title: Localization of human sarcoma with radiolabeled monoclonal antibody--a follow-up report.
abstract: A group of 16 sarcoma patients with suspected advanced disease were studied with a radiolabeled anti-sarcoma monoclonal antibody (mAb 19-24) in an attempt to localize tumor deposits. All 16 patients received 125I-mAb 19-24 and then had external-probe analysis and imaging performed. Confirmation of tumor deposits was done at surgery or by autopsy. Tissues were studied in surgical patients when possible and analyzed for radioactivity, and tumor-to-blood ratios ranged from 0.6 to 36.8. In conjunction with the patients previously studied, probe results had an overall sensitivity of 83.3% and an overall specificity of 100%; scintigraphic results showed an overall sensitivity of 78.9% and an overall specificity of 100%. Radiolabeled mAb 19-24 may be developed into a useful tool for clinical immunodetection of sarcoma deposits.
authors.affiliation: Division of Surgical Oncology, University of Illinois College of Medicine, Chicago 60612.
authors.forename: J A
authors.initials: JA
authors.lastname: Greager
authors.forename: T C
authors.initials: TC
authors.lastname: Chao
authors.forename: J M
authors.initials: JM
authors.lastname: Brown
authors.forename: D G
authors.initials: DG
authors.lastname: Pavel
authors.forename: M J
authors.initials: MJ
authors.lastname: Blend
authors.forename: T K
authors.initials: TK
authors.lastname: Das Gupta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D005500:Follow-Up Studies; D015902:Gamma Cameras; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging / Q000379:methods; D012509:Sarcoma / Q000000981:diagnostic imaging*; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes