Dedifferentiated chondrosarcoma arising from osteochondromatosis. A case report.
Multiple hereditary osteochondromata has a higher incidence (5%-25%) of malignant change into chondrosarcoma than solitary osteochondroma (1%-2%); but only less than 10% of all chondrosarcomas may undergo dedifferentiated change into fibrosarcoma or malignant fibrous histiocytoma. We have a case presented here with osteochondromatosis who was found to have dedifferentiated chondrosarcoma arising from pelvic osteochondroma. Radical extra-compartmental resection was done and followed by chemotherapy and radiotherapy. Recurrence was found 3 months later. Early recognition of malignant change and adequate surgical resection with adjuvant therapy may prevent local recurrence and increase the survival rate.
Du
Y K
YK
Department of Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
Shih
H N
HN
Wang
J M
JM
Shih
C H
CH
D000328:Adult; D001859:Bone Neoplasms / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D002813:Chondrosarcoma / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D005097:Exostoses, Multiple Hereditary / Q000150:complications*; D006801:Humans; D008297:Male