[Various aspects of the anti-aggregatory action of diltiazem and cordaphene in patients with ischemic heart disease].
Some aspects of the antiaggregatory action of calcium antagonists were studied in 50 patients with stable angina pectoris. Dilzem (diltiazem) and cordaphene (nifedipine) were tested for their effects on the erythrocytic component of hemostasis, taking into account their capability of suppressing hemolysis, which made ADP, an important thrombocytic activator, enter the blood flow. The two agents significantly reduce the concentration of plasma ADP, free hemoglobin, diminish mechanical erythrocytic resistance, and block platelet aggregation to a varying degree. A relationship was established between the levels of blood nifedipine and the magnitude of rheological effects. With this, the patients with coronary heart disease showed a good antianginal effect.
Leonova
M V
MV
Rumiantsev
D O
DO
Belousov
Iu B
IuB
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors / Q000097:blood; D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D004110:Diltiazem / Q000627:therapeutic use*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000502:physiology; D006461:Hemolysis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors
D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D004110:Diltiazem; D009543:Nifedipine
Nekotorye aspekty antiagregantnogo deĭstviia dilzema i kordafena u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.