Synthesis and anti human immune virus activity of some new fluorine containing substituted -3-thioxo-1,2,4-triazin-5-ones.
Some new fluorine containing substituted 3-thioxo-1,2,4-triazin-5-ones (2-17) have been synthesized and evaluated for in vitro anti human immune virus (HIV) activity. Most of the new compounds displayed a lethal activity, while compounds 2, 6, 7, 10, 11 and 14 displayed a significant antiviral activity. The structures are supported by elemental analysis, IR, UV and 1H-NMR spectral data.
Abdel-Rahman
R M
RM
Chemistry Department, Faculty of Education, Ain-Shams University, Cairo, Roxy, Egypt.
D000998:Antiviral Agents / Q000138:chemical synthesis*; D002460:Cell Line; D005461:Fluorine / Q000494:pharmacology; D005562:Formazans / Q000378:metabolism; D006678:HIV / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D005562:Formazans; D013438:Sulfhydryl Compounds; D014227:Triazines; D005461:Fluorine