title: Remission of juvenile chronic myeloid leukemia following graft failure of an unrelated marrow transplant and autologous recovery of marrow function promoted by GM-CSF and IL-3.
abstract: The unusual course of a boy with juvenile chronic myeloid leukaemia is presented. After bone marrow transplantation (BMT) from an unrelated donor followed by graft failure and subsequent stimulation by rhu GM-CFC and II-3, this patient experienced complete recovery of autologous haematopoiesis. At 17 months post-BMT the patient was off any therapy with completely normal blood counts and no signs of disease.
authors.affiliation: Department of Pediatrics, University of Kiel, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Suttorp
authors.forename: N
authors.initials: N
authors.lastname: Schmitz
authors.forename: E
authors.initials: E
authors.lastname: Prange
authors.forename: W
authors.initials: W
authors.lastname: Oster
authors.forename: H
authors.initials: H
authors.lastname: Löffler
authors.forename: J
authors.initials: J
authors.lastname: Schaub
authors.forename: A
authors.initials: A
authors.lastname: Ganser
mesh_terms: D016026:Bone Marrow Transplantation; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006410:Hematopoiesis; D006801:Humans; D007223:Infant; D007377:Interleukin-3 / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery / Q000628:therapy*; D008297:Male; D011994:Recombinant Proteins
chemical_list: D007377:Interleukin-3; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor