Intestinal permeability in patients with psoriasis.
A possible relationship between intestinal structure and function in the pathogenesis of psoriasis has recently brought about considerable interest. The purpose of this study was to evaluate the intestinal permeability in psoriatic patients by comparing it with healthy controls. 15 psoriatic patients and 15 healthy volunteers entered the study. Intestinal permeability was evaluated using the 51Cr-labeled EDTA absorption test. The 24-h urine excretion of 51Cr-EDTA from psoriatic patients was 2.46 +/- 0.81%. These results differed significantly from controls (1.95 +/- 0.36%; P less than 0.05). The difference in intestinal permeability between psoriatic patients and controls could be due to alterations in the small intestinal epithelium of psoriatics.
Humbert
P
P
Department of Dermatology, Hôpital St Jacques, Besançon, France.
Bidet
A
A
Treffel
P
P
Drobacheff
C
C
Agache
P
P
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000652:urine; D002463:Cell Membrane Permeability / Q000502:physiology*; D002860:Chromium Radioisotopes; D002940:Circadian Rhythm / Q000502:physiology; D004492:Edetic Acid / Q000493:pharmacokinetics / Q000652:urine; D004847:Epithelial Cells; D004848:Epithelium / Q000473:pathology / Q000502:physiology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000652:urine; D007408:Intestinal Absorption / Q000502:physiology*; D007422:Intestines / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000473:pathology / Q000503:physiopathology*
D002860:Chromium Radioisotopes; D007070:Immunoglobulin A; D004492:Edetic Acid; D000469:Alkaline Phosphatase