title: Deformation of the distal femur: a contribution towards the pathogenesis of osteochondrosis dissecans in the knee joint.
abstract: Osteochondrosis dissecans (OD) is a process of subchondral bone necrosis occurring predominantly in young individuals at specific sites. The aetiology of this disease remains controversial with mechanical processes due to trauma and/or ischaemic factors being proposed. This study aims at explaining the aetiology of OD in the knee joint as a result of the particular deformation of the condyles. A finite element analysis of the distal third of the femur was performed. A three-dimensional model was developed based on computed tomography scans of a normal femur, consisting of cortical bone, cancellous bone and articular cartilage. This model was subjected to physiological loads at 0, 30, 60 and 90 degrees of knee flexion. A complex deformation was found within each condyle as well as between the two condyles. Both medial and lateral condyles are deformed in the medio-lateral direction and at the same time compressed between the patella and the tibia in the antero-posterior direction. This effect is highest at 60 degrees of knee flexion. In both planes, the medial condyle is distorted more than the lateral one. Strain concentration in the subchondral bone facing the patella varies with flexion, especially for angles exceeding 60 degrees. The deformation of the femur in the predominant locus of OD in the medial condyle exceeds that of the lateral condyle considerably. The analysis shows that repeated vigorous exercise including extreme knee flexion may produce rapidly changing strains which in turn could ultimately be responsible for local subchondral bone collapse.
authors.affiliation: M.E. Müller-Institute for Biomechanics, University of Bern, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Nambu
authors.forename: B
authors.initials: B
authors.lastname: Gasser
authors.forename: E
authors.initials: E
authors.lastname: Schneider
authors.forename: W
authors.initials: W
authors.lastname: Bandi
authors.forename: S M
authors.initials: SM
authors.lastname: Perren
mesh_terms: D001696:Biomechanical Phenomena; D005269:Femur / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000503:physiopathology; D008954:Models, Biological; D009068:Movement / Q000502:physiology; D010008:Osteochondritis Dissecans / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D013314:Stress, Mechanical; D014057:Tomography, X-Ray Computed