title: Phenotyping of immunocompetent cells in normal labial and palatal salivary glands and in non-autoimmune sialadenitis.
abstract: Different types of inflammatory cells in healthy major and minor salivary glands (SG), including those in labial and palatal non-autoimmune sialadenitis, were quantified immunohistochemically. Plasma cells, mainly IgA type predominated in all SG types, with the smallest number seen in the palatal glands. The numbers of common leukocyte antigen (CLA) reactive lymphocytes were greater in major SGs than in minor ones and were predominantly UCHL1 positive T cell type. Macrophages and neutrophils were absent in palatal glands, rarely present in labial ones and usually present in major SGs. Increases in the number of IgG and IgM plasma cells and lymphocytes (CLA+) which include both UCHL1+ T and L26+ B cell types, were found in non-autoimmune labial and palatal sialadenitis. There was no significant correlation between the number of the inflammatory cells and the degree of glandular atrophy in both labial and palatal non-autoimmune sialadenitis. Increase in their number represents a protective response of these glands in contrast to the inflammatory cells in major autoimmune sialadenitis playing there a pathogenetic role.
authors.affiliation: Department of Dermatology, University of Erlangen-Nürnberg, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Vigneswaran
authors.forename: K P
authors.initials: KP
authors.lastname: Peters
authors.forename: T L
authors.initials: TL
authors.lastname: Diepgen
authors.forename: C
authors.initials: C
authors.lastname: Wahlich
authors.forename: O P
authors.initials: OP
authors.lastname: Hornstein
authors.forename: E
authors.initials: E
authors.lastname: Haneke
mesh_terms: D000943:Antigens, Differentiation; D001284:Atrophy; D001327:Autoimmune Diseases; D001402:B-Lymphocytes / Q000166:cytology* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008046:Lip; D008264:Macrophages / Q000166:cytology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology / Q000473:pathology; D010159:Palate; D010306:Parotid Gland / Q000166:cytology / Q000473:pathology; D010641:Phenotype; D010950:Plasma Cells / Q000166:cytology / Q000473:pathology; D012469:Salivary Glands / Q000166:cytology* / Q000473:pathology; D012793:Sialadenitis / Q000473:pathology*; D013363:Submandibular Gland / Q000166:cytology / Q000473:pathology; D013601:T-Lymphocytes / Q000166:cytology* / Q000473:pathology
chemical_list: D000943:Antigens, Differentiation