title: A case of progressive encephalomyelitis with rigidity and positive antiglutamic acid decarboxylase antibodies [corrected].
abstract: A 50 year old woman developed progressive encephalomyelitis with rigidity over a three year period. Her CSF contained oligoclonal bands and both her serum and CSF contained antibodies directed against GABA-ergic synapses (antiglutamic acid decarboxylase [corrected] antibodies). These antibodies have recently been described in cases of stiff man syndrome. Both disorders may be part of a clinical spectrum that has an underlying autoimmune basis.
authors.affiliation: Hammersmith Hospital, London, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Burn
authors.forename: J
authors.initials: J
authors.lastname: Ball
authors.forename: A J
authors.initials: AJ
authors.lastname: Lees
authors.forename: P O
authors.initials: PO
authors.lastname: Behan
authors.forename: J A
authors.initials: JA
authors.lastname: Morgan-Hughes
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology; D004679:Encephalomyelitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009127:Muscle Rigidity
chemical_list: D001323:Autoantibodies; D005968:Glutamate Decarboxylase