title: Erythrocyte and platelet fatty acids in retinitis pigmentosa.
abstract: The fatty acid composition and the glutathione-peroxidase activity (GSH-Px) of erythrocytes and platelets, the production of malondialdehyde (MDA) by platelets and the activity of the main systems of transmembrane cation transport in erythrocyte have been studied in 12 patients (5 males and 7 females) affected by retinitis pigmentosa (RP). A remarkable increase of saturated fatty acids (SFA), particularly of stearic acid (C18:0), has been noted in these patients. The reduced unsaturated/saturated fatty acids ratio (PUFA/SFA) observed in both erythrocytes and platelets and the decrease of arachidonic acid in platelets may depend by an active peroxidation process as documented by the increase of MDA. Platelet glutathione-peroxidase (PTL-GSH-PX) and plasma retinol were in the normal range, whereas erythrocyte glutathione-peroxidase (E-GSH-PX), MDA and plasma alfa-toco-pherol were increased in patients with RP. The activities of Na(+)-K+ pump, cotransport and Na(+)-Li+ countertransport were normal in RP erythrocytes.
authors.affiliation: Istituto di Patologia Medica, Università di Verona, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Stanzial
authors.forename: L
authors.initials: L
authors.lastname: Bonomi
authors.forename: C
authors.initials: C
authors.lastname: Cobbe
authors.forename: O
authors.initials: O
authors.lastname: Olivieri
authors.forename: D
authors.initials: D
authors.lastname: Girelli
authors.forename: M T
authors.initials: MT
authors.lastname: Trevisan
authors.forename: A
authors.initials: A
authors.lastname: Bassi
authors.forename: S
authors.initials: S
authors.lastname: Ferrari
authors.forename: R
authors.initials: R
authors.lastname: Corrocher
mesh_terms: D000328:Adult; D001692:Biological Transport; D001792:Blood Platelets / Q000737:chemistry* / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000378:metabolism; D004912:Erythrocytes / Q000737:chemistry* / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D012174:Retinitis Pigmentosa / Q000378:metabolism*; D012964:Sodium / Q000493:pharmacokinetics; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D005227:Fatty Acids; D014801:Vitamin A; D014810:Vitamin E; D008315:Malondialdehyde; D012964:Sodium; D005979:Glutathione Peroxidase