Effect of staggered dose of calcium on the bioavailability of ciprofloxacin.
The effect on ciprofloxacin's bioavailability (F) of calcium carbonate given 2 h before ciprofloxacin administration in 12 male volunteers was studied. The relative F with calcium was 0.98, maximum concentration of drug in serum increased significantly from 1.98 to 2.42 mg/liter (P = 0.039), and time to maximum concentration of drug in serum decreased from 1.82 to 1.26 h (P = 0.038). Thus, a single calcium carbonate dose, administered 2 h before ciprofloxacin, does not alter the F of this quinolone.
Lomaestro
B M
BM
Department of Pharmacy, Albany Medical Center, New York.
Bailie
G R
GR
D000328:Adult; D001682:Biological Availability; D002118:Calcium / Q000493:pharmacokinetics; D002119:Calcium Carbonate / Q000008:administration & dosage* / Q000494:pharmacology; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008954:Models, Biological
D002939:Ciprofloxacin; D002119:Calcium Carbonate; D002118:Calcium