title: Temperature regulation of the cryptococcal phenoloxidase.
abstract: Melanin formation at 37 degrees C has been proposed as a virulence factor in Cryptococcus neoformans. However, whereas catecholamine uptake is maintained at this temperature, phenoloxidase, which catalyses the oxidation of catecholamine to melanin, is severely decreased in most wild type strains cultivated at 37 degrees C.
authors.affiliation: Research Service, McGuire Veterans Affairs Medical Centre, Richmond, Virginia 23249.
authors.forename: E S
authors.initials: ES
authors.lastname: Jacobson
authors.forename: H S
authors.initials: HS
authors.lastname: Emery
mesh_terms: D002395:Catecholamines / Q000378:metabolism; D003455:Cryptococcus neoformans / Q000201:enzymology* / Q000472:pathogenicity; D008543:Melanins / Q000096:biosynthesis; D014442:Monophenol Monooxygenase / Q000378:metabolism*; D010084:Oxidation-Reduction; D013696:Temperature; D014510:Urease / Q000378:metabolism; D014774:Virulence
chemical_list: D002395:Catecholamines; D008543:Melanins; D014442:Monophenol Monooxygenase; D014510:Urease