Steroid-dependent nephrotic syndrome following renal transplantation for congenital nephrotic syndrome.
A boy developed recurrent steroid-responsive nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. The first episode was associated with mild tubulointerstitial rejection on kidney biopsy. Subsequent episodes showed normal histology by light microscopy and epithelial foot process fusion on electron microscopy, consistent with minimal change nephrotic syndrome. Serum analysis for soluble immune response suppressor was negative pre-nephrectomy, positive during each bout of nephrotic syndrome, and negative during each remission. This case represents de novo occurrence of steroid-sensitive minimal change nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. We stress the need for histological examination of the renal allograft to diagnose rejection, recurrent disease, or de novo disease.
Lane
P H
PH
Division of Pediatric Nephrology, University of Minnesota Hospitals, Minneapolis.
Schnaper
H W
HW
Vernier
R L
RL
Bunchman
T E
TE
D002675:Child, Preschool; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D016030:Kidney Transplantation / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced* / Q000151:congenital / Q000473:pathology; D011241:Prednisone / Q000009:adverse effects*; D012008:Recurrence; D012086:Reoperation; D013491:Suppressor Factors, Immunologic / Q000097:blood
D013491:Suppressor Factors, Immunologic; C013256:soluble immune response suppressor; D011241:Prednisone