title: Evaluation of a new bladder tumor marker.
abstract: Two monoclonal antibodies have been developed that bind to a shed bladder tumor-associated antigen. Preliminary data have demonstrated that antigen-positive tumors shed detectable amounts of antigen in the urine while antigen-negative tumors do not. This antigen may be differentially metabolized by normal and malignant urothelial cells. Further characterization of this antigen and its evaluation as a urinary marker for antigen positive bladder cancers is continuing.
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor.
authors.forename: H B
authors.initials: HB
authors.lastname: Grossman
authors.forename: M
authors.initials: M
authors.lastname: Liebert
authors.forename: N
authors.initials: N
authors.lastname: Sakakibara
authors.forename: G A
authors.initials: GA
authors.lastname: Wedemeyer
authors.forename: J A
authors.initials: JA
authors.lastname: Stein
authors.forename: R W
authors.initials: RW
authors.lastname: Washington
mesh_terms: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D006383:Hemadsorption Inhibition Tests; D006801:Humans; D007124:Immunoenzyme Techniques; D008970:Molecular Weight; D011863:Radioimmunoassay; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor