title: Erythropoietin concentrations in obstructive sleep apnoea.
abstract: Eight patients with obstructive sleep apnoea and a normal haemoglobin concentration underwent nocturnal studies during which oxyhaemoglobin saturation was recorded continuously with an ear oximeter and serum erythropoietin concentration was measured hourly by means of a radioimmunoassay. Serum erythropoietin concentrations remained within the normal range throughout the study despite falls in oxyhaemaglobin saturation in individuals to 33-78%. There was no relation between the degree of nocturnal hypoxaemia and serum erythropoietin concentrations. The brief cyclical episodes of hypoxaemia typical of obstructive sleep apnoea may not be a sufficient stimulus for erythropoietin secretion.
authors.affiliation: David Read Laboratory, Royal Prince Alfred Hospital, Camperdown NSW, Australia.
authors.forename: J M
authors.initials: JM
authors.lastname: Goldman
authors.forename: R M
authors.initials: RM
authors.lastname: Ireland
authors.forename: M
authors.initials: M
authors.lastname: Berthon-Jones
authors.forename: R R
authors.initials: RR
authors.lastname: Grunstein
authors.forename: C E
authors.initials: CE
authors.lastname: Sullivan
authors.forename: J C
authors.initials: JC
authors.lastname: Biggs
mesh_terms: D000328:Adult; D000368:Aged; D004921:Erythropoietin / Q000097:blood*; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010108:Oxyhemoglobins / Q000032:analysis; D012891:Sleep Apnea Syndromes / Q000097:blood* / Q000150:complications
chemical_list: D010108:Oxyhemoglobins; D004921:Erythropoietin