Effect of ethanol perfusion on creatinine removal in a Roux-Y intestinal segment.
Five rats and 2 goats had a bypass operation to allow infusion of sorbents through an inlet ostomy. The sorbents passed through one limb of intestine isolated from food contact to join a food limb which included 30-40% of the original length of small intestine. In goats, serum creatinine levels were elevated by infusion of sterile creatinine solutions intravenously. Twenty-four hour urines were collected before, during and after periods of infusion of sorbents into the inlet ostomy. Infusion of charcoal into the ostomy had little effect on the total daily urinary creatinine excretion (TDUC). However infusion of 4.3 g/kg/day ethanol decreased the TDUC significantly, in both species. In rats, 8.6 g/kg/day ethanol infusion had an even greater effect on TDUC. Studies of intraluminal creatinine concentration in the distal part of the sorbent segment indicated that especially when serum concentration of creatinine is over 2 mg%, ethanol greatly increases the intraluminal creatinine concentration in the intestine. It is concluded that ethanol, in combination with intestinal sorbents or alone, could allow intestinal dialysis to remove considerably more creatinine, and possibly aid transport of other organic substances.
Koszuta
J J
JJ
Indiana University School of Medicine, Indianapolis.
Carter
J M
JM
Ash
S R
SR
D000713:Anastomosis, Roux-en-Y; D000818:Animals; D001693:Biological Transport, Active; D002606:Charcoal / Q000494:pharmacology; D003404:Creatinine / Q000378:metabolism*; D003956:Dialysis; D000431:Ethanol / Q000494:pharmacology*; D006041:Goats; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism* / Q000601:surgery; D010477:Perfusion; D051381:Rats; D016060:Sorption Detoxification
D002606:Charcoal; D000431:Ethanol; D003404:Creatinine