Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse.
Molecular characterization of a radiation-induced agouti (a)-locus mutation has resulted in the isolation of a segment of DNA that maps at or near the a locus on chromosome 2 in the mouse. This region of DNA is deleted in several radiation- or chemical-induced homozygous-lethal a-locus mutations and is associated with specific DNA structural alterations in two viable a-locus mutations. We propose that DNA probes from this region of chromosome 2 will be useful for ultimately characterizing the individual gene or genes associated with a-locus function.
Bultman
S J
SJ
Biology Division, Oak Ridge National Laboratory, TN.
Russell
L B
LB
Gutierrez-Espeleta
G A
GA
Woychik
R P
RP
D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002872:Chromosome Deletion; D007446:Chromosome Inversion; D003001:Cloning, Molecular; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D015183:Restriction Mapping; D012880:Skin Pigmentation