title: Molecular nature of aldosterone synthase, a member of cytochrome P-450(11 beta) family.
abstract: The molecular nature of the aldosterone synthesizing enzymes of cattle and rat is discussed. In bovine adrenal cortex, one molecular species of cytochrome P-450(11 beta) catalyzes aldosterone synthesis as well as 11 beta-hydroxylation. The intactness of the mitochondrial membrane surrounding P-450(11 beta) in the zonae fasciculata-reticularis is essential to keep the aldosterone synthesizing activity of the cytochrome in these zones latent. In rat adrenal cortex, two distinct molecules belonging to a P-450(11 beta) family exist. One is 11 beta-hydroxylase, and the other aldosterone synthase.
authors.affiliation: Department of Molecular Physiological Chemistry, Osaka University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nonaka
authors.forename: N
authors.initials: N
authors.lastname: Matsukawa
authors.forename: Z
authors.initials: Z
authors.lastname: Ying
authors.forename: T
authors.initials: T
authors.lastname: Ogihara
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D000818:Animals; D002417:Cattle; D019405:Cytochrome P-450 CYP11B2; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism / Q000648:ultrastructure; D015394:Molecular Structure; D051381:Rats; D013250:Steroid Hydroxylases / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology
chemical_list: D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; D019405:Cytochrome P-450 CYP11B2