title: Release of fluoride and metal ions from root surfaces after topical application of TiF4, SnF2, and NaF in vitro.
abstract: Aqueous solutions of TiF4 cause a rapid uptake and a long-lasting retention of fluoride when applied to dentin. The aim of this study was therefore to investigate the pattern of fluoride release after TiF4 application in vitro, compared with SnF2 and NaF application. TiF4, SnF2, and NaF were applied for 4 min and 1 min to standardized areas of six groups of root surface specimens immersed in distilled water. Untreated specimens were used as controls. The water was changed daily for 30 days, and F concentrations measured by an ion-selective electrode. All test groups showed a rapid decline in F concentration. In the 4-min group F concentration more than double the detection limit of the F electrode could be registered the first 28 days for TiF4, 11 days for SnF2, and 7 days for NaF. In the 1-min group periods of F registration were shorter. Analysis of Sn by atomic absorption spectrophotometry showed decreasing concentrations in the first 12-day samples in the 1-min and 4-min groups. Traces of Ti were found in the first few samples, but no pattern of release could be observed.
authors.affiliation: Department of Dental Research, School of Dentistry, University of Bergen, Norway.
authors.forename: L
authors.initials: L
authors.lastname: Skartveit
authors.forename: N R
authors.initials: NR
authors.lastname: Gjerdet
authors.forename: K A
authors.initials: KA
authors.lastname: Selvig
mesh_terms: D000287:Administration, Topical; D004577:Electron Probe Microanalysis; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology*; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D014001:Tin / Q000032:analysis / Q000493:pharmacokinetics*; D014002:Tin Fluorides / Q000008:administration & dosage / Q000494:pharmacology*; D014025:Titanium / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000494:pharmacology*; D014092:Tooth Root / Q000187:drug effects / Q000378:metabolism*
chemical_list: D014002:Tin Fluorides; D014001:Tin; D012969:Sodium Fluoride; D014025:Titanium; D005459:Fluorides; C032240:titanium tetrafluoride