title: Noninvasive temperature imaging using diffusion MRI.
abstract: Efficacy and safety considerations for cancer therapy with hyperthermia require accurate temperature measurements throughout the heated volume. We report the use of molecular diffusion, whose temperature dependence is well known. A dedicated hyperthermia applicator was built, combining a MRI gradient coil and a rf coil. Diffusion and derived temperature images were obtained with a 1 x 2 mm pixel size on a polyacrylamide gel phantom using a clinical 1.5-T whole body MRI system. Temperatures determined from these images using 1 cm2 regions of interest were found to be within 0.2 degrees C of those recorded from the thermocouples and fiber-optic probes placed inside the gel.
authors.affiliation: Biomedical Engineering and Instrumentation Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: J
authors.initials: J
authors.lastname: Delannoy
authors.forename: C N
authors.initials: CN
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Turner
authors.forename: R L
authors.initials: RL
authors.lastname: Levin
authors.forename: D
authors.initials: D
authors.lastname: Le Bihan
mesh_terms: D001831:Body Temperature; D004058:Diffusion; D004867:Equipment Design; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D008954:Models, Biological; D008961:Models, Structural; D013821:Thermometers; D014783:Viscosity