[Susceptibility to miconazole (base) of isolates from the oral cavity and esophagus of patients with mycosis].
An antifungal agent of the imidazole class, miconazole (MCZ) (base), was investigated for its in vitro antifungal activities against isolates from the oral cavity and esophagus of patients with mycosis, and the following findings were obtained: 1. Those yeast-like fungi which were presumed to be the causative agents were isolated from the oral cavity and esophagus of patients with mycosis, and identified. Candida albicans was the most frequently occurring species, accounting for 71.4% of all the isolates. Less frequently, several other Candida species, such as Candida krusei, Candida tropicalis, Candida lusitaniae and Candida lipolytica were also isolated mostly from patients with polymicrobial infections. 2. The MICs of MCZ against the isolates of Candida species which were obtained from materials from patients with oral and esophageal candidiasis as the presumable causative agent distributed through such a wide range as less than or equal to 0.04 to 20 micrograms/ml, and susceptibilities of these isolates to MCZ proved to be no less than those to amphotericin B, which was used as the control drug. The results suggest that an appropriate preparation of MCZ (base) will be effective in treating mycosis of the oral cavity and esophagus.
Uchida
K
K
Research Center for Medical Mycology, Teikyo University School of Medicin.
Yamaguchi
H
H
D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology*; D002180:Candidiasis, Oral / Q000382:microbiology; D004935:Esophageal Diseases / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D008825:Miconazole