title: Antibacterial activity of cefoperazone and cefoperazone plus sulbactam in a neutropenic site model.
abstract: Efficacy of cefoperazone versus cefoperazone plus sulbactam was studied in a rabbit neutropenic site infection model against a broad range of clinical isolates including six isolates each of staphylococci, enterococci, pneumococci, Enterobacteriaceae, and Pseudomonas aeruginosa. Therapy of cefoperazone plus sulbactam demonstrated enhanced efficacy against the staphylococci, pseudomonads, and Enterobacteriaceae. The activity of cefoperazone against enterococci and pneumococci was not enhanced or inhibited by the addition of sulbactam. Increased concentrations of cefoperazone found at the infection sites when sulbactam was added to the therapeutic regimen indicates that sulbactam provided a protection to cefoperazone from beta-lactamases produced by staphylococci and Enterobacteriaceae. The combination improved the efficacy of cefoperazone in this animal model.
authors.affiliation: Infectious Disease Section, Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417.
authors.forename: C E
authors.initials: CE
authors.lastname: Fasching
authors.forename: J A
authors.initials: JA
authors.lastname: Moody
authors.forename: L M
authors.initials: LM
authors.lastname: Sinn
authors.forename: J
authors.initials: J
authors.lastname: Tenquist
authors.forename: D N
authors.initials: DN
authors.lastname: Gerding
authors.forename: L R
authors.initials: LR
authors.lastname: Peterson
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D002438:Cefoperazone / Q000494:pharmacology / Q000627:therapeutic use*; D015194:Diffusion Chambers, Culture; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004755:Enterobacteriaceae / Q000187:drug effects; D009503:Neutropenia / Q000150:complications*; D011549:Pseudomonas / Q000187:drug effects; D011817:Rabbits; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013407:Sulbactam / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D002438:Cefoperazone; D013407:Sulbactam