Epidermal growth factor enhances short-term potentiation and facilitates induction of long-term potentiation in rat hippocampal slices.
Effects of recombinant human epidermal growth factor (hEGF) on short-term potentiation (STP) of evoked potential were investigated in Schaffer/commissural-CA1 pyramidal cell synapses of rat hippocampal slices. Perfusion of hEGF (6-60 ng/ml) significantly enhanced the STP induced by shorter tetanus (11 impulses at 100 Hz) in a concentration-dependent manner and the effect resulted in generation of long-term potentiation (LTP). The results suggest that hEGF can activate the mechanisms related to induction of LTP.
Abe
K
K
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Xie
F J
FJ
Saito
H
H
D000818:Animals; D004558:Electric Stimulation; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000187:drug effects*; D011712:Pyramidal Tracts / Q000166:cytology / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D013997:Time Factors
D011994:Recombinant Proteins; D004815:Epidermal Growth Factor