[Toxic damage of kidney, liver and muscle attributed to the administration of germanium-lactate-citrate].
The case history is described of a woman aged 57 years with renal, hepatic and muscular damage attributed to intake of germanium lactate-citrate (a cumulative dose of 32.1 g germanium) over at least one year, as alternative treatment of metastatic breast cancer. Histological examination of biopsies showed highly vacuolated cytoplasm of the epithelial cells of the distal renal tubules and micro- and macrovesicular steatosis of centrilobular hepatocytes. After discontinuation of the germanium, serum aminotransferases and creatine kinase values returned to normal, but moderately severe renal impairment persisted.
Van der Spoel
J I
JI
Afd. Interne Geneeskunde, Onze Lieve Vrouwe Gasthuis, Amsterdam.
Stricker
B H
BH
Schipper
M E
ME
de Bruijn
W
W
de Smet
P A
PA
Esseveld
M R
MR
D001943:Breast Neoplasms / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002951:Citrates / Q000009:adverse effects; D000529:Complementary Therapies; D005260:Female; D005857:Germanium / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007773:Lactates / Q000009:adverse effects; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects*
D002951:Citrates; D007773:Lactates; D005857:Germanium
Toxische beschadiging van nier, lever en spier toegeschreven aan het gebruik van germanium-lactaat-citraat.