title: Skeletal muscle density: effects of obesity and non-insulin-dependent diabetes mellitus.
abstract: Obesity is associated with increased lean mass but its effects on lean-tissue density are less clear. To examine the effects of obesity and non-insulin-dependent diabetes mellitus (NIDDM) on lean-tissue composition and density, cross-sectional computed tomography (CT) scans of the midthigh were obtained in 20 men of various weights. Obesity was associated with increases in thigh-adipose (r = 0.75) and lean-tissue volumes (r = 0.52) and with reduced density of lean tissue (r = -0.73). The increased lean tissue in obesity was due to a nonadipose tissue component with a density below the normal range of muscle, an effect compounded by NIDDM, whereas normal-density muscle volume was unchanged.
authors.affiliation: Department of Medicine, University of Pittsburgh School of Medicine, PA 15261.
authors.forename: D E
authors.initials: DE
authors.lastname: Kelley
authors.forename: B S
authors.initials: BS
authors.lastname: Slasky
authors.forename: J
authors.initials: J
authors.lastname: Janosky
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging; D015992:Body Mass Index; D001835:Body Weight; D003920:Diabetes Mellitus / Q000000981:diagnostic imaging*; D003924:Diabetes Mellitus, Type 2; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000000981:diagnostic imaging*; D009765:Obesity; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed