title: Influence of acetyl-L-carnitine infusion on haemodynamic parameters and survival of circulatory-shock patients.
abstract: The clinical use of acetyl carnitine in circulatory shock has its theoretical basis in the ability of this molecule to restore enzyme activity inhibited by hypoxia, acting as an acetyl donor. Moreover the action of carnitine on an injured myocardium encouraged us to examine the clinical effect of this drug during heart failure. A double-blind clinical study was performed in ten Italian intensive care units on 115 patients with septic, cardiac of traumatic shock, by using acetyl-L-carnitine infusion for 12 hours, with a previous single bolus intravenously. The results showed a good response to the drug in terms of blood oxygenation during the course of sepsis and heart failure. The heart rate as well as right atrial pressure decreased significantly in patients with cardiogenic shock. In septic patients systolic and mean arterial pressures increased also. The present data suggests the use of acetyl-L-carnitine as an adjuvant to the commonly used therapy in hypoxic conditions.
authors.affiliation: Institute of Anaesthesia and Intensive Care, University La Sapienza Policlinico Umberto I, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gasparetto
authors.forename: G G
authors.initials: GG
authors.lastname: Corbucci
authors.forename: R A
authors.initials: RA
authors.lastname: De Blasi
authors.forename: M
authors.initials: M
authors.lastname: Antonelli
authors.forename: E
authors.initials: E
authors.lastname: Bagiella
authors.forename: S
authors.initials: S
authors.lastname: D'Iddio
authors.forename: C
authors.initials: C
authors.lastname: Trevisani
mesh_terms: D000108:Acetylcarnitine / Q000008:administration & dosage / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D015924:Blood Pressure Monitors; D004311:Double-Blind Method; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007362:Intensive Care Units; D008875:Middle Aged; D012769:Shock / Q000188:drug therapy*; D012770:Shock, Cardiogenic / Q000188:drug therapy; D012772:Shock, Septic / Q000188:drug therapy; D012774:Shock, Traumatic / Q000188:drug therapy; D015996:Survival Rate
chemical_list: D000108:Acetylcarnitine