[Inhibin, steroid hormone, and gonadotropin concentration in blood from fertile and infertile males and its relationship with testicular function].
The role of inhibin in the testicular function and its relation with other hormone regulation spermatogenesis have not been elucidated in the human, therefore we studied by RIA the serum concentrations of this testicular secretion product, as well as those of LH, FSH, T and E2 and their possible correlation with some parameters evaluated by spermatobioscopy (cell number, motility, morphology and immature germinal cells) in fertile, oligozoospermic and azoospermic men. We did not find significant differences in inhibin concentration between fertile and oligozoospermic males; however in the azoospermic group the mean inhibin concentration was significantly higher (722.9 +/- 137.9 U/l in the fertile men; 658.5 +/- 147.1 and 963.1 +/- 300.9 U/l in the oligozoospermic and azoospermic groups respectively), in spite of data dispersion in the 3 study groups. Among the fertile males we found a negative significant correlation between the inhibin and the LH and FSH concentrations (p less than 0.05), while in the oligozoospermic patients this negative correlation was observed with T concentration. In the fertile males inhibin also showed correlation with the sperm percentage with normal morphology and with the immature germinal cells in semen; in the oligozoospermic group this glycoprotein showed correlation with the sperm count and the germinal cells concentration. We also found correlation between testosterone and/or LH concentrations and sperm count in both groups. These results indicate modifications in the hormonal concentrations regulating the testicular function and in their relationship, in men with testicular damage, which can render a change in the mechanisms controlling this function.(ABSTRACT TRUNCATED AT 250 WORDS)
Chavarría
M E
ME
Laboratorio de Bioquímica de la Reproducción, Subjefatura de Investigación, IMSS.
Díaz-Sánchez
V
V
McLachlan
R I
RI
Domville
E
E
Tapia
R
R
D004958:Estradiol / Q000097:blood*; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D007265:Inhibins / Q000097:blood*; D008297:Male; D009845:Oligospermia / Q000097:blood* / Q000503:physiopathology; D013081:Sperm Motility; D013094:Spermatozoa; D013739:Testosterone / Q000097:blood*
D006065:Gonadotropins, Pituitary; D013739:Testosterone; D004958:Estradiol; D007265:Inhibins
Concentración de inhibina, hormonas esteroides y gonadotrofinas en el suero sanguíneo de varones fértiles e infértiles y su relación con la función testicular.