Correlation of aggregometry responses to changes in light transmission through platelet packs.
The transmission of light through 22 platelet packs was monitored during storage with a specially designed apparatus in order to estimate the quality of the platelet concentrates without risking contamination. The changes in light transmission during a 7 day storage period were compared with other properties of platelets upon day 1 and day 7, namely aggregometry responses (to collagen, ADP, and calcium ionophore A23187), platelet factor 4 release, lactate dehydrogenase extracellular activity and pH. On day 7 additional aggregometry tests were carried out with pairs of activators (collagen + ADP, collagen + A23187, collagen + epinephrine, and collagen + arachidonic acid). The 8 concentrates judged as being inferior in quality by the optical apparatus also, with 1 exception, showed inferior quality as assessed from aggregometry responses and/or biochemical analyses.
Järemo
P
P
Blood Transfusion Centre, Medical Center Hospital, Orebro, Sweden.
Sollen
C
C
Edlund
B
B
Berseus
O
O
D001792:Blood Platelets / Q000502:physiology*; D001800:Blood Specimen Collection; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008027:Light; D008722:Methods; D008838:Microcomputers; D010974:Platelet Aggregation