Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XIV: Branched aliphatic and alicyclic triamines and tetramines.
Twenty-four triamines and three tetramines were synthesized. Seventeen triamines inhibited platelet aggregation induced by collagen at a concentration below 10 mumol/L (IC50). Ten triamines in a 100 mumolar concentration inhibited fibrin formation induced by thromboplastin by more then 75%. Both effects do not run parallel. They are strongly dependent from the steric and lipophilic properties of the title oligoamines. The tetramines were nearly inactive.
Rehse
K
K
Institut für Pharmazie der Freien Universität Berlin.
Kesselhut
A
A
Schein
V
V
Leissring
S
S
D000925:Anticoagulants / Q000138:chemical synthesis*; D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*; D011073:Polyamines / Q000138:chemical synthesis* / Q000494:pharmacology
D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D011073:Polyamines