title: Multiple modes of engrailed regulation in the progression towards cell fate determination.
abstract: The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed-independent mode of maintenance.
authors.affiliation: Department of Biochemistry and Biophysics, UCSF School of Medicine 94143-0448.
authors.forename: J
authors.initials: J
authors.lastname: Heemskerk
authors.forename: S
authors.initials: S
authors.lastname: DiNardo
authors.forename: R
authors.initials: R
authors.lastname: Kostriken
authors.forename: P H
authors.initials: PH
authors.lastname: O'Farrell
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D004475:Ectoderm / Q000166:cytology; D005786:Gene Expression Regulation; D006706:Homeostasis; D006358:Hot Temperature; D009154:Mutation; D011401:Promoter Regions, Genetic; D013234:Stem Cells / Q000166:cytology; D014921:Wings, Animal / Q000196:embryology