Exacerbation of doxorubicin toxicity by chlorpromazine in male ddY mice.
We examined whether chlorpromazine (CPZ) modulates the lethality of doxorubicin (DOX, 12 mg/kg, i.p.) in mice treated with CPZ (6 mg/kg, i.p.) 1 hr before administration of DOX. Pretreatment with CPZ produced: 1) earlier deaths and 2) an increase in the number of deaths, compared to the controls. Potentiation of the bone marrow toxicity of DOX by CPZ was also reflected in the drug lethality towards the animals.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D004317:Doxorubicin / Q000633:toxicity*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D004317:Doxorubicin; D002746:Chlorpromazine