[Changes in kinetics of deaminated biogenic amines in spontaneous hypertension].
Rate of serotonin and benzylamine deamination was increased in liver tissue of rats with spontaneous hypertension. The increase was due to elevation in Vmax value for monoamine oxidases of the A and B types as compared with the corresponding values of control animals. The Vmax value was increased in kidney of hypertensive animals for MAO of the B type (benzylamine as a substrate). At the same time, Km for MAO of the B type was increased in liver tissue, while Km for MAO of the A type was decreased in brain of hypertensive animals. Titration of the MAO active sites exhibited their increased concentration in the B type MAO in liver mitochondria of experimental animals. The data obtained suggest an important role of alterations in the MAO catalytic activity in pathogenesis of spontaneous hypertension.
Ioffina
D I
DI
Smirnov
I E
IE
Gorkin
V Z
VZ
D000588:Amines / Q000737:chemistry; D000818:Animals; D001596:Benzylamines / Q000378:metabolism; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism
D000588:Amines; D001596:Benzylamines; D001679:Biogenic Amines; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; C030796:benzylamine; D008995:Monoamine Oxidase
Izmemeniia kinetiki dezaminirovaniia biogennykh aminov pri spontannoĭ gipertenzii.