2,3-butanediol in experimental myocardial ischaemia in pigs.
To investigate the role of 2,3-butanediol in myocardial ischaemia we analysed this compound in pig's myocardium and blood. Ischaemia was induced by ligation of a coronary artery. In the first study we found significantly higher levels of 2,3-butanediol in the homogenate of ischaemic myocardium than in non-ischaemic myocardium. The lactate concentration was also significantly elevated. In the second study, where ischaemia was similarly induced, and where reperfusion was achieved by re-opening the ligated coronary artery after 20 min, 2,3-butanediol in peripheral blood was found to increase significantly. In the pigs in which the coronary artery was not re-opened, the 2,3-butanediol level in peripheral blood was unchanged. We conclude that in pigs' anaerobic myocardia accumulation of 2,3-butanediol occurs; if the myocardium is reperfused this metabolite also appears in the blood.
Heer
K R
KR
Departement Forschung Kantonsspital Basel, Switzerland.
Althaus
U
U
Mettler
D
D
Schilt
W
W
Thoelen
H
H
D000818:Animals; D002072:Butylene Glycols / Q000032:analysis* / Q000097:blood; D003327:Coronary Disease / Q000378:metabolism*; D003331:Coronary Vessels; D007511:Ischemia / Q000378:metabolism; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D009206:Myocardium / Q000737:chemistry* / Q000378:metabolism; D013552:Swine
D002072:Butylene Glycols; D007773:Lactates; D019344:Lactic Acid; C026978:2,3-butylene glycol