A comparison of serum and saliva paracetamol concentrations.
The relationship between serum and saliva paracetamol concentrations was investigated in twenty healthy volunteers. The plasma and saliva drug concentrations showed a significant correlation (r = 0.67). However the agreement between the two methods of measurement was poor with limits of agreement of -15.3 mg l-1 to +15.9 mg l-1 with mean sample values of 19.2 and 19.5 mg l-1 for plasma and saliva, respectively.
Smith
M
M
Anaesthetic Unit, St Thomas' Hospital, London.
Whitehead
E
E
O'Sullivan
G
G
Reynolds
F
F
D000082:Acetaminophen / Q000097:blood / Q000493:pharmacokinetics*; D000328:Adult; D003124:Colorimetry; D006801:Humans; D012463:Saliva / Q000737:chemistry*
D000082:Acetaminophen