Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid.
The effect of concentrations of linoleic acid (LA) on platelet aggregation was measured in seven healthy adult males. Subjects were randomly divided into two groups; these groups were fed natural food diets of identical composition except that one was high in LA (11.5% of energy) and low in oleic acid (OA) (7.4% of energy), the other was low in LA (4.5% of energy) and high in OA (15.7% of energy). The thresholds of ADP- and collagen-induced platelet aggregation were increased significantly by the high LA diet even though the intake of total fat and saturated fatty acids did not differ in these diets.
Burri
B J
BJ
US Department of Agriculture/Agriculture Research Service, Western Human Nutrition Research Center, Presidio of San Francisco, CA 94129.
Dougherty
R M
RM
Kelley
D S
DS
Iacono
J M
JM
D000244:Adenosine Diphosphate / Q000008:administration & dosage / Q000494:pharmacology; D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D003094:Collagen / Q000008:administration & dosage / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood
D004042:Dietary Fats, Unsaturated; D008041:Linoleic Acids; D009829:Oleic Acids; D014801:Vitamin A; D014810:Vitamin E; D019301:Oleic Acid; D000244:Adenosine Diphosphate; D000990:Antithrombin III; D003094:Collagen; D019787:Linoleic Acid