Can acid secretion be predicted in the duodenal ulcer patient by interpretation of mucosal biopsies?
At gastroscopy 4 biopsies were taken from the oxyntic mucosa in 51 patients with duodenal ulcer. The patients underwent an acid stimulating test by injecting 6 microgram 5-gastrin/kg bodyweight. The parietal cell density in the mucosa of the biopsies was determined by cell counting in a standardized lattice. The method was fully acceptable compared with morphometric analysis of the parietal cell density per volume, and had a low intra- and inter-observer variation. Parietal cell density showed a significantly positive correlation with peak acid output (PAO) in patients with PAO less than or equal to 25 meqH+/h, whereas a correlation not could be demonstrated in patients with PAO greater than 25 meqH+/h. The lack of correlation in patients with high acid secretion reduces the value of the parietal cell counting method in predicting acid secretion in patients with duodenal ulcer disease.
Beck
H
H
Department of Surgery I, Kommunehospitalet, Copenhagen, Denmark.
D000328:Adult; D000368:Aged; D001706:Biopsy; D004381:Duodenal Ulcer / Q000473:pathology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005773:Gastroscopy; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000378:metabolism* / Q000473:pathology*