title: Chemiluminescent 10-methyl-acridinium-9-(N-sulphonylcarboxamide) salts. Synthesis and kinetics of light emission.
abstract: 10-Methyl-acridinium-9-(N-sulphonylcarboxamide) salts are prepared via acylation of sulphonamides with acridine-9-carboxylic acid chloride and subsequent N-alkylation with methyl triflate. Substituents on the sulphonamide component were varied to show the effect of steric and electronic factors on the kinetics of light output. The lifetime of the chemiluminescence light output ranged from 1 to 50 seconds for the 15 compounds reported. The long-term stability of the new compounds was superior to the phenyl ester counterparts.
authors.affiliation: Abbott Laboratories, Diagnostics Division, Abbott Park, IL 60064.
authors.forename: P G
authors.initials: PG
authors.lastname: Mattingly
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry; D004355:Drug Stability; D008163:Luminescent Measurements; D015394:Molecular Structure; D012995:Solubility; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000166:Acridines; D013450:Sulfones; C522609:acridine-9-carboxylic acid