title: Necrotizing lymphadenitis--a clinico-pathologic study of 36 cases with immunohistochemical analysis.
abstract: Thirty-six cases of necrotizing lymphadenitis--including 33 cases of unknown etiology, 1 typhoid lymphadenopathy, and 2 cases of suspicious lupus lymphadenopathy--were clinico-pathologically reviewed and analyzed with immunostaining for s-100 and lysozyme. All cases histologically showed architectural effacement by paracortical lesions composed of nuclear karyorrhexis and mononuclear cell proliferation. Immunohistochemical study revealed proliferation of lysozyme-positive macrophages in the necrotizing areas and an increase in the number of s-100-positive cells in the uninvolved paracortical areas. This observation suggests that necrotizing lymphadenitis may be a common morphologic expression of a T cell-mediated hyperimmune condition induced by diverse etiologies.
authors.affiliation: Department of Pathology, Seoul National University College of Medicine, Korea.
authors.forename: K J
authors.initials: KJ
authors.lastname: Cho
authors.forename: C W
authors.initials: CW
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Park
authors.forename: S K
authors.initials: SK
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008199:Lymphadenitis / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009113:Muramidase / Q000378:metabolism; D009336:Necrosis; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D009418:S100 Proteins; D009113:Muramidase