[The effect of cytostatics and corticosteroids on the phagocytic and fungicidal activity of the neutrophilic granulocytes].
In vitro tests have revealed that cytostatic agents and corticosteroids, introduced in vivo, produce an inhibitory effect on the phagocytic activity of mouse neutrophil granulocytes and on their capacity for the destruction of Candida albicans blastospores. The action of the above-mentioned preparations may be an important pathogenetic factor which when introduced into the animals, contributes to the development of candidiasis.
Pakhomova
E N
EN
Poliakova
M I
MI
Bykov
V L
VL
Karaev
Z O
ZO
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002176:Candida albicans; D002478:Cells, Cultured / Q000187:drug effects / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology; D003864:Depression, Chemical; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects* / Q000276:immunology
D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; C021650:hydrocortisone acetate; D003520:Cyclophosphamide; D006854:Hydrocortisone
Vliianie tsitostatikov i kortikosteroidov na fagotsitarnuiu i fungitsidnuiu aktivnost' neĭtrofil'nykh granulotsitov.