[The effect of menatetrenone on peritoneal adhesion].
The correlation between the dose of menatetrenone and the incidence of post-laparotomy peritoneal adhesion in Ryan's model was investigated with the use of rats. In the menatetrenone treated group, the menatetrenone was intramuscularly given in a dosage of 10 mg immediately after closure of the abdominal wound and every 24 hours for two days. In this group, the incidence of ceco-colonic adhesion was 54% (20/37), whereas the incidence in non-treated group was 26% (10/39) (p less than 0.012). Especially in cases with an air-drying time of 1-2 minutes, the difference between incidences of ceco-colonic adhesion in the menatetrenone and that of the non-treated group was high. The former incidence was 61% (17/28) and that of the latter was 21% (6/29) (p less than 0.01). In addition, the incidence of peritoneal adhesion was proportionally dose-dependent to the menatetrenone. In our clinical retrospective study, the incidence of post-gastrectomy adhesive ileus increased with menatetrenone treatment to a significant degree. It is concluded that prophylactic administration of a large dose of menatetrenone should be avoided, because the incidence of post-laparotomy peritoneal adhesion could be increased.
Okino
M
M
First Department of Surgery, Yamaguchi University School of Medicine, Ube, Japan.
Tomie
H
H
Kanesada
H
H
Marumoto
M
M
Morita
N
N
Esato
K
K
D000818:Animals; D006490:Hemostatics / Q000009:adverse effects*; D007410:Intestinal Diseases / Q000209:etiology*; D007415:Intestinal Obstruction / Q000209:etiology; D008297:Male; D010532:Peritoneal Diseases / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains; D000267:Tissue Adhesions; D014812:Vitamin K / Q000009:adverse effects / Q000031:analogs & derivatives*; D024482:Vitamin K 2 / Q000031:analogs & derivatives
D006490:Hemostatics; D024482:Vitamin K 2; D014812:Vitamin K; C030814:menatetrenone