title: A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned taste aversion.
abstract: The conditioned taste aversion (CTA) paradigm and microdialysis were used to determine if extracellular dopamine in the nucleus accumbens is related to the reward value of a stimulus. Intraorally applied saccharin caused a 37% increase in DA in naive rats and a 40% decrease in subjects with a CTA to this taste. These results suggest that accumbens DA is not just a function of arousal but is related to stimulus reward.
authors.affiliation: Department of Psychology, Princeton University, NJ 08544-1010.
authors.forename: G P
authors.initials: GP
authors.lastname: Mark
authors.forename: D S
authors.initials: DS
authors.lastname: Blander
authors.forename: B G
authors.initials: BG
authors.lastname: Hoebel
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003213:Conditioning, Psychological; D004298:Dopamine / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism*; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012439:Saccharin / Q000494:pharmacology; D013268:Stimulation, Chemical; D013649:Taste / Q000502:physiology*
chemical_list: D012439:Saccharin; D004298:Dopamine