[Study by radiolabelling of the residual time of a therapeutic gel in the nasal fossae].
The residence times in the nose of the liquid and gel forms of the same therapeutic preparation were compared in 7 healthy subjects. A 50 microliters drop of the preparation, labelled with Tc99m, was placed down the head of the inferior turbinate, and the kinetics of its clearance from the site of deposition was monotired using a gamma camera, during 60 minutes for the liquid and 120 minutes for the gel. The average times for removal of 50% of the labelled material from the site of deposition were 10.3 minutes and 28.6 minutes for the liquid and gel forms respectively. The slower removal of the gel form is probably due to a mechanical effect, and seems to affect the whole nasal passage. The contact time between the preparation and the mucosa is increased in this galenic form and this should improve the efficiency of the preparation.
Renon
P
P
Hôpital d'Instruction des Armées, Sainte-Anne, Services d'O.R.L. et de Médecine, Toulon Naval, France.
Hee
J
J
Elizagaray
A
A
Courtois
A
A
Llull
J B
JB
Guillerm
R
R
D000328:Adult; D000368:Aged; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism*; D012996:Solutions; D016284:Technetium Tc 99m Pentetate; D013997:Time Factors
D005782:Gels; D012996:Solutions; D016284:Technetium Tc 99m Pentetate
Etude par radiomarquage de la rémanence d'un gel thérapeutique dans les fosses nasales.