title: Mutagenicity of ozonation and chlorination products from p-hydroxybenzaldehyde.
abstract: p-Hydroxybenzaldehyde, a component of soil humic substances, was ozonated and chlorinated. The ether extract and the residue were subjected to the Ames assay; mutagenic activities were identified. The non-ionic resin CSP800 and the anion exchange resin CHPA25 were used for separation of mutagenic compounds. The compounds in the water layer were not adsorbed on CSP800 or CHPA25 and exhibited strong mutagenic activity. Mutagenic activity was reduced as the added chlorine was increased. Ether extracts were analyzed by gas chromatography-mass spectrometry (GC-MS) and chloral, 1,3-dichloro-2-propanone, 1,2,3-trichloro-1-propene, tetrachloroethylene and 1,1,1,3,3-pentachloro-2-propanone were identified as mutagenic compounds.
authors.affiliation: Mie University Hospital, Tsu City, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Ose
authors.forename: H
authors.initials: H
authors.lastname: Nagase
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Kito
authors.forename: K
authors.initials: K
authors.lastname: Sumida
mesh_terms: D000818:Animals; D001547:Benzaldehydes / Q000302:isolation & purification / Q000494:pharmacology*; D001711:Biotransformation; D002852:Chromatography, Ion Exchange; D008401:Gas Chromatography-Mass Spectrometry; D006843:Hydrocarbons, Chlorinated / Q000302:isolation & purification / Q000494:pharmacology*; D007659:Ketones / Q000302:isolation & purification / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D001547:Benzaldehydes; D006843:Hydrocarbons, Chlorinated; D007659:Ketones; D009153:Mutagens; C011483:4-hydroxybenzaldehyde