Analytical goals for interference.
Objective analytical goals for interference in clinical biochemical methods have not yet been advocated. We propose that, since total analytical error is ideally less than half the within-subject biological coefficient of variation (CVI), the maximum allowable systematic error produced by an interferent (I) is: I less than CVI-(1.96 CVA + SE), where CVA is the relevant experimental analytical imprecision and SE is the systematic error. Such a goal may be applicable also to non-specificity, matrix effects and carryover.
Fuentes-Arderiu
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Servei de Bioquímica Clínica, Hospital Prínceps d'Espanya, Barcelona, Spain.
Fraser
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CG
D002623:Chemistry Techniques, Analytical / Q000592:standards*; D002624:Chemistry, Clinical / Q000592:standards*; D003627:Data Interpretation, Statistical; D005188:False Negative Reactions; D005189:False Positive Reactions; D012680:Sensitivity and Specificity