The effects of atropine or benzilonium on pelvic pouch and anal sphincter functions.
Anticholinergic drugs are used on an empirical basis for treatment of functional disturbances after restorative proctocolectomy, but their mode of action on ileal pouch performance is mainly unknown. We studied the acute effects of atropine or benzilonium on pouch characteristics and anal sphincter function in 20 patients with a pelvic pouch. Pouch volume was increased by 27% by atropine at distension with 20 cm H2O (p less than 0.01). Benzilonium tended to have a similar effect, but the changes did not reach statistical significance (p = 0.06). Pouch contractility, as reflected by volume fluctuations and pressure changes during distension, was almost abolished by both drugs. Sensory thresholds for sense of filling and, particularly, urge were raised. Resting anal pressure was slightly lowered, whereas no significant effect was found on maximal squeeze pressure. In conclusion, anticholinergics appear to have specific properties of action on small-intestinal reservoirs, constituting possible explanations for the empirically observed beneficial effects of anticholinergic treatment of functional disturbances after restorative proctocolectomy.
Hallgren
T
T
Dept. of Surgery II, University of Gothenburg, Sweden.
Fasth
S
S
Delbro
D
D
Nordgren
S
S
Oresland
T
T
Hultén
L
L
D000328:Adult; D001003:Anal Canal / Q000187:drug effects* / Q000601:surgery; D001285:Atropine / Q000009:adverse effects / Q000494:pharmacology*; D003082:Colectomy; D005260:Female; D006801:Humans; D007082:Ileum / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011312:Pressure; D012677:Sensation / Q000187:drug effects
D001285:Atropine