Characterization of tumor-infiltrating mononuclear cells in renal cell cancer: quantitative analysis by immunoperoxidase staining.
In order to determine whether tumor-infiltrating mononuclear cells (TIM) of renal cell cancer (RCC) is suitable for adoptive immunotherapy, their number and characteristics were examined immunohistologically. TIM consisted of T cells and a smaller number of macrophages. Among T cells, CD8-positive cells were the dominant population which was reported to be more potent for the lysis of tumor cells. The number of T cells was variable: in 5 tumors no T cells were observed and in an other 5 the number of T cells were less than 2 x 10(6) cells/cm3. These results suggest that the TIM of RCC might be favorable for adoptive immunotherapy but TIM could not be available in some cases because of their small number.
Tomita
Y
Y
Department of Immunology, Niigata University, School of Medicine, Japan.
Nishiyama
T
T
Fujiwara
M
M
Sato
S
S
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D016219:Immunotherapy, Adoptive; D007680:Kidney Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D000911:Antibodies, Monoclonal; D015703:Antigens, CD