Intrastriatal dialysis evidence for a direct inhibitory effect of benztropine on dopamine re-uptake.
A direct inhibitory effect of benztropine on dopamine (DA) reuptake in the striatum was established by in vivo microdialysis of anesthetized rats. Benztropine was infused by means of a microdialysis probe positioned stereotaxically in the striatum. Extracellular DA collected from dialysate was measured by high-performance liquid chromatography using an electrochemical detector. Benztropine was found to cause a dose-dependent inhibition of re-uptake of DA in the nerve terminal area of the dopaminergic system.
Itoh
K
K
Department of Neuropsychopharmacology (Tsumura), Gunma University, School of Medicine, Japan.
Ikarashi
Y
Y
Way
E L
EL
Maruyama
Y
Y
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001590:Benztropine / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D003956:Dialysis / Q000379:methods; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006719:Homovanillic Acid / Q000378:metabolism; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D015102:3,4-Dihydroxyphenylacetic Acid; D001590:Benztropine; D004298:Dopamine; D006719:Homovanillic Acid