title: [Studies on the antitumor antibiotic aclacinomycin A].
abstract: During the course of screening for new antitumor antibiotics, a new anthracycline antibiotic--aclacinomycin A was separated from the broth and mycelium of Streptomyces AC-57. The strain AC-57 was isolated from the soil collected in the Shanghai suburbs. According to its culture and physiological characteristics the producer was identified as Str. galilaeus AC-57. The broth and mycelium were extracted and treated with solvents as usual way. The aclacinomycin A was separated by silica-gel column chromatography eluted with chrolo-form-methanol. Aclacinomycin A, its aglycone and sugar components were identified by comparison of their physico-chemical and spectral data (MS, UV, IR, 1H-NMR, and 13C-NMR) with authentic compound, purified from the market sample.
authors.affiliation: Shanghai Institute of Materia Medica, Academia Sinica, Shanghai.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Xu
authors.forename: Y
authors.initials: Y
authors.lastname: Ye
authors.forename: P
authors.initials: P
authors.lastname: Chen
mesh_terms: D015250:Aclarubicin / Q000096:biosynthesis* / Q000737:chemistry; D013302:Streptomyces / Q000302:isolation & purification* / Q000378:metabolism
chemical_list: D015250:Aclarubicin