title: Do pyrimidine dimer yields correlate with erythema induction in human skin irradiated in situ with ultraviolet light (275-365 nm)?
abstract: Ultraviolet radiation produces erythema in human skin, and damages the DNA of living cells in skin. Previous work showed that broad-band UV-B (290-320 nm) radiation produced higher levels of cyclobutyl pyrimidine dimers in DNA of individuals with high UV-B sensitivity (low minimal erythema dose) than in subjects of low UV-B sensitivity [Freeman et al. (1986) J. Invest. Dermatol., 86, 34-36]. We examined the relationship between erythema induction and dimer yields in DNA of human skin irradiated in situ with narrow band radiation spanning the wavelength range 275-365 nm. We find that, in general, higher dimer yields are produced per incident photon in volunteers with higher susceptibility to erythema induced by radiation of the same wavelength.
authors.affiliation: Biology Department, Brookhaven National Laboratory, Upton, NY 11973.
authors.forename: H
authors.initials: H
authors.lastname: Hacham
authors.forename: S E
authors.initials: SE
authors.lastname: Freeman
authors.forename: R W
authors.initials: RW
authors.lastname: Gange
authors.forename: D J
authors.initials: DJ
authors.lastname: Maytum
authors.forename: J C
authors.initials: JC
authors.lastname: Sutherland
authors.forename: B M
authors.initials: BM
authors.lastname: Sutherland
mesh_terms: D000328:Adult; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000209:etiology; D006801:Humans; D011740:Pyrimidine Dimers / Q000528:radiation effects; D012867:Skin / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D011740:Pyrimidine Dimers