RecA protein in the SOS response: milestones and mysteries.
The role of RecA protein in the SOS response of Escherichia coli is traced from the isolation of the first recA mutant to our current understanding of the scope and regulation of this DNA damage-inducible system. In addition, possible RecA protein activities that may be essential in the expression of several SOS phenotypes (stable DNA replication, DNA replication recovery, SOS mutagenesis and RecA association with the cell membrane) are discussed.
Witkin
E M
EM
Waksman Institute of Microbiology, Rutgers State University of New Jersey, Piscataway 08854.
D004260:DNA Repair; D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics*; D016296:Mutagenesis; D011938:Rec A Recombinases / Q000235:genetics / Q000378:metabolism*; D013014:SOS Response, Genetics / Q000502:physiology*
D011938:Rec A Recombinases