title: Chiral high-performance liquid chromatography of aromatic cyclic dipeptides using cyclodextrin stationary phases.
abstract: A series of enantiomers of cyclic and linear dipeptides containing aromatic amino acids was prepared and chromatographed on beta- and gamma-cyclodextrin (CD) columns. The retention times, separation factor alpha and resolution values were calculated. The relevance of the distance of the chiral center from the phenyl ring for chiral resolution was studied. A model was developed using X-ray crystallographic data for an inclusion complex of beta-CD and the enantiomers of cyclic (Phe-Gly).
authors.affiliation: BOC Group Technical Center, Murray Hill, NJ.
authors.forename: J
authors.initials: J
authors.lastname: Florance
authors.forename: Z
authors.initials: Z
authors.lastname: Konteatis
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003196:Computer Graphics; D003505:Cyclodextrins; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification*; D008956:Models, Chemical; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D003505:Cyclodextrins; D004151:Dipeptides; D010456:Peptides, Cyclic