[The characteristics of the cardioprotective action of fructose-1,6-diphosphate].
The cardioprotective effects of fructose-1,6-diphosphate (FDP) were investigated in infarcted rats and in conscious rabbits with myocardial ischemia. The influence of FDP on metabolic acidosis was studied in isolated hypoxic rat hearts. It was shown that FDP did not change the threshold of the initiation of ischemia in conscious rabbits, but decreased necrotic zone in infarcted rat hearts. After administration of FDP the myocardial contractility was prolonged significantly as compared with control under conditions of severe metabolic acidosis. However, FDP was not effective in hypoxic hearts with compensated metabolic acidosis. It was considered, that FDP influenced only ischemic myocytes with the changes in sarcolemmal permeability.
Sernov
L N
LN
Rozonov
Iu B
IuB
Sokolova
O A
OA
Shal'neva
T V
TV
Snegireva
G V
GV
Gatsura
V V
VV
D000138:Acidosis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005635:Fructosediphosphates / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D002317:Cardiovascular Agents; D005635:Fructosediphosphates; C029063:fructose-1,6-diphosphate
Osobennosti kardioprotektornogo deĭstviia fruktozo-1,6-difosfata.