title: Epidemiology of encephalitis in children: a 20-year survey.
abstract: Four hundred five children from the Helsinki area who were 1 month to 16 years old were treated for acute encephalitis at the Children's Hospital, University of Helsinki, from January 1968 through December 1987. Encephalitis occurred most commonly in children 1 to 1.9 years of age, among whom the incidence was 16.7 per 100,000 child-years. The incidence remained quite high until the age of 10 years, and then gradually declined to 1.0 per 100,000 child-years at the age of 15 years. Since 1983, when mumps, measles, and rubella vaccination eradicated the encephalitides associated with these microbes, the major associated agents have been varicella-zoster, Mycoplasma pneumoniae, and respiratory and enteroviruses. In infants younger than 1 year of age, the major agents were enteroviruses, herpes simplex virus, and the group of "others," whereas in older children, respiratory viruses and Mycoplasma pneumoniae, as well as varicella-zoster virus, dominated. In children aged 1 to 11 months, the causal agent could not be identified in one-half of all cases, whereas in children who were at least 10 years old, the etiology remained unknown in only one-fourth of cases. Male dominance was most evident in the 4- to 9-year age group. The difference in etiology between males and females was significant (p = 0.02); mumps and varicella were more common in boys, and adenovirus and Mycoplasma pneumoniae were more common in girls. The overall male-to-female ratio was 1.4:1. Characteristic seasonal variation occurred in encephalitides associated with mumps, measles, and entero- and respiratory viruses.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Virology, University of Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Koskiniemi
authors.forename: J
authors.initials: J
authors.lastname: Rautonen
authors.forename: E
authors.initials: E
authors.lastname: Lehtokoski-Lehtiniemi
authors.forename: A
authors.initials: A
authors.lastname: Vaheri
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004660:Encephalitis / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D005387:Finland / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D012621:Seasons