Complement activation during bypass in acquired C1 esterase inhibitor deficiency.
Serial complement estimations during cardiopulmonary bypass are reported in a patient with acquired C1 esterase inhibitor deficiency. Although the extent of classic and alternative pathway activation appeared appropriate, exaggerated common pathway activation with massive increase in the C3d:C3 ratio occurred. A fatal hemostatic disorder, pulmonary edema, and circulatory collapse ensued despite prophylaxis and therapy.
Bonser
R S
RS
Brompton Hospital, London, United Kingdom.
Dave
J
J
Morgan
J
J
Morgan
C
C
Davies
E
E
Taylor
P
P
Gaya
H
H
John
L
L
Paneth
M
M
Vergani
D
D
D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D003167:Complement Activation / Q000276:immunology*; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency*; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D012307:Risk Factors
D003174:Complement C1 Inactivator Proteins