[Protoscolicidal effect of some chemical agents and drugs against Echinococcus granulosus].
The present paper reports the protoscolicidal action of hydrastine, ether-acetic acid-ethanol admixture, H2O2, pyquiton and albendazole through in vitro or in vivo exposure, for 15 minutes and transplantation studies. The mortality of protoscolices in vitro and in vivo were 70.2% and 68.9% for 0.3% hydrastine, 56.8% and 56.2% for 10% ether-acetic acid-ethanol admixture, 6.0% and 8.8% for 0.3% H2O2; 6.1% for 0.004% pyquiton in vitro and 5.0% were 10% and 25% for 0.3% hydrastine, 30% and for 0.004% albendazole in vitro. The survival rates after transplantation of protoscolices 37.5% for 10% ether-acetic acid-ethanol admixture, 100% and 95% for 0.3% H2O2 respectively. Disruption of external plasma membrane, hook detachment, sucker deformity of protoscolices exposed to hydrastine were demonstrated by scanning electron microscopy. It is suggested that hydrastine exerts a profound intracellular effect on the protoscolex of E. granulosus of sheep and man, and might be a promising protoscolicide as adjuvant to hydatid surgery.
Chen
Q M
QM
Qinghai High Altitude Medical Science Institute.
Ye
Y C
YC
Chai
F L
FL
Jin
K P
KP
D000085:Acetates / Q000494:pharmacology; D015766:Albendazole / Q000494:pharmacology; D000470:Alkaloids / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D044182:Benzylisoquinolines; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D004444:Echinococcosis, Hepatic / Q000188:drug therapy; D004446:Echinococcus / Q000187:drug effects* / Q000648:ultrastructure; D000431:Ethanol / Q000494:pharmacology; D004986:Ether / Q000494:pharmacology; D051379:Mice; D011223:Praziquantel / Q000494:pharmacology
D000085:Acetates; D000470:Alkaloids; D044182:Benzylisoquinolines; D004365:Drugs, Chinese Herbal; D004986:Ether; D000431:Ethanol; D011223:Praziquantel; C013024:hydrastine; D015766:Albendazole