title: [Potential antiestrogens of the 1,2-diphenyl-1-pyridyl-but-1-ene type. 2. Biological testing].
abstract: Z-1-(4-hydroxyphenyl)-1-(4-resp. 3-pyridyl)-2-phenyl-but-1-enes Z-1 and Z-2 and their acetates Z-1a and Z-2a are weak estrogens (uterine weight test, immature mouse), which cause a marked tumor growth inhibition on the hormone-dependent MXT mammary carcinoma of the mouse. No or just slight estrogenic side effects determined by uterine weight are detectable in this tumor experiment.
authors.affiliation: Sonderforschungsbereich 234, Institut für Pharmazie, Universität Regensburg.
authors.forename: W
authors.initials: W
authors.lastname: Schwarz
authors.forename: R W
authors.initials: RW
authors.lastname: Hartmann
authors.forename: H
authors.initials: H
authors.lastname: Schönenberger
mesh_terms: D000818:Animals; D004965:Estrogen Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism; D013267:Stilbenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D004965:Estrogen Antagonists; D011960:Receptors, Estrogen; D013267:Stilbenes
vernacular_title: Potentielle Antiöstrogene vom Typ des 1,2-diphenyl-1-pyridyl-but-1-ens. Teil 2: Biologische Prüfung.