[The role of the phenomenon of the redistribution of aminoglycosides in their monitoring and dosage calculation in patients in the terminal stage of kidney failure undergoing systematic hemodialysis treatment].
The kinetics of aminoglycosides (amikacin, netilmycin, gentamicin, tobramycin) were investigated in patients with end-stage renal disease who were on systemic hemodialysis. Their decrease in the blood revealed in pre-dialysis and dialysis periods was exponential. After dialysis termination there was a gradual aminoglycoside increase as compared to the end-dialysis period, which was of linear character and depended on the degree of these agents' dialysis clearance. The cause of the phenomenon is likely to be higher aminoglycoside blood elimination rate than their entering the blood from tissues. A method is proposed to calculate an additional dose of aminoglycosides, taking into account their higher concentrations in the postdialysis period, under permanent monitoring of their blood levels.
Siniukhin
V N
VN
Darenkov
A F
AF
Stetsiuk
E A
EA
Nikolaeva
N P
NP
Iarmolinskiĭ
I S
IS
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood*; D003131:Combined Modality Therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008657:Metabolic Clearance Rate; D008991:Monitoring, Physiologic; D012044:Regression Analysis; D006435:Renal Dialysis / Q000379:methods; D013997:Time Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents
Rol' fenomena pereraspredeleniia aminoglikozidov v ikh monitoringe i raschete doz u bol'nykh s terminal'noĭ stadieĭ pochechnoĭ nedostatochnosti, nakhodiashchikhsia na lechenii sistematicheskim gemodializom.