title: Effects of suramin on phagocytes in vitro.
abstract: In the therapeutically important range (100-200 micrograms/ml), suramin was found to increase the phagocytic activity of human monocytes (measured by the uptake of Saccharomyces cerevisiae and sensitized sheep red blood cells) in vitro. Suramin itself was a chemotactic signal for monocytes and increased the chemiluminescence of neutrophil granulocytes. Suramin seems to act via the ATP-binding P2 receptors of human phagocytes.
authors.affiliation: 3rd Department of Internal Medicine, University Medical School of Debrecen, Hungary.
authors.forename: S
authors.initials: S
authors.lastname: Sipka
authors.forename: K
authors.initials: K
authors.lastname: Dankó
authors.forename: P
authors.initials: P
authors.lastname: Nagy
authors.forename: V
authors.initials: V
authors.lastname: Taskov
authors.forename: L
authors.initials: L
authors.lastname: Dénes
authors.forename: L
authors.initials: L
authors.lastname: Czirják
authors.forename: G
authors.initials: G
authors.lastname: Szegedi
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004912:Erythrocytes; D006801:Humans; D008163:Luminescent Measurements; D009895:Opsonin Proteins; D010586:Phagocytes / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D011983:Receptors, Purinergic / Q000187:drug effects / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D012756:Sheep; D013498:Suramin / Q000494:pharmacology*; D015054:Zymosan / Q000494:pharmacology
chemical_list: D009895:Opsonin Proteins; D011983:Receptors, Purinergic; D013498:Suramin; D000255:Adenosine Triphosphate; D015054:Zymosan