Mitochondrial uptake of bridged bis-methylpyridinium aldoximes and induction of the "petite" phenotype in yeast.
The 3,3'-[omega,omega'-alkanediylbis(oxy)]bis[2- (hydroxyimino)methyl]-1-methylpyridinium derivatives bearing a linking chain of 4, 5 and 6 methylene groups are accumulated in mitochondria with increasing efficiency under the effect of the electrical potential. Accumulation does not take place with derivatives carrying a 2 and 3 methylene-long linking chain. The uptake process is saturable. The efficiency of the various derivatives to induce the "petite" phenotype in yeast reflects the uptake rate observed with purified mitochondria.
Dodin
G
G
Institut de Topologie et de Dynamique des Systèmes, Université Paris 7, CNRS URA 34, France.
Averbeck
D
D
Demerseman
P
P
Nocentini
S
S
Dupont
J
J
D004249:DNA Damage; D004272:DNA, Mitochondrial; D006838:Hydrocarbons / Q000737:chemistry; D007700:Kinetics; D008564:Membrane Potentials; D008928:Mitochondria / Q000378:metabolism*; D010101:Oxygen Consumption; D010641:Phenotype; D011726:Pyridinium Compounds / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*
D004272:DNA, Mitochondrial; D006838:Hydrocarbons; D011726:Pyridinium Compounds