title: Platelet aggregation induced by uncommon serotypes of Streptococcus sanguis isolated from patients with Behçet's disease.
abstract: Uncommon serotypes were tested for their ability to induce aggregation in platelet-rich plasma. Both uncommon and common serotypes induced platelet aggregation in rabbit platelet-rich plasma, but serotonin release was higher with the uncommon serotypes. Aggregation at ATP release varied between uncommon and common serotypes. With human platelet-rich plasma, only uncommon serotypes showed aggregation. Differences in serotype selectivity and the rate of aggregation were noted among platelet donors. About half of the patients with Behçet's disease and 30% of health controls showed platelet aggregation. Plasma from non-responder patients with Behçet's disease inhibited aggregation of healthy responder platelets within 20 min. Thus selective binding of uncommon serotypes of Strep. sanguis to platelets might cause the vasculitis in Behçet's disease.
authors.affiliation: Department of Preventive Dentistry, School of Dentistry, Higashi Nippon Gakuen University, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Isogai
authors.forename: H
authors.initials: H
authors.lastname: Isogai
authors.forename: K
authors.initials: K
authors.lastname: Yokota
authors.forename: S
authors.initials: S
authors.lastname: Hayashi
authors.forename: N
authors.initials: N
authors.lastname: Fujii
authors.forename: K
authors.initials: K
authors.lastname: Oguma
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Sasamoto
authors.forename: S
authors.initials: S
authors.lastname: Kotake
authors.forename: S
authors.initials: S
authors.lastname: Ohno
mesh_terms: D000255:Adenosine Triphosphate / Q000493:pharmacokinetics; D000818:Animals; D001528:Behcet Syndrome / Q000382:microbiology*; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000382:microbiology; D010974:Platelet Aggregation / Q000502:physiology*; D011817:Rabbits; D012701:Serotonin / Q000493:pharmacokinetics; D012703:Serotyping; D013298:Streptococcus sanguis / Q000145:classification / Q000302:isolation & purification / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors
chemical_list: D012701:Serotonin; D000255:Adenosine Triphosphate