A comparison of iohexol and diatrizoate-meglumine in children undergoing cardiac catheterization.
Iohexol (Omnipaque) and meglumine and sodium diatrizoate (Renografin-76) were compared in a double-blind, randomized study for their efficacy, safety, and hemodynamic effects as angiographic contrast agents in children. Forty-four children were randomly allocated to receive either iohexol or diatrizoate as a component of their routine or emergency cardiovascular evaluation. Following age stratification, baseline physiologic parameters were not significantly different between patients receiving either iohexol or diatrizoate. After systemic ventricular injection, iohexol produced significantly less hemodynamic alteration in systemic systolic blood pressure, systemic ventricular end-diastolic pressure, and dP/dt. Less alteration in heart rate and significantly less effect on the QT interval were seen with iohexol. Image quality was comparable, although significantly more patient mobility was associated with diatrizoate-meglumine. This study shows that iohexol, a nonionic contrast medium, causes less hemodynamic disturbance than diatrizoate-meglumine in children. Therefore, its use to be preferred in these potentially high-risk patients.
Pelech
A N
AN
Variety Children's Heart Centre, University of Manitoba, Winnipeg, Canada.
Allard
S M
SM
Hurd
R T
RT
Giddins
N G
NG
Collins
G F
GF
D000293:Adolescent; D000790:Angiocardiography / Q000379:methods / Q000592:standards; D006328:Cardiac Catheterization / Q000379:methods / Q000592:standards; D002648:Child; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007472:Iohexol / Q000009:adverse effects; D011856:Radiographic Image Enhancement; D013997:Time Factors
D003974:Diatrizoate Meglumine; D007472:Iohexol