A cytotoxic substance from Sangre de Grado.
Taspine has been isolated as a cytotoxic substance from Sangre de Grado, sap of Croton palanostigma (Euphorbiaceae), by bioassay guided fractionation. The cytotoxicity (IC50) of taspine was found to be 0.39 microgram/ml against KB cells and 0.17 microgram/ml against V-79 cells.
Itokawa
H
H
Tokyo College of Pharmacy, Japan.
Ichihara
Y
Y
Mochizuki
M
M
Enomori
T
T
Morita
H
H
Shirota
O
O
Inamatsu
M
M
Takeya
K
K
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; C018394:taspine