title: Translocation (14;19) in acute biphenotypic leukemia.
abstract: Translocation (14;19)(q32;q13.1) is an acquired chromosomal rearrangement that has been associated with chronic lymphocytic leukemia of B-cell phenotype frequently progressing to lymphoma. Molecular analysis suggests that the translocation involves the immunoglobulin heavy chain gene on chromosome 14 and the BCL3 oncogene on chromosome 19. We present the first case of t(14;19) in a patient with acute leukemia. Correlation of detailed cytogenetic and molecular genetic studies, cell surface marker analysis, cytochemistry, and electron microscopy indicated that the leukemic cells were biophenotypic, with characteristics consistent with both myeloid and B-lineage lymphoid differentiation.
authors.affiliation: University of Toronto Hospitals Cancer Cytogenetics Program, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Carter
authors.forename: I
authors.initials: I
authors.lastname: Dubé
authors.forename: T
authors.initials: T
authors.lastname: McKeithan
authors.forename: K
authors.initials: K
authors.lastname: Carstairs
authors.forename: E
authors.initials: E
authors.lastname: DeHarven
authors.forename: D
authors.initials: D
authors.lastname: Bailey
authors.forename: J G
authors.initials: JG
authors.lastname: Scott
mesh_terms: D000328:Adult; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D002883:Chromosomes, Human, Pair 14; D002888:Chromosomes, Human, Pair 19; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008854:Microscopy, Electron; D014178:Translocation, Genetic
chemical_list: D007143:Immunoglobulin Heavy Chains