Comparison of the hemodynamic effects of endothelin-1 and big endothelin-1 in the rat.
We compared the hemodynamic effects of continuous i.v. infusion of endothelin-1 and big endothelin-1 in anesthetized rats. Big endothelin-1 was fivefold less potent than endothelin-1 in decreasing cardiac output, heart rate, and stroke volume. However, big endothelin-1 produced a significantly larger increase in mean arterial pressure compared to endothelin-1 at doses that produced identical decreases in cardiac output. These findings support the hypothesis that the hypertensive effects of big endothelin-1 and endothelin-1 are produced by differential effects on systemic vascular resistances.
Pollock
D M
DM
Abbott Laboratories, Abbott Park, IL 60064.
Opgenorth
T J
TJ
D000818:Animals; D019332:Endothelin-1; D016232:Endothelins / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D008297:Male; D011498:Protein Precursors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D019332:Endothelin-1; D016232:Endothelins; D011498:Protein Precursors