Localization of the HST/FGFK gene with regard to 11q13 chromosomal breakpoint and fragile site.
The HST/FGFK gene, a member of the fibroblast growth factor gene family and a protooncogene, is localized on chromosomal band 11q13. Genes in this region are frequently involved in hematopoietic and solid tumors. Here we show that the HST gene lies telomeric to the BCL1 gene, the t(11;14)(q13;q32) breakpoint, and the FRA11A rare fragile site.
Hagemeijer
A
A
Erasmus University, Rotterdam, The Netherlands.
Lafage
M
M
Mattei
M G
MG
Simonetti
J
J
Smit
E
E
de Lapeyriere
O
O
Birnbaum
D
D
D002871:Chromosome Banding; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D051522:Fibroblast Growth Factor 6; D005346:Fibroblast Growth Factors / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015463:Leukemia, Prolymphocytic / Q000235:genetics* / Q000473:pathology; D008297:Male; D008677:Metaphase; D008875:Middle Aged; D005810:Multigene Family; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D014178:Translocation, Genetic
C496452:FGF6 protein, human; D051522:Fibroblast Growth Factor 6; D011518:Proto-Oncogene Proteins; D005346:Fibroblast Growth Factors