Chronic hypernatremia due to impaired osmoregulated thirst and vasopressin secretion.
We report the case of a young man who became adipsic following a subarachnoid hemorrhage and subsequently had two episodes of life-threatening hypernatremia. Investigations demonstrated that he had defective osmoregulated thirst and AVP release, but normal AVP responses to hypotension and nausea. There is also evidence that he had intact baroregulated thirst. We discuss the results of our investigations in the context of current models of hypothalamic-neurohypophysial function.
Pearce
S H
SH
Endocrine Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Argent
N B
NB
Baylis
P H
PH
D000328:Adult; D001058:Apomorphine / Q000494:pharmacology; D001127:Arginine Vasopressin / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D002908:Chronic Disease; D004326:Drinking; D004639:Emetics / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D008297:Male; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D012964:Sodium / Q000097:blood*; D013894:Thirst / Q000187:drug effects / Q000502:physiology*; D014294:Trimethaphan / Q000494:pharmacology; D014882:Water-Electrolyte Balance
D004639:Emetics; D012462:Saline Solution, Hypertonic; D001127:Arginine Vasopressin; D014294:Trimethaphan; D012964:Sodium; D005947:Glucose; D001058:Apomorphine