The construction of biochemical reference ranges and the identification of possible adverse drug reactions in the elderly.
In the assessment of adverse drug reactions (ADRs) it is important to establish what is a normal range of values for a given biochemical measurement. Furthermore, such ranges need to be specific to the study population, for example, the elderly. A mixture of Gaussian distributions has been used in the construction of the reference ranges with maximum likelihood used to obtain estimates of the unknown parameters. With this approach, well-defined reference ranges have been established. Brief details are given of the numbers of ADRs identified in the study population using these ranges.
Lawrence
C J
CJ
Department of Mathematical Statistics and Operational Research, University of Exeter, U.K.
Trewin
V F
VF
D000368:Aged; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006454:Hemoglobins; D006801:Humans; D008297:Male; D011188:Potassium / Q000097:blood; D012016:Reference Values; D012964:Sodium / Q000097:blood; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D006454:Hemoglobins; D014508:Urea; D012964:Sodium; D003404:Creatinine; D001663:Bilirubin; D011188:Potassium