Diagnostic evaluation of 111In and 99mTc radiolabelled monoclonal antibodies in ovarian and colorectal cancer: correlations with surgery.
The results of radioimmunoscintigraphy, RIS, in colorectal and gynaecological cancers were related to the surgical findings and the analysis of the surgical specimens. The improvement in the accuracy of RIS with the progression from 111In through 123I to 99mTc as radiolabel is demonstrated. The convenience, low cost and low radiation dose of 99mTc-labelled antibodies brings the technique of RIS into routine use in the management of patients with these cancers.
Granowska
M
M
Department of Nuclear Medicine, St Bartholomew's Hospital, London, England.
Mather
S J
SJ
Britton
K E
KE
D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen / Q000276:immunology; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D008875:Middle Aged; D008969:Molecular Sequence Data; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D011877:Radionuclide Imaging; D013667:Technetium
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D013667:Technetium