Cytogenetic surveillance of tobacco-areca nut (mava) chewers, including patients with oral cancers and premalignant conditions.
Three cytogenetic endpoints were studied in non-chewing healthy controls and 3 groups of tobacco-areca nut chewers, viz. normal chewers, chewers with oral submucous fibrosis and chewers with oral cancer. Frequencies of sister-chromatid exchanges and chromosome aberrations in peripheral blood lymphocytes and of micronucleated cells in exfoliated buccal mucosa were evaluated. All the parameters showed statistically significant elevations in all 3 groups of chewers compared to the controls. The data indicate possible application of the parameters as sensitive endpoints for monitoring tobacco-areca nut chewers, the group of individuals at higher risk of developing oral cancer, the commonest cancer among Indian males.
Adhvaryu
S G
SG
Department of Cancer Biology, Gujarat Cancer and Research Institute, Ahmedabad, India.
Dave
B J
BJ
Trivedi
A H
AH
D000293:Adolescent; D000328:Adult; D001114:Areca; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D015162:Micronucleus Tests; D009062:Mouth Neoplasms / Q000473:pathology*; D009152:Mutagenicity Tests; D010946:Plants, Medicinal; D010947:Plants, Toxic; D011230:Precancerous Conditions / Q000473:pathology*; D012854:Sister Chromatid Exchange; D014030:Tobacco, Smokeless / Q000009:adverse effects*