title: [Evaluation of the possibility of selection of individual anti-arrhythmia therapy].
abstract: Antiarrhythmic therapy was chosen for 3-7 days by modified chronic electrophysiological study at three stages: (1) the efficacy of a drug, its action onset and termination were defined; (2) a dosage was chosen on an individual basis and the duration of drug potency was specified; (3) the dosage regimen of a drug given as a course therapy was confirmed by the results of trials. Its choice was made on the basis of the oral administration of a tested drug and multiple programmed electric cardiostimulation. In late periods (3-37 months), the therapy was effective and safe in 51 (86%) of 59 patients. The drug regimens and doses were in poor agreement with conventional ones in 49% of the patients. The method proposed makes it possible to choose antiarrhythmic therapy on an individual basis and reduce the number of complications.
authors.forename: I V
authors.initials: IV
authors.lastname: Antonchenko
authors.forename: E O
authors.initials: EO
authors.lastname: Gimrikh
authors.forename: S V
authors.initials: SV
authors.lastname: Popov
authors.forename: A M
authors.initials: AM
authors.lastname: Chekhov
authors.forename: E V
authors.initials: EV
authors.lastname: Borisova
authors.forename: G M
authors.initials: GM
authors.lastname: Savenkova
authors.forename: I G
authors.initials: IG
authors.lastname: Plekhanov
mesh_terms: D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D004206:Disopyramide / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D010640:Phenothiazines / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage*; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000188:drug therapy*; D014700:Verapamil / Q000008:administration & dosage*
chemical_list: D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D011433:Propranolol; D014700:Verapamil; C046818:ethacizine; D004206:Disopyramide
vernacular_title: Otsenka vozmozhnosti individual'nogo podbora antiaritmicheskoĭ terapii.