[Annexins--a new family of Ca(2+)-binding proteins].
Annexins, the Ca(2+)- and phospholipid-binding proteins, are able to induce Ca(2+)-dependent aggregation of biomembranes. All the representatives of this family contain four or eight tandem repeats, 60-80 amino acids each. All these repeats include a highly conservative 17-member amino acid consensus sequence (an endonexin fold). The central domain comprises all these repeats and contains, in addition, the site(s) with a binding affinity for Ca2+ and phospholipids. Annexins are devoid of the classical "EF-hand" Ca(2+)-binding domain and can therefore be assigned to a new family of Ca(2+)-binding proteins.
Mel'gunov
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D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D008670:Metals / Q000378:metabolism; D008969:Molecular Sequence Data; D010743:Phospholipids / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid
D002135:Calcium-Binding Proteins; D008670:Metals; D010743:Phospholipids; D002118:Calcium
Anneksiny--novoe semeĭstvo Ca(2+)-sviazyvaiushchikh belkov.