[The evaluation of the efficacy of antihypoxic agents lowering hemoglobin oxygen affinity in acute cerebral ischemia].
Influence of natrii hydroxybutyrate (100 mg/kg), ascorbate (100 mg/kg), cavinton (5 mg/kg), bemitil (50 mg/kg), ethomersol (50 mg/kg) on Hb-O2 affinity and cortex PO2 after both carotid artery occlusion in rats was investigated. Correlation (r-0.87; P less than 0.05) between lowering of Hb-O2 affinity and antihypoxic effect was demonstrated in the line of these drugs.
Plotnikova
T M
TM
Plotnikov
M B
MB
Bazhenova
T G
TG
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D001562:Benzimidazoles / Q000627:therapeutic use; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D006454:Hemoglobins / Q000187:drug effects* / Q000378:metabolism; D002534:Hypoxia, Brain / Q000097:blood / Q000188:drug therapy*; D010100:Oxygen / Q000097:blood*; D051381:Rats; D012978:Sodium Oxybate / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use*; D014748:Vinca Alkaloids / Q000627:therapeutic use
D000975:Antioxidants; D001562:Benzimidazoles; D006454:Hemoglobins; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine; C049825:bemethyl; D012978:Sodium Oxybate; D001205:Ascorbic Acid; D010100:Oxygen
Otsenka éffektivnosti pri ostroĭ ishemii mozga antigipoksantov, umen'shaiushchikh affinitet gemoglobina k kislorodu.