title: Synthesis and antiinflammatory activity of indole carboxylic acids and esters.
abstract: 1-Phenylalkylindole-3-carboxylic acids 1-4, indole-1-acetic acids/esters 5-10 and the hydrazones 11-15 were prepared and submitted to the rat paw edema test using carrageenin. In the first two groups of compounds, the 2-chloro indoles were more active than the corresponding indole derivatives. In the third group the activity seemed to be determined largely by the substituent at the 1-position.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, University of Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Andreani
authors.forename: M
authors.initials: M
authors.lastname: Rambaldi
authors.forename: A
authors.initials: A
authors.lastname: Locatelli
authors.forename: M
authors.initials: M
authors.lastname: Conti
authors.forename: S
authors.initials: S
authors.lastname: Malandrino
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002264:Carboxylic Acids; D004952:Esters; D007211:Indoles