[Ofloxacin content in tears following topical use of 0.3% ointment].
Tear and aqueous humor levels of ofloxacin following 40mg of topical 0.3% ointment were determined at intervals within 24 hours by high performance liquid chromatography. The highest tear level was detected in half an hour, and effective concentrations existed in 6 hours. The highest aqueous humor level was detected 60 minutes after administration. Ofloxacin ointment produced higher tear concentrations for longer time than did aqueous solution of the drug.
Zhou
J S
JS
Shanxi Eye Hospital, Taiyuan.
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D008297:Male; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009824:Ointments; D011817:Rabbits; D013666:Tears / Q000378:metabolism*; D013997:Time Factors
D009824:Ointments; D015242:Ofloxacin