title: Selective synthesis of 2,4-bis(O-methoxypolyethylene glycol)-6-chloro-s-triazine as a protein modifier.
abstract: 2,4-Bis(O-methoxypolyethylene glycol)-6-chloro-s-triazine, a protein modifier with two polyethylene glycol chains (activated PEG2) was synthesized from monomethoxypolyethylene glycol and cyanuric chloride using zinc oxide as a catalyst by the improved method of a previous study (Matsushima et al., Chem. Lett. 7, 773, 1980). The product was identified as activated PEG2 without contamination of by-products with chromatographic and structural analysis.
authors.affiliation: Research Laboratories, Sumitomo Pharmaceutical Co. Ltd., Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Kai
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: F
authors.initials: F
authors.lastname: Samizo
authors.forename: K
authors.initials: K
authors.lastname: Sakurai
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: Y
authors.initials: Y
authors.lastname: Inada
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000138:chemical synthesis*; D011506:Proteins / Q000187:drug effects*
chemical_list: D011506:Proteins; D011092:Polyethylene Glycols; C029761:2,4-bis(O-methoxypolyethylene glycol)-6-chloro-s-triazine