The effect of the antihistamine cimetidine on ultraviolet-radiation-induced tumorigenesis in the hairless mouse.
This experiment investigated the effect on ultraviolet (UV) radiation-induced tumorigenesis of feeding the histamine type 2 receptor antagonist, cimetidine, to Skh:HR mice. Cimetidine was fed to one group during a 70 day period of chronic UVR (5 days/week for 10 weeks), to a second group from the end of this period to the end of the experiment at 286 days and a third group was fed a control diet only throughout the experiment. Feeding mice cimetidine during the 70 day period of irradiation protected them against the later development of skin tumours.
Matheson
M J
MJ
Department of Veterinary Pathology, University of Sydney, NSW, Australia.
Reeve
V E
VE
D000818:Animals; D000970:Antineoplastic Agents; D002927:Cimetidine / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors; D014466:Ultraviolet Rays
D000970:Antineoplastic Agents; D002927:Cimetidine