Inhibitory effects of human salivary histatins and lysozyme on coaggregation between Porphyromonas gingivalis and Streptococcus mitis.
The effects of histatins on coaggregation between Porphyromonas gingivalis 381 and Streptococcus mitis ATCC 9811 were investigated by using a turbidimetric assay. The coaggregation activity was significantly inhibited by histatins 5 and 8 and strongly by lysozyme. Tritium-labeled histatin 8 bound to P. gingivalis cells but not to S. mitis cells.
Murakami
Y
Y
Department of Preventive Dentistry, Faculty of Dentistry, Osaka University, Japan.
Nagata
H
H
Amano
A
A
Takagaki
M
M
Shizukuishi
S
S
Tsunemitsu
A
A
Aimoto
S
S
D000595:Amino Acid Sequence; D001422:Bacterial Adhesion; D001439:Bacteroides / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D009113:Muramidase / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D012471:Salivary Proteins and Peptides / Q000494:pharmacology*; D013291:Streptococcus / Q000378:metabolism / Q000502:physiology*; D000099053:Histidine-Rich Glycoprotein
D011506:Proteins; D012471:Salivary Proteins and Peptides; D000099053:Histidine-Rich Glycoprotein; D009113:Muramidase