[The immunomorphological characteristics of a focal staphylococcal infection against a background of long-term exposure to low doses of simazine].
State of immunologic and nonspecific resistance of the organism, ultra- and histostructure of the thymus, histopathology of the wall of experimental staph abscess reproduced in animals given low doses of the herbicide simazine for a long time have been studied. It is established that simazine induced the immunodeficiency state underlain by pathologic changes in the thymus. Against this background experimental abscesses developed more rapidly, alterative and exudative processes in their wall proceeding more intensively and proliferative ones--attenuating. This provides prolongation of the abscesses healing phase for an indefinite time and chronization of the process.
Paliĭ
G K
GK
Barshteĭn
Iu A
IuA
Persidskiĭ
Iu V
IuV
Ben'iaminov
V O
VO
Pushkar'
M S
MS
Iakubovskiĭ
M M
MM
D000038:Abscess / Q000276:immunology* / Q000473:pathology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005490:Focal Infection / Q000276:immunology* / Q000473:pathology; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012839:Simazine / Q000008:administration & dosage / Q000633:toxicity*; D013203:Staphylococcal Infections / Q000276:immunology* / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D013997:Time Factors
D012839:Simazine
Immunomorfologicheskaia kharakteristika ochagovoĭ stafilokokkovoĭ infektsii na fone dlitel'nogo vozdeĭstviia malykh doz simazina.