Base-pairing models to account for the mutagenicity and specificity of the purine analog 2-amino-N6-hydroxyadenine.
Potential base-pairing mechanisms of the purine analog, 2-amino-N6-hydroxyadenine (AHA), with the natural bases of DNA are presented. Base-pairing properties of this analog indicate that AHA may induce transitions and transversions of base pairs in DNA.
Janion
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Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw.
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D004249:DNA Damage; D006860:Hydrogen Bonding; D009153:Mutagens; D013329:Structure-Activity Relationship
D009153:Mutagens; C030632:2-amino-N(6)-hydroxyadenine; D000225:Adenine