Preparation of thermo-responsive membranes. II.
Two types of liquid crystal (LC)-immobilized membranes were prepared by a soaking method and sandwich method to control the permeation of indomethacin, as a model drug, in response to local and systemic fever. Monooxyethylene trimethylolpropane tristearate (MTTS) was used as a model LC because it has a gel-liquid crystal phase transition temperature near the body temperature, 39-40 degrees C in phosphate buffered saline (pH 7.4). Two porous polypropylene (PP) membranes were soaked into 20% MTTS chloroform solution in the soaking method, and two PP membranes were poured with the melted MTTS and pressed in the sandwich method. Thermo-response efficacy of the soaked membrane was dependent upon the content of MTTS in MTTS membrane, and the MTTS content above the void volume of PP membrane (38%) was needed for high efficacy. On the other hand, the sandwich membrane exhibited higher thermo-response efficacy than the soaked membrane, because more LC was embedded in the pores of sandwich membrane than that of the soaked membrane. The sandwich membrane permeation of indomethacin was sharply controlled by temperature changes between 32 and 38 degrees C.
Nozawa
I
I
Applied Research Laboratory III, Lion Co., Ltd., Tokyo, Japan.
Suzuki
Y
Y
Sato
S
S
Sugibayashi
K
K
Morimoto
Y
Y
D000279:Administration, Cutaneous; D000818:Animals; D003692:Delayed-Action Preparations; D066298:In Vitro Techniques; D007213:Indomethacin / Q000493:pharmacokinetics; D008297:Male; D008567:Membranes, Artificial; D010539:Permeability; D011126:Polypropylenes / Q000737:chemistry; D011138:Polytetrafluoroethylene / Q000737:chemistry; D051381:Rats; D012869:Skin Absorption; D013228:Stearates / Q000737:chemistry*; D013816:Thermodynamics
D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D011126:Polypropylenes; D013228:Stearates; C070243:monooxyethylene trimethylolpropane tristearate; D011138:Polytetrafluoroethylene; D007213:Indomethacin