title: Diabetes insipidus secondary to Wegener's granulomatosis: report and review of the literature.
abstract: We describe a 51-year-old woman with Wegener's granulomatosis who developed diabetes insipidus 7 months after the onset of her granulomatous disease and despite apparently good clinical response to prednisone and trimethoprim-sulphametoxazole treatment. A brain computerized tomographic scan taken soon after the onset of polyuria disclosed an enlarged pituitary gland that completely returned to its normal size after 5 months of cyclophosphamide therapy. We review 6 other published cases of diabetes insipidus secondary to Wegener's granulomatosis and discuss the potential pathogenetic mechanisms of this rare combination.
authors.affiliation: Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Mexico City, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Rosete
authors.forename: A R
authors.initials: AR
authors.lastname: Cabral
authors.forename: A
authors.initials: A
authors.lastname: Kraus
authors.forename: D
authors.initials: D
authors.lastname: Alarcón-Segovia
mesh_terms: D003919:Diabetes Insipidus / Q000209:etiology* / Q000473:pathology; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008875:Middle Aged