[Effect of low molecular weight regulators on the biosynthesis of rifamycin B by Amycolatopsis mediterranei strains].
Formation of differentiation regulators of the A-factor group in representatives of Nocardia and Nocardia-like actinomyces: N. asteroides, N. brasiliensis, Amycolatopsis mediterranei and "Streptomyces listeri" was observed. The effect of the regulators of different nature (barbital, A-factor and B-factor) on biosynthesis of rifamycin B by A. mediterranei strains was studied. It was shown that the A-factor stimulated rifamycin B production in the adifferentiated low active variant isolated from a natural population of the active strain VNIIA 1713 of the rifamycin B-producing culture. B-Factor insignificantly inhibited biosynthesis of rifamycin B in the studied strains of A. mediterranei.
Bushueva
O A
OA
Efremenkova
O V
OV
Gorin
S E
SE
Bartoshevich
Iu E
IuE
D000192:Actinomycetales / Q000378:metabolism*; D008970:Molecular Weight; D009615:Nocardia / Q000378:metabolism; D012294:Rifamycins / Q000096:biosynthesis*
D012294:Rifamycins; C033974:rifamycin B
Vliianie nizkomolekuliarnykh reguliatorov na biosintez rifamitsina B shtammami Amycolatopsis mediterranei.