title: [The morphological characteristics of globulin production during the vaccinal process induced by tularemia and brucellosis vaccines].
abstract: Significant data on the dynamics of globulin production in guinea pigs in the process of immunogenesis after the injection of Francisella tularensis vaccine strain or conjugated brucellosis vaccine have been obtained by means of immunofluorescence and the enzyme immunoassay. The number of globulin-producing cells in lymphoid organs (the spleen, regional and remote lymph nodes) differs, depending on the injected antigen. The relationship between the character of immunomorphological changes in lymphoid organs and the dynamics of the increase of antibody titers in the peripheral blood of the animals after their immunization with conjugated brucellosis vaccine and the injection of avirulent F. tularensis has been established.
authors.forename: E P
authors.initials: EP
authors.lastname: Golubinskiĭ
authors.forename: I I
authors.initials: II
authors.lastname: Osipenko
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Solodun
authors.forename: P A
authors.initials: PA
authors.lastname: Manokhin
authors.forename: M P
authors.initials: MP
authors.lastname: Rudnik
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000917:Antibody Formation / Q000276:immunology; D000921:Antibody-Producing Cells / Q000166:cytology / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology*; D002004:Brucella Vaccine / Q000276:immunology*; D005604:Francisella tularensis / Q000276:immunology*; D006168:Guinea Pigs; D007107:Immune System / Q000166:cytology* / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis / Q000096:biosynthesis*; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D002004:Brucella Vaccine; D007136:Immunoglobulins
vernacular_title: Morfologicheskaia kharakteristika globulinproduktsii pri vaktsinal'nom protsesse, vyzvannom tuliaremiĭnoĭ i brutselleznoĭ vaktsinami.