[A comparative study of the nootropic properties of piracetam and oxiracetam].
The behavioral activities of piracetam and oxiracetam were studied during the learning tests (active avoidance, passive avoidance, T-maize). The levels of the orientation reaction and emotionality of the animals were determined by the "open field" method. To achieve similar effects, injections of 10 mg/kg of oxiracetam and 100 mg/kg of piracetam intraperitoneally were required. Both nootropics facilitated the learning of the animals but failed to change their behavior in the open field. Piracetam was more effective in the active avoidance test and oxiracetam in the T-maize test. The data indicate some differences in the activities of piracetam and oxiracetam.
Krylova
I N
IN
Antonova
L V
LV
Kamenskiĭ
A A
AA
Iasnetsov
V V
VV
D000648:Amnesia, Retrograde / Q000188:drug therapy / Q000209:etiology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005247:Feeding Behavior / Q000187:drug effects; D008297:Male; D010889:Piracetam / Q000494:pharmacology* / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000627:therapeutic use; D011759:Pyrrolidines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D011619:Psychotropic Drugs; D011759:Pyrrolidines; C040619:oxiracetam; D010889:Piracetam
Sravnitel'noe izuchenie nootropnykh svoĭstv piratsetama i oksiratsetama,