title: The edema inducing activity of phospholipase A2 enzymes.
abstract: The edema inducing activity of phospholipase A2 (PLA2) enzymes from snake venoms and porcine pancreas was investigated using mouse paw as experimental model. All ten PLA2 enzymes exhibited potent edema inducing activity. PLA2, however, is generally not the major edema inducing component of snake venom. Chemical modification studies indicated that enzymatic activity of PLA2 was required for its edema inducing activity. All PLA2 enzymes examined displayed a rapid onset edema which was suppressed by pretreatment of the mice with antihistamine. Dexamethasone pretreatment also inhibited edemas elicited by some PLA2 enzymes.
authors.affiliation: Department of Biochemistry, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: N H
authors.initials: NH
authors.lastname: Tan
authors.forename: M N
authors.initials: MN
authors.lastname: Saifuddin
authors.forename: W Y
authors.initials: WY
authors.lastname: Yong
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced*; D005121:Extremities; D006633:Histamine Antagonists / Q000494:pharmacology; D006868:Hydrolysis; D051379:Mice; D010179:Pancreas / Q000201:enzymology; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D054467:Phospholipases A2; D012910:Snake Venoms / Q000633:toxicity; D013552:Swine
chemical_list: D006633:Histamine Antagonists; D012910:Snake Venoms; D003907:Dexamethasone; D004155:Diphenhydramine; D010741:Phospholipases A; D054467:Phospholipases A2