title: [Pancreatic penetration of antibiotics].
abstract: Antibiotic therapy is indicated in acute pancreatitis because the most common complication and the mean reason for mortality is a bacterial infection. Concentrations of nine antibiotics from various classes were studied in the pancreatic tissue and pancreatic juice of patients and dogs. The volume of distribution is the most valuable parameter for predicting the potential pancreatic penetration of a substance. As a result of our pharmacokinetic studies mezlocillin and cefotiam, especially ciprofloxacin, have the most antiinfectious potential in treatment of acute pancreatitis. Metronidazole is suitable for combination in cases of pancreatic infections covering anaerobic bacteria.
authors.affiliation: Chirurgische Klinik, Universität Rostock.
authors.forename: K
authors.initials: K
authors.lastname: Koch
authors.forename: B
authors.initials: B
authors.lastname: Drewelow
authors.forename: S
authors.initials: S
authors.lastname: Liebe
authors.forename: R
authors.initials: R
authors.lastname: Reding
authors.forename: A K
authors.initials: AK
authors.lastname: Riethling
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D004285:Dogs; D008826:Microbial Sensitivity Tests; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Die Pankreasgängigkeit von Antibiotica.