title: Warfarin skin necrosis: recurrence in the absence of anticoagulant therapy.
abstract: Skin necrosis is a well-known yet rare complication of oral anticoagulant therapy. We report the unusual recurrence of lesions typical of warfarin skin necrosis in the absence of anticoagulant therapy. A 59-year-old woman developed skin necrosis while receiving prophylactic warfarin following the detection of a large left ventricular thrombus. The warfarin was discontinued and the lesions improved. One month later new areas of skin necrosis developed although the patient had received no further warfarin. Progressive congestive heart failure, poor nutrition, and prolonged oral antibiotic therapy preceded the recurrence. Vitamin K deficiency was present on admission. The potential role of vitamin K-dependent coagulation factors in the pathogenesis of anticoagulant-associated skin necrosis is discussed.
authors.affiliation: Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville.
authors.forename: J E
authors.initials: JE
authors.lastname: Humphries
authors.forename: J H
authors.initials: JH
authors.lastname: Gardner
authors.forename: J E
authors.initials: JE
authors.lastname: Connelly
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D012871:Skin Diseases / Q000139:chemically induced* / Q000209:etiology; D014813:Vitamin K Deficiency / Q000150:complications; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D014859:Warfarin