Easy and practical utilization of CONSAM for simulation, analysis, and optimization of complex dosing regimens.
Complex dosing regimens simulated in the literature using a universal dosing regimen were calculated with a general dosing program developed using the program CONSAM. The program provides a rapid method of calculating nonuniform dosing regimens for up to n = 3 compartments for any linear model. Subject data can also be curve fitted with the program to obtain individual subject estimates to allow for dosage optimization, which is important in a clinical setting. Examples are presented to show the use of the program in optimizing a theophylline regimen, as well as estimation of a new parameter, Cuneq(T), which is defined as the average non-steady-state drug concentration at time t for a drug with an irregular dosing interval.
Jackson
A J
AJ
Division of Bioequivalence, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857.
Zech
L A
LA
D003198:Computer Simulation; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D004360:Drug Therapy, Computer-Assisted; D008954:Models, Biological; D010599:Pharmacokinetics; D012984:Software; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics
D003692:Delayed-Action Preparations; D013806:Theophylline