Halofantrine hydrochloride--efficacy and safety in children with acute malaria.
Thirty two children with symptomatic malaria due to P. vivax and P. Falciparum infections were treated with three doses of Halofantrine hydrochloride 8 mg/kg body weight every 6 hours. Mean fever clearance was 30 hours (range 24-48 hours). No significant clinical or biochemical side effects were observed. Symptoms cleared rapidly. Halofantrine hydrochloride was found to be highly effective and appeared to have no side effects in children with acute malaria infections.
Khan
M A
MA
Children Hospital, Pakistan Institute of Medical Sciences, Islamabad.
Rehman
G N
GN
Qazi
S A
SA
D000208:Acute Disease; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D010616:Phenanthrenes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010963:Plasmodium falciparum; D010966:Plasmodium vivax; D012449:Safety
D000962:Antimalarials; D010616:Phenanthrenes; C023768:halofantrine