title: Increase in basic fibroblast growth factor-like immunoreactivity in rat brain after forebrain ischemia.
abstract: Using immunohistochemical techniques, a study was conducted to determine whether basic fibroblast growth factor (bFGF) is generated as one of the 'self-repair' responses in rat brain following transient forebrain ischemia. In normal brain, slight bFGF-like immunoreactivity was observed. However, in rats exposed to 20 min of forebrain ischemia, intense bFGF-like immunoreactivity was observed in the CA1 subfield of the hippocampus and the caudate putamen, and marked activity was evident in the temporal cortex, corpus callosum and the CA4 subfield of the hippocampus. Marked neuronal degeneration was also observed in these brain regions following forebrain ischemia. These results suggest that induction of bFGF-like immunoreactivity may be related to the healing which follows brain ischemia.
authors.affiliation: Biology Research Laboratory, Takeda Chemical Ind. Ltd., Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kiyota
authors.forename: K
authors.initials: K
authors.lastname: Takami
authors.forename: M
authors.initials: M
authors.lastname: Iwane
authors.forename: A
authors.initials: A
authors.lastname: Shino
authors.forename: M
authors.initials: M
authors.lastname: Miyamoto
authors.forename: R
authors.initials: R
authors.lastname: Tsukuda
authors.forename: A
authors.initials: A
authors.lastname: Nagaoka
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000473:pathology*; D016222:Fibroblast Growth Factor 2 / Q000032:analysis*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006624:Hippocampus / Q000473:pathology*; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D011699:Putamen / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013702:Temporal Lobe / Q000473:pathology
chemical_list: D005904:Glial Fibrillary Acidic Protein; D016222:Fibroblast Growth Factor 2