Influence of molecular structure on the synergistic action of theophylline or dipyridamole derivatives in the prostaglandin-type inhibition of platelet aggregation.
Approximately 30 new derivatives of theophylline and dipyridamole have been prepared and examined as potentiators of the inhibition of platelet aggregation induced by the prostaglandin analogue BW 245C. Potentiating activity has been found to be sensitive to molecular size and also to the presence of specific groups. Polymeric adducts based on dextran, poly(ethylene glycol) or poly(N-vinyl pyrrolidone), and aliphatic esters with alkyl chain-lengths greater than 7 are inactive in potentiation. Derivatives containing carboxyl groups are also inactive. Potentiation is discussed in terms of platelet membrane penetration and extra- and intra-cellular processes. The latter are invoked to account for the enhanced potentiation shown by dipyridamole and derivatives when aggregation is induced by PAF-acether rather than ADP. One derivative of particular interest is the adduct of theophylline with 1,2,5,6-diisopropylidene-D-glucose, containing a furanose ring. This is a more active potentiator than theophylline itself, possibly owing to its molecular resemblance to cAMP. On conversion to the pyranose form all activity is removed.
Bamford
C H
CH
Institute of Medical and Dental Bioengineering, University of Liverpool, UK.
Middleton
I P
IP
al-Lamee
K G
KG
D000818:Animals; D004176:Dipyridamole / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004357:Drug Synergism; D006827:Hydantoins / Q000494:pharmacology*; D015394:Molecular Structure; D008970:Molecular Weight; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis; D011108:Polymers / Q000138:chemical synthesis; D012756:Sheep; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D006827:Hydantoins; D010975:Platelet Aggregation Inhibitors; D011108:Polymers; D004176:Dipyridamole; C030669:BW 245C; D013806:Theophylline