title: Inhibition of growth of rat hepatoma by local injection of liposomes containing recombinant interleukin-2. Antitumor effect of IL-2 liposome.
abstract: Human recombinant interleukin-2 (IL-2) was entrapped in liposome, consisting of egg phosphatidylcholine (PC) and cholesterol. The peri-tumor injections of IL-2 liposome inhibited significantly the growth of solid tumor and prolonged the survival time of rats with solid tumors which were induced by a subcutaneous (s.c.) inoculation of AH-66 cells. Immunohistochemical staining of peritoneal exudate cells and tumor tissues revealed a marked accumulation of activated macrophages in and around the tumor tissues induced by the local injections of IL-2 liposome.
authors.affiliation: Second Department of Surgery, Hamamatsu University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Konno
authors.forename: A
authors.initials: A
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Tadakuma
authors.forename: S
authors.initials: S
authors.lastname: Sakaguchi
mesh_terms: D000818:Animals; D005122:Exudates and Transudates / Q000166:cytology; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use*; D008081:Liposomes; D008114:Liver Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
chemical_list: D007376:Interleukin-2; D008081:Liposomes; D011994:Recombinant Proteins