Studies on the anti-phospholipase A2 and anti-inflammatory activities of a synthetic nonapeptide from uteroglobin.
The nonapeptide H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH (antiflammin), corresponding to a high amino acid similarity region of uteroglobin was prepared by solution and solid phase synthesis. The peptide do not inhibit pancreatic phospholipase A2 in vitro and the carrageenin-induced oedema in vivo.
Marastoni
M
M
Department of Pharmaceutical Sciences, University of Ferrara, Italy.
Salvadori
S
S
Balboni
G
G
Scaranari
V
V
Santagada
V
V
Romualdi
P
P
Ferri
S
S
Tomatis
R
R
D000595:Amino Acid Sequence; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D051381:Rats; D011919:Rats, Inbred Strains; D014598:Uteroglobin / Q000737:chemistry / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010446:Peptide Fragments; C064645:antiflammin P1; D002351:Carrageenan; D014598:Uteroglobin; D010741:Phospholipases A; D054467:Phospholipases A2