title: [Characteristics of the changes in the concentration of 2,3-diphosphoglycerate in heart surgery patients].
abstract: Changes in 2,3-DPG level have been studied in cardiosurgical patients. It has been shown that 2,3-DPG concentration increase, as a moderately fast mechanism in a common model of tissue pO2 regulation, is observed in almost half of patients with acquired heart valve defects. An increase in 2,3-DPG level and P50 value leading to a decrease in hemoglobin affinity to oxygen has been found in one third of patients. It has been established that 2,3-DPG level and P50 value are, as a rule, normal in patients with mitral stenosis, acyanotic congenital heart valve defects and ischemic heart disease. In a number of patients with mitral stenosis an increased Hb concentration, as a slow mechanism of hypoxia compensation in the model of tissue pO2 regulation, is a prevailing mechanism of adaptation to hypoxia.
authors.forename: M N
authors.initials: MN
authors.lastname: Grishchenko
authors.forename: L A
authors.initials: LA
authors.lastname: Mosolova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Andrianova
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003327:Coronary Disease / Q000097:blood*; D004163:Diphosphoglyceric Acids / Q000097:blood*; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012214:Rheumatic Heart Disease / Q000097:blood*
chemical_list: D004163:Diphosphoglyceric Acids
vernacular_title: Osobennosti izmeneniia kontsentratsii 2,3-difosfoglitserata u kardiokhirurgicheskikh bol'nykh.