Separation and identification of N4-(guanosin-7-yl)-4-aminoquinoline 1-oxide, a novel nucleic acid adduct of carcinogen 4-nitroquinoline 1-oxide.
A novel nucleic acid adduct of the carcinogen 4-nitroquinoline 1-oxide, N4-(guanosin-7-yl)-4-aminoquinoline 1-oxide, was separated and identified after RNA was treated with activated 4-hydroxyaminoquinoline 1-oxide. This is the first report of a 7-arylaminated guanine adduct produced by arylaminating carcinogens.
Kohda
K
K
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Kawazoe
Y
Y
Minoura
Y
Y
Tada
M
M
D015112:4-Nitroquinoline-1-oxide / Q000378:metabolism*; D000634:Aminoquinolines / Q000737:chemistry / Q000302:isolation & purification*; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D006151:Guanosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification
D000634:Aminoquinolines; D006151:Guanosine; C070128:N(4)-(guanosin-7-yl)-4-aminoquinoline 1-oxide; D015112:4-Nitroquinoline-1-oxide; D004247:DNA