Effects of exposure misclassification on regression analyses of epidemiologic follow-up study data.
In epidemiologic studies, subjects are often misclassified as to their level of exposure. Ignoring this misclassification error in the analysis introduces bias in the estimates of certain parameters and invalidates many hypothesis tests. For situations in which there is misclassification of exposure in a follow-up study with categorical data, we have developed a model that permits consideration of any number of exposure categories and any number of multiple-category covariates. When used with logistic and Poisson regression procedures, this model helps assess the potential for bias when misclassification is ignored. When reliable ancillary information is available, the model can be used to correct for misclassification bias in the estimates produced by these regression procedures.
Reade-Christopher
S J
SJ
Research Triangle Institute, North Carolina 27709.
Kupper
L L
LL
D001699:Biometry; D004812:Epidemiologic Methods; D005500:Follow-Up Studies; D016015:Logistic Models; D015233:Models, Statistical; D016012:Poisson Distribution; D012044:Regression Analysis