title: High-performance liquid chromatography with electrochemical detection of buprenorphine and its major metabolite in urine.
abstract: A procedure was developed for the simultaneous determination of buprenorphine and its major metabolite. N-desalkylbuprenorphine, by reversed-phase high-performance liquid chromatography with electrochemical detection. The detection limit is about 100 pg/ml for the major metabolite and 250 pg/ml for buprenorphine.
authors.affiliation: Department of Toxicology, Katholieke Universiteit Leuven, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Debrabandere
authors.forename: M
authors.initials: M
authors.lastname: Van Boven
authors.forename: P
authors.initials: P
authors.lastname: Daenens
mesh_terms: D002047:Buprenorphine / Q000031:analogs & derivatives* / Q000652:urine*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004594:Electrophysiology; D006801:Humans
chemical_list: D002047:Buprenorphine; C043585:norbuprenorphine