title: Electrophysiologic-structural correlations in chagasic aneurysms causing malignant arrhythmias.
abstract: We studied the structure and ultrastructure of three chagasic aneurysms, the excision of which abolished malignant arrhythmias. Chronic recurrent ventricular tachycardia often occurs in patients with chagasic aneurysms, and ventricular mapping indicates that these arrhythmias originate in regions adjacent to those aneurysms. In our patients, ventricular tachycardia had been refractory to medical treatment. During surgery, epicardial and endocardial mapping showed abnormal potentials. Sutures were placed in the areas of resection, their sizes approximating those of earliest activation so that these sites could be identified. The myocardium showed chronic inflammatory reaction, myocytolysis and fibrosis. The presence of "islets" was common (normal, "early" damaged or "established" necrotic myocytes surrounded by fibrous tissue). The "early" lesions were predominant at the previously identified areas of arrhythmogenic activity. The ultrastructural studies showed hypertrophy of myocytes and partial or complete loss of myofibrils, swelling of mitochondria and disruption of mitochondrial cristae, accumulation of lipofuscin granules, and intracellular oedema. A most striking alteration was the thickening of the basement membranes of myocytes and vascular endothelial and smooth muscle cells. The interlaced fronts of respectively healthy (fast conducting) and "early" damaged (slow conducting) myocytes seen in serial sectioning produced an ideal configuration for reentry circuits. The final proof that the arrhythmias originated in these endocardial regions was their abolition by resection of the aneurysm.
authors.affiliation: Cardiopsis, Hospital Juan A. Fernández, Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Milei
authors.forename: R
authors.initials: R
authors.lastname: Pesce
authors.forename: E
authors.initials: E
authors.lastname: Valero
authors.forename: C
authors.initials: C
authors.lastname: Muratore
authors.forename: R
authors.initials: R
authors.lastname: Beigelman
authors.forename: V J
authors.initials: VJ
authors.lastname: Ferrans
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology; D002598:Chagas Cardiomyopathy / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006322:Heart Aneurysm / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged