Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy.
A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (PUVA) treated patients. Levels of sIL-2R showed a strong correlation with the psoriasis area and severity index (PASI). CsA and PUVA significantly reduced the PASI and sIL-2R levels to a similar degree after 4 weeks of treatment. Although the majority of CsA-treated patients who were biopsied showed reductions in lesional CD25+ cells, these did not reach statistical significance; in five patients biopsied who had PUVA treatment, no consistent effect on the numbers of CD25+ cells was observed. A significant correlation was found between CD25+ cells in lesional biopsies and the PASI score.
Duncan
J I
JI
Department of Pathology, University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Scotland.
Horrocks
C
C
Ormerod
A D
AD
Powles
A V
AV
Whiting
P H
PH
Fry
L
L
Thomson
A W
AW
D000328:Adult; D003524:Cyclosporins / Q000627:therapeutic use*; D006801:Humans; D011701:PUVA Therapy; D011565:Psoriasis / Q000188:drug therapy / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000097:blood*; D013601:T-Lymphocytes / Q000276:immunology*
D003524:Cyclosporins; D015375:Receptors, Interleukin-2