Chelation in metal intoxication. XXXIV. Mixed ligand chelation in lead poisoning.
The effectiveness of alpha-mercapto-beta-(2-furyl)acrylic acid (MFA) and N-benzyl-N-dithiocarboxy-D-glucamine (NaB), used in combination, in the mobilization and excretion of lead was investigated in rats. Male Wistar rats received 10 mg Pb/kg as lead acetate intragastrically daily for 6 weeks. The lead-exposed rats were treated with either MFA or NaB or both 200 mumol/kg i.p., each, daily for 3 days. Both chelating agents provoked significant urinary and faecal excretion and lowered the soft-organ lead burden. However, combined therapy did not elicit any additive or synergistic response.
Kachru
D N
DN
Industrial Toxicology Research Centre, Lucknow, India.
Singh
S
S
Tandon
S K
SK
D000179:Acrylates / Q000008:administration & dosage*; D000818:Animals; D000931:Antidotes / Q000008:administration & dosage*; D002614:Chelating Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D007855:Lead Poisoning / Q000188:drug therapy*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013012:Sorbitol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013859:Thiocarbamates / Q000008:administration & dosage*
D000179:Acrylates; D000931:Antidotes; D002614:Chelating Agents; D013859:Thiocarbamates; D013012:Sorbitol; C015341:2-mercapto-3-furan-2-ylpropenoic acid; C048763:N-benzylglucamine dithiocarbamate