[Experimental study of the effects of amiridin and tacrine on learning and memory].
The authors studied the influence of amiridin and tacrine on learning and memory in mice and rat by passive avoidance conditioning test at norm and under scopolamine induced amnesia as well as of their effect on acetylcholine esterase (AChE) activity in brain cortex homogenates. Amiridin in doses 0.1 and 0.2 mg/kg showed a beneficial action on conditioning in untreated animals, its effect being comparable with that of piracetam. Tacrine was ineffective. In scopolamine treated animals amiridin and tacrine showed anti-amnestic action at dose of 0.1 mg/kg which was found ineffective with respect to AChE activity. The data suggests that the ameliorating effect of amiridin and tacrine on cognitive abilities in patients with senile dementia is not related their anticholinesterase properties.
Burov
Iu V
IuV
Robakidze
T N
TN
Kadysheva
L V
LV
Sukhanova
S A
SA
D000110:Acetylcholinesterase / Q000032:analysis; D000634:Aminoquinolines / Q000494:pharmacology* / Q000627:therapeutic use; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors; D003704:Dementia / Q000188:drug therapy / Q000201:enzymology; D066298:In Vitro Techniques; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012601:Scopolamine; D013619:Tacrine / Q000494:pharmacology*
D000634:Aminoquinolines; D002800:Cholinesterase Inhibitors; D011619:Psychotropic Drugs; D013619:Tacrine; C049860:amiridine; D012601:Scopolamine; D000110:Acetylcholinesterase
Eksperimental'noe izuchenie vliianiia amiridina i takrina na obuchenie i pamiat'.