Renal transplantation with a current T negative but historical T and/or B positive cross-match.
We report our experience of 36 renal transplanted patients against a current T negative allo-cross-match, but historical T and/or B positive allo-cross-matches, whatever the result of the current B cross-match. Additionally, we have determined the immunoglobulin class of the antibody directed against B and T lymphocytes. The graft survival rate did not differ between the 36 patients forming the study group, and the 229 patients transplanted within the same period with negative T and B, on current and historical sera, cross-matches. Within this study group there was no changes in graft survival rate for the following three subgroups, which were retrospectively defined: historical positive (14 patients) versus negative (22 patients) T cross-match, current positive (15 patients) versus negative (21 patients) B cross-match, and IgM (16 patients) versus IgG (20 patients) against B lymphocytes. In terms of transplant outcome, our policy was thus safe.
Guerin
C
C
Service of Nephrology, Centre Hospitalo-Universitaire de Saint-Etienne, Hôpital Nord, Saint-Priest-en-Jarez, France.
Pomier
G
G
Laverne
S
S
Fleuru
H
H
Le Petit
J C
JC
Berthoux
F
F
D000328:Adult; D000918:Antibody Specificity; D000961:Antilymphocyte Serum; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007518:Isoantibodies; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007518:Isoantibodies