title: Epidemiological study of precursor lesions of oesophageal cancer among young persons in Huixian, China.
abstract: A total of 538 subjects (354 males, 184 females) were investigated in a high-risk area for oesophageal cancer in China to provide large-scale data on the prevalence of chronic oesophagitis among persons below 25 years of age. The survey included an oesophagoscopy with guided biopsies and cytology, a physical examination, an interview and collection of a 10-ml blood sample and overnight urine. Histologically confirmed oesophagitis was found in 43.5% of male and 35.6% of female subjects. Mild and moderate oesophagitis was associated positively with consumption of burning hot beverages, family history of oesophageal cancer, frequent consumption of cottonseed oil, cigarette smoking, a clinical diagnosis of oral leukoplakia and seborrhoeic dermatitis; negative associations were seen with frequent consumption of fresh fruit, meat and eggs. A significantly higher level of urinary nitrate was found in the diseased group, but no difference was seen with regard to any of the N-nitrosamino acids measured.
authors.affiliation: German Cancer Research Center, Institute of Epidemiology and Biometry, Heidelberg.
authors.forename: J
authors.initials: J
authors.lastname: Chang-Claude
authors.forename: J
authors.initials: J
authors.lastname: Wahrendorf
authors.forename: S L
authors.initials: SL
authors.lastname: Qiu
authors.forename: G R
authors.initials: GR
authors.lastname: Yang
authors.forename: N
authors.initials: N
authors.lastname: Muñoz
authors.forename: M
authors.initials: M
authors.lastname: Crespi
authors.forename: R
authors.initials: R
authors.lastname: Raedsch
authors.forename: D I
authors.initials: DI
authors.lastname: Thurnham
authors.forename: P
authors.initials: P
authors.lastname: Correa
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D002908:Chronic Disease; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D004941:Esophagitis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D009603:Nitroso Compounds / Q000652:urine; D011230:Precancerous Conditions / Q000453:epidemiology*; D012307:Risk Factors; D013844:Thiazoles / Q000652:urine; D053778:Thiazolidines
chemical_list: D009603:Nitroso Compounds; D013844:Thiazoles; D053778:Thiazolidines; C040387:N-nitrosothiazolidine-4-carboxylic acid