title: Local cerebral glucose utilization in the brain of old, learning impaired rats.
abstract: The local cerebral glucose utilization (LCGU) was measured in 63 different cortical areas and nuclei of the telencephalon, diencephalon and rhombencephalon of young adult (3 to 4-month-old) rats and of 27-month-old Wistar rats, in which learning impairments had been proven by a water maze test. The LCGU was determined by [14C]2-deoxyglucose autoradiography. In the old rats the mean LCGU of all brain regions was significantly reduced by about 10% compared with the young control group; the mean LCGU was 74.2 mumol glucose/(100 g x min) in the young and 66.7 in the old rats. Different degrees of LCGU decrease were found in the different regions. Most of the brain regions with significantly reduced LCGU values in the aged, learning impaired rats were associated with auditory and visual functions, the dopaminergic system, and structures known to be involved in learning and memory processes. Therefore, the regional pattern of LCGU reduction found in the aged, learning impaired rats did not resemble any known pattern found after lesions of a single transmitter system or systemic administration of transmitter agonists or antagonists.
authors.affiliation: Anatomisches Institut, Universität Würzburg, Federal Republic of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Wree
authors.forename: C
authors.initials: C
authors.lastname: Kaever
authors.forename: B
authors.initials: B
authors.lastname: Birgel
authors.forename: A
authors.initials: A
authors.lastname: Schleicher
authors.forename: E
authors.initials: E
authors.lastname: Horvath
authors.forename: K
authors.initials: K
authors.lastname: Zilles
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002250:Carbon Radioisotopes; D003847:Deoxyglucose; D004734:Energy Metabolism; D007091:Image Processing, Computer-Assisted; D007859:Learning Disabilities / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002250:Carbon Radioisotopes; D003847:Deoxyglucose