Effects of aluminium salts on bone marrow chromosomes in rats in vivo.
Oral administration of aluminium sulphate to laboratory bred Rattus norvegicus for prolonged period induced dose dependent inhibition of dividing cells and an increase in chromosomal aberrations. The effect was not influenced by the duration of exposure. The toxicity of the two salts, aluminium sulphate and potassium aluminium sulphate, did not differ significantly at doses in which the metal contents were kept constant.
Roy
A K
AK
Human Genetics Unit, Centre of Advanced Study in Cell and Chromosome Research, Calcutta, India.
Sharma
A
A
Talukder
G
G
D000534:Alum Compounds / Q000633:toxicity*; D000818:Animals; D001682:Biological Availability; D001853:Bone Marrow / Q000187:drug effects*; D002869:Chromosome Aberrations / Q000139:chemically induced; D025063:Chromosome Disorders; D002875:Chromosomes / Q000187:drug effects*; D008297:Male; D008940:Mitotic Index / Q000187:drug effects; D051381:Rats
D000534:Alum Compounds; C041524:aluminum sulfate