Radioprotective effect of dextran sulphate and aerogenic hypoxia on intestinal crypt stem cells in mice.
A single intraperitoneal injection of dextran sulphate given 6 h before irradiation produced higher numbers of microcolonies of intestinal crypt stem cells in whole-body irradiated mice than injection of saline in control mice. If dextran sulphate and hypoxia are combined, the radioprotective effect of hypoxia on intestinal crypt stem cells depends on the time interval between irradiation and administration of dextran sulphate.
Vacek
A
A
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Konoplyanikova
O A
OA
Konoplyanikov
A G
AG
Bartonícková
A
A
Rotkovská
D
D
D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology*; D016264:Dextran Sulfate / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007413:Intestinal Mucosa / Q000166:cytology* / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013234:Stem Cells / Q000187:drug effects / Q000528:radiation effects*; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D016264:Dextran Sulfate