Treatment of pure red-cell aplasia following major ABO-mismatched T-cell-depleted bone marrow transplantation. Two case reports with successful response to plasmapheresis.
Major ABO-mismatched bone marrow transplantation (BMT) may be accompanied by red-cell haemolysis, but pure red-cell aplasia following BMT is a rare complication. Two cases of transient pure red-cell aplasia following T-lymphocyte-depleted BMT for a period of greater than 20 weeks are described, both of which responded to one cycle of plasmapheresis. The prompt response of the two patients described with red-cell aplasia with no evidence of haemolysis suggests that plasmapheresis may be considered in such clinical situations as a first treatment of choice before attempting more complex modes of therapy.
Or
R
R
Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
Naparstek
E
E
Mani
N
N
Slavin
S
S
D000017:ABO Blood-Group System / Q000276:immunology; D000293:Adolescent; D000328:Adult; D001787:Blood Group Incompatibility / Q000150:complications* / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D012010:Red-Cell Aplasia, Pure / Q000209:etiology / Q000628:therapy*; D012156:Reticulocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000017:ABO Blood-Group System