[Use of dibunol in pharmacological correction of post-vagotomy hypoxia of digestive organs in rats].
1, 7, 14, 30 and 60 days after bilateral sub-diaphragmatic truncal vagotomy tension of oxygen (pO2) in liver, stomach and small intestine (jejunum) was determined. It was demonstrated that vagotomy leads to a decrease of pO2 in all investigated organs 1 day after the operation (such changes were observed in sham-operated rats) and 30 days, in jejunum--after 7 days, in liver--after 14 days, in stomach--after 60 days. Dibunol introduction in vagotomized rats during 29 days (starting from the second day after operation) results in pO2 normalization in all investigated organs.
Tsibulevskiĭ
A Iu
AIu
Polivoda
M D
MD
Ettinger
A P
AP
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D004064:Digestive System / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D007583:Jejunum / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010101:Oxygen Consumption; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution; D015167:Vagotomy, Truncal
D002084:Butylated Hydroxytoluene
Primenenie dibunola dlia farmakokorrektsii postvagotomicheskoĭ gipoksii pishchevaritel'nykh organov u krys.