Metabolism of T-2 toxin by rat brain homogenate.
HT-2 toxin was the sole metabolite formed when T-2 toxin was treated with homogenate from brain without its blood content. Homogenate from brain with its full blood content produced--besides HT-2 toxin--T-2 triol, neosolaniol, 4-deacetylneosolaniol and T-2 tetraol, i.e. the same metabolites formed by incubation of T-2 toxin with whole rat blood.
Yagen
B
B
Department of Natural Products, School of Pharmacy, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Bergmann
F
F
Barel
S
S
Sintov
A
A
D000818:Animals; D001921:Brain / Q000378:metabolism*; D006867:Hydrolases / Q000378:metabolism; D006868:Hydrolysis; D008297:Male; D051381:Rats; D013379:Substrate Specificity; D013605:T-2 Toxin / Q000378:metabolism* / Q000031:analogs & derivatives; D014255:Trichothecenes / Q000378:metabolism
D014255:Trichothecenes; C038854:scirpentriol; C016009:neosolaniol; C070178:4-deacetylneosolaniol; D006867:Hydrolases; D013605:T-2 Toxin; C012351:HT-2 toxin