title: Vitamin D metabolism in pre-operative extrahepatic biliary atresia.
abstract: In order to clarify the pathogenesis of rickets in preoperative patients with extrahepatic biliary atresia, we evaluated baseline serum 25-OHD and 1,25(OH)2D levels and correlated serum 25-OHD levels with increase in age and season of birth in 16 preoperative patients. Further, parenteral vitamin D2 tolerance tests were performed in 5 cases. Serum 25-OHD and 1,25(OH)2D levels were significantly lower than those in 15 normal controls. There was a negative correlation between the serum 25-OHD levels and increase in age. The patients born during the winter had lower serum 25-OHD concentrations than those born in summer. The mean value of increased 25-OHD levels after the parenteral vitamin D2 tolerance tests did not differ from that of 6 controls. Since there was no impairment of vitamin D 25-hydroxylation, the reduction in serum 25-OHD may therefore be mainly due to disturbed intestinal vitamin D absorption. It was also concluded that season of birth and increase in age are pathogenic factors in the etiology of rickets in preoperative patients with extrahepatic biliary atresia.
authors.affiliation: Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tokita
authors.forename: H
authors.initials: H
authors.lastname: Nittono
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Maruyama
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Obinata
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Yabuta
authors.forename: T
authors.initials: T
authors.lastname: Miyano
mesh_terms: D001656:Biliary Atresia / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007408:Intestinal Absorption; D008297:Male; D011300:Preoperative Care; D012279:Rickets / Q000209:etiology*; D012621:Seasons; D014807:Vitamin D / Q000378:metabolism*
chemical_list: D014807:Vitamin D; D002117:Calcitriol; D002112:Calcifediol