title: Topical photoprotection for hereditary polymorphic light eruption of American Indians.
abstract: We evaluated the photoprotective efficacy of a broad-spectrum sunscreen containing a UVA screen (butyl methoxydibenzoylmethane) and a UVB screen (octyl dimethyl p-aminobenzoic acid) in patients with hereditary polymorphic light eruption. At least 18 of the 30 patients who enrolled in the study were sensitive to sunlight through window glass, an indication of UVA sensitivity. Of the 21 patients who completed the clinical trial, the physician's evaluation was that 18 (86%) obtained good to excellent results. Self-evaluation by the patients revealed that 16 (76%) noted more photoprotection than from previous treatments.
authors.affiliation: Department of Medicine (Dermatology), University of Nebraska Medical Center, Omaha.
authors.forename: R M
authors.initials: RM
authors.lastname: Fusaro
authors.forename: J A
authors.initials: JA
authors.lastname: Johnson
mesh_terms: D010129:4-Aminobenzoic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D001565:Benzoates / Q000008:administration & dosage / Q000627:therapeutic use; D047188:Chalcones; D002985:Clinical Protocols; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007198:Indians, North American; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D010787:Photosensitivity Disorders / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D011427:Propiophenones; D013473:Sunscreening Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D062366:para-Aminobenzoates
chemical_list: D001565:Benzoates; D047188:Chalcones; D004338:Drug Combinations; D011427:Propiophenones; D013473:Sunscreening Agents; D062366:para-Aminobenzoates; C059933:avobenzone, padimate O drug combination; C049935:avobenzone; D010129:4-Aminobenzoic Acid