title: Comparison between exercise myocardial perfusion and wall motion using 201Tl and 191Irm simultaneously.
abstract: By exploiting the ultrashort half-life 191Irm as tracer for left ventricular first-pass angiocardiography and 201Tl as myocardial perfusion agent, direct comparison between myocardial perfusion and regional wall motion was obtained during the same exercise stress test in patients with non-significant coronary artery disease, in patients with recent myocardial infarction, and in patients six weeks after successful percutaneous transluminal coronary angioplasty (PTCA). A good agreement between regional myocardial perfusion and regional wall motion was observed in patients with non-significant coronary artery disease and in most patients with recent myocardial infarction. In contrast, discrepancies occurred at maximal exercise in patients studied six weeks after successful PTCA: only 38% of the patients with no evidence of restenosis and with a completely normal myocardial perfusion scintigraphy had a normal regional wall motion at maximal exercise stress. According to these results, a normal uptake of 201Tl six weeks after PTCA would mean that the circulation has been successfully reestablished but without predicting the functional capacities of the myocardial cells which remain altered at least six weeks after the revascularization procedure in about two-thirds of the patients. We conclude that 191Irm in combination with 201Tl offers the opportunity of performing myocardial perfusion and wall motion studies simultaneously both at rest and during exercise.
authors.affiliation: Division of Nuclear Medicine and Cardiology, Middlelheim General Hospital, Antwerpen, Belgium.
authors.forename: P R
authors.initials: PR
authors.lastname: Franken
authors.forename: A A
authors.initials: AA
authors.lastname: Dobbeleir
authors.forename: H R
authors.initials: HR
authors.lastname: Ham
authors.forename: R
authors.initials: R
authors.lastname: Ranquin
authors.forename: S
authors.initials: S
authors.lastname: Lieber
authors.forename: F
authors.initials: F
authors.lastname: Van Den Branden
authors.forename: P
authors.initials: P
authors.lastname: Van Den Heuvel
authors.forename: C
authors.initials: C
authors.lastname: Brihaye
authors.forename: M
authors.initials: M
authors.lastname: Guillaume
authors.forename: F F
authors.initials: FF
authors.lastname: Knapp
mesh_terms: D000328:Adult; D000368:Aged; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005080:Exercise Test; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes / Q000008:administration & dosage
chemical_list: D007496:Iridium Radioisotopes; D013794:Thallium Radioisotopes