title: Chemical properties and anti-complementary activities of heteroglycans from the leaves of Panax ginseng.
abstract: Four anti-complementary neutral (GL-NIa and GL-NIb) and acidic (GL-AIa and GL-AIb) polysaccharides were purified from the leaves of Panax ginseng C. A. Meyer. Only GL-NIa and GL-AIa exhibited potent anti-complementary activities at low concentrations probably through the alternative complement pathway. Glycosyl linkage analysis demonstrated that GL-NIa mainly consisted of arabinogalactan moieties, whereas GL-NIb contained large amounts of (1----4)-linked glucosyl residues. Beta-Elimination indicated that GL-AIa and GL-AIb were pectic polysaccharides consisting of a rhamnogalacturonan core with neutral side chains. GL-AIa reacted strongly with beta-glucosyl-Yariv antigen, GL-NIa reacted weakly, whereas GL-NIb and GL-AIb showed no reaction with the antigen.
authors.affiliation: Oriental Medicine Research Center, Kitasato Institute, Tokyo, Japan.
authors.forename: Q P
authors.initials: QP
authors.lastname: Gao
authors.forename: H
authors.initials: H
authors.lastname: Kiyohara
authors.forename: J C
authors.initials: JC
authors.lastname: Cyong
authors.forename: H
authors.initials: H
authors.lastname: Yamada
mesh_terms: D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000032:analysis; D003169:Complement Inactivator Proteins / Q000737:chemistry / Q000302:isolation & purification; D008969:Molecular Sequence Data; D005894:Panax / Q000032:analysis*; D010946:Plants, Medicinal; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D002241:Carbohydrates; D003169:Complement Inactivator Proteins; D011134:Polysaccharides