title: Elevated intravesical pressure causes arterial hypoperfusion in canine colocystoplasty: a fluorometric assessment.
abstract: Since 1988 there have been 15 reported cases of late, spontaneously ruptured intestinal cystoplasties at bowel sites remote from the anastomosis. Ischemic necrosis has been suggested as a possible etiology. We examined this hypothesis by quantifying the uptake of intravascular fluorescein in the augmented bowel of adult mongrel canines. There was a statistically significant decrease in fluorescein uptake at high intravesical pressures, which appeared to be most pronounced at the antimesenteric border. This laboratory study supports a recent clinical report of histological changes pathognomonic for chronic ischemia in the augmented bowel of patients with spontaneous rupture.
authors.affiliation: Division of Pediatric Urology, Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: K A
authors.initials: KA
authors.lastname: Essig
authors.forename: C A
authors.initials: CA
authors.lastname: Sheldon
authors.forename: M T
authors.initials: MT
authors.lastname: Brandt
authors.forename: J
authors.initials: J
authors.lastname: Wacksman
authors.forename: D G
authors.initials: DG
authors.lastname: Silverman
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001158:Arteries; D003106:Colon / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D003108:Colonic Diseases / Q000209:etiology; D004285:Dogs; D005260:Female; D005451:Fluorescein Angiography; D007511:Ischemia / Q000150:complications / Q000175:diagnosis / Q000209:etiology*; D009336:Necrosis; D011312:Pressure; D012422:Rupture, Spontaneous; D001743:Urinary Bladder / Q000098:blood supply* / Q000503:physiopathology / Q000601:surgery; D014547:Urinary Diversion