Activation of human dermal fibroblasts by fibroblast growth factors (FGFs) and/or interleukin-1 beta (IL-1 beta).
Human dermal fibroblast proliferation was dependent of growth factors such as interleukin-1 (IL-1) and fibroblast growth factors (FGFs). These mediators, which induce proliferation of the cells in culture, were able to synergize when added in combination. This synergistic effect seems to be restricted to the mitogenic activity since IL-1-induced PGE2 release and interferon-beta 1 (IFN-beta 1) production by fibroblasts was inhibited in the presence of FGFs, which by themselves were unable to stimulate the production of IFN-beta 1 and the release of arachidonate metabolites from the fibroblasts even at high concentration.
Clement-Lacroix
P
P
U313 INSERM, Hôpital de la Pitié-Salpêtrière, Paris, France.
Friteau
L
L
Damais
C
C
D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D015232:Dinoprostone / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology*; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis*; D007375:Interleukin-1 / Q000502:physiology*; D008934:Mitogens / Q000502:physiology; D011994:Recombinant Proteins / Q000494:pharmacology; D012867:Skin / Q000166:cytology*
D007370:Interferon Type I; D007375:Interleukin-1; D008934:Mitogens; D011994:Recombinant Proteins; D005346:Fibroblast Growth Factors; D015232:Dinoprostone