title: Lack of ciprofloxacin ototoxicity after repeated ototopical application.
abstract: The possible side effects of ototopically applied ciprofloxacin on inner ear function were investigated. The hearing function of pigmented guinea pigs was evaluated by daily frequency-specific evoked response audiometry after repeated application of the drug to both ears. Ciprofloxacin appeared to have no statistically significant effect on the hearing thresholds of the experimental animals.
authors.affiliation: Department of Otorhinolaryngology, University of Antwerp, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Claes
authors.forename: P J
authors.initials: PJ
authors.lastname: Govaerts
authors.forename: P H
authors.initials: PH
authors.lastname: Van de Heyning
authors.forename: S
authors.initials: S
authors.lastname: Peeters
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D007758:Ear, Inner / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000139:chemically induced*; D008297:Male; D012684:Sensory Thresholds / Q000187:drug effects
chemical_list: D002939:Ciprofloxacin