Systemic administration of acromelic acid induces selective neuron damage in the rat spinal cord.
A single systemic administration of acromelic acid A (ACRO), a novel kainate analogue (kainoid), induces a series of characteristic behavioral changes in association with selective damage of interneurons in the caudal spinal cord in adult rats. When ACRO (5 mg/kg) was systemically administered, rats displayed forced extension of hindlimbs followed by frequent cramps and generalized convulsion. Most rats died during the convulsions without neuropathological change. Two rats developed long-lasting spastic paraparesis which persisted at least 3 months. Neuropathological changes were observed only in the rats with persistent paraparesis, in which neuron damage was identified selectively in small interneurons in the lumbosacral cord. The regional difference between kainate- and ACRO-induced neuron damage suggests the existence of plural kinds of kainate receptor subtypes.
Kwak
S
S
National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, Kodaira, Tokyo, Japan.
Aizawa
H
H
Ishida
M
M
Shinozaki
H
H
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007395:Interneurons / Q000187:drug effects* / Q000473:pathology; D007608:Kainic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D007928:Lethal Dose 50; D008161:Lumbosacral Region; D008297:Male; D009128:Muscle Spasticity / Q000139:chemically induced / Q000473:pathology; D010243:Paralysis / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced; D013116:Spinal Cord / Q000187:drug effects* / Q000473:pathology
C051743:acromelic acid A; D007608:Kainic Acid