Protein kinase C in the promyelocytic leukemia cell differentiation of granulocytes.
When the leukemia cells in 14 patients with acute promyelocytic leukemia (APL) were induced by all-trans retinoic acid (RA) treatment, the activity of protein kinase C (PKC) increased with the differentiation. In the control cells, the activity of PKC was only 47 +/- 39.3 pmol.mg-1/min, while it was 149.3 +/- 150.1 pmol.mg-1/min after differentiation. There were 90.1 +/- 7.2% promyelocytes in the control group, and 8.9 +/- 5.6% in the induction group. Therefore, we think that there is a close correlation between PKC and the differentiation of promyelocytic leukemia cells.
Wu
X Z
XZ
Department of Hematology, Jinling Hospital, Nanjing.
Shao
G Y
GY
Chen
S R
SR
Huang
M E
ME
Wang
Z Y
ZY
D000328:Adult; D002454:Cell Differentiation / Q000187:drug effects; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000201:enzymology / Q000473:pathology*; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism*; D014212:Tretinoin / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D014212:Tretinoin; D011493:Protein Kinase C