B-cell selection and tolerance.
The B-lymphocyte repertoire can be divided into a primary repertoire of virgin B cells and a secondary repertoire of antigenically experienced cells. Self-tolerance requires that neither of these repertoires contains potentially active cells capable of high-affinity, anti-self antibody production. Recent work has proven that both the primary and the secondary repertoire can be functionally purged, and this mechanism may involve failure of appearance of anti-self clonotypes (clonal abortion) or defects in activation (clonal anergy).
Nossal
G J
GJ
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
D000818:Animals; D030801:Animals, Genetically Modified; D001402:B-Lymphocytes / Q000276:immunology*; D007108:Immune Tolerance / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D008954:Models, Biological; D009113:Muramidase / Q000235:genetics
D007143:Immunoglobulin Heavy Chains; D007145:Immunoglobulin kappa-Chains; D009113:Muramidase