[Induction of autoreactive T-cells by bacterial stress proteins in HLA-DR4 donors].
From the peripheral blood of HLA-DR4+ healthy donors or patients with rheumatoid arthritis autoreactive T-cell lines were obtained after stimulation with bacterial heat-shock protein. All lines obtained express an alpha/beta-T-cell receptor and they are predominantly CD4+. The determination of the fine specificity of those autoreactive T cells showed, that either amino-acid position #71 or #86 of the HLA-DR beta 1 chain was critical for recognition by the antigen receptor.
Epplen
C
C
Max-Planck-Institut für Psychiatrie, Martinsried.
Mitreiter
R
R
Hatz
H
H
Helmke
K
K
Albert
E
E
Epplen
J T
JT
D001782:Blood Donors; D015804:HLA-DR4 Antigen / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D015804:HLA-DR4 Antigen; D006360:Heat-Shock Proteins; D011948:Receptors, Antigen, T-Cell
Induktion autoreaktiver T-Zellen durch bakterielle Stressproteine bei HLA-DR4(+)-Spendern.