title: Metabolism of verapamil in a family pedigree with deficient N-oxidation of trimethylamine.
abstract: The oxidative N-dealkylation of verapamil has been studied in a family of five members with two propositi with an inherited deficiency of trimethylamine N-oxidation (fish-odour syndrome). The results were assessed for possible co-segregation of the trimethylamine N-oxidation phenotype and any observed deficiency in oxidative N-dealkylation. The general pattern of metabolism of verapamil in the five subjects studied was similar to that reported in earlier investigations. Moreover, there were no differences between the two affected subjects and other family members with respect to the metabolic pattern. It is concluded that there is no functional segregation with respect to the mechanisms controlling trimethylamine N-oxidation and verapamil N-dealkylation.
authors.affiliation: Department of Pharmacology and Toxicology, St Mary's Hospital Medical School, London.
authors.forename: R
authors.initials: R
authors.lastname: Ayesh
authors.forename: H
authors.initials: H
authors.lastname: Kroemer
authors.forename: M
authors.initials: M
authors.lastname: Eichelbaum
authors.forename: R L
authors.initials: RL
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D003640:Dealkylation; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D008661:Metabolism, Inborn Errors / Q000235:genetics / Q000378:metabolism*; D008744:Methylamines / Q000378:metabolism*; D008875:Middle Aged; D009812:Odorants; D010084:Oxidation-Reduction; D010105:Oxygenases / Q000235:genetics; D010375:Pedigree; D011110:Polymorphism, Genetic; D014700:Verapamil / Q000378:metabolism*
chemical_list: D008744:Methylamines; D014700:Verapamil; D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming); C023336:trimethylamine