title: Effect of alpha-glucosidase inhibition on the nonenzymatic glycation of glomerular basement membrane.
abstract: 1. The effect of the alpha-glucosidase inhibitor Acarbose on integrated glycemic control and on nonenzymatic glycation of glomerular basement membrane was examined in streptozotocin diabetic rats. 2. Treatment with Acarbose for 8 weeks after induction of diabetes significantly reduced the level of HbA1c and of glomerular basement membrane glycation. 3. Acarbose exerts a significant antihyperglycemic effect and has a salutary influence on the nephropathic process in experimental diabetes.
authors.affiliation: University City Science Center, Philadelphia, PA 19104.
authors.forename: M P
authors.initials: MP
authors.lastname: Cohen
authors.forename: H
authors.initials: H
authors.lastname: Klepser
authors.forename: V Y
authors.initials: VY
authors.lastname: Wu
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000201:enzymology*; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D005947:Glucose / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D006909:Hydroxyproline / Q000378:metabolism; D066298:In Vitro Techniques; D007678:Kidney Glomerulus / Q000201:enzymology*; D008297:Male; D051381:Rats
chemical_list: D001786:Blood Glucose; D005947:Glucose; D006442:Glycated Hemoglobin; D065089:Glycoside Hydrolase Inhibitors; D006909:Hydroxyproline