title: [Studies on manifestations of Rh-related hemolytic disease of the newborn in the years 1974-1989 in the Erfurt district].
abstract: In the course of 13 years (1977-1989) 223 of 223,121 liveborn infants in the district of Erfurt suffered from haemolytic disease due to Rh-isoimmunization, 0.1 per cent died. An initial drop of morbidity from 1.6 to 0.6 of 1000 newborns was followed by stagnation and further increase during the last years. More than 50% of the affected babies were delivered by women who had to be protected from sensibilization by immune prophylaxis. The cause for the immunization were deliveries (75%), miscarriages and interruptions (23%). The most important reason for the insufficient decrease of the Rh-morbidity is the failure of immune prophylaxis in the case of ABO-incongruence between mother and child. Our results support the demands for a general immune prophylaxis without taking into consideration the main blood groups and the number and result of the pregnancy. The quantity of severe erythroblastosis (7 stillborn and 5 hydropic liveborn) demonstrates the necessity to improve the prenatal management of these babies.
authors.affiliation: Klinik und Poliklinik für Kindermedizin, Medizinischen Akademie Erfurt.
authors.forename: B
authors.initials: B
authors.lastname: Töpke
authors.forename: K
authors.initials: K
authors.lastname: Menzel
authors.forename: R
authors.initials: R
authors.lastname: Uhlig
authors.forename: U
authors.initials: U
authors.lastname: Pfister
mesh_terms: D000028:Abortion, Induced / Q000009:adverse effects; D000022:Abortion, Spontaneous / Q000150:complications; D004899:Erythroblastosis, Fetal / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D005260:Female; D005859:Germany, East / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011295:Prenatal Care; D012203:Rh Isoimmunization / Q000209:etiology / Q000517:prevention & control
vernacular_title: Untersuchungen über das Auftreten des Rh-bedingten Morbus hämolyticus neonatorum in den Jahren 1974-1989 im Bezirk Erfurt.