Effect of intravenous omeprazole on twenty-four-hour intragastric pH in patients with a history of peptic ulcer. Comparison of two four-dosage regimens.
To study the effect of intravenously given omeprazole on the 24-hour gastric secretion, 9 male patients with previously endoscopic proven duodenal ulcer disease were studied. Two four-dose regimens only differing in loading doses were compared. The study showed that 40 mg omeprazole, administered intravenously 4 times a day, is able to keep the gastric pH above 4 in 85% of the 24-hour study period and in 65% of the time pH was above 6. The corresponding values from the baseline period were 10 and 6%. There was no additional effect by a larger loading dose.
Kiilerich
S
S
Medical Department B, Central Hospital, Hillerød, Denmark.
Elsborg
L
L
D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage* / Q000627:therapeutic use
D009853:Omeprazole