title: [Oligo- and polynucleotide probes. A molecular hybridization method].
abstract: In this review the main principles and possibilities of a hybridization analyses as a highly specific methods for diagnostics of infections and genetic diseases are discussed. Special attention is paid to the chemical approaches to the preparation of non-radioactive probes based on synthetic oligonucleotides and polynucleotides containing biotin, Eu3+ and enzyme labels. Some versions of the hybridization analysis technique are discussed.
authors.forename: A G
authors.initials: AG
authors.lastname: Badashkeeva
authors.forename: D G
authors.initials: DG
authors.lastname: Knoppe
mesh_terms: D005819:Genetic Markers; D006801:Humans; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes / Q000737:chemistry
chemical_list: D005819:Genetic Markers; D015345:Oligonucleotide Probes
vernacular_title: Oligo- i polinukleotidnye zondy. Metod molekuliarnoĭ gibridizatsii.