title: [Hyperbaric oxygenation and antioxidants in the complex intensive therapy of severe forms of pneumonia in children].
abstract: Hyperbaric oxygenation (HBO) was used in a complex intensive therapy of 194 children, aged 3 days to 3 years, with severe pneumonias. Initially the patients have revealed intensification of free radical processes (FRP) with a simultaneous decrease in the level of enzyme and non-enzyme protection and a drastic increase in gluco- and mineralocorticoid adrenal function. HBO and antioxidants (unithiol and alpha-tocopherol) yielded excellent and good results (a drop in FRP level and activation of enzyme antioxidant protection) in 75.8% of patients. HBO was ineffective in 17% of cases, in 7.2% of patients signs of the developing oxygen intoxication have been revealed. Control over the indexes of erythrocytes resistance to peroxide, extra-erythrocyte hemoglobin, total peroxidase plasma activity during HBO procedure makes it possible to detect early preclinical signs of acute oxygen intoxication onset.
authors.forename: G G
authors.initials: GG
authors.lastname: Zhdanov
authors.forename: V N
authors.initials: VN
authors.lastname: Nechaev
authors.forename: P A
authors.initials: PA
authors.lastname: Alipov
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D006931:Hyperbaric Oxygenation; D007223:Infant; D007231:Infant, Newborn; D011014:Pneumonia / Q000188:drug therapy / Q000628:therapy*
chemical_list: D000975:Antioxidants
vernacular_title: Giperbaricheskaia oksigenatsiia i antioksidanty v kompleksnoĭ intensivnoĭ terapii tiazhelykh form pnevmonii u deteĭ.