Commercial rodent diets and nephrocalcinosis in weanling female rats.
This study addresses the questions to what extent commercial rodent diets would induce nephrocalcinosis, and which dietary components would be responsible for inducing this condition. For this purpose, 10 commercial diets were analysed for selected components and fed to weanling female rats. On the basis of histological inspection of kidney sections, two diets were found to produce significant nephrocalcinosis. The condition could be considered relatively mild because concentrations of Ca in kidney tissue were not increased. There was considerable variation between the commercial diets in the (analysed) concentrations of Ca, P, Mg and protein as well as in the diet-induced urinary pH, urinary volume and caecal weight. Of these parameters, only the dietary Ca:P ratio and group mean urinary pH correlated significantly with the observed variation in group mean calcification scores, the relationships being negative. It is suggested that the Ca:P ratio of commercial rodent diets is an important determinant of nephrocalcinosis.
Ritskes-Hoitinga
J
J
Department of Laboratory Animal Science, State University, Utrecht, The Netherlands.
Mathot
J N
JN
Danse
L H
LH
Beynen
A C
AC
D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D000830:Animals, Laboratory; D001835:Body Weight; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D009397:Nephrocalcinosis / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains