[Effect of chorionic gonadotropin on the structure and endocrine function of the thymus gland in mice].
The thymic secretory function changes in the pubertal female mice under the influence of chorionic gonadotrophin (CG). The latter is activated after administration of hormone in doses, corresponding to its levels in animals in different terms of pregnancy and is depressed with doses, greatly exceeding those levels. The lack of the effect in thymectomized mice testifies to the realization of the modulating CG action at the thymus level. Changes of mass and cellularity of the thymus and spleen reflect dose-dependent alteration of the thymocyte migration rate.
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IF
D000818:Animals; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007958:Leukocyte Count / Q000187:drug effects; D051379:Mice; D008954:Models, Biological; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects*; D013934:Thymectomy; D013935:Thymic Factor, Circulating / Q000378:metabolism*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D006063:Chorionic Gonadotropin; D013935:Thymic Factor, Circulating
Vliianie khorionicheskogo gonadotropina na strukturu i éndokrinnuiu funktsiiu vilochkovoĭ zhelezy u mysheĭ.