title: [A comparative study of intra-arterial infusion chemotherapy and systemic chemotherapy in the treatment of locally advanced breast cancer].
abstract: A comparative randomized study of intra-arterial infusion chemotherapy (IA) and systemic chemotherapy (IV) was carried out on 41 patients with locally advanced breast cancer, and the following results were obtained. 1) The response rate of primary lesions to IA (63.2%) was better than that of IV (40.9%). 2) In the patients treated with IA, grade of leukopenia, as well as the percentage of gastro-intestinal disorders, was low. 3) More prolonged follow-up studies are required on the therapeutic effects on micrometastasis. The author confirmed that IA was an efficacious neoadjuvant therapy in terms of down staging of locally advanced breast cancer.
authors.affiliation: Dept. of Surgery, Osaka National Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Takatsuka
authors.forename: T
authors.initials: T
authors.lastname: Kawahara
authors.forename: E
authors.initials: E
authors.lastname: Yayoi
authors.forename: J
authors.initials: J
authors.lastname: Okamura
authors.forename: K
authors.initials: K
authors.lastname: Miyauchi
authors.forename: E
authors.initials: E
authors.lastname: Shiba
authors.forename: T
authors.initials: T
authors.lastname: Mori
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004334:Drug Administration Schedule; D015251:Epirubicin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008593:Menopause; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D015251:Epirubicin