title: Clinical features and comprehensive treatment of late stage radiation skin injuries.
abstract: 105 patients with late stage radiation skin injury were treated from 1970 to 1986, using drugs combined with surgical intervention according to the clinical features of the injury. Drug therapy consisted of topical application of urea, antibiotics, trypsin and elastase, and systematic use of alpha 2-Macroglobulin. Of 62 patients receiving medication, 55 (88.7%) were completely or basically treated and 7 failed. Of 51 lesions of 43 patients receiving surgical treatment, 47 healed by first intention. In 4 patients, necrosis of partial and/or peripheral skin flaps healed after renewed repair.
authors.affiliation: Institute of Radiation Medicine, Shanghai Medical University.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Weng
authors.forename: Z L
authors.initials: ZL
authors.lastname: Lin
authors.forename: H S
authors.initials: HS
authors.lastname: Zhang
authors.forename: M L
authors.initials: ML
authors.lastname: Sheng
authors.forename: J Y
authors.initials: JY
authors.lastname: Ma
authors.forename: C F
authors.initials: CF
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D062109:Dermatologic Surgical Procedures; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000628:therapy*; D011855:Radiodermatitis / Q000628:therapy*; D012883:Skin Ulcer / Q000209:etiology / Q000628:therapy; D014508:Urea / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014508:Urea