Familial nonmedullary thyroid cancer.
A 5-fold excess risk of nonmedullary thyroid cancer among close relatives of affected patients was detected in a population-based case-control study of thyroid cancer in Connecticut. The 2 familial cases with early onset and multiple foci suggest genetic susceptibility, whereas the 2 cases with late onset may be related to a common environmental exposure.
Ron
E
E
Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health, Bethesda, Md.
Kleinerman
R A
RA
LiVolsi
V A
VA
Fraumeni
J F
JF
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D003237:Connecticut; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology