Prospects for homologous recombination in human gene therapy.
The ideal approach to gene therapy of hereditary diseases or gene correction therapy is considered. The advantages, disadvantages and limits of gene targeting by homologous recombination are discussed with regard to its possible application in gene correction therapy and in comparison with retroviral-mediated gene complementation therapy.
Vega
M A
MA
Institut für Virologie and Immunbiologie der Universität, Würzburg, Federal Republic of Germany.
D015316:Genetic Therapy / Q000639:trends; D006801:Humans; D011995:Recombination, Genetic; D012190:Retroviridae / Q000235:genetics