[Left ventricular function in arterial hypertension in relation to age. The short-term effects of nicardipine].
The purpose of this study was to assess the age related effects on left ventricular function after acute administration of the calcium-antagonist nicardipine. Gated radionuclide left ventriculography was performed before and 90 min after 40 mg of oral nicardipine in a group of 15 male patients with essential hypertension (H), 8 younger (HY) and 7 older (HO) than 60 years, and in a control group of 15 male subjects without cardiovascular disease (C), 7 younger (CY) and 8 older (CO) than 60 years. Baseline ejection fraction (EF) was similar in groups H and C, while peak ejection (PER) and peak filling (PFR) rates were lower in hypertensive patients as compared to controls. Baseline EF and PER were similar in subgroups HY and HO as well as in subgroups CY and CO, while PFR was particularly lower in the older hypertensive patients HO. After nicardipine, EF PER PFR significantly increased in groups H and C; EF and PER significantly increased in subgroups HY HO CY CO, while PFR had a significant increase in subgroups HY CY CO, but showed a not significant increase in subgroup HO. After nicardipine, the percentage changes of ventricular volume indexes were similar in the 4 subgroups; end diastolic volume was unchanged, end systolic volume had a clear decrease, stroke volume and cardiac output increased. The hypertensive patients had a damaged diastolic ventricular performance, as compared to the normal subjects, while EF was near to normal range in groups H and C.(ABSTRACT TRUNCATED AT 250 WORDS)
Astorri
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E
Cattedra di Cardiologia, Università di Parma.
D000328:Adult; D000368:Aged; D000375:Aging / Q000187:drug effects* / Q000502:physiology; D004341:Drug Evaluation; D015637:Gated Blood-Pool Imaging; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000627:therapeutic use*; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
D009529:Nicardipine
La funzione ventricolare sinistra nell'ipertensione arteriosa in relazione all'età. Effetti a breve termine della nicardipina.