title: Angiotensin II as a potential method of targeting cytotoxic-loaded microspheres in patients with colorectal liver metastases.
abstract: Regional chemotherapy is commonly used to treat patients with colorectal liver metastases. However, improvement in survival has still not been demonstrated. Cytotoxic loaded albumin microspheres for arterial administration have been described as a means of improving the the therapeutic index, but their distribution depends upon the prevailing pattern of arterial blood-flow at the time of injection. In this study, the ability of the vasoactive drug angiotensin II to target arterially injected microspheres to colorectal liver metastases is assessed in nine patients using scintigraphic planar and tomographic imaging. The median tumour: normal ratio in nine patients with colorectal liver metastases was 3.4:1 before the administration of angiotensin II. The corresponding ratio after administration of angiotensin II was 7.3:1. The median improvement factor was 1.8 (P less than 0.05). The data suggest that worthwhile tumour targeting can be achieved with angiotensin II in patients with colorectal liver metastases.
authors.affiliation: University Department of Surgery, Royal Infirmary, Glasgow, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Goldberg
authors.forename: J A
authors.initials: JA
authors.lastname: Thomson
authors.forename: M S
authors.initials: MS
authors.lastname: Bradnam
authors.forename: J
authors.initials: J
authors.lastname: Fenner
authors.forename: R G
authors.initials: RG
authors.lastname: Bessent
authors.forename: J H
authors.initials: JH
authors.lastname: McKillop
authors.forename: D J
authors.initials: DJ
authors.lastname: Kerr
authors.forename: C S
authors.initials: CS
authors.lastname: McArdle
mesh_terms: D000804:Angiotensin II / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D004337:Drug Carriers; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D008863:Microspheres; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D013668:Technetium Tc 99m Aggregated Albumin; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D004337:Drug Carriers; D013668:Technetium Tc 99m Aggregated Albumin; D000804:Angiotensin II