Factor VIII procoagulant: a marker of fibrinoid necrosis in normal term human placentae.
Factor VIII procoagulant (FVIIIPC) is a plasma glycoprotein cofactor for activated factor IX that activates factor X in prothrombin convertase and results in fibrin deposition. We have studied 50 normal term placentae for the presence of FVIIIPC, and found it in granular deposits almost exclusively in areas of fibrinoid necrosis. This observation was made in all fibrinoid areas. These deposits were associated with specific factors of the coagulation, anticoagulation and fibrinolytic pathways. These findings suggest coagulation and fibrinolysis are activated in areas of fibrinoid necrosis and indicate FVIIIPC is a marker of these areas.
Labarrere
C A
CA
Center for Reproduction and Transplantation Immunology, Methodist Hospital of Indiana, Indianapolis 46202.
Faulk
W P
WP
D015415:Biomarkers; D002824:Chorionic Villi / Q000378:metabolism / Q000473:pathology; D005164:Factor IX / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007150:Immunohistochemistry; D009336:Necrosis; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D011486:Protein C / Q000378:metabolism
D015415:Biomarkers; D011486:Protein C; D005169:Factor VIII; D005164:Factor IX