[A comparative analysis of the action of zootoxins on the isolated heart].
A comparative analysis of cardiotropic activity of toxins has been studied in experiments on isolated heart of the poisonous animals from different systematic groups living on the territory of the USSR: reptiles (the venom of cobra, Vipera lebetina, Ancistrodon blomhoffi), amphibian (the venom of Bufo, Bombina, salamander), arachnids (the venom of Apis, Scolopendra, scorpion). The specific cardiotropic activity of the scorpion and Bufo venom has been discovered. The mechanisms of the cardiostimulative activity of scorpion venom have been found to be due to the activation of cellular adrenoreactive structures, and the Bufo venom to the activation of the intracellular calcium. The prospects of zootoxins using in cardiology for development of cardiotonic drugs and modelling the pathologic states in blood circulation system is substantiated.
Val'tseva
I A
IA
Krylov
V N
VN
Egorov
V V
VV
Sheshina
N P
NP
D000664:Amphibian Venoms / Q000494:pharmacology; D000818:Animals; D001180:Arthropod Venoms / Q000494:pharmacology; D002316:Cardiotonic Agents; D002415:Cats; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D012910:Snake Venoms / Q000494:pharmacology; D014118:Toxins, Biological / Q000494:pharmacology*
D000664:Amphibian Venoms; D001180:Arthropod Venoms; D002316:Cardiotonic Agents; D012910:Snake Venoms; D014118:Toxins, Biological
Sravnitel'nyĭ analiz deĭstviia nekotorykh zootoksinov na izolirovannoe serdtse.