title: Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor.
abstract: The green mamba, Dendroaspis angusticeps, has two protein toxins that bind to the muscarinic acetylcholine receptor. The sequence of muscarinic toxin 2 was determined with an automatic gas phase sequencer. The C-terminal residue is Asp as determined by hydrazinolysis and amino acid analysis. Toxin 2 has 65 amino acid residues and a formula weight of 7040. It is homologous to a large number of other snake venom toxins as short alpha-neurotoxins, cardiotoxins/cytotoxins and angusticeps-type toxins of mamba venoms. The sequence is confirmed in the accompanying article (Ducancel, F., Rowan, E.G., Cassart, E., Harvey, A. L., Menez, A. and Boulain, J.-C. Toxicon 29, 516-520, 1991).
authors.affiliation: Department of Biochemistry, Biomedical Centre, Uppsala, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Karlsson
authors.forename: C
authors.initials: C
authors.lastname: Risinger
authors.forename: M
authors.initials: M
authors.lastname: Jolkkonen
authors.forename: C
authors.initials: C
authors.lastname: Wernstedt
authors.forename: A
authors.initials: A
authors.lastname: Adem
mesh_terms: D000595:Amino Acid Sequence; D004546:Elapid Venoms / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D011976:Receptors, Muscarinic / Q000378:metabolism*; D030162:Reptilian Proteins; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004546:Elapid Venoms; D009498:Neurotoxins; D011976:Receptors, Muscarinic; D030162:Reptilian Proteins; C070124:muscarinic toxin 2