Reversible tricuspid regurgitation in a patient undergoing treatment for acute leukemia.
A 52-year-old female patient treated for acute lymphoblastic leukemia with combination chemotherapy (cyclophosphamide, vincristine, adriamycin and prednisone), broad spectrum antibiotics and amphotericin via a Hickman catheter placed in the superior vena cava, developed echocardiographically confirmed tricuspid regurgitation. A second admission four months later showed only mild tricuspid regurgitation. The authors conclude that the amphotericin given via the central line caused valvulitis of the tricuspid valve.
Marshall
T M
TM
Department of Medicine, Vancouver General Hospital, British Columbia.
Tirgan
M H
MH
Pollick
C
C
Shepherd
J D
JD
D000666:Amphotericin B / Q000009:adverse effects* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002405:Catheterization, Central Venous; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D014262:Tricuspid Valve Insufficiency / Q000139:chemically induced* / Q000000981:diagnostic imaging; D014683:Vena Cava, Superior
D000900:Anti-Bacterial Agents; D000666:Amphotericin B