title: Biotransformation of halogenated compounds.
abstract: As a result of natural production and contamination of the environment by xenobiotic compounds, halogenated substances are widely distributed in the biosphere. Concern arises as a result of the toxic, carcinogenic, and potential teratogenic nature of these substances. The biotransformations of such halogenated substances are reviewed, with particular emphasis on the biocatalytic cleavage of the carbon-halogen bonds. The physiology, biochemistry, and genetics of the biological system involved in the dehalogenation reactions are discussed for three groups of organohalogens: (1) the haloacids, (2) the haloaromatics, and (3) the haloalkanes. Finally, the biotechnological applications of these microbial transformations are discussed. This includes prospects for their future application in biosynthetic processes for the synthesis of halogenated intermediates or novel compounds and also the use of such systems for the detoxification and degradation of environmental pollutants.
authors.affiliation: International Institute of Biotechnology, Canterbury, Kent, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Hardman
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001711:Biotransformation; D004787:Environmental Pollution / Q000517:prevention & control; D006846:Hydrocarbons, Halogenated / Q000737:chemistry / Q000493:pharmacokinetics*; D006867:Hydrolases / Q000235:genetics / Q000378:metabolism
chemical_list: D006846:Hydrocarbons, Halogenated; D006867:Hydrolases; C034507:2-haloacid dehalogenase; C046137:haloalkane dehalogenase