title: Immunological markers in the cerebrospinal fluid of HIV-1-infected children.
abstract: Several immunological abnormalities were detected in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected children. Intrathecal synthesis of immunoglobulins, free light chains (FLC), IL-1 beta, IL-6, and M-CSF were demonstrated both in asymptomatic children and children with subacute encephalopathy. Our findings further support the hypothesis that an immunopathological subclinical process within the central nervous system (CNS) may be an early manifestation of acquired immunodeficiency syndrome (AIDS). Cytokine detection in the CSF may represent a useful diagnostic tool in evaluating the outcome of HIV-1-infected patients.
authors.affiliation: Institute of Neurology, Interuniversity Center for Research on Cancer, Padua, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Gallo
authors.forename: A M
authors.initials: AM
authors.lastname: Laverda
authors.forename: A
authors.initials: A
authors.lastname: De Rossi
authors.forename: S
authors.initials: S
authors.lastname: Pagni
authors.forename: A
authors.initials: A
authors.lastname: Del Mistro
authors.forename: P
authors.initials: P
authors.lastname: Cogo
authors.forename: M G
authors.initials: MG
authors.lastname: Piccinno
authors.forename: A
authors.initials: A
authors.lastname: Plebani
authors.forename: B
authors.initials: B
authors.lastname: Tavolato
authors.forename: L
authors.initials: L
authors.lastname: Chieco-Bianchi
mesh_terms: D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000188:drug therapy; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002675:Child, Preschool; D016207:Cytokines / Q000134:cerebrospinal fluid* / Q000378:metabolism; D005260:Female; D015497:HIV-1; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008297:Male; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D016207:Cytokines; D015215:Zidovudine