title: [The role of staphylococcal superinfection in viral hepatitis].
abstract: Viral hepatitis A was diagnosed in 69.35 percent of the 124 patients with viral hepatitides aged 15 to 62, 54.1 percent of these females and 45.9 percent males, and viral hepatitis B in 30.65 percent. The disease course varied in severity, was typical in all cases; the icteric form was observed in all the patients. An unfavorable pyoinflammatory premorbid background was present in 1/3 of the examinees. The studies have revealed that a staphylococcal superinfection with the icteric syndrome contributed to the pathogenesis of viral hepatitis. Antistaphylococcal agglutinins were detected in 65.6 percent of hepatitis A and in 73.7 percent of hepatitis B patients, and alpha antitoxins in 81.1 and 71.0 percent of patients, respectively. The disease severity correlated with high antitoxin titers, high antitoxin titers with a delayed convalescence of viral hepatitis A patients. Changes in the titers of antistaphylococcal agglutinins in hepatitis B patients were not rapid and their time course correlated with the terms of liver function recovery. The author comes to a conclusion that bacterial superinfection contributes to the pathogenesis of viral hepatitides, staphylococcal infection among other ones, that essentially influences the disease course.
authors.forename: G V
authors.initials: GV
authors.lastname: Mel'nik
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000373:Agglutinins / Q000032:analysis; D000907:Antibodies, Bacterial / Q000032:analysis; D006506:Hepatitis A / Q000209:etiology* / Q000276:immunology; D006509:Hepatitis B / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008875:Middle Aged; D009894:Opportunistic Infections / Q000209:etiology* / Q000276:immunology; D013203:Staphylococcal Infections / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013210:Staphylococcus / Q000276:immunology
chemical_list: D000373:Agglutinins; D000907:Antibodies, Bacterial
vernacular_title: Znachenie stafilokokkovoĭ superinfektsii v klinike virusnykh gepatitov.