Sibs with a disorder resembling Blount disease (tibia vara).
Radiographic investigation of 3 Turkish sibs presenting with bowed legs disclosed physiological tibial bowing in the 7-month-old girl. Stage I Blount disease in the 26 month-old boy and Stage II Blount disease in the 45 month-old girl. The reported cases provide evidence for autosomal recessive inheritance. This observation points to genetic heterogenity, i.e. the existence of 2 genetically different, but radiologically indistinguishable disorders.
Schmidt
H
H
Department of Pediatrics, University Mainz, FRG.
Mundlos
S
S
Spranger
J W
JW
D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010007:Osteochondritis / Q000000981:diagnostic imaging / Q000235:genetics*; D010020:Osteonecrosis / Q000000981:diagnostic imaging / Q000235:genetics*; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging