title: Coronary artery pseudo-occlusion associated with the use of an active hemoperfusion system during PTCA.
abstract: We describe the phenomenon of coronary artery "pseudo-occlusion," which may occur when active hemoperfusion devices are utilized during percutaneous transluminal coronary angioplasty (PTCA). In such cases, contrast injected via the guiding catheter fails to opacify the coronary artery distal to the tip of the dilating catheter, thereby giving the angiographic appearance of coronary occlusion. When active hemoperfusion is terminated, contrast opacifies the vessel in a normal fashion. The cause of this observation is likely multifactorial and includes obstruction to flow by the dilating catheter, high distal pressure delivered by the dilating catheter during hemoperfusion competing with the flow of contrast injected via the guiding catheter, and wash-out of contrast at the tip of the dilating catheter by non-contrast containing blood being pumped through the system. This phenomenon must be recognized if potentially deleterious repeat dilatations are to be avoided.
authors.affiliation: Johns Hopkins Hospital, Division of Cardiology, Baltimore, MD 21205.
authors.forename: H P
authors.initials: HP
authors.lastname: Grill
authors.forename: B A
authors.initials: BA
authors.lastname: Dowger
authors.forename: J A
authors.initials: JA
authors.lastname: Brinker
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D003287:Contrast Media / Q000008:administration & dosage; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003951:Diagnostic Errors; D006083:Graft Occlusion, Vascular / Q000628:therapy; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media