The role of lipid peroxidation products in cumene hydroperoxide-induced Ca2+ efflux from mitochondria.
Cumene hydroperoxide-induced calcium release from mitochondria has been studied. Activation of lipid peroxidation by increasing concentrations of cumene hydroperoxide does not enhance calcium efflux induced by low (up to 50 microM) concentration of cumene hydroperoxide. It is concluded that cumene hydroperoxide-induced calcium release depends mainly on processes coupled to hydroperoxide reduction by an endogenous enzyme system.
Gogvadze
V G
VG
Institute of Theoretical and Experimental Biophysics, USSR Academy of Sciences, Pushchino.
Zhukova
A A
AA
D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats
D001555:Benzene Derivatives; C007164:cumene hydroperoxide; D002118:Calcium