title: Nasopharyngeal flora in the first three years of life in normal and otitis-prone children.
abstract: Nasopharyngeal carriage of the three major middle ear pathogens (Streptococcus pneumoniae, nontypeable Hemophilus influenzae, and Moraxella catarrhalis) was evaluated prospectively in a group of 110 children followed up for the first 3 years of life. The findings suggested that nasopharyngeal carriage of middle ear pathogens increases significantly during respiratory illness among the general population of young children; however, otitis-prone children demonstrated a tendency to carry nontypeable H influenzae at an unusually high rate even during health. This propensity to carry nontypeable H influenzae might explain why nontypeable H influenzae is a major cause of recurrent or chronic otitis media.
authors.affiliation: Division of Infectious Diseases, State University of New York School of Medicine, Buffalo.
authors.forename: H
authors.initials: H
authors.lastname: Faden
authors.forename: M J
authors.initials: MJ
authors.lastname: Waz
authors.forename: J M
authors.initials: JM
authors.lastname: Bernstein
authors.forename: L
authors.initials: L
authors.lastname: Brodsky
authors.forename: J
authors.initials: J
authors.lastname: Stanievich
authors.forename: P L
authors.initials: PL
authors.lastname: Ogra
mesh_terms: D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D001936:Moraxella catarrhalis / Q000302:isolation & purification; D009305:Nasopharynx / Q000382:microbiology*; D010033:Otitis Media / Q000382:microbiology*; D011446:Prospective Studies; D012016:Reference Values; D012141:Respiratory Tract Infections / Q000382:microbiology; D012307:Risk Factors; D013296:Streptococcus pneumoniae / Q000302:isolation & purification