[The effect of heparin and thromboplastin on the half-life of 125I-protein C in the blood flow of rats].
The influence of heparin and thromboplastin on the halflife of 125I-protein C in rat blood was under investigation. It was found that t1/2 of protein C was of 2.3 h. The intravenous administration of heparin resulted in the prolongation of t1/2 to 6.5 h, that could be explained by inhibition of thrombin generation. Upon the 40-min infusion of thromboplastin the rate of 125I-protein C decay in blood enhanced. That could be explained by the generation of the endogenous thrombin and participation of thrombomodulin in the protein C activation as well as in the removal of the endogenous thrombin from blood.
Kogan
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AE
Strukova
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SM
D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood / Q000139:chemically induced; D006207:Half-Life; D006493:Heparin / Q000494:pharmacology*; D007457:Iodine Radioisotopes; D011486:Protein C / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013925:Thromboplastin / Q000494:pharmacology*; D013997:Time Factors
D007457:Iodine Radioisotopes; D011486:Protein C; D006493:Heparin; D013925:Thromboplastin
Vliianie geparina i tromboplastina na vremia poluzhizni 125I-proteina C v krovotoke krys.