Fluvirucins A1, A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza A virus. III. The stereochemistry and absolute configuration of fluvirucin A1.
Fluvirucin A1 was established as (2R,3S,6R, 10S)-3-[(3-amino-3,6-dideoxy-alpha-L-talopyranosyl)-oxy]-2,6-dimethyl-10 -ethyl-13-tridecanelactam by chemical, spectroscopic, and X-ray crystallographic analyses.
Naruse
N
N
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Konishi
M
M
Oki
T
T
Inouye
Y
Y
Kakisawa
H
H
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003837:Deoxy Sugars / Q000737:chemistry*; D009980:Influenza A virus / Q000187:drug effects*; D007769:Lactams / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D003837:Deoxy Sugars; D007769:Lactams; C070542:fluvirucin A1