title: Preoperative evaluation of osteosarcoma: value of gadopentetate dimeglumine-enhanced MR imaging.
abstract: Decisions regarding the surgical approach in osteosarcoma require accurate assessment of tumor extent. In order to determine whether enhancement with gadopentetate dimeglumine could add clinically significant information to that available with unenhanced MR imaging, 21 patients with osteosarcoma underwent preoperative MR imaging. T1- and T2-weighted spin-echo MR images obtained before and after administration of IV gadopentetate dimeglumine were evaluated to determine the conspicuity of marrow and soft-tissue extent of tumor, including tumor involvement of major neurovascular bundles and adjacent joints. MR results were correlated with tumor margins found at surgery. In some instances, use of gadopentetate dimeglumine obscured differentiation of tumor from normal marrow or tumor infiltration into perineurovascular fat, and tumor extension through pseudocapsule could not be differentiated from peritumoral edema after contrast administration. Contrast enhancement did assist in differentiation of intraarticular tumor from effusion; however, synovial invasion could be identified on unenhanced T1-weighted images by loss of synovial fat and cortical disruption. These results indicate that gadopentetate dimeglumine does not assist in defining tumor margins of osteosarcoma.
authors.affiliation: Department of Radiological Sciences, University of California, School of Medicine, Los Angeles 90024-6952.
authors.forename: L L
authors.initials: LL
authors.lastname: Seeger
authors.forename: B E
authors.initials: BE
authors.lastname: Widoff
authors.forename: L W
authors.initials: LW
authors.lastname: Bassett
authors.forename: G
authors.initials: G
authors.lastname: Rosen
authors.forename: J J
authors.initials: JJ
authors.lastname: Eckardt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005266:Femoral Neoplasms / Q000175:diagnosis; D019786:Gadolinium DTPA; D006801:Humans; D006811:Humerus / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D012516:Osteosarcoma / Q000175:diagnosis* / Q000601:surgery; D004369:Pentetic Acid; D013977:Tibia / Q000473:pathology
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA