title: Wound management with N-carboxybutyl chitosan.
abstract: In patients undergoing plastic surgery, donor sites were treated with soft pads of freeze-dried N-carboxybutyl chitosan to promote ordered tissue regeneration. Compared to control donor sites, better histoarchitectural order, better vascularization and the absence of inflammatory cells were observed at the dermal level, whilst fewer aspects of proliferation of the malpighian layer were reported at the epidermal level. Accordingly, N-carboxybutyl chitosan leads to formation of regularly organized cutaneous tissue and reduces anomalous healing.
authors.affiliation: Institute of Human Morphology, Faculty of Medicine, University of Ancona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Biagini
authors.forename: A
authors.initials: A
authors.lastname: Bertani
authors.forename: R
authors.initials: R
authors.lastname: Muzzarelli
authors.forename: A
authors.initials: A
authors.lastname: Damadei
authors.forename: G
authors.initials: G
authors.lastname: DiBenedetto
authors.forename: A
authors.initials: A
authors.lastname: Belligolli
authors.forename: G
authors.initials: G
authors.lastname: Riccotti
authors.forename: C
authors.initials: C
authors.lastname: Zucchini
authors.forename: C
authors.initials: C
authors.lastname: Rizzoli
mesh_terms: D000328:Adult; D001684:Biological Dressings; D002686:Chitin / Q000031:analogs & derivatives*; D048271:Chitosan; D003094:Collagen / Q000648:ultrastructure; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012867:Skin / Q000648:ultrastructure*; D016038:Skin Transplantation / Q000379:methods* / Q000502:physiology; D013518:Surgery, Plastic / Q000379:methods*; D013848:Thigh; D014945:Wound Healing / Q000502:physiology*
chemical_list: C067347:N-carboxybutyl chitosan; D002686:Chitin; D003094:Collagen; D048271:Chitosan