title: The effect of ranitidine, cimetidine or famotidine on low-dose post-prandial alcohol absorption.
abstract: Plasma alcohol concentration following oral ingestion of 0.3 g/kg of alcohol (ethyl alcohol), one hour after an evening meal, was measured in four groups of 12 healthy subjects. Each group had a control study and a repeat study after 7 days dosing with either placebo or an H2-receptor antagonist (300 mg ranitidine nocte, 800 mg cimetidine nocte, or 40 mg famotidine nocte). There was no significant difference between the control and post-dosing studies in the integrated 4-h plasma alcohol concentration, peak plasma alcohol concentration, or time to reach peak alcohol concentration. This study shows that post-prandial alcohol absorption after 0.3 g/kg of alcohol is not affected by ranitidine, cimetidine or famotidine.
authors.affiliation: University Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Fraser
authors.forename: E J
authors.initials: EJ
authors.lastname: Prewett
authors.forename: M
authors.initials: M
authors.lastname: Hudson
authors.forename: A M
authors.initials: AM
authors.lastname: Sawyerr
authors.forename: S B
authors.initials: SB
authors.lastname: Rosalki
authors.forename: R E
authors.initials: RE
authors.lastname: Pounder
mesh_terms: D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004435:Eating; D000431:Ethanol / Q000097:blood / Q000378:metabolism*; D015738:Famotidine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D011899:Ranitidine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000431:Ethanol; D015738:Famotidine; D002927:Cimetidine; D011899:Ranitidine