title: Effects of a fish oil diet on pigs' cardiopulmonary response to bacteremia.
abstract: Since an omega 3 fatty acid (FA) diet may have beneficial effects in inflammatory processes, we tested the hypothesis that the physiologic response to sepsis could be modified by altering the eicosanoid precursor pool via an omega 3 FA diet. Two groups (n = 8) of pigs were prefed for 8 days either an omega 3 FA or an omega 6 FA diet (Weaner Pig Feed with either menhaden or corn oil to produce a eucaloric feed with 15% fat) and then injected with live Escherichia coli. The omega 3 FA diet increased the concentration of eicosapentainoic acid (EPA, 20:5 omega 3) in plasma lipids, and increased the ratio of EPA to arachidonic acid (AA, 20:4 omega 6) in platelets from 1:20 to 1:1 over the 8 days. Following the injection of bacteria, there was a fall in PaO2 and blood pressure that was attenuated (p less than 0.05) by the omega 3 FA diet. The omega 3 FA diet, compared to the omega 6 FA diet, also attenuated the rise in thromboxane B2 (3.0 +/- 1.1 vs 12.9 +/- 5.7 ng/mL) and 6 keto-PGF1 alpha (0.8 +/- 0.5 vs 1.7 +/- 1.1 ng/mL) associated with bacteremia. We conclude that dietary omega 3 FA attenuated the physiologic response to sepsis, possibly by modifying arachidonic acid metabolism.
authors.affiliation: Critical Care Service, Mayo Clinic, Rochester, MN 55905.
authors.forename: M J
authors.initials: MJ
authors.lastname: Murray
authors.forename: B A
authors.initials: BA
authors.lastname: Svingen
authors.forename: R T
authors.initials: RT
authors.lastname: Holman
authors.forename: T L
authors.initials: TL
authors.lastname: Yaksh
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism; D001794:Blood Pressure; D002319:Cardiovascular System / Q000503:physiopathology*; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D015118:Eicosapentaenoic Acid / Q000097:blood; D004927:Escherichia coli Infections / Q000150:complications / Q000503:physiopathology*; D005395:Fish Oils / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008168:Lung / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010100:Oxygen / Q000097:blood; D011654:Pulmonary Edema / Q000209:etiology; D018805:Sepsis / Q000150:complications / Q000178:diet therapy / Q000503:physiopathology*; D013552:Swine; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D001095:Arachidonic Acids; D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D008055:Lipids; D016718:Arachidonic Acid; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015118:Eicosapentaenoic Acid; D010100:Oxygen; D009638:Norepinephrine