Newly generated IgE antibodies to Dermatophagoides pteronyssinus in children are directed against components distinct from Der p I and Der p II.
The specificity of newly generated IgE antibodies (Abs) to the house dust mite, Dermatophagoides pteronyssinus, in longitudinal serum samples from 18 young children with an increased risk for IgE-mediated allergy was studied. The first IgE Ab response to house dust mite was detected early in life (mean age, 32 months; range, 11 to 60 months). For 83% of the children, more than half of the newly generated IgE Ab response to house dust mite was directed against components distinct from the major allergens, Der p I (Pl) and Der p II (DpX). These results suggest that the early IgE Ab response to house dust mite is induced by components distinct from the major allergens, Der p I and Der p II.
Calkhoven
P G
PG
Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Aalbers
M
M
Schilte
P P
PP
Yntema
B J
BJ
Griffioen
R W
RW
van Nierop
J C
JC
Oranje
A P
AP
Aalberse
R C
RC
D000485:Allergens / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D002675:Child, Preschool; D004391:Dust; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000276:immunology; D007223:Infant; D008925:Mites / Q000276:immunology*; D011852:Radioallergosorbent Test
D000485:Allergens; D000906:Antibodies; D004391:Dust; D007073:Immunoglobulin E