Organic anion transport study in mutant rats with autosomal recessive conjugated hyperbilirubinemia.
The EHBR is a mutant rat strain with congenital conjugated hyperbilirubinemia bred from a Sprague-Dawley rat. Transport of conjugated bilirubin, indocyanine green, and tetrabromosulfophtalein from liver to bile is severely impaired in these rats. Serum bilirubin amounts to 6.0 +/- 0.05 mg/dl (n = 4) in adult rats, with 97% conjugates. The bile flow is reduced to about 65% of the control group, whereas total bile acid in 10-min bile samples is similar. Liver histology of 10 week-old rats revealed neither intracellular pigmentation nor architectural abnormalities.
Kurisu
H
H
Third Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Kamisaka
K
K
Koyo
T
T
Yamasuge
S
S
Igarashi
H
H
Maezawa
H
H
Uesugi
T
T
Tagaya
O
O
D000818:Animals; D001646:Bile / Q000737:chemistry; D001647:Bile Acids and Salts / Q000032:analysis; D001663:Bilirubin / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D006933:Hyperbilirubinemia, Hereditary / Q000378:metabolism*; D007208:Indocyanine Green / Q000493:pharmacokinetics; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D013448:Sulfobromophthalein / Q000493:pharmacokinetics
D001647:Bile Acids and Salts; D013448:Sulfobromophthalein; C016266:bilirubin glucuronate; D007208:Indocyanine Green; D001663:Bilirubin