Thyroid-associated ophthalmopathy--a model for the association of organ-specific autoimmune disorders.
The development of a characteristic ophthalmopathy is a feature of autoimmune diseases of the thyroid. The link between the conditions has not yet been discovered, but here Jack Wall and colleagues develop the theory that an autoimmune response to a 64 kDa antigen expressed on both thyroid and eye muscle membranes is responsible for this thyroid-associated ophthalmopathy.
Wall
J R
JR
McGill University Thyroid Center, Montreal, Quebec, Canada.
Salvi
M
M
Bernard
N F
NF
Boucher
A
A
Haegert
D
D
D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D009801:Oculomotor Muscles / Q000276:immunology; D009915:Orbit / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
D001324:Autoantigens