title: Analytical goals for interference.
abstract: Objective analytical goals for interference in clinical biochemical methods have not yet been advocated. We propose that, since total analytical error is ideally less than half the within-subject biological coefficient of variation (CVI), the maximum allowable systematic error produced by an interferent (I) is: I less than CVI-(1.96 CVA + SE), where CVA is the relevant experimental analytical imprecision and SE is the systematic error. Such a goal may be applicable also to non-specificity, matrix effects and carryover.
authors.affiliation: Servei de Bioquímica Clínica, Hospital Prínceps d'Espanya, Barcelona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Fuentes-Arderiu
authors.forename: C G
authors.initials: CG
authors.lastname: Fraser
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000592:standards*; D002624:Chemistry, Clinical / Q000592:standards*; D003627:Data Interpretation, Statistical; D005188:False Negative Reactions; D005189:False Positive Reactions; D012680:Sensitivity and Specificity