[A comparative study of the sensitivity and specific activity of an immunoenzyme test system for determining class-M antibodies to the hepatitis A virus].
The diagnostic value of the first experimental production batches of assay kit "DIAGN-A-HEP", produced at the Institute of Poliomyelitis and Viral Encephalitides (USSR Acad. Med. Sci.) and intended for the determination of IgM to hepatitis A virus (HAV) in the enzyme immunoassay (EIA), has been studied in comparison with that of the internationally known and widely approved commercial EIA system "HAVAB-MEIA" for the determination of antibodies to HAV (the product of Abbott, USA). The study has revealed that the EIA kit "DIAGN-A-HEP" is highly sensitive and specific, and the diagnostic value of this kit is not inferior to that of the commercial assay system "HAVAB-MEIA". On the basis of this study the use of the EIA kits "DIAGN-A-HEP" in medical practice has been allowed by the decree of the Ministry of Health of the USSR.
Kalashnikova
T V
TV
Karpovich
L G
LG
Nikitiuk
N M
NM
Gorbunov
M A
MA
Evreinova
E E
EE
Nel'ga
I V
IV
Kusov
Iu Iu
IuIu
Balaian
M S
MS
D005069:Evaluation Studies as Topic; D006506:Hepatitis A / Q000175:diagnosis / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D006510:Hepatitis B Antibodies / Q000097:blood; D006801:Humans; D007124:Immunoenzyme Techniques / Q000295:instrumentation*; D007075:Immunoglobulin M / Q000032:analysis*; D011933:Reagent Kits, Diagnostic; D014586:USSR; D014481:United States
D006508:Hepatitis Antibodies; D006510:Hepatitis B Antibodies; D007075:Immunoglobulin M; D011933:Reagent Kits, Diagnostic
Sravnitel'noe izuchenie chuvstvitel'nosti i spetsificheskoĭ aktivnosti immunofermentnoĭ test-sistemy dlia opredeleniia antitel klassa M k virusu gepatita A.