title: Nucleotide sequence of the genes encoding the matrix protein of two wild-type measles virus strains.
abstract: The nucleotide sequences of the matrix protein (M) genes of two wild-type measles virus (MV) isolates (JM and CM) have been determined and shown to differ in 56 positions; 31 of these differences are located in the non-coding region and 25 in the coding region of the gene. Most (80%) of the mutations in the coding region are changes to the third base of a codon. A maximum parsimony analysis of the available M gene nucleotide sequences allowed the construction of a tree with at least three lineages or subtypes. One wild-type strain (JM) was very similar to a subacute sclerosing panencephalitis virus strain (case B); the second wild-type strain, CM, showed nucleotide sequence similarity with MV from a case of measles inclusion body encephalitis. Both wild-type virus sequences are distinct from those so far determined for vaccine strains.
authors.affiliation: Institute of Virology, University of Würzburg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Baczko
authors.forename: U
authors.initials: U
authors.lastname: Brinckmann
authors.forename: I
authors.initials: I
authors.lastname: Pardowitz
authors.forename: B K
authors.initials: BK
authors.lastname: Rima
authors.forename: V
authors.initials: V
authors.lastname: ter Meulen
mesh_terms: D000818:Animals; D005075:Biological Evolution; D003001:Cloning, Molecular; D004279:DNA, Viral / Q000737:chemistry; D004660:Encephalitis / Q000382:microbiology; D006801:Humans; D008457:Measles / Q000382:microbiology; D008459:Measles virus / Q000235:genetics*; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000737:chemistry*; D013344:Subacute Sclerosing Panencephalitis / Q000382:microbiology; D014709:Vero Cells; D014763:Viral Matrix Proteins / Q000235:genetics*
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral; D014763:Viral Matrix Proteins