Vascular eicosanoid production in experimental hypertensive rats with different mechanisms.
This study investigated the release of prostacyclin (PGI2) and thromboxane A2 (TXA2) from the aortic walls of various experimental hypertensive rats, e.g. spontaneously hypertensive rats (SHR), Dahl salt-sensitive (Dahl S) rats, deoxycorticosterone (DOCA)-salt hypertensive rats and renovascular (2-kidney, 1-clip (2K1C) and 1-kidney, 1-clip (1K1C] hypertensive rats. The PGI2 generation was increased significantly in these hypertensive models, irrespective of the hypertensive mechanisms, when they developed established hypertension. Dahl S rats, having an impaired PGI2 production on a low salt diet, restored PGI2 generating capacity to the control level of Dahl salt-resistant rats when they were fed a high salt diet and developed salt-induced hypertension. On the other hand, the TXA2 generation in the vascular walls was enhanced particularly in rat models for genetic hypertension, and this system was unaltered in the models for secondary hypertension, e.g. DOCA-salt and renovascular hypertension. Thus, it is suggested that the elevation of blood pressure is associated with an increase in vascular PGI2 production, and that the increased vascular TXA2 production is a characteristic feature of genetic hypertension.
Ishimitsu
T
T
2nd Department of Internal Medicine, University of Tokyo, Japan.
Uehara
Y
Y
Iwai
J
J
Sugimoto
T
T
Hirata
Y
Y
matsuoka
H
H
Sugimoto
T
T
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001794:Blood Pressure; D001808:Blood Vessels / Q000378:metabolism*; D004195:Disease Models, Animal; D015777:Eicosanoids / Q000096:biosynthesis* / Q000378:metabolism; D011464:Epoprostenol / Q000032:analysis / Q000378:metabolism*; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism*; D006978:Hypertension, Renovascular / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013928:Thromboxane A2 / Q000032:analysis / Q000378:metabolism*; D014316:Tritium
D015777:Eicosanoids; D014316:Tritium; D013928:Thromboxane A2; D011464:Epoprostenol