Post-transfusion purpura as the main manifestation of a trilineal transfusion reaction, responsive to steroids: flow-cytometric investigation of granulocyte and platelet antibodies.
We report a typical case of post-transfusion purpura (PTP) due to anti-PlA1 in a 65-year-old woman. Serological studies were carried out using flow cytometry (FCM). The patient also developed red cell alloantibodies that produced a delayed hemolytic transfusion reaction (DHTR) and broad HLA antibodies. Treatment with high-dose intravenous IgG (HDIgG; a first-generation preparation) was ineffective, but a course of steroids resulted in a rapid increase in the the platelet count.
Puig
N
N
Center of Transfusion of Comunidad Valenciana, Valencia, Spain.
Sayas
M J
MJ
Montoro
J A
JA
Villalba
J V
JV
Pla
A
A
D000368:Aged; D000906:Antibodies / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005434:Flow Cytometry; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage; D008775:Methylprednisolone / Q000627:therapeutic use; D011693:Purpura / Q000188:drug therapy / Q000209:etiology*; D065227:Transfusion Reaction
D000906:Antibodies; D007074:Immunoglobulin G; D008775:Methylprednisolone