[Formation and reversal development of the local mechanisms of heart protection during adaptation to continuous stress].
Experiments with isolated rat hearts demonstrated that in the course of adaptation to continuous immobilized stress of moderate intensity (1, 5, and 15 days), the heart gradually (at day 15) formed the defense mechanism previously described, that is the adaptive structural stabilization phenomenon (ASSP). ASSP defends cardiac contractile function and has a powerful antiarrhythmic and cytoprotective effect in total ischemia, reperfusion, and under the action of toxic concentrations of calcium and catecholamines. The protective ASSP effect formed over 15 days of continuous stress proved to be steady-state, remaining for 15 days of adaptation cessation. Thus, during adaptation to continuous stress higher regulatory mechanisms determine the gradual development of a highly effective defense mechanism in the heart at the cellular level.
Kuznetsov
V I
VI
Saltykova
V A
VA
Meerson
F Z
FZ
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D006321:Heart / Q000503:physiopathology*; D006324:Heart Arrest, Induced; D008297:Male; D008955:Models, Cardiovascular; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000209:etiology / Q000503:physiopathology*; D013997:Time Factors
Formirovanie i obratnoe razvitie lokal'nykh mekhanizmov zashchity serdtsa pri adaptatsii k nepreryvnomu stressornomu vozdeĭstviiu.