Pregnancy rates after timed intercourse or intrauterine insemination after human menopausal gonadotropin stimulation of normal ovulatory cycles: a controlled study.
Forty-eight patients with male (n = 16) or idiopathic (n = 32) infertility were stimulated with human menopausal gonadotropin. Intrauterine insemination (IUI) or natural intercourse were performed after either human chorionic gonadotropin (hCG)-induced or spontaneous, urinary luteinizing hormone (LH) surge-monitored ovulation. A total of 148 cycles were analyzed. In 40 cycles treated with hCG-induced ovulation and IUI, 3 (7.5%) patients conceived, whereas 37 women accomplished natural intercourse after hCG-induced ovulation and 2 (5.5%) became pregnant. When inseminated after a spontaneous LH surge, 3 (8.8%) of 34 patients achieved a pregnancy; no conception occurred in 37 spontaneously ovulatory cycles combined with timed intercourse. Pregnancy rates did not substantially differ between the treatment modalities or between mono-ovulatory and polyovulatory cycles. The cycle characteristics between spontaneous ovulatory and hCG-induced cycles significantly did differ.
Martinez
A R
AR
Department of Obstetrics and Gynecology, Free University Hospital, Amsterdam, The Netherlands.
Bernardus
R E
RE
Voorhorst
F J
FJ
Vermeiden
J P
JP
Schoemaker
J
J
D006063:Chorionic Gonadotropin; D003075:Coitus; D005260:Female; D006801:Humans; D007317:Insemination, Artificial, Homologous; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D011258:Pregnancy Tests
D006063:Chorionic Gonadotropin; D008596:Menotropins; D007986:Luteinizing Hormone