Selective synthesis of 2,4-bis(O-methoxypolyethylene glycol)-6-chloro-s-triazine as a protein modifier.
2,4-Bis(O-methoxypolyethylene glycol)-6-chloro-s-triazine, a protein modifier with two polyethylene glycol chains (activated PEG2) was synthesized from monomethoxypolyethylene glycol and cyanuric chloride using zinc oxide as a catalyst by the improved method of a previous study (Matsushima et al., Chem. Lett. 7, 773, 1980). The product was identified as activated PEG2 without contamination of by-products with chromatographic and structural analysis.
Ono
K
K
Research Laboratories, Sumitomo Pharmaceutical Co. Ltd., Kanagawa, Japan.
Kai
Y
Y
Maeda
H
H
Samizo
F
F
Sakurai
K
K
Nishimura
H
H
Inada
Y
Y
D002384:Catalysis; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000138:chemical synthesis*; D011506:Proteins / Q000187:drug effects*
D011506:Proteins; D011092:Polyethylene Glycols; C029761:2,4-bis(O-methoxypolyethylene glycol)-6-chloro-s-triazine