Ultrastructural examination of experimentally induced premalignant lesions.
Lesions induced in hamster cheek pouch using dimethylbenz(alpha)anthracene were studied by transmission electron microscopy and compared with normal tissue. Features regarded as suggestive of progression towards malignancy were: increased numbers of membrane-bound vesicles in basal cells, gaps in the lamina densa associated with widening of the lamina lucida and an irregular epithelial-connective tissue junction, the presence of cerebriform cells and frequent close association of 2 or more intra-epithelial cells (lymphocytes, cerebriform cells, Langerhans cells).
Ferguson
J W
JW
Department of Oral Medicine and Oral Surgery, University of Otago, Dunedin, New Zealand.
McMillan
M D
MD
Smillie
A C
AC
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000648:ultrastructure; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D002610:Cheek; D006224:Cricetinae; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D006965:Hyperplasia; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D009061:Mouth Mucosa / Q000098:blood supply / Q000648:ultrastructure*; D009062:Mouth Neoplasms / Q000098:blood supply / Q000648:ultrastructure*; D015388:Organelles / Q000187:drug effects / Q000648:ultrastructure; D011230:Precancerous Conditions / Q000098:blood supply / Q000648:ultrastructure*
D015127:9,10-Dimethyl-1,2-benzanthracene