How osteoblasts become osteocytes: a decreasing matrix forming process.
Osteocyte matrix inclusion process was studied in an in vitro woven bone nodule formation model where a large number of osteocytes at different degrees of maturation were examined. This work focused on early stages of osteocyte inclusion. This matrix inclusion occurred without a matrix synthesis inversion by the future osteocyte and with maintenance of close cell contacts with the replacing cell. A passive matrix embedding process related to a decreased activity of the osteoblast-osteocyte cell is proposed as a comprehensive pathway from osteoblast to osteocyte. The formation of the osteocyte is therefore presented as a very coordinated space and time related cell-cell interaction between cells of the three cell pools of the bone.
Nefussi
J R
JR
Laboratoire de Biologie-Odontologie, Université Paris VII, Paris, France.
Sautier
J M
JM
Nicolas
V
V
Forest
N
N
D000818:Animals; D001857:Bone Matrix / Q000166:cytology*; D002450:Cell Communication / Q000502:physiology; D002453:Cell Cycle; D002478:Cells, Cultured; D005333:Fetus; D010006:Osteoblasts / Q000502:physiology*; D010011:Osteocytes / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012886:Skull