Antinociceptive action of GABA-mimetic agent--N-phthaloyl GABA.
N-phthaloyl GABA (P-GABA), a nonselective GABA-ergic drug, showed positive analgesic response in four different models in mice, viz-tail immersion, tail clip, hot plate and writhing-induced by acetic acid. Antinociceptive ED50 (ip in mice) of P-GABA was lowest in tail immersion method (ED50 = 24.27, mg/kg). Though pethidine (10 mg/kg, ip) significantly potentiated the antinociceptive action of P-GABA (20 mg/kg, ip), pretreatment of naloxone (5 mg/kg, im) did not influence the same. Pretreatment with atropine (10 mg/kg, im), picrotoxin (0.08 mg/kg) and 3-mercaptopropionic acid (2 mg/kg) reduced the antinociceptive action of P-GABA significantly. But pretreatment with bicuculline (0.4 mg/kg), a specific GABA antagonist, did not reduce the antinociceptive action of P-GABA.
Banerji
S
S
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Bhowmick
S
S
Bera
M
M
Pal
M
M
Pal
S P
SP
D000700:Analgesics; D000818:Animals; D008297:Male; D051379:Mice; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D000700:Analgesics; C063763:N-phthaloyl-4-aminobutyric acid; D005680:gamma-Aminobutyric Acid