[Assessment of the effect of ibuprofen and other non-steroidal anti-rheumatic drugs in experimental algesimetry].
This paper describes an experimental method for the assessment of analgesic effects of NSAIDs in healthy human volunteers. Pain was induced by repeated controlled pinching of interdigital webs. The painfulness of the stimulus was assessed by the subjects at regular intervals on an electronically controlled visual analog scale. Furthermore, computer supported infrared thermography, laser Doppler flowmetry and photoplethysmography were used to measure the cutaneous vascular reactions. The results of two double-blind cross-over studies are described in which analgesic effects of acetylsalecylic acid, ibuprofen, and dipyrone were significantly demonstrated. In one of the studies it was also shown that ibuprofen reduced the local stimulus-induced vasodilatation. In summary, this algesimetric model seems to be suited to demonstrate the analgesic and perhaps also the antiinflammatory effects of NSAIDs in healthy subjects.
Handwerker
H O
HO
Institut für Physiologie und Biokybernetik, Universität Erlangen.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D009619:Nociceptors / Q000187:drug effects*; D010147:Pain Measurement / Q000295:instrumentation*; D012684:Sensory Thresholds / Q000187:drug effects
D007052:Ibuprofen
Der Wirkungsnachweis von Ibuprofen und anderen nichtsteroidalen Antirheumatika in der experimentellen Algesimetrie.