Methylparathion, carbaryl and aldrin impact on nitrogen metabolism of prawn, Penaeus indicus.
Changes in hepatopancreas, muscle and gill tissue nitrogen metabolic profiles were studied in a penaeid prawn, Penaeus indicus, following its exposure to sublethal concentrations of methylparathion, carbaryl and aldrin. In all the insecticide exposed prawn tissues, Ammonia levels were significantly increased and a shift in the nitrogen metabolism towards the synthesis of urea and glutamine was observed. Inhibition of glutamate oxidation to ammonia and alpha-ketoglutarate by glutamate dehydrogenase suggests a mechanism whereby hyperammonemia is reduced by minimizing the addition of further ammonia to the already existing elevated ammonia pool. Increased alanine and aspartate aminotransferases demonstrates the onset of gluconeogenesis. Mechanisms to detoxify the ammonia by enhancing the synthesis of urea and glutamine at the cellular level was observed in the selected tissues pave way for the survivability of prawns in insecticide polluted environs.
Reddy
M S
MS
Department of Marine Zoology, Sri Venkateswara University Post-GraduateCenter, Kavali, India.
Rao
K V
KV
D000410:Alanine Transaminase / Q000378:metabolism; D000452:Aldrin / Q000494:pharmacology*; D000641:Ammonia / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D012721:Carbaryl / Q000494:pharmacology*; D005880:Gills / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008743:Methyl Parathion / Q000494:pharmacology*; D009132:Muscles / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism*; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D033561:Penaeidae / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D014508:Urea / Q000378:metabolism
D005973:Glutamine; D008743:Methyl Parathion; D000641:Ammonia; D014508:Urea; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D009584:Nitrogen; D000452:Aldrin; D012721:Carbaryl