Results of endoscopic variceal sclerotherapy: influence of etiology of portal hypertension and hepatic functional status.
In India 50% of patients with gastrointestinal bleeding bleed from esophageal varices. Causes of portal hypertension includes hepatic cirrhosis, non-cirrhotic portal fibrosis and extrahepatic portal obstruction. Endoscopic sclerotherapy is the treatment of choice to control continued active bleeding. Immediate hemostasis was not influenced by the etiology of portal hypertension. However, rebleeding episodes were lower, in extrahepatic portal vein obstruction than non-cirrhotic portal fibrosis and cirrhotic patients. Child's status significantly influenced recurrence of bleeding and mortality which was lower in child's A than B and lower in B than C irrespective of etiology. Results of long term sclerotherapy were also influenced by the etiology of portal hypertension and hepatic functional status. Sclerotherapy was most effective in patients of (EHO), than (NCPF) followed by cirrhosis of the liver.
Bhargava
D K
DK
Department of Gastroenterology & Biostatistics, All India Institute of Medical Sciences, New Delhi.
Dasarathy
S
S
Sundaram
K R
KR
Ahuja
R K
RK
D016009:Chi-Square Distribution; D016145:Endoscopy, Digestive System; D004932:Esophageal and Gastric Varices / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000209:etiology* / Q000503:physiopathology; D007194:India; D008099:Liver / Q000503:physiopathology; D015911:Sclerotherapy; D016019:Survival Analysis