Anti-elastin antibodies in rabbits fed an atherogenic diet.
Anti-elastin antibodies which seem to play an important role in atherogenesis were studied in serum of rabbits fed with a cholesterol-rich diet using the dot-immunobinding assay. These antibodies appeared only in rabbits of the experimental group after the sixth week of the experiment and a progressive rise in their titer was observed. The concentration of total serum cholesterol and the elastase-like activity in aorta which were determined additionally showed a statistically significant increase of both analyzed parameters in animals from the experimental group when compared to the controls. Anti-elastin antibodies seem to reflect an increased elastin turnover during the induction of experimental atherosclerosis.
Gmiński
J
J
Department of Biochemistry and Chemistry, Silesian Medical Academy, Katowice, Poland.
Drózdz
M
M
Sułkowski
P
P
D000818:Animals; D001011:Aorta / Q000201:enzymology; D001161:Arteriosclerosis / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D004549:Elastin / Q000276:immunology*; D015151:Immunoblotting; D008297:Male; D010196:Pancreatic Elastase / Q000097:blood; D011817:Rabbits
D001323:Autoantibodies; D004549:Elastin; D002784:Cholesterol; D010196:Pancreatic Elastase