title: Evaluation of a theoretical Doppler index to noninvasively estimate peak dP/dt using continuous wave Doppler ultrasound of ascending aortic flow in man.
abstract: A theoretical formula for calculation of peak dP/dt was derived using parameters obtained from continuous wave Doppler echocardiography signals of aortic blood flow. The direct proportional relationship between the main variables of this formula and invasively measured peak dP/dt was validated in 20 patients undergoing routine diagnostic cardiac catheterization. Doppler signals of aortic flow were obtained simultaneously to invasive pressure recordings with a 2 MHz continuous wave transducer via the suprasternal echocardiographic window. The Doppler signals were recorded on magnetic tape and measurements were made with digital calipers by two independent, blinded observers. The following parameters were measured: peak velocity (V) and time from onset of ejection to peak velocity (T). V2/T, the variable of the derived formula, was calculated for each of the observer's measured parameters and showed a very high interobserver correlation. The two observers' measurements of each parameter were averaged for each patient and the resulting mean was used in calculating the V2/T and mean acceleration. 4. A good correlation of V2/T with invasively measured peak dP/dt was obtained. Our derived index of left ventricular function showed a higher correlation with peak dP/dt compared to other Doppler indices of ventricular function. V2/T may provide a noninvasive method for estimating peak dP/dt.
authors.affiliation: University Department of Cardiovascular Medicine, Queen Elizabeth Hospital, University of Birmingham, England, UK.
authors.forename: A C
authors.initials: AC
authors.lastname: Hunt
authors.forename: S L
authors.initials: SL
authors.lastname: Chow
authors.forename: J
authors.initials: J
authors.lastname: Escaned
authors.forename: R A
authors.initials: RA
authors.lastname: Perry
authors.forename: A
authors.initials: A
authors.lastname: Seth
authors.forename: M F
authors.initials: MF
authors.lastname: Shiu
mesh_terms: D001011:Aorta / Q000000981:diagnostic imaging* / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology; D006328:Cardiac Catheterization; D015150:Echocardiography, Doppler / Q000379:methods*; D005069:Evaluation Studies as Topic; D006801:Humans; D008297:Male; D015588:Observer Variation; D012044:Regression Analysis; D016277:Ventricular Function, Left / Q000502:physiology*