Some approaches to prevention of endogenous formation of N-nitrosamines in humans.
In a series of experiments on formation of N-nitrosamines from precursors in the gastric juice, we investigated individual nitrosation capacity and the influence of inhibitors on this process. In the presence of a molar ratio of 2:1 ascorbic acid:NaNO2, we found increased nitrosamine formation in 34% of gastric juice samples. Ferulic acid and caffeic acid generally suppressed nitrosation at high concentrations and stimulated it at low concentrations. The concentration at which the transition from a stimulating to an inhibitory effect occurs depends on individual differences in the gastric juice.
Dikun
P P
PP
N.N. Petrov Research Institute of Oncology of the USSR, Ministry of Health, Leningrad.
Ermilov
V B
VB
Shendrikova
I A
IA
D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D004123:Dimethylamines / Q000378:metabolism; D004128:Dimethylnitrosamine / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D009602:Nitrosamines / Q000378:metabolism*
D000975:Antioxidants; D004123:Dimethylamines; D009602:Nitrosamines; C034516:dimethylamine; D004128:Dimethylnitrosamine; D001205:Ascorbic Acid