[Adaptation of the body to the effects of stress increases the resistance of cardiac nuclei to damaging effects of single-chain exogenous DNA].
The effect of adaptation to stress exposure on the resistance of nuclear DNA to damaging effect of one-chain exogenous DNA was investigated by flow cytometric fluorescence method. It was shown that after the administration of one-chain DNA in concentration of 50 micrograms/ml into the nuclei suspension almost half of nuclear DNA was damaged in control. In adaptation this phenomenon was 5.5 times less pronounced. When the one-chain DNA concentration was increased, this protective effect of adaptation remained. The possible mechanism of the DNA-protective effect of adaptation is under consideration.
Meerson
F Z
FZ
Malyshev
I Iu
IIu
Varfolomeeva
E Iu
EIu
Varfolomeev
O B
OB
Noskin
A N
AN
D000222:Adaptation, Physiological; D000818:Animals; D004247:DNA / Q000032:analysis* / Q000187:drug effects; D004277:DNA, Single-Stranded / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*
D004277:DNA, Single-Stranded; D004247:DNA
Adaptatsiia organizma k stressornym vozdeĭstviiam povyshaet ustoĭchivost' iader serdechnykh kletok k povrezhdaiushchemu deĭstviiu odnonitevoĭ ékzogennoĭ DNK.