title: Clinical evaluation of the effects of storage time and irradiation on transfused platelets.
abstract: Platelet concentrates stored for up to 5 days at room temperature or irradiated with 15 Gy immediately prior to transfusion were evaluated for their ability to increase the platelet count in thrombocytopenic patients. Platelets irradiated with a dose of 15 Gy immediately prior to transfusion achieved corrected increments (CI) at 1 and 20 h after transfusion no different from those achieved by non-irradiated platelets. Storage for 5 days reduced the mean 1-hour CI to 5.7 compared with a mean of 12.3 achieved by platelets transfused after only 1-day storage (p = 0.008). Similarly, the frequency of a repeat transfusion being indicated within 24 h increased with increasing storage time (p = 0.005).
authors.affiliation: Mersey and North Wales Regional Transfusion Service, Royal Liverpool Hospital, UK.
authors.forename: J K
authors.initials: JK
authors.lastname: Duguid
authors.forename: R
authors.initials: R
authors.lastname: Carr
authors.forename: J A
authors.initials: JA
authors.lastname: Jenkins
authors.forename: J L
authors.initials: JL
authors.lastname: Hutton
authors.forename: G F
authors.initials: GF
authors.lastname: Lucas
authors.forename: J M
authors.initials: JM
authors.lastname: Davies
mesh_terms: D001792:Blood Platelets / Q000528:radiation effects; D001793:Blood Preservation; D001803:Blood Transfusion; D006801:Humans; D017713:Platelet Transfusion; D013997:Time Factors