Anthracycline antibiotic 2-hydroxyaclacinomycins. II. Production of 2-hydroxyaclacinomycins A and B by a new recombinant strain and their antitumor activities.
Anthracycline antibiotics 2-hydroxyaclacinomycins A and B were isolated and purified from the culture broth of a recombinant strain which was produced by protoplast fusion of two aclacinomycin-blocked mutants. 2-Hydroxyaclacinomycin B is a new compound for which chemical structure and the biological activity in vitro were determined. 2-Hydroxyaclacinomycins had a stronger antitumor activity against murine leukemic L1210 cells in mice than the parent antibiotic aclacinomycins.
Yoshimoto
A
A
Central Research Laboratories, Mercian Corporation, Kanagawa, Japan.
Johdo
O
O
Ishikura
T
T
Takeuchi
T
T
D015250:Aclarubicin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D011995:Recombination, Genetic
D000903:Antibiotics, Antineoplastic; D015250:Aclarubicin; C003424:2-hydroxyaclacinomycin A; C070608:2-hydroxyaclacinomycin B