In vitro ablation of normal and diseased vascular tissue by a fiber-transmitted holmium laser.
An in vitro study was performed to test the ablative potential of a fiber-transmitted pulsed holmium laser (2.1 microns) applied to normal vascular wall, lipomatous plaques, and calcified plaques. Different fluences per pulse of 42, 80, 205, and 315 J/cm2 were used. Ablation of normal tissue and lipomatous plaques was achieved with all power settings. Effective ablation of calcified plaques, however, occurred only after a minimum fluence of 205 J/cm2, and the effect was significantly less pronounced compared to ablation of soft lesions.
Vorwerk
D
D
Department Diagnostic Radiology, Technical University of Aachen, Germany.
Zolotas
G
G
Hessel
S
S
Adam
G
G
Wondrazek
F
F
Günther
R W
RW
D016342:Angioplasty, Laser / Q000295:instrumentation* / Q000379:methods; D001011:Aorta / Q000601:surgery* / Q000648:ultrastructure; D001018:Aortic Diseases / Q000473:pathology / Q000601:surgery*; D001161:Arteriosclerosis / Q000473:pathology / Q000601:surgery*; D002102:Cadaver; D005069:Evaluation Studies as Topic; D005336:Fiber Optic Technology / Q000295:instrumentation; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning