title: In situ oncocytic change in association with multiple renal cell adenocarcinomas.
abstract: We report a case of in situ oncocytic change in association with two low-grade renal cell adenocarcinomas and one contralateral low-grade oncocytic adenocarcinoma. The in situ oncocytic change showed abundant cytoplasmic mitochondria confirmed by ultrastructural examination and phosphotungstic acid-hemotoxylin staining. In addition, this in situ oncocytic change expressed cytokeratin CAM 5.2 in the absence of cytokeratin AE1/AE3, as reported in oncocytic renal cell adenocarcinomas. Further study of in situ oncocytic change identified in kidneys resected for adenocarcinomas with regard to follow-up and management of the contralateral kidney seems indicated.
authors.affiliation: Department of Pathology, Emory University School of Medicine, Atlanta, GA.
authors.forename: E
authors.initials: E
authors.lastname: Lense
authors.forename: R
authors.initials: R
authors.lastname: Siegel
authors.forename: K
authors.initials: K
authors.lastname: Hewan-Lowe
authors.forename: M J
authors.initials: MJ
authors.lastname: Costa
mesh_terms: D002277:Carcinoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D014057:Tomography, X-Ray Computed