[Plasma prostacyclin and thromboxane concentration in healthy children and in offspring of parents suffering from myocardial infarct].
6-keto-prostaglandin F1a and thromboxane B2 were determined by radioimmunoassay in 135 healthy children, as a control group, and in 125 offsprings of parents suffering from premature coronary artery disease. Plasma prostacyclin concentration had decreased in children with a positive family history of coronary artery disease. It was demonstrated a strong reduction of thromboxane level in boys from age 11 in endangered group while the thromboxane/prostacyclin ratio did not differ from the control. It was supposed that in adolescent sons of parents who have had an acute myocardial infarction before the age of 45, a compensatory mechanism exists to protect them from disturbances in regulation of the balance between prostacyclin and thromboxane.
Mihai
K
K
Bács-Kiskun megyei "Hollós József" Kórház-Rendelöintézet, Kecskemét, I. Belgyógyászati Osztály.
Petö
J
J
Kolthay
E
E
Makáry
A
A
Timár
S
S
Lusztig
G
G
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics; D011460:Prostaglandins F / Q000097:blood*; D011863:Radioimmunoassay; D012737:Sex Factors; D013931:Thromboxanes / Q000097:blood*
D011460:Prostaglandins F; D013931:Thromboxanes; D011464:Epoprostenol
Plazma prosztaciklin és tromboxán koncentráció egészséges gyermekeken és fiatalkori myocardialis infarctusban megbetegedett szülök utódaiban.