title: [Successful treatment of non-Hodgkin's lymphoma with consciousness disturbance due to hypercalcemia by the calcium-free hemodialysis and combined chemotherapy].
abstract: A 63 year-old male, who was first diagnosed as primary macroglobulinemia (IgM-kappa type) developed non-Hodgkin's lymphoma after 10 month clinical course. He had huge, multiple intrahepatic nodular lesions and had consciousness disturbance due to marked hypercalcemia. Since the treatment with gluco-corticoid and calcitonin was not effective for the improvement of patient's general condition, calcium-free hemodialysis was performed. After 2-hour dialysis, serum-Ca level was decreased from 15. 2mg/dl to 10.0mg/dl. Histology of the aspiration biopsy specimen obtained from the liver showed malignant lymphoma, diffuse, large cell type (B cell origin). Combined chemotherapy (CHOP) was started and was quite effective not only for the regression of the primary lesions but also for the normalization of the serum-Ca level. The existence of PTH-like substance produced by the tumor cell was suspected and may be related to the hypercalcemia in this case. Finally, our results demonstrated that calcium-free hemodialysis is safe and highly effective for the management of hypercalcemia caused by malignancy.
authors.affiliation: Department of Medicine (II), Niigata University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Chou
authors.forename: H
authors.initials: H
authors.lastname: Inn
authors.forename: M
authors.initials: M
authors.lastname: Wakabayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Arakawa
mesh_terms: D002118:Calcium / Q000009:adverse effects / Q000097:blood; D003131:Combined Modality Therapy; D003244:Consciousness Disorders / Q000209:etiology; D004359:Drug Therapy, Combination; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000628:therapy*; D008099:Liver / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction / Q000379:methods; D006435:Renal Dialysis / Q000379:methods*; D014056:Tomography, X-Ray
chemical_list: D002118:Calcium