title: [The clinical significance of multifactor discrimination and analysis of maternal serum Cu, Zn, Cd, Mn contents in the diagnosis of abnormal fetus].
abstract: In this paper we present pair-comparison test with serum contents of Cu, Zn, Cd, Mn, Se in pregnant women with neural tube defects fetus (NTD), pregnant women with normal fetus and healthy with no pregnancy using Bayes Stepwise Discrimination Analysis and Fisher Discrimination Analysis. The results showed: NTD of fetus was related to deficiency of maternal serum in Cu, Zn, Mn and to excess of Cd. The maternal serum levels of Cu, Cd and Mn can be used as sensitive indicator to detect intrauterine abnormality at an early stage. The low levels of maternal serum in Zn and Se were not a specific indicator of NTD but a characteristic shared by all pregnant women. It is important to pay attention to supplying pregnant women at an early stage with Zn, Se to meet the needs of normal growth of the fetus and prevent foetal abnormality. With stepwise discrimination we established two equations by Cu, Zn, Cd, Mn used for distinguishing normal from abnormal fetus. The accordant rate of clinical discrimination with classification output for inside examples was 93%. In the equation established by Fisher principle Mn had the greatest rate, namely, 37.6%.
authors.affiliation: Faculty of public Health, Shandong Medical University, Jinan.
authors.forename: H M
authors.initials: HM
authors.lastname: Jiang
mesh_terms: D000328:Adult; D002104:Cadmium / Q000097:blood; D003300:Copper / Q000097:blood; D016002:Discriminant Analysis; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D008274:Magnesium / Q000097:blood; D009436:Neural Tube Defects / Q000175:diagnosis*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D014131:Trace Elements / Q000097:blood*
chemical_list: D014131:Trace Elements; D002104:Cadmium; D003300:Copper; D008274:Magnesium