Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog.
To investigate the possible hemodynamic effects of interleukin-6 (IL-6), a single dose of 15 mcg/kg of recombinant IL-6 isolated from Escherichia coli was injected intravenously in six pentobarbital-anesthetized dogs. After 30 min, saline infusion was performed to maintain the pulmonary artery balloon-occluded pressure at baseline level. The animals were observed for up to 5 hours. No other hemodynamic alteration was observed than a gradual decline in cardiac output attributed to anesthesia. Hematologic variables, blood glucose, and total serum proteins were also constant. IL-6 levels were markedly elevated in the blood, but no tumor necrosis factor activity was detected. Thus a primary role for IL-6 in the early cardiovascular alterations associated with septic shock seems unlikely.
Preiser
J C
JC
Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium.
Schmartz
D
D
Van der Linden
P
P
Content
J
J
Vanden Bussche
P
P
Buurman
W
W
Sebald
W
W
Dupont
E
E
Pinsky
M R
MR
Vincent
J L
JL
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects*; D006454:Hemoglobins / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D011994:Recombinant Proteins / Q000097:blood / Q000494:pharmacology; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D006454:Hemoglobins; D015850:Interleukin-6; D011994:Recombinant Proteins; D010100:Oxygen