title: Origins of replication: timing and chromosomal position.
abstract: Several new methods have been used to localize replication initiation sites in mammalian chromosomes. The results of these studies argue strongly for the presence of defined sequence elements that function much like the origins in the genomes of simple microorganisms. However, relatively disparate results from in vivo and in vitro studies suggest that initiation reactions in mammalian chromosomes may have unique features, possibly related to a more complicated chromosomal architecture.
authors.affiliation: Department of Biochemistry, University of Virginia School of Medicine, Charlottesville 22908.
authors.forename: J L
authors.initials: JL
authors.lastname: Hamlin
authors.forename: J P
authors.initials: JP
authors.lastname: Vaughn
authors.forename: P A
authors.initials: PA
authors.lastname: Dijkwel
authors.forename: T H
authors.initials: TH
authors.lastname: Leu
authors.forename: C
authors.initials: C
authors.lastname: Ma
mesh_terms: D000818:Animals; D002455:Cell Division / Q000235:genetics*; D002467:Cell Nucleus / Q000502:physiology* / Q000648:ultrastructure; D002875:Chromosomes / Q000502:physiology* / Q000648:ultrastructure; D004261:DNA Replication; D015870:Gene Expression; D005796:Genes; D007700:Kinetics; D008322:Mammals; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D013762:Tetrahydrofolate Dehydrogenase