Formamidines with antinociceptive and antiinflammatory activities.
Pursuing our investigations on 7-amino-2,3-polymethyleneindole derivatives, a set of 7-(dimethylaminomethylene)-amino-2,3-polymethyleneindoles, together with some other aryl or cycloalkyl substituted formamidines, were prepared and tested for analgesic and antiinflammatory activities. Several compounds resulted endowed with one or both of these activities; the indole derivatives 1 and 2 exhibited a good degree of both of them.
Cerri
R
R
Istituto di Analitica Farmaceutica, Università di Sassari, Italy.
Boatto
G
G
Pau
A
A
Sparatore
F
F
Cima
L
L
Carrara
M
M
Satta
M
M
D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D016227:Benzoquinones; D002351:Carrageenan; D004487:Edema / Q000517:prevention & control; D005260:Female; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains
D000578:Amidines; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016227:Benzoquinones; C029322:phenylbenzoquinone; D002351:Carrageenan