title: Propofol as an anaesthetic agent for ECT: effect on outcome and length of course.
abstract: Recent reports of reduced seizure duration with ECT under propofol anaesthesia have led to concerns that propofol may diminish the efficacy of this treatment. To investigate the effect of propofol on the response to ECT, we reviewed records of 66 patients with primary depression treated with ECT, 37 of whom had been assessed prospectively with pre- and post-ECT Hamilton and Zung depression severity ratings. Despite demonstrating that the individual seizure duration was significantly reduced with propofol compared to thiopentone we found no evidence of reduced ECT efficacy with propofol. Courses under propofol anaesthesia were on an average two treatments longer than with thiopentone. Although this difference was not statistically significant this may have been due to a type II error. These results suggest that it is premature to abandon the use of this new anaesthetic agent in ECT without controlled prospective outcome studies.
authors.affiliation: School of Psychiatry, University of New South Wales, Kensington.
authors.forename: P
authors.initials: P
authors.lastname: Mitchell
authors.forename: T
authors.initials: T
authors.lastname: Torda
authors.forename: I
authors.initials: I
authors.lastname: Hickie
authors.forename: C
authors.initials: C
authors.lastname: Burke
mesh_terms: D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D002540:Cerebral Cortex / Q000187:drug effects; D003866:Depressive Disorder / Q000523:psychology / Q000628:therapy*; D004565:Electroconvulsive Therapy; D004569:Electroencephalography / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol; D011569:Psychiatric Status Rating Scales
chemical_list: D015742:Propofol