[Rhino-cerebral mucormycosis and hematological neoplasia].
Mucormycosis is a rare infection that occurs in immunocompromised patients. The rhinocerebral form presents in diabetics as a severe necrotizing sinusitis and is not frequent in patients with haematologic malignancies. Diagnosis requires direct examination and culture of biopsy specimens. Two patients with rhinocerebral mucormycosis and haematologic neoplasms (Non-Hodgkin's lymphoma and acute myeloblastic leukaemia) are described. Both patients had severe drug-induced neutropenia when the infection appeared. One patient died in spite of aggressive treatment with surgery and amphotericin.
Pintado
V
V
Servicio de Medicina Interna, Hospital La Paz, Madrid.
Valencia
M E
ME
López-Dupla
J M
JM
Lavilla
P
P
Feliú
J
J
Gil
A
A
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy / Q000209:etiology*; D010000:Osteitis / Q000209:etiology*; D012852:Sinusitis / Q000209:etiology*; D012886:Skull
D000666:Amphotericin B
Mucormicosis rinocerebral y neoplasia hematológica.