[Pulsed Doppler echocardiography assessment of acute hemodynamic effects of nifedipine on pulmonary hypertension in chronic obstructive lung disease].
To observe acute hemodynamic effects of pulmonary hypertension in chronic obstructive lung disease by nifedipine, we studied 16 patients with pulsed doppler ultrasound. Pulsed doppler ultrasonogram was employed to measure hemodynamic parameters before and 45 minutes after nifedipine 20 mg (give po) in 16 patients. Results indicate that PAMP decreased significantly (P less than 0.01) from 5.5 +/- 1.6 to 4.0 +/- 1.5 kPa. We conclude that nifedipine reduces pulmonary artery pressure, at least acutely, in patients with hypoxic pulmonary hypertension.
Yuan
H
H
Department of Internal Medicine, First Affiliated Hospital of Human Medical University.
D000286:Administration, Sublingual; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D015150:Echocardiography, Doppler; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D008173:Lung Diseases, Obstructive / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use*; D011651:Pulmonary Artery / Q000503:physiopathology; D016278:Ventricular Function, Right / Q000187:drug effects
D009543:Nifedipine