[Morphologic and morphometric aspects of the mammary gland of normal and oophorectomized rats treated with metoclopramide].
The authors performed an optical microscope morphologic and morphometric study of the mammary glands of rats treated and untreated with metoclopramide during estrous and after ovariectomy. They observed that in the group of normal rats treated with the drug the glands were well developed and contained secretion in the lumen of their ducts and alveoli. In the group of rats submitted to ovariectomy and treated with metoclopramide, however, the glands were atrophied and had the same aspect of glands during estrous. These findings are in agreement with the morphometric study, which showed a statistically significant increase of parenchyma in the group of normal treated rats as compared to the other groups and, further, a higher number of alveoli with secretion.
Sakumoto
S
S
Disciplina de Histologia, Escola Paulista de Medicina, São Paulo, Brasil.
Pardi
P C
PC
Simões
M de D
Mde D
Baracat
E C
EC
D000818:Animals; D004971:Estrus; D005260:Female; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000473:pathology*; D008787:Metoclopramide / Q000494:pharmacology*; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains
D008787:Metoclopramide
Aspectos morfológicos e morfométricos da glândula mamária de ratas normais e ooforectomizadas tratadas com metoclopramida.