[Binding of mitoxantrone and ametantrone with poly(d(G-C)) on the B---Z transition, stimulated by NaCl].
Binding of antitumoral preparations mitoxantrone and ametantrone with right and left helical DNA was investigated. B-Z conformational transition stimulated by NaCl in the molecules of poly[d(G.C)].poly[d(G-C)] in complex with mitoxantrone and ametantrone was studied by the method of circular dichroism. It was shown that these compounds disturb B-Z transition but do not inhibit it.
Babaian
Iu S
IuS
Manzinii
D
D
Ksodo
L E
LE
D000970:Antineoplastic Agents / Q000378:metabolism*; D002942:Circular Dichroism; D008942:Mitoxantrone / Q000031:analogs & derivatives* / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D011089:Polydeoxyribonucleotides / Q000378:metabolism*; D012965:Sodium Chloride / Q000737:chemistry*
D000970:Antineoplastic Agents; D011089:Polydeoxyribonucleotides; C019530:poly(dC-dG); D012965:Sodium Chloride; D008942:Mitoxantrone; C020182:ametantrone
Sviazyvanie mitoksantrona i ametantrona s poli]d(G-Ts)], vliianie na perekhod V---Z, stimulirovannyĭ NaCl.