title: Phase II trial of etoposide (V), adriamycin (A), and cisplatinum (P) in patients with metastatic gastric cancer.
abstract: The efficacy and toxicity of a combination of etoposide (100 mg/m2 i.v. on days 1 to 3), Adriamycin (20 mg/m2 i.v. on days 1 and 8) and cisplatinum (40 mg/m2 i.v. on days 2 and 8) repeated every 4 weeks as an outpatient regimen were assessed in 29 consecutive patients with metastatic gastric cancer with measurable disease. Five of these patients were refractory to 5-Fluorouracil, Adriamycin, and Mitomycin C. Three of these previously treated patients responded to the etoposide. Adriamycin, cisplatinum (VAP) therapy. An overall objective response rate of 72.5% was achieved, including 14% that were complete responses. The median duration of response was 6.0 months; median overall survival was 7.2 months, overall one-year survival was 34.4%. Hematologic toxicity was intense, particularly among patients with lower performance status. Three patients died as a consequence of nadir sepsis episodes.
authors.affiliation: Medical Oncology Section, Hospital das Clinicas, University of Sao Paulo Medical School, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Katz
authors.forename: R C
authors.initials: RC
authors.lastname: Gansl
authors.forename: S D
authors.initials: SD
authors.lastname: Simon
authors.forename: J
authors.initials: J
authors.lastname: Gama-Rodrigues
authors.forename: D
authors.initials: D
authors.lastname: Waitzberg
authors.forename: C J
authors.initials: CJ
authors.lastname: Bresciani
authors.forename: H W
authors.initials: HW
authors.lastname: Pinotti
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001855:Bone Marrow Diseases / Q000139:chemically induced / Q000453:epidemiology; D002945:Cisplatin / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage; D004341:Drug Evaluation; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D015996:Survival Rate
chemical_list: D005047:Etoposide; D004317:Doxorubicin; D002945:Cisplatin