title: Effect of the interferone inducer, polyriboinosinic.polyribocytidylic acid on rat liver regeneration following partial hepatectomy.
abstract: The administration of the interferone inducer, polyriboinosinic.polyribocytidylic acid, inhibited the rise of activities of thymidylate synthase and thymidine kinase as well as DNA content in 24 h-regenerating rat liver in a dose dependent manner. The immunoblotting assay showed that the decrease of thymidylate synthase activity was due to inhibition of the induction of the enzyme. Co-administration of putrescine did not affect the inhibitory effect of polyriboinosinic.polyribocytidylic acid. Polyriboinosinic acid did not affect DNA synthesis in rat liver regeneration.
authors.affiliation: Department of Food Science and Nutrition, Nara Women's University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Tsukamoto
authors.forename: S
authors.initials: S
authors.lastname: Kojo
mesh_terms: D000818:Animals; D004261:DNA Replication / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D006498:Hepatectomy; D015151:Immunoblotting; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D011070:Poly I-C / Q000494:pharmacology*; D011700:Putrescine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013937:Thymidine Kinase / Q000378:metabolism; D013940:Thymidylate Synthase / Q000096:biosynthesis
chemical_list: D013940:Thymidylate Synthase; D013937:Thymidine Kinase; D011070:Poly I-C; D011700:Putrescine