title: Is GIFT (gamete intrafallopian transfer) the best treatment for unexplained infertility?
abstract: OBJECTIVE
  To compare the cumulative pregnancy rates after gamete intrafallopian transfer (GIFT) with the cumulative spontaneous pregnancy rates in couples with unexplained infertility.
  
  
  METHODS
  A contemporaneous study in a single group of patients.
  
  
  METHODS
  Northern Regional Fertility Centre.
  
  
  METHODS
  76 couples with unexplained infertility of more than 3 years duration.
  
  
  METHODS
  Successful pregnancies were recorded during at least 3 months before GIFT and up to 21 months after a maximum of three cycles of GIFT treatment.
  
  
  METHODS
  Pregnancy resulting in a live birth.
  
  
  RESULTS
  Average monthly fecundability without treatment was 0.021 and after GIFT was 0.14 (P less than 0.001). This was reflected as a cumulative pregnancy rate of 52% after three cycles of GIFT and 30% after 24 months without treatment.
  
  
  CONCLUSIONS
  The chance of having a baby after one cycle of GIFT is significantly greater than the chance in a spontaneous cycle. However, considering the cumulative pregnancy rates, we suggest that if GIFT is to be a realistic treatment option, it should be offered for more than one cycle.
authors.affiliation: Northern Regional Fertility Centre, Department of Obstetrics and Gynaecology, Royal Victoria Infirmary, Newcastle upon Tyne.
authors.forename: A P
authors.initials: AP
authors.lastname: Murdoch
authors.forename: M
authors.initials: M
authors.lastname: Harris
authors.forename: M
authors.initials: M
authors.lastname: Mahroo
authors.forename: M
authors.initials: M
authors.lastname: Williams
authors.forename: W
authors.initials: W
authors.lastname: Dunlop
mesh_terms: D000328:Adult; D005260:Female; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007248:Infertility, Male / Q000209:etiology / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D013997:Time Factors