Quantitative production of prostaglandin E2 and its metabolites by human fetal membranes.
Cultured amnion, choriodecidua and intact fetal membrane produced similar quantities of prostaglandin E2 (PGE2) (1-5 ng/ml). Choriodecidua and intact fetal membrane also produced very high levels of PGE2 metabolites (100-1000 ng/ml). The total production of PGE (PGE2 + PGE2 metabolites) was similar in intact fetal membrane and in choriodecidua, suggesting that the amnion, although a source of PGE2, contributes little to the overall PGE production by fetal membranes.
Khan
H
H
Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Sullivan
M H
MH
Helmig
R
R
Roseblade
C K
CK
Uldbjerg
N
N
Elder
M G
MG
D000650:Amnion / Q000378:metabolism; D002823:Chorion / Q000378:metabolism; D046508:Culture Techniques; D015232:Dinoprostone / Q000032:analysis / Q000378:metabolism*; D005321:Extraembryonic Membranes / Q000378:metabolism*; D006801:Humans
D015232:Dinoprostone