Serotonin uptake in the blood platelets of Alzheimer's disease patients.
We determined serotonin (5-HT) uptake in the blood platelets of Alzheimer's disease (AD) patients and comparable age-matched normal controls. The maximum number of 5-HT uptake sites (Vmax) was significantly increased in mild and moderate AD patients, and a trend toward decreased V max was observed in severe AD patients as compared with normal controls. The Km of 5-HT uptake was negatively correlated with the Face-Hand Test (FHT) score of severely ill AD patients, whereas Vmax was correlated with the FHT score and the Mental Status Questionnaire score in the entire AD sample.
Arora
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RC
Department of Psychiatry Case Western Reserve University School of Medicine, Cleveland, OH.
Emery
O B
OB
Meltzer
H Y
HY
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000378:metabolism / Q000523:psychology; D000704:Analysis of Variance; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012016:Reference Values; D012701:Serotonin / Q000378:metabolism*; D011795:Surveys and Questionnaires
D012701:Serotonin