[Effects of allapinin on sodium currents in isolated neurons of the trigeminal ganglia and cardiomyocytes of rats].
Block of sodium currents by allapinin (diterpene alkaloid with strong antiarrhythmic properties) was investigated in isolated, voltage clamped rat trigeminal neurons and cultured neonatal rat single ventricular myocytes. Allapinin produces a decrease in sodium current amplitude without any changes in voltage dependent properties. Possible differences between the mechanisms of antiarrhythmic effect of diterpene alkaloids and classic antiarrhythmic agents have been analysed.
Valeev
A E
AE
Verkhratskiĭ
A N
AN
Dzhakhangirov
F N
FN
D000157:Aconitine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D002478:Cells, Cultured; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000166:cytology*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D051381:Rats; D012668:Trigeminal Ganglion / Q000187:drug effects* / Q000502:physiology
D000889:Anti-Arrhythmia Agents; C051402:allapinin; D002118:Calcium; D000157:Aconitine
Vliianie allapinina na natrievye toki izolirovannykh neĭronov trigeminal'nykh gangliev i kardiomiotsitov krys.