title: Fluvirucins A1, A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza A virus. I. Production, isolation, chemical properties and biological activities.
abstract: Five unidentified actinomycete strains produced a series of novel antiviral antibiotics which have a unique 2,6-dialkyl-10-ethyl-3(or 9)-hydroxy-13-tridecanelactam nucleus substituted with 3-amino-3,6-dideoxy-L-talose or 3-amino-3,6-dideoxy-L-mannose(L-mycosamine). The antibiotic components exhibited potent inhibitory activity against influenza virus type A Victoria strain infection in Madin Darby canine kidney cells by the cytopathic effect reduction assay.
authors.affiliation: Bristol-Myers Squibb Research Institute, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Naruse
authors.forename: O
authors.initials: O
authors.lastname: Tenmyo
authors.forename: K
authors.initials: K
authors.lastname: Kawano
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: N
authors.initials: N
authors.lastname: Ohgusa
authors.forename: T
authors.initials: T
authors.lastname: Miyaki
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: T
authors.initials: T
authors.lastname: Oki
mesh_terms: D000192:Actinomycetales / Q000145:classification / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003837:Deoxy Sugars / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004285:Dogs; D005285:Fermentation; D009980:Influenza A virus / Q000187:drug effects*; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D003837:Deoxy Sugars; D007769:Lactams