Some electrochemical characteristics of synthetic analogs of nucleic acid components. IV. 5-Cyano-, 5-carboxy- and 5-azaderivatives, and the effect of this substitution on potential carcinogenicity.
The relation between polarographic reduction, values of half-wave potentials, and the parameter of potential carcinogenicity (tg alpha) was studied in a series of synthetic analogs of natural nucleic acid components modified by different substituents at position 5 of the base. The series included pyrimidine nucleobases (5-cyanouracil, 5-carboxycytosine, 5-azacytosine), ribofuranosyl nucleosides (5-cyanouridine, 5-carboxycytidine, 5-azacytidine) as well as 2'-deoxy-5-azacytidine and 5-carboxy-1-beta-D-arabinosylcytosine. No direct correlation was found between the reducibility of the studied compounds and the parameter of potential carcinogenicity tg alpha since event a slight alteration in the structure of these molecules markedly affected the properties of these compounds.
Vachálková
A
A
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Novotný
L
L
D001372:Aza Compounds / Q000737:chemistry*; D003562:Cytidine / Q000031:analogs & derivatives; D003596:Cytosine / Q000031:analogs & derivatives; D011048:Polarography; D008063:Thioctic Acid / Q000494:pharmacology; D014498:Uracil / Q000031:analogs & derivatives; D014529:Uridine / Q000031:analogs & derivatives
D001372:Aza Compounds; D014498:Uracil; D003562:Cytidine; D008063:Thioctic Acid; D003596:Cytosine; D014529:Uridine