Preventive and therapeutic effects of lithium carbonate on acute radiation injury of hemopoietic system in mice.
The administration of Li2CO3 to female LACA mice for three consecutive days before or after 4Gy whole body gamma-irradiation appeared to have both preventive and therapeutic effects on radiation-induced leucopenia, especially on the depression of CFU-GM. It is effective in small dosage, short course, and even when given 24 hours after irradiation.
Ke
X Y
XY
Research Center of Occupational Medicine, Third Hospital, Beijing Medical University.
Wang
Y F
YF
Jia
T Z
TZ
D000818:Animals; D003114:Colony-Forming Units Assay; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D007970:Leukopenia / Q000188:drug therapy / Q000517:prevention & control*; D008094:Lithium / Q000494:pharmacology / Q000627:therapeutic use*; D016651:Lithium Carbonate; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000517:prevention & control*; D014916:Whole-Body Irradiation
D016651:Lithium Carbonate; D008094:Lithium