[Intracellular metabolism in patients with insulin-dependent and non-insulin-dependent diabetes mellitus].
Slow infusion of neutral insulin causes in patients with insulin dependent and noninsulin dependent diabetes mellitus diverse changes in the levels of cAMP, cGMP and the cAMP/cGMP ratio in leukocytes in spite of one-type changes in the concentration of contrainsular hormones in the venous blood: in patients with noninsulin dependent DM a raised cAMP/cGMP factor was lowered whereas in patients with insulin dependent DM it was increased. The authors put forward for discussion the problem of the postreceptor mechanisms of tissue insulin resistance in noninsulin dependent DM and a possibility of the use of the above indices for differential diagnosis of DM types.
Iakovlev
G M
GM
Kozhemiakin
L A
LA
Rakov
A L
AL
Drygin
A N
AN
Iakovlev
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000627:therapeutic use; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009712:Nucleotides, Cyclic / Q000097:blood
D001786:Blood Glucose; D006728:Hormones; D007328:Insulin; D009712:Nucleotides, Cyclic
Vnutrikletochnyĭ metabolizm u bol'nykh insulinzavisimym i insulinnezavisimym tipami sakharnogo diabeta.