title: Fine needle aspiration cytodiagnosis as a pre-requisite for primary medical treatment of breast cancer.
abstract: The accurate non-surgical diagnosis of breast lumps allows assessment of breast cancer patients for conservation or neoadjuvant primary treatment before surgical intervention. We have analysed the accuracy of clinical assessment, fine needle aspiration cytology (FNAC), and mammography in over 868 women seen in a symptomatic breast clinic. Clinical examination by an experienced breast physician, together with FNAC, detected over 99% of the cancers with a 12% false positive rate. A cytological diagnosis of definite carcinoma was obtained in 69% of women with breast cancer with no false positive result from the women with benign conditions producing a 100% positive predictive value. These results indicate that it would be acceptable to give pre-surgical systemic endocrine or chemotherapy to women with positive cytology which is therefore a prerequisite for a neoadjuvant therapy programme.
authors.affiliation: Department of Cytopathology, Royal Marsden Hospital, Sutton, Surrey.
authors.forename: T J
authors.initials: TJ
authors.lastname: Powles
authors.forename: P A
authors.initials: PA
authors.lastname: Trott
authors.forename: G
authors.initials: G
authors.lastname: Cherryman
authors.forename: S
authors.initials: S
authors.lastname: Clarke
authors.forename: S
authors.initials: S
authors.lastname: Ashley
authors.forename: R C
authors.initials: RC
authors.lastname: Coombes
authors.forename: A L
authors.initials: AL
authors.lastname: Jones
authors.forename: H D
authors.initials: HD
authors.lastname: Sinnett
authors.forename: A G
authors.initials: AG
authors.lastname: Nash
mesh_terms: D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D003581:Cytodiagnosis; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008327:Mammography; D010808:Physical Examination; D012680:Sensitivity and Specificity