[The interaction of Legionella pneumophila with different types of cell cultures and the effect of interferon preparations on this process].
The interaction of L. pneumophila with lymphoblastoid cell cultures H9 and H9/IIIB and epithelial cell cultures HEp-2 mutual influence have been noted. L. pneumophila penetrates into cells HEp-2 and multiplies there due the so-called "spin phagocytosis". The study of the influence of the preparations of interferon, Leukinferon and Reaferon, on the adhesive capacity of bacteria and their penetration into eukaryotic cells has revealed that the preliminary treatment of both bacteria and cells HEp-2 with the preparations of interferon prior to their infection with Legionella leads to a decrease in the number of microorganisms associated with cells.
Nebozhina
L V
LV
Klitsunova
N V
NV
Tartakovskiĭ
I S
IS
Bykovskiĭ
A N
AN
D001422:Bacterial Adhesion / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects / Q000382:microbiology / Q000648:ultrastructure; D016207:Cytokines / Q000494:pharmacology*; D004338:Drug Combinations; D005455:Fluorescent Antibody Technique; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007875:Legionella / Q000187:drug effects / Q000472:pathogenicity* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011994:Recombinant Proteins
D016207:Cytokines; D004338:Drug Combinations; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; C062252:leukinferon
Vzaimodeĭstvie Legionella pneumophila s razlichnymi tipami kletochnykhkul'tur i vliianie na étot protsess preparatov interferona.