Myelodysplastic syndrome and acquired factor VIII inhibitor with severe subcutaneous haemorrhage.
A case of acquired haemophilia A presenting with extensive spontaneous bruising and anaemia is reported. The anaemia was due to myelodysplastic syndrome (FAB: refractory anaemia with ringed sideroblasts). A factor-VII:C-specific inhibitor was also found. Prednisone and pyridoxine were given, and the inhibitor became undetectable after 4 weeks of therapy, but the abnormal ringed sideroblasts still persisted on repeated bone marrow biopsy.
Lin
C K
CK
Department of Pathology, Queen Mary Hospital, University of Hong Kong.
Liang
R
R
Liu
H W
HW
Tse
P W
PW
Chan
G T
GT
D000368:Aged; D000756:Anemia, Sideroblastic / Q000209:etiology / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D005260:Female; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000150:complications*; D011241:Prednisone / Q000627:therapeutic use; D011736:Pyridoxine / Q000627:therapeutic use
D005169:Factor VIII; D011736:Pyridoxine; D011241:Prednisone