title: Comparison of the chromatographic characteristics of metabolites of tacrine hydrochloride in human serum and urine with those of in vitro metabolic products from hepatic microsomes.
abstract: There may be as many as five metabolites of THA in man, four corresponding to products in the rat. The study provides some evidence that one of major metabolites is 1-hydroxy-THA but lends no support to the putative oxidative deamination pathway.
authors.affiliation: Department of Medicine, Bristol Royal Infirmary, U.K.
authors.forename: C A
authors.initials: CA
authors.lastname: Truman
authors.forename: J M
authors.initials: JM
authors.lastname: Ford
authors.forename: C J
authors.initials: CJ
authors.lastname: Roberts
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013619:Tacrine / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000652:urine
chemical_list: D002800:Cholinesterase Inhibitors; D013619:Tacrine; C056424:velnacrine