Evidence that nitric oxide modulates food intake in mice.
Nitric oxide (NO) may be an intercellular modulator within the central nervous system. L-arginine, which results in NO synthesis, increased food intake in mice while the inhibitor of NO synthesis, L-NG-nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arginine, partially reversed the inhibitory effect of L-NO Arg on food intake. These findings suggest the possibility that NO may be a physiological modulator of food intake and that the possibility of exploring the utility of L-NO arg in the treatment of obesity should be explored.
Morley
J E
JE
Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO.
Flood
J F
JF
D000818:Animals; D001120:Arginine / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*; D013237:Stereoisomerism
D009569:Nitric Oxide; D001120:Arginine