title: Deuterium-labelled p-tyramine challenge test and phenolsulfotransferase activity in depressed patients--failure to replicate decreased p-tyramine conjugation in depression.
abstract: 1. Depressed and normal subjects were challenged with deuterium-labelled p-tyramine and urine was collected for 3 h. 2. Urinary excretion of conjugated p-tyramine was not significantly different between normal, melancholic and non-melancholic depressed subjects. 3. Platelet phenolsulfotransferase activity to p-tyramine (p less than 0.05) and to phenol (p less than 0.005) were significantly lower in the depressed patients.
authors.affiliation: Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon.
authors.forename: B A
authors.initials: BA
authors.lastname: Davis
authors.forename: A A
authors.initials: AA
authors.lastname: Boulton
authors.forename: P H
authors.initials: PH
authors.lastname: Yu
authors.forename: D A
authors.initials: DA
authors.lastname: Durden
authors.forename: R C
authors.initials: RC
authors.lastname: Bowen
authors.forename: D L
authors.initials: DL
authors.lastname: Keegan
authors.forename: S
authors.initials: S
authors.lastname: Blackshaw
authors.forename: C
authors.initials: C
authors.lastname: D'Arcy
authors.forename: A J
authors.initials: AJ
authors.lastname: Remillard
authors.forename: N
authors.initials: N
authors.lastname: Dayal
mesh_terms: D000639:Amitriptyline / Q000494:pharmacology; D015239:Arylsulfotransferase / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D003866:Depressive Disorder / Q000175:diagnosis / Q000201:enzymology* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011897:Random Allocation; D014439:Tyramine / Q000378:metabolism
chemical_list: D005473:Fluoxetine; D000639:Amitriptyline; D015239:Arylsulfotransferase; D014439:Tyramine