title: Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db).
abstract: The autosomal recessive mutations fa (rat) and db (mouse) cause obesity syndromes that develop early and ultimately become severe. Although both fa/fa rats and db/db mice have been studied extensively as models of human obesity and diabetes, the molecular bases of these phenotypes remain unknown. We have mapped fa in 50 fa/fa (obese) offspring of a (13M x Brown Norway) F1 fa/+ intercross relative to two molecular markers, Ifa and Glut-1, which flank db on mouse chromosome 4 and which are located on rat chromosome 5. Ifa and Glut-1 are linked to fa, with a gene order, Ifa-fa-Glut-1, that is identical to that for the region around db in the mouse genome. These results place fa on rat chromosome 5 and suggest that db and fa are mutations in homologous genes.
authors.affiliation: Laboratory of Human Behavior and Metabolism, Rockefeller University, New York, NY 10021.
authors.forename: G E
authors.initials: GE
authors.lastname: Truett
authors.forename: N
authors.initials: N
authors.lastname: Bahary
authors.forename: J M
authors.initials: JM
authors.lastname: Friedman
authors.forename: R L
authors.initials: RL
authors.lastname: Leibel
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003921:Diabetes Mellitus, Experimental / Q000235:genetics*; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D005838:Genotype; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D008969:Molecular Sequence Data; D009765:Obesity / Q000235:genetics*; D015345:Oligonucleotide Probes; D051381:Rats; D011922:Rats, Mutant Strains; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid
chemical_list: D015345:Oligonucleotide Probes