title: Local thrombolysis in the management of acute cerebral ischemia.
abstract: Local intraarterial fibrinolytic therapy (LIF) in patients with acute vertebrobasilar occlusion (AVBO) is a rational and, if successful, life saving treatment. The recent progress in this field is determined by the use of microcatheters for superselective basilar artery catheterisation and a "short-time, high-dose" regimen using 750,000 IU urokinase in not more than 2 h. Two out of 7 patients died and 1 did not improve to a better than a locked-in-state. Four patients, however, survived with excellent outcome.
authors.affiliation: Universitätskrankenhaus Eppendorf, Abteilung Neuroradiologie, Hamburg, Fed. Rep. of Germany.
authors.forename: H
authors.initials: H
authors.lastname: Zeumer
mesh_terms: D002533:Cerebral Angiography; D006801:Humans; D007262:Infusions, Intravenous; D002546:Ischemic Attack, Transient / Q000628:therapy*; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use; D014715:Vertebrobasilar Insufficiency / Q000628:therapy
chemical_list: D014568:Urokinase-Type Plasminogen Activator