title: [The convulsive activity of white rats after immunization with a conjugate of sidnofen and serum albumin].
abstract: The influence of white rats immunization by a covalent conjugate of serum albumin with sydnophen on the seizure activity in the single and repeated injections of pentylenetetrazole was investigated. The immunization lowered the seizure activity in single injections of threshold doses, (60 mg/kg) of pentylenetetrazole. The repeated daily injections of the drug in subthreshold doses (30 mg/kg) inhibited the process of "kindling" effects formation.
authors.forename: R A
authors.initials: RA
authors.lastname: Danilova
authors.forename: E V
authors.initials: EV
authors.lastname: Kustova
authors.forename: M F
authors.initials: MF
authors.lastname: Obukhova
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000276:immunology*; D007114:Immunization / Q000379:methods*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000276:immunology; D012709:Serum Albumin / Q000008:administration & dosage / Q000276:immunology*; D013558:Sydnones / Q000008:administration & dosage / Q000276:immunology*; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D012709:Serum Albumin; D013558:Sydnones; C013271:sydnophen; D010433:Pentylenetetrazole
vernacular_title: Sudorozhnaia aktivnost' belykh krys posle immunizatsii kon''iugatom sidnofena s serumal'buminom.