[Effect of adaptation to periodic hypoxia on post-infarction fall of blood pressure and hyperactivation of the endothelium].
Acute stress concomitant to the experimental myocardial infarction has induced endothelial hyperactivation of the rat aorta exhibited in an increase of inhibition of norepinephrine-induced contractions of vascular smooth muscle, enhanced endothelium-dependent relaxation correlating with a fall of systemic blood pressure. Preliminary adaptation of rats to intermittent hypobaric hypoxia greatly prevented the stress-induced endothelial hyperactivation and beneficially affected the postinfarction time course of blood pressure.
Manukhina
E B
EB
Lapshin
A V
AV
Meerson
F Z
FZ
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001011:Aorta / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006973:Hypertension / Q000517:prevention & control*; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D010507:Periodicity; D051381:Rats; D011919:Rats, Inbred Strains
Vliianie adaptatsii k periodicheskoĭ gipoksii na postinfarktnoe padenie davleniia i giperaktivatsiiu éndoteliia.