title: IgA nephropathy in non-cirrhotic portal hypertension.
abstract: Renal glomerular changes are a well recognised complication of cirrhosis and are frequently characterised by mesangial IgA deposition. We report a patient with non-cirrhotic portal hypertension who developed IgA nephropathy and a nephrotic syndrome with renal histological changes classically associated with cirrhosis. Splenectomy with resection of a splenic artery aneurysm resulted in remission of the nephrotic syndrome. This case illustrates the factors which contribute to the pathogenesis of IgA nephropathy in liver disease.
authors.affiliation: University Department of Gastroenterology Manchester Royal Infirmary.
authors.forename: C
authors.initials: C
authors.lastname: Babbs
authors.forename: T W
authors.initials: TW
authors.lastname: Warnes
authors.forename: H B
authors.initials: HB
authors.lastname: Torrance
authors.forename: F W
authors.initials: FW
authors.lastname: Ballardie
mesh_terms: D000783:Aneurysm / Q000150:complications / Q000601:surgery; D002675:Child, Preschool; D005922:Glomerulonephritis, IGA / Q000209:etiology* / Q000473:pathology; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D008103:Liver Cirrhosis / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000473:pathology; D013156:Splenectomy; D013157:Splenic Artery