title: Rapidly progressive squamous cell carcinoma of the cervix coexisting with human immunodeficiency virus infection: clinical opinion.
abstract: The acquired immune deficiency syndrome (AIDS) has been characterized by aggressive malignancies and infections with unusual presentations. There is a well-documented association between cervical dysplasia and the development of cervical carcinoma, and more recent evidence of an association between cervical dysplasia and HIV infection. The course of coexistent HIV infection and cervical cancer has not been well described. We report a patient with HIV infection and a stage IIIB squamous cell carcinoma of the cervix who, despite adequate treatment, had rapid disease progression as well as metastasis to an unusual iliopsoas muscle site in association with an abscess. As HIV becomes more prevalent in the female population, an increased frequency of rapidly progressive cervical carcinoma may be forthcoming. Improved life expectancy of HIV-infected patients due to modern medication is anticipated, causing a cervical neoplasm to have a more prominent effect on prognosis. Close surveillance with frequent Pap smears and colposcopies as well as aggressive management of cervical dysplasia and carcinoma in HIV-infected patients is suggested as is thorough patient counseling.
authors.affiliation: Department of Obstetrics and Gynecology, Yale-New Haven Hospital, Connecticut 06510.
authors.forename: L B
authors.initials: LB
authors.lastname: Schwartz
authors.forename: M L
authors.initials: ML
authors.lastname: Carcangiu
authors.forename: L
authors.initials: L
authors.lastname: Bradham
authors.forename: P E
authors.initials: PE
authors.lastname: Schwartz
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000473:pathology; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000473:pathology