title: Activity of clindamycin against Staphylococcus aureus and Staphylococcus epidermidis from four UK centres.
abstract: MICs of penicillin, methicillin, clindamycin, erythromycin, sodium fusidate and gentamicin were determined by an agar dilution method for 300 current isolates of Staphylococcus aureus and 100 of S. epidermidis, collected from four centres, and 38 stock strains of methicillin-resistant S. aureus (MRSA). All but one of the 300 current isolates of S. aureus were sensitive to clindamycin (MIC less than 0.5 mg/l), with an MIC90 of 0.12 mg/l. Of a total of 39 MRSA strains, 11 (28.2%) were resistant to clindamycin (MIC greater than 32 mg/l); all of these strains were also resistant to erythromycin. Ten of the 100 strains of S. epidermidis were resistant to clindamycin; they came from a reasonably equal geographical distribution and were also resistant to erythromycin. The results suggest that clindamycin might still be useful as a second-line agent for infections caused by S. aureus and S. epidermidis, although its activity against MRSA was limited to approximately two-thirds of the MRSA strains tested in this study.
authors.affiliation: Department of Medical Microbiology, Southmead Hospital, Bristol, UK.
authors.forename: D S
authors.initials: DS
authors.lastname: Reeves
authors.forename: H A
authors.initials: HA
authors.lastname: Holt
authors.forename: I
authors.initials: I
authors.lastname: Phillips
authors.forename: A
authors.initials: A
authors.lastname: King
authors.forename: R S
authors.initials: RS
authors.lastname: Miles
authors.forename: R
authors.initials: R
authors.lastname: Paton
authors.forename: R
authors.initials: R
authors.lastname: Wise
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
mesh_terms: D002981:Clindamycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000187:drug effects*; D006113:United Kingdom
chemical_list: D002981:Clindamycin; D004917:Erythromycin