title: Effect of a single dose of TCDD on the level of histamine in discrete nuclei in rat brain.
abstract: Histaminergic neurones may be involved in the regulation of feed intake. Since TCDD causes anorexia in rats, histamine concentrations were measured in several hypothalamic nuclei involved in feeding regulation. Histamine concentrations were not changed in medial or lateral accumbens, suprachiasmatic, paraventricular, arcuate, ventromedial, dorsomedial or perifornical nuclei, or in lateral hypothalamic area, cortex, or pineal gland. There was, however, an increase in histamine concentration in median eminence 25 h after the administration of TCDD.
authors.affiliation: Department of Pharmacology and Toxicology, University of Kuopio, Finland.
authors.forename: J T
authors.initials: JT
authors.lastname: Tuomisto
authors.forename: M
authors.initials: M
authors.lastname: Unkila
authors.forename: R
authors.initials: R
authors.lastname: Pohjanvirta
authors.forename: M
authors.initials: M
authors.lastname: Koulu
authors.forename: L
authors.initials: L
authors.lastname: Tuomisto
mesh_terms: D000818:Animals; D004435:Eating / Q000502:physiology*; D006632:Histamine / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008473:Median Eminence / Q000378:metabolism; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D051381:Rats
chemical_list: D000072317:Polychlorinated Dibenzodioxins; D006632:Histamine