Mosaic 46,XY/92,XXYY,del(5)(q13 q34) in an adult lymphoblastic leukemia.
Usually the chromosome anomalies encountered in ALL are modal number abnormalities (hyperdiploidy or hypodiploidy) and structural anomalies such as t(8;14), t(11;14), t(9;22), t(1;19) and del(6p). The 5q- syndrome is mainly associated with myelodysplastic syndromes and with ANLL (M1, M2, M3). We report the case of a patient presenting with a mosaic karyotype 46,XY/92,XXYY,del(5)(q13 q34) in the following proportion 1/3 normal mitoses and 2/3 tetraploid mitoses.
Valtat
C
C
Laboratoire de Cytogenetique, Hopital de Hautepierre, Strasbourg, France.
Uettwiller
F
F
Flori
E
E
Valtat
B
B
Ruch
J V
JV
Oberling
F
F
D000368:Aged; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5 / Q000502:physiology; D006801:Humans; D007621:Karyotyping; D008297:Male; D011003:Ploidies; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012729:Sex Chromosome Aberrations / Q000235:genetics; D014960:X Chromosome / Q000502:physiology; D014998:Y Chromosome / Q000502:physiology