title: Identification of inducible damage-recognition proteins that are overexpressed in HeLa cells resistant to cis-diamminedichloroplatinum (II).
abstract: Two cis-diamminedichloroplatinum (II) (cisplatin)-inducible proteins [b 130 (approximately 130 kDa) and b95 (approximately 95 kDa]) in HeLa cells that recognize both the cisplatin-modified and u.v.-modified DNA were identified in this study. These damage-recognition proteins were overexpressed in cisplatin-resistant HeLa cells. The results suggest that the damage-recognition proteins are regulated in the cells in response to DNA damage, and they may be important for DNA repair and probably the emergence of cisplatin resistance.
authors.affiliation: Department of Biochemistry, Chang Gung Medical College, Taoyuan, Taiwan, Republic of China.
authors.forename: C C
authors.initials: CC
authors.lastname: Chao
authors.forename: S L
authors.initials: SL
authors.lastname: Huang
authors.forename: L Y
authors.initials: LY
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Lin-Chao
mesh_terms: D015139:Blotting, Southern; D015153:Blotting, Western; D002945:Cisplatin / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D004351:Drug Resistance; D005260:Female; D006367:HeLa Cells; D006801:Humans; D008970:Molecular Weight; D014466:Ultraviolet Rays
chemical_list: D004268:DNA-Binding Proteins; D004247:DNA; D002945:Cisplatin