The effects of the combination of phentolamine and vasopressin on hepatic and systemic hemodynamics in cirrhotic portal hypertensive dog model.
The experimental study was aimed at elucidating the effects of phentolamine and vasopressin used separately or in combination on hepatic and systemic hemodynamics in cirrhotic portal hypertensive dogs. The results showed that either of the two drugs used separately could lead to reduction in portal venous pressure and could also influence systemic hemodynamics or lower hepatic blood flow. When phentolamine in combination with vasopressin was administered, no side-effect could be found on hepatic and systemic hemodynamics, suggesting that the drugs used in combination could efficaciously decrease portal hypertension and counteract their respective side-effect. This combination therapy will be useful in treating bleeding from esophageal variceal rupture in cirrhotic patients with portal hypertension.
Dan
Z L
ZL
Institute of Liver Diseases, Tongji Hospital, Tongji Medical University, Wuhan.
Zhao
Q
Q
Li
S B
SB
D000818:Animals; D004285:Dogs; D004359:Drug Therapy, Combination; D004932:Esophageal and Gastric Varices / Q000188:drug therapy; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006975:Hypertension, Portal / Q000188:drug therapy* / Q000503:physiopathology; D008102:Liver Circulation / Q000187:drug effects*; D008106:Liver Cirrhosis, Experimental / Q000150:complications*; D008297:Male; D010646:Phentolamine / Q000008:administration & dosage* / Q000494:pharmacology; D014667:Vasopressins / Q000008:administration & dosage* / Q000494:pharmacology
D014667:Vasopressins; D010646:Phentolamine