Mechanisms of the angiotensin II effects on exploratory behavior of rats in open field. III. Modulatory role of GABA.
The effects of the octapeptide angiotensin II (AT II) and its interactions with GABA (gamma-aminobutyric acid) on the exploratory behavior of male rats in open field were studied. AT II (0.1 and 0.5 microgram i.c.v.) increased the open field behavior, mainly ambulation and rearing. GABA (100 micrograms i.c.v.) significantly reduced the effects of AT II. This influence of GABA was potentiated by subconvulsive doses of bicuculline. Our results demonstrate that the GABAergic system exerts an inhibitory control on pathways mediating the stimulatory effects of AT II on exploratory behavior in open field. The data also suggest close interactions between GABA AT II receptors.
Georgiev
V
V
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
Getova
D
D
Opitz
M
M
D000804:Angiotensin II / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001640:Bicuculline / Q000494:pharmacology; D004357:Drug Synergism; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000804:Angiotensin II; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline