title: The action of trenbolone acetate, a synthetic anabolic steroid, on ovarian function in the guinea pig.
abstract: The action of trenbolone acetate, a synthetic anabolic steroid, on ovarian function was investigated in the guinea pig. Certain comparisons were made with testosterone, the naturally occurring androgen, administered as the phenylpropionate ester. Two milligrams trenbolone acetate per kg given subcutaneously on alternate days for 20 days blocked oestrous cyclicity and ovulation in 9 of 10 animals. A similar effect was shown by 2.2 mg of testosterone phenylpropionate. Treatment of trenbolone acetate-treated animals with exogenous gonadotrophins suggested that the production of follicle-stimulating hormone had been suppressed. Signs of abnormality were seen in the livers of animals receiving 2 mg trenbolone acetate and 2.2 mg testosterone phenylpropionate.
authors.affiliation: Department of Agriculture, University of Aberdeen, UK.
authors.forename: M
authors.initials: M
authors.lastname: Zarkawi
authors.forename: H
authors.initials: H
authors.lastname: Galbraith
authors.forename: J S
authors.initials: JS
authors.lastname: Hutchinson
mesh_terms: D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D003338:Corpus Luteum / Q000166:cytology / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects / Q000473:pathology; D006080:Ovarian Follicle / Q000166:cytology / Q000187:drug effects; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D010060:Ovulation; D011374:Progesterone / Q000032:analysis / Q000097:blood; D012016:Reference Values; D013739:Testosterone / Q000494:pharmacology; D014204:Trenbolone Acetate / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D045930:Anabolic Agents; D013739:Testosterone; D011374:Progesterone; D014204:Trenbolone Acetate