[Capsaicin-induced mouse ear edema and its management].
Oedema was induced in one ear of male mice of the CFLP strain with capsaicin solution (10 microliters/40 micrograms/ear). The development in time and the extent of the oedema were determined by the oedema-disk gravimetric technique. The maximum oedema was attained after 1 hour, and there was subsequently a gradual decrease. The extent of the mouse ear oedema induced in this way and measured after 60 minutes was inhibited to a statistically significant degree and in a dose-dependent manner by the antihistamine chloropyramine, the antihistamine-antiserotonin cyproheptadine, the non-steroidal antiinflammatory agent pyroxicam, the prostaglandin antagonist di-4-phloretin phosphate, and the lipoxygenase inhibitor nordihydroguaiaretic acid. The method proved suitable for the detection and biologically quantitative determination of the state of desensitization induced with capsaicin.
Gábor
M
M
Szent-Györgyi Albert Orvostudományi Egyetem, Gyógyszerhatástani Intézet, Szeged.
Cseh
G
G
Rázga
Z
Z
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002211:Capsaicin / Q000276:immunology / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology; D006633:Histamine Antagonists / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006633:Histamine Antagonists; D002211:Capsaicin
Kapszaicinnel elöidézett egérfül-ödéma és befolyásolása.