Radiotelemetric monitoring of hypothalamic gonadotropin-releasing hormone pulse generator activity throughout the menstrual cycle of the rhesus monkey.
Continuous monitoring of the electrophysiological manifestations of GnRH pulse generator activity was achieved by radiotelemetry throughout the menstrual cycles of unrestrained rhesus monkeys. The characteristic increases in hypothalamic multiunit activity (MUA volleys) associated with each LH pulse measured in the peripheral circulation were of lower frequency during the luteal phase than in the follicular phase of the cycle. Multiunit activity volley frequency increased as functional luteolysis progressed and achieved maxima of approximately one volley per hour within the first few days of the follicular phase. Unexpectedly, a dramatic decline in pulse generator frequency was observed coincidentally with the initiation of the preovulatory LH surge. Evidence is presented to support the conclusion that this deceleration of pulse generator activity is the consequence of the preovulatory rise in plasma estrogen concentration. As reported in women, a significant reduction in GnRH pulse generator frequency was observed at night during the follicular phase, but not during the luteal phase, of the menstrual cycle.
O'Byrne
K T
KT
Laboratory for Neuroendocrinology, University of Texas Medical School, Houston 77225.
Thalabard
J C
JC
Grosser
P M
PM
Wilson
R C
RC
Williams
C L
CL
Chen
M D
MD
Ladendorf
D
D
Hotchkiss
J
J
Knobil
E
E
D000818:Animals; D004958:Estradiol / Q000097:blood / Q000494:pharmacology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D007033:Hypothalamus, Middle / Q000187:drug effects / Q000502:physiology*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008253:Macaca mulatta; D008597:Menstrual Cycle / Q000187:drug effects / Q000502:physiology*; D010507:Periodicity; D011374:Progesterone / Q000097:blood / Q000494:pharmacology; D013686:Telemetry
D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone