Angiotensin II stimulates angiogenesis in the chorio-allantoic membrane of the chick embryo.
Angiotensin II was applied daily in doses of 67 or 670 ng to a section of the chick embryo chorio-allantoic membrane from day 7 to day 14 after fertilization of the eggs. During this one-week period, it caused a significant, dose-dependent increase in the vascular density index. The increase obtained with 670 ng daily was comparable to that after daily administration of 1.7 micrograms adenosine, a known stimulator of angiogenesis. The data suggest a possible role for angiotensin II as a mediator of vascular growth.
Le Noble
F A
FA
Department of Pharmacology, University of Limburg, Maastrict, The Netherlands.
Hekking
J W
JW
Van Straaten
H W
HW
Slaaf
D W
DW
Struyker Boudier
H A
HA
D000481:Allantoin; D000804:Angiotensin II / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000254:growth & development*; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply / Q000187:drug effects
D000804:Angiotensin II; D000481:Allantoin