title: Chromosome abnormalities in breast fibroadenomas.
abstract: A cytogenetic study on 25 breast fibroadenomas from 17 women is reported. Seven tumors in five patients showed clonal structural chromosome changes. In three patients the breaks involved chromosome 12, occurring in two tumors in band 12p12 and in band 12q15 in all three tumors of one patient. The finding of an identical aberration, t(11;12)(q21;q15), in three adenomas from the same patient strongly suggests a clonal origin of multiple fibroadenomas of the breast.
authors.affiliation: Istituto di Biologia, Universitá di Chieti, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Calabrese
authors.forename: C
authors.initials: C
authors.lastname: Di Virgilio
authors.forename: E
authors.initials: E
authors.lastname: Cianchetti
authors.forename: P
authors.initials: P
authors.lastname: Guanciali Franchi
authors.forename: L
authors.initials: L
authors.lastname: Stuppia
authors.forename: G
authors.initials: G
authors.lastname: Parruti
authors.forename: P G
authors.initials: PG
authors.lastname: Bianchi
authors.forename: G
authors.initials: G
authors.lastname: Palka
mesh_terms: D000232:Adenofibroma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D014178:Translocation, Genetic