Immunization against Schistosoma mansoni by using Trichinella spiralis and Trichinella pseudospiralis antigens.
The antigenic fraction of a cell free homogenate of each of Trichinella spiralis and T. pseudospiralis were prepared to be used for induction of immunity against S. mansoni in albino mice. The results of the study showed that immunization with either of the two antigens induced reduction in worm load ranging from 80.48% to 87.86% in the different groups of the study. Reduction in tissue egg count was also reported: Liver egg count was reduced from 69.47% to 100%. Intestinal egg count reduction ranged from 73.83% to 99.78%. There was also reduction in egg excretion as evidenced by diminution in stool egg count. Liver granulomas were less in number and size and showed accelerated reaction together with inhibition of fluorescence. These findings were more manifest in animals given T. spiralis than T. pseudospiralis antigen.
Youssef
M M
MM
Department of Parasitology, Faculty of Medicine, Alexandroa University, Egypt.
Abu Samra
L M
LM
Hegazy
I H
IH
D000818:Animals; D000947:Antigens, Helminth / Q000627:therapeutic use*; D007114:Immunization; D008099:Liver / Q000469:parasitology; D051379:Mice; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000517:prevention & control*; D014234:Trichinella / Q000276:immunology*
D000947:Antigens, Helminth