[Formation of target cells in the immunocompetent organ (spleen) of mice with experimental infection caused by influenza A viruses with various properties].
The article presents the data on the time-course of formation of ++virus-pecific target-cells in spleens of mice infected with various types of influenza caused by a virulent viral strain and its avirulent ts-mutation. It was demonstrated that these target-cells occurred in all studied patterns of infection. Their formation turned to be of cyclic character, dose-dependent and closely related with the formation of all known mechanisms of specific and nonspecific cellular defense. The presentation pattern of viral antigens on the surface of these target-cells turned to be variable in the course of the infections evidenced their different recognition in the reactions with the participation of +virus-specific antibodies of effectual cells.
Shidlovskaia
N K
NK
Dubrovina
T Ia
TIa
Poliak
R Ia
RIa
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000276:immunology / Q000473:pathology*; D000956:Antigens, Viral / Q000276:immunology*; D004195:Disease Models, Animal; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000473:pathology*; D013154:Spleen / Q000473:pathology*; D014779:Virus Replication / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral
Obrazovanie kletok-misheneĭ v immunokompetentnom organe (selezenke) mysheĭ v dinamike éksperimental'noĭ infektsii, vyzvannoĭ virusami grippa A s raznymi svoĭstvami.