title: Isotope limb blood flow measurement in patients undergoing peripheral laser angioplasty.
abstract: A technique of isotope limb blood flow (ILBF) measurement employing Technetium-labelled human albumin and a gamma camera, was used to assess limb perfusion in 19 patients undergoing percutaneous laser angioplasty, both before and one month after treatment. Twenty-three limbs with femoro-popliteal occlusions ranging in length from 3-35 cm (median 8 cm) were recanalized using an Nd-YAG laser and sapphire tipped optical fibre. Primary angiographic success was achieved in 19 lesions of which 6 re-occluded within the first month, and 13 remained patent with relief of symptoms. Clinically successful procedures were associated with a large increase in ILBF. However, normal blood flow was restored in only 54% of limbs. There was a slight decrease in limb perfusion after failed laser angioplasty but this was not statistically significant in this small series. Furthermore, there was no clinically apparent circulatory compromise, or need for urgent surgical bypass in failed cases. We conclude that ILBF is a useful means of assessing patients undergoing laser angioplasty, particularly for detecting small flow changes in patients who are unable to complete a standard exercise test. Its use can be recommended for assessing blood flow changes following other forms of limb revascularization.
authors.affiliation: Department of Radiology, Killingbeck Hospital, Leeds, UK.
authors.forename: S
authors.initials: S
authors.lastname: Ashley
authors.forename: S G
authors.initials: SG
authors.lastname: Brooks
authors.forename: A A
authors.initials: AA
authors.lastname: Gehani
authors.forename: P
authors.initials: P
authors.lastname: Thorley
authors.forename: A
authors.initials: A
authors.lastname: Parkin
authors.forename: R C
authors.initials: RC
authors.lastname: Kester
authors.forename: M R
authors.initials: MR
authors.lastname: Rees
mesh_terms: D000368:Aged; D016342:Angioplasty, Laser / Q000009:adverse effects; D001157:Arterial Occlusive Diseases / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005263:Femoral Artery; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery; D012008:Recurrence; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin