title: [Pathogenesis of homeometric and heterometric autoregulation of the heart in mitral valve defects].
abstract: Right ventricular (RV) function was investigated using rheopulmonography at Valsalva's manoeuvre and echocardiography in 36 patients with rheumatic heart disease which were divided into three groups: with RV normal-size chamber and normal thickness of the wall (I), with normal-size RV chamber and myocardial hypertrophy (II), with RV dilatation and hypertrophy. In patients of group I there appeared mitral stenosis of degree I (Gorlin) and insignificant elevation of pressure in the pulmonary artery. Mitral defect was compensated through the mechanism "stress-mobilization" underlying homeometric autoregulation of the heart. As a result, muscular thickness grows without hypertrophy and becomes stronger. In more pronounced narrowing of mitral opening (group II) the second stage of the compensation comes: in latent pulmonary hypertension hypertrophy develops as a prolonged adaptation to greater load. Hypertrophic myocardium is the most resistant to overloading with external pressure. In group III patients with mitral narrowing degree 2 and more distinct pulmonary hypertension one can observe an addition of Frank--Starling mechanism--heterometric type of autoregulation. In spite of its triggering compensation of the defect remains insufficient (circulation deficiency becomes clear-cut in patients of group III).
authors.forename: O V
authors.initials: OV
authors.lastname: Riazantseva
authors.forename: I I
authors.initials: II
authors.lastname: Sivkov
authors.forename: N S
authors.initials: NS
authors.lastname: Chebyshev
authors.forename: Iu Ia
authors.initials: IuIa
authors.lastname: Demchenkov
mesh_terms: D000328:Adult; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000503:physiopathology*; D008946:Mitral Valve Stenosis / Q000503:physiopathology*; D012016:Reference Values; D014636:Valsalva Maneuver; D016278:Ventricular Function, Right / Q000502:physiology
vernacular_title: O patogeneze gomeometricheskoĭ i geterometricheskoĭ autoreguliatsii serdtsa pri mitral'nykh porokakh.