Vasopressin and cortisol levels in response to glycine infusion.
The plasma vasopressin and serum cortisol concentrations were recorded in 7 healthy volunteers receiving an intravenous infusion of 1 l of isosmotic (2.2%) glycine solution during 20 min. The infusion elicited a significant increase in the plasma vasopressin level by a mean of 60% (SEM 13) above baseline level. The serum cortisol level increased only in the patient who developed signs of glycine toxicity. These results suggest that a glycine solution has water-retaining properties by stimulating the vasopressin secretion but usually not by increasing cortisol secretion.
Hahn
R G
RG
Department of Anaesthesiology, Huddinge University Hospital, Sweden.
Stalberg
H P
HP
Gustafsson
S A
SA
D000042:Absorption; D000328:Adult; D005998:Glycine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007262:Infusions, Intravenous; D007430:Intraoperative Care; D008297:Male; D011468:Prostatectomy; D013268:Stimulation, Chemical; D007507:Therapeutic Irrigation; D014667:Vasopressins / Q000097:blood*
D014667:Vasopressins; D005998:Glycine; D006854:Hydrocortisone