Single dose treatment of cystitis in children.
The efficacy of single dose treatment with trimethoprim compared to a 5-day course with the same drug was investigated in 100 children, 3-12 years, with isolated episodes of symptomatic non-febrile urinary tract infection. Cure, defined as sterile urine during the first week after treatment, was achieved in 74% (37/50) in the single dose group compared to 86% (43/50) in the 5-day treatment group. The difference was not statistically significant (chi 2 = 2.25, p = 0.134 two-tailed). The cure rates in relation to P-fimbriation of the infecting E. coli strains were similar in the two groups. During the 6 month follow-up, six children in each treatment group had one or more reinfections. Extended studies are needed to conclude if single dose and conventional treatment courses are equally effective.
Lidefelt
K J
KJ
Department of Paediatrics, Karolinska Institute, Sachs Children's Hospital, Stockholm, Sweden.
Bollgren
I
I
Wiman
A
A
D002675:Child, Preschool; D003556:Cystitis / Q000188:drug therapy* / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D012008:Recurrence; D014295:Trimethoprim / Q000627:therapeutic use*; D014296:Trimethoprim Resistance
D014295:Trimethoprim