title: The actions of NSAIDs.
abstract: The ability of aspirin and related drugs to inhibit prostaglandin biosynthesis accounts for many effects of NSAIDs but does not completely explain their efficacy against inflammation. An additional mechanism may be disruption of the intracellular signal pathways responsible for activation of inflammatory cells--notably, neutrophils.
authors.affiliation: Division of Rheumatology, New York University School of Medicine.
authors.forename: G
authors.initials: G
authors.lastname: Weissmann
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects / Q000276:immunology; D002462:Cell Membrane / Q000187:drug effects / Q000276:immunology; D004347:Drug Interactions; D019204:GTP-Binding Proteins / Q000187:drug effects / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008565:Membrane Proteins / Q000187:drug effects / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000096:biosynthesis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008565:Membrane Proteins; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D019204:GTP-Binding Proteins