Glomerular lesions in spontaneously occurring diabetic WBN/Kob rats.
Glomerular lesions in WBN/Kob male rats with spontaneous diabetes were examined histopathologically. The glomerulopathy caused by diabetes was compared with lesions in chronic progressive nephropathy of non-diabetic SD and F344 male aged rats. Diffuse and global thickening of the mesangial area was observed only in WBN/Kob rats and showed a statistically significant correlation with serum glucose concentrations. Therefore, it suggested that the mesangial thickening was a result of hyperglycaemia. Fibrin cap-like lesions were seen in both WBN/Kob and non-diabetic SD or F344 male rats. The severity of these lesions was closely related to that of chronic progressive nephropathy and, therefore, the fibrin cap-like lesions were considered to be due to the chronic progressive nephropathy.
Tago
Y
Y
Mitsubishi Kasei Institute of Toxicological and Environmental Sciences, Ibaraki, Japan.
Katsuta
O
O
Tsuchitani
M
M
Narama
I
I
Itakura
C
C
D000367:Age Factors; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003928:Diabetic Nephropathies / Q000662:veterinary*; D004195:Disease Models, Animal; D005920:Glomerular Mesangium / Q000473:pathology*; D015433:Glomerulonephritis, Membranous / Q000662:veterinary*; D007668:Kidney / Q000473:pathology; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000097:blood / Q000473:pathology*
D001786:Blood Glucose