title: Previous experience facilitates preservation of spatial memory in the senescent rat.
abstract: In an attempt to evaluate whether previous training antagonizes age-related memory deficits, aged rats with previous training experience were compared with aged and young naive rats in the Morris water maze test. The findings of our study indicate that experience seems to facilitate the preservation of the spatial reference memory for 12 months in the aged rat, whereas senescent naive animals showed the usual age-related memory deficits. However, experience seems task-specific since the same aged rats fail to acquire a new different task.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Pitsikas
authors.forename: L
authors.initials: L
authors.lastname: Biagini
authors.forename: S
authors.initials: S
authors.lastname: Algeri
mesh_terms: D000375:Aging / Q000523:psychology*; D000818:Animals; D004193:Discrimination Learning; D004924:Escape Reaction; D008297:Male; D011939:Mental Recall; D009949:Orientation; D051381:Rats; D011919:Rats, Inbred Strains; D012153:Retention, Psychology