Closed loop blood pressure control for cerebral perfusion studies.
A method is presented which maintains mean arterial blood pressure at predetermined values during cerebrovascular occlusion studies in a rat model. The system consists of a pressure measurement apparatus, a pump capable of infusing and withdrawing fluids, and a personal computer to control the infusion and withdrawal rate. An evaluation of the system is presented, and potential advantages and difficulties are discussed.
Chambers
I R
IR
Regional Medical Physics Department, Newcastle General Hospital, UK.
Strachan
R D
RD
Kane
P J
PJ
Clark
A
A
Mendelow
A D
AD
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000503:physiopathology; D001810:Blood Volume / Q000502:physiology; D002539:Cerebral Arterial Diseases / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D007023:Hypotension, Controlled / Q000379:methods*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains