Polychlorinated biphenyl congeners in blood of Wisconsin sport fish consumers.
As part of a study to evaluate the effect of chemical contaminants on Wisconsin sport fish consumers, measurements were made of polychlorinated biphenyl (PCB) congeners in human blood sera. A high resolution gas chromatography procedure was employed, with 13 individual congeners used as standards. Analytical recoveries and precision were greater than 90% and replicates were always within +/- 30%. Total concentrations, obtained by summing quantified congeners, ranged from 0.6 to 27.1 micrograms/L. Conventional packed column PCB analysis, conducted on a subset of samples, gave higher total PCB results. On a congener specific basis, congeners 153 (245-245), 138 (234-245), 180 (2345-245) and 118 (245-34) were found most often. These congeners have been reported to be prominent in other matrices. Of the congeners found, 118, 138, and possibly 180 are potentially the most toxic (based on current toxicological information).
Sonzogni
W
W
Laboratory of Hygiene, University of Wisconsin, Madison 53706.
Maack
L
L
Gibson
T
T
Degenhardt
D
D
Anderson
H
H
Fiore
B
B
D000818:Animals; D002849:Chromatography, Gas; D005399:Fishes; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D011078:Polychlorinated Biphenyls / Q000097:blood*; D014922:Wisconsin
D011078:Polychlorinated Biphenyls