The effect of 1-hydroxyvitamin D3 for prolongation of leukemic transformation-free survival in myelodysplastic syndromes.
Leukemic transformation (LT) free survival was studied in 30 patients with myelodysplastic syndromes (MDS). In 15 cases, 4-6 micrograms/day of 1-hydroxyvitamin D3 was administered, for a median duration of 17 months (D-group), other subjects had no therapy (N group). LT free survival of the D group had significant advantage over that of the N group according to the Kaplan-Meier method (P less than 0.001). In addition, 7 cases in the N group developed acute leukemia, in contrast to only one in the D group (P less than 0.05). These results suggest that oral administration of 1-hydroxyvitamin D3 prevents the progression of MDS to overt leukemia under the effect of differentiation capacity from blasts to monocytes.
Motomura
S
S
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
Kanamori
H
H
Maruta
A
A
Kodama
F
F
Ohkubo
T
T
D000208:Acute Disease; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D007938:Leukemia / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000188:drug therapy*; D016019:Survival Analysis; D013997:Time Factors
D006887:Hydroxycholecalciferols; C008088:alfacalcidol