title: Failure to obtain long-term patency after implantation of fibrous polyurethane prostheses in the carotid arteries of rabbits.
abstract: Fibrous polyurethane prostheses were implanted in the carotid arteries and aortae of New Zealand white (NZW) and Chinchilla (CHIN) rabbits. No immediate post-implantation patency was obtained after implantation in the carotid arteries in NZW rabbits. In CHIN rabbits patency up to 1 week was obtained after carotid implantation. Attempts to increase patency rates by administration of 20 mg/kg body weight/day of both dipyridamol (DIP) and acetyl-salicylic acid (ASA) p.o., starting the week before implantation, had an adverse effect; prostheses became occluded within a few hours after implantation. Coagulation tests (Lee and White, Am J Med Sci 145:495-503, 1913) carried out with blood drawn from CHIN rabbits revealed hypercoaguability after administration of either 10 or 20 mg/kg body weight/day of both DIP and ASA compared to pre-medication values. Prostheses implanted in the aortae of both strains remained patent without anti-platelet-aggregation therapy for a 3-month observation period. It is concluded that in the NZW rabbit carotid implantation was not successful due to severe spasmic reactions and that in CHIN rabbits only very short-term patency could be obtained both with and without administration of 10 or 20 mg/kg body weight/day medication DIP and ASA.
authors.affiliation: Laboratory for Cell Biology and Histology, Catholic University of Nijmegen, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Hess
authors.forename: S
authors.initials: S
authors.lastname: Steeghs
authors.forename: C
authors.initials: C
authors.lastname: Jerusalem
authors.forename: B
authors.initials: B
authors.lastname: Braun
authors.forename: P
authors.initials: P
authors.lastname: Grande
mesh_terms: D000818:Animals; D001011:Aorta / Q000601:surgery; D001777:Blood Coagulation; D001807:Blood Vessel Prosthesis / Q000379:methods*; D002339:Carotid Arteries / Q000601:surgery; D008297:Male; D011140:Polyurethanes; D011475:Prosthesis Failure; D011817:Rabbits; D013997:Time Factors; D014654:Vascular Patency
chemical_list: D011140:Polyurethanes