title: [Reasons for the persistent lethality of malignant hyperthermia and recommendations for its reduction].
abstract: Dantrolene is the only known specific treatment of malignant hyperthermia (MH). Following official approval an intravenous formulation of dantrolene became clinically available for emergency treatment of MH. At that time it had been anticipated, that with dantrolene therapy combined with constant vigilance each case of MH could be treated successfully and the mortality rate should be close to zero. Surprisingly enough, reports of death due to MH continue to be published up to the present. Analysis of case reports revealed the following reasons for the discrepancy between the expectations and the clinical reality: 1. Delay in early diagnosis due to preoccupation with the name-giving symptom hyperthermia: lack of MH-sensitive monitoring (i.e. capnometry, pulse oximetry, blood gas analysis). 2. Preoccupation with non specific facets of therapy: measures such as cooling, change of the anaesthesia machine, transfer of the patient to the intensive care unit or the administration of drugs which have been shown to be ineffective in treating MH may not only be a waste of time, but fully disregard the prime factor in therapy--intravenous administration of dantrolene. 3. Administration of an insufficient amount of dantrolene and delayed start of specific therapy due to failure to have immediate access to intravenous dantrolene. 4. Failure to increase minute ventilation immediately after making the diagnosis to meet elevated metabolic demands. A recommendation is presented how to diagnose, to treat and prevent MH, considering present day diagnostic and therapeutic measures in the presence of the presumptive diagnosis of MH.
authors.affiliation: Klinik für Anaesthesie und Operative Intensivmedizin, StadtischeS Krankenhaus Heilbronn, Akademisches Landeskrankenhaus, Universität Heidelberg.
authors.forename: U
authors.initials: U
authors.lastname: Schulte-Sasse
authors.forename: H J
authors.initials: HJ
authors.lastname: Eberlein
mesh_terms: D000758:Anesthesia / Q000379:methods; D003620:Dantrolene / Q000008:administration & dosage; D006801:Humans; D008305:Malignant Hyperthermia / Q000401:mortality* / Q000517:prevention & control; D016343:Monitoring, Intraoperative / Q000379:methods
chemical_list: D003620:Dantrolene
vernacular_title: Gründe für die persistierende Letalität der Malignen Hyperthermie und Empfehlungen zu deren Senkung.