Sialoproteins of bone and dentin.
Osteopontin (OPN), bone sialoprotein (BSP) and bone acidic glycoprotein-75 (BAG-75), are sialoproteins isolated from bone extracts that resemble each other in size and composition. OPN and BSP contain an RGD sequence (not proven but possible for BAG-75), suggesting that their biological functions involve interaction with cell membrane integrins. Dentin has small amounts of OPN and BSP but also contains a major sialic acid-rich protein, DSP that has an overall composition similar to the bone sialoproteins. It is possible that DSP plays a similar biological role in dentin as OPN, BSP, and BAG-75 play in bone. Future experimentation should shed further light onto the potential relationships of the four sialoproteins.
Butler
W T
WT
Department of Biological Chemistry, University of Texas Health Science Center, Houston 77225.
D000818:Animals; D001842:Bone and Bones / Q000737:chemistry*; D002448:Cell Adhesion; D003804:Dentin / Q000737:chemistry*; D006801:Humans; D058574:Integrin-Binding Sialoprotein; D053495:Osteopontin; D010750:Phosphoproteins / Q000032:analysis; D012795:Sialoglycoproteins / Q000032:analysis*
C546871:IBSP protein, human; D058574:Integrin-Binding Sialoprotein; D010750:Phosphoproteins; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin