title: Modulation of the intestinal flora of mice by treatment with aztreonam and tigemonam.
abstract: Oral and parenteral administration of aztreonam and oral administration of tigemonam to conventional mice caused a decrease in the number of aerobic gram-negative rods in the feces. Oral treatment with high doses of aztreonam (greater than or equal to 25 mg/kg/day) and tigemonam (100 mg/kg/day) adversely influenced colonization resistance, whereas oral treatment with lower doses of the monobactams or parenteral treatment with aztreonam did not.
authors.affiliation: Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
authors.forename: M L
authors.initials: ML
authors.lastname: van Ogtrop
authors.forename: H F
authors.initials: HF
authors.lastname: Guiot
authors.forename: H
authors.initials: H
authors.lastname: Mattie
authors.forename: E
authors.initials: E
authors.lastname: van Strijen
authors.forename: B R
authors.initials: BR
authors.lastname: Sekh
authors.forename: R
authors.initials: R
authors.lastname: van Furth
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001398:Aztreonam / Q000008:administration & dosage / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004352:Drug Resistance, Microbial; D005243:Feces / Q000382:microbiology; D005260:Female; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects; D007279:Injections, Subcutaneous; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*; D051379:Mice; D008997:Monobactams / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D008997:Monobactams; C052020:tigemonam; D001398:Aztreonam