Polyol pathway in tissues of spontaneously diabetic Chinese hamsters (Cricetulus griseus) and the effect of an aldose reductase inhibitor, ONO-2235.
1. Sorbitol and fructose levels were significantly elevated in the lens, the sciatic nerve, the retina and the kidney of diabetic Chinese hamsters and inositol level was significantly decreased in the lens and sciatic nerve of diabetics. 2. The activity of an aldose reductase in the kidney was not different between normal and diabetic Chinese hamsters. 3. An aldose reductase inhibitor (ONO-2235) had no effect in sorbitol, fructose and inositol contents of all these tissues from diabetic Chinese hamsters. 4. These results suggest that diabetic Chinese hamsters produce polyol accumulation in tissues but that there is a clear species-specific difference to inhibition of aldose reductase.
Sekiguchi
M
M
Second Department of Internal Medicine, Asahikawa Medical College, Japan.
Watanabe
K
K
Eto
M
M
Iwashima
Y
Y
Morikawa
A
A
Takahashi
M
M
Ishii
K
K
Makino
I
I
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D005632:Fructose / Q000378:metabolism; D007294:Inositol / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007908:Lens, Crystalline / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011108:Polymers / Q000378:metabolism*; D012160:Retina / Q000187:drug effects / Q000378:metabolism; D012236:Rhodanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012584:Sciatic Nerve / Q000187:drug effects / Q000378:metabolism; D013012:Sorbitol / Q000378:metabolism; D053778:Thiazolidines
D011108:Polymers; D053778:Thiazolidines; C024617:polyol; D005632:Fructose; C038131:epalrestat; D007294:Inositol; D013012:Sorbitol; D012236:Rhodanine; D000449:Aldehyde Reductase