[Comparative evaluation of the protective effect of sodium valproate, phenazepam and ionol in stress-induced liver damage in rats].
Ionol, a synthetic antioxidant, limits the stressor liver injury to a greater extent than sodium, valproate and phenazepam, activators of a GABA-ergic link of the stress-limiting organism systems. This injury is exhibited in the organospecific elevated levels of blood enzymes fructosediphosphate aldolase depression of N-demethylase activity of microsomal monooxygenases and a decrease in the amount of cytochromes P-450 and B5.
Nikonorov
A A
AA
Tverdokhlib
V P
VP
D000818:Animals; D014151:Anti-Anxiety Agents; D000975:Antioxidants / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000172:deficiency; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors* / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism*; D014635:Valproic Acid / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D000975:Antioxidants; D001570:Benzodiazepinones; D001569:Benzodiazepines; D002084:Butylated Hydroxytoluene; C017928:phenazepam; D014635:Valproic Acid; D003577:Cytochrome P-450 Enzyme System; D005634:Fructose-Bisphosphate Aldolase
Sravnitel'naia otsenka zashchitnogo éffekta val'proata natriia, fenazepama i ionola pri stressovom povrezhdenii pecheni u krys.