title: Synthesis and DNA-binding properties of polyamine analogues.
abstract: The synthesis of a series of novel polyamine analogues is reported. The DNA binding of these compounds and a variety of other polyamines were compared with their IC50 values against HeLa cell. There seemed to be no apparent correlation between the DNA binding and toxicity against HeLa cells.
authors.affiliation: Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.
authors.forename: M L
authors.initials: ML
authors.lastname: Edwards
authors.forename: R D
authors.initials: RD
authors.lastname: Snyder
authors.forename: D M
authors.initials: DM
authors.lastname: Stemerick
mesh_terms: D000478:Alkylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D001482:Base Composition; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000187:drug effects / Q000378:metabolism*; D004996:Ethidium / Q000378:metabolism; D006367:HeLa Cells; D015394:Molecular Structure; D011073:Polyamines / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D013096:Spermine / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011073:Polyamines; D013096:Spermine; D004247:DNA; D004996:Ethidium