title: [Bone remodeling after internal fixation with different stiffness plates: ultrastructural investigation].
abstract: Fourty adult New Zealand rabbits were used in this experiment. Four rabbits served as control and the rest 36 divided into 3 groups, each of which was fixed respectively with methylmethacrylate, titanium and strain-less steel plate on left intact tibiae. The cortical bone beneath the plate was harvested at 2, 4, 8 and 12 weeks after operation and observed by means of with transmission electron microscope. The major ultrastructural changes after internal fixation with different stiffness plates were alteration of osteocyte life cycle, perilacunar matrix, and disorder of osteoclast-osteoblast coupling. The greater the stiffness of the plate, the greater the ultrastructural change.
authors.affiliation: Ninth People's Hospital, Shanghai Second Medical University.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Chen
mesh_terms: D000818:Animals; D001860:Bone Plates; D005593:Fracture Fixation, Internal / Q000295:instrumentation*; D008768:Methylmethacrylates; D011817:Rabbits; D013193:Stainless Steel; D013977:Tibia / Q000648:ultrastructure*; D013978:Tibial Fractures / Q000473:pathology / Q000601:surgery*; D014025:Titanium
chemical_list: D008768:Methylmethacrylates; D013193:Stainless Steel; D014025:Titanium