title: [In vitro activity of beta-lactam antibiotics in combination with sulbactam against enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter. Results of a multicenter study].
abstract: The in vitro antimicrobial activity of ticarcillin (TICAR), mezlocillin (MEZLO), piperacillin (PIPER), cefoperazone (CPZ), cefotaxime (CTX) and ceftazidime (CAZ), alone and in combination with 8 micrograms/ml of sulbactam (SULB), was studied by agar dilution against TICAR resistant strains isolated in 8 hospitals over a period of 3 months in 1989 (747 enterobacteria, 110 Ps. aeruginosa and 48 Acinetobacter sp.). SULB did not modify the activity of beta-lactam antibiotics against Ps. aeruginosa. The 6 beta-lactam antibiotics SULB combinations were only active for 27% of Acinetobacter SULB sensitive. SULB restored the activity of: MEZLO, PIPER, CPZ in Enterobacteria producing a penicillinase; PIPER, CTX and CAZ in Enterobacteria producing a broad-spectrum beta-lactamase; MEZLO, PIPER, CTX and CAZ in M. morganii producing a derepressed cephalosporinase.
authors.affiliation: Laboratoire de Bactériologie, Centre Hospitalier Universitaire, Dijon.
authors.forename: A
authors.initials: A
authors.lastname: Kazmierczak
authors.forename: E
authors.initials: E
authors.lastname: Siebor
authors.forename: J F
authors.initials: JF
authors.lastname: Acar
authors.forename: F
authors.initials: F
authors.lastname: Denis
authors.forename: H
authors.initials: H
authors.lastname: Drugeon
authors.forename: J
authors.initials: J
authors.lastname: Fleurette
authors.forename: J
authors.initials: J
authors.lastname: Sirot
authors.forename: C J
authors.initials: CJ
authors.lastname: Soussy
authors.forename: A
authors.initials: A
authors.lastname: Thabaut
mesh_terms: D000150:Acinetobacter / Q000187:drug effects; D002438:Cefoperazone / Q000494:pharmacology; D002439:Cefotaxime / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008802:Mezlocillin / Q000494:pharmacology*; D010878:Piperacillin / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013407:Sulbactam / Q000494:pharmacology*; D013982:Ticarcillin / Q000494:pharmacology*
chemical_list: D002438:Cefoperazone; D002442:Ceftazidime; D013982:Ticarcillin; D002439:Cefotaxime; D008802:Mezlocillin; D013407:Sulbactam; D010878:Piperacillin
vernacular_title: Activité des bêtalactamines en association avec le sulbactam chez les entérobactéries Pseudomonas aeruginosa et Acinetobacter. Résultats d'une étude multicentrique.