Effect of local hemostatics on platelet aggregation.
The platelets play an important role in the normal hemostasis, and it is known that both natural and synthetic macromolecules may induce platelet activation and aggregation. Thus, the purpose of the present study was to investigate the platelet aggregating effect of five different local hemostatics. Platelet aggregation was assessed by aggregometry. Unwoven fleece of bovine collagen polymer in fibrillar form induced aggregation in combination with small amounts of platelet agonists; ADP and adrenaline. Ordinary, nonabsorbable bone wax also induced aggregation in combination with the agonists, but larger concentrations of agonists were needed. Bioerodible polyorthoester with physical properties such as bone wax, oxidized cellulose and gelatin sponge did not promote platelet aggregation.
Solheim
E
E
Department of Biochemistry, University of Bergen, Norway.
Anfinsen
O G
OG
Holmsen
H
H
Sudmann
E
E
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D002482:Cellulose / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D004338:Drug Combinations; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005780:Gelatin / Q000494:pharmacology; D006490:Hemostatics / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010168:Palmitates / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011091:Polyesters / Q000494:pharmacology; D014885:Waxes / Q000494:pharmacology
D004338:Drug Combinations; D006490:Hemostatics; D010168:Palmitates; D011091:Polyesters; D014885:Waxes; D000244:Adenosine Diphosphate; C055480:bone wax; D005780:Gelatin; D002482:Cellulose; D003094:Collagen; D004837:Epinephrine