Hyporegenerative anemia associated with intrauterine transfusion in rhesus hemolytic disease.
Serial erythropoietin and ferritin levels were monitored in a fetus and newborn requiring three intravascular transfusions (in utero) for severe Rh disease. The newborn had a hematocrit of 37% at birth; however a hyporegenerative transfusion-dependent anemia developed and lasted approximately 3 months. The prolonged hyporegenerative anemia may be caused in part by erythropoietin suppression as a result of the fetal intravascular transfusions. In addition, anti-D antibody may also contribute to this anemia by a direct toxic effect on erythroid precursors and by peripheral hemolysis of reticulocytes.
Thorp
J A
JA
St. Luke's Perinatal Center, St. Luke's Hospital, Kansas City, MO 64111.
O'Connor
T
T
Callenbach
J
J
Cohen
G R
GR
Yeast
J D
JD
Albin
J
J
Plapp
F
F
D000328:Adult; D000740:Anemia / Q000097:blood / Q000209:etiology* / Q000628:therapy; D001803:Blood Transfusion; D001805:Blood Transfusion, Intrauterine / Q000009:adverse effects*; D002452:Cell Count; D004899:Erythroblastosis, Fetal / Q000628:therapy*; D004921:Erythropoietin / Q000032:analysis; D005260:Female; D006400:Hematocrit; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D012156:Reticulocytes / Q000473:pathology
D004921:Erythropoietin