Helicobacter pylori and gastric histamine concentrations.
An enzyme isotopic assay was used to determine the histamine concentration in the gastric mucosa of patients positive for Helicobacter pylori with (n = 11) and without duodenal ulceration (n = 9) and in negative controls (n = 7). A significant difference was observed when the histamine content of H pylori negative subjects was compared with that of positive patients. On the other hand, there was no significant difference in histamine concentration between H pylori positive patients with duodenal ulceration and those without duodenal ulceration. H pylori positive patients with and without duodenal ulceration had significantly lower gastric histamine concentrations than H pylori negative subjects. The lower gastric histamine concentration observed in H pylori positive patients might be due to increased histamine release which could in turn induce increased gastric acid secretion.
Queiroz
D M
DM
Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil.
Mendes
E N
EN
Rocha
G A
GA
Cunha-Melo
J R
JR
Barbosa
A J
AJ
Lima
G F
GF
Oliveira
C A
CA
D000328:Adult; D001706:Biopsy; D004381:Duodenal Ulcer / Q000150:complications / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications / Q000378:metabolism*; D016480:Helicobacter pylori; D006632:Histamine / Q000032:analysis*; D006801:Humans; D008297:Male
D006632:Histamine