title: [Effect of low molecular weight regulators on the biosynthesis of rifamycin B by Amycolatopsis mediterranei strains].
abstract: Formation of differentiation regulators of the A-factor group in representatives of Nocardia and Nocardia-like actinomyces: N. asteroides, N. brasiliensis, Amycolatopsis mediterranei and "Streptomyces listeri" was observed. The effect of the regulators of different nature (barbital, A-factor and B-factor) on biosynthesis of rifamycin B by A. mediterranei strains was studied. It was shown that the A-factor stimulated rifamycin B production in the adifferentiated low active variant isolated from a natural population of the active strain VNIIA 1713 of the rifamycin B-producing culture. B-Factor insignificantly inhibited biosynthesis of rifamycin B in the studied strains of A. mediterranei.
authors.forename: O A
authors.initials: OA
authors.lastname: Bushueva
authors.forename: O V
authors.initials: OV
authors.lastname: Efremenkova
authors.forename: S E
authors.initials: SE
authors.lastname: Gorin
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Bartoshevich
mesh_terms: D000192:Actinomycetales / Q000378:metabolism*; D008970:Molecular Weight; D009615:Nocardia / Q000378:metabolism; D012294:Rifamycins / Q000096:biosynthesis*
chemical_list: D012294:Rifamycins; C033974:rifamycin B
vernacular_title: Vliianie nizkomolekuliarnykh reguliatorov na biosintez rifamitsina B shtammami Amycolatopsis mediterranei.