[Effectiveness of acylated thrombolytic agents in lysis of blood plasma clots from humans and various animals].
Kinetics of lysis of fibrin clots from the human, guinea pig, rat and rabbit blood plasma by two active-site-acylated derivatives of the activator plasmin-streptokinase complex with different reaction rate constants has been studied in vitro. It is found that lysis of blood plasma clots in guinea pig is most similar to that of man. Acyl activator dose being increased, the lysis of a plasma clot in guinea pig is accelerated. Two acyl activators exhibit higher fibrinolytic-efficiency as compared to a free activator. Experiments carried out in vivo on guinea pigs with thrombosis show that acyl activators, in contrast to nonmodified plasmin-streptokinase complex induce the less system activation of fibrinolysis and the less fibrinogenolysis.
Aĭsina
R B
RB
Bashkov
G V
GV
Eremeev
N L
NL
Popova
G Iu
GIu
Kazanskaia
N F
NF
D000215:Acylation; D000818:Animals; D016255:Anistreplase / Q000378:metabolism*; D001665:Binding Sites; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D006801:Humans; D007700:Kinetics; D011817:Rabbits; D051381:Rats
D005343:Fibrinolytic Agents; D016255:Anistreplase
Effektivnost' atilirovannykh tromboliticheskikh agentov v lizise sgustkov iz plazmy krovi cheloveka i zhivotnykh razlichnykh vidov.