Effect of inhaled 15-(s)-hydroxyeicosatetraenoic acid on tracheobronchial clearance in normal human airways.
15-(s)-Hydroxyeicosatetraenoic acid (15-HETE) is the predominant metabolite of arachidonic acid in normal and asthmatic human airways and a potent mucus secretagogue in canine and human airways. A study was carried out on the effect of inhaled 15-HETE on tracheobronchial clearance, measured for six hours by a radioaerosol technique, in 10 normal subjects. Subjects inhaled 80 nmol 15-HETE or the diluent (sodium phosphate buffer) on two occasions at least two weeks apart in a double blind and randomised fashion (20 minutes after radioaerosol inhalation. Tracheobronchial clearance after inhaled 15-HETE was almost identical to that after placebo for all measurements up to six hours. It is concluded that 15-HETE has no effect on tracheobronchial clearance in normal human airways and is unlikely to account for the impaired mucociliary clearance seen in asthma.
Lai
C K
CK
Immunopharmacology Group, Medicine I, Southampton General Hospital.
Polosa
R
R
Pavia
D
D
Hasani
A
A
Agnew
J E
JE
Clarke
S W
SW
Holgate
S T
ST
D000280:Administration, Inhalation; D000328:Adult; D001980:Bronchi / Q000187:drug effects*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects*; D014797:Vital Capacity / Q000187:drug effects
D006893:Hydroxyeicosatetraenoic Acids