The effect of topical nitroglycerin on transcutaneous oxygen.
The use of topical nitroglycerin has been reported to aid the healing of chronic skin ulcers. In this study, the effect of 2% nitroglycerin ointment on transcutaneous oxygen pressure (TcPO2) was investigated in skin adjacent to the area of ointment application. Topical nitroglycerin caused a two-fivefold decrease in TcPO2 in skin next to or up to 9 cm away from the site of application of the ointment.
Romanelli
M
M
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL 33101.
Katz
M H
MH
Alvarez
A F
AF
Eaglstein
W H
WH
Falanga
V
V
D000287:Administration, Topical; D000328:Adult; D001785:Blood Gas Monitoring, Transcutaneous; D005260:Female; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D010100:Oxygen / Q000378:metabolism*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012883:Skin Ulcer / Q000188:drug therapy
D005996:Nitroglycerin; D010100:Oxygen