[Effects of strophanthin K and beta-acetyldigoxin in vitro on energy transformation of myocardial contractile protein system in toxic-allergic lesions of the cardiac muscle].
Strophanthin K and beta-acetyldigoxin in vitro in concentration of 10(-6) M in TAM sharply increased the force generated by isolated myocardial contractile protein system (MCPS), and normalized the work performed by the system. This was accompanied by increase of ATP internal energy release (enthalpy) intensity, while a portion of energy, dissipating into heat did not increase proportionally. The mechanical efficiency of contractile process was normalized due to beta-acetyldigoxin, and exceeded the normal level due to strophanthin K effect. Strophanthin K proved a positive effect on quantitative and qualitative economy of MCPS energy utilization, while beta-acetyldigoxin effected, on the whole, extensively.
Karsanov
N V
NV
Magaldadze
V A
VA
Macharashvili
T N
TN
D000113:Acetyldigoxins / Q000494:pharmacology*; D000818:Animals; D003285:Contractile Proteins / Q000187:drug effects / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D006967:Hypersensitivity / Q000150:complications*; D066298:In Vitro Techniques; D009200:Myocardial Contraction; D009205:Myocarditis / Q000209:etiology / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D013328:Strophanthins / Q000494:pharmacology*
D000113:Acetyldigoxins; D003285:Contractile Proteins; D013328:Strophanthins; C029082:strophanthin K
Deĭstvie strofantina K i beta-atsetildigoksina in vitro na preobrazovanie énergii sistemoĭ sokratitel'nykh belkov miokarda pri toksiko-allergicheskom porazhenii myshtsy serdtsa.