title: New vistas on 5-HT receptors and migraine.
abstract: 1. A number of serotonergic agents have been shown to be effective in the treatment of migraine. At the present time, migraine drug interactions have been analyzed most extensively at 5-hydroxytryptamine1D (5-HT1D), 5-HT2 and 5-HT3 receptor subtypes. 2. This review will summarize the current status of 5-HT receptor subtypes as they relate to anti-migraine agents. 3. The available data suggest that drug interactions with specific 5-HT receptor subtypes may be the basis for their efficacy in both the acute and prophylactic treatment of migraine.
authors.affiliation: Department of Neurology, Stanford University Medical Center, CA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Peroutka
mesh_terms: D000818:Animals; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy / Q000503:physiopathology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*
chemical_list: D011985:Receptors, Serotonin