[Influence of topical administration of diclofenac on the reduction of intraocular pressure induced by timolol in healthy subjects].
The presence or absence of an interaction between topical diclofenac (nonsteroidal antiinflammatory agent) and topical timolol (beta-blocker) was studied in 37 eyes. We instilled one drop of diclofenac several times into the patient's right eye and one drop of timolol into the same eye. We measured intraocular pressure in both eyes twice and compared the results in both eyes with the baseline intraocular pressure and with the pressure after administration of diclofenac alone and timolol alone. The joint use of both drugs did not modify the decrease in the ocular pressure induced by timolol. We can therefore use timolol and diclofenac together when a combination of antiinflammatory and beta-blocker agents is required.
Castillo Laguarta
J
J
Hôpital Clinique Universitaire de Saragosse, Service d'Ophtalmologie, Zaragoza.
Loras Alegre
E
E
Minana Beamonte
I
I
Ascaso Puyuelo
J
J
Garcia Garcia
J
J
Palomar Gomez
A
A
Cristobal Bescos
J A
JA
D000287:Administration, Topical; D003864:Depression, Chemical; D004008:Diclofenac / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004341:Drug Evaluation; D004347:Drug Interactions; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D013997:Time Factors; D013999:Timolol / Q000008:administration & dosage / Q000494:pharmacology*
D004008:Diclofenac; D013999:Timolol
Influence de l'administration topique de diclofénac sur la réduction de la pression intraoculaire produite par le timolol chez des sujets sains.