title: [A multifactorial analysis of the combined action of an antibiotic and a low-molecular immunomodulator of microbial origin in experimental plague infection].
abstract: The combined effect of doxycycline and a low molecular weight immunomodulator of microbial origin was studied in experimental plague infection with mathematical design of the experiment. Synergism of the action of the antibiotic and immunomodulator used in subtherapeutic doses was observed. The action was the most pronounced when the drugs were applied therapeutically. On the basis of the multifactorial analysis the regimens for the use of the antibiotic and immunomodulator were optimized.
authors.forename: A V
authors.initials: AV
authors.lastname: Nikitin
authors.forename: L N
authors.initials: LN
authors.lastname: Makarovskaia
authors.forename: I P
authors.initials: IP
authors.lastname: Fomina
authors.forename: L P
authors.initials: LP
authors.lastname: Ivanitskaia
authors.forename: G O
authors.initials: GO
authors.lastname: Popova
authors.forename: N N
authors.initials: NN
authors.lastname: Vinidchenko
authors.forename: Ia N
authors.initials: IaN
authors.lastname: Korganov
authors.forename: M K
authors.initials: MK
authors.lastname: Kudinova
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005163:Factor Analysis, Statistical; D051379:Mice; D008970:Molecular Weight; D010930:Plague / Q000188:drug therapy* / Q000453:epidemiology / Q000401:mortality; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D004318:Doxycycline
vernacular_title: Mnogofaktornyĭ analiz sochetannogo deĭstviia antibiotika i nizkomolekuliarnogo immunomoduliatora mikrobnogo proiskhozhdeniia pri éksperimental'noĭ chumnoĭ infektsii.