Total parenteral nutrition-induced steatosis: reversal by parenteral lipid infusion.
Prolonged use of total parenteral nutrition (TPN) may be associated with hepatic complications, primarily steatosis and cholestasis. A case is reported of an 18-year-old woman with chronic idiopathic intestinal pseudo-obstruction syndrome who was on prolonged home parenteral nutrition without lipid supplementation and developed steatosis. This finding was reversed by addition of lipid emulsion, at a dose of 0.5 g/kg/day, to the parenteral nutrition solution. The lack of lipid supplementation as a possible cause of steatosis, as well as other mechanisms of liver steatosis associated with TPN, are discussed.
Reif
S
S
Division of Gastroenterology, Children's Hospital of Buffalo, New York.
Tano
M
M
Oliverio
R
R
Young
C
C
Rossi
T
T
D000293:Adolescent; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology* / Q000628:therapy; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
D005217:Fat Emulsions, Intravenous