Effect of hyperbaric oxygenation on macrophage function in mice.
Hyperbaric oxygenation (HBO) has an immunosuppressive effect. The possible mechanisms of this immunosuppressive effect were assessed by determining the production of interleukin-1 (IL-1), interleukin-6 (IL-6), and prostaglandin E2 (PGE2), as well as phagocytosis by splenic macrophages from HBO-treated mice. Although HBO treatment did not have any significant effect on IL-6 production and phagocytotic activity, a marked decrease in IL-1 production and a significant decrease in PGE2 production were observed. These results suggest that the reduction of IL-1 production may play an important role in the immunosuppressive effect of HBO.
Inamoto
Y
Y
First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan.
Okuno
F
F
Saito
K
K
Tanaka
Y
Y
Watanabe
K
K
Morimoto
I
I
Yamashita
U
U
Eto
S
S
D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D006931:Hyperbaric Oxygenation; D007375:Interleukin-1 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D007958:Leukocyte Count; D008264:Macrophages / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H; D010101:Oxygen Consumption; D010587:Phagocytosis / Q000502:physiology; D013154:Spleen / Q000166:cytology
D007375:Interleukin-1; D015850:Interleukin-6; D015232:Dinoprostone