The cell content of peritoneal exudates following the injection of neutral thiol protease into guinea pigs.
The cell content of the peritoneal exudate was examined 4 days after an intraperitoneal injection of glycogen in uninfected and Paragonimus westermani-infected guinea pigs. In uninfected animals a reduction in macrophage count and an accumulation of granulocytes in the exudate were observed at 3 and 6 hr after an intraperitoneal injection of purified neutral thiol protease from P. westermani metacercariae. No such effect occurred after the enzyme was injected into infected animals. At 9 hr after enzyme injection, vacuoles were found in the cytoplasm of macrophages in uninfected animals.
Hamajima
F
F
Department of Parasitology, National Defense Medical College, Tokorozawa, Japan.
Yamakami
K
K
Fukuda
K
K
Tsuru
S
S
Fujino
T
T
Hamajima
H
H
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D002465:Cell Movement / Q000187:drug effects; D002846:Chromatography, Affinity; D003546:Cysteine Endopeptidases / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology; D006168:Guinea Pigs; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D010238:Paragonimus / Q000201:enzymology
D003546:Cysteine Endopeptidases