Reduction of oxotremorine-induced analgesia after chronic but not acute restraint stress.
The analgesic response (tail-flick latency) induced by the muscarinic cholinergic agonist oxotremorine was investigated in DBA/2 mice exposed to acute (a single 2 h session) and chronic (2 h once daily for 10 days) restraint stress. While a single exposure to stress did not influence the antinociceptive effects of the cholinergic agonist, chronic stress induced a clear-cut reduction of the oxotremorine-induced analgesia. The results show an involvement of cholinergic mechanisms in the adaptive modulation of nociception after chronic stressful events.
Badiani
A
A
Istituto di Psicobiologia e Psicofarmacologia del C.N.R., Roma, Italy.
Pavone
F
F
D000208:Acute Disease; D000700:Analgesics; D000818:Animals; D002908:Chronic Disease; D051379:Mice; D008811:Mice, Inbred DBA; D009043:Motor Activity / Q000187:drug effects; D010095:Oxotremorine / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000523:psychology*
D000700:Analgesics; D010095:Oxotremorine