[The anti-ischemic properties of verapamil and its effect on myocardial functional potentials in coronary artery occlusion].
The effect of verapamil on the functional state of the ischemic myocardium, the myocardial tolerance to ischemia and the processes of urgent adaptation of the heart in the coronary artery occlusion was investigated in the experiments on anesthetized open-chest cats. Verapamil was shown to exert the dose-dependent anti-ischemic action, to increase the myocardial tolerance to ischemia, to suppress the response to the physiological saline infusion and not to change adrenoreactivity of the ischemic myocardium at the coronary artery compression.
Paperno
A A
AA
Kovalev
G V
GV
Gurbanov
K G
KG
D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002415:Cats; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D014700:Verapamil
Antiishemicheskie svoĭstva verapamila i ego vliianie na funktsional'nye vozmozhnosti miokarda pri okkliuzii koronarnoĭ arterii.