Sixth mycelial fraction acetone (6-MFA), an interferon inducer modulates acrylamide neurotoxicity.
A single i.p. administration of an immunomodulatory agent 6-MFA (a biological response modifier and antiviral agent of fungal origin, 10 mg/100g b.wt.), on 5th day of repeated acrylamide (ACR, 50 mg/kg b.wt.) treatment significantly protected rats against its specific neurotoxic effects. Corpus striatal 3H-spiperone binding elevated (24%) while glutathione-S-transferase (GST) activity decreased (33%) in ACR group but values were markedly restored in 6-MFA alone and co-exposed group. Development of hind limb paralysis was also protected by 6-MFA. Results warrant the possible involvement of immune mechanisms and certain other factors such as lymphokines, hormones and microglia at the target site, which in turn facilitate the repair mechanism suggesting a therapeutic role of 6-MFA in clinical cases of toxic neuropathies in future.
Husain
R
R
Industrial Toxicology Research Centre, Lucknow, India.
Khanna
V K
VK
Zaidi
S I
SI
Mall
S A
SA
Husain
M M
MM
Gupta
B M
BM
Seth
P K
PK
D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects; D005656:Fungal Proteins / Q000494:pharmacology*; D005982:Glutathione Transferase / Q000378:metabolism; D007369:Interferon Inducers / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010243:Paralysis / Q000139:chemically induced; D011485:Protein Binding; D051381:Rats; D013134:Spiperone / Q000378:metabolism
D000178:Acrylamides; D005656:Fungal Proteins; D007369:Interferon Inducers; C008524:MFA 6 extract, Aspergillus ochraceus; D013134:Spiperone; D005982:Glutathione Transferase