[The effect of gamma-hydroxybutyric acid on the reaction rate of phosphate-containing metabolites in the rat brain during ischemia estimated from (31)P-NMR spectroscopic data].
Protective effects of gamma-hydroxybutyric acid on bioenergetic reactions were studied in brain of rats with ischemia using 31P-NMR spectroscopy in vivo. Intraperitoneal preadministration of gamma-hydroxybutyric acid at a dose of 400 mg/kg within 30-40 min before ischemia led to a decrease in the ATP pool in ischemic brain tissue, to alteration in the PCr/ATP ratio in the 31P-NMR spectrum, to prevention of Pi concentration increase and to increase in the intracellular acidosis development rate. Possible mechanisms of the gamma-hydroxybutyric acid effects on bioenergetic reactions in nervous tissue during ischemia are discussed.
Likhova
S S
SS
Likhodiĭ
S S
SS
Sibel'dina
L A
LA
D000138:Acidosis / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010759:Phosphorus Isotopes; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D009943:Organophosphorus Compounds; D010759:Phosphorus Isotopes; D005680:gamma-Aminobutyric Acid; D000255:Adenosine Triphosphate
Vliianie GOMK na tempy snizheniia makroérgicheskikh fosfatov mozga krys vo vremia ishemii po dannym prizhiznennoĭ (31)P-YaMR-spektroskopii.