The big bang and its universal hernias. A sire of pathologies.
The 'Big Bang' is used to describe the origin of the Universe. While such an event could not create itself the expression is graphic. Tissue damage, traumatic, thermal, chemical; bites; insect, animal or human are all bad, but also well known factors which favor and initiate pathogenic activity. Antedating and outranking all those is the inherent tendency of the universal contractile chamber to rupture and spill its contents, especially when mural labors encounter sphincteric intransigence. This is a newer concept of pathology more basic than infection, allergy, cancer, trauma, etc. The phenomenon is also an important part of the mechanisms whereby those unessential factors pathologize making various kinds of 'itis'. The mammalian body is composed of contractile tubes and bags. So one might call their universal inherent tendency to herniate, i.e., to burst and leak, the Father of pathologies, but the Big Bang seems more descriptive.
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D000818:Animals; D006547:Hernia / Q000209:etiology; D006801:Humans; D008954:Models, Biological; D010336:Pathology