Fluvirucins A1, A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza A virus. I. Production, isolation, chemical properties and biological activities.
Five unidentified actinomycete strains produced a series of novel antiviral antibiotics which have a unique 2,6-dialkyl-10-ethyl-3(or 9)-hydroxy-13-tridecanelactam nucleus substituted with 3-amino-3,6-dideoxy-L-talose or 3-amino-3,6-dideoxy-L-mannose(L-mycosamine). The antibiotic components exhibited potent inhibitory activity against influenza virus type A Victoria strain infection in Madin Darby canine kidney cells by the cytopathic effect reduction assay.
Naruse
N
N
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Tenmyo
O
O
Kawano
K
K
Tomita
K
K
Ohgusa
N
N
Miyaki
T
T
Konishi
M
M
Oki
T
T
D000192:Actinomycetales / Q000145:classification / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003837:Deoxy Sugars / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004285:Dogs; D005285:Fermentation; D009980:Influenza A virus / Q000187:drug effects*; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D003837:Deoxy Sugars; D007769:Lactams