title: Sedation for paediatric computerized tomography--a double-blind assessment of rectal midazolam.
abstract: This double-blind study investigated the rectal administration of midazolam as an alternative to general anaesthesia for elective computerized tomography (CT) of the brain. Thirty children were randomly allocated to receive either midazolam 0.3 mg kg-1 (Group 1) or midazolam 0.6 mg kg-1 (Group 2) by the rectal route. Sedation was obtained in 13 children in Group 1 and 12 in Group 2 but this was only satisfactory for scanning in seven children in Group 1 and eight in Group 2. We concluded that although the technique produced sedation, it did not reliably produce satisfactory conditions for CT scanning.
authors.affiliation: Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom.
authors.forename: D M
authors.initials: DM
authors.lastname: Coventry
authors.forename: C S
authors.initials: CS
authors.lastname: Martin
authors.forename: A M
authors.initials: AM
authors.lastname: Burke
mesh_terms: D000285:Administration, Rectal; D001785:Blood Gas Monitoring, Transcutaneous; D001921:Brain / Q000000981:diagnostic imaging*; D002652:Child Behavior; D002675:Child, Preschool; D016292:Procedural Sedation; D003299:Cooperative Behavior; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007223:Infant; D008874:Midazolam / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D008874:Midazolam