[Binding of cefuroxime to macromolecules from bronchitic sputum in patients with chronic bronchitis].
Cefuroxime binding to soluble bronchial macromolecules has been performed in vitro with preparations obtained from ten patients. Cefuroxime at various concentrations have been added to soluble macromolecules (10 g/l). Free cefuroxime has been obtained by equilibrium dialysis and measured by HPLC. Results show that cefuroxime binding is about 30% of total antibiotic.
Lhermitte
M
M
Unité des Protéines, INSERM (n.16), Lille.
Chiche
D
D
Houdret
N
N
Roussel
P
P
D001991:Bronchitis / Q000378:metabolism*; D002444:Cefuroxime / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D006801:Humans; D066298:In Vitro Techniques; D013183:Sputum / Q000187:drug effects* / Q000378:metabolism
D002444:Cefuroxime
Liaison de la céfuroxime aux macromolécules du mucus bronchique de malades atteints de bronchite chronique.