Influence of sulbactam plus ampicillin on theophylline clearance.
The effect of sulbactam/ampicillin (500 mg/1000 mg) every 12 hours taken for seven days on the steady-state pharmacokinetics of theophylline was studied among 12 patients suffering from chronic obstructive pulmonary disease. Theophylline concentrations were measured serially for 12 h by the method of polarized immunofluorescence (Abbott TDx system). No influence of sulbactam/ampicillin was detectable on the theophylline half-life, clearance or volume of distribution. It was concluded that both drugs could be administered concomitantly without any dosage adjustment of theophylline.
Cazzola
M
M
36th Division of Pneumology and Respiratory Allergy, A. Cardarelli Hospital, Naples, Italy.
Santangelo
G
G
Guidetti
E
E
Mattina
R
R
Caputi
M
M
Girbino
G
G
D000328:Adult; D000667:Ampicillin / Q000494:pharmacology*; D004347:Drug Interactions; D016231:Fluorescence Polarization Immunoassay; D006207:Half-Life; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000378:metabolism; D013407:Sulbactam / Q000494:pharmacology*; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*
D000667:Ampicillin; D013806:Theophylline; D013407:Sulbactam