[Acceleration of the restoration of conditioned reflexes following anesthesia using aminostigmine].
The effect of anesthesia with ketamine (80 mg/kg, intraperitoneally) combined with phenazepam (0.5 mg/kg, subcutaneously) on the reproduction of an elaborated active avoidance reflex in automated reflexometer has been studied on random bred white rats. In has been shown that during 3 hours after the animal is taken out of the lateral position the degree of its learning is significantly lowered and does not return to baseline even a day later. Intramuscular administration of a new cholinesterase inhibitor aminostigmine right after the end of anesthesia restores the disrupted reflex in 3 hours. The optimal antistigmine dose is 0.015 mg/kg, which corresponds to a therapeutic human dose.
Prozorovskiĭ
V B
VB
Iudkina
N I
NI
D000768:Anesthesia, General; D000818:Animals; D002219:Carbamates; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D007649:Ketamine / Q000037:antagonists & inhibitors; D008297:Male; D011725:Pyridines; D011729:Pyridostigmine Bromide / Q000031:analogs & derivatives; D051381:Rats
D002219:Carbamates; D002800:Cholinesterase Inhibitors; D011725:Pyridines; C070102:aminostigmine; D007649:Ketamine; D011729:Pyridostigmine Bromide
Uskorenie vosstanovleniia uslovnykh refleksov posle narkoza ketaminom s pomoshch'iu aminostigmina.