title: Ultrastructural morphology of folliculo-stellate cells in human pituitary adenomas.
abstract: Fifty-six pituitary adenomas were studied by electron microscopy in a search for the presence of folliculo-stellate cells (FSCs) with the aim of evaluating their prevalence and ultrastructural morphology. FSCs were scattered in two adenomas (one oncocytoma and one densely granulated GH cell adenoma) and were numerous in a sparsely granulated GH cell adenoma; their overall prevalence was 5.4%. Ultrastructural examination of the three neoplasms revealed that FSCs were hypertrophic element with abundant cytoplasm and organelles (in contrast to FSCs of the normal pituitary) and no obvious signs of neoplastic transformation. Junctional complexes between FSCs were similar to those described in the normal gland. Numerous follicular structures were lined by FSCs. FSCs in pituitary adenomas are probably nonneoplastic, reactive cells showing signs of hyperactivity, similar to FSCs found during pituitary hypersecretion and in estrogen-induced tumor.
authors.affiliation: Institute of Anatomy and Histology, University of Verona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Sbarbati
authors.forename: A
authors.initials: A
authors.lastname: Fakhreddine
authors.forename: C
authors.initials: C
authors.lastname: Zancanaro
authors.forename: L
authors.initials: L
authors.lastname: Bontempini
authors.forename: S
authors.initials: S
authors.lastname: Cinti
mesh_terms: D000236:Adenoma / Q000648:ultrastructure*; D004848:Epithelium / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D010911:Pituitary Neoplasms / Q000648:ultrastructure*