Pyridoxine neuropathy. A four-year electrophysiological and clinical follow-up of a severe case.
In a 54-year-old male a severe sensory neuropathy was observed during treatment for pulmonary tuberculosis with isoniazid (400 mg/day) and pyridoxine (600 mg/day). Eight months after withdrawal from isoniazid the sensory symptomatology was still progressing, although muscle strength was never reduced. A sural nerve biopsy revealed marked loss of large myelinated fibres. Only when pyridoxine treatment was interrupted did a slow improvement begin. A clinical and electrophysiologic follow-up showed a very slow and still incomplete recovery after four years. The possibility of an unusual individual susceptibility to toxic effects of pyridoxine is considered.
Santoro
L
L
Department of Clinical Neurophysiology and Neurological Clinic, 2nd School of Medicine, University of Naples, Italy.
Ragno
M
M
Nucciotti
R
R
Barbieri
F
F
Caruso
G
G
D004594:Electrophysiology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D011736:Pyridoxine / Q000009:adverse effects*; D013497:Sural Nerve / Q000473:pathology
D011736:Pyridoxine