Maximum likelihood techniques applied to method comparison studies.
One component of method comparison studies is the assessment of relative bias. Most authors use ordinary regression techniques for this purpose. The potential inadequacies in this approach are highlighted and a more generally applicable maximum likelihood technique proposed. The properties of the various methods of estimation are obtained by means of a simulation study, using a variety of different within-assay precision profiles.
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School of Mathematics, University of Wales, College of Cardiff, U.K.
Dunstan
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D000465:Algorithms; D015982:Bias; D012044:Regression Analysis; D013223:Statistics as Topic