title: [Natural anti-PGF2alpha and anti-PGE2 antibodies in ischemic heart disease and hypertension].
abstract: The important role played by prostaglandins in the pathogenesis of coronary disease and essential hypertension is well known. The authors have attempted to reveal a relationship between blood levels of natural autoantibodies to PGF2 alpha and PGE2 and specific features of coronary disease and essential hypertension course and complications. A total of 87 subjects were examined, 23 of these--normal controls, 25 patients with myocardial infarction, 22 with angina pectoris, and 17 with essential hypertension. Solid-phase enzyme immunoassay was employed to detect anti-PGF2 alpha and anti-PGE2 antibodies. These antibodies were found in normal subjects, coronary patients and hypertensives. Blood levels of these antibodies correlated with some complications of coronary disease and essential hypertension. These results permit a hypothesis that the pathogenetic physiologic role of the detected natural antibodies to prostaglandins consists in their defense homeostatic function.
authors.forename: I M
authors.initials: IM
authors.lastname: Korochkin
authors.forename: I A
authors.initials: IA
authors.lastname: Verbitskaia
authors.forename: I N
authors.initials: IN
authors.lastname: Okuneva
authors.forename: V E
authors.initials: VE
authors.lastname: Krupnik
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Polevaia
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D003327:Coronary Disease / Q000209:etiology / Q000276:immunology*; D015237:Dinoprost / Q000276:immunology*; D015232:Dinoprostone / Q000276:immunology*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000276:immunology*; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D015237:Dinoprost; D015232:Dinoprostone
vernacular_title: Estestvennye antitela k prostaglandinam F2alpha i E2 pri ishemicheskoĭ bolezni serdtsa i gipertonicheskoĭ bolezni.