Mouse dander-allergic bronchial asthma--a case report.
A case of mouse dander-allergic bronchial asthma is reported. A 47-year-old female professor of pharmacy has experienced severe chest discomfort, dyspnea and wheezing, and itching nose and eyes each time when she contacted with mice in recent months although she has done animal (mouse) experiments for many years without any difficulty. Those symptoms usually recovered spontaneously after removing the mice or using bronchodilator. The causal relationship between mouse dander and bronchial asthma was established, in addition to history of exposure, by a positive skin test, a strong RAST and overwhelming bronchial provocation test. The allergen was identified, by SDS-PAGE and immunoblotting to be a 21 Kd molecule.
Huang
J L
JL
Department of Pediatrics, National Taiwan University Hospital, Taipei, Republic of China.
Wang
S Y
SY
Lin
K L
KL
Hsieh
K H
KH
D000485:Allergens / Q000302:isolation & purification; D000818:Animals; D000830:Animals, Laboratory / Q000276:immunology; D001249:Asthma / Q000209:etiology*; D005260:Female; D006801:Humans; D051379:Mice / Q000276:immunology*; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology*
D000485:Allergens