[Reexpression of the embryonic form of NCAM in the rat hippocampus after status epilepticus induced by neurotoxic agent].
The neural cell adhesion molecule (NCAM) is known to take part in the cohesion of cellular interactions through a homophilic binding mechanism. During development, NCAM shifts from an embryonic polysialic acid-rich form to a poorer adult one. This conversion reflects a loss of plasticity to the benefit of more stability. We have shown here an inverse process, namely the reexpression of the embryonic form of NCAM in adult rats following a status epilepticus induced through systemic administration of kainic acid.
Le Gal La Salle
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Laboratoire de Physiologie nerveuse, C.N.R.S., Gif-sur-Yvette.
Valin
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D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000737:chemistry*; D006624:Hippocampus / Q000737:chemistry* / Q000473:pathology; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013226:Status Epilepticus / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology
D015816:Cell Adhesion Molecules, Neuronal; D007608:Kainic Acid
Réexpression de la forme embryonnaire de NCAM dans l'hippocampe de rat après état de mal épileptique induit par un neurotoxique.