Monoterpenic fragment analogues of aplasmomycin as potential antimalarial.
Seven analogues of monoterpenic fragment of aplasmomycin were synthesized as targeted antimalarial agents. The potency of the compound 6 was comparable with the sesquiterpene lactone artemisinin and the antibiotic aplasmomycin in vivo against Plasmodium berghei yoelli.
Balu
N
N
Department of Chemistry, Indian Institute of Technology, Powai, Bombay.
Thomas
J V
JV
Bhat
S V
SV
D000818:Animals; D000900:Anti-Bacterial Agents; D000962:Antimalarials; D007476:Ionophores; D008297:Male; D051379:Mice; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D010962:Plasmodium berghei / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D007476:Ionophores; D010455:Peptides; D013729:Terpenes; C013401:aplasmomycin