title: Aluminium determination in the skin of patients with and without end-stage renal failure.
abstract: Aluminium (Al) concentration in the skin was determined by inductively coupled plasma optical emission spectrometry to look for a correlation between Al exposure and skin content in patients with end-stage renal failure. Skin Al concentrations were higher in dialyzed patients than in the nondialyzed group (1.02 +/- 0.30 vs. 0.26 +/- 0.10 micrograms/g; p less than 0.001). Moreover, in the dialyzed group, the patients treated for more than 100 months had a higher concentration of Al in the skin than the others (1.20 +/- 0.26 vs. 0.80 +/- 0.18 micrograms/g; p less than 0.05). Al skin content correlated better with the deferoxamine infusion test (DIT) than with Al blood plasma concentration. In conclusion, our data confirm that the DIT is a valuable tool for the evaluation of body Al content.
authors.affiliation: Service de Néphrologie, CHRU, Angers, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Subra
authors.forename: N
authors.initials: N
authors.lastname: Krari
authors.forename: P
authors.initials: P
authors.lastname: Tirot
authors.forename: Y
authors.initials: Y
authors.lastname: Mauras
authors.forename: G
authors.initials: G
authors.lastname: Balit
authors.forename: F C
authors.initials: FC
authors.lastname: Van-Weydevelt
authors.forename: P
authors.initials: P
authors.lastname: Allain
mesh_terms: D000328:Adult; D000368:Aged; D000535:Aluminum / Q000097:blood / Q000378:metabolism* / Q000506:poisoning; D003676:Deferoxamine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects; D012867:Skin / Q000378:metabolism*
chemical_list: D000535:Aluminum; D003676:Deferoxamine