title: Ba2+ current oscillation evoked by bradykinin in ras-transformed fibroblasts.
abstract: By voltage-clamp recording, we show a novel inward current which oscillates after activation with bradykinin or serum in v-Ki-ras-transformed NIH/3T3 cells. The current oscillation was infrequently observed in control NIH/3T3 fibroblasts. The same stimulation evokes Ca2+ oscillations in the ras-transformed cells but not in parental cells (Fu et al., FEBS Lett. 281, 263-266, 1991). The results suggest that the oscillatory currents are generated by influxes of divalent cations to maintain Ca2+ oscillations in ras-transformed NIH/3T3 cells.
authors.affiliation: Department of Biophysics, Kanazawa University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Higashida
authors.forename: N
authors.initials: N
authors.lastname: Hoshi
authors.forename: M
authors.initials: M
authors.lastname: Hashii
authors.forename: T
authors.initials: T
authors.lastname: Fu
authors.forename: M
authors.initials: M
authors.lastname: Noda
authors.forename: Y
authors.initials: Y
authors.lastname: Nozawa
mesh_terms: D000818:Animals; D001464:Barium / Q000378:metabolism*; D001920:Bradykinin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D011905:Genes, ras; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D009532:Nickel / Q000494:pharmacology
chemical_list: D001464:Barium; D009532:Nickel; D001920:Bradykinin; D002118:Calcium