Effects of antiestrogens on ovarian aldo-keto reductase in relation to ovulation in rats.
The pharmacological effects of antiestrogens on ovarian aldo-keto reductase and ovulation were investigated in rats. The activities of reduction of 13,14-dihydro-15-keto-PGF2 alpha, 4-benzoylpyridine and menadione in ovarian cytosol were significantly decreased by antiestrogen treatments, and the ovulation was completely inhibited. However, administration of luteinizing hormone-releasing hormone at 3:00 p.m. on the day of proestrus restored both enzyme activities and ovulation, which were inhibited by antiestrogens, to control levels. These results indicate that nonsteroidal antiestrogen inhibits the luteinizing hormone surge on the day of proestrus in 4-day cycling rats and that ovarian aldo-keto reductase may be closely involved in the ovulatory process in rats.
Inaba
N
N
Department of Pharmacology and Toxicology, Tokyo College of Pharmacy, Japan.
Inazu
N
N
Kogo
H
H
Satoh
T
T
D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000449:Aldehyde Reductase; D000074408:Aldo-Keto Reductases; D000818:Animals; D004965:Estrogen Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D010053:Ovary / Q000201:enzymology* / Q000378:metabolism; D010060:Ovulation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000378:metabolism
D004965:Estrogen Antagonists; D000429:Alcohol Oxidoreductases; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase