Natriuresis secondary to carotid chemoreceptor stimulation with almitrine bismesylate in the rat: the effect on kidney function and the response to renal denervation and deficiency of antidiuretic hormone.
Almitrine bismesylate simulates the effects of arterial hypoxia in producing a specific and long-lasting excitation of the peripheral arterial chemoreceptors. Previous work has shown that almitrine produces a diuresis and natriuresis when given intravenously to anaesthetised rats in a stable mannitol induced diuresis. This response is abolished by glossopharyngeal nerve section implying that it is afferently mediated via the carotid body chemoreceptors. We have studied further the efferent limb of this response. The diuresis and natriuresis occurs without significant detectable changes in effective renal plasma flow and glomerular filtration rate suggesting that it is produced mainly by inhibition of renal tubular sodium and water reabsorption. Almitrine produces a diuresis and natriuresis in rats after bilateral nephrectomy and transplantation of a kidney from a donor rat. This effect is not therefore efferently mediated by the renal nerves and probably involves a humoral agent. Almitrine produces a diuresis and natriuresis in rats after bilateral adrenalectomy and in rats with congenital hypothalamic diabetes insipidus indicating that neither adrenal hormones nor changes in antidiuretic hormone levels are implicated.
Bardsley
P A
PA
University Department of Medicine, Royal Hallamshire Hospital, Sheffield.
Johnson
B F
BF
Stewart
A G
AG
Barer
G R
GR
D015765:Almitrine / Q000494:pharmacology*; D000818:Animals; D002344:Carotid Body / Q000187:drug effects*; D002628:Chemoreceptor Cells / Q000187:drug effects*; D003714:Denervation; D003919:Diabetes Insipidus / Q000503:physiopathology; D004231:Diuresis / Q000187:drug effects; D007668:Kidney / Q000294:innervation; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000187:drug effects / Q000502:physiology; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D011910:Rats, Brattleboro / Q000502:physiology; D011919:Rats, Inbred Strains / Q000502:physiology; D014667:Vasopressins / Q000172:deficiency / Q000502:physiology
D014667:Vasopressins; D015765:Almitrine