[Factors affecting the permeability of cellular and vascular membranes and changes in the enzyme spectrum of the blood in patients having undergone critical states and resuscitation].
126 patients recovered after critical conditions and resuscitation have been examined. Activation of lipid peroxidation and an increase in biogenic amine level, leading to marked hyperenzymemia, have been established. The activity of blood enzyme markers reflecting the severity of brain damage has been studied. It has been established that the more severe encephalopathy, the higher the activity of blood creatine phosphokinase. 2,3-cyclonucleotide-3-phosphohydrolase (CNPH), reflecting the damage of myelin membrane of nervous fibers, has been studied. The appearance of myelin-CNPH marker in the blood confirms demyelinization of the central nervous system (CNS). The more severe encephalopathy, the more marked the process of CNS demyelinization, the higher the activity of CNPH in the blood serum. The highest CNPH activity is observed in patients with eclampsia and in dead patients with postsystolic syndrome.
Novikova
R I
RI
Cherniĭ
V I
VI
Gorodnik
G A
GA
Mareeva
T E
TE
D000293:Adolescent; D000328:Adult; D000368:Aged; D002199:Capillary Permeability / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000502:physiology*; D004798:Enzymes / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D012151:Resuscitation; D013727:Terminal Care
D004798:Enzymes
Issledovanie faktorov, vliiaiushchikh na pronitsaemost' kletochnykh i sosudistykh membran, izmenenie fermentnogo spektra krovi u bol'nykh, perenesshikh kriticheskie sostoianiia i reanimatsiiu.