Effects of indomethacin on prostaglandin E2 and thromboxane B2 contents of tracheal lavage fluids in premature infants.
A prospective longitudinal study was conducted in 14 premature infants intubated and receiving ventilatory support from birth, in order to evaluate the levels of prostaglandins E2 (PGE2) and thromboxane B2 (TxB2) in the tracheal lavage fluids (TLF) after treatment with indomethacin. Eight were treated with indomethacin, a cyclooxygenase inhibitor, for patient ductus arteriosus and the others served as controls. Infants who received indomethacin during the first postnatal week had significantly lower levels of eicosanoids in TLF during the first week. Our results suggest that levels of eicosanoids in TLF of premature infants are related to an inflammatory reaction and may serve as an index of the infant's overall clinical condition.
Le Guennec
J C
JC
Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, P. Q. Canada.
Lauzière
M
M
Black
R
R
Sirois
P
P
D001826:Body Fluids / Q000737:chemistry; D016861:Cyclooxygenase Inhibitors; D015232:Dinoprostone / Q000378:metabolism*; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology* / Q000627:therapeutic use; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D007249:Inflammation; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D011446:Prospective Studies; D007507:Therapeutic Irrigation; D013929:Thromboxane B2 / Q000378:metabolism*; D014132:Trachea / Q000187:drug effects / Q000293:injuries / Q000378:metabolism*
D016861:Cyclooxygenase Inhibitors; D013929:Thromboxane B2; D015232:Dinoprostone; D007213:Indomethacin