title: Isodicentric chromosome 18q as sole abnormality in a histologically normal bone marrow from a patient with diffuse large-cell non-Hodgkin's lymphoma.
abstract: Cytogenetic analysis was performed on the histologically and immunophenotypically normal bone marrow (BM) of a 33-year-old woman with non-Hodgkin's lymphoma (NHL) before BM harvest. Unstimulated 24- and 48-hour cultures produced only normal metaphases. A pokeweed mitogen (PWM)-stimulated 48-hour culture, however, showed a clonal isodicentric chromosome 18q as the sole abnormality, suggesting a role for this approach in detection of submicroscopic BM involvement by B-cell NHL.
authors.affiliation: Dartmouth-Hitchcock Medical Center, Durham, North Carolina.
authors.forename: D H
authors.initials: DH
authors.lastname: Wurster-Hill
authors.forename: J J
authors.initials: JJ
authors.lastname: Vredenburgh
authors.forename: B H
authors.initials: BH
authors.lastname: Davis
authors.forename: L E
authors.initials: LE
authors.lastname: Mills
authors.forename: E D
authors.initials: ED
authors.lastname: Ball
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000473:pathology