[The significance of chorionic gonadotropin in regulating the antigen-independent differentiation of immunocompetent splenic cells].
The functional activity of fractionated splenocytes were investigated in the syngeneic transfer system. Chorionic gonadotrophin (CG) was injected to ovariectomized and noncastrated lymphocyte donors, the T or B lymphocytes being isolated on a column with a nylon fiber and by means of anti-BaO-serum accordingly. In some series CG was introduced only into recipients before their being irradiated and before syngeneic cells transferring. CG has been stated to be capable of influencing either independently or by means of ovarian hormones splenic B lymphocytes without exhibiting a significant effect on T helper precursors as well as radioresistant cells of the splenic stroma. The character of immunoregulating effect was completely dependent on the presence of ovaries in mice and on the hormone dose.
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D000818:Animals; D000941:Antigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010052:Ovariectomy; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects / Q000637:transplantation; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D014185:Transplantation, Isogeneic
D000941:Antigens; D006063:Chorionic Gonadotropin
Znachenie khorionicheskogo gonadotropina v reguliatsii antigennezavisimoĭ differentsirovki immunokompetentnykh kletok selezenki.