[The effect of neutral polymers on glutamate dehydrogenase activity of mouse liver mitochondria upon administration of endotoxin].
It is shown that neutral polymers administered intraperitoneally to intact animals considerably affect glutamate dehydrogenase activity in the liver cell mitochondria as well as in the supernatant. Of the tested polymers, only polyvinyl methylacetamide and dextran inhibit a decrease in the level of mitochondrial enzyme activity which develops with administration of endotoxin. Polyvinyl pyrrolidone with molecular weight of 100 kDa, polyvinyl methylacetamide, dextran and polyvinyl caprolactam prevent an increase of glutamate dehydrogenase activity in the supernatant in case of endotoxin administration to animals. It is possibly a result of the effect of the mitochondrial structure stabilization by the above polymers. A physiological effect of polyvinyl pyrrolidone revealed as an effect on the activity level of mitochondrial glutamate dehydrogenase and in the supernatant after endotoxin administration to animals, depends on the molecular weight of the polymer.
Artiukhina
A I
AI
Galaev
I Iu
IIu
Shumskiĭ
V I
VI
D000818:Animals; D004731:Endotoxins / Q000633:toxicity*; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D011108:Polymers
D004731:Endotoxins; D011108:Polymers; D005969:Glutamate Dehydrogenase
Vliianie neĭtral'nykh polimerov na aktivnost' glutamatdegidrogenazy mitokhondriĭ pecheni mysheĭ pri vvedenii éndotoksina.