Comparison of the chromatographic characteristics of metabolites of tacrine hydrochloride in human serum and urine with those of in vitro metabolic products from hepatic microsomes.
There may be as many as five metabolites of THA in man, four corresponding to products in the rat. The study provides some evidence that one of major metabolites is 1-hydroxy-THA but lends no support to the putative oxidative deamination pathway.
Truman
C A
CA
Department of Medicine, Bristol Royal Infirmary, U.K.
Ford
J M
JM
Roberts
C J
CJ
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013619:Tacrine / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000652:urine
D002800:Cholinesterase Inhibitors; D013619:Tacrine; C056424:velnacrine