title: The effect of an antimicrobial releasing varnish on root demineralisation in situ. The influence of the demineralisation period.
abstract: Caries in exposed root surfaces is becoming a significant problem in dentistry. Varnish applications have interesting preventive possibilities against root caries. The effect of such a varnish, containing two antimicrobials, was studied on the demineralisation of roots with a twofold aim. Firstly, the efficacy of the varnish was investigated in situ as a function of the demineralisation period. Ten participants wore sound intact roots treated with the varnish in an intra oral appliance for 2, 4 and 6 weeks. Secondly, the effect of the varnish on root demineralisation after removal of the varnish was measured. The results showed that the reduction, in demineralization of about 80% after 2 weeks, decreased in magnitude with the length of the in situ demineralisation period. After 4 weeks there was no longer statistically significant difference compared with untreated roots. The acid attack by plaque was, however, substantial in this model; after 6 weeks in situ untreated roots were so strongly demineralised that microradiography was no longer possible anymore. In the second experiment in which the varnish was removed 2 days after application there was a trend toward a reduction of about 30% in root demineralisation after 2 weeks. This was not statistically significant when compared with no application.
authors.affiliation: Laboratory for Materia Technica, University of Groningen, The Netherlands.
authors.forename: E D
authors.initials: ED
authors.lastname: Huizinga
authors.forename: J
authors.initials: J
authors.lastname: Arends
mesh_terms: D000328:Adult; D002710:Chlorhexidine / Q000008:administration & dosage / Q000627:therapeutic use*; D003731:Dental Caries / Q000378:metabolism / Q000503:physiopathology*; D003804:Dentin / Q000737:chemistry / Q000187:drug effects; D003808:Dentin Solubility / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000737:chemistry; D010150:Paint; D013943:Thymol / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014092:Tooth Root / Q000737:chemistry / Q000187:drug effects*
chemical_list: D008903:Minerals; D013943:Thymol; D002710:Chlorhexidine