The effect of omeprazole-induced hypergastrinemia on the oxyntic mucosa of mastomys.
Mastomys is a rodent with a high incidence of spontaneous carcinoids in the acid-producing part of the stomach. The present study was conducted to examine whether hypergastrinemia could promote tumor formation in this species. Mastomys, 4 months of age, were treated for 5 months with omeprazole subcutaneously, 100 mumol/kg body weight daily, and compared with mastomys given the vehicle only. The plasma gastrin concentration and the number of antral gastrin cells were increased in the omeprazole-treated group. The hypergastrinemia was associated with elevated histidine decarboxylase activity and histamine content in the oxyntic mucosa and with a trophic effect on the oxyntic mucosa and the enterochromaffin-like cells. However, no carcinoid tumors were observed, possibly because the strain of mastomys studied does not produce carcinoids spontaneously.
Brenna
E
E
Institute of Cancer Research, University Hospital, Trondheim, Norway.
Håkanson
R
R
Sundler
F
F
Sandvik
A K
AK
Waldum
H L
HL
D000818:Animals; D002276:Carcinoid Tumor / Q000209:etiology; D004759:Enterochromaffin Cells; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry / Q000166:cytology*; D005755:Gastrins / Q000097:blood*; D006632:Histamine / Q000032:analysis / Q000097:blood; D006640:Histidine Decarboxylase / Q000032:analysis; D007279:Injections, Subcutaneous; D008297:Male; D009115:Muridae; D009853:Omeprazole / Q000008:administration & dosage; D011863:Radioimmunoassay; D013274:Stomach Neoplasms / Q000209:etiology; D013997:Time Factors
D005755:Gastrins; D006632:Histamine; D006640:Histidine Decarboxylase; D009853:Omeprazole