title: Tanning salon exposure suppression of DNA repair capacity and mitogen-induced DNA synthesis.
abstract: Mitogen responsiveness and the capacity to repair genetic damage were measured in lymphocytes collected from young, healthy, adult Caucasians immediately before exposure in commercial tanning salons and again 24 h after exposure. For every individual studied, tanning exposure produced significant inhibition of phytohemagglutinin-induced mitogenesis or of the ability to repair DNA lesions by unscheduled DNA synthesis. The results imply that such exposure could: (1) pose a significant hazard for individuals who are already immunosuppressed (e.g. cancer patients, AIDS patients or carriers of latent HIV) and (2) increase the carcinogenic effects of environmental mutagens.
authors.affiliation: Department of Microbiology, Clemson University, SC 29634.
authors.forename: L L
authors.initials: LL
authors.lastname: Larcom
authors.forename: T E
authors.initials: TE
authors.lastname: Morris
authors.forename: M E
authors.initials: ME
authors.lastname: Smith
mesh_terms: D000328:Adult; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000528:radiation effects*; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000528:radiation effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D010835:Phytohemagglutinins; D004247:DNA