[A role of cultured bovine lens epithelial cells in the fibrinolytic system].
The release of plasminogen activators (PAs) and plasminogen activator inhibitor (PAI) from cultured bovine lens epithelial cells was investigated, in an attempt to study the effect of lens epithelial cells on the fibrin deposit and fibrinolytic process on the surface of IOL. Cultured bovine lens epithelial cells released tissue plasminogen activator (t-PA) and type 1 plasminogen activator inhibitor (PAI-1). t-PA activity was completely inhibited by PAI-1. These findings suggest that lens epithelial cells cause suppression of fibrinolysis in the anterior chamber of the eye.
Fukushima
M
M
Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ishibashi
T
T
Inomata
H
H
Sueishi
K
K
D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D004847:Epithelial Cells; D004848:Epithelium / Q000502:physiology; D005342:Fibrinolysis; D007908:Lens, Crystalline / Q000166:cytology / Q000502:physiology*; D015849:Plasminogen Inactivators / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000378:metabolism
D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator