title: [Long-term therapy of Ménétrier disease using ranitidine and pirenzepine].
abstract: A 22-year-old woman with hypertrophic protein-losing gastropathy (Ménétrier's disease) is described. During treatment with ranitidine (Zantic) and pirenzepine (Gastrozepin) the gastric mucosa and protein loss were normalized within 4 years. Clinical and histological remission has now been observed for 5 and 3 years respectively. In a 57-year-old woman with hypertrophic gastropathy, 8 months' treatment with ranitidine and pirenzepine was associated with decrease in protein loss and improvement of the histological appearance of the gastric mucosa after one year. Long-term treatment of hypertrophic gastropathy with ranitidine and/or pirenzepine should, therefore, be considered in such cases instead of gastrectomy.
authors.affiliation: Departement für Innere Medizin, Universitätsspital Zürich.
authors.forename: C
authors.initials: C
authors.lastname: Meyenberger
authors.forename: J
authors.initials: J
authors.lastname: Altorfer
authors.forename: R
authors.initials: R
authors.lastname: Münch
authors.forename: A
authors.initials: A
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Ammann
mesh_terms: D000328:Adult; D001706:Biopsy; D004359:Drug Therapy, Combination; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005758:Gastritis, Hypertrophic / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010890:Pirenzepine / Q000627:therapeutic use*; D011899:Ranitidine / Q000627:therapeutic use*
chemical_list: D010890:Pirenzepine; D011899:Ranitidine
vernacular_title: Langzeittherapie des Morbus Ménétrier mit Ranitidin und Pirenzepin.