title: Effects of indomethacin on cerebral hemodynamics at rest and during endotracheal suctioning in preterm neonates.
abstract: The effect of therapeutic doses of indomethacin versus placebo (saline) on cerebral hemodynamics was studied in nine mechanically ventilated preterm infants. Recordings were made at rest and during endotracheal suctioning. Indomethacin at a dose of 0.2 mg/kg body weight was infused over 5 min. Compared to placebo, there was a significant decrease in Doppler mean frequency in the anterior cerebral artery within minutes of starting the indomethacin infusion during the resting period after the first (p less than 0.01), second (p less than 0.001) and third (p less than 0.025) doses. This effect has persisted during endotracheal suctioning. Thus, indomethacin alters cerebral hemodynamics by decreasing Doppler mean frequency. In view of these findings, and particularly because of the alteration in the resting cerebral hemodynamics, the recommendation of prophylactic treatment with indomethacin remains questionable.
authors.affiliation: Unité INSERM 316, University of Tours, France.
authors.forename: E
authors.initials: E
authors.lastname: Saliba
authors.forename: A
authors.initials: A
authors.lastname: Chantepie
authors.forename: E
authors.initials: E
authors.lastname: Autret
authors.forename: F
authors.initials: F
authors.lastname: Gold
authors.forename: L
authors.initials: L
authors.lastname: Pourcelot
authors.forename: J
authors.initials: J
authors.lastname: Laugier
mesh_terms: D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy* / Q000503:physiopathology / Q000628:therapy; D015150:Echocardiography, Doppler; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D007442:Intubation, Intratracheal; D013396:Suction
chemical_list: D007213:Indomethacin