title: [The immunomorphological characteristics of the appendix in a viral-bacterial lesion in children with appendicitis].
abstract: The characteristics of viral-bacterial lesion in the appendix of children with appendicitis are given by means of histologic, histochemical, immunomorphological and morphometric methods. Antigens of influenza viruses A, B, C, entero-, adeno- and paramyxoviruses were observed among which influenza C was found significantly more frequently (64.1%). Viral infection in the majority of cases (79.5%) was found in the association with opportunistic flora, more frequently with E. coli, and less R. aeruginosa and Klebsiella. Analysis of the immunomorphological shifts in the appendix indicated a peculiar dynamics of the antibody production in acute appendicitis: the enhancement of the IgG, IgD and IgE production and the decrease of the production of IgA and IgM. The viral-bacterial effect, the development of the immune responses with IgE hyperproduction and participation in this process of labrocytes and endocrine cells suggest the integration of the two pathogenetic mechanisms-infectious and allergic.
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Parkhomenko
authors.forename: A E
authors.initials: AE
authors.lastname: Ali-Riza
authors.forename: L S
authors.initials: LS
authors.lastname: Lozovskaia
authors.forename: V A
authors.initials: VA
authors.lastname: Grun'ko
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000956:Antigens, Viral / Q000032:analysis; D001064:Appendicitis / Q000276:immunology / Q000473:pathology*; D001065:Appendix / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D001419:Bacteria / Q000302:isolation & purification; D001424:Bacterial Infections / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D002481:Cellulitis / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D014777:Virus Diseases / Q000276:immunology / Q000382:microbiology / Q000473:pathology*
chemical_list: D000956:Antigens, Viral; D007136:Immunoglobulins
vernacular_title: Immunomorfologicheskaia kharakteristika cherveobraznogo otrostka pri virusno-bakterial'nom ego porazhenii u deteĭ s appenditsitom.