Pancreatic enhancement after low-dose infusion of Mn-DPDP.
Enhancement of the pancreas was demonstrated after low-dose (10 mumol/kg) infusion of a new contrast agent for magnetic resonance (MR) imaging, manganese dipyridoxal-diphosphate (Mn-DPDP). To the authors' knowledge, this has not been described previously. The enhancement reached a maximum of 98% +/- 13% (standard deviation) during a long period (greater than 6 hours). Mn-DPDP seems to have potential as a selective contrast agent in MR imaging of the pancreas.
Gehl
H B
HB
Department of Diagnostic Radiology, Technical University Aachen, Germany.
Vorwerk
D
D
Klose
K C
KC
Günther
R W
RW
D003287:Contrast Media / Q000008:administration & dosage; D004492:Edetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D007089:Image Enhancement; D007262:Infusions, Intravenous; D008099:Liver / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008345:Manganese / Q000008:administration & dosage; D010179:Pancreas / Q000033:anatomy & histology*; D011732:Pyridoxal Phosphate / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013997:Time Factors
D003287:Contrast Media; D008345:Manganese; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid