Human renin in transgenic mouse kidney is localized to juxtaglomerular cells.
To examine whether expression of human renin in the transgenic mouse kidney is regulated in a cell-specific manner, we have characterized monoclonal antibodies against human renin and determined the renin-production site by immunohistochemistry. By using a monoclonal antibody specific for human renin, A6-11-6, we demonstrated that human renin in the transgenic mouse kidney is localized to the juxtaglomerular cells of afferent arterioles.
Fukamizu
A
A
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
Hatae
T
T
Kon
Y
Y
Sugimura
M
M
Hasegawa
T
T
Yokoyama
M
M
Nomura
T
T
Katsuki
M
M
Murakami
K
K
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007606:Juxtaglomerular Apparatus / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D051379:Mice; D008822:Mice, Transgenic; D012083:Renin / Q000378:metabolism*; D000092502:Renin Inhibitors
D000911:Antibodies, Monoclonal; D012083:Renin; D000092502:Renin Inhibitors