title: Fluctuation of anti-A and anti-B histo-blood-group antibodies in a patient after liver transplantation.
abstract: The concentrations of anti-A and anti-B IgM and IgG antibodies have been studied in the serum of a patient with blood group AB who received a type A donor liver. A newly developed ABO-ELISA was used for this purpose and the values were compared to hemagglutination titers. During the postoperative study period over 8 weeks, the anti-A and anti-B levels showed a higher fluctuation than was measured in preoperative samples. Thus, in this AB-type patient, anti-A IgM varied 10-fold, anti-A IgG 20-fold and anti-B IgG 16-fold. Peak values corresponded to rejection episodes. Immunoactivation in the patient was further documented by the presence of abnormally high levels of soluble interleukin-2 receptors (sIL-2R) in serum samples. The study shows that monitoring of anti-A/B antibodies may represent a further criterion to follow-up transplanted patients during the critical postoperative graft acceptance period.
authors.affiliation: Central Laboratory of Hematology, University Hospital, Bern, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Zimmerli
authors.forename: J
authors.initials: J
authors.lastname: Lerut
authors.forename: P
authors.initials: P
authors.lastname: Müller
authors.forename: A
authors.initials: A
authors.lastname: Zimmermann
authors.forename: U
authors.initials: U
authors.lastname: Nydegger
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology*; D006501:Hepatic Encephalopathy / Q000276:immunology / Q000601:surgery*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007518:Isoantibodies / Q000032:analysis*; D016031:Liver Transplantation / Q000276:immunology*; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology*
chemical_list: D000017:ABO Blood-Group System; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007518:Isoantibodies