Effect of long-term treatment of two tobacco-specific N-nitrosamines on the vitamin A status of mice.
The effect of long-term treatment of two important tobacco-specific N-nitrosamines, N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), on the depot or circulating levels of vitamin A of Swiss and BALB/c male mice was studied. It was observed that treatment of both NNN and NNK in Swiss and BALB/c mice decreased liver vitamin A levels significantly. NNK treatment also caused a decrease in the levels of vitamin A in plasma.
Padma
P R
PR
Carcinogenesis Division, Cancer Research Institute, Bombay, India.
Amonkar
A J
AJ
Bhide
S V
SV
D000818:Animals; D002273:Carcinogens / Q000032:analysis / Q000494:pharmacology*; D008099:Liver / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009602:Nitrosamines / Q000032:analysis / Q000494:pharmacology*; D010947:Plants, Toxic; D013997:Time Factors; D014026:Nicotiana / Q000032:analysis*; D014801:Vitamin A / Q000097:blood* / Q000378:metabolism
D002273:Carcinogens; D009602:Nitrosamines; D014801:Vitamin A; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; C008655:N'-nitrosonornicotine