Modulation of vocal and nonvocal behavior in adult squirrel monkeys by selective MAO-A and MAO-B inhibition.
The acute effects of monoamine oxidase inhibitors L-deprenyl (0.5-5.0 mg/kg), clorgyline (1.0-10.0 mg/kg), and milacemide (100-400 mg/kg) on the behavior of adult male squirrel monkeys were examined during brief social separations beginning 60 min after subcutaneous drug administration. All three drugs selectively reduced the rate of calling during social separation at doses which did not affect time spent in locomotion, nor the frequency of vigilance-checking. Deprenyl and milacemide, but not clorgyline, produced concurrent decreases in locomotion at the higher doses tested. At threshold doses, clorgyline, but not deprenyl or milacemide, increased call duration and decreased call peak frequency compared to vehicle control values. Plasma levels of MHPG were decreased by an optimal dose of clorgyline but not by deprenyl or milacemide, indicating that substrate specificity was maintained at the drug doses employed. We conclude that different MAO substrates mediate different aspects of vocal and nonvocal behavior in adult male squirrel monkeys.
Newman
J D
JD
Laboratory of Comparative Ethology, NICHD, NIH, Bethesda, MD 20892.
Winslow
J T
JT
Murphy
D L
DL
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D003010:Clorgyline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D012016:Reference Values; D012453:Saimiri / Q000502:physiology*; D012642:Selegiline / Q000494:pharmacology*; D012919:Social Behavior; D012934:Social Isolation; D014828:Vocalization, Animal / Q000187:drug effects*
D000081:Acetamides; D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; C039332:milacemide; D012642:Selegiline; D008995:Monoamine Oxidase; D003010:Clorgyline