title: [Comparative evaluation of 2 schedules of administration of anti- neoplastic drugs by the CMF protocol in disseminated breast cancer].
abstract: Combined chemotherapy with cyclophosphamide, methotrexate, fluorouracil (CMF) in two regimens of administration was comparatively assessed in a randomized and prospective trial. Group I patients (n = 34) received methotrexate and fluorouracil once a week and cyclophosphamide every other day for 15 days. In group II (n = 32) all the drugs were given simultaneously once weekly for 15 days. A complete and partial response occurred significantly more frequently in patients of group I (36%) versus group II (7%). The intergroup difference in toxicity appeared insignificant.
authors.forename: D B
authors.initials: DB
authors.lastname: Korman
authors.forename: V A
authors.initials: VA
authors.lastname: Snimshchikov
authors.forename: L B
authors.initials: LB
authors.lastname: Dobroskok
authors.forename: I A
authors.initials: IA
authors.lastname: Maslova
authors.forename: S G
authors.initials: SG
authors.lastname: Mikaélian
authors.forename: E V
authors.initials: EV
authors.lastname: Pines
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000556:secondary; D008727:Methotrexate / Q000008:administration & dosage; D011446:Prospective Studies; D012074:Remission Induction
chemical_list: D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Sravnitel'naia otsenka dvukh rezhimov vvedeniia protivoopukholevykh preparatov po skheme CMF pri disseminirovannom rake molochnoĭ zhelezy.