[Killing activity of lymphokine-activated killer (LAK) cells on fresh acute leukemia cells].
In this study, the killing activity of LAK cells on fresh acute leukemia (AL) cells of 13 patients was examined. The LAK cells were prepared from the peripheral blood lymphocytes of 70 normal healthy donors. The results showed that LAK cells have obvious killing activity on AL cells, especially, the acute lymphoblastic leukemia (ALL) cells. The killing activity varies significantly on the same type of AL cells from different patients. Probably, age of patients is one of the influencing factors on this phenomenon. Moreover, the results indicated that the killing activity of LAK cells on AL cells was closely related to the rate of proliferation of AL cells.
Zhao
T H
TH
Chengde Medical College, Hebei.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000502:physiology*; D007948:Leukemia, Monocytic, Acute / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D014407:Tumor Cells, Cultured