[Luminol and lucigenin-dependent chemiluminescence in 6-hydroxydopamine auto-oxidation].
It was shown by the methods of luminol- and lucigenin-dependent chemiluminescence that 6-hydroxydopamine 6-ONDA autooxidation is accompanied by generation of superoxide anion-radical which can further react with next 6-ONDA molecule. This fact is based on the observations that intensities of luminol- and lucigenin-dependent chemiluminescence during 6-ONDA autooxidation was increased in aprotonic aqueous solutions (with the decreasing of pH) and was extremely depended on 6-ONDA concentration. The obtained data allows to suggest that one of the possible mechanisms of 6-ONDA neurotoxic action includes the generation of superoxide, whose dismutation to hydrogen peroxide in the presence of transient valency ions gives rise to HO.
Klimshina
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D000166:Acridines; D006892:Hydroxydopamines; D007202:Indicators and Reagents; D015227:Lipid Peroxidation; D008163:Luminescent Measurements; D008165:Luminol; D010084:Oxidation-Reduction
D000166:Acridines; D006892:Hydroxydopamines; D007202:Indicators and Reagents; C033472:10,10'-dimethyl-9,9'-biacridinium; D008165:Luminol
Liuminol- i liutsigeninzavisimaia khemliuminestsentsiia pri avtookislenii 6-oksidofamina.