Clinical studies on growth factors in pressure sores: preliminary report.
Agents touted to benefit chronic non-healing wounds will become evermore prevalent. Examples, in addition to those cited, might include epictor (EGF) or platelet derived growth factor (PDGF). Although they may look promising in in vitro and experimental animal studies, they must be tested in humans. The pressure sore is a chronic three dimensional wound which lends itself to study of wound healing agents. It has been used for severe such trials and appears to be an excellent model for the continued study of peptide growth factors.
Robson
M C
MC
University of Texas Medical Branch, Galveston.
Phillips
L G
LG
Heggers
J P
JP
McPherson
M A
MA
Heiner
L S
LS
D004187:Disaccharides / Q000627:therapeutic use; D004311:Double-Blind Method; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use*; D006801:Humans; D003668:Pressure Ulcer / Q000188:drug therapy / Q000628:therapy*; D011994:Recombinant Proteins; D012837:Silver Sulfadiazine / Q000627:therapeutic use; D014945:Wound Healing
C070076:Agent M; D004187:Disaccharides; D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2; D012837:Silver Sulfadiazine