title: Differential sugar absorption for the assessment of canine intestinal permeability: the cellobiose/mannitol test in gluten-sensitive enteropathy of Irish setters.
abstract: Intestinal permeability was assessed in Irish setters with gluten-sensitive enteropathy by oral administration of an isotonic solution of cellobiose and mannitol, and measurement of their urinary excretion ratio. The cellobiose/mannitol ratio was increased in affected Irish setters fed a wheat-containing diet compared both with littermates reared on a cereal-free diet, with no evidence of jejunal damage, and clinically healthy Irish setters. The ratio fell following six weeks on a gluten-free diet to be comparable with control values, and subsequently increased after six weeks gluten challenge. The results indicate that the cellobiose/mannitol test may be useful for the detection of mucosal damage and for monitoring the response to therapy.
authors.affiliation: Department of Veterinary Pathology, University of Liverpool.
authors.forename: E J
authors.initials: EJ
authors.lastname: Hall
authors.forename: R M
authors.initials: RM
authors.lastname: Batt
mesh_terms: D000818:Animals; D001947:Breeding; D002446:Celiac Disease / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D002475:Cellobiose / Q000493:pharmacokinetics* / Q000652:urine; D004032:Diet; D004283:Dog Diseases / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D004285:Dogs; D005983:Glutens / Q000008:administration & dosage; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D008353:Mannitol / Q000493:pharmacokinetics* / Q000652:urine; D010539:Permeability
chemical_list: D002475:Cellobiose; D008353:Mannitol; D005983:Glutens