title: Neurotoxicological effects of a pyrethroid formulation, fenvalerate in rats.
abstract: The effect of systemic treatment of a synthetic pyrethroid insecticide, fenvalerate (FV) was examined in adult female rats at different doses i.e. 5, 10, 20 mg/kg body weight by gavage for 21 consecutive days on regional brain levels of noradrenaline (NA), dopamine (DA), their acid metabolites: dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) by HPLC-EC system. Our results demonstrate pronounced inhibition of NA, DA, HVA & DOPAC levels in several brain regions which were neither dose related nor region specific.
authors.affiliation: Industrial Toxicology Research Centre, Lucknow, India.
authors.forename: R
authors.initials: R
authors.lastname: Husain
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: V K
authors.initials: VK
authors.lastname: Khanna
authors.forename: P K
authors.initials: PK
authors.lastname: Seth
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000032:analysis; D005260:Female; D009570:Nitriles; D011722:Pyrethrins / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002395:Catecholamines; D009570:Nitriles; D011722:Pyrethrins; C017690:fenvalerate