Necrotizing lymphadenitis--a clinico-pathologic study of 36 cases with immunohistochemical analysis.
Thirty-six cases of necrotizing lymphadenitis--including 33 cases of unknown etiology, 1 typhoid lymphadenopathy, and 2 cases of suspicious lupus lymphadenopathy--were clinico-pathologically reviewed and analyzed with immunostaining for s-100 and lysozyme. All cases histologically showed architectural effacement by paracortical lesions composed of nuclear karyorrhexis and mononuclear cell proliferation. Immunohistochemical study revealed proliferation of lysozyme-positive macrophages in the necrotizing areas and an increase in the number of s-100-positive cells in the uninvolved paracortical areas. This observation suggests that necrotizing lymphadenitis may be a common morphologic expression of a T cell-mediated hyperimmune condition induced by diverse etiologies.
Cho
K J
KJ
Department of Pathology, Seoul National University College of Medicine, Korea.
Kim
C W
CW
Park
S H
SH
Lee
S K
SK
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008199:Lymphadenitis / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009113:Muramidase / Q000378:metabolism; D009336:Necrosis; D009418:S100 Proteins / Q000378:metabolism
D009418:S100 Proteins; D009113:Muramidase