Fever produced by intrahypothalamic injection of interleukin-1 and interleukin-6.
Pure human interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6), both of natural origin, were found to cause fever in rabbits when injected into the PO/AH region of the brain. The threshold dose required for this effect was between 0.4 and 4 U, equivalent to 0.04 to 0.4 ng for IL-1 beta, and around 50 U, equivalent to 0.05 ng for IL-6. From this it was estimated that this area of the brain responds to a local concentration of approximately 1 ng/ml of these cytokines, a level which can easily be reached after intravenous administration of threshold pyrogenic doses of either cytokine. The observation supports the view that fever induced by systemic endogenous production of IL-1 and IL-6 is due to a direct effect on the thermoregulatory center and may not require production of mediators, such as prostaglandins, at sites distant from the center.
Lesnikov
V A
VA
Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad.
Efremov
O M
OM
Korneva
E A
EA
Van Damme
J
J
Billiau
A
A
D000818:Animals; D001833:Body Temperature Regulation; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli; D005334:Fever / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D007275:Injections, Intravenous; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D015850:Interleukin-6 / Q000008:administration & dosage / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008297:Male; D008845:Microinjections; D011817:Rabbits; D013238:Stereotaxic Techniques
D007375:Interleukin-1; D015850:Interleukin-6; D008070:Lipopolysaccharides