title: The biochemical and haemodynamic effects of adrenaline in lignocaine local anaesthetic solutions in patients having third molar surgery under general anaesthesia.
abstract: The effects of adrenaline-containing and adrenaline-free lignocaine local anaesthetic solutions injected in doses consistent with clinical practice on plasma potassium concentration, blood glucose levels and haemodynamic responses were investigated in 20 patients having third molar surgery under general anaesthesia. All patients received a standard general anaesthetic regime. Ten patients were given 4.0 ml of 2% lignocaine as an inferior dental and long buccal block during their general anaesthetic and the other 10 received 4.0 ml of 2% lignocaine containing 1:80000 adrenaline in the same manner. There were no significant differences between treatments in blood pressure or heart rate. However, there were significant differences between treatments in plasma potassium concentration and blood glucose levels.
authors.affiliation: Department of Oral Surgery, Dental School, University of Newcastle upon Tyne.
authors.forename: J G
authors.initials: JG
authors.lastname: Meechan
authors.forename: C W
authors.initials: CW
authors.lastname: Thomson
authors.forename: G S
authors.initials: GS
authors.lastname: Blair
authors.forename: M D
authors.initials: MD
authors.lastname: Rawlins
mesh_terms: D000328:Adult; D000766:Anesthesia, Dental; D000768:Anesthesia, General; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000032:analysis; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D008340:Mandibular Nerve; D008964:Molar, Third / Q000601:surgery*; D009407:Nerve Block; D011188:Potassium / Q000097:blood; D013312:Stress, Physiological / Q000503:physiopathology; D013990:Tidal Volume; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D002245:Carbon Dioxide; D008012:Lidocaine; D011188:Potassium; D004837:Epinephrine