Primary aldosteronism with cortisol overproduction from bilateral multiple adrenal adenomas.
A 55-year-old woman with bilateral multiple adenomas showed hypertension, muscle weakness, hypokalemia, moon-like face and truncal obesity. Increased serum and urinary levels of aldosterone were observed. Serum cortisol level did not show a normal circadian rhythm. Microscopic examination of the resected tumors showed two types of adenoma cells; one (golden yellow tumor) was a large clear cell with foamy cytoplasm which possibly secreted aldosterone and the other (dark brown tumor) was an acidophilic cell with lipofuscin which might have produced cortisol. This is a very rare case of primary aldosteronism with Cushing's syndrome due to multiple bilateral adrenal adenomas.
Nagae
A
A
Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
Murakami
E
E
Hiwada
K
K
Kubota
O
O
Takada
Y
Y
Ohmori
T
T
D000236:Adenoma / Q000097:blood / Q000150:complications* / Q000378:metabolism; D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000150:complications* / Q000378:metabolism; D003480:Cushing Syndrome / Q000097:blood / Q000209:etiology*; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D006929:Hyperaldosteronism / Q000097:blood / Q000209:etiology*; D007008:Hypokalemia / Q000209:etiology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000097:blood / Q000150:complications* / Q000378:metabolism; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D003907:Dexamethasone; D006854:Hydrocortisone