[Blood alcohol in relation to the presence of n-butyl acetate].
Adult female SPF rats (strain: Sprague-Dawley) were treated with 790 mg ethanol/kg body weight by intraperitoneal injection 30 minutes after the beginning of a 5-hr-inhalation of about 1,000 ppm n-butyl acetate in air via a tracheotomy tube (under urethane anesthesia). The elimination of the ethanol from blood which was increased to about 24 mmol/l (1.1%, g/v) was not delayed during the initial linear phase as compared to control (ethanol treatment without inhalation of n-butyl acetate). During inhalation approximately 24 mumol n-butyl acetate/l were measured in blood without ethanol treatment and approximately 52 mumol n-butanol/l as a metabolite of n-butyl acetate. The n-butanol content in blood was doubled under ethanol treatment. This increase is explained by substrate competition of both alcohols at the alcohol dehydrogenase with ethanol excess.
Groth
G
G
Institut für Pharmakologie und Toxikologie, Fakultät für Klinische Medizin Mannheim, Universität Heidelberg.
Freundt
K J
KJ
D000085:Acetates / Q000493:pharmacokinetics*; D000435:Alcoholic Intoxication / Q000097:blood*; D000818:Animals; D000431:Ethanol / Q000493:pharmacokinetics*; D005260:Female; D008657:Metabolic Clearance Rate / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D000431:Ethanol; C006848:butyl acetate
Blutalkohol unter Anwesenheit von n-Butylacetat.