title: Maximum likelihood techniques applied to method comparison studies.
abstract: One component of method comparison studies is the assessment of relative bias. Most authors use ordinary regression techniques for this purpose. The potential inadequacies in this approach are highlighted and a more generally applicable maximum likelihood technique proposed. The properties of the various methods of estimation are obtained by means of a simulation study, using a variety of different within-assay precision profiles.
authors.affiliation: School of Mathematics, University of Wales, College of Cardiff, U.K.
authors.forename: A B
authors.initials: AB
authors.lastname: Nix
authors.forename: F D
authors.initials: FD
authors.lastname: Dunstan
mesh_terms: D000465:Algorithms; D015982:Bias; D012044:Regression Analysis; D013223:Statistics as Topic