title: Immunoglobulin E, mast cells, endogenous antigens, and arthritis.
abstract: New aspects of the biology of the mast cell and its associated products may be important to the pathogenesis of arthritis. Mast cells may be activated in human arthritides as a result of a rapidly expanding list of peptides, including cytokines and neurotransmitters. The classic immunoglobulin E-coupled mast cell activation pathways may be used in the autoimmune diseases by way of autoantibody production involving the immunoglobulin E molecule itself. This can be shown to induce mediator release in vitro. The mast cell-derived products may play a role in both the early phases of synovitis as well as the chronic destructive phase.
authors.affiliation: State University of New York, Stony Brook.
authors.forename: B L
authors.initials: BL
authors.lastname: Gruber
mesh_terms: D000941:Antigens / Q000276:immunology*; D001168:Arthritis / Q000209:etiology*; D015550:Cell Degranulation; D006801:Humans; D007073:Immunoglobulin E / Q000502:physiology*; D008407:Mast Cells / Q000378:metabolism / Q000502:physiology*
chemical_list: D000941:Antigens; D007073:Immunoglobulin E