Chronic oral treatment with diltiazem or verapamil decreases isolation-induced activity impairment in elevated plus maze.
Adult male Wistar rats were either socially isolated or group-housed for 6 weeks and then tested in an elevated plus maze. During isolation the rats received either water or two concentrations of the calcium channel inhibitors, diltiazem or verapamil, in drinking solutions (approximately 5 and 10 mg/kg daily). Isolated rats showed a significantly lower total number of arm entries, a lower percentage of open arm entries and negligible time spent therein than did group-housed animals. Verapamil, in the higher dose, prevented that effect of isolation. Treatment with diltiazem brought about a similar tendency, though the effect did not reach statistical significance. Chronic treatment of group-housed rats with either drug failed to influence their behavior in the plus maze. We conclude that certain calcium channel inhibitors may decrease the behavioral deficit in the elevated plus maze that follows chronic social isolation.
Jankowska
E
E
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland.
Pucilowski
O
O
Kostowski
W
W
D000818:Animals; D001143:Arousal / Q000187:drug effects; D004110:Diltiazem / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005239:Fear / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009949:Orientation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012934:Social Isolation; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D004110:Diltiazem