title: Hyporegenerative anemia associated with intrauterine transfusion in rhesus hemolytic disease.
abstract: Serial erythropoietin and ferritin levels were monitored in a fetus and newborn requiring three intravascular transfusions (in utero) for severe Rh disease. The newborn had a hematocrit of 37% at birth; however a hyporegenerative transfusion-dependent anemia developed and lasted approximately 3 months. The prolonged hyporegenerative anemia may be caused in part by erythropoietin suppression as a result of the fetal intravascular transfusions. In addition, anti-D antibody may also contribute to this anemia by a direct toxic effect on erythroid precursors and by peripheral hemolysis of reticulocytes.
authors.affiliation: St. Luke's Perinatal Center, St. Luke's Hospital, Kansas City, MO 64111.
authors.forename: J A
authors.initials: JA
authors.lastname: Thorp
authors.forename: T
authors.initials: T
authors.lastname: O'Connor
authors.forename: J
authors.initials: J
authors.lastname: Callenbach
authors.forename: G R
authors.initials: GR
authors.lastname: Cohen
authors.forename: J D
authors.initials: JD
authors.lastname: Yeast
authors.forename: J
authors.initials: J
authors.lastname: Albin
authors.forename: F
authors.initials: F
authors.lastname: Plapp
mesh_terms: D000328:Adult; D000740:Anemia / Q000097:blood / Q000209:etiology* / Q000628:therapy; D001803:Blood Transfusion; D001805:Blood Transfusion, Intrauterine / Q000009:adverse effects*; D002452:Cell Count; D004899:Erythroblastosis, Fetal / Q000628:therapy*; D004921:Erythropoietin / Q000032:analysis; D005260:Female; D006400:Hematocrit; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D012156:Reticulocytes / Q000473:pathology
chemical_list: D004921:Erythropoietin