[The genetic basis of suppression of tumors and metastases in Drosophila and man].
The first causal relations between recessive gene mutation and malignancies were detected in a fly (Drosophila melanogaster). This is a recessive-lethal heredity. Tumour suppression was demonstrated in mouse cell hybrids in the late sixties. Tumour suppressor antigens are developed recently for Wilms tumour, retinoblastomas and colorectal cancer.
Gateff
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Institut für Genetik, Johannes-Gutenberg-Universität Mainz.
D000818:Animals; D004331:Drosophila melanogaster; D005804:Genes, Lethal; D005808:Genes, Recessive; D016147:Genes, Tumor Suppressor; D006801:Humans; D009154:Mutation; D009362:Neoplasm Metastasis / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D009374:Neoplasms, Experimental / Q000235:genetics*
Genetische Grundlagen der Tumor- und Metastasensuppression bei Drosophila und Mensch.