title: Some extensions to a new approach for interim analysis in clinical trials.
abstract: There already exists many methods for group sequential analysis of clinical trials. A new approach suggests to preserve the overall type I error alpha by requiring that a succession of interim analyses be significant at the alpha level. In this paper, this procedure is extended. A rule for early acceptance of H0 is presented, with an extension for flexible number and times of analyses. A real example is given.
authors.affiliation: INSERM U 169, Villejuif, France.
authors.forename: B
authors.initials: B
authors.lastname: Falissard
authors.forename: J
authors.initials: J
authors.lastname: Lellouch
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D003627:Data Interpretation, Statistical; D008432:Mathematical Computing; D011336:Probability; D012107:Research Design