title: Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family.
abstract: The two alternative carboxyl-termini of Shaker K+ channels strongly influence the rates of inactivation and of recovery from channel inactivation. We show that this distinct inactivation behaviour is due to an alanine/valine amino acid replacement within the Shaker carboxyl-terminus at a site that occurs within the proposed membrane spanning segment S6.
authors.affiliation: Ruhr-Universität Bochum, Lehrstuhl für Biochemie, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Wittka
authors.forename: M
authors.initials: M
authors.lastname: Stocker
authors.forename: G
authors.initials: G
authors.lastname: Boheim
authors.forename: O
authors.initials: O
authors.lastname: Pongs
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002462:Cell Membrane / Q000378:metabolism; D004247:DNA; D004252:DNA Mutational Analysis; D004331:Drosophila melanogaster; D004594:Electrophysiology; D007700:Kinetics; D008969:Molecular Sequence Data; D015221:Potassium Channels / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment
chemical_list: D015221:Potassium Channels; D004247:DNA