title: Intramitochondrial formation of oxidized glutathione during the oxidation of benzylamine by monoamine oxidase.
abstract: Oxidation of benzylamine by MAO results in an accumulation of GSSG in mouse liver mitochondria. Formation of GSSG is prevented by deprenyl, an inhibitor of MAO-B, but not by catalase. GSSG accumulation also occurs with dopamine as substrate. Oxidation of monoamines by mitochondrial MAO represents a potential oxidant stress for mitochondria.
authors.affiliation: Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029.
authors.forename: P
authors.initials: P
authors.lastname: Werner
authors.forename: G
authors.initials: G
authors.lastname: Cohen
mesh_terms: D000818:Animals; D001596:Benzylamines / Q000378:metabolism*; D003010:Clorgyline / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism*; D012642:Selegiline / Q000494:pharmacology; D013379:Substrate Specificity
chemical_list: D001596:Benzylamines; D012642:Selegiline; C030796:benzylamine; D006861:Hydrogen Peroxide; D008995:Monoamine Oxidase; D005978:Glutathione; D003010:Clorgyline