Angiotensin II increases MAO activity in rat central nervous system.
The effects of angiotensin II (ANG II) and bilateral nephrectomy on monoamine oxidase (MAO) activity were studied in rat hypothalamus and medulla oblongata. ANG II increased MAO activity in both central nervous system (CNS) regions. The fall of circulating ANG II caused by 48 h bilateral nephrectomy decreased the activity of the enzyme in the mentioned areas. The results showed that ANG II stimulates catecholamine metabolism in the CNS.
Fernández
B E
BE
Departamento de Ciencias, Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Domínguez
A E
AE
D000804:Angiotensin II / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002648:Child; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects* / Q000201:enzymology; D008526:Medulla Oblongata / Q000187:drug effects* / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D009392:Nephrectomy; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012084:Renin-Angiotensin System / Q000502:physiology; D013268:Stimulation, Chemical
D009419:Nerve Tissue Proteins; D000804:Angiotensin II; D008995:Monoamine Oxidase; D009638:Norepinephrine