Improved physical performance after treatment of renal anemia with recombinant human erythropoietin.
The physical performance of 12 anemic patients on renal dialysis was investigated following treatment of renal anemia with recombinant human erythropoietin (rhEPO; 40-120 U/kg, 3 times a week). Exercise intensity at a heart rate of 130 beats/min (PWC130) on a bicycle ergometer was assessed before rhEPO treatment, after reaching the target hematocrit (73 +/- 18 days), and in the maintenance phase (211 +/- 53 days). Hemoglobin concentrations measured at these time points were 7.3 +/- 1.2, 11.9 +/- 1.5, and 12.1 +/- 1.4 g/dl, respectively. PWC130 rose from 77 +/- 27 to 104 +/- 37 and 104 +/- 51 W, respectively. Aerobic threshold (i.e. blood lactic acid concentration of 2 mmol/l) shifted to higher workloads indicating improved muscle oxygen supply.
Braumann
K M
KM
Abteilung Sport- und Arbeitsphysiologie, Medizinische Hochschule Hannover, BRD.
Nonnast-Daniel
B
B
Böning
D
D
Böcker
A
A
Frei
U
U
D000328:Adult; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D001794:Blood Pressure; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D006435:Renal Dialysis
D006454:Hemoglobins; D007773:Lactates; D004921:Erythropoietin; D019344:Lactic Acid