title: [Studies on the clinical evaluation of tissue polypeptide antigen (TPA) levels in the peripheral and draining venous blood of gastric cancer patients].
abstract: Correlation with TPA levels of peripheral (p) and draining (d) venous blood, and 11 histopathologic variables, postoperative recurrence and survival was examined in 40 patients with gastric cancer. Elevation of d-TPA levels was correlated with tumor location, size, macroscopic type, invasive layer of gastric wall, venous invasion, node and liver metastases and stage classification, though elevation of p-TPA levels was correlated only with liver metastasis. No significant difference of p-TPA levels was found between the patients with and without cancer recurrence. d-TPA levels (mean 1318U/l and positive rate greater than 726U/l of mean +/- 2SD in patients with benign diseases, 59%) of the former were significantly higher than those (518U/l and 15%) of the latter. Correlation between d-TPA levels and recurrent sites was not found. Most of the patients with hematogenous recurrence showed the elevated p-TPA levels, but none of the patients with local recurrence revealed the elevation. Survival in both patients with non-elevated p- and d-TPA levels was significantly better than in patients with the elevated levels. These results suggest d-TPA levels are more closely correlated with histopathologic variables and postoperative recurrent rates than p-TPA levels, preoperative determination of p- and d-TPA levels is useful for the estimation of the postoperative prognosis and patients with elevated p- and d-TPA levels should be clinically treated as patients with high recurrence and poor prognosis.
authors.affiliation: First Department of Surgery, Kobe University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Funasaka
authors.forename: Y
authors.initials: Y
authors.lastname: Tabuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000097:blood*; D016009:Chi-Square Distribution; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D010455:Peptides / Q000378:metabolism*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D019396:Tissue Polypeptide Antigen; D014680:Veins
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D010455:Peptides; D019396:Tissue Polypeptide Antigen