Genotoxicity data supporting the proposed metabolic activation of ethyl carbamate (urethane) to a carcinogen: the problem now posed by methyl carbamate.
Ashby
J
J
Imperial Chemical Industries, Plc, Central Toxicology Laboratory, Macclesfield, Cheshire, Great Britain.
D000818:Animals; D001711:Biotransformation; D002219:Carbamates / Q000493:pharmacokinetics / Q000633:toxicity*; D002273:Carcinogens; D051379:Mice; D010084:Oxidation-Reduction; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D014520:Urethane / Q000493:pharmacokinetics / Q000633:toxicity*
D002219:Carbamates; D002273:Carcinogens; D014520:Urethane; C036868:methyl carbamate