[The suppression of cellular Na+/H+ exchange leads to the inhibition of influenza virus activity].
It was shown that amiloride, orthovanade and uabain induced almost a two-fold decrease in the rate of incubation medium oxidation by the chick embryo fibroblasts due to the Na+/H+ exchange and inhibited by more than 95 per cent the influenza virus activity. The following mechanism for inhibition of the influenza virus multiplication in the cells under the effect of the above mentioned substances was proposed: suppression of the cellular Na+/H+ exchange responsible for the decrease in pH value in the virus-carrying endosomes----prevention of the decrease in the intraendosomal pH value to the critical level----blocking of the acid dependent process of the virus uncoating----inhibition of the influenza infection as a whole.
Kirillov
V A
VA
Goreva
L N
LN
Vladyko
G V
GV
Boreko
E I
EI
Rusiaev
V A
VA
Votiakov
V I
VI
D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D002642:Chick Embryo; D003864:Depression, Chemical; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D006859:Hydrogen / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D009975:Orthomyxoviridae / Q000187:drug effects / Q000472:pathogenicity* / Q000502:physiology; D010042:Ouabain / Q000494:pharmacology; D012299:Rimantadine / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*; D014638:Vanadates / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects / Q000502:physiology
D012299:Rimantadine; D014638:Vanadates; D010042:Ouabain; D000584:Amiloride; D006859:Hydrogen; D012964:Sodium
Podavlenie kletochnogo Na+/H+-obmena privodit k ingibirovaniiu aktivnoosti virusa grippa.