[Experimental assessment of the effectiveness of modified polyhemoglobin in the model of extreme hemodilution].
The efficacy of the modified polyhemoglobin suggested as an artificial oxygen transporting substitute was estimated in the model of extreme hemodilution in dogs. It was shown that O2 consumption in dogs had been supported on the normal level during 4 hours after total exchange transfusion with the polyhemoglobin solution. Index of hemodynamics testifies that preparation has hemodynamics action. The conclusion was made that this modified polyhemoglobin has been effective O2 carrying blood substitute.
Kolonina
I R
IR
Litvinenko
Iu A
IuA
Sokolov
A V
AV
D000818:Animals; D001802:Blood Substitutes; D004285:Dogs; D005069:Evaluation Studies as Topic; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006438:Hemodilution; D006439:Hemodynamics; D006454:Hemoglobins; D008297:Male; D008954:Models, Biological; D010100:Oxygen / Q000097:blood; D013997:Time Factors
D001802:Blood Substitutes; D006454:Hemoglobins; C037158:polyhemoglobin; D010100:Oxygen
Eksperimental'naia otsenka éffektivnosti modifitsirovannogo poligemoglobina na modeli predel'noĭ gemodiliutsii.