Bisfuranoid mycotoxins: their genotoxicity and carcinogenicity.
Based on the mode of action of AFB1 and the activities of its biologically active intermediates, one may conclude that: 1. The mode of toxic action of the bisfuranoid mycotoxin is through epoxidation of the vinyl ether double bond of their dihydrobisfuran functionality. 2. The DNA and plasma albumin adducts formed in vivo may be useful in the molecular dosimetry of these environmental carcinogens. 3. There appears to be a linear correlation between the steady state levels of AFB1-FAPy-DNA adducts and the carcinogenicity of AFB1. Elucidation of the molecular basis of this correlation may shed light on the mechanism of AFB1-induced carcinogenesis. 4. Consistent appearance of AFB1-DNA adducts in the livers of liver cancer patients tested is supportive of the IARC conclusion that AFB1 is a human carcinogen involved in human primary liver cancer.
Hsieh
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DP
Department of Environmental Toxicology, University of California, Davis 95616.
Atkinson
D N
DN
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D009153:Mutagens; D009183:Mycotoxins / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity*; D013241:Sterigmatocystin / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity
D000348:Aflatoxins; D002273:Carcinogens; D009153:Mutagens; D009183:Mycotoxins; D013241:Sterigmatocystin; D004247:DNA; D016604:Aflatoxin B1