title: Secondary erythrocytosis due to a cerebellar hemangioblastoma: demonstration of erythropoietin mRNA in the tumor.
abstract: Cerebellar hemangioblastoma is a rare cause of secondary erythrocytosis. Although the erythrocytosis is a result of erythropoietin (Ep) stimulation, direct evidence of Ep synthesis by the tumor has been lacking. In an erythrocytotic patient with a cerebellar hemangioblastoma we found elevated levels of Ep in the tumor cyst fluid and for the first time demonstrated Ep mRNA in the tumor by Northern blotting. This finding confirms cerebellar hemangioblastoma as a site of ectopic Ep production.
authors.affiliation: Division of Hematology, McMaster University Medical Centre, Hamilton, Ontario, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Trimble
authors.forename: J
authors.initials: J
authors.lastname: Caro
authors.forename: A
authors.initials: A
authors.lastname: Talalla
authors.forename: M
authors.initials: M
authors.lastname: Brain
mesh_terms: D000328:Adult; D015152:Blotting, Northern; D002528:Cerebellar Neoplasms / Q000097:blood* / Q000235:genetics; D004921:Erythropoietin / Q000032:analysis* / Q000235:genetics*; D006394:Hemangiosarcoma / Q000097:blood* / Q000235:genetics; D006801:Humans; D008297:Male; D011086:Polycythemia / Q000209:etiology* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis* / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D004921:Erythropoietin