title: Effect of a taurine-supplemented diet on conjugated bile acids in biliary surgical patients.
abstract: The effect of a taurine-supplemented diet on the level of conjugated bile acids in postoperative patients was investigated during two consecutive 5-day period. Eighteen hepatobiliary patients with choledochostomies and a specific T-tube insertion were collected and divided randomly into two groups. In group 1, an ordinary postoperative soft diet was prescribed for the first 5 postoperative days and then followed with a taurine-supplemented soft diet (40 mumol/kg per day) for 5 consecutive days. In group 2, the taurine-supplemented diet was prescribed in reverse. At the end of the two periods, on days 5 and 10, bile was collected via a T-tube with an inflatable balloon and low-pressure motor suction. Analysis of conjugated bile acids was done by high-performance liquid chromatography. The results showed that a taurine-supplemented diet increased the concentration of taurocholic acid, glycocholic acid, taurochenodeoxycholic acid, glycochenodeoxycholic acid, and total bile acid from 0.5, 1.9, 0.3, 1.4, and 4.7 mg/mL (on day 5) to 1.1, 3.5, 1.0, 2.6, and 8.9 mg/mL, respectively, on day 10 in group 1. Similar findings were noted in group 2. These results indicate that a taurine-supplemented diet may enhance the conjugation and secretion of bile acid in hepatobiliary patients.
authors.affiliation: Department of Surgery, Provincial Tao-Yuan General Hospital, Taiwan, Republic of China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Wang
authors.forename: K Y
authors.initials: KY
authors.lastname: Liaw
mesh_terms: D000328:Adult; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002769:Cholelithiasis / Q000601:surgery*; D004032:Diet; D005260:Female; D005999:Glycochenodeoxycholic Acid / Q000378:metabolism; D006000:Glycocholic Acid / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D013654:Taurine / Q000008:administration & dosage / Q000627:therapeutic use*; D013655:Taurochenodeoxycholic Acid / Q000378:metabolism; D013656:Taurocholic Acid / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D013654:Taurine; D013655:Taurochenodeoxycholic Acid; D013656:Taurocholic Acid; D005999:Glycochenodeoxycholic Acid; D006000:Glycocholic Acid