title: Suicide on the paternal and maternal sides of depressed patients with a lifetime history of attempted suicide.
abstract: The computational model of Slater, based on the analysis of ancestral secondary cases on the paternal and maternal sides of the subjects, was applied to depressed patients with a lifetime history of attempted suicide, either violent or nonviolent, in order to investigate possible modes of transmission of suicidal behavior. Among 549 patients, 15 had 2 or more ascendant first- and second-degree relatives who committed suicide. The results of the distribution of these cases were compatible with polygenic inheritance of suicidal behavior in depressed patients with a history of attempted suicide. In patients using violent methods, a significantly greater loading of ancestral secondary cases of suicide was observed on the maternal side and, in the nonviolent attempter group, on the paternal side.
authors.affiliation: Department of Psychiatry, Athens University, Greece.
authors.forename: G N
authors.initials: GN
authors.lastname: Papadimitriou
authors.forename: P
authors.initials: P
authors.lastname: Linkowski
authors.forename: C
authors.initials: C
authors.lastname: Delarbre
authors.forename: J
authors.initials: J
authors.lastname: Mendlewicz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology; D016241:Child of Impaired Parents / Q000523:psychology*; D003866:Depressive Disorder / Q000235:genetics* / Q000523:psychology; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D006801:Humans; D008297:Male; D008426:Maternal Deprivation; D008875:Middle Aged; D008957:Models, Genetic; D010333:Paternal Deprivation; D010553:Personality Development; D012307:Risk Factors; D012931:Social Environment; D013405:Suicide / Q000523:psychology*; D013406:Suicide, Attempted / Q000523:psychology*; D014754:Violence