title: Factors determining ventricular fibrillation after induced cardiac arrest.
abstract: Ventricular fibrillation following release of the aortic cross clamp is not uncommon. In 38 patients undergoing aortic valve replacement we investigated if this disturbance of rhythm is due to perioperative myocardial ischemia or due to deterioration of myocardial function prior to surgery. In all cases hypothermic cardioplegic arrest (Bretschneider) was used. The mean duration of ischemia was 49.39 +/- 10.46 minutes. After release of the aortic cross clamp in 17 of 38 patients ventricular fibrillation occurred. To find out which factors are responsible for the occurrence of ventricular fibrillation we performed a statistical analysis. Thereby we found out that the occurrence of ventricular fibrillation did not correlate with ischemia, the maximal level of myocardium-bound creatine kinase, the NYHA stage, or the left ventricular end diastolic pressure. The left-ventricular concentration of noradrenaline determined just before release of the aortic cross clamp showed a significant negative correlation with the occurrence of ventricular fibrillation. From our results we conclude that ischemic injury was not the determining factor for the occurrence of ventricular fibrillation in our study. We suggest that the significant correlation with reduced myocardial noradrenaline content demonstrates that myocardial deterioration prior to surgery is the determining factor for the occurrence of ventricular fibrillation.
authors.affiliation: Department of Cardiovascular Surgery, Justus-Leibig-University, Giessen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Görlach
authors.forename: T
authors.initials: T
authors.lastname: Podzuweit
authors.forename: B
authors.initials: B
authors.lastname: Borsutzky
authors.forename: E
authors.initials: E
authors.lastname: Lohmann
authors.forename: F
authors.initials: F
authors.lastname: Dapper
mesh_terms: D000704:Analysis of Variance; D001022:Aortic Valve Insufficiency / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006324:Heart Arrest, Induced / Q000009:adverse effects*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D014693:Ventricular Fibrillation / Q000209:etiology*
chemical_list: D009638:Norepinephrine