title: Sodium lithium countertransport is acutely influenced by heparin-induced extracorporal LDL precipitation.
abstract: Sodium lithium countertransport may be a genetic marker for arterial hypertension and for the risk of diabetic nephropathy in type 1 diabetic patients. Since various factors seem to influence the transport velocity including serum lipid alterations, erythrocytes of seven patients with severe hyperlipoproteinaemia who were chronically and intermittently treated with LDL apheresis were examined before and immediately after therapy. The LDL apheresis reduced sodium lithium countertransport significantly (0.383 vs 0.269, P less than 0.02). Therefore, we conclude that serum lipid composition must be considered when interpreting sodium lithium countertransport velocity.
authors.affiliation: Ferdinand Sauerbruch Clinic, Medical Clinic of Professor Dr J. Köbberling, Wuppertal, FRG.
authors.forename: H
authors.initials: H
authors.lastname: Messner
authors.forename: W
authors.initials: W
authors.lastname: Kleophas
authors.forename: D
authors.initials: D
authors.lastname: Hein
authors.forename: F A
authors.initials: FA
authors.lastname: Gries
authors.forename: J
authors.initials: J
authors.lastname: Köbberling
mesh_terms: D000328:Adult; D001692:Biological Transport / Q000502:physiology; D001781:Blood Component Removal / Q000379:methods; D002463:Cell Membrane Permeability / Q000502:physiology; D011232:Chemical Precipitation; D004912:Erythrocytes / Q000378:metabolism; D006493:Heparin; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000628:therapy; D008077:Lipoproteins, LDL / Q000097:blood*; D008094:Lithium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood*
chemical_list: D008077:Lipoproteins, LDL; D006493:Heparin; D008094:Lithium; D012964:Sodium