Hepatic fibrin-ring granulomas: a clinicopathologic study of 23 patients.
Twenty-three patients with characteristic hepatic fibrin-ring granulomas were studied. Q fever accounted for 10 cases (43%), visceral leishmaniasis for five cases (22%), boutonneuse fever for two cases (9%), and toxoplasmosis, Hodgkin's disease, and allopurinol hypersensitivity for one case each (4%). The etiology remained undetermined in three cases (13%). This report broadens the range of etiologies of hepatic fibrin-ring granulomas to include boutonneuse fever and toxoplasmosis in the differential diagnosis of ring granulomas, and it could serve as a guideline to the clinician and pathologist for the most frequent categories of disease associated with this morphologic pattern.
Marazuela
M
M
Hospital Puerta de Hierro, Madrid, Spain.
Moreno
A
A
Yebra
M
M
Cerezo
E
E
Gómez-Gesto
C
C
Vargas
J A
JA
D000328:Adult; D000368:Aged; D001907:Boutonneuse Fever / Q000150:complications; D002675:Child, Preschool; D005260:Female; D006099:Granuloma / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000150:complications; D008107:Liver Diseases / Q000209:etiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011778:Q Fever / Q000150:complications