Neurotoxicological effects of a pyrethroid formulation, fenvalerate in rats.
The effect of systemic treatment of a synthetic pyrethroid insecticide, fenvalerate (FV) was examined in adult female rats at different doses i.e. 5, 10, 20 mg/kg body weight by gavage for 21 consecutive days on regional brain levels of noradrenaline (NA), dopamine (DA), their acid metabolites: dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) by HPLC-EC system. Our results demonstrate pronounced inhibition of NA, DA, HVA & DOPAC levels in several brain regions which were neither dose related nor region specific.
Husain
R
R
Industrial Toxicology Research Centre, Lucknow, India.
Gupta
A
A
Khanna
V K
VK
Seth
P K
PK
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000032:analysis; D005260:Female; D009570:Nitriles; D011722:Pyrethrins / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D009570:Nitriles; D011722:Pyrethrins; C017690:fenvalerate