Comparison of changes in uptake and mucosal processing of iron in short and long-term iron depletion.
Thirty minutes following an intragastric dose of [59]Fe, rats subjected to short-term and long-term iron depletion showed a similar increase in [59]Fe in plasma and a similar decrease in the retention of [59]Fe in mucosal cytosol compared to controls. With both low-iron groups, a two-fold increase in [59]Fe uptake by brush-border membrane vesicles and a six-fold reduction in the [59]Fe incorporated into the ferritin of the mucosal cytosol were observed. These studies indicate that short-term exposure to a low-iron diet triggers changes in both the uptake of iron by the brush-border membrane and the processing of iron within the mucosal cell prior to major changes in body iron status.
Topham
R W
RW
Department of Chemistry, University of Richmond, VA 23173.
Eads
C E
CE
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D005293:Ferritins / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D007501:Iron / Q000097:blood / Q000378:metabolism*; D000090463:Iron Deficiencies; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D008871:Microvilli / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D014168:Transferrin / Q000378:metabolism; D014617:Vacuoles / Q000378:metabolism
D014168:Transferrin; D005293:Ferritins; D007501:Iron