Cellular aging and senescence.
Differentiated eukaryotic cells have only a finite capacity for cell division. This limitation is thought to be a cellular manifestation of organismal aging, and a restraint to tumor progression. The molecular basis for cellular senescence is not known, but a molecular framework for understanding this phenomenon has recently been established.
McCormick
A
A
Biology of Aging Program, National Institute of Aging, Bethesda, Maryland 20892.
Campisi
J
J
D000818:Animals; D002455:Cell Division; D002470:Cell Survival / Q000235:genetics*; D006801:Humans