[The effect of aminophylline on plasma oxypurines in patients with bronchial asthma or cor pulmonale].
The effect of aminophylline administered intravenously in dose 250 mg on plasma oxypurines (hypoxanthine and xanthine) concentration as well as on plasma adenosine deaminase activity and plasma AMP deaminase activity was studied in 17 patients with bronchial asthma or chronic cor pulmonale. Initial plasma oxypurines concentration was 47.5 +/- 10.4 mumol/l and one hour after aminophylline administration decreased significantly (p less than 0.001) to the value 40.3 +/- 8.8 mumol/l. Plasma adenosine deaminase activity increased significantly from 4.74 +/- 2.3 IU to 6.9 +/- 2.77 IU (p less than 0.01), while plasma AMP deaminase activity did not change. The above results suggest indirectly that intravenous administration of aminophylline decreases serum adenosine concentration in studied patients.
Banaszak
F
F
Zakładu Fizjologii Człowieka Akademii Wychowania Fizycznego w Poznaniu.
Głuszek
J
J
Tykarski
A
A
D000328:Adult; D000628:Aminophylline / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000097:blood / Q000188:drug therapy*; D019820:Xanthine; D014970:Xanthines / Q000097:blood*
D007042:Hypoxanthines; D014970:Xanthines; D019820:Xanthine; D000628:Aminophylline; D019271:Hypoxanthine
Wpływ aminofiliny na stezenie oksypuryn w osoczu krwi chorych na astme oskrzelowa lub zespół płucno-servowy.