Interleukin-4 blocks parathyroid hormone-related protein-induced hypercalcemia in vivo.
Interleukin (IL)-4 inhibits bone resorption. In the present study, the effect of IL-4 on hypercalcemia in nude mice under two experimental conditions was assessed. IL-4 inhibited plasma calcium elevation induced by parathyroid hormone-related protein (PTHrP) infusion. In hypercalcemic nude mice bearing PTHrP-producing tumors, IL-4 lowered plasma calcium levels to almost the normal range. These results indicate that IL-4 blocks PTHrP-induced hypercalcemia in vivo.
Nagasaki
K
K
Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan.
Yamaguchi
K
K
Watanabe
K
K
Eto
S
S
Abe
K
K
D000818:Animals; D002118:Calcium / Q000097:blood; D002277:Carcinoma / Q000503:physiopathology; D002294:Carcinoma, Squamous Cell / Q000503:physiopathology; D002460:Cell Line; D006801:Humans; D006934:Hypercalcemia / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D015847:Interleukin-4 / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000503:physiopathology*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010281:Parathyroid Hormone / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D014183:Transplantation, Heterologous
D010281:Parathyroid Hormone; D010446:Peptide Fragments; D011994:Recombinant Proteins; D015847:Interleukin-4; D002118:Calcium