title: Tracheal granulation tissue. A study of bacteriology.
abstract: We prospectively examined 19 patients (21 laryngotracheal reconstructions) over a 6-month period to evaluate the bacteriology of granulation tissue present at the time of Teflon stent removal and at the first laryngoscopy several weeks later. The most frequently recovered isolates were viridans streptococci, Pseudomonas aeruginosa, nonhemolytic Streptococcus, and Staphylococcus aureus. All but one positive culture were polymicrobial. The amount of tissue did not correlate with the duration of stenting and the amount of granulation tissue and number of organisms decreased after stent removal. Further prospective study of the most appropriate antimicrobial therapy is needed.
authors.affiliation: Department of Pediatric Otolaryngology and Maxillofacial Surgery, Children's Hospital Medical Center, Cincinnati, OH 45229-2899.
authors.forename: B H
authors.initials: BH
authors.lastname: Matt
authors.forename: C M
authors.initials: CM
authors.lastname: Myer
authors.forename: C J
authors.initials: CJ
authors.lastname: Harrison
authors.forename: S F
authors.initials: SF
authors.lastname: Reising
authors.forename: R T
authors.initials: RT
authors.lastname: Cotton
mesh_terms: D001419:Bacteria / Q000302:isolation & purification*; D002433:Cefaclor / Q000008:administration & dosage / Q000627:therapeutic use; D002512:Cephalothin / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006097:Granulation Tissue / Q000382:microbiology*; D006190:Haemophilus / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007830:Larynx / Q000601:surgery; D008297:Male; D011446:Prospective Studies; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000302:isolation & purification; D015607:Stents; D013291:Streptococcus / Q000302:isolation & purification; D013997:Time Factors; D014132:Trachea / Q000382:microbiology* / Q000601:surgery; D014140:Tracheotomy / Q000295:instrumentation / Q000379:methods
chemical_list: D002433:Cefaclor; D002512:Cephalothin