title: Anterior segment ischemia in chronic herpes simplex keratouveitis.
abstract: Six patients with chronic herpes simplex keratouveitis developed a rapidly progressive ocular inflammation unresponsive to corticosteroid and antiviral therapy. Severe secondary glaucoma unresponsive to maximum medical therapy ensued and was treated by cyclocryotherapy in five patients. Ocular ischemia with secondary corneal and scleral calcification subsequently developed in all six patients. All had also received prolonged topical therapy with topical antiviral agents, corticosteroids, beta adrenergic blockers and epinephrine compounds. Three eyes eventually required enucleation for the relief of pain; one stabilized, and two others became phthisical. One of the phthisical eyes developed a secondary fungal endophthalmitis. Histopathologic examination of the three enucleated globes revealed extensive corneal, scleral and conjunctival calcification, secondary angle closure, iris and ciliary body necrosis, focal choroiditis, retinal necrosis and atrophy. The syndrome recognized in these patients appears to be a rare but devastating complication of herpes simplex keratouveitis, possibly exacerbated by the application of cyclocryotherapy and other factors.
authors.affiliation: Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, TN.
authors.forename: K J
authors.initials: KJ
authors.lastname: Johns
authors.forename: D M
authors.initials: DM
authors.lastname: O'Day
authors.forename: R A
authors.initials: RA
authors.lastname: Webb
authors.forename: A
authors.initials: A
authors.lastname: Glick
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000869:Anterior Eye Segment / Q000098:blood supply*; D000998:Antiviral Agents / Q000627:therapeutic use; D002114:Calcinosis / Q000209:etiology; D002908:Chronic Disease; D015353:Eye Enucleation; D005260:Female; D005901:Glaucoma / Q000209:etiology; D006801:Humans; D007511:Ischemia / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D007635:Keratitis, Dendritic / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014605:Uveitis / Q000150:complications* / Q000188:drug therapy
chemical_list: D000998:Antiviral Agents