title: Detomidine reduces the plasma catecholamine, but not cortisol concentrations in horses.
abstract: Single doses of the alpha 2-adrenergic sedative-analgesic drug, detomidine (10 micrograms/kg, n = 7; 20 micrograms/kg, n = 9), were administered IV to adult horses. Plasma concentrations of adrenaline, noradrenaline, the catecholamine metabolites 3,4-dihydroxyphenylglycol (DHPG) and 3,4-dihydroxyphenylacetic acid (DOPAC), and cortisol were determined before the medication and 30 minutes after it. The plasma concentrations of noradrenaline and the catecholamine metabolites decreased significantly after administration of both 10 micrograms/kg and 20 micrograms/kg of detomidine. Plasma adrenaline level had a tendency to decrease, but plasma cortisol levels were not influenced. The findings suggest a reduction in sympatho-adrenal activity in horses treated with detomidine.
authors.affiliation: College of Veterinary Medicine, Department of Clinical Sciences, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Raekallio
authors.forename: O
authors.initials: O
authors.lastname: Vainio
authors.forename: M
authors.initials: M
authors.lastname: Scheinin
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000097:blood*; D005260:Female; D006734:Horse Diseases / Q000097:blood; D006736:Horses / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D013312:Stress, Physiological / Q000097:blood / Q000662:veterinary
chemical_list: D002395:Catecholamines; D007093:Imidazoles; C041255:detomidine; D006854:Hydrocortisone