Synthesis and pharmacological evaluation of pyrazolopyrimidobenzoxazole and pyrazolopyrimidobenzothiazole derivatives.
As a part of research on polieterocycles compounds with condensed nuclei, containing pyrimidine ring, as potential antalgic/anti-inflammatory drugs, pyrazolopyrimidobenzoxazole and pyrazolopyrimidobenzothiazole were prepared and tested. None of the substances shows significative activities in vivo.
Russo
F
F
Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania.
Guccione
S
S
Romeo
G
G
Monsù Scolaro
L
L
Caruso
A
A
Cutuli
V
V
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001583:Benzoxazoles; D011720:Pyrazoles; D011725:Pyridines; D013844:Thiazoles