The fate of trimethylamine in the rat.
The metabolism and excretion of [14C]-trimethylamine has been investigated in seven strains of rat. Over 75% of the administered radioactivity was excreted via the urine within the first day, with up to 9% in the faeces. At this dose level (15 mg/kg body wt) N-oxidation was the major metabolic pathway encountered (45% excreted dose) whilst demethylation was only of minor importance (3%). The remaining compound was excreted unchanged. No significant differences were observed between the strains studied.
al-Waiz
M
M
Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, Paddington, London, England.
Mitchell
S C
SC
D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D005243:Feces / Q000737:chemistry; D005260:Female; D013058:Mass Spectrometry; D008744:Methylamines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D008744:Methylamines; C023336:trimethylamine