Localization of the human gene for 230-kDal bullous pemphigoid autoantigen (BPAG1) to chromosome 6pter----q15.
Chromosome mapping of the human gene encoding the 230-kDal autoantigen of an autoimmune skin disease, bullous pemphigoid, was performed using flow-sorted human chromosomes of cells of normal karyotype and cells carrying a reciprocal translocation t(6;16)(q15;q24). The cDNA of the autoantigen hybridized with intact chromosome 6 and translocation chromosome 6p- (6pter----q15::16q24----qter). The gene (BPA230) was located to the chromosome region 6pter----q15.
Minoshima
S
S
Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan.
Amagai
M
M
Kudoh
J
J
Fukuyama
R
R
Hashimoto
T
T
Nishikawa
T
T
Shimizu
N
N
D000818:Animals; D001324:Autoantigens / Q000235:genetics*; D002352:Carrier Proteins; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D003094:Collagen; D003598:Cytoskeletal Proteins; D004247:DNA / Q000235:genetics; D000071821:Dystonin; D006801:Humans; D007621:Karyotyping; D051379:Mice; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D009693:Nucleic Acid Hybridization; D010391:Pemphigoid, Bullous / Q000276:immunology*; D014178:Translocation, Genetic; D000097805:Collagen Type XVII
D001324:Autoantigens; D002352:Carrier Proteins; D003094:Collagen; D003598:Cytoskeletal Proteins; D004247:DNA; D000071821:Dystonin; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII; C486268:DST protein, human; C095667:Dst protein, mouse