title: Synthesis and pharmacological evaluation of pyrazolopyrimidobenzoxazole and pyrazolopyrimidobenzothiazole derivatives.
abstract: As a part of research on polieterocycles compounds with condensed nuclei, containing pyrimidine ring, as potential antalgic/anti-inflammatory drugs, pyrazolopyrimidobenzoxazole and pyrazolopyrimidobenzothiazole were prepared and tested. None of the substances shows significative activities in vivo.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania.
authors.forename: F
authors.initials: F
authors.lastname: Russo
authors.forename: S
authors.initials: S
authors.lastname: Guccione
authors.forename: G
authors.initials: G
authors.lastname: Romeo
authors.forename: L
authors.initials: L
authors.lastname: Monsù Scolaro
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: V
authors.initials: V
authors.lastname: Cutuli
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001583:Benzoxazoles; D011720:Pyrazoles; D011725:Pyridines; D013844:Thiazoles