[Dynamics of the immunohematologic indices in patients with acute III-IV degree radiation sickness in the post-pancytopenia period].
The paper is concerned with the results of determining the total number of lymphocytes, T-lymphocytes and their immunoregulatory subpopulations, B-lymphocyte of peripheral blood, serum IgA, IgG and IgM in 44 patients with ARS, II-IV degree at days 37-109 after the Chernobyl accident. Bone marrow transplantation was performed in all the patients not later than on the 14th day. Among lymphocytes, T-lymphocytes were shown to restore to normal first, the T-helpers/T-suppressors ratio being decreased. In 2 survivors this ratio remained decreased 2 mos. after the normalization of peripheral blood indices. Possibilities of correction of the revealed disorders with immunomodulators were discussed.
Kalinin
N L
NL
Kukharkova
T V
TV
Karpun
I I
II
Baranov
A E
AE
D000059:Accidents; D000328:Adult; D001402:B-Lymphocytes; D016026:Bone Marrow Transplantation; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009688:Nuclear Reactors; D011832:Radiation Injuries / Q000276:immunology* / Q000628:therapy; D016176:T-Lymphocyte Subsets; D013601:T-Lymphocytes; D013997:Time Factors; D014455:Ukraine
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Dinamika immunogematologicheskikh pokazateleĭ u bol'nykh ostroĭ luchevoĭ bolezn'iu III-IV stepeni v postpantsitopenicheskiĭ period.