Influence of vegetable oil vehicles on bone-marrow proliferation in the mouse micronucleus test.
The detection of genotoxins in the mouse bone-marrow micronucleus (MN) test is sensitive to factors which may inhibit bone-marrow proliferation. We have shown that three commercially available cooking oils (olive, peanut and sunflower seed oils), commonly used as vehicles in toxicological tests, were able to induce a cytotoxic effect in mouse bone marrow. The effects observed were reversible and the magnitude of the responses varied with the oil administered. The results suggest a need to examine vehicle effects when conducting the MN test.
Simula
A P
AP
Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia.
Priestly
B G
BG
D000818:Animals; D001854:Bone Marrow Cells; D051379:Mice; D015162:Micronucleus Tests; D014677:Pharmaceutical Vehicles; D010938:Plant Oils / Q000633:toxicity*
D014677:Pharmaceutical Vehicles; D010938:Plant Oils