Aortic root blood flow increases after pancuronium in neonates with hyaline membrane disease.
OBJECTIVE
To determine the effects of muscle paralysis on aortic root blood flow in preterm infants with hyaline membrane disease.


METHODS
Each patient served as his/her own control in a prospectively controlled trial.


METHODS
Neonatal ICU in a university hospital.


METHODS
Ten ventilator-dependent preterm infants weighing 800 to 2820 g, 0 to 8 days of age, with hyaline membrane disease and seven control patients.


METHODS
Noninvasive measurement of aortic root blood flow by Doppler echocardiography 30 min before and 60 min after respiratory paralysis with 0.1 to 0.5 mg/kg of iv pancuronium, or following ventilator changes in control subjects.


RESULTS
Mean aortic root blood flow increased significantly (p less than .001), from 212 to 276 mL/min.kg, accompanied by significant increases in stroke volume and heart rate.


CONCLUSIONS
Pancuronium bromide may have a direct beneficial effect on the circulation of preterm infants with hyaline membrane disease.
Costakos
D T
DT
Department of Pediatrics, New York Hospital-Cornell Medical Center, NY 10021.
Blackwell
C E
CE
Krauss
A N
AN
Eisen
C
C
Violaris
K
K
Wiercinski
A E
AE
Auld
P A
PA
D001011:Aorta / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006819:Hyaline Membrane Disease / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007231:Infant, Newborn; D010100:Oxygen / Q000097:blood; D010197:Pancuronium / Q000627:therapeutic use*; D011446:Prospective Studies; D014655:Vascular Resistance / Q000187:drug effects
D002245:Carbon Dioxide; D010197:Pancuronium; D010100:Oxygen