Effect of the novel triazinium zwitterion 1-methyl-3-phenyl-1,2,4-triazinium-5-olate on immunological responses and experimental brucellosis in mice.
The immunopharmacology of a novel triazinium zwitterion, designated JR-6, was studied in mice. Experiments show dose-response inhibition of antibody and delayed-type hypersensitivity (DTH) responses to sheep red blood cell antigens. Suppression of DTH was confirmed using trinitrochlorobenzene as a contact-sensitizing antigen. Using a model of experimental brucellosis in mice, it was found that JR-6 caused suppression of specific antibody and DTH reaction, as well as spleen weight, but a statistically significant increase in viable counts of Brucella abortus was not observed. Extensive short-term toxicology studies showed reduction in lymphocyte and neutrophil counts, and slow weight gain of treated mice. However, organ histology, liver function tests and biochemical profiles were normal.
Zeng
T S
TS
Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Australia.
Halliday
W J
WJ
Jacobsen
N W
NW
Seow
W K
WK
Thong
Y H
YH
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002003:Brucella abortus / Q000276:immunology; D002006:Brucellosis / Q000276:immunology; D006968:Hypersensitivity, Delayed; D007107:Immune System / Q000187:drug effects*; D007166:Immunosuppressive Agents; D007962:Leukocytes / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D014227:Triazines / Q000494:pharmacology* / Q000633:toxicity; D015430:Weight Gain / Q000187:drug effects
D007166:Immunosuppressive Agents; D014227:Triazines; C057604:1-methyl-3-phenyl-1,2,4-triazin-5-one