Immunoprophylaxis against Theileria annulata with protein from plasma membrane of infected lymphoblasts.
Cross-bred (Bos taurus male x Bos indicus female) calves were protected against the homologous sporozoite-induced challenge of Theileria annulata when immunised with protein from the plasma membrane of macroschizont-infected lymphoblasts of allogeneic origin. However, such protection was parasite-strain specific with the plasma membrane originating from lymphoblasts infected and transformed by the same isolate of T. annulata sporozoites. No protection ensued when the infected lymphoblasts and sporozoites were from immunologically different isolates of T. annulata. There was enhanced proliferation of cells and evidence for lymphokine, originating from antigen-sensitised lymphocytes, demonstrable as macrophage migration inhibition factor in peripheral blood lymphocytes of the calves immunised by plasma membrane protein and challenged by sporozoites of homologous origin.
Chaudhri
S S
SS
Regional Station, Haryana Agricultural University, Karnal, India.
Subramanian
G
G
D000818:Animals; D016782:Apicomplexa / Q000276:immunology*; D001798:Blood Proteins / Q000276:immunology*; D002417:Cattle; D002462:Cell Membrane / Q000276:immunology; D007114:Immunization / Q000662:veterinary*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000469:parasitology; D008297:Male; D008565:Membrane Proteins / Q000276:immunology; D012397:Rosette Formation; D013801:Theileriasis / Q000517:prevention & control*
D001798:Blood Proteins; D008565:Membrane Proteins