[The protective activity of the attenuated strain 15 of the Venezuelan equine encephalomyelitis virus in rodent infection via the respiratory tract].
Administration to rodents (Syrian hamsters, mice, guinea pigs, rabbits) of minimal doses of attenuated strain 15 VEE (up to 20 ImD50) provided protection against respiratory challenge with a highly virulent strain of Venezuelan equine encephalomyelitis virus. The protection is observed in a wide range of doses (up to LD50 hundreds and even thousands).
Filatenkov
A G
AG
Khaltaeva
G G
GG
Khlebnikova
N N
NN
Gorban'
S G
SG
Shkurnikova
N N
NN
Khamitova
M F
MF
D000818:Animals; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology* / Q000472:pathogenicity; D004685:Encephalomyelitis, Venezuelan Equine / Q000209:etiology / Q000517:prevention & control*; D006168:Guinea Pigs; D007114:Immunization; D008647:Mesocricetus; D051379:Mice; D011817:Rabbits; D012141:Respiratory Tract Infections / Q000209:etiology / Q000517:prevention & control*; D012376:Rodent Diseases / Q000209:etiology / Q000517:prevention & control*; D012692:Serial Passage; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014774:Virulence
D014613:Vaccines, Attenuated; D014765:Viral Vaccines
Protektivnaia aktivnost' attenirovannogo shtamma 15 virusa venesuél'skogo éntsefalomielita loshadeĭ pri infitsirovanii gryzunov cherez dykhatel'nye puti.