Differential response of serum alkaline phosphatase and serum osteocalcin in Paget's osteosarcoma.
Serum osteocalcin did not show any response to the onset of osteosarcoma in Paget's disease of bone whereas serum alkaline phosphatase increased rapidly. This suggests that osteocalcin is not useful in the diagnosis and management of Paget's osteosarcoma and does not reflect the same osteoblastic processes in bone as serum alkaline phosphatase.
Davie
M W
MW
Charles Salt Research Centre, Robert Jones and Agnes Hunt Hospital, Oswestry, Shropshire, UK.
Worsfold
M
M
Sharp
C A
CA
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D014408:Biomarkers, Tumor; D001859:Bone Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D010001:Osteitis Deformans / Q000175:diagnosis*; D015675:Osteocalcin / Q000097:blood*; D012516:Osteosarcoma / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D015675:Osteocalcin; D000469:Alkaline Phosphatase