Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin.
We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These data, in agreement with our previous reports, suggest that the dbl protooncogene is expressed in a highly tissue-specific manner and indicate that this gene may be involved in the growth and differentiation of some cells of neuroectodermal origin.
de Franciscis
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Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, Università di Napoli, Italy.
Rosati
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Colucci-D'Amato
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GL
Eva
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Vecchio
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D000818:Animals; D001706:Biopsy; D002460:Cell Line; D004475:Ectoderm; D015870:Gene Expression; D020662:Guanine Nucleotide Exchange Factors; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics*; D009423:Nervous System Neoplasms / Q000235:genetics* / Q000473:pathology; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D014158:Transcription, Genetic; D014162:Transfection
D020662:Guanine Nucleotide Exchange Factors; C057811:MCF2 protein, human; C512843:Mcf2 protein, mouse; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D011505:Protein-Tyrosine Kinases