title: DNA flow cytometry in uterine endometrial carcinoma.
abstract: The DNA content was investigated by means of flow cytometry in frozen tumor specimens from 33 patients with uterine endometrial carcinoma. The association was tested between ploidy and S-phase fraction on one hand and clinico-pathological parameters on the other. Aneuploidy appeared in 15 (45%) of the patients, and the average S-phase fraction was 0.18 (0.04-0.34). There was a highly significant correlation between DNA-Index (DI) and histologic differentiation (p = 0.01) and a less significant correlation between DI and estrogen receptor content (p = 0.04). DNA ploidy measured by flow cytometry is a highly reproducible parameter that in addition to routine histopathological examination may provide useful information. Further studies are needed to establish the prognostic importance of the flow cytometric parameters.
authors.affiliation: Department of Pathology, Aalborg County Hospital, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Jacobsen
authors.forename: M
authors.initials: M
authors.lastname: Høyer
authors.forename: S M
authors.initials: SM
authors.lastname: Bentzen
authors.forename: K
authors.initials: K
authors.lastname: Nielsen
mesh_terms: D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology; D002454:Cell Differentiation; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D011003:Ploidies; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D014594:Uterine Neoplasms / Q000737:chemistry* / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone