Mitogenic properties of major extracellular proteins.
The major plasma and extracellular matrix proteins are multifunctional molecules. Some, such as fibrinogen or C3, have one domain that binds adhesion receptors and another that specifically binds and activates a separate, mitogenic receptor. In this review, Jean-Pierre Lévesque, Antoinette Hatzfeld and Jacques Hatzfeld describe adhesion and mitogenic receptors that bind to distinct domains of the same extracellular matrix protein and discuss the possibility of common ancestral genes for cell adhesion molecules, extracellular matrix proteins, integrins, immunoglobulins, growth factors and their receptors.
Lévesque
J P
JP
Laboratoire de Biologie Cellulaire et Moléculaire des Facteurs de Croissance (Centre National de la Recherche Scientifique), Höpital Paul-Brousse, Villejuif, France.
Hatzfeld
A
A
Hatzfeld
J
J
D003176:Complement C3 / Q000276:immunology; D016326:Extracellular Matrix Proteins / Q000276:immunology*; D005340:Fibrinogen / Q000276:immunology; D005353:Fibronectins / Q000276:immunology; D006801:Humans; D008934:Mitogens / Q000276:immunology
D003176:Complement C3; D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D008934:Mitogens; D005340:Fibrinogen