Effect of an inhibitor of PGE (flurbiprofen) on colony growth from normal and leukemic peripheral leukocytes in basal conditions and in presence of testosterone or cortisol.
The Authors have controlled the colony growth in coltures from peripheral leukocytes of normal subjects and from patients with CML and AML. The cultures were prepared on double agar layer in basal conditions and after adding flurbiprofen and/or cortisol and/or testosterone. The exam of the plates has shown a light similar stimulating activity on the growth of all substances separately considered, with and evidence ability of flurbiprofen of potentiate the action of the two hormones, both in coltures from normal and leukemic peripheral leukocyte CFU-GM.
Carisdeo
V
V
Department of Internal Medicine and Medical Therapy, University of Pavia, Italy.
Messina
S
S
Qalqili
A
A
D002478:Cells, Cultured; D005480:Flurbiprofen / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007938:Leukemia / Q000097:blood*; D007962:Leukocytes / Q000187:drug effects*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors*; D013739:Testosterone / Q000494:pharmacology*
D011458:Prostaglandins E; D013739:Testosterone; D005480:Flurbiprofen; D006854:Hydrocortisone