title: Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks. II. Time hierarchy, enzymatic rate laws, and erythrocyte metabolism.
abstract: The multiobjective problem of minimizing all intermediate concentrations is solved for a model of glycolysis, the pentose monophosphate shunt and the glutathione system in human erythrocytes. It turns out that one solution out of four obtained corresponds qualitatively to the real system. Furthermore, it is shown that for any reaction system, the mentioned optimality principle implies distinct time hierarchy in that some reactions are infinitely fast and subsist in quasi-equilibrium. Finally, the relationships to the standard method of deriving enzymatic rate laws are discussed.
authors.affiliation: Humboldt-Universität zu Berlin, Sektion Biologie, Bereich Biophysik, Federal Republic of Germany.
authors.forename: S
authors.initials: S
authors.lastname: Schuster
authors.forename: R
authors.initials: R
authors.lastname: Schuster
authors.forename: R
authors.initials: R
authors.lastname: Heinrich
mesh_terms: D004734:Energy Metabolism; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D010084:Oxidation-Reduction