Negative control by Sandostatin on pancreatic and duodenal growth: a possible implication of insulin-like growth factor I.
This study was undertaken to evaluate the effects of Sandostatin, a potent somatostatin analogue, on pancreatic and intestinal growth and plasma and pancreatic levels of insulin-like growth factor I, a known growth factor. Rats weighing 320-330 g, equipped with an intravenous cannula were infused with either bovine serum albumin or Sandostatin at a dose of 5 micrograms kg-1 h-1 for 7 days. Sandostatin caused significant reductions in pancreatic and intestinal weights accompanied by decreases in total DNA, RNA in both organs and total protein in the intestine while total pancreatic enzymes were increased. Plasma cholecystokinin and insulin-like growth factor I were reduced whereas total insulin-like growth factor I pancreatic content was increased. It is suggested that Sandostatin may reduce growth of these two organs by decreasing cholecystokinin and insulin-like growth factor release and their specific effects at the pancreatic and duodenal cellular level.
Rivard
N
N
Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Québec, Canada.
Guan
D
D
Turkelson
C M
CM
Petitclerc
D
D
Solomon
T E
TE
Morisset
J
J
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002766:Cholecystokinin / Q000097:blood; D004386:Duodenum / Q000187:drug effects / Q000254:growth & development*; D004435:Eating / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D006131:Growth Inhibitors / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008297:Male; D015282:Octreotide / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects / Q000254:growth & development*; D051381:Rats; D011919:Rats, Inbred Strains
D006131:Growth Inhibitors; D007334:Insulin-Like Growth Factor I; D002766:Cholecystokinin; D015282:Octreotide