DNA ploidy and cell kinetic measurements as predictors of recurrence and survival in stages B2 and C colorectal adenocarcinoma.
DNA content and cell proliferation were measured by flow cytometry on paraffin-embedded Stage B2 or C colorectal adenocarcinomas from 694 patients enrolled in adjuvant trials conducted by the North Central Cancer Treatment Group. Patients with diploid tumors had a higher survival rate than those with nondiploid tumors (P less than 0.001). The proliferation index (the sum of the percent of cells in S-phase plus those in G2M phase) was also a strong prognostic factor (P less than 0.001). The ploidy and proliferation data were combined, and the patients in the favorable group (diploid and low proliferative index) had a 5-year survival of 74% compared with 54% for the unfavorable group (high proliferative index or nondiploid, P less than 0.001). This grouping was prognostic for survival in B2 (P less than 0.001), C (P = 0.013), colon (P less than 0.001), and rectal (P = 0.026) patient subsets. This study indicates that cell kinetic parameters are important and independent prognostic factors for Stages B2 and C colorectal cancer.
Witzig
T E
TE
Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Loprinzi
C L
CL
Gonchoroff
N J
NJ
Reiman
H M
HM
Cha
S S
SS
Wieand
H S
HS
Katzmann
J A
JA
Paulsen
J K
JK
Moertel
C G
CG
D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality* / Q000473:pathology*; D002455:Cell Division; D015179:Colorectal Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011003:Ploidies; D011379:Prognosis; D012008:Recurrence; D016019:Survival Analysis
D004273:DNA, Neoplasm