[Clinical importance of determination of lipid peroxidation of erythrocyte membrane in children with mucoviscidosis].
The intensity of membranous red blood cell metabolism (lipid peroxidation /LPO/ and malonic dialdehyde /MDA/ metabolism) was examined in children suffering from mucoviscidosis depending on the gravity of the clinical manifestations of the disease. The membranopathological processes accompanied by different disorders of membranous metabolism, depending on the patient's status gravity and the intensity of inflammation in the respiratory organs were revealed. Based on the disagreement between different parameters that characterize LPO of red blood cells and MDA metabolism the conclusion is drawn that in children with mucoviscidosis, the metabolic processes occurring at the level of cellular membranes are not balanced. The data obtained point to the necessity of an individual approach to the use of membranoprotectors in multimodality treatment of children with mucoviscidosis together with the control over the treatment efficacy on the basis of a dynamic follow-up of membranous LPO with the aid of the method employed in the work.
Barbova
N I
NI
Kapranov
N I
NI
Bankova
V V
VV
Kozlova
S I
SI
D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male
D008054:Lipid Peroxides
Klinicheskoe znachenie opredeleniia perekisnogo okisleniia lipidov membran eritrotsitov pri mukovistsidoze u deteĭ.