title: [Medico-genetic counselling of the relatives of patients with type I diabetes mellitus].
abstract: Population-genetic surveys show that for the relatives of patients with type I diabetes mellitus (the 1st degree of kinship) a risk of developing the same type of diabetes is 2-5%. Tables of repeated risk of developing diabetes mellitus (DM) of type I for persons with a different number of relatives affected by this type of DM were calculated on the basis of analysis of 2000 family histories of DM patients (a random sampling). A risk of developing this disease is in direct correlation with the number of sick and healthy relatives and their age. The presence of patients with type II DM in a family does not influence the risk of developing type I DM. Risk assessments are of prognostic rather than diagnostic value. The effectiveness of medico-genetic counselling can be increased with the help of various genetic markers, associated with type I DM. Risk assessment must lay the basis of a follow-up of persons with aggravated heredity by investigating immunological, hormonal and metabolic derangements in them.
authors.forename: T L
authors.initials: TL
authors.lastname: Kuraeva
authors.forename: A S
authors.initials: AS
authors.lastname: Sergeev
authors.forename: A G
authors.initials: AG
authors.lastname: Mazovetskiĭ
authors.forename: A G
authors.initials: AG
authors.lastname: Koroleva
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005817:Genetic Counseling; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D012306:Risk
chemical_list: D005819:Genetic Markers
vernacular_title: Mediko-geneticheskoe konsul'tirovanie rodstvennikov bol'nykh sakharnym diabetom I tipa.