title: Hemodynamic alterations and regional myocardial blood flow during supraceliac aortic occlusion in dogs with a critical coronary stenosis.
abstract: The hemodynamic consequences and myocardial blood flow alterations associated with cross-clamping of the thoracic aorta were studied during pentobarbital (control), halothane (1 MAC), and isoflurane (1 MAC) anesthesia in dogs with a critical stenosis of the left circumflex coronary artery. Aortic clamping at the level of the diaphragm resulted in significant and equivalent increases in mean aortic pressure and left atrial pressure during the control clamp, halothane clamp, and isoflurane clamp periods. Likewise, aortic clamping resulted in a significant and equivalent decrease in cardiac output during control-clamp, halothane clamp, and isoflurane clamp. Myocardial contractility as assessed by dP/dt was depressed during halothane and isoflurane anesthesia when compared with control, but no further change in contractility was associated with aortic clamping. No significant alterations in regional or transmural myocardial blood flow were found with halothane or isoflurane anesthesia, or with aortic clamping during halothane or isoflurane anesthesia. It is concluded that there are significant hemodynamic consequences associated with aortic clamping, that neither halothane nor isoflurane anesthesia alters these consequences when compared with pentobarbital anesthesia alone, and that the deterioration in myocardial function observed during aortic clamping with halothane and isoflurane anesthesia cannot be attributed to any maldistribution of myocardial blood flow.
authors.affiliation: Department of Anesthesiology and Surgery, University of Michigan, Ann Arbor.
authors.forename: J A
authors.initials: JA
authors.lastname: Wahr
authors.forename: K P
authors.initials: KP
authors.lastname: Gallagher
authors.forename: A R
authors.initials: AR
authors.lastname: Tait
authors.forename: C B
authors.initials: CB
authors.lastname: Hantler
authors.forename: P R
authors.initials: PR
authors.lastname: Knight
mesh_terms: D000769:Anesthesia, Inhalation; D000818:Animals; D001013:Aorta, Thoracic / Q000503:physiopathology* / Q000601:surgery; D016279:Atrial Function, Left / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology*; D003250:Constriction; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology*; D003327:Coronary Disease / Q000503:physiopathology* / Q000601:surgery; D004285:Dogs; D005260:Female; D006221:Halothane / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007530:Isoflurane / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D011651:Pulmonary Artery; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology
chemical_list: D007530:Isoflurane; D006221:Halothane