Cellular cytotoxic function and potential in acute myelogenous leukaemia.
Twenty-seven adult AML patients (13 with active disease and 14 in complete remission) were investigated for their cellular cytotoxic potential and function. All AML patients, whether with active disease or in complete remission, showed increased percentage of CD3+ lymphocytes expressing the cytotoxicity-linked cytoplasmic serine esterase, suggesting a higher than normal cytotoxic potential. However, when the cytotoxic function in these patients were analysed in terms of the natural killer and lectin-dependent cellular cytotoxicity, all AML patients, whether with active disease or in complete remission, had impaired target cell lytic activity. This paradox of cytotoxicity is most likely due to the immunosuppressive effect of the serum factor elaborated by leukaemia myeloblasts.
Lim
S H
SH
Department of Haematology, University College Hospital, London.
Worman
C P
CP
Jewell
A P
AP
Goldstone
A H
AH
D000328:Adult; D003593:Cytoplasm / Q000201:enzymology; D003602:Cytotoxicity, Immunologic / Q000502:physiology; D004950:Esterases / Q000502:physiology; D006801:Humans; D007694:Killer Cells, Natural / Q000201:enzymology / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000201:enzymology / Q000276:immunology*
D004950:Esterases; C022635:serine esterase