title: Soft filamentous woven polyester arterial prosthesis from China.
abstract: Woven polyester arterial prostheses have traditionally been known for their tight construction and smooth surface which has limited their healing capacity and resulted in poor attachment of their internal and external capsules. A new woven prototype has recently been developed in the Peoples' Republic of China. Among its unique features are its high physical porosity, softness and flexibility. This study undertook a series of in vitro tests to characterize its structure and physical properties in comparison with four commercial polyester grafts of North American origin. In addition, an animal trial was completed in which the new prototype was implanted as an infrarenal aortic substitute in 20 dogs for periods ranging from 4 h to 12 month. The in vitro tests confirmed a unique lightweight, highly porous, satin weave construction. Because of its high water permeability, preclotting was necessary before implantation. Once preclotted and installed, no significant blood loss was observed, and 19 of the 20 grafts remained patent at the sacrifice. Rapid full-width healing was achieved with tightly bound capsules, and more extensive tissue ingrowth was observed. Further work is needed to evaluate its long-term durability as an arterial substitute.
authors.affiliation: Research Laboratory of Cardiovascular Diseases, Shanghai Chest Hospital, China.
authors.forename: T J
authors.initials: TJ
authors.lastname: Rao
authors.forename: C
authors.initials: C
authors.lastname: Pan
authors.forename: R
authors.initials: R
authors.lastname: Guidoin
authors.forename: D
authors.initials: D
authors.lastname: Marceau
authors.forename: P E
authors.initials: PE
authors.lastname: Roy
authors.forename: M
authors.initials: M
authors.lastname: King
authors.forename: B
authors.initials: B
authors.lastname: Badour
authors.forename: J S
authors.initials: JS
authors.lastname: Rui
authors.forename: H M
authors.initials: HM
authors.lastname: Cheng
authors.forename: C L
authors.initials: CL
authors.lastname: Li
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery; D001158:Arteries; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D004285:Dogs; D004730:Endothelium, Vascular / Q000648:ultrastructure; D006488:Hemostasis, Surgical; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010539:Permeability; D011091:Polyesters / Q000032:analysis; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters