[Studies on the chemistry of O,N- and S,N-containing heterocylics. 10. Synthesis and biologic activity of 2-substituted 2-ethylbenzoxazoles].
2-Vinylbenzoxazole (3) is obtained by condensation of acrylic acid with 2-aminophenol in a mixture of phosphorus pentoxide/methansulfonic acid. Interaction of 3 with N-, O-, and C-nucleophiles yields 2-substituted 2-ethyl-benzoxazoles. Compounds 8a, 8b and 8e show analgetic activity in mice. Moreover, fungicide, insecticide and nematocide activity of some compounds is found.
Bartsch
H
H
Institut für Pharmazeutische Chemie, Universität Wien, Osterreich.
Erker
T
T
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000969:Antinematodal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007306:Insecticides / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests
D000700:Analgesics; D000935:Antifungal Agents; D000969:Antinematodal Agents; D001583:Benzoxazoles; D007306:Insecticides
Studien zur Chemie O,N- und S,N-haltiger Heterocyclen, 10. Mitt: Synthese und biologische Aktivität von 2-substituierten 2-Ethylbenzoxazolen.