title: Reactions of cells at implant surfaces.
abstract: The surface of implants is an important parameter in host-implant integration. Several strategies can be used to obtain integration, such as the application of grooves or pores at the implant surface. Most of these surface alterations, however, will lead to an increase of total implant surface area which might influence the inflammatory response to an implant. As far as integration with bone is concerned several biomaterials have been successful in mimicking this material, by having similar crystals at their surface (calcium phosphate ceramics) or by containing a certain amount of calcium and phosphorus. Polyactive, a poly(ethylene oxide)-poly(butylene terephthalate) segmented copolymer, also possesses favourable integration properties with bone, but initially lacks calcium and phosphorus. It is proposed that the application of hydrogels as biomaterial may add a new dimension to integration capacity.
authors.affiliation: Laboratory for Otobiology & Biocompatibility, ENT Department, Biomaterials Research Group, University Hospital, Leiden, The Netherlands.
authors.forename: C A
authors.initials: CA
authors.lastname: van Blitterswijk
authors.forename: D
authors.initials: D
authors.lastname: Bakker
authors.forename: S C
authors.initials: SC
authors.lastname: Hesseling
authors.forename: H K
authors.initials: HK
authors.lastname: Koerten
mesh_terms: D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials; D002118:Calcium; D005549:Foreign-Body Reaction / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008854:Microscopy, Electron; D016348:Osseointegration; D019736:Prostheses and Implants; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D002118:Calcium