UV induction of LexA independent proteins which could be involved in SOS repair.
The SOS response is induced in E coli following treatments that interfere with DNA replication. The response is under the control of the recA and the lexA genes. Strains defective in LexA repressor constitutively express SOS proteins. However, SOS repair does not reach its maximum level in these strains. Instead, an activation of RecA protein and de novo protein synthesis are required for full repair. We have analyzed by 2-dimensional gel electrophoresis the induction of proteins after UV irradiation of lexA(Def) bacteria. Proteins which might participate in SOS repair are induced under these conditions.
Lesca
C
C
Laboratoire de Pharmacologie et de Toxicologie Fondamentales, CNRS 205, Toulouse, France.
Petit
C
C
Defais
M
M
D001426:Bacterial Proteins / Q000235:genetics / Q000528:radiation effects*; D004260:DNA Repair / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics / Q000528:radiation effects*; D012097:Repressor Proteins / Q000235:genetics / Q000528:radiation effects*; D013014:SOS Response, Genetics / Q000528:radiation effects; D012697:Serine Endopeptidases; D014466:Ultraviolet Rays; D000099160:LexA Repressor Protein
D001426:Bacterial Proteins; D012097:Repressor Proteins; D012697:Serine Endopeptidases; D000099160:LexA Repressor Protein