title: [Comparative studies on the effect of nasal CPAP, theophylline and oxygen in patients with sleep apnea syndrome].
abstract: In patients with sleep apnea-syndrome nasal CPAP-therapy is the method of choice. The apnea phases are practically completely eliminated. However some patients with SAS don't accept CPAP-therapy. In this group Theophylline or O2-therapy respectively is discussed. We examined therefore 21 patients (55.8 +/- 9 years) with sleep-apnea syndrome and an apnea-index of 39 +/- 19.9 during 4 consecutive nights (diagnosis, nCPAP-therapy, O2-therapy by 21/min, by nasal prongs and Theophylline 375-400 mg in the evening and calculated apnea-index, the longest apnea and the lowest O2-saturation. On CPAP the number of apneas was practically reduced to 0. On Theophylline there was a relevant reduction of the apnea frequency. On O2-therapy only few patients with non-compliance Theophylline-therapy can be of some benefit in patients with moderate sleep-apnea syndrome. However the apnea-index cannot be normalized.
authors.affiliation: Klinik Ambrock, Zentrum für Pneumologie und Thoraxchirurgie, Hagen.
authors.forename: P
authors.initials: P
authors.lastname: Kempf
authors.forename: B
authors.initials: B
authors.lastname: Mössinger
authors.forename: B
authors.initials: B
authors.lastname: Müller
authors.forename: T
authors.initials: T
authors.lastname: Kirchheiner
authors.forename: K H
authors.initials: KH
authors.lastname: Rühle
mesh_terms: D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D011175:Positive-Pressure Respiration / Q000379:methods*; D012891:Sleep Apnea Syndromes / Q000097:blood / Q000628:therapy*; D013806:Theophylline / Q000627:therapeutic use*
chemical_list: D013806:Theophylline; D010100:Oxygen
vernacular_title: Vergleichsuntersuchungen zur Wirkung von nCPAP, Theophyllin und Sauerstoff bei Patienten mit Schlafapnoesyndrom.