title: [Clinical significance of urinary FDP-E measured by latex photometric immunoassay (LPIA) in the renal disease].
abstract: It is well known that urinary FDP is one of the parameters of intrarenal coagulation in renal disease. The measurement of urinary FDP, however, is not satisfactory enough, since it is not a quantitative and sensitive method. Latex photometric immunoassay has recently been developed as a quantitative and more sensitive method. Since fibrinogen reacts with FDP-E less than FDP, the measurement of urinary FDP-E is much better than that of urinary FDP in order to determine the presence of intrarenal coagulation and fibrinolysis of patients with renal diseases. The aim of this study is to clarify the clinical significance of urinary FDP-E measured by LPIA in the renal disease. The results were as follows: (1) Urinary FDP-E correlate with urinary protein, FDP, FDP-D, fibrinopeptide A (FPA), but not serum FDP-E. (2) The diseases which showed higher amounts of urinary FDP-E were diabetic nephropathy, amyloidosis and chronic glomerulonephritis. On the other hand, the diseases which showed smaller amounts of urinary FDP-E were minimal change, toxemia of pregnancy and lupus nephritis. All patients with higher amounts of urinary FDP-E showed marked renal dysfunction. But all the patients with the marked renal dysfunction did not always show higher amounts of urinary FDP-E. The urinary FDP-E showed a positive correlation to 1/serum creatinine. These results suggested that the measurement of urinary FDP-E is a useful method in determining the presence and degree of intrarenal coagulation and fibrinolysis in renal diseases.
authors.affiliation: Kidney Center, Univ. of Occupational and Environmental Health School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Kaizu
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Uriu
authors.forename: N
authors.initials: N
authors.lastname: Komine
authors.forename: O
authors.initials: O
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Eto
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000652:urine*; D006801:Humans; D007674:Kidney Diseases / Q000652:urine*; D007841:Latex Fixation Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D003404:Creatinine