Nonrandom t(1;22)(p12-p13;q13) in acute megakaryocytic malignant proliferation.
A case of acute megakaryocytic leukemia (M7) and one of acute myeloid hemopathy affecting megakaryocytic and erythrocytic cell lineages in infants are reported. Both patients had t(1;22)(p12-p13;q13). This translocation was previously observed in a congenital M7 leukemia. These studies suggest that t(1;22) translocation can be nonrandom in M7.
Baruchel
A
A
Service D'Hématologie Pédiatrique, Hôpital Saint-Louis, Paris, France.
Daniel
M T
MT
Schaison
G
G
Berger
R
R
D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007223:Infant; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic