title: Effect of magnesium ions on the inhibition of S-adenosylmethionine decarboxylase from Escherichia coli by [2-(amino-oxy)ethyl](5'-deoxyadenosin-5'-yl)(methyl)sulphonium .
abstract: [2-(Amino-oxy)ethyl](5'-deoxyadenosin-5'-yl)(methyl)sulphonium+ ++, the amino-oxy analogue of decarboxylated S-adenosylmethionine, is a potent irreversible inhibitor of Escherichia coli S-adenosylmethionine decarboxylase [Khomutov, Zavalova, Syrku, Artamonova & Khomutov (1983) Bioorg. Khim. 9, 130-131; Artamonova, Zavalova, Khomutov & Khomutov (1986) Bioorg. Khim. 12, 206-212]. We have shown that Mg2+ ions are required for the irreversible inhibition of the decarboxylase, and that S-adenosylmethionine protects against this inhibition.
authors.affiliation: Department of Biochemistry, University of Cambridge, U.K.
authors.forename: E L
authors.initials: EL
authors.lastname: Weitkamp
authors.forename: H B
authors.initials: HB
authors.lastname: Dixon
authors.forename: A R
authors.initials: AR
authors.lastname: Khomutov
authors.forename: R M
authors.initials: RM
authors.lastname: Khomutov
mesh_terms: D012437:Adenosylmethionine Decarboxylase / Q000037:antagonists & inhibitors*; D003839:Deoxyadenosines / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D008274:Magnesium / Q000494:pharmacology*; D011485:Protein Binding; D012436:S-Adenosylmethionine / Q000378:metabolism
chemical_list: D003839:Deoxyadenosines; D012436:S-Adenosylmethionine; C042768:S-(5'-deoxyadenosyl-5')-S-methylthioethylhydroxylamine; D012437:Adenosylmethionine Decarboxylase; D008274:Magnesium