[Reciprocal modulating effect of serotonin and dopamine on neurons of rat spinal ganglia].
It was found in experiments on isolated dorsal root ganglion neurons of rats that dopamine (10(-8)-10(-6) Mol/l) potentiated depolarizing neuronal responses evoked by injection of 5-hydroxytryptamine from micropipette. Similar concentrations of 5-hydroxytryptamine (10(-8)-10(-6) Mol/l) potentiated neuronal depolarizing responses evoked by dopamine. Potentiating action of monoamines on combined neuronal responses depended on concentration and was inhibited by antagonists of dopamine (haloperidol) and 5-hydroxytryptamine (deseril) receptors. This effect of monoamines had postsynaptic nature and was bound with an increase of Ca2+ and cAMP intracellular concentrations.
Abramets
I I
II
Samoĭlovich
I M
IM
D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D004357:Drug Synergism; D005727:Ganglia, Spinal / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D066298:In Vitro Techniques; D008784:Methysergide / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D006220:Haloperidol; D004298:Dopamine; D008784:Methysergide
Vzaimnoe moduliruiushchee vliianie serotonina i dofamina pri ikh vozdeĭstvii na neĭrony spinal'nykh gangliev krys.