title: Dolichol levels during development and ageing of Drosophila melanogaster.
abstract: 1. Dolichol levels in the fruit fly, Drosophila melanogaster were determined at the larva and pupa stages and in 1, 10, 20 and 30-day-old flies. 2. Free dolichol increased from 1.2 micrograms/g wet weight in the larvae to 14.9 micrograms/g in 30-day-old flies, while total dolichol increased from 3.4 micrograms/g in the larvae to 21.2 micrograms/g at 30-days-old. 3. Dolichol released after saponification is primarily from dolichyl fatty acid ester, which accounts for up to 65% of the total dolichol. 4. The major dolichol homologs, which remain relatively constant throughout development and ageing in D. melanogaster, are C-80, C-85 and C-90, which represent approximately 7%, 60% and 33%, respectively.
authors.affiliation: New York State Office of Mental Retardation and Developmental Disabilities, Staten Island, NY 10314.
authors.forename: G N
authors.initials: GN
authors.lastname: Morris
authors.forename: R K
authors.initials: RK
authors.lastname: Pullarkat
mesh_terms: D000375:Aging; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004286:Dolichols / Q000737:chemistry / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000254:growth & development* / Q000378:metabolism; D007814:Larva / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D011679:Pupa / Q000378:metabolism; D013045:Species Specificity; D013552:Swine
chemical_list: D004286:Dolichols