title: Mitochondrial damage by active oxygen species in vitro.
abstract: Under in vitro conditions involving formation of active oxygen species, rat liver mitochondria were found to undergo swelling, peroxidative decomposition of lipids, and distinct disorganization of ultrastructure. Supplementation with free radical scavengers such as superoxide dismutase (SOD), methionine, histidine, and tryptophan accorded considerable protection to the organelle. A possible correlation between oxygen radicals, membrane integrity, and calcium functions is indicated.
authors.affiliation: Ecotoxicology Section, Industrial Toxicology Research Centre, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Mehrotra
authors.forename: P
authors.initials: P
authors.lastname: Kakkar
authors.forename: P N
authors.initials: PN
authors.lastname: Viswanathan
mesh_terms: D000818:Animals; D002122:Calcium Chloride / Q000633:toxicity; D005609:Free Radicals; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000473:pathology; D010100:Oxygen / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013858:Thiobarbiturates / Q000378:metabolism
chemical_list: D005609:Free Radicals; D013858:Thiobarbiturates; D008315:Malondialdehyde; C029684:thiobarbituric acid; D002122:Calcium Chloride; D010100:Oxygen