title: Altered susceptibility of 2f1-f2 acoustic-distortion products to the effects of repeated noise exposure in rabbits.
abstract: Hearing sensitivity and the generation of acoustic-distortion products at 2f1-f2 were examined systematically in behaviorally trained rabbits, before, during, and following regular exposure to a 95-dB SPL octave band of noise, centered at 1 kHz. During the exposure period, the octave-band noise was interrupted once every 24 h in order to monitor the progressive loss in auditory function using tests of behavioral threshold and distortion-product otoacoustic emissions (DPOAEs). When low-frequency DPOAEs from 1-4 kHz diminished to noise-floor levels, i.e., when their amplitudes were reduced by about 20-30 dB, the exposure was terminated. Subsequent recovery of behavioral thresholds and DPOAE amplitudes and detection 'thresholds' was evaluated at regular intervals over a 3-week post-exposure period. Following the recovery period, the rabbits again received the identical exposure/recovery treatment until a permanent 10 dB or greater loss in DPOAE amplitudes was achieved for any point of measurement between 2-10 kHz. The primary result was that the number of days of overstimulation required for rabbits to reach the criterion loss in DPOAE amplitudes increased for each successive exposure session. In addition, DPOAEs accurately tracked the frequency pattern described by the behavioral threshold shifts during both the development and recovery stages of exposure.
authors.affiliation: Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas.
authors.forename: D J
authors.initials: DJ
authors.lastname: Franklin
authors.forename: B L
authors.initials: BL
authors.lastname: Lonsbury-Martin
authors.forename: B B
authors.initials: BB
authors.lastname: Stagner
authors.forename: G K
authors.initials: GK
authors.lastname: Martin
mesh_terms: D000818:Animals; D001299:Audiometry; D001522:Behavior, Animal; D004423:Ear / Q000502:physiology*; D009622:Noise; D010469:Perceptual Distortion / Q000502:physiology*; D011817:Rabbits; D012684:Sensory Thresholds; D013997:Time Factors