title: Comparative study of sucralfate 2 grams twice daily versus sucralfate 1 gram four times daily in the treatment of benign gastric ulcers in outpatients.
abstract: In a double-blind, randomized study, we compared the healing of gastric ulcer during a twice-daily regimen of 2 g sucralfate or sucralfate 1 g q.i.d. Patients receiving the former therapy received the tablets one-half hour before breakfast and at bedtime. Patients receiving sucralfate 1 g q.i.d. received their therapy 30 minutes before breakfast, lunch, and supper, and at bedtime. The study included 52 patients with endoscopically proven gastric ulcer; 41 patients completed the study. Healing was endoscopically assessed at 8 weeks and 12 weeks. After 8 and 12 weeks the healing rate for sucralfate 2 g b.i.d. was 67% and 92%, respectively; the healing rate of sucralfate 1 g q.i.d. was 59% and 71%, respectively. No statistically significant difference was found between the two regimens. The results suggest that 2 g sucralfate twice daily is as effective in the healing of gastric ulcer as 1 g sucralfate q.i.d.
authors.affiliation: Department of Medicine, University of Natal/King Edward VIII Hospital, Congella, Durban, South Africa.
authors.forename: A E
authors.initials: AE
authors.lastname: Simjee
authors.forename: K E
authors.initials: KE
authors.lastname: Pettengell
authors.forename: J M
authors.initials: JM
authors.lastname: Spitaels
mesh_terms: D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D004311:Double-Blind Method; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011446:Prospective Studies; D013276:Stomach Ulcer / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D013392:Sucralfate / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects
chemical_list: D013392:Sucralfate