Xenon-enhanced CT of the brain: effect of flow activation on derived cerebral blood flow measurements.
The errors associated with derivation of cerebral blood flow values by the xenon-enhanced CT method have been evaluated through computer simulations as a function of flow-activation patterns and different scanning protocols. The results of this study indicate that actual flow activation during inhalation increases the derived flow values in a systematic way. Compared with the errors introduced by CT noise and/or variations in scanning protocols, flow activation introduces relatively small errors in the derived flow value when the washin technique is used.
Good
W F
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Department of Diagnostic Radiology, University of Pittsburgh, PA 15261.
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D000280:Administration, Inhalation; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003198:Computer Simulation; D006801:Humans; D013268:Stimulation, Chemical; D014057:Tomography, X-Ray Computed; D014978:Xenon / Q000008:administration & dosage
D014978:Xenon