[Changes in oxygen extraction rate after craniocerebral injury].
Changes of oxygen metabolism were observed in 8 experimental dogs and in 9 patients with head injury. Each dog harbored a bag in the epidural space, and was injected normal saline. The ICP was raised to 13.3 kPa and to 20.0 kPa respectively. Arterial oxygenation declined and mixed venous oxygenation went up when the ICP was raised to the given level and maintained for 30 minutes. The oxygen extraction rate decreased from 25.00 +/- 5.40% to 21.50 +/- 4.60% (P less than 0.01) at the ICP level of 20 kPa. Tissue hypoxia was observed in all patients. Although PaO was higher than inspiring air when patients inhaled 50% oxygen. Tissue hypoxia was not improved. The results suggest that the patients head injury is complicated by not only hypoxemia but decrease of oxygen extraction in tissue and organs. We consider that the alteration is responsible for multiple organs failure injury.
Liu
S L
SL
Changzheng Hospital, Second Military Medical College, Shanghai.
D000328:Adult; D000818:Animals; D001784:Blood Gas Analysis; D001930:Brain Injuries / Q000378:metabolism*; D002543:Cerebral Hemorrhage / Q000378:metabolism; D004285:Dogs; D005260:Female; D006406:Hematoma / Q000378:metabolism; D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption
D010100:Oxygen