[Plasma MHPG, peripheral noradrenergic marker and hormonal plasma levels of cortisol-T3-T4-TSH in depressive syndromes].
Based on the hypocatecholaminergic hypothesis in the depressive syndromes, this survey on 30 depressed patients compared to 21 control patients, attempts to state exactly the potential interactions between the noradrenergic system and the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid neuroendocrine axis. The biological indices used during this survey are: total plasmatic MHPG, the basic plasmatic cortisol, the thyroid hormones T3, T4, free T4, and the TSH. The results of this survey reveal a significative increase of the basic plasmatic cortisol among the depressed patients, including dysthymics, a decrease of the plasmatic MHPG during major depressions, and a significant fall of the total T3 among depressed men, as well as some correlations between the different axes, the interpretation of which remains "ticklish".
Bottai
T
T
Service de Pharmacologie Clinique et de Psychiatrie Biologique, Groupe Hospitalier de la Timone, Marseille.
Levy
C
C
Lancon
C
C
Azorin
J M
JM
Grignon
S
S
Valli
M
M
Jadot
G
G
Tissot
R
R
D000328:Adult; D000368:Aged; D002395:Catecholamines / Q000378:metabolism; D003348:Cortisone / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood*; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D002395:Catecholamines; D013963:Thyroid Hormones; D014284:Triiodothyronine; D008734:Methoxyhydroxyphenylglycol; D013972:Thyrotropin; D013974:Thyroxine; D003348:Cortisone
Contribution á l'étude du MHPG plasmatique marqueur noradrénergique périphérique et des taux plasmatiques hormonaux de cortisol-T3-T4-TSH dans les syndromes dépressifs.