[Pikamilon pharmacokinetics in animals].
Pycamilon was shown to be rapidly absorbed in the blood (tmax = 0.23 h), to penetrate well through the blood-brain barrier and to be intensively uptaken by the animal organs and tissues and to be eliminated mainly in the urine (t1/2 = 0.51 h). The drug bioavailability at oral administration to mice is 21.9%, and to rats from 53 to 78.9% (according to the urinary excretion data).
Dorofeev
B F
BF
Kholodov
L E
LE
D000700:Analgesics / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D002250:Carbon Radioisotopes; D004305:Dose-Response Relationship, Drug; D051379:Mice; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics
D000700:Analgesics; D002250:Carbon Radioisotopes; C044905:nicotinoyl-GABA; D005680:gamma-Aminobutyric Acid
Farmakokinetika pikamilona u zhivotnykh.