title: Recurrent haemolytic uraemic syndrome in a transplant recipient on orthoclone (OKT 3).
abstract: Recurrence of haemolytic-uraemic syndrome (HUS) after renal transplantation may occur in both cyclosporin A (CyA) and non-CyA-treated patients, and in patients receiving anti-lymphocyte globulin. We report a case of recurrent HUS in an 8-year-old boy who received Orthoclone (OKT3) combined with prednisolone and azathioprine therapy on receipt of his first cadaveric renal allograft. Despite avoidance of CyA therapy irreversible HUS occurred.
authors.affiliation: Department of Nephrology, Royal Melbourne Hospital, Victoria, Australia.
authors.forename: D J
authors.initials: DJ
authors.lastname: Goodman
authors.forename: R G
authors.initials: RG
authors.lastname: Walker
authors.forename: I E
authors.initials: IE
authors.lastname: Birchall
authors.forename: A J
authors.initials: AJ
authors.lastname: d'Apice
authors.forename: H R
authors.initials: HR
authors.lastname: Powell
authors.forename: P
authors.initials: P
authors.lastname: Kincaid-Smith
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D001379:Azathioprine / Q000009:adverse effects; D002648:Child; D004359:Drug Therapy, Combination; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced*; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008297:Male; D016853:Muromonab-CD3; D011239:Prednisolone / Q000009:adverse effects; D012008:Recurrence
chemical_list: D000911:Antibodies, Monoclonal; D016853:Muromonab-CD3; D011239:Prednisolone; D001379:Azathioprine