title: Mutagenic activity of photoreaction products formed from chlorinated ethenes and nitrogen dioxide.
abstract: The mutagenicity in Salmonella, strain TA 100, of photoreaction products from chlorinated alkenes and nitrogen dioxide, was studied after a mean reaction time of 40 min with UV-irradiation and an exposure time of 20 hr. Only vinyl chloride (monochloroethene) gave rise to significantly mutagenic photoreaction products. Of the other chloroethenes, 1,1-dichloroethene and tetrachloroethene, but not 1,2-dichloro- or trichloroethene, formed slightly mutagenic products. Bacteriotoxic effects occurred at low doses, especially with tri- and tetrachloroethene.
authors.affiliation: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Victorin
authors.forename: M
authors.initials: M
authors.lastname: Ståhlberg
mesh_terms: D004000:Dichloroethylenes / Q000378:metabolism; D016296:Mutagenesis / Q000187:drug effects*; D009153:Mutagens / Q000378:metabolism / Q000494:pharmacology*; D009585:Nitrogen Dioxide / Q000378:metabolism*; D012475:Salmonella / Q000235:genetics / Q000378:metabolism; D013750:Tetrachloroethylene / Q000378:metabolism; D013997:Time Factors; D014466:Ultraviolet Rays; D014752:Vinyl Chloride / Q000378:metabolism*
chemical_list: D004000:Dichloroethylenes; D009153:Mutagens; D009585:Nitrogen Dioxide; D013750:Tetrachloroethylene; D014752:Vinyl Chloride