Decrease in blood histamine in drug-treated parkinsonian patients.
Blood histamine and serum histaminase activity were determined in a group of patients with Parkinson disease (PD) and in a group of healthy controls. Untreated PD patients present significantly higher blood histamine than normal controls. Therapy with L-dopa + cardidopa results in a significant decrease in blood histamine. This decrease becomes more accentuated when anticholinergics are added to this therapy. No significant changes were detected in plasma histaminase. The authors suggest, as a hypothesis, that the CNS contributes to blood histamine concentration and that its rise is the result of increased neuronal destruction.
Coelho
M H
MH
Instituto de Química Fisiológica, Serviço de Neurologia, Faculdade de Medicina de Lisboa, Portugal.
Silva
I J
IJ
Azevedo
M S
MS
Manso
C F
CF
D000328:Adult; D000368:Aged; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D002230:Carbidopa / Q000627:therapeutic use; D005260:Female; D006632:Histamine / Q000097:blood*; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000627:therapeutic use; D010300:Parkinson Disease / Q000097:blood* / Q000188:drug therapy
D000978:Antiparkinson Agents; D010276:Parasympatholytics; D007980:Levodopa; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D002230:Carbidopa