title: Neutrophil as a mediator of ischemic edema formation in the brain.
abstract: We investigated the contribution of neutrophils to brain edema formation using a transient focal ischemia model in rats. Rats were given anti-neutrophil monoclonal antibody (RP3) intraperitoneally to deplete circulating neutrophils. In RP3-treated rats, ischemic brain edema formation 1 day after reperfusion was significantly decreased compared to that of saline-treated control rats. We speculate that chemical mediators released by infiltrating neutrophils alter vascular permeability and play an important role in post-ischemic brain edema formation.
authors.affiliation: Department of Neurology, Tohoku University, School of Medicine, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shiga
authors.forename: H
authors.initials: H
authors.lastname: Onodera
authors.forename: K
authors.initials: K
authors.lastname: Kogure
authors.forename: Y
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Yashima
authors.forename: H
authors.initials: H
authors.lastname: Syozuhara
authors.forename: F
authors.initials: F
authors.lastname: Sendo
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001834:Body Water / Q000737:chemistry; D001929:Brain Edema / Q000473:pathology / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009504:Neutrophils / Q000473:pathology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D015424:Reperfusion; D013997:Time Factors
chemical_list: D000911:Antibodies, Monoclonal