Modulation of the intestinal flora of mice by treatment with aztreonam and tigemonam.
Oral and parenteral administration of aztreonam and oral administration of tigemonam to conventional mice caused a decrease in the number of aerobic gram-negative rods in the feces. Oral treatment with high doses of aztreonam (greater than or equal to 25 mg/kg/day) and tigemonam (100 mg/kg/day) adversely influenced colonization resistance, whereas oral treatment with lower doses of the monobactams or parenteral treatment with aztreonam did not.
van Ogtrop
M L
ML
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
Guiot
H F
HF
Mattie
H
H
van Strijen
E
E
Sekh
B R
BR
van Furth
R
R
D000284:Administration, Oral; D000818:Animals; D001398:Aztreonam / Q000008:administration & dosage / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004352:Drug Resistance, Microbial; D005243:Feces / Q000382:microbiology; D005260:Female; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects; D007279:Injections, Subcutaneous; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*; D051379:Mice; D008997:Monobactams / Q000008:administration & dosage / Q000494:pharmacology*
D008997:Monobactams; C052020:tigemonam; D001398:Aztreonam