An in vitro study of the possible interaction between human platelets and cephalosporins.
The effects in vitro of four cephalosporins (ceftazidime, cefuroxime, cefotaxime and ceftriaxone) on adenosine diphosphate-induced human platelet aggregation were investigated. Ceftazidime-induced inhibition of platelet aggregation was significant only at a final concentration of 1 mg/ml, whereas ceftriaxone-induced inhibition of platelet aggregation was also significant at a final concentration of 0.01 mg/ml. Cefotaxime and cefuroxime were less active than ceftriaxone.
Cazzola
M
M
Clinical Pharmacology Unit, A. Cardarelli Hospital, Naples, Italy.
Santangelo
G
G
Martucci
P
P
Caputi
M
M
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors
D002511:Cephalosporins; D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate