title: [Therapeutic possibilities of inhalation of rifampicin with dimexide in phthisiopulmonology].
abstract: The efficacy of treatment with rifampicin-dimexide++ aerosols of 184 pulmonary tuberculosis patients and 18 chronic obstructive bronchitis patients was studied. The character of the residual changes following the main chemotherapeutic course was studied in 98 patients. Dimexide++ was proved to be a good rifampicin solvent and synergist enhancing its bacteriostatic action. Rifampicin used in a dose of 150-300 mg in 3-4 ml of dimexide++ in aerosols for 1-2 months promotes bacillary excretion cessation and healing of destruction cavities and allows for a reduction of its toxic action on liver parenchyma. Rifampicin--dimexide++ aerosols contribute to more complete tuberculosis cure and reduce the residual pulmonary and bronchial changes. Rifampicin with dimexide++ can be successfully used for treating chronic bronchitis both as an independent disease and concurrent disease in pulmonary tuberculosis.
authors.forename: I N
authors.initials: IN
authors.lastname: Gorbach
authors.forename: V S
authors.initials: VS
authors.lastname: Samtsov
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000368:Aged; D001991:Bronchitis / Q000188:drug therapy*; D002908:Chronic Disease; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage*; D004338:Drug Combinations; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D012293:Rifampin; D004121:Dimethyl Sulfoxide
vernacular_title: Terapevticheskie vozmozhnosti ingaliatsiĭ rifampitsina s dimeksidom vo ftiziopul'monologii.