Chocolate is a migraine-provoking agent.
Patients with migraine who believed that chocolate could provoke their attacks were challenged with either chocolate or a closely matching placebo. In a double-blind parallel group study, chocolate ingestion was followed by a typical migraine episode in 5 out of 12 patients, while none of the 8 patients challenged with placebo had an attack (p = 0.051). The median time to the onset of the attack was 22 h. This brief study provides some objective evidence that chocolate is able to provoke a migraine attack in certain patients who believe themselves sensitive to it.
Gibb
C M
CM
Bernhard Baron Memorial Research Laboratories, Queen Charlotte's and Chelsea Hospital, London.
Davies
P T
PT
Glover
V
V
Steiner
T J
TJ
Clifford Rose
F
F
Sandler
M
M
D000328:Adult; D002099:Cacao / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000139:chemically induced*