Chronopharmacology of the new uricosuric diuretic S-8666 in rats.
A new loop diuretic with uricosuric activity, 6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydro-2-benzofuran carboxylic acid (S-8666), was given orally at 12:00 a.m. or 12:00 p.m. in rats. The diuretic of S-8666 and the urinary excretions of the drug and its active metabolite S-8680 (N-demethyl S-8666) were greater at 12:00 a.m. than at 12:00 p.m. Thus, the present study indicates that the diuretic effects of S-8666 varies with its administration time. Time-dependent variations in the amount of urinary excretions of S-8666 and S-8680 might be involved in the mechanisms for this phenomenon.
Fujimura
A
A
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
Ohashi
K
K
Ebihara
A
A
D000818:Animals; D004232:Diuretics / Q000493:pharmacokinetics / Q000652:urine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D013449:Sulfonamides / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000652:urine; D013997:Time Factors; D014528:Uricosuric Agents / Q000493:pharmacokinetics / Q000652:urine
D004232:Diuretics; D013449:Sulfonamides; D014528:Uricosuric Agents; C052960:S 8666; D012964:Sodium