title: Caffeinated and decaffeinated coffee effects on plasma lipoprotein cholesterol, apolipoproteins, and lipase activity: a controlled, randomized trial.
abstract: Coffee consumption has been associated with elevated plasma cholesterol. One hundred eighty-one men consumed a standard caffeinated coffee for 2 mo followed by randomization to continue caffeinated coffee (control), change to decaffeinated coffee or no coffee for 2 mo. Plasma low-density-lipoprotein (LDL) cholesterol and apolipoprotein B concentrations increased significantly (0.12 +/- 0.65 mmol/L, P less than 0.025; 0.06 +/- 0.12 g/L, P less than 0.0004, respectively) in the group that changed to decaffeinated coffee. In a subgroup (n = 51), post-heparin lipoprotein lipase decreased significantly more (-270 mmol free fatty acids.L-1.h-1, P less than 0.003) in the decaffeinated-coffee group. Resting heart rate and blood pressure did not change significantly. Change from caffeinated to decaffeinated coffee increased plasma LDL cholesterol and apolipoprotein B whereas discontinuation of caffeinated coffee revealed no change. This finding suggests that a coffee component other than caffeine is responsible for the LDL cholesterol, apolipoprotein B, and lipase activity changes reported in this investigation.
authors.affiliation: Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, CA.
authors.forename: H R
authors.initials: HR
authors.lastname: Superko
authors.forename: W
authors.initials: W
authors.lastname: Bortz
authors.forename: P T
authors.initials: PT
authors.lastname: Williams
authors.forename: J J
authors.initials: JJ
authors.lastname: Albers
authors.forename: P D
authors.initials: PD
authors.lastname: Wood
mesh_terms: D000328:Adult; D001053:Apolipoproteins / Q000097:blood*; D002110:Caffeine / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D003069:Coffee; D006801:Humans; D008049:Lipase / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012016:Reference Values
chemical_list: D001053:Apolipoproteins; D003069:Coffee; D008074:Lipoproteins; C030104:lipoprotein cholesterol; D002110:Caffeine; D002784:Cholesterol; D008049:Lipase