[Means and methods of non-opiate analgesia from the point of view of the concept of the adrenergic regulation of pain sensitivity].
Nonopiate aspects of analgesia are discussed in brief from the historical point of view. The existence of adrenergic mechanisms inhibiting pain responses has been proved and they were measured by different analgesimetric procedures at the level of cerebral and spinal alpha 2 and alpha 1 adrenoceptors, respectively. A comparative analysis has shown the advantages of clopheline over conventional opiate analgesics. Preliminary clinical trials have demonstrated the efficacy of antinociceptive and hemodynamic effects of clopheline (clonidine) in different pain syndromes. The prospects of clinical application of clopheline-like and other adrenopositive drugs are discussed.
Ignatov
Iu D
IuD
Zaĭtsev
A A
AA
D003000:Clonidine / Q000627:therapeutic use*; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D013566:Sympathomimetics / Q000627:therapeutic use*
D013566:Sympathomimetics; D007980:Levodopa; D003000:Clonidine
Sredstva i metody neopiatnoĭ analgezii s pozitsiĭ kontseptsii ob adrenergicheskoĭ reguliatsii bolevoĭ chuvstvitel'nosti.