Hemizygous deletion of the 3' end of the RB1 gene in a case of Philadelphia positive-acute lymphoblastic leukemia.
In order to address a possible role for the human retinoblastoma susceptibility (RB1) gene in hematopoietic malignancies, 34 cases of different types of leukemia without chromosomal abnormalities at band 13q14 were analyzed by Southern blot hybridization. A large deletion encompassing exon 18-27 was detected in one case of Ph1 positive-acute lymphoblastic leukemia. Interestingly, this deletion appeared to be similar to another deletion recently reported in a leukemic cell line derived from a T-ALL. No rearrangement was detected in all other leukemias.
Hillion
J
J
Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
Larsen
C J
CJ
Berger
R
R
D000328:Adult; D015139:Blotting, Southern; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13; D015342:DNA Probes; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D016160:Retinoblastoma Protein / Q000235:genetics*
D015342:DNA Probes; D016160:Retinoblastoma Protein