Diminazene aceturate residues in the tissues of healthy, Trypanosoma congolense and Trypanosoma brucei brucei infected dogs.
The tissue distribution and residue profile of diminazene aceturate was investigated in healthy dogs and in dogs infected with Trypanosoma congolense and Trypanosoma brucei brucei. The drug was administered at 3.5 mg/kg i.m. and tissue samples were taken post mortem from the animals at 48, 72, 120, 168 and 240 h after injection. The drug was distributed to various organs and tissues of the body with the highest concentrations occurring in liver and kidney. Higher drug levels were obtained in the tissues of healthy dogs compared with trypanosome infected animals except in the brain. The levels of residues in the healthy animals were significantly different (P less than 0.05) from those of the infected dogs. The drug residues were still detectable in the tissues of the animals 10 days after drug administration.
Onyeyili
P A
PA
Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria.
Anika
S M
SM
D000818:Animals; D004133:Diminazene / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D004350:Drug Residues / Q000493:pharmacokinetics*; D005260:Female; D008297:Male; D014344:Trypanocidal Agents / Q000493:pharmacokinetics*; D014346:Trypanosoma brucei brucei; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000378:metabolism / Q000662:veterinary*
D014344:Trypanocidal Agents; C003915:diminazene aceturate; D004133:Diminazene