Limbic/mesolimbic connections and the pathogenesis of schizophrenia.
The development of models of the pathogenesis of neuropsychiatric diseases that build on recent advances in chemical neuroanatomy will help to guide future research. The interconnections among limbic, basal ganglia, and cortical structures are used to form the basis of a hypothesis of the pathogenesis of schizophrenia. The adaptive capacity of subcortical dopamine systems is advanced as an explanation of the many states of the disease.
Csernansky
J G
JG
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110.
Murphy
G M
GM
Faustman
W O
WO
D006801:Humans; D008032:Limbic System / Q000473:pathology* / Q000503:physiopathology; D008959:Models, Neurological; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D012559:Schizophrenia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology