[[Elimination of toxins from the body using electrochemical oxidation].
Potentialities of electrochemical procedures were considered in simulation of liver monooxygenases functions directed to clearance of blood and tissues from toxic and ballast substances by means of hydroxylating oxidation. Electrooxidation of specific endogenous toxin bilirubin, catalyzed by platinum electrode, was studied in model physiological solutions, blood, lymph and blood plasma. Three problems developed during direct electrooxidation of toxins in blood: efficiency of electrochemical cell, "protein protection" of the toxin, compatibility of electrochemical cell and blood. Influences of electrochemical oxidation on various patterns of intact animal homeostasis were studied as well as efficiency of the oxidation in a body was shown. Artificial detoxicating system was elaborated for clinical purpose using these experimental data.
Vasil'ev
Iu V
IuV
Sergienko
V I
VI
Grinberg
V A
VA
Martynov
A K
AK
D000418:Albumins / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D004563:Electrochemistry; D006801:Humans; D008099:Liver / Q000201:enzymology; D008657:Metabolic Clearance Rate; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010084:Oxidation-Reduction; D014118:Toxins, Biological / Q000378:metabolism*
D000418:Albumins; D014118:Toxins, Biological; D006899:Mixed Function Oxygenases; D001663:Bilirubin
Udalenie toksinov iz organizma s pomoshch'iu élektrokhimicheskogo okisleniia.