A double-blind study of misoprostol (SC-29333) in the healing of duodenal ulcer.
In a double-blind randomized placebo controlled trial, 50 patients with endoscopically confirmed duodenal ulcer were treated with either misoprostol 200 micrograms or placebo in q.i.d. doses for 4-8 weeks. Of 25 patients in the placebo group, four defaulted and two were withdrawn due to worsening of symptoms. Of 25 misoprostol-treated cases, 17 cases (68%) and 21 cases (84%) healed at 4 and 8 weeks respectively, compared with three (14%) and five (24%) of the 21 placebo-treated cases (P less than 0.001). Except for diarrhoea in 2 patients in each group and itching in one with misoprostol, no serious side effects were noted.
Ahmed
W U
WU
PMRC Research Centre, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
Qureshi
H
H
Alam
E
E
Zuberi
S J
SJ
D000328:Adult; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D016595:Misoprostol / Q000627:therapeutic use*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D016595:Misoprostol