[Free fatty acid spectrum and rheological properties of erythrocytes in people with disturbed glucose tolerance and in patients with diabetes mellitus].
The paper is devoted to a study of mechanisms of deterioration of blood rheological properties in disturbed carbohydrate metabolism in 17 patients with disorders in GTT and in 83 patients with diabetes mellitus (DM). The level of lipids, the spectrum of fatty acids (SFA) were determined in the blood plasma using gas chromatography by an original method, proposed by the authors for assessment of the rheological properties of erythrocytes (rotation viscosimetry of erythrocyte suspension in standard hematocrit of 45%). The concentrations of saturated and polyunsaturated acids in the blood plasma of persons with disturbed GTT and DM were increased, and the concentration of linoleic acid was lowered. More noticeable changes were observed in insulin dependent DM. A simultaneous increase in the viscosity of erythrocyte suspension at low rates of a shift in the DM group and change of the spectrum of fatty acids were revealed. Changes in the plasma SFA composition can be one of the causes of deteriorated rheological properties of erythrocytes.
Galenok
V A
VA
Dikker
V E
VE
Gostinskaia
E V
EV
Zykov
A A
AA
Khanykina
I V
IV
D000328:Adult; D001809:Blood Viscosity / Q000502:physiology*; D003920:Diabetes Mellitus / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged
D005230:Fatty Acids, Nonesterified
Spektr svobodnykh zhirnykh kislot i reologicheskie svoĭstva éritrotsitov u lits s narushennoĭ tolerantnost'iu k gliukoze i u bol'nykh sakharnym diabetom.