Hydrochlorothiazide inhibits parathormone-stimulated increase in plasma tartrate-resistant acid phosphatase in mice.
The inhibitory effect of hydrochlorothiazide (HTZ) on parathormone-induced bone changes in mice was studied with the aid of the analysis of plasma calcium and tartrate-resistant acid phosphatase. We have found that HTZ alone had no effect on plasma tartrate-resistant acid phosphatase (Tr-ACP), phosphate, and creatinine concentration. Parathormone (PTH) administration increased plasma Tr-ACP from 15.00 +/- 1.50 to 20.62 +/- 2.35 U/liter in intact mice. The increase of plasma Tr-ACP in HTZ-treated mice after PTH administration was not significant. The plasma calcium was affected in a way similar to Tr-ACP. HTZ reduced the sensitivity of bone to resorbing effects of PTH, using Tr-ACP as a useful biomarker of bone resorption.
Broulik
P D
PD
3rd Department of Internal Medicine, Charles University, Faculty of Medicine, Prague, Czechoslovakia.
Pacovský
V
V
D000135:Acid Phosphatase / Q000097:blood*; D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010281:Parathyroid Hormone / Q000494:pharmacology*; D013644:Tartrates / Q000494:pharmacology
D010281:Parathyroid Hormone; D013644:Tartrates; D006852:Hydrochlorothiazide; D003404:Creatinine; D000135:Acid Phosphatase; D002118:Calcium