Peritonitis due to Prototheca wickerhamii in a patient undergoing chronic ambulatory peritoneal dialysis.
A 72-year-old man who was undergoing chronic ambulatory peritoneal dialysis developed peritonitis due to Prototheca wickerhamii. Results of in vitro sensitivity testing revealed that the organism was sensitive to amphotericin B (MIC, 0.4 micrograms/mL) but resistant to fluconazole (MIC, greater than 80 micrograms/mL). The patient was successfully treated medically with a combination of intravenous amphotericin B and oral doxycycline.
Sands
M
M
Department of Internal Medicine, Baystate Medical Center, Springfield, Massachusetts 01199.
Poppel
D
D
Brown
R
R
D000284:Administration, Oral; D000368:Aged; D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D007239:Infections / Q000188:drug therapy / Q000209:etiology; D007275:Injections, Intravenous; D008297:Male; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010538:Peritonitis / Q000188:drug therapy / Q000209:etiology*; D011525:Prototheca / Q000187:drug effects / Q000302:isolation & purification*
D000666:Amphotericin B; D015725:Fluconazole; D004318:Doxycycline