Changes of negative charge on RBC and glomeruli and its relation to the proteinuria of adriamycin nephrosis in rats.
The depth and area-percentage of Alcian blue (AB) staining of glomeruli, the ability of RBC to bind AB and the onset of proteinuria in adriamycin nephrosis in rats were studied. The results showed that the negative charge (NC) on RBC and glomeruli decreased significantly after injection of adriamycin and there was a positive correlation between them (r = 0.77, P less than 0.01). There was a negative correlation between the amount of NC on the RBC and the amount of urinary protein (r = -0.5231, P less than 0.01), and also between the amount of NC on the glomeruli and the amount of urinary protein (r = -0.5140, P less than 0.05).
Chen
Z Y
ZY
Faculty of Pediatrics, Nanjing Medical College.
Jiang
X Y
XY
D000818:Animals; D000838:Anions; D004317:Doxorubicin; D004594:Electrophysiology; D004912:Erythrocytes / Q000378:metabolism / Q000502:physiology*; D005260:Female; D007091:Image Processing, Computer-Assisted; D007211:Indoles; D007678:Kidney Glomerulus / Q000502:physiology*; D009401:Nephrosis / Q000139:chemically induced / Q000378:metabolism*; D009942:Organometallic Compounds; D011507:Proteinuria / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000838:Anions; D007211:Indoles; D009942:Organometallic Compounds; C015445:copper phthalocyanine; D004317:Doxorubicin