title: Ontogeny of cholinergic ganglionic cells which take up L-3,4-dihydroxyphenylalanine and contain vasoactive intestinal polypeptide in the mouse tongue.
abstract: During the prenatal development of the mouse tongue, the intralingual ganglion was investigated histochemically and immunohistochemically for acetylcholinesterase (AChE) activity, the capacity to take up L-3,4-dihydroxyphenylalanine (L-DOPA) and vasoactive intestinal polypeptide (VIP)-like immunoreactivity. AChE-positive cells were first observed at gestational day 12, and AChE-positive neurons which take up L-DOPA were found at gestational day 14, while VIP-like immunoreactive neurons were not seen until gestational day 16. The present results suggested that the cholinergic neurons within the mouse tongue can take up L-DOPA from gestational day 14 and synthesize VIP from gestational day 16.
authors.affiliation: First Department of Oral Anatomy, Faculty of Dentistry, Osaka University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ichikawa
authors.forename: S
authors.initials: S
authors.lastname: Matsuo
authors.forename: S
authors.initials: S
authors.lastname: Wakisaka
authors.forename: M
authors.initials: M
authors.lastname: Akai
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis*; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D005724:Ganglia / Q000196:embryology* / Q000378:metabolism; D005865:Gestational Age; D007150:Immunohistochemistry; D051379:Mice; D008815:Mice, Inbred Strains; D009474:Neurons / Q000378:metabolism*; D014059:Tongue / Q000196:embryology / Q000294:innervation* / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000032:analysis*
chemical_list: D014660:Vasoactive Intestinal Peptide; D000110:Acetylcholinesterase; D004298:Dopamine