title: A case of pemphigus vulgaris in a six-year-old girl.
abstract: A case of pemphigus vulgaris in a six-year-old Japanese girl is presented. She first developed vesicles and ulcerations in oral and laryngeal mucous membranes, showing a hoarse voice and fits of coughing with excessive slavering. She had skin blisters six months later. Biopsy of the skin lesion demonstrated the intraepidermal blister in a suprabasal location. Direct immunofluorescence (IF) of the skin lesion revealed deposits of IgG and C3. Indirect IF showed serum anti-ICS antibody titer at 1:640. She was diagnosed as having pemphigus vulgaris. Treatment with oral prednisolone (1 mg/kg) proved effective. This is the first case of infantile pemphigus vulgaris in Japan.
authors.affiliation: Department of Dermatology, Osaka University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shoda
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D010392:Pemphigus / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis