title: [The effect of N-acetylaspartic acid on the processes of memory and learning in rats].
abstract: The effects of a neurospecific substance N-acetyl-aspartic acid on memory and learning processes were investigated after intraperitoneal and oral administrations in rats. N-acetyl-aspartic acid was shown to restore the passive avoidance reaction in electroshock and scopolamine amnesias as well as in natural extinction. Chronic injections of N-acetyl-aspartic acid improved the learning in water maze but exerted no effect on the acquisition and retention of the active avoidance reaction in the shuttle box.
authors.forename: G V
authors.initials: GV
authors.lastname: Kovalev
authors.forename: V A
authors.initials: VA
authors.lastname: Sazhin
authors.forename: A V
authors.initials: AV
authors.lastname: Ianitskaia
mesh_terms: D000647:Amnesia / Q000188:drug therapy / Q000209:etiology; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D002491:Central Nervous System Agents / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004644:Emotions / Q000187:drug effects; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D009949:Orientation / Q000187:drug effects; D051381:Rats
chemical_list: D002491:Central Nervous System Agents; D001224:Aspartic Acid; C000179:N-acetylaspartate
vernacular_title: Vliianie N-atsetilasparaginovoĭ kisloty na protsessy pamiati i obucheniia u krys.