High-performance liquid chromatography with electrochemical detection of buprenorphine and its major metabolite in urine.
A procedure was developed for the simultaneous determination of buprenorphine and its major metabolite. N-desalkylbuprenorphine, by reversed-phase high-performance liquid chromatography with electrochemical detection. The detection limit is about 100 pg/ml for the major metabolite and 250 pg/ml for buprenorphine.
Debrabandere
L
L
Department of Toxicology, Katholieke Universiteit Leuven, Belgium.
Van Boven
M
M
Daenens
P
P
D002047:Buprenorphine / Q000031:analogs & derivatives* / Q000652:urine*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004594:Electrophysiology; D006801:Humans
D002047:Buprenorphine; C043585:norbuprenorphine