Chromosomal mapping of brain-derived neurotrophic factor and neurotrophin-3 genes in man and mouse.
Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NTF3) are two new members of the nerve growth factor gene family, which play important roles in the development and maintenance of the vertebrate nervous system. Here we describe the assignments of the BDNF and NTF3 gene loci to human and mouse chromosomes and discuss the evolutionary relationship of human chromosomes 11 and 12. BDNF has been mapped to human chromosome 11p15.5-p11.2 and to mouse chromosome 2, and NTF3 to human chromosome 12p and mouse chromosome 6.
Ozçelik
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Howard Hughes Medical Institute, Stanford University Medical Center, California 94305.
Rosenthal
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Francke
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D000818:Animals; D019208:Brain-Derived Neurotrophic Factor; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D006224:Cricetinae; D003412:Cricetulus; D005819:Genetic Markers; D006728:Hormones / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D051379:Mice / Q000235:genetics*; D005810:Multigene Family; D009414:Nerve Growth Factors / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020933:Neurotrophin 3; D009857:Oncogenes; D010802:Phylogeny; D051381:Rats; D013045:Species Specificity
D019208:Brain-Derived Neurotrophic Factor; D005819:Genetic Markers; D006728:Hormones; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D020933:Neurotrophin 3