title: [The clinico-instrumental evaluation of the efficacy of picotamide in treating chronic obstructive arteriopathies of the lower extremities].
abstract: In 25 patients (19 males and 6 females) suffering from chronic arteriopathy of lower extremities at Fontaine stage II, the clinical efficacy of picotamide was investigated in double blind, cross over placebo-controlled study. Patients were assigned randomly to the treatment with placebo or picotamide (900 mg/die) for three months and, after 15 days of wash-out, to the treatment with picotamide or placebo for the same period. Painfree walking distance and ankle/arm systolic pressure ratio improved significantly only during picotamide treatment. Laboratory monitoring revealed a significant decrease in platelet aggregation and an increase of fibrinogen degradation products only during picotamide treatment. Three patients during picotamide treatment referred transient gastrointestinal discomfort (nausea, vomiting and diarrhoea); however in no case the treatment was suspended because of the appearance of these symptoms. These results indicate that picotamide is an effective drug in the management of chronic arteriopathy of lower extremities.
authors.affiliation: II Facoltà di Medicina e Chirurgia, Cattedra di Geriatria, Università degli Studi di Napoli.
authors.forename: V
authors.initials: V
authors.lastname: Canonico
authors.forename: V
authors.initials: V
authors.lastname: Ammaturo
authors.forename: P
authors.initials: P
authors.lastname: Guarini
authors.forename: C
authors.initials: C
authors.lastname: Tedeschi
authors.forename: G
authors.initials: G
authors.lastname: Nunziata
authors.forename: A
authors.initials: A
authors.lastname: Nappi
authors.forename: L
authors.initials: L
authors.lastname: Forgione
authors.forename: F
authors.initials: F
authors.lastname: Rengo
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy / Q000503:physiopathology; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010795:Phthalic Acids / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*
chemical_list: D010795:Phthalic Acids; D010975:Platelet Aggregation Inhibitors; C011581:picotamide
vernacular_title: Valutazione clinico-strumentale della efficacia della picotamide nel trattamento delle arteriopatie croniche ostruttive degli arti inferiori.