Misoprostol does not alter the pharmacokinetics of propranolol.
Twelve healthy volunteers took part in a randomised, double-blind, balanced, cross-over study to investigate the effect of misoprostol on the pharmacokinetics of propranolol. The subjects took propranolol 80 mg twice daily by mouth plus either misoprostol 400 micrograms twice daily or placebo by mouth for 14.5 days, followed by a 2-week washout period, followed by the alternate treatment for 14.5 days. Misoprostol had no significant effect on the t/2, Cmax or AUC of propranolol either after a single dose or at steady state.
Bennett
P N
PN
Clinical Pharmacology Unit, Royal United Hospital, Combe Park, Bath, UK.
Fenn
G C
GC
Notarianni
L J
LJ
Lee
C E
CE
D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D016595:Misoprostol; D011433:Propranolol / Q000493:pharmacokinetics*
D000897:Anti-Ulcer Agents; D016595:Misoprostol; D011433:Propranolol; D000527:Alprostadil