Efficacy of misoprostol and ranitidine in the prevention of duodenal ulcer relapse and its correlation with endogenous gastric prostanoid synthesis.
We determined endogenous gastric prostaglandin synthesis and its correlation with the prevention of duodenal ulcer relapse by misoprostol and ranitidine. Sixty-one patients with recent endoscopically healed duodenal ulcer were randomly allocated in a double-blind fashion for one year of treatment with misoprostol 400 micrograms nocte, ranitidine 150 mg nocte or placebo. Patients were followed every two months. Endoscopy was repeated at six and 12 months or beforehand, if relapse was suspected. Antral and fundic biopsies, 3-4 from each region, were obtained at each endoscopy for determination of prostaglandin synthesis. During the one year of treatment, 11 out of the 12 placebo treated patients flared up, as opposed to 10 out of 25 and four out of 24 misoprostol and ranitidine treated patients, respectively. The difference between all treatment groups was significant (P less than 0.0001). In all subjects who flared up, pretrial endogenous antral and fundic prostaglandin E2 synthesis were not different from their respective synthesis in those who did not relapse.
Goldin
E
E
Department of Gastroenterology, Hadassah University Hospital, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
Karmeli
F
F
Rachmilewitz
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D015232:Dinoprostone / Q000096:biosynthesis; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000378:metabolism / Q000517:prevention & control*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016595:Misoprostol; D009924:Organ Culture Techniques; D011453:Prostaglandins / Q000096:biosynthesis*; D011863:Radioimmunoassay; D011899:Ranitidine / Q000627:therapeutic use*; D012008:Recurrence; D013270:Stomach / Q000187:drug effects
D000897:Anti-Ulcer Agents; D011453:Prostaglandins; D016595:Misoprostol; D011899:Ranitidine; D000527:Alprostadil; D015232:Dinoprostone