Disposition of lypophilized (methylmethacrylate-14C, 2-hydroxyethylmethacrylate, butylacrylate) nanoparticles in rats and their effect on zoxazolamine paralysis time.
The fate of lyophilized (methylmethacrylate-14C, 2-hydroxyethylmethacrylate, butylacrylate) nanoparticles was studied in male Wistar rats after p.o. administration. It was found that at least 4% of the dose of 14C was absorbed from the gastrointestinal tract after a single dose with these nanoparticles. Some radioactivity (less than 0.15% of dose) was found 7 d after administration in lung, spleen and liver. As expected excretion of the label was predominated via the feces. Ten d of p.o. treatment of rats with lyophilized nanoparticles (1 g/kg of body weight) was shown to prolong significantly zoxazolamine paralysis time. This result suggests that lyophilized nanoparticles decreased elimination of zoxazolamine.
Kukan
M
M
Institute of Experimental Pharmacology, Slowak Academy of Sciences, Bratislava.
Koprda
V
V
Bezek
S
S
Kálal
J
J
Labský
J
J
Trnovec
T
T
D000179:Acrylates / Q000493:pharmacokinetics* / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D003692:Delayed-Action Preparations; D005243:Feces / Q000737:chemistry; D005612:Freeze Drying; D007408:Intestinal Absorption; D008297:Male; D008689:Methacrylates / Q000493:pharmacokinetics* / Q000494:pharmacology; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000493:pharmacokinetics* / Q000494:pharmacology; D008863:Microspheres; D010243:Paralysis / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution; D015049:Zoxazolamine
D000179:Acrylates; D003692:Delayed-Action Preparations; D008689:Methacrylates; D008768:Methylmethacrylates; D020366:Methylmethacrylate; C005044:hydroxyethyl methacrylate; C032490:n-butyl acrylate; D015049:Zoxazolamine