title: [The clinical pharmacokinetics of kemantane].
abstract: The pharmacokinetics of a new Soviet-made immunostimulant kemantane, a derivative of adamantine, was studied by gas-liquid chromatography in patients with bronchial pathology. It was found that in the blood of the patients kemantane was not practically detected due to a pronounced effect of the "first pass" through the liver. Kemantane kinetics was evaluated by the kinetics of its major active metabolite. On the basis of the performed studies the scheme of using kemantane in the patients with decreased immunity was recommended.
authors.forename: S S
authors.initials: SS
authors.lastname: Boĭko
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: N A
authors.initials: NA
authors.lastname: Kisliak
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use; D000276:Adjuvants, Immunologic / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001991:Bronchitis / Q000188:drug therapy / Q000378:metabolism; D002849:Chromatography, Gas / Q000379:methods; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D013607:Tablets; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D013607:Tablets; C068220:kemantane; D000218:Adamantane
vernacular_title: Klinicheskaia farmakokinetika kemantana.