title: Plasminogen activator inhibitor in acute stroke.
abstract: Plasminogen activator inhibitor activity was determined in patients (26 men, 6 women) with acute ischemic stroke (n = 28) and transient ischemic attack (TIA) (n = 4). Age-matched patients (22 men, 10 women) with various nonvascular neurologic diseases served as controls. Plasma levels of plasminogen activator inhibitor activity were significantly higher in the stroke group (p less than 0.003). Serum triglycerides and plasminogen activator inhibitor activity correlated positively in the stroke group (p less than 0.03) and in controls (p less than 0.0001). Our data suggest a possible involvement of plasminogen activator inhibitor activity in the pathophysiology of stroke.
authors.affiliation: Department of Neurology, University of Essen, Germany.
authors.forename: M J
authors.initials: MJ
authors.lastname: Brockmann
authors.forename: G
authors.initials: G
authors.lastname: Schwendemann
authors.forename: T W
authors.initials: TW
authors.lastname: Stief
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood; D002561:Cerebrovascular Disorders / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood; D008297:Male; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D015849:Plasminogen Inactivators; D014280:Triglycerides; D002784:Cholesterol