title: The structural and functional consequences of acoustic injury in the cochlea and peripheral auditory system: a five year update.
abstract: This presentation considers important developments and new trends related to acoustic injury in the peripheral auditory system reported during the past 5 years. The discussion begins with the effect overstimulation has on the "active" cochlear process, and the associated loss in receptive field (tuning curve) selectivity. Exposure to intense sound also changes the structure and function of the tectorial membrane, sensory hair bundles, tip links, and intracellular organelles. All of these injuries may change the way in which energy is delivered to the transduction channels of the hair cell. Important new evidence describing the quantitative relation between hair cell loss and permanent hearing loss is reviewed, and the possibility that specific exposure conditions cause unique lesions to the inner or outer hair cells is explored. Finally, the importance of hair cell regeneration in the chick cochlea, changes in the CNS following acoustic injury, and the cochlear vascular system are considered.
authors.affiliation: Department of Otorhinolaryngology and Human Communication, University of Pennsylvania, Philadelphia 19104.
authors.forename: J C
authors.initials: JC
authors.lastname: Saunders
authors.forename: Y E
authors.initials: YE
authors.lastname: Cohen
authors.forename: Y M
authors.initials: YM
authors.lastname: Szymko
mesh_terms: D000818:Animals; D001309:Auditory Threshold / Q000502:physiology*; D001489:Basilar Membrane / Q000502:physiology; D003051:Cochlea / Q000502:physiology*; D006198:Hair Cells, Auditory / Q000502:physiology; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D006801:Humans; D008144:Loudness Perception / Q000502:physiology; D010898:Pitch Perception / Q000502:physiology; D011571:Psychoacoustics