title: Synthesis and nematocidal activities of jietacin A and its analogs.
abstract: Simple, efficient syntheses of jietacin A, a nematocidal antibiotic, and its analogs have been developed in order to study structure-activity relationships. A series of alpha,beta-unsaturated azoxy compounds was prepared from phenylselenomethyl azoxy compounds as key intermediates and its nematocidal activity was determined.
authors.affiliation: Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsuzuki
authors.forename: F S
authors.initials: FS
authors.lastname: Yan
authors.forename: K
authors.initials: K
authors.lastname: Otoguro
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009348:Nematoda / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000969:Antinematodal Agents; D001391:Azo Compounds; C053336:jietacin A