An assessment of the control of matrix turnover by a quantitative ultrastructural analysis of fibroblasts of the periodontal ligament in rats.
A quantitative structural analysis of the synthetic and degradative organelles of fibroblasts of rat incisor and molar periodontal ligaments was conducted. The results showed that in these tissues which are reported to have significantly different rates of turnover of their functional matrix collagen the rate of synthetic activity was the same. However, there were differences in the pattern of degradation with the molar ligament having between 5 and 6 times more phagocytosed collagen than the incisor. It is suggested that post-synthesis processing may control collagen turnover rather than modulation of rates of synthesis.
Shore
R C
RC
Department of Oral Biology, University of Leeds, U.K.
Kirkham
J
J
Robinson
C
C
Moxham
B J
BJ
Berkovitz
B K
BK
D000818:Animals; D002452:Cell Count; D003094:Collagen / Q000032:analysis / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000378:metabolism; D005347:Fibroblasts / Q000737:chemistry / Q000648:ultrastructure*; D007180:Incisor; D008247:Lysosomes / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008963:Molar; D009697:Nucleolus Organizer Region / Q000737:chemistry / Q000378:metabolism; D015388:Organelles / Q000737:chemistry / Q000378:metabolism*; D010513:Periodontal Ligament / Q000166:cytology* / Q000648:ultrastructure; D011506:Proteins / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012270:Ribosomes / Q000737:chemistry / Q000378:metabolism; D014617:Vacuoles / Q000737:chemistry / Q000378:metabolism
D011506:Proteins; D003094:Collagen