title: [Combined action of anti-arrhythmia agents].
abstract: A significant potentiation of antiarrhythmic effect was observed in 121 dogs with arrhythmias 24 and 48 hours after the coronary artery ligation when the following drugs were combined: N-propylajmaline bromide (1A class) and trimecaine (1B class), quinidine (1A class) and trimecaine, N-propylajmaline bromide and anaprilin (2 class). The potentiation is attributed to the different molecular mechanisms of action of the drugs.
authors.forename: E I
authors.initials: EI
authors.lastname: Gendenshteĭn
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Kostin
authors.forename: V P
authors.initials: VP
authors.lastname: Balashov
authors.forename: V E
authors.initials: VE
authors.lastname: Oleĭnikov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D004285:Dogs; D004359:Drug Therapy, Combination; D011219:Prajmaline / Q000008:administration & dosage / Q000494:pharmacology; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology; D011802:Quinidine / Q000008:administration & dosage / Q000494:pharmacology; D014288:Trimecaine / Q000008:administration & dosage / Q000494:pharmacology; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D011219:Prajmaline; D011433:Propranolol; D014700:Verapamil; D014288:Trimecaine; D011802:Quinidine
vernacular_title: Sochetannoe kombinirovannoe deĭstvie antiaritmicheskikh sredstv.