title: Intraarterial cisplatin in the management of stage IIB osteosarcoma in the pediatric and adolescent age group.
abstract: Sixty patients with extremity osteosarcoma were treated with intraarterial cisplatin. This was followed by surgical resection (amputation or limb salvage) and postoperative adjuvant chemotherapy utilizing two different protocols. Seventy-five percent of patients achieved an initial response. Overall disease-free survival was 58%. The number of patients treated with limb-salvage surgery gradually increased to the extent that 80% of newly-registered patients achieved a response and were subjected to limb salvage. Disease-free survival was 48% in amputation and 68% in limb salvage. The only factors found to have prognostic significance in determining disease-free survival were extent of tumor destruction induced by preoperative chemotherapy and tumor size.
authors.affiliation: Division of Pediatrics, University of Texas M.D. Anderson Caner Center, Houston 77030.
authors.forename: N
authors.initials: N
authors.lastname: Jaffe
authors.forename: D
authors.initials: D
authors.lastname: Smith
authors.forename: M R
authors.initials: MR
authors.lastname: Jaffe
authors.forename: M
authors.initials: M
authors.lastname: Hudson
authors.forename: H
authors.initials: H
authors.lastname: Carrasco
authors.forename: S
authors.initials: S
authors.lastname: Wallace
authors.forename: A K
authors.initials: AK
authors.lastname: Raymond
authors.forename: A
authors.initials: A
authors.lastname: Ayala
authors.forename: J
authors.initials: J
authors.lastname: Murray
authors.forename: R
authors.initials: R
authors.lastname: Robertson
mesh_terms: D000293:Adolescent; D000671:Amputation, Surgical / Q000592:standards; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D002985:Clinical Protocols / Q000592:standards; D003131:Combined Modality Therapy; D006801:Humans; D007269:Injections, Intra-Arterial; D015993:Life Tables; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D010027:Osteotomy / Q000592:standards; D011300:Preoperative Care / Q000379:methods / Q000592:standards; D011379:Prognosis; D012074:Remission Induction / Q000379:methods; D015996:Survival Rate; D013781:Texas / Q000453:epidemiology
chemical_list: D002945:Cisplatin