title: Reversible lactose malabsorption and intolerance in Graves' disease.
abstract: Ten patients with untreated Graves' disease underwent tests to determine lactose absorption, liquid gastric emptying, and oral cecal transit time. To determine the influence of thyroid hormone status on lactose absorption, eight of these same patients had repeat studies when rendered euthyroid. Two of these eight patients also underwent studies while transiently hypothyroid. Motility studies were also evaluated in a group of 11 control subjects. Lactose malabsorption occurred in nine patients with Graves' disease. In seven patients who repeated these studies, lactose malabsorption normalized in three, symptoms induced by lactose improved in two and were unchanged in two. However, these latter two patients appeared to have improved symptoms in the transient hypothyroid state. Liquid gastric emptying was significantly faster in untreated patients than controls and treated self-same patients. Transit time was significantly faster in untreated patients than when they were rendered euthyroid. There may be a relationship between altered lactose absorption states and changes in intestinal motility in patients with Graves' disease.
authors.affiliation: Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec.
authors.forename: A
authors.initials: A
authors.lastname: Szilagyi
authors.forename: S
authors.initials: S
authors.lastname: Lerman
authors.forename: R G
authors.initials: RG
authors.lastname: Barr
authors.forename: J
authors.initials: J
authors.lastname: Stern
authors.forename: A
authors.initials: A
authors.lastname: Colacone
authors.forename: S
authors.initials: S
authors.lastname: McMullan
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005746:Gastric Emptying; D005769:Gastrointestinal Motility; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007787:Lactose Intolerance / Q000209:etiology*; D008297:Male; D008875:Middle Aged