title: Antimicrobial contact activity of econazole sulfosalicylate.
abstract: The aim of this investigation was to compare the contact action of econazole sulfosalicylate (E-SSA) on mycetes (Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Trichophyton rubrum, T. cutaneum, Pityrosporum sp.), Gram-positive bacteria (Staphylococcus aureus, Streptococcus faecalis) and Gram-negative bacteria (Escherichia coli, Citrobacter freundii) with that exerted by econazole nitrate (E-NIT). The results show E-SSA activity greater than E-NIT (in particular against mycetes and Gram-negative bacteria). The E-SSA contact activity trials illustrated certain properties of this imidazole sulfosolicylate such as: absence of latency time, antimicrobial activity proportional to its concentration, when a high concentration is used, given the limiting influence of pH and ionic strength of the medium. The higher E-SSA contact activity, in relation to E-NIT, can be correlated to its greater lipophylia considering also the lipophylic properties of SSA and the scarce dissociation of E-SSA.
authors.affiliation: Institute of Microbiology, University of Rome La Sapienza, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Simonetti
authors.forename: G
authors.initials: G
authors.lastname: Spignoli
authors.forename: F D
authors.initials: FD
authors.lastname: D'Auria
authors.forename: V
authors.initials: V
authors.lastname: Strippoli
mesh_terms: D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D004464:Econazole / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects
chemical_list: C070439:econazole sulfosalicylate; D004464:Econazole