title: Granulocytic sarcoma of the ovary. An unusual case presentation.
abstract: We report an unusual occurrence of granulocytic sarcoma presenting as an ovarian mass in a 46-year-old woman with a history of dysplastic nevus syndrome. During workup of the ovarian mass, the diagnosis of acute myelogenous leukemia was made. A fine-needle aspirate of the ovarian mass showed granulocytic sarcoma. The patient died of complications of the acute leukemia a short time later. A postmortem examination was performed, which confirmed the nature of the ovarian mass as a granulocytic sarcoma. Material was obtained for flow cytometry, immunohistochemical and histochemical studies, and electron microscopy. Ploidy analysis of the tumor showed it to be diploid with an S phase of 4.8% and a G2 + M ratio of 0.5%. To our knowledge, there is only one previous report of a primary ovarian presentation of granulocytic sarcoma, and only four cases in which granulocytic sarcoma was diagnosed by fine-needle aspiration cytology. The association between dysplastic nevus syndrome and acute myeloid leukemia in this case is discussed with reference to a review of the metachronous association between melanoma and leukemia as described in the literature.
authors.affiliation: Department of Pathology, Foothills Hospital, Calgary, Alberta, Canada.
authors.forename: A M
authors.initials: AM
authors.lastname: Magliocco
authors.forename: D J
authors.initials: DJ
authors.lastname: Demetrick
authors.forename: A R
authors.initials: AR
authors.lastname: Jones
authors.forename: A E
authors.initials: AE
authors.lastname: Kossakowska
mesh_terms: D001707:Biopsy, Needle; D002102:Cadaver; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007951:Leukemia, Myeloid / Q000201:enzymology / Q000473:pathology*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000473:pathology*
chemical_list: D002265:Carboxylic Ester Hydrolases; C019873:chloroacetate esterase