[Activation of the Ha-ras oncogene in tumors induced in mice by transplacental exposure to 7,12-dimethylbenz(a)anthracene].
A study of tumors induced in mice by transplacental exposure to 7,12-dimethylbenz(a)anthracene (DMBA) alone or in combination with postnatal tissue-specific promotion showed skin and liver tumor development to be associated with cellular Ha-ras oncogene activation in a large percentage of cases. As shown by Xba I RFLP, oncogene activation was caused by T for A substitution at the second position of codon 61. The said mutation was traced in DMBA-induced tumors of the liver alone but not in spontaneous hepatomas. The results of the study showed the role of oncogene activation in cancer development to be tissue-specific.
Loktionov
A S
AS
Hollstein
M
M
Martel
N
N
Galendo
D
D
Tomatis
L
L
Yamasaki
H
H
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens; D003062:Codon / Q000187:drug effects / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects* / Q000235:genetics; D011905:Genes, ras / Q000187:drug effects* / Q000235:genetics; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation / Q000187:drug effects / Q000235:genetics; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics*; D010920:Placenta; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012878:Skin Neoplasms / Q000139:chemically induced / Q000235:genetics
D002273:Carcinogens; D003062:Codon; D015127:9,10-Dimethyl-1,2-benzanthracene
Aktivatsiia onkogena Ha-ras v opukholiakh, indutsirovannykh u mysheĭ transplatsentarnym vozdeĭstviem 7,12-dimetilbenz(a)antratsena.