Involvement of the dorsal hippocampus in mediation of the antianxiety action of tandospirone, a 5-hydroxytryptamine1A agonistic anxiolytic.
The effect of tandospirone, a 5-hydroxytryptamine (5-HT)1A agonist/anxiolytic, injected directly into dorsal hippocampus, on Vogel-type conflict behavior in rats was investigated and the findings were compared with the effects of diazepam and zopiclone. Tandospirone (30 micrograms/2 microliters and 60 micrograms/2 microliters) and diazepam (40 micrograms/2 microliters) but not zopiclone (20 micrograms/2 microliters), produced a potent anticonflict action in rats. The anticonflict action of tandospirone (30 micrograms/2 microliters), injected into the dorsal hippocampus, was significantly blocked by (-)-propranolol (5 mg/kg i.p.). The present findings provide evidence that suggests that tandospirone has an antianxiety action, presumably by stimulating 5-HT1A receptors in the dorsal hippocampus.
Kataoka
Y
Y
Department of Pharmacology, Nagasaki University School of Medicine, Japan.
Shibata
K
K
Miyazaki
A
A
Inoue
Y
Y
Tominaga
K
K
Koizumi
S
S
Ueki
S
S
Niwa
M
M
D000818:Animals; D001007:Anxiety / Q000188:drug therapy*; D053961:Azabicyclo Compounds; D001522:Behavior, Animal / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects*; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007267:Injections; D054833:Isoindoles; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012702:Serotonin Antagonists / Q000494:pharmacology*
D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D054833:Isoindoles; D010879:Piperazines; D011743:Pyrimidines; D012702:Serotonin Antagonists; C515050:zopiclone; C055267:tandospirone; D003975:Diazepam