Influence of an intravenous dose of aurothiomalate on the status of low-molecular-mass endogenous metabolites in blood plasma: a proton nuclear magnetic resonance (NMR) study.
The effect of aurothiomalate on the status of a wide range of low-molecular-mass endogenous metabolites in blood plasma obtained from animals treated with an intravenous dose of this second-line agent (150 mg/kg) has been assessed by high field proton Hahn spin-echo NMR spectroscopy. As well as modulating the effective concentrations of NMR-detectable biomolecules, aurothiomalate induces a time-dependent decrease in plasma levels of triacylglycerols with a corresponding elevation in the concentration of the ketone body 3-D-hydroxybutyrate, indicating an increased utilisation of fats for energy in rats treated with this 1:1 gold(I)-thiolate complex. These observations may reflect the toxic side-effects that are associated with aurothiomalate treatment.
Grootveld
M
M
Inflammation Group, London Hospital Medical College, U.K.
Claxson
A W
AW
Naughton
D
D
Whelan
M
M
Furst
A
A
Blake
D R
DR
D020155:3-Hydroxybutyric Acid; D000818:Animals; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage / Q000494:pharmacology*; D006885:Hydroxybutyrates / Q000097:blood; D007275:Injections, Intravenous; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D006885:Hydroxybutyrates; D014280:Triglycerides; D006052:Gold Sodium Thiomalate; D020155:3-Hydroxybutyric Acid