A novel metabolite of strychnine, 22-hydroxystrychnine.
1. An unknown metabolite of strychnine termed M-5 was isolated, from an incubation mixture using guinea pig liver microsomes, by repeated preparative t.l.c. 2. The structure of M-5 was shown to be 22-hydroxystrychnine by mass, n.m.r. and i.r. spectrometry. 3. 22-Hydroxystrychnine is a stable enol, a unique metabolite possessing a hydroxyl group on the double bond of the alicylic moiety.
Tanimoto
Y
Y
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Ohkuma
T
T
Oguri
K
K
Yoshimura
H
H
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006168:Guinea Pigs; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D013331:Strychnine / Q000031:analogs & derivatives* / Q000378:metabolism*
C070090:22-hydroxystrychnine; D013331:Strychnine