Biomonitoring of human exposure to alkylating agents by measurement of adducts to haemoglobin or DNA.
Recent analytical developments in the determination of adducts of DNA and protein with alkylating carcinogens are described which have considerably extended the number of carcinogens that can be examined. While sensitivity of detection equal to or better than one modified DNA base per 10(8) normal bases is now achievable for many specific alkylating carcinogens, further developments in the analytical methods are still needed for the identification and quantification of adducts derived from unknown and/or mixed exposures to carcinogens.
Farmer
P B
PB
MRC Toxicology Unit, Carshalton, Surrey, UK.
Bailey
E
E
Green
J A
JA
Leung
C S
CS
Manson
M M
MM
D000477:Alkylating Agents / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D010761:Phosphorus Radioisotopes; D011506:Proteins / Q000378:metabolism
D000477:Alkylating Agents; D006454:Hemoglobins; D010761:Phosphorus Radioisotopes; D011506:Proteins; D004247:DNA