Gonadotropins and combined gonadotropin-releasing hormone agonist--gonadotropins protocols in a randomized prospective study.
A prospective study was designed to compare cycles stimulated by human menopausal gonadotropin (hMG) (group A) with cycles pretreated with gonadotropin-releasing hormone agonist causing pituitary desensitization followed by hMG stimulation (group B). Three hundred two cycles were randomly allocated to each group. Cancellation rate was 27.2% in group A compared with only 3.3% in group B. Significantly less hMG ampules for a shorter period were needed in group A patients. Lower estradiol and higher luteinizing hormone levels were detected in the hMG group. Patients in group B yielded significantly more oocytes and more embryos per retrieval. A significantly higher pregnancy rate per cycle was obtained in group B (27%) as compared with that of group A (13%). Moderate and severe ovarian hyperstimulation syndrome was significantly more frequent in group B than in group A.
Ron-El
R
R
Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Sackler School of Medicine, Tel Aviv University, Israel.
Herman
A
A
Golan
A
A
Nachum
H
H
Soffer
Y
Y
Caspi
E
E
D000328:Adult; D004357:Drug Synergism; D004958:Estradiol / Q000032:analysis; D005260:Female; D005306:Fertilization / Q000187:drug effects; D005307:Fertilization in Vitro / Q000379:methods; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007986:Luteinizing Hormone / Q000032:analysis; D008596:Menotropins / Q000494:pharmacology*; D008597:Menstrual Cycle / Q000187:drug effects*; D006080:Ovarian Follicle / Q000187:drug effects; D010053:Ovary / Q000378:metabolism; D010062:Ovulation Induction / Q000379:methods*; D011374:Progesterone / Q000032:analysis; D011446:Prospective Studies
D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone