title: Analysis of a variant form of platelet glycoprotein (GP) IIb: a second patient with abnormal molecular weight GPIIb.
abstract: In 1988, we reported a thrombasthenic patient whose platelets contained an abnormal molecular weight GPIIb (Blood, 71, 915, 1988). Here we describe another patient whose platelets contain a variant GPIIb with properties similar to the previously reported abnormal GPIIb. This patient has a small amount of the abnormal GPIIb and was suggested to be a heterozygote characterized by deficient and abnormal GPIIb genes. The abnormal GPIIb was suggested to be related to the precursor form of GPIIb because the molecular weights of both proteins are the same. The abnormal GPIIb may lack a peptide region around the cleavage site of the two chains, as suggested from its lack of reactivity towards antibodies against these epitopes.
authors.affiliation: Department of Protein Biochemistry, Kurume University, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Moroi
authors.forename: J
authors.initials: J
authors.lastname: Yamamura
authors.forename: H
authors.initials: H
authors.lastname: Koga
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
authors.forename: S M
authors.initials: SM
authors.lastname: Jung
mesh_terms: D000911:Antibodies, Monoclonal; D001792:Blood Platelets / Q000737:chemistry; D002460:Cell Line; D002648:Child; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006580:Genetic Carrier Screening; D014644:Genetic Variation; D006801:Humans; D015151:Immunoblotting; D008297:Male; D008970:Molecular Weight; D010980:Platelet Membrane Glycoproteins / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D000911:Antibodies, Monoclonal; D010980:Platelet Membrane Glycoproteins