title: Nonsurgical treatment of drooling in a patient with closed head injury and severe dysarthria.
abstract: The purpose of this investigation was to measure the effectiveness of the antimuscarinic drug atropine sulfate in the treatment of chronic drooling in a patient with a history of severe closed head injury and resultant widespread oral neuromuscular and higher cortical disturbances. Results of the A-B-A-B-A-B withdrawal paradigm, chosen to demonstrate the functional relationship between drug therapy and the degree of drooling, revealed that administration of atropine sulfate reduced by more than 50% of baseline levels the amount of resting secretion, intraoral accumulation, and pharyngeal-laryngeal pooling of saliva, with negligible side effects. These results are discussed and compared to the alternative drug and surgical approaches to treatment that have been the primary focus of recent research on drooling.
authors.affiliation: University of Texas Medical Branch, Galveston.
authors.forename: J P
authors.initials: JP
authors.lastname: Dworkin
authors.forename: J C
authors.initials: JC
authors.lastname: Nadal
mesh_terms: D000328:Adult; D001285:Atropine / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D006259:Craniocerebral Trauma / Q000150:complications*; D004401:Dysarthria / Q000150:complications*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D012463:Saliva / Q000378:metabolism; D012798:Sialorrhea / Q000188:drug therapy* / Q000209:etiology; D014949:Wounds, Nonpenetrating / Q000150:complications*
chemical_list: D001285:Atropine