title: [Clinical and experimental study of tablet cucumber vine compound in treating essential hypertension].
abstract: 389 patients with essential hypertension were divided into two groups randomly. 241 patients were treated by tablet of cucumber vine compound and 148 patients by tablet of hypotension compound as control. The symptomatic marked improvement and total effective rate were 63.1% and 81.7% in the treated group and 39.2% and 67.0% (P less than 0.01) in the control group respectively. The marked effective rate in decrease of blood pressure and total effective rate were 52.7%, 90.9% and 58.1%, 92.6% (P greater than 0.05) respectively. Experiments with animals showed that tablet cucumber vine compound possessed persistently decreasing effect on the blood pressure and marked effect on increasing coronary blood flow and improving myocardial contraction. Clinical observation and toxicological test proved that tablet cucumber vine compound had no toxicity and had few side effects and that it was an effective, safe medicine for essential hypertension.
authors.affiliation: Geriatrics Institute, 1st Sanatorium, Dalian.
authors.forename: G L
authors.initials: GL
authors.lastname: Lu
authors.forename: W X
authors.initials: WX
authors.lastname: Yuan
authors.forename: Y J
authors.initials: YJ
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D011817:Rabbits; D011897:Random Allocation; D013607:Tablets
chemical_list: D004365:Drugs, Chinese Herbal; D013607:Tablets