[In vitro activity of cefuroxime against Moraxella (Branhamella) catarrhalis].
Minimal inhibitory concentrations of cefuroxime were determined by an agar dilution procedure and compared with erythromycin and four other beta-lactam antibiotics (amoxycillin, amoxycillin + clavulanate, cefadroxil, cefaclor) on 76 strains of Moraxella (Branhamella) catarrhalis. Sixty four of them produced a beta-lactamase. Results show that the beta-lactamase of Moraxella (Branhamella) catarrhalis abrogates the activity of amoxycillin (MIC 90% = 4 mg/l) meanwhile the combination of amoxycillin-clavulanate is inhibitory at low concentration (MIC 90% = 0.25 mg/l). There are no difference in MICs between strains producing or not producing beta-lactamase with erythromycin (MIC 90% = 0.25 mg/l). All the strains evaluated in this investigation, producing or not producing beta-lactamase have MIC 90% less than or equal to 2 mg/l for cefuroxime lower than those obtained for the two other cephalosporins.
Laurans
G
G
Laboratoire de Bactériologie-Immunologie Générale, Centre Hospitalo-Universitaire d'Amiens.
Gaudio
F
F
Ducroix
J P
JP
Orfila
J
J
D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002433:Cefaclor / Q000494:pharmacology; D002434:Cefadroxil / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D066298:In Vitro Techniques; D001936:Moraxella catarrhalis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D019818:Clavulanic Acid; D002434:Cefadroxil; D004917:Erythromycin; D002433:Cefaclor; D000658:Amoxicillin; D002444:Cefuroxime
Evaluation in vitro de l'activité du céfuroxime sur Moraxella (Branhamella) catarrhalis.