Mechanisms of oxidant-induced changes in erythrocytes.
There is an increasing body of experimental studies demonstrating the toxic effects of oxygen-derived free radicals. Evidence supports an important role for free radicals in ischemic injuries, inflammation, and chemical-induced tissue injury. Free radicals are involved in normal biochemical processes like oxidative reduction and cellular metabolism; however, they also mediate disease processes. The participation of oxygen free radicals in lysis of red cells is important in some situations of intravascular hemolysis. This article will review neutrophil-derived oxygen free radicals, emphasizing: (1) their effects on the erythrocyte and (2) how these effects may be attenuated.
Hatherill
J R
JR
Radian Corporation, El Segundo, CA 90245.
Till
G O
GO
Ward
P A
PA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects*; D016166:Free Radical Scavengers; D005609:Free Radicals; D006461:Hemolysis; D006801:Humans; D015227:Lipid Peroxidation; D009504:Neutrophils; D010100:Oxygen / Q000378:metabolism*
D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D010100:Oxygen