title: Prostaglandin synthesis is increased in selenium supplemented human mesangial cells despite suppression of phospholipase A2-activity.
abstract: Antioxidants play an important role in the regulation of phospholipid hydrolysis and arachidonate metabolism. Supplementation of cultured human mesangial cells with selenium resulted in suppression of phospholipase A2-activity and significantly increased production of three major prostaglandins. However, prostacyclin synthesis benefits most from selenium supplementation, suggesting that there is a specific action of selenium-dependent glutathione peroxidase on this pathway. Like in endothelial cells, production of platelet activating factor is significantly inhibited by selenium supplementation.
authors.affiliation: Department of Clinical Pathology, University of Erlangen-Nürnberg, FRG.
authors.forename: G
authors.initials: G
authors.lastname: Hampel
authors.forename: M
authors.initials: M
authors.lastname: Reinke
authors.forename: J
authors.initials: J
authors.lastname: Hren
mesh_terms: D002478:Cells, Cultured; D005920:Glomerular Mesangium / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D010972:Platelet Activating Factor / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D012643:Selenium / Q000494:pharmacology*
chemical_list: D010972:Platelet Activating Factor; D011453:Prostaglandins; D005979:Glutathione Peroxidase; D010741:Phospholipases A; D054467:Phospholipases A2; D012643:Selenium