Antiradiation mixture and ionic-bond product of AET and adenyl nucleotides.
These experiments continued our line of inquiry into low-toxicity high-effectiveness radiomodifying agents obtained by binding radioprotective substances to biogenic and biologically active components or antidotes. Testes for toxicity and radioprotective effects were three preparations combining within one molecule AET and an adenyl nucleotide (AMP, ADP, or ATP). Ionic-bond formation was shown to have advantages over concomitant administration of AET and adenosine phosphoric acids as mixtures. The evidence obtained supports the rational foundation of the concept being developed by our laboratory.
Pantev
T
T
Medical Academy Research Institute of Nuclear Medicine, Radiobiology and Radiation Hygiene, Sofia, Bulgaria.
Georgieva
R
R
Topalova
S
S
D000227:Adenine Nucleotides / Q000494:pharmacology / Q000633:toxicity*; D000244:Adenosine Diphosphate / Q000494:pharmacology / Q000633:toxicity; D000249:Adenosine Monophosphate / Q000494:pharmacology / Q000633:toxicity; D000255:Adenosine Triphosphate / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D002588:Cesium Radioisotopes; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology / Q000633:toxicity*
D000227:Adenine Nucleotides; D002588:Cesium Radioisotopes; D004338:Drug Combinations; D000338:beta-Aminoethyl Isothiourea; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate