[The convulsive activity of white rats after immunization with a conjugate of sidnofen and serum albumin].
The influence of white rats immunization by a covalent conjugate of serum albumin with sydnophen on the seizure activity in the single and repeated injections of pentylenetetrazole was investigated. The immunization lowered the seizure activity in single injections of threshold doses, (60 mg/kg) of pentylenetetrazole. The repeated daily injections of the drug in subthreshold doses (30 mg/kg) inhibited the process of "kindling" effects formation.
Danilova
R A
RA
Kustova
E V
EV
Obukhova
M F
MF
Ashmarin
I P
IP
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000276:immunology*; D007114:Immunization / Q000379:methods*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000276:immunology; D012709:Serum Albumin / Q000008:administration & dosage / Q000276:immunology*; D013558:Sydnones / Q000008:administration & dosage / Q000276:immunology*; D013997:Time Factors
D000928:Antidepressive Agents; D012709:Serum Albumin; D013558:Sydnones; C013271:sydnophen; D010433:Pentylenetetrazole
Sudorozhnaia aktivnost' belykh krys posle immunizatsii kon''iugatom sidnofena s serumal'buminom.