title: Transient cerebral ischaemic attacks and calcium-magnesium imbalance: clinical and paraclinical findings in 106 patients under 50 years of age.
abstract: One hundred and six selected patients (71 women, 35 men) suffering from transient cerebral ischaemic attacks (TIA) when aged less than 50 years received a comprehensive diagnostic assessment. Patients were classified into three subgroups, into which 9% could be assigned in approximately equal proportions. These were group A; TIA patients with tetanic syndrome (median age of first TIA 32 years, mainly female, 3.2 attacks per year and changing vascular area); group B; TIA patients with migraine (median age of first TIA 26 years, no predominance of male or female sex, 2.0 attacks per year and mostly in the same vascular area); group C: TIA patients suffering from premature arteriosclerosis (median age of first TIA 40 years, no predominance of male or female sex. 0.8 attacks per year and mostly in the same vascular area). Magnesium (P less than 0.001) and calcium (P less than 0.05) in plasma were reduced in group A, and magnesium (P less than 0.05) in group B, versus group C. The increased propensity to vasoconstriction appears to be an important pathogenic factor, particularly in group A, but also in group B.
authors.affiliation: Clinic and Outpatient Department of Neurology and Psychiatry, Humboldt University, Berlin, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Fauk
authors.forename: R
authors.initials: R
authors.lastname: Fehlinger
authors.forename: R
authors.initials: R
authors.lastname: Becker
authors.forename: E
authors.initials: E
authors.lastname: Meyer
authors.forename: C
authors.initials: C
authors.lastname: Kemnitz
authors.forename: B
authors.initials: B
authors.lastname: Reichmuth
authors.forename: A
authors.initials: A
authors.lastname: Stephan
mesh_terms: D000328:Adult; D001161:Arteriosclerosis / Q000150:complications / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D004569:Electroencephalography; D004584:Electronystagmography; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D050356:Lipid Metabolism; D008274:Magnesium / Q000378:metabolism* / Q000627:therapeutic use; D008297:Male; D013746:Tetany / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D008274:Magnesium; D002118:Calcium