In vivo and in vitro degradation of poly(3-hydroxybutyrate) in rat.
The inflammatory activity and biodegradation of poly(3-hydroxybutyrate) were examined. Poly(3-hydroxybutyrate) sheet did not cause any inflammation in the chorioallantoic membrane of the developing egg. The i.v. injection of 14C-labelled poly(3-hydroxybutyrate) granules showed that 86, 2.5 and 2.4% of the total radioactivity administered were distributed in the liver, spleen and lung, respectively, and the radioactivity decreased slowly but steadily in most tissues examined during 2 month. Crude extracts of rat tissues showed that the activity degraded the poly(3-hydroxybutyrate) granules in vitro.
Saito
T
T
Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Tomita
K
K
Juni
K
K
Ooba
K
K
D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D002250:Carbon Radioisotopes; D002823:Chorion / Q000166:cytology; D006863:Hydrogen-Ion Concentration; D006885:Hydroxybutyrates / Q000008:administration & dosage; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D011091:Polyesters / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D013053:Spectrophotometry; D014018:Tissue Distribution; D000094122:Polyhydroxybutyrates
D001672:Biocompatible Materials; D002250:Carbon Radioisotopes; D006885:Hydroxybutyrates; D011091:Polyesters; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates