title: Reversal of unconsciousness by use of naloxone in a profoundly mentally handicapped epileptic.
abstract: The reversal of a state of impaired consciousness in a known epileptic following a period of prolonged post-ictal unconsciousness (with flexor response to nociceptive stimuli) was achieved by use of 0.4 mg naloxone intravenously. This decision was based on the similarity of the individuals clinical presentation to that seen in cases of opiate overdose. The implications of this dramatic clinical intervention are discussed.
authors.affiliation: Royal Edinburgh Hospital, Scotland.
authors.forename: M
authors.initials: M
authors.lastname: Turner
authors.forename: M
authors.initials: M
authors.lastname: Stewart
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects; D002547:Cerebral Palsy / Q000150:complications*; D004723:Endorphins / Q000378:metabolism; D004830:Epilepsy, Tonic-Clonic / Q000150:complications*; D006801:Humans; D008607:Intellectual Disability / Q000150:complications*; D008297:Male; D009270:Naloxone / Q000008:administration & dosage*; D009460:Neurologic Examination; D014474:Unconsciousness / Q000188:drug therapy*
chemical_list: D004723:Endorphins; D009270:Naloxone