Effects of antihypertensive factor from erythrocyte of spontaneously hypertensive rats on the blood pressure and Ca2+ influx of arterial smooth muscle in rats.
The effects of a partially purified antihypertensive factor (AHF) from erythrocytes of spontaneously hypertensive rats (SHR) on the blood pressure (BP) and Ca2+ influx of vascular smooth muscle (VSM) in rats were studied. The results indicated that AHF could produce a marked prolonged depressor effect and significantly inhibit the Ca2+ influx dose-dependently on both SHR and renal hypertensive rat (RHR) either in acute or in chronic experiments, but not on normotensive rats. It suggested that the inhibition of Ca2+ influx might be one of the important mechanisms for AHF as an endogenous depressor substance.
Wen
Y Y
YY
Department of Physiology, Chinese Academy of Medical Sciences, Beijing.
Chen
M Q
MQ
Jia
H P
HP
Wu
G Y
GY
Zhou
L P
LP
Lu
T
T
Zhang
S F
SF
D000818:Animals; D001011:Aorta; D001685:Biological Factors / Q000494:pharmacology*; D001693:Biological Transport, Active; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism*; D004912:Erythrocytes / Q000737:chemistry; D008297:Male; D008638:Mesenteric Arteries; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY
D001685:Biological Factors; D002118:Calcium