Influence of vasoactive substances on uremic bleeding in rats.
Bleeding time is prolonged following resection of kidney tissue as well as after ureteral occlusion. Bilateral nephrectomy raises bleeding time from 17 to 67 min, and blood loss can be increased from 2 to 12 microliters/min. Plasmatic coagulation factors remain unchanged in uremic rats. There is no influence of various surgical interventions producing uremia on function of thrombocytes. In rats with intact kidney function and following bilateral nephrectomy a diminution of bleeding time is demonstrable after administration of histamine or captopril. Shortening of bleeding time by the antifibrinolytic substance p-aminomethylbenzoic acid seems to indicate an increased fibrinolytic activity in uremic rats.
Sprott
H
H
Friedrich Schiller University, Institute of Pharmacology and Toxicology, Jena, FRG.
Fleck
C
C
Bräunlich
H
H
D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology*; D002714:Chlorisondamine / Q000494:pharmacology; D004656:Enalapril / Q000494:pharmacology; D005260:Female; D005353:Fibronectins / Q000097:blood; D006632:Histamine / Q000494:pharmacology*; D009392:Nephrectomy; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014511:Uremia / Q000097:blood*; D014517:Ureteral Obstruction / Q000097:blood; D014667:Vasopressins / Q000494:pharmacology; D062366:para-Aminobenzoates
D005353:Fibronectins; D062366:para-Aminobenzoates; D014667:Vasopressins; D000804:Angiotensin II; C015668:4-aminomethylbenzoic acid; D004656:Enalapril; D006632:Histamine; D002216:Captopril; D002714:Chlorisondamine; D010129:4-Aminobenzoic Acid