title: Effects of amphetamine on T-cell immune response in mice.
abstract: Mice chronically injected with amphetamine (0.4 mg/kg/day) showed a reduction in thymus and spleen cellularity, and in peripheral T lymphocyte population. The blastogenic response of spleen lymphoid cells was assessed and amphetamine was found to inhibit T-cell proliferation. Amphetamine also reduced the capacity of mice to the development and passive transfer of immunity to Listeria monocytogenes.
authors.affiliation: Department of Pharmacology, School of Medicine, University of Santiago de Compostela, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Freire-Garabal
authors.forename: J L
authors.initials: JL
authors.lastname: Balboa
authors.forename: M J
authors.initials: MJ
authors.lastname: Núñez
authors.forename: M T
authors.initials: MT
authors.lastname: Castaño
authors.forename: J B
authors.initials: JB
authors.lastname: Llovo
authors.forename: J C
authors.initials: JC
authors.lastname: Fernández-Rial
authors.forename: A
authors.initials: A
authors.lastname: Belmonte
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D005260:Female; D016219:Immunotherapy, Adoptive; D007958:Leukocyte Count / Q000187:drug effects; D008089:Listeria monocytogenes / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
chemical_list: D000661:Amphetamine