Deuterium-labelled p-tyramine challenge test and phenolsulfotransferase activity in depressed patients--failure to replicate decreased p-tyramine conjugation in depression.
1. Depressed and normal subjects were challenged with deuterium-labelled p-tyramine and urine was collected for 3 h. 2. Urinary excretion of conjugated p-tyramine was not significantly different between normal, melancholic and non-melancholic depressed subjects. 3. Platelet phenolsulfotransferase activity to p-tyramine (p less than 0.05) and to phenol (p less than 0.005) were significantly lower in the depressed patients.
Davis
B A
BA
Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon.
Boulton
A A
AA
Yu
P H
PH
Durden
D A
DA
Bowen
R C
RC
Keegan
D L
DL
Blackshaw
S
S
D'Arcy
C
C
Remillard
A J
AJ
Dayal
N
N
D000639:Amitriptyline / Q000494:pharmacology; D015239:Arylsulfotransferase / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D003866:Depressive Disorder / Q000175:diagnosis / Q000201:enzymology* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011897:Random Allocation; D014439:Tyramine / Q000378:metabolism
D005473:Fluoxetine; D000639:Amitriptyline; D015239:Arylsulfotransferase; D014439:Tyramine