In vitro effect of larval stages of Ascaris lumbricoides on human blood clotting.
The effects of larval stages of Ascaris lumbricoides on human blood clotting was studied in vitro. Extracts and excretory/secretory products of third-stage larvae (L3) and late third-stage larvae (LL3) cultured from ova obtained from infected patients were analysed for anti-coagulant activity. Prothrombin time (PT) was prolonged by the addition of either whole extract of L3/LL3 or ES products of L3/LL3 as compared to controls. Partial thromboplastin time with kaolin (PTTK) was also prolonged on the addition of either extracts of ES products of L3/LL3. The prolongation of PTTK was significantly higher with extracts/ES products of L3 when compared to the extracts/ES products of LL3 (p less than 0.005). Thrombin time (TT) was prolonged by extracts of L3/LL3 and their ES products.
Malla
N
N
Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Sofi
B A
BA
Ganguly
N K
NK
Mahajan
R C
RC
D000818:Animals; D001200:Ascaris / Q000502:physiology*; D001777:Blood Coagulation; D006801:Humans; D007616:Kaolin; D007814:Larva / Q000502:physiology; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D013918:Thrombin Time
D007616:Kaolin