Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor.
During development of the Drosophila retina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmembrane proteins encoded by bride of sevenless and sevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo.
Krämer
H
H
Department of Biological Chemistry, School of Medicine, University of California, Los Angeles 90024-1737.
Cagan
R L
RL
Zipursky
S L
SL
D000818:Animals; D002449:Cell Aggregation; D004247:DNA / Q000235:genetics; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins; D005136:Eye Proteins / Q000235:genetics / Q000502:physiology*; D008024:Ligands; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D009030:Mosaicism; D009154:Mutation; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D010786:Photoreceptor Cells / Q000166:cytology / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases
D029721:Drosophila Proteins; D005136:Eye Proteins; D008024:Ligands; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D004247:DNA; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; C056737:sev protein, Drosophila