Assessment of water and solute absorption from experimental hypotonic and established oral rehydration solutions in secreting rat intestine.
Water and solute absorption from three experimental hypotonic oral rehydration solutions (HYPO-ORS; sodium 45, 60 and 75 mmol/L, glucose 90 mmol/L), the World Health Organization recommended ORS (WHO-ORS; sodium 90 mmol/L, glucose 111 mmol/L), and the British National Formulary recommended ORS (BNF-ORS; sodium 35 mmol/L, glucose 200 mmol/L), have been assessed by perfusion studies in cholera toxin-induced secreting rat intestine. Net water absorption was greatest from the most hypotonic solution (HYPO-45; P less than 0.05). UK-ORS prevented net water secretion and WHO-ORS promoted moderate net water absorption. Net sodium secretion was seen with all solutions but was least from WHO-ORS and greatest with BNF-ORS (P less than 0.01). Glucose absorption was similar from BNF-ORS, WHO-ORS and HYPO-45 and in each case was greater than glucose absorption from HYPO-60 and HYPO-75 (P less than 0.05). These results suggest that net water and sodium absorption from ORS may be enhanced if osmolality is reduced by decreasing the glucose content.
Hunt
J B
JB
Department of Gastroenterology, St Bartholomew's Hospital, West Smithfield, London, UK.
Carnaby
S
S
Farthing
M J
MJ
D000818:Animals; D002772:Cholera Toxin / Q000494:pharmacology; D005440:Fluid Therapy; D005947:Glucose / Q000378:metabolism; D007408:Intestinal Absorption; D008297:Male; D009994:Osmolar Concentration; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D015532:Rehydration Solutions / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D014867:Water / Q000378:metabolism*
D015532:Rehydration Solutions; D014867:Water; D002772:Cholera Toxin; D012964:Sodium; D005947:Glucose