title: In vitro evaluation of an implantable left ventricular assist device.
abstract: The development of implantable left ventricular assist devices (LVADs) has almost reached the stage of providing permanent circulatory support in patients who are unsuitable for, or denied, the transplant option. As part of our ongoing haemodynamic evaluation of the Thermo Cardiosystems Inc. (Boston, USA) Mark 14 pneumatic LVAD, pressure-volume loops have been produced from in vitro studies using a modified National Heart Lung and Blood Institute (NHLBI, USA) mock circulatory loop. These studies have demonstrated that during certain phases of the pump cycle non-physiologically high and low pressures are generated within the LVAD. Such abnormal pressures may damage either the bioprosthetic valves in the LVAD or the native heart, and may have adverse effects on cardiovascular control mechanisms.
authors.affiliation: Department of Anaesthesia and Cardiothoracic Surgery, London Hospital, Whitechapel, UK.
authors.forename: P S
authors.initials: PS
authors.lastname: Withington
authors.forename: T R
authors.initials: TR
authors.lastname: Graham
authors.forename: R J
authors.initials: RJ
authors.lastname: Meikle
authors.forename: A
authors.initials: A
authors.lastname: Allan
authors.forename: M T
authors.initials: MT
authors.lastname: Marrinan
authors.forename: C T
authors.initials: CT
authors.lastname: Lewis
mesh_terms: D005069:Evaluation Studies as Topic; D006353:Heart-Assist Devices; D011312:Pressure; D019736:Prostheses and Implants; D011474:Prosthesis Design