Gastritis associated with infection by Helicobacter pylori in humans: geographical differences.
Previous studies have indicated that infection rates of Helicobacter pylori are influenced by geographical factors. The present studies evaluate the characteristics of gastritis, associated with infection by H. pyrlori, and demonstrate relationships between different geographical locations and the extent of inflammatory cell accumulation in the gastric mucosa. Gastric biopsy specimens were obtained from patients infected with H. pylori at three clinical sites (two from North America and one from South America). Gastric inflammation was evaluated by quantitative histomorphometric techniques. Patients from South America had a more severe gastritis than did those from North America. Additionally, in South American patients the neutrophil was the predominant inflammatory cell type in the gastric mucosa. In contrast, the lymphocyte was the primary cell composing the mucosal infiltrate of infected North American subjects. Eosinophil infiltration into the mucosa correlated with the extent of mucosal atrophy; however, there were no differences between the North and South American patient populations in the extent of mucosal atrophy present in the specimens. We conclude that the characteristics (severity and cell type) of gastritis associated with infection by H. pylori are influenced by geographical factors that may be similar to those that modify infection rates for different geographical locations.
Bertram
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TA
Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239-8707.
Murray
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PD
Morgan
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DR
Jerdak
G
G
Yang
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P
Czinn
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S
D000328:Adult; D000368:Aged; D005757:Gastritis, Atrophic / Q000453:epidemiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008875:Middle Aged; D009656:North America / Q000453:epidemiology; D012044:Regression Analysis; D012923:Social Class; D013020:South America / Q000453:epidemiology