Risk factors for stroke as predictors of platelet membrane fluidity in Alzheimer's disease.
We have previously reported that increased platelet membrane fluidity identifies a subgroup of patients with Alzheimer's disease who have distinct clinical features including an earlier age of symptomatic onset, a more rapidly progressive cognitive decline, and a decreased prevalence of focal electroencephalographic findings. In the current study, these patients also exhibited a decreased prevalence of risk factors for stroke compared with patients who had normal platelet membrane fluidity. Our findings suggest that the platelet membrane abnormality describes a clinical subgroup of patients with Alzheimer's disease who are less likely to have coexisting cerebrovascular disease than the remaining patients who meet clinical consensus criteria for probable Alzheimer's disease.
Zubenko
G S
GS
Department of Psychiatry, University of Pittsburgh School of Medicine 15213.
Brenner
R P
RP
Teply
I
I
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000150:complications / Q000401:mortality; D001792:Blood Platelets / Q000502:physiology*; D002545:Brain Ischemia / Q000150:complications; D002561:Cerebrovascular Disorders / Q000209:etiology*; D005544:Forecasting; D006331:Heart Diseases / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D008560:Membrane Fluidity; D012044:Regression Analysis; D012307:Risk Factors; D016019:Survival Analysis