title: Unusual translocations and other changes in acute leukemia.
abstract: We report three cases of ANLL and one case of ALL in which we found chromosome abnormalities not previously described. The first patient had a (9;11;16)(p22;q23;p13) translocation in the relapse after bone marrow transplantation. In the second case, a secondary leukemia following a Wilms' tumor, there was a single chromosome anomaly, an inversion of chromosome 13. The third case also presented an isochromosome 13q. In the fourth patient we observed a translocation between two achrocentric chromosomes, as in the third patient, but not of the Robertsonian type: t(21;21)(q22.1;q22.5).
authors.affiliation: Medical Genetics Dept., Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: M T
authors.initials: MT
authors.lastname: Ferro
authors.forename: E
authors.initials: E
authors.lastname: del Potro
authors.forename: I
authors.initials: I
authors.lastname: Krsnik
authors.forename: A
authors.initials: A
authors.lastname: Villegas
authors.forename: J M
authors.initials: JM
authors.lastname: Fernández-Rañada
authors.forename: M
authors.initials: M
authors.lastname: Resino
authors.forename: J M
authors.initials: JM
authors.lastname: García-Sagredo
authors.forename: C
authors.initials: C
authors.lastname: San-Román
mesh_terms: D000293:Adolescent; D000368:Aged; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D002882:Chromosomes, Human, Pair 13; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic