title: Splenic regeneration and phagocytic function after partial splenectomy in baboons.
abstract: Total splenectomy, especially in children, results in diminished ability to combat infection by capsulated bacteria. It is, however, uncertain how much splenic tissue is needed to maintain this ability. In this experimental study on baboons, in situ remnants after partial splenectomy were examined to evaluate regeneration and phagocytic function after injection of dual-labelled liposomes into their splenic arterial supply. The results showed that resection of as much as two-thirds of the spleen in baboons allowed sufficient regeneration to support adequate macrophage phagocytic function.
authors.affiliation: Department of Surgery, University of Stellenbosch, Parowvallel, CP.
authors.forename: L C
authors.initials: LC
authors.lastname: van Rensburg
authors.forename: S
authors.initials: S
authors.lastname: Kuhn
authors.forename: M B
authors.initials: MB
authors.lastname: Gemperli
authors.forename: J F
authors.initials: JF
authors.lastname: Klopper
authors.forename: A
authors.initials: A
authors.lastname: Ellman
authors.forename: S
authors.initials: S
authors.lastname: Theron
mesh_terms: D000818:Animals; D010215:Papio; D010587:Phagocytosis; D012038:Regeneration / Q000502:physiology*; D013154:Spleen / Q000276:immunology / Q000502:physiology*; D013156:Splenectomy