title: Comparison of glucose-6-phosphate dehydrogenase activity in healthy and atretic follicles in rat ovary.
abstract: Changes in the glucose-6-phosphate dehydrogenase activity have been determined in relation to atresia of Graafian follicles in the rat ovary. Induction of atresia in follicles either due to absence of hCG in the hormonally stimulated immature ovaries or by repeated injections of pentobarbitone sodium to proestrous rats caused significant rise in the enzyme activity. Measurement of enzyme activity in isolated follicular compartments of healthy and atretic follicles revealed that it is significantly higher in the thecal tissue than the granulosa. Increase in enzyme activity in the atretic follicles than the healthy ones occurs due to its rise both in theca and granulosa cells. The significance of these changes in the enzyme activity in healthy and atretic follicles are discussed in relation to the precocious luteinization of cells in the follicular envelope with the onset of atresia.
authors.affiliation: ICMR-Advanced Research Centre on Reproductive Biology, Punjab Agricultural University, Ludhiana, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Parshad
authors.forename: S S
authors.initials: SS
authors.lastname: Guraya
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005260:Female; D005496:Follicular Atresia / Q000502:physiology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006064:Gonadotropins, Equine / Q000494:pharmacology; D006080:Ovarian Follicle / Q000187:drug effects / Q000201:enzymology*; D051381:Rats
chemical_list: D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D005954:Glucosephosphate Dehydrogenase