Hexetidine mouthrinse in the management of minor aphthous ulceration and as an adjunct to oral hygiene.
A number of compounds have been used in the management of recurrent oral ulceration, including antimicrobials. This was a double-blind placebo-controlled cross-over study to assess the value of a 0.1% hexetidine mouthwash in the management of minor aphthous ulceration and as an adjunct to oral hygiene. Forty patients with a catalogued history of ulceration took part. Patients were randomly allocated to active/placebo or vice versa order of mouthwashes, which were used as 15 ml volumes three times a day. Treatment periods were 6 weeks with a 3 week washout. During each period patients kept daily records of the number, site, and duration of ulcers, together with pain scores. Plaque and gingivitis were scored at baseline and end of treatment periods. Thirty-eight patients completed the study, with no significant treatment differences between active and placebo rinses on any ulcer parameter. Additionally, the hexetidine rinse provided no significant benefit to oral hygiene or gingival health. However, there was a significant period effect, with considerable ulcer improvements during the second period, irrespective of treatment. In conclusion, the hexetidine rinse appeared to offer no benefits to these patients, but professional supervision of ulcer treatment does appear to result in a worthwhile placebo effect.
Chadwick
B
B
Department of Child Dental Health, Dental School, University of Wales College of Medicine, Cardiff.
Addy
M
M
Walker
D M
DM
D000293:Adolescent; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D006590:Hexetidine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes; D010512:Periodontal Index; D013281:Stomatitis, Aphthous / Q000188:drug therapy*
D009067:Mouthwashes; D006590:Hexetidine