Systemic mannitol increases retinal adhesiveness measured in vitro.
Pigmented rabbits were given mannitol intravenously, and at various times thereafter blood osmolality was measured and eyes were enucleated to measure retinal adhesiveness to the retinal pigment epithelium. Both blood osmolality and retinal adhesion increased in proportion to the dose of mannitol. We found a measurable increase in retinal adhesion as early as 10 minutes and as late as 4 hours after mannitol injection. We suspect that mannitol dehydrates the subretinal space and thereby enhances the adhesive properties of the interphotoreceptor matrix or tightens the interdigitation between photoreceptors and pigment epithelial cells. Our data suggest that mannitol could have clinical application in the management of retinal detachments.
Yao
X Y
XY
Department of Ophthalmology, Stanford University School of Medicine, CA 94305.
Moore
K T
KT
Marmor
M F
MF
D000818:Animals; D001769:Blood; D002448:Cell Adhesion / Q000187:drug effects; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008353:Mannitol / Q000008:administration & dosage / Q000494:pharmacology*; D009994:Osmolar Concentration; D010857:Pigment Epithelium of Eye / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D011817:Rabbits; D012160:Retina / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D013997:Time Factors
D008353:Mannitol