Effect of hyperglycemia on acetylcholinesterase and catecholamine levels in rat brain and heart.
The effect of hyperglycemia due to experimental diabetes induced in rats, causes a decrease in the activity of Acetylcholinesterase in brain regions and heart; changes in the heart being more significant than the brain. Insulin administration reversed this effect in both the hear and the brain. Significant increase in the levels of catecholamines were also found in the brain regions in diabetes, which was reversed by insulin. The decreased activity of acetylcholinesterase observed in diabetes may be due to an early impaired glucose oxidation and glucose transport as a result of lack of insulin, which causes specific alterations in neurotransmitter levels, thereby effecting blood brain barrier transport, thus causing brain dysfunction.
Dash
N K
NK
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Azam
M
M
Gupta
G
G
Baquer
N Z
NZ
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D001933:Brain Stem / Q000201:enzymology; D002395:Catecholamines / Q000378:metabolism; D002458:Cell Fractionation; D002531:Cerebellum / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000201:enzymology; D006943:Hyperglycemia / Q000139:chemically induced / Q000201:enzymology*; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism
D002395:Catecholamines; D007328:Insulin; D012701:Serotonin; D000110:Acetylcholinesterase