Mitotic control.
1990 has been a year of continued exciting developments in cell cycle control. Progress has occurred in delineating the mechanism of activation of maturation-promoting factor during entry into mitosis and the mechanism of cyclin degradation responsible for exit from mitosis. Notable advances have also occurred in our understanding of the dependence of mitotic entry on completion of DNA synthesis. Both genetic and biochemical data link this crucial checkpoint to the function of the cdc25 gene product and the extent of phosphorylation of Tyr15 in cdc2 kinase.
Maller
J L
JL
Howard Hughes Medical Institute University of Colorado School of Medicine, Denver 80262.
D000818:Animals; D016203:CDC2 Protein Kinase; D002453:Cell Cycle; D018797:Cell Cycle Proteins; D004261:DNA Replication; D005656:Fungal Proteins; D006801:Humans; D016200:Maturation-Promoting Factor; D008938:Mitosis; D011506:Proteins; D020687:cdc25 Phosphatases; D020666:ras-GRF1
D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D011506:Proteins; D020666:ras-GRF1; D016203:CDC2 Protein Kinase; D016200:Maturation-Promoting Factor; D020687:cdc25 Phosphatases