Drug depots in lymph nodes: which carrier is most appropriate?
Different drug carriers for endolymphatic use (suspensions, emulsions, solutions, liposomes) were investigated in animal experiments to find the preparation which is best tolerated by lymph tissue, and which allows low release of highly concentrated drugs from nodal depots. The large unilamellar liposomes produced with detergent dialysis technique were found to be most appropriate for this purpose since they fulfill all the above criteria.
Hirnle
P
P
Department of Gynaecology, University of Tübingen.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004337:Drug Carriers; D006801:Humans; D007272:Injections, Intralymphatic; D008198:Lymph Nodes / Q000378:metabolism*; D008207:Lymphatic Metastasis
D000970:Antineoplastic Agents; D004337:Drug Carriers