title: Significance of pre-S2 protein and its antibody in children with HBV infections.
abstract: Pre-S2 protein and its antibody were detected in 130 children with hepatitis B virus (HBV) infection and 30 with T6 hepatitis B (HB) vaccination. The results showed that pre-S2 was positive in most chronic persistent hepatitis (CPH) and chronic active hepatitis(CAH) patients, while anti-pre-S2 was positive in only 8% (2/92 cases) and 11.5% (3/26 cases) respectively. The positive rate of anti-pre-S2 was 78.9% (15/19 cases) in cases at the convalescent stage of acute hepatitis B, 91.7% (55/60 cases) in cases with T6 HB vaccination and 83.3% (25.30 cases) in naturally acquired anti-HBs children, while pre-S2 was not noted. Anti-pre-S2 was negatively related to ALT and positively to anti-HBs (P less than 0.01). The positive relation of pre-S2 to HBsAg was observed. These results suggest that pre-S2 could be a marker for HBV infection, and anti-pre-S2 may indicate a favourable prognosis of HBV infection. There was no correlation between anti-pre-S2 and pathogenic damages induced by HBV.
authors.affiliation: 302 Hospital of PLA, Beijing.
authors.forename: M X
authors.initials: MX
authors.lastname: Zou
authors.forename: M Y
authors.initials: MY
authors.lastname: Yu
authors.forename: H F
authors.initials: HF
authors.lastname: Zhang
authors.forename: J Q
authors.initials: JQ
authors.lastname: Huang
authors.forename: J M
authors.initials: JM
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000097:blood* / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D011498:Protein Precursors / Q000097:blood* / Q000276:immunology; D014759:Viral Envelope Proteins / Q000097:blood*
chemical_list: D000914:Antibodies, Viral; D015415:Biomarkers; D006514:Hepatitis B Surface Antigens; D011498:Protein Precursors; D014759:Viral Envelope Proteins; C050807:presurface protein 2, hepatitis B surface antigen