Aluminium determination in the skin of patients with and without end-stage renal failure.
Aluminium (Al) concentration in the skin was determined by inductively coupled plasma optical emission spectrometry to look for a correlation between Al exposure and skin content in patients with end-stage renal failure. Skin Al concentrations were higher in dialyzed patients than in the nondialyzed group (1.02 +/- 0.30 vs. 0.26 +/- 0.10 micrograms/g; p less than 0.001). Moreover, in the dialyzed group, the patients treated for more than 100 months had a higher concentration of Al in the skin than the others (1.20 +/- 0.26 vs. 0.80 +/- 0.18 micrograms/g; p less than 0.05). Al skin content correlated better with the deferoxamine infusion test (DIT) than with Al blood plasma concentration. In conclusion, our data confirm that the DIT is a valuable tool for the evaluation of body Al content.
Subra
J F
JF
Service de Néphrologie, CHRU, Angers, France.
Krari
N
N
Tirot
P
P
Mauras
Y
Y
Balit
G
G
Van-Weydevelt
F C
FC
Allain
P
P
D000328:Adult; D000368:Aged; D000535:Aluminum / Q000097:blood / Q000378:metabolism* / Q000506:poisoning; D003676:Deferoxamine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects; D012867:Skin / Q000378:metabolism*
D000535:Aluminum; D003676:Deferoxamine