Selective 3-hydroxylation deficiency of lidocaine and its metabolite in Dark Agouti rats.
Selective and marked 3-hydroxylase deficiency of lidocaine and its N-deethylated metabolite, MEGX, were observed in male and female DA rats. These findings suggest that cytochrome P450 isozymes metabolizing debrisoquine may be involved in the 3-hydroxylations of lidocaine and MEGX in rats and humans.
Masubuchi
Y
Y
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Umeda
S
S
Chiba
M
M
Fujita
S
S
Suzuki
T
T
D000818:Animals; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006900:Hydroxylation; D008012:Lidocaine / Q000031:analogs & derivatives / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D003577:Cytochrome P-450 Enzyme System; D008012:Lidocaine; C001173:monoethylglycinexylidide; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6