title: Cholecystokinin cholescintigraphy: detection of abnormal gallbladder motor function in patients with chronic acalculous gallbladder disease.
abstract: CCK cholescintigrams were performed in 374 patients with recurrent postprandial right upper quadrant pain, biliary colic, and a normal gallbladder sonogram and/or cholecystogram. The results of these examinations were correlated with the patients' final medical/surgical diagnoses. Twenty-seven patients recruited as control volunteers without objective clinical evidence of biliary disease also underwent CCK cholescintigraphy to determine if the degree of gallbladder contraction post-CCK differs in symptomatic versus asymptomatic subjects. Decreased gallbladder motor function was identified (maximal gallbladder ejection fraction response to CCK less than 35%) in 94% of patients with histopathologically confirmed chronic acalculous cholecystitis or the cystic duct syndrome and in 88% of patients clinically believed to have chronic acalculous biliary disease. Decreased gallbladder motor function does not distinguish symptomatic from asymptomatic gallbladder disease.
authors.affiliation: Nuclear Medicine Department, William Beaumont Hospital, Royal Oak, MI 48073-6769.
authors.forename: D
authors.initials: D
authors.lastname: Fink-Bennett
authors.forename: P
authors.initials: P
authors.lastname: DeRidder
authors.forename: W Z
authors.initials: WZ
authors.lastname: Kolozsi
authors.forename: R
authors.initials: R
authors.lastname: Gordon
authors.forename: R
authors.initials: R
authors.lastname: Jaros
mesh_terms: D002766:Cholecystokinin; D002908:Chronic Disease; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005705:Gallbladder Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007098:Imino Acids; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D019785:Technetium Tc 99m Disofenin
chemical_list: D007098:Imino Acids; D015609:Organotechnetium Compounds; D002766:Cholecystokinin; D019785:Technetium Tc 99m Disofenin