Organization of the human HLA-class-II region.
A detailed map of the class-II region of the human MHC has been established by pulsed-field-gel-electrophoresis (PFGE) mapping and cloning in yeast-artificial-chromosome (YAC) vectors. The map revealed CpG islands, which are frequently associated with genes, in the gaps between the known HLA-class-II genes. Using cosmid walking and chromosome jumping, we have cloned 3 of these islands and have identified 5 novel genes, named RINGI-5. This brief report summarizes our present knowledge of these genes.
Hanson
I
I
Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Holborn, London, UK.
Ragoussis
J
J
Trowsdale
J
J
D002874:Chromosome Mapping; D016386:Chromosome Walking; D003001:Cloning, Molecular; D003360:Cosmids; D015342:DNA Probes; D005802:Genes, MHC Class II; D005822:Genetic Vectors; D006801:Humans; D008285:Major Histocompatibility Complex; D012441:Saccharomyces cerevisiae / Q000235:genetics
D015342:DNA Probes