The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene.
In the course of efforts to identify the neurofibromatosis type 1 gene (NF1), three genes were found embedded within an intron of NF1. The cDNA sequence of one of these genes (OMGP) encodes oligodendrocyte-myelin glycoprotein. OMGP spans at least 2.7 kb of genomic DNA, and it maps within 4 kb of the breakpoint of a balanced chromosomal translocation carried by an individual with NF1. OMGP is similar in genomic structure to two other expressed genes, EVI2A and EVI2B, which lie approximately 20 and 5 kb telomeric of the OMGP locus, respectively. All three genes have the same transcriptional orientation and are contained within one intron of NF1, which is transcribed off the opposite strand. Whether altered expression of OMGP might play a role in the clinical heterogeneity of NF1 is as yet unclear.
Viskochil
D
D
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132.
Cawthon
R
R
O'Connell
P
P
Xu
G F
GF
Stevens
J
J
Culver
M
M
Carey
J
J
White
R
R
D000595:Amino Acid Sequence; D001483:Base Sequence; D005075:Biological Evolution; D002460:Cell Line; D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1; D002886:Chromosomes, Human, Pair 17; D003001:Cloning, Molecular; D005260:Female; D058851:GPI-Linked Proteins; D015723:Gene Library; D006801:Humans; D007438:Introns; D008562:Membrane Glycoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009456:Neurofibromatosis 1 / Q000235:genetics*; D015183:Restriction Mapping; D014178:Translocation, Genetic
D058851:GPI-Linked Proteins; C571326:MOG protein, human; D008562:Membrane Glycoproteins; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D009419:Nerve Tissue Proteins; C560528:OMG protein, human