[Endoscopic injection of liposomal adriamycin targeting lymph node metastasis of gastric cancer].
Gastric submucosal injection of 5 mg liposomal adriamycin (L-ADM) close to the main gastric cancer tumor was done in 15 patients by endoscopy. This approach was based on the idea that preoperative adjuvant chemotherapy targeting lymph node metastasis in patients with gastric cancer may be effective for prevention of lymph node recurrence. ADM concentrations in the regional lymph nodes were assessed and compared with those in patients who were administered 5 mg of free adriamycin (F-ADM) i.v. preoperatively. ADM concentrations in Group 7 lymph nodes (according to the General Rules for Gastric Cancer Study) were: After 2 days; 7.21 +/- 5.98 micrograms/g (n = 2) in the L-ADM group and 0.59 +/- 0.23 micrograms/g (n = 3) in the F-ADM group. After 4 days; 4.93 +/- 3.93 micrograms/g (n = 2) in the L-ADM group and 0.36 +/- 0.0 micrograms/g (n = 2) in the F-ADM group. After 6 days; 2.08 +/- 0.49 micrograms/g (n = 2) in the L-ADM group and 0.05 +/- 0.05 micrograms/g (n = 3) in the F-ADM group. L-ADM group: those who had L-ADM injected into the side of the lesser curvature of the stomach. F-ADM group: those who had F-ADM administered i.v. These data demonstrate that gastric submucosal injection of L-ADM is well suited for specific delivery to the regional lymph nodes, suggesting that this type of administration may prevent lymph node recurrence of gastric cancer by targeting lymph node metastasis.
Akamo
Y
Y
First Dept. of Surgery, School of Medicine, Nagoya City University.
Mizuno
I
I
Ichino
T
T
Yamamoto
T
T
Yasui
T
T
Itabashi
Y
Y
Saito
T
T
Kurahashi
S
S
Tanimoto
N
N
Shinagawa
N
N
D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D005753:Gastric Mucosa; D005773:Gastroscopy; D006801:Humans; D015552:Injections, Intralesional; D008081:Liposomes; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D004337:Drug Carriers; D008081:Liposomes; D004317:Doxorubicin