title: Glucose tolerance and incidence of pancreatic islet cell antibodies in pregnancy in women with thyroid autoantibodies.
abstract: The prevalence of pancreatic islet cell antibodies (ICA) and complement fixing ICA (CF-ICA) and the effect of pregnancy of glucose tolerance was studied in 3 groups of women. One group had thyroid autoantibodies in serum detected in early pregnancy and subsequent development of postpartum thyroiditis (PPT), another group had thyroid autoantibodies without signs of PPT and the third group did not have thyroid autoantibodies or PPT. In the women with thyroid autoantibodies and PPT, ICA were found in one of 12 women (8%, 95% confidence limits 0-38%). In the group with thyroid autoantibodies without PPT, ICA were found in three of 27 women (11%, 2-29%), whereas two of 20 women without thyroid autoantibodies had ICA (10%, 1-32%), N.S. Where present, serum ICA levels were very low and similar in early pregnancy and 6 months postpartum. CF-ICA were only found in two women with thyroid autoantibodies without signs of PPT. In all groups glucose tolerance was impaired in pregnancy when compared to postpartum despite an increased insulin response to glucose ingestion. In pregnancy, however, glucose tolerance was more impaired in the women with thyroid autoantibodies and subsequent PPT, than in the women without thyroid autoantibodies. Postpartum glucose tolerance was similar in all groups. It is concluded, that the presence of thyroid autoantibodies in early pregnancy or development of PPT is not accompanied by an increased prevalence of islet cell antibodies, but women with thyroid autoantibodies and subsequent PPT have a significantly more reduced glucose tolerance in late pregnancy than women without thyroid autoantibodies.
authors.affiliation: Department of Obstetrics and Gynecology, Gentofte Hospital and Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: P J
authors.initials: PJ
authors.lastname: Hornnes
authors.forename: N
authors.initials: N
authors.lastname: Rasmussen
authors.forename: L
authors.initials: L
authors.lastname: Hegedüs
authors.forename: C
authors.initials: C
authors.lastname: Kühl
authors.forename: G F
authors.initials: GF
authors.lastname: Bottazzo
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007515:Islets of Langerhans / Q000276:immunology*; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy / Q000097:blood* / Q000276:immunology; D011644:Puerperal Disorders / Q000175:diagnosis* / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology*; D013966:Thyroiditis / Q000175:diagnosis* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; C024211:islet cell antibody