1,25-Dihydroxycholecalciferol inhibits the cochemotactic activity of Gc (vitamin D binding protein).
The identification of Gc (vitamin D binding protein) with the anionic polypeptide cochemotaxin has recently been reported. In this paper we investigate its dose dependent cochemotactic activity and report the inhibition of Gc enhanced chemotaxis by vitamin D3. These results further support the role of immunomodulating hormone played by vitamin D.
Petrini
M
M
Servizio di Ematologia, Università di Pisa, Italy.
Azzarà
A
A
Carulli
G
G
Grassi
B
B
Ambrogi
F
F
Galbraith
R M
RM
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D002117:Calcitriol / Q000494:pharmacology* / Q000502:physiology; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology; D002633:Chemotaxis / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D014809:Vitamin D-Binding Protein / Q000502:physiology*
D000276:Adjuvants, Immunologic; D014809:Vitamin D-Binding Protein; D002117:Calcitriol