title: Genotoxic and mutagenic effects of the diagnostic use of thallium-201 in nuclear medicine.
abstract: In order to investigate possible mutagenic effects of in vivo exposure to low levels of ionizing radiation used in nuclear medicine, we have examined the hypoxanthine guanine phosphoribosyl transferase (hprt) mutant fraction (MF) and chromosome aberration (CA) frequency in 24 nuclear medicine patients before and after injection of thallium-201. The mean MF of the thallium-201-exposed cohort was 5.2 +/- 4.4 x 10(-6) before injection exposure. No significant difference in MF was observed 24 h later. In 11 patients who were studied on a third occasion, 30 days after thallium-201 exposure, there was again no significant difference in post-exposure as compared with the pre-exposure MF. The frequency of CA in peripheral blood lymphocytes was not significantly different, comparing pre- and 24 h to 1 month post-radionuclide exposure. Thus, thallium-201 exposure was not associated with significant elevations in MF or CA frequency in lymphocytes of exposed individuals.
authors.affiliation: Laboratory of Radiobiology, Harvard School of Public Health, Boston, MA 02215.
authors.forename: K T
authors.initials: KT
authors.lastname: Kelsey
authors.forename: K J
authors.initials: KJ
authors.lastname: Donohoe
authors.forename: B
authors.initials: B
authors.lastname: Baxter
authors.forename: A
authors.initials: A
authors.lastname: Memisoglu
authors.forename: J B
authors.initials: JB
authors.lastname: Little
authors.forename: M
authors.initials: M
authors.lastname: Caggana
authors.forename: H L
authors.initials: HL
authors.lastname: Liber
mesh_terms: D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D009153:Mutagens; D009154:Mutation; D013601:T-Lymphocytes / Q000528:radiation effects; D013794:Thallium Radioisotopes / Q000633:toxicity*; D013866:Thioguanine / Q000494:pharmacology
chemical_list: D009153:Mutagens; D013794:Thallium Radioisotopes; D007041:Hypoxanthine Phosphoribosyltransferase; D013866:Thioguanine