Cytogenetic studies of gastric adenocarcinoma.
Cytogenetic analyses were performed on a short-term culture of a primary tumor and an established cell line of gastric adenocarcinoma (SC-M1). The former case was near-diploid, and the latter was near-triploid. No common numerical and structural change or breakpoint was found in these cells. Review of the 13 cases of gastric carcinomas so far reported showed that only trisomies 8 and 9 were consistent findings. The Y chromosome, although lost in all the near-triploid cases, was preserved in all of the near-diploid cases. No consistent structural abnormality and breakpoint were identified in this and other studies.
Tzeng
C C
CC
Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China.
Meng
C L
CL
Jin
L
L
Hsieh
H F
HF
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D002460:Cell Line; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D004171:Diploidy; D006801:Humans; D007621:Karyotyping; D008297:Male; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D014314:Trisomy; D014407:Tumor Cells, Cultured