title: In vitro effect of larval stages of Ascaris lumbricoides on human blood clotting.
abstract: The effects of larval stages of Ascaris lumbricoides on human blood clotting was studied in vitro. Extracts and excretory/secretory products of third-stage larvae (L3) and late third-stage larvae (LL3) cultured from ova obtained from infected patients were analysed for anti-coagulant activity. Prothrombin time (PT) was prolonged by the addition of either whole extract of L3/LL3 or ES products of L3/LL3 as compared to controls. Partial thromboplastin time with kaolin (PTTK) was also prolonged on the addition of either extracts of ES products of L3/LL3. The prolongation of PTTK was significantly higher with extracts/ES products of L3 when compared to the extracts/ES products of LL3 (p less than 0.005). Thrombin time (TT) was prolonged by extracts of L3/LL3 and their ES products.
authors.affiliation: Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: N
authors.initials: N
authors.lastname: Malla
authors.forename: B A
authors.initials: BA
authors.lastname: Sofi
authors.forename: N K
authors.initials: NK
authors.lastname: Ganguly
authors.forename: R C
authors.initials: RC
authors.lastname: Mahajan
mesh_terms: D000818:Animals; D001200:Ascaris / Q000502:physiology*; D001777:Blood Coagulation; D006801:Humans; D007616:Kaolin; D007814:Larva / Q000502:physiology; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D013918:Thrombin Time
chemical_list: D007616:Kaolin