title: Mizuo phenomenon in X-linked retinoschisis. Pathogenesis of the Mizuo phenomenon.
abstract: Four unrelated males with X-linked retinoschisis and a golden fundus reflex had Mizuo-Nakamura phenomenon, which, to our knowledge, has been described only in Oguchi's disease and X-linked cone dystrophy. These findings, together with experimental observations and data from the literature, led us to hypothesize that the Mizuo-Nakamura phenomenon is caused by an excess of extracellular potassium in the retina as a result of a decreased potassium scavenging capacity of retinal Müller cells.
authors.affiliation: Institute of Ophthalmology, Erasmus University, Rotterdam, The Netherlands.
authors.forename: P T
authors.initials: PT
authors.lastname: de Jong
authors.forename: E
authors.initials: E
authors.lastname: Zrenner
authors.forename: G J
authors.initials: GJ
authors.lastname: van Meel
authors.forename: J E
authors.initials: JE
authors.lastname: Keunen
authors.forename: D
authors.initials: D
authors.lastname: van Norren
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D003116:Color; D003623:Dark Adaptation; D005654:Fundus Oculi; D008040:Genetic Linkage; D006801:Humans; D008027:Light; D008297:Male; D008954:Models, Biological; D010781:Photography; D012160:Retina / Q000473:pathology*; D012167:Retinal Perforations / Q000235:genetics* / Q000473:pathology; D014960:X Chromosome