[Anti-ischemic action of a 1-hydroxy-2,2,6,6-tetramethylpiperidine derivative from a series of nitroxyl bioantioxidants].
The experiments have been performed on 216 Wistar rats to examine anti-ischaemic action of the 1-hydroxy-2,2,6,6-tetramethyl-piperidine derivative (I), whose antioxidant properties were, earlier shown for model systems. Introduction of I (10(-4) M) into the perfusion medium and the subsequent storage (37 degrees C) of isolated liver was shown to decrease the accumulation of lipid peroxidation products (MDA). Compound I administrated (5 x 10(-6)-10(-5) M) in perfuse medium of isolated (Langendorff method) and ischemized (30 min, 37 degrees C) heart improves contractile function (Pmax) and decreases end-diastolic pressure at postischaemic period. In vivo injection of I increases (12 mg/kg, i.p.) the number of rats survival after sublethal time (2.5 h) of liver total ischaemia, increase (35 mg/kg, i.p.) the number of rats survival and improves parameters of heart function after ischaemic shock (6 h ischaemia and reperfusion of limbs). The analog of I, corresponding amine, possessing no antioxidant properties also fails to exhibit any anti-ischaemic effect.
Bilenko
M V
MV
Komarov
P G
PG
Morgunov
A A
AA
Zhdanov
R I
RI
D000818:Animals; D000975:Antioxidants; D003327:Coronary Disease / Q000188:drug therapy*; D003497:Cyclic N-Oxides / Q000494:pharmacology / Q000627:therapeutic use*; D066298:In Vitro Techniques; D007511:Ischemia / Q000188:drug therapy*; D015227:Lipid Peroxidation; D008099:Liver / Q000098:blood supply*; D008297:Male; D009200:Myocardial Contraction; D015425:Myocardial Reperfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013113:Spin Labels
D000975:Antioxidants; D003497:Cyclic N-Oxides; D013113:Spin Labels; C001803:tempol
Protivoishemicheskoe deĭstvie 1-gidroksi-proizvodnogo 2,2,6,6-tetrametilpiperidina iz riada nitroksil'nykh bioantioksidantov.