Reactive metabolite hypothesis for human senile cataract.
One of the research programs of the Australian Cataract Research Foundation (ACRF) is aimed at investigating the possibility that senile cataract both cortical and nuclear, may result from the interaction of reactive metabolites with proteins in the lens. In particular we are exploring the potential role of tryptophan metabolites for example, 3-hydroxyanthranilic acid, in this disease. This article examines briefly some aspects of this approach.
Truscott
R J
RJ
Australian Cataract Research Foundation, University of Wollongong, NSW.
Pyne
S G
SG
Manthey
M
M
D015095:3-Hydroxyanthranilic Acid / Q000378:metabolism*; D000375:Aging / Q000502:physiology*; D002386:Cataract / Q000378:metabolism*; D003459:Crystallins / Q000378:metabolism*; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism*; D008954:Models, Biological
D003459:Crystallins; D015095:3-Hydroxyanthranilic Acid