title: The effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases.
abstract: Vasoactive drugs have a variety of effects upon splanchnic and hepatic haemodynamics which may alter tumour blood flow and potentiate the delivery of a chemotherapeutic drug to hepatic tumour. We have investigated the effects of vasopressin infusion on hepatic tumour blood flow in an experimental model of liver tumour. Hepatic tumour was induced by the intraportal inoculation of HSN sarcoma cells. Hepatic and splanchnic blood flow was determined using a dual reference microsphere technique before and after an intravenous infusion of vasopressin at a dose of 0.1 mU kg-1 min-1 for 10 min. There was a significant increase in systemic arterial blood pressure associated with a rise in portal venous inflow (P less than 0.01, Wilcoxen Signed rank Test) and a significant fall in hepatic arterial flow (P less than 0.05). The tumour: liver blood flow ratio was significantly increased by vasopressin infusion (P less than 0.02). Vasopressin infusion decreases hepatic arterial flow and increases tumour blood flow which may potentiate the delivery of a regionally delivered chemotherapeutic drug to hepatic tumour.
authors.affiliation: University Department of Surgery, Glasgow Royal Infirmary, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Hemingway
authors.forename: D
authors.initials: D
authors.lastname: Chang
authors.forename: T G
authors.initials: TG
authors.lastname: Cooke
authors.forename: S A
authors.initials: SA
authors.lastname: Jenkins
mesh_terms: D000818:Animals; D006439:Hemodynamics / Q000187:drug effects*; D006499:Hepatic Artery / Q000502:physiology; D008114:Liver Neoplasms, Experimental / Q000098:blood supply*; D009362:Neoplasm Metastasis; D051381:Rats; D012039:Regional Blood Flow; D014667:Vasopressins / Q000494:pharmacology*
chemical_list: D014667:Vasopressins