title: Comparison of the effects of intraocular irrigating solutions on the corneal endothelium in intraocular lens implantation.
abstract: We conducted a randomised prospective controlled study to determine the effects of a glucose glutathione bicarbonate solution (BSS Plus) and a citrate acetate bicarbonate solution (S-MA2) on the corneal endothelium in patients undergoing extracapsular cataract extraction with posterior chamber lens implantation. One eye of each patient was randomly assigned to receive BSS Plus, and the other eye to receive S-MA2. BSS Plus caused significantly less corneal swelling on the first postoperative day than did S-MA2. There was no difference between the two solutions in their effect on corneal thickness one week and one month postoperatively. Computer assisted morphometric analysis of wide-field specular microscopic photographs demonstrated minimal changes in endothelial morphological characteristics in the eyes irrigated with BSS Plus. By comparison S-MA2, caused a significant loss of endothelial cells and a marked reduction in the figure coefficient. These results indicated that BSS Plus has a clinical advantage over S-MA2 with respect to the corneal endothelium.
authors.affiliation: Department of Ophthalmology, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.forename: S
authors.initials: S
authors.lastname: Kinoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Y
authors.initials: Y
authors.lastname: Shimomura
authors.forename: N
authors.initials: N
authors.lastname: Ohguro
authors.forename: H
authors.initials: H
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Omoto
authors.forename: H
authors.initials: H
authors.lastname: Hosotani
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001639:Bicarbonates / Q000627:therapeutic use; D002452:Cell Count; D015715:Corneal Edema / Q000517:prevention & control; D004338:Drug Combinations; D004728:Endothelium, Corneal / Q000166:cytology / Q000187:drug effects*; D005978:Glutathione / Q000627:therapeutic use; D006801:Humans; D007910:Lenses, Intraocular; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D001639:Bicarbonates; D004338:Drug Combinations; D009883:Ophthalmic Solutions; C013003:glutathione-bicarbonate-Ringer solution; D005978:Glutathione