Nephrotoxic effects of diethylene glycol (DEG) in rats.
Diethylene glycol (DEG) is a widely used substance with various risks of intoxication. In adult rats influences of DEG on functional parameters are characterized, indicating early signs of nephrotoxicity. A dose dependent proteinuria, an oliguric effect, an increased excretion of free hydrogen ions and a compensated impairment of renal tubular transport processes can be stated (0.25, 0.5 and 0.75 ml DEG/100 g b.m. i.p.). Following a single dose of 0.5 ml DEG/100 g b.m. i.p. the maximally expressed nephrotoxic effect is measurable 4 to 8 days after administration.
Kraul
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Friedrich Schiller University Jena, F.R.G.
Jahn
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Bräunlich
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D005026:Ethylene Glycols / Q000633:toxicity*; D005260:Female; D006859:Hydrogen / Q000652:urine; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains
D005026:Ethylene Glycols; C013484:diethylene glycol; D006859:Hydrogen