title: Dynamic imaging of contrast enhancement in brain tumors.
abstract: Gadolinium-DTPA has been shown to be a good probe for demonstrating defects in the blood-brain barrier, but it has a rapid rate of elimination so that peak circulating levels are short-lived. In this study ultrafast echo-planar imaging has been used in combination with a bolus injection of gadolinium-DTPA to evaluate perfusion within brain tumors and to assess the degree of disruption of the blood-brain barrier. The temporal profile of enhancement may allow discrimination between different tumor types.
authors.affiliation: Department of Physics, University of Nottingham, United Kingdom.
authors.forename: P R
authors.initials: PR
authors.lastname: Bullock
authors.forename: P
authors.initials: P
authors.lastname: Mansfield
authors.forename: P
authors.initials: P
authors.lastname: Gowland
authors.forename: B S
authors.initials: BS
authors.lastname: Worthington
authors.forename: J L
authors.initials: JL
authors.lastname: Firth
mesh_terms: D001812:Blood-Brain Barrier; D001921:Brain / Q000098:blood supply; D001932:Brain Neoplasms / Q000098:blood supply / Q000175:diagnosis*; D003287:Contrast Media; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008833:Microcirculation; D009942:Organometallic Compounds; D004369:Pentetic Acid
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA