[The effect of sulfur-containing preparations on the development of immediate allergization].
The effects of sulfur-containing drugs and an inhibitor of sulfhydryl groups on the development of allergization of immediate type were studied. In experiments on rabbits and guinea pigs it was shown that the effects of sulfur-containing drugs depend on the dose, the stage of the allergic process. The donors of sulfhydryl groups significantly reduce anaphylactic shock and repeated allergic reactions of immediate type. The inhibitor of sulfhydryl groups produces the dose-dependent increase or decrease of the allergic reaction. The studied drugs change the dynamics of the content of sulfhydryl groups during sensitization.
Chetverikov
G N
GN
Smirnova
V V
VV
Demidova
M A
MA
D000707:Anaphylaxis / Q000139:chemically induced / Q000276:immunology; D000818:Animals; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D006168:Guinea Pigs; D006969:Hypersensitivity, Immediate / Q000139:chemically induced* / Q000276:immunology; D007114:Immunization / Q000379:methods; D011817:Rabbits; D012835:Silver Nitrate / Q000494:pharmacology; D013439:Sulfhydryl Reagents / Q000494:pharmacology*; D013447:Sulfites / Q000494:pharmacology; D013455:Sulfur / Q000494:pharmacology*; D013885:Thiosulfates / Q000494:pharmacology; D013997:Time Factors; D014494:Unithiol / Q000494:pharmacology
D013439:Sulfhydryl Reagents; D013447:Sulfites; D013885:Thiosulfates; D014494:Unithiol; D013455:Sulfur; D012835:Silver Nitrate; C017717:sodium thiosulfate; C025026:sodium sulfite
Vliianie serosoderzhashchikh preparatov na razvitie allergizatsii nemedlennogo tipa.