title: Immunohistochemical study of lepromin reaction in healthy adults.
abstract: Lepromin reaction was studied with immunoperoxidase techniques using monoclonal antibodies. The skin reactions were induced by injecting Mitsuda antigen into healthy adults without a family history of leprosy. Both early (48 hours) and late (3 weeks and 2 months) reactions were examined. In the late reaction, focal collections of epithelioid cells had formed, and not only T- but also B-lymphocytes were observed around the granuloma. CD1a+ cells were also confirmed to have increased in the late reaction.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Miyachi
authors.forename: S
authors.initials: S
authors.lastname: Izumi
authors.forename: H
authors.initials: H
authors.lastname: Ishida
authors.forename: A
authors.initials: A
authors.lastname: Obara
authors.forename: S
authors.initials: S
authors.lastname: Imamura
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D005260:Female; D006099:Granuloma / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007916:Lepromin / Q000494:pharmacology*; D008297:Male; D012867:Skin / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced / Q000473:pathology; D013997:Time Factors
chemical_list: D015703:Antigens, CD; D007916:Lepromin