Discrimination of tetrahydroaminoacridine responders by a single dose pharmaco-EEG in patients with Alzheimer's disease.
We report the results of our study suggesting that a single dose pharmaco-EEG may predict treatment response to tetrahydroaminoacridine (THA) in Alzheimer's disease (AD). 14 AD patients and 7 age-matched neurologically healthy controls were selected for the study. AD patients had 7 weeks' THA treatment. 6 patients were regarded as responders and 8 patients as nonresponders, respectively. AD patients as well as controls had a baseline EEG recording and next day another recording 90 minutes after a peroral single dose of 50 mg THA. The relative change from the baseline in the alpha-theta ratio was the most sensitive discriminator of responders and nonresponders (P = 0.004, ANOVA).
Alhainen
K
K
Department of Neurology, University of Kuopio, Finland.
Partanen
J
J
Reinikainen
K
K
Laulumaa
V
V
Soininen
H
H
Airaksinen
M
M
Riekkinen
P
P
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology; D000704:Analysis of Variance; D004569:Electroencephalography / Q000379:methods*; D005583:Fourier Analysis; D006801:Humans; D013619:Tacrine / Q000627:therapeutic use*
D013619:Tacrine