Recruitment of mononuclear cells into wounded skin: mechanism and modulation.
In conclusion, we have shown that the development of specialized endothelium that supports lymphocyte and monocyte adherence may be a common biologic event associated with tissue injury or disease processes in the skin. We have shown that the adherence process is potentially regulated by cytokines that are secreted by infiltrating mononuclear cells. Studies are now in progress to identify the putative endothelial ligands, their interactions with the receptors and the factors that lead to the expression of the adhesion molecules.
Cai
J P
JP
Department of Microbiology, University of Miami School of Medicine, FL 33101.
Harris
B
B
Falanga
V
V
Eaglstein
W H
WH
Mertz
P M
PM
Chin
Y H
YH
D000818:Animals; D002448:Cell Adhesion; D002455:Cell Division; D002478:Cells, Cultured; D016207:Cytokines / Q000502:physiology*; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology; D007375:Interleukin-1 / Q000502:physiology; D007963:Leukocytes, Mononuclear / Q000502:physiology*; D012867:Skin / Q000098:blood supply / Q000473:pathology*; D012879:Skin Physiological Phenomena; D013552:Swine; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D016207:Cytokines; D007375:Interleukin-1; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha