title: Blood proteins do not promote adherence of coagulase-negative staphylococci to biomaterials.
abstract: We studied the effects of in vitro and in vivo coating of catheters with human blood proteins on binding of coagulase-negative staphylococci. Coating resulted in no enhancement of binding. Catheters coated in vitro bound fewer organisms than uncoated catheters. Host proteins do not enhance adherence of coagulase-negative staphylococci to biomaterials.
authors.affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: E
authors.initials: E
authors.lastname: Muller
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: D A
authors.initials: DA
authors.lastname: Goldmann
authors.forename: G B
authors.initials: GB
authors.lastname: Pier
mesh_terms: D001422:Bacterial Adhesion; D001672:Biocompatible Materials; D001798:Blood Proteins / Q000494:pharmacology*; D003030:Coagulase; D015169:Colony Count, Microbial; D006801:Humans; D066298:In Vitro Techniques; D013212:Staphylococcus epidermidis / Q000201:enzymology / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D001798:Blood Proteins; D003030:Coagulase