[The effect of low concentrations of adaptogen solutions on the functional activity of murine bone marrow cells in vitro].
Influence of water solutions of chemically pure adaptogens--a synthetic analog of Rhodiola rosea extract phenol combination (SAR) and Dibazol on the functional activity of mice hemopoietic cells in vitro was studied. A clear periodical character of drugs effects manifestation with a tendency to the stimulating activity domination was revealed. A reliable stimulation of clonogenic activity was in correlation with 4 x 10(-11) and 4 x 10(-15) adaptogens molecules in SAR and Dibazol solutions per 1 blood marrow cell. This phenomenon is suggested to be connected with the solvent (water) molecules changes and the formation of structures, keeping the information of adaptogenes with possible translation of the latter during the process of consistent dissolution of the solvent.
Udintsev
S N
SN
Shakhov
V P
VP
Borovskoĭ
I G
IG
Ibragimova
S G
SG
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects* / Q000254:growth & development; D001854:Bone Marrow Cells; D066298:In Vitro Techniques; D051379:Mice; D008815:Mice, Inbred Strains; D009125:Muscle Relaxants, Central; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*
D001562:Benzimidazoles; D009125:Muscle Relaxants, Central; D010636:Phenols; D010936:Plant Extracts; C004453:bendazole
Vliianie malykh kontsentratsiĭ rastvorov adaptogenov na funktsional'nuiu kletok kostnogo mozga mysheĭ in vitro.