title: A comparison of the withdrawal responses of heroin and methadone addicts during detoxification.
abstract: This study compares the withdrawal responses of methadone and heroin addicts during a ten-day in-patient detoxification programme with methadone. Contrary to suggestions in the literature, the methadone group reported more severe withdrawal symptoms during both the acute withdrawal phase and the recovery phase. There were no differences between the two groups in onset or duration of symptoms. Whereas there may be reasons to favour methadone as a maintenance drug, its use may lead to difficulties during withdrawal.
authors.affiliation: Drug Dependence Clinical Research and Treatment Unit, Bethlem Royal Hospital, Beckenham, Kent.
authors.forename: M
authors.initials: M
authors.lastname: Gossop
authors.forename: J
authors.initials: J
authors.lastname: Strang
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D003932:Heroin / Q000009:adverse effects*; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008691:Methadone / Q000009:adverse effects / Q000627:therapeutic use; D009460:Neurologic Examination; D009293:Opioid-Related Disorders / Q000534:rehabilitation*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
chemical_list: D003932:Heroin; D008691:Methadone