title: Controlled clinical trials in stroke.
abstract: Reasons for the unsatisfactory number and reliability of most trials on the pharmacological treatment of acute cerebral ischemia are reviewed, focusing mainly on the clinical aspects of the issue. The opportunity of early intervention, supported by current pathophysiological hypotheses, is recognized. Past and recent Italian trials on ischemic stroke patients evaluated and treated within the first 6 h from onset are reported, also mentioning the results of a study including early cerebral angiography and SPECT (Single Photon Emission Computed Tomography). Early fibrinolytics associated to brain protecting agents are regarded as the future choice in clinical trials of acute cerebral ischemia.
authors.affiliation: Department of Neurosciences, University of Rome La Sapienza, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Fieschi
authors.forename: M
authors.initials: M
authors.lastname: Frontoni
authors.forename: C
authors.initials: C
authors.lastname: Argentino
authors.forename: F
authors.initials: F
authors.lastname: Orzi
authors.forename: D
authors.initials: D
authors.lastname: Toni
authors.forename: E
authors.initials: E
authors.lastname: Millefiorini
authors.forename: A
authors.initials: A
authors.lastname: Carolei
authors.forename: C
authors.initials: C
authors.lastname: Cavalletti
mesh_terms: D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D002986:Clinical Trials as Topic; D006801:Humans