title: Fabrication and biocompatibility of a porous bioglass ceramic in a Na2O-CaO-SiO2-P2O5 system.
abstract: A porous bioglass ceramic was prepared from a finely pulverized bioglass powder mixed with particles of two sizes (5 and 500 microns) of 30% by weight with the foaming agent polyethylene glycol 4000 (HO (C2H4O) nH). The batch composition of the bioglass was Na2O 12%, CaO 28%, SiO2 50% and P2O5 10% by weight. The specimens, formed by pressing, were sintered in a high temperature furnace. In this study we are concerned with the preparation and microstructure of the material and its performance in biological tests. The microstructure and crystalline phases of the material were investigated by differential thermal analysis, X-ray diffraction analysis, transmission electron microscopy and scanning electron microscopy. In a biomedical examination, it was shown that the porous material was compatible with animal tissues. The microstructure of the implant indicated that newly grown bone interlocked well with the glass ceramic and that macropores and micropores were distributed uniformly in the material, which provided channels for bone ingrowth and improved the microscopic bioresorption.
authors.affiliation: Center for Biomedical Engineering, College of Medicine, National Taiwan University, Taipei, Republic of China.
authors.forename: F H
authors.initials: FH
authors.lastname: Lin
authors.forename: Y Y
authors.initials: YY
authors.lastname: Huang
authors.forename: M H
authors.initials: MH
authors.lastname: Hon
authors.forename: S C
authors.initials: SC
authors.lastname: Wu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002516:Ceramics / Q000138:chemical synthesis* / Q000737:chemistry; D003460:Crystallization; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006358:Hot Temperature; D016348:Osseointegration / Q000502:physiology; D010316:Particle Size; D019736:Prostheses and Implants; D011817:Rabbits; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains; D012782:Shoulder / Q000000981:diagnostic imaging / Q000601:surgery; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; C022107:Bioglass