[Study of the status of energy metabolism in thyrotoxicosis by the insulin test].
The insulin test was carried out in 68 healthy subjects and 20 patients with moderate thyrotoxicosis at the stage of compensation. Blood levels of pyruvate and lactate, plasma and erythrocytic glucose, urinary catecholamines and gas exchange were measured before, 30 and 120 min after intravenous administration of insulin (0.15 U/kg). All the measurements evidenced hypermetabolism: oxygen consumption, carbonic acid production, pulmonary ventilation were enhanced; lactate-pyruvate index and urine catecholamines were lower versus those of healthy subjects. Correlation analysis demonstrated disturbed regulation of hyperventilation by the sympathetic-adrenal system in thyrotoxicosis.
Sokolov
E I
EI
Zaev
A P
AP
Khovanskaia
T P
TP
Razin
A S
AS
Zhizhina
S A
SA
Morozova
T P
TP
Velichkina
S V
SV
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002395:Catecholamines / Q000652:urine; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006019:Glycolysis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D013971:Thyrotoxicosis / Q000378:metabolism*
D001786:Blood Glucose; D002395:Catecholamines; D007328:Insulin; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid
Sostoianie énergeticheskogo obmena pri tireotoksikoze po dannym insulinovoĭ proby.