title: The effect of 2-O-stearoyl-glycerol 1,3-bisphosphate on the demineralization of dental enamel in vitro.
abstract: Parts of the buccal and lingual enamel surfaces of sound human third molars were treated with a test compound, and the non-treated parts served as control. After the treatment both parts were demineralized, and the artificial caries lesions were analyzed by means of quantitative microradiography. Treatment during only 1 minute with an aqueous solution of 1.5 mmol/l of the surface active compound 2-O-stearoyl-glycerol 1,3-bisphosphate (Glydip) resulted in a decrease in the rate of enamel demineralization by about 60%. When Glydip was dissolved in a toothpaste/water slurry it inhibited the demineralization by about 30%. When the enamel was covered by a salivary pellicle prior to the application of the slurry, the inhibition of the demineralization disappeared. However, when Glydip was applied in an aqueous solution, the presence of a salivary pellicle did not interfere with the decreasing effect of Glydip on the demineralization. It is concluded that Glydip has promising properties for its use as an anti-caries agent, in combination with fluoride.
authors.affiliation: Department of Biochemistry, University of Nijmegen, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Borggreven
authors.forename: I G
authors.initials: IG
authors.lastname: Pünt
authors.forename: R
authors.initials: R
authors.lastname: Gorissen
authors.forename: F C
authors.initials: FC
authors.lastname: Driessens
authors.forename: B
authors.initials: B
authors.lastname: Zwanenburg
authors.forename: T
authors.initials: T
authors.lastname: Hoeks
mesh_terms: D003731:Dental Caries / Q000503:physiopathology*; D003741:Dental Deposits / Q000503:physiopathology; D003743:Dental Enamel / Q000187:drug effects*; D044622:Dental Pellicle; D006801:Humans; D008852:Microradiography; D010742:Phospholipid Ethers / Q000008:administration & dosage / Q000494:pharmacology*; D012463:Saliva / Q000502:physiology; D012471:Salivary Proteins and Peptides / Q000494:pharmacology; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D010742:Phospholipid Ethers; D012471:Salivary Proteins and Peptides; D013501:Surface-Active Agents; C069963:Glydip