[Ca+-dependent efflux of K+ from erythrocytes, induced by an oxidative process].
Effects of inhibitors of energetic processes, antioxidants and SH-reagents on Ca(2+)-dependent K+ efflux from human red blood cells induced by oxidizing agents, electron donor system ascorbate + phenazine methosulphate (PMS) and Na periodate were investigated. We concluded that different regulatory mechanisms of K+ efflux from cells existed. In contract to periodate effect, Ca(2+)-dependent K+ channel activated by ascorbate + PMS is functionally connected with the membrane redox components.
Giul'khandanian
A V
AV
Geokchakian
G M
GM
D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002413:Cations, Divalent; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008773:Methylphenazonium Methosulfate / Q000378:metabolism; D010084:Oxidation-Reduction; D011188:Potassium / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D000975:Antioxidants; D002413:Cations, Divalent; D013438:Sulfhydryl Compounds; D008773:Methylphenazonium Methosulfate; D001205:Ascorbic Acid; D011188:Potassium; D002118:Calcium
Ca+-zavisimyĭ vykhod K+ iz éritrotsitov, indutsirovannyĭ okislitel'nymi protsessami.