title: Comparison of arterial and arterialized venous concentrations of propofol during infusion of propofol.
abstract: Seven patients received a series of low-dose propofol infusions designed to produce three successive pseudo-steady states of arterial blood concentration: 0.06, 0.17 and 0.43 micrograms ml-1. Arterial and arterialized venous blood samples were obtained simultaneously at the end of each infusion. The results indicate that 95% of the arterialized venous concentrations may be expected to lie within 1 +/- 43% of the corresponding arterial concentration, or -5 +/- 35% if one set of measurements with poor agreement between duplicate aliquots is omitted.
authors.affiliation: Department of Anaesthetics, University of Wales College of Medicine, Cardiff.
authors.forename: R W
authors.initials: RW
authors.lastname: Okell
authors.forename: W W
authors.initials: WW
authors.lastname: Mapleson
authors.forename: M D
authors.initials: MD
authors.lastname: Vickers
mesh_terms: D001158:Arteries / Q000502:physiology*; D006801:Humans; D007262:Infusions, Intravenous; D015742:Propofol / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D014680:Veins / Q000502:physiology*
chemical_list: D015742:Propofol