Long-term follow-up of children born to women immunized with tetanus toxoid during pregnancy.
Ten years after transplacental immunization with tetanus toxoid, the antibody responses of the immunized children to a booster immunization with 5 Lf tetanus toxoid did not differ from those of the control children. The tetanus toxoid-stimulated lymphocyte proliferative responses showed that there was no tolerance to tetanus toxoid induced by transplacental immunization, and the stimulation indices suggested that there may be some long-term memory for tetanus toxoid among the T lymphocytes in children who had been transplacentally immunized by maternal immunization with a standard dose of tetanus toxoid.
Gill
T J
TJ
Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15261.
Karasic
R B
RB
Antoncic
J
J
Rabin
B S
BS
D000907:Antibodies, Bacterial / Q000032:analysis*; D002648:Child; D005260:Female; D005333:Fetus / Q000276:immunology*; D005500:Follow-Up Studies; D006801:Humans; D007114:Immunization; D007156:Immunologic Memory; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013745:Tetanus Toxoid / Q000276:immunology*
D000907:Antibodies, Bacterial; D013745:Tetanus Toxoid