Increased cell number in remaining cerebellar nuclei after cerebellar hemispherectomy in neonatal rats.
After cerebellar hemispherectomy before the 10th day of life aberrant cerebello-rubral projections develop from the nuclei in the remaining hemisphere, which terminate on the ipsilateral side. These aberrant fibres stem from separate parent cells in the lateral and interposed nuclei. The problem addressed by the present study was whether the number of neurones in these nuclei is increased after early cerebellar hemispherectomy. Results demonstrate that the number of neurones was increased by 50-60%. The volumes of the nuclei were also increased (14-31%) but much less so, which indicates a relative decrease in neuropil per neuron.
Gramsbergen
A
A
Department of Developmental Neurology, State University of Groningen, The Netherlands.
IJkema-Paassen
J
J
D000818:Animals; D000831:Animals, Newborn; D002452:Cell Count; D002470:Cell Survival; D002529:Cerebellar Nuclei / Q000473:pathology*; D002531:Cerebellum / Q000601:surgery*; D004525:Efferent Pathways / Q000473:pathology; D008124:Locomotion / Q000502:physiology; D009474:Neurons / Q000473:pathology*; D051381:Rats; D012012:Red Nucleus / Q000473:pathology