Behavioral effects of adenosine agonists: evaluation by punishment, discrete shuttle avoidance and activity tests in mice.
Behavioral effects of propentofylline and N6-(L-2-phenylisopropyl)-adenosine (PIA) were evaluated by operant behavior under a punishment situation, discrete shuttle avoidance response and ambulatory activity in mice. Propentofylline (3 mg/kg, s.c.) and PIA (0.01 mg/kg, s.c.) significantly decreased the punished response without producing a significant change in the non-punished response. Propentofylline and PIA reduced the increase in the punished response induced by caffeine (30 mg/kg) and diazepam (1 mg/kg). Propentofylline and PIA also reduced the increase of ambulation induced by caffeine. Furthermore, the single administration of propentofylline and PIA decreased the response rate and/or % avoidance in the discrete shuttle avoidance situation. However, the effective doses of propentofylline and PIA to reduce the ambulation-increasing effect of caffeine and to produce a change in the avoidance behavior were much higher than those effective for eliciting a significant change in the punished response. The present results suggest that there is an intimate interaction between central adenosine and benzodiazepine systems with regards to the change of punished response.
Haraguchi
H
H
Division for Behavior Analysis, Gunma University School of Medicine, Maebashi, Japan.
Kuribara
H
H
D000241:Adenosine / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D010660:Phenylisopropyladenosine / Q000494:pharmacology; D011678:Punishment; D012055:Reinforcement Schedule; D014970:Xanthines / Q000494:pharmacology
D014970:Xanthines; D010660:Phenylisopropyladenosine; D002110:Caffeine; C032114:propentofylline; D000241:Adenosine; D003975:Diazepam