title: [Usefulness of 123I-IMP SPECT in patients with epilepsy].
abstract: N-isopropyl-p-[123I]iodoamphetamine(123I-IMP)SPECT and electroencephalography (EEG) were evaluated in 21 epileptic patients at interictal stage. The findings of 123I-IMP were compared with those of clinical symptoms and EEG. In 11 cases (85%) of 13 patients with the partial seizure, and 6 cases (75%) of 8 patients with the generalized seizure had focal decreased perfusion of 123I-IMP. The mean number of focal decreased perfusion areas were 3.2 locations 1 case. There were no cases that was observed focal increased perfusion. Focal decreased perfusion area of 123I-IMP SPECT findings agreed with the focuses those were inferred from clinical findings in 8 cases (62%) out of 13 patients with the partial seizure, did not agree in 3 cases (23%) and did not detected in 2 cases (15%). Overall abnormality of 123I-IMP SPECT was observed in 17 cases (81%) out of 21 patients, on the other hand abnormality of EEG was observed in 12 cases (57%). 123I-IMP SPECT may provide useful information for evaluating foci in patients with epilepsy.
authors.affiliation: Department of Radiology, Miyazaki Medical College.
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Hoshi
authors.forename: T
authors.initials: T
authors.lastname: Ohnishi
authors.forename: S
authors.initials: S
authors.lastname: Nagamachi
authors.forename: S
authors.initials: S
authors.lastname: Jinnouchi
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine