title: Control of ColE1 plasmid replication by antisense RNA.
abstract: One of the two major classes of regulatory strategies that control plasmid copy number involves recognition via base pairing between two plasmid-encoded complementary RNAs. The detailed analysis of this control circuitry has revealed some features of regulatory mechanisms based on RNA-RNA interaction that distinguish them from those based on protein-nucleic acid interaction. These features provide a framework with which to understand other regulatory mechanisms based on RNA-RNA interaction, and will aid in the design of efficient artificial antisense RNA systems.
authors.affiliation: Department of Biology, II University of Rome Tor Vergata, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cesareni
authors.forename: M
authors.initials: M
authors.lastname: Helmer-Citterich
authors.forename: L
authors.initials: L
authors.lastname: Castagnoli
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D003086:Bacteriocin Plasmids / Q000235:genetics*; D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis; D005784:Gene Amplification; D016372:RNA, Antisense / Q000502:physiology*; D016601:RNA-Binding Proteins
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D016372:RNA, Antisense; D016601:RNA-Binding Proteins; C054243:Rop protein, ColE1 plasmid