title: Intraoperative determination of mediastinal constraints for a total artificial heart.
abstract: The anatomic constraints to mediastinal fit of a total artificial heart (TAH) were largely neglected during the early developmental stages, precipitating failure due to compression or torsion of intrathoracic conduits and vascular structures. Cadaveric studies quantifying anatomic constraints are limited by postmortem factors causing distortion of critical structures. This study defines the anatomic constraints and parameters necessary for designing an implantable TAH. Importantly, these parameters were measured in 12 consecutive patients undergoing orthotopic cardiac transplant (mean body surface area, 2.0 +/- 0.1 m2) after native heart amputation. A full sized contour model of the cylindrical TAH (diameter, 97 mm; width, 78 mm) was inserted into the pericardial cavity to verify fit, which was found adequate in each case, with no identifiable compression of adjacent vascular structures. Intraoperative measurements obtained define intrathoracic and pericardial constraints for a cardiac prosthesis (mean pericardial dimensions: length, 133.0 mm; width, 154.0 mm; depth, 129.0 mm). The parameters measured will provide useful reference for other prosthetic devices, since they were obtained intraoperatively rather than postmortem. The current dimensions of our TAH were found to be acceptable for orthotopic implantation.
authors.affiliation: Department of Surgery, Methodist Hospital, Houston, Texas.
authors.forename: A S
authors.initials: AS
authors.lastname: Shah
authors.forename: M
authors.initials: M
authors.lastname: Shiono
authors.forename: T
authors.initials: T
authors.lastname: Jikuya
authors.forename: S
authors.initials: S
authors.lastname: Takatani
authors.forename: M E
authors.initials: ME
authors.lastname: Sekela
authors.forename: G P
authors.initials: GP
authors.lastname: Noon
authors.forename: J B
authors.initials: JB
authors.lastname: Young
authors.forename: Y
authors.initials: Y
authors.lastname: Nosé
authors.forename: M E
authors.initials: ME
authors.lastname: DeBakey
mesh_terms: D000328:Adult; D000368:Aged; D006354:Heart, Artificial; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008482:Mediastinum / Q000033:anatomy & histology*; D008875:Middle Aged; D011474:Prosthesis Design