[The characteristics of the programming action of androgens on the formation of sexual dimorphism in the level of corticosteroid-binding globulin in rats].
The role of sex steroids in the programming of the level of serum corticosteroid binding globulin (CBG) of male and female rats has been studied at different stages of ontogenesis. It was shown that castration of adult males lead to the increase of the level of CBG, but not to the elimination of sex differences. Gonadectomy of males up to 28th day of postnatal life results in complete feminization of the CBG content in these animals at the age of 10-12 weeks. The castration after 35th day of life does not prevent the formation of the male phenotype of CBG content. The results of administration of testosterone-propionate (TP) to castrated males at different periods of ontogenesis suggests that the sensitivity to irreversible negative action of androgens appears after 28th day of life and disappears after the puberty. It was concluded that short period of ontogenesis from 29th to 35th days of life is critical for the realization of the irreversible masculinization of CBG level upon the influence of androgens in the physiological conditions. It was found that injections of both synthetic estrogens diethylstilbestrol or TP in the sensitive period of ontogenesis lead to the expression of male phenotype of CBG level in a similar fashion.
Kurabekova
R M
RM
Mataradze
G D
GD
Rozen
V B
VB
D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004054:Diethylstilbestrol / Q000494:pharmacology; D005260:Female; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D051381:Rats; D012727:Sex Characteristics; D013739:Testosterone / Q000494:pharmacology; D045165:Testosterone Congeners / Q000494:pharmacology*; D014156:Transcortin / Q000032:analysis / Q000187:drug effects*
D045165:Testosterone Congeners; D013739:Testosterone; D004054:Diethylstilbestrol; D014156:Transcortin
Osobennosti programmiruiushchego deĭstviia androgenov na formirovanie polovogo dimorfizma urovnia kortikosteroidsviazyvaiushchego globulina u krys.