Increased production of 15-hydroxyeicosatetraenoic acid by placentae from pregnancies complicated by pregnancy-induced hypertension.
Placentae from pregnancies complicated by pregnancy-induced hypertension (PIH) secrete significantly more 15-hydroxyeicosatetraenoic acid (15-HETE) than gestation-matched controls. 15-HETE and its hydroperoxy precursor can inhibit prostacyclin biosynthesis and may thus contribute to the pathological sequelae of PIH.
Mitchell
M D
MD
Department of Obstetrics and Gynecology, University of Utah Medical Center, Salt Lake City 84132.
Koenig
J M
JM
D011464:Epoprostenol / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis*; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy
D006893:Hydroxyeicosatetraenoic Acids; C025984:15-hydroxy-5,8,11,13-eicosatetraenoic acid; D011464:Epoprostenol