title: Existence of host-related DNA sequences in the schistosome genome.
abstract: DNA sequences homologous to the mouse intracisternal A particle and endogenous type C retrovirus were detected in the DNAs of Schistosoma japonicum adults and S. mansoni eggs. Furthermore, other kinds of repetitive sequences in the host genome such as mouse type 1 Alu sequence (B1), mouse type 2 Alu sequence (B2) and mo-2 sequence, a mouse mini-satellite, were also detected in the DNAs from adults and eggs of S. japonicum and eggs of S. mansoni. Almost all of the sequences described above were absent in the DNAs of S. mansoni adults. The DNA fingerprints of schistosomes, using the mo-2 sequence, were indistinguishable from each other and resembled those of their murine hosts. Moreover, the mo-2 sequence was hypermethylated in the DNAs of schistosomes and its amount was variable in them. These facts indicate that host-related sequences are actually present in schistosomes and that the mo-2 repetitive sequence exists probably in extra-chromosome.
authors.affiliation: Institute of Basic Medical Sciences, University of Tsukuba, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iwamura
authors.forename: Y
authors.initials: Y
authors.lastname: Irie
authors.forename: R
authors.initials: R
authors.lastname: Kominami
authors.forename: T
authors.initials: T
authors.lastname: Nara
authors.forename: K
authors.initials: K
authors.lastname: Yasuraoka
mesh_terms: D000818:Animals; D004247:DNA / Q000032:analysis*; D016172:DNA Fingerprinting; D051379:Mice; D008813:Mice, Inbred ICR; D009693:Nucleic Acid Hybridization; D012091:Repetitive Sequences, Nucleic Acid; D012549:Schistosoma japonicum / Q000235:genetics*; D012550:Schistosoma mansoni / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004247:DNA