title: Comparison of in vitro and in vivo release characteristics of acetaminophen from gradient matrix systems.
abstract: An effort was made to correlate the in vivo and in vitro release data of acetaminophen from two formulations of a recently developed controlled-release system, the Gradient Matrix System (GMS-1 and GMS-2). The in vivo release curves, obtained by deconvolution of the plasma concentration time plots, showed a small inter-subject variability. GMS-1 with fastest in vitro release also showed fastest in vivo release. A good relationship was only found after time-scaling of the release data.
authors.affiliation: Pharmaceutical Development Department, Duphar BV, Weesp, The Netherlands.
authors.forename: E M
authors.initials: EM
authors.lastname: van Bommel
authors.forename: M
authors.initials: M
authors.lastname: Raghoebar
authors.forename: J J
authors.initials: JJ
authors.lastname: Tukker
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000465:Algorithms; D003692:Delayed-Action Preparations; D006801:Humans
chemical_list: D003692:Delayed-Action Preparations; D000082:Acetaminophen