Cerebral vascular effects of peptide histidine methionine in canine and bovine species.
Peptide histidine methionine (PHM) is a neuropeptide with structural homology to vasoactive intestinal peptide (VIP), itself a putative vasodilatory neurotransmitter. Intra-arterial administration of PHM caused a transient, dose-dependent increase in canine vertebral artery blood flow in vivo. PHM was less potent in this effect than VIP. The interaction of PHM with the vasoconstrictor amines, norepinephrine, histamine, and serotonin, was examined using isolated strips of the bovine middle cerebral artery. PHM shifted the concentration-response curves for vasocontraction by norepinephrine and histamine to the right but did not affect the vasocontraction induced by serotonin. These results suggest that PHM may have a role in the regulation of the cerebral circulation.
Suzuki
Y
Y
Department of Neurosurgery, Nagoya University School of Medicine, Japan.
Satoh
S
S
Lederis
K
K
Rorstad
O
O
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D002049:Burimamide / Q000494:pharmacology; D002417:Cattle; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology; D007269:Injections, Intra-Arterial; D009638:Norepinephrine / Q000494:pharmacology; D010451:Peptide PHI / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects; D014711:Vertebral Artery / Q000187:drug effects*
D010451:Peptide PHI; D012701:Serotonin; D014660:Vasoactive Intestinal Peptide; D001285:Atropine; D006632:Histamine; D011433:Propranolol; D002049:Burimamide; D009638:Norepinephrine