HPA-5b (Br(a)) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 cases.
Maternal alloimmunization against fetal platelets can cause fetal and neonatal thrombocytopenia (NAIT). The HPA-1a (PIA1, Zwa) antigen is by far the most common antigen implicated in NAIT. However, today another antigen often linked with that affection is HPA-5b (Br(a)). This is a report of 39 cases of NAIT involving the HPA-5b antigen. Thrombocytopenia may be of grave consequence. Three infants developed intracerebral haemorrhages (ICH). Of these, one died presumably as a consequence of ICH. Central nervous system (CNS) sequelae in the neonatal period was observed in two children. The potential hazards of death or disabling neurologic sequelae following intracerebral haemorrhage call for rapid and reliable diagnosis and effective therapy. Because there is high risk that subsequent pregnancies might be also affected by NAIT, the mothers of a previously affected child should be managed similarly to the HPA-1b mothers (PIA2, Zwb). The antenatal diagnosis of thrombocytopenia should be made and if necessary the in utero therapy instituted.
Kaplan
C
C
Institut National de Transfusion Sanguine, Service d'Immunologie Leuco-Plaquettaire, Paris, France.
Morel-Kopp
M C
MC
Kroll
H
H
Kiefel
V
V
Schlegel
N
N
Chesnel
N
N
Mueller-Eckhardt
C
C
D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology*; D001803:Blood Transfusion; D002543:Cerebral Hemorrhage / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D039661:Integrin beta3; D007518:Isoantibodies / Q000032:analysis; D007519:Isoantigens / Q000276:immunology*; D017713:Platelet Transfusion; D013921:Thrombocytopenia / Q000150:complications / Q000276:immunology* / Q000628:therapy
C055973:5b alloantigen, human; D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies; D007519:Isoantigens