title: [Presence of specific mutation of Ha-ras oncogene in skin tumors of mice induced under different experimental conditions].
abstract: The mutation was revealed with substitution of A for T in the second position of the 61 Ha-ras oncogene codon in the DNA of 31 skin tumours (26 papillomas and 5 carcinomas) and in 23 mice treated with 12-O-tetradecanoyl phorbol-13-acetate (TPA). Part of these mice were F progeny (n-6) and F progeny (n-4) following DMBA administration during pregnancy, another part F progeny (n-5) following ENU action on males prior to mating, the rest mice (n-3) did not undergo additional actions. The mutation under study was revealed only in 3 out of 5 papillomas and in all 5 carcinomas of mice subjected to DMBA administration during pregnancy.
authors.forename: A S
authors.initials: AS
authors.lastname: Loktionov
authors.forename: I G
authors.initials: IG
authors.lastname: Popovich
authors.forename: M A
authors.initials: MA
authors.lastname: Zabezhinskiĭ
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced / Q000235:genetics*; D003062:Codon; D005260:Female; D011905:Genes, ras; D008297:Male; D051379:Mice; D009154:Mutation; D010212:Papilloma / Q000139:chemically induced / Q000235:genetics*; D011247:Pregnancy; D012878:Skin Neoplasms / Q000139:chemically induced / Q000235:genetics*; D013755:Tetradecanoylphorbol Acetate
chemical_list: D003062:Codon; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate
vernacular_title: Prisutstvie spetsificheskoĭ mutatsii onkogena Ha-ras v opukholiakh kozhi mysheĭ, indutsirovannykh v razlichnykh éksperimental'nykh usloviiakh.