title: Trials and tribulations of multicenter studies. Lessons learned from the experiences of the Southwest Pediatric Nephrology Study Group (SPNSG).
abstract: Multicenter studies in Pediatric Nephrology have been acknowledged in recent years as an important mechanism for studying renal disease in children. The purpose of this review is to describe some of the experiences of the Southwest Pediatric Nephrology Study Group (SPNSG) in order to assist others in developing their own multicenter studies. The importance of protocol development, including adequate attention to study design, data management, and data analysis, is emphasized. Mechanisms for facilitating the frequency and productivity of study group meetings that are so essential for the success of multicenter studies, are described in some detail. The need and some of the methods for achieving ongoing collaboration within a climate of critical peer review are also discussed. Controversial issues such as authorship and the question of institutional credit for involvement in multicenter studies are discussed in brief. Finally, some of the features of the SPNSG that have permitted us to maintain a relatively high rate of productivity are described. The two most important of these, ongoing commitment to the group and willingness to collaborate across differences of opinion, are stressed throughout the review.
authors.affiliation: Southwest Pediatric Nephrology Study Group, Baylor University Medical Center, Dallas, Texas.
authors.forename: R J
authors.initials: RJ
authors.lastname: Hogg
mesh_terms: D001319:Authorship; D002985:Clinical Protocols / Q000592:standards*; D002986:Clinical Trials as Topic; D006801:Humans; D015337:Multicenter Studies as Topic / Q000592:standards*; D009398:Nephrology; D010372:Pediatrics; D011643:Publishing; D012107:Research Design