title: Treatment of pure red-cell aplasia following major ABO-mismatched T-cell-depleted bone marrow transplantation. Two case reports with successful response to plasmapheresis.
abstract: Major ABO-mismatched bone marrow transplantation (BMT) may be accompanied by red-cell haemolysis, but pure red-cell aplasia following BMT is a rare complication. Two cases of transient pure red-cell aplasia following T-lymphocyte-depleted BMT for a period of greater than 20 weeks are described, both of which responded to one cycle of plasmapheresis. The prompt response of the two patients described with red-cell aplasia with no evidence of haemolysis suggests that plasmapheresis may be considered in such clinical situations as a first treatment of choice before attempting more complex modes of therapy.
authors.affiliation: Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Or
authors.forename: E
authors.initials: E
authors.lastname: Naparstek
authors.forename: N
authors.initials: N
authors.lastname: Mani
authors.forename: S
authors.initials: S
authors.lastname: Slavin
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology; D000293:Adolescent; D000328:Adult; D001787:Blood Group Incompatibility / Q000150:complications* / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D012010:Red-Cell Aplasia, Pure / Q000209:etiology / Q000628:therapy*; D012156:Reticulocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000017:ABO Blood-Group System