MRI of hepatic iron deposition in patients with renal transplant.
Excess hepatic iron deposition was found in five of 15 (33%) renal transplant patients undergoing magnetic resonance (MR) screening for avascular necrosis of the femoral heads. Only one of these patients had overt liver disease. The number of prior blood transfusions was a significant factor for this deposition, whereas the age and sex of the patients, number and type of transplants, histocompatibility alleles (HLA), and years of hemodialysis and of chronic renal failure were not significant etiological factors. Liver/fat intensity ratios of less than 0.29 on T1-weighted images and ratios of less than 0.21 on T2-weighted images and a calculated T2 value of less than 35 ms were the best indicators of iron overload. Renal transplant patients are at great risk for excess hepatic iron deposition and MR imaging is a promising tool for the diagnosis of iron overload in this patient population.
Miller
F H
FH
Department of Radiology, Northwestern University Medical School, Chicago, Illinois.
Fisher
M R
MR
Soper
W
W
Gore
R M
RM
D000328:Adult; D005260:Female; D006486:Hemosiderosis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007501:Iron / Q000378:metabolism; D016030:Kidney Transplantation / Q000009:adverse effects; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male
D007501:Iron