title: Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis.
abstract: The expression pattern and DNA sequence of a newly identified gene, CNC (cap'n'collar), suggest a role for this gene in cephalic patterning during Drosophila embryogenesis. In situ hybridization reveals transcripts localized to the mandibular segment and the hypopharyngeal and labral primordia first detectable in late blastoderm stages. Sequence analysis of cDNA clones from the CNC locus shows the CNC gene product to be related to transcription factors of the leucine zipper (bZIP) class. Based on its protein sequence, we propose that CNC is a subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis.
authors.affiliation: Barnard College, Dept. of Biological Sciences, New York, NY 10027.
authors.forename: J
authors.initials: J
authors.lastname: Mohler
authors.forename: K
authors.initials: K
authors.lastname: Vani
authors.forename: S
authors.initials: S
authors.lastname: Leung
authors.forename: A
authors.initials: A
authors.lastname: Epstein
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016386:Chromosome Walking; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006257:Head / Q000196:embryology*; D016350:Leucine Zippers / Q000235:genetics* / Q000502:physiology; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000235:genetics
chemical_list: D014157:Transcription Factors