Inhibition of growth of rat hepatoma by local injection of liposomes containing recombinant interleukin-2. Antitumor effect of IL-2 liposome.
Human recombinant interleukin-2 (IL-2) was entrapped in liposome, consisting of egg phosphatidylcholine (PC) and cholesterol. The peri-tumor injections of IL-2 liposome inhibited significantly the growth of solid tumor and prolonged the survival time of rats with solid tumors which were induced by a subcutaneous (s.c.) inoculation of AH-66 cells. Immunohistochemical staining of peritoneal exudate cells and tumor tissues revealed a marked accumulation of activated macrophages in and around the tumor tissues induced by the local injections of IL-2 liposome.
Konno
H
H
Second Department of Surgery, Hamamatsu University School of Medicine, Japan.
Yamashita
A
A
Tadakuma
T
T
Sakaguchi
S
S
D000818:Animals; D005122:Exudates and Transudates / Q000166:cytology; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use*; D008081:Liposomes; D008114:Liver Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
D007376:Interleukin-2; D008081:Liposomes; D011994:Recombinant Proteins