Dynamic model of 99mTc-labelled lipoprotein accumulation in rabbit liver.
To create a mathematical model to describe the receptor-mediated accumulation of 99mTc-labelled lipoproteins in rabbit liver, a set of differential equations was devised for the simplest case: that involving one ligand and one receptor. Normal and hypercholesterolemic rabbits were included in gammascintigraphic trials as having normal and reduced numbers, respectively, of liver low-density lipoprotein (LDL) receptors. The system described may have clinical applications as a quick and effective method of assessment of LDL uptake by the liver.
Anisimova OYu
Institute of Experimental Cardiology, Academy of Medical Sciences of the USSR, Moscow.
Volynskaya
E A
EA
Kuzmina
T I
TI
Danilevich
A B
AB
D000818:Animals; D005720:Gamma Rays; D008074:Lipoproteins / Q000378:metabolism*; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D008962:Models, Theoretical; D011817:Rabbits; D011877:Radionuclide Imaging; D011973:Receptors, LDL / Q000378:metabolism; D013667:Technetium
D008074:Lipoproteins; D011973:Receptors, LDL; D013667:Technetium