Quinine-induced tinnitus in rats.
Quinine ingestion reportedly induces tinnitus in humans. To expand our salicylate-based animal model of tinnitus, a series of conditioned suppression experiments was performed on 54 male-pigmented rats using quinine injections to induce tinnitus. Quinine induced changes in both the extent of suppression and recovery of licking, which followed a pattern that paralleled those produced after salicylate injections, and which may be interpreted as the result of tinnitus perception in animals. These changes depended on the dose and time schedule of quinine administration. Additionally, the calcium channel blocker, nimodipine, abolished the quinine-induced effect in a dose-dependent manner.
Jastreboff
P J
PJ
Department of Surgery, Yale University School of Medicine, New Haven, Conn.
Brennan
J F
JF
Sasaki
C T
CT
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D009553:Nimodipine / Q000494:pharmacology; D011803:Quinine / Q000633:toxicity*; D051381:Rats; D012459:Salicylates / Q000633:toxicity; D014012:Tinnitus / Q000139:chemically induced*
D012459:Salicylates; D009553:Nimodipine; D011803:Quinine