title: Approximate multinormal probabilities applied to correlated multiple endpoints in clinical trials.
abstract: Clinical trials with multiple endpoints incur increased familywise type I errors. The Bonferroni correction is a common method used to modify the p-values to account for multiple significance testing. For independent endpoints the Bonferroni method is slightly conservative whereas with high correlation the conservatism is extreme, as demonstrated by Pocock et al. This paper presents a procedure which allows for the correlation present, whilst adjusting the multiple p-values. The method is based on an approximation derived for multinormal probabilities.
authors.affiliation: Department of Mathematics, Leicester University, U.K.
authors.forename: S
authors.initials: S
authors.lastname: James
mesh_terms: D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D015999:Multivariate Analysis; D016011:Normal Distribution; D011336:Probability
chemical_list: D000959:Antihypertensive Agents