title: Premixed insulin at ratio 3/7 and regular + isophane insulins at mixing ratios from 2/8 to 4/6 achieve the same metabolic control.
abstract: The insulin regimen with two daily injections is still that more frequently used. Often regular and NPH insulins are mixed at different ratios according to the patient's need; however, the mixture preparation can involve several errors. Efficacy, safety and compliance were evaluated comparing a premixture 3/7 (Actraphane HM) with extemporary mixtures of regular + NPH at mixing ratios ranging from 2/8 to 4/6, in a cross-over study of 8 weeks involving 20 insulin dependent diabetics. Metabolic control, hypoglycaemic episodes, insulin dose and proportions were similar with both treatments while a higher compliance was achieved with the premixture. In conclusion, premixture 3/7 and extemporary mixture (from 2/8 to 4/6) obtain the same efficacy and safety but the former shows a higher acceptability.
authors.affiliation: Istituto di Medicina Interna, Università di Messina, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Cucinotta
authors.forename: D
authors.initials: D
authors.lastname: Mannino
authors.forename: A
authors.initials: A
authors.lastname: Lasco
authors.forename: E
authors.initials: E
authors.lastname: Di Cesare
authors.forename: C
authors.initials: C
authors.lastname: Musolino
authors.forename: R
authors.initials: R
authors.lastname: Alessi
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D007336:Insulin, Isophane / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D006595:Hexosamines; D007328:Insulin; D019270:Fructosamine; D007336:Insulin, Isophane