Male lupus: prevalence of IgA deficiency, 7S IgM and abnormalities of reticuloendothelial system Fc-receptor function.
Serological studies conducted on sera from a group of 31 male SLE patients revealed a 32% prevalence of 7S IgM and a 9.7% prevalence of IgA deficiency. Previous reports using similar methods indicated a higher (43-50%) prevalence of 7S IgM than was found in studies involving predominantly females with SLE (15-18%), and an overall prevalence of IgA deficiency ranging from 0.95% to 4.6%. Males resembled females in the prevalence of Fc-receptor specific reticuloendothelial system dysfunction, correlating with levels of circulating immune complex-like material and disease activity.
Kaufman
L D
LD
Department of Medicine, State University of New York, Stony Brook 11794-8161.
Heinicke
M H
MH
Hamburger
M
M
Gorevic
P D
PD
D000974:Antibodies, Antinuclear / Q000032:analysis / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000097:blood; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D012157:Mononuclear Phagocyte System / Q000502:physiology / Q000648:ultrastructure*; D015995:Prevalence; D011961:Receptors, Fc / Q000502:physiology*; D012727:Sex Characteristics
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D011961:Receptors, Fc