Enhanced lung maturation in cocaine-exposed rabbit fetuses.
Because of cocaine's possible effect on the incidence of respiratory distress syndrome in offspring of cocaine-addicted mothers, we have studied the effects of maternal exposure to cocaine on the functional anatomy of fetal rabbit lungs. Pregnant dams were injected s.c. daily with either cocaine (18 mg/kg) or an equal volume of 0.9% NaCl at 24, 25, and 26 d gestation. Cocaine metabolites were confirmed both in urine of treated dams and in fetal amniotic fluid. Serum cortisol levels were higher in treated dams than in controls. Fetuses were delivered through hysterotomy at 27 d. Tracheas were cannulated and a volume-pressure diagram was obtained during initial lung inflation-deflation. Volume was measured for 2 min at each pressure (P) increment of 5 cm H2O. Body weights and dry lung weights were comparable between the two groups. In contrast, cocaine-exposed lungs differed from controls as follows: 1) wet lung weights were lower (0.79 versus 0.89 g, p less than 0.02); 2) opening pressure was lower (P25 versus P35); 3) volume (mL/kg) was higher in treated animals at each pressure step (p less than 0.05); 4) end-deflation volume at P0 was higher (30.4 versus 0.8 mL/kg, p less than 0.001); and 5) bubbles released from saccules by micropuncture, which were stable by Pattle's criteria, had estimated surface tension near zero (controls produced no stable bubbles). Light micrographs of cocaine-exposed fetuses revealed more secondary septa and thinner septal walls than controls.(ABSTRACT TRUNCATED AT 250 WORDS)
Kain
Z N
ZN
Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 11042.
Chinoy
M R
MR
Antonio-Santiago
M T
MT
Marchitelli
R N
RN
Scarpelli
E M
EM
D000818:Animals; D002395:Catecholamines / Q000502:physiology; D003042:Cocaine / Q000633:toxicity*; D005260:Female; D005325:Fetal Organ Maturity / Q000187:drug effects; D005865:Gestational Age; D005938:Glucocorticoids / Q000502:physiology; D008168:Lung / Q000187:drug effects* / Q000196:embryology / Q000473:pathology; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011817:Rabbits; D019966:Substance-Related Disorders / Q000473:pathology
D002395:Catecholamines; D005938:Glucocorticoids; D003042:Cocaine