In vitro and in vivo comparison of arginine- and benzamidine-derived highly potent synthetic thrombin inhibitors.
Hauptmann
J
J
Institute of Pharmacology and Toxicology, Medical Academy Erfurt.
Kaiser
B
B
D000818:Animals; D000925:Anticoagulants / Q000138:chemical synthesis*; D001120:Arginine / Q000737:chemistry / Q000494:pharmacology*; D001550:Benzamidines / Q000737:chemistry / Q000494:pharmacology*; D001646:Bile / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D066298:In Vitro Techniques; D011517:Prothrombin Time; D011817:Rabbits; D051381:Rats; D013917:Thrombin / Q000037:antagonists & inhibitors*
D000925:Anticoagulants; D001550:Benzamidines; D001120:Arginine; D013917:Thrombin