[Comparison of the bioequivalence of two allopurinol preparations].
Allopurinol generally is considered to be a problematic substance as to its bioavailability. To prove the quality, the in-vivo bioequivalence of an allopurinol (CAS 315-30-0) preparation (Cellidrin 300) in comparison to the standard preparation has been investigated. Both products were bioequivalent with regard to all relevant parameters such as AUC, tmax and Cmax.
Bührens
K
K
McKnight Laboratories, Hamburg.
Berndt
P
P
Hilgenstock
C M
CM
Baumann
W
W
Janzen
D
D
D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D006801:Humans; D008297:Male; D013607:Tablets; D013810:Therapeutic Equivalency
D013607:Tablets; D000493:Allopurinol
Zum Nachweis der Bioäquivalenz von zwei Allopurinol-Präparaten.