[Clinicopathological estimation of intra-arterial infusion chemotherapy of locally advanced breast cancer].
The effect of intra-arterial infusion chemotherapy with adriamycin as a preoperating procedure was analyzed clinicopathologically in 30 cases with locally advanced breast cancer. A clinical response rate of 53.3% was obtained by the treatment and remarkable degenerative changes of tumor cells were noted histologically in the primary lesions. But there was no relationship between histological therapeutic effect and regression rate in tumors. A recurrence rate showed a higher correlation with histological therapeutic effect in comparison with clinical therapeutic effect. Especially, non-necrosis type that tumor cells were still alive mainly in the vessels showed significantly a higher recurrence rate in comparison with a central necrosis type or focal necrosis with fibrosis and hyalinization type. The local regional recurrence rate of patients receiving intra-arterial infusion chemotherapy was lower than that of patients, as the historical controls, receiving no therapy before operation. But prognostically, there was no significant difference in a survival rate between both groups. So, after operation, other alternative or multidisciplinary adjuvant chemo-endocrine therapy seems to be necessary for improving the survival rate.
Doihara
H
H
Dept. of Surgery, Shikoku Cancer Center Hospital, Ehime, Japan.
Takashima
S
S
Kawashima
K
K
Kino
K
K
Takeda
S
S
Funakoshi
M
M
Yokoyama
N
N
Tanada
M
M
Soga
H
H
Kurita
A
A
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000401:mortality; D011300:Preoperative Care; D011379:Prognosis; D015996:Survival Rate
D004317:Doxorubicin