Synthesis and antihypertensive activity of some 2-aminobenzimidazole and indole derivatives.
The synthesis of some 2-aminobenzimidazole and indole amide derivatives containing a 2,6-dichloroaniline moiety is described. The preparation of a theophylline derivative is also reported. All the compounds tested showed no appreciable antihypertensive activity on spontaneously hypertensive rats.
Da Settimo
A
A
Istituto di Chimica Farmaceutica dell'Università di Pisa, Italy.
Marini
A M
AM
Primofiore
G
G
Subissi
A
A
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology; D006973:Hypertension / Q000503:physiopathology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D001562:Benzimidazoles; D007211:Indoles; C027391:2-aminobenzimidazole; D003000:Clonidine