[Significance of morphofunctional assessment of tissue basophil reactions in prognostication of harmful effects of chemical substances].
The article contains a comparative analysis of experimental data on the assessment of the general toxicological, gonadotrophic effects and morphofunctional reactions of tissue basophils under the influence of 4-bromine-o-xylene, carbon disulfide and pyracryl. Established was the gonadotrophic action of pyracryl against the growing activity of tissue basophils manifested through increased infiltration and high-level degranulation in female rats' reproductive organs. Demonstrated was that, under the influence of low-intensity chemical factors, tissue basophils morphofunctional reactions were those of organ-related nature. The quantitative assessment of tissue basophils was proposed as an informative model for studies of selective (gonadotrophic) actions of low-intensity chemical substances.
Iaglov
V V
VV
Sheina
N I
NI
Fesenko
M A
MA
D000818:Animals; D002246:Carbon Disulfide / Q000009:adverse effects*; D005260:Female; D008407:Mast Cells / Q000187:drug effects*; D010053:Ovary / Q000187:drug effects; D011109:Polymethacrylic Acids / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014992:Xylenes / Q000009:adverse effects*
D011109:Polymethacrylic Acids; D014992:Xylenes; C060247:4-bromo-1,2-xylene; C038799:pyracryl; D002246:Carbon Disulfide
Znachenie morfofunktsional'noĭ otsenki reaktsii tkanevykh bazofilov dlia prognozirovaniia vrednogo deĭstviia khimicheskikh veshchestv.