[The thrombolytic activity of acylated activator complexes of plasmin-streptokinase with different rates of reactivation].
In the experiments on guinea-pigs with venous thrombosis there were studied the fibrin- and thrombolytic effects of streptokinase, the plasmin-streptokinase complex and the acylated derivatives of the complex with various rates of reactivation. It was established that the acylated derivatives of the plasmin-streptokinase complex possess greater stability in the blood flow and lead to more prolonged stimulation of fibrinolysis at less magnitude of its systemic activation. Due to this the acylated derivatives of the plasmin-streptokinase complex produce less pronounced fibrinogenolysis. In connection with a high affinity to fibrin their thrombolytic action does not depend on the systemic activation of fibrinolysis.
Bashkov
G V
GV
Aĭsina
R B
RB
Kazanskaia
N F
NF
Makarov
V A
VA
Sirotenko
A V
AV
Popova
G Iu
GIu
Zhitkova
Iu V
IuV
D000818:Animals; D016255:Anistreplase / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D005342:Fibrinolysis / Q000187:drug effects*; D006168:Guinea Pigs; D010960:Plasminogen Activators / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D013300:Streptokinase / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology
C018663:SK potentiator; D016255:Anistreplase; D013300:Streptokinase; D010960:Plasminogen Activators
Tromboliticheskaia aktivnost' atsilirovannykh aktivatornykh kompleksov plazmin--streptokinaza s razlichnymi skorostiami reaktivatsii.