Acute toxicity of taxine in mice and rats.
The acute toxicity of taxine isolated from leaves of yew trees was determined in mice and rats. The drug was used as the sulphate salt. The following LD50 values (mg/kg) and 95% confidence limits were found: mice po 19.72 (16.84-23.09); mice ip 21.88 (19.66-24.35); rats sc 20.18 (18.35-22.20).
Tekol
Y
Y
Department of Pharmacology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000633:toxicity*; D010939:Plant Poisoning / Q000150:complications*; D051381:Rats; D043823:Taxoids
D000470:Alkaloids; D010936:Plant Extracts; D043823:Taxoids; C047703:taxine