The mouse gene retinal degeneration (rd) may reduce the number of neurons present in the adult hippocampal dentate gyrus.
C57BL/6J and C57BL/6J-rd le Gus-sh mice, congenics at the rd locus, were compared with respect to number of granule cells and presumed pyramidal basket cells in the hippocampal dentate gyrus. Number of both types of neurons were less in rd/rd mice than in +/-/+/- mice. The rd gene may be responsible.
Wimer
R E
RE
Division of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010.
Wimer
C C
CC
Alameddine
L
L
Cohen
A J
AJ
D000818:Animals; D002452:Cell Count; D005838:Genotype; D006624:Hippocampus / Q000166:cytology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000502:physiology*; D012162:Retinal Degeneration / Q000235:genetics*