Lysophosphatidylcholine as a possible second messenger synergistic to diacylglycerol and calcium ion for T-lymphocyte activation.
An immediate reaction product of phosphatidylcholine hydrolysis catalyzed by phospholipase A2, lysophosphatidylcholine (lysoPC), synergizes with a membrane-permeable diacylglycerol, 1,2-dioctanoylglycerol, and ionomycin to activate resting T-lymphocytes as measured by interleukin-2 alpha-receptor expression. It is suggestive that both phospholipase C and phospholipase A2 are directly involved in signal transduction in a synergistic fashion and that lysoPC acts as an additional second messenger for cellular regulation, probably for long-term responses such as cell proliferation and differentiation.
Asaoka
Y
Y
Biosignal Research Center, Kobe University, Japan.
Oka
M
M
Yoshida
K
K
Nishizuka
Y
Y
D002118:Calcium / Q000502:physiology*; D002478:Cells, Cultured; D004261:DNA Replication; D004075:Diglycerides / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D004357:Drug Synergism; D006801:Humans; D015759:Ionomycin / Q000494:pharmacology; D007700:Kinetics; D008213:Lymphocyte Activation; D008244:Lysophosphatidylcholines / Q000378:metabolism*; D010741:Phospholipases A / Q000494:pharmacology; D054467:Phospholipases A2; D015375:Receptors, Interleukin-2 / Q000235:genetics; D015290:Second Messenger Systems; D015398:Signal Transduction / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D004075:Diglycerides; D008244:Lysophosphatidylcholines; D015375:Receptors, Interleukin-2; C044295:1,2-dioctanoylglycerol; D015759:Ionomycin; D010741:Phospholipases A; D054467:Phospholipases A2; D002118:Calcium