[Value of isometric and dynamic exercise tests with standard drug doses for selecting long-term antihypertensive treatment with vasodilators, adrenergic beta blockaders and diuretics].
The paper presents the results of the study into the efficacy of single routine doses of essential antihypertensive agents (nifedipine, propranolol, and hydrochlorothiazide) versus its course treatment at rest and during isometric and dynamic exercise tests. The efficacy was assessed by using the Dixon criterion. The routine drug dose tests performed at rest and during isometric and dynamic exercise were shown to have a varying informative value in the prediction of long-term treatment with the above drugs. The isometric and dynamic exercise tests are of the greatest significance in the evaluation of the antihypertensive routine dose of nifedipine, whereas the dynamic exercise test alone is of value for propranolol and the rest exercise test, the both exercise tests for hydrochlorothiazide. Thus, the results of the corresponding routine drug dose tests are of varying predictive informative value, which is essential both for choosing an effective drug and for making an objective assessment of the outcomes of the course therapy.
Korinteli
M O
MO
Metelitsa
V I
VI
Ostrovskaia
T P
TP
Vygodin
V A
VA
D000328:Adult; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage*; D013997:Time Factors
D006852:Hydrochlorothiazide; D011433:Propranolol; D009543:Nifedipine
Znachenie izometricheskogo i dinamicheskogo nagruzochnykh testov so standartnymi dozami dlia vybora dlitel'nogo antigipertenzivnogo lecheniia vazodilatatorami, beta-adrenoblokatorami i diuretikami.