title: Ultrastructural examination of experimentally induced premalignant lesions.
abstract: Lesions induced in hamster cheek pouch using dimethylbenz(alpha)anthracene were studied by transmission electron microscopy and compared with normal tissue. Features regarded as suggestive of progression towards malignancy were: increased numbers of membrane-bound vesicles in basal cells, gaps in the lamina densa associated with widening of the lamina lucida and an irregular epithelial-connective tissue junction, the presence of cerebriform cells and frequent close association of 2 or more intra-epithelial cells (lymphocytes, cerebriform cells, Langerhans cells).
authors.affiliation: Department of Oral Medicine and Oral Surgery, University of Otago, Dunedin, New Zealand.
authors.forename: J W
authors.initials: JW
authors.lastname: Ferguson
authors.forename: M D
authors.initials: MD
authors.lastname: McMillan
authors.forename: A C
authors.initials: AC
authors.lastname: Smillie
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000648:ultrastructure; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D002610:Cheek; D006224:Cricetinae; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D006965:Hyperplasia; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D009061:Mouth Mucosa / Q000098:blood supply / Q000648:ultrastructure*; D009062:Mouth Neoplasms / Q000098:blood supply / Q000648:ultrastructure*; D015388:Organelles / Q000187:drug effects / Q000648:ultrastructure; D011230:Precancerous Conditions / Q000098:blood supply / Q000648:ultrastructure*
chemical_list: D015127:9,10-Dimethyl-1,2-benzanthracene