[Effects of ursodeoxycholic acid on mechanical and electric activities in isolated guinea pig heart muscles].
Using electromechanical transducer and conventional microelectrodes in isolated guinea pig heart muscles, the effects of ursodeoxycholic acid (UDCA) on the mechanical and electric activities were firstly observed. The results showed that, UDCA in dose of 0.05 mg/ml decreased contractile force by 36% (P less than 0.001) and shortened action potential duration (n = 3). It is inferred that UDCA may block inward calcium current. The results suggest that the action of UDCA is similar to that of bear bile and may be an effective composition of bear bile which acts on heart muscle. Our findings provide the experimental basis for the clinical application of UDCA.
Ye
D
D
Xuan-Wu Hospital, Capital Institute of Medicine, Beijing.
Han
D Y
DY
Wang
J R
JR
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects* / Q000502:physiology; D014580:Ursodeoxycholic Acid / Q000494:pharmacology*
D014580:Ursodeoxycholic Acid