[Randomized study of amoxicillin-clavulanic acid versus amoxicillin-metronidazole combinations in pyogenic infections of dental origin].
Thirty patients, without any valve defect, cardiac malformation or previous antibiotic administration and presenting dental infections, have been treated either with amoxycillin-clavulanic acid or amoxycillin and metronidazole. Aerobic and anaerobic bacteria have been isolated. These infections were due to mixed flora. Nearly one half of anaerobes were Peptostreptococcus, S. milleri and S. sanguis being predominant among aerobes. The species identified were those found in the mouth in the absence of infection becoming as opportunistic flora. The percentage of cures was equivalent in the two groups. the association amoxycillin-clavulanic acid seems to be as active as amoxycillin + metronidazole on the microflora isolated from dentogenous pyogenic infections.
Chomarat
M
M
Laboratoire de Bactériologie, Centre Hospitalier Lyon-Sud, Pierre-Bénite.
Dubost
J
J
Kalfon
F
F
D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D010462:Peptostreptococcus / Q000302:isolation & purification; D011671:Pulpitis / Q000188:drug therapy / Q000382:microbiology; D013291:Streptococcus / Q000302:isolation & purification; D014076:Tooth Diseases / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D008795:Metronidazole; D019818:Clavulanic Acid; D000658:Amoxicillin
Etude randomisée de l'association amoxicilline-acide clavulanique versus amoxicilline + métronidazole dans les cellulites de la face d'origine dentaire.