Noninvasive diagnostic imaging in hemoglobinopathies.
We have provided a global review of the current applications of newer modalities, particularly MR imaging, as applicable to the major manifestations of sickle cell disease, the most common hemoglobinopathy. There is a need for well-designed prospective longitudinal studies utilizing MR imaging to gain further insight into the pathophysiology of this intriguing disease. Additionally, MR imaging, because of lack of ionizing radiation, is ideally suited for long-term sequential studies and may thus provide an objective means for monitoring response to therapy.
Rao
V M
VM
Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Sebes
J I
JI
Steiner
R M
RM
Ballas
S K
SK
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000473:pathology*; D001659:Biliary Tract / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D001921:Brain / Q000473:pathology; D002675:Child, Preschool; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D013154:Spleen / Q000473:pathology