Importance of chloride in the development of salt-induced angiotensin II hypertension in rats.
This study attempted to evaluate the effect of anion associated with sodium loading on the development of angiotensin II (AII)-induced hypertension in rats. Hypertension was induced by intraperitoneal infusion of AII(125 ng/min) for 12 days via miniosmotic pump (systolic blood pressure on day 12, 143 +/- 3 mm Hg). High dietary intake of sodium chloride significantly augmented the AII-induced hypertension (systolic blood pressure on day 12, 166 +/- 4 mm Hg), but equimolar sodium loading provided as sodium citrate failed to enhance AII hypertension (systolic blood pressure on day 12, 136 +/- 8 mm Hg). Thus, the data suggest that the full expression of salt (NaCl) sensitivity in AII hypertension depends on high dietary intake of both sodium and chloride.
Sato
Y
Y
Fourth Department of Internal Medicine, School of Medicine, University of Tokyo, Japan.
Ogata
E
E
Fujita
T
T
D000804:Angiotensin II / Q000008:administration & dosage*; D000818:Animals; D002712:Chlorides / Q000008:administration & dosage* / Q000494:pharmacology; D002951:Citrates / Q000008:administration & dosage / Q000494:pharmacology; D019343:Citric Acid; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000494:pharmacology
D002712:Chlorides; D002951:Citrates; D000804:Angiotensin II; D019343:Citric Acid; D012965:Sodium Chloride