Effect of massive small bowel resection on gastric acid secretion in the rat.
The phenomenon of a transitory gastric acid hypersecretory state after extensive bowel resection is well established. Its time of onset, however, is unknown. The purpose of this study was to determine the immediate effect of massive small bowel resection (MSBR) on gastric acid secretion (GAS). An anesthetized innervated rat model was prepared with gastric and jugular cannulae. Three groups of animals were studied: group I (n = 12), basal unstimulated state; group II (n = 12), pentagastrin (Pg) 16 micrograms/kg h-1 stimulated; and group III (n = 16), 5% liver extract meal (LEM) stimulated. Each group consisted of experimental animals that underwent 95% MSBR from proximal jejunum to terminal ileum and control animals that remained intact. Acid output was determined by extragastric titration with 0.1 M NaOH. Blood was taken for basal and postprandial serum gastrin levels. Basal acid output (mueq/10 min) significantly increased immediately after MSBR in all groups (p less than .01). Ninety minutes following MSBR, acid outputs were significantly elevated in basal and Pg-stimulated but not LEM-stimulated rats. Serum gastrin increased from 30 +/- 1 to 56 +/- 6 pg/mL (p less than .01) in group I rats and from 81 +/- 28 to 129 +/- 13 pg/mL in group III rats (p = NS). We conclude that GAS increases immediately after MSBR in group I and II rats. This increase in GAS may be mediated by gastrin release.
Hsiang
Y
Y
Department of Surgery, University of British Columbia, Vancouver, Canada.
Seal
A
A
D000818:Animals; D005502:Food; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D007421:Intestine, Small / Q000601:surgery*; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D005755:Gastrins; D010418:Pentagastrin