[Experimental study of the inhibitory effect of daunorubicin and doxorubicin in conjunctival fibroblast proliferation].
Both daunorubicin and doxorubicin were found effective in inhibiting proliferation of rabbit conjunctival fibroblasts in vitro. The 50% inhibition dose for daunorubicin was 0.14 micrograms/ml, and 0.46 micrograms/ml for doxorubicin, the former being stronger. The authors were hopeful that these drugs would prove useful in preventing cicatrization after glaucoma filter surgery.
Xu
Y
Y
Henan Institute of Ophthalmology, Zhengzhou.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003228:Conjunctiva / Q000166:cytology* / Q000187:drug effects; D003630:Daunorubicin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D066298:In Vitro Techniques; D011817:Rabbits
D004317:Doxorubicin; D003630:Daunorubicin