Difference in pressor responses to NG-monomethyl-L-arginine between conscious and anesthetized rats.
NG-Monomethyl-L-arginine (L-NMMA; 0.1-10 mg/kg, i.v.), a selective inhibitor of nitric oxide (NO) synthesis derived from L-arginine, elicited a greater increase in blood pressure in urethane/alpha-chloralose- and pentobarbital-anesthetized rats than in conscious Wistar rats. The pressor response to phenylephrine was almost equivalent in both conscious and anesthetized rats. These findings suggest that the experimental conditions (anesthetized or conscious) modify the spontaneously released NO's contribution to blood pressure regulation in vivo.
Aisaka
K
K
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research, Osaka, Japan.
Mitani
A
A
Kitajima
Y
Y
Ohno
T
T
Ishihara
T
T
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D002698:Chloralose / Q000494:pharmacology; D003243:Consciousness / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D010424:Pentobarbital / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014520:Urethane / Q000494:pharmacology; D019323:omega-N-Methylarginine
D000777:Anesthetics; D010656:Phenylephrine; D002698:Chloralose; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D014520:Urethane; D001120:Arginine; D010424:Pentobarbital