Reversal of melphalan resistance in vivo and in vitro by modulation of glutathione metabolism.
Medh
R D
RD
Mercy Hospital Regional Oncology Center; Department of Medicine, University of Pittsburgh, PA.
Gupta
V
V
Awasthi
Y C
YC
D019328:Buthionine Sulfoximine; D002470:Cell Survival / Q000187:drug effects; D004351:Drug Resistance; D005978:Glutathione / Q000172:deficiency / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D008558:Melphalan / Q000494:pharmacology*; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives / Q000494:pharmacology; D009101:Multiple Myeloma / Q000378:metabolism* / Q000473:pathology; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000187:drug effects
D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D005982:Glutathione Transferase; D005978:Glutathione; D008558:Melphalan