title: Effects of antihypertensive factor from erythrocyte of spontaneously hypertensive rats on the blood pressure and Ca2+ influx of arterial smooth muscle in rats.
abstract: The effects of a partially purified antihypertensive factor (AHF) from erythrocytes of spontaneously hypertensive rats (SHR) on the blood pressure (BP) and Ca2+ influx of vascular smooth muscle (VSM) in rats were studied. The results indicated that AHF could produce a marked prolonged depressor effect and significantly inhibit the Ca2+ influx dose-dependently on both SHR and renal hypertensive rat (RHR) either in acute or in chronic experiments, but not on normotensive rats. It suggested that the inhibition of Ca2+ influx might be one of the important mechanisms for AHF as an endogenous depressor substance.
authors.affiliation: Department of Physiology, Chinese Academy of Medical Sciences, Beijing.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Wen
authors.forename: M Q
authors.initials: MQ
authors.lastname: Chen
authors.forename: H P
authors.initials: HP
authors.lastname: Jia
authors.forename: G Y
authors.initials: GY
authors.lastname: Wu
authors.forename: L P
authors.initials: LP
authors.lastname: Zhou
authors.forename: T
authors.initials: T
authors.lastname: Lu
authors.forename: S F
authors.initials: SF
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001011:Aorta; D001685:Biological Factors / Q000494:pharmacology*; D001693:Biological Transport, Active; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism*; D004912:Erythrocytes / Q000737:chemistry; D008297:Male; D008638:Mesenteric Arteries; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY
chemical_list: D001685:Biological Factors; D002118:Calcium