title: [The conservative treatment of carcinoma in situ of the cervix uteri by the local application of 5-fluorouracil].
abstract: Local treatment with 5% of 5-Fluorouracil (5-Fu) in the form of globules was carried out on 37 patients with carcinoma in situ of the uterine cervix, established histologically, as the application was performed once daily for a period of 14-20 days. There was a complete correlation between the cytological investigation after the conservative treatment and the histological examination of the operative material from the conization, which was made within 1-2 weeks after local application of 5-Fu. It could be possible to use cytology for objective determination of the therapeutic effect as well as a possible usage of colposcopic-directed biopsy. The conservative treatment with 5-Fu should be the first stage of treatment of these patients, but in the absence of therapeutic effect conization of the uterine cervix should be made, which reduces the risk of spontaneous abortion. The conservative treatment with local application of 5% of 5-Fu is recommended in young women, with not large lesions of carcinoma in situ of the uterine cervix and still at their reproductive age.
authors.forename: G
authors.initials: G
authors.lastname: Chakalova
authors.forename: A
authors.initials: A
authors.lastname: Karag'ozov
authors.forename: L
authors.initials: L
authors.lastname: Marinova
authors.forename: Ts
authors.initials: Ts
authors.lastname: Ralcheva
mesh_terms: D000287:Administration, Topical; D000328:Adult; D001706:Biopsy; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology; D003127:Colposcopy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D005472:Fluorouracil
vernacular_title: Konservativno lechenie na kartsinom in situ na matochnata shiĭka s lokalno aplitsirane na 5-fluorouracil.