[Bioavailability of griseofulvin in the form of liposomes].
Liposomes containing griseofulvin have been prepared by shaking method. Lecithin and cholesterol were used to compose phospholipid bilayer of liposomes. The suspension of liposomes in 0.9% sodium chloride and the suspension of griseofulvin in 0.25% iostonic methylcellulose solution were used in the comparative study in vivo. Both suspensions were administered intragastricly to rats. Parameters of bioavailability have been found on the basis of the changes in griseofulvin plasma concentrations versus time. Intragastric administration of griseofulvin in liposomes suspension demonstrates ca. 40% higher Cmax and AUC when compared to these of griseofulvin suspension which indicates a better bioavailability.
Stozek
T
T
Lehrstuhl für Pharmazeutische Technologie und Biopharmazie, Medizinischen Akademie Kraków, Polen.
Borysiewicz
J
J
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002784:Cholesterol / Q000737:chemistry; D006118:Griseofulvin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008081:Liposomes; D008297:Male; D010713:Phosphatidylcholines / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains
D008081:Liposomes; D010713:Phosphatidylcholines; D006118:Griseofulvin; D002784:Cholesterol
Bioverfügbarkeit von Griseofulvin in Form von Liposomen.