New 6-cyano-3-phenyl-1-,2,3,4-tetrahydro-1,2-diazepin-5-ones: synthesis and in vitro antitumor activity evaluation.
A series of 6-cyano-3-phenyl-1,2,3,4-tetrahydro-1,2-diazepin-5-ones were synthesized and evaluated in vitro as antitumor agents against several human tumor cell lines. Moderate activity and differential cellular sensitivity were found for a few of the tested compounds.
Dal Piaz
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V
Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università di Firenze.
Ciciani
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G
Giovannoni
M P
MP
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D001381:Azepines