[The effect of inhalation of sevoflurane for an hour on the liver of beagles].
The effect of sevoflurane in comparison with that of enflurane and halothane, each at 1.8 MAC, on the liver was examined after inhalation exposure to beagles under controlled respiration for 1 hr. No abnormalities were observed in general conditions in the animals exposed to any of these anesthetics. Recovery time to spontaneous respiration after the end of anesthesia was similar for each group, but the awakening was quickest in sevoflurane exposed group. Blood pressure dropped immediately after the initiation of exposure in each group, but it recovered quickly to preexposure levels after the end of the exposure. Minor and reversible elevations in the values of GOT, GPT, LDH and bilirubin were noted without the organic change of the liver in beagles after the inhalation exposure to 1.8 MAC of each anesthetic. Since similar changes were observed in beagles exposed to enflurane or halothane, we conclude that no change in the liver specifically associated with sevoflurane was found under these experimental conditions.
Nagata
R
R
Shin Nippon Biomedical Laboratories, Ltd., Kagoshima.
Sameshima
H
H
Komaki
T
T
Tanaka
K
K
Koja
T
T
Okasaki
K
K
Tamura
T
T
Inoue
S
S
D000769:Anesthesia, Inhalation; D000818:Animals; D004285:Dogs; D004737:Enflurane / Q000494:pharmacology; D004987:Ethers / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008738:Methyl Ethers; D000077149:Sevoflurane
D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D004737:Enflurane; D006221:Halothane