Mitochondrial damage by active oxygen species in vitro.
Under in vitro conditions involving formation of active oxygen species, rat liver mitochondria were found to undergo swelling, peroxidative decomposition of lipids, and distinct disorganization of ultrastructure. Supplementation with free radical scavengers such as superoxide dismutase (SOD), methionine, histidine, and tryptophan accorded considerable protection to the organelle. A possible correlation between oxygen radicals, membrane integrity, and calcium functions is indicated.
Mehrotra
S
S
Ecotoxicology Section, Industrial Toxicology Research Centre, Lucknow, India.
Kakkar
P
P
Viswanathan
P N
PN
D000818:Animals; D002122:Calcium Chloride / Q000633:toxicity; D005609:Free Radicals; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000473:pathology; D010100:Oxygen / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013858:Thiobarbiturates / Q000378:metabolism
D005609:Free Radicals; D013858:Thiobarbiturates; D008315:Malondialdehyde; C029684:thiobarbituric acid; D002122:Calcium Chloride; D010100:Oxygen