Central administration of Lys-D-Pro-Thr, an interleukin-1 beta 193-195 analogue, stimulates feeding in rats.
We determined the effect on feeding of Lys-D-Pro-Thr (LDPT), an interleukin-1 beta 193-195 analogue which antagonizes the analgesic effects of interleukin-1 beta. Intracerebroventricular administration of 2 micrograms/rat LDPT increased food consumption at the 0-1 h time period, although food intake was reduced by LDPT at the 1-2 h time period. There was no effect on colonic temperature 1 h later. Subcutaneously injected LDPT (2 micrograms/rat) failed to increase food intake for 1 h. These data suggest that brain interleukin-1 beta may have a physiological role in feeding suppression.
Uehara
Y
Y
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Shimizu
H
H
Shimomura
Y
Y
Negishi
M
M
Fukatsu
A
A
Kashima
K
K
Tanaka
Y
Y
Kobayashi
I
I
D000595:Amino Acid Sequence; D000818:Animals; D002404:Catheterization; D004435:Eating / Q000187:drug effects*; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000494:pharmacology*; D053583:Interleukin-1beta; D008297:Male; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D007375:Interleukin-1; D053583:Interleukin-1beta; D010446:Peptide Fragments; C056932:interleukin 1beta (193-195)