Spectrophotometric determination of cimetidine in the presence of its acid-induced degradation products.
Cimetidine has been determined in the presence of its acid-induced degradation products using a second derivative (D2-) spectrophotometric method (method I) or a colorimetric method (method II). The former is based on D2-value measurement at 216 nm, whilst the latter depends on charge-transfer complexation with dichlorophenol-indophenol. The two methods are proved to be stability indicating, since plots of log C% versus time were linear. The application to cimetidine determination in tablets and ampoules gave good results.
Bedair
M M
MM
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
Elsayed
M A
MA
Korany
M A
MA
Fahmy
O T
OT
D002927:Cimetidine / Q000032:analysis* / Q000737:chemistry; D003124:Colorimetry / Q000379:methods; D006851:Hydrochloric Acid; D013053:Spectrophotometry / Q000379:methods; D013607:Tablets
D013607:Tablets; D002927:Cimetidine; D006851:Hydrochloric Acid