title: Angiotensin II stimulates angiogenesis in the chorio-allantoic membrane of the chick embryo.
abstract: Angiotensin II was applied daily in doses of 67 or 670 ng to a section of the chick embryo chorio-allantoic membrane from day 7 to day 14 after fertilization of the eggs. During this one-week period, it caused a significant, dose-dependent increase in the vascular density index. The increase obtained with 670 ng daily was comparable to that after daily administration of 1.7 micrograms adenosine, a known stimulator of angiogenesis. The data suggest a possible role for angiotensin II as a mediator of vascular growth.
authors.affiliation: Department of Pharmacology, University of Limburg, Maastrict, The Netherlands.
authors.forename: F A
authors.initials: FA
authors.lastname: Le Noble
authors.forename: J W
authors.initials: JW
authors.lastname: Hekking
authors.forename: H W
authors.initials: HW
authors.lastname: Van Straaten
authors.forename: D W
authors.initials: DW
authors.lastname: Slaaf
authors.forename: H A
authors.initials: HA
authors.lastname: Struyker Boudier
mesh_terms: D000481:Allantoin; D000804:Angiotensin II / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000254:growth & development*; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply / Q000187:drug effects
chemical_list: D000804:Angiotensin II; D000481:Allantoin