Influence of prostaglandin E1 on heavy proteinuria in slightly azotaemic diabetics.
Treatment of non-insulin-dependent diabetes mellitus patients with nephropathy of the nephrotic type using 40 micrograms prostaglandin E1 given intravenously twice daily for 4 weeks reduced the urinary protein concentration. Prostaglandin E1 also increased the total serum protein and serum albumin concentrations, and reduced creatinine clearance and plasma renin activity following frusemide loading. Treatment with the prostaglandin did not, however, significantly affect the blood urea nitrogen and the serum creatinine concentration. It is concluded that prostaglandin E1 has overt effects on diabetic nephropathy.
Okada
S
S
Third Department of Medicine, Okayama University Medical School, Japan.
Sato
K
K
Higuchi
T
T
Ichiki
K
K
Tanokuchi
S
S
Ishii
K
K
Hamada
H
H
Ota
Z
Z
D000368:Aged; D000419:Albuminuria; D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use*; D001798:Blood Proteins / Q000032:analysis / Q000652:urine; D003404:Creatinine / Q000378:metabolism / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000097:blood / Q000150:complications / Q000517:prevention & control*; D012083:Renin / Q000097:blood / Q000652:urine; D012709:Serum Albumin / Q000032:analysis
D001798:Blood Proteins; D012709:Serum Albumin; D003404:Creatinine; D012083:Renin; D000527:Alprostadil