Chicken erythrocyte membrane: lipid profile and enzymatic activity under lanthanum chloride and neodymium chloride administration.
Acute single dose (ip) administration of two rare earth elements like lanthanum chloride (250 mg/kg body wt) and neodymium chloride (200 mg/kg body wt) to chicks have been found to reduce the activity of certain erythrocyte membrane bound enzymes, viz. acetylcholinesterase, NADH dehydrogenase, Mg(2+)-ATPase, p-nitrophenyl phosphatase. Erythrocyte membrane bound glycosidases e.g. beta-D-glucosidase, beta-D-galactosidase and beta-D-glucuronidase were also reduced. Other components such as cholesterol and phospholipid residues were reduced but their ratio (cholesterol/phospholipid) remaining unchanged. Membrane sulfhydryl groups were also significantly inhibited by these rare earth elements.
Ghosh
N
N
Department of Biochemistry, University College of Science, Calcutta, India.
Chattopadhyay
D
D
Chatterjee
G C
GC
D000818:Animals; D002645:Chickens; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000097:blood; D007811:Lanthanum / Q000633:toxicity; D008297:Male; D008563:Membrane Lipids / Q000097:blood; D009354:Neodymium / Q000633:toxicity
D008563:Membrane Lipids; C028521:lanthanum chloride; C053739:neodymium chloride; D009354:Neodymium; D007811:Lanthanum; D006026:Glycoside Hydrolases