[The renin-angiotensin-aldosterone system and arterial hypertension in patients with rheumatoid arthritis].
Renin-angiotensin-aldosterone++ system was investigated in 60 patients suffering from rheumatoid arthritis. Forty-four of them (group 1) had arterial hypertension (144 +/- 4/94 +/- 2 mm Hg), sixteen were free of hypertension (120 +/- 3/80 +/- 1 mm Hg). Twenty-nine control subjects comparable by AH standing and demographic parameters had essential hypertension stage IB-IIA by A. L. Myasnikov classification (141 +/- 3/89 +/- 1 mm Hg). A tendency to renin suppression was dominating in 72% of group 1 patients (plasma renin activity less than 1.0 ng/ml/h). In this group there appeared high concentrations of A II (14.2 +/- 3.1 pg/ml) and plasma aldosterone++ (238 +/- 94 ng/ml). Rheumatoid vasculitis manifested in 86% of patients. Control subjects exhibited plasma renin activity greater than 3.0 ng/ml/hin 48%, average A II concentration was similar to that of group 1 (12.4 +/- 2.7 ng/ml/h, p greater than 0.05), plasma aldosterone++ level was significantly lower (176 +/- 29 ng/ml, p less than 0.05). Correlations were established between A II concentration and ESR (r = 0.39, p less than 0.05), A II and rheumatoid factor titers (r = 0.40, p less than 0.05). These indicate that immunopathological reactions are responsible for shifts in renin-angiotensin-aldosteron system in hypertensive rheumatoid arthritis subjects.
Samoriadova
O S
OS
Zharova
E A
EA
Masenko
V P
VP
Balabanova
R M
RM
Vil'chinskaia
M Iu
MIu
Nasonov
E L
EL
D000328:Adult; D000450:Aldosterone / Q000502:physiology*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008875:Middle Aged; D012084:Renin-Angiotensin System / Q000502:physiology*
D000450:Aldosterone
Sistema renin-angiotenzin-al'dosteron i arterial'naia gipertenziia u bol'nykh revmatoidnym artritom.