title: [Induction of autoreactive T-cells by bacterial stress proteins in HLA-DR4 donors].
abstract: From the peripheral blood of HLA-DR4+ healthy donors or patients with rheumatoid arthritis autoreactive T-cell lines were obtained after stimulation with bacterial heat-shock protein. All lines obtained express an alpha/beta-T-cell receptor and they are predominantly CD4+. The determination of the fine specificity of those autoreactive T cells showed, that either amino-acid position #71 or #86 of the HLA-DR beta 1 chain was critical for recognition by the antigen receptor.
authors.affiliation: Max-Planck-Institut für Psychiatrie, Martinsried.
authors.forename: C
authors.initials: C
authors.lastname: Epplen
authors.forename: R
authors.initials: R
authors.lastname: Mitreiter
authors.forename: H
authors.initials: H
authors.lastname: Hatz
authors.forename: K
authors.initials: K
authors.lastname: Helmke
authors.forename: E
authors.initials: E
authors.lastname: Albert
authors.forename: J T
authors.initials: JT
authors.lastname: Epplen
mesh_terms: D001782:Blood Donors; D015804:HLA-DR4 Antigen / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015804:HLA-DR4 Antigen; D006360:Heat-Shock Proteins; D011948:Receptors, Antigen, T-Cell
vernacular_title: Induktion autoreaktiver T-Zellen durch bakterielle Stressproteine bei HLA-DR4(+)-Spendern.