Serum poly(A)polymerase levels in rats during induction of mammary carcinoma with 7,12-dimethylbenz[a]anthracene.
Levels of activity of poly(A)polymerase (polynucleotide adenylyl transferase), the enzyme responsible for the addition of poly(A) tracts to the 3'-termini of eukaryotic mRNAs were assayed in the serum of rats during induction of mammary carcinoma by intragastric administration of 7,12-dimethylbenz[a]anthracene (DMBA, 10 mg/rat). An appreciable rise in the levels of poly(A)polymerase coincided with the growth of palpable DMBA-induced mammary carcinoma, which then dropped sharply 2 weeks later when the tumor incidence reached its peak of 65%.
Barsoum
A L
AL
Department of Microbiology and Immunology, University of South Alabama, Mobile 36688.
Kurl
R N
RN
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D011062:Polynucleotide Adenylyltransferase / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D015127:9,10-Dimethyl-1,2-benzanthracene; D011062:Polynucleotide Adenylyltransferase