Basal and ATP-stimulated phosphoinositol metabolism in fusing rat skeletal muscle cells in culture.
A considerable rise in inositol phosphates was observed at the beginning of myoblast fusion. Extracellular ATP, through P2-purinergic receptors, induced inositol phosphate accumulation before and after fusion; however, no effect of ATP on phosphoinositol levels could be detected during the period of fusion. The possibility of ATP being a fusion signal is discussed.
Keresztes
M
M
Institute of Biochemistry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Häggblad
J
J
Heilbronn
E
E
D000241:Adenosine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D007294:Inositol / Q000378:metabolism; D007295:Inositol Phosphates / Q000378:metabolism*; D007700:Kinetics; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D051381:Rats
D007295:Inositol Phosphates; D007294:Inositol; D000255:Adenosine Triphosphate; D000241:Adenosine