Transepidermal water loss modifications in rats and humans treated with cyclosporin.
Modifications of transepidermal water loss (TEWL) of rat and human skin induced by oral administration of cyclosporin (CS) were investigated. The integrity of the cutaneous barrier was evaluated using TEWL measurement which is a relatively simple and noninvasive means of assessing the functional state of the cutaneous barrier. After 12 weeks, the TEWL of treated rats decreased significantly and this difference was still present after the 16 weeks of treatment. In humans, there was a statistically significant decrease of TEWL on both forearm and thigh in CS-treated patients compared to non-CS-treated patients and controls (p less than 0.05). These results suggest that CS causes skin modifications, particularly concerning its barrier status. The nature of these skin modifications still remains to be determined.
Doucet
O
O
Laboratoire de Pharmacologie, Unité de Dermopharmacologie, CNRS UA 594, Faculté de Pharmacie, Châtenay-Malabry, France.
Tidjani
A
A
Venencie
P Y
PY
Bismuth
H
H
Marty
J P
JP
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage / Q000494:pharmacology*; D004817:Epidermis / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D003524:Cyclosporins