[Increased polyamine levels of normal-appearing mucosa and cancers in DMH induced cancer-bearing colon in rats].
Polyamine levels (putrescine, spermidine, spermine) in normal-appearing colonic mucosa of DMH administrated rats were measured in order to assess their importance as markers of precancerous changes. Mean putrescine, spermidine and spermine levels of normal-appearing mucosa were more than three times mean putrescine, more than twice mean spermidine and more than 1.5 times mean spermine levels of normal colonic mucosa. Mean polyamine levels of colon cancers were higher than those of normal-appearing mucosa but only spermidine level was significantly different between them. The mucosal polyamine levels may be a good biochemical marker to detect precancerous changes. There was no correlation between the polyamine levels and the growth rate of the colon cancers.
Tsunoda
A
A
Department of Surgery, School of Medicine, Showa University.
Shibusawa
M
M
Yoshizawa
H
H
Yasuda
N
N
Tsuno
K
K
Koike
T
T
D000818:Animals; D003106:Colon / Q000737:chemistry; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000737:chemistry*; D004127:Dimethylhydrazines; D004195:Disease Models, Animal; D007413:Intestinal Mucosa / Q000737:chemistry*; D008297:Male; D011073:Polyamines / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D004127:Dimethylhydrazines; D011073:Polyamines