[Diffusion of norfloxacin in epididymal tissue].
Norfloxacin, a "second generation" compound of the quinolone group, was administered orally, before surgery, every 12 h during successive three-day periods at dose of 400 mg to ten patients hospitalized for prostatic adenoma or for prostatic cancer. On the day of surgery, a 400 mg-last dose was administered. Unchanged norfloxacin was assayed by high performance liquid chromatography with fluorescence detection. The Cmin value was 1.2 +/- 0.77 mg/l. Concurrent norfloxacin concentrations in plasma and epididymal tissue (left and right) were determined, about 4 h after the last drug intake, the epididymal level was 3.4 +/- 1.9 micrograms/g. This value was above the MIC90 for most sensitive organisms. The ratio (+/- SD) of drug concentration in epididymal tissue and in plasma was 3. 74 +/- 2.10 (range 1.66-10.2). The epididymal level of norfloxacin was strongly correlated with, area under curve (p less than 0.001) and plasma concentration (p less than 0.01).
Blondin
C
C
Laboratoire de Pharmacocinétique, CHRU, Nîmes.
Costa
P
P
Bressolle
F
F
Galtier
M
M
D000368:Aged; D000369:Aged, 80 and over; D004058:Diffusion; D004822:Epididymis / Q000187:drug effects* / Q000378:metabolism; D004823:Epididymitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D009643:Norfloxacin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011300:Preoperative Care; D011471:Prostatic Neoplasms / Q000601:surgery*
D009643:Norfloxacin
Etude de la diffusion épididymaire de la norfloxacine.