[Interaction of carbonic acid reamination and oxidation processes at various functional states of tissue].
The metabolic pathways of generation and oxidation of di- and tricarboxylic acids in mitochondria differ under the resting state and during the stimulation of energy metabolism coupled with the activation of physiological functions. The contribution of amino acids to the respiration via glutamate transamination is greater during stimulation of energy metabolism than in the resting state. This may account for the increased contribution to mitochondrial respiration of succinate, the most powerful energy source among TCA substrates. The increase of succinate in the respiration is especially apparent after addition of physiological concentrations of succinate (0.3-1.0 mM). The relationship between transamination and respiration was observed during short-term experiments with mitochondria preserving their native structure. This interaction was lost in damaged mitochondria under conditions of TCA discovery.
Kondrashova
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MN
D000586:Amination; D000818:Animals; D002255:Carbonic Acid / Q000737:chemistry*; D004734:Energy Metabolism; D008928:Mitochondria / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism
D002255:Carbonic Acid; D010100:Oxygen
Vzaimodeĭstvie protsessov pereaminirovaniia i okisleniia karbonovykh kislot pri raznykh funktsional'nykh sostoianiiakh tkani.