Suppression of lymphocyte blastogenesis by porcine interferon-alpha.
Peripheral blood lymphocytes (PBL) from five four-day-old and five six-week-old piglets were treated with 10 to 320 units of porcine interferon-alpha, and their blastogenic responses to phytohaemagglutinin or pokeweed mitogen were compared with those of control lymphocytes. There was significant inhibition of the blastogenic response to phytohaemagglutinin by 320 units of interferon-alpha, and of the response to pokeweed mitogen by 320 and 160 units of interferon-alpha. Porcine interferon-beta was cytotoxic to porcine PBL. The blastogenic response to pokeweed mitogen was significantly higher in PBL from the younger piglets.
Derbyshire
J B
JB
Department of Veterinary Microbiology and Immunology, University of Guelph, Canada.
De Laat
A
A
D000818:Animals; D000833:Animals, Suckling / Q000276:immunology*; D007370:Interferon Type I / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013552:Swine / Q000276:immunology*; D014886:Weaning
D007370:Interferon Type I; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens