[The behavior of radioactive albumin microspheres on administration into the hepatic artery of animals].
A study was made of the behaviour of human serum albumin microspheres--SAM-- (USSR) during intraarterial selective infusion of them in the hepatic artery of rabbits. 125I was used as a radioactive tracing agent. Accumulation of the agent in organs and its excretion were investigated over time by radiometry in vivo and in vitro. Distribution of 125I-SAM in the liver at administration of different amounts of the radioactive drug was also investigated. A mathematical formula of calculation of the optimum amount of administered microspheres was proposed. A conclusion was made of a possibility of the use of the SAM as a carrier of short-lived radionuclides for endovascular radiotherapy of malignant hepatic tumors.
Drozdovskiĭ
B Ia
BIa
Roziev
R A
RA
Goncharova
A Ia
AIa
D000418:Albumins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D005260:Female; D006499:Hepatic Artery; D007261:Infusions, Intra-Arterial; D007457:Iodine Radioisotopes; D008297:Male; D008863:Microspheres; D011817:Rabbits; D014018:Tissue Distribution
D000418:Albumins; D007457:Iodine Radioisotopes
Povedenie radioaktivnykh mikrosfer al'bumina pri vvedenii ikh v pechenochnuiu arteriiu zhivotnykh.