[Alterations of the myocardium and adrenergic nerves of the isolated rat heart under conditions of total ischemia and normothermic cardioplegic reperfusion].
The increase of the ischemic period from 30 to 60 min did not enhance the degree of the contractural myocardial damage in connection with progression of "no reflow" phenomenon. Endogenous catecholamines do not play a decisive role in genesis of ischemic (reperfusion) heart damage. Cardioplegic reperfusion with a high K+ content results in a considerable loss of mediator from the adrenergic nerve fibres thus leading to the partial isolated heart desympathization.
Serov
R A
RA
Ivannikov
Iu V
IuV
Kashtélian
L S
LS
Egorova
M O
MO
Avilov
V V
VV
D000818:Animals; D002314:Cardioplegic Solutions / Q000494:pharmacology; D002395:Catecholamines / Q000502:physiology; D003327:Coronary Disease / Q000473:pathology; D006321:Heart / Q000294:innervation*; D006358:Hot Temperature; D066298:In Vitro Techniques; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000473:pathology*
D002314:Cardioplegic Solutions; D002395:Catecholamines; D011188:Potassium
Izmeneniia miokarda i adrenergicheskikh nervov izolirovannogo serdtsa krys pri total'noĭ ishemii i normotermicheskoĭ kardioplegicheskoĭ reperfuzii.