Tubuloglomerular feedback response in rats with antithymocyte serum-induced glomerular lesions.
Glomerular function and tubuloglomerular feedback (TGF) responses were studied in rats treated with antithymocyte rabbit serum (ATS). Microscopic findings revealed extensive mesangial cell loss and injury, enlarged capillary lumen, and decreased tortuosity of glomerular capillaries. Whole kidney GFR and SNGFR were lower in ATS-treated rats than in control rats (1.04 +/- 0.04 vs 0.94 +/- 0.03 ml/min/g kidney weight, 32 +/- 2 vs 27 +/- 1 nl/min, respectively) due to a decrease in Kf (0.017 +/- 0.001 vs 0.021 +/- 0.001 nl/s/mmHg). The magnitude of the TGF responses of SNGFR was less in ATS rats than in control rats (17% +/- 4% vs 34% +/- 5%), but that of SFP was not significantly different (18% +/- 2% vs 23% +/- 1%). These results indicate that the mesangial cells are necessary for full expression of the TGF mechanism and suggest the involvement of changes in Kf in the TGF mechanism.
Aizawa
C
C
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Nosaka
K
K
Imaki
H
H
Suzuki
K
K
Uwatoko
S
S
Taniguchi
S
S
Kawamura
M
M
Kurokawa
K
K
D000818:Animals; D000961:Antilymphocyte Serum / Q000008:administration & dosage; D005246:Feedback; D005919:Glomerular Filtration Rate / Q000502:physiology; D005920:Glomerular Mesangium / Q000276:immunology / Q000473:pathology; D007678:Kidney Glomerulus / Q000503:physiopathology*; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D009399:Nephrons / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains
D000961:Antilymphocyte Serum