[Contraceptive activity of RU486 and oral active prostaglandin combination].
The most used medical method for early pregnancy interruption associates the antiprogestin RU486 (Mifepristone) and an intramuscularly injected prostaglandin (Sulprostone) (Silvestre et al., New Engl. J. Med., 322, 1990, pp. 645-648). Misoprostol, an orally active PGE1 synthetic derivative, showed the same efficacy as Sulprostone in a trial including 100 patients. The medical characteristics and potential of the new method are briefly discussed.
Aubeny
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Centre d'Orthogénie de l'Hôpital Broussais, Service du Pr P. Poitout, Paris.
Baulieu
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EE
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D000029:Abortion, Legal / Q000379:methods*; D000284:Administration, Oral; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage / Q000627:therapeutic use*; D016595:Misoprostol; D011247:Pregnancy
D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol; D015735:Mifepristone; D000527:Alprostadil
Activité contragestive de l'association au RU486 d'une prostaglandine active par voie orale.