Tandem mass spectrometric approaches for determining exposure to alkylating agents.
Tandem mass spectrometric techniques have been developed for analysing alkylated purines in human urine. These techniques are designed with the objectives firstly of identifying unknown adducts derived from mixed exposures to alkylating agents, and secondly of quantifying these adducts with minimal sample purification.
Cushnir
J R
JR
MRC Toxicology Unit, Carshalton, Surrey, UK.
Lamb
J H
JH
Parry
A
A
Farmer
P B
PB
D000225:Adenine / Q000031:analogs & derivatives / Q000652:urine; D000477:Alkylating Agents / Q000378:metabolism*; D004784:Environmental Monitoring; D006147:Guanine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D013058:Mass Spectrometry
D000477:Alkylating Agents; C025946:3-methyladenine; D006147:Guanine; C008450:7-methylguanine; D000225:Adenine