title: A computer program for the estimation of kinetic parameters of membrane currents based on the Gauss-Newton method.
abstract: A computer program based on the Gauss-Newton method was developed for the Hodgkin-Huxley estimation of kinetic parameters of membrane currents recorded in voltage-clamp experiments. Fast potassium current of land snail neurons was estimated, and found to be in agreement with literature reports.
authors.affiliation: National Center for Scientific Research, Neuroscience Center, Havana, Cuba.
authors.forename: R
authors.initials: R
authors.lastname: Grave de Peralta
authors.forename: J L
authors.initials: JL
authors.lastname: Hernández
authors.forename: M
authors.initials: M
authors.lastname: Castellanos
authors.forename: A
authors.initials: A
authors.lastname: Garateix
mesh_terms: D000465:Algorithms; D000818:Animals; D007700:Kinetics; D008432:Mathematical Computing; D008564:Membrane Potentials / Q000502:physiology; D015221:Potassium Channels / Q000378:metabolism*; D012908:Snails; D012984:Software
chemical_list: D015221:Potassium Channels