Clinical studies of omega-3 fatty acid supplementation in patients who have rheumatoid arthritis.
Several studies have now demonstrated reproducible clinical benefits of rheumatoid arthritis disease activity after ingestion of n-3 fatty acids. Biologic changes induced by fish oils include decreases in the production of leukotriene B4, platelet activating factor and interleukin-1. Investigations now focus on the proper dose and duration of fish-oil dietary intervention in order to obtain optimum clinical effects. Their ultimate therapeutic role has not yet been determined.
Kremer
J M
JM
Albany Medical College, New York.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005395:Fish Oils / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D006801:Humans; D010865:Pilot Projects; D011446:Prospective Studies
D015525:Fatty Acids, Omega-3; D005395:Fish Oils