[Interleukin-2 and adoptive immunotherapy: their biological aspects and clinical application in oncology].
Interleukin-2 (IL2), as a modifier of the biological response, has been intravenously used in patients with advanced cancer associated or not to LAK cells or tumor infiltrating lymphocytes. In different neoplasias positive results have been obtained, being effective in melanoma and renal cancer. There are still, at present, many questions to be answered and multiple research lines are currently open. The association with other cytokines and new chemotherapy protocols grant new therapeutic possibilities.
Barón Saura
J M
JM
Servicio de Oncología Médica, Hospital La Paz, Madrid.
Pizarro Redondo
A
A
Berrocal Jaime
A
A
González Barón
M
M
D006801:Humans; D016219:Immunotherapy, Adoptive / Q000009:adverse effects; D007376:Interleukin-2 / Q000627:therapeutic use* / Q000633:toxicity; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*
D007376:Interleukin-2
Interleucina-2 e inmunoterapia adoptiva: aspectos biológicos y aplicación clínica en Oncología.