title: Robust trend analysis in predicting histamine provocation concentration.
abstract: Trend analysis is used to predict the histamine provocation concentration PC20 during the so-called challenge test, where increasing doses of the bronchoconstricting agent are given to a patient and the spirometric examination is subsequently performed. Classical least-squares analysis of trends as well as least absolute deviations analysis are compared. The results are interesting and promising from a statistical as well as medical point of view. The methods presented can be applied to many practical problems in medicine.
authors.affiliation: Institute of Computer Science, University of Wrocław, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Krusińska
authors.forename: J
authors.initials: J
authors.lastname: Liebhart
authors.forename: M
authors.initials: M
authors.lastname: Woźniak
mesh_terms: D000465:Algorithms; D001249:Asthma / Q000175:diagnosis*; D001985:Bronchial Provocation Tests; D005541:Forced Expiratory Volume / Q000187:drug effects; D006632:Histamine; D006801:Humans; D016018:Least-Squares Analysis; D011237:Predictive Value of Tests
chemical_list: D006632:Histamine