title: [Adult T cell lymphoma/leukemia with alopecia, huge tumors of scalp and wide destruction of cerebral bone].
abstract: We reported rare manifestations of adult T cell lymphoma/leukemia. Patient was 41 year-old woman who has had progressive alopecia from childhood and developed multiple huge tumors (largest 10 x 15 cm) of scalp and wide destruction of cerebral bone at age of 39. A few abnormal lymphocytes (10%) appeared in the peripheral smear. Surface markers of peripheral lymphocytes showed two populations of CD4+/CD8- and CD4+/CD8+. HTLV-1 proviral DNA was demonstrated in the peripheral lymphocytes. Serum anti-ATLA antibodies was positive (X80). Biopsy of tumor revealed diffuse and large cell type of malignant lymphoma. Magnetic resonance imaging of head showed that tumors lysed the bone and invaded into cerebral regions. She was treated with CHOP regimen and irradiation, resulting of decreased tumor size and population of CD4+/CD8+.
authors.affiliation: Institute of Clinical Medicine, University of Tsukuba.
authors.forename: H
authors.initials: H
authors.lastname: Natsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Muraki
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Kozima
authors.forename: A
authors.initials: A
authors.lastname: Shibuya
authors.forename: T
authors.initials: T
authors.lastname: Nagasawa
authors.forename: T
authors.initials: T
authors.lastname: Abe
mesh_terms: D000328:Adult; D000505:Alopecia / Q000209:etiology*; D005260:Female; D006801:Humans; D015458:Leukemia, T-Cell / Q000150:complications / Q000473:pathology*; D012535:Scalp; D012878:Skin Neoplasms / Q000473:pathology*; D012888:Skull Neoplasms / Q000473:pathology*