title: Comparison of withdrawal of typical and atypical antipsychotic drugs: a case study.
abstract: Haloperidol and clozapine were rapidly withdrawn from a schizophrenic patient on separate occasions several months apart. Mental status changes and fluctuations in involuntary movements were carefully observed under both conditions. Although little change in either mental status or involuntary movements was observed within the 3 weeks following the withdrawal of haloperidol, marked deterioration in mental status and involuntary movements occurred within 1 week of withdrawal of clozapine. Implications of this differential response to withdrawal of antipsychotic medications are discussed.
authors.affiliation: Cleveland Veterans Administration Medical Center, Ohio 48101.
authors.forename: L D
authors.initials: LD
authors.lastname: Alphs
authors.forename: H S
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000208:Acute Disease; D000328:Adult; D000553:Ambulatory Care; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006760:Hospitalization; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011605:Psychoses, Substance-Induced / Q000209:etiology / Q000523:psychology; D012559:Schizophrenia / Q000139:chemically induced / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
chemical_list: D003024:Clozapine; D006220:Haloperidol