title: Competition between strains of Escherichia coli with and without plasmid RP4 during chemostat growth.
abstract: Escherichia coli strains J53(nal) and J53(RP4) were grown together in glucose-limited continuous cultures. Based on the measured growth kinetic constants of the two strains, take-over of the cultures by J53(RP4) was predicted. However, in practice, an initial period of predominance by J53(RP4) was always followed by a prolonged period in which relative numerical proportions of the two strains oscillated widely. This period of oscillation was removed or greatly reduced when the difference between the predicted growth-rate potentials of the two strains was increased by selection of a chemostat-adapted variant of J53(RP4).
authors.affiliation: School of Pure and Applied Biology, University of Wales College of Cardiff.
authors.forename: Z
authors.initials: Z
authors.lastname: Numan
authors.forename: W A
authors.initials: WA
authors.lastname: Venables
authors.forename: J W
authors.initials: JW
authors.lastname: Wimpenny
mesh_terms: D003227:Conjugation, Genetic; D004352:Drug Resistance, Microbial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007700:Kinetics; D009268:Nalidixic Acid / Q000494:pharmacology; D011815:R Factors
chemical_list: D009268:Nalidixic Acid; D005947:Glucose