Effect of platelet activating factor on reticuloendothelial system function.
The effect of platelet activating factor (PAF) injections on the uptake of 99mTc-SC (99mTc-SC (99mTc-sulphur colloid) was determined in vivo. PAF (2 micrograms) injected intravenously into unanaesthetized, unrestrained rats was associated with the development of lesions in the small intestine and alteration of 99mTc-SC uptake in vivo. 99mTc-SC uptake into the lung was increased while spleen uptake was decreased. Pretreatment of the animals with a PAF antagonist, SRI-64-441, prevented the intestinal lesions and alterations of 99mTc-SC uptake. Macrophages, isolated from lung lavage of the PAF-treated rats, demonstrated a decreased generation of hydrogen peroxide in vitro. The present results suggest that, in addition to its other effects on the immune system, PAF can also alter the in vivo phagocytic activity of the reticuloendothelial system in the rat.
Trop
M
M
Department of Pediatrics, Massachusetts General Hospital, Boston.
Schiffrin
E J
EJ
Carter
E A
EA
D000818:Animals; D002056:Burns / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D002432:Cecum / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D007275:Injections, Intravenous; D007421:Intestine, Small / Q000276:immunology / Q000473:pathology; D012157:Mononuclear Phagocyte System / Q000502:physiology*; D009336:Necrosis; D010972:Platelet Activating Factor / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000276:immunology / Q000473:pathology; D013671:Technetium Tc 99m Sulfur Colloid
D010972:Platelet Activating Factor; D013671:Technetium Tc 99m Sulfur Colloid