[The effect of the vasoconstrictor glycylpressin on the bioavailability of mitomycin C].
During an intra-arterial chemotherapy of patients with liver metastases the plasma concentration-time curves of Mitomycin C (1) after occlusion of the common hepatic artery by the vasoconstricting agent Glycylpressin (2) were investigated. Vasoconstriction by 2 leads to significantly (p less than 0.01) lower blood levels of 1 in contrast to bolus injection of 1 without 2 under identical dosage regimens. This reduction of systemic availability of about 50% leads to a corresponding higher availability for the tumor region.
Czejka
M
M
Institut für Pharmazeutische Chemie, Universität Wien.
Jäger
W
W
Schüller
J
J
D000368:Aged; D001682:Biological Availability; D004347:Drug Interactions; D006801:Humans; D008236:Lypressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000493:pharmacokinetics*; D000077585:Terlipressin; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D008937:Mitomycins; D014662:Vasoconstrictor Agents; D008236:Lypressin; D016685:Mitomycin; D000077585:Terlipressin
Einfluss des Vasokonstriktors Glycylpressin auf die Verfügbarkeit von Mitomycin C.