[Functional activity of antibody-producing cells in mice with experimental influenza].
The paper presents the findings on the functional activity of specific antibody-forming cells (AFC) in the time-course of the primary influenza infection in mice. The concept of AFC functional activity is validated. Studying of the AFC population in the pool of splenocytes based on the analysis of functional activity permitted one to make a detailed description of specific AFC, and make a series of conclusions of the technique of AFC identification, reveal the changes in the structure of the virus-specific AFC population under the influenza infection which are not related to their quantity. Principle difference was revealed in the time-course of AFC functional activity in various patterns of influenza. Continuous changes in the AFC structure were observed during the whole period of observation.
Dukhin
A I
AI
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology*; D000918:Antibody Specificity; D000921:Antibody-Producing Cells / Q000276:immunology* / Q000473:pathology; D002452:Cell Count; D004195:Disease Models, Animal; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000473:pathology; D013154:Spleen / Q000473:pathology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G
Funktsional'naia aktivnost' antiteloobrazuiushchikh kletok v dinamike éksperimental'noĭ grippoznoĭ infektsii mysheĭ.