Case report of metastatic familial pheochromocytoma treated with cisplatin and 5-fluorouracil.
We report on a rare case of malignant pheochromocytoma in a patient with a family history of this disease. After three cycles of treatment with cisplatin and 5-fluorouracil, a decrease in the need for antihypertensive treatment occurred, which lasted almost 2 years despite the discontinuation of chemotherapy. The patient showed an objective response, which was technically a minor response, although in this slow-growing tumor it was of major clinical significance. This chemotherapy regimen may play a role in the management of malignant pheochromocytoma.
Srimuninnimit
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Department of Medicine, Medical College of Virginia, Richmond 23298.
Wampler
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GL
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy* / Q000235:genetics; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D008159:Lumbar Vertebrae; D008175:Lung Neoplasms / Q000556:secondary; D010673:Pheochromocytoma / Q000188:drug therapy* / Q000235:genetics; D012074:Remission Induction; D012272:Ribs; D012447:Sacrum; D013125:Spinal Neoplasms / Q000556:secondary; D013899:Thoracic Neoplasms / Q000556:secondary; D013997:Time Factors
D002945:Cisplatin; D005472:Fluorouracil