title: Importance of chloride in the development of salt-induced angiotensin II hypertension in rats.
abstract: This study attempted to evaluate the effect of anion associated with sodium loading on the development of angiotensin II (AII)-induced hypertension in rats. Hypertension was induced by intraperitoneal infusion of AII(125 ng/min) for 12 days via miniosmotic pump (systolic blood pressure on day 12, 143 +/- 3 mm Hg). High dietary intake of sodium chloride significantly augmented the AII-induced hypertension (systolic blood pressure on day 12, 166 +/- 4 mm Hg), but equimolar sodium loading provided as sodium citrate failed to enhance AII hypertension (systolic blood pressure on day 12, 136 +/- 8 mm Hg). Thus, the data suggest that the full expression of salt (NaCl) sensitivity in AII hypertension depends on high dietary intake of both sodium and chloride.
authors.affiliation: Fourth Department of Internal Medicine, School of Medicine, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: E
authors.initials: E
authors.lastname: Ogata
authors.forename: T
authors.initials: T
authors.lastname: Fujita
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage*; D000818:Animals; D002712:Chlorides / Q000008:administration & dosage* / Q000494:pharmacology; D002951:Citrates / Q000008:administration & dosage / Q000494:pharmacology; D019343:Citric Acid; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D002712:Chlorides; D002951:Citrates; D000804:Angiotensin II; D019343:Citric Acid; D012965:Sodium Chloride