[The membranotropic and neurotropic properties of remantadine and deitiforin in experimental models].
The specific neurotropic action of rimantadine was demonstrated in mollusk neuron experiments. No specific neurotropic activity of dejtiphorin was found. In combined application, the latter blocked the neurotropic effect of rimantadine. In experiments in white mice and rats, high doses of both drugs decreased the emotional and motor activity of the animals. After the use of the combination of the two drugs the activity of the animals did not differ significantly from that in the controls. The antiviral effect of each drug alone and of combination thereof was similar.
Lobanova
E A
EA
Iniushin
M Iu
MIu
Andreev
N Iu
NIu
Kiselev
O I
OI
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D002642:Chick Embryo; D006372:Helix, Snails; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects*; D009930:Organic Chemicals; D051381:Rats; D011919:Rats, Inbred Strains; D012299:Rimantadine / Q000494:pharmacology*
D000998:Antiviral Agents; D009930:Organic Chemicals; D012299:Rimantadine; C060204:deitiforin
Izuchenie mebranotropnykh i neĭrotropnykh svoĭstv remantadina i deĭtiforina na éksperimental'nykh modeliakh.