title: Is hsp70 the cellular thermometer?
abstract: Cells respond to an increase in temperature by inducing the synthesis of the heat shock proteins, which are a small set of evolutionarily conserved proteins. We review the evidence leading us to suggest that the free pool of one of these proteins, hsp70, serves as a cellular thermometer that regulates the expression of all heat shock proteins.
authors.affiliation: Department of Physiological Chemistry, University of Wisconsin-Madison 53706.
authors.forename: E A
authors.initials: EA
authors.lastname: Craig
authors.forename: C A
authors.initials: CA
authors.lastname: Gross
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000502:physiology*; D011387:Prokaryotic Cells / Q000502:physiology*; D013696:Temperature
chemical_list: D006360:Heat-Shock Proteins