[Activation of lipid peroxidation in the liver mitochondria and acute toxicity of chemical compounds].
The effect of toxic substances on the functional state of liver mitochondria has been studied. It has been shown, that the contact of toxic substances with mitochondria lead to the reduction of the degree of association of oxidation with phosphorylation. EDTA in concentrations necessary to inhibit lipid peroxide oxidation prevents toxic effects. Preliminary antioxidant treatment of mitochondria prevents toxic damage of membranes. A close correlation has been established between chemical compounds toxicity and the concentration of antioxidants necessary for the prevention of toxic effects, as well as between chemical compounds toxicity and cumulation of malonic dialdehyde in mitochondria membranes.
MItrokhin
N M
NM
Zhigacheva
I V
IV
Chamorovskaia
L T
LT
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D004195:Disease Models, Animal; D004492:Edetic Acid / Q000494:pharmacology*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats; D012997:Solvents / Q000633:toxicity*
D000975:Antioxidants; D012997:Solvents; D004492:Edetic Acid
Aktivatsiia perekisnogo okisleniia lipidov v mitokhondriakh pecheni i ostraia toksichnost' khimicheskikh soedineniĭ.