title: [Effects of cyclosporin A on male reproduction in rats].
abstract: Effects of cyclosporin (Cs) on male reproduction in rats were examined. A dose-dependent decrease of the sperm counts in the cauda epididymis was observed 6 weeks after Cs was administered. A significant decrease of sperm motility was also observed in the each Cs-treated group in any observational period after Cs injection, which suggested an injury to epididymis by Cs. A slight damage of the seminiferous tubules was demonstrated 6 weeks after administration of 40 or 60 mg/kg of Cs. No change in serum levels of luteinizing hormone and testosterone was demonstrated throughout the experiment. But serum levels of follicle-stimulating hormone were significant high in any observational period except 6 weeks after Cs injection. It was concluded that Cs gave injuries to both spermatogonia and epididymal function in rat.
authors.affiliation: Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
authors.forename: M
authors.initials: M
authors.lastname: Iwasaki
authors.forename: H
authors.initials: H
authors.lastname: Fuse
authors.forename: T
authors.initials: T
authors.lastname: Kazama
authors.forename: T
authors.initials: T
authors.lastname: Katayama
mesh_terms: D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*; D013076:Sperm Count / Q000187:drug effects; D013093:Spermatogonia / Q000187:drug effects; D013737:Testis / Q000187:drug effects*
chemical_list: D003524:Cyclosporins