[Effectiveness of tocopherol and anti-hypoxic agents in liver damage caused by antitubercular agents].
Two-week administration of isoniazid, rifampicin (50 mg/kg and pyrazinamide (1,5 g/kg) to white rats brings about liver affection characterized by a higher activity of alanine and aspartate aminotransferases, lipid peroxidation activation and bile production inhibition. With the liver affected by antituberculous drugs, protective action is provided by acetate tocopherol an antioxidant, and piracetam riboxin and pyriditol, antihypoxic agents.
Skakun
N P
NP
Slivka
Iu I
IuI
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology; D004195:Disease Models, Animal; D006520:Hepatitis, Animal / Q000188:drug therapy* / Q000209:etiology; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D007538:Isoniazid / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D008297:Male; D010889:Piracetam / Q000627:therapeutic use*; D011718:Pyrazinamide / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D051381:Rats; D012293:Rifampin / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D014810:Vitamin E; D011718:Pyrazinamide; D007290:Inosine Diphosphate; D007538:Isoniazid; D012293:Rifampin; D010889:Piracetam
Effektivnost' tokoferola i antigipoksantov pri porazhenii pecheni protivotuberkuleznymi preparatami.