title: Iontophoresis of vasoactive drugs. Effect on peripheral blood flow during pregnancy.
abstract: The aim of this study was to evaluate whether iontophoretic administration of the vasoactive agents noradrenaline (NA) and angiotensin (AII) combined with measurement of skin blood flow with a laser Doppler technique could serve as a predictive method for pre-eclampsia. Nine healthy non-pregnant women, 9 healthy pregnant women and 9 pre-eclamptic patients were investigated. A significant reduction of skin blood flow was induced by NA in all three groups and by AII in the non-pregnant group. There was no significant difference between healthy pregnant and pre-eclamptic patients in the degree of reduction of blood flow with respect to NA and AII administration.
authors.affiliation: Department of Obstetrics and Gynecology, Södersjukhuset, Stockholm, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Eneroth-Grimfors
authors.forename: L E
authors.initials: LE
authors.lastname: Lindblad
authors.forename: M
authors.initials: M
authors.lastname: Westgren
authors.forename: B M
authors.initials: BM
authors.lastname: Etzell
authors.forename: S
authors.initials: S
authors.lastname: Bevegård
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007478:Iontophoresis; D007834:Lasers; D009638:Norepinephrine / Q000008:administration & dosage*; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*
chemical_list: D000804:Angiotensin II; D009638:Norepinephrine