Energy reactions in atherosclerosis: the implication of tricarboxylates in the pathogenesis of the disease.
Acetyl CoA is the origin of steroid synthesis and the carbon atoms of the acetate provide the molecular basis for all endogenous cholesterol. Citrate, by virtue of its feedback to acetyl CoA in decreased metabolic respiration, may influence steroid synthesis as it does lipogenesis. It is therefore conceivable that endogenous and possibly exogenous citrates may be important in regulating cholesterol synthesis and its pathological consequence, vascular occlusion.
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D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis; D002951:Citrates / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D008954:Models, Biological; D014233:Tricarboxylic Acids / Q000378:metabolism
D002951:Citrates; D014233:Tricarboxylic Acids; D002784:Cholesterol