A high-performance liquid chromatographic assay for phenylmercuric nitrate in the presence of zinc ions and its application to an assessment of the stability of phenylmercuric nitrate in zinc sulphate and zinc sulphate and adrenaline eye drops.
A high-performance liquid chromatographic assay for phenylmercuric nitrate in the presence of zinc ions has been developed. Application of the assay to zinc sulphate and zinc sulphate and adrenaline drops before and after autoclaving demonstrates that the phenylmercuric nitrate is chemically degraded in the zinc sulphate and adrenaline drops.
Parkin
J E
JE
School of Pharmacy, Curtin University of Technology, Western Australia.
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004837:Epinephrine; D009883:Ophthalmic Solutions / Q000032:analysis*; D010663:Phenylmercury Compounds / Q000032:analysis / Q000737:chemistry*; D013431:Sulfates; D015032:Zinc; D019287:Zinc Sulfate
D009883:Ophthalmic Solutions; D010663:Phenylmercury Compounds; D013431:Sulfates; D019287:Zinc Sulfate; D015032:Zinc; C008860:phenylmercuric nitrate, basic; D004837:Epinephrine