[Age-related differences in the effect of osmotic pressure on liver mitochondrial respiration in rats].
The subject under investigation is the influence of osmotic pressure of incubation medium (25-500 mM of sucrose) upon the respiration and the respiration control (RC) of mitochondria of the liver of rats aged 1, 3, 12 and 24 months when oxidizing succinate. In a medium with 0.3 M of sucrose the respiration rate under condition 3 (V3) and RC increased from the age of 1 to 12 months and decreased by 24 months. In a medium with 0.15 M of sucrose the age differences have not been observed. In a uncoupling state the osmotic dependence of the respiration of mitochondria of 1- and 12-month-old rats did not vary. It is assumed that with age there is a change in the rate of structural coupling of the carrier of adenine nucleotides with H(+)-ATP synthetase complex and (or) the viscosity of the matrix.
Udovikova
E A
EA
Lemeshko
V V
VV
D000375:Aging / Q000378:metabolism*; D000818:Animals; D003470:Culture Media; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D009997:Osmotic Pressure; D010101:Oxygen Consumption / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D003470:Culture Media
Vozrastnye razlichiia vliianiia osmoticheskogo davleniia na dykhanie mitokhondriĭ pecheni krys.