Antiulcerogenic and anti-inflammatory effects of emodin, isolated from Rhamnus triquerta wall.
Emodin, an anthraquinone derivative, isolated from the whole plant of R. triquerta, in 15 mg/kg dose (ip) exhibited anti-inflammatory activity against carrageenin-induced pedal inflammation in rats. In the same dosage it also showed antiulcer activity against 4 hr pylorus-ligated, aspirin and immobilization stress-induced gastric ulcers in rats. It decreased acid and pepsin output and augmented mucus secretion in terms of total carbohydrate: protein ratio in the gastric juice of aspirin treated pylorus-ligated rats, indicating that the antiulcerogenic effect of emodin may be due to its effect on gastric secretion.
Goel
R K
RK
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
Das Gupta
G
G
Ram
S N
SN
Pandey
V B
VB
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D004642:Emodin / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D007249:Inflammation / Q000517:prevention & control; D008297:Male; D051381:Rats; D014456:Ulcer / Q000517:prevention & control
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D004642:Emodin