title: Biopharmaceutical evaluation of a tablet dosage form made from ethyl cellulose encapsulated aspirin particles.
abstract: Ethyl cellulose encapsulated aspirin particles, suitable for preparation of direct compression tablets were prepared by the solvent evaporation method. Ethyl acetate was used as a solvent for the polymer in combination with a saturated solution of aspirin as the dispersing medium to prevent partitioning and drug loss. This resulted in a high yield of free-flowing, non-aggregated particles. In vitro-in vivo evaluations of the experimental aspirin tablets (made by direct compression of ethyl cellulose encapsulated particles) and three different commercial aspirin products (a conventional tablet, a timed-release tablet, and a timed-release caplet) were undertaken. Comparison of the dissolution in acidic media at pH 1.2 showed different release profiles for these products. While the conventional tablet and the timed-release caplet showed the highest and the lowest rate of release, respectively; the timed-release tablet and the experimentally made tablet revealed an intermediate rate and very similar release profiles. The cumulative urinary excretion data collected in a complete crossover study, using five healthy subjects further indicated that the experimental tablet has an in vivo availability identical to that of the timed-release tablet.
authors.affiliation: School of Pharmacy, University of Isfahan.
authors.forename: H
authors.initials: H
authors.lastname: Zia
authors.forename: M
authors.initials: M
authors.lastname: Falamarzian
authors.forename: A
authors.initials: A
authors.lastname: Raisi
authors.forename: H
authors.initials: H
authors.lastname: Montaseri
authors.forename: T E
authors.initials: TE
authors.lastname: Needham
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004339:Drug Compounding; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D013607:Tablets
chemical_list: D013607:Tablets; C013517:ethyl cellulose; D002482:Cellulose; D001241:Aspirin