Brain protein synthesis in rabbits following low level aluminium exposure.
1. Infant rabbits received s.c.injections 3 times weekly of low doses of aluminium (A1) maltolate (0.5-1.5 mg Al/kg body wt) or aluminium lactate (8 mg Al/kg body wt) from 5 or 10 days of age to 14 or 22 days of age. 2. Brain was used to provide a cell-free protein synthesizing system and this system exhibited increased activity in preparations from Al-exposed infants. The mRNA fraction obtained from the brain polysomal RNA also was more active following Al exposure. 3. The synthesis of immunoprecipitable calmodulin was significantly elevated.
Nicholls
D M
DM
Department of Biology, York University, Ontario, Canada.
Speares
G M
GM
Miller
A C
AC
Math
J
J
Del Bianco
G
G
D000535:Aluminum / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002147:Calmodulin / Q000096:biosynthesis; D002474:Cell-Free System; D007773:Lactates / Q000494:pharmacology; D019344:Lactic Acid; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009942:Organometallic Compounds / Q000494:pharmacology; D011132:Polyribosomes / Q000378:metabolism; D011753:Pyrones / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D011817:Rabbits
D002147:Calmodulin; D007773:Lactates; D009419:Nerve Tissue Proteins; D009942:Organometallic Compounds; D011753:Pyrones; D012333:RNA, Messenger; C067527:aluminum maltolate; D019344:Lactic Acid; D000535:Aluminum