Effect of fleroxacin and ciprofloxacin on the formation of human mature colonies of healthy donor versus transplanted hemopoietic progenitor cells.
The effect of fleroxacin and ciprofloxacin on hemopoietic progenitor cells was tested in vitro. Cryopreserved bone marrow samples from 5 patients with acute myeloid leukemia who underwent bone marrow transplantation as well as samples from the respective donors were investigated in parallel. Regarding burst and/or colony formation by erythroid, neutrophil and macrophage precursors, no significant differences were detected with donor and transplanted bone marrows between control cultures and cultures containing 100 mg/l fleroxacin, while 100 mg/l ciprofloxacin inhibited cell proliferation completely. At 50 and 10 mg/l ciprofloxacin had a 50% and no inhibitory effect, respectively.
Kissling
M
M
Pharma Clinical Research, F. Hoffmann-La Roche Ltd. Basel, Switzerland.
Herzog
C
C
Speck
B
B
D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003114:Colony-Forming Units Assay; D016576:Fleroxacin; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans
D002939:Ciprofloxacin; D016576:Fleroxacin