[Biotransformation and toxicity of xenobiotics in various routes of administration of vitamin A into the rat body].
Deficiency of vitamin A in rats caused a decrease in metabolic rate of acetanilide as well as in elimination of voltaren from blood plasma, while excess of the vitamin (3,000 IU/kg) stimulated voltaren elimination and increased excretion with urine of aminophenol conjugates of acetanilide with sulfuric and glucuronic acids. Under conditions of vitamin A deficiency formation of acetanilide toxic metabolites was increased as a result of which excretion of mercapturic acids with urine was elevated but excess of vitamin A and its hyperdose inhibited these reactions. At the same time, deficiency of vitamin A amplified the paracetamol and voltaren toxicity and its excess exhibited protective effects.
Pentiuk
A A
AA
Gutsol
V I
VI
Bogdanov
N G
NG
D000082:Acetaminophen / Q000493:pharmacokinetics / Q000633:toxicity*; D000083:Acetanilides / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D004008:Diclofenac / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D013464:Sulfuric Acids / Q000378:metabolism; D014801:Vitamin A / Q000378:metabolism*; D014802:Vitamin A Deficiency / Q000378:metabolism*
D000083:Acetanilides; D005965:Glucuronates; D013464:Sulfuric Acids; D014801:Vitamin A; D004008:Diclofenac; D000082:Acetaminophen; D005978:Glutathione
Biotransformatsiia i toksichnost' ksenobiotikov pri razlichnom postuplenii vitamina A v organizm krys.