Effects of exercise and ethanol ingestion on platelet thromboxane release in healthy men.
We studied the effects of repeated bicycle exercises and ethanol ingestion (1.5 g/kg) on platelet aggregation and thromboxane (TxB2) release in 10 healthy male volunteers. After a bicycle exercise performed in the morning, the adenosine diphosphate (ADP)-induced platelet aggregation and the aggregation-associated thromboxane release were found to be decreased in fasting men. In contrast, after ingestion of fruit juice and a second exercise at noon, platelet aggregation and thromboxane release were increased. These latter changes were negligible when ethanol was ingested together with fruit juice. A third exercise, performed in the evening, again caused a decrease in the aggregation and associated thromboxane release during the control session, but provoked an increase during the ethanol session. Exercise increased the urinary excretion of 2,3-dinor-6-keto-PGF1 alpha. Changes in the plasma arachidonic acid (AA) concentration probably influenced the platelet thromboxane release. The results suggest that both physical exercise and ingestion of ethanol in fruit juice influence the ADP-stimulated platelet thromboxane release.
Numminen
H
H
Department of Neurology, University of Helsinki, Finland.
Hillbom
M
M
Vapaatalo
H
H
Seppälä
E
E
Laustiola
K
K
Benthin
G
G
Muuronen
A
A
Kaste
M
M
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000428:Alcohol Drinking; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D001794:Blood Pressure; D015444:Exercise; D006339:Heart Rate; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D012016:Reference Values; D013929:Thromboxane B2 / Q000097:blood*; D014841:von Willebrand Factor / Q000032:analysis
D001095:Arachidonic Acids; D014841:von Willebrand Factor; D016718:Arachidonic Acid; D013929:Thromboxane B2; D000244:Adenosine Diphosphate