Topical application of superoxide dismutase cream.
A superoxide dismutase (SOD) cream containing 0.6 mg/ml of bovine SOD was prepared. It was applied locally onto the skin and mucosal lesions caused by progressive systemic sclerosis (PSS), systemic lupus erythematosus (SLE), Behçet's disease, herpes simplex and burns. The lesions and symptoms were rapidly improved in many cases after its administration, even when the symptoms were stabilized for several weeks before the treatment. Although the trial was open-labelled, the topical application of SOD was concluded to be effective for these conditions.
Mizushima
Y
Y
Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan.
Hoshi
K
K
Yanagawa
A
A
Takano
K
K
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000188:drug therapy*; D002056:Burns / Q000188:drug therapy*; D002648:Child; D003095:Collagen Diseases / Q000188:drug therapy*; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects; D013482:Superoxide Dismutase / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use
D013482:Superoxide Dismutase