Protein kinase C in human pheochromocytoma.
Subtypes of protein kinase C were analyzed in adrenal and extra-adrenal pheochromocytoma of humans. Almost all protein kinase C of the adrenal tumor was type III, while the enzyme of the extra-adrenal tumor was separated into two major fractions corresponding to type II and type III by hydroxyapatite column chromatography. The extra-adrenal tumor but not the adrenal tumor spontaneously produced neurite-like processes when the cells were cultured in vitro. These results suggest that the high proportion of type II enzyme may reflect neuron-directed differentiation in human pheochromocytoma.
Koda
Y
Y
Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
Uezono
Y
Y
Kobayashi
H
H
Izumi
F
F
Inatomi
H
H
Yamada
Y
Y
Okamura
T
T
D000310:Adrenal Gland Neoplasms / Q000201:enzymology* / Q000473:pathology; D000328:Adult; D001369:Axons / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008858:Microscopy, Phase-Contrast; D008875:Middle Aged; D010673:Pheochromocytoma / Q000201:enzymology* / Q000473:pathology; D011493:Protein Kinase C / Q000145:classification / Q000378:metabolism*
D011493:Protein Kinase C