title: Effect of an oral adsorbent (AST-120) in rats with daunomycin-induced chronic renal failure.
abstract: The effect of an oral adsorbent (AST-120) was examined in rats with daunomycin-induced chronic renal failure. Sixteen pairs of daunomycin rats which had similar levels of proteinuria at 4 weeks after being injected with daunomycin were selected. One rat of each pair served as a control and was fed on a standard diet, while the other rats were fed on a diet containing AST-120. The blood creatinine and blood urea nitrogen (BUN) were significantly lower in the rats fed with AST-120 than in the controls. Moreover, the life span of the rats fed with AST-120 was significantly prolonged as compared to that of the control rats. These findings suggest that oral administration of AST-120 may help to prevent rapid deterioration of renal function in experimental chronic renal failure induced by daunomycin in rats.
authors.affiliation: Aichi Prefectural University, Nagoya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Shibata
authors.forename: M
authors.initials: M
authors.lastname: Ise
authors.forename: M
authors.initials: M
authors.lastname: Sugano
authors.forename: Y
authors.initials: Y
authors.lastname: Uehara
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002244:Carbon / Q000008:administration & dosage / Q000627:therapeutic use*; D003630:Daunorubicin; D005260:Female; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000188:drug therapy*; D010087:Oxides / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010087:Oxides; D002244:Carbon; C040896:AST 120; D003630:Daunorubicin