title: Developmental changes in the organization of the nuclear lamina in mouse liver.
abstract: We have compared the organization of the nuclear lamina in adult and fetal mouse liver. Western blot analysis of the expression of lamins with specific antibodies indicates that lamin B is expressed throughout liver development, unlike lamins A and C which are absent in fetal liver. Using [125I]lamin in blot binding assays, we have observed that lamin B binds to at least three membrane proteins (96, 54 and 34 kDa) and to lamins A and C in adult nuclear envelopes, but only to the 54 and 34 kDa proteins and lamin B itself in fetal nuclear envelopes, where lamin B appears to be hyperphosphorylated.
authors.affiliation: Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: S
authors.initials: S
authors.lastname: Pandey
authors.forename: V K
authors.initials: VK
authors.lastname: Parnaik
mesh_terms: D000818:Animals; D015153:Blotting, Western; D004591:Electrophoresis, Polyacrylamide Gel; D005333:Fetus; D005347:Fibroblasts; D005455:Fluorescent Antibody Technique; D034921:Lamin Type B; D034882:Lamins; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009685:Nuclear Envelope / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*
chemical_list: D034921:Lamin Type B; D034882:Lamins; D009687:Nuclear Proteins