[31P]MRS study of the protective effects of prostaglandin oligomers on forebrain ischemia in rats.
Two ester-type prostaglandin oligomeric compounds were synthesized, one from prostaglandin E1 (termed MR-356) and the other from prostaglandin B2 (termed OC-5186). Using in vivo [31P]MRS, the protective effects of these oligomers on forebrain ischemia (15 min) were evaluated in a rat model. Forebrain ischemia caused a decrease in intracellular high energy phosphates and intracellular pH (pHi) in the control and compounds-treated groups, but changes of these values in the OC-5186-treated group were significantly smaller than those in the control group. Moreover, the cerebral energy metabolism of the OC-5186-treated group returned to the preischemia level more rapidly than in the control group after forebrain ischemia. MR-356 had some effects, but the differences were not significant.
Kurata
M
M
Department of Anesthesiology, Mie University School of Medicine, Japan.
Okuda
M
M
Muneyuki
M
M
Ohnishi
S T
ST
D000255:Adenosine Triphosphate / Q000378:metabolism; D000527:Alprostadil / Q000031:analogs & derivatives*; D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000517:prevention & control*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D010710:Phosphates / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism*; D010758:Phosphorus; D011453:Prostaglandins / Q000494:pharmacology*; D011456:Prostaglandins B / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D010710:Phosphates; D011453:Prostaglandins; D011456:Prostaglandins B; D010725:Phosphocreatine; C060276:MR 356; C070097:OC 5186; D010758:Phosphorus; D000255:Adenosine Triphosphate; D000527:Alprostadil