Cell kinetics and hormonal features in relation to pathological stage in breast cancer.
Proliferative activity (expressed as 3H-thymidine labeling index, 3H-TdR LI) was evaluated on a series of 281 primary tumors recruited in two years in 6 different institutions from central Italy. 3H-TdR LI proved to be low in intraductal, or well and moderately differentiated, or hormone receptor positive tumors. Conversely, no relation was observed between 3H-TdR LI and menopause, tumor size, or lymph node involvement. An inverse relation was observed between 3H-TdR LI and hormone receptor content. Specific patterns of 3H-TdR LI value and ER content association were observed as a function of menopause, lymph nodal status, and degree of lymph nodal involvement.
Amadori
D
D
Oncology Department, Morgagni-Pierantoni Hospital, U.S.L. 38, Forli, Italy.
Bonaguri
C
C
Nanni
O
O
Gentilini
P
P
Lundi
N
N
Zoli
W
W
Riccobon
A
A
Vio
A
A
Magni
E
E
Saragoni
A
A
D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division; D005260:Female; D006801:Humans; D008593:Menopause / Q000502:physiology; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000096:biosynthesis*; D011980:Receptors, Progesterone / Q000096:biosynthesis*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone