title: [The effect of cyclosporin A and oligomycin on the nonspecific permeability of the mitochondria inner membrane].
abstract: The effect of oligomycin and cyclosporine A on Ca(2+)-induced nonspecific permeability of the inner mitochondrial membrane was under study. Both oligomycin and cyclosporine A were able to prevent the activation of nonspecific permeability; however, but cyclosporine A was the only agent which could restore the initial permeability of the inner mitochondrial membrane. The effect of cyclosporine A was not shown to be mediated through redistribution of Ca2+ ions between different subpopulations of mitochondria.
authors.forename: S A
authors.initials: SA
authors.lastname: Novgorodov
authors.forename: T I
authors.initials: TI
authors.lastname: Gudz'
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Kushnareva
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Kudriashov
mesh_terms: D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism; D003524:Cyclosporins / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects / Q000502:physiology; D008930:Mitochondria, Liver / Q000187:drug effects*; D009840:Oligomycins / Q000494:pharmacology*; D010539:Permeability / Q000187:drug effects; D051381:Rats
chemical_list: D003524:Cyclosporins; D009840:Oligomycins; D002118:Calcium
vernacular_title: Deĭstvie tsiklosporina A i oligomitsina na nespetsificheskuiu pronitsaemost' vnutrenneĭ membrany mitokhondriĭ.