title: [Tuberculosis of the larynx, oral cavity and pharynx].
abstract: A 44-year-old man, a heavy smoker over many years, complained of hoarseness for 8 weeks with weight loss and dysphagia. Malignant tumour of the pharynx was suspected. Examination revealed a swelling of the right upper lip, tumorous changes in the right buccal mucosa, about 6 x 6 cm in size, as well as enlargement of the cervical lymph-nodes. Microlaryngoscopy revealed a three-level tumour of the entire side of the right larynx. Histological examination of biopsies of the right false and true vocal cords as well as the buccal mucosa demonstrated numerous, partly caseous epithelioid granulomas with Langhans giant cells. Ziehl-Neelsen staining showed acid-fast rods. Combined tuberculostatic treatment with isoniazid, rifampicin, ethambutol and pyrazinamide achieved regression of all signs and symptoms within two months. This case emphasizes the need for including laryngeal tuberculosis in the differential diagnosis of seemingly malignant laryngeal tumours.
authors.affiliation: Abteilung Innere Medizin mit Schwerpunkt Infektionskrankheiten, Freien Universität Berlin.
authors.forename: T
authors.initials: T
authors.lastname: Held
authors.forename: W
authors.initials: W
authors.lastname: Rössler
authors.forename: A
authors.initials: A
authors.lastname: Reichelt
authors.forename: M
authors.initials: M
authors.lastname: Mielke
authors.forename: M
authors.initials: M
authors.lastname: Alexander
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004724:Endoscopy; D004977:Ethambutol / Q000008:administration & dosage; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage; D008297:Male; D010608:Pharyngeal Diseases / Q000175:diagnosis / Q000188:drug therapy; D010610:Pharyngeal Neoplasms / Q000175:diagnosis; D011718:Pyrazinamide / Q000008:administration & dosage; D012293:Rifampin / Q000008:administration & dosage; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy; D014387:Tuberculosis, Laryngeal / Q000175:diagnosis / Q000188:drug therapy; D014393:Tuberculosis, Oral / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D011718:Pyrazinamide; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin
vernacular_title: Tuberkulose von Kehlkopf, Mundhöhle und Rachen.