title: Tapia's syndrome caused by Paracoccidioidis brasiliensis.
abstract: Tapia's syndrome is due to extracranial involvement of the XIIth nerve and the recurrent laryngeal branch of the Xth nerve. There is ipsilateral paralysis of vocal cords, soft palate and tongue. The main causes are parotid and other tumors or injuries to the high neck. We describe here a Brazilian female patient who presented with a lesion in the nasal mucosa, and soon after had dysphagia and dysphonia. Examination revealed paralysis of the soft palate, vocal cords and tongue ipsilaterally. Microscopic examination of the lesion in the nasal mucosa revealed the presence of the fungus. The patient was treated with sulfonamide and ketoconasol.
authors.affiliation: Department of Clinical Medicine (Neurology), Hospital Universitário Antonio Pedro, Rio de Janeiro, Brazil.
authors.forename: M R
authors.initials: MR
authors.lastname: de Freitas
authors.forename: O J
authors.initials: OJ
authors.lastname: Nascimento
authors.forename: L
authors.initials: L
authors.lastname: Chimelli
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007002:Hypoglossal Nerve; D007654:Ketoconazole / Q000627:therapeutic use; D009297:Nasal Mucosa / Q000382:microbiology; D010229:Paracoccidioidomycosis / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D010243:Paralysis / Q000382:microbiology* / Q000503:physiopathology; D013577:Syndrome; D014630:Vagus Nerve
chemical_list: D007654:Ketoconazole