[A new approach to the search for antineoplastic compounds].
The necessity of using microbial test systems with regular reproduction of associated impairments in cell differentiation and division in screening of antitumor compounds is substantiated. Conditions for induction of such impairments during secondary growth in prokaryotic and eukaryotic mycelial microorganisms were developed. The fungal culture, Fusarium bulbigenum var. blasticola, the growth of whose secondary colonies was selectively inhibited by representatives of various classes of antitumor agents such as alkylating agents, antimetabolites, antibiotics, plant preparations, etc. was isolated.
Nikitina
E T
ET
Aĭtkhozhina
N A
NA
Esenova
Sh Sh
ShSh
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D005057:Eukaryotic Cells / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects / Q000302:isolation & purification; D011387:Prokaryotic Cells / Q000187:drug effects
D000903:Antibiotics, Antineoplastic
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