Fracture healing of chick femurs in tissue culture.
Embryonic chick femurs were isolated, and a transverse osteotomy was performed at the midshaft. The femurs were transplanted individually onto the host chorioallantoic membrane and incubation continued. Cultured femurs were harvested at intervals from 1 to 9 days after the transplant. Histologic examinations showed that repair progressed rapidly: the fracture gap was invaded by blood vessels and fibrous ingrowth. Ossification followed, and the repair process was completed by Day 9.
Takahashi
K
K
Department of Orthopedics, Nagasaki University School of Medicine, Japan.
Shanahan
M D
MD
Coulton
L A
LA
Duckworth
T
T
D000481:Allantoin; D000818:Animals; D002146:Bony Callus / Q000033:anatomy & histology / Q000502:physiology; D002642:Chick Embryo; D002823:Chorion; D046508:Culture Techniques; D004195:Disease Models, Animal; D004531:Eggs; D005264:Femoral Fractures / Q000473:pathology* / Q000503:physiopathology; D010012:Osteogenesis / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D000481:Allantoin