title: Sensori-neural hearing loss in patients treated with irradiation for nasopharyngeal carcinoma.
abstract: The present investigation has been carried out to evaluate the sensitivity of the inner ear to irradiation. Cochlear function was tested in a cohort of 22 patients before and 7-84 months after receiving external irradiation for nasopharyngeal carcinoma. The pre-irradiation sensori-neural hearing threshold at 500, 1000, 2000, and 4000 Hz was used as a baseline for the individual patient, and the observed sensori-neural hearing loss (SNHL) was calculated as the difference between pre- and post-irradiation values. The pre-irradiation hearing level or patient age was not correlated with the actual SNHL. In contrast, there was a significant correlation between the total radiation dose to the inner ear and the observed hearing impairment. SNHL was most pronounced in the high frequencies, with values up to 35 dB (4000 Hz) and 25 dB (2000 Hz) in some patients. The latent period for the complication appeared to be 12 months or more. The deleterious effect of irradiation on the hearing should be kept in mind both in treatment planning and in the follow-up after radiotherapy.
authors.affiliation: Department of Oto-rhino-laryngology and Audiology, University of Aarhus, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Grau
authors.forename: K
authors.initials: K
authors.lastname: Møller
authors.forename: M
authors.initials: M
authors.lastname: Overgaard
authors.forename: J
authors.initials: J
authors.lastname: Overgaard
authors.forename: O
authors.initials: O
authors.lastname: Elbrønd
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors