Sleepiness/alertness on a simulated night shift following sleep at home with triazolam.
Physiological sleep tendency during a simulated night shift schedule was examined in 15 middle-aged subjects following daytime sleep after administration of triazolam or placebo. A double-blind, counterbalanced, crossover design involving two tours of five laboratory nights and four daytime home sleep periods was used. Triazolam lengthened daytime sleep as measured by wrist actigraph and improved nighttime alertness as measured by the MSLT. Sleepiness was most profound during the early morning hours (0430 to 0630) but improved significantly across nights for both conditions. Repeated test of sustained wakefulness latencies and simulated assembly line task performance decreased slightly across the night, but there were no significant condition effects. Subjective data tended to support objective measures, although Stanford Sleepiness Scale ratings indicated that subjects did not perceive improved alertness at night after triazolam-aided daytime sleep.
Walsh
J K
JK
Sleep Disorders and Research Center, Deaconess Hospital, St. Louis, Missouri 63139.
Schweitzer
P K
PK
Anch
A M
AM
Muehlbach
M J
MJ
Jenkins
N A
NA
Dickins
Q S
QS
D000328:Adult; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D014229:Triazolam / Q000008:administration & dosage / Q000494:pharmacology*; D014851:Wakefulness / Q000187:drug effects*; D014940:Work Schedule Tolerance
D010919:Placebos; D014229:Triazolam