title: Who's on first? The U1 snRNP-5' splice site interaction and splicing.
abstract: U1 small nuclear ribonucleoprotein (snRNP) is important for pre-mRNA splicing both in yeast (Saccharomyces cerevisiae) and mammalian systems. The RNA component of U1 snRNP, U1 snRNA, interacts by base pairing with pre-mRNA 5' splice sites. This article examines recent evidence suggesting that U1 snRNP is important for an early step in spliceosome assembly rather than a late step that contributes to the specificity of 5' splice-site cleavage.
authors.affiliation: Howard Hughes Medical Institute, Department of Biology, Brandeis University, Waltham, MA 02254.
authors.forename: M
authors.initials: M
authors.lastname: Rosbash
authors.forename: B
authors.initials: B
authors.lastname: Séraphin
mesh_terms: D000818:Animals; D001483:Base Sequence; D005091:Exons; D007438:Introns; D008969:Molecular Sequence Data; D012326:RNA Splicing / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D012342:RNA, Small Nuclear / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D012342:RNA, Small Nuclear