Is hsp70 the cellular thermometer?
Cells respond to an increase in temperature by inducing the synthesis of the heat shock proteins, which are a small set of evolutionarily conserved proteins. We review the evidence leading us to suggest that the free pool of one of these proteins, hsp70, serves as a cellular thermometer that regulates the expression of all heat shock proteins.
Craig
E A
EA
Department of Physiological Chemistry, University of Wisconsin-Madison 53706.
Gross
C A
CA
D000818:Animals; D005057:Eukaryotic Cells / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000502:physiology*; D011387:Prokaryotic Cells / Q000502:physiology*; D013696:Temperature
D006360:Heat-Shock Proteins