title: The stability of carboplatin, diamorphine, 5-fluorouracil and mitozantrone infusions in an ambulatory pump under storage and prolonged 'in-use' conditions.
abstract: Drug infusions can be exposed for prolonged periods to 'in-use' conditions where the temperature of an infusion in a holster-worn infusion pump may reach 37 degrees C. In this study, the stability of three cytotoxic drug infusions (carboplatin, 5-fluorouracil and mitozantrone) and one analgesic infusion (diamorphine HCl) was determined in Parker Micropump medication reservoirs under refrigerated storage and prolonged in-use conditions. The stability of the three cytotoxic drug infusions was unaffected by 14 days storage at either 4 or 37 degrees C. The diamorphine HCl infusion was stable over 14 days storage at 4 degrees C but under in-use conditions at 37 degrees C, drug degradation became significant (greater than 5%) if storage exceeded 7 days.
authors.affiliation: FORCE Cancer Research Centre, University of Exeter, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Northcott
authors.forename: M A
authors.initials: MA
authors.lastname: Allsopp
authors.forename: H
authors.initials: H
authors.lastname: Powell
authors.forename: G J
authors.initials: GJ
authors.lastname: Sewell
mesh_terms: D016190:Carboplatin / Q000008:administration & dosage / Q000032:analysis; D004355:Drug Stability; D004356:Drug Storage; D005472:Fluorouracil / Q000008:administration & dosage / Q000032:analysis; D003932:Heroin / Q000008:administration & dosage / Q000032:analysis; D007260:Infusion Pumps; D008942:Mitoxantrone / Q000008:administration & dosage / Q000032:analysis; D013696:Temperature
chemical_list: D003932:Heroin; D016190:Carboplatin; D008942:Mitoxantrone; D005472:Fluorouracil