title: Cell kinetics and hormonal features in relation to pathological stage in breast cancer.
abstract: Proliferative activity (expressed as 3H-thymidine labeling index, 3H-TdR LI) was evaluated on a series of 281 primary tumors recruited in two years in 6 different institutions from central Italy. 3H-TdR LI proved to be low in intraductal, or well and moderately differentiated, or hormone receptor positive tumors. Conversely, no relation was observed between 3H-TdR LI and menopause, tumor size, or lymph node involvement. An inverse relation was observed between 3H-TdR LI and hormone receptor content. Specific patterns of 3H-TdR LI value and ER content association were observed as a function of menopause, lymph nodal status, and degree of lymph nodal involvement.
authors.affiliation: Oncology Department, Morgagni-Pierantoni Hospital, U.S.L. 38, Forli, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Amadori
authors.forename: C
authors.initials: C
authors.lastname: Bonaguri
authors.forename: O
authors.initials: O
authors.lastname: Nanni
authors.forename: P
authors.initials: P
authors.lastname: Gentilini
authors.forename: N
authors.initials: N
authors.lastname: Lundi
authors.forename: W
authors.initials: W
authors.lastname: Zoli
authors.forename: A
authors.initials: A
authors.lastname: Riccobon
authors.forename: A
authors.initials: A
authors.lastname: Vio
authors.forename: E
authors.initials: E
authors.lastname: Magni
authors.forename: A
authors.initials: A
authors.lastname: Saragoni
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division; D005260:Female; D006801:Humans; D008593:Menopause / Q000502:physiology; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000096:biosynthesis*; D011980:Receptors, Progesterone / Q000096:biosynthesis*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone