title: The comparison of the efficacy among three different nimorazole regimens in the treatment of bacterial vaginosis.
abstract: The efficacy of 3 different nimorazole regimens in treating bacterial vaginosis in women was evaluated. The regimens consisted of: Nimorazole 2 g single dose (Group I), 1 g per day for 3 days (Group II), and 1 g per day for 7 days (Group III) orally. In a simple randomized trial of 90 cases (30 cases in each group) with demonstrated clinical bacterial vaginosis on the presence of 3 of 5 of the following signs: (1) Characteristic thin homogenous discharge; (2) vaginal pH greater than 4.5; (3) release of a fishy amine odor from vaginal fluid mixed with 10% KOH; (4) presence of clue cells (usually representing at least 20% of vaginal epithelial cells); and (5) vaginal fluid contains few or no lactobacilli. Cure rates for bacterial vaginosis by nimorazole were 70.0% (21/30), 83.3% (25/30), and 90.0% (27/30) in Group I, II, and III, respectively. Thus nimorazole is another effective drug for the treatment of bacterial vaginosis.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Thailand.
authors.forename: V
authors.initials: V
authors.lastname: Chandeying
authors.forename: S
authors.initials: S
authors.lastname: Sutthijumroon
authors.forename: S
authors.initials: S
authors.lastname: Tungphaisal
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D016009:Chi-Square Distribution; D004334:Drug Administration Schedule; D005260:Female; D006194:Gardnerella vaginalis; D006192:Haemophilus Infections / Q000188:drug therapy; D006801:Humans; D009554:Nimorazole / Q000008:administration & dosage*; D011897:Random Allocation; D014623:Vaginal Diseases / Q000188:drug therapy*
chemical_list: D009554:Nimorazole