Immunoglobulin G subclass deficiency in children with recurrent respiratory tract infections.
With monoclonal antibodies serum immunoglobulin G(IgG) subclasses were measured in seventy children aged 2 to 13 years with recurrent respiratory tract infections including upper respiratory tract infections, otitis media, sinusitis, asthmatic bronchitis and pneumonia. 211 healthy, aged-matched children served as control. IgG subclass deficiency was found in 19 out of the 70 patients (27.1%, single IgG1 deficiency in 7, IgG2 deficiency in 4, combined IgG1-IgG3 deficiency in 5, IgG1-IgG2-IgG3-IgG4 deficiency, IgG1-IgG2-IgG4 deficiency and IgG2-IgG4 deficiency each in 1). The incidence of IgG subclass deficiencies was in the sequence as follows: IgG1, 20%; IgG2, 10%; IgG3, 8.6% and IgG4, 4.3%. The results suggest that IgG subclass deficiency indicate a common disorder in children with recurrent respiratory tract infections.
Jiang
L P
LP
Children's Hospital, Chongqing University of Medical Sciences.
Yang
X Q
XQ
Li
C R
CR
Zhang
Y W
YW
Wang
L J
LJ
Shen
J
J
D000293:Adolescent; D001991:Bronchitis / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000150:complications*; D005260:Female; D006801:Humans; D017099:IgG Deficiency; D008297:Male; D011014:Pneumonia / Q000276:immunology; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000209:etiology / Q000276:immunology*