The effects of intravenous clonidine on ventilation.
The effects of clonidine, an alpha 2 adrenergic agonist, on ventilation were studied in a group of adult volunteers. The ventilatory variables measured were minute ventilation, respiratory rate, end-tidal carbon dioxide tension and the response to carbon dioxide challenge. We found no differences in minute ventilation, respiratory rate and end-tidal carbon dioxide tension, before and after clonidine administration. However, the ventilatory response to carbon dioxide was significantly attenuated following clonidine, suggesting that clonidine has respiratory depressant effects.
Ooi
R
R
Magill Department of Anaesthetics, Westminster Hospital, London.
Pattison
J
J
Feldman
S A
SA
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D003864:Depression, Chemical; D004341:Drug Evaluation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D012119:Respiration / Q000187:drug effects*
D002245:Carbon Dioxide; D003000:Clonidine