Response of depression to very high plasma levels of imipramine plus desipramine.
Forty-five depressed patients were treated with imipramine for 6 weeks. Seven of 7 patients (100%) who had plasma levels of imipramine plus desipramine greater than 500 ng/ml showed a 50% or greater improvement in Hamilton depression scores compared with 23 of 38 patients (60%) with plasma levels less than 500 ng/ml (p less than 0.057).
Garvey
M
M
Department of Psychiatry, University of Iowa College of Medicine, Iowa City.
DeRubeis
R J
RJ
Hollon
S D
SD
Evans
M D
MD
Tuason
V B
VB
D000328:Adult; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D003891:Desipramine / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D008297:Male; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics
D007099:Imipramine; D003891:Desipramine