The effect of glycerol on short-term experimental endolymphatic hydrops.
The aim of this paper was to evaluate the effect of one month of treatment with different dosages of glycerol on experimental endolymphatic hydrops produced by obliteration of endolymphatic sac and duct through an extradural approach. Forty-two guinea pigs were used. The animals, divided into six groups, received 0.5-2 gr/kg body weight of the drug per day for one month. The activity of glycerol was determined by statistical analysis of volumetric changes of scala media. Glycerol demonstrated the effect of reducing endolymphatic hydrops. The decrease in hydrops was influenced by the dosage suggesting a stria metabolic response.
Magliulo
G
G
ENT Department, University La Sapienza, Rome, Italy.
Della Rocca
C
C
Ungari
C
C
Muscatello
M
M
D000284:Administration, Oral; D000818:Animals; D003051:Cochlea / Q000187:drug effects / Q000473:pathology; D003053:Cochlear Duct / Q000187:drug effects / Q000473:pathology; D004487:Edema / Q000188:drug therapy* / Q000473:pathology; D004711:Endolymphatic Duct / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005990:Glycerol / Q000008:administration & dosage / Q000627:therapeutic use*; D006168:Guinea Pigs; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy* / Q000473:pathology; D012533:Scala Tympani / Q000187:drug effects / Q000473:pathology; D013136:Spiral Ganglion / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D015837:Vestibular Diseases / Q000188:drug therapy / Q000473:pathology
D005990:Glycerol