[The action of ribosomal preparations on nonspecific resistance to bacterial infection and on early tolerance to endotoxic shock].
Ribosomal preparations from Shigella flexneri and Shigella sonnei, introduced parenterally into mice, enhance their resistance to infection with the causative agents of typhoid fever and staphylococci. This effect is considerably less pronounced than that produced by the preparation of homologous lipopolysaccharide isolated by Boivin's method. After the administration of ribosomes nonspecific resistance to bacterial infective agents lasts for a short time. Ribosomal preparations do not enhance the resistance of mice to the lethal action of endotoxin.
Belkin
Z P
ZP
Levenson
V I
VI
Egorova
T P
TP
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology* / Q000302:isolation & purification; D004353:Drug Evaluation, Preclinical; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology / Q000302:isolation & purification; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012270:Ribosomes / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000517:prevention & control*; D012485:Salmonella typhi / Q000472:pathogenicity; D012763:Shigella flexneri / Q000276:immunology*; D012764:Shigella sonnei / Q000276:immunology*; D012772:Shock, Septic / Q000276:immunology / Q000517:prevention & control*; D013203:Staphylococcal Infections / Q000276:immunology / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000472:pathogenicity; D014774:Virulence
D001428:Bacterial Vaccines; D008070:Lipopolysaccharides
Deĭstvie ribosomal'nykh preparatov na nespetsificheskuiu rezistentnost' k bakterial'noĭ infektsii i ranniuiu tolerantnost' k éndotoksicheskomu shoku.