[Use of mass spectrometry with chemical ionization in screening antibacterial antibiotics with a broad spectrum of action (aminoglycosides and macrolides)].
It is shown that mass-spectrometry with ammonia desorption chemical ionization (ADCI) can be used for identification of aminoglycosides and macrolides at the initial stages of screening. ADCI can also be used for selection of strains which form the lowest amounts of by-products, as well as for optimization of biosynthetic conditions.
Rozynov
B V
BV
Zhdanovich
Iu V
IuV
Nasonova
L I
LI
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D007477:Ions; D018942:Macrolides; D013058:Mass Spectrometry / Q000379:methods*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D007477:Ions; D018942:Macrolides
Primenenie mass-spektrometrii s khimicheskoĭ ionizatsieĭ pri skrininge antibakterial'nykh antibiotikov s shirokim spektrom deĭstviia (aminoglikozidy i makrolidy).