[Anti-BHc determination in blood donors in São Paulo: should this test be adopted in Brazil?].
OBJECTIVE
to study the incidence of anti-HBc (core) as a surrogate marker for post-transfusion Non-A, Non-B Hepatitis (HNANB-PT) among blood donors in São Paulo, Brazil. TYPE: prospective, screening all blood donors from September to December, 1989 (nr. 2,773 donors).


METHODS
Sírio-Libanês Hospital and 9 de Julho Hospital (São Paulo).


METHODS
a total of 2,773 donors, 84% male and 16% female.


METHODS
the tests used were competitive ELISA for Anti-HBc.


RESULTS
the repeated rah reactivity (RR) was 10.2% among all donors, with a higher incidence in males than in females (10.9% x 6.8% p less than 0.05 6y X2). Only 4.5% were borderlines, and 94.5% showed an absorbance/cut-off ratio less than 0.9.


CONCLUSIONS
despite the lack of prospective studies correlating HNANB-PT to surrogate markers (e.g. ALT and anti-HBc) in this country, the high incidence of anti-HBc in donors allows to conclude that it might be as high as reported in other countries. Although the costs related to the adoption of this test, its indication in other countries and its association with the newly-developed specific test (anti-HCV) supports the idea of anti-HBc as a screening test for HNANB-PT in Brazil, at least in the most developed blood centers in the country.
Wendel
S
S
Bancos de Sangue, Hospitais Sírio-Libanês, São Paulo.
Luzzi
J R
JR
Russo
C
C
de Cássia
R
R
Fontão
L
L
Ghaname
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001782:Blood Donors; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006526:Hepatitis C / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D065227:Transfusion Reaction
D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens
Pesquisa de anti-HBc em doadores de sangue em São Paulo: deverá esse teste ser adotado pelo Brasil?