title: [A retrospective study of ruptured abdominal aortic aneurysms--association with respiratory function and leukocytic granular elastase].
abstract: Fifty-two cases of abdominal aortic aneurysms including common iliac aneurysms operated on during July, 1981 and December, 1989 have been studied. They were divided into the following three of elective operation (n = 34), impending rupture (n = 5), and ruptured (n = 13) groups. Cases with abdominal operations without aneurysms were randomly selected as the control group (n = 12). Overall operative mortality was 9.6%, consisted of 30.8% of the ruptured, 20.0% of the impending rupture and 0% of the elective operation groups. Respiratory functions including FEV1.0%, V75, V50, V25 and V25/Ht were significantly lowered in the ruptured group. PaO2 of the ruptured group was also significantly lowered in comparison with both the control and the elective operation groups. Leukocytic granular elastase, playing a role of destruction of the elastin component in the pulmonary alveoli and the aortic media, was increased in the patients with ruptured aortic aneurysms, though the difference was not significant. The data suggested the possibility of aneurysm rupture in case with elevated leukocytic granular elastase. Surgery for abdominal aortic aneurysm, even in cases with decreased pulmonary function, should be considered aggressively to elimination of ominous result of aneurysm rupture.
authors.affiliation: Second Department of Surgery, Kagoshima University Faculty of Medicine, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Ishibe
authors.forename: M
authors.initials: M
authors.lastname: Maruko
authors.forename: K
authors.initials: K
authors.lastname: Arikawa
authors.forename: D
authors.initials: D
authors.lastname: Tabata
authors.forename: H
authors.initials: H
authors.lastname: Masuda
authors.forename: T
authors.initials: T
authors.lastname: Kinjo
authors.forename: A
authors.initials: A
authors.lastname: Taira
mesh_terms: D000368:Aged; D001012:Aorta, Abdominal; D001019:Aortic Rupture / Q000201:enzymology / Q000503:physiopathology / Q000601:surgery*; D001784:Blood Gas Analysis; D006801:Humans; D019272:Leukocyte Elastase; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood*; D012119:Respiration; D012129:Respiratory Function Tests; D012189:Retrospective Studies
chemical_list: D010196:Pancreatic Elastase; D019272:Leukocyte Elastase