title: Continuous infusion of high doses of atropine in the management of organophosphorus compound poisoning.
abstract: Forty five cases of organophosphorus poisoning were studied to evaluate the results of continuous infusion of high doses of atropine as against the conventional intermittent therapy. A statistically significant reduction in mortality (23.5% to 8.8%; p less than 0.05) was evident in this study as compared to previous years. Pseudocholinesterase levels below 10% of normal were associated with a poor prognosis and increased mortality.
authors.affiliation: Department of Medicine, St Martha's Hospital, Bangalore.
authors.forename: J S
authors.initials: JS
authors.lastname: Ram
authors.forename: S S
authors.initials: SS
authors.lastname: Kumar
authors.forename: A
authors.initials: A
authors.lastname: Jayarajan
authors.forename: G
authors.initials: G
authors.lastname: Kuppuswamy
mesh_terms: D000293:Adolescent; D000328:Adult; D001285:Atropine / Q000008:administration & dosage*; D002219:Carbamates; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D009943:Organophosphorus Compounds; D011041:Poisoning / Q000188:drug therapy*; D013406:Suicide, Attempted / Q000517:prevention & control
chemical_list: D002219:Carbamates; D007306:Insecticides; D009943:Organophosphorus Compounds; D001285:Atropine