Stereoselectivity of idarubicin reduction in various animal species and humans.
1. The (13S)-dihydro derivative of idarubicin, (13S)-idarubicinol, is the major urinary metabolite of idarubicin in humans. Idarubicinol epimers were quantified by h.p.l.c. in urine from rats, mice, rabbits, dogs and man after i.v. administration of idarubicin, and in man after oral dosing. The (13R)- and (13S)-epimers of idarubicinol were determined in rat bile. 2. After i.v. injection of idarubicin. (13R)-idarubicinol was not detectable in mice and rabbit urine and no more than 0.5% of the dose was present in the urine of other species. In man, the proportion of (13R)-idarubicinol in total idarubicinol was similar after i.v. (4.1%) and oral (3.8-5.0%) administration of idarubicin; the same applies to rat bile and urine. 3. Reduction of idarubicin in vivo is dependent upon ketone reductases, and proceeds more stereoselectively than that of most ketones giving rise to the (13S)-epimer almost exclusively. The high stereospecificity in idarubicin reduction might result from chiral induction due to the presence of asymmetric centres near to the carbonyl group in idarubicin.
Strolin Benedetti
M
M
Farmitalia Carlo Erba, Research and Development--Erbamont Group, Milan, Italy.
Pianezzola
E
E
Fraier
D
D
Castelli
M G
MG
Dostert
P
P
D000284:Administration, Oral; D000368:Aged; D000818:Animals; D001646:Bile / Q000378:metabolism; D004285:Dogs; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000737:chemistry / Q000378:metabolism* / Q000652:urine; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008875:Middle Aged; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D015255:Idarubicin