Bone protein and peptide assays in the diagnosis and management of skeletal disease.
The measurement in blood of bone proteins is an important adjunct to imaging procedures for clinical assessment of the skeleton. The discovery of new bone proteins and their structural characterization has led to immunochemical procedures of improved sensitivity and specificity for their quantification. An appreciation of the advantages and disadvantages of these evolving methodologies will assist in their clinical application.
Deftos
L J
LJ
Department of Medicine, University of California, San Diego.
D000135:Acid Phosphatase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood*; D001847:Bone Diseases / Q000175:diagnosis* / Q000628:therapy; D001842:Bone and Bones / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000097:blood*; D003094:Collagen / Q000097:blood*; D016326:Extracellular Matrix Proteins; D006801:Humans; D015675:Osteocalcin / Q000097:blood*; D000097568:Matrix Gla Protein
D000135:Acid Phosphatase; D000469:Alkaline Phosphatase; D002135:Calcium-Binding Proteins; D003094:Collagen; D016326:Extracellular Matrix Proteins; D015675:Osteocalcin; D000097568:Matrix Gla Protein