title: The effect of nitroglycerin on pulmonary vascular capacitance in dogs.
abstract: In this study we investigated the hypothesis that the decrease in pulmonary vascular pressures observed after administration of nitroglycerin is in part due to a shift in the pulmonary vascular pressure-volume relationship. The experiments were done in six closed-chest dogs anesthetized with pentobarbital, in which pulmonary, cardiac, and intestinal relative blood volumes were determined by equilibrium blood pool scintigraphy. Nitroglycerin (30 micrograms/kg/min) caused 7% (p less than 0.02) and 12% (p less than 0.02) reductions in pulmonary and total cardiac blood volume, respectively, and a 7% (p less than 0.01) increase in intestinal blood volume. This shift of blood from the heart and the pulmonary circulation to the systemic (intestinal) circulation was accompanied by reductions in mean pulmonary artery pressure from 16 +/- 2 mm Hg to 12 +/- 1 mm Hg (p less than 0.01), in mean pulmonary capillary wedge pressure from 11 +/- 2 mm Hg to 6 +/- 1 mm Hg (p less than 0.01), and in mean portal pressure from 9 +/- 1 mm Hg to 8 +/- 1 mm Hg (p less than 0.01). The position of the pulmonary vascular pressure-blood volume relationship was unaffected by nitroglycerin, whereas the portal pressure-intestinal blood volume relationship was shifted to the left and upward. These changes suggest that pulmonary vascular tone remained unchanged, whereas intestinal vascular tone decreased during administration of nitroglycerin. In conclusion, nitroglycerin decreased pulmonary vascular pressures through a passive emptying of the pulmonary circulation as a result of increased systemic (intestinal) vascular capacitance.
authors.affiliation: Department of Medicine, University of Calgary, Alberta, Canada.
authors.forename: O A
authors.initials: OA
authors.lastname: Smiseth
authors.forename: D E
authors.initials: DE
authors.lastname: Manyari
authors.forename: N W
authors.initials: NW
authors.lastname: Scott-Douglas
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: I
authors.initials: I
authors.lastname: Kingma
authors.forename: E R
authors.initials: ER
authors.lastname: Smith
authors.forename: J V
authors.initials: JV
authors.lastname: Tyberg
mesh_terms: D000818:Animals; D001810:Blood Volume / Q000187:drug effects; D004285:Dogs; D015637:Gated Blood-Pool Imaging; D005996:Nitroglycerin / Q000494:pharmacology*; D011652:Pulmonary Circulation / Q000187:drug effects*; D011669:Pulmonary Wedge Pressure / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D005996:Nitroglycerin