A rapid in vivo bioassay for the carcinogenicity of pesticides.
Eight pesticides were tested in a bioassay based on the induction of preneoplastic lesions in the liver. Rats were given diethylnitrosamine intraperitoneally at 200 mg/kg bw and two weeks later were treated with pesticides for six weeks and then killed; all rats had a partial hepatectomy at week 3. Hepatocarcinogenic potential was assessed by comparing the number and area of glutathione s-transferase (placental form) -positive foci in the liver with those of controls given diethylnitrosamine alone. Positive results were seen with Chinomethionat, Phosmet and Propiconazole; the results obtained with Captan and Prochloraz were borderline; Benomyl, Daminozide and Folpet gave negative results. Our findings provide enough experimental evidence to indicate that great care should be exercised in the use of these compounds.
Cabral
R
R
First Department of Pathology, Nagoya City University Medical School, Japan.
Hoshiya
T
T
Hakoi
K
K
Hasegawa
R
R
Fukushima
S
S
Ito
N
N
D000818:Animals; D001542:Benomyl / Q000633:toxicity; D002215:Captan / Q000633:toxicity; D015197:Carcinogenicity Tests / Q000379:methods*; D007093:Imidazoles / Q000633:toxicity; D008297:Male; D010575:Pesticides / Q000633:toxicity*; D010706:Phosmet / Q000633:toxicity; D010797:Phthalimides / Q000633:toxicity; D011810:Quinoxalines / Q000633:toxicity; D051381:Rats; D011916:Rats, Inbred F344; D013386:Succinates / Q000633:toxicity; D014230:Triazoles / Q000633:toxicity
D007093:Imidazoles; D010575:Pesticides; D010797:Phthalimides; D011810:Quinoxalines; D013386:Succinates; D014230:Triazoles; C045950:propiconazole; C005266:quinomethionate; C045362:prochloraz; D002215:Captan; C014499:daminozide; D001542:Benomyl; D010706:Phosmet; C005020:folpet