[Brain protein synthesis in awake rats: equilibrium of L-methionine between plasma and direct precursor pool].
After 1 hr. of continuous infusion of L-(35S)methionine the specific activities of L-methionine in plasma and tissue-free and tRNA-bound L-methionine in brain were in the same range. This result indicates that, under steady-state conditions, dilution of the precursor pool for protein synthesis (L-methionyl-tRNA) by L-methionine derived from a source other than plasma can be considered as negligible.
Grange
E
E
C.N.R.S.-U.R.A. n. 1195, Laboratoire d'Anatomie pathologique, Faculté de Médecine Alexis Carrel, Lyon.
Gharib
A
A
Lepetit
P
P
Guillaud
J
J
Sarda
N
N
Bobillier
P
P
D000818:Animals; D001923:Brain Chemistry; D008297:Male; D008715:Methionine / Q000097:blood / Q000378:metabolism*; D014176:Protein Biosynthesis; D012358:RNA, Transfer, Met / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000378:metabolism
D012358:RNA, Transfer, Met; D008715:Methionine
Biosynthèse des protéines cérébrales chez le rat vigile: équilibre de la L-méthionine entre le plasma et le compartiment précurseur direct.