Experimental candidosis in pregnant mice.
Pregnant mice were challenged intravenously with doses of 1 x 10(3)-1 x 10(7) Candida albicans blastospores, and from postmortem histopathology it was found that C. albicans had a propensity for localization in the murine placenta. At the highest dose, blastospores, hyphae and pseudohyphae were randomly located in the foeto-placental units, whereas proliferation of fungi at lower doses started in the rim of the placental disc, after which it spread along Reichert's membrane and/or the splanchnopleure, eventually attacking the foetal skin. These findings are analogous to our previous observations on the nature of Aspergillus fumigatus infection in pregnant mice.
Jensen
H E
HE
Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Hau
J
J
Aalbaek
B
B
Schønheyder
H
H
D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000473:pathology*; D005260:Female; D005315:Fetal Diseases / Q000382:microbiology / Q000473:pathology; D006321:Heart / Q000382:microbiology; D007249:Inflammation; D007668:Kidney / Q000382:microbiology / Q000473:pathology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000473:pathology; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology*