Tumoricidal effector molecules of murine macrophages.
Activated macrophages secrete a variety of factors affecting proliferation or viability of neoplastic cells. Factors described previously are discussed for their relevance as effector molecules for the selective destruction of tumor cells by activated macrophages and compared to a recently characterized high-molecular-weight tumoricidal activity secreted by activated murine bone-marrow-derived macrophages.
Schwamberger
G
G
Max-Planck-Institut für Immunbiologie, Freiburg, FRG.
Flesch
I
I
Ferber
E
E
D000818:Animals; D003602:Cytotoxicity, Immunologic; D003603:Cytotoxins / Q000378:metabolism; D010450:Endopeptidases / Q000276:immunology; D005609:Free Radicals; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D003603:Cytotoxins; D005609:Free Radicals; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D010450:Endopeptidases