The cellular mechanism of action of bisphosphonates.
Present understanding of the cellular mechanism of action of bisphosphonates as in vitro and in vivo inhibitors of bone resorption is reviewed. This mechanism appears to involve the osteoclast at more than one stage of its maturation process, and way well be receptor-mediated, although the molecular mechanism itself is thus far unknown.
Hughes
D E
DE
Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, UK.
Mian
M
M
Guilland-Cumming
D F
DF
Russell
R G
RG
D000818:Animals; D001862:Bone Resorption; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D004164:Diphosphonates / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D016207:Cytokines; D004164:Diphosphonates