Comparison of the effect of temafloxacin, ciprofloxacin, or placebo on cerebral blood flow, glucose, and oxygen metabolism in healthy subjects by means of positron emission tomography.
OBJECTIVE
To determine the cause of the central nervous system effect of the fluorinated quinolones temafloxacin and ciprofloxacin by measuring cerebral blood flow and metabolism by use of positron emission tomography.


METHODS
This was a prospective, randomized, double-blind, placebo-controlled study.


METHODS
The patients were 13 healthy, nonsmoking volunteers whose ages ranged from 18 to 40 years.


RESULTS
We measured brain blood flow and metabolism by use of positron emission tomography before and after a five-dose course of 750 mg ciprofloxacin, 600 mg temafloxacin, or placebo given every 12 hours. Quinolone administration produced no significant effect on visual (qualitative) reading of the positron emission tomography scans.


CONCLUSIONS
We conclude that short-term administration of temafloxacin, ciprofloxacin, or placebo does not significantly alter cerebral glucose or oxygen metabolism. Subjects treated with ciprofloxacin demonstrated a significant decrease in brain blood flow compared with baseline and with temafloxacin- or placebo-treated subjects.
Bednarczyk
E M
EM
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Green
J A
JA
Nelson
A D
AD
Leisure
G A
GA
Little
D
D
Adler
L P
LP
Berridge
M S
MS
Panacek
E A
EA
Miraldi
F D
FD
D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000494:pharmacology*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002939:Ciprofloxacin / Q000009:adverse effects / Q000494:pharmacology*; D003847:Deoxyglucose / Q000378:metabolism; D004311:Double-Blind Method; D024841:Fluoroquinolones; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010919:Placebos; D011446:Prospective Studies; D015363:Quinolones; D012016:Reference Values; D014055:Tomography, Emission-Computed
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010919:Placebos; D015363:Quinolones; C054745:temafloxacin; D002939:Ciprofloxacin; D003847:Deoxyglucose; D005947:Glucose; D010100:Oxygen