title: Human recombinant GM-CSF in allogeneic bone marrow transplantation for leukaemia: double-blind placebo controlled trial.
abstract: A double-blind randomised trial compared 20 patients with leukaemia receiving human recombinant granulocyte macrophage colony stimulating factor (GM CSF), with 20 patients receiving placebo for 14 days after allogeneic matched sibling bone marrow transplantation. The median neutrophil count at 14 days was significantly higher in the GM CSF group (1.90 vs. 0.46 x 10(9)/l). The duration of hospital stay, the number of antibiotic days, and the number of fever days was the same for both patient groups. The lymphocyte count was significantly higher in the GM-CSF group than in the placebo group between days 10 and 15 after transplantation. The GM-CSF group had lower haemoglobin concentrations and platelets counts, and higher plasma urea creatinine and bilirubin, than the placebo group. There was no evidence that GM CSF was associated with a greater incidence of leukaemic relapse.
authors.affiliation: Royal Marsden Hospital, Sutton.
authors.forename: R
authors.initials: R
authors.lastname: Powles
authors.forename: J
authors.initials: J
authors.lastname: Treleaven
authors.forename: J
authors.initials: J
authors.lastname: Millar
authors.forename: E C
authors.initials: EC
authors.lastname: Gordon-Smith
authors.forename: C
authors.initials: C
authors.lastname: Tiley
authors.forename: M
authors.initials: M
authors.lastname: Findlay
authors.forename: C
authors.initials: C
authors.lastname: Teo
authors.forename: A
authors.initials: A
authors.lastname: Duncombe
authors.forename: G
authors.initials: G
authors.lastname: Robinson
mesh_terms: D016026:Bone Marrow Transplantation; D004311:Double-Blind Method; D005334:Fever / Q000517:prevention & control; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology / Q000627:therapeutic use*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use*; D007902:Length of Stay; D007938:Leukemia / Q000601:surgery*; D007958:Leukocyte Count / Q000187:drug effects; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D006454:Hemoglobins; D007155:Immunologic Factors; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor