Characterization of the mononuclear cell infiltrate and HLA-Dr expression in 19 oligodendrogliomas.
We have studied frozen tissue from 19 oligodendrogliomas with a panel of antibodies to lymphocytes and their subsets, macrophages, natural killer cells, and HLA-Dr antigens. Macrophages were detected in moderate numbers in 60%-100% of tumors depending on the antibody used. T lymphocytes were fewer in number than macrophages and were present in 62% of cases. Most of the T lymphocytes were of the CD8 phenotype. CD4 lymphocytes were very few in number and present in only 18%. B cells and natural killer cells were absent from all cases. HLA-Dr antigens were expressed by macrophages in all cases but never on tumor cells. The implications of these findings are that macrophages and, to a lesser extent, CD8 lymphocytes are the predominant cells infiltrating oligodendrogliomas and that they may exert cellular immune functions.
Rossi
M L
ML
Department of Neuropathology, Midland Centre for Neurology & Neurosurgery, Birmingham, Radcliffe Infirmary, Oxford, United Kingdom.
Esiri
M M
MM
Jones
N R
NR
Coakham
H B
HB
Moss
T H
TH
Cruz-Sanchez
F F
FF
Carey
M P
MP
D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007694:Killer Cells, Natural; D007963:Leukocytes, Mononuclear; D008264:Macrophages; D009837:Oligodendroglioma / Q000276:immunology* / Q000473:pathology; D016176:T-Lymphocyte Subsets
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens