Novel arachidonate metabolites generated by cytochrome P450-dependent mono-oxygenases.
Cytochrome P450-dependent arachidonic acid (AA) metabolism by medullary thick ascending limb of the loop of Henle (mTALH) cells, corneal epithelium and other transporting epithelia, such as those of the intestines, generate metabolites which affect Na(+)-K(+)-ATPase activity, vasomotion and, thereby, organ function. Further, these novel AA metabolites contribute to the control of blood pressure in the SHR through participation in the local control of blood flow and in the regulation of extracellular fluid volume.
Carroll
M A
MA
Department of Pharmacology, New York Medical College, Valhalla 10595.
Quilley
C P
CP
McGiff
J C
JC
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D003315:Cornea / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008138:Loop of Henle / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism
D001095:Arachidonic Acids; D016718:Arachidonic Acid; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D011188:Potassium