[Changes in the receptor binding of dexamethasone and insulin by blood cells in rats after hydrocortisone administration in early postnatal ontogenesis].
A study was made of the effect of hydrocortisone, administered in early postnatal ontogenesis, on insulin and glucocorticoid reception in erythrocytes and mononuclear leukocytes. Hydrocortisone was administered to rat weanlings intraperitoneally at different ages of their life (5 days, 13, 15, 17 days, 1, 2 and 3 months). It has been assumed that extensive corticosteroid therapy resulting in prolonged imbalance of the level of the adrenocortical hormones and blood insulin, changes the receptor binding of these hormones on target cells as a result of a decrease in the hormone regulated receptor pool.
Tikhonova
N E
NE
Tatarinova
G Sh
GSh
Pivina
S G
SG
Shaliapina
V G
VG
D000305:Adrenal Cortex Hormones / Q000097:blood; D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D003907:Dexamethasone / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D051381:Rats; D011972:Receptor, Insulin / Q000097:blood / Q000187:drug effects*; D011965:Receptors, Glucocorticoid / Q000097:blood / Q000187:drug effects*
D000305:Adrenal Cortex Hormones; D007328:Insulin; D011965:Receptors, Glucocorticoid; C028697:dexamethasone receptor; D003907:Dexamethasone; D011972:Receptor, Insulin; D006854:Hydrocortisone
Izmenenie retseptornogo sviazyvaniia deksametazona i insulina kletkami krovi u krys posle vvedeniia gidrokortizona v rannem postnatal'nom ontogeneze.