Pure FSH for ovulation induction in patients with polycystic ovary syndrome and resistant to clomiphene citrate therapy.
Twenty-nine infertile women with polycystic ovary disease which was resistant to therapy with clomiphene citrate underwent a combined treatment for follicle recruitment consisting of pure FSH during the first days of the cycle and HMG during the last days of the follicular phase. Sixty cycles were stimulated of which 83% were ovulatory. Eighteen pregnancies were achieved (36% of cycles, 62% of patients). The multiple pregnancy rate was 39%. Twelve cycles (20%) showed the ovarian hyperstimulation syndrome (OHS) although seven of these resulted in full term deliveries. There were no miscarriages among the patients studied.
Neyro
J L
JL
Department of Obstetrics and Gynaecology, Universidad del Pais Vasco, Hospital de Cruces, Baracaldo, Spain.
Barrenetxea
G
G
Montoya
F
F
Rodriguez-Escudero
F J
FJ
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D004351:Drug Resistance / Q000502:physiology; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006728:Hormones / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000503:physiopathology*; D011247:Pregnancy; D011256:Pregnancy Outcome
D006728:Hormones; D002996:Clomiphene; D004958:Estradiol; D005640:Follicle Stimulating Hormone