[Effect of the calcium channel blockers on rotation induced by apomorphine and amphetamine in rats lesioned with 6-hydroxydopamine].
We have studied the effects of calcium channel blockers cinarizine, flunarizine, nicardipine, nifedipine, verapamil and diltiazem on the motor anomalies which can be found in rats with unilateral nigrostriated lesion due to 6-OH-DA. All of them reduce rotation induced by apomorphine according to this order: nifedipine greater than nicardipine greater than diltiazem greater than flunarizine greater than verapamil greater than cinarizine. No effects on rotation induced by amphetamine have been observed. Our data suggest that calcium channel blockers cause dopamine receptor blockade but they do not modify the calcium-non-depending releasing of dopamine induced by amphetamine.
Tabernero
C
C
Departamento de Investigación, Centro Ramón y Cajal Madrid.
Pardo
B
B
García de Yébenes
J
J
D000661:Amphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D006892:Hydroxydopamines; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*; D013563:Sympathectomy, Chemical
D002121:Calcium Channel Blockers; D006892:Hydroxydopamines; D016627:Oxidopamine; D000661:Amphetamine; D001058:Apomorphine
Efecto de los bloqueantes de canales de calcio sobre la rotación inducida por apomorfina y anfetamina en ratas lesionadas con 6-OH-DA.