title: Extending cardiac allograft ischemic time and donor age: effect on survival and long-term cardiac function.
abstract: Of 219 heart transplant patients with follow up for at least 3 months after transplantation, cardiac allograft ischemic time was more than 4 hours in 28% and more than 5 hours in 10%. In 1988 and 1989 grafts with ischemic times longer than 4 hours were used in 44% and 45% of cases, respectively. Overall, donor age has been 35 or more years in 22% and 45 or more in 9%. In 1989 donor age was 35 or more years in 39% of cases and 45 or more in 18%. Fifteen of 20 grafts from donors 45 years or older were used for patients aged 50 or older. There was no relationship between donor age or ischemic time and 90-day graft loss. At 3 and 12 months, cardiac function, assessed by treadmill exercise duration, radionuclide angiography, and rest and peak supine exercise hemodynamics, was also unrelated to donor age or ischemic time. Therefore by careful selection of appropriate donors, extending both graft ischemic time and donor age has increased the potential donor pool and has not to date been associated with increased graft loss or adverse effects on cardiac function 3 months and 1 year after heart transplantation.
authors.affiliation: Department of Medicine (Division of Cardiology), University of Western Ontario, University Hospital, London, Canada.
authors.forename: P W
authors.initials: PW
authors.lastname: Pflugfelder
authors.forename: N R
authors.initials: NR
authors.lastname: Singh
authors.forename: F N
authors.initials: FN
authors.lastname: McKenzie
authors.forename: A H
authors.initials: AH
authors.lastname: Menkis
authors.forename: R J
authors.initials: RJ
authors.lastname: Novick
authors.forename: W J
authors.initials: WJ
authors.lastname: Kostuk
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D016027:Heart Transplantation / Q000401:mortality* / Q000502:physiology; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation; D013997:Time Factors; D014019:Tissue Donors; D009927:Tissue and Organ Procurement