title: Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients.
abstract: Six drug-free obsessive-compulsive patients were given single photon emission computerized tomography scans before and during treatment with fluoxetine. The treatment significantly reduced the patients' "hyperfrontality," as determined by the ratio between medial-frontal and whole cerebral cortex blood flow, and significantly lowered ratings of obsessive-compulsive and anxiety symptoms.
authors.affiliation: Department of Psychiatry, Johns Hopkins Hospital, Baltimore, MD 21205.
authors.forename: R
authors.initials: R
authors.lastname: Hoehn-Saric
authors.forename: G D
authors.initials: GD
authors.lastname: Pearlson
authors.forename: G J
authors.initials: GJ
authors.lastname: Harris
authors.forename: S R
authors.initials: SR
authors.lastname: Machlin
authors.forename: E E
authors.initials: EE
authors.lastname: Camargo
mesh_terms: D000328:Adult; D001007:Anxiety / Q000188:drug therapy / Q000523:psychology; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology* / Q000627:therapeutic use; D005625:Frontal Lobe / Q000098:blood supply* / Q000187:drug effects; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005473:Fluoxetine