[ADP ribosylation of actin--a cytotoxic principle of bacterial toxins].
The ADP-ribosylation of actin is the pathobiochemical mechanism by which various clostridial toxins affect the eukaryotic target cell. The toxins are binary in structure and consist of a binding component and an enzyme component with ADP-ribosyltransferase activity. Probably endocytosis-mediated the binding component transfers the clostridial ADP-ribosyltransferase into the target cell, whereupon G-actin but not F-actin is ADP-ribosylated. The ADP-ribosylated actin is incapable of polymerization but binds to the barbed ends of actin filaments to inhibit polymerization of non-modified actin. Thereby the ADP-ribosylation of actin destroys the cellular architecture of the microfilament network. The ADP-ribosylating toxins are novel tools to study the physiological functions of actin.
Just
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Universitätsklinikum Essen, Institut für Pharmakologie.
Aktories
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D000199:Actins / Q000378:metabolism*; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D001427:Bacterial Toxins / Q000378:metabolism*; D003013:Clostridium; D006801:Humans; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*
D000199:Actins; D001427:Bacterial Toxins; D000246:Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases
ADP-Ribosylierung von Aktin--ein zytotoxisches Prinzip bakteriellerToxine.