Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part III--Combination experiments.
The combined effects of amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were investigated on the murine leukemic cell line P388 D1. As the best result a summation of the antiproliferative effects was observed. Combinations with established cytostatic agents like platinum complexes or other antitumor compounds also yielded partly additive effects. In experiments performed with asparaginase L-aspartic acid-beta-hydroxamate gave synergistic growth inhibition of P388 D1 cells in vitro, which was reflected by additive effects against murine leukemia P388 in vivo.
Laske
R
R
Institut für Pharmazie, Universität Regensburg, FRG.
Schönenberger
H
H
Holler
E
E
D000596:Amino Acids / Q000037:antagonists & inhibitors*; D000604:Amino Acyl-tRNA Synthetases / Q000037:antagonists & inhibitors*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D004347:Drug Interactions; D007941:Leukemia P388 / Q000503:physiopathology; D051379:Mice
D000596:Amino Acids; D000970:Antineoplastic Agents; D000604:Amino Acyl-tRNA Synthetases