[Effect of tetrandrine and verapamil on left ventricular diastolic and systolic function in essential hypertension].
By using apexcardiography and echocardiography, the diastolic and systolic function of 34 hypertensive patients were studied. The results indicated that left ventricular (LV) hypertrophy is one of the important factors in impairing LV diastolic function in essential hypertension. By using self-control method, Verapamil(V) was injected intravenously. Relative A wave to total diastolic amplitude (A/D), total apexcardiographic relaxation time index (TARTI), diastolic amplitude time index (DATI) and PEP/LVET were measured. After 5 half-lives of V, intravenous Tetrandrine (T) was given, all the measurements were repeated in the same way. The data revealed that A/D, TRATI and DATI improved significantly after intravenous T and V as well, yet PEP/LVET showed no significant change. It, therefore, seems clear that both T and V could induce a significant improvement in LV diastolic function without any apparent adverse influence on systolic function.
Zeng
B
B
Institute of Cardiovascular Diseases, Tongji Medical University, Wuhan.
Dai
G Z
GZ
D000328:Adult; D000368:Aged; D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D000470:Alkaloids; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers; C009438:tetrandrine; D014700:Verapamil