Adult polycystic kidney disease in a kindred of West Indian origin exhibits linkage with the 3'HVR probe on chromosome 16.
In a large pedigree of Caribbean origin with adult polycystic kidney disease, linkage has been established to the 3'HVR probe on chromosome 16. Although there are five different fathers in this pedigree, only one of whom was available for DNA analysis, the polymorphic nature of 3'HVR has enabled gene tracking to be carried out. The same allele cosegregates with the disease in every affected family member.
Jeffery
S
S
S W Thames Regional Genetics Service, St George's Hospital Medical School, London.
Wing
A J
AJ
Patton
M
M
D000328:Adult; D000483:Alleles; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D005260:Female; D006801:Humans; D008126:Lod Score; D008131:London; D008297:Male; D010375:Pedigree; D007690:Polycystic Kidney Diseases / Q000208:ethnology / Q000235:genetics*; D014900:West Indies / Q000208:ethnology
D015342:DNA Probes; D004247:DNA