[Experimental premises and 1st experiences in the clinical use of antibacterial vascular prostheses under circumstances of increased risk of suppuration].
It was shown on the basis of laboratory and experimental data that created antibacterial vascular prostheses are marked, on the main, by local bacteriostatic and anticoagulative effect. It was found that heparin concentration of 3 to 500 U per 1 kg collagen causes a hyperadhesive effect on blood platelets and facilitates the formation of the primary thrombocytic thrombus. The free surface energy grows in this case from 34 +/- 0.8 to 66.3 +/- erg/cm2. The optimal thromboresistant effect occurs in heparin content of 1 U per 1 mg collagen. That this choice is correct is confirmed on examination of the inner surface of the prostheses with an electron microscope after being in the blood flow for 45 minutes. Bifurcation and linear antibacterial prostheses were used in 9 patients with a high risk of suppuration verified by cultures of discharge from ulcers and lymph nodes, and the presence of lymphangitis and lymphadenitis. The effect was positive in 8 patients, 2 of them had superficial suppuration of the operative wounds.
Dronov
A F
AF
Lipskaia
G F
GF
Rudenko
T G
TG
Aboiants
R K
RK
Istranov
L P
LP
Mamedov
D M
DM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D005839:Gentamicins / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008199:Lymphadenitis / Q000150:complications; D008205:Lymphangitis / Q000150:complications; D008297:Male; D051381:Rats; D012307:Risk Factors; D013492:Suppuration; D013530:Surgical Wound Infection / Q000150:complications
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D006493:Heparin
Eksperimental'nye predposylki i pervyĭ opyt klinicheskogo primeneniia antibakterial'nykh sosudistykh protezov v usloviiakh povyshennogo riska nagnoeniia.