title: Assays for lupus anticoagulant: the sensitivity of different assays.
abstract: Fifty patients with systemic lupus erythematosus were studied for the presence of lupus anticoagulant using three different assays--kaolin clotting time, platelet neutralization test, and tissue thromboplastin inhibition test. Lupus anticoagulant could be detected in seven cases (14%) with the use of one test in cases with a partial prothrombin time with kaolin more than five seconds greater than normal. The detection rate rose to 20% (10 cases) when using all three tests, so a panel of three assays could identify lupus patients apparently at risk for thrombotic complications.
authors.affiliation: Department of Haematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: A
authors.initials: A
authors.lastname: Jain
authors.forename: S
authors.initials: S
authors.lastname: Dash
authors.forename: N
authors.initials: N
authors.lastname: Marwaha
authors.forename: S D
authors.initials: SD
authors.lastname: Deodhar
authors.forename: S
authors.initials: S
authors.lastname: Sehgal
mesh_terms: D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology*; D001780:Blood Coagulation Tests; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000097:blood*
chemical_list: D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor