Multisystem failure and hepatic microvesicular fatty metamorphosis associated with tolmetin ingestion.
Multisystem toxicity including both renal and hepatic failure has been reported with the use of nonsteroidal anti-inflammatory drugs. We report a fatal case of multisystem failure associated with tolmetin ingestion in a 15-year-old girl. Microvesicular fatty change was found in the liver at autopsy. To our knowledge, this is the first reported case of nonsteroidal anti-inflammatory drug-associated multisystem failure to have this histopathologic finding.
Shaw
G R
GR
Department of Pathology and Laboratory Medicine, Hennepin County Medical Center, Mineapolis, Minn. 55415.
Anderson
W R
WR
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000188:drug therapy; D001808:Blood Vessels / Q000473:pathology; D005234:Fatty Liver / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008102:Liver Circulation; D008833:Microcirculation; D009102:Multiple Organ Failure / Q000139:chemically induced*; D014046:Tolmetin / Q000009:adverse effects*
D014046:Tolmetin