Prevention by interleukin-1 of intracisternally injected thyrotropin-releasing hormone (TRH)-induced gastric mucosal lesions in rats.
We have recently found that interleukin-1 (IL-1) acts in the central nervous system to potently inhibit gastric acid and pepsin secretion in rats. In the present study, we examined the effects of IL-1 on the development of gastric mucosal lesions induced by intracisternal (i.c.) thyrotropin-releasing hormone (TRH), a neuropeptide known to centrally stimulate gastric secretion. Pretreatment with i.c. injected IL-1 (10 ng/rat) significantly suppressed the severity of TRH-induced gastric erosions. On the other hand, the same dose of i.c. injected IL-1 failed to exert a cytoprotective action for the gastric mucosa against orally administered absolute ethanol. These results suggest that IL-1 has an anti-ulcer effect mainly through its inhibitory action on gastric secretion.
Okumura
T
T
Department of Internal Medicine (III), Asahikawa Medical College, Hokkaido, Japan.
Uehara
A
A
Kitamori
S
S
Okamura
K
K
Takasugi
Y
Y
Namiki
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D000431:Ethanol / Q000633:toxicity; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000633:toxicity*
D007375:Interleukin-1; D011994:Recombinant Proteins; D000431:Ethanol; D013973:Thyrotropin-Releasing Hormone