title: The effect of swine leukocyte antigen haplotype on birth and weaning weights in miniature pigs and the role of statistical analysis in this estimation.
abstract: Miniature pigs of seven swine leukocyte antigen (SLA) genotypes were examined for birth and weaning weights to determine the influence of major histocompatibility (MHC) and background genes on these traits. Effects of different statistical analyses on the magnitude of these associations also were examined. Data on 154 piglets from 32 litters were analyzed by least squares using a linear model that included effects of SLA, litter, and sex of piglet. In these miniature pigs, SLA genotype had little influence on birth and weaning weight; litter, which includes effects of background genes, had a significant effect on both birth weight (P less than or equal to .0001) and weaning (P less than or equal to .005) weight. When litter effects were not accounted for, SLA haplotype appeared to influence both birth (P less than or equal to .001) and weaning (P less than or equal to .10) weights. Use of simple group means, as opposed to least squares means, for comparisons of genotypes yielded misleading results. Simple means indicated that piglets with the aa genotype were heavier (P less than or equal to .01) at birth than those with the cd genotype; in contrast, least squares means showed that cd piglets were slightly heavier at birth (P less than or equal to .10). Heterosis was not observed for birth or weaning weights among piglets of various genotypes, nor did one vs two copies of any haplotype influence these traits.
authors.affiliation: Dept. of Vet. Microbiol. and Immunol., Ontario Veterinary College, University of Guelph, Ontario, Canada.
authors.forename: B A
authors.initials: BA
authors.lastname: Mallard
authors.forename: B W
authors.initials: BW
authors.lastname: Kennedy
authors.forename: B N
authors.initials: BN
authors.lastname: Wilkie
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001724:Birth Weight / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006649:Histocompatibility Antigens / Q000235:genetics*; D006823:Hybrid Vigor; D016018:Least-Squares Analysis; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D015233:Models, Statistical; D013552:Swine; D013556:Swine, Miniature / Q000235:genetics* / Q000254:growth & development; D014886:Weaning; D015430:Weight Gain / Q000235:genetics*
chemical_list: D006649:Histocompatibility Antigens