Tobacco-specific N-nitrosamines in tobacco and mainstream smoke of Indian cigarettes.
Different brands of Indian cigarettes were analysed, by gas chromatography-thermal energy analysis, for the presence of carcinogenic tobacco-specific N-nitrosamines (TSNA) in both tobacco and mainstream smoke. Preformed TSNA in cigarette tobacco ranged between 68 and 730 ng N-nitrosonornicotine (NNN)/cigarette, between 19 and 174 ng 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)/cigarette and between 98 and 519 ng N-nitrosoanabasine (NAB) together with N-nitrosoanatabine (NAT)/cigarette. The amounts of NNN, NNK and NAB/NAT in mainstream smoke were 11-156, 7-73 and 17-146 ng/cigarette, respectively.
Kumar
R
R
Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, Jammu, India.
Siddiqi
M
M
Tricker
A R
AR
Preussmann
R
R
D002849:Chromatography, Gas / Q000379:methods; D007194:India; D009566:Nitrates / Q000032:analysis; D009602:Nitrosamines / Q000032:analysis*; D010947:Plants, Toxic; D012906:Smoke / Q000032:analysis*; D014026:Nicotiana / Q000032:analysis*
D009566:Nitrates; D009602:Nitrosamines; D012906:Smoke