title: Metabolism of T-2 toxin by rat brain homogenate.
abstract: HT-2 toxin was the sole metabolite formed when T-2 toxin was treated with homogenate from brain without its blood content. Homogenate from brain with its full blood content produced--besides HT-2 toxin--T-2 triol, neosolaniol, 4-deacetylneosolaniol and T-2 tetraol, i.e. the same metabolites formed by incubation of T-2 toxin with whole rat blood.
authors.affiliation: Department of Natural Products, School of Pharmacy, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: B
authors.initials: B
authors.lastname: Yagen
authors.forename: F
authors.initials: F
authors.lastname: Bergmann
authors.forename: S
authors.initials: S
authors.lastname: Barel
authors.forename: A
authors.initials: A
authors.lastname: Sintov
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D006867:Hydrolases / Q000378:metabolism; D006868:Hydrolysis; D008297:Male; D051381:Rats; D013379:Substrate Specificity; D013605:T-2 Toxin / Q000378:metabolism* / Q000031:analogs & derivatives; D014255:Trichothecenes / Q000378:metabolism
chemical_list: D014255:Trichothecenes; C038854:scirpentriol; C016009:neosolaniol; C070178:4-deacetylneosolaniol; D006867:Hydrolases; D013605:T-2 Toxin; C012351:HT-2 toxin