title: Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease.
abstract: The cellular distribution of nicotinic acetylcholine receptors was studied in the frontal cortex (area 10) of 1) Alzheimer patients and compared to 2) age-matched and 3) middle-aged controls using the monoclonal antibody WF 6 and an immunoperoxidase protocol. Statistical analysis revealed significant differences between the number of labeled neurons among all three groups tested (middle-aged controls greater than aged controls greater than Alzheimer cases). No differences were seen for cresyl violet-stained samples. These findings underline that the nicotinic receptor decrease found with radioligand binding may reflect a postsynaptic in addition to a presynaptic component.
authors.affiliation: Department of Pharmacology, Southern Illinois University School of Medicine, Springfield.
authors.forename: H
authors.initials: H
authors.lastname: Schröder
authors.forename: E
authors.initials: E
authors.lastname: Giacobini
authors.forename: R G
authors.initials: RG
authors.lastname: Struble
authors.forename: K
authors.initials: K
authors.lastname: Zilles
authors.forename: A
authors.initials: A
authors.lastname: Maelicke
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism*; D000911:Antibodies, Monoclonal; D048588:Benzoxazines; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010078:Oxazines; D011978:Receptors, Nicotinic / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D048588:Benzoxazines; D010078:Oxazines; D011978:Receptors, Nicotinic; C028911:cresyl violet