[Development of slow releasing anticancer drug based with absorbable biomaterial chitin].
To have a comparatively more slowly releasing anticancer drug with effectiveness, Plachitin was prepared by chemical combination of CDDP and chitin (poly-N-acetyl-D-glucosamine). Chitin is absorbed by the living body over several months. To investigate the slow releasing property, it was implanted in thigh muscle of mice and rabbit. Pt level in different organs and in urine was measured at regular intervals. Pt level in implanted muscles was higher in comparison to low serum level in mice. It was released slowly over 1 to 2 months in mice, whereas in rabbit it took about three weeks. Pt releasing period of the Plachitin was different according to the adopted method of implantation. Anticancer effect of Plachitin was investigated by injecting 180 sarcoma cells in mouse peritoneal cavity and subsequent implantation of Plachitin. In control groups chitin was used instead of Plachitin. The survival rate of mice in the Plachitin group after 14 days was higher than in the chitin group, and the anticancer effect of the Plachitin was confirmed.
Suzuki
K
K
2nd Dept. of Surgery, Shimane Medical University.
Nakamura
T
T
Tachibana
M
M
Koto
T
T
Yoshimura
H
H
Abe
S
S
Kifune
K
K
Tsurutani
R
R
Yoshimura
M
M
Nakamura
Y
Y
D000042:Absorption; D000117:Acetylglucosamine / Q000008:administration & dosage / Q000493:pharmacokinetics; D000818:Animals; D002686:Chitin; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D051379:Mice; D010984:Platinum / Q000097:blood; D011817:Rabbits; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D003692:Delayed-Action Preparations; D002686:Chitin; D010984:Platinum; D002945:Cisplatin; D000117:Acetylglucosamine