title: [The rapid magnetic resonance tomography measurement of the contrast medium dilution kinetics (gadolinium-DTPA) in a circulatory phantom].
abstract: We studied first-pass MRI contrast dilution to compute flow and volume of distribution in a realistic flow phantom. Pulsatile flow was provided by a one-chamber artificial heart. Physiological stroke volume, rate, pressure, and flow were adjustable. An elastic tube with dimensions similar to that of the human aorta was imaged at a rate of 2.4 Hz. After contrast injection, an initial increase in signal intensity was followed by a decrease. Signal-intensity time plots demonstrated slightly skewed curves as expected from dispersion theory. After calibration at different gadolinium-DTPA concentrations, signal intensities were converted into true gadolinium concentrations, and flow was calculated from the concentration-time curves. Flow was varied between 2.5 and 10.0 l/min and a significant correlation was found between the MRI estimate and true flow. Volume of distribution between injection and detection site was reliably estimated. This study demonstrates rapid 2-D imaging of a paramagnetic contrast bolus in a realistic flow phantom. Reliable estimates of flow and volume are obtained.
authors.affiliation: Strahlenklinik und Poliklinik, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin.
authors.forename: J C
authors.initials: JC
authors.lastname: Böck
authors.forename: B
authors.initials: B
authors.lastname: Sander
authors.forename: J
authors.initials: J
authors.lastname: Frank
authors.forename: W
authors.initials: W
authors.lastname: Schörner
mesh_terms: D003287:Contrast Media / Q000493:pharmacokinetics*; D005682:Gadolinium / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA; D006801:Humans; D007201:Indicator Dilution Techniques; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008955:Models, Cardiovascular; D008961:Models, Structural; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000493:pharmacokinetics*; D011673:Pulsatile Flow
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA
vernacular_title: Schnelle magnetresonanztomographische Messung von Kontrastmittelverdünnungskinetiken (Gadolinium-DTPA) in einem Kreislaufphantom.