title: Effect of growth temperature on virulence of strains of Listeria monocytogenes in the mouse: evidence for a dose dependence.
abstract: Growth of Listeria monocytogenes at 4 degrees C significantly increased its virulence for mice by the intravenous route and the effect was dose-dependent. Virulence was apparent only at a dose of about or above 10(4) viable listerias. At slightly lower doses of about 10(3), no such effect was observed. Growth at 4 degrees C did not increase the virulence of the strains for mice by oral-gastric challenge when given at doses of approximately 10(10).
authors.affiliation: Department of Microbiology, University of Leicester, UK.
authors.forename: J C
authors.initials: JC
authors.lastname: Stephens
authors.forename: I S
authors.initials: IS
authors.lastname: Roberts
authors.forename: D
authors.initials: D
authors.lastname: Jones
authors.forename: P W
authors.initials: PW
authors.lastname: Andrew
mesh_terms: D000818:Animals; D005260:Female; D008089:Listeria monocytogenes / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity*; D008088:Listeriosis / Q000382:microbiology*; D008099:Liver / Q000382:microbiology; D051379:Mice; D013154:Spleen / Q000382:microbiology; D013696:Temperature; D014774:Virulence