title: The course of experimental Trypanosoma vivax infection in Uda sheep.
abstract: The course of experimental Trypanosoma vivax infection in eight Uda rams was studied. All the infected animals became parasitaemic 2 days post-inoculation and remained so throughout the study period. A three-phase disease pattern was recognized, i.e. acute, subacute and chronic stages lasting 17-85 days. The disease was characterized by fever and a terminal decrease in rectal temperature despite an increase in parasitaemia with time for rams with acute and subacute infections. Mean weight loss was most marked in subacute followed by chronic cases. Gross pathological changes observed in some infected rams with subacute and chronic trypanosomosis were oedema of the face and lower jaw, hydropericardium and atrophy of the pericardial fat. Petechial haemorrhages were observed on the surfaces of the heart and kidney of rams with acute infection. Anaemia was most severe in infected rams with acute disease, followed by those with subacute infections. Also, hypoproteinaemia was observed in all infected rams. Severe clinical findings associated with the death of all the infected rams during this study might indicate that the Uda breed of sheep in very susceptible to trypanosomosis. It is, therefore, recommended that this breed of sheep, which is strictly bred and reared in tsetse-free Sahel savannah, should not be introduced into endemic areas devoid of therapeutic cover and strict tsetse fly control.
authors.affiliation: Pathology Division, Nigerian Institute for Trypanosomiasis Research (NITR), Kaduna.
authors.forename: D B
authors.initials: DB
authors.lastname: Maikaje
authors.forename: A
authors.initials: A
authors.lastname: Sannusi
authors.forename: E K
authors.initials: EK
authors.lastname: Kyewalabye
authors.forename: D I
authors.initials: DI
authors.lastname: Saror
mesh_terms: D000208:Acute Disease; D000818:Animals; D001831:Body Temperature; D001947:Breeding; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood* / Q000473:pathology; D014353:Trypanosomiasis, African / Q000097:blood / Q000473:pathology / Q000662:veterinary*