Controversies regarding the natural history and treatment of syphilis in HIV disease.
Because of the immunologic dysfunction of HIV-infected patients, concomitant infection with T. pallidum requires that maximal doses of appropriate antibiotics be given, and the expected falls in nontreponemal antibody titer cannot be relied upon to certify a cure. Genital ulcer disease appears to increase the risk of acquiring HIV. Therefore, all HIV-infected persons and persons with syphilis should be tested for both syphilis and HIV.
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Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D013587:Syphilis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy