title: Elevated medial-frontal cerebral blood flow in obsessive-compulsive patients: a SPECT study.
abstract: Regional cerebral blood flow was measured with single photon emission computed tomography in 10 obsessive-compulsive patients and eight comparison subjects. The patients had a significantly higher ratio of medial-frontal to whole cortex blood flow; this was unrelated to symptom severity but was correlated negatively with anxiety. No differences in orbital-frontal blood flow were found.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD.
authors.forename: S R
authors.initials: SR
authors.lastname: Machlin
authors.forename: G J
authors.initials: GJ
authors.lastname: Harris
authors.forename: G D
authors.initials: GD
authors.lastname: Pearlson
authors.forename: R
authors.initials: R
authors.lastname: Hoehn-Saric
authors.forename: P
authors.initials: P
authors.lastname: Jeffery
authors.forename: E E
authors.initials: EE
authors.lastname: Camargo
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000503:physiopathology; D002540:Cerebral Cortex / Q000098:blood supply / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime