title: A model for asymmetric septum formation during sporulation in Bacillus subtilis.
abstract: Many differentiation processes in both prokaryotes and eukaryotes begin with an asymmetric division, producing 'daughter' cells that differ in size and developmental fate. This is particularly obvious in the well-studied prokaryotic life cycles of Caulobacter and Bacillus. In no system, however, is the mechanism of asymmetric division understood. Here I propose a model for the mechanism of asymmetric division during sporulation in Bacillus subtilis. The model explains both the timing and asymmetric localization of spore-septum formation. It also explains the morphological phenotypes of various asporogenous (spo) mutants.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, UK.
authors.forename: J
authors.initials: J
authors.lastname: Errington
mesh_terms: D001412:Bacillus subtilis / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D002473:Cell Wall / Q000502:physiology; D004261:DNA Replication / Q000502:physiology; D008954:Models, Biological; D013171:Spores, Bacterial / Q000502:physiology