[The effect of new antimicrobial preparations used in combination with complete gnotobiotic isolation on the survivability and intestinal microflora of total-body irradiated mice].
The aim of these investigations was the study of the effect of different antimicrobial preparations on the survival rate and intestinal microflora of mice with experimental acute radiation sickness. These investigations revealed that the survival rate of the animals increased 3.1 times with the use of Supramycin, 2.4 times with the use of Tacef and 1.6 times with the use of Spizef and Pen-bristol. The study of the influence of these preparations on the intestinal microflora revealed that Spizef not only decreased the number of opportunistic microorganisms, but also led to a sharp drop in the level of lactobacteria. The use of Pen-bristol and Tacef led to practically complete elimination of enterobacteria enterococci, staphylococci, as well as lactobacteria. Supramycin essentially suppressed the number of opportunistic microorganisms and did not affect the level of lactobacteria. This was probably the cause of the highest effectiveness of Supramycin in comparison with Tacef, Spizef and Pen-bristol.
Romanchuk
L A
LA
Elizbarashvili
D A
DA
Ginodman
G A
GA
Korshunov
V M
VM
D000208:Acute Disease; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003666:Decontamination; D004353:Drug Evaluation, Preclinical; D005856:Germ-Free Life / Q000187:drug effects* / Q000528:radiation effects*; D007422:Intestines / Q000187:drug effects / Q000382:microbiology* / Q000528:radiation effects; D051379:Mice; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D000890:Anti-Infective Agents
Izuchenie vliianiia novykh antimikrobnykh preparatov, primeniaemykh v komplekse s obshcheĭ gnotobiologicheskoĭ izoliatsieĭ, na vyzhivaemost' i mikrofloru kishechnika total'no obluchennykh mysheĭ.