title: The enhanced production of placental interleukin-1 during labor and intrauterine infection.
abstract: The purpose of this study was to determine the effect of labor and chorioamnionitis in interleukin-1 production by human placenta. We studied the activity of the placenta to produce interleukin-1 with an enzyme immunoassay by culturing tissue blocks. The placental tissue obtained after labor produced a larger amount of interleukin-1 than placental tissue obtained before labor. All the placental tissues produced more interleukin-1 beta than interleukin-1 alpha. The placentas with labor and chorioamnionitis produced about seventeenfold more interleukin-1 than placentas with labor only. We immunohistochemically identified interleukin-1--producing cells in the placenta and found that syncytiotrophoblasts produced both interleukin-1 alpha and interleukin-1 beta, while Hofbauer cells produced only interleukin-1 beta. In vitro analysis of the trophoblast activities to produce interleukin-1 revealed that microbial byproducts enhanced interleukin-1 production, possibly inducing accumulation of interleukin-1 receptor-positive cells at the sites of inflammation. In addition to stimulation of prostaglandin biosynthesis and labor, the placental interleukin-1 may act as an inflammatory mediator, leading to systemic and local changes at fetomaternal interface and activating fetomaternal immune systems against intrauterine infection.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Taniguchi
authors.forename: N
authors.initials: N
authors.lastname: Matsuzaki
authors.forename: T
authors.initials: T
authors.lastname: Kameda
authors.forename: K
authors.initials: K
authors.lastname: Shimoya
authors.forename: T
authors.initials: T
authors.lastname: Jo
authors.forename: F
authors.initials: F
authors.lastname: Saji
authors.forename: O
authors.initials: O
authors.lastname: Tanizawa
mesh_terms: D002821:Chorioamnionitis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000096:biosynthesis*; D007743:Labor, Obstetric; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D007375:Interleukin-1