title: [Experience with hydrophilic silicone disc intraocular lenses].
abstract: When oxygen plasma was used for plasma etching it was possible to hydrophilize the surface of silicone intraocular lenses (IOLs) without changing the chemical composition or the properties of deeper layers of the polymer. The modification was characterized by surface analysis. (Electron spectroscopy = XPS, contact angle estimations) and by scanning electron microscope. A cytotoxic influence of the modified surface could be excluded by cell culture experiments in which we evaluated cell spreading, cell morphology, DNA synthesis and protein synthesis. In vivo experiments on rabbits showed that the postoperative foreign body reaction was not significantly influenced by the hydrophilization of the IOL surface. Over the entire follow-up period (12 weeks), there was a reduced tendency to induce posterior synechiae in the group with hydrophilized lenses (P = 0.009). The number of dislocations and the incidence of posterior opacification did not differ significantly; on the other hand there were indications of improved adhesion to the posterior lens capsule of the hydrophilized IOL.
authors.affiliation: Institut für Pathologie der Medizinischen Fakultät der RWTH, Aachen, Bundesrepublik Deutschland.
authors.forename: H J
authors.initials: HJ
authors.lastname: Hettlich
authors.forename: R
authors.initials: R
authors.lastname: Kaufmann
authors.forename: W
authors.initials: W
authors.lastname: Hunold
authors.forename: H
authors.initials: H
authors.lastname: Harmeyer
authors.forename: B
authors.initials: B
authors.lastname: Janssen
authors.forename: C
authors.initials: C
authors.lastname: Mittermayer
mesh_terms: D000818:Animals; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology; D015743:Giant Cells, Foreign-Body / Q000473:pathology; D007903:Lens Capsule, Crystalline / Q000473:pathology; D007910:Lenses, Intraocular; D011183:Postoperative Complications / Q000473:pathology*; D011474:Prosthesis Design; D011817:Rabbits; D012828:Silicones
chemical_list: D012828:Silicones
vernacular_title: Erfahrungen mit hydrophilisierten Silikon-Disk-Intraokularlinsen.