Selective anorexigenic effects of corticotropin releasing hormone in the rhesus monkey.
1. Rhesus monkeys were equipped with a novel intracerebroventricular (i.c.v.) cannula system and trained to respond under operant schedules of food presentation or termination of stimuli associated with the delivery of shock (escape). 2. CRH decreased food-maintained behavior in a dose-related manner over the range of (0.3-10 micrograms/kg) but did not affect escape responding, demonstrating a selective effect on food-maintained responding. 3. This selective effect was related to the tendency for responding to stop after delivery of a food pellet when higher doses of CRH were given, consistent with the notion that a conditioned aversion to food was established in the presence of CRH. 4. This may suggest that in hyperaroused clinical states such as depression and anorexia nervosa, focus is shifted away from appetitive tasks as a result of increased levels of CRH.
Glowa
J R
JR
Clinical Neuroendocrinology Branch, NIMH, NIH, Bethesda, MD.
Bacher
J D
JD
Herkenham
M
M
Gold
P W
PW
D000818:Animals; D001067:Appetite Depressants; D001522:Behavior, Animal / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005502:Food; D007276:Injections, Intraventricular; D008253:Macaca mulatta; D008297:Male; D012055:Reinforcement Schedule
D001067:Appetite Depressants; D003346:Corticotropin-Releasing Hormone