Plasma uric acid in patients receiving anticonvulsant monotherapy.
In newly diagnosed adult patients with epilepsy followed prospectively on monotherapy, carbamazepine and phenytoin were associated with a fall in plasma uric acid, but sodium valproate and phenobarbitone were associated with a rise in plasma uric acid. The mechanisms and significance of these findings are discussed.
Ring
H A
HA
Department of Neurology, King's College Hospital, London, U.K.
Heller
A J
AJ
Marshall
W J
WJ
Johnson
A L
AL
Reynolds
E H
EH
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D011446:Prospective Studies; D014527:Uric Acid / Q000097:blood*; D014635:Valproic Acid / Q000627:therapeutic use
D000927:Anticonvulsants; D014527:Uric Acid; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D010634:Phenobarbital