Effect of alpha-glucosidase inhibition on the nonenzymatic glycation of glomerular basement membrane.
1. The effect of the alpha-glucosidase inhibitor Acarbose on integrated glycemic control and on nonenzymatic glycation of glomerular basement membrane was examined in streptozotocin diabetic rats. 2. Treatment with Acarbose for 8 weeks after induction of diabetes significantly reduced the level of HbA1c and of glomerular basement membrane glycation. 3. Acarbose exerts a significant antihyperglycemic effect and has a salutary influence on the nephropathic process in experimental diabetes.
Cohen
M P
MP
University City Science Center, Philadelphia, PA 19104.
Klepser
H
H
Wu
V Y
VY
D000818:Animals; D001485:Basement Membrane / Q000201:enzymology*; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D005947:Glucose / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D006909:Hydroxyproline / Q000378:metabolism; D066298:In Vitro Techniques; D007678:Kidney Glomerulus / Q000201:enzymology*; D008297:Male; D051381:Rats
D001786:Blood Glucose; D005947:Glucose; D006442:Glycated Hemoglobin; D065089:Glycoside Hydrolase Inhibitors; D006909:Hydroxyproline