The role of the low density lipoprotein receptor pathway in the delivery of lipophilic photosensitizers in the photodynamic therapy of tumours.
Lipoproteins are now recognized as major blood carriers of many hydrophobic porphyrins and related chromophores which are being investigated as possible photosensitizers in the photodynamic therapy of tumours. In vitro and in vivo studies have demonstrated the role of the low density lipoprotein (LDL) receptor pathway in the delivery of photosensitizers to tumour cells and its importance in porphyrin accumulation by tumours. Lysosomes, which are involved in the cellular processing of LDL, are important intracellular targets in the LDL-porphyrin-induced phototoxicity. The use of the LDL receptor pathway as a tool for enhancing the selectivity of photosensitizer delivery to tumour cells appears to be a promising field of research in the photodynamic therapy of tumours.
Mazière
J C
JC
Laboratoire de Physico-Chimie de l'Adaptation Biologique, INSERM U312, Muséum National d'Histoire Naturelle, Paris, France.
Morlière
P
P
Santus
R
R
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy / Q000379:methods*; D011166:Porphyrins / Q000378:metabolism; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D011973:Receptors, LDL / Q000502:physiology*
D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; D011973:Receptors, LDL