Lack of ciprofloxacin ototoxicity after repeated ototopical application.
The possible side effects of ototopically applied ciprofloxacin on inner ear function were investigated. The hearing function of pigmented guinea pigs was evaluated by daily frequency-specific evoked response audiometry after repeated application of the drug to both ears. Ciprofloxacin appeared to have no statistically significant effect on the hearing thresholds of the experimental animals.
Claes
J
J
Department of Otorhinolaryngology, University of Antwerp, Belgium.
Govaerts
P J
PJ
Van de Heyning
P H
PH
Peeters
S
S
D000287:Administration, Topical; D000818:Animals; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D007758:Ear, Inner / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000139:chemically induced*; D008297:Male; D012684:Sensory Thresholds / Q000187:drug effects
D002939:Ciprofloxacin