The possible metabolic diversions adapted by the cockroach, Periplaneta americana to counteract the toxicity of fenvalerate.
Effects of sublethal doses of fenvalerate through topical application were monitored in the central nervous system (CNS) of P. americana. A decrease in total and soluble proteins with an increase in free amino acids, alanine aminotransferase (AlAT) and aspartate aminotransferase (AAT) was observed during fenvalerate toxicity. Further the levels of glycogen, pyruvate and activities of succinate dehydrogenase (SDH) and malate dehydrogenase (MDH) dropped significantly. Lactate content and lactate dehydrogenase (LDH) activity also showed an elevation following fenvalerate toxicity.
Reddy
A T
AT
Department of Zoology, S.V. University, Tirupati, India.
Yellamma
K
K
D000222:Adaptation, Physiological; D000287:Administration, Topical; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008291:Malate Dehydrogenase / Q000378:metabolism; D009570:Nitriles; D010526:Periplaneta / Q000187:drug effects* / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011722:Pyrethrins / Q000633:toxicity*; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D000596:Amino Acids; D007773:Lactates; D009570:Nitriles; D011506:Proteins; D011722:Pyrethrins; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D006003:Glycogen; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase; D001219:Aspartate Aminotransferases; C017690:fenvalerate