[Validation of a new procedure for calculating tissue/blood distribution coefficient].
An economic procedure for calculating the tissue/blood distribution coefficient (Kp) for physiological models of pharmacokinetics is substantiated. It stems from evaluation of Kp vs. the drug concentration in tissue and blood specimens. The estimate of the time for collecting biosubstrates for assay of the drug content in them is inverse of the constant of the blood drug elimination rate: Kp = Ct/Cb, where Ct and Cb are the drug concentrations in tissues and blood at the time moment equal to 1/kel. In this procedure the estimates of Kp agree with the values calculated by the AUC procedure which is the most exact but much more labour-consuming.
Manuĭlov
K K
KK
Gefter
Iu V
IuV
D008433:Mathematics; D008722:Methods; D008954:Models, Biological; D010599:Pharmacokinetics; D014018:Tissue Distribution
Obosnovanie ispol'zovaniia novogo metoda dlia rascheta koéffitsienta raspredeleniia tkan'/krov'.