Successful stimulation of autologous bone marrow recovery by GM-CSF and IL-3 after an unrelated donor BMT for juvenile CML complicated by graft failure.
We report the case of a boy with juvenile chronic myeloid leukemia (jCML), who after initial treatment with interferon alpha-2 (IFN) and hydroxyurea underwent bone marrow transplantation (BMT) from a matched unrelated donor complicated by graft failure. Subsequent stimulation of hematopoiesis by GM-CSF and IL-3 promoted autologous recovery. In contrast to the course of disease pre-BMT, the boy is now off any therapy remaining in complete remission more than 500 days after BMT.
Suttorp
M
M
Dept. of Pediatrics, Univ. of Kiel, FRG.
Schmitz
N
N
Prange
E
E
Ganser
A
A
Löffler
H
H
Schaub
J
J
D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D016026:Bone Marrow Transplantation; D002470:Cell Survival; D003131:Combined Modality Therapy; D004357:Drug Synergism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use*; D007223:Infant; D007370:Interferon Type I / Q000627:therapeutic use; D007377:Interleukin-3 / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000601:surgery* / Q000628:therapy; D008297:Male; D012074:Remission Induction
D007155:Immunologic Factors; D007370:Interferon Type I; D007377:Interleukin-3; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006918:Hydroxyurea