Hyperintense basal ganglia on T1-weighted MR images in patients receiving parenteral nutrition.
Patterns of intracranial signal intensity on magnetic resonance (MR) images were studied in nine patients undergoing long-term total parenteral nutrition therapy. The duration of therapy ranged from 5 months to 11 years (mean, 5.3 years). Symmetric increased signal intensity on T1-weighted MR images (hyperintense relative to white matter) was observed in the basal ganglia of all patients, without corresponding abnormality on T2-weighted images. Analysis of signal-intensity characteristics and distribution pattern suggests that the basis for these changes may be deposition of intravenously administered paramagnetic trace elements, especially manganese, and/or an astrogliotic reaction to such deposition.
Mirowitz
S A
SA
Department of Radiology, Jewish Hospital, Washington University Medical Center, St Louis, MO 63110.
Westrich
T J
TJ
Hirsch
J D
JD
D001479:Basal Ganglia / Q000033:anatomy & histology* / Q000378:metabolism; D005260:Female; D005526:Food, Formulated; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008345:Manganese / Q000008:administration & dosage / Q000493:pharmacokinetics; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D013997:Time Factors; D014131:Trace Elements
D014131:Trace Elements; D008345:Manganese