[The acceleration of experimental influenza B infection under the influence of gangliosides].
The influence of mono-, di-, and trisialogangliosides on the dynamics of influenza B virus reproduction in human embryo fibroblast (HEF) cell culture and human diploid cells was established. The cells were treated with neuraminidase of non-cholera vibrio for removal of natural receptors followed by treatment with gangliosides. Virus reproduction was assessed by infectious titres for chick embryos and HA test of the culture fluid at certain intervals. Gangliosides restored influenza virus reception and enhanced the infectious process as compared with the controls. Treatment with gangliosides of HEF culture of low sensitivity increased its susceptibility to virus markedly.
Danlybaeva
G A
GA
Podcherniaeva
R Ia
RIa
Filippova
M M
MM
Bukrinskaia
A G
AG
D000327:Adsorption; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian; D005732:Gangliosides / Q000494:pharmacology*; D006801:Humans; D009981:Influenza B virus / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D007251:Influenza, Human / Q000382:microbiology*; D009439:Neuraminidase / Q000494:pharmacology; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic / Q000187:drug effects; D014733:Vibrio / Q000201:enzymology; D014776:Virus Cultivation / Q000379:methods; D014779:Virus Replication / Q000187:drug effects
D005732:Gangliosides; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C034993:ganglioside receptor; C025447:sialogangliosides; D009439:Neuraminidase
Uskorenie éksperimental'noĭ grippoznoĭ B infektsii pod vliianiem gangliozidov.