title: Quantitative 99Tcm-HMPAO white blood cells and 67Ga scanning in rheumatoid arthritis.
abstract: This investigation assessed 99Tcm-HMPAO white blood cell (Tc-WBC) and 67Ga knee uptake indices before and after 90Y treatment in patients with intractable rheumatoid arthritis (RA) and correlated the uptake indices with the clinical score. Sixteen knee joints with RA were treated with intra-articular injection of 185 MBq of 90Y-silicate colloid (Amersham) flushed with 50 mg of hydrocortisone. Clinical score, quantitative 67Ga and Tc-WBC knee uptake indices were obtained before and three weeks after treatment. Our results showed that 9/16 (56%) had a good response and 7/16 (44%) had a poor response to 90Y injection. There was poor correlation between clinical improvement and changes in 67Ga and Tc-WBC knee uptake indices (r = 0.46 and 0.14, respectively). The correlation coefficient between changes in 67Ga and Tc-WBC knee uptake indices was 0.29.
authors.affiliation: Department of Nuclear Medicine, Veterans General Hospital, Taichung, Taiwan.
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
authors.forename: D U
authors.initials: DU
authors.lastname: Chen
authors.forename: M S
authors.initials: MS
authors.lastname: Lin
authors.forename: S H
authors.initials: SH
authors.lastname: Yeh
authors.forename: J L
authors.initials: JL
authors.lastname: Lan
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D005260:Female; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000378:metabolism; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D010091:Oximes / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
chemical_list: D005710:Gallium Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D015021:Yttrium Radioisotopes; D019690:Technetium Tc 99m Exametazime