[The granulocyte-macrophage colony stimulating factor and the radiation protective effect of yeast mannan].
The effect of mannan polysaccharide on the haemopoiesis recovery in irradiated mice has been investigated. Mannan has been shown to exert both the protective and the stimulatory effect: it accelerates restoration of femur bone marrow cellularity and nucleate cell number in the peripheral blood and causes a larger initial yield and subsequent more rapid postirradiation dynamics of pluripotent haemopoietic stem cells and precursor cells of granulocytes and macrophages.
Chernysheva
N M
NM
Kaplan
V P
VP
Konopliannikov
A G
AG
Babaian
T L
TL
Lepekhina
L A
LA
D000818:Animals; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology*; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D008351:Mannans / Q000627:therapeutic use*; D051379:Mice; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013268:Stimulation, Chemical
D008351:Mannans; D011837:Radiation-Protective Agents; D016178:Granulocyte-Macrophage Colony-Stimulating Factor
Stimuliruiushchiĭ granulotsitarno-makrofagal'nyĭ rostok i radiozashchitnyĭ éffekty drozhzhevogo mannana.