Aztreonam biliary excretion in bile duct ligated jaundiced rats.
An experimental study was undertaken to assess aztreonam biliary concentrations in bile duct ligated jaundiced rats. The study proved that aztreonam biliary concentrations are sufficient to inhibit Gram-negative bacteria within the first and the second hour after antibiotic administration. The experimental model suggests that clinical conditions such as lithiasis or neoplasms of the biliary tree should not totally inhibit the antibiotic excretion.
Rulli
F
F
Cattedra di Patologia Speciale Chirurgica e Propedeutica Clinica, II Università di Roma.
Muzi
M
M
Zanella
E
E
Cipriani
P
P
Magni
A
A
Giordano
A
A
Filadoro
F
F
D000818:Animals; D001398:Aztreonam / Q000032:analysis*; D001646:Bile / Q000737:chemistry*; D001652:Bile Ducts / Q000503:physiopathology*; D001651:Cholestasis, Extrahepatic / Q000209:etiology*; D008026:Ligation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001398:Aztreonam