Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.
We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL-10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth when combined with IL-3 or IL-4. Moreover, IL-4 plus IL-10 supported the proliferation of mast cells as well as IL-3, suggesting that these two factors may provide a pathway for their development independent of IL-3. However, optimal mast cell growth was stimulated by the combination of IL-10, IL-4, and IL-3. This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses.
Thompson-Snipes
L
L
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304.
Dhar
V
V
Bond
M W
MW
Mosmann
T R
TR
Moore
K W
KW
Rennick
D M
DM
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D016753:Interleukin-10; D007377:Interleukin-3 / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D007378:Interleukins / Q000502:physiology*; D008407:Mast Cells / Q000166:cytology* / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins
D007377:Interleukin-3; D007378:Interleukins; D011994:Recombinant Proteins; D016753:Interleukin-10; D015847:Interleukin-4