title: Characterization of sodium-selective optode membranes based on neutral ionophores and assay of sodium in plasma.
abstract: Plasticized poly(vinyl chloride) membranes that incorporate a highly lipophilic sodium-selective neutral ionophore (ETH 4120) and novel H(+)-selective chromo-ionophores, lipophilic isologs of Nile Blue, are used in the competitive binding of Na+ and H+ for a reversible, optical determination of sodium activities in buffered solutions at different selected pH values. These optode membranes are used to assay total sodium concentrations in pH-buffered human blood plasma.
authors.affiliation: Swiss Federal Institute of Technology (ETH), Department of Organic Chemistry, Zürich, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Seiler
authors.forename: K
authors.initials: K
authors.lastname: Wang
authors.forename: E
authors.initials: E
authors.lastname: Bakker
authors.forename: W E
authors.initials: WE
authors.lastname: Morf
authors.forename: B
authors.initials: B
authors.lastname: Rusterholz
authors.forename: U E
authors.initials: UE
authors.lastname: Spichiger
authors.forename: W
authors.initials: W
authors.lastname: Simon
mesh_terms: D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007476:Ionophores / Q000737:chemistry*; D008567:Membranes, Artificial; D011143:Polyvinyl Chloride; D012964:Sodium / Q000097:blood*; D013379:Substrate Specificity
chemical_list: D007476:Ionophores; D008567:Membranes, Artificial; D011143:Polyvinyl Chloride; D012964:Sodium