title: Influence of extract of Rosa rugosa roots on lipid levels in serum and liver of rats.
abstract: The effects of the methanol extract of Rosa rugosa roots on serum and liver lipids were studied in rats. The rats were fed the purified diets with or without the methanol extract at the 1% level for 4 weeks. The concentrations of serum and liver total cholesterol were not significantly affected by the feeding of extract. Feeding of the extract, on the other hand, reduced the liver triacylglycerol content without influencing the serum triacylglycerol level. The effects of the extract on lipids profiles were diminished markedly by dietary cholesterol. The results suggest an existence of component in the extract which may ameliorate the accumulation of triacylglycerol in rat liver.
authors.affiliation: Department of Food Science and Technology, Kangweon National University, Chuncheon, Republic of Korea.
authors.forename: S Y
authors.initials: SY
authors.lastname: Lee
authors.forename: J D
authors.initials: JD
authors.lastname: Kim
authors.forename: Y H
authors.initials: YH
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Rhee
authors.forename: Y S
authors.initials: YS
authors.lastname: Choi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000097:blood; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008055:Lipids; D010743:Phospholipids; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol