Interrelation of xanthine oxidase and dehydrogenase and L-gulonolactone oxidase in animal tissues.
There is a correlation between phylogeny and the activities of L-gulonolactone oxidase (LGO), the key enzyme responsible for ascorbic acid (AH2) synthesis in animals and total xanthine oxidase and dehydrogenase [XOD(D/O)], the enzyme responsible for the production of endogenous superoxide radical (O2-.). LGO appears in the kidneys of amphibians and reptiles but livers of mammals. XOD(D/O) also is present mainly in the kidneys of amphibians and reptiles and livers of mammals. AH2 is a potential scavenger of O2-. and it appears that tissue specific expression of LGO takes place to counteract the endogenous O2-. toxicity. The interrelation of XOD(D/O) and LGO was also observed in the liver of rats during prenatal to postnatal development.
Nandi
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A
Department of Biochemistry, University College of Science, Calcutta, India.
Chatterjee
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IB
D000818:Animals; D001001:Anura; D050544:L-Gulonolactone Oxidase; D008099:Liver / Q000254:growth & development / Q000378:metabolism; D008322:Mammals; D010100:Oxygen / Q000378:metabolism; D012104:Reptiles; D013401:Sugar Alcohol Dehydrogenases / Q000378:metabolism*; D014968:Xanthine Dehydrogenase / Q000378:metabolism*; D014969:Xanthine Oxidase / Q000378:metabolism*
D013401:Sugar Alcohol Dehydrogenases; D050544:L-Gulonolactone Oxidase; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase; D010100:Oxygen