title: Osteoclast-like giant cell tumor of the pancreas: immunophenotypic similarity to giant cell tumor of bone.
abstract: An immunophenotype was performed on an osteoclast-like giant cell tumor of the pancreas using a panel of antibodies to epithelial and leukocyte antigens. Several antibodies to cytokeratin and carcinoembryonic antigen were negative in the tumor. Osteoclast-like cells were positive for CD4, CD13, CD45, CD68, CD71, and vimentin, but negative for lysozyme and HLA-DR. Mononuclear tumor cells were positive for CD4, CD11c, CD13, CD14, CD45, CD68, CD71, HLA-DR, and vimentin, but negative for lysozyme. The phenotype is similar to that previously described for giant cell tumor of bone. The osteoclast-like cell phenotype is also similar to that reported for normal osteoclasts. The findings support a nonepithelial origin for osteoclast-like giant cell tumor of the pancreas, and suggest a derivation similar to giant cell tumor of bone.
authors.affiliation: Department of Pathology, University of Chicago, IL 60637.
authors.forename: R D
authors.initials: RD
authors.lastname: Goldberg
authors.forename: F
authors.initials: F
authors.lastname: Michelassi
authors.forename: A G
authors.initials: AG
authors.lastname: Montag
mesh_terms: D015415:Biomarkers; D005870:Giant Cell Tumors / Q000737:chemistry* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D010010:Osteoclasts / Q000737:chemistry / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000737:chemistry* / Q000473:pathology*
chemical_list: D015415:Biomarkers