[The use of the indirect hemagglutination reaction for the serodiagnosis of HIV infection].
An assay system, based on the passive hemagglutination test and permitting the serodiagnosis of HIV infection with correct results in more than 99% of cases, has been developed. Three kinds of freeze-dried erythrocyte diagnostica (with shelf life exceeding 6 months), possessing high serological activity and sensitized with recombinant gene-engineering polypeptides, have been obtained. The proposed assay system is highly promising for mass examination of sera for the presence of antibodies to HIV due to the simplicity of assay techniques, the possibility of storing the diagnostica within a wide range of temperatures (4 degrees-30 degrees C) and obtaining results in a short time (3 hours).
Konikova
R E
RE
Ertte
A P
AP
Leont'eva
M M
MM
Noskov
F S
FS
Sukhanova
L L
LL
Sazonov
A E
AE
Gol'tsov
V A
VA
Zaĭtsev
I Z
IZ
Andzhaparidze
O G
OG
D015492:AIDS Serodiagnosis / Q000379:methods*; D002353:Carrier State / Q000175:diagnosis; D004912:Erythrocytes / Q000276:immunology; D005189:False Positive Reactions; D005612:Freeze Drying; D015686:Gene Products, env; D015683:Gene Products, gag; D015658:HIV Infections / Q000175:diagnosis; D006679:HIV Seropositivity / Q000175:diagnosis; D015497:HIV-1 / Q000276:immunology; D006386:Hemagglutination Tests / Q000379:methods*; D006801:Humans; D011994:Recombinant Proteins
D015686:Gene Products, env; D015683:Gene Products, gag; D011994:Recombinant Proteins
Primenenie reaktsii nepriamoĭ gemaggliutinatsii dlia serodiagnostiki VICh-infektsii.