Blood proteins do not promote adherence of coagulase-negative staphylococci to biomaterials.
We studied the effects of in vitro and in vivo coating of catheters with human blood proteins on binding of coagulase-negative staphylococci. Coating resulted in no enhancement of binding. Catheters coated in vitro bound fewer organisms than uncoated catheters. Host proteins do not enhance adherence of coagulase-negative staphylococci to biomaterials.
Muller
E
E
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Takeda
S
S
Goldmann
D A
DA
Pier
G B
GB
D001422:Bacterial Adhesion; D001672:Biocompatible Materials; D001798:Blood Proteins / Q000494:pharmacology*; D003030:Coagulase; D015169:Colony Count, Microbial; D006801:Humans; D066298:In Vitro Techniques; D013212:Staphylococcus epidermidis / Q000201:enzymology / Q000502:physiology*
D001672:Biocompatible Materials; D001798:Blood Proteins; D003030:Coagulase