title: Induced hypertension during restoration of flow after temporary middle cerebral artery occlusion in the rat: effect on neuronal injury and edema.
abstract: The effect of hypertension instituted during restoration of flow after focal ischemia was studied. After the middle cerebral artery (MCA) of 12 rats was occluded for 2 hours, the ligatures were released and flow was restored for a period of 2 hours. In the control group, mean arterial pressure (MAP) was not manipulated. In the hypertensive group, the MAP was elevated by 25-30 mm Hg immediately after reestablishment of MCA patency. The area of neuronal injury, determined by 2,3,5-triphenyltetrazolium staining, was significantly smaller in the hypertensive group. Specific gravity, determined by microgravimetry, did not differ between groups. The data demonstrate that modest hypertension, when induced during reperfusion after 2 hours of MCA occlusion, reduces neuronal injury and does not exacerbate edema formation.
authors.affiliation: Neuroanesthesia Research, University of California, San Diego, La Jolla 92093.
authors.forename: P M
authors.initials: PM
authors.lastname: Patel
authors.forename: J C
authors.initials: JC
authors.lastname: Drummond
authors.forename: D J
authors.initials: DJ
authors.lastname: Cole
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001929:Brain Edema / Q000209:etiology / Q000517:prevention & control*; D002536:Cerebral Arteries / Q000503:physiopathology; D003250:Constriction; D005070:Evans Blue; D006973:Hypertension; D002546:Ischemic Attack, Transient / Q000150:complications* / Q000503:physiopathology; D010656:Phenylephrine / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR; D015427:Reperfusion Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D013778:Tetrazolium Salts
chemical_list: D013778:Tetrazolium Salts; D010656:Phenylephrine; D005070:Evans Blue; C009591:triphenyltetrazolium