The interactions of alpha-thalassemia with hemoglobinopathies.
Because of their high prevalence throughout the world, alpha-thalassemia and hemoglobinopathies often occur in the same individual. Southern blot hybridization analysis of the alpha-globin gene cluster permits the detection of the common deletion alpha-thalassemias and the definition of the phenotypes affiliated with the interactions of alpha-thalassemia and hemoglobinopathies. Important insights into the pathophysiology of Hb SS have been gained, and the nature of the perturbation of heterozygous hemoglobinopathies by alpha-thalassemia has been established.
Steinberg
M H
MH
Department of Veterans Affairs Medical Center, Jackson, Mississippi.
D000755:Anemia, Sickle Cell / Q000150:complications; D000818:Animals; D002872:Chromosome Deletion; D005914:Globins / Q000235:genetics*; D006453:Hemoglobinopathies / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D012805:Sickle Cell Trait / Q000150:complications; D013789:Thalassemia / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology
D005914:Globins