title: [Intranasal premedication of young children using midazolam (Dormicum). Clinical experience].
abstract: The effect of 0.2 mg/kg body weight intranasal midazolam as a premedicant was investigated in 38 children (age 2-13 years, body weight 10-28 kg) prior to ENT surgery. Intranasal midazolam showed a rapid onset of action with 79% and 95% of the children being sufficiently premedicated at 5 minutes (p less than 0.05) and 10 minutes (p less than 0.01) after application, respectively, as opposed to 45% prior to this. This finding is in keeping with pharmacokinetics showing a tmax of intranasal midazolam of 11 minutes and a bioavailability of 51% in children (10). With the advent of a higher concentrated solution of midazolam intranasal application is also conceivable as a premedication in adults.
authors.affiliation: Anästhesieabteilung des Städtischen Krankenhauses Stade.
authors.forename: R
authors.initials: R
authors.lastname: Bünz
authors.forename: M
authors.initials: M
authors.lastname: Gossler
mesh_terms: D000281:Administration, Intranasal; D000556:Ambulatory Surgical Procedures; D000768:Anesthesia, General; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008874:Midazolam / Q000008:administration & dosage*; D010038:Otorhinolaryngologic Diseases / Q000601:surgery; D011229:Preanesthetic Medication
chemical_list: D008874:Midazolam
vernacular_title: Die intranasale Prämedikation bei Kleinkindern mit Midazolam (Dormicum). Klinischer Erfahrungsbericht.