Comparative effects of an elemental and a complex enteral feeding formulation on the absorption of phenytoin suspension.
The effect of an elemental formula (Vivonex TEN) and a lactose-free complex formula (Ensure) on the oral absorption of a single dose of phenytoin suspension was determined in 10 normal volunteers. Following an overnight fast, subjects were randomly administered 400 mg of phenytoin suspension alone, phenytoin plus Vivonex TEN (unflavored), and phenytoin plus Ensure. The enteral feedings were given every 4 hours throughout the first 24 hours. Serum phenytoin concentrations were obtained over the 72-hour period following drug administration. No statistical difference in area under the curve (AUC), time to peak phenytoin concentration, or peak phenytoin concentration was observed during the three treatment phases. These data suggest that the two enteral feeding formulations investigated do not interfere with nor enhance or accelerate phenytoin absorption as determined by a single-dose study.
Marvel
M E
ME
Department of Medicine, Mary Imogene Bassett Hospital, Cooperstown, New York 13326.
Bertino
J S
JS
D000042:Absorption; D000328:Adult; D004750:Enteral Nutrition; D005260:Female; D005526:Food, Formulated; D006801:Humans; D007700:Kinetics; D008297:Male; D010672:Phenytoin / Q000493:pharmacokinetics*
D010672:Phenytoin