Inner ear deafness in Wegener's granulomatosis.
Autoimmune deafness represents a heterogeneous group of disorders in which there is though to be inner ear and/or middle ear damage mediated by various immunological abnormalities. We describe a patient with Wegener's granulomatosis in whom there was evidence of significant inner ear damage caused by vasculitis, which was completely reversed by cyclophosphamide and prednisolone. We propose that Wegener's granulomatosis is a cause of autoimmune deafness.
Luqmani
R
R
Department of Rheumatology, Selly Oak Hospital, Birmingham, UK.
Jubb
R
R
Emery
P
P
Reid
A
A
Adu
D
D
D000328:Adult; D001327:Autoimmune Diseases / Q000209:etiology* / Q000473:pathology; D002465:Cell Movement / Q000502:physiology; D003520:Cyclophosphamide / Q000627:therapeutic use; D003638:Deafness / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D007758:Ear, Inner / Q000473:pathology / Q000503:physiopathology; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology / Q000502:physiology; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D014657:Vasculitis / Q000150:complications / Q000188:drug therapy / Q000473:pathology
D003520:Cyclophosphamide; D011239:Prednisolone