[Features of the interaction of antitumor mitoxantrone compounds with sarcoma 45 tumor DNA].
The interaction of antitumoral drug mitoxantrone with DNA of the tumor sarcoma 45 and healthy animals liver has been investigated according to the character of changes on the absorption spectra at binding at 30 degrees C and 0.11 M NaCl. The investigation shows that the interaction of mitoxantrone with DNA of sarcoma 45 differs from that with DNA of healthy animals liver. The calculations show that the saturation stoichiometry by both DNA is one mitoxantrone molecule per 2.5 base pairs with the binding constant k = 4 x 10(5) M-1 (for binding mitoxantrone with liver DNA) and k = 3 x 10(6) M-1 (with tumor DNA). Possible reason of such a difference is discussed on the basis of structural peculiarities of tumor DNA.
Babaian
Iu S
IuS
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008942:Mitoxantrone / Q000378:metabolism*; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism*; D013057:Spectrum Analysis
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D004247:DNA; D008942:Mitoxantrone
Osobennosti vzaimodeĭstviia protivoopukholevogo soedineniia mitoksantrona s DNK opukholi sarkomy 45.