title: Principles and techniques of guided tissue regeneration.
abstract: Guided tissue regeneration is an accepted technique to promote new attachment in periodontal therapy. It is supported by sound basic research indicating that the definitive factor in the obtainment of regeneration is the source from which the cells repopulating the exposed root surface originate. These studies have indicated that cells proliferating from the periodontal ligament have the greatest potential for achieving new attachment. The use of barriers during periodontal surgery permits the possibility of periodontal ligament proliferation toward the exposed root at the same time that epithelial and gingival connective tissue proliferation is blocked. Studies in which Gore-Tex periodontal material has been used as a barrier have shown positive results in animal and clinical studies. Histologically, the formation of new cementum, bone, and periodontal ligament has been demonstrated. Clinically, beneficial results have been documented in the treatment of intrabony defects with three-wall, two- to three-wall, or funnel-shaped topography. Also, Class II furcations with or without a vertical component have been treated successfully by guided tissue regeneration.
authors.affiliation: Department of Periodontics, University of Texas Health Science Center, Houston.
authors.forename: R G
authors.initials: RG
authors.lastname: Caffesse
authors.forename: W
authors.initials: W
authors.lastname: Becker
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000502:physiology; D004846:Epithelial Attachment / Q000502:physiology; D006801:Humans; D008567:Membranes, Artificial; D010510:Periodontal Diseases / Q000601:surgery*; D010513:Periodontal Ligament / Q000502:physiology*; D012038:Regeneration / Q000502:physiology
chemical_list: D008567:Membranes, Artificial