title: Renal failure is a common complication in non-immune Europeans with Plasmodium falciparum malaria.
abstract: Renal failure in malaria appears to be a complication less well known than anaemia and cerebral malaria. Thirty-one non-immune patients treated for Plasmodium falciparum malaria at Hannover Medical School were reviewed. Nine patients (29%) had acute renal failure, seven of whom required dialysis, and five patients needed mechanical ventilation. Cerebral symptoms were seen in nine patients, and three of the patients died. In a second series, information about patients who died of malaria in Germany and Austria was gathered. Thirty-six reports were obtained and analysed retrospectively. Thirty-four patients (94%) had acute renal failure. Eighteen patients received dialysis while five other patients with high central venous pressure or hyperkalaemia would have benefitted from dialysis. Cerebral involvement was seen in 34 patients, and 20 patients showed respiratory failure. It was concluded that renal failure in P. falciparum malaria is as common in non-immune adults as cerebral malaria. As untreated renal failure may have a deleterious influence on cerebral and respiratory functions, early dialysis-treatment in patients with severe P. falciparum malaria and signs of deteriorating renal function is recommended.
authors.affiliation: Kinderklinik, Medizinische Hochschule, Hannover, Germany.
authors.forename: M W
authors.initials: MW
authors.lastname: Weber
authors.forename: K
authors.initials: K
authors.lastname: Böker
authors.forename: R D
authors.initials: RD
authors.lastname: Horstmann
authors.forename: J H
authors.initials: JH
authors.lastname: Ehrich
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001317:Austria; D001803:Blood Transfusion; D001927:Brain Diseases / Q000209:etiology; D003404:Creatinine / Q000097:blood; D005260:Female; D005858:Germany; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008288:Malaria / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum; D006435:Renal Dialysis; D012189:Retrospective Studies
chemical_list: D006454:Hemoglobins; D003404:Creatinine