title: Influence of vegetable oil vehicles on bone-marrow proliferation in the mouse micronucleus test.
abstract: The detection of genotoxins in the mouse bone-marrow micronucleus (MN) test is sensitive to factors which may inhibit bone-marrow proliferation. We have shown that three commercially available cooking oils (olive, peanut and sunflower seed oils), commonly used as vehicles in toxicological tests, were able to induce a cytotoxic effect in mouse bone marrow. The effects observed were reversible and the magnitude of the responses varied with the oil administered. The results suggest a need to examine vehicle effects when conducting the MN test.
authors.affiliation: Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia.
authors.forename: A P
authors.initials: AP
authors.lastname: Simula
authors.forename: B G
authors.initials: BG
authors.lastname: Priestly
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D051379:Mice; D015162:Micronucleus Tests; D014677:Pharmaceutical Vehicles; D010938:Plant Oils / Q000633:toxicity*
chemical_list: D014677:Pharmaceutical Vehicles; D010938:Plant Oils