[Hemodynamic changes in patients with chronic cor pulmonale secondary to COPD and effect of sodium nitroprusside administration].
Pulmonary hemodynamic changes were studied with Swan-Ganz right heart catheterization in 19 patients with chronic cor pulmonale secondary to COPD. HR, RVP, PAPM, PVR, PCWP, RWI and PaCO2 were significantly higher and PaO2 and PH lower in patients with decompensated than those with compensated heart function. Nitroprusside lowered effectively pulmonary arterial pressure and pulmonary vascular resistance. Meanwhile, the drug also lowered PaO2 when the patient was breathing air but did not so or even increased it when breathing oxygen.
Wang
H Y
HY
Beijing Respiratory Disease Research Division, Beijing Red Cross Chaoyang Hospital.
Zhang
H Y
HY
Weng
X Z
XZ
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000627:therapeutic use*; D011651:Pulmonary Artery / Q000187:drug effects; D011660:Pulmonary Heart Disease / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*
D009599:Nitroprusside