Renal effects of iopentol and iohexol after intravenous injection.
Renal effects of the 2 non-ionic contrast media iopentol and iohexol were investigated and compared in a double-blind, randomized parallel study where 30 patients received iopentol, and 31 patients iohexol intravenously for abdominal CT. The dosage of contrast medium (350 mg I/ml) was 700 mg I/kg body weight. Only one patient (in the iohexol group) had an increase in serum creatinine of more than 50%. Iopentol and iohexol had no effects on the mean serum values of creatinine, urea, and beta 2-microglobulin (beta 2-MG) nor on creatinine clearance. The urinary excretion of albumin and beta 2-MG was also unchanged. The excretion of the proximal tubular enzymes alkaline phosphatase and N-acetyl-beta-glucosaminidase was increased. No significant difference between iopentol and iohexol was found.
Jakobsen
J A
JA
Department of Radiology, National Hospital, Oslo, Norway.
Kolbenstvedt
A N
AN
Berg
K J
KJ
D000117:Acetylglucosamine / Q000652:urine; D000328:Adult; D000368:Aged; D000419:Albuminuria; D000469:Alkaline Phosphatase / Q000652:urine; D003287:Contrast Media; D003404:Creatinine / Q000097:blood / Q000652:urine; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D014283:Triiodobenzoic Acids / Q000008:administration & dosage*; D014508:Urea / Q000097:blood; D001613:beta 2-Microglobulin / Q000032:analysis / Q000652:urine
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D001613:beta 2-Microglobulin; D007472:Iohexol; C053571:iopentol; D014508:Urea; D003404:Creatinine; D000469:Alkaline Phosphatase; D000117:Acetylglucosamine