Transient elevation of serum lactic dehydrogenase following autologous bone marrow transplantation.
Transient elevated levels of serum lactic dehydrogenase (LDH) were reported immediately following autologous bone marrow transplantation consecutively in 15 patients. Isoenzyme 2 was the predominant elevated isoenzyme of LDH, suggesting that the source of LDH is either hemolysis of RBCs, which occurs during freezing and thawing of bone marrow in the bags and in vivo following infusion of residual dimethyl sulfoxide.
Gomez
S
S
Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
Nagler
A
A
Naparstek
E
E
Slavin
S
S
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005260:Female; D006402:Hematologic Diseases / Q000601:surgery; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D014182:Transplantation, Autologous
D007770:L-Lactate Dehydrogenase; D004121:Dimethyl Sulfoxide