Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients.
Six drug-free obsessive-compulsive patients were given single photon emission computerized tomography scans before and during treatment with fluoxetine. The treatment significantly reduced the patients' "hyperfrontality," as determined by the ratio between medial-frontal and whole cerebral cortex blood flow, and significantly lowered ratings of obsessive-compulsive and anxiety symptoms.
Hoehn-Saric
R
R
Department of Psychiatry, Johns Hopkins Hospital, Baltimore, MD 21205.
Pearlson
G D
GD
Harris
G J
GJ
Machlin
S R
SR
Camargo
E E
EE
D000328:Adult; D001007:Anxiety / Q000188:drug therapy / Q000523:psychology; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology* / Q000627:therapeutic use; D005625:Frontal Lobe / Q000098:blood supply* / Q000187:drug effects; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D015899:Tomography, Emission-Computed, Single-Photon
D005473:Fluoxetine