[Cytoplasmic receptors of steroid hormones and clinico-morphological characteristics of skin melanoma].
Receptors of estrogens (ER), progesterone (PR), glucocorticoids (GR) and androgens (AR) were assayed in samples obtained from 142 patients with malignant melanoma. GR were observed most often (57% of cases), the percentage being significantly lower for ER (25%) and PR (18%) and extremely low for AR (4%). The occurrence of GR was significantly higher in metastasis to lymph nodes (69%) and soft tissue (67%) as compared to primary tumor (39%). It was higher in acro-lentiginous melanoma (83%) than in superficially extending (30%) or nodular one (33%). GR occurrence rose with the increase in level of invasion (from 30% for level III to 71% for level V) and tumor thickness. In application of adjuvant chemotherapy, patients with GR--negative tumors tended to survive better than those with GR--positive tumors whereas in the chemotherapy-naive group, GR--positive tumors carried better prognosis.
Gershteĭn
E S
ES
Taĭlakov
B B
BB
Smirnova
K D
KD
Kuz'mina
Z V
ZV
Parshikhova
S M
SM
Demidov
L V
LV
D000328:Adult; D000368:Aged; D003593:Cytoplasm / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000737:chemistry* / Q000188:drug therapy / Q000401:mortality; D008875:Middle Aged; D011379:Prognosis; D011944:Receptors, Androgen / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011965:Receptors, Glucocorticoid / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*; D012878:Skin Neoplasms / Q000737:chemistry* / Q000188:drug therapy / Q000401:mortality
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D011980:Receptors, Progesterone; D011987:Receptors, Steroid
Tsitoplazmaticheskie retseptory steroidnykh gormonov i kliniko-morfologicheskie osobennosti melanomy kozhy.