title: Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I.
abstract: Human T cell leukemia virus type-I (HTLV-I) is the etiologic agent of adult T cell leukemia and has also been suggested to be involved in other diseases such as chronic arthritis or myelopathy. To elucidate pathological roles of the virus in disease, transgenic mice were produced that carry the HTLV-I genome. At 2 to 3 months of age, many of the mice developed chronic arthritis resembling rheumatoid arthritis. Synovial and periarticular inflammation with articular erosion caused by invasion of granulation tissues were marked. These observations suggest a possibility that HTLV-I is one of the etiologic agents of chronic arthritis in humans.
authors.affiliation: Institute of Medical Science, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iwakura
authors.forename: M
authors.initials: M
authors.lastname: Tosu
authors.forename: E
authors.initials: E
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Takiguchi
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: I
authors.initials: I
authors.lastname: Kitajima
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Hatanaka
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D005814:Genes, Viral; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D007249:Inflammation; D007596:Joints / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D012333:RNA, Messenger / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D014759:Viral Envelope Proteins / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D014759:Viral Envelope Proteins