[The activating action of mercaptobenzimidazole derivatives on peritoneal macrophages].
It was established that derivatives of mercaptobenzimidazole (bemitil, methoxybemitil, 5-ethoxy-2-ethylmercaptobenzimidazole hydrochloride) in a dose of 25 mg/kg stimulate the mouse peritoneal macrophages by increasing their phagocytic activity and phagocytosis index. Among the studied agents 5-ethoxy-2-ethylmercaptobenzimidazole hydrochloride possesses the greatest effect. The increase of phagocytosis processes was shown to be accompanied with a growth of the number of macrophages reducing nitroblue tetrazolium in diphormazan and with an enhancement of secretion of lysosomal enzymes.
Ratnikov
V I
VI
Ratnikova
L I
LI
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis / Q000187:drug effects; D013268:Stimulation, Chemical
D001562:Benzimidazoles; C070763:5-ethoxy-2-ethylmercaptobenzimidazole; C030698:2-mercaptobenzimidazole; C049825:bemethyl; C070764:methoxybemitil
Aktiviziruiushchee vozdeĭstvie proizvodnykh merkaptobenzimidazola na peritoneal'nye makrofagi.