Increased mutation rate in bacteria overexpressing a cloned foreign gene.
Escherichia coli cells growing slowly as a result of the overexpression of a cloned foreign gene were shown to exhibit an increased mutation rate in the foreign gene as well as in several non-selected markers. This phenomenon is discussed in terms of the model proposed by Hall (1990).
Lukacsovich
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Institute of Biochemistry, Biological Research Center, Szeged, Hungary.
Venetianer
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D002876:Chromosomes, Bacterial; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics*; D005798:Genes, Bacterial; D007763:Lac Operon; D009154:Mutation; D010957:Plasmids; D014169:Transformation, Bacterial