title: Lung mechanics and airway pressure transmission in infants after open heart surgery.
abstract: To evaluate the effects of positive airway pressure on lung mechanics and airway pressure transmission into the intrathoracic space, airway and intrathoracic pressure were recorded during stepwise lung inflation in 17 infants undergoing open heart surgery during the first year of life. Eleven of the 17 patients had cuffed tracheal tubes allowing calculation of lung and chest wall compliance. In 7 of these 11 patients, lung inflation to 2.5 ml/kg above functional residual capacity produced an improvement in initially low lung compliance. This volume increment required elevation of airway pressure by 4-11 cm H2O above ambient. Further lung inflation to 10 ml/kg did not effect an improvement in lung mechanics. In the remaining patients, initial lung compliance was high and remained unchanged throughout the range of lung inflation. Transmission of pressure into the intrathoracic space averaged 47 +/- 9% (mean +/- SD) and ranged from 33% to 61% when airway pressure was 10-15 cm H2O. The results indicate that the use of moderately elevated airway pressure is required to optimize lung distensibility in most infants immediately after open heart surgery. When evaluating circulatory effects of elevated airway pressure, assumption of a 50% pressure transmission is appropriate for clinical purposes. However, the observed wide range of pressure transmission warrants careful hemodynamic monitoring during continuous positive pressure breathing.
authors.affiliation: Department of Anesthesiology, University of South Florida College of Medicine, Tampa.
authors.forename: J
authors.initials: J
authors.lastname: Räsänen
authors.forename: K
authors.initials: K
authors.lastname: Peltola
authors.forename: M
authors.initials: M
authors.lastname: Leijala
mesh_terms: D005260:Female; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007223:Infant; D008168:Lung / Q000503:physiopathology; D008170:Lung Compliance / Q000502:physiology*; D008176:Lung Volume Measurements; D008297:Male; D011175:Positive-Pressure Respiration; D011183:Postoperative Complications / Q000503:physiopathology*