Selective attenuation of cocaine-induced stereotyped behaviour by oxytocin: putative role of basal forebrain target sites.
The effects of oxytocin (OXT), arginine- and lysine-vasopressin (AVP and LVP) and an OXT-receptor antagonist on cocaine-induced sniffing behaviour were investigated in rats. OXT, but not AVP or LVP injected subcutaneously (s.c.) attenuated cocaine-induced sniffing. The effect of OXT (s.c.) was inhibited by an OXT-receptor antagonist administered intracerebroventricularly (i.c.v.). I.c.v. administration of different doses of OXT in nanogram quantities caused a dose-dependent attenuation of cocaine-induced sniffing. Local cerebral microinjection of OXT into the accumbens nucleus and olfactory tubercle but not into the olfactory nucleus, central amygdaloid nucleus or caudate nucleus, inhibited the cocaine-induced sniffing behaviour. These results demonstrate that OXT selectively attenuates the cocaine-induced stereotyped behaviour through basal forebrain target sites.
Sarnyai
Z
Z
Institute of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Babarczy
E
E
Kriván
M
M
Szabó
G
G
Kovács
G L
GL
Barth
T
T
Telegdy
G
G
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D003042:Cocaine / Q000037:antagonists & inhibitors*; D004027:Diencephalon / Q000187:drug effects*; D007276:Injections, Intraventricular; D008236:Lypressin / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D010121:Oxytocin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*; D013687:Telencephalon / Q000187:drug effects*
D001127:Arginine Vasopressin; D010121:Oxytocin; D008236:Lypressin; D003042:Cocaine