title: Intrapleural bupivacaine analgesia after thoraco-abdominal incision for oesophagectomy.
abstract: Intrapleural bupivacaine administration is said to produce good analgesia for the pain induced by a subcostal incision. However, reports of its efficacy after thoracotomy are conflicting. The goal of this study was to compare the analgesia produced by intrapleural administration of bupivacaine after oesophagectomy using a thoraco-abdominal incision with that obtained from intrapleural saline. After informed consent and institutional approval were obtained, 20 patients were randomly assigned to two groups of 10 patients each. Subjects received intrapleurally 10 ml of either 0.25% bupivacaine with 1:200,000 adrenaline or normal saline, every 8 h, beginning on the first post-operative day and lasting for 4 days. Pain was evaluated using a visual-analogue scale 2 h after the first daily treatment at rest and during physiotherapy. Pain scores were significantly lower in the bupivacaine group than in the saline group. Additionally, PaO2 was significantly higher in the bupivacaine group than in the saline group on Day 1 (P less than 0.05). The plasma bupivacaine concentration never reached the level of toxicity. Plasma bupivacaine concentrations on Day 1 after the first intrapleural bupivacaine injection were less than 350 ng ml-1; on Day 4 after the last injection they were less than 1300 ng ml-1. In conclusion, intrapleural administration of bupivacaine produces effective analgesia after oesophagectomy performed with a thoracoabdominal incision. The technique is easy to perform and is safe.
authors.affiliation: Department of Anesthesiology, Hôpital Côte de Nacre, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Tartiere
authors.forename: D
authors.initials: D
authors.lastname: Samba
authors.forename: C
authors.initials: C
authors.lastname: Lefrancois
authors.forename: J P
authors.initials: JP
authors.lastname: Deshayes
authors.forename: K
authors.initials: K
authors.lastname: Samii
authors.forename: H
authors.initials: H
authors.lastname: Bricard
authors.forename: J
authors.initials: J
authors.lastname: Quesnel
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use; D000698:Analgesia / Q000379:methods*; D002045:Bupivacaine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D015505:Chest Tubes; D004311:Double-Blind Method; D004947:Esophagus / Q000601:surgery*; D005260:Female; D006801:Humans; D007267:Injections; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D026741:Physical Therapy Modalities; D010994:Pleura; D013908:Thoracotomy / Q000009:adverse effects*
chemical_list: D000082:Acetaminophen; D002045:Bupivacaine