title: Reduction of bronchial responsiveness to methacholine after mitral valve replacement.
abstract: Sixteen patients with mitral valve disease, in whom bronchial hyperresponsiveness to methacholine had been detected shortly before mitral valve replacement (MVR), were reevaluated 35 +/- 1.5 months after MVR. In 9/16 patients there was a significant (greater than 1.5 fold) increase in bronchial provocation dose of methacholine (PD20FEV1) after MVR. In the same patients there was a significant increase in vital capacity (from 69.6 +/- 5 to 75.8 +/- 5.2% of predicted, p less than 0.01), a significant decrease in cardiothoracic ratio and in radiologic score for lung edema (from 64.3 +/- 2.9 to 56 +/- 2.1, p less than 0.01 and from 38 +/- 4.5 to 14.6 +/- 2, p less than 0.001, respectively). In all the patients the increase in PD20FEV1 was not related to any change in spirometric values but it was related to the decrease in cardiothoracic index (r = 0.72, p less than 0.01) and in radiologic score for lung edema (r = 0.61, p less than 0.05) observed after cardiosurgery.
authors.affiliation: Clinica Medica I dell'Università di Torino, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Rolla
authors.forename: C
authors.initials: C
authors.lastname: Bucca
authors.forename: L
authors.initials: L
authors.lastname: Brussino
authors.forename: P
authors.initials: P
authors.lastname: Costa
authors.forename: M
authors.initials: M
authors.lastname: Morea
mesh_terms: D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005541:Forced Expiratory Volume / Q000502:physiology; D006350:Heart Valve Prosthesis; D006801:Humans; D008449:Maximal Expiratory Flow-Volume Curves / Q000502:physiology; D016210:Methacholine Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D015203:Reproducibility of Results; D013147:Spirometry; D014797:Vital Capacity / Q000502:physiology
chemical_list: D016210:Methacholine Chloride