title: Antigenic diversity of Cowdria ruminantium isolates determined by cross-immunity.
abstract: Antigenic diversity in five stocks of the tick-borne rickettsia Cowdria ruminantium, the causal agent of heartwater disease of ruminants, was studied by cross-immunity trials in goats and sheep. Complete absence of cross-protection was found only between the Kümm and Kwanyanga stocks, and in all other combinations there were various degrees of cross-immunity. Immunological strain differences were more pronounced in goats than in sheep.
authors.affiliation: Department of Tropical Veterinary Medicine and Protozoology, Institute of Infectious Diseases and Immunology, Utrecht, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Jongejan
authors.forename: M J
authors.initials: MJ
authors.lastname: Thielemans
authors.forename: C
authors.initials: C
authors.lastname: Brière
authors.forename: G
authors.initials: G
authors.lastname: Uilenberg
mesh_terms: D000818:Animals; D000940:Antigenic Variation; D000942:Antigens, Bacterial / Q000276:immunology*; D003429:Cross Reactions; D015511:Goat Diseases / Q000276:immunology*; D006041:Goats; D006357:Heartwater Disease / Q000276:immunology*; D012287:Rickettsiaceae / Q000276:immunology*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial