[Humoral cycle as a mechanism providing autoregulation of the processes of the immune system (theoretical model)].
The author presents a hypothesis on a possible mechanism of autoregulation of the immune response maturation in simulated influenza. A theoretical model describing a cyclic process of so-called "humoral cycle" which provides a directed selection of immunocompetent cells' clones and physiologic limitation of cytotoxic reactions. Possible features of humoral cycle function are considered in the concrete experimental examples. The author demonstrated possible mechanisms of immunological barrier violation in synthesis of big amounts of high affinity + antibodies to antigens of causative agent. Possible application of the theoretical model suggested in immunological studies is considered.
Voĭtsekhovskiĭ
B L
BL
D000818:Animals; D000915:Antibody Affinity / Q000276:immunology*; D000937:Antigen-Antibody Reactions / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D004195:Disease Models, Animal; D006706:Homeostasis; D051379:Mice; D009975:Orthomyxoviridae / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000382:microbiology
D000956:Antigens, Viral; D001323:Autoantibodies
Gumoral'nyĭ tsikl kak mekhanizm, obespechivaiushchiĭ avto- reguliatsiiu protsessov immunnoĭ zashchity (teoreticheskaia model').