[An evaluation of combination antibiotic therapy in infections with hematological disorders. Hyogo Cooperative Study Group of Infectious Diseases Complicating Hematological Disorders].
A clinical study was undertaken to determine the effects of combination antibiotic therapy in 104 patients with infections associated with hematological disorders. All patients were treated with sulbactam/cefoperazone (SBT/CPZ) plus an aminoglycoside as an empiric therapy for fever. The overall efficacy rate of the therapy was 63.5%. Efficacy rates were 61.2% and 71.9% when initial neutrophil counts were less than 500/mm3 and over 500/mm3, respectively. No significant difference was found between the cases in which initially used antibiotics were continued (efficacy rate 62.5%) and those in which antibiotics were switched during the course of therapy (65.6%). Antibiotic therapy with SBT/CPZ plus an aminoglycoside provides adequate antibiotic coverage against infections associated with hematological disorders. This combination was highly effective even in the neutropenic periods of febrile patients.
Takemoto
Y
Y
2nd Department of Internal Medicine, Hyogo College of Medicine.
Kanamaru
A
A
Kakishita
E
E
Nakayama
S
S
Hara
H
H
Yamaguchi
N
N
Tsutsui
T
T
Mitsutani
S
S
Tago
H
H
Sonoda
T
T
D000328:Adult; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D002438:Cefoperazone / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D008297:Male; D013407:Sulbactam / Q000008:administration & dosage / Q000627:therapeutic use*
D002438:Cefoperazone; D013407:Sulbactam