title: [Current approach to hygienic evaluation of protective and damaging reactions of the immune system after exposure to environmental factors].
abstract: When studying the immune status of the organism the use of additional exposures allow to clear up the defective character of physiological functions even when overt changes are absent. Altitude chamber hypoxia++, reproduction of allergic reactions of the slow and non-slow types, pathogenic Escherichia infection followed by assessment of virulence factors were used as such a stress under exposure to chemicals, electromagnetic fields of radio frequencies. A model was developed for the determination of safe levels of exposure to environmental factors, which makes it possible to differentiate the damaging and defence action of antibodies on the basis of their influence on the fetus and offspring. The effects of antibodies characterized by the postimplantation mortality of fetuses may be used as a criterion of significance for the organism of shifts in immunological reactivity.
authors.forename: M G
authors.initials: MG
authors.lastname: Shandala
authors.forename: G I
authors.initials: GI
authors.lastname: Vinogradov
authors.forename: L V
authors.initials: LV
authors.lastname: Grigor'eva
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D004195:Disease Models, Animal; D005260:Female; D005313:Fetal Death / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D005333:Fetus / Q000276:immunology; D006168:Guinea Pigs; D000860:Hypoxia / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D008168:Lung / Q000187:drug effects / Q000276:immunology*; D011247:Pregnancy; D051381:Rats
chemical_list: D000393:Air Pollutants; D001323:Autoantibodies
vernacular_title: Sovremennye podkhody k gigienicheskoĭ otsenke zashchitnykh i povrezhdaiushchikh reaktsiĭ immunnoĭ sistemy organizma pri vozdeĭstvii faktorov okruzhaiushcheĭ sredy.