Effect of omeprazole-induced hypergastrinaemia on the proliferation of colonic mucosal epithelial cells in the rat.
In the present study we have investigated the effects of proglumide (PRO) and somatostatin analog (SMS 201-995) on the mitotic activity of colonic mucosa in rats under basal conditions and after omeprazole (OM). The stathmokinetic method was used. Proglumide and OM were administered for 5 days, twice daily, SMS 201-995 on the 5th day of the experiment only, also twice daily. It was found that: 1) OM enhanced the proliferation of colonic mucosa, as well as increased serum gastrin, when compared to controls, 2) OM and PRO, when applied jointly, decreased the mitotic activity of the colonic epithelium, 3) PRO alone increased the colonic cell proliferation.
Pawlikowski
M
M
Institute of Endocrinology, Medical Academy of Lódź, Poland.
Wajs
E
E
Lewiński
A
A
Szkudliński
M
M
Rybicka
I
I
Sewerynek
E
E
D000704:Analysis of Variance; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D004336:Drug Antagonism; D004848:Epithelium / Q000187:drug effects; D005755:Gastrins / Q000097:blood*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000502:physiology*; D008297:Male; D015282:Octreotide / Q000494:pharmacology; D009853:Omeprazole / Q000494:pharmacology*; D011377:Proglumide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D005755:Gastrins; D011377:Proglumide; D009853:Omeprazole; D015282:Octreotide