title: Partially biodegradable polyacrylic-polyester composites for internal bone fracture fixation.
abstract: New partially resorbable composite formulations based on components used in surgery were synthesized in rod form (length 15-20 mm, diameter 4 mm). The biostable components were poly(methyl methacrylate) in hydrophobic implants and poly(2-hydroxy ethyl methacrylate) in hydrophilic ones. The biodegradable components were commercially available suture yarn made from poly (alpha-hydroxy esters): polyglycolide, a polyester derived from glycolic acid; and a copolyester of glycolic and lactic acids, polyglactin 910. Biodegradation in phosphate-buffered solution at pH 7.0 and 37 +/- 0.5 degrees C was analysed gravimetrically. There was no measurable loss of mass after treatment for 20-25 d. Composite microstructure was examined by phase-contrast, cross-polarized light microscopy.
authors.affiliation: Instituto de Ciencia y Tecnología de Polímeros, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: San Román
authors.forename: P
authors.initials: P
authors.lastname: Guillén García
mesh_terms: D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D003188:Composite Resins / Q000032:analysis; D005593:Fracture Fixation, Internal / Q000295:instrumentation*; D008853:Microscopy; D011091:Polyesters / Q000032:analysis; D011109:Polymethacrylic Acids / Q000032:analysis; D019736:Prostheses and Implants
chemical_list: D001672:Biocompatible Materials; D003188:Composite Resins; D011091:Polyesters; D011109:Polymethacrylic Acids