Cell kinetics of gastrointestinal tumors after different nutritional regimens. A preliminary report.
Forty-four cases of different untreated gastrointestinal tumors were studied with regard to cell kinetic activity. As a pilot experiment, we also determined the 3H-TdR Labeling Index (LI) in 28 patients in basal conditions and after 15 days of nutritional manipulation with prevalently lipid-based or glucose-based feeding to ascertain whether selective nutritional regimens could affect tumor proliferation. Preliminary results from this study indicate that a kinetic perturbation is induced in tumor cells by nutritional manipulation. Lipid-based feeding seems to produce effects similar to those of chemical or physical anticancer agents, thus suggesting a possible supporting role of nutritional manipulation in cancer treatment strategy.
Franchi
F
F
Third Institute of Clinical Medicine, Oncology Unit, University La Sapienza, Rome, Italy.
Rossi-Fanelli
F
F
Seminara
P
P
Cascino
A
A
Barone
C
C
Scucchi
L
L
D000368:Aged; D002455:Cell Division / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000178:diet therapy / Q000473:pathology; D004067:Digestive System Neoplasms / Q000178:diet therapy* / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000178:diet therapy / Q000473:pathology; D005260:Female; D005526:Food, Formulated; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D013274:Stomach Neoplasms / Q000178:diet therapy / Q000473:pathology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D008055:Lipids; D014316:Tritium; D005947:Glucose; D013936:Thymidine