The Lang strain of reovirus serotype 1 and the Dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon.
Replication of the Dearing strain of reovirus serotype 3 in mouse L cells was decreased 17- to 100-fold when a saturating dose of beta interferon (1,000 IU/ml) was used. Replication of the Lang strain of reovirus serotype 1 was inhibited only two- to threefold under similar conditions. It therefore appears that closely related strains of reovirus differ in their sensitivities to beta interferon treatment of mouse L cells.
Jacobs
B L
BL
Department of Microbiology, Arizona State University, Tempe 85287-2701.
Ferguson
R E
RE
D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology*; D007739:L Cells; D012089:Mammalian orthoreovirus 3 / Q000254:growth & development*; D051379:Mice; D012087:Reoviridae / Q000254:growth & development*; D013045:Species Specificity; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects
D007370:Interferon Type I