title: Effect of repeated oral administration of tobacco snuff on natural killer-cell activity in the rat.
abstract: The possible immune effect of oral snuff was investigated. In male adult rats, oral snuff given for 15 weeks significantly decreased NK-cell activity in peripheral blood against murine NK cell-sensitive target cells (YAC-1 lymphoma).
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.
authors.forename: S L
authors.initials: SL
authors.lastname: Johansson
authors.forename: J M
authors.initials: JM
authors.lastname: Hirsch
authors.forename: D R
authors.initials: DR
authors.lastname: Johnson
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002860:Chromium Radioisotopes; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000502:physiology; D008223:Lymphoma / Q000473:pathology; D008297:Male; D010947:Plants, Toxic; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014030:Tobacco, Smokeless / Q000009:adverse effects*
chemical_list: D002860:Chromium Radioisotopes