title: Lifestyle determinants of HDL2- and HDL3-cholesterol levels in a hypercholesterolemic male population.
abstract: In this cross-sectional study we investigated the role of lifestyle and other factors in determining serum HDL2- and HDL3-cholesterol levels among 82 dyslipidemic (total cholesterol minus HDL-cholesterol greater than or equal to 5.2 mmol/l) middle-aged participants of the Helsinki Heart Study. Alcohol consumption correlated positively with both subfractions of HDL-cholesterol, while leisure time physical activity had a significant correlation with the HDL3-subfraction only. HDL levels were lower in smokers than in non-smokers but the differences were not statistically significant. Using the multiple linear regression model, alcohol consumption emerged as the only significant factor influencing both HDL cholesterol subfraction levels. Leisure time physical activity had an independent contribution to HDL3-level, but lifestyle variables other than alcohol consumption did not contribute significantly to HDL2-cholesterol level. The model incorporating alcohol consumption, physical activity, smoking and relative body weight explained 13.4% of the variation in HDL2 and 17.5% in HDL3-cholesterol.
authors.affiliation: First Department of Medicine, Helsinki University Central Hospital, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Mänttäri
authors.forename: P
authors.initials: P
authors.lastname: Koskinen
authors.forename: V
authors.initials: V
authors.lastname: Manninen
authors.forename: L
authors.initials: L
authors.lastname: Tenkanen
authors.forename: J K
authors.initials: JK
authors.lastname: Huttunen
mesh_terms: D000428:Alcohol Drinking; D001835:Body Weight; D008076:Cholesterol, HDL / Q000097:blood*; D015444:Exercise; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012907:Smoking; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides