title: Studies on dressings for dental surgery use. Part 1: Effect of plasticizers on gelatin gel etching rate.
abstract: For quantitative evaluation of the absorption rate of dental dressings made of gelatin, a biopharmaceutical model of etching of gelatin gels in vitro has been elaborated. For the optimum etching conditions of gelatin gel columns 900 BAEE units per ml trypsin solution was used at a temperature of 25 degrees C. It has been found, that addition of glycerol and propylene glycol insignificantly reduces the etching rate of gelatin gels, whereas the PEG 400, PEG 1500 and PVAL increase resistance of the gels against the etching action of trypsin. In the model provided well repeatable results the coefficient of variation of the average gel etching rate remained within the range of 0.45-0.57%.
authors.affiliation: Department of Pharmaceutical Technology, Medical Academy, Wrocław, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Kubis
authors.forename: K
authors.initials: K
authors.lastname: Dybek
mesh_terms: D000042:Absorption; D005780:Gelatin; D005782:Gels; D008954:Models, Biological; D010511:Periodontal Dressings / Q000737:chemistry*; D010968:Plasticizers; D012996:Solutions
chemical_list: D005782:Gels; D010968:Plasticizers; D012996:Solutions; D005780:Gelatin