title: Closed loop blood pressure control for cerebral perfusion studies.
abstract: A method is presented which maintains mean arterial blood pressure at predetermined values during cerebrovascular occlusion studies in a rat model. The system consists of a pressure measurement apparatus, a pump capable of infusing and withdrawing fluids, and a personal computer to control the infusion and withdrawal rate. An evaluation of the system is presented, and potential advantages and difficulties are discussed.
authors.affiliation: Regional Medical Physics Department, Newcastle General Hospital, UK.
authors.forename: I R
authors.initials: IR
authors.lastname: Chambers
authors.forename: R D
authors.initials: RD
authors.lastname: Strachan
authors.forename: P J
authors.initials: PJ
authors.lastname: Kane
authors.forename: A
authors.initials: A
authors.lastname: Clark
authors.forename: A D
authors.initials: AD
authors.lastname: Mendelow
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000503:physiopathology; D001810:Blood Volume / Q000502:physiology; D002539:Cerebral Arterial Diseases / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D007023:Hypotension, Controlled / Q000379:methods*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains