[A behavioral and biochemical analysis of the therapeutic effect of sodium oxybutyrate in alcoholic encephalopathy in progeny].
The alcoholization of pregnant female rats (5 g/kg) results in a decrease of endogenous ethanol level in their offspring and distant disturbances of the conditioned reflex activities of the young rats deteriorating the formation and preservation of the skill with an emotional positive reinforcement. Sodium gamma-gydroxybutyrate administered in a dose of 50 mg/kg from the 8th to the 20th day of life prevents the above-mentioned disturbances of learning and memory, restores the level of endogenous ethanol, corrects the parameters of lipid and mediator metabolism in the brain and blood changed by prenatal alcoholization.
Trofimov
S S
SS
Ostrovskaia
R U
RU
Smol'nikova
N M
NM
Nemova
E P
EP
Bobrova
O V
OV
Koltovaia
N A
NA
Ushakov
A N
AN
Tsirenina
M L
ML
D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001679:Biogenic Amines / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001927:Brain Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000633:toxicity; D005260:Female; D007858:Learning / Q000187:drug effects; D050356:Lipid Metabolism; D008568:Memory / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012978:Sodium Oxybate / Q000627:therapeutic use*
D001679:Biogenic Amines; D000431:Ethanol; D012978:Sodium Oxybate
Povedencheskiĭ i biokhimicheskiĭ analiz terapevticheskogo éffekta natriia oksibutirata pri alkogol'noĭ éntsefalopatii u potomstva.