title: Exogenous iron overload in perinatal hemochromatosis: a case report.
abstract: We report an infant with fatal neonatal liver disease in whom efforts to correct an associated unremitting anemia resulted in massive exogenous iron overload that was expressed as perinatal hemochromatosis (PH). Levels of iron and copper were elevated in multiple tissues. Echovirus subtype 9, recovered from the urine at age 3 weeks, may have been etiologic in the liver failure. PH is best viewed as a definable phenotype with an undefined genetic and/or environmental basis that emerges only in the context of severe perinatal liver disease. The absence of hemosiderin in splenic and bone marrow reticuloendothelial (RE) cells of our patient suggests an important role for RE cell dysfunction.
authors.affiliation: Division of Pathology, Children's Hospital Medical Center, Cincinnati, Ohio 45229.
authors.forename: K E
authors.initials: KE
authors.lastname: Bove
authors.forename: R
authors.initials: R
authors.lastname: Wong
authors.forename: H
authors.initials: H
authors.lastname: Kagen
authors.forename: W
authors.initials: W
authors.lastname: Balistreri
authors.forename: M W
authors.initials: MW
authors.lastname: Tabor
mesh_terms: D000740:Anemia / Q000151:congenital / Q000628:therapy; D003300:Copper / Q000378:metabolism; D006432:Hemochromatosis / Q000097:blood / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007501:Iron / Q000097:blood* / Q000378:metabolism; D008107:Liver Diseases / Q000151:congenital / Q000628:therapy; D008297:Male; D065227:Transfusion Reaction
chemical_list: D003300:Copper; D007501:Iron