title: Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.
abstract: We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL-10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth when combined with IL-3 or IL-4. Moreover, IL-4 plus IL-10 supported the proliferation of mast cells as well as IL-3, suggesting that these two factors may provide a pathway for their development independent of IL-3. However, optimal mast cell growth was stimulated by the combination of IL-10, IL-4, and IL-3. This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses.
authors.affiliation: Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304.
authors.forename: L
authors.initials: L
authors.lastname: Thompson-Snipes
authors.forename: V
authors.initials: V
authors.lastname: Dhar
authors.forename: M W
authors.initials: MW
authors.lastname: Bond
authors.forename: T R
authors.initials: TR
authors.lastname: Mosmann
authors.forename: K W
authors.initials: KW
authors.lastname: Moore
authors.forename: D M
authors.initials: DM
authors.lastname: Rennick
mesh_terms: D000818:Animals; D002455:Cell Division; D002460:Cell Line; D016753:Interleukin-10; D007377:Interleukin-3 / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D007378:Interleukins / Q000502:physiology*; D008407:Mast Cells / Q000166:cytology* / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins
chemical_list: D007377:Interleukin-3; D007378:Interleukins; D011994:Recombinant Proteins; D016753:Interleukin-10; D015847:Interleukin-4