Extracellular pH in the brain during ischemia: relationship to the severity of lactic acidosis.
On the basis of data showing a bimodal distribution of values for extracellular pH (pHe), and a discontinuous delta PCO2/delta lactate relationship, Kraig et al. (1986) proposed that H+ is grossly compartmentalized between neurons and glia in the ischemic brain. We measured delta pHe during ischemia, varying ischemic lactate contents between 9 and 38 mmol kg-1. No bimodal distribution was found, but delta pHe varied linearly with lactate content. Because we have also failed to record a discontinuous delta PCO2/delta lactate relationship, we conclude that major compartmentation of H+ does not occur during ischemia.
Katsura
K
K
Laboratory for Experimental Brain Research, University of Lund, Sweden.
Ekholm
A
A
Asplund
B
B
Siesjö
B K
BK
D000140:Acidosis, Lactic / Q000150:complications / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006943:Hyperglycemia / Q000150:complications / Q000378:metabolism; D002546:Ischemic Attack, Transient / Q000150:complications / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid