title: Large-cell lymphoma presenting with hepatic sinusoidal infiltration.
abstract: We describe a case of large-cell lymphoma of B-cell phenotype with clinicopathologic features resembling malignant histiocytosis. The clinical presentation was characterized by fever, anemia, thrombocytopenia, coagulopathy, and elevated liver enzyme levels. These features and the finding of a predominantly sinusoidal infiltrate of neoplastic cells on liver biopsy raised the suspicion of malignant histiocytosis. The patient subsequently developed supraclavicular lymphadenopathy, which proved to be due to a diffuse large-cell lymphoma. Immunophenotypic studies performed on the lymph node and the original liver biopsy specimen established the B-cell nature of neoplastic cells at both sites. This case highlights a rare pattern of hepatic involvement by large-cell lymphoma, and contrasts the latter with other hematologic disorders associated with hepatic sinusoidal infiltrates.
authors.affiliation: Department of Pathology, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Trudel
authors.forename: T
authors.initials: T
authors.lastname: Aramendi
authors.forename: S
authors.initials: S
authors.lastname: Caplan
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D001706:Biopsy; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D009361:Neoplasm Invasiveness
chemical_list: D015703:Antigens, CD