title: Comparative performance of 14-crown-4 derivatives as lithium-selective electrodes.
abstract: A series of neutral ionophore-based lithium-selective liquid-membrane electrodes have been prepared and the electrode performance compared with similar electrodes based on the lithium ionophores ETH 1810-ortho-nitrophenyl octyl ether (oNPOE) and ETH 2137-bis(1-butylpentyl) adipate (BBPA). By using a diamide substituted 14-crown-4 macrocycle, selectivities for Li+ in the presence of Na+ of log kpotLi,Na = -3.25 and -2.92 were obtained for diisobutylamide-oNPOE and di-n-butylamide-oNPOE derivatives. The di-n-butylamide-oNPOE based electrode functioned satisfactorily in serum, exhibiting a fast response time (10-15 s), an acceptable lifetime of 50 d and minimal protein interference.
authors.affiliation: Department of Chemistry, University of Durham, UK.
authors.forename: R
authors.initials: R
authors.lastname: Kataky
authors.forename: P E
authors.initials: PE
authors.lastname: Nicholson
authors.forename: D
authors.initials: D
authors.lastname: Parker
authors.forename: A K
authors.initials: AK
authors.lastname: Covington
mesh_terms: D001322:Autoanalysis / Q000379:methods; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy; D004566:Electrodes; D004988:Ethers, Cyclic; D006801:Humans; D007476:Ionophores; D008094:Lithium / Q000097:blood* / Q000627:therapeutic use; D016651:Lithium Carbonate; D008567:Membranes, Artificial
chemical_list: D004988:Ethers, Cyclic; D007476:Ionophores; D008567:Membranes, Artificial; D016651:Lithium Carbonate; D008094:Lithium