Acetylcholine vasodilation of resistance vessels in vivo may not entirely depend on newly synthesized nitric oxide.
Blood flow was measured in denervated hind limbs of pentobarbital-anesthetized cats. Intravenous NG-methyl-L-arginine, 3-30 mg/kg did not affect the magnitude or duration of vasodilation produced by intra-arterial acetylcholine. Intra-arterial NG-methyl-L-arginine induced hind limb vasoconstriction and reduced the duration but not the magnitude of the acetylcholine vasodilator response. The results suggest that acetylcholine-induced hind limb vasodilation may not entirely depend on newly synthesized nitric oxide.
Ross
G
G
Department of Physiology, UCLA School of Medicine 90024.
Chaudhuri
G
G
Ignarro
L J
LJ
Chyu
K Y
KY
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003714:Denervation; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006614:Hindlimb / Q000098:blood supply; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism / Q000502:physiology*; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*; D019323:omega-N-Methylarginine
D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D001120:Arginine; D000109:Acetylcholine