title: Bowel perforation and interstitial cystitis in childhood systemic lupus erythematosus.
abstract: A 13-year-old girl presented with abdominal pain, fever, dysuria, incontinence and pyuria and was subsequently diagnosed as having systemic lupus erythematosus (SLE) with extensive gastrointestinal involvement and an associated interstitial cystitis. Despite aggressive therapy with high dose prednisone and cyclophosphamide she developed a small bowel perforation and subsequently died. The combination of bowel symptoms and interstitial cystitis seems unique to the population with SLE, while the separate complication of bowel perforation carries an extremely poor prognosis in this group of patients.
authors.affiliation: Department of Pediatrics, Hospital for Sick Children, University of Toronto, ON, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Eberhard
authors.forename: A
authors.initials: A
authors.lastname: Shore
authors.forename: E
authors.initials: E
authors.lastname: Silverman
authors.forename: R
authors.initials: R
authors.lastname: Laxer
mesh_terms: D000293:Adolescent; D003108:Colonic Diseases / Q000188:drug therapy / Q000209:etiology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D003556:Cystitis / Q000150:complications* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000188:drug therapy / Q000209:etiology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D014657:Vasculitis / Q000150:complications / Q000188:drug therapy / Q000473:pathology
chemical_list: D003520:Cyclophosphamide; D011241:Prednisone