title: Lesions of the medial septal nucleus produce a long-lasting inhibition of T lymphocyte proliferation.
abstract: The influence of the central cholinergic system on the immune system was studied in Wistar rats by lesioning the medial septal nucleus. This lesion inhibited T cell proliferation of splenocytes and thymocytes induced by the mitogens concanavalin A (Con A), phytohemagglutinin (PHA) and pokeweed mitogen (PWM) up to 25 days and did not affect proliferation at 40 days after lesioning. In contrast, the response to the B cell mitogen lipopolysaccharide from E. coli (LPS) was not affected at any time. These findings suggest a regulatory role of the cholinergic medial septal nucleus on T lymphocyte proliferation.
authors.affiliation: Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET-Argentina), Universidad de Buenos Aires.
authors.forename: M
authors.initials: M
authors.lastname: Labeur
authors.forename: V E
authors.initials: VE
authors.lastname: Nahmod
authors.forename: S
authors.initials: S
authors.lastname: Finkielman
authors.forename: E
authors.initials: E
authors.lastname: Arzt
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology / Q000502:physiology*; D002478:Cells, Cultured; D005260:Female; D008213:Lymphocyte Activation; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D013997:Time Factors