title: Development of early and late brainstem conduction time in normal and intrauterine growth retarded children.
abstract: Development of early (I-III) and late (III-V) brainstem conduction time (BCT) in the brainstem auditory evoked responses was examined and compared in 178 appropriate-for-gestational-age (AGA) and 24 small-for-gestational-age (SGA) children from birth to 6 years of age. In AGA children, the III-V/I-III interval ratio increased with age from birth to 2 years and remained relatively steady. This indicates that the development of the early and late BCT, or probably the lower and upper brainstem is not synchronous during early childhood, with a slightly faster development of the early BCT relative to the late BCT. In SGA children, the I-V, I-III and III-V intervals showed similar developmental trends to those in AGA children. However, the III-V/I-III ratio followed a developmental course which differed remarkably from that in AGA children. The ratio decreased slightly with age up to 2 years and was consistently smaller than in normal children after 1 year, indicating that the relative development of early and late BCT deviates from normal. This finding suggests that prenatal factors responsible for intrauterine growth retardation could alter the late or long-term development of the nervous system, resulting in sub-optimal outcome.
authors.affiliation: Department of Child Health, Children's Hospital, Shanghai Medical University, China.
authors.forename: Z D
authors.initials: ZD
authors.lastname: Jiang
authors.forename: Y Y
authors.initials: YY
authors.lastname: Wu
authors.forename: M S
authors.initials: MS
authors.lastname: Zhen
authors.forename: D K
authors.initials: DK
authors.lastname: Sun
authors.forename: L Y
authors.initials: LY
authors.lastname: Feng
authors.forename: Y M
authors.initials: YM
authors.lastname: Peng
authors.forename: X Y
authors.initials: XY
authors.lastname: Liu
mesh_terms: D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D012016:Reference Values; D013997:Time Factors