The effect of trisomy 18 on transverse cerebellar diameter.
The transverse cerebellar diameter was measured in 19 fetuses with trisomy 18. Eleven of the cerebellar measurements (57.9%) were greater than 2 SD below the mean for the patient's gestational age. If fetal biometry rather than last menstrual period were used to determine gestational age, four of the 19 (21.0%) cerebellar measurements were greater than 2 SD below the mean. Both intrauterine growth retardation and intrinsic central nervous system abnormalities associated with trisomy 18 appeared to affect cerebellar size.
Hill
L M
LM
Department of Ultrasound, Magee-Womens Hospital, University of Pittsburgh, PA 15213.
Marchese
S
S
Peterson
C
C
Fries
J
J
D002531:Cerebellum / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D002887:Chromosomes, Human, Pair 18; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012189:Retrospective Studies; D014314:Trisomy; D014463:Ultrasonography