The intracerebroventricularly administered mast cells degranulator compound 48/80 increases the pituitary-adrenocortical activity in rats.
The effect of brain mast cells degranulation by compound 48/80 on the pituitary-adrenocortical activity, measured indirectly through corticosterone secretion, and the involvement of a histaminergic mechanism in that stimulation was investigated in conscious rats. All the drugs were given intracerebroventricularly (icv), histamine antagonists 15 min prior to compound 48/80. Compound 48/80 induced a significant dose- and time-related increase in the serum corticosterone levels. That increase, measured 1 h after administration of compound 48/80, was moderately diminished by icv pretreatment of rats with mepyramine and cimetidine, histamine H1- and H2-receptor antagonists. Three hours after administration of compound 48/80 mast cells of the thalamus and the hypothalamus were completely degranulated. At the same time the thalamus and the whole brain histamine levels were substantially higher than in the saline-treated control rats. The above results suggest that histamine liberated from the brain mast cells and central histamine receptors play a moderate role in increasing the pituitary-adrenocortical activity by compound 48/80.
Gadek-Michalska
A
A
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Chłap
Z
Z
Turoń
M
M
Bugajski
J
J
Fogel
W A
WA
D000302:Adrenal Cortex / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002927:Cimetidine / Q000494:pharmacology; D003345:Corticosterone / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000502:physiology; D006632:Histamine / Q000378:metabolism; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects; D007700:Kinetics; D008297:Male; D008407:Mast Cells / Q000648:ultrastructure; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology*; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D003189:p-Methoxy-N-methylphenethylamine; D002927:Cimetidine; D006632:Histamine; D011738:Pyrilamine; D003345:Corticosterone