Recurrent haemolytic uraemic syndrome in a transplant recipient on orthoclone (OKT 3).
Recurrence of haemolytic-uraemic syndrome (HUS) after renal transplantation may occur in both cyclosporin A (CyA) and non-CyA-treated patients, and in patients receiving anti-lymphocyte globulin. We report a case of recurrent HUS in an 8-year-old boy who received Orthoclone (OKT3) combined with prednisolone and azathioprine therapy on receipt of his first cadaveric renal allograft. Despite avoidance of CyA therapy irreversible HUS occurred.
Goodman
D J
DJ
Department of Nephrology, Royal Melbourne Hospital, Victoria, Australia.
Walker
R G
RG
Birchall
I E
IE
d'Apice
A J
AJ
Powell
H R
HR
Kincaid-Smith
P
P
D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D001379:Azathioprine / Q000009:adverse effects; D002648:Child; D004359:Drug Therapy, Combination; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced*; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008297:Male; D016853:Muromonab-CD3; D011239:Prednisolone / Q000009:adverse effects; D012008:Recurrence
D000911:Antibodies, Monoclonal; D016853:Muromonab-CD3; D011239:Prednisolone; D001379:Azathioprine