Titin, a huge, elastic sarcomeric protein with a probable role in morphogenesis.
Titin, the largest protein identified to date (over 1 micron long, almost 3 million daltons in mass) is the third most abundant component of the sarcomere. In the mature myofibril, titin molecules span from M line to Z line, forming a third filament system which provides sarcomeric alignment and elastic recoil. In the developing sarcomere, accumulating evidence from studies both in vivo and in vitro implicates titin as part of a morphogenetic scaffolding, upon which critical events in myofibrillogenesis are coordinated in a time- and space-dependent manner.
Fulton
A B
AB
Department of Biochemistry, University of Iowa, Iowa City 52242.
Isaacs
W B
WB
D000818:Animals; D064211:Connectin; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D009024:Morphogenesis; D009124:Muscle Proteins / Q000235:genetics / Q000502:physiology*; D009132:Muscles / Q000196:embryology*; D011494:Protein Kinases; D012518:Sarcomeres / Q000502:physiology*
D064211:Connectin; D008565:Membrane Proteins; D009124:Muscle Proteins; C577285:TTN protein, human; D011494:Protein Kinases