Modifications of the biosynthesis of type-I and type-III collagens and fibronectin during diabetes and atherosclerosis.
Results show that diabetes, which is a major risk factor for arterio-atherosclerosis, mimicks an accelerated aging, at least as far as the thickening of basement membranes and fibronectin and collagen biosynthesis are concerned. A similar sequence of events could be demonstrated in human atherosclerotic plaque formation. In conclusion, we could demonstrate a disregulation of extracellular matrix components biosynthesis (type-III collagen and fibronectin) in diabetes and atherosclerosis.
Labat-Robert
J
J
Laboratoire de Biologie du Tissu Conjonctif, UA CNRS 1460, Faculté de Médecine, Créteil, France.
Kern
P
P
Robert
L
L
D000368:Aged; D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology*; D001485:Basement Membrane / Q000473:pathology; D001706:Biopsy; D002196:Capillaries / Q000473:pathology; D003094:Collagen / Q000096:biosynthesis*; D003228:Conjunctiva / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology; D005109:Extracellular Matrix / Q000473:pathology; D005353:Fibronectins / Q000096:biosynthesis*; D005881:Gingiva / Q000473:pathology; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D051381:Rats; D012867:Skin / Q000473:pathology
D005353:Fibronectins; D003094:Collagen