[Immunoglobulin antibodies to lysosomal enzymes as a means of proteolysis inhibition in severe blood loss].
Experiments were conducted on rats with massive prolonged blood loss to study the effect of immunoglobulins to lysosomal enzymes in combination with isotonic sodium chloride solution on the values of hemodynamics, oxygen regimen, and acid-base balance in the organism. Administration of antibodies to the lysosomal enzymes with an infusion medium leads to a decrease of cathepsin D activity to the initial level. Most probably, diminution of proteolysis is conducive to improvement of circulation. Inhibition of protease activity improves the permeability of vessels and thus facilitates an increase of the volume of circulating plasma, which may be judged from the authentic decrease of the hematocrit and hemoglobin. The oxygen budget and the acid-base balance in the organism are restored more fully. The use of immunoglobulins to lysosomal enzymes prolongs the animals' life.
Remizova
M I
MI
Pecherskaia
G V
GV
D000818:Animals; D010450:Endopeptidases / Q000276:immunology*; D005260:Female; D007116:Immunization, Passive / Q000379:methods*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051381:Rats; D012771:Shock, Hemorrhagic / Q000201:enzymology / Q000628:therapy*
D010450:Endopeptidases
Immunoglobuliny k fermentam lizosom kak sredstvo ingibirovaniia proteoliza pri tiazheloĭ krovopotere.