[The effect of perfluordecaline on the activity of phase III xenobiotic transformation enzymes].
Injection of perfluorodecaline to rats caused an increase of the phase II xenobiotic biotransformation enzyme activities followed by cytochrome P-450 induction. The activities of liver microsomal UDP-glucuronosyl transferase and glutathione transferase increased by 130 and 40%, respectively, against the control level. The increase of the cytosolic glutathione transferase activity was insignificant In contrast, the activity of sulfotransferase decreased about 2-fold. The role of modification of xenobiotic biotransformation enzymes in the biological effect of perfluorodecaline is discussed.
Kalinina
E V
EV
Obraztsov
V V
VV
Shekhtman
D G
DG
Gudkova
O V
OV
Kukushkin
N I
NI
Saprin
A N
AN
D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D003600:Cytosol / Q000201:enzymology; D004790:Enzyme Induction; D005466:Fluorocarbons / Q000493:pharmacokinetics / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D015262:Xenobiotics / Q000493:pharmacokinetics*
D005466:Fluorocarbons; D015262:Xenobiotics; C008805:perfluorodecalin; D003577:Cytochrome P-450 Enzyme System; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase
Vliianie perftordekalina na aktivnost' fermentov II fazy biotransformatsii ksenobiotikov.