title: Immunization response varies with intensity of acute lymphoblastic leukemia therapy.
abstract: Twenty-four children receiving maintenance chemotherapy for acute lymphoblastic leukemia were given booster doses of tetanus-diphtheria combined toxoids. One month later, 19 of the 24 children were given Haemophilus influenzae B oligosaccharide-cross-reacting material conjugate vaccine. Following immunization, all patients had protective antibody titers against tetanus, 92% had protective antidiphtheria titers, and 84% had protective titers against H influenzae. Preimmunization titers, postimmunization titers, and response to immunization varied according to the intensity of therapy. There was no correlation with duration of therapy or quantitative hematologic values in the peripheral blood. These observations support the recommendation that children treated for acute lymphoblastic leukemia should be immunized against H influenzae B.
authors.affiliation: Department of Pediatrics, Oregon Health Sciences University, Portland.
authors.forename: D
authors.initials: D
authors.lastname: Ridgway
authors.forename: L J
authors.initials: LJ
authors.lastname: Wolff
authors.forename: A
authors.initials: A
authors.lastname: Deforest
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001215:Asparaginase / Q000008:administration & dosage; D016667:Bacterial Capsules; D001428:Bacterial Vaccines / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D004166:Diphtheria Antitoxin / Q000032:analysis; D004168:Diphtheria Toxoid / Q000276:immunology*; D022422:Diphtheria-Tetanus Vaccine; D004338:Drug Combinations; D005260:Female; D018073:Haemophilus Vaccines; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007117:Immunization, Secondary; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000276:immunology; D011241:Prednisone / Q000008:administration & dosage; D013743:Tetanus Antitoxin / Q000032:analysis; D013745:Tetanus Toxoid / Q000276:immunology*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D004166:Diphtheria Antitoxin; D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D004338:Drug Combinations; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial; D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid; D014750:Vincristine; D003520:Cyclophosphamide; D001215:Asparaginase; D011241:Prednisone; D008727:Methotrexate; D003630:Daunorubicin