Recent studies on antimalarial efficacy of piperaquine and hydroxypiperaquine.
Piperaquine and hydroxypiperaquine seem to be successful candidates of antimalarial drugs in China. Their antimalarial efficacy, experimental resistance, combination, mode of antimalarial action and clinical trials are described briefly.
Chen
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Laboratory for Antimalarial Drug Research, Second Military Medical University, Shanghai.
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects; D010963:Plasmodium falciparum; D011804:Quinolines / Q000494:pharmacology* / Q000627:therapeutic use; D010879:Piperazines
D000962:Antimalarials; D011804:Quinolines; C030684:hydroxypiperaquine; C034759:piperaquine; D010879:Piperazines