[The effect of diabetogenic substances on the zinc and calcium content in the pancreatic islet cells of rabbits].
The injections of diabetogenic drugs to rabbits induced a decrease in zinc and calcium content in B insulocytes dependent on the degree of these cells damage and hyperglycemia. The content of these metals in A insulocytes was not significantly altered due to a light injury of these cells. A high concentration of calcium in islet A cells is suggested to be a protective factor to the action of alteration agents.
Gol'dberg
E D
ED
Eshchenko
V A
VA
Bovt
V D
VD
D000634:Aminoquinolines / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000378:metabolism; D004230:Dithizone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006651:Histocytochemistry; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D013449:Sulfonamides / Q000494:pharmacology*; D014105:Tosyl Compounds; D015032:Zinc / Q000378:metabolism*; D000096926:Benzenesulfonamides
D000634:Aminoquinolines; D002118:Calcium; D004230:Dithizone; D013449:Sulfonamides; D014105:Tosyl Compounds; D015032:Zinc; C031480:8-(4-tolylsulfonylamino)quinoline; C031479:8-(4-benzenesulfonylamino)quinoline; D000096926:Benzenesulfonamides
Vliianie diabetogennykh veshchestv na soderzhanie tsinka i kal'tsiia v kletkakh pankreaticheskikh ostrovkov u krolikov.