Inhibitory effect of phosphatidylserine on iron-dependent lipid peroxidation.
The effect of phospholipids on lipid peroxidation was investigated in liposomal suspension of egg yolk phosphatidylcholine. Both saturated and unsaturated phosphatidylserine effectively inhibited lipid peroxidation induced by ferrous-ascorbate system in the presence of phosphatidylcholine hydroperoxides. Studies on the iron trapping effect of phospholipids indicated that the effectiveness of inhibition depends on the charge of phosphatidylserine that binds to free ionic iron.
Yoshida
K
K
Department of Food Science and Technology, Faculty of Fisheries, Hokkaido University, Japan.
Terao
J
J
Suzuki
T
T
Takama
K
K
D000578:Amidines / Q000494:pharmacology; D000818:Animals; D004527:Egg Proteins / Q000737:chemistry; D005609:Free Radicals; D007501:Iron / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes; D010713:Phosphatidylcholines / Q000737:chemistry; D010718:Phosphatidylserines / Q000494:pharmacology*
D000578:Amidines; D004527:Egg Proteins; D005609:Free Radicals; D008081:Liposomes; D010713:Phosphatidylcholines; D010718:Phosphatidylserines; C046728:2,2'-azobis(2-amidinopropane); D007501:Iron