Increased platelet aggregation after heart transplantation: influence of aspirin.
Accelerated graft coronary artery disease remains the most dramatic complication in long-term survivors of heart transplantation. The main purpose of this study was to evaluate ex vivo platelet function of heart transplant recipients as compared with that of healthy subjects and nontransplant coronary patients. The influence of aspirin, the chief antiplatelet agent, was also evaluated. The heart transplant recipients exhibited a marked platelet hyperaggregation to adenosine diphosphate as compared with the two control groups. In addition, platelets of the heart transplant recipients appeared to be resistant to the inhibitory effect of aspirin. These results could, at least partly, explain the failure of antiplatelet agents to prevent myocardial infarction in these patients.
de Lorgeril
M
M
INSERM Unit 63, Bron, France.
Dureau
G
G
Boissonnat
P
P
Ovize
M
M
Monnez
C
C
Monjaud
I
I
Salen
P
P
Renaud
S
S
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001241:Aspirin / Q000627:therapeutic use*; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*
D000244:Adenosine Diphosphate; D001241:Aspirin