title: [Pharmacokinetics and tissue penetration of single-dose netilmicin used for antibiotic prophylaxis during colo-rectal surgery].
abstract: Pharmacokinetics and tissue penetration of netilmicin were studied after the use of a single dose (6 mg/kg) given for antibioprophylaxis in colo-rectal surgery. Thirteen patients, scheduled for elective surgery, were given 6 mg/kg IV netilmicin over 30 min, together with 1000 mg IV ornidazole. Netilmicin peak serum concentration (10 min after end of infusion) was 24.4 +/- 3.4 mg/l and trough level (24 h) was 0.9 +/- 0.5 mg/l. Plasma elimination half-life was 409 +/- 70 min, le volume apparent volume of distribution was 38 +/- 101 and total body clearance was 0.07 +/- 0.02 ml/min. Adequate netilmicin levels (5 greater than or equal to CMI 90 of involved pathogens Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus) were obtained in 100 per cent of patients in abdominal wall and epiploid fat, at time of opening, and in colonic wall at time of anastomosis. Adequate levels were obtained at time of closure in abdominal wall and epiploid fat in 92 to 100 per cent of patients. In situation of allergy to beta-lactam antibiotics, the use of netilmicin in combination with ornidazole may be recommended.
authors.affiliation: Laboratoire de Microbiologie, Hôpital Salvator, Marseille.
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: C
authors.initials: C
authors.lastname: Portet
authors.forename: P
authors.initials: P
authors.lastname: Bantz
authors.forename: J P
authors.initials: JP
authors.lastname: Brun
authors.forename: A
authors.initials: A
authors.lastname: Ruperti
authors.forename: M N
authors.initials: MN
authors.lastname: Mallet
authors.forename: B
authors.initials: B
authors.lastname: Sastre
mesh_terms: D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control*; D003108:Colonic Diseases / Q000601:surgery*; D005260:Female; D005454:Fluorescence Polarization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009428:Netilmicin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011300:Preoperative Care; D012002:Rectal Diseases / Q000601:surgery*; D013530:Surgical Wound Infection / Q000382:microbiology* / Q000517:prevention & control
chemical_list: D009428:Netilmicin
vernacular_title: Pharmacocinétique et diffusion tissulaire de la nétilmicine utilisée en dose unique pour l'antibioprophylaxie en chirurgie colo-rectale.