[A study on treatment of hyperuricemia--effects and kinetics of allopurinol and oxipurinol].
In order to study the effects and pharmacokinetics of allopurinol (hereafter abbreviated to allo.) and oxipurinol (hereafter abbreviated to oxi.) six normal human subjects were given a single oral dose of either allo. (300mg) or oxi. (600mg), followed by serial determinations of serum and urinary levels of allo., oxi., uric acid, hypoxanthine (hereafter abbreviated to hx.) and xanthine (hereafter abbreviated x.) over a six-hour period. With a dose of 300mg of allo. or 600mg of oxi., the patterns of serum uric acid were similar. When 300mg of allo. was given, however, a reduction in the serum uric acid level occurred earlier. Additionally, it was found that urinary excretion of oxi. generally paralleled the plasma concentration. Allo. administration resulted in rises in plasma concentration of x., and urinary excretion of x. and hx. Oxi. administration, on the other hand, did not cause significant changes in the plasma content of x. or urinary excretory volume of hx. Only a slight increase was noted in the amount of x. excreted in the urine. When allo. was compared against oxi., pharmacokinetics of oxypurines, especially x. were found to differ markedly. The results suggested that differences in the reaction sites, varied intra- and extra-cellular distributions of allo. and oxi., and different effects on purine biosynthesis contribute to the aforementioned discrepancies.
Hosoya
T
T
Second Department of Medicine, Jikei University School of Medicine, Tokyo.
Ichida
K
K
Tabe
A
A
Sakai
O
O
D000328:Adult; D000493:Allopurinol / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000097:blood / Q000652:urine; D008297:Male; D010117:Oxypurinol / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D012016:Reference Values; D014527:Uric Acid / Q000097:blood / Q000652:urine; D019820:Xanthine; D014970:Xanthines / Q000097:blood / Q000652:urine
D007042:Hypoxanthines; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D000493:Allopurinol; D010117:Oxypurinol