In-vivo effects of solar-simulated ultraviolet irradiation on antioxidant enzymes and lipid peroxidation in human epidermis.
The effects of solar-simulated UV-irradiation on the activity of antioxidant enzymes and the amount of diene conjugation were studied in human epidermis in vivo. A single dose of UV-irradiation was found to result in a transient reduction in superoxide dismutase activity and this was followed by increased amounts of conjugated diene double bonds, an index for oxidative stress. This suggests that in-vivo exposure of human epidermis to solar-simulated UV-irradiation causes changes in the enzymic antioxidant defence system which, in turn, are accompanied by increased level of oxidative stress.
Punnonen
K
K
Department of Physiology, University of Turku, Finland.
Autio
P
P
Kiistala
U
U
Ahotupa
M
M
D000293:Adolescent; D000328:Adult; D002374:Catalase / Q000378:metabolism; D004817:Epidermis / Q000201:enzymology / Q000528:radiation effects*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008297:Male; D008954:Models, Biological; D010084:Oxidation-Reduction / Q000528:radiation effects*; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase