title: Successful stimulation of autologous bone marrow recovery by GM-CSF and IL-3 after an unrelated donor BMT for juvenile CML complicated by graft failure.
abstract: We report the case of a boy with juvenile chronic myeloid leukemia (jCML), who after initial treatment with interferon alpha-2 (IFN) and hydroxyurea underwent bone marrow transplantation (BMT) from a matched unrelated donor complicated by graft failure. Subsequent stimulation of hematopoiesis by GM-CSF and IL-3 promoted autologous recovery. In contrast to the course of disease pre-BMT, the boy is now off any therapy remaining in complete remission more than 500 days after BMT.
authors.affiliation: Dept. of Pediatrics, Univ. of Kiel, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Suttorp
authors.forename: N
authors.initials: N
authors.lastname: Schmitz
authors.forename: E
authors.initials: E
authors.lastname: Prange
authors.forename: A
authors.initials: A
authors.lastname: Ganser
authors.forename: H
authors.initials: H
authors.lastname: Löffler
authors.forename: J
authors.initials: J
authors.lastname: Schaub
mesh_terms: D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D016026:Bone Marrow Transplantation; D002470:Cell Survival; D003131:Combined Modality Therapy; D004357:Drug Synergism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use*; D007223:Infant; D007370:Interferon Type I / Q000627:therapeutic use; D007377:Interleukin-3 / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000601:surgery* / Q000628:therapy; D008297:Male; D012074:Remission Induction
chemical_list: D007155:Immunologic Factors; D007370:Interferon Type I; D007377:Interleukin-3; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006918:Hydroxyurea