title: Effect of sodium fluoride on early stages of otosclerosis.
abstract: The present investigation evaluates the effectiveness of NaF treatment in modifying the natural course of subclinical otosclerosis, as monitored by the stapedius reflex. The study was carried out on 128 relatives of patients suffering from surgically confirmed footplate otosclerosis. The diagnosis of subclinical otosclerosis was made on the basis of presence of the on-off effect. One group of subjects was treated with NaF in doses ranging from 6 to 16 mg according to age. The treatment lasted 2 years. A second group served as a control. Changes in stapedius reflex morphology were evaluated at 1, 2, and 5 years from the onset of treatment. The investigation demonstrated that NaF has a stabilizing effect on early otosclerosis. This drug, in fact, arrests the disease process in more than 60 percent of ears at the 2-year follow-up and in more than 50 percent at 5 years. A program of secondary prevention of otosclerosis by NaF is suggested.
authors.affiliation: ENT Department, University of Verona, Ospedale Borgo Roma, Verona, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Colletti
authors.forename: F G
authors.initials: FG
authors.lastname: Fiorino
mesh_terms: D000293:Adolescent; D000328:Adult; D001309:Auditory Threshold / Q000502:physiology; D002648:Child; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010040:Otosclerosis / Q000188:drug therapy* / Q000503:physiopathology; D012022:Reflex, Acoustic; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D013198:Stapedius / Q000503:physiopathology
chemical_list: D012969:Sodium Fluoride