title: Influence of insulin and biogenic amines on the division of Chang liver cells after primary exposure (imprinting) and repeated treatments.
abstract: Cells of the Chang liver line responded differently to insulin and histamine exposure and re-exposure after five pretreatments. The mitotic index showed a considerable relative decrease 72 h after the last pretreatment. The response to serotonin did not differ between pretreatment and re-exposure. The effect of insulin and of biogenic amines was positive at the primary exposure and negative 72 h after repeated pretreatments.
authors.affiliation: Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Csaba
authors.forename: O
authors.initials: O
authors.lastname: Török
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004347:Drug Interactions; D006632:Histamine / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008940:Mitotic Index / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*
chemical_list: D007328:Insulin; D012701:Serotonin; D006632:Histamine