011257:Pregnancy Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D012756:Sheep / Q000196:embryology; D016176:T-Lymphocyte Subsets / Q000187:drug effects*
D003470:Culture Media; D007166:Immunosuppressive Agents; D007370:Interferon Type I; D007376:Interleukin-2; D010835:Phytohemagglutinins; D011257:Pregnancy Proteins; C020947:interferon tau