title: [State of the hypophyseal-gonadal system in patients with hypertension during long-term treatment with nadolol and anaprilin].
abstract: The changes in hormone levels of the hypophyseal-gonadal system were studied during 6-month monotherapy with nadolol, 40-160 mg/day, or anaprilin, 80-240 mg/day, in 40 males with Stage II hypertensive disease. Serum levels of prolactin, luteinizing, follicle-stimulating, and testicular hormones, and estradiol were measured by radioimmunoassay at the end of control placebo, 2-week, 2- and 6-month therapy. The negative changes revealed in the hypophyseal-gonadal system, as manifested by elevated prolactin and estradiol levels, diminished testicular hormone concentration, indicate that the levels of these hormones should be monitored in a long-term antihypertensive therapy with beta-adrenoblockers.
authors.forename: N B
authors.initials: NB
authors.lastname: Gumbatov
authors.forename: R N
authors.initials: RN
authors.lastname: Mamedova
authors.forename: I I
authors.initials: II
authors.lastname: Mustafaev
authors.forename: F Z
authors.initials: FZ
authors.lastname: Kasumova
authors.forename: Kh M
authors.initials: KhM
authors.lastname: Umudov
authors.forename: A K
authors.initials: AK
authors.lastname: Orudzheva
mesh_terms: D000328:Adult; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009248:Nadolol / Q000008:administration & dosage* / Q000494:pharmacology; D010902:Pituitary Gland / Q000187:drug effects*; D011388:Prolactin / Q000097:blood; D011433:Propranolol / Q000008:administration & dosage* / Q000494:pharmacology; D011863:Radioimmunoassay; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood; D013997:Time Factors
chemical_list: D013739:Testosterone; D009248:Nadolol; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011433:Propranolol
vernacular_title: Sostoianie gipofizarno-gonadnoĭ sistemy u bol'nykh gipertonicheskoĭ bolezn'iu pri dlitel'nom lechenii nadololom i anaprilinom.