Error filtration, interference, and the human linkage map.
Typing error is a major problem in constructing human linkage maps, leading to incorrect orders and inflating map lengths. An error filter is incorporated into multiple pairwise analysis that corrects for inflation of map lengths and improves recovery of the correct order. Multipoint mapping is more sensitive to error, but when its output is adjusted for both error and interference, map lengths are no longer inflated in proportion to the number of loci and are close to those obtained by multiple pairwise analysis.
Shields
D C
DC
Department of Community Medicine, University of Southampton, Southampton General Hospital, United Kingdom.
Collins
A
A
Buetow
K H
KH
Morton
N E
NE
D000465:Algorithms; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D003198:Computer Simulation; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008957:Models, Genetic; D009010:Monte Carlo Method