title: Dedifferentiated chondrosarcoma arising from osteochondromatosis. A case report.
abstract: Multiple hereditary osteochondromata has a higher incidence (5%-25%) of malignant change into chondrosarcoma than solitary osteochondroma (1%-2%); but only less than 10% of all chondrosarcomas may undergo dedifferentiated change into fibrosarcoma or malignant fibrous histiocytoma. We have a case presented here with osteochondromatosis who was found to have dedifferentiated chondrosarcoma arising from pelvic osteochondroma. Radical extra-compartmental resection was done and followed by chemotherapy and radiotherapy. Recurrence was found 3 months later. Early recognition of malignant change and adequate surgical resection with adjuvant therapy may prevent local recurrence and increase the survival rate.
authors.affiliation: Department of Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
authors.forename: Y K
authors.initials: YK
authors.lastname: Du
authors.forename: H N
authors.initials: HN
authors.lastname: Shih
authors.forename: J M
authors.initials: JM
authors.lastname: Wang
authors.forename: C H
authors.initials: CH
authors.lastname: Shih
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D002813:Chondrosarcoma / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D005097:Exostoses, Multiple Hereditary / Q000150:complications*; D006801:Humans; D008297:Male