B and T lymphocytes are affected in lysosomal disorders--an immunoelectron microscopic study.
Circulating lymphocytes of four patients with mucopolysaccharidoses II and IIIA, four patients with juvenile neuronal ceroid-lipofuscinosis, one patient each with glycogenosis type II, infantile neuronal ceroid-lipofuscinosis, and Gaucher disease were classified by immunoelectron microscopy as B or T lymphocytes. Disease-specific lysosomal inclusions as well as non-specific lysosomal organelles, especially Gall bodies were identified in B and T lymphocytes. These non-quantitative studies indicate that both B and T lymphocytes participate in the lysosomal storage process.
Brück
W
W
Division of Neuropathology, University of Mainz, FRG.
Goebel
H H
HH
Dienes
P
P
D001402:B-Lymphocytes / Q000502:physiology / Q000648:ultrastructure*; D006801:Humans; D008661:Metabolism, Inborn Errors / Q000097:blood*; D016253:Microscopy, Immunoelectron; D013601:T-Lymphocytes / Q000502:physiology / Q000648:ultrastructure*