[Familial adult cystic kidneys and malignant teratomas after kidney transplantation with cyclosporin therapy].
We report on two brothers with adult polycystic kidney disease, malignant teratomas and other genital malformations. Because of the unusual accumulation of malformations of embryologically related organs, we postulate a connection between malformations of the kidneys and the genital tract, on the one hand, and teratomas on the other. No genetic coherence is known so far. It is unlikely that immunosuppression with cyclosporin after transplantation had caused these tumours.
Rinderknecht
B P
BP
Institut für Pathologie, Universität Basel, Schweiz.
Ambs
K E
KE
Huser
B
B
Rist
M
M
Landmann
J
J
Mihatsch
M J
MJ
D000328:Adult; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D010375:Pedigree; D007690:Polycystic Kidney Diseases / Q000235:genetics* / Q000601:surgery; D011183:Postoperative Complications / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D012186:Retroperitoneal Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D013724:Teratoma / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D013736:Testicular Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D013737:Testis / Q000473:pathology
D003524:Cyclosporins
Familiäre adulte Zystennieren und maligne Teratome nach Nierentransplantation unter Ciclosporintherapie.