Penile detumescence: characterization of three phases.
In 22 dogs in which erection was induced by cavernous nerve stimulation, we analyzed the intracavernous pressure changes during detumescence without and with acute clamping of the aorta or electrostimulation of the lumbar sympathetic chains. Additionally, the degree of venous outflow obstruction was assessed by saline perfusion of the cavernous body during aortic occlusion. Detumescence had three distinct phases: an initial phase exhibiting a small pressure increase; a second phase showing a slow pressure decrease; and a third phase in which a fast decrease occurred. The first phase was abolished by aortic clamping, whereas the other phases were not significantly affected. Sympathetic stimulation abolished or prevented the second phase. Perfusion of the cavernous body during the second phase resulted in a pressure rise to off-scale values; however, when initiated during the terminal phase or in the nonstimulated penis, the pressure increase was slight. Our study indicates that the arterial flow rate influences the duration of the first phase of detumescence and that venous drainage is completely restored in the third phase. Furthermore, sympathetic stimulation causes an almost immediate full restoration of venous drainage, as cavernous perfusion initiated with an intracavernous pressure about twice as high as without sympathetic stimulation failed to increase pressure to off-scale values.
Bosch
R J
RJ
Department of Urology, University of California, San Francisco.
Benard
F
F
Aboseif
S R
SR
Stief
C G
CG
Lue
T F
TF
Tanagho
E A
EA
D000818:Animals; D001011:Aorta / Q000502:physiology; D001794:Blood Pressure; D003250:Constriction; D004285:Dogs; D004558:Electric Stimulation; D008297:Male; D010410:Penile Erection / Q000502:physiology*; D010413:Penis / Q000098:blood supply / Q000294:innervation / Q000502:physiology; D012039:Regional Blood Flow; D013564:Sympathetic Nervous System / Q000502:physiology