[The effect of microinjections of morphine and tramadol into the locus coeruleus on the nociceptive responses of the spinal cord neurons and on shifts in the arterial pressure].
Morphine and tramadol produces selective inhibition of the spinal noxious-evoked activity, but does not change blood pressure reactions. Antinociception was reversed by this structure injection of the naloxone. These data suggest that locus coeruleus realized the pain-relief effect of the opiate drugs.
Kolchin
V V
VV
Zaĭtsev
A A
AA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D004594:Electrophysiology; D008125:Locus Coeruleus / Q000187:drug effects* / Q000502:physiology; D008845:Microinjections; D009020:Morphine / Q000008:administration & dosage*; D009270:Naloxone / Q000008:administration & dosage; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology; D010646:Phentolamine / Q000008:administration & dosage; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D014147:Tramadol / Q000008:administration & dosage*
D009270:Naloxone; D014147:Tramadol; D009020:Morphine; D010646:Phentolamine
Vliianie mikroin''ektsiĭ morfina i tramadola v goluboe piatno na notsitseptivnye otvety neĭronov spinnogo mozga i sdvigi arterial'nogo davleniia.