Prostaglandin synthesis is increased in selenium supplemented human mesangial cells despite suppression of phospholipase A2-activity.
Antioxidants play an important role in the regulation of phospholipid hydrolysis and arachidonate metabolism. Supplementation of cultured human mesangial cells with selenium resulted in suppression of phospholipase A2-activity and significantly increased production of three major prostaglandins. However, prostacyclin synthesis benefits most from selenium supplementation, suggesting that there is a specific action of selenium-dependent glutathione peroxidase on this pathway. Like in endothelial cells, production of platelet activating factor is significantly inhibited by selenium supplementation.
Hampel
G
G
Department of Clinical Pathology, University of Erlangen-Nürnberg, FRG.
Reinke
M
M
Hren
J
J
D002478:Cells, Cultured; D005920:Glomerular Mesangium / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D010972:Platelet Activating Factor / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D012643:Selenium / Q000494:pharmacology*
D010972:Platelet Activating Factor; D011453:Prostaglandins; D005979:Glutathione Peroxidase; D010741:Phospholipases A; D054467:Phospholipases A2; D012643:Selenium