Neutrophil as a mediator of ischemic edema formation in the brain.
We investigated the contribution of neutrophils to brain edema formation using a transient focal ischemia model in rats. Rats were given anti-neutrophil monoclonal antibody (RP3) intraperitoneally to deplete circulating neutrophils. In RP3-treated rats, ischemic brain edema formation 1 day after reperfusion was significantly decreased compared to that of saline-treated control rats. We speculate that chemical mediators released by infiltrating neutrophils alter vascular permeability and play an important role in post-ischemic brain edema formation.
Shiga
Y
Y
Department of Neurology, Tohoku University, School of Medicine, Sendai, Japan.
Onodera
H
H
Kogure
K
K
Yamasaki
Y
Y
Yashima
Y
Y
Syozuhara
H
H
Sendo
F
F
D000818:Animals; D000911:Antibodies, Monoclonal; D001834:Body Water / Q000737:chemistry; D001929:Brain Edema / Q000473:pathology / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009504:Neutrophils / Q000473:pathology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D015424:Reperfusion; D013997:Time Factors
D000911:Antibodies, Monoclonal