title: Transcapillar metabolism of lipid- and watersoluble antioxidants as marker of chronical stress in coming population of circumpolar regions.
abstract: It was shown that the content of the lipid peroxide oxidation products and basic lipid and soluble antioxidant products in capillary and venous blood reflect the tissue trophy provision process in the chronic ecology stress condition. The high reactive oxygen species (ROS) generation in the xanthine-xanthine oxidase system is one of the important mechanisms which is responsible for capillary penetration disturbance and for accelerated development of inflammatory and non-inflammatory disease among immigrants to Circumpolar regions.
authors.affiliation: Institute of Clinical and Experimental Medicine, Academy of Medical Sciences, Novosibirsk, USSR.
authors.forename: V
authors.initials: V
authors.lastname: Kulikov
authors.forename: I
authors.initials: I
authors.lastname: Safronov
authors.forename: N
authors.initials: N
authors.lastname: Mikichur
authors.forename: N
authors.initials: N
authors.lastname: Zenkov
authors.forename: E
authors.initials: E
authors.lastname: Menshikova
authors.forename: L
authors.initials: L
authors.lastname: Kim
mesh_terms: D000222:Adaptation, Physiological; D001110:Arctic Regions; D002199:Capillary Permeability; D003080:Cold Temperature; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D010100:Oxygen / Q000378:metabolism*; D013312:Stress, Physiological / Q000097:blood; D013438:Sulfhydryl Compounds / Q000097:blood; D014527:Uric Acid / Q000097:blood*; D014810:Vitamin E / Q000097:blood*; D014969:Xanthine Oxidase / Q000097:blood*
chemical_list: D013438:Sulfhydryl Compounds; D014810:Vitamin E; D014527:Uric Acid; D008315:Malondialdehyde; D014969:Xanthine Oxidase; D010100:Oxygen