[Metachronous nodular leiomyosarcomatosis of peripheral vascular muscle cell in the systemic and regional circulation. A new nosological pattern?].
A patient with five different episodes of single or multiple leiomyosarcomatous nodules in 19 years is described. The nodules were subcutaneous, in the upper lobe of the right lung after 15 years, subcutaneous again after five years and one year later, in the left femoral diaphysis and in the 3rd and 5th abdominal vertebrae two years later. According to the authors, the five different lesions were primary because they were strictly limited to a single organ, they were identical from a histological point of view, no regional glands were affected, and there was no disseminated neoplasia. Finally, the authors emphasize the origin from peripheral vascular muscle cells because of the constant occurrence of peripheral vascular nodules and of signs of vascular muscle cell dysplasia near the neoplastic nodules. They believe to be faced with a new clinical picture which may be defined as: metachronous nodular leiomyosarcoma of peripheral vascular muscle cells in the systemic and lesser circulation.
Gullino
D
D
Service de Chirurgie Générale, Hôpital Départemental SS. Annunziata, Savigliano, Italie.
Giordano
O
O
Abrate
M
M
D000368:Aged; D001775:Blood Circulation; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000145:classification*; D009131:Muscle, Smooth, Vascular; D009135:Muscular Diseases / Q000145:classification*; D009378:Neoplasms, Multiple Primary
Léiomyosarcomatose nodulaire métachrone de la myocellule vasculaire périphérique de la grande et de la petite circulation. Un nouveau cadre nosologique?