Co-production of interleukin-1 and interleukin-6 in tumor cell lines elaborating colony-stimulating factors.
Six carcinoma cell lines elaborating colony-stimulating factors (CSFs) were examined by enzyme-linked immunosorbent assay and Northern blotting to determine whether or not they co-produced interleukin-1 alpha (IL-1 alpha), IL-1 beta and IL-6. All 6 cell lines were co-producers; IL-1 alpha was produced in all 6, IL-6 in 5 and IL-1 beta in 3 of them. These results indicate that IL-1 and IL-6 are commonly co-produced in CSF-producing tumors.
Okuno
Y
Y
Second Department of Internal Medicine, Faculty of Medicine, Kyoto University.
Takahashi
T
T
Suzuki
A
A
Fukumoto
M
M
Nakamura
K
K
Imura
H
H
D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured / Q000378:metabolism*
D003115:Colony-Stimulating Factors; D007375:Interleukin-1; D015850:Interleukin-6