Transdermal nitrate therapy: bioavailability during exercise increases transiently after the daily change of patch.
Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001). The two nitrate-concentration curves differed significantly (P less than 0.0001). Thus, change of patch augmented nitrate availability during exercise.
Gjesdal
K
K
Oslo University Hospital Ullevål, Department of Cardiology, Norway.
Klemsdal
T O
TO
Rykke
E O
EO
Bredesen
J E
JE
D000279:Administration, Cutaneous; D000328:Adult; D001682:Biological Availability; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use
D005996:Nitroglycerin