Iohexol clearance for the determination of glomerular filtration rate in clinical practice: evidence for a new gold standard.
X-ray fluorescence analysis provides a simple method of measuring glomerular filtration rate from the clearance of ordinary unlabeled radiographic contrast media. To measure the accuracy of iohexol clearance using a clinically simple 2-sample single injection technique, a comparison was made in 30 patients with classical continuous infusion techniques for plasma (y = 1.03x - 0.015, r = 0.981) and renal (y = 0.950x + 7.26, r = 0.964) iohexol clearance. A comparison was made with classical inulin clearance. The renal clearance of iohexol and inulin was virtually identical (y = 0.998x + 2.31, r = 0.986). Single injection iohexol clearance agreed closely with the renal inulin clearance (y = 0.947x + 4.92, r = 0.983) as did clearance based on a single 3-hour sample (y = 0.875x + 12.63, r = 0.962). Iohexol clearance using x-ray fluorescence is a simple, rapid and accurate alternative to inulin clearance for clinical and research purposes.
Brown
S C
SC
Department of Urology, Stepping Hill Hospital, Stockport, United Kingdom.
O'Reilly
P H
PH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007444:Inulin; D007472:Iohexol / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D013052:Spectrometry, X-Ray Emission
D007472:Iohexol; D007444:Inulin