[Changes in the humoral response to sheep erythrocytes based on data from a determination of the level and classes of antibodies in mice immunized with purified staphylococcal anatoxin].
The intensity and direction of the modulation of humoral immune response, induced by the action of purified staphylococcal toxoid (PST), depend on the dose of the preparation, the dose of the test antigen, the scheme of the experiment, the time of the registration of its results and the genotype of animals. PST induces the modulation of the synthesis of both IgM and IgG antibodies. The injection of small divided doses of PST enhances immune response to heterologous antigen, while a single inoculation of the total dose produces no such effect.
Semenova
I B
IB
Akatov
A K
AK
D000818:Animals; D000906:Antibodies / Q000097:blood*; D000917:Antibody Formation / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology*; D007114:Immunization / Q000379:methods; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012756:Sheep; D013208:Staphylococcal Toxoid / Q000276:immunology*; D013997:Time Factors
D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D013208:Staphylococcal Toxoid
Izmenenie gumoral'nogo otveta na éritrotsitov barana po dannym opredeleniia urovnia i klassov antitel u mysheĭ, immunizirovannykh anatoksinom stafilokokkovym ochishchennym.