title: Acrolein genotoxicity in Drosophila melanogaster. I. Somatic and germinal mutagenesis under proficient repair conditions.
abstract: The genotoxicity of acrolein in D. melanogaster was investigated using 2 different SMART assays, the eye spot and wing spot tests, and 2 germinal tests, the sex-linked recessive lethal (SLRLT) and sex chromosome loss (SCLT) tests. For the 2 latter, exposure by feeding as well as injection was used. The results indicate that: (i) acrolein is mutagenic in the SLRLT when injected but not when fed; (ii) the SCLT did not reveal clastogenic effects; (iii) acrolein had genotoxic effects in both SMART assays; (iv) we also had several indications that acrolein is metabolized into a second genotoxic product.
authors.affiliation: Departamento de Biología Funcional, Universidad de Oviedo, Spain.
authors.forename: L M
authors.initials: LM
authors.lastname: Sierra
authors.forename: A R
authors.initials: AR
authors.lastname: Barros
authors.forename: M
authors.initials: M
authors.lastname: García
authors.forename: J A
authors.initials: JA
authors.lastname: Ferreiro
authors.forename: M A
authors.initials: MA
authors.lastname: Comendador
mesh_terms: D000171:Acrolein / Q000633:toxicity*; D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D005804:Genes, Lethal; D005808:Genes, Recessive; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens; D012730:Sex Chromosomes
chemical_list: D009153:Mutagens; D000171:Acrolein