[The dynamics of the body distribution of heparin and its antagonist, the quaternary ammonium salt of conidine oligomer-25, when administered via the lungs].
The distribution in the organism of radioactivity after intratracheal administration of labelled heparin and its quarterly ammonium salt oligomer-25 conidine was studied. Within 25 hours the preservation of a high level of radioactivity in plasma, its decrease in other investigated organs and the accumulation in mast cells of the peritoneal cavity were observed. The involvement of the lymphatic system in heparin metabolism was shown. A positively charged oligomer conidine administered intratracheally, in contrast to heparin, was not detected in blood plasma in the studied time. The accumulation of the drug in the lung tissue, lymph nodes and excretory organs was noted.
Rumiantsev
A G
AG
Golovleva
O A
OA
Rozkin
M Ia
MIa
Kazarian
V A
VA
Efimov
V S
VS
D000280:Administration, Inhalation; D000818:Animals; D002250:Carbon Radioisotopes; D006493:Heparin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006494:Heparin Antagonists / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D011108:Polymers / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D013462:Sulfur Radioisotopes; D013997:Time Factors; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D006494:Heparin Antagonists; D011108:Polymers; D013462:Sulfur Radioisotopes; C039164:conidine; D006493:Heparin
Issledovanie dinamiki raspredeleniia v organizme geparina i ego antagonista--chetvertichnoĭ ammoniĭnoĭ soli oligomera-25 konidina, vvedennykh cherez legkie.