Hematopoietic stem cells in +/+, nu/+, and nu/nu C57Bl/10 mice.
Mice with the nu mutation have been shown to have a reduced incidence of spleen colony-forming units (CFU-S), with a higher variability between individual mice compared to +/+ mice. The presence of these defects also in nu/+ mice indicates that this mutation is a codominant trait and that the hematopoietic changes may not be solely caused by thymus dysgenesis. The proportion of CFU-S synthesizing DNA (approximately 40%) has not been significantly different between +/+, nu/+, and nu/nu mice.
Necas
E
E
Department of Pathophysiology, First Faculty of Medicine, Charles University, Prague, Czechoslovakia.
Znojil
V
V
Holub
M
M
D000818:Animals; D001835:Body Weight; D001854:Bone Marrow Cells; D004247:DNA / Q000096:biosynthesis; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D006579:Heterozygote; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D009154:Mutation; D013154:Spleen / Q000166:cytology
D004247:DNA