Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen.
Two propart peptides of aspartic proteinases, the propart peptide of chicken pepsin and human cathepsin D, respectively, were investigated from the point of view of their inhibitory activity for a set of aspartic proteinases. These peptides display a very broad inhibitory spectrum. The strongest inhibition was observed for pepsin A-like proteinases where propart peptides can be used as titrants of active enzymes.
Fusek
M
M
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague.
Mares
M
M
Vágner
J
J
Voburka
Z
Z
Baudys
M
M
D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D002402:Cathepsin D / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002645:Chickens; D004792:Enzyme Precursors / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010434:Pepsin A / Q000037:antagonists & inhibitors; D010435:Pepsinogens / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000494:pharmacology*
D004792:Enzyme Precursors; D010435:Pepsinogens; D011480:Protease Inhibitors; D016282:Aspartic Acid Endopeptidases; C058345:procathepsin D; D010434:Pepsin A; D002402:Cathepsin D