A genetic study of platelet adenylate cyclase activity: evidence for a single major locus effect in fluoride-stimulated activity.
The activity of membrane-bound platelet adenylate cyclase, when stimulated in vitro by several compounds (including fluoride), is significantly reduced in alcoholics compared with control subjects. We have begun a study of the genetics of this enzyme activity. Complex segregation analysis of basal (unstimulated) platelet adenylate cyclase activity in families reveals a mode of inheritance that cannot be accounted for by a simple mixed model of transmission. By contrast, adenylate cyclase activity stimulated by fluoride ion reveals a single major locus effect with a modest multifactorial background. These results suggest that a single factor in the second-messenger pathway may (a) account for the majority of individual differences in stimulation of adenylate cyclase of fluoride and (b) help explain the reduced activities previously observed in alcoholics.
Devor
E J
EJ
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Cloninger
C R
CR
Hoffman
P L
PL
Tabakoff
B
B
D000262:Adenylyl Cyclases / Q000097:blood / Q000235:genetics*; D000437:Alcoholism / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D001792:Blood Platelets / Q000201:enzymology*; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D015290:Second Messenger Systems
D000262:Adenylyl Cyclases; D005459:Fluorides