Central nervous pathways underlying synchronization of human motor unit firing studied during voluntary contractions.
1. Motor unit firing has been studied during weak voluntary isometric contractions with pairs of needle electrodes in normal human subjects. 2. Pre- and post-stimulus time histograms of the firing time of firing of one event unit before and after the time of firing of another reference (stimulus) unit showed a clear central peak, indicative of synchronization. 3. Synchronization was seen in all the muscles studied. The mean strength of synchronization, expressed as the number of concomitant discharges of the two units as a proportion of the number of stimulus unit discharges, was 0.095 extra event unit spikes/reference unit spike (range 0.042-0.28) for first dorsal interosseous muscle, 0.016 extra event unit spikes per reference unit spike (range 0-0.043) for medial gastrocnemius and 0.056 extra event unit spikes per reference unit spike range 0.016-0.079) for tibialis anterior. 4. The mean duration of synchronization was 11.3 ms (range 5.0-21.0 ms) for first dorsal interosseous, 10.3 ms (range 3.5-21.7 ms) for medial gastrocnemious and 13.5 ms (range 3.0-25.0) for tibialis anterior. 5. Seven patients with radiographically and clinically identified central strokes were studied while they made weak voluntary isometric contractions. The duration of synchronization was significantly prolonged compared to that found in normal subjects. In these stroke patients the mean duration of synchronization on the affected side was longer than that seen in the normal subjects, and in first dorsal interosseous muscle was 35.4 ms (range 12.0-65.0 ms), in medial gastrocnemius was 21.3 ms (range 4.0-43.0 ms) and in tibialis anterior was 28.8 ms (range 14.0-49.0 ms). 6. The mean strength of synchronization of motor unit discharge was found to be greater in the stroke patients than that seen in the normal subjects for first dorsal interosseous muscle (0.161 extra event unit spikes per reference unit spike, range 0.017-0.391) and for medial gastrocnemius (0.030 extra event unit spikes per reference unit spike) but only significantly so when pooled data was compared. There was no difference in the strength of motor unit synchronization in tibialis anterior between stroke patients and normal subjects. 7. Broad duration synchronization among first dorsal interosseous motor units was also found in a patient with a rostral cervical spine lesion (total duration range 43-46 ms; n = 2), but not in a patient with a caudal (thoracic) spinal lesion.(ABSTRACT TRUNCATED AT 400 WORDS)
Datta
A K
AK
Department of Medicine, Charing Cross and Westminster Medical School, London.
Farmer
S F
SF
Stephens
J A
JA
D000200:Action Potentials / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002490:Central Nervous System / Q000502:physiology* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000503:physiopathology*; D005260:Female; D005385:Fingers / Q000294:innervation; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D009132:Muscles / Q000294:innervation; D013997:Time Factors