Brain lesions following combined treatment with methotrexate and craniospinal irradiation.
Eight patients with meningeal seeding by carcinoma or lymphomas were treated with intravenous (i.v.) and/or intrathecal (i.th.) Methotrexate (MTX). Seven patients received additional craniospinal irradiation and in all seven a fatal encephalopathy developed. On the bases of clinical and morphological findings we identified an acute and a delayed form of encephalopathy and concluded that the concurrent administration of Methotrexate and of craniospinal irradiation increases considerably the risk of brain damage.
Cruz-Sanchez
F F
FF
Neurological Tissue Bank, Hospital Clinico I Provincial, University of Barcelona.
Artigas
J
J
Cervos-Navarro
J
J
Rossi
M L
ML
Ferszt
R
R
D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology; D001929:Brain Edema / Q000139:chemically induced; D001943:Breast Neoplasms / Q000188:drug therapy / Q000628:therapy; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000009:adverse effects; D003711:Demyelinating Diseases; D003937:Diagnosis, Differential; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D008223:Lymphoma / Q000188:drug therapy / Q000628:therapy; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D001523:Mental Disorders / Q000175:diagnosis; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009336:Necrosis
D008727:Methotrexate