title: External cardiopulmonary resuscitation preserves brain viability after prolonged cardiac arrest in dogs.
abstract: Standard external cardiopulmonary resuscitation (CPR) steps A-B-C produce a low blood flow that may or may not preserve brain viability during prolonged cardiac arrest. A dog model was used with ventricular fibrillation (VF) of 20 minutes, reperfusion with brief cardiopulmonary bypass, controlled ventilation to 20 hours, and intensive care to 96 hours. A retrospective comparison was made of the results of one series, now called "group I" (n = 10)--which received CPR basic life support interposed from VF 10 to 15 minutes, and CPR advanced life support with epinephrine (without defibrillation) from VF 15 to 20 minutes--to the results of another series, now "control group II" (n = 10)--which received VF no flow (no CPR) for 20 minutes. All 20 dogs within protocol were resuscitated. All 10 of group I and 7 of 10 of group II survived to 96 hours. Pupillary light reflex returned after the start of cardiopulmonary bypass at 7.7 +/- 3.7 minutes in CPR group I, versus 16.3 +/- 7.4 minutes in control group II (P = .032). At 96 hours postarrest, final overall performance categories (1, normal; 5, brain death) were better in group I. Six of 10 dogs achieved normality (overall performance category 1) in group I, as compared with none of 10 in group II (P = .004). Final neurologic deficit score (0%, best; 100% worst) was lower (better) in group I (15% +/- 20%) than in group II (51% +/- 6%; P less than .001).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesiology, University of Pittsburgh, PA.
authors.forename: M
authors.initials: M
authors.lastname: Angelos
authors.forename: P
authors.initials: P
authors.lastname: Safar
authors.forename: H
authors.initials: H
authors.lastname: Reich
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000502:physiology; D002545:Brain Ischemia / Q000517:prevention & control; D004285:Dogs; D004554:Electric Countershock; D006321:Heart / Q000502:physiology; D006323:Heart Arrest / Q000503:physiopathology*; D008020:Life Support Care / Q000379:methods*; D012151:Resuscitation / Q000379:methods*; D012189:Retrospective Studies; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000503:physiopathology