Effect of solcoseryl on antitumour action and acute toxicity of some antineoplastic drugs.
The in vivo effect of Solcoseryl on the antitumour activity and acute toxicity of some antineoplastic drugs was examined. It was found that Solcoseryl does not inhibit the antineoplastic effectiveness of the drugs against transplantable P 388 leukaemia in mice. Studies of the effect of Solcoseryl on acute toxicity of selected antineoplastic drugs in mice revealed that the biostimulator could exert a modifying influence. The prior administration of Solcoseryl significantly decreases the acute toxicity of methotrexate but has no effect on acute toxicity of 5-fluorouracil, increases the acute toxicity of bleomycin and vinblastine and has no effect on acute toxicity of methotrexate and mitoxantron. On the other hand, Solcoseryl administered simultaneously with the antineoplastic drugs increases acute toxicity of 5-fluorouracil, bleomycin and mitoxantron. The protective effect of the biostimulator noted exclusively against acute toxicity of 5-fluorouracil was also observed after multiple administration of this anticancer drug.
Danysz
A
A
Department of Pharmacology, Institute of Drug Research and Control, Warsaw, Poland.
Sołtysiak-Pawluczuk
D
D
Czyzewska-Szafran
H
H
Jedrych
A
A
Jastrzebski
Z
Z
D000183:Actihaemyl / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use / Q000633:toxicity*; D003561:Cytarabine / Q000627:therapeutic use / Q000633:toxicity; D004347:Drug Interactions; D005472:Fluorouracil / Q000627:therapeutic use / Q000633:toxicity; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D007941:Leukemia P388 / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D008811:Mice, Inbred DBA; D008942:Mitoxantrone / Q000627:therapeutic use / Q000633:toxicity
D000970:Antineoplastic Agents; D003561:Cytarabine; D000183:Actihaemyl; D008942:Mitoxantrone; D005472:Fluorouracil; D008727:Methotrexate