Inhibition of DNA synthesis and oncogene expression in tumor cells by the biological factor DIF.
A regulatory factor isolated from the maternal part of bovine placentas (decidua inhibitory factor, DIF) inhibits the incorporation of thymidine into the DNA of a variety of animal and human tumors. The degree of inhibition is dependent on the concentration of the factor. Results indicate that signal transduction occurs via a Ca2+ mobilizing pathway after specific binding of the inhibitor to tumor cell surface receptors. On of the main consequences of DIF action is the inhibition of c-fos and c-myc expression and/or degradation.
Letnansky
K
K
Institute of Applied and Experimental Oncology, University of Vienna, Austria.
Vetterlein
M
M
Shi
C
C
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000235:genetics; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects; D004075:Diglycerides / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D016259:Genes, myc / Q000187:drug effects; D006801:Humans; D051379:Mice; D010926:Placental Hormones / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D016760:Proto-Oncogene Proteins c-fos; D011519:Proto-Oncogenes / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012517:Sarcoma, Yoshida / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D004075:Diglycerides; D010926:Placental Hormones; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; C058985:decidua inhibitory factor; D004533:Egtazic Acid; C038237:1-oleoyl-2-acetylglycerol; D011505:Protein-Tyrosine Kinases; D002118:Calcium; D013936:Thymidine