title: Effects of perinatal polychlorinated biphenyls and dichlorodiphenyl dichloroethene on later development.
abstract: OBJECTIVE
  Determining whether early developmental effects of perinatal exposure to polychlorinated biphenyls (PCBs) or dichlorodiphenyl dichloroethene (DDE) persist.
  
  
  METHODS
  Cohort followed from birth; ages now 5 1/2 to 10 1/2 years.
  
  
  METHODS
  General community.
  
  
  METHODS
  Volunteer sample of 859 children, of whom 712 had been examined with the McCarthy Scales of Children's Abilities at 3, 4, or 5 years; 506 sent report cards.
  
  
  METHODS
  None.
  
  
  RESULTS
  Neither transplacental nor breast-feeding exposure to PCBs or DDE affected McCarthy scores at 3, 4, or 5 years. There was no statistically significant relationship between poorer grades and PCB or DDE exposure by either route.
  
  
  CONCLUSIONS
  The deficits seen in these children on the Bayley Scales of Infant Development through 2 years of age are no longer apparent.
authors.affiliation: Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
authors.forename: B C
authors.initials: BC
authors.lastname: Gladen
authors.forename: W J
authors.initials: WJ
authors.lastname: Rogan
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D002648:Child; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D015331:Cohort Studies; D003632:Dichlorodiphenyldichloroethane / Q000032:analysis / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D011078:Polychlorinated Biphenyls; D003632:Dichlorodiphenyldichloroethane