Effects of stanniectomy and experimental hypercalcemia on plasma calcium levels and calcium influx in American eels, Anguilla rostrata, LeSueur.
Intraperitoneal injection of CaCl2 in intact, sham-stanniectomized, and stanniectomized American eels, Anguilla rostrata (LeSueur), resulted in a rapid elevation of plasma calcium level which was more marked and of longer duration in the stanniectomized eels. The same treatment reduced whole body calcium influx (JinCa2+) in the intact and sham-stanniectomized groups for the first but not the second of two 4 hr flux periods. The same treatment did not affect JinCa2+ in the stanniectomized eels. We conclude that calcium loading in eels with intact stannius corpuscles (CS) results in the release of a CS hormone (stanniocalcin) which inhibits the uptake of calcium from the environment and that this facilitates the return to normocalcemia. These data provide direct evidence for a relationship between stanniocalcin release in vivo and a hypocalcemic response and the first evidence concerning the functional turnover time of this hormone.
Fenwick
J C
JC
Department of Biology, University of Ottawa, Ontario, Canada.
Brasseur
J G
JG
D000811:Anguilla / Q000097:blood*; D000818:Animals; D002118:Calcium / Q000097:blood* / Q000378:metabolism; D004702:Endocrine Glands / Q000502:physiology* / Q000601:surgery; D006023:Glycoproteins / Q000502:physiology; D006728:Hormones; D006934:Hypercalcemia / Q000378:metabolism
D006023:Glycoproteins; D006728:Hormones; C051795:teleocalcin; D002118:Calcium