Postnatal development of acetohexamide reductase activities in microsomes and cytosol of rat liver.
The postnatal development of acetohexamide reductase activities in liver microsomes and cytosol were examined in male rats. The developmental pattern of acetohexamide reductase activity in liver microsomes was distinguished from that in liver cytosol. Furthermore, acetohexamide reductase activity in liver microsomes was effectively suppressed by castration, but the activity in liver cytosol was not affected by castration. These results clearly indicate that enzymes with physiologically different roles can catalyze the metabolic reduction of acetohexamide in rat liver.
Imamura
Y
Y
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Torigoe
M
M
Yanachi
Y
Y
Higuchi
T
T
Otagiri
M
M
D000367:Age Factors; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D008099:Liver / Q000201:enzymology* / Q000254:growth & development; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000502:physiology
D000429:Alcohol Oxidoreductases; C064152:acetohexamide reductase