Drug oxidation and N-acetylation in rats pretreated with subtoxic doses of streptolysin O.
SLO in sublytic doses (100 HU/kg body wt) depressed the hepatic microsomal cytochrome P450 and aminopyrine-N-demethylase but increased significantly the cytosolic N-acetyltransferase after acute and subacute (5 days) pretreatment of male Wistar rats. Aniline hydroxylase was reduced after acute and unchanged after subacute pretreatment. The effects of SLO on the oxidative enzymes and drug N-acetylation might have been caused by the membranal and immunological properties of the toxin.
Hadasova
E
E
Department of Pharmacology, Medical Faculty T.G. Masaryk University Brno, Czechoslovakia.
Siegmund
W
W
Franke
G
G
Schneider
T
T
Beyrich
A
A
Bleyer
H
H
Hübner
G
G
D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism*; D001426:Bacterial Proteins; D001835:Body Weight / Q000187:drug effects; D003600:Cytosol / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010105:Oxygenases / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013301:Streptolysins / Q000494:pharmacology*
D001426:Bacterial Proteins; D004364:Pharmaceutical Preparations; D013301:Streptolysins; C025964:streptolysin O; D010105:Oxygenases; D000815:Aniline Hydroxylase; D001191:Arylamine N-Acetyltransferase