Altered [3H]ryanodine binding is not associated with malignant hyperthermia susceptibility in terminal cisternae preparations from swine.
Based on comparisons between Pietrain malignant hyperthermia susceptible swine and Yorkshire control swine, other investigators have reported a 3-fold lower Kd for [3H]ryanodine binding to terminal cisternae in the malignant hyperthermia swine. However, the Kd of [3H]ryanodine binding did not correlate with malignant hyperthermia susceptibility when examined within the same strain (a Yorkshire/Duroc cross) in the present study. The values of Kd for the malignant hyperthermia susceptible and control swine in the present study were similar to those previously reported for the Pietrain strain, suggesting that the control strain chosen, not malignant hyperthermia susceptibility, accounts for what appeared to be a low Kd in Pietrain muscle.
Vita
G M
GM
Dept. of Anesthesiology, Hahnemann University, Philadelphia, PA 19102-1192.
Fletcher
J E
JE
Tripolitis
L
L
Rosenberg
H
H
Conti
P A
PA
D000818:Animals; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D066298:In Vitro Techniques; D008305:Malignant Hyperthermia / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism* / Q000648:ultrastructure; D012433:Ryanodine / Q000378:metabolism*; D013045:Species Specificity; D013552:Swine; D014316:Tritium
D014316:Tritium; D012433:Ryanodine