Effects of carotenoid administration on bladder cancer prevention.
Bladder cancer was induced in male B6D2F1 strain mice by the administration of N-butyl-N-(4-hydroxybutyl)nitrosamine. Mice supplemented with beta-carotene for 5 weeks before receiving the carcinogen and maintained on beta-carotene for an additional 26 weeks developed significantly fewer tumors than did unsupplemented mice. Mice receiving canthaxanthin for the same time period showed no protection against the development of bladder cancer.
Mathews-Roth
M M
MM
Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Mass.
Lausen
N
N
Drouin
G
G
Richter
A
A
Krinsky
N I
NI
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002085:Butylhydroxybutylnitrosamine; D016644:Canthaxanthin; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced / Q000517:prevention & control*; D002338:Carotenoids / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010919:Placebos; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D000975:Antioxidants; D010919:Placebos; D002338:Carotenoids; D002085:Butylhydroxybutylnitrosamine; D016644:Canthaxanthin