[Non-dietary, non-pharmacological treatment of severe hypercholesterolemia].
Non-dietary, non-pharmacological reduction of cholesterol in patients with severe hypercholesterolemia can be obtained by partial ileal by-pass, portacaval shunt operation or liver transplantation. A non-surgical method is apheresis, by which low density and very low density lipoproteins are removed from blood in an extracorporal circulation system. Apheresis methods include plasmapheresis, immunoadsorption, chemical affinity and Double Membrane Filtration. Treatment of a 30 year old man with severe familial hypercholesterolemia and ischaemic heart disease, by LDL-apheresis, resulted in an average decline in serum-cholesterol of 35%. LDL-apheresis is indicated in the treatment of this type of patient and in homozygous familial hypercholesterolemia.
Hansen
P S
PS
Arhus Amtssygehus, medicinsk-kardiologisk afdeling I.
Sølling
J
J
Knudsen
T E
TE
Faergeman
O
O
D000328:Adult; D008078:Cholesterol, LDL / Q000097:blood*; D005112:Extracorporeal Circulation / Q000379:methods; D005374:Filtration / Q000379:methods; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000601:surgery / Q000628:therapy*; D007082:Ileum / Q000601:surgery; D007163:Immunosorbent Techniques; D016031:Liver Transplantation / Q000379:methods; D008297:Male; D010956:Plasmapheresis / Q000379:methods; D011167:Portacaval Shunt, Surgical / Q000379:methods
D008078:Cholesterol, LDL
Ikke-diaetetisk, ikke-farmakologisk behandling af svaer hyperkolesterolaemi.