title: Corticobasal degeneration. A unique pattern of regional cortical oxygen hypometabolism and striatal fluorodopa uptake demonstrated by positron emission tomography.
abstract: Corticobasal degeneration presents with an asymmetric akinetic-rigid syndrome, apraxia and combinations of supranuclear gaze palsy, myoclonus, and an alien limb. Six patients aged 59-77 yrs, diagnosed on clinical criteria as having corticobasal degeneration, have been studied with positron emission tomography using tracers of dopamine storage capacity and oxygen metabolism. Striatal 18F-6-fluorodopa uptake was reduced in an asymmetric pattern, caudate and putamen being involved in all cases. Uptake into medial frontal cortex was also impaired. Regional cortical oxygen metabolism was most significantly depressed in the superior and posterior temporal, inferior parietal, and occipital associated cortices. Within the frontal lobe, the hypometabolism was chiefly posterior. This unique combination of regional hypometabolism and disruption of the nigrostriatal system is discussed in relation to the clinical features of the disease and is compared with reported findings in other disorders of cognition and movement.
authors.affiliation: MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
authors.forename: G V
authors.initials: GV
authors.lastname: Sawle
authors.forename: D J
authors.initials: DJ
authors.lastname: Brooks
authors.forename: C D
authors.initials: CD
authors.lastname: Marsden
authors.forename: R S
authors.initials: RS
authors.lastname: Frackowiak
mesh_terms: D000368:Aged; D000818:Animals; D001072:Apraxias / Q000378:metabolism / Q000503:physiopathology; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D005121:Extremities / Q000503:physiopathology; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000378:metabolism; D009207:Myoclonus / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D013494:Supranuclear Palsy, Progressive / Q000378:metabolism; D013577:Syndrome; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D004295:Dihydroxyphenylalanine; D010100:Oxygen