Metabolic disposition of 14C-metanil yellow in guinea pigs.
The absorption, metabolism and excretion of 14C-metanil yellow was studied in guinea pigs. Following administration of a single po dose of 5 mg dye (7.6 mu Ci)/kg body weight, 83.4% was excreted through urine and feces within 96 h with the majority accounted for in feces. Liver, kidney and spleen did not have marked accumulation of counts, whereas testes and gastrointestinal tract retained 1.9 and 9.7% of the radioactivity, respectively. Analysis of urine and feces detected 2 azo-reduction metabolites of metanil yellow which were characterized by TLC and IR, NMR and mass spectroscopic studies as metanilic acid and p-aminodiphenylamine.
Singh
R L
RL
Department of Biochemistry, College of Basic Sciences and Humanities GB Pant University of Agriculture and Technology, Pantnagar, India.
Khana
S K
SK
Singh
G B
GB
D000818:Animals; D001391:Azo Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D002250:Carbon Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000652:urine; D004396:Coloring Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005243:Feces / Q000737:chemistry; D006168:Guinea Pigs; D008297:Male; D013997:Time Factors
D001391:Azo Compounds; D002250:Carbon Radioisotopes; D004396:Coloring Agents; C005108:metanil yellow