title: Variation in induction of chromosomal beta-lactamase expression in strains of Enterobacter cloacae.
abstract: Eight strains of Enterobacter cloacae with varying patterns of susceptibility to beta-lactam antibiotics were studied to compare the inducibility and expression of their beta-lactamase genes. These strains included two isolates from one patient, which differed in their susceptibility to cefamandole. A resistant strain constitutively produced large amounts of beta-lactamase; a sensitive strain produced an inducible beta-lactamase. Study of induction and growth characteristics of all strains revealed that the induction and the expression of inducible beta-lactamase genes may vary considerably among strains of E. cloacae.
authors.affiliation: Department of Medical Microbiology, University Hospital, Leiden, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Stoorvogel
authors.forename: M H
authors.initials: MH
authors.lastname: van Gestel
authors.forename: P A
authors.initials: PA
authors.lastname: Ketelaar-van Gaalen
authors.forename: R P
authors.initials: RP
authors.lastname: Mouton
authors.forename: J A
authors.initials: JA
authors.lastname: van de Klundert
mesh_terms: D000328:Adult; D000818:Animals; D002876:Chromosomes, Bacterial / Q000201:enzymology*; D004754:Enterobacter / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D004790:Enzyme Induction; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D013045:Species Specificity; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000302:isolation & purification
chemical_list: D001618:beta-Lactamases