title: Kidney biopsy findings in cyclosporine-treated patients with insulin-dependent diabetes mellitus.
abstract: Renal biopsy specimens of 40 patients with recent-onset insulin-dependent diabetes mellitus treated with cyclosporine (CSA) for 6-29 months were examined. Cyclosporine-associated chronic vascular interstitial toxicity of moderate intensity was found in 10 patients (25%). The most prominent lesions were interstitial fibrosis and tubular atrophy. Arteriolopathy was less pronounced and glomerular damage unremarkable. A significant correlation exists between the extent of tubular atrophy and CSA trough whole blood levels. These data indicate that the development of CSA-associated chronic nephropathy is dose-dependent.
authors.affiliation: Institut für Pathologie, Universität Basel, Switzerland.
authors.forename: M J
authors.initials: MJ
authors.lastname: Mihatsch
authors.forename: U
authors.initials: U
authors.lastname: Helmchen
authors.forename: P
authors.initials: P
authors.lastname: Casanova
authors.forename: R
authors.initials: R
authors.lastname: Habib
authors.forename: S
authors.initials: S
authors.lastname: Larsen
authors.forename: A
authors.initials: A
authors.lastname: Magil
authors.forename: L H
authors.initials: LH
authors.lastname: Noel
authors.forename: J
authors.initials: J
authors.lastname: Rapola
authors.forename: J
authors.initials: J
authors.lastname: Ulrich
authors.forename: A C
authors.initials: AC
authors.lastname: Wallace
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000473:pathology; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000473:pathology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007677:Kidney Function Tests; D008134:Long-Term Care; D008297:Male
chemical_list: D003524:Cyclosporins