title: Evaluation of microbial metabolites for trypanocidal activity: significance of biochemical and biological parameters in the mouse model of trypanosomiasis.
abstract: Trypanosomiasis is a parasitic disease, prevailing in both humans and animals, caused by a single-cell parasite, Trypanosoma spp. Three microbial metabolites, namely antiamoebin, F-857 and 6-MFA, were evaluated for trypanocidal activity by using a mouse model of trypanosomiasis, which is caused by T. evansi. The significance of the biological and biochemical parameters with respect to physio-pathology of trypanosomiasis and their implications in the evaluation of new trypanocidal compounds were discussed.
authors.affiliation: Laboratory of Parasitology and Immunodiagnostics, Research Center, Hindustan Antibiotics Ltd, Pune, India.
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: J N
authors.initials: JN
authors.lastname: Dhuley
authors.forename: S R
authors.initials: SR
authors.lastname: Naik
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D004195:Disease Models, Animal; D005656:Fungal Proteins / Q000627:therapeutic use*; D051379:Mice; D054848:Peptaibols; D010455:Peptides; D010456:Peptides, Cyclic / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014352:Trypanosomiasis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D005656:Fungal Proteins; D054848:Peptaibols; D010455:Peptides; D010456:Peptides, Cyclic; D014344:Trypanocidal Agents; C006596:antiamoebin; C008524:MFA 6 extract, Aspergillus ochraceus