title: The immune response. 2. Systemic mediators of inflammation.
abstract: This article deals with the mechanisms by which local immune stimulation is transmitted to the periphery, leading to systemic inflammation. We concentrate on the role of three signalling molecules: interleukin-1, interleukin-6, and tumour necrosis factor alpha. These cytokines provide a direct link between local and systemic inflammation.
authors.affiliation: Department of Rheumatology, University of Birmingham.
authors.forename: P
authors.initials: P
authors.lastname: Emery
authors.forename: M
authors.initials: M
authors.lastname: Salmon
mesh_terms: D000210:Acute-Phase Reaction; D000818:Animals; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007375:Interleukin-1 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha