title: Intraocular pressure response to the replacement of pilocarpine or carbachol with echothiophate.
abstract: In 20 patients with open-angle glaucoma in aphakia or pseudophakia whose intraocular pressure had remained uncontrolled on their current medical therapy, the medication was changed from pilocarpine or carbachol to echothiophate iodide. In all, 12 patients (60%) showed a statistically significant improvement in pressure control, 7 (35%) showed no change, and 1 had higher pressure. One-third of the patients with improved intraocular-pressure control eventually required laser or incisional surgery after a mean of 23 months, whereas the remaining subjects were controlled for the duration of the follow-up, which averaged 26 months. Side effects encountered during echothiophate iodide treatment included ocular irritation, decreased vision, and one retinal detachment.
authors.affiliation: Duke University Eye Center, Durham, NC 27710.
authors.forename: R W
authors.initials: RW
authors.lastname: Reichert
authors.forename: M B
authors.initials: MB
authors.lastname: Shields
mesh_terms: D001035:Aphakia / Q000150:complications; D001036:Aphakia, Postcataract / Q000150:complications; D002217:Carbachol / Q000627:therapeutic use*; D004456:Echothiophate Iodide / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010862:Pilocarpine / Q000627:therapeutic use*; D012189:Retrospective Studies; D014786:Vision Disorders / Q000139:chemically induced
chemical_list: D010862:Pilocarpine; D002217:Carbachol; D004456:Echothiophate Iodide