[The sensitizing properties of the ballast admixtures in human leukocyte interferon].
Due to the features of its production technology, human leukocyte interferon (HLI) for intranasal administration is likely to contain ovalbumin (OA). Commercial batches of HLI were tested for the presence of OA responsible for the sensitizing effect of HLI given intranasally. The content of OA in commercial batches of HLI was shown to vary widely and to exceed by far the concentrations having the sensitizing effect. As a result of these studies, the upper limit of OA content was established and the technology of HLI production was modified. These measures permitted production of commercial batches of HLI with OA content not exceeding 0.05 micrograms/ml.
Nikolaeva
E I
EI
Vardanian
N V
NV
Bektimirov
T A
TA
Popov
V F
VF
D000707:Anaphylaxis / Q000139:chemically induced / Q000276:immunology; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004340:Drug Contamination; D006168:Guinea Pigs; D006801:Humans; D007370:Interferon Type I / Q000032:analysis / Q000276:immunology* / Q000592:standards; D010047:Ovalbumin / Q000032:analysis / Q000276:immunology
D007370:Interferon Type I; D010047:Ovalbumin
Izuchenie sensibiliziruiushchikh svoĭstv ballastnykh primeseĭ chelovecheskogo leĭkotsitarnogo interferona.