title: [Acute lead poisoning].
abstract: A 36-year-old woman had for two months experienced progressively more marked diffuse abdominal pain, at times colicky, as well as nausea, vomiting and severe constipation. In addition, paraesthesias and motor weakness developed in the thighs. This was accompanied by a normochromic, normocytic anaemia with a haemoglobin concentration of 9.6 g/l. A short time later her mother and daughter also fell ill with similar symptoms. After symptomatic treatment had failed, secondary coproporphyria due to lead poisoning was found. The poisoning had resulted from criminal contamination of food, especially of cocoa powder, with lead acetate. Raised lead concentrations in serum were found in two other members of the family. In all the patients treatment was undertaken with sodium calcium edetate (20 mg/kg body-weight) in several three-day cycles, achieving a gradual fall in serum lead concentration. When the level had fallen to below 4 mumol/l the symptoms disappeared. Below 3 mumol/l porphyria was no longer demonstrable and the anaemia regressed. It is pointed out that, as lead poisoning may be fatal, it should be considered in the differential diagnosis of acute abdominal colic of unclear cause.
authors.affiliation: Medizinische Klinik, Krankenhaus Bad Cannstatt, Stuttgart.
authors.forename: E
authors.initials: E
authors.lastname: Höring
authors.forename: K U
authors.initials: KU
authors.lastname: Radtke
authors.forename: U
authors.initials: U
authors.lastname: von Gaisberg
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002648:Child; D003085:Colic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000652:urine; D003306:Coproporphyrins / Q000652:urine; D003937:Diagnosis, Differential; D004492:Edetic Acid / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007855:Lead Poisoning / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000652:urine; D011164:Porphyrias / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000652:urine
chemical_list: D003306:Coproporphyrins; D004492:Edetic Acid
vernacular_title: Akute Bleivergiftung.