title: [Successful treatment of metastatic and refractory osteosarcoma by ifosfamide, carboplatin and vindesine: case report].
abstract: A 13-year-old boy with unresectable pulmonary metastatic osteosarcoma, which was refractory to high dose methotrexate, adriamycin, cisplatin and combination of bleomycin, cyclophosphamide and actinomycin D, was treated by aggressive chemotherapy including the combination of ifosfamide (1 g/m2 x day 1-4), Carboplatin (100 mg/m2 x day 1-4) and Vindesine (4 mg/m2 x day 1). After 5 courses of the treatment, pulmonary metastasis regressed, respiratory symptoms resolved completely, and in this regimen no severe toxicity was observed. Thoracotomy for pulmonary metastatic osteosarcoma is an accepted treatment, but treatment for patients with unresectable disease has not been established. It is suggested that this regimen is relatively safe and very effective for refractory and unresectable osteosarcoma.
authors.affiliation: Dept. of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: N
authors.initials: N
authors.lastname: Kiyokawa
authors.forename: K
authors.initials: K
authors.lastname: Takada
authors.forename: K
authors.initials: K
authors.lastname: Kyo
authors.forename: K
authors.initials: K
authors.lastname: Ishimoto
authors.forename: K
authors.initials: K
authors.lastname: Yabuta
authors.forename: T
authors.initials: T
authors.lastname: Mizuno
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000473:pathology*; D016190:Carboplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D014751:Vindesine / Q000008:administration & dosage
chemical_list: D016190:Carboplatin; D014751:Vindesine; D007069:Ifosfamide