Heterogeneity of renin alleles in outbred Dahl salt-sensitive (Brookhaven) rats.
Selectively outbred Dahl salt-sensitive (DS) and salt-resistant (DR) rats were compared with the inbred Dahl salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats developed from the original Brookhaven stocks by J.P. Rapp. The animals were evaluated for genotype at the renin locus. The inbred strains are uniformly homozygous for their respective alleles, s in SS/Jr and r in SR/Jr. DR rats were also uniformly homozygous for the r renin allele. In DS rats, however, three renin alleles were segregating. In addition to the s and r alleles, a third allele, designated the z allele, was found. The gene frequencies in DS rats were s = 0.690, r = 0.284, and z = 0.026. Continued use of DS and DR rats in most experimental work is inappropriate because of genetic heterogeneity in the DS stock.
O'Dowd
B F
BF
Department of Pharmacology, University of Toronto, Canada.
Rapp
J P
JP
D000483:Alleles; D000818:Animals; D001794:Blood Pressure / Q000235:genetics; D015139:Blotting, Southern; D006579:Heterozygote; D051381:Rats / Q000235:genetics*; D012083:Renin / Q000235:genetics*
D012083:Renin