[Effect of sex steroids on the activity of cardiac lysosomal enzymes].
Experiments on rats were staged to investigate the activity of lysosomal cardiac enzymes (beta-galactosidase, beta-glucosidase, acid phosphatase) against a varied endogenous background of sex steroids (in male and female animals and in females at various stages of the estrual cycle) and a possibility of direct influence of steroids on lysosomes. The investigation has shown sex differences in the activity of lysosomal cardiac enzymes of rats: total activity of beta-galactosidase, beta-glucosidase and acid phosphatase in the heart of male rats was higher than that of female rats. Correlation between the activity of lysosomal cardiac enzymes of female rats and stages of the estrual cycle was noted. Sex hormones at high (nonphysiological) concentrations could produce a direct effect on rat cardiac lysosomes, estradiol as distinct from testosterone, causing stabilization of lysosomal membranes.
Kan
A M
AM
Matiushin
A I
AI
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D004971:Estrus / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D012727:Sex Characteristics; D001616:beta-Galactosidase / Q000378:metabolism; D001617:beta-Glucosidase / Q000378:metabolism
D012739:Gonadal Steroid Hormones; D000135:Acid Phosphatase; D001617:beta-Glucosidase; D001616:beta-Galactosidase
Vliianie polovykh steroidov na aktivnost' lizosomal'nykh fermentov serdtsa.