title: Tachycardia-induced cardiomyopathy: effects on blood flow and capillary structure.
abstract: Chronic supraventricular tachycardia (SVT) causes a dilated cardiomyopathy. A potential factor contributing to the development of SVT-induced cardiomyopathy is abnormal myocardial blood flow (MBF). The purpose of this study was to relate changes in left ventricular (LV) function, MBF, and capillary structure with the development of SVT-induced cardiomyopathy. LV function and MBF were measured in two groups of conscious pigs: sham control (CON; n = 8) and after 3 wk of atrial pacing (SVT; 240 beats/min; n = 8) using echocardiography-catheterization and microspheres. Measurements were made under three states: 1) at rest with a basal heart rate, 2) during rapid atrial pacing (240 beats/min), and 3) during adenosine infusion (1.5 microM.kg-1.min-1) without pacing. LV capillary density, diameter, wall thickness, and capillary-myocyte distance were measured in four additional pigs from each group. LV fractional shortening was lower, and left atrial pressure was significantly higher in the SVT group compared with CON at rest, during pacing, and with adenosine (P less than 0.05). In the CON group, average LV-MBF at rest was 2.0 +/- 0.2 ml.min-1.g-1, increased with pacing to 3.0 +/- 0.2 ml.min-1.g-1 (P less than 0.05), and increased further with adenosine to 4.1 +/- 0.3 ml.min-1.g-1 (P less than 0.05). In all states, SVT LV-MBF was significantly reduced vs. CON (P less than 0.05); SVT LV-MBF was 0.8 +/- 0.2 ml.min-1.g-1 at rest, increased to 1.3 +/- 0.3 ml.min-1.g-1 with rapid pacing (P less than 0.05), and remained unchanged during adenosine (1.3 +/- 0.4 ml.min-1.g-1).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston 29425.
authors.forename: F G
authors.initials: FG
authors.lastname: Spinale
authors.forename: J L
authors.initials: JL
authors.lastname: Zellner
authors.forename: M
authors.initials: M
authors.lastname: Tomita
authors.forename: G E
authors.initials: GE
authors.lastname: Tempel
authors.forename: F A
authors.initials: FA
authors.lastname: Crawford
authors.forename: M R
authors.initials: MR
authors.lastname: Zile
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D002196:Capillaries / Q000473:pathology / Q000648:ultrastructure; D002304:Cardiac Pacing, Artificial; D009202:Cardiomyopathies / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D003326:Coronary Circulation / Q000187:drug effects; D013552:Swine; D013610:Tachycardia / Q000150:complications*; D016276:Ventricular Function
chemical_list: D000241:Adenosine