title: Hepatitis C virus infection in patients with chronic liver diseases.
abstract: Antibodies against hepatitis C (HCV) in 512 patients were measured by an enzyme immunoassay (Ortho-HCV ELISA). The frequency of anti-HCV was 80%, 86%, 85% in nonB (NB) chronic hepatitis (CH), cirrhosis (LC), hepatocellular carcinoma (HCC), respectively; 70%, 90% in alcoholic (AL) LC, HCC; 15%, 33%, 58% in hepatitis B (HB) CH, LC, HCC, respectively. Anti-HCV positive cirrhotics had a shorter survival time and earlier development of HCC than anti-HCV negative cirrhotics. The findings suggest that HCV is a major cause of NB chronic liver diseases and may play a pathogenetic role in AL and HB liver diseases.
authors.affiliation: Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: T
authors.initials: T
authors.lastname: Tsujii
authors.forename: H
authors.initials: H
authors.lastname: Fukui
authors.forename: J
authors.initials: J
authors.lastname: Yamao
authors.forename: N
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: N
authors.initials: N
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Kyo
authors.forename: A
authors.initials: A
authors.lastname: Takaya
authors.forename: H
authors.initials: H
authors.lastname: Tsujii
authors.forename: H
authors.initials: H
authors.lastname: Nakano
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000453:epidemiology*; D006801:Humans; D008107:Liver Diseases / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies
chemical_list: D006508:Hepatitis Antibodies