HIV-1 infection and hematologic picture.
This review examines the wide spectrum of hematological abnormalities frequently observed in the peripheral blood and bone marrow of HIV-1 infected subjects. Several pathogenetic mechanisms have been implicated in the derangement of the hematopoietic system occurring during the course of HIV-1 infection: imbalance of the T-cell subpopulation (CD4/CD8 ratio), altered cytokine production by infected CD4+marrow cells, production of inhibitory factors by infected marrow stromal cells, antibody-mediated suppression of hematopoietic progenitors, direct infection of hematopoetic progenitors and/or precursors, and HIV-1 mediated suppression of CD34+ cell growth in the absence of a complete viral replication cycle. Each point is considered in the text, with particular attention to the mechanisms most likely to operate in the early stages of the syndrome.
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Institute of Microbiology, University of Bologna.
Zauli
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Furlini
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Giovannini
M
M
La Placa
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D002455:Cell Division; D016207:Cytokines / Q000096:biosynthesis; D015658:HIV Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D015497:HIV-1 / Q000502:physiology*; D006402:Hematologic Diseases / Q000150:complications*; D006412:Hematopoietic Stem Cells / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007958:Leukocyte Count; D009190:Myelodysplastic Syndromes / Q000150:complications*; D013601:T-Lymphocytes; D014779:Virus Replication
D016207:Cytokines