The role of calcitonin gene-related peptide in gastric mucosal protection in the rat.
The presence of circulating antibodies to calcitonin gene-related peptide (CGRP) enhanced the damaging effect of ethanol on the rat gastric mucosa. Taken together with previous experimental and morphological data the results suggest that CGRP released from the peripheral terminals of visceral afferent fibres plays a role in mediating gastric mucosal defence mechanisms.
Forster
E R
ER
Department of Physiology, University of Liverpool.
Dockray
G J
GJ
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D000917:Antibody Formation; D015740:Calcitonin Gene-Related Peptide / Q000008:administration & dosage / Q000502:physiology*; D000431:Ethanol; D005753:Gastric Mucosa / Q000276:immunology*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D013272:Stomach Diseases / Q000139:chemically induced / Q000276:immunology
D000431:Ethanol; D015740:Calcitonin Gene-Related Peptide