Activity of erdosteine on mucociliary transport in patients affected by chronic bronchitis.
The influence of erdosteine (a mucomodulator endowed with mucolytic and antioxidant properties) on human mucociliary transport (MCT) was investigated in a double-blind placebo controlled study. Sixteen former smokers affected by chronic bronchitis, preselected for their mucociliary responsiveness to an inhaled beta 2-agonist, were divided into two groups (matched by number, sex, age and FEV1%) and orally treated with placebo or erdosteine (300 mg t.i.d.) for 8 days. Their MCT was assessed by the bronchofiberscopy technique just before starting the treatment and at the end of the treatment. The pretreatment mucus transport velocity in these patients was significantly decreased with respect to healthy subjects. The erdosteine treatment induced a significant improvement of MCT while placebo was inactive (mean % variation +/- SE against their baseline values being +60.4 +/- 18.4 and -3.0 +/- 5.9, respectively). This peculiar activity of erdosteine on mucus transport may be of clinical usefulness in chronic bronchitic patients and it can be added to beta 2-agonist to restore the decreased MCT.
Olivieri
D
D
Istituto di Clinica delle Malattie dell'Apparato Respiratorio, Università degli Studi di Parma, Ospedale Rasori, Italia.
Del Donno
M
M
Casalini
A
A
D'Ippolito
R
R
Fregnan
G B
GB
D000368:Aged; D001991:Bronchitis / Q000188:drug therapy* / Q000378:metabolism; D001999:Bronchoscopy; D002908:Chronic Disease; D004311:Double-Blind Method; D005100:Expectorants / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects*; D009093:Mucus / Q000378:metabolism; D010919:Placebos; D012907:Smoking / Q000378:metabolism; D013864:Thioglycolates / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*
D005100:Expectorants; D010919:Placebos; D013864:Thioglycolates; D013876:Thiophenes; D005280:Fenoterol; C048498:erdosteine