title: The effect of maternal anaemia and iron deficiency on the ratio of fetal weight to placental weight.
abstract: OBJECTIVE
  To examine the maternal influences which determine large placental weight and a high ratio of placental weight to birthweight. These are known predictors of adult blood pressure.
  
  
  METHODS
  Retrospective analysis of routine obstetric and haematology department records for a large cohort of pregnant women.
  
  
  METHODS
  John Radcliffe Hospital, Oxford.
  
  
  METHODS
  8684 pregnant women who were delivered between January 1987 and January 1989 and whose records could be linked to the results of two or more pregnancy blood counts.
  
  
  METHODS
  Placental weight and the ratio of placental weight to birthweight.
  
  
  RESULTS
  Large placental weight was associated with a low maternal haemoglobin and a fall in maternal mean cell volume during pregnancy. The highest ratio of placental weight to birthweight occurred in the most anaemic women with the largest falls in mean cell volume. Large placental weight and a high ratio of placental weight to birthweight were also independently associated with a high maternal body mass index. Maternal smoking reduced placental weight, but increased the ratio of placental weight to birthweight.
  
  
  CONCLUSIONS
  Anaemia and iron deficiency during pregnancy are associated with large placental weight and a high ratio of placental weight to birthweight. This points to maternal nutritional deficiency as a cause for discordance between placental and fetal growth. This may have important implications for the prevention of adult hypertension, which appears to have its origin in fetal life.
authors.affiliation: MRC Environmental Epidemiology Unit (Southampton University), Southampton General Hospital.
authors.forename: K M
authors.initials: KM
authors.lastname: Godfrey
authors.forename: C W
authors.initials: CW
authors.lastname: Redman
authors.forename: D J
authors.initials: DJ
authors.lastname: Barker
authors.forename: C
authors.initials: C
authors.lastname: Osmond
mesh_terms: D000740:Anemia / Q000097:blood / Q000150:complications* / Q000473:pathology; D001724:Birth Weight; D015992:Body Mass Index; D015331:Cohort Studies; D004909:Erythrocyte Indices / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D000090463:Iron Deficiencies; D009929:Organ Size; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000473:pathology*; D012044:Regression Analysis; D012907:Smoking / Q000009:adverse effects