title: Effects of paternal occupational exposure on spontaneous abortions.
abstract: BACKGROUND
  Paternal exposure to mutagenic agents has been suggested to affect pregnancy outcome adversely.
  
  
  METHODS
  A nationwide data base of medically diagnosed spontaneous abortions and other pregnancies and national census data was used to evaluate the effects of men's occupational exposures on risk of spontaneous abortion in 99,186 pregnancies in Finland. Census data from the years 1975 and 1980 provided information about the occupation, industry, and socioeconomic status. A job-exposure classification was developed to classify women and their husbands according to possible occupational exposures on the basis of their occupational title and industry.
  
  
  RESULTS
  In 10% of the pregnancies, the husband was exposed to one or more of the mutagens, and the rate of spontaneous abortion was unaffected (OR = 1.0). Of the 25 specific mutagenic exposures evaluated, paternal exposure to four (ethylene oxide, rubber chemicals, solvents used in refineries, and solvents used in the manufacturing of rubber products) was associated with an increased relative risk of spontaneous abortion. In addition, the risk of spontaneous abortion was higher among wives of rubber products workers than among unexposed men.
  
  
  CONCLUSIONS
  Although there is some biological rationale for the findings of this study, these findings need to be confirmed by studies in which individual exposures can be measured directly.
authors.affiliation: Institute of Occupational Health, Helsinki, Finland.
authors.forename: M L
authors.initials: ML
authors.lastname: Lindbohm
authors.forename: K
authors.initials: K
authors.lastname: Hemminki
authors.forename: M G
authors.initials: MG
authors.lastname: Bonhomme
authors.forename: A
authors.initials: A
authors.lastname: Anttila
authors.forename: K
authors.initials: K
authors.lastname: Rantala
authors.forename: P
authors.initials: P
authors.lastname: Heikkilä
authors.forename: M J
authors.initials: MJ
authors.lastname: Rosenberg
mesh_terms: D000022:Abortion, Spontaneous / Q000139:chemically induced* / Q000209:etiology; D002246:Carbon Disulfide / Q000009:adverse effects; D005220:Fathers; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D007854:Lead; D009153:Mutagens / Q000009:adverse effects*; D016273:Occupational Exposure; D009790:Occupations; D011247:Pregnancy
chemical_list: D009153:Mutagens; D007854:Lead; D002246:Carbon Disulfide