title: A case of gastric plasmacytoma: genetic analysis and immunofixation electrophoresis.
abstract: A case of early gastric plasmacytoma in a 66-yr-old woman is reported. The demonstration of monotypic IgM lambda immunoglobulin in plasma cells infiltrating the gastric antrum contributed the histological diagnosis. Genetic analysis of the tumor cells confirmed the presence of a monoclonal neoplastic population of plasma cells in the tumor. Monoclonal immunoglobulin (IgM lambda) was demonstrated in serum, not by conventional immunoelectrophoresis, but by a highly sensitive immunofixation electrophoresis technique. Serum monoclonal immunoglobulin disappeared after subtotal gastrectomy. The value of immunofixation electrophoresis of serum protein and DNA analysis of tumor cells was emphasized for the diagnosis of gastric plasmacytoma.
authors.affiliation: Department of Internal Medicine, Miki City Hospital, School of Allied Medical Sciences, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: C
authors.initials: C
authors.lastname: Kawanami
authors.forename: K
authors.initials: K
authors.lastname: Kishi
authors.forename: N
authors.initials: N
authors.lastname: Kitajima
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Inatome
authors.forename: T
authors.initials: T
authors.lastname: Inoh
mesh_terms: D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D007075:Immunoglobulin M / Q000032:analysis*; D007142:Immunoglobulin gamma-Chains / Q000032:analysis*; D010954:Plasmacytoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm; D007075:Immunoglobulin M; D007142:Immunoglobulin gamma-Chains