The effect of hyaluronic acid on cartilage in the immobilized rabbit knee.
Out of 30 adult rabbits, 20 had one knee immobilized with a plaster of Paris cast for 6 or 12 weeks, and 10 rabbits were used as untreated controls. Prior to immobilization, 10 knees were injected with high-molecular weight hyaluronic acid. The articular cartilage of the femoral condyles was studied by light microscopy, whereas that of the patella and tibia was analyzed biochemically. Degenerative changes of the articular cartilage similar to those seen in arthrosis were observed after 6 weeks. The intraarticular injection of hyaluronic acid did not prevent these changes; instead, the reparative processes seemed inhibited.
Olsen
E B
EB
Department of Orthopedics, Odense Hospital, Copenhagen, Denmark.
Trier
K
K
Jørgensen
B
B
Brok
K E
KE
Ammitzbøll
T
T
D000818:Animals; D001168:Arthritis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D002358:Cartilage, Articular / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D002809:Chondroitin Sulfates / Q000737:chemistry; D003871:Dermatan Sulfate / Q000737:chemistry; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007103:Immobilization / Q000009:adverse effects*; D007270:Injections, Intra-Articular; D007632:Keratan Sulfate / Q000737:chemistry; D007719:Knee Joint; D011817:Rabbits; D014574:Uronic Acids / Q000737:chemistry
D014574:Uronic Acids; D003871:Dermatan Sulfate; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates; D007632:Keratan Sulfate