title: Plasma adenosine deaminase2 is a marker for human immunodeficiency virus-1 seroconversion.
abstract: Plasma adenosine deaminase2 (ADA2) has recently been proposed to be a marker for human immunodeficiency virus-1 (HIV) infection. We measured ADA2 levels in plasma from two groups of white homosexual males at 6-month intervals for a total of 2.5 years. One group consisted of 6 subjects who seroconverted for HIV, and the other consisted of 8 HIV seropositive patients who progressed from asymptomatic (CDC Groups II/III) to symptomatic (CDC Group IV) disease. Seroconversion was associated with a significant increase in plasma ADA2 which persisted throughout follow-up of 1.5 years. However, disease progression in HIV seropositive patients was not associated with any significant change in plasma ADA2. In conclusion, ADA2 may represent a unique marker for HIV seroconversion which does not change with later progression to symptomatic disease.
authors.affiliation: Division of Clinical Pharmacology, Brown University, Providence, Rhode Island.
authors.forename: J G
authors.initials: JG
authors.lastname: Niedzwicki
authors.forename: K H
authors.initials: KH
authors.lastname: Mayer
authors.forename: E
authors.initials: E
authors.lastname: Abushanab
authors.forename: D R
authors.initials: DR
authors.lastname: Abernethy
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D003430:Cross-Sectional Studies; D006679:HIV Seropositivity / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008297:Male
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D000243:Adenosine Deaminase