A rapid method for evaluation of analgesic and anti-inflammatory activity in rats.
Carrageenin (2%) was used to produce edema and hyperalgesia; indomethacin, phenylbutazone, aspirin, ibuprofen, analgin, paracetamol and phenacetin were tested at different doses for anti-inflammatory and analgesic activity in the same rats as the peak for the edema reached at the end of 3rd hr and for the hyperalgesia at the end of 4th hr. Indomethacin, phenylbutazone and ibuprofen reduced edema and increased the pain threshold. Analgin and aspirin increased the pain threshold relatively at a low dose. Paracetamol and phenacetin were inactive in the doses tested. Carrageenin (2%) was observed to possess both phlogistic and allogenic properties.
Rao
C S
CS
Department of Pharmacology, IDPL Research Centre, Hyderabad, India.
Muralidhar
N
N
Naidu
M U
MU
Junnarkar
A Y
AY
Singh
P P
PP
D000700:Analgesics / Q000032:analysis*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004487:Edema / Q000139:chemically induced; D006930:Hyperalgesia / Q000139:chemically induced; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D000893:Anti-Inflammatory Agents