Catecholamine uptake, melanization, and oxygen toxicity in Cryptococcus neoformans.
Oxygen sensitivity mutations of Cryptococcus neoformans were mapped to three genetic loci. Three oxygen-sensitive mutants had mutations that appeared allelic and exhibited albinism tightly linked to oxygen sensitivity; these three and a fourth exhibited defects in catechol uptake and catechol oxidation to melanin. Catecholamine metabolism appears to protect C. neoformans from oxidants.
Jacobson
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Research Service, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249.
Emery
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D001692:Biological Transport; D002395:Catecholamines / Q000378:metabolism*; D003433:Crosses, Genetic; D003455:Cryptococcus neoformans / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D005798:Genes, Bacterial; D008040:Genetic Linkage; D008543:Melanins / Q000096:biosynthesis*; D014442:Monophenol Monooxygenase / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D010100:Oxygen / Q000494:pharmacology*; D010641:Phenotype
D002395:Catecholamines; D008543:Melanins; D014442:Monophenol Monooxygenase; D010100:Oxygen