Genes for epilepsy mapped in the mouse.
The neurological mutant mouse strain E1 is a model for complex partial seizures in humans. The inheritance of epileptic seizures with seven conventional chromosomal markers and over 60 endogenous proviral markers was studied by means of back-crosses of E1 with two seizure-resistant strains, DBA/2J and ABP/LeJ. The major gene responsible for this epileptic phenotype (El-1) was localized to a region distal with respect to the centromere on chromosome 9. At least one other gene, El-2, linked to proviral markers on chromosome 2, also influences the seizure phenotype. In addition, a potential modifier of seizures was detected in the DBA/2J background. The location of El-1 on distal chromosome 9 may allow identification of an epilepsy candidate gene in humans on the basis of conserved synteny with human chromosome 3.
Rise
M L
ML
Department of Biology, Boston College, Chestnut Hill 02167.
Frankel
W N
WN
Coffin
J M
JM
Seyfried
T N
TN
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004827:Epilepsy / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D011995:Recombination, Genetic; D012640:Seizures / Q000235:genetics; D012984:Software