[Benzonal--a phenobarbital-type of inducer of the mono-oxygenase system].
It has been found that the Soviet anticonvulsant drug Benzonal is an inducer of the liver cytochrome P-450 of the phenobarbital type. The drug causes formation of the cytochrome P-450 form which is immunologically identical to the phenobarbital inducible form of the hemoprotein with identical molecular mass determined with the SDS-gel electrophoresis method in PAAG. The microsomes, obtained from the rats treated with Benzonal display increased rates of metabolism of 7-pentoxiresorufin and 16 beta-hydroxylation of androstenedione which are specific substrates for the cytochrome P-450b.
Novozheeva
T P
TP
Saratikov
A S
AS
Grishanova
A Iu
AIu
Gutkina
N I
NI
Akhmedzhanov
R R
RR
Khatsenko
O G
OG
Kozlovskaia
N E
NE
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology*; D002384:Catalysis / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis / Q000096:biosynthesis / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D007527:Isoenzymes / Q000032:analysis / Q000096:biosynthesis / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D010105:Oxygenases / Q000032:analysis / Q000096:biosynthesis / Q000187:drug effects*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D000927:Anticonvulsants; D001463:Barbiturates; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; C002915:benzobarbital; D010634:Phenobarbital
Benzonal--induktor monooksigenaznoĭ sistemy fenobarbitalovogo tipa.