Inhibition of rabbit erythroid 15-lipoxygenase and sheep vesicular gland prostaglandin H synthase by gallic esters.
Gallic acid esters possessing a varying chain length of their alcohol moiety were tested for their inhibitory potencies on 15-lipoxygenase from rabbit reticulocytes and prostaglandin H synthase from sheep vesicular glands. Octyl gallate and decyl gallate proved to be the most powerful inhibitors of both enzymes showing concentrations of half-inhibition of about 0.25 mumol/l for the reticulocyte lipoxygenase and of about 25 mumol/l for the prostaglandin H synthase.
Luther
H
H
Institute of Biochemistry, Medical School (Charité), Humboldt-University, Berlin.
Jordanov
D
D
Ludwig
P
P
Schewe
T
T
D000818:Animals; D016861:Cyclooxygenase Inhibitors; D005088:Exocrine Glands / Q000201:enzymology*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors; D011463:Prostaglandins H / Q000096:biosynthesis*; D011817:Rabbits; D012156:Reticulocytes / Q000201:enzymology*; D012756:Sheep
D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D011463:Prostaglandins H; D005707:Gallic Acid