title: Angioedema: manifestations and management.
abstract: Angioedema is characterized by localized swelling of sudden onset affecting the skin and/or mucous membranes. It can be classified into hereditary and acquired forms. Hereditary angioedema is a rare disease inherited as an autosomal dominant trait and caused by a deficiency of C1-esterase inhibitor. Acute attacks are life threatening and cannot be managed by antihistamines, corticosteroids, or adrenergic drugs. Prophylactic therapy is possible with danazol or stanozolol. Acquired angioedema includes nonhereditary C1-esterase inhibitor deficiency; idiopathic, allergic, and drug-induced forms; angioedema associated with lupus erythematosus and hypereosinophilia; and angioedema caused by physical stimuli. Treatment of these forms of angioedema depends on identifying and avoiding the cause, induction of tolerance, or symptomatic treatment with systemic antihistamines.
authors.affiliation: Institute of Dermatology, St. Thomas's Hospital, London, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Greaves
authors.forename: F
authors.initials: F
authors.lastname: Lawlor
mesh_terms: D000799:Angioedema / Q000188:drug therapy / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D006801:Humans