title: DNA ploidy and cell kinetic measurements as predictors of recurrence and survival in stages B2 and C colorectal adenocarcinoma.
abstract: DNA content and cell proliferation were measured by flow cytometry on paraffin-embedded Stage B2 or C colorectal adenocarcinomas from 694 patients enrolled in adjuvant trials conducted by the North Central Cancer Treatment Group. Patients with diploid tumors had a higher survival rate than those with nondiploid tumors (P less than 0.001). The proliferation index (the sum of the percent of cells in S-phase plus those in G2M phase) was also a strong prognostic factor (P less than 0.001). The ploidy and proliferation data were combined, and the patients in the favorable group (diploid and low proliferative index) had a 5-year survival of 74% compared with 54% for the unfavorable group (high proliferative index or nondiploid, P less than 0.001). This grouping was prognostic for survival in B2 (P less than 0.001), C (P = 0.013), colon (P less than 0.001), and rectal (P = 0.026) patient subsets. This study indicates that cell kinetic parameters are important and independent prognostic factors for Stages B2 and C colorectal cancer.
authors.affiliation: Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: T E
authors.initials: TE
authors.lastname: Witzig
authors.forename: C L
authors.initials: CL
authors.lastname: Loprinzi
authors.forename: N J
authors.initials: NJ
authors.lastname: Gonchoroff
authors.forename: H M
authors.initials: HM
authors.lastname: Reiman
authors.forename: S S
authors.initials: SS
authors.lastname: Cha
authors.forename: H S
authors.initials: HS
authors.lastname: Wieand
authors.forename: J A
authors.initials: JA
authors.lastname: Katzmann
authors.forename: J K
authors.initials: JK
authors.lastname: Paulsen
authors.forename: C G
authors.initials: CG
authors.lastname: Moertel
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality* / Q000473:pathology*; D002455:Cell Division; D015179:Colorectal Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011003:Ploidies; D011379:Prognosis; D012008:Recurrence; D016019:Survival Analysis
chemical_list: D004273:DNA, Neoplasm