Effect of sodium chloride on pirarubicin induced cell killing in P388 mouse leukemia cells.
The effect of sodium chloride on the cytotoxicity of 4'-O-tetrahydropyranyldoxorubicin (pirarubicin), a novel anthracycline derivative, was investigated on P388 mouse leukemia cells in vitro. The modifications in efficiency of uptake and killing action of pirarubicin were found to be dependent on the ionic strength of the medium. The relationship between intracellular drug accumulation into cells and cell killing was pointed out.
Furusawa
S
S
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Fujimura
T
T
Hayasaka
S
S
Kawauchi
H
H
Sasaki
K
K
Takayanagi
Y
Y
D000818:Animals; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D007941:Leukemia P388 / Q000378:metabolism*; D051379:Mice; D012965:Sodium Chloride / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D012965:Sodium Chloride; D004317:Doxorubicin; C027260:pirarubicin