[Adrenocortical function in children with connective tissue syndromes and funnel chest deformation].
Measurement of the content of C-21-corticosteroids in the diurnal urine by thin-layer chromatography has demonstrated that in children with isolated and syndromal forms of funnel-like chest deformation, grades II and III, adrenocortical function is decreased. In preschool children, such a decrease is accompanied by proneness to the tense biosynthesis of glucocorticoids. Children with congenital hereditary connective syndromes manifest adrenocortical dysfunction, most characteristic of Marfan's syndrome, and, to a less degree, of Ehlers-Danlos syndrome and unclassified complex of developmental defects with the Marfan-like phenotype. In view of this fact, the children with Marfan's, Ehlers-Danlos syndromes and with the unclassified complex of developmental defects with the Marfan-like phenotype and children with funnel-like chest deformation, grades II and III, should be given glucocorticoid hormones in stressful conditions (severe diseases, traumas, operations).
Luk'ianov
S V
SV
Mishchenko
V B
VB
Iablonovskaia
T S
TS
Rudakov
S S
SS
D000293:Adolescent; D000302:Adrenal Cortex / Q000187:drug effects / Q000503:physiopathology*; D000304:Adrenal Cortex Function Tests; D002648:Child; D002675:Child, Preschool; D003240:Connective Tissue Diseases / Q000188:drug therapy / Q000503:physiopathology*; D005660:Funnel Chest / Q000188:drug therapy / Q000503:physiopathology*; D005938:Glucocorticoids / Q000096:biosynthesis / Q000627:therapeutic use; D006801:Humans
D005938:Glucocorticoids
Funktsional'noe sostoianie kory nadpochechnikov u deteĭ s soedinitel'notkannymi sindromami i voronkoobraznoĭ deformatsieĭ grudnoĭ kletki.