title: Velocity and turbulence measurements past mitral valve prostheses in a model left ventricle.
abstract: Thrombogenesis and hemolysis have both been linked to the flow dynamics past heart valve prostheses. To learn more about the particular flow dynamics past mitral valve prostheses in the left ventricle under controlled experimental conditions, an in vitro study was performed. The experimental methods included velocity and turbulent shear stress measurements past caged-ball, tilting disc, bileaflet, and polyurethane trileaflet mitral valves in an acrylic rigid model of the left ventricle using laser Doppler anemometry. The results indicate that all four prosthetic heart valves studied create at least mildly disturbed flow fields. The effect of the left ventricular geometry on the flow development is to produce a stabilizing vortex which engulfs the entire left ventricular cavity, depending on the orientation of the valve. The measured turbulent shear stress magnitudes for all four valves did not exceed the reported value for hemolytic damage. However, the measured turbulent shear stresses were near or exceeded the critical shear stress reported in the literature for platelet lysis, a known precursor to thrombus formation.
authors.affiliation: Department of Mechanical Engineering, Florida International University, Miami 33199.
authors.forename: R T
authors.initials: RT
authors.lastname: Schoephoerster
authors.forename: K B
authors.initials: KB
authors.lastname: Chandran
mesh_terms: D001783:Blood Flow Velocity; D006350:Heart Valve Prosthesis; D008943:Mitral Valve; D008955:Models, Cardiovascular; D011140:Polyurethanes; D011474:Prosthesis Design; D015203:Reproducibility of Results; D012212:Rheology; D013314:Stress, Mechanical
chemical_list: D011140:Polyurethanes