title: HTLV-I neurotropism. In vitro studies.
abstract: The human T cell leukemia lymphoma virus (HTLV-I) has been recently associated to neurological disorders. In order to investigate the interaction between this virus and the central nervous system, cells of neuroectodermic origin have been exposed to HTLV-I through an experimental in vitro model. The results revealed the presence of HTLV-I virus core protein p19 inside glial cells, after a short time exposure to a chronically infected donor cell line. This suggests a possible role of a lymphotropic retrovirus in neurological diseases.
authors.affiliation: Department of Experimental Medicine and Biochemical Science, University of Rome, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Macchi
authors.forename: B
authors.initials: B
authors.lastname: Caronti
authors.forename: F
authors.initials: F
authors.lastname: Gremo
authors.forename: S
authors.initials: S
authors.lastname: Torelli
authors.forename: E
authors.initials: E
authors.lastname: Bonmassar
authors.forename: G M
authors.initials: GM
authors.lastname: Lauro
mesh_terms: D000818:Animals; D015490:HTLV-I Infections / Q000503:physiopathology*; D006801:Humans; D009422:Nervous System Diseases / Q000382:microbiology / Q000503:physiopathology*