Hepatic portal infusion of glucagon antibodies increases spontaneous meal size in rats.
Specific antibodies to pancreatic glucagon in a dose sufficient to neutralize 1.5 ng glucagon in vitro were intraportally infused during the first 2 min of spontaneous meals in ad libitum-fed male Sprague-Dawley rats. In separate tests, glucagon antibodies stimulated feeding during the first spontaneous meal of the dark phase (73% mean increase in meal size) and during spontaneous meals in the last quarter of the dark phase (58% increase). These results indicate that a glucagon-sensitive satiety mechanism has a physiological role in the control of nocturnal feeding in rats.
Le Sauter
J
J
Department of Psychology, Columbia University, New York, New York 10027.
Noh
U
U
Geary
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N
D000818:Animals; D000906:Antibodies / Q000502:physiology*; D003624:Darkness; D004435:Eating / Q000502:physiology*; D005934:Glucagon / Q000276:immunology*; D007262:Infusions, Intravenous; D008297:Male; D011169:Portal Vein; D051381:Rats; D011919:Rats, Inbred Strains
D000906:Antibodies; D005934:Glucagon