Effect of a synthetic adjuvant for inducing anti-tumour immunity.
An acylated derivative of muramyl dipeptide (MDP), 6-O-(2-tetradecyl-hexadecanoyl)-muramyl-dipeptide (B30-MDP) is a strong adjuvant effective in inducing cell-mediated immunity. We used B30-MDP as an adjuvant for induction of anti-tumour immunity. Guinea-pigs which were injected repeatedly with a mixture of X-ray-treated leukaemic cells and B30-MDP dissolved in phosphate buffered saline resisted a challenge of leukaemia cells and showed no sign of leukocytosis. The immunity induced was tumour-specific and retained for more than 100 days. These results suggest that B30-MDP is useful as a simple but potent immunotherapeutic tool.
Kataoka
T
T
Department of Cellular Immunology, National Institute of Health, Tokyo, Japan.
Kinomoto
M
M
Takegawa
M
M
Tokunaga
T
T
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage*; D005260:Female; D006168:Guinea Pigs; D015448:Leukemia, B-Cell / Q000276:immunology / Q000517:prevention & control; D008297:Male; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000517:prevention & control; D014612:Vaccines / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm; D014612:Vaccines; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C044706:B 30-muramyl dipeptide