Continuous infusion of high doses of atropine in the management of organophosphorus compound poisoning.
Forty five cases of organophosphorus poisoning were studied to evaluate the results of continuous infusion of high doses of atropine as against the conventional intermittent therapy. A statistically significant reduction in mortality (23.5% to 8.8%; p less than 0.05) was evident in this study as compared to previous years. Pseudocholinesterase levels below 10% of normal were associated with a poor prognosis and increased mortality.
Ram
J S
JS
Department of Medicine, St Martha's Hospital, Bangalore.
Kumar
S S
SS
Jayarajan
A
A
Kuppuswamy
G
G
D000293:Adolescent; D000328:Adult; D001285:Atropine / Q000008:administration & dosage*; D002219:Carbamates; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D009943:Organophosphorus Compounds; D011041:Poisoning / Q000188:drug therapy*; D013406:Suicide, Attempted / Q000517:prevention & control
D002219:Carbamates; D007306:Insecticides; D009943:Organophosphorus Compounds; D001285:Atropine