[Identification and localization on chromosome 1 of a gene controlling the occurrence of periinsulitis in NOD diabetic mice].
Diabetic NOD (Non Obese Diabetic) mice show early pancreatic infiltration of mononuclear cells around Langerhans islets (periinsulitis). Study of (NOD x C57BL/6) F1 and F2 mice reveals that periinsulitis is constantly associated with a similar infiltration of salivary glands (sialitis) and is controlled by a dominant susceptibility locus. Segregation analysis of periinsulitis and microsatellite DNA markers indicates that the gene controlling periinsulitis maps to chromosome 1, close to the Bcl-2 locus.
Garchon
H J
HJ
I.N.S.E.R.M. U25, Hôpital Necker, Paris.
Bedossa
P
P
Eloy
L
L
Bach
J F
JF
D000818:Animals; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003921:Diabetes Mellitus, Experimental / Q000235:genetics; D006801:Humans; D007515:Islets of Langerhans; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D010195:Pancreatitis / Q000150:complications / Q000235:genetics*; D012793:Sialadenitis / Q000150:complications
Identification et localisation sur le chromosome 1 d'un gène contrôlant la survenue de la périinsulite chez la souris diabétique NOD.