Transgenic approaches to modification of cell and tissue function.
The past 18 months have seen rapid advances in the use of transgenic techniques for elucidating cellular mechanisms. The modification of gene, cellular and tissue function has been enhanced by developments in the use of antisense and ribozyme constructs, and by improvements in strategies for cell ablation and homologous recombination.
Mullins
L
L
Centre for Genome Research, University of Edinburgh, UK.
Mullins
J
J
D000818:Animals; D030801:Animals, Genetically Modified; D003001:Cloning, Molecular; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D011995:Recombination, Genetic