title: [Vitamin K1 and C metabolism in uremia during hemodialysis].
abstract: Plasma concentrations of vitamin K1, ascorbic acid and its derivatives were investigated in uremic patients during a session of systemic hemodialysis at the dialyzers input, output and in dialyzing solution. The data showed practically unchanged clearances of vitamin C and diketogulonic acid during the session of hemodialysis. In the course of its passage through the dialyzer, plasma ascorbic acid was partially oxidized to dehydroascorbic acid, partially it converted to a dialysate, partially it returned to the human body. Plasma level of vitamin K1 in uremic patients was 1.8 times lower than that in the healthy; 24-hour its excretion in uremic patients and in the healthy was similar. It is supposed that the vitamin K1 decrease correlates with lipoid changes in uremia. During a session of hemodialysis no significant vitamin K1 losses were revealed.
authors.forename: V V
authors.initials: VV
authors.lastname: Bakaev
authors.forename: V F
authors.initials: VF
authors.lastname: Khomenko
mesh_terms: D001205:Ascorbic Acid / Q000378:metabolism*; D002908:Chronic Disease; D005921:Glomerulonephritis / Q000150:complications / Q000378:metabolism / Q000628:therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D011704:Pyelonephritis / Q000150:complications / Q000378:metabolism / Q000628:therapy; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism* / Q000628:therapy; D010837:Vitamin K 1 / Q000378:metabolism*
chemical_list: D010837:Vitamin K 1; D001205:Ascorbic Acid
vernacular_title: Issledovanie metabolizma vitaminov K1 i C pri uremii v protsesse gemodializa.