Xanthine-containing urinary calculi in dogs given allopurinol.
Clinical features and laboratory findings were evaluated in 10 dogs that formed xanthine-containing urinary calculi during the period that they were given allopurinol (9 to 38 mg/kg of body weight/d). Duration of allopurinol treatment was 5 weeks to 6 years. Of the 10 dogs, 9 (all Dalmatians) had formed uric acid-containing calculi at least once before allopurinol treatment was initiated. It was not possible to recognize xanthine as a crystalline component of the calculi by use of a chemical colorimetric method or by polarized light microscopy. We concluded that the best diagnostic method for recognition of xanthine-containing calculi was high-pressure liquid chromatography because it is quantitative, sensitive, and accurate, and can be conducted on a small amount (1 to 2 mg) of crystalline material.
Ling
G V
GV
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
Ruby
A L
AL
Harrold
D R
DR
Johnson
D L
DL
D000493:Allopurinol / Q000009:adverse effects* / Q000627:therapeutic use; D000818:Animals; D001947:Breeding; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D008297:Male; D014545:Urinary Calculi / Q000139:chemically induced / Q000737:chemistry* / Q000517:prevention & control; D014961:X-Ray Diffraction; D019820:Xanthine; D014970:Xanthines / Q000032:analysis* / Q000652:urine
D014970:Xanthines; D019820:Xanthine; D000493:Allopurinol