Effect of photoperiod on body weight and food intake of obese and lean Zucker rats.
Although the rat is usually not considered to be sensitive to photoperiod, under some experimental conditions photoperiod responses are unmasked. In addition, we have observed photoperiod-induced changes in body weight gain in lean and obese Zucker rats. In this experiment, body mass, food intake, body composition, brown adipose tissue (BAT) thermogenic state, and blood concentrations of corticosterone, insulin, and glucose were evaluated under one of two lighting conditions: a short (10 h light: 14 h dark) or a long (14 h light: 10 h dark) photoperiod. Plasma corticosterone and glucose concentrations measured under fasting conditions were unaffected by photoperiod in either genotype. The amount of BAT mitochondrial protein isolated was less in long photoperiod rats. BAT mitochondrial GDP binding was unaffected by photoperiod in the lean rats, but tended to be lower in long photoperiod obese rats than in short photoperiod obese rats. Although, photoperiod had no effect on daily food intake of rats exposed to the short versus long photoperiod, body mass was heaviest in obese rats raised in long photoperiod. Plasma insulin was increased in both lean and obese rats in long photoperiod. In addition, fat storage appeared to shift to internal depots in the lean rats exposed to long photoperiod. Our data demonstrate that photoperiod does have an effect on male Zucker rats with respect to body weight and fat distribution, with the obese rats being more sensitive to changes in photoperiod than the lean rats.
Larkin
L M
LM
Department of Nutrition, University of California, Davis 95616.
Moore
B J
BJ
Stern
J S
JS
Horwitz
B A
BA
D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003345:Corticosterone / Q000097:blood; D002149:Energy Intake; D006153:Guanosine Diphosphate / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008027:Light; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D051381:Rats; D011924:Rats, Zucker; D015430:Weight Gain
D001786:Blood Glucose; D007328:Insulin; D006153:Guanosine Diphosphate; D003345:Corticosterone