Bivariate genetic analysis of left ventricular mass and weight in pubertal twins (the Medical College of Virginia twin study).
Left ventricular (LV) hypertrophy in adults is a recognized risk factor for the subsequent development of cardiovascular morbidity. To make informed preventive health decisions it is important to understand the interaction of genes and environment on LV mass. In both children and adults, weight is a strong correlate of LV mass. We hypothesized that genetic influences common to both of these variables could in part explain the strong relation between weight and LV mass in children. In a population of 341 twins (11 years old), these questions were asked: (1) How much of the total variance of LV mass is under genetic control? (2) After accounting for weight and weight adjusted for sexual maturity, how much of the remaining variance is genetic? (3) Of the total genetic variance, what proportion is specific for LV mass and what proportion is common to both weight and LV mass? (4) How much of the correlation between these 2 variables is explained by genes common to both LV mass and weight? Univariate genetic analyses documented that genes operating at different magnitudes in boys (63%) and girls (71%) explain a significant proportion of the variance of LV mass. After removing the effect of weight and sexual maturity by regression methods, genes remain an important influence. Bivariate genetic analyses confirmed that genes common to LV mass and weight significantly influence the covariation of these variables and that greater than 90% of the correlation of LV mass and weight is due to common genes.
Verhaaren
H A
HA
Division of Pediatric Cardiology, Children's Medical Center, Medical College of Virginia, Richmond 23298-0026.
Schieken
R M
RM
Mosteller
M
M
Hewitt
J K
JK
Eaves
L J
LJ
Nance
W E
WE
D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics*; D002648:Child; D004452:Echocardiography; D004777:Environment; D005260:Female; D014644:Genetic Variation; D006352:Heart Ventricles / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D011627:Puberty; D015203:Reproducibility of Results; D012737:Sex Factors; D013223:Statistics as Topic; D014427:Twins / Q000235:genetics*; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics; D014768:Virginia; D015053:Zygote