Piroxicam-induced reduction in osteopenia after external fixation of rabbit tibia.
Twelve rabbits were treated with a unilateral external fixator in one tibia for 12 weeks, while the other tibia served as an intact control. Half of the animals were also treated with 10 mg/kg/day of piroxicam, given in two daily oral doses. Changes in bone mineral content were determined using single photon absorptiometry. After 12 weeks, we found a 3 percent decrease in the bone mineral content in the tibia of the animals treated with piroxicam versus 9 percent in the nonpiroxicam group (P = 0.04). In the femurs, there was an insignificant decrease in bone mineral, 2 percent (piroxicam) and 1 percent (nonpiroxicam) respectively. The results indicate that piroxicam may reduce the osteopenia caused by external fixation.
Adolphson
P
P
Department of Orthopedics, Danderyd Hospital, Sweden.
Jonsson
U
U
Dalén
N
N
D015502:Absorptiometry, Photon; D000284:Administration, Oral; D000818:Animals; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D016267:External Fixators / Q000592:standards*; D005260:Female; D008297:Male; D010894:Piroxicam / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D011877:Radionuclide Imaging; D013978:Tibial Fractures / Q000150:complications* / Q000601:surgery
D010894:Piroxicam