[Orthotopic liver transplantation at the Island Hospital. Initial experiences 1985-1990].
Between 1985 and 1990 22 orthotopic liver transplantations (OLT) were realized in 19 patients. Active infection and diffuse splanchnic venous thrombosis were the only contra-indications to the intervention. Sixteen patients were transplanted electively; three had to be retransplanted urgently. Three patients had an urgent primary transplant. The incidence of surgical complications related to liver implantation was fair. One patient (5%) developed a late portal vein thrombosis; another patient (5%) had to be retransplanted because of hepatic artery thrombosis. All patients presented one or more major postoperative complications. All, but one, patients had a rejection of the allograft; five of them needed treatment with mono- or polyclonal antilymphocytic sera to reverse the rejection. One patient was retransplanted because of a hyperacute rejection. The six-month survival in this series is 68.5% (13 of 18 patients); one patient died 7 months post-OLT due to a neurological complication of her Wilson disease. Quality of life (from 6 to 64 months post-OLT) is excellent in the 12 long-term survivors. This small experience of the Bernese transplantation program shows that liver transplantation is a safe surgical procedure allowing excellent quality of life in a majority of patients.
Lerut
J P
JP
Klinik für Viszerale und Transplantationschirurgie, Inselspital Bern.
Gertsch
P
P
Luder
P J
PJ
Zimmermann
A
A
Dijkhuis
E A
EA
Rothen
H U
HU
Ott
B
B
Nydegger
U
U
Horber
F
F
Fisch
H U
HU
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology; D006501:Hepatic Encephalopathy / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007165:Immunosuppression Therapy; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation / Q000276:immunology / Q000379:methods* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D012086:Reoperation
Orthotope Lebertransplantation am Inselspital. Erste Erfahrungen während der Periode 1985-1990.