title: Alprazolam and oxazepam in the treatment of anxious out-patients with depressive symptoms: a double-blind multicenter study.
abstract: In a four-week double-blind study comparing alprazolam with oxazepam, 62 outpatients suffering from anxiety with depressive symptoms were evaluated. The average daily doses of alprazolam and oxazepam were 1.48 mg and 44.4 mg, respectively. According to all rating scales applied, both alprazolam and oxazepam were effective in relieving anxiety associated with mild depression (p less than 0.01). Alprazolam proved somewhat more effective than oxazepam especially with regard to overall performance (p less than 0.05). Treatment-emergent adverse effects were few and mild for both compounds tested.
authors.affiliation: Department of Psychiatry, University of Helsinki, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Rimón
authors.forename: E R
authors.initials: ER
authors.lastname: Kultalahti
authors.forename: A
authors.initials: A
authors.lastname: Kalli
authors.forename: T
authors.initials: T
authors.lastname: Koskinen
authors.forename: U
authors.initials: U
authors.lastname: Lepola
authors.forename: M
authors.initials: M
authors.lastname: Naarala
authors.forename: E
authors.initials: E
authors.lastname: Tick
mesh_terms: D000328:Adult; D000525:Alprazolam / Q000009:adverse effects / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D003863:Depression / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D010076:Oxazepam / Q000009:adverse effects / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales
chemical_list: D010076:Oxazepam; D000525:Alprazolam