Prophylactic use of a single dose of tobramycin in elective colorectal surgery.
The aim of this prospective study is to acquire clinical experience with a single high dose of tobramycin in prophylactic use. Sixty three patients undergoing elective colorectal surgery, were assigned to receive antibiotic prophylaxis (24 hours perioperatively) in the form of a single high dose of tobramycin and a classically recommended thrice-a-day (TID) administration of clindamycin. The planned dose for tobramycin was 3.3 mg/kg/day. Adjustment was made in case of impaired renal function. Serum levels of the drug were monitored. The results showed well predictable levels. Six out of fifty five evaluable patients (10.9%) presented postoperative infectious complications within the follow up period. No renal nor otovestibular toxicity was recorded.
Vanderveken
M
M
Department of General Surgery, General Hospital Middelheim, Antwerp, Belgium.
Schepens
M
M
Gerard
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002981:Clindamycin / Q000627:therapeutic use; D003108:Colonic Diseases / Q000601:surgery*; D003404:Creatinine / Q000097:blood; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011183:Postoperative Complications; D011292:Premedication; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000209:etiology; D014031:Tobramycin / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood
D002981:Clindamycin; D003404:Creatinine; D014031:Tobramycin