title: Lack of a relationship between the polymorphism of debrisoquine oxidation and lung cancer.
abstract: 1. Determination of debrisoquine oxidation phenotype was carried out in 119 healthy subjects, 135 patients with chronic bronchitis and 153 patients with lung cancer, all of Caucasian origin. 2. A non-Gaussian distribution of the log D/HD ratio was observed in the three groups. 3. Assuming an antimode of 1.12, the proportion of PMs was found to be 6.7% in healthy subjects, 8.9% in chronic bronchitics and 6.5% in patients with lung cancer. These differences were not significant. 4. The presence of a lung tumour itself had no influence on phenotype in a group of 14 patients who were phenotyped before and after surgery. 5. We conclude that a link between debrisoquine phenotype and lung cancer is unlikely.
authors.affiliation: Laboratoire hospitalo-universitaire de Pharmacologie, Creteil, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Duche
authors.forename: C
authors.initials: C
authors.lastname: Joanne
authors.forename: J
authors.initials: J
authors.lastname: Barre
authors.forename: H
authors.initials: H
authors.lastname: de Cremoux
authors.forename: J C
authors.initials: JC
authors.lastname: Dalphin
authors.forename: A
authors.initials: A
authors.lastname: Depierre
authors.forename: P
authors.initials: P
authors.lastname: Brochard
authors.forename: J P
authors.initials: JP
authors.lastname: Tillement
authors.forename: P
authors.initials: P
authors.lastname: Bechtel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001991:Bronchitis / Q000235:genetics; D002908:Chronic Disease; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D012907:Smoking
chemical_list: D003647:Debrisoquin