title: [Immune competence of human tissue lymphocytes in contact with loosened hip joint prostheses. On the topic of cellular or humoral rejection reaction as the mechanism of loosening].
abstract: In several investigations rejections were accused of being a possible cause for the loosening of hip endoprostheses. Using immunocytochemical techniques we studied the number and type of lymphocytes in the tissue adjacent to loosened hip endoprostheses. Tissue samples were taken from 18 patients being reoperated for a loosened endoprostheses. Impressive lymphocyte infiltrates were found in 4 of 18 patients (22%). These infiltrates only consisted of T-cells. In the other samples only few lymphocytes were detected belonging to T- and B-lymphocyte population, respectively. In our patients T-cell mediated rejections were of minor importance for the loosening of total hip replacement. B-cell accumulations were detected in none of the samples.
authors.affiliation: Orthopädische Klinik, Medizinischen Fakultät der RWTH Aachen.
authors.forename: K M
authors.initials: KM
authors.lastname: Peters
authors.forename: F
authors.initials: F
authors.lastname: Löer
authors.forename: F
authors.initials: F
authors.lastname: Hofstädter
authors.forename: H R
authors.initials: HR
authors.lastname: Casser
mesh_terms: D000368:Aged; D000917:Antibody Formation / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D005549:Foreign-Body Reaction / Q000276:immunology*; D006622:Hip Prosthesis; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D011183:Postoperative Complications / Q000276:immunology*; D011475:Prosthesis Failure; D013601:T-Lymphocytes / Q000276:immunology*
vernacular_title: Immunkompetenz menschlicher Lymphocyten im Kontaktgewebe gelockerter Hüftgelenkendoprothesen. Zur Frage der cellulären oder humoralen Abstossungsreaktionen als Mechanismus der Auslockerung.