[Effect of chronic antiplatelet treatment on platelet activating factor-induced platelet activity in stroke].
The effect of chronic antiplatelet treatment on PAF--induced platelet aggregation, ATP--release, and cytoplasmic ionized calcium was studied in 20 acute ischemic stroke patients. Chronic antiplatelet treatment failed to suppress these PAF--induced platelet responses. We speculate that selective PAF antagonists may be useful in suppressing PAF--induced platelet activation, and thereby possibly improve the treatment of stroke.
Han
E
E
Dept. of Neurology Affiliated Hospital, Shandong Medical University.
Joseph
R
R
Grunfeld
S
S
Welch
K M
KM
D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D002561:Cerebrovascular Disorders / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects*
D010972:Platelet Activating Factor; D000255:Adenosine Triphosphate; D001241:Aspirin; D002118:Calcium; D007052:Ibuprofen