title: [Fatty emulsions in parenteral feeding following liver transplantation. A study of the neurotropic effect of MCT/LCT emulsions using EEG].
abstract: In the early postoperative period after liver transplantation a possible neurotropic side effect of middle-chain triglycerides used for total parenteral nutrition (TPN) was evaluated by EEG and Glasgow Coma Scale. Group I: no fat for TPN; Group II: 0.7 g/kg body weight (BW) and day, of MCT/LCT emulsion; Group III: 1.5 g/kg BW and day, of MCT/LCT emulsion. Only on postoperative day 5/6 significant differences in distribution of background activity in the EEG were seen between Group I and II. Patients in Group I showed more pathological EEG patterns (Mann-Whitney-U-test p less than 0.05). Per discriminant analysis an influence of applicated fatty acids on the registered background activity could be excluded. Instead an underlying rejection of the graft in 7 of 10 patients could be made responsible for deterioration of the EEG pattern. Following the presented data a negative neurotropic effect of MCT/LCT emulsions in the described dosages can be negated.
authors.affiliation: Zentrum Anästhesiologie, Abteilung IV, Medizinische Hochschule Hannover.
authors.forename: E R
authors.initials: ER
authors.lastname: Kuse
authors.forename: R M
authors.initials: RM
authors.lastname: Wassmann
authors.forename: B
authors.initials: B
authors.lastname: Ringe
authors.forename: H
authors.initials: H
authors.lastname: Bunzendahl
authors.forename: P
authors.initials: P
authors.lastname: Lehmkuhl
authors.forename: I
authors.initials: I
authors.lastname: Pichlmayr
authors.forename: R
authors.initials: R
authors.lastname: Pichlmayr
mesh_terms: D000328:Adult; D003128:Coma / Q000139:chemically induced* / Q000175:diagnosis; D004569:Electroencephalography; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced*; D012189:Retrospective Studies
chemical_list: D005217:Fat Emulsions, Intravenous
vernacular_title: Fettemulsionen in der parenteralen Ernährung nach Lebertransplantation. Eine Untersuchung zur neurotropen Wirkung von MCT/LCT-Emulsionen mittels EEG.