Numerical chromosome abnormalities associated with early clinical stages of gynecologic tumors.
Cytogenetic data are presented for 12 ovarian, three endometrial, and one fallopian tube tumors. In 15 of these, primary tumors were analyzed and in one ascites was studied. All specimens were obtained at the time of diagnostic surgery. Trisomy for chromosome 7 was detected in three ovarian and one endometrial tumors. In one case, trisomy 7 was the sole cytogenetic abnormality detected. Three of the four patients with trisomy 7 had early stages of adenocarcinoma. The data suggest that numerical chromosome abnormalities may be common in borderline and in less aggressive gynecologic tumors.
Tharapel
S A
SA
National Cytogenetics Reference Laboratory, VA Medical Center, Memphis, Tennessee.
Qumsiyeh
M B
MB
Photopulos
G
G
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D016889:Endometrial Neoplasms / Q000235:genetics / Q000473:pathology; D005185:Fallopian Tube Neoplasms / Q000235:genetics / Q000473:pathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology