Spectrophotometric methods for the determination of sulphathiourea.
Three simple and sensitive spectrophotometric methods are described for the determination of sulphathiourea. The methods are based on the interaction of this thioamide with either iodine, tetracyanoethylene (TCNE) or copper nitrate to give the corresponding charge-transfer or metal-ion complexes, which can be measured at 363, 350 and 353 nm, respectively. In each case, a 1:1 complex was formed. Beer's law is obeyed for each procedure in a concentration range of 1-150 micrograms ml-1. The proposed procedures can be applied to the determination of sulphathiourea in its pharmaceutical formulations.
Askal
H F
HF
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Egypt.
Saleh
G A
GA
D013053:Spectrophotometry / Q000379:methods; D013424:Sulfanilamides / Q000032:analysis*
D013424:Sulfanilamides; C025270:sulfathiourea