Tumor cell motility.
Tumor cell motility is required for invasion and metastasis. The locomotory machinery of the cell includes cell projections called pseudopodia which are regulated by a complicated linkage between cell surface receptors or sensors and the internal cytoskeleton. Recently a new class of motility stimulating cytokines have been identified. These cytokines can function as autocrine motility factors and require a pertussis toxin sensitive G protein pathway to transduce a random motile response.
Liotta
L A
LA
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Stracke
M L
ML
Aznavoorian
S A
SA
Beckner
M E
ME
Schiffmann
E
E
D014408:Biomarkers, Tumor / Q000502:physiology; D002465:Cell Movement; D002633:Chemotaxis; D005109:Extracellular Matrix / Q000502:physiology; D005956:Glucose-6-Phosphate Isomerase / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D007335:Insulin-Like Growth Factor II / Q000502:physiology; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D011554:Pseudopodia / Q000502:physiology; D015398:Signal Transduction
D014408:Biomarkers, Tumor; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D005956:Glucose-6-Phosphate Isomerase