TGF-beta: upregulator of HIV replication in macrophages.
TGF-beta at physiological concentrations, when added to monocyte-derived macrophages following HIV1 infection, has an enhancing effect upon the rate of virus production. This effect is observed with the monocytotropic isolate ADA, as well as with HIV1 IIIB, which poorly replicates in macrophages.
Lazdins
J K
JK
Ciba-Geigy, Ltd., Pharma Research, Basel, Switzerland.
Klimkait
T
T
Alteri
E
E
Walker
M
M
Woods-Cook
K
K
Cox
D
D
Bilbe
G
G
Shipman
R
R
Cerletti
N
N
McMaster
G
G
D002454:Cell Differentiation; D002478:Cells, Cultured; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008264:Macrophages / Q000166:cytology / Q000382:microbiology*; D009000:Monocytes / Q000166:cytology; D016212:Transforming Growth Factor beta / Q000502:physiology*; D015854:Up-Regulation; D014779:Virus Replication
D016212:Transforming Growth Factor beta