title: Treatment of constitutional growth delay in prepubertal boys with a prolonged course of low dose oxandrolone.
abstract: Forty six prepubertal boys who had constitutional growth delay were treated with oxandrolone. Mean age at the onset of treatment was 11.9 years (range 9.0-14.0) and bone age delay was 1.9 'years'. The dose of oxandrolone used was a mean of 0.05 mg/kg (range 0.03-0.18) for a mean of 0.9 years (range 0.2-3.6). Height velocity increased from a mean (SD) before treatment of 4.0 (1.0) to 7.5 (1.2) cm/year with oxandrolone. Growth rate was sustained at 7.6 (2.2) cm/year in the period after treatment. Those boys who attained a testicular volume of 4 ml or greater at the end of the treatment period had the most pronounced sustained growth acceleration. Height for bone age SD score did not alter significantly from a mean of -1.0 before treatment to -1.2 after treatment. Oxandrolone is a safe and effective treatment for prepubertal boys with constitutional growth delay.
authors.affiliation: Institute of Child Health, London.
authors.forename: A
authors.initials: A
authors.lastname: Papadimitriou
authors.forename: S
authors.initials: S
authors.lastname: Wacharasindhu
authors.forename: K
authors.initials: K
authors.lastname: Pearl
authors.forename: M A
authors.initials: MA
authors.lastname: Preece
authors.forename: R
authors.initials: R
authors.lastname: Stanhope
mesh_terms: D000293:Adolescent; D001827:Body Height; D002648:Child; D004334:Drug Administration Schedule; D006130:Growth Disorders / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010074:Oxandrolone / Q000008:administration & dosage / Q000627:therapeutic use*; D011627:Puberty
chemical_list: D010074:Oxandrolone