title: Clonazepam in acute mania: a double blind trial.
abstract: In a double-blind trial involving acutely manic patients, clonazepam was compared to placebo, both groups receiving chlorpromazine as needed. The group receiving clonazepam showed significantly more improvement in their manic but not their psychotic symptoms compared to the placebo group. This effect was not primarily related to the sedative effects of clonazepam. Clonazepam tended to reduce the need for phenothiazine medication. Side effects related to sedation were more common to the clonazepam group. These findings are the first to indicate that clonazepam may have a specific antimanic effect over and above that of phenothiazines alone.
authors.affiliation: Department of Psychiatry, Memorial Hospital, Hastings, New Zealand.
authors.forename: R
authors.initials: R
authors.lastname: Edwards
authors.forename: U
authors.initials: U
authors.lastname: Stephenson
authors.forename: T
authors.initials: T
authors.lastname: Flewett
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D002746:Chlorpromazine / Q000009:adverse effects / Q000627:therapeutic use; D002998:Clonazepam / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
chemical_list: D002998:Clonazepam; D002746:Chlorpromazine