Lymphocyte activation in patients with acute myeloid leukaemia. Evidence for the presence of myeloblast antigen?
A group of 27 patients with acute myeloid leukaemia (AML), 15 with active disease and 12 in complete remission, were investigated for evidence of T cell activation. The parameters of T cell activation measured were the serum levels of soluble interleukin-2 receptor (sIL-2R), soluble CD4 (sCD4) and soluble CD8 (sCD8) molecules and the proportions of T cells expressing the cytotoxicity-linked cytoplasmic serine esterase. All patients studied with active disease had elevated sIL-2R and sCD8 molecules and an elevated proportion of T cells expressing serine esterase. Patients studied in complete remission also had elevated sIL-2R. sCD8 and serine-esterase-positive T cells, but values were lower than those studied in active disease. These patients were all studied in the absence of any ongoing or recent infection or exposure to homologous blood products, either of which could potentially affect these parameters. In the absence of any obvious alternative cause, we suggest these data indicate that AML leukaemia blast cells may be immunogenic and lead to the activation of cytotoxic T cells.
Lim
S H
SH
Department of Haematology, University College Hospital, London.
Worman
C P
CP
Goldstone
A H
AH
D000208:Acute Disease; D015703:Antigens, CD / Q000097:blood; D000951:Antigens, Neoplasm / Q000097:blood*; D004950:Esterases / Q000097:blood; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000276:immunology*; D008213:Lymphocyte Activation; D015375:Receptors, Interleukin-2 / Q000097:blood; D013601:T-Lymphocytes / Q000502:physiology*
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D015375:Receptors, Interleukin-2; D004950:Esterases; C022635:serine esterase