The validation of freely diffusible tracer methods with NMR detection for measurement of blood flow.
While the general theory of measuring organ perfusion using exogenously administered freely diffusible tracers was originally formulated over 40 years ago, the application of NMR techniques for tracer detection is a recent development. A brief theoretical review and discussion of the literature validating the use of deuterium and fluorine as NMR-detectable tracers is provided.
Neil
J J
JJ
Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110.
D001775:Blood Circulation / Q000502:physiology*; D003903:Deuterium; D004058:Diffusion; D005461:Fluorine; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D014018:Tissue Distribution
D005461:Fluorine; D003903:Deuterium