Calcium binding induces conformational changes in muscle regulatory proteins.
Calcium binding to proteins containing the 'EF-hand' structural motif regulates a variety of biochemical processes including muscle contraction. Techniques such as protein crystallography, site-directed mutagenesis and domain transplantation experiments are being used to unravel the conformational changes induced by calcium binding.
da Silva
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AC
Departmento de Bioquimica, Universidade de Sao Paulo CP, Brazil.
Reinach
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FC
D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D008670:Metals / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D009119:Muscle Contraction; D009124:Muscle Proteins / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation
D002135:Calcium-Binding Proteins; D008670:Metals; D009124:Muscle Proteins; D002118:Calcium