title: Impaired immune responsiveness is an essential component in persistent central nervous system infection with gross murine leukemia virus.
abstract: Exposure of newborn mice to Gross murine leukemia virus (GMuLV) results in persistent viral infection of the central nervous system (CNS) white matter. Animals exposed to virus as neonates showed a marked depression in GMuLV-specific B lymphocyte function as evidenced by significant decreases in adult and neonatal anti-GMuLV antibody levels. Immunohistochemical analyses showed that the sites of GMuLV infection in the CNS were also devoid of major histocompatibility complex (MHC) class I and II protein expression, although transplantation of GMuLV-infected brain tissue to the kidney capsules of immunocompetent mice induced a potent mononuclear cell graft infiltrate. These results indicate that persistent GMuLV infection of the CNS is linked to both impairment of anti-GMuLV peripheral immune responses and deficient antigen-presenting cell function within the CNS.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104.
authors.forename: J M
authors.initials: JM
authors.lastname: Korostoff
authors.forename: M T
authors.initials: MT
authors.lastname: Nakada
authors.forename: J F
authors.initials: JF
authors.lastname: Markman
authors.forename: G N
authors.initials: GN
authors.lastname: Gaulton
mesh_terms: D000406:AKR murine leukemia virus; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D000917:Antibody Formation; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex / Q000032:analysis; D002493:Central Nervous System Diseases / Q000503:physiopathology*; D006649:Histocompatibility Antigens / Q000032:analysis; D007107:Immune System / Q000503:physiopathology*; D007108:Immune Tolerance; D007942:Leukemia, Experimental / Q000097:blood / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012190:Retroviridae / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D006649:Histocompatibility Antigens