[Effect of stepped isovolemic hemodilution on some parameters of systemic and cerebral hemodynamics under normal conditions and in a sharp rise of arterial pressure].
It was demonstrated in rabbit experiments that in decrease of the hematocrit value by more than 10% the increase of arterial pressure induced by intravenous noradrenaline injection and its additional rise are significantly higher than in the controls. In spite of that, the breakthrough of autoregulation of local cerebral blood flow occurred much less frequently, was less pronounced, and attended by significantly less damage to the permeability of the blood-brain barrier to labelled blood albumin. This phenomenon can be explained by the fact that in reduced blood viscosity the pseudoturbulence of its flow, and the hydrodynamic resistance of blood increase due to which it reaches the microcirculatory bed at a lesser pressure than in the controls. The results of the study substantiate the expediency of blood-letting as a therapeutic measure for patients with hypertensive disease, in hypertensive crises also.
Gannushkina
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Antelava
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D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006438:Hemodilution / Q000379:methods*; D006439:Hemodynamics / Q000502:physiology*; D008297:Male; D010953:Plasma Volume; D011817:Rabbits; D012016:Reference Values
Vliianie stupenchatoĭ izovolemicheskoĭ gemodiliutsii na nekotorye parametry sistemnoĭ i i tserebral'noĭ gemodinamiki v norme i pri ostrom pod "eme arterial'nogo davleniia.