[Study of the action of tumor cell immunosuppressive factors on the production of cytokines by lymphocytes and macrophages and the mitogenic activity of interleukin-2].
The effect of immunosuppressive factors (ISF) derived from tumor cell lines (mastocytoma P-815, leukosis EL-4 and melanoma B16) on the production of interleukin-1 (IL-1) by macrophages and of interleukin-2 (IL-2) by splenocytes of BALB/C mice was investigated. We could show that treatment of above cells by the tumor products resulted in strong decrease of IL-2 production but did not affect IL-1 secretion. ISF inhibited the proliferation of BALB/C lymphoblasts caused by recombinant IL-2. Thus, one of the significant mechanisms of ISF action seems to be disturbance of monolymphokine cascade of lymphocyte activation.
Medvedev
A E
AE
Fuks
B B
BB
Iuriants
K
K
Dostman
U
U
Flegel'
A
A
D000818:Animals; D006801:Humans; D007108:Immune Tolerance; D007375:Interleukin-1 / Q000378:metabolism*; D007376:Interleukin-2 / Q000378:metabolism*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D014407:Tumor Cells, Cultured / Q000276:immunology / Q000378:metabolism
D007375:Interleukin-1; D007376:Interleukin-2
Issledovanie deĭstviia immunosupressornykh faktorov opukholevykh kletok na vyrabotku tsitokinov limfotsitami i makrofagami i na mitogennuiu aktivnost' interleĭkina-2.