title: Stability of diltiazem in different biological fluids.
abstract: The hydrolysis of diltiazem in biological fluids: whole blood, plasma, and gastric fluid was investigated under conditions considered close to the physiological situation. The most significant rate of hydrolytic degradation was found in whole blood (half-life of 27 h), followed by plasma (half-life of 88 h), while the least significant degradation rate was observed in gastric fluid (half-life 153 h). The kinetic profiles of diltiazem hydrolysis indicate that hydrolytic degradation in the biological fluids makes a minimal contribution to the clearance and disposition of the drug.
authors.affiliation: Schering-Plough Research, Pembroke Pines, Miami, FL 33023.
authors.forename: A M
authors.initials: AM
authors.lastname: McLean
authors.forename: E A
authors.initials: EA
authors.lastname: Cefali
authors.forename: J S
authors.initials: JS
authors.lastname: Roden
authors.forename: M A
authors.initials: MA
authors.lastname: Gonzalez
authors.forename: M
authors.initials: M
authors.lastname: Bialer
mesh_terms: D001711:Biotransformation; D001826:Body Fluids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004110:Diltiazem / Q000032:analysis / Q000493:pharmacokinetics* / Q000494:pharmacology; D004355:Drug Stability; D006801:Humans; D066298:In Vitro Techniques
chemical_list: D004110:Diltiazem