title: Recurrent respiratory papillomatosis: progression to invasion and malignancy.
abstract: Recurrent respiratory papillomatosis is the most common benign tumor of the larynx in children. The disease often runs a protracted course necessitating multiple endolaryngeal procedures. Rarely, these papillomata become invasive and/or undergo malignant degeneration. A case report of malignant degeneration and widespread invasion in long-standing laryngeal papillomatosis and a review of the relevant literature are presented.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO 63110.
authors.forename: B
authors.initials: B
authors.lastname: Gaylis
authors.forename: R E
authors.initials: RE
authors.lastname: Hayden
mesh_terms: D000328:Adult; D002291:Carcinoma, Papillary; D002294:Carcinoma, Squamous Cell; D002471:Cell Transformation, Neoplastic; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary; D010212:Papilloma / Q000473:pathology