Binding of the BL/VL3 murine T cell lymphoma to radiation leukaemia virus is specific for viral env determinants.
Molecularly cloned radiation leukaemia viruses (RadLVs) isolated from the BL/VL3 radiation-induced thymoma have been used in assays to compare the binding specificity of the BL/VL3 cell line for different retroviruses. BL/VL3 cells bound well to two of three thymotropic, leukaemogenic viruses produced by this cell line. BL/VL3 did not bind to a cloned fibrotropic, non-leukaemogenic RadLV. BL/VL3 appears to have receptor specificity for only some of the leukaemogenic RadLVs, and this appears to be related to differences in the viral env sequence.
O'Neill
H C
HC
Developmental Haematology Group, John Curtin School of Medical Research, Australian National University, Canberra.
D000818:Animals; D003001:Cloning, Molecular; D004591:Electrophoresis, Polyacrylamide Gel; D015686:Gene Products, env / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000378:metabolism / Q000382:microbiology*; D015183:Restriction Mapping; D012190:Retroviridae / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity; D014407:Tumor Cells, Cultured; D014771:Virion / Q000235:genetics / Q000378:metabolism*
D015686:Gene Products, env