Regulation of gene expression.
A fundamental tenet of biology is that the phenotype of an organism is ultimately determined by its complement of genes. In multicellular organisms, it is the regulated pattern of expression of genes which determines the proliferation and differentiation of individual cell lineages and hence establishes the adult phenotype. It is therefore no surprise that both neoplasia and many developmental pathologies involve lesions in the regulation of specific genes. For this reason, an understanding of how genes are regulated has become an area of intense interest in both medicine and biology.
Evan
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Imperial Cancer Research Laboratories, St. Bartholomew's Hospital, London, UK.
D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D005057:Eukaryotic Cells; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D014157:Transcription Factors
D014157:Transcription Factors