title: Effects of dietary pantethine levels on contents of fatty acids and thiobarbituric acid reactive substances in the liver of rats orally administered varying amounts of autoxidized linoleate.
abstract: The effects of dietary pantethine levels on the contents and compositions of fatty acids and on the levels of lipid peroxides were investigated with rat liver and its S-9 fraction under administration of 0 (non), 0.2 (low dose), and 0.35 ml (high dose) of autoxidized linoleate (AL) per 100 g body weight of the rats per day for 5 days. AL having 800 meq/kg of peroxide value (PV) and 1,700 meq/kg of carbonyl value (CV) was dosed to the rats of each group given drinking water containing 0 mg% (deficient), 6.25 mg% (adequate), and 125 mg% pantethine (excess). In the pantethine-deficient and -adequate groups, the contents of fatty acids both in the liver homogenate and in the S-9 fraction were correspondingly decreased by increasing dose levels of AL, and the decrease was remarkable especially in the pantethine-deficient group, but was not significant in the pantethine-excess group even by a high dose of AL. Particularly, in the high dose of AL, the notable decreases of oleic acid (C18:1) contents in both the liver and the S-9 fraction were observed in rats of the pantethine-deficient and -adequate groups. The thiobarbituric acid (TBA) values in the liver homogenate and the S-9 fraction were increased correspondingly by increasing dose levels of AL, and the increases were repressed in the pantethine-excess group.
authors.affiliation: Himeji College of Hyogo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hiramatsu
authors.forename: T
authors.initials: T
authors.lastname: Kishida
authors.forename: T
authors.initials: T
authors.lastname: Hamano
authors.forename: M
authors.initials: M
authors.lastname: Natake
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight; D002849:Chromatography, Gas; D005227:Fatty Acids / Q000737:chemistry; D066298:In Vitro Techniques; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage*; D008099:Liver / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D010204:Pantetheine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D013858:Thiobarbiturates / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D008041:Linoleic Acids; D013858:Thiobarbiturates; D010204:Pantetheine; D008315:Malondialdehyde; C005425:pantethine; D019787:Linoleic Acid; C029684:thiobarbituric acid