[The production and characteristics of liposomes bearing interferon antibodies on their surfaces].
Liposomes carrying anti-interferon antibodies 5A6 on their surface were prepared from the mixture of lecithin and cholesterol. The binding of antibodies with the liposomal membrane was achieved by their modification with palmitic acid molecules in an amount of 3-4 molecules per vesicle. Antibodies on the liposomal surface were shown to retain their antigenic specificity, but the amount of the antigen bound by them was less than a half of the possible maximum amount. Double immune complexes could be formed on bound antibodies, but the number of such complexes was relatively small. The causes of a decrease in the sorption of interferon and the formation of immune complexes are discussed.
Cherniavskiĭ
V A
VA
Zibrin
S V
SV
Lebedev
A D
AD
D000327:Adsorption; D000906:Antibodies / Q000032:analysis* / Q000276:immunology; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex / Q000276:immunology; D001666:Binding Sites, Antibody / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D007370:Interferon Type I / Q000276:immunology*; D007457:Iodine Radioisotopes; D008081:Liposomes / Q000276:immunology / Q000302:isolation & purification*; D013499:Surface Properties
D000906:Antibodies; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007370:Interferon Type I; D007457:Iodine Radioisotopes; D008081:Liposomes
Poluchenie i kharakteristika liposom, nesushchikh na svoeĭ poverkhnosti antitela k interferonu.