title: Improved physical performance after treatment of renal anemia with recombinant human erythropoietin.
abstract: The physical performance of 12 anemic patients on renal dialysis was investigated following treatment of renal anemia with recombinant human erythropoietin (rhEPO; 40-120 U/kg, 3 times a week). Exercise intensity at a heart rate of 130 beats/min (PWC130) on a bicycle ergometer was assessed before rhEPO treatment, after reaching the target hematocrit (73 +/- 18 days), and in the maintenance phase (211 +/- 53 days). Hemoglobin concentrations measured at these time points were 7.3 +/- 1.2, 11.9 +/- 1.5, and 12.1 +/- 1.4 g/dl, respectively. PWC130 rose from 77 +/- 27 to 104 +/- 37 and 104 +/- 51 W, respectively. Aerobic threshold (i.e. blood lactic acid concentration of 2 mmol/l) shifted to higher workloads indicating improved muscle oxygen supply.
authors.affiliation: Abteilung Sport- und Arbeitsphysiologie, Medizinische Hochschule Hannover, BRD.
authors.forename: K M
authors.initials: KM
authors.lastname: Braumann
authors.forename: B
authors.initials: B
authors.lastname: Nonnast-Daniel
authors.forename: D
authors.initials: D
authors.lastname: Böning
authors.forename: A
authors.initials: A
authors.lastname: Böcker
authors.forename: U
authors.initials: U
authors.lastname: Frei
mesh_terms: D000328:Adult; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D001794:Blood Pressure; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D006435:Renal Dialysis
chemical_list: D006454:Hemoglobins; D007773:Lactates; D004921:Erythropoietin; D019344:Lactic Acid