Withdrawal like responses of rat hippocampal slices following brief exposure to morphine.
An acutely acquired dependence was investigated in rat hippocampal slices after brief exposure to morphine. Morphine augmented the population spike amplitude. Naloxone not only reversed the augmentation but decreased the amplitude to a level below that of the control. The inhibitory effect of naloxone correlated with the period of preincubation with morphine. These results suggested that the decreased response may indicate the withdrawal state acquired in vitro.
Kusama
T
T
Department of Physiology and Anatomy, Nihon University College of Pharmacy, Chiba, Japan.
Murakoshi
Y
Y
Murakami
H
H
D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D009270:Naloxone; D009020:Morphine