Spatial correlation between thyroid epithelial cells expressing class II MHC molecules and interferon-gamma-containing lymphocytes in human thyroid autoimmune disease.
In this immunohistochemical study we addressed the question whether aberrant class II MHC expression by thyroid epithelial cells (thyrocytes) in established thyroid autoimmune disease is the result of release of interferon-gamma (IFN-gamma) by adjacent lymphocytes. Thyroids from eight cases of Hashimoto's thyroiditis, 13 cases of Graves' disease and 10 cases of focal thyroiditis were studied. Both thyrocytes expressing class II MHC and lymphocytes containing immunoreactive IFN-gamma were found in all 31 autoimmune thyroids. In a serial section study of these thyroids, IFN-gamma-expressing lymphocytes were found within 50 microns of class II MHC-positive thyrocytes in 89% of 282 randomly selected fields. Conversely, class II MHC-positive thyrocytes were found within 50 micron of aggregates of IFN-gamma-positive lymphocytes in 82% of 272 randomly selected fields. These findings support the view that in established thyroid autoimmune disease expression of class II MHC by thyrocytes is the result of local release of IFN-gamma.
Hamilton
F
F
Department of Pathology, Royal Infirmary, Glasgow, Scotland, UK.
Black
M
M
Farquharson
M A
MA
Stewart
C
C
Foulis
A K
AK
D001327:Autoimmune Diseases / Q000276:immunology* / Q000378:metabolism; D002277:Carcinoma / Q000276:immunology / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000276:immunology / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007371:Interferon-gamma / Q000096:biosynthesis*; D008214:Lymphocytes / Q000378:metabolism*; D013955:Thyroglossal Cyst / Q000276:immunology / Q000378:metabolism; D013959:Thyroid Diseases / Q000276:immunology* / Q000378:metabolism; D013961:Thyroid Gland / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000276:immunology / Q000378:metabolism; D013966:Thyroiditis / Q000276:immunology / Q000378:metabolism; D013967:Thyroiditis, Autoimmune / Q000276:immunology / Q000378:metabolism
D000949:Histocompatibility Antigens Class II; D007371:Interferon-gamma