title: Distribution and excretion of 3H-sterigmatocystin in rats.
abstract: In order to investigate the distribution and excretion of sterigmatocystin, a carcinogenic mycotoxin, radioactively labelled compound was studied in rats. The highest concentration of radioactivity in serum appeared 3 h after administration of 0.5 microCi/g bw. The half-lives of distribution and excretion were 0.51 h and 43.9 h, respectively. The radioactivity was concentrated mainly in liver, stomach, kidney, duodenum and lung and to a lesser extent in fat, muscle, testis, rectum and bone. By 48 h, 56.4% had been excreted in faeces and 20.1% in urine. Biliary excretion may be the major route of excretion of sterigmatocystin.
authors.affiliation: Beijing Institute for Cancer Research, China.
authors.forename: D S
authors.initials: DS
authors.lastname: Wang
authors.forename: H L
authors.initials: HL
authors.lastname: Sun
authors.forename: F Y
authors.initials: FY
authors.lastname: Xiao
authors.forename: X H
authors.initials: XH
authors.lastname: Ji
authors.forename: Y X
authors.initials: YX
authors.lastname: Liang
authors.forename: F G
authors.initials: FG
authors.lastname: Han
mesh_terms: D000818:Animals; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013241:Sterigmatocystin / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014316:Tritium
chemical_list: D014316:Tritium; D013241:Sterigmatocystin