Biocompatible polyphosphazenes by radiation-induced graft copolymerization and heparinization.
Investigations were carried out on the radiation-induced graft copolymerization by direct irradiation of dimethylaminoethyl methacrylate on to poly(bis(trifluoroethoxy)phosphazene) and on to poly (bis(phenoxy)phosphazene). Kinetics of grafting were followed with the polyphosphazenes immersed in monomer - methanol mixtures of various composition. The grafted film samples were quaternized with methyl iodide and, to the produced ammonium group, heparin was ionically bonded with high yield. On the grafted and heparinized-grafted film samples an evaluation of hydrophilicity, mechanical properties, biocompatibility and anticoagulating properties was carried out.
Lora
S
S
Istituto di Fotochimica e Radiazioni d' Alta Energia (Sez, Legnaro), Italy.
Carenza
M
M
Palma
G
G
Pezzin
G
G
Caliceti
P
P
Battaglia
P
P
Lora
A
A
D000818:Animals; D001672:Biocompatible Materials; D001777:Blood Coagulation; D006493:Heparin; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009943:Organophosphorus Compounds / Q000528:radiation effects*; D011108:Polymers / Q000528:radiation effects*; D019736:Prostheses and Implants; D051381:Rats; D012016:Reference Values
D001672:Biocompatible Materials; D009943:Organophosphorus Compounds; D011108:Polymers; D006493:Heparin