title: Mechanisms of renin release from juxtaglomerular cells.
abstract: In microdissected, nonperfused afferent arterioles changes in intravascular pressure did not affect renin secretion. On the contrary, renin release from isolated afferent arterioles perfused in a free-flow system has been reported to be sensitive to simultaneous changes in luminal pressure and flow. Hence local blood flow may be involved in the baroreceptor control of renin release. If flow is sensed, the sensor is likely to be located near the endothelial cell layer, where ion channels have been shown to be influenced by variations in shear stress.
authors.affiliation: Institute of Experimental Medicine, University of Copenhagen, Denmark.
authors.forename: O
authors.initials: O
authors.lastname: Skøtt
authors.forename: M
authors.initials: M
authors.lastname: Salomonsson
authors.forename: A E
authors.initials: AE
authors.lastname: Persson
authors.forename: B L
authors.initials: BL
authors.lastname: Jensen
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology; D005942:Gluconates / Q000494:pharmacology; D066298:In Vitro Techniques; D007606:Juxtaglomerular Apparatus / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D012083:Renin / Q000378:metabolism*; D013395:Sucrose / Q000494:pharmacology
chemical_list: D002712:Chlorides; D005942:Gluconates; D013395:Sucrose; D012083:Renin; C030691:gluconic acid; D002118:Calcium