Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation and reformation in the rat model.
The local application of 0.25% or 0.4% HA before the induction of a measured laser injury on the rat uterine horn was associated with a significant reduction (P less than 0.05) in postoperative IP adhesions when compared with the group of animals pretreated with the diluent vehicle PBS or received no pretreatment. However, 0.4% HA, when applied in a similar manner, was ineffective in reducing reformation of adhesions after microsurgical adhesiolysis.
Urman
B
B
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.
Gomel
V
V
D000818:Animals; D005260:Female; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007834:Lasers; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011183:Postoperative Complications; D011292:Premedication; D011833:Radiation Injuries, Experimental / Q000150:complications; D051381:Rats; D011919:Rats, Inbred Strains; D012008:Recurrence; D000267:Tissue Adhesions / Q000517:prevention & control*; D014599:Uterus / Q000293:injuries / Q000473:pathology / Q000528:radiation effects
D006820:Hyaluronic Acid