[The pharmacokinetic and pharmacodynamic characteristics of diazepam in different populations of rats].
Significant differences in diazepam pharmacokinetics in different populations of rats both within one family and within one species were revealed. A high degree of correlation between the pharmacokinetic parameters and pharmacodynamic indices indicates that the myorelaxant effect is in a direct dependence on diazepam concentration in the rat organism.
Zherdev
V P
VP
Dvorianikov
A A
AA
Kolyvanov
G B
GB
Savchenko
I V
IV
D000818:Animals; D003975:Diazepam / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D051381:Rats / Q000378:metabolism*; D011919:Rats, Inbred Strains; D016205:Sigmodontinae; D013045:Species Specificity; D013997:Time Factors
D003975:Diazepam
Izuchenie osobennosteĭ farmakokinetiki i farmakodinamiki diazepama u krys razlichnykh populiatsiĭ.