[Immunosuppression induced by respiratory viruses (influenza virus, adenovirus) in mice].
The influence of respiratory viruses (adenovirus, influenza virus) on humoral immune response to heterologous T-dependent and T-independent antigens was studied. It was shown that inoculation of mice by the influenza virus (A/PR8/34-A/PR/8) 3 days before sheep red blood cells administration led to the inhibition of antibody forming cell (AFC) and immunoglobulin, forming cell (IFC) increase on 69% and 59% respectively. Adenovirus type 6 induced the similar suppression of AFC and IFC formation. Thus, viruses induced immuno-suppression, which was polyclonal. It was also shown that virus of one strain (type) could inhibit immune response to another strain (type) of virus. The immune response to T-independent antigen was not suppressed. The virus-induced immunosuppression was dependent on: 1) the infectivity of respiratory viruses, 2) the route of virus and heterologous antigen injection, and 3) the interval between the viruses and antigen inoculation.
Sidorova
E V
EV
Agadzhanian
M G
MG
Mazhul'
L A
LA
Biladi
I
I
Bakai
M
M
Berenchi
K
K
D000256:Adenoviridae / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000956:Antigens, Viral / Q000276:immunology; D005260:Female; D007165:Immunosuppression Therapy; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C
D000914:Antibodies, Viral; D000956:Antigens, Viral
Ugnetenie respiratornymi virusami (gripp, adenovirus) immunogo otveta u mysheĭ.