title: [A new approach to the search for antineoplastic compounds].
abstract: The necessity of using microbial test systems with regular reproduction of associated impairments in cell differentiation and division in screening of antitumor compounds is substantiated. Conditions for induction of such impairments during secondary growth in prokaryotic and eukaryotic mycelial microorganisms were developed. The fungal culture, Fusarium bulbigenum var. blasticola, the growth of whose secondary colonies was selectively inhibited by representatives of various classes of antitumor agents such as alkylating agents, antimetabolites, antibiotics, plant preparations, etc. was isolated.
authors.forename: E T
authors.initials: ET
authors.lastname: Nikitina
authors.forename: N A
authors.initials: NA
authors.lastname: Aĭtkhozhina
authors.forename: Sh Sh
authors.initials: ShSh
authors.lastname: Esenova
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D005057:Eukaryotic Cells / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects / Q000302:isolation & purification; D011387:Prokaryotic Cells / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic
vernacular_title: Novyĭ podkhod k poisku protivoopukholevykh soedineniĭ.