title: Tandem mass spectrometric approaches for determining exposure to alkylating agents.
abstract: Tandem mass spectrometric techniques have been developed for analysing alkylated purines in human urine. These techniques are designed with the objectives firstly of identifying unknown adducts derived from mixed exposures to alkylating agents, and secondly of quantifying these adducts with minimal sample purification.
authors.affiliation: MRC Toxicology Unit, Carshalton, Surrey, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Cushnir
authors.forename: J H
authors.initials: JH
authors.lastname: Lamb
authors.forename: A
authors.initials: A
authors.lastname: Parry
authors.forename: P B
authors.initials: PB
authors.lastname: Farmer
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000652:urine; D000477:Alkylating Agents / Q000378:metabolism*; D004784:Environmental Monitoring; D006147:Guanine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D013058:Mass Spectrometry
chemical_list: D000477:Alkylating Agents; C025946:3-methyladenine; D006147:Guanine; C008450:7-methylguanine; D000225:Adenine