Arteriographic findings in EDTA chelation therapy on peripheral arteriosclerosis.
In a randomized, double-blind, controlled study, 153 patients with claudication were each given either 20 infusions of Na2EDTA or 20 infusions of saline. Walking distances and ankle/brachial indices were measured before, during, and after treatment. In 30 patients, angiograms and transcutaneous oxygen tensions were obtained before, during, and after treatment. The patients' subjective evaluations of the effect of treatment were also recorded. It is concluded that EDTA chelation therapy has no effect in patients with intermittent claudication in the legs caused by arteriosclerosis.
Sloth-Nielsen
J
J
Department of Vascular Surgery, Skejby Hospital, Aarhus, Denmark.
Guldager
B
B
Mouritzen
C
C
Lund
E B
EB
Egeblad
M
M
Nørregaard
O
O
Jørgensen
S J
SJ
Jelnes
R
R
D000328:Adult; D015901:Angiography, Digital Subtraction; D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004492:Edetic Acid / Q000627:therapeutic use*; D005080:Exercise Test; D005500:Follow-Up Studies; D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy; D007866:Leg / Q000098:blood supply*; D010100:Oxygen / Q000032:analysis; D010991:Plethysmography; D013997:Time Factors
D004492:Edetic Acid; D010100:Oxygen