The role of prostaglandins in NSAID induced renal dysfunction.
Renal prostaglandins (PG) play an important role in regulating renal hemodynamics and excretory function in 2 conditions (1) which effective arterial blood volume is reduced and (2) chronic renal failure is reduced. The use of nonsteroidal antiinflammatory drugs (NSAID) in patients with these conditions can produce a significant decline in renal function, including decreased glomerular filtration rate and solute and water excretion, by inhibiting renal cyclooxygenase, and thus, PG production. Results of preliminary investigation with the PGE1 analog misoprostol suggest that exogenous PG analogs may be effective in counteracting the effects of NSAID in such settings. Further clinical studies will be needed to establish the role of PG in this setting.
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Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
D000527:Alprostadil / Q000031:analogs & derivatives / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D007213:Indomethacin; D007668:Kidney / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology; D016030:Kidney Transplantation; D016595:Misoprostol; D011182:Postoperative Care; D011453:Prostaglandins / Q000502:physiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D011453:Prostaglandins; D016595:Misoprostol; D000527:Alprostadil; D007213:Indomethacin