Temporal events regulating the early phases of the mammalian cell cycle.
It is proposed that the regulation of the pathways directing mammalian cell cycle progression involves several oncogenes. A summary of what is known about some of these regulatory oncogenes (fos, jun, myc, and Rb-1) and where they might function in the progression of a cell from G0 to G1 and G1 to S is presented. Data on two replication-dependent genes, those encoding histones and thymidine kinase, respectively, are also presented as models for describing transcriptional and post-transcriptional events at the G1-S border.
Naeve
G S
GS
University of Southern California School of Medicine, Los Angeles.
Sharma
A
A
Lee
A S
AS
D000818:Animals; D001483:Base Sequence; D002453:Cell Cycle / Q000235:genetics*; D004247:DNA; D016193:G1 Phase; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009857:Oncogenes; D016196:S Phase; D013937:Thymidine Kinase / Q000235:genetics
D006657:Histones; D004247:DNA; D013937:Thymidine Kinase