Elevated medial-frontal cerebral blood flow in obsessive-compulsive patients: a SPECT study.
Regional cerebral blood flow was measured with single photon emission computed tomography in 10 obsessive-compulsive patients and eight comparison subjects. The patients had a significantly higher ratio of medial-frontal to whole cortex blood flow; this was unrelated to symptom severity but was correlated negatively with anxiety. No differences in orbital-frontal blood flow were found.
Machlin
S R
SR
Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD.
Harris
G J
GJ
Pearlson
G D
GD
Hoehn-Saric
R
R
Jeffery
P
P
Camargo
E E
EE
D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000503:physiopathology; D002540:Cerebral Cortex / Q000098:blood supply / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime