Clinical correlation with serum-soluble interleukin-2 receptor levels in Guillain-Barré syndrome.
In patients with Guillain-Barré syndrome (GBS) soluble interleukin-2 receptor (sIL-2R) levels were elevated compared with those of patients with other neurologic diseases (OND), and of healthy controls. Smaller increases in sIL-2R levels occurred in OND patients compared to healthy subjects. Monitoring of GBS patients clearly demonstrated that decreases in sIL-2R levels correlated with clinical recovery. Thus, T-cell activation may be relevant in the pathogenesis of GBS.
Bansil
S
S
Department of Neurosciences, University of Medicine & Dentistry of New Jersey, New Jersey Medical School, Newark 07103.
Mithen
F A
FA
Cook
S D
SD
Sheffet
A
A
Rohowsky-Kochan
C
C
D002493:Central Nervous System Diseases / Q000097:blood / Q000503:physiopathology; D005192:Family Health; D006801:Humans; D009422:Nervous System Diseases / Q000097:blood / Q000503:physiopathology; D009994:Osmolar Concentration; D011129:Polyradiculoneuropathy / Q000097:blood* / Q000235:genetics / Q000503:physiopathology; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012016:Reference Values; D012995:Solubility
D015375:Receptors, Interleukin-2