title: The relationship between recent cocaine use and pregnancy outcome.
abstract: We conducted urine screening for cocaine metabolite in 500 consecutive women admitted to a labor and delivery unit. The pregnancy outcome of 411 of the women was determined at that admission. The prevalence of cocaine-positive urines was 15.3% (95% confidence interval 11.8-18.8%). A subset of this population that had not received prenatal care had a prevalence of 62% (95% confidence interval 47.2-76.6%). Women with positive urines were almost four times more likely to have preterm labor and over twice as likely to deliver a premature infant or one with a 1-minute Apgar score of 6 or lower. Our findings support the concept that urine drug screening for cocaine and/or other drugs of abuse should be considered in patients who present with no prenatal care, premature labor, premature delivery, and delivery of an infant with a 1-minute Apgar score of 6 or less. This strategy may enable us to identify and bring to therapy a population of women that could potentially go unrecognized.
authors.affiliation: Department of Obstetrics and Gynecology, Hahnemann University School of Medicine, Philadelphia, PA.
authors.forename: M R
authors.initials: MR
authors.lastname: Spence
authors.forename: R
authors.initials: R
authors.lastname: Williams
authors.forename: G J
authors.initials: GJ
authors.lastname: DiGregorio
authors.forename: A
authors.initials: A
authors.lastname: Kirby-McDonnell
authors.forename: M
authors.initials: M
authors.lastname: Polansky
mesh_terms: D000328:Adult; D001034:Apgar Score; D003042:Cocaine / Q000652:urine; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000453:epidemiology*; D015143:Philadelphia / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011295:Prenatal Care; D015995:Prevalence; D012307:Risk Factors; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D003042:Cocaine