Lower environmental temperature: effect of long-term exposure on diazepam-induced changes in brain GABA.
Long-term diazepam (DZ) treatment (5 mg/kg, i.p. for 15-30 consecutive days) reduced GABAergic activity in hypothalamus and cerebellum with the alteration of GABA synthesis and its release process. This long-term DZ-induced inhibition in GABAergic activity in hypothalamus and cerebellum was not altered when DZ-treated rats were exposed (2 h/day) to lower environmental temperature (LET; 12 degrees C) for 7-30 consecutive days. Although repeated exposure to LET did not affect the GABA system in cerebellum and hypothalamus, striatal GABAergic activity was significantly enhanced under similar conditions. This LET-induced (repeated exposure) stimulation in striatal GABAergic activity was prevented when rats were treated with DZ along with repeated LET exposure (2 h/day) under long-term conditions.
Biswas
S
S
Department of Biochemistry, University College of Science, University of Calcutta, India.
Mukhopadhyay
S
S
Poddar
M K
MK
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D003080:Cold Temperature; D003342:Corpus Striatum / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D051381:Rats; D013696:Temperature; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D003975:Diazepam