Effects of a proprietary topical medication on wound healing and collagen deposition in horses.
Full-thickness skin wounds were created on the dorsum of both metacarpi in 8 horses. Three topical treatment regimens were studied. All wounds were bandaged with a nonadherent dressing, which was held in place with a snug elastic wrap. Group-A wounds were treated with a proprietary topical wound medication that consisted of a spray and an ointment. Group-B wounds were treated with the same regimen, except the putative active ingredients in the ointment were omitted. Group-C wounds were treated with a dry nonadherent bandage only. Wound dressings were changed every day and the limbs were photographed every other day until the wounds were healed. Specimens of normal skin and biopsy specimens of healed wounds were examined histologically and were assayed for hydroxyproline content. Wound healing measurements quantitated for each wound were number of days to healing, maximal wound size attained, day wound contraction commenced, day epithelium first noticed, rate of wound contraction, final wound size, and fraction of the wound that healed by contraction. The cosmetic appearance of the healed wounds was also graded. Significant differences were not noticed in hydroxyproline content, histologic appearance, or any of the wound healing measurements between treatment groups. The cosmetic appearance of healed group-A and -B wounds was significantly better than the appearance of group-C wounds. The topical treatment regimens studied neither enhanced nor inhibited wound healing in this study.
Madison
J B
JB
Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, New Bolton Center, Kennett Square 19348.
Hamir
A N
AN
Ehrlich
H P
HP
Haberman
J
J
Topkis
V
V
Villasin
J V
JV
D000287:Administration, Topical; D000336:Aerosols; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D001458:Bandages / Q000662:veterinary; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000627:therapeutic use; D002712:Chlorides / Q000008:administration & dosage / Q000627:therapeutic use; D003094:Collagen / Q000378:metabolism*; D004338:Drug Combinations; D006736:Horses / Q000293:injuries* / Q000502:physiology; D006909:Hydroxyproline / Q000032:analysis; D008276:Magnesium Hydroxide / Q000008:administration & dosage / Q000627:therapeutic use; D009824:Ointments; D011736:Pyridoxine / Q000008:administration & dosage / Q000627:therapeutic use; D012867:Skin / Q000293:injuries*; D012879:Skin Physiological Phenomena; D014801:Vitamin A / Q000008:administration & dosage / Q000627:therapeutic use; D014945:Wound Healing; D015032:Zinc / Q000008:administration & dosage / Q000627:therapeutic use; D017967:Zinc Compounds
D000336:Aerosols; D002712:Chlorides; D004338:Drug Combinations; D009824:Ointments; D017967:Zinc Compounds; D014801:Vitamin A; D000536:Aluminum Hydroxide; C016837:zinc chloride; D003094:Collagen; D002119:Calcium Carbonate; D015032:Zinc; D011736:Pyridoxine; D008276:Magnesium Hydroxide; D006909:Hydroxyproline