[A comparative study of the immunological properties of peptidoglycans of different origins].
The action of peptidoglycans (PG) of different origin has been experimentally studied in vivo. In these experiments PG of bacterial origin, such as blastolysin (BL), and synthetic PG, viz. muramyldipeptide (MDP) and its analog glucosaminylmuramyldipeptide (GMDP) have been used. Their toxicity, allergenic action, their effect on the phagocytic activity of peritoneal exudate macrophages (PEM), the accumulation of antibody-producing cells in the spleen, antibody titer in the blood serum and delayed hypersensitivity to nonbacterial antigens have been determined. As revealed in this study, BL does not differ from MDP in its toxicity and allergenic action. The phagocytic activity of PEM under the influence of BL only insignificantly differs from their activity under the influence of MDP, but is lower than under the influence of GMDP. The adjuvant action of BL is somewhat higher than that of synthetic PG.
Zakharova
N S
NS
Shepeleva
I B
IB
Kalina
N G
NG
Britsina
M V
MV
Elkina
S I
SI
Andronova
T M
TM
Ermolova
E V
EV
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000276:immunology / Q000494:pharmacology / Q000633:toxicity; D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006020:Glycopeptides / Q000276:immunology / Q000494:pharmacology / Q000633:toxicity; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D007778:Lactobacillus; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010457:Peptidoglycan / Q000276:immunology / Q000494:pharmacology* / Q000633:toxicity; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D010457:Peptidoglycan; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C063429:glucosaminylmuramyl-2-alanine-D-isoglutamine; C025182:blastolysin
Sravnitel'noe izuchenie immunologicheskikh svoĭstv peptidoglikanov razlichnogo proiskhozhdeniia.