title: Reduced expression of HLA-DP antigens on PWM stimulated T lymphocytes in patients suffering from psoriasis vulgaris.
abstract: 24 psoriasis vulgaris patients were investigated for the expression of class II HLA antigens on the surface of PWM-stimulated T lymphocytes. The percentage of the expression of HLA-DP antigens ranged from 50.1% to 82.6% compared to a 100% level in healthy controls (p less than 0.005). No significant differences in the expression of HLA-DR antigens were observed. A higher frequency of some HLA antigens was found in the group of patients studied: B13 - 23.1%/6.2%, B 17 - 15.4%/7.1%, and Dw7 - 59.4%/15.8%.
authors.affiliation: Faculty of Medicine, Comenius University Bratislava, Czechoslovakia.
authors.forename: M
authors.initials: M
authors.lastname: Buc
authors.forename: H
authors.initials: H
authors.lastname: Munozová
authors.forename: G
authors.initials: G
authors.lastname: Russ
authors.forename: B
authors.initials: B
authors.lastname: Busová
authors.forename: F
authors.initials: F
authors.lastname: Vlcek
authors.forename: J
authors.initials: J
authors.lastname: Rovenský
mesh_terms: D003208:Concanavalin A / Q000494:pharmacology; D015870:Gene Expression; D006682:HLA-DP Antigens / Q000096:biosynthesis*; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D011565:Psoriasis / Q000276:immunology*; D011863:Radioimmunoassay; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D006682:HLA-DP Antigens; D006684:HLA-DR Antigens; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A