title: Blood interactions with novel polyurethaneurea hydrogels.
abstract: The influence on blood of polyurethaneurea hydrogels in vitro was investigated based on poly(ethylene oxide). A hydrogel was compared with the regenerated cellulose membrane Cuprophan in terms of complement activation, as determined by measurement of C3a concentration. The hydrogel induced less complement activation and the presence of poly(ethylene oxide) is likely to be beneficial to platelet reactivity. The ability to vary the polymer composition and the solubility of the polymers in organic solvents makes the polyurethaneurea hydrogels strong candidates for composite biomaterials.
authors.affiliation: Bioengineering Unit, University of Strathclyde, Glasgow, UK.
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: S
authors.initials: S
authors.lastname: Sundaram
authors.forename: D
authors.initials: D
authors.lastname: Weng
authors.forename: J M
authors.initials: JM
authors.lastname: Courtney
authors.forename: C R
authors.initials: CR
authors.lastname: Moran
authors.forename: N B
authors.initials: NB
authors.lastname: Graham
mesh_terms: D001672:Biocompatible Materials; D001769:Blood; D001792:Blood Platelets; D002482:Cellulose / Q000031:analogs & derivatives; D003167:Complement Activation; D015926:Complement C3a / Q000032:analysis; D006801:Humans; D008567:Membranes, Artificial; D011092:Polyethylene Glycols; D011140:Polyurethanes; D012016:Reference Values; D012995:Solubility
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011140:Polyurethanes; D011092:Polyethylene Glycols; D015926:Complement C3a; D002482:Cellulose; C009865:cuprammonium cellulose