[Transitory acute kidney insufficiency and insulin-dependent after treatment of kala-azar with pentamidine and N-methylglucamine antimony].
Azotemia and diabetes mellitus are now well-known adverse reactions associated with Pentamidine treatment, especially since its prescription in case of Pneumocystis carinii pneumonia. We report the case of a 2 year-old boy, treated for kala-azar with pentamidine and N-methyl glucamine antimoniate who developed adverse effects, characterized by a nephrotic syndrome associated with the classic acute tubular necrosis, and transient diabetes mellitus.
Morin
D
D
Service de Pédiatrie I, Hôpital St-Charles, Montpellier.
Dumas
M L
ML
Valette
H
H
Dumas
R
R
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000378:metabolism; D000965:Antimony / Q000009:adverse effects* / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced* / Q000378:metabolism; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008297:Male; D008536:Meglumine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009404:Nephrotic Syndrome / Q000139:chemically induced; D010419:Pentamidine / Q000009:adverse effects* / Q000627:therapeutic use
D000981:Antiprotozoal Agents; C006601:antimony-N-methylglucamine; D010419:Pentamidine; D008536:Meglumine; D000965:Antimony
Insuffisance rénale aiguë et diabète insulino-dépendant transitoires au décours du traitement d'un kala-azar par pentamidine et antimoniate de N-méthylglucamine.