title: Acute toxicity of taxine in mice and rats.
abstract: The acute toxicity of taxine isolated from leaves of yew trees was determined in mice and rats. The drug was used as the sulphate salt. The following LD50 values (mg/kg) and 95% confidence limits were found: mice po 19.72 (16.84-23.09); mice ip 21.88 (19.66-24.35); rats sc 20.18 (18.35-22.20).
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Tekol
mesh_terms: D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000633:toxicity*; D010939:Plant Poisoning / Q000150:complications*; D051381:Rats; D043823:Taxoids
chemical_list: D000470:Alkaloids; D010936:Plant Extracts; D043823:Taxoids; C047703:taxine