Amantadine inhibits an early, M2 protein-dependent event in the replication cycle of avian influenza (H7) viruses.
Analysis of the effects of amantadine during a single cycle of replication of A/FPV/Rostock virus in vitro showed that, as with other influenza A viruses, an M2 protein-dependent step early in infection was inhibited. No effect was observed on later steps in replication under the conditions used.
Kendal
A P
AP
Institute for Virology and Immunology, Philipps University, Marburg, Federal Republic of Germany.
Klenk
H D
HD
D000547:Amantadine / Q000494:pharmacology*; D001483:Base Sequence; D009980:Influenza A virus / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D008969:Molecular Sequence Data; D009154:Mutation; D014763:Viral Matrix Proteins / Q000096:biosynthesis / Q000187:drug effects / Q000235:genetics; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects; D000086082:Viroporin Proteins
D000547:Amantadine; D014763:Viral Matrix Proteins; D014764:Viral Proteins; C031540:M-protein, influenza virus; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins