[Study of the effect of an inhibitor of carnitine-dependent metabolism of mildronate on the oxidation of fatty acids in the liver mitochondria of intact rats].
Effect af antiischemic drug mildronate 3-(2,2,2-trimethylhydrazinium) propionate on oxidation of sodium octanoate and L-palmitoyl carnitine was studied in liver mitochondria of intact rats using polarographic procedure. After 10 days of administration of mildronate at a dose of 200 mg/kg per os oxidation of sodium octanoate was stimulated in liver mitochondria while the rate of L-palmitoyl carnitine oxidation was unaltered. The data obtained suggest that mildronate stimulated the carnitine-independent fatty acid oxidation which appears to occur as a compensation for inhibition of the carnitine-dependent oxidation by the drug.
Kagan
T I
TI
Simkhovich
B Z
BZ
Kalvinysh
I Ia
IIa
Lukevits
E Ia
EIa
D000818:Animals; D002331:Carnitine / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats
D005227:Fatty Acids; D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate; D002331:Carnitine
Izuchenie vliianiia ingibitora karnitinzavisimogo metabolizma mildronata na okislenie zhirnykh kislot mitokhondrii pecheni intaktnykh krys.