title: Effect of excess dietary fat during the third trimester of pregnancy on maternal, placental, and fetal metabolism in the pig.
abstract: The effect of excessive intake of dietary fat during late gestation on maternal, placental, and fetal metabolism was studied. Twelve pregnant gilts were fed ad libitum diets containing 4 (control) or 55% (added fat) calories as fat, beginning on day 70 of gestation. On day 110, glucose and palmitate oxidation, and incorporation into fatty acids by maternal adipose tissue, maternal and fetal placenta, and fetal liver and adipose tissue were determined. Caloric efficiency and adipose tissue glucose utilization were reduced in the added fat gilts, while placenta metabolism at high media palmitate concentrations was increased. Fetal development and metabolism were for the most part unaffected by maternal diet; thus, the fetus appears to be protected from dietary excess through adaptations of both maternal and placental metabolism.
authors.affiliation: Department of Foods and Nutrition, University of Georgia, Athens.
authors.forename: D B
authors.initials: DB
authors.lastname: Hausman
authors.forename: R W
authors.initials: RW
authors.lastname: Seerley
authors.forename: R J
authors.initials: RJ
authors.lastname: Martin
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D004041:Dietary Fats / Q000494:pharmacology*; D005314:Embryonic and Fetal Development; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D008098:Litter Size; D010168:Palmitates / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D013552:Swine
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D005227:Fatty Acids; D010168:Palmitates