title: A cytotoxic substance from Sangre de Grado.
abstract: Taspine has been isolated as a cytotoxic substance from Sangre de Grado, sap of Croton palanostigma (Euphorbiaceae), by bioassay guided fractionation. The cytotoxicity (IC50) of taspine was found to be 0.39 microgram/ml against KB cells and 0.17 microgram/ml against V-79 cells.
authors.affiliation: Tokyo College of Pharmacy, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Itokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ichihara
authors.forename: M
authors.initials: M
authors.lastname: Mochizuki
authors.forename: T
authors.initials: T
authors.lastname: Enomori
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: O
authors.initials: O
authors.lastname: Shirota
authors.forename: M
authors.initials: M
authors.lastname: Inamatsu
authors.forename: K
authors.initials: K
authors.lastname: Takeya
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; C018394:taspine