Recovery of inter-block information in cross-over trials.
For cross-over designs, we show that one can recover information on direct and/or residual treatment effects from an inter-block (patients as blocks) analysis as is done in an incomplete block design. By combining the intra- and inter-block estimates, we obtain the generalized least squares estimate. In analysing cross-over trials, we recommended this approach provided the between-patient variance component can be estimated efficiently.
Chi
E M
EM
Marion Merrell Dow, Cincinnati, OH 45215.
D000547:Amantadine / Q000627:therapeutic use; D000704:Analysis of Variance; D001249:Asthma / Q000188:drug therapy; D002986:Clinical Trials as Topic / Q000379:methods*; D003627:Data Interpretation, Statistical; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D016018:Least-Squares Analysis; D015233:Models, Statistical; D010300:Parkinson Disease / Q000188:drug therapy
D000547:Amantadine