Effect of antiepileptic drugs valproic acid, carbamazepine and ethosuccimide on exploratory behaviour in mice.
Valproic acid in 100, 200 and 400 mg/kg doses produced a significant dose dependent decrease in exploratory behaviour, tested as number of head dips on the hole board. In the open field test, control mice entered less number of peripheral squares and more number of central squares on day 4 as compared to day 1 of the test. In the lower doses (100 and 200 mg/kg) valproic acid increased central square entries on day 1 with significant decrease by all doses on subsequent days indicating inhibition of exploratory behaviour. However, in peripheral square entry they followed the same pattern as control mice. Neither carbamazepine (10 and 20 mg/kg) nor ethosuccimide (100 and 200 mg/kg) affected exploratory behaviour in either the hole board or open field test.
Rao
S
S
Department of Pharmacology, St. John's Medical College, Bangalore, India.
Rajesh
K R
KR
Joseph
T
T
D000704:Analysis of Variance; D000818:Animals; D002220:Carbamazepine / Q000494:pharmacology*; D005013:Ethosuximide / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D014635:Valproic Acid / Q000494:pharmacology*
D002220:Carbamazepine; D005013:Ethosuximide; D014635:Valproic Acid