Response of three hormones to diazepam challenge in sons of alcoholics and controls.
This study evaluates the hypothesis that the decreased reaction to ethanol reported for sons of alcoholics will also be observed following infusions of a benzodiazepine. The investigation compared 37 men who were family history positive for alcoholism with 37 family history negative controls on postinfusion levels of cortisol, prolactin, and growth hormone following 0.12 and 0.20 mg/kg of diazepam given IV over 7 minutes. The results demonstrated no evidence of a decreased response for the sons of alcoholics on the levels of these three hormones.
Schuckit
M A
MA
School of Medicine, University of California-San Diego.
Hauger
R L
RL
Monteiro
M G
MG
Irwin
M
M
Duthie
L A
LA
Mahler
H I
HI
D000328:Adult; D000428:Alcohol Drinking / Q000097:blood / Q000235:genetics; D000437:Alcoholism / Q000097:blood / Q000235:genetics*; D003975:Diazepam; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011388:Prolactin / Q000097:blood*; D012307:Risk Factors
D011388:Prolactin; D013006:Growth Hormone; D003975:Diazepam; D006854:Hydrocortisone