[The effect of microsomal enzyme inducers on the renal transport of verografin (triombrast)].
In experiments on rats and dogs it was shown that administration of phenobarbital (20 and 50 mg/kg orally, 4 days), benzonal (35 mg/kg, orally, 4 days), zixorine (200 mg/kg orally, 4 days) and 3-methylcholanthrene (20 mg/kg subcutaneously, 2 days) caused on the 3rd day following the last administration of the drug a reduction of verografine secretion in the kidneys. After administration of phenobarbital to dogs (20 mg/kg orally, 4 days) a decrease of renal transport of verografine within 4-5 weeks was observed.
Ul'ianov
G P
GP
Lampatov
V V
VV
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003974:Diatrizoate Meglumine / Q000032:analysis / Q000493:pharmacokinetics*; D004285:Dogs; D004790:Enzyme Induction / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008861:Microsomes / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013997:Time Factors
D003974:Diatrizoate Meglumine
Vliianie induktorov mikrosomal'nykh fermentov na pochechnyĭ transport verografina (triombrasta).