title: Porphyria cutanea tarda associated with human immunodeficiency virus infection. A study of four cases and review of the literature.
abstract: We report the cases of 4 male subjects, 29, 32, 41 and 44 years old, presenting isolated seropositivities for the human immunodeficiency virus (HIV), or full-blown acquired immunodeficiency syndrome, associated with a typical porphyria cutanea tarda (PCT). The 4 patients are in the usual risk groups for HIV infection. Viral hepatitis was observed in 3 of the 4 cases. Over the past 3 years, 15 cases associating HIV infection and PCT have been reported; almost all had the usual risk factors for HIV infection and hepatopathy. We speculate that HIV infection may have favored the occurrence of early PCT in these cases by altering the metabolism of the porphyrins, either directly or by means of the associated hepatopathy.
authors.affiliation: Service de Dermatologie, Hôpital Haut-Lévêque, Bordeaux, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Boisseau
authors.forename: P
authors.initials: P
authors.lastname: Couzigou
authors.forename: J F
authors.initials: JF
authors.lastname: Forestier
authors.forename: V
authors.initials: V
authors.lastname: Legrain
authors.forename: J
authors.initials: J
authors.lastname: Aubertin
authors.forename: M S
authors.initials: MS
authors.lastname: Doutre
authors.forename: J
authors.initials: J
authors.lastname: Maleville
authors.forename: M
authors.initials: M
authors.lastname: Geniaux
authors.forename: C
authors.initials: C
authors.lastname: Beylot
mesh_terms: D000328:Adult; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis; D006679:HIV Seropositivity / Q000175:diagnosis; D006801:Humans; D008297:Male; D011164:Porphyrias / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D011166:Porphyrins / Q000378:metabolism; D012008:Recurrence; D012307:Risk Factors; D012871:Skin Diseases / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D019966:Substance-Related Disorders / Q000150:complications
chemical_list: D011166:Porphyrins