title: [An experimental study on portal infusion of 5-fluorouracil].
abstract: We conducted these experiments to investigate the differences between continuous portal and one shot portal infusion of 5-fluorouracil (5-FU) using male Donryu rats. Continuous portal infusion of 5-FU (20 mg/kg/day x 5 days) revealed no remarkable side effects on the rats with significant decrease in the number of liver metastases generated by intraportal inoculation of ascites hepatoma AH60C. Consecutive 5-day administration of 5-FU (20 mg/kg x 5) by one shot method via spleen resulted in no metastases but caused death in 75% of rats because of severe leukopenia and dehydration. The rats receiving one shot infusion of 5-FU (33.3 mg/kg x 3, day 1, 3, 5) via spleen showed a significant decrease in the number of metastases without lethal side effects. Continuous portal infusion of 5-FU would be a safe and effective therapy to prevent liver metastases, whereas one shot portal infusion of 5-FU may give rise to severe side effects while preventing liver metastases.
authors.affiliation: Second Dept. of Surgery, Tokyo Medical and Dental University, School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Ishida
authors.forename: T
authors.initials: T
authors.lastname: Iwama
authors.forename: Y
authors.initials: Y
authors.lastname: Nishioka
authors.forename: S
authors.initials: S
authors.lastname: Endo
authors.forename: Y
authors.initials: Y
authors.lastname: Okubo
authors.forename: M
authors.initials: M
authors.lastname: Imajo
authors.forename: M
authors.initials: M
authors.lastname: Otomo
authors.forename: Y
authors.initials: Y
authors.lastname: Mishima
mesh_terms: D000818:Animals; D005472:Fluorouracil / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control / Q000556:secondary; D008297:Male; D011169:Portal Vein; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005472:Fluorouracil