title: [Optimal chips for megabase DNA sequencing].
abstract: The SHOM method (Sequencing by Hybridization with Oligonucleotide Matrix) developed in 1988 is a new approach to nucleic acid sequencing by hybridization to a octanucleotide matrix composed of an array of immobilized oligonucleotides. The original matrix proposed for sequencing by SHOM had to contain at least 65,536 octanucleotides. The present work describes a new family of matrices for sequencing, which allows one to reduce the number of synthesized oligonucleotides 5-15 times without essentially decreasing the resolving power of the method.
authors.forename: P A
authors.initials: PA
authors.lastname: Pevzner
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Lysov
authors.forename: K R
authors.initials: KR
authors.lastname: Khrapko
authors.forename: A V
authors.initials: AV
authors.lastname: Beliavskiĭ
authors.forename: V L
authors.initials: VL
authors.lastname: Florent'ev
authors.forename: A D
authors.initials: AD
authors.lastname: Mirzabekov
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000235:genetics*; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization
chemical_list: D004247:DNA
vernacular_title: Optimal'nye chipy dlia megabaznogo sekvenirovaniia DNK.