Chinese tea inhibits the occurrence of oesophageal tumours induced by N-nitrosomethylbenzylamine and blocks its formation in rats.
Chinese tea can inhibit the occurrence of oesophageal tumours not only by blocking the formation of N-nitrosomethylbenzylamine (NMBzA) in vivo, but also by inhibiting the carcinogenesis of preformed NMBzA. The incidence of oesophageal tumours in rats intubated with preformed NMBzA (5 mg/kg bw per week) and with the precursors of NMBzA (methylbenzylamine, 1 mM/kg bw; nitrite, 0.5 mM/kg bw) without Chinese tea was higher than in tea-treated groups; the same tendency was found with regard to the severity of the oesophageal lesions. The anticarcinogenic effects of five varieties of Chinese tea were different from one another.
Han
C
C
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing.
Xu
Y
Y
D000818:Animals; D002273:Carcinogens; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013662:Tea
D002273:Carcinogens; D013662:Tea; C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine