title: Skull, patella and thigh cryptococcosis after a crashing injury of the temporal bone.
abstract: An unusual case of triple location (skull, patella and thigh) Cryptococcus neoformans is described. The peculiarity of the case is based on the probability of direct post-traumatic bone inoculation, subsequent seeding from skull to patella, thigh and cerebral spinal fluid (CSF), patella involvement, lack of evidence of lung involvement and lack of predisposing underlying disease. The response to surgery and a combination of amphotericin B and 5-flucytosine administration was favorable without relapse at follow-up after 7-year discontinuation of therapy.
authors.affiliation: Orthopedics Dept. Laiko General Hospital, Athens, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Dounis
authors.forename: H
authors.initials: H
authors.lastname: Giamarellou
authors.forename: T
authors.initials: T
authors.lastname: Peppas
authors.forename: P
authors.initials: P
authors.lastname: Sfikakis
mesh_terms: D001847:Bone Diseases / Q000175:diagnosis / Q000382:microbiology; D003453:Cryptococcosis / Q000175:diagnosis / Q000382:microbiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010329:Patella; D012886:Skull; D013701:Temporal Bone / Q000293:injuries*; D013848:Thigh