title: Hypothermic protection following middle cerebral artery occlusion in the rat.
abstract: The effects of deep hypothermia on ischemic neuronal injury were examined using a permanent middle cerebral artery occlusion model in the rat. Animals were maintained at temporalis temperatures of either 24 degrees C or 36 degrees C and killed 6 hours after arterial occlusion. Normothermic rats displayed an average infarct volume of 25.1% +/- 1.6% of the right hemisphere, whereas hypothermic rats had an average infarct volume of 4.1% +/- 1.3% (p less than 0.001). The right/left hemispheric ratio was 1.05 +/- 0.02 in the normothermic group and 1.00 +/- 0.02 in the hypothermic group (p less than 0.05). These results suggest that hypothermia to 24 degrees C may reduce cerebral infarction and edema formation following middle cerebral artery occlusion in the rat.
authors.affiliation: Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, New York.
authors.forename: C J
authors.initials: CJ
authors.lastname: Baker
authors.forename: S T
authors.initials: ST
authors.lastname: Onesti
authors.forename: K N
authors.initials: KN
authors.lastname: Barth
authors.forename: C J
authors.initials: CJ
authors.lastname: Prestigiacomo
authors.forename: R A
authors.initials: RA
authors.lastname: Solomon
mesh_terms: D000818:Animals; D007036:Hypothermia, Induced; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR