Genetic diversity among toxigenic and nontoxigenic Vibrio cholerae O1 isolated from the Western Hemisphere.
Multilocus enzyme electrophoresis was used to examine genetic relationships among and between toxigenic and non-toxigenic isolates of Vibrio cholerae O1 obtained from patients and the environment in the US Gulf Coast and surrounding areas. A total of 23 toxigenic and 23 non-toxigenic strains were examined. All the toxigenic and 7 of the non-toxigenic strains had the same alleles at 16 enzyme loci, whereas the balance of the nontoxigenic strains had 9 distinct combinations of alleles. This study suggests that all of the toxigenic strains belong to a single clone, and that while some of the non-toxigenic isolates were related, most were of diverse origin.
Chen
F
F
Laboratory for Microbial and Biochemical Sciences, Georgia State University, Atlanta 30303.
Evins
G M
GM
Cook
W L
WL
Almeida
R
R
Hargrett-Bean
N
N
Wachsmuth
K
K
D000483:Alleles; D001938:Brazil; D002771:Cholera / Q000382:microbiology*; D002772:Cholera Toxin / Q000096:biosynthesis; D016000:Cluster Analysis; D004592:Electrophoresis, Starch Gel; D004783:Environmental Microbiology; D004798:Enzymes / Q000032:analysis / Q000235:genetics; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008800:Mexico; D010568:Peru; D014481:United States; D014734:Vibrio cholerae / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism
D004798:Enzymes; D002772:Cholera Toxin