A tail length modifier gene discovered in the Japanese wild mice (Mus musculus molossinus).
The presence of the t haplotypes in strains derived from the Japanese wild mice (Mus musculus molossinus) was investigated. Crosses between the T/+ heterozygous short tailed mice and five normal tailed molossinus strains (MOL-ANJ, MOA, MOL-NEM, MOM and Mns) produced no tailless mice, indicating that these strains possess no t haplotype. In contrast, tailless mice were produced by a cross between the T/+ heterozygotes and a MOL-NIS strain. Mating experiments showed that the tailless character was due to an interaction between the T gene and an autosomal recessive gene carried by the MOL-NIS strain that expresses the short tail character under the homozygous condition. We have tentatively named this gene brachyury-interacting tail length modifier (btm). It remains to be investigated whether the btm gene is located in the t complex region or in the other locus.
Fujimoto
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A
Laboratory of Animal Genetics, School of Agriculture, Nagoya University, Japan.
Baba
N
N
Wakasugi
N
N
D000818:Animals; D005838:Genotype; D006239:Haplotypes; D006579:Heterozygote; D051379:Mice / Q000033:anatomy & histology / Q000235:genetics*; D013623:Tail / Q000033:anatomy & histology*