title: [T lymphoid blast crisis of Philadelphia chromosome-positive chronic myeloid leukemia: analysis of 3 cases].
abstract: BACKGROUND
  To investigate the frequency of the T lymphoid phenotype in the blast crisis of chronic myelocytic leukemia (CML) with positive Philadelphia chromosome (Ph) and to evaluate the major clinical and hematologic features of the patients with this phenotype.
  
  
  METHODS
  The presence of the TdT enzyme was assessed and specific monoclonal antibodies to the different hemopoietic lines were used to evaluate blast cells in 38 patients with blast crisis during Ph-positive CML.
  
  
  RESULTS
  T lymphoid phenotype was found in three of the 38 patients, corresponding in all cases to immature T cells. In one patient, the blast crisis was the presenting feature of CML and in two the localization of the blast crisis was lymphadenopathic. In the two patients who could be followed up a favorable response to chemotherapy regimens including vincristine and prednisone was observed.
  
  
  CONCLUSIONS
  Although uncommon, T lymphoid blast crisis in CML should no longer be considered exceptional. This phenotypic finding suggests that, at least in some cases, CML originates in a pluripotential stem cell common to all hemopoietic cells, including T lymphocytes.
authors.affiliation: Escuela de Hematología Farreras Valenti, Hospital Clinic i Provincial, Barcelona.
authors.forename: F
authors.initials: F
authors.lastname: Cervantes
authors.forename: A
authors.initials: A
authors.lastname: Urbano-Ispizua
authors.forename: L
authors.initials: L
authors.lastname: Escoda
authors.forename: J
authors.initials: J
authors.lastname: Ordi
authors.forename: E
authors.initials: E
authors.lastname: Montserrat
authors.forename: C
authors.initials: C
authors.lastname: Rozman
mesh_terms: D000328:Adult; D001752:Blast Crisis / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011241:Prednisone / Q000627:therapeutic use; D013601:T-Lymphocytes; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D011241:Prednisone
vernacular_title: Crisis blástica linfoide T de la leucemia mieloide crónica cromosoma Filadelfia positiva: análisis de tres casos.