title: The value of menotrophin treatment for unexplained infertility prior to an in-vitro fertilization attempt.
abstract: This work was undertaken in order to evaluate retrospectively the relative efficacy of ovulation induction by menotrophins and that of in-vitro fertilization and embryo transfer (IVF-ET) in the treatment of unexplained infertility. These two treatments were compared between two groups of patients: 87 couples undergoing 446 cycles of ovulation induction by menotrophins (group A) and 72 couples undergoing 108 cycles of IVF-ET (group B). A total of 30 and 20 pregnancies were achieved in groups A and B for a rate of 34 and 28% per patient, respectively. A similar cumulative pregnancy rate (CPR) was achieved for three cycles of ovulation induction (23%) and one cycle of IVF-ET (22%). The cumulative live birth rate (CLBR) in group A was 22% after three cycles and exceeded that of one IVF-ET cycle (17%). It is concluded that menotrophin treatment in unexplained infertility is highly beneficial and should precede an IVF attempt.
authors.affiliation: Department of Obstetrics and Gynaecology, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.forename: B
authors.initials: B
authors.lastname: Avidan
authors.forename: N
authors.initials: N
authors.lastname: Mordel
authors.forename: A
authors.initials: A
authors.lastname: Lewin
authors.forename: A
authors.initials: A
authors.lastname: Samueloff
authors.forename: G
authors.initials: G
authors.lastname: Zajicek
authors.forename: J G
authors.initials: JG
authors.lastname: Schenker
authors.forename: N
authors.initials: N
authors.lastname: Laufer
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D008596:Menotropins / Q000627:therapeutic use*; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D008596:Menotropins