CHE1 UF serum cholinesterase phenotype in whites and non-whites from southern Brazil as determined by a new method.
A sample of 251 Whites and 818 Non-Whites, from Curitiba (southern Brazil), was typed with a new method with the aim of estimating the frequency of the CHE1*F allele. The frequency of this allele did not differ between Whites (0.60 +/- 0.34%) and Non-Whites (0.49 +/- 0.17%), being estimated as 0.51 +/- 0.15% for the whole sample. The use of the inhibitors DL-propranolol and RO2-0683 with alpha-naphthylacetate as substrate (at 37 degrees C) was efficient for discriminating between the CHE1 U and CHE1 UF phenotypes.
Alcântara
V M
VM
Department of Genetics, Federal University of Paraná, Curitiba, Brazil.
Chautard-Freire-Maia
E A
EA
Culpi
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D044383:Black People / Q000235:genetics*; D001938:Brazil; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D002802:Cholinesterases / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D005821:Genetic Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D009284:Naphthols; D010641:Phenotype; D011433:Propranolol / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D044465:White People / Q000235:genetics*
D002800:Cholinesterase Inhibitors; D009284:Naphthols; D000644:Quaternary Ammonium Compounds; C006266:Ro 20683; C027876:alpha-naphthyl acetate; D011433:Propranolol; D002802:Cholinesterases