title: In vitro/in vivo evaluation of hydrochlorothiazide in experimental hydrochlorothiazide/triamterene combination tablets in beagle dogs.
abstract: The purpose of this study was to compare experimental formulations containing hydrochlorothiazide (CAS 58-93-5)/triamterene (HCT/TRI) in vitro and in vivo to a commercial tablet formulation (standard). The beagle dog was verified as a good model and was used for the in vivo studies. The commercial tablet and the experimental fast release formulation (FR) resulted in 100% release of HCT within 30 min in dissolution tests, whereas, the slow release formulation (SR) released only 54% HCT after 4 h. Relative bioavailability of the FR and SR formulations were 82 and 41%, respectively, compared to the commercial tablet. The experimental results indicate that HCT absorption occurs throughout the small intestine.
authors.affiliation: Division of Pharmaceutics and Drug Delivery Systems, College of Pharmacy, University of Cincinnati Medical Center.
authors.forename: W A
authors.initials: WA
authors.lastname: Ritschel
authors.forename: M
authors.initials: M
authors.lastname: Turkoglu
authors.forename: D
authors.initials: D
authors.lastname: Lipps
authors.forename: A
authors.initials: A
authors.lastname: Warner
authors.forename: A
authors.initials: A
authors.lastname: Sakr
mesh_terms: D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007202:Indicators and Reagents; D008297:Male; D012995:Solubility; D013607:Tablets; D014223:Triamterene / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D003692:Delayed-Action Preparations; D004338:Drug Combinations; D007202:Indicators and Reagents; D013607:Tablets; D006852:Hydrochlorothiazide; D014223:Triamterene