Hog cholera virus: molecular composition of virions from a pestivirus.
Virions from hog cholera virus (HCV), a member of the genus Pestivirus, were analyzed by using specific antibodies. The nucleocapsid protein was found to be a 14-kDa molecule (HCV p14). An equivalent protein could also be demonstrated for virions from another pestivirus, bovine viral diarrhea virus. The HCV envelope is composed of three glycoproteins, HCV gp44/48, gp33, and gp55. All three exist in the form of disulfide-linked dimers in virus-infected cells and in virions; HCV gp44/48 and gp55 each form homodimers, whereas gp55 is also found dimerized with gp33. Such complex covalent interactions between structural glycoproteins have not been described so far for any RNA virus.
Thiel
H J
HJ
Federal Research Centre for Virus Diseases of Animals, Tübingen, Federal Republic of Germany.
Stark
R
R
Weiland
E
E
Rümenapf
T
T
Meyers
G
G
D000956:Antigens, Viral / Q000737:chemistry; D002213:Capsid / Q000737:chemistry; D006692:Classical Swine Fever Virus / Q000032:analysis*; D004220:Disulfides; D015180:Electrophoresis, Gel, Two-Dimensional; D006023:Glycoproteins / Q000737:chemistry; D008970:Molecular Weight; D011233:Precipitin Tests; D014758:Viral Core Proteins / Q000737:chemistry; D014771:Virion / Q000032:analysis*
D000956:Antigens, Viral; D004220:Disulfides; D006023:Glycoproteins; D014758:Viral Core Proteins