The regulation of decidual prostaglandin biosynthesis by growth factors, phorbol esters, and calcium.
The production of prostaglandins by decidua may play a significant part in the mechanisms of human parturition. We have evaluated the regulation of prostaglandin production in human decidual cells in monolayer culture. Both epidermal growth factor and transforming growth factor-alpha induced concentration-related increases in decidual prostaglandin production with significant changes occurring at concentrations of 1 to 10 ng/ml. Two active phorbol esters elicited concentration-related increases in decidual prostaglandin production whereas an inactive phorbol analogue was without effect. The calcium ionophores, ionomycin and A-23187, also stimulated prostaglandin production by human decidual cell cultures. Hence prostaglandin production by human decidua is regulated by hormones and agents in a manner similar to that of other cells including amnion and may play a significant part in the mechanism of parturition.
Mitchell
M D
MD
Department of Obstetrics and Gynecology, University of Utah Medical Center, Salt Lake City 84132.
D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D003656:Decidua / Q000187:drug effects / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D015759:Ionomycin / Q000494:pharmacology; D010703:Phorbol Esters / Q000494:pharmacology; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis*; D016211:Transforming Growth Factor alpha / Q000494:pharmacology
D010703:Phorbol Esters; D011453:Prostaglandins; D016211:Transforming Growth Factor alpha; D000001:Calcimycin; D015759:Ionomycin; D004815:Epidermal Growth Factor; D002118:Calcium