[Immunohistochemical characteristics of the epithelial transformation zone in the uterine cervix using monoclonal antibodies against various epithelial markers].
Epithelium transformation zone in the uterine cervix was studied by means of monoclonal antibodies (MAB) against cytokeratin (CK) peptides, epithelial membrane antigen (EMA) and skin granular layer proteins. It is shown that in the region of epithelial junction metaplastic epithelium is, as a rule, observed which possesses a unique spectrum of CK distinct from that in the ecto--and endocervix. The features of the expression of CK N8, N17, EMA in metaplasia are described. MAB EE 2I-06 against CK N1, 2, 9-11 and MAB G 36-19 are suggested as markers of the metaplastic epithelium maturity in the uterine cervix.
Petrov
S V
SV
Raĭkhlin
N T
NT
Serre Dzh
D000328:Adult; D000911:Antibodies, Monoclonal; D015415:Biomarkers / Q000737:chemistry; D002584:Cervix Uteri / Q000737:chemistry*; D004848:Epithelium / Q000737:chemistry; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
D000911:Antibodies, Monoclonal; D015415:Biomarkers
Immunogistokhimicheskaia kharakteristika zony transformatsii épiteliia sheĭki matki s pomoshch'iu monoklonal'nykh antitel k razlichnym épitelial'nym markeram.