title: [The effect of the selenium status of goats on the resistance of erythrocytes to oxidative damage].
abstract: The effect of selenium status on the development of Heinz body anaemia was studied in 16 three months old Saanen goats which received a diet with a low selenium content. The control group (Se-, n = 8) received no supplementary selenium while the treated group (Se+, n = 8) received selenium by injection. Erythrocyte glutathione peroxidase concentration was significantly higher in the Se+ group than in the control group (105 vs 36 U/g Hgb). The animals were drenched once per day with 30 mg of dimethyl disulphide (DMDS) per kg of body weight for 14 days and with 50 mg per kg during the following 11 days. Erythrocytes with Heinz bodies appeared within one week after increasing the DMDS dose to 50 mg/kg/day and reached a peak one week later (30% and 37% of erythrocytes with Heinz bodies in group Se+ and Se- respectively). Within the next three weeks haemoglobin levels dropped from 135 g/l to 123 g/l and 114 g/l in the Se+ and the Se- group respectively. Differences between the two groups were statistically significant for the percentage of erythrocytes with Heinz bodies and for haemoglobin values (p less than 0.05). The data support the hypothesis that selenium status influences the resistance of ruminants to brassica-induced Heinz body anaemia.
authors.affiliation: Eidgenössische Forschungsanstalt für viehwirtschaftliche Produktion, Posieux.
authors.forename: A
authors.initials: A
authors.lastname: Gutzwiller
mesh_terms: D000740:Anemia / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D004912:Erythrocytes / Q000473:pathology*; D015511:Goat Diseases / Q000209:etiology*; D006041:Goats; D006366:Heinz Bodies; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D010084:Oxidation-Reduction; D012643:Selenium / Q000008:administration & dosage*
chemical_list: D006454:Hemoglobins; D012643:Selenium
vernacular_title: Einfluss der Selenversorgungslage der Ziege auf die Resistenz der Erythrozyten gegen oxidative Schädigung.