title: Effects of hypoxia on fetal rat brain metabolism studied in utero by 31P-NMR spectroscopy.
abstract: An animal model of perinatal asphyxia, in which near-term fetal rats are subjected to-short periods of hypoxia, has been investigated by 31P-NMR spectroscopy. Changes in the high-energy phosphates and intracellular pH of the fetal rat brain were measured in utero following ligation of the placental blood vessels, and during reperfusion after a 20-min period of occlusion. The hypoxia-induced changes observed in the fetal brain were substantially slower than in the adult, and were completely reversible after 20 min of hypoxia.
authors.affiliation: Department of Physiological Sciences, University of Manchester, U.K.
authors.forename: C T
authors.initials: CT
authors.lastname: O'Shaughnessy
authors.forename: D J
authors.initials: DJ
authors.lastname: Lythgoe
authors.forename: S P
authors.initials: SP
authors.lastname: Butcher
authors.forename: L
authors.initials: L
authors.lastname: Kendall
authors.forename: B
authors.initials: B
authors.lastname: Wood
authors.forename: M C
authors.initials: MC
authors.lastname: Steward
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate