Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?
Alzheimer's disease is characterized by the presence of amyloid plaques in the brain, which comprise mainly beta-amyloid peptide and alpha 1-antichymotrypsin. Here, Peter Vandenabeele and Walter Fiers advance the hypothesis that this amyloidogenesis results from an IL-1-/IL-6-mediated acute phase reaction in the brain. They propose possible intracerebral sources of cytokines and acute phase proteins in microglia, astrocytes, neurons and cells of the choroid plexus.
Vandenabeele
P
P
Laboratory of Molecular Biology, State University, Gent, Belgium.
Fiers
W
W
D000210:Acute-Phase Reaction / Q000209:etiology; D000544:Alzheimer Disease / Q000150:complications* / Q000276:immunology; D000686:Amyloidosis / Q000209:etiology* / Q000276:immunology; D001921:Brain / Q000276:immunology; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D008954:Models, Biological
D007375:Interleukin-1; D015850:Interleukin-6