Simultaneous determination of imipramine and amitryptiline by derivative spectrophotometry.
Three methods are proposed for the simultaneous determination of imipramine and amitryptiline by derivative spectrophotometry, one of them using both first- and second-derivative spectra, and the others using the first- and second-derivative spectra, respectively, obtained from a "diode array" spectrophotometer. The methods allow the determination of 0.62-10.14 micrograms ml-1 of imipramine, and 0.63-10.04 micrograms ml-1 of amitryptiline, and have been applied to their determination in blood serum.
García Fraga
J M
JM
Department of Analytical Chemistry, Bromatology and Toxicology, University of La Laguna, Tenerife, Spain.
Jiménez Abizanda
A I
AI
Jiménez Moreno
F
F
Arias León
J J
JJ
D000639:Amitriptyline / Q000032:analysis* / Q000097:blood; D006801:Humans; D007099:Imipramine / Q000032:analysis* / Q000097:blood; D007202:Indicators and Reagents; D013056:Spectrophotometry, Ultraviolet
D007202:Indicators and Reagents; D000639:Amitriptyline; D007099:Imipramine