Action of actinomycin D on glycosidase levels in the small intestine of hamsters.
Actinomycin D affects a number of functions of the epithelial cells of the small intestine. Maltase, saccharase and lactase levels in the small intestine of hamsters treated with various dosages of actinomycin D over various periods of time, differed from those observed in control animals: administration of 0.25 micrograms/g body weight, gave rise to a statistically significant increase in the maltase and saccharase levels measured after 4 h and a statistically significant reduction in the lactase levels measured after 8 h; administration of 1.5 micrograms/g body weight reduced the activity of all three enzymes at all times post-administration, the decrease being statistically significant for maltase after 2 and 8 h.
Díaz Regueira
S M
SM
Departamento de Biología Celular y Molecular, Universidad de la Corunña, Spain.
Lamas
M A
MA
Fernández Otero
M P
MP
D000818:Animals; D006224:Cricetinae; D003609:Dactinomycin / Q000008:administration & dosage / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006026:Glycoside Hydrolases / Q000187:drug effects* / Q000378:metabolism; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology*; D043322:Lactase; D008297:Male; D008647:Mesocricetus; D013393:Sucrase / Q000187:drug effects; D000520:alpha-Glucosidases / Q000187:drug effects; D001616:beta-Galactosidase / Q000187:drug effects
D003609:Dactinomycin; D006026:Glycoside Hydrolases; D043322:Lactase; D000520:alpha-Glucosidases; D001616:beta-Galactosidase; D013393:Sucrase