[Brain adrenoreceptors in rats with inherited arterial hypertension due to emotional stress].
For the study of genetic and physiological mechanisms of inherited stress-sensitive arterial hypertension, specific binding of ligands of alpha 1-, alpha 2- and beta-adrenoceptors was measured in 2 strains of rats: Wistar normotensive and ISSAH rats (rats with inherited stress-sensitive arterial hypertension). The maximal binding sites (Bmax) and apparent dissociation constants (Kd) were studied with the alpha 1-adrenergic antagonist 3H-prazosin, alpha 2-adrenergic agonist 3H-clonidine and 3H-dihydroalprenolol, a beta 1-receptor antagonist. Four brain regions were investigated: frontal cortex, hypothalamus, pons and medulla oblongata. In comparison with normotensive controls, hypertensive rats had significantly greater density of the alpha 1-adrenoceptors in the medulla oblongata. However, the number of hypothalamic alpha 1-adrenoceptors was significantly reduced in these animals. The same significantly lower alpha 2-adrenoreceptor density was found in the hypothalamus and the pons, and lower, beta-adrenoceptors density in the medulla oblongata. It was concluded that brain adrenoceptors are involved in the mechanisms of development of inherited stress-sensitive hypertensive syndrome.
Shishkina
G T
GT
Markel'
A L
AL
Naumenko
E V
EV
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003000:Clonidine / Q000378:metabolism; D004082:Dihydroalprenolol / Q000378:metabolism; D006973:Hypertension / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D011224:Prazosin / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D013045:Species Specificity; D013315:Stress, Psychological / Q000150:complications*
D011941:Receptors, Adrenergic; D004082:Dihydroalprenolol; D003000:Clonidine; D011224:Prazosin
Adrenoretseptory golovnogo mozga u krys s nasledstvennoĭ obuslovlennoĭ émotsional'nym stressom arterial'noĭ gipertenzieĭ.