title: Amino acid composition of human liver mitochondrial membranes in normal and pathological conditions.
abstract: The amino acid composition of proteins from liver mitochondrial membranes has been studied in patients with normal liver, with biliary diseases and fatty liver, with obstructive jaundice or liver cirrhosis. A characteristic pattern of the amino acid composition in patients with normal liver has been found. In the mitochondrial membranes of patients with fatty liver tryptophan and lysine were decreased while [aspartic acid plus asparagine] and [glutamic acid plus glutamine] were increased compared to their counterpart in the normal liver. In patients with obstructive jaundice of short duration (less than two months) only a slight decrease in methionine content was found, while in the case of liver cirrhosis amino acid composition was markedly changed.
authors.affiliation: Department of Cell and Molecular Biology, University of Medicine and Pharmacy Cluj-Napoca.
authors.forename: G
authors.initials: G
authors.lastname: Benga
authors.forename: A
authors.initials: A
authors.lastname: Hodârnău
authors.forename: R
authors.initials: R
authors.lastname: Tilinca
authors.forename: V
authors.initials: V
authors.lastname: Borza
authors.forename: W
authors.initials: W
authors.lastname: Ferdinand
mesh_terms: D000596:Amino Acids / Q000032:analysis*; D001660:Biliary Tract Diseases / Q000378:metabolism*; D005591:Chemical Fractionation; D002779:Cholestasis / Q000378:metabolism; D005234:Fatty Liver / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000737:chemistry*; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D008103:Liver Cirrhosis / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000596:Amino Acids; D008055:Lipids