A 3-month comparison of 1% and 2% carteolol and 0.5% timolol in open-angle glaucoma.
Carteolol, a nonselective beta-adrenergic antagonist with intrinsic sympathomimetic activity, was compared in 1% and 2% topical solutions with 0.5% timolol in 105 patients with primary open-angle glaucoma. In this double-masked, randomized 3-month trial, all three preparations significantly lowered intraocular pressure throughout the study, with no significant differences being observed. There were also no significant differences among the three preparations with regard to ocular or systemic adverse reactions, including heart rate and blood pressure.
Stewart
W C
WC
Department of Ophthalmology, University of South Carolina, Charleston.
Shields
M B
MB
Allen
R C
RC
Lewis
R A
RA
Cohen
J S
JS
Hoskins
H D
HD
Hetherington
J N
JN
Bahr
R L
RL
Noblin
J E
JE
Delehanty
J T
JT
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects; D002354:Carteolol / Q000627:therapeutic use*; D004304:Dosage Forms; D004311:Double-Blind Method; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D013999:Timolol / Q000627:therapeutic use*
D004304:Dosage Forms; D013999:Timolol; D002354:Carteolol