Pharmacological relaxation of the urethra in male cats: a study of the effects of phenoxybenzamine, diazepam, nifedipine and xylazine.
Urethral pressure profiles (UPPs) were recorded in ten adult healthy male cats before and after administration of either phenoxybenzamine, diazepam, nifedipine or xylazine. A significant decrease (p less than 0.05) in urethral pressure at the level of the prostate was observed following treatment with all drugs. Xylazine produced a significant decrease in urethral pressure 4 to 7 cm from the tip of the penis in healthy male cats. None of the drugs used decreased urethral pressure in the zones of pure striated muscle or pure smooth muscle in these cats, making current recommendations for pharmacological management of urethral spasm suspect. Further studies are necessary to evaluate clinical cases of urethral spasm and to study the effects of these drugs on the urethral pressure of cats suffering from this spasm.
Mawby
D I
DI
Department of Veterinary Internal Medicine, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon.
Meric
S M
SM
Crichlow
E C
EC
Papich
M G
MG
D000284:Administration, Oral; D000818:Animals; D002415:Cats / Q000502:physiology*; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009132:Muscles / Q000187:drug effects / Q000502:physiology; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D010643:Phenoxybenzamine / Q000008:administration & dosage / Q000494:pharmacology*; D011312:Pressure; D011897:Random Allocation; D012149:Restraint, Physical; D014521:Urethra / Q000187:drug effects* / Q000502:physiology; D014546:Urinary Catheterization / Q000662:veterinary; D014991:Xylazine / Q000008:administration & dosage / Q000494:pharmacology*
D010643:Phenoxybenzamine; D014991:Xylazine; D009543:Nifedipine; D003975:Diazepam