title: Serum transferrin as a marker of bone growth in boys: correlation with serum alkaline phosphatase activity, plasma insulin-like growth factor 1 and rate of growth in height.
abstract: Transferrin (TF) has a growth promoting activity in cell culture. The aim of this work was to study possible relationships between serum TF, alkaline phosphatase activity (ALP), plasma insulin-like growth factor 1 (IGF-1) levels and rate of height increase in boys. 149 boys aged 13-15 yrs were studied. TF levels were measured using turbidimetric method. The serum levels of ALP could be used as a biochemical marker for bone formation. Significant correlation was found between serum TF levels and ALP levels (r = 0.31, P less than 0.0005). The TF levels are higher in iron-deficiency anemia. The hemoglobin (Hb) and serum ferritin were measured in all boys. Thirty-one of 149 boys had no iron-deficiency anemia (Hb 14.0 g/dl and serum ferritin 23 ng/ml). The rate of growth in height was estimated over a 5 month period. In these boys, the rate of growth in height was significantly correlated with serum TF levels (r = 0.37; P less than 0.05). A significant correlation was found between serum TF levels and plasma IGF-1 levels (r = 0.45; P less than 0.05). These data indicate that serum TF levels may be a marker of skeletal growth in normal boys.
authors.affiliation: Student Health Center, Mie University, Tsu, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Misaki
authors.forename: T
authors.initials: T
authors.lastname: Shima
authors.forename: Y
authors.initials: Y
authors.lastname: Yano
authors.forename: T
authors.initials: T
authors.lastname: Okazaki
mesh_terms: D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood*; D000747:Anemia, Hypochromic / Q000097:blood; D015415:Biomarkers; D001835:Body Weight / Q000502:physiology; D001846:Bone Development / Q000502:physiology*; D006128:Growth / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008297:Male; D009391:Nephelometry and Turbidimetry; D014168:Transferrin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D014168:Transferrin; D007334:Insulin-Like Growth Factor I; D000469:Alkaline Phosphatase