title: Cytotoxic principles of Securinega virosa: virosecurinine and viroallosecurinine and related derivatives.
abstract: Virosecurinine (1) and viroallosecurinine (2) were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. A comparison of the cytotoxicity of 1 and several of its derivatives indicates that an alpha,beta- and a gamma,delta-unsaturated lactone located in a strained ring system, such as rings -B, -C, and -D of 1, is structurally required for significant cytotoxicity.
authors.affiliation: Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
authors.forename: H
authors.initials: H
authors.lastname: Tatematsu
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: T H
authors.initials: TH
authors.lastname: Yang
authors.forename: J J
authors.initials: JJ
authors.lastname: Chang
authors.forename: T T
authors.initials: TT
authors.lastname: Lee
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D001381:Azepines; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D007783:Lactones; D010880:Piperidines; D010946:Plants, Medicinal / Q000032:analysis*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001381:Azepines; D007783:Lactones; D010880:Piperidines; C012607:virosecurinine