title: Blood viscosity measurement for screening of affecting blood circulation.
abstract: An in vitro screening test for drugs that decrease blood viscosity was carried out on many pharmacologically active compounds such as Ca-antagonists, alpha-antagonists, beta-antagonists, alpha, beta-antagonists, alpha-agonists, beta-agonists, alpha, beta-agonists, autacoids and others. The results revealed that various types of microcirculatory-improving drugs, vasodilators, and antagonists decreased blood viscosity, while the agonists and autacoids had no significant effect. These findings suggest that this assay is useful for screening compounds related to hemorheology.
authors.affiliation: Research Institute for Biology & Chemistry, Tsumura & Co., Ibaraki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kubota
authors.forename: M
authors.initials: M
authors.lastname: Chin
authors.forename: H
authors.initials: H
authors.lastname: Mitsuhashi
mesh_terms: D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012212:Rheology