title: Assignment of two enzyme loci to the X chromosome of Anopheles quadrimaculatus species A.
abstract: Analysis of isozyme variability in four natural populations of Anopheles quadrimaculatus Species A indicated that the loci for Malic enzyme (Me) and Mannose phosphate isomerase-1 (Mpi-1) are on the X chromosome. There were female heterozygotes, but no male heterozygotes were observed. Strains fixed for fast- and slow-migrating allozymes were devised and crossed. Progeny phenotypes conformed to expectations for sex linkage; female progeny were heterozygous, and male progeny were hemizygous for the maternal allele. The three-point cross, using the Me and Mpi-1 loci with the sex-linked mutant rose eye (ro), established the gene sequence Mpi-1-11.1-Me-40.8-ro.
authors.affiliation: Department of Entomolgy and Nematology, University of Florida, Gainesville.
authors.forename: G C
authors.initials: GC
authors.lastname: Lanzaro
authors.forename: S E
authors.initials: SE
authors.lastname: Mitchell
authors.forename: S K
authors.initials: SK
authors.lastname: Narang
authors.forename: J A
authors.initials: JA
authors.lastname: Seawright
mesh_terms: D000818:Animals; D000852:Anopheles / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D008291:Malate Dehydrogenase / Q000235:genetics*; D008297:Male; D008359:Mannose-6-Phosphate Isomerase / Q000235:genetics*; D014960:X Chromosome
chemical_list: D008291:Malate Dehydrogenase; D008359:Mannose-6-Phosphate Isomerase