title: Acquired immunity to Toxocara canis infection in mice.
abstract: Acquired immunity develops against Toxocara canis infection in mice, and NIH mice are more immunoresponsive than CD1 mice. Twice infected NIH female mice showed 27% reduction in the total larval recoveries compared with non-sensitized controls. Twice-infected NIH male, and CD1 (both sexes) mice showed a negligible reduction in the total recoveries, though a significant (P less than 0.05) number of larvae were retained in the liver compared with the non-sensitized controls. All twice-infected mice showed a significant reduction in the number of larvae recovered from the brain compared with once-infected mice. Vaccination using ultraviolet irradiated embryonated eggs gave the best protection against reinfection. Excretory/secretory antigen afforded less protection, whilst whole adult worm vaccine and whole L2 culture vaccine gave no protection. Vaccinated mice had a higher 'free:penetrating ratio' of larvae in their intestine than similarly challenged but non-vaccinated mice. When the ileum was examined histologically 9 h post-infection, an inflammatory reaction was seen around the penetrating larvae in the sensitized and vaccinated mice but not in untreated controls, suggesting a role played by the intestine in the resistance against T. canis infection in mice.
authors.affiliation: School of Animal Biology, University College of North Wales, Bangor, UK.
authors.forename: M N
authors.initials: MN
authors.lastname: Abo-Shehada
authors.forename: B A
authors.initials: BA
authors.lastname: al-Zubaidy
authors.forename: I V
authors.initials: IV
authors.lastname: Herbert
mesh_terms: D000818:Animals; D001921:Brain / Q000469:parasitology; D005260:Female; D007110:Immunity, Active; D007814:Larva / Q000276:immunology / Q000502:physiology; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice / Q000469:parasitology*; D012376:Rodent Diseases / Q000276:immunology* / Q000517:prevention & control; D014119:Toxocara / Q000276:immunology* / Q000502:physiology; D014120:Toxocariasis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D014611:Vaccination / Q000662:veterinary*; D014612:Vaccines / Q000276:immunology
chemical_list: D014612:Vaccines