Cervical mucus score and in vitro sperm mucus interaction in spontaneous and clomiphene citrate cycles.
OBJECTIVE
Assessment of the effects of clomiphene citrate (CC) on cervical mucus score and in vitro sperm mucus interaction.


METHODS
Prospective study of cervical mucus score and in vitro sperm mucus interaction in a spontaneous cycle followed by a CC cycle to compare paired data.


METHODS
Tertiary institutional infertility clinic.


METHODS
Twenty-two couples with primary unexplained infertility were studied in both cycles.


METHODS
Clomiphene citrate (150 mg) on days 5 to 9 in CC cycles.


METHODS
Cervical mucus score and sperm-mucus penetration test score.


RESULTS
Mean cervical mucus score in spontaneous cycles was 9.3 (95% confidence interval [CI] 8.4 to 10.2) and in CC cycles 5.6 (95% CI 4.6 to 6.6), P less than 0.0001. Sperm-mucus penetration test score in spontaneous cycles was 11.4 (95% CI 7.6 to 15.2) and in CC cycles 3.9 (95% CI 1.17 to 6.63), P less than 0.01.


CONCLUSIONS
Clomiphene citrate has an adverse effect on both cervical mucus score and sperm-mucus penetration.
Randall
J M
JM
Department of Obstetrics and Gynaecology, University of Aberdeen, Maternity Hospital, Scotland.
Templeton
A
A
D000328:Adult; D002582:Cervix Mucus / Q000378:metabolism*; D002996:Clomiphene / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008597:Menstrual Cycle / Q000502:physiology*; D013094:Spermatozoa / Q000502:physiology*
D002996:Clomiphene