A case of progressive encephalomyelitis with rigidity and positive antiglutamic acid decarboxylase antibodies [corrected].
A 50 year old woman developed progressive encephalomyelitis with rigidity over a three year period. Her CSF contained oligoclonal bands and both her serum and CSF contained antibodies directed against GABA-ergic synapses (antiglutamic acid decarboxylase [corrected] antibodies). These antibodies have recently been described in cases of stiff man syndrome. Both disorders may be part of a clinical spectrum that has an underlying autoimmune basis.
Burn
D J
DJ
Hammersmith Hospital, London, UK.
Ball
J
J
Lees
A J
AJ
Behan
P O
PO
Morgan-Hughes
J A
JA
D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology; D004679:Encephalomyelitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009127:Muscle Rigidity
D001323:Autoantibodies; D005968:Glutamate Decarboxylase