[Study of biological equilibrium in the body in viral infection of different degree of severity (on the model of influenza)].
The authors made a comparative analysis of the contribution to the outcome of the disease by realization of information of viral genome and host responses in the time-course of simulated lethal and nonlethal mice influenza. They studied the effect of ionol, pathogenetic antioxidant, prevention and depicted absolutely new features of the diseases severity and outlined possible points of effective drug application. The suggested scheme of the time-course measurement of viral involvement of the host body and the formation of its responses could be recommended in the study of mechanisms of the viral infection development and the activity of antiviral agents.
Poliak
R Ia
RIa
Voĭtsekhovskiĭ
B L
BL
Dubrovina
T Ia
TIa
Dukhin
A I
AI
Ivanova
I A
IA
Koltyreva
T V
TV
Kramskaia
T A
TA
Leont'eva
G F
GF
Meringova
L F
LF
Chetverikova
L K
LK
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology*; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage; D004195:Disease Models, Animal; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D012720:Severity of Illness Index
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D002084:Butylated Hydroxytoluene
Biologicheskoe ravnovesie v organizme pri virusnoĭ infektsii raznoĭ tiazhesti (na modeli grippa).