title: Western blot analysis of immunoglobulin G antibodies to pneumococcal protein antigens in healthy adults.
abstract: Using the Western Blot technique, sera from apparently healthy individuals were shown to contain antibodies against pneumococcal protein antigens of different molecular weights. A remarkable correlation was found to exist between the number of protein bands stained and the level of antibodies to type-specific carbohydrate antigens and C-polysaccharide. The findings suggest that the presence of antibodies against protein antigens reflects past infection with pneumococci.
authors.affiliation: Department of Clinical Microbiology, Copenhagen University, Herley General Hospital, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Renneberg
authors.forename: M
authors.initials: M
authors.lastname: Svinhufvud
authors.forename: K
authors.initials: K
authors.lastname: Prellner
authors.forename: P
authors.initials: P
authors.lastname: Christensen
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D000942:Antigens, Bacterial / Q000097:blood*; D015153:Blotting, Western / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007074:Immunoglobulin G