A silicone pellet for continuous cocaine: comparison with continuous amphetamine.
An inexpensive silicone pellet is described for the continuous administration of cocaine for up to 5 days. Rats implanted with this pellet show minimal skin irritation and go through distinct behavioral stages, with an initial period of hyperactivity followed by motor stereotypies. Then, at 3-4 days after implantation, a variety of hallucinogen-like ("late-stage") behaviors appear, including limb flicks, sudden startle responses, and repetitive mid-air grasping movements. Compared to continuous d-amphetamine, continuous cocaine induces decreased motor stereotypies but heightened "late-stage" behaviors.
Lipton
J
J
Department of Psychology, University of California, Los Angeles, CA 90024.
Zeigler
S
S
Wilkins
J
J
Ellison
G
G
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage*; D003913:Dextroamphetamine / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004343:Drug Implants; D008297:Male; D011605:Psychoses, Substance-Induced / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains; D012828:Silicones
D004343:Drug Implants; D012828:Silicones; D003042:Cocaine; D003913:Dextroamphetamine