title: [The structure and antimicrobial activity of the partial degradation products of the antibiotic eremomycin].
abstract: Antimicrobial activity of partial degradation products of eremomycin, a new glycopeptide antibiotic, was studied. The products formed by eremomycin deglycosylation (deseremosaminyl eremomycin, eremosaminyl aglycone and aglycone) and elimination of the chlorine atom from the molecule aglycone moiety (dechloroeremomycin). The spectral data in favour of the compounds structure are presented. It was found that partial degradation led to a decrease in the antimicrobial activity of the antibiotic. Dechloreremomycin had the highest activity among the products. Its MIC for the methicillin-resistant strains of Staphylococcus aureus was only twice as low as that of the initial antibiotic.
authors.forename: T F
authors.initials: TF
authors.lastname: Berdnikova
authors.forename: N N
authors.initials: NN
authors.lastname: Lomakina
authors.forename: E N
authors.initials: EN
authors.lastname: Olsuf'eva
authors.forename: L G
authors.initials: LG
authors.lastname: Aleksandrova
authors.forename: N P
authors.initials: NP
authors.lastname: Potapova
authors.forename: B V
authors.initials: BV
authors.lastname: Rozynov
authors.forename: I V
authors.initials: IV
authors.lastname: Malkova
authors.forename: G I
authors.initials: GI
authors.lastname: Orlova
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006020:Glycopeptides / Q000032:analysis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C053759:eremomycin
vernacular_title: Struktura i antimikrobnaia aktivnost' produktov chastichnoĭ degradatsii antibiotika éremomitsina.