title: Imedeen for the treatment of degenerated skin in females.
abstract: Imedeen, a new compound for oral administration consisting of special protein fractions and some glucosaminoglycans extracted from marine fish, has been shown in previous pilot studies to have a repairing effect on sun-damaged skin. In an open study, 10 females with sun-damaged skin, aged 39-61 years, were treated with 0.5 g/day Imedeen for 90 days. At baseline and after 30, 60 and 90 days, the following parameters were clinically evaluated: wrinkles; mottles; dryness of skin; and brittleness of hair and nails. After 90 days' treatment all signs of sun-damage had improved and brittleness of hair and nails was normalized in all cases. These clinical observations were confirmed by changes in skin thickness and elasticity. In a second double-blind study, 30 females in the same age range and with similar signs of sun-damage were treated with 0.5 g/day Imedeen or placebo for 90 days. The results in the Imedeen-treated group corresponded to those in the first study whereas no response to treatment was observed in the placebo treatment group.
authors.affiliation: Department of Dermatology, University Central Hospital, Helsinki, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Lassus
authors.forename: L
authors.initials: L
authors.lastname: Jeskanen
authors.forename: H P
authors.initials: HP
authors.lastname: Happonen
authors.forename: J
authors.initials: J
authors.lastname: Santalahti
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004311:Double-Blind Method; D004547:Elastic Tissue / Q000528:radiation effects; D005260:Female; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000627:therapeutic use*; D006201:Hair Diseases / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D009260:Nail Diseases / Q000188:drug therapy; D010865:Pilot Projects; D011506:Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D012867:Skin / Q000293:injuries / Q000528:radiation effects*; D015595:Skin Aging / Q000187:drug effects; D012871:Skin Diseases / Q000188:drug therapy*; D013472:Sunlight / Q000009:adverse effects*
chemical_list: D006025:Glycosaminoglycans; C070172:Imedeen; D011506:Proteins