Plasminogen polymorphism in Libyans: description of a new rare variant.
The genetic polymorphism of human plasminogen (PLG) was investigated in Libyans using wide-scale ultrathin-layer polyacrylamide isoelectric focusing with subsequent immunoblotting. The 2 common alleles, PLG*A and PLG*B, and 4 previously reported rare ones, PLG*A3, PLG*M4, PLG*B1 and PLG*B2, were observed. In addition, a new intermediate rare allele designated PLG*MTripoli (PLG*MT) was encountered. The estimated allele frequencies for the genes PLG*A, PLG*B, PLG*A3, PLG*MT, PLG*M4, PLG*B1 and PLG*B2 were 0.6409, 0.3091, 0.0182, 0.0045, 0.0091, 0.0045 and 0.0136, respectively. The isolated probability of exclusion in cases of disputed paternity among Libyans is 23.3%.
Sebetan
I M
IM
Department of Laboratory Medicine and Pathology, Hamad General Hospital, Doha, Qatar.
D000483:Alleles; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D008002:Libya; D008297:Male; D010958:Plasminogen / Q000235:genetics* / Q000302:isolation & purification; D011110:Polymorphism, Genetic / Q000235:genetics*
D010958:Plasminogen