The use of 16.16-dimethyl-PGE1-delta-methyl ester (Cervagem) vaginal pessaries for cervical dilatation prior to evacuation for second trimester termination.
The results of a study of 101 consecutive second trimester terminations by Dilatation and Evacuation (D & E) under ultrasound control is presented. All had a Cervagem pessary inserted into the vagina prior to the procedure. The PGE1 analogue was assessed as 'effective' in 97% of patients. Concomitant ultrasound resulted in no patient leaving the operating table with retained products. The high efficacy of the single pessary associated with a low incidence of side-effects makes this combination the method of choice for nearly all second trimester terminations.
Bennett
M J
MJ
School of Obstetrics and Gynaecology, University of New South Wales.
Horrowitz
S D
SD
Wass
D M
DM
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000028:Abortion, Induced / Q000009:adverse effects / Q000379:methods*; D000293:Adolescent; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D004107:Dilatation and Curettage / Q000379:methods*; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D010570:Pessaries; D011183:Postoperative Complications; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage* / Q000009:adverse effects
D000020:Abortifacient Agents, Nonsteroidal; D011459:Prostaglandins E, Synthetic; C021182:gemeprost; D000527:Alprostadil