Inhibition of meal-stimulated gastric acid secretion by gastrin immunoneutralization in rats.
Gastrin 17-I was infused into conscious rats equipped with jugular and portal vein catheters and with a pyloric gastric drainage tube to achieve serum concentrations slightly higher than those found during intragastrically instilled peptone solutions. I.v. injected rabbit gastrin antiserum abolished gastrin 17-I-stimulated gastric acid secretion in these animals. Gastrin immunoneutralization reduced peptone-stimulated gastric acid secretion by approximately 37% during the entire 30-min period of stimulation. Peptone-stimulated gastric acid secretion was only significantly (P less than 0.05) inhibited in the third 10-min period, but not in the first or second 10-min periods of stimulation. This study demonstrates that the late but not the initial period of peptone-stimulated gastric acid secretion is regulated by circulating gastrin in rats.
Van de Brug
F J
FJ
Department of Gastroenterology and Hepatology, University Hospital Leiden, The Netherlands.
Jansen
J B
JB
Kuijpers
R J
RJ
Lamers
C B
CB
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D007106:Immune Sera; D008297:Male; D010461:Peptones / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains
D005755:Gastrins; D007106:Immune Sera; D010461:Peptones; C013550:gastrin 17