IgA nephropathy in non-cirrhotic portal hypertension.
Renal glomerular changes are a well recognised complication of cirrhosis and are frequently characterised by mesangial IgA deposition. We report a patient with non-cirrhotic portal hypertension who developed IgA nephropathy and a nephrotic syndrome with renal histological changes classically associated with cirrhosis. Splenectomy with resection of a splenic artery aneurysm resulted in remission of the nephrotic syndrome. This case illustrates the factors which contribute to the pathogenesis of IgA nephropathy in liver disease.
Babbs
C
C
University Department of Gastroenterology Manchester Royal Infirmary.
Warnes
T W
TW
Torrance
H B
HB
Ballardie
F W
FW
D000783:Aneurysm / Q000150:complications / Q000601:surgery; D002675:Child, Preschool; D005922:Glomerulonephritis, IGA / Q000209:etiology* / Q000473:pathology; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D008103:Liver Cirrhosis / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000473:pathology; D013156:Splenectomy; D013157:Splenic Artery