A miniature Clark-type oxygen electrode using a polyelectrolyte and its application as a glucose sensor.
A miniature Clark-type oxygen electrode was fabricated by anisotropically etching silicon. A two-gold-electrode configuration was used and a double-layered gas-permeable membrane was formed directly on the electrolyte, poly(vinyl-4-ethylpyridinium bromide) in the sensitive area. These materials improved the electrode's stability in long-term storage and sterilization tolerance to a practical level. The 90% response time averaged 80 s and residual current 10%, with a good linear calibration curve. The oxygen electrode was also used to make an integrated sensor for the simultaneous determination of glucose and oxygen. The glucose sensor's response time was 50-110 s, with good linearity in glucose concentrations between 56 microM and 1.1 mM at 37 degrees C, pH 7.0.
Suzuki
H
H
Fujitsu Laboratories Ltd., Atsugi, Japan.
Sugama
A
A
Kojima
N
N
Takei
F
F
Ikegami
K
K
D015374:Biosensing Techniques; D004573:Electrolytes; D004582:Electronics, Medical; D005069:Evaluation Studies as Topic; D005947:Glucose / Q000032:analysis*; D011145:Polyvinyls
D004573:Electrolytes; D011145:Polyvinyls; C027968:poly-4-vinyl-N-ethylpyridine; D005947:Glucose