[Immunosuppression therapy with cyclosporin in inflammatory bowel disease: preliminary experience].
Three patients afflicted with inflammatory bowel disease (1 UC, 1 Crohn's disease, 1 non-filiated colitis), who did not respond to the aggressive treatment from Oxford (3) were treated with immunosuppression therapy with cyclosporin. The dosage was 5-7 mg/day, to obtain seric levels (RIA) between 100-125 ng/ml during 3 months. All patients showed complete remission which was maintained for 6 months after the halt in treatment in the cases of the UC and non-filiated colitis. Parameters of cholestasis appeared with a transient increase of transaminase levels in 1 patient. Another patient suffered a pericarditis sicca which may not necessarily be related to the treatment.
Martínez Salmeron
J E
JE
Servicio de Aparato Digestivo, C. S. Virgen de las Nieves, Granada.
Nogueras López
F
F
de Sola Earle
C
C
Rodrigo Moreno
M
M
Lacarcel Fernández
E
E
D000328:Adult; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D008297:Male
D003524:Cyclosporins
Tratamiento inmunosupresor con ciclosporina en la enfermedad inflamatoria intestinal (EII): experiencia preliminar.