[The influence of the Soviet antidepressants pyrazidol and inkazan on the effects of clonidine].
The influence of Soviet-made antidepressants pyrazidol and incazane on some clonidine-induced effects (hypolocomotion, reactions of synchronization and desynchronization in the EEG, aggression) were studied. Pyrazidol and incazane reduce the effects of low doses of clonidine--the hypolocomotor one and the synchronization reaction in the EEG and enhance the effects of a high dose of clonidine--aggression and the desynchronization reaction in the EEG. The reduction of the sedative effects of clonidine as well as the enhancement of its activating effects by antidepressants can reflect the activation of adrenergic transmission by them. The adrenopositive effect of pyrazidol and incazane is more pronounced that that of imipramine.
Kuksgaus
N E
NE
Golovina
S M
SM
Andreeva
N I
NI
D000374:Aggression / Q000187:drug effects; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002227:Carbazoles / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology*; D003344:Cortical Synchronization / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D011817:Rabbits
D000928:Antidepressive Agents; D002227:Carbazoles; D002243:Carbolines; C027473:metralindole; D003000:Clonidine; C009830:pirlindole
Vliianie otechestvennykh antidepressantov pirazidola i inkazana na nekotorye éffekty klonidina.