Proteinase-mediated cartilage degradation in osteoarthritis.
Osteoarthritis (OA) is a disease of complex etiology that results in articular cartilage breakdown. Current experimental evidence strongly suggests that proteinases may be involved in this loss of cartilage matrix. The present review summarizes the evidence for implicating proteinases in the etiopathogenesis of OA and suggests that blockade of proteinase activity may provide a rational basis for new therapeutic agents.
Dean
D D
DD
Arthritis Research Laboratory, US Veterans Administration Medical Center, Miami, FL 33125.
D002356:Cartilage / Q000378:metabolism* / Q000502:physiology; D010450:Endopeptidases / Q000502:physiology*; D006801:Humans; D010003:Osteoarthritis / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology
D010450:Endopeptidases