title: [Analgesia using oral administration of tilidine naloxone for extracorporeal shockwave lithotripsy. A double blind study].
abstract: Reduction in pain perception during ESWL due to a technical modification of the lithotriptor was expected and prompted a reassessment of anaesthesia techniques for ESWL. In this study the need for analgesic treatment had to be investigated. After satisfactory preliminary results in a previous pilot study, the value of the oral combination of the anti-anxiety drug dipotassium clorazepate on the evening before ESWL together with the analgesic tilidine-naloxone before treatment was tested in a randomised double-blind study in 120 patients. In case of intolerable pain during the treatment all patients were free to ask for additional intravenous analgesic medication (fentanyl). During ESWL, 28.3% of the tilidine-N group patients and 6.7% of the placebo group were pain-free, whereas intolerable pain was reported by 30% of the tilidine-N group and 56.7% of the placebo group. Therefore, 70% of the tilidine-N group patients were treated without any additional analgesic or sedative medication. The good experience with this oral anaesthesia approach, the lack of significant side effects and a good acceptance by the patients warrant further recommendation of this technique.
authors.affiliation: Klinik für Anästhesiologie und operative Intensivmedizin, Ruhr-Universität Bochum.
authors.forename: U
authors.initials: U
authors.lastname: Hankemeier
authors.forename: D
authors.initials: D
authors.lastname: Herberhold
authors.forename: J
authors.initials: J
authors.lastname: Graff
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008096:Lithotripsy; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000008:administration & dosage*; D013993:Tilidine / Q000008:administration & dosage*
chemical_list: D000700:Analgesics; D004338:Drug Combinations; D009270:Naloxone; D013993:Tilidine
vernacular_title: Analgesie mit oraler Gabe von Tilidin-Naloxon zur extrakorporalen Stosswellenlithotripsie. Eine Doppelblindstudie.