title: Newly generated IgE antibodies to Dermatophagoides pteronyssinus in children are directed against components distinct from Der p I and Der p II.
abstract: The specificity of newly generated IgE antibodies (Abs) to the house dust mite, Dermatophagoides pteronyssinus, in longitudinal serum samples from 18 young children with an increased risk for IgE-mediated allergy was studied. The first IgE Ab response to house dust mite was detected early in life (mean age, 32 months; range, 11 to 60 months). For 83% of the children, more than half of the newly generated IgE Ab response to house dust mite was directed against components distinct from the major allergens, Der p I (Pl) and Der p II (DpX). These results suggest that the early IgE Ab response to house dust mite is induced by components distinct from the major allergens, Der p I and Der p II.
authors.affiliation: Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam.
authors.forename: P G
authors.initials: PG
authors.lastname: Calkhoven
authors.forename: M
authors.initials: M
authors.lastname: Aalbers
authors.forename: P P
authors.initials: PP
authors.lastname: Schilte
authors.forename: B J
authors.initials: BJ
authors.lastname: Yntema
authors.forename: R W
authors.initials: RW
authors.lastname: Griffioen
authors.forename: J C
authors.initials: JC
authors.lastname: van Nierop
authors.forename: A P
authors.initials: AP
authors.lastname: Oranje
authors.forename: R C
authors.initials: RC
authors.lastname: Aalberse
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D002675:Child, Preschool; D004391:Dust; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000276:immunology; D007223:Infant; D008925:Mites / Q000276:immunology*; D011852:Radioallergosorbent Test
chemical_list: D000485:Allergens; D000906:Antibodies; D004391:Dust; D007073:Immunoglobulin E