Status of the search for a major genetic locus for affective disorder in the Old Order Amish.
We have resumed the search for an autosomal linkage with affective disorder in the Old Order Amish and report the pairwise linkage results after screening 185 marked loci. No positive evidence of genetic linkage was found, and we estimate that roughly 23% of the autosomal genome has been excluded from linkage.
Pakstis
A J
AJ
Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510.
Kidd
J R
JR
Castiglione
C M
CM
Kidd
K K
KK
D001714:Bipolar Disorder / Q000208:ethnology / Q000235:genetics*; D002835:Christianity; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D003466:Cultural Characteristics; D005006:Ethnicity; D008040:Genetic Linkage; D005828:Genetics, Population; D006801:Humans; D008126:Lod Score