Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids.
C22:1 omega 5-anacardic acid was found to be a good inhibitor of both potato lipoxygenase and ovine prostaglandin endoperoxide synthase with approximate IC50's of 6 and 27 microM, respectively. Very similar inhibition was seen with the crude exudate, rich in omega 5-anacardic acids, from glandular trichomes of an arthropod-resistant strain of geranium, Pelargonium xhortorum. The saturated anacardic acid (C22:0 sat), abundant in the trichome exudate of susceptible strains, was nearly as inhibitory toward both prostaglandin endoperoxide synthase and lipoxygenase as the omega 5-unsaturated compound. However, the dimethyl derivative of C22:1 omega 5-anacardic acid was a poor inhibitor of prostaglandin endoperoxide synthase and caused only moderate (32%) inhibition of lipoxygenase even at 135 microM. The possible role of prostaglandin endoperoxide synthase and lipoxygenase inhibition in the enhanced pest resistance of geraniums which produce the omega 5-AnAs is discussed.
Grazzini
R
R
Interdepartmental Graduate Program in Genetics, Pennsylvania State University, University Park 16802.
Hesk
D
D
Heininger
E
E
Hildenbrandt
G
G
Reddy
C C
CC
Cox-Foster
D
D
Medford
J
J
Craig
R
R
Mumma
R O
RO
D001241:Aspirin / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D010944:Plants / Q000032:analysis; D012459:Salicylates / Q000494:pharmacology*
D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D012459:Salicylates; D001241:Aspirin