Fluoxetine-induced suicidality, serotonin, and seasonality.
In spite of the complexities involved in suicide, fluoxetine has been prematurely and simplistically blamed for inducing this phenomenon. A variety of variables must be factored into such an interpretation. Nevertheless, given the complicated psychobiological circumstances involved, acute and rapid changes in serotonin (5-HT) function appear to be important to the understanding of changes in suicidal behavior. Such a mechanism may also explain the robust seasonal peak of suicides in spring.
Brewerton
T D
TD
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425-0742.
D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012307:Risk Factors; D012621:Seasons; D012701:Serotonin / Q000502:physiology*; D013405:Suicide / Q000523:psychology*
D005473:Fluoxetine; D012701:Serotonin