title: The impact of extracorporeal membrane support in the treatment of congenital diaphragmatic hernia.
abstract: Neonates with congenital diaphragmatic hernia (CDH) treated by immediate surgical intervention and conventional ventilatory support have an overall poor survival. The potential of extracorporeal membrane oxygenation (ECMO) therapy to improve survival of infants with CDH remains controversial. Comparison was made in a single institution's pre-ECMO and post-ECMO survival statistics to establish efficacy of extracorporeal support for persistent pulmonary hypertension (PPH). This study was accomplished by stratifying patients by an oxygen index (OI). Sixty-eight patients were treated for CDH from 1977 to 1986 without ECMO. Fifty-eight patients underwent repair of CDH within the first 24 hours of life. Data could be retrieved for calculation of the OI in 46 patients. Nineteen patients developed an OI of 40 or greater; one survived (5%). Three of 27 patients with an OI less than 40 died (OIs = 34, 38, and 38). Thirty-one patients were treated from 1987 to 1989 and none were excluded from ECMO based on a minimum PO2. Fifteen had an OI less than 40 (range, 1 to 38), were treated conventionally, and 13 survived (87%). Sixteen patients had an OI greater than 40 and 13 qualified for ECMO. Nine of 13 survived (69%). Comparing pre-ECMO and post-ECMO survival for infants with an OI of 40 or greater (5% v 69%), there is a significant improvement in survival when ECMO is used (P less than .001). ECMO support offers a strong adjunct in management of neonates with CDH who develop PPH.
authors.affiliation: Division of Pediatric Surgery, Children's Hospital of Los Angeles, CA 90027.
authors.forename: J B
authors.initials: JB
authors.lastname: Atkinson
authors.forename: E G
authors.initials: EG
authors.lastname: Ford
authors.forename: B
authors.initials: B
authors.lastname: Humphries
authors.forename: H
authors.initials: H
authors.lastname: Kitagawa
authors.forename: C
authors.initials: C
authors.lastname: Lew
authors.forename: M
authors.initials: M
authors.lastname: Garg
authors.forename: K
authors.initials: K
authors.lastname: Bui
mesh_terms: D015199:Extracorporeal Membrane Oxygenation; D006548:Hernia, Diaphragmatic / Q000401:mortality / Q000601:surgery*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal; D007430:Intraoperative Care; D010100:Oxygen / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D010100:Oxygen