Estimation of individual genetic and environmental profiles in longitudinal designs.
Parameter estimates obtained in the genetic analysis of longitudinal data can be used to construct individual genetic and environmental profiles across time. Such individual profiles enable the attribution of individual phenotypic change to changes in the underlying genetic or environmental processes and may lead to practical applications in genetic counseling and epidemiology. Simulations show that individual estimates of factor scores can be reliably obtained. Decomposition of univariate, and to a lesser extent of bivariate, phenotypic time series may yield estimates of independent individual G(t) and E(t), however, that are intercorrelated. The magnitude of these correlations depends somewhat on the autocorrelation structure of the underlying series, but to obtain completely independent estimates of genetic and environmental individual profiles, at least three measured indicators are needed at each point in time.
Boomsma
D I
DI
Department of Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Molenaar
P C
PC
Dolan
C V
CV
D006801:Humans; D008957:Models, Genetic; D010641:Phenotype; D012931:Social Environment; D014429:Twins, Dizygotic / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*