Vitamin D metabolism in pre-operative extrahepatic biliary atresia.
In order to clarify the pathogenesis of rickets in preoperative patients with extrahepatic biliary atresia, we evaluated baseline serum 25-OHD and 1,25(OH)2D levels and correlated serum 25-OHD levels with increase in age and season of birth in 16 preoperative patients. Further, parenteral vitamin D2 tolerance tests were performed in 5 cases. Serum 25-OHD and 1,25(OH)2D levels were significantly lower than those in 15 normal controls. There was a negative correlation between the serum 25-OHD levels and increase in age. The patients born during the winter had lower serum 25-OHD concentrations than those born in summer. The mean value of increased 25-OHD levels after the parenteral vitamin D2 tolerance tests did not differ from that of 6 controls. Since there was no impairment of vitamin D 25-hydroxylation, the reduction in serum 25-OHD may therefore be mainly due to disturbed intestinal vitamin D absorption. It was also concluded that season of birth and increase in age are pathogenic factors in the etiology of rickets in preoperative patients with extrahepatic biliary atresia.
Tokita
A
A
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Nittono
H
H
Mori
T
T
Maruyama
T
T
Hayashi
M
M
Obinata
K
K
Watanabe
T
T
Yabuta
K
K
Miyano
T
T
D001656:Biliary Atresia / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007408:Intestinal Absorption; D008297:Male; D011300:Preoperative Care; D012279:Rickets / Q000209:etiology*; D012621:Seasons; D014807:Vitamin D / Q000378:metabolism*
D014807:Vitamin D; D002117:Calcitriol; D002112:Calcifediol