title: Neuroimaging in lissencephaly type I.
abstract: The CT scan's of 22 patients with lissencephaly type I, a severe developmental disorder of the cerebral cortex, were studied. In 6 patients a magnetic resonance (MR), scan was also performed. The CT and MR scans of the lissencephaly patients were compared to a control group consisting of 49 patients with a normal CT or MR scan. In lissencephaly the cortical thickness was always larger than 10 mm, as compared to less than 7 mm in the normal situation. In lissencephaly the WSF/DSF index (with/depth of the sylvian fissure) was always larger than 0.29, while in the normal situation less than 0.25.
authors.affiliation: Department of Neurology, Westeinde Hospital, The Hague, The Netherlands.
authors.forename: J F
authors.initials: JF
authors.lastname: de Rijk-van Andel
authors.forename: M S
authors.initials: MS
authors.lastname: van der Knaap
authors.forename: J
authors.initials: J
authors.lastname: Valk
authors.forename: W F
authors.initials: WF
authors.lastname: Arts
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed