Particle track structure and its correlation with radiobiological endpoint.
One of the possible ways to classify track structures is application of the conventional partition techniques of analysis of multidimensional data to the track structure. Using these cluster algorithms this paper attempts to find characteristics of radiation reflecting the spatial distribution of ionizations in the primary particle track. Absolute frequency distributions of clusters giving the mean number of clusters produced by radiation per unit of deposited energy have been computed for radiation of different qualities. The results were compared with the published experimental data of cell inactivation. For particular biological objects the critical properties of radiation correlating with the cell inactivation can be found and it seems that the occurrence of a cluster of at least four ionizations formed in a domain of approximately 2-3 nm correlates with the induction of double strand break.
Michalik
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Division of Biophysics, Joint Institute for Nuclear Research, Dubna, Moscow, USSR.
D007477:Ions; D009010:Monte Carlo Method; D010315:Particle Accelerators; D012062:Relative Biological Effectiveness
D007477:Ions