title: [The pharmacokinetic and pharmacodynamic characteristics of diazepam in different populations of rats].
abstract: Significant differences in diazepam pharmacokinetics in different populations of rats both within one family and within one species were revealed. A high degree of correlation between the pharmacokinetic parameters and pharmacodynamic indices indicates that the myorelaxant effect is in a direct dependence on diazepam concentration in the rat organism.
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: A A
authors.initials: AA
authors.lastname: Dvorianikov
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: I V
authors.initials: IV
authors.lastname: Savchenko
mesh_terms: D000818:Animals; D003975:Diazepam / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D051381:Rats / Q000378:metabolism*; D011919:Rats, Inbred Strains; D016205:Sigmodontinae; D013045:Species Specificity; D013997:Time Factors
chemical_list: D003975:Diazepam
vernacular_title: Izuchenie osobennosteĭ farmakokinetiki i farmakodinamiki diazepama u krys razlichnykh populiatsiĭ.