Conditioned place preference produced by infusion of Met-enkephalin into the medial preoptic area.
The conditioned place preference procedure was used to evaluate the rewarding properties of D-Ala2-Met5-enkephalinamide (DALA) after bilateral infusion into the medial preoptic area. Doses of 60, 250 and 100 ng/cannula were used. It was found that all doses of DALA produced place preference. This suggests that the medial preoptic area is a structure where opioid reward is produced in doses as low as those required in already established reward systems. The significance of this in relation to sexual reward is discussed.
Agmo
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Department of Psychology, Universidad Anáhuac, Mexico City, Mexico.
Gómez
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D000704:Analysis of Variance; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004744:Enkephalin, Methionine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007263:Infusions, Parenteral; D008297:Male; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology; D012201:Reward
D004744:Enkephalin, Methionine; C022118:enkephalinamide-Met, Ala(2)-