[Neurologic complications after bone marrow transplantation].
The retrospective study presented here reports clinical, electrophysiological and CT-data from 21 patients who underwent bone marrow transplantation for leukemia or aplastic anemia between 1980 and 1985. The aim of the investigation, which was performed at the end of 1986, was to elucidate whether antineoplastic drugs and radiation can result in long-term damage of the central nervous system. In 9 patients we observed neurological signs (1 leukencephalopathy, 5 cerebellar symptoms). Seven patients revealed dysrhythmia in the EEG and five had delayed latencies of visual evoked potentials. Eight patients exhibited pathological changes in CT (3 atrophy of supratentorial structures, 3 periventricular lucencies, 2 a combination of both). The results indicate that long-term damage to the CNS may be encountered after successful bone marrow transplantation.
Diener
H C
HC
Abteilung Allgemeine Neurologie, Neurologische Universitäts-Klinik, Universität Tübingen.
Ehninger
G
G
Schmidt
H
H
Stäb
U
U
Majer
K
K
Marquardt
B
B
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000601:surgery*; D016026:Bone Marrow Transplantation; D001921:Brain / Q000187:drug effects / Q000528:radiation effects; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis*; D002648:Child; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000175:diagnosis; D004569:Electroencephalography / Q000187:drug effects / Q000528:radiation effects; D005074:Evoked Potentials, Visual / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D006801:Humans; D007938:Leukemia / Q000601:surgery*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000175:diagnosis*; D011832:Radiation Injuries / Q000209:etiology; D013116:Spinal Cord / Q000187:drug effects / Q000528:radiation effects; D014057:Tomography, X-Ray Computed; D014916:Whole-Body Irradiation / Q000009:adverse effects
D008727:Methotrexate
Neurologische Komplikationen nach Knochenmarktransplantation.