[The effect of glibenclamide on the spontaneous evolution of genetically determined diabetes mellitus in C57BL/KsJY db+/+db mice].
The study was carried out on 25 mice of the mutant C57BL/KsJY line carrying the autosomal-recessive gene db (diabetes) in the homozygous state with basal normo- and hyperglycemia by the beginning of the treatment with glybenclamide (the latent and manifest stages of insulin-independent diabetes mellitus). It was found that long-term oral administration of the drug in the therapeutic dose (20 micrograms per mice a day for 3-3.5 months) enhanced the genetically determined disturbances of glucose homeostasis and the insulin-producing apparatus of the pancreas irrespective of the stage of spontaneous diabetes genesis. The development of the organ-specific autoimmune reactions directed to antigens of the pancreatic islands was found.
Poltorak
V V
VV
Gladkikh
A I
AI
Blokh
K O
KO
Brindak
O I
OI
Berestovskaia
E V
EV
Tur
M I
MI
D000818:Animals; D001323:Autoantibodies / Q000097:blood; D015551:Autoimmunity / Q000187:drug effects / Q000276:immunology; D001786:Blood Glucose / Q000032:analysis; D004247:DNA / Q000276:immunology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D004198:Disease Susceptibility / Q000097:blood / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D005260:Female; D020022:Genetic Predisposition to Disease; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000627:therapeutic use*; D006720:Homozygote; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008817:Mice, Mutant Strains / Q000235:genetics*; D013997:Time Factors
D001323:Autoantibodies; D001786:Blood Glucose; D004247:DNA; D005905:Glyburide
Vliianie glibenklamida na spontannuiu évoliutsiiu geneticheski determinirovannogo sakharnogo diabeta u mysheĭ linii C57BL/KsJY db+/+db.