Longitudinal study on relapses of leprosy in Polynesian multibacillary patients on dapsone monotherapy between 1946 and 1970.
Between 1946 and 1970, 295 new leprosy patients were detected in French Polynesia, of whom 145 were multibacillary. Of these 145, put on dapsone monotherapy, 131 reached bacteriological negativity in a period of time ranging from 2 to 12 years (average 4.72 years) and were followed-up for a period of time ranging from 19 to 43 years (median follow-up period after bacteriological negativity; 18 years). Among the 131 patients, 36 relapses were detected, the first one 4 years after bacteriological negativity and the last one 26 years after. The crude relapse rate was 27.5%, the risk of relapse was 1.39 per 100 patient years and the cumulative relapse probability, calculated using the lifetable method, reached 0.38 +/- 11 by year 31 of the study. From these findings one may assume that, at least in French Polynesia, one-third to one-half of multibacillary patients put on dapsone monotherapy would relapse if still present 36 years after bacteriological negativity. Such results re-emphasize the need for leprosy patients to be treated with multidrug therapy as recommended by WHO.
Cartel
J L
JL
Institut Territorial de Recherches Medicales Louis Malarde, Papeete Tahiti-Polynesie Francaise.
Boutin
J P
JP
Spiegel
A
A
Plichart
R
R
Roux
J F
JF
D003622:Dapsone / Q000627:therapeutic use*; D006801:Humans; D007918:Leprosy / Q000188:drug therapy*; D008137:Longitudinal Studies; D011114:Polynesia; D011336:Probability; D012008:Recurrence; D012306:Risk
D003622:Dapsone