title: [Rhino-cerebral mucormycosis and hematological neoplasia].
abstract: Mucormycosis is a rare infection that occurs in immunocompromised patients. The rhinocerebral form presents in diabetics as a severe necrotizing sinusitis and is not frequent in patients with haematologic malignancies. Diagnosis requires direct examination and culture of biopsy specimens. Two patients with rhinocerebral mucormycosis and haematologic neoplasms (Non-Hodgkin's lymphoma and acute myeloblastic leukaemia) are described. Both patients had severe drug-induced neutropenia when the infection appeared. One patient died in spite of aggressive treatment with surgery and amphotericin.
authors.affiliation: Servicio de Medicina Interna, Hospital La Paz, Madrid.
authors.forename: V
authors.initials: V
authors.lastname: Pintado
authors.forename: M E
authors.initials: ME
authors.lastname: Valencia
authors.forename: J M
authors.initials: JM
authors.lastname: López-Dupla
authors.forename: P
authors.initials: P
authors.lastname: Lavilla
authors.forename: J
authors.initials: J
authors.lastname: Feliú
authors.forename: A
authors.initials: A
authors.lastname: Gil
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy / Q000209:etiology*; D010000:Osteitis / Q000209:etiology*; D012852:Sinusitis / Q000209:etiology*; D012886:Skull
chemical_list: D000666:Amphotericin B
vernacular_title: Mucormicosis rinocerebral y neoplasia hematológica.