title: Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy.
abstract: BACKGROUND
  The development of a microcomputer-based device permits quick, simple, and noninvasive quantification of the respiratory sinus arrhythmia (RSA) during quiet breathing.
  
  
  RESULTS
  We prospectively and serially measured the radionuclide left ventricular ejection fraction and the RSA amplitude in 34 cancer patients receiving up to nine monthly bolus treatments with doxorubicin hydrochloride (60 mg/m2). Of the eight patients who ultimately developed symptomatic doxorubicin-induced congestive heart failure, seven (87.5%) demonstrated a significant decline in RSA amplitude; five of 26 subjects without clinical symptoms of cardiotoxicity (19.2%) showed a similar RSA amplitude decline. On average, significant RSA amplitude decline occurred 3 months before the last planned doxorubicin dose in patients destined to develop clinical congestive heart failure.
  
  
  CONCLUSIONS
  Overall, RSA amplitude abnormality proved to be a more specific predictor of clinically significant congestive heart failure than did serial resting radionuclide ejection fractions.
authors.affiliation: Department of Medicine (Medical Oncology), Albany Medical College, NY.
authors.forename: W J
authors.initials: WJ
authors.lastname: Hrushesky
authors.forename: D J
authors.initials: DJ
authors.lastname: Fader
authors.forename: J S
authors.initials: JS
authors.lastname: Berestka
authors.forename: M
authors.initials: M
authors.lastname: Sommer
authors.forename: J
authors.initials: J
authors.lastname: Hayes
authors.forename: F O
authors.initials: FO
authors.lastname: Cope
mesh_terms: D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000139:chemically induced*; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D005544:Forecasting; D006333:Heart Failure / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D012849:Sinoatrial Node / Q000502:physiology*; D013318:Stroke Volume / Q000187:drug effects; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D004317:Doxorubicin