[Changes in plasma levels of corticosterone, testosterone and estradiol and their receptors in the lung cytosol in experimental fibrosing process in the lungs].
The content of blood plasma corticosterone, testosterone and estradiol, and receptors to corticosteroids, androgens and estrogens in pulmonary cytosol of normal male rats and those with fibrosing process in the lungs were experimentally studied by means of radioimmunoassay. With pulmonary fibrosis, a decrease in the concentration of blood plasma corticosterone and testosterone, and lower content of their pulmonary cytosol receptors to corticosteroids, androgens and estrogens are observed. As testosterone propionate was administered in the course of this experiment, there was a normalization of blood plasma corticosterone levels and those of the pulmonary cytosol receptors to androgens. The content of blood plasma testosterone and the pulmonary cytosol receptors to corticosteroids and estrogens was partially normalized. However, it was significantly different from the indices in the control group.
Tadzhiev
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D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism*; D004195:Disease Models, Animal; D004958:Estradiol / Q000097:blood*; D008168:Lung / Q000378:metabolism*; D008297:Male; D011658:Pulmonary Fibrosis / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011944:Receptors, Androgen / Q000378:metabolism*; D011959:Receptors, Estradiol / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D013739:Testosterone / Q000097:blood / Q000378:metabolism*
D011944:Receptors, Androgen; D011959:Receptors, Estradiol; D011965:Receptors, Glucocorticoid; D013739:Testosterone; D004958:Estradiol; D003345:Corticosterone
Izmenenie soderzhaniia kortikosterona, testosterona, estradiola v plazme krovi i ikh retseptorov v tsitozole legkikh pri éksperimental'nom fibroziruiushchem protsesse v legkikh.