Bone remodelling after growth factor and cyclosporine A therapy for aplastic anemia.
We describe a patient with viral induced aplastic anemia who developed severe bone pain after treatment with multiple courses of antithymocyte globulin, cyclosporine A, recombinant human granulocyte macrophage colony stimulating factor and deferoxamine. Radiographs and bone biopsy revealed extensive new trabecular bone formation in long bone diaphyses and adjacent periosteal reaction. The effects of hematopoietic growth factors, cyclosporine A and deferoxamine on bone metabolism are reviewed.
Derfus
B A
BA
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.
Csuka
M E
ME
Carrera
G F
GF
Hanson
G A
GA
Smith
R E
RE
D000293:Adolescent; D000741:Anemia, Aplastic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D003524:Cyclosporins / Q000627:therapeutic use*; D003676:Deferoxamine / Q000627:therapeutic use; D005260:Female; D005360:Fibula / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D006133:Growth Substances / Q000627:therapeutic use*; D006801:Humans; D011859:Radiography; D011994:Recombinant Proteins / Q000627:therapeutic use; D013977:Tibia / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology
D000961:Antilymphocyte Serum; D003524:Cyclosporins; D006133:Growth Substances; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D003676:Deferoxamine