title: Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid.
abstract: The effect of concentrations of linoleic acid (LA) on platelet aggregation was measured in seven healthy adult males. Subjects were randomly divided into two groups; these groups were fed natural food diets of identical composition except that one was high in LA (11.5% of energy) and low in oleic acid (OA) (7.4% of energy), the other was low in LA (4.5% of energy) and high in OA (15.7% of energy). The thresholds of ADP- and collagen-induced platelet aggregation were increased significantly by the high LA diet even though the intake of total fat and saturated fatty acids did not differ in these diets.
authors.affiliation: US Department of Agriculture/Agriculture Research Service, Western Human Nutrition Research Center, Presidio of San Francisco, CA 94129.
authors.forename: B J
authors.initials: BJ
authors.lastname: Burri
authors.forename: R M
authors.initials: RM
authors.lastname: Dougherty
authors.forename: D S
authors.initials: DS
authors.lastname: Kelley
authors.forename: J M
authors.initials: JM
authors.lastname: Iacono
mesh_terms: D000244:Adenosine Diphosphate / Q000008:administration & dosage / Q000494:pharmacology; D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D003094:Collagen / Q000008:administration & dosage / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D004042:Dietary Fats, Unsaturated; D008041:Linoleic Acids; D009829:Oleic Acids; D014801:Vitamin A; D014810:Vitamin E; D019301:Oleic Acid; D000244:Adenosine Diphosphate; D000990:Antithrombin III; D003094:Collagen; D019787:Linoleic Acid