[Studies on the antitumor antibiotic aclacinomycin A].
During the course of screening for new antitumor antibiotics, a new anthracycline antibiotic--aclacinomycin A was separated from the broth and mycelium of Streptomyces AC-57. The strain AC-57 was isolated from the soil collected in the Shanghai suburbs. According to its culture and physiological characteristics the producer was identified as Str. galilaeus AC-57. The broth and mycelium were extracted and treated with solvents as usual way. The aclacinomycin A was separated by silica-gel column chromatography eluted with chrolo-form-methanol. Aclacinomycin A, its aglycone and sugar components were identified by comparison of their physico-chemical and spectral data (MS, UV, IR, 1H-NMR, and 13C-NMR) with authentic compound, purified from the market sample.
Zhang
H
H
Shanghai Institute of Materia Medica, Academia Sinica, Shanghai.
Wang
D
D
Xu
S
S
Ye
Y
Y
Chen
P
P
D015250:Aclarubicin / Q000096:biosynthesis* / Q000737:chemistry; D013302:Streptomyces / Q000302:isolation & purification* / Q000378:metabolism
D015250:Aclarubicin