[The prognostic value of the serial determination of galactose elimination capacity in chronic active hepatitis].
The prognostic value of different conventional liver tests was compared with that of the galactose elimination capacity (GEC) in 37 patients with chronic active hepatitis. During a mean observation period of 4.5 years, 12 patients died of the disease. None of the conventional liver tests (transaminases, prothrombin time, albumin, Child-Pugh classification) discriminated between survivors and nonsurvivors. In contrast, GEC discriminated between survivors and nonsurvivors (p less than 0.04). The best prognostic criterion was a decrease in GEC, since only patients with a decrease died of the disease. The positive and negative predictive values of this criterion were 100 and 60% respectively. This concept could prove useful for stratification purposes in therapeutic trials, as well as in assessment of novel forms of treatment of chronic active hepatitis.
Aebli
N
N
Institut für Klinische Pharmakologie, Universität Bern.
Reichen
J
J
D000328:Adult; D000368:Aged; D005260:Female; D005690:Galactose / Q000378:metabolism; D006521:Hepatitis, Chronic / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016019:Survival Analysis
D005690:Galactose
Prognostische Wertigkeit der seriellen Bestimmung der Galaktose-Eliminationskapazität bei chronisch-aktiver Hepatitis.