Light- and electron-microscopical study of a case of gold salt-induced hepatotoxicity.
A 56-yr-old woman with long-standing rheumatoid arthritis exhibited jaundice, pruritus and abdominal discomfort after 8 yr of periodic gold sodium thiomalate injections amounting to a cumulative dose in excess of 2.5 gm. Histopathological examination of the liver biopsy specimen showed submassive loss of parenchyma, collapse of reticulin and mixed cellular inflammatory infiltrates. Macrophages contained dark granules, which displayed the characteristics of aurosomes when examined by transmission electron microscopy and electron microprobe analysis. It is likely that hepatocellular injury occurred when the lysosomal storage capacity for gold was exceeded.
Fleischner
G M
GM
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
Morecki
R
R
Hanaichi
T
T
Hayashi
H
H
Quintana
N
N
Sternlieb
I
I
D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004577:Electron Probe Microanalysis; D005260:Female; D006052:Gold Sodium Thiomalate / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008247:Lysosomes / Q000648:ultrastructure; D008264:Macrophages / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D013997:Time Factors
D006052:Gold Sodium Thiomalate