Varicella-zoster infection in adults with cystic fibrosis: role of acyclovir.
Of 159 adult patients with cystic fibrosis, 5 were documented to have varicella-zoster infection that resulted in an infective pulmonary exacerbation that required intravenous acyclovir and additional antibiotic treatment. Stable serial pulmonary function values were observed over a 1-year period in 4 patients and no complications resulted from treatment. Early treatment with acyclovir in combination with appropriate antibiotics may prevent pulmonary deterioration in adult patients with cystic fibrosis who develop varicella-zoster infection.
Ong
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Regional Department of Infectious Diseases and Tropical Medicine, Monsall Hospital, University of Manchester School of Medicine, United Kingdom.
Mulvenna
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Webb
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KA
D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D002644:Chickenpox / Q000150:complications / Q000188:drug therapy*; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006562:Herpes Zoster / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011552:Pseudomonas Infections / Q000150:complications; D012129:Respiratory Function Tests; D012141:Respiratory Tract Infections / Q000150:complications
D000212:Acyclovir