title: Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm.
abstract: Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.
authors.affiliation: Institute of Medical Microbiology, University of Copenhagen, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Giwercman
authors.forename: E T
authors.initials: ET
authors.lastname: Jensen
authors.forename: N
authors.initials: N
authors.lastname: Høiby
authors.forename: A
authors.initials: A
authors.lastname: Kharazmi
authors.forename: J W
authors.initials: JW
authors.lastname: Costerton
mesh_terms: D003470:Culture Media; D004790:Enzyme Induction / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D015378:Imipenem / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010878:Piperacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000201:enzymology*; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D003470:Culture Media; D015378:Imipenem; D001618:beta-Lactamases; D010878:Piperacillin