title: [The immunological status indices of monkeys inoculated with a meningococcal B vaccine].
abstract: The method for the determination of bacterial antibodies to group B meningococci was worked out. The method was used for the determination of antibodies to group B meningococcal vaccine produced in the USSR. The dynamic study of antibodies to protein, polysaccharide and lipopolysaccharide antigens of group B meningococci was made by the method of the enzyme immunoassay (EIA), and the safety of the vaccine was studied by the determination of autoantibodies active against brain tissue antigens. The data thus obtained were indicative of the immunological activity of group B protein-polysaccharide vaccines, manifested by the capacity for stimulating bactericidal antibodies whose level increased 8- to 10-fold after the immunization of monkeys in 2 and 3 injections. Similarity in the dynamics of the formation of bacteriolysins and antibodies to protein antigen, as determined in EIA, was noted. The vaccine was found to stimulate no cytotoxic anticerebral antibodies in the glia migration test, which was indicative of the safety of group B meningococcal vaccine.
authors.forename: L I
authors.initials: LI
authors.lastname: Krasnoproshina
authors.forename: T V
authors.initials: TV
authors.lastname: Kil'diushevskaia
authors.forename: T A
authors.initials: TA
authors.lastname: Serova
authors.forename: T A
authors.initials: TA
authors.lastname: Chulok
authors.forename: E K
authors.initials: EK
authors.lastname: Dzhikidze
authors.forename: E Ia
authors.initials: EIa
authors.lastname: Balaeva
authors.forename: N T
authors.initials: NT
authors.lastname: Iakovleva
authors.forename: A P
authors.initials: AP
authors.lastname: Alliluev
authors.forename: O V
authors.initials: OV
authors.lastname: Kotel'nikova
authors.forename: A B
authors.initials: AB
authors.lastname: Petrov
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D001428:Bacterial Vaccines / Q000009:adverse effects / Q000276:immunology*; D001921:Brain / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D007114:Immunization / Q000379:methods; D008070:Lipopolysaccharides / Q000276:immunology; D008253:Macaca mulatta; D009345:Neisseria meningitidis / Q000276:immunology*; D009457:Neuroglia / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000276:immunology; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D001323:Autoantibodies; D001428:Bacterial Vaccines; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial
vernacular_title: Pokazateli immunologicheskogo statusa obez'ian, privitykh meningokokkovoĭ B-vaktsinoĭ.