title: Effect of supplementation with water-soluble vitamins on erythrocyte alanine aminotransferase activity of healthy adolescents.
abstract: The erythrocyte alanine aminotransferase (E-ALAT) activity with and without in vitro stimulation by pyridoxal phosphate of 60 healthy adolescents was measured before and after 6 weeks of supplementation with different water-soluble vitamins. The subjects who were divided into six groups received placebo (lactose tablets), pyridoxine, pyridoxine + ascorbic acid, pyridoxine + iron, pyridoxine + riboflavin and multivitamin supplements, respectively. Presupplementation E-ALAT activity increased significantly (p less than 0.05) for all supplemented subjects after 6 weeks. Deficient subjects (E-ALAT) index less than 1.16) however failed to respond to a combination of pyridoxine + ascorbic acid or multivitamins. It is suggested that pyridoxine in multivitamin preparations must exceed 1 mg to produce any useful improvement in vitamin B6 status of adolescents on suboptimal vitamin B6 intakes.
authors.affiliation: Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: O
authors.initials: O
authors.lastname: Korede
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood*; D001205:Ascorbic Acid / Q000008:administration & dosage; D002648:Child; D004032:Diet; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D011736:Pyridoxine / Q000008:administration & dosage; D012995:Solubility; D014815:Vitamins / Q000008:administration & dosage*; D014867:Water
chemical_list: D014815:Vitamins; D014867:Water; D000410:Alanine Transaminase; D011736:Pyridoxine; D001205:Ascorbic Acid