title: Effect of DN-1417 on photosensitivity and cortically kindled seizure in Senegalese baboons, Papio papio.
abstract: The effect of DN-1417, a thyrotropin-releasing hormone (TRH) analogue, on photosensitivity and cortically kindled seizures was examined in seven Senegalese baboons (Papio papio). Intravenous (i.v.) administration of 2 mg/kg had no effect on either photosensitivity or cortically kindled seizures. When this agent was administered intracisternally, both the photomyoclonic response and cortically kindled seizures were suppressed for 4-5 days. A study of the transcallosal response also showed a long-lasting attenuation of the early positive wave (P1) amplitude (peak latency, 5-10 ms) elicited by a single stimulus after cisternal injection of DN-1417. These findings are consistent with the assumption that endogenous TRH is involved in suppression of epileptic seizures.
authors.affiliation: Division of Neurosciences, University Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Baba
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: J A
authors.initials: JA
authors.lastname: Wada
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006728:Hormones / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008027:Light; D008297:Male; D008959:Models, Neurological; D010215:Papio / Q000235:genetics / Q000502:physiology*; D012640:Seizures / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control*; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D006728:Hormones; D013973:Thyrotropin-Releasing Hormone; C029762:DN 1417