The diabetogenic and acidotropic effects of chelators.
Diabetogenic and acidotropic effects of dithizone, 8-(p-toluenesulfonylamino)-quinoline and 8-(benzenesulfonylamino)-quinoline were studied in experiments on cats, rabbits, golden hamsters and mice. Selective damage of insulin producing cells, phase glycemic fluctuations and permanent diabetes development were shown to be connected with chelator zinc binding in the lysosome-segregation apparatus of these cells.
Goldberg
E D
ED
Tomsk Scientific Center, U.S.S.R. Academy of Medical Sciences.
Eshchenko
V A
VA
Bovt
V D
VD
D000818:Animals; D001786:Blood Glucose; D002614:Chelating Agents / Q000494:pharmacology*; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000378:metabolism; D004230:Dithizone / Q000008:administration & dosage / Q000494:pharmacology*; D005455:Fluorescent Antibody Technique; D007275:Injections, Intravenous; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D008647:Mesocricetus; D051379:Mice; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology*
D001786:Blood Glucose; D002614:Chelating Agents; D007328:Insulin; D011804:Quinolines; D004230:Dithizone; D015032:Zinc