Measurement of light touch perception threshold by contingent negative variation.
An objective method developed to measure the threshold of light touch perception using contingent negative variation (CNV) is described. The light touch stimulus was a slight indentation of the skin produced through a displacement controlled stimulating probe (tip diameter of 2 mm). It was applied as the conditioning (S1) stimulus of the classical CNV paradigm of S1, S2, and R. To increase the CNV amplitude, the S2 stimulus was either a red or a yellow LED. The subjects were required to respond to only one of two by pressing a button. When the light touch stimulus was perceived, the CNV was recorded in all 19 healthy adult volunteers. In 14 of them, a systematic determination of the threshold of the ball of the thumb and index finger, thenar, hypothenar, face, shoulder, anterior thigh, foot dorsum and great toe ball, have been done. The thresholds of the light touch perception as defined by objective CNV measurement are very close to the results of the subjective psychophysiological determinations in normals. The amplitude of the averaged CNV (12 responses) started to decrease when stimulus intensity was reduced to the point that the subjects were able to perceive only a fraction of the presented touch stimuli. We believe, therefore, that the objective CNV determination of the light touch perception threshold is precise and sensitive enough to be used in research as well as in clinical applications.
Prevec
T S
TS
Division of Restorative Neurology and Human Neurobiology, Baylor College of Medicine, Houston, TX 77030.
Berić
A
A
D000328:Adult; D003265:Contingent Negative Variation; D004566:Electrodes; D005145:Face / Q000294:innervation; D006225:Hand / Q000294:innervation; D006801:Humans; D007866:Leg / Q000294:innervation; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology*; D012782:Shoulder / Q000294:innervation; D012867:Skin / Q000294:innervation; D014110:Touch / Q000502:physiology*