title: Tranexamic acid treatment of hemothorax in two patients with malignant mesothelioma.
abstract: Patients with malignant mesothelioma may present with hemothorax. We used a combination of oral and intrapleural tranexamic acid to treat two patients with this severe complication. Initiation of treatment with this potent anti-fibrinolytic drug resulted in rapid reduction of bleeding and of transfusion requirements.
authors.affiliation: Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: W A
authors.initials: WA
authors.lastname: De Boer
authors.forename: M G
authors.initials: MG
authors.lastname: Koolen
authors.forename: C M
authors.initials: CM
authors.lastname: Roos
authors.forename: J W
authors.initials: JW
authors.lastname: Ten Cate
mesh_terms: D000368:Aged; D001777:Blood Coagulation; D005260:Female; D005342:Fibrinolysis; D006491:Hemothorax / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000150:complications*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000150:complications*; D014148:Tranexamic Acid / Q000627:therapeutic use*
chemical_list: D014148:Tranexamic Acid