title: Determination of bencyclane in human plasma by means of capillary gas chromatography and nitrogen-phosphorus selective detection.
abstract: A sensitive and specific method for the determination of bencyclane in human plasma is presented. Bencyclane was extracted from human plasma with two 3-ml volumes of isooctane and was shaken for 10 min. The organic phase was separated and evaporated to dryness at 40 degrees C under a nitrogen stream. The residue was dissolved and an aliquot was injected into the gas chromatograph. The separation was performed with a DB-17 column with helium as the carrier gas. Nitrogen-selective detection was performed. The quantification was performed with the signal output. The limit of detection was 1 ng/ml.
authors.affiliation: R & D, Referat Pharmakokinetik, Thiemann Arzneimittel GmbH, Waltrop, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Lohmann
authors.forename: N
authors.initials: N
authors.lastname: Diekmann
authors.forename: R
authors.initials: R
authors.lastname: Walters
authors.forename: R
authors.initials: R
authors.lastname: Kraft
mesh_terms: D001537:Bencyclane / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D009584:Nitrogen; D009795:Octanes; D010758:Phosphorus
chemical_list: D009795:Octanes; D010758:Phosphorus; D001537:Bencyclane; D009584:Nitrogen; C045798:2,2,4-trimethylpentane