Myelodysplastic syndrome and pancytopenia in a patient with non-A, non-B chronic active hepatitis.
Non-A, non-B viral hepatitis may cause many different hematologic abnormalities, such as transient anemia, granulocytopenia, thrombocytopenia, atypical lymphcytosis, or aplastic anemia. We describe a patient who developed a myelodysplastic syndrome (refractory anemia with excess blasts) after prednisone therapy for non-A, non-B chronic active hepatitis. We discuss the effects of non-A, non-B viral infection on the bone marrow and potential explanations for the previously unreported association with myelodysplastic syndrome.
Jacoby
R F
RF
Department of Medicine, University of Chicago, Illinois.
Brasitus
T A
TA
D000368:Aged; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy; D006521:Hepatitis, Chronic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000209:etiology*; D010198:Pancytopenia / Q000209:etiology*; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use
D011241:Prednisone