title: Synthesis and antibacterial activity of new C-10 quinolonyl-cephem esters.
abstract: A series of cephalosporins derived from cephalothin containing an ester-linked quinolonyl substituent at the C-10 position (C-10 quinolonyl-cephem esters) has been prepared and evaluated for in vitro antibacterial activity. The C-10 quinolonyl-cephem esters exhibited a broadened spectrum of activity when compared with cephalothin and the corresponding quinolones, including activity against beta-lactamase-producing bacteria.
authors.affiliation: Norwich Eaton Pharmaceuticals, Inc., Procter & Gamble Company, Norwich, New York 13815.
authors.forename: T P
authors.initials: TP
authors.lastname: Demuth
authors.forename: R E
authors.initials: RE
authors.lastname: White
authors.forename: R A
authors.initials: RA
authors.lastname: Tietjen
authors.forename: R J
authors.initials: RJ
authors.lastname: Storrin
authors.forename: J R
authors.initials: JR
authors.lastname: Skuster
authors.forename: J A
authors.initials: JA
authors.lastname: Andersen
authors.forename: C C
authors.initials: CC
authors.lastname: McOsker
authors.forename: R
authors.initials: R
authors.lastname: Freedman
authors.forename: F J
authors.initials: FJ
authors.lastname: Rourke
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002512:Cephalothin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D004952:Esters; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D004952:Esters; D011804:Quinolines; D002512:Cephalothin