[The role of vitamin E in the biosynthesis of ubiquinone (Q) and ubichromenol (QC) in rat liver].
Some peculiarities of ubiquinone (Q) biosynthesis in the livers of vitamin E-deficient rats induced in vitro by alpha-tocopherol and S-adenosylmethionine (SAM) were investigated. When [C3H3]SAM was used as a precursor, alpha-tocopherol added to the sample induced a marked elevation of the content of Q concomitantly with a drastic increase (2.82-fold) of specific radioactivity of Q in the liver as compared to control. Under identical conditions with 2-14C sodium acetate as precursor, exogenous alpha-tocopherol increased the content (by 31.4%) and specific radioactivity (by 65.2%) of Q in experimental samples, whereas the corresponding parameters of ubichromenol (QC) were essentially unchanged. SAM added to the incubation medium caused a marked increase in the content and specific radioactivity of both Q and QC as compared to control. Similar, and even more conspicuous changes were observed after combined administration of alpha-tocopherol and SAM. The role of vitamin E in the activation of methylation reactions at terminal steps of Q and QC biosynthesis in rat liver is discussed.
Donchenko
G V
GV
Kruglikova
A A
AA
Shavchko
L P
LP
Polishchuk
N L
NL
D000818:Animals; D002839:Chromans / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D012436:S-Adenosylmethionine / Q000378:metabolism; D014451:Ubiquinone / Q000096:biosynthesis*; D014810:Vitamin E / Q000378:metabolism*
D002839:Chromans; D014451:Ubiquinone; D014810:Vitamin E; C003740:ubichromenol; D012436:S-Adenosylmethionine
Izuchenie roli vitamina E v biosinteze ubikhinona (Q) i ubikhromenola (QC) v pecheni krys.