title: The effect of bromhexine on albumin excretion in insulin dependent diabetes.
abstract: The effect of the mucolytic agent bromhexine, 72 mg daily for one month, on albumin excretion in insulin dependent diabetes was investigated in a double-blind, randomised, cross-over, placebo-controlled study. Nine patients with normal albumin excretion [overnight albumin excretion rate 3.2 (2.1-8.8) micrograms/min.; mean (range)], six with microalbuminuria [36 (22-95) micrograms/min.] and six with macroalbuminuria [321 (201-1215) micrograms/min.] participated. Albumin excretion was similar after treatment with bromhexine and placebo in all 3 groups [normoalbuminurics 3.6 (1.7-13.5) versus 3.3 (1.9-13.2) micrograms/min.; microalbuminurics 40 (20-128) versus 37 (20-103); macroalbuminurics 396 (247-2160) versus 443 (292-2592)]. Excretion of beta 2-microglobulin and creatinine clearance were identical at the end of each treatment. Blood glucose control and blood pressure remained constant throughout the study in the 3 groups. We conclude that bromhexine 72 mg daily for 1 month had no effect on albumin excretion in IDDM patients with normal and pathological albuminuria.
authors.affiliation: Department of Medecine, University of Newcastle upon Tyne, U.K.
authors.forename: S M
authors.initials: SM
authors.lastname: Marshall
authors.forename: P A
authors.initials: PA
authors.lastname: Shearing
authors.forename: J H
authors.initials: JH
authors.lastname: Shelley
authors.forename: K G
authors.initials: KG
authors.lastname: Alberti
mesh_terms: D000328:Adult; D000419:Albuminuria; D001964:Bromhexine / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000503:physiopathology / Q000652:urine*; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D004311:Double-Blind Method; D006801:Humans; D007677:Kidney Function Tests; D008875:Middle Aged
chemical_list: D003404:Creatinine; D001964:Bromhexine