title: Single daily dose amikacin in paediatric patients with severe gram-negative infections.
abstract: Twenty-five children with serious Gram-negative infections were treated in a prospective study with amikacin 20 mg/kg administered in a single daily dose as a 30 min iv infusion for 4 to 12 days. In nine cases the amikacin was combined with beta-lactam antibiotics. Escherichia coli were the most frequent bacteria isolated followed by K. pneumoniae, Providencia and Enterobacter spp. and Pseudomonas aeruginosa with MICs ranging from 1 to 16 mg/l. Mean (+/- S.D.) peak and trough concentrations of days 1 and 4 of therapy ranged from 49 +/- 13.5 to 53.6 +/- 13.4 mg/l and 6 + 1.4 to 7.7 +/- 4.1 mg/l respectively. All patients were clinically and bacteriologically cured. No significant adverse reactions were observed. The results suggest that administration of a single daily dose of 20 mg/kg amikacin should be considered practical and safe in children. Further studies are needed.
authors.affiliation: Hospital Pablo Tobon Uribe, Medellin, Colombia.
authors.forename: H
authors.initials: H
authors.lastname: Trujillo
authors.forename: J
authors.initials: J
authors.lastname: Robledo
authors.forename: C
authors.initials: C
authors.lastname: Robledo
authors.forename: D
authors.initials: D
authors.lastname: Espinal
authors.forename: G
authors.initials: G
authors.lastname: Garces
authors.forename: J
authors.initials: J
authors.lastname: Mejia
authors.forename: C
authors.initials: C
authors.lastname: Restrepo
authors.forename: F
authors.initials: F
authors.lastname: Restrepo
authors.forename: G I
authors.initials: GI
authors.lastname: Mejia de Rodriguez
authors.forename: M C
authors.initials: MC
authors.lastname: Tamayo de Guitierrez
mesh_terms: D000293:Adolescent; D000583:Amikacin / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use; D004756:Enterobacteriaceae Infections / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007769:Lactams; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D007769:Lactams; D000583:Amikacin; D003404:Creatinine