title: Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen.
abstract: Two propart peptides of aspartic proteinases, the propart peptide of chicken pepsin and human cathepsin D, respectively, were investigated from the point of view of their inhibitory activity for a set of aspartic proteinases. These peptides display a very broad inhibitory spectrum. The strongest inhibition was observed for pepsin A-like proteinases where propart peptides can be used as titrants of active enzymes.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague.
authors.forename: M
authors.initials: M
authors.lastname: Fusek
authors.forename: M
authors.initials: M
authors.lastname: Mares
authors.forename: J
authors.initials: J
authors.lastname: Vágner
authors.forename: Z
authors.initials: Z
authors.lastname: Voburka
authors.forename: M
authors.initials: M
authors.lastname: Baudys
mesh_terms: D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D002402:Cathepsin D / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002645:Chickens; D004792:Enzyme Precursors / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010434:Pepsin A / Q000037:antagonists & inhibitors; D010435:Pepsinogens / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000494:pharmacology*
chemical_list: D004792:Enzyme Precursors; D010435:Pepsinogens; D011480:Protease Inhibitors; D016282:Aspartic Acid Endopeptidases; C058345:procathepsin D; D010434:Pepsin A; D002402:Cathepsin D