The coalescent process in models with selection, recombination and geographic subdivision.
A population genetic model with a single locus at which balancing selection acts and many linked loci at which neutral mutations can occur is analysed using the coalescent approach. The model incorporates geographic subdivision with migration, as well as mutation, recombination, and genetic drift of neutral variation. It is found that geographic subdivision can affect genetic variation even with high rates of migration, providing that selection is strong enough to maintain different allele frequencies at the selected locus. Published sequence data from the alcohol dehydrogenase locus of Drosophila melanogaster are found to fit the proposed model slightly better than a similar model without subdivision.
Kaplan
N
N
National Institute of Environmental Health Sciences, Research Triangle Park, N.C. 27709.
Hudson
R R
RR
Iizuka
M
M
D000426:Alcohol Dehydrogenase / Q000235:genetics; D000818:Animals; D004331:Drosophila melanogaster / Q000201:enzymology / Q000235:genetics*; D005787:Gene Frequency; D008433:Mathematics; D008957:Models, Genetic; D009154:Mutation; D011995:Recombination, Genetic; D012641:Selection, Genetic
D000426:Alcohol Dehydrogenase