The reversal of the effects on HMG-CoA reductase activity and microsome lipid composition in chick livers caused by short-period cholesterol feeding.
Chicks of different ages were fed on a cholesterol diet for 48 hours and then switched to a standard diet. HMG-CoA reductase activity and microsomal cholesterol levels, altered by the cholesterol diet, returned to control values in younger chicks after 48 hours on the standard diet. This study clearly shows that early age is an important factor to be taken into account when considering the reversibility of cholesterol-induced membrane alterations.
Alejandre
M J
MJ
Department of Biochemistry & Molecular Biology, University of Granada, Spain.
Garcia-González
M
M
Segovia
J L
JL
D000818:Animals; D002645:Chickens; D002784:Cholesterol / Q000008:administration & dosage*; D004032:Diet; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D008055:Lipids / Q000032:analysis*; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D010743:Phospholipids / Q000032:analysis
D008055:Lipids; D010743:Phospholipids; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases