title: Pyridoxine neuropathy. A four-year electrophysiological and clinical follow-up of a severe case.
abstract: In a 54-year-old male a severe sensory neuropathy was observed during treatment for pulmonary tuberculosis with isoniazid (400 mg/day) and pyridoxine (600 mg/day). Eight months after withdrawal from isoniazid the sensory symptomatology was still progressing, although muscle strength was never reduced. A sural nerve biopsy revealed marked loss of large myelinated fibres. Only when pyridoxine treatment was interrupted did a slow improvement begin. A clinical and electrophysiologic follow-up showed a very slow and still incomplete recovery after four years. The possibility of an unusual individual susceptibility to toxic effects of pyridoxine is considered.
authors.affiliation: Department of Clinical Neurophysiology and Neurological Clinic, 2nd School of Medicine, University of Naples, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Santoro
authors.forename: M
authors.initials: M
authors.lastname: Ragno
authors.forename: R
authors.initials: R
authors.lastname: Nucciotti
authors.forename: F
authors.initials: F
authors.lastname: Barbieri
authors.forename: G
authors.initials: G
authors.lastname: Caruso
mesh_terms: D004594:Electrophysiology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D011736:Pyridoxine / Q000009:adverse effects*; D013497:Sural Nerve / Q000473:pathology
chemical_list: D011736:Pyridoxine