title: Survival of XO mouse fetuses: effect of parental origin of the X chromosome or uterine environment?
abstract: Using a recombinant product from the structurally abnormal Y chromosome, Y*, female mice with a single X of either maternal or paternal origin were generated. The two types of females were produced on the same genetic background and differ only in the origin of the X chromosome. Hence it has been possible to assess the effect of parental origin of the X on survival of females with a single X chromosome. A highly significant prenatal loss of females with a single X of paternal origin, but no comparable loss of females with a single X of maternal origin was observed. The reduced viability of females with a paternally derived X could be mediated by the parental origin of the X (i.e. X chromosome imprinting) or alternatively, since the mothers of females with a single paternally derived X have only a single X chromosome, the effect could be mediated by the genotype of the mother (i.e. maternal uterine effect).
authors.affiliation: Winship Cancer Center, Emory University, Atlanta, Georgia 30322.
authors.forename: P A
authors.initials: PA
authors.lastname: Hunt
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D005260:Female; D005298:Fertility / Q000235:genetics; D005313:Fetal Death / Q000235:genetics*; D005821:Genetic Techniques; D005838:Genotype; D008098:Litter Size; D051379:Mice; D008817:Mice, Mutant Strains; D011247:Pregnancy; D012098:Reproduction / Q000235:genetics; D014960:X Chromosome / Q000502:physiology*