Susceptibility of iron-loaded Borrelia burgdorferi to killing by hydrogen peroxide and human polymorphonuclear leucocytes.
Borrelia burgdorferi grew more slowly in iron-depleted than in iron-sufficient media. The addition of increasing concentrations of iron stimulated borrelial growth and resulted in the intracellular accumulation of this element. Compared with iron-starved borrelia, iron-enriched organisms showed enhanced sensitivity to hydrogen peroxide. Intracellular iron-content did not, however, influence susceptibility to killing by human polymorphonuclear leucocytes [corrected].
Sambri
V
V
Institute of Microbiology, University of Bologna, S. Orsola Hospital, Italy.
Cevenini
R
R
La Placa
M
M
D001770:Blood Bactericidal Activity; D015748:Borrelia burgdorferi Group / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D003470:Culture Media; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology*; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis
D003470:Culture Media; D006861:Hydrogen Peroxide; D007501:Iron