Effects of verapamil and diltiazem on gastric emptying in normal subjects.
It has been suggested that calcium-channel blockers may delay gastric emptying by inhibiting gastric smooth muscle contraction. Most reports in man, however, reveal no significant delay in gastric emptying after using nifedipine; other calcium-channel blockers have not been studied in humans to date. We studied the effects of verapamil and diltiazem on solid-phase gastric emptying in 10 healthy volunteers. Each subject underwent a radionuclide gastric emptying determination (1) without preadministered medication, (2) after verapamil 80 mg orally every 6 hr for 10 doses, and (3) after diltiazem 60 mg by mouth given as one dose. Results revealed no significant difference in gastric emptying rates after pretreatment with verapamil or diltiazem when compared with no premedication (P greater than 0.37). We conclude that verapamil and diltiazem do not significantly delay gastric emptying in normal subjects. These data may be of clinical significance when prescribing calcium-channel blockers to patients with diseases associated with altered gastric emptying.
Yavorski
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RT
Department of Gastroenterology, Fitzsimons Army Medical Center, Aurora, Colorado 80045-5001.
Hallgren
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SE
Blue
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PW
D000328:Adult; D004110:Diltiazem / Q000494:pharmacology*; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D013270:Stomach / Q000000981:diagnostic imaging; D013671:Technetium Tc 99m Sulfur Colloid; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology*
D013671:Technetium Tc 99m Sulfur Colloid; D014700:Verapamil; D004110:Diltiazem