Clinical efficacy of an anticalculus fluoride dentifrice containing triclosan and a copolymer: a 6-month study.
A 6-month, double-blind, parallel and unsupervised clinical study was conducted to compare the effects on supragingival calculus formation of a dentifrice containing 0.3% triclosan and 2.0% of a copolymer in a 0.243% sodium fluoride/silica base, as compared to a placebo dentifrice containing 0.243% sodium fluoride in a silica base. Subjects were initially stratified into two balanced groups based on their Volpe-Manhold calculus index scores that were obtained from a 3-month pre-test period using a placebo dentifrice. All subjects received an oral prophylaxis and were assigned to the use of either the fluoride/triclosan/copolymer dentifrice or the placebo dentifrice. Seventy adult male and female subjects completed the entire 6-month study. The results after 3-months' use of their respective dentifrices indicated that the subjects using the fluoride/triclosan/copolymer dentifrice had 26.34% less supragingival calculus formation than the subjects using the placebo dentifrice. This reduction in supragingival calculus was significant at the 99% level of confidence. The results after 6 months indicated that the subjects using the fluoride/triclosan/copolymer dentifrice had 36.27% less supragingival calculus formation than the subjects using the placebo dentifrice. This reduction was significant at the 99% level of confidence.
Lobene
R R
RR
Battista
G W
GW
Petrone
D M
DM
Volpe
A R
AR
Petrone
M E
ME
D000328:Adult; D000704:Analysis of Variance; D003728:Dental Calculus / Q000517:prevention & control*; D003802:Dentifrices; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008298:Maleates / Q000008:administration & dosage*; D011145:Polyvinyls / Q000008:administration & dosage*; D012969:Sodium Fluoride / Q000008:administration & dosage; D014260:Triclosan / Q000008:administration & dosage*
D003802:Dentifrices; D008298:Maleates; D011145:Polyvinyls; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D014260:Triclosan; D012969:Sodium Fluoride