title: Radioprotective effect of dextran sulphate and aerogenic hypoxia on intestinal crypt stem cells in mice.
abstract: A single intraperitoneal injection of dextran sulphate given 6 h before irradiation produced higher numbers of microcolonies of intestinal crypt stem cells in whole-body irradiated mice than injection of saline in control mice. If dextran sulphate and hypoxia are combined, the radioprotective effect of hypoxia on intestinal crypt stem cells depends on the time interval between irradiation and administration of dextran sulphate.
authors.affiliation: Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
authors.forename: A
authors.initials: A
authors.lastname: Vacek
authors.forename: O A
authors.initials: OA
authors.lastname: Konoplyanikova
authors.forename: A G
authors.initials: AG
authors.lastname: Konoplyanikov
authors.forename: A
authors.initials: A
authors.lastname: Bartonícková
authors.forename: D
authors.initials: D
authors.lastname: Rotkovská
mesh_terms: D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology*; D016264:Dextran Sulfate / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007413:Intestinal Mucosa / Q000166:cytology* / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013234:Stem Cells / Q000187:drug effects / Q000528:radiation effects*; D014916:Whole-Body Irradiation
chemical_list: D011837:Radiation-Protective Agents; D016264:Dextran Sulfate