5-Hydroxytryptamine induces electrogenic secretion and simultaneously activates a modulating inhibitory neural circuit in rat small intestine in vitro.
5-Hydroxytryptamine (5-HT) induces electrogenic secretion across rat jejunum and ileum in vitro expressed as an increase in the short-circuit current. Enhancement of this secretory response by previous serosal addition of atropine (1 microM), hexamethonium (0.2 microM) or yohimbine (0.2 microM), especially in the ileum, indicated that 5-HT simultaneously activates an anti-secretory, inhibitory, enteric, neural, cholinergic-adrenergic pathway (ENCAP). A similar inhibitory ENCAP activated by 5-HT has previously been characterized in rat colon in vitro.
Beesley
A
A
Department of Biomedical Science, University of Sheffield.
Levin
R J
RJ
D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology; D004553:Electric Conductivity / Q000187:drug effects; D066298:In Vitro Techniques; D007419:Intestinal Secretions / Q000187:drug effects*; D007421:Intestine, Small / Q000502:physiology*; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D001337:Autonomic Agents; D012701:Serotonin