title: Effects of dietary soya bean trypsin inhibitor concentrate on initiation and growth of putative preneoplastic lesions in the pancreas of the rat.
abstract: Two studies evaluated the effects of soya bean trypsin inhibitor concentrate (STIC) on early stages of pancreatic carcinogenesis in Wistar rats. In experiment 1, the effects of a 3-month administration of diets containing 3.7% STIC were compared with the effects of administration of diets containing 20% corn oil, in rats pretreated with a single azaserine injection sufficient to initiate putative preneoplastic atypical acinar cell foci. Experiment 2 investigated the capacity of STIC to initiate pancreatic carcinogenesis. Diets containing 3.7% STIC were fed for 4 wk, then diets containing either 5 or 20% corn oil were fed for 3 months. Pancreases were quantitatively evaluated for foci. All groups of azaserine-initiated rats had large numbers of atypical acinar cell foci per cm3 of pancreas. Of these, the group fed 3.7% STIC had pancreatic foci that occupied a significantly greater (P less than 0.01) percentage volume of pancreas than did groups fed 20% corn oil or control diets, which contained 5% corn oil and no added trypsin inhibitor. Very few or no foci were observed in all other groups of either experiment 1 or 2. STIC had a much greater effect on the growth of azaserine-induced lesions than did corn oil. STIC alone did not appear to initiate pancreatic lesions.
authors.affiliation: Division of Nutrition, Food and Drug Administration, Washington, DC 20204.
authors.forename: B A
authors.initials: BA
authors.lastname: Myers
authors.forename: J
authors.initials: J
authors.lastname: Hathcock
authors.forename: N
authors.initials: N
authors.lastname: Shiekh
authors.forename: B D
authors.initials: BD
authors.lastname: Roebuck
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003314:Corn Oil / Q000008:administration & dosage; D004435:Eating / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000254:growth & development / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D011230:Precancerous Conditions / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D013025:Glycine max / Q000633:toxicity*; D014361:Trypsin Inhibitors / Q000633:toxicity*
chemical_list: D014361:Trypsin Inhibitors; D003314:Corn Oil