[Changes in the cerebral hemodynamics under the influence of piracetam and fenibut during motion sickness].
In the experiments on conscious rabbits with the electrodes implanted in the brain it was found by the methods of hydrogen clearance and polarography that piracetam (50 and 500 mg/kg) and phenibut (50 mg/kg) induced a decrease of the local blood flow in the cortex of the frontal, temporal and occipital regions and the total cerebral blood flow. The administration of the drugs before tilting prevents the occurrence of vasodilatation in the brain and results in a decrease of the blood flow in the cortex and in the confluence of the cerebral venous sinuses that is thought to be connected with the mechanism of an increase of the vestibular stability under the influence of GABA derivatives.
Skoromnyĭ
N A
NA
Beketov
A I
AI
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004567:Electrodes, Implanted; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D008297:Male; D009041:Motion Sickness / Q000503:physiopathology*; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D010313:Partial Pressure; D010889:Piracetam / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014149:Tranquilizing Agents / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D014149:Tranquilizing Agents; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid; D010889:Piracetam
Izmeneniia tserebral'noĭ gemodinamiki pod vliianiem piratsema i fenibuta pri ukachivanii.