The hypercholesterolemic effect of dietary coconut fat versus corn oil in hypo- or hyperresponsive rabbits is not exerted through influencing cholesterol absorption.
In two inbred strains of rabbits with high or low response of plasma cholesterol to dietary saturated versus polyunsaturated fatty acids, the efficiency of intestinal cholesterol absorption was measured. The feeding of a cholesterol-free purified diet containing saturated fatty acids in the form of coconut fat, when compared with a diet containing corn oil as polyunsaturated fatty acids, did not influence the efficiency of cholesterol absorption in the two rabbit strains. Irrespective of the dietary fat source, the hyperresponsive rabbits absorbed cholesterol more efficiently. It is concluded that the hypercholesterolemic effect of dietary coconut fat versus corn oil is not exerted by influencing cholesterol absorption.
Meijer
G W
GW
Department of Laboratory Animal Science, State University, Utrecht, The Netherlands.
Lemmens
A G
AG
Versluis
A
A
Van Zutphen
L F
LF
Beynen
A C
AC
D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000032:analysis; D000074263:Coconut Oil; D003059:Cocos; D003314:Corn Oil; D004041:Dietary Fats; D005247:Feeding Behavior; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000503:physiopathology*; D007408:Intestinal Absorption; D008099:Liver / Q000378:metabolism; D008297:Male; D010938:Plant Oils; D011817:Rabbits; D012855:Sitosterols / Q000032:analysis; D013045:Species Specificity
D002791:Cholesterol, Dietary; D004041:Dietary Fats; D010938:Plant Oils; D012855:Sitosterols; C025473:gamma-sitosterol; D003314:Corn Oil; D002784:Cholesterol; D000074263:Coconut Oil