Lovastatin therapy in hypercholesterolemia: effect on fibrinogen, hemorrheologic parameters, platelet activity, and red blood cell morphology.
The effect of lovastatin therapy on blood rheology was investigated in 26 hypercholesterolemic patients. Treatment with lovastatin was associated with a significant improvement in whole blood filtration time and a tendency toward normalization in red blood cell morphology. A significant increase was observed in fibrinogen level, in ADP-induced platelet aggregation, in the percentage of "big" platelets, and in platelet count. The viscosity of whole blood and plasma and the percentage of aggregated platelets did not change significantly. The cause for these hemorrheologic changes and their role in influencing the coronary risk of lovastatin-treated hypercholesterolemic patients should be further investigated.
Beigel
Y
Y
Department of Medicine A, Beilinson Medical Center, Petah Tiqva, Israel.
Fuchs
J
J
Snir
M
M
Green
P
P
Lurie
Y
Y
Djaldetti
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001809:Blood Viscosity / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004907:Erythrocyte Deformability / Q000187:drug effects*; D005340:Fibrinogen / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008148:Lovastatin / Q000627:therapeutic use*; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010976:Platelet Count / Q000187:drug effects*; D012212:Rheology
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005340:Fibrinogen; D008148:Lovastatin