The effect of vitamin C intake on plasma oxalate in patients on regular haemodialysis.
Plasma oxalate was measured on two occasions in 18 patients with end-stage renal failure on regular haemodialysis treatment: once while on a routine dose of vitamin C (100 mg/day) and subsequently after 2 weeks administration of a larger dose of vitamin C (500 mg/day). Pre- and post-dialysis concentrations were all markedly increased, reflecting the reduced glomerular filtration rate of end-stage renal failure. Both pre- and post-dialysis oxalate increased significantly following the increase in ascorbate dose but there was no significant correlation between plasma oxalate and ascorbate results. Considerations governing dosage of vitamin C in patients with chronic renal failure are discussed.
Rolton
H A
HA
Department of Biochemistry, Stobhill General Hospital, Glasgow, UK.
McConnell
K M
KM
Modi
K S
KS
Macdougall
A I
AI
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010070:Oxalates / Q000097:blood*; D019815:Oxalic Acid; D006435:Renal Dialysis
D010070:Oxalates; D019815:Oxalic Acid; D003404:Creatinine; D001205:Ascorbic Acid