Molecular graphics applied to 5-HT3 ligands.
The recent surge of scientific interest in 5-hydroxytryptamine3 (5-HT3) receptors can be attributed largely to the rapid increase in the number of potent and selective 5-HT3 receptor antagonists. The availability of a large variety of chemically diverse 5-HT3 compounds allows for a unique opportunity to apply computer-based modelling techniques to the analysis of the 5-HT3 receptor pharmacophore. The present review summarises recent studies performed in this laboratory. The primary goal of these studies was to elucidate the chemical requirements needed for molecular recognition at the 5-HT3 receptor binding site. A secondary goal was to determine if this type of molecular information could be assessed using computerised chemical databases.
Peroutka
S J
SJ
Department of Neurology, Stanford University Medical Center, CA 94305-5235.
D003198:Computer Simulation; D016208:Databases, Factual; D008958:Models, Molecular; D011985:Receptors, Serotonin / Q000737:chemistry / Q000378:metabolism*; D012702:Serotonin Antagonists; D013329:Structure-Activity Relationship
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists