High-level resistance to cefotaxime and ceftazidime in Klebsiella pneumoniae isolates from Cleveland, Ohio.
Two isolates of Klebsiella pneumoniae possessing both TEM-1 and SHV-2 beta-lactamases were isolated from patients at the Cleveland Clinic in 1988. The beta-lactamases were discriminated and identified by using substrate hydrolysis data and an isoelectric focusing procedure in which the gel was overlaid with beta-lactamase inhibitors.
Thomson
K S
KS
Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178.
Sanders
C C
CC
Washington
J A
JA
D002439:Cefotaxime / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D007525:Isoelectric Focusing; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology; D009820:Ohio; D010957:Plasmids; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000378:metabolism
D065093:beta-Lactamase Inhibitors; D002442:Ceftazidime; D001618:beta-Lactamases; D002439:Cefotaxime