[Effects of bromadiolone on some organs and tissues (liver, kidney, spleen, blood) of coypu (Myocastor coypus)].
Bromadiolone damaged the erythrocytes, resulting in a probable saturation of transferrin, a deposit of iron in the connective tissue and in a few cells of the proximal tubules of the kidneys and an increased storage of ferritin in the spleen. In the hepatocytes, mitochondria were distorted, their lipid inclusions being granular; a large depletion of glycogen may be considered a reflection of an elevated phosphorylase a ascribable to the proliferation of the smooth endoplasmic reticulum. In the kidneys, pyelonephritis may be irrelevant to the poisoning of the animals. Bromine could not be detected using microanalytical methods.
Jeantet
A Y
AY
Laboratoire d'Histophysiologie fondamentale et appliquée, Université Paris-VI.
Truchet
M
M
Naulleau
G
G
Martoja
R
R
D015110:4-Hydroxycoumarins / Q000494:pharmacology*; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D004906:Erythrocyte Count / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D012377:Rodentia; D013154:Spleen / Q000166:cytology / Q000187:drug effects*
D015110:4-Hydroxycoumarins; D000925:Anticoagulants; C021636:bromadiolone
Effets de la bromadiolone sur queleques organes ou tissus (foie, rein, rate, sang) de ragondin (Myocastor coypus).