Negative effect on early post-implantation pregnancy and progesterone levels in mice infected with the intestinal trematode Echinostoma caproni.
Infection in mice (BALB/cABom) with the intestinal trematode Echinostoma caproni had a negative influence on pregnancy. The effect of the infection set in immediately following implantation (day 5 of pregnancy) resulting in fewer foetuses being present in infected mice on day 9 than in the controls. Ovulation, fertilization of eggs, and implantation itself were obviously not impaired. The infected mice had significantly lower serum progesterone levels on day 5 of pregnancy than the non-infected controls. It is speculated that the progesterone levels in the infected female mice were too low to secure early post-implantation gestation.
Bindseil
E
E
Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
Hau
J
J
D000818:Animals; D004451:Echinostomiasis / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005298:Fertility; D005306:Fertilization; D008098:Litter Size; D051379:Mice; D010060:Ovulation; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000503:physiopathology*; D011256:Pregnancy Outcome; D011374:Progesterone / Q000097:blood*
D011374:Progesterone