[An experimental study on portal infusion of 5-fluorouracil].
We conducted these experiments to investigate the differences between continuous portal and one shot portal infusion of 5-fluorouracil (5-FU) using male Donryu rats. Continuous portal infusion of 5-FU (20 mg/kg/day x 5 days) revealed no remarkable side effects on the rats with significant decrease in the number of liver metastases generated by intraportal inoculation of ascites hepatoma AH60C. Consecutive 5-day administration of 5-FU (20 mg/kg x 5) by one shot method via spleen resulted in no metastases but caused death in 75% of rats because of severe leukopenia and dehydration. The rats receiving one shot infusion of 5-FU (33.3 mg/kg x 3, day 1, 3, 5) via spleen showed a significant decrease in the number of metastases without lethal side effects. Continuous portal infusion of 5-FU would be a safe and effective therapy to prevent liver metastases, whereas one shot portal infusion of 5-FU may give rise to severe side effects while preventing liver metastases.
Ishida
H
H
Second Dept. of Surgery, Tokyo Medical and Dental University, School of Medicine.
Iwama
T
T
Nishioka
Y
Y
Endo
S
S
Okubo
Y
Y
Imajo
M
M
Otomo
M
M
Mishima
Y
Y
D000818:Animals; D005472:Fluorouracil / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control / Q000556:secondary; D008297:Male; D011169:Portal Vein; D051381:Rats; D011919:Rats, Inbred Strains
D005472:Fluorouracil