[5-Acyloxydioxolanones as prodrugs of non-steroidal anti-inflammatory agents. 1].
The derivatissation of various acidic non-steroidal anti-inflammatory drugs to 5-acyloxy-1,3-dioxolan-4-ones is described. The synthesis of the title compounds is achieved by reaction of 5-bromo-1,3-dioxolan-4-ones with the salts of the carbonic acids.
Schwenker
G
G
Pharmazeutich-Chemisches Institut, Universität Heidelberg.
Stiefvater
K
K
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D004148:Dioxolanes / Q000138:chemical synthesis* / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004148:Dioxolanes; D011355:Prodrugs
5-Acyloxydioxolanone als Prodrugs nichtsteroidaler Antirheumatika, 1. Mitt.