title: Plasma factor VII is activated by postprandial triglyceridaemia, irrespective of dietary fat composition.
abstract: Nine adults took two 7-day diets of standardised energy and total fat content, but with a dietary polyunsaturated/saturated fat ratio of less than 0.3 and greater than 3.0 respectively, while adhering to their daily routine. Blood was drawn on 6 occasions between 09.00 and 22.45 h on the final day of each dietary period for factor VII activity (VIIc), factor VII antigen (VIIag) and lipoprotein lipid concentrations. Diurnal variation was described for each variable in terms of its deviation from the individual's daily mean value at each time point across the day. Plasma triglyceride remained low until after the midday meal, whereafter a marked rise was sustained into the later evening. Plasma VIIc declined until early afternoon, but showed a marked rise in the late afternoon. Plasma VIIag showed no significant diurnal variation. Changes in plasma triglyceride concentration during the day were related positively to changes in VIIc about 160 min later, but not to VIIc at other time points. This effect of postprandial triglyceridaemia on VIIc persisted after allowance for the effect of VIIag on VIIc. Dietary fat composition did not influence VIIc or VIIag. The results suggested an acute but evanescent effect of triglyceride-rich lipoproteins on the reactivity of factor VII, irrespective of their lipid core composition.
authors.affiliation: MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, U.K.
authors.forename: G J
authors.initials: GJ
authors.lastname: Miller
authors.forename: J C
authors.initials: JC
authors.lastname: Martin
authors.forename: K A
authors.initials: KA
authors.lastname: Mitropoulos
authors.forename: B E
authors.initials: BE
authors.lastname: Reeves
authors.forename: R L
authors.initials: RL
authors.lastname: Thompson
authors.forename: T W
authors.initials: TW
authors.lastname: Meade
authors.forename: J A
authors.initials: JA
authors.lastname: Cooper
authors.forename: J K
authors.initials: JK
authors.lastname: Cruickshank
mesh_terms: D000941:Antigens / Q000032:analysis; D002940:Circadian Rhythm; D004041:Dietary Fats / Q000008:administration & dosage*; D005167:Factor VII / Q000032:analysis / Q000276:immunology; D015942:Factor VIIa / Q000378:metabolism*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D014280:Triglycerides / Q000097:blood*
chemical_list: D000941:Antigens; D004041:Dietary Fats; D008074:Lipoproteins; D014280:Triglycerides; C042580:factor VII clotting antigen; C031500:factor VII related antigen; D005167:Factor VII; D015942:Factor VIIa