title: Magnetocardiographic functional localization using a current dipole in a realistic torso.
abstract: We describe a fast and numerically effective biomagnetic inverse solution using a moving dipole in a realistic homogeneous torso. We applied the localization model and high-resolution magnetocardiographic mapping to localize noninvasively the ventricular preexcitation site in ten patients suffering from Wolff-Parkinson-White syndrome. In all cases, the computed localization results were compared to the results obtained by invasive catheter technique. Using a standard-size torso model in all cases, the average 3-D distance between the computed noninvasive locations and the invasively obtained results was 2.8 +/- 1.4 cm. When the torso was rescaled to better match the true shape of the subject in five cases, the 3-D average was improved to 2.2 +/- 1.0 cm. This accuracy is very satisfactory, suggesting that the method would be clinically useful.
authors.affiliation: Department of Technical Physics, Helsinki University of Technology, Espoo, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Nenonen
authors.forename: C J
authors.initials: CJ
authors.lastname: Purcell
authors.forename: B M
authors.initials: BM
authors.lastname: Horacek
authors.forename: G
authors.initials: G
authors.lastname: Stroink
authors.forename: T
authors.initials: T
authors.lastname: Katila
mesh_terms: D000328:Adult; D004562:Electrocardiography; D005260:Female; D006334:Heart Function Tests / Q000379:methods*; D006801:Humans; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D014927:Wolff-Parkinson-White Syndrome / Q000175:diagnosis*