Possible mechanism of the gastroprotective activity elicited by some copper(II) complexes.
The gastroprotective activity of some copper(II) complexes has been previously described. Since mucus secretion may be a factor responsible for their gastroprotective activity, this study was designed to determine the influence of these compounds on mucous secretion in rat. The copper complexes assayed at a dose of 25 mg/kg significantly increased mucous secretion. Pre-treatment with indometacin, a cyclooxygenase inhibitor, does not influence the mucostimulant properties of these compounds. However, the effect on mucus secretion was significantly decreased by pre-treatment with a depletor of endogenous thiols, n-ethylmaleimide. These results suggest the additional role of sulfhydryl groups in the mucosal gastroprotective effect of copper(II) complexes.
Frechilla
D
D
Departamento de Farmacologia, Universidad de Navarra, Pamplona, Spain.
Lasheras
B
B
Ucelay
M
M
Parrondo
E
E
Craciunescu
G
G
Cenarruzabeitia
E
E
D000818:Animals; D003300:Copper / Q000627:therapeutic use*; D005033:Ethylmaleimide / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009093:Mucus / Q000378:metabolism; D011453:Prostaglandins / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D011453:Prostaglandins; D013438:Sulfhydryl Compounds; D003300:Copper; D005033:Ethylmaleimide; D007213:Indomethacin