title: [Binding of cefuroxime to macromolecules from bronchitic sputum in patients with chronic bronchitis].
abstract: Cefuroxime binding to soluble bronchial macromolecules has been performed in vitro with preparations obtained from ten patients. Cefuroxime at various concentrations have been added to soluble macromolecules (10 g/l). Free cefuroxime has been obtained by equilibrium dialysis and measured by HPLC. Results show that cefuroxime binding is about 30% of total antibiotic.
authors.affiliation: Unité des Protéines, INSERM (n.16), Lille.
authors.forename: M
authors.initials: M
authors.lastname: Lhermitte
authors.forename: D
authors.initials: D
authors.lastname: Chiche
authors.forename: N
authors.initials: N
authors.lastname: Houdret
authors.forename: P
authors.initials: P
authors.lastname: Roussel
mesh_terms: D001991:Bronchitis / Q000378:metabolism*; D002444:Cefuroxime / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D006801:Humans; D066298:In Vitro Techniques; D013183:Sputum / Q000187:drug effects* / Q000378:metabolism
chemical_list: D002444:Cefuroxime
vernacular_title: Liaison de la céfuroxime aux macromolécules du mucus bronchique de malades atteints de bronchite chronique.