Pharmacological modulation of a model of bronchial inflammation after aerosol-induced active anaphylactic shock in conscious guinea pigs.
Twenty-four hours after an active anaphylactic shock induced by inhalation of antigen in conscious guinea pigs sensitized by a large dose of ovalbumin in complete Freund's adjuvant, a noteworthy bronchial inflammation, characterized by increased numbers of neutrophils, mononuclear cells and eosinophils in the bronchoalveolar lavage fluid, was observed. Some drugs administered after the anaphylactic shock were investigated using this model. Disodium cromoglycate primarily reduced the number of mononuclear cells and eosinophils. Dexamethasone and theophylline decreased the number of eosinophils. Salbutamol and mepyramine increased neutrophils. Indomethacin did not give rise to any significant effect. This test appears to be of use for the investigation of anti-inflammatory compounds in the prophylactic treatment of asthma.
Tarayre
J P
JP
Centre de Recherche Pierre Fabre, Castres, France.
Aliaga
M
M
Barbara
M
M
Tisseyre
N
N
Vieu
S
S
Tisne-Versailles
J
J
D000420:Albuterol / Q000627:therapeutic use*; D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000517:prevention & control; D001991:Bronchitis / Q000188:drug therapy* / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004195:Disease Models, Animal; D006168:Guinea Pigs; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D011738:Pyrilamine / Q000627:therapeutic use*
D003907:Dexamethasone; D010047:Ovalbumin; C018038:dexamethasone acetate; D011738:Pyrilamine; D004205:Cromolyn Sodium; D000420:Albuterol