Hypoglycemic effect of swerchirin from the hexane fraction of Swertia chirayita.
A xanthone was isolated from the hexane fraction of the Swertia chirayita plant and identified as 1,8-dihydroxy-3,5-dimethoxyxanthone (swerchirin). It has a very significant blood sugar lowering effect in fasted, fed, glucose loaded, and tolbutamide pretreated albino rat models. The ED50 for 40% blood sugar lowering in CF male albino rats (body weight 140-165 g) is 23.1 mg/kg/oral. The possibility of its application in clinical therapy for diabetes mellitus needs exploration.
Bajpai
M B
MB
Central Drug Research Institute, Lucknow, India.
Asthana
R K
RK
Sharma
N K
NK
Chatterjee
S K
SK
Mukherjee
S K
SK
D000818:Animals; D007004:Hypoglycemic Agents / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D014966:Xanthenes / Q000302:isolation & purification / Q000494:pharmacology*; D044004:Xanthones
D007004:Hypoglycemic Agents; D014966:Xanthenes; D044004:Xanthones; C034385:swerchirin