Acute cocaine administration: effects on local cerebral blood flow and metabolic demand in the rat.
Local cerebral blood flow and glucose utilisation were measured in both saline (n = 10) and cocaine (10 mg/kg; n = 10) treated rats using [14C]iodoantipyrine and [14C]2-deoxyglucose quantitative autoradiography respectively. In control animals, the ratio of flow to metabolism was 1.40 (r = 0.92) for the 40 brain regions examined. Cocaine treatment altered neither the correlation (r = 0.83) nor the ratio (1.49). Thus, the fundamental relationship between CBF and metabolism remains intact following acute cocaine exposure.
Sharkey
J
J
Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Scotland, U.K.
McBean
D E
DE
Kelly
P A
PA
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003847:Deoxyglucose / Q000378:metabolism*; D004334:Drug Administration Schedule; D009043:Motor Activity / Q000187:drug effects; D009928:Organ Specificity; D051381:Rats; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects
D001786:Blood Glucose; D003847:Deoxyglucose; D003042:Cocaine; D000983:Antipyrine; C008135:iodoantipyrine