title: Comparison of a phenolic and a 0.2% chlorhexidine mouthwash on the development of plaque and gingivitis.
abstract: Chlorhexidine and phenolic mouthrinses have attracted considerable interest as adjuncts to oral hygiene. The aim of this study was to compare two well known proprietary mouthrinse products for their effects on plaque regrowth, the development of gingivitis and the formation of toothstaining. The study was a single-blind, randomized, placebo-controlled, triple cross-over experimental, gingivitis design. A group of 15 volunteers with a very high standard of oral hygiene and gingival health used each rinse for 19 days in the absence of normal toothcleaning. Each period was separated by a 21 day washout. Plaque scores were significantly different between the rinses, being lowest with chlorhexidine and highest with saline. The plaque area increased 3-fold with the phenolic rinse and 6-fold with the saline rinse compared to the chlorhexidine rinse. Similarly, gingivitis increments were lowest with chlorhexidine and highest with saline but differences between rinses did not reach significance. Staining was significantly different between rinses, primarily due to minimal staining associated with the saline rinse. Staining occurred with both the chlorhexidine and phenolic mouthrinses. It is concluded that the 0.2% chlorhexidine rinse offers greater oral hygiene benefits than the phenolic rinse. The question of indications and durations of use of mouthwash products should be addressed.
authors.affiliation: Department of Periodontology, Dental School, University of Wales College of Medicine, Cardiff.
authors.forename: J
authors.initials: J
authors.lastname: Moran
authors.forename: D
authors.initials: D
authors.lastname: Pal
authors.forename: R
authors.initials: R
authors.lastname: Newcombe
authors.forename: M
authors.initials: M
authors.lastname: Addy
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002710:Chlorhexidine / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use*; D010512:Periodontal Index; D010636:Phenols / Q000627:therapeutic use*; D016037:Single-Blind Method
chemical_list: D009067:Mouthwashes; D010636:Phenols; D002710:Chlorhexidine