title: Suppression of Con A induced lymphocyte transformation by sera from filarial patients with clinical manifestations.
abstract: Reduced lymphocyte transformation to Wuchereria bancrofti microfilariae excretory-secretory antigen and Con A were observed in clinical filarial patients. Pre-incubation of normal human peripheral blood mononuclear cells with sera from filarial patients with clinical manifestations such as hydrocele and elephantiasis suppressed Con A induced responses. Effect of fractionated clinical filarial serum on Con A induced lymphocyte transformation showed that the inhibitory activity was associated with high molecular weight serum fraction.
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Wardba, India.
authors.forename: G B
authors.initials: GB
authors.lastname: Prasad
authors.forename: I
authors.initials: I
authors.lastname: Kharat
authors.forename: B C
authors.initials: BC
authors.lastname: Harinath
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000276:immunology; D004605:Elephantiasis, Filarial / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D014958:Wuchereria bancrofti / Q000276:immunology
chemical_list: D003208:Concanavalin A