title: Evaluation of once-daily levobunolol 0.25% and timolol 0.25% therapy for increased intraocular pressure.
abstract: In a three-month, double-masked, randomized clinical trial, we evaluated the once-daily ocular hypotensive efficacy of 0.25% levobunolol and 0.25% timolol in 80 patients with open-angle glaucoma or ocular hypertension. Thirty-seven of the 39 patients (95%) in the 0.25% levobunolol group and 35 of the 41 patients (85%) in the 0.25% timolol group successfully completed the three-month study period. The overall mean decrease in intraocular pressure was 5.3 mm Hg (22%) in the 0.25% levobunolol group and 5.4 mm Hg (22%) in the 0.25% timolol group. This difference was not statistically significant. In both treatment groups, effects on mean heart rate and blood pressure were minimal. The data suggest that levobunolol 0.25% and timolol 0.25%, administered once daily, are equally effective in the treatment of open-angle glaucoma and ocular hypertension.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: D
authors.initials: D
authors.lastname: Silverstone
authors.forename: T
authors.initials: T
authors.lastname: Zimmerman
authors.forename: N
authors.initials: N
authors.lastname: Choplin
authors.forename: T
authors.initials: T
authors.lastname: Mundorf
authors.forename: A
authors.initials: A
authors.lastname: Rose
authors.forename: J
authors.initials: J
authors.lastname: Stoecker
authors.forename: E
authors.initials: E
authors.lastname: Kelley
authors.forename: J
authors.initials: J
authors.lastname: Lue
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005069:Evaluation Studies as Topic; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D002040:Levobunolol / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy; D009883:Ophthalmic Solutions; D013999:Timolol / Q000627:therapeutic use*
chemical_list: D009883:Ophthalmic Solutions; D013999:Timolol; D002040:Levobunolol