[Protective effect of sheng mai injection on myocardial injury induced by adriamycin in cultured myocardial cells].
The effect of sheng mai injection (SMI) on adriamycin-induced cardiotoxicity in cultured myocardial cells was examined. Adriamycin treatment (1 mg/L) for 4 h of culture age, increased remarkably the leakage of lactate dehydrogenase (LDH) from the myocardial cells, and induced the damage of ultrastructure. SMI (30 mg/L, 100 mg/L, 300 mg/L) had no effects on these changes induced by adriamycin. The results showed that SMI had no direct protective effect on adriamycin cardiotoxicity in cultured myocardial cells. It's protective effect on adriamycin cardiotoxicity seems to be in whole body level, the mechanism of which was relating to the metabolism of the drug in organism, and is worthy of further research.
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Xin-Hua Hospital, Shanghai Second Medical University.
D000818:Animals; D002478:Cells, Cultured; D004317:Doxorubicin; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000473:pathology / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains
D004365:Drugs, Chinese Herbal; D004317:Doxorubicin; D007770:L-Lactate Dehydrogenase