title: Persistence of respiratory abnormalities four years after the onset of toxic oil syndrome.
abstract: We studied a random sample of 436 subjects with TOS aged 18 to 60 years, to assess the prevalence of respiratory involvement four years after onset of the syndrome. Clinical evaluation together with chest roentgenograms, electrocardiogram and functional respiratory tests were carried out. Respiratory involvement occurred in 390 (89.4 percent) individuals and was the most common abnormality detected, followed by neurological disorders in 289 (66.3 percent), osteoarticular symptoms in 171 (39.2 percent), psychiatric disorders in 96 (22 percent), hepatic involvement in 91 (20.9 percent), and sclerodermatous sequelae in 89 (20.4 percent). Among patients with respiratory involvement, dyspnea and cough were the most common complaints. Decreased VC was observed in 151 (34.6 percent) patients and reduced transfer factor of CO in 95 (21.8 percent) patients. Airway obstruction and alveolar hypoventilation were observed only in nine (2.1 percent) patients. Six (1.4 percent) patients suffered from pulmonary artery hypertension.
authors.affiliation: Department of Pneumology, Hospital 12 de Octubre, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Martín Escribano
authors.forename: M J
authors.initials: MJ
authors.lastname: Díaz de Atauri
authors.forename: M A
authors.initials: MA
authors.lastname: Gómez Sánchez
mesh_terms: D000293:Adolescent; D000328:Adult; D001937:Brassica; D002245:Carbon Dioxide / Q000097:blood / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010938:Plant Oils / Q000506:poisoning*; D015995:Prevalence; D000074262:Rapeseed Oil; D012140:Respiratory Tract Diseases / Q000453:epidemiology*; D012907:Smoking / Q000453:epidemiology; D013030:Spain / Q000453:epidemiology; D013997:Time Factors; D014797:Vital Capacity
chemical_list: D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils; D000074262:Rapeseed Oil; D002245:Carbon Dioxide; D010100:Oxygen