title: Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria.
abstract: The administration of 0.5 g (IM) of desferrioxamine every 12 hr for 3 days with 25 mg/kg (total dose for three days) of chloroquine abated the parasitemia of Plasmodium falciparum infected individuals more rapidly than chloroquine alone. Two patients with in vitro evidence of total or partial resistance to chloroquine also were successfully treated with the combination of drugs, and were free of parasitized red cells by day 7. Further clinical trials and development of desferrioxamine in the treatment of P. falciparum are warranted.
authors.affiliation: OCEAC and Ministry of Health, Yaounde, Cameroon.
authors.forename: O
authors.initials: O
authors.lastname: Traore
authors.forename: P
authors.initials: P
authors.lastname: Carnevale
authors.forename: L
authors.initials: L
authors.lastname: Kaptue-Noche
authors.forename: J
authors.initials: J
authors.lastname: M'Bede
authors.forename: M
authors.initials: M
authors.lastname: Desfontaine
authors.forename: J
authors.initials: J
authors.lastname: Elion
authors.forename: D
authors.initials: D
authors.lastname: Labie
authors.forename: R L
authors.initials: RL
authors.lastname: Nagel
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use; D003676:Deferoxamine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D010270:Parasite Egg Count; D010963:Plasmodium falciparum
chemical_list: D002738:Chloroquine; D003676:Deferoxamine