title: Taurolin as an oral rinse. II. Effects on in vitro and in vivo plaque regrowth.
abstract: A Taurolin solution has been shown previously to possess antibacterial activity, not only by a bactericidal effect but also by reducing bacterial surface adherence. Such mechanisms may contribute to reduction in dental plaque in the mouth, however this remains to be determined. The present study assessed whether a Taurolin rinse could firstly effect bacterial surface growth and, secondly, whether the same rinse could reduce plaque regrowth over a 4-day period. The findings showed that the Taurolin reduced in vitro bacterial surface growth and in vivo plaque regrowth compared to saline, but was not as effective as a chlorhexidine rinse. The findings suggest Taurolin would probably have a moderate effect on plaque and gingivitis in longer-term use.
authors.affiliation: Dental School, University of Wales College of Medicine, Cardiff.
authors.forename: S
authors.initials: S
authors.lastname: Reynolds
authors.forename: J
authors.initials: J
authors.lastname: Moran
authors.forename: W G
authors.initials: WG
authors.lastname: Wade
authors.forename: M
authors.initials: M
authors.lastname: Addy
authors.forename: R
authors.initials: R
authors.lastname: Newcombe
mesh_terms: D000704:Analysis of Variance; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D003773:Dental Plaque / Q000517:prevention & control*; D005260:Female; D005891:Gingivitis / Q000517:prevention & control; D006801:Humans; D008297:Male; D009067:Mouthwashes; D013295:Streptococcus mutans / Q000187:drug effects*; D013654:Taurine / Q000031:analogs & derivatives*; D013829:Thiadiazines / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D009067:Mouthwashes; D013829:Thiadiazines; D013654:Taurine; C012566:taurolidine; C010882:chlorhexidine gluconate; D002710:Chlorhexidine