title: Infant diet and salmonellosis.
abstract: BACKGROUND
  The Island of Guam has experienced a high incidence of infant salmonellosis for a number of years (age-specific incidence rate of approximately 3700 cases per 100,000 infants in 1984). Interviews of case parents suggested that the use of high-iron infant formula was associated with this problem.
  
  
  METHODS
  A case-control study was conducted to test this hypothesis. Information on feeding practices and a variety of medical and socioeconomic factors was collected for 78 laboratory-confirmed Salmonella-case infants and 167 control infants.
  
  
  RESULTS
  Case infants were less likely to have been breast-fed (odds ratio [OR] = 9.15; 95% confidence interval [CI] = 2.71-30.9) and more likely to have been fed infant formula with an iron content of 10 mg/L or greater (OR = 2.96; 95% CI = 1.24-7.08) than were control infants.
  
  
  CONCLUSIONS
  Although the precise means by which infants are most commonly exposed to Salmonella bacteria remain obscure, breast-feeding apparently protects against the development of physician-diagnosed clinical salmonellosis, while the feeding of high-iron infant formula has the opposite effect.
authors.affiliation: Department of Public Health and Social Services, Agana, Guam 96910.
authors.forename: R L
authors.initials: RL
authors.lastname: Haddock
authors.forename: S N
authors.initials: SN
authors.lastname: Cousens
authors.forename: C C
authors.initials: CC
authors.lastname: Guzman
mesh_terms: D001942:Breast Feeding; D005260:Female; D006141:Guam / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000009:adverse effects* / Q000032:analysis; D007231:Infant, Newborn; D007501:Iron / Q000032:analysis; D008297:Male; D012478:Salmonella Food Poisoning / Q000453:epidemiology / Q000209:etiology*; D012959:Socioeconomic Factors
chemical_list: D007501:Iron