[Synthesis and cytostatic actions of 10- and 11-nitronoracronycins, molecular variations of cytostatically active acronycine].
The syntheses of 11- and 10-nitronoracronycine (10 and 11) from 1,3-dihydroxy-10-methyl-5-nitroacridinone (7) or 1,3-dihydroxy-10-methyl-6-nitroacridinone (8), respectively, and 2-chloro-2-methyl-3-butyne are reported. In screening tests with the transplantation tumor leukemia P 388 10, 11, 7 and 1,3-dimethoxy-10-methyl-6-nitroacridinone showed cytotoxicity. 8 and 1,3-dimethoxy-10-methyl-nitroacridinone (5) proved to be inactive.
Reisch
J
J
Institut für Pharmazeutische Chemie, Westfälischen Wilhelms-Universität, Münster.
Dziemba
P
P
D000175:Acronine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy
D000970:Antineoplastic Agents; C069900:11-nitronoracronycin; C069899:10-nitronoracronycin; D000175:Acronine
Synthese und cytostatische Wirkungen des 10- und 11-Nitronoracronycins, Molekülvariationen des cytostatisch wirksamen Acronycins.