title: CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain.
abstract: The cell division cycle gene CDC15 is essential for the late nuclear division in the yeast Saccharomyces cerevisiae. The amino acid sequence of the 974 amino acids/110 kDa CDC15 gene product, as deduced from the nucleotide sequence, includes an aminoterminal protein kinase domain which contains a primary sequence mosaic showing patterns specific for protein serine/threonine kinases besides those for protein tyrosine kinases. Many protein kinases non-essential for growth are known. CDC15 represents an essential protein kinase like CDC7 and CDC28. A carboxyterminal deletion of 32 amino acids renders the protein inactive.
authors.affiliation: Institut für Mikro- und Molekularbiologie der Universität Giessen, F.R.G.
authors.forename: B
authors.initials: B
authors.lastname: Schweitzer
authors.forename: P
authors.initials: P
authors.lastname: Philippsen
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002453:Cell Cycle / Q000235:genetics*; D004271:DNA, Fungal / Q000737:chemistry*; D008969:Molecular Sequence Data; D016296:Mutagenesis; D016366:Open Reading Frames; D010957:Plasmids; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics*; D015183:Restriction Mapping; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology / Q000235:genetics*; D016385:TATA Box
chemical_list: D004271:DNA, Fungal; D011494:Protein Kinases