Subcellular fractions of rat organs contain nitroreductases which reduce N-nitrodimethylamine to N-nitrosodimethylamine.
The nasal carcinogen N-nitrodimethylamine was reduced to its N-nitroso analogue N-nitrosodimethylamine in vivo. Liver-soluble fraction and brain mitochondria contained enzymes capable of reducing this compound. The activity was only partly inhibited by oxygen; NADPH and NADH served as cosubstrates. N-Nitromethylamine is also carcinogenic and was reduced by liver cytoplasm to a protein binding species (methyldiazohydroxide?).
Frei
E
E
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
Hassel
M
M
Spiegelhalder
B
B
Wiessler
M
M
D000818:Animals; D001711:Biotransformation; D004123:Dimethylamines / Q000378:metabolism*; D004128:Dimethylnitrosamine / Q000378:metabolism*; D009601:Nitroreductases / Q000032:analysis*; D010084:Oxidation-Reduction; D051381:Rats; D013347:Subcellular Fractions / Q000201:enzymology
D004123:Dimethylamines; D009601:Nitroreductases; C013962:dimethylnitramine; D004128:Dimethylnitrosamine