title: [Pathogenetic mechanisms of stress-induced aggravation of experimental influenza and its prevention].
abstract: It was stated that in stress-induced aggravation of infection realized in transformation of nonlethal patterns of infection into a lethal one there occurred a manifest dysfunction of hypothalamo-hypophyseal-neurosecretory performance (HHNS) featured by a 2-fold decrease in the blood vasopressin and an essential elevation of the hypothalamic one. The phenomenon is being suggestive of a possible blockage in the hormonal discharge into circulation and the limitation of its participation in the development of defensive and compensatory reactions. Identical HHNS dysfunction was noted in the lethal pattern of the infection. The authors formulated the concept of the main pathogenetic points underlying the damage of vegetative regulation centres. Mechanisms of viral and tissue metabolic damage of CNS were revealed. The authors substantiated the advisability and prospective use+ of antioxidants as applied to the prevention of severe course of influenza and its complications in extremely aggravated patterns.
authors.forename: B A
authors.initials: BA
authors.lastname: Frolov
authors.forename: R Ia
authors.initials: RIa
authors.lastname: Poliak
authors.forename: G N
authors.initials: GN
authors.lastname: Smagin
authors.forename: A A
authors.initials: AA
authors.lastname: Nikonorov
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Kul'divatov
authors.forename: L K
authors.initials: LK
authors.lastname: Chetverikova
authors.forename: L I
authors.initials: LI
authors.lastname: Inozemtseva
authors.forename: V K
authors.initials: VK
authors.lastname: Filippov
authors.forename: T A
authors.initials: TA
authors.lastname: Kramskaia
authors.forename: A A
authors.initials: AA
authors.lastname: Stadnikov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001921:Brain / Q000378:metabolism*; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage*; D004195:Disease Models, Animal; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000378:metabolism*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D002084:Butylated Hydroxytoluene
vernacular_title: Patogeneticheskie mekhanizmy stressovogo usugubleniia éksperimental'noĭ grippoznoĭ infektsii i ego preduprezhdenie.