Transient expression of c-fos during the development of the rat cerebral cortex.
The present study has explored with immunocytochemical methods the expression of the proto-oncogene c-fos during the pre- and postnatal development of the cerebral cortex of the rat. The immunostaining of the Fos protein follows a strikingly precise spatiotemporal pattern: it occurs uniquely within layer VIb of the developing cerebral cortex, and is transient, lasting only from embryonic day 20 until postnatal day 1. The expression of c-fos in layer VIb may be related to the dynamic changes that occur at this level during development.
González-Martín
C
C
Instituto Cajal, CSIC, Madrid, Spain.
de Diego
I
I
Fairén
A
A
Mellström
B
B
Naranjo
J R
JR
D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D015870:Gene Expression; D011518:Proto-Oncogene Proteins / Q000032:analysis / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos; D051381:Rats; D011919:Rats, Inbred Strains
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos