[Comparative evaluation of 2 schedules of administration of anti- neoplastic drugs by the CMF protocol in disseminated breast cancer].
Combined chemotherapy with cyclophosphamide, methotrexate, fluorouracil (CMF) in two regimens of administration was comparatively assessed in a randomized and prospective trial. Group I patients (n = 34) received methotrexate and fluorouracil once a week and cyclophosphamide every other day for 15 days. In group II (n = 32) all the drugs were given simultaneously once weekly for 15 days. A complete and partial response occurred significantly more frequently in patients of group I (36%) versus group II (7%). The intergroup difference in toxicity appeared insignificant.
Korman
D B
DB
Snimshchikov
V A
VA
Dobroskok
L B
LB
Maslova
I A
IA
Mikaélian
S G
SG
Pines
E V
EV
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000556:secondary; D008727:Methotrexate / Q000008:administration & dosage; D011446:Prospective Studies; D012074:Remission Induction
D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate
Sravnitel'naia otsenka dvukh rezhimov vvedeniia protivoopukholevykh preparatov po skheme CMF pri disseminirovannom rake molochnoĭ zhelezy.