title: Tumor cell motility.
abstract: Tumor cell motility is required for invasion and metastasis. The locomotory machinery of the cell includes cell projections called pseudopodia which are regulated by a complicated linkage between cell surface receptors or sensors and the internal cytoskeleton. Recently a new class of motility stimulating cytokines have been identified. These cytokines can function as autocrine motility factors and require a pertussis toxin sensitive G protein pathway to transduce a random motile response.
authors.affiliation: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
authors.forename: L A
authors.initials: LA
authors.lastname: Liotta
authors.forename: M L
authors.initials: ML
authors.lastname: Stracke
authors.forename: S A
authors.initials: SA
authors.lastname: Aznavoorian
authors.forename: M E
authors.initials: ME
authors.lastname: Beckner
authors.forename: E
authors.initials: E
authors.lastname: Schiffmann
mesh_terms: D014408:Biomarkers, Tumor / Q000502:physiology; D002465:Cell Movement; D002633:Chemotaxis; D005109:Extracellular Matrix / Q000502:physiology; D005956:Glucose-6-Phosphate Isomerase / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D007335:Insulin-Like Growth Factor II / Q000502:physiology; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D011554:Pseudopodia / Q000502:physiology; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D005956:Glucose-6-Phosphate Isomerase