title: The effects of interleukin-2 on bone marrow engraftment in a murine model.
abstract: Strategies have been developed to rid bone marrow of microscopic tumor prior to infusion in the autologous bone marrow transplant setting. We have previously demonstrated that recombinant human interleukin-2 (IL-2) is effective in such an experimental setting involving a methylcholanthrene-induced fibrosarcoma in mice. The purpose of the current work was to determine whether IL-2 treatment after, or before and after bone marrow transplantation would influence bone marrow engraftment or degree of hematologic reconstitution. We found that stem cell number (CFU-S) and posttransplant marrow cellularity were comparable in IL-2-treated or saline-treated mice. Furthermore, after engraftment, marrow stem cell and myeloid progenitor cell numbers were greater in the IL-2 treatment group. These results suggest that IL-2 will prove to be safe when administered in bone marrow transplant patients.
authors.affiliation: Department of Medicine, University of Wisconsin-Madison 53706.
authors.forename: S P
authors.initials: SP
authors.lastname: Ho
authors.forename: G R
authors.initials: GR
authors.lastname: Hafez
authors.forename: W B
authors.initials: WB
authors.lastname: Ershler
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology / Q000502:physiology*; D003114:Colony-Forming Units Assay; D005260:Female; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D007700:Kinetics; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D011994:Recombinant Proteins / Q000494:pharmacology*
chemical_list: D007376:Interleukin-2; D011994:Recombinant Proteins