Lack of modification by naturally occurring antioxidants of 3,2'-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis.
The modifying effects of 6 naturally occurring antioxidants on 3,2'-dimethyl-4-aminobiphenyl (DMAB)-initiated rat prostate carcinogenesis were investigated in male F344 rats. Animals were pretreated with DMAB in a 20-week initiation protocol and then administered basal diet containing 0.8% catechol, 0.8% resorcinol, 0.8% hydroquinone, 2 ppm selenium, 2% gamma-orysanol or 1% alpha-tocopherol for 40 weeks. The experiment was terminated at week 60 for histopathological assessment of lesion development. Atypical hyperplasias and carcinomas of the prostate were observed in the ventral lobe in all groups treated with DMAB. However, the incidences of these lesions were not significantly different between carcinogen control and antioxidant-treated groups. There were also no significant increases or decreases in the incidences of tumors in any other organs.
Nakamura
A
A
First Department of Pathology, Nagoya City University Medical School, Japan.
Shirai
T
T
Takahashi
S
S
Ogawa
K
K
Hirose
M
M
Ito
N
N
D000611:Aminobiphenyl Compounds / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002273:Carcinogens; D002396:Catechols / Q000494:pharmacology; D006873:Hydroquinones / Q000494:pharmacology; D006965:Hyperplasia / Q000139:chemically induced; D000960:Hypolipidemic Agents / Q000494:pharmacology; D007414:Intestinal Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D010190:Pancreatic Neoplasms / Q000139:chemically induced; D010666:Phenylpropionates / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D012118:Resorcinols / Q000494:pharmacology; D012643:Selenium / Q000494:pharmacology; D013736:Testicular Neoplasms / Q000139:chemically induced; D014810:Vitamin E / Q000494:pharmacology
D000611:Aminobiphenyl Compounds; D000975:Antioxidants; D002273:Carcinogens; D002396:Catechols; D006873:Hydroquinones; D000960:Hypolipidemic Agents; D010666:Phenylpropionates; D012118:Resorcinols; C001042:2',3-dimethyl-4-aminobiphenyl; D014810:Vitamin E; D012643:Selenium; C034221:catechol; C013172:gamma-oryzanol; C031927:hydroquinone; C031389:resorcinol