title: Fluvirucins A1, A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza A virus. II. Structure determination.
abstract: A series of structurally related antiviral antibiotics, fluvirucins A1, A2, B1, B2, B3, B4 and B5 have been isolated from the fermentation broths of five unidentified actinomycete isolates. Based on spectroscopic analysis, partial degradation experiments and 13C-enriched acetic acid-fed biosynthetic studies, their structures were elucidated to be 2.6,10-trialkyl-3(or 9)-aminoglycosyl-13-tridecanelactams.
authors.affiliation: Bristol-Myers Squibb Research Institute, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Naruse
authors.forename: T
authors.initials: T
authors.lastname: Tsuno
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: T
authors.initials: T
authors.lastname: Oki
mesh_terms: D000107:Acetylation; D000192:Actinomycetales / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003837:Deoxy Sugars / Q000737:chemistry* / Q000494:pharmacology; D009980:Influenza A virus / Q000187:drug effects*; D007769:Lactams / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D003837:Deoxy Sugars; D007769:Lactams