title: Protein kinase C in the promyelocytic leukemia cell differentiation of granulocytes.
abstract: When the leukemia cells in 14 patients with acute promyelocytic leukemia (APL) were induced by all-trans retinoic acid (RA) treatment, the activity of protein kinase C (PKC) increased with the differentiation. In the control cells, the activity of PKC was only 47 +/- 39.3 pmol.mg-1/min, while it was 149.3 +/- 150.1 pmol.mg-1/min after differentiation. There were 90.1 +/- 7.2% promyelocytes in the control group, and 8.9 +/- 5.6% in the induction group. Therefore, we think that there is a close correlation between PKC and the differentiation of promyelocytic leukemia cells.
authors.affiliation: Department of Hematology, Jinling Hospital, Nanjing.
authors.forename: X Z
authors.initials: XZ
authors.lastname: Wu
authors.forename: G Y
authors.initials: GY
authors.lastname: Shao
authors.forename: S R
authors.initials: SR
authors.lastname: Chen
authors.forename: M E
authors.initials: ME
authors.lastname: Huang
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Wang
mesh_terms: D000328:Adult; D002454:Cell Differentiation / Q000187:drug effects; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000201:enzymology / Q000473:pathology*; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism*; D014212:Tretinoin / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D014212:Tretinoin; D011493:Protein Kinase C