title: Clinical effects of methamphetamine vapor inhalation.
abstract: Despite the increasing popularity of crystalline methamphetamine ("ice") vapor inhalation, no investigations have reported drug plasma concentrations and effects. Under controlled laboratory conditions, six subjects were studied. Plasma concentrations of methamphetamine were determined, and subjective and cardiovascular effects were measured. Methamphetamine appeared in plasma rapidly, increased slowly over the next four hours and then progressively declined. The dose of methamphetamine administered produced modest ratings of subjective drug effects, and moderate changes in cardiovascular parameters. Both subjective and cardiovascular effects rapidly decreased despite the presence of sustained concentrations of methamphetamine in plasma.
authors.affiliation: Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill.
authors.forename: M
authors.initials: M
authors.lastname: Perez-Reyes
authors.forename: W R
authors.initials: WR
authors.lastname: White
authors.forename: S A
authors.initials: SA
authors.lastname: McDonald
authors.forename: J M
authors.initials: JM
authors.lastname: Hill
authors.forename: A R
authors.initials: AR
authors.lastname: Jeffcoat
authors.forename: C E
authors.initials: CE
authors.lastname: Cook
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors
chemical_list: D008694:Methamphetamine