[The new Soviet narcotic analgesic phenaridine as a component of general anesthesia during cancer surgery].
The results of studies on 65 cancer patients operated on under modified neuroleptanalgesia using fenaridine give evidence of a more potent and prolonged analgetic effect of a new Soviet narcotic analgesic fenaridine as compared to fentanyl. Fenaridine ensures stable neuroautonomous protection of the body during cancer surgery and is indicated in prolonged traumatic surgical interventions with cardiopulmonary bypass. Along with the above advantages fenaridine possesses all the complex of side effects typical of opiates associated with the depression of respiratory centres, psychoemotional sphere, activation of parasympathetic centres which may complicate the period following the patient's withdrawal from anesthesia and necessitate prolonged controlled lung ventilation in the early postoperative period. Thus, during 3-5-hour-long surgery it is advisable to administer the basic amount of the overall drug dose during the first 1-1.5 h of anesthesia and surgery, which promotes the awakening of most patients 10-15 min after surgery. Another drawback of fenaridine is the onset of marked rigor and signs of microcirculation disturbances upon discontinuation of the drug effect.
Osipova
N A
NA
Petrova
V V
VV
Novikov
G A
GA
Dolgopolova
T V
TV
Zhukova
O I
OI
Mel'nikova
Z L
ZL
Smolina
T A
TA
D015761:4-Aminopyridine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000009:adverse effects; D005260:Female; D005283:Fentanyl; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000601:surgery*; D009458:Neuroleptanalgesia
D000700:Analgesics; D015761:4-Aminopyridine; C054783:phenaridine; D005283:Fentanyl
Novyĭ otechestvennyĭ narkoticheskiĭ analgetik fenaridina kak komponent obshcheĭ anestezii v onkokhirurgii.