Sex chromosome marker: clinical significance and DNA characterization.
Two patients are described with a virtually identical marker sex chromosome that was so small as to defy classification by conventional cytogenetic studies. DNA hybridization with Y probes allows classification into Y or non-Y, and in situ hybridization with X centromere specific sequences, into X or non-X. One patient was proven to have a Y fragment, and the second, an X fragment. DNA characterization is important since prognosis and clinical management depends on proper identification of the small marker sex chromosome.
Johnson
V P
VP
Department of OB/GYN, University of South Dakota School of Medicine, Vermillion, SD 57069.
McDonough
P G
PG
Cheung
S W
SW
Sun
L
L
D002675:Child, Preschool; D002871:Chromosome Banding; D004247:DNA / Q000032:analysis*; D015342:DNA Probes; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization; D014424:Turner Syndrome / Q000175:diagnosis / Q000235:genetics*; D014960:X Chromosome / Q000737:chemistry; D014998:Y Chromosome / Q000737:chemistry
D015342:DNA Probes; D005819:Genetic Markers; D004247:DNA