title: A comparative study of a progestin-only oral contraceptive versus non-hormonal methods in lactating women in Buenos Aires, Argentina.
abstract: A non-randomized comparative clinical trial of the progestin-only oral contraceptive (POC), Ovrette (75 mcg norgestrel) (Wyeth), versus non-hormonal methods was conducted at two clinics in Buenos Aires, Argentina. The trial was designed to assess the breast-feeding patterns of women choosing progestin-only oral contraception and non-hormonal methods of contraception, and to study the relationship between lactation and the clinical performance of a POC. Five-hundred women were allocated to either the progestin-only pill group (n = 250) or to the non-hormonal group (n = 250) and were followed up monthly for six months after admission. Measurements in mean infant weight, mean infant length, and mean head circumference were similar throughout the follow-up period. Non-hormonal users reported significantly more self-perceived decreases in milk production at the 5th and 6th month follow-up intervals. Acceptance and continued use of the pill were excellent, with only one woman discontinuing because of a pregnancy which was attributed to user failure. The principal side effect reported by women in both groups was intermenstrual bleeding.
authors.affiliation: Family Health International, Research Triangle Park, NC 27709.
authors.forename: A V
authors.initials: AV
authors.lastname: Moggia
authors.forename: G S
authors.initials: GS
authors.lastname: Harris
authors.forename: T R
authors.initials: TR
authors.lastname: Dunson
authors.forename: R
authors.initials: R
authors.lastname: Diaz
authors.forename: M S
authors.initials: MS
authors.lastname: Moggia
authors.forename: M A
authors.initials: MA
authors.lastname: Ferrer
authors.forename: S L
authors.initials: SL
authors.lastname: McMullen
mesh_terms: D000293:Adolescent; D000328:Adult; D001118:Argentina; D001942:Breast Feeding; D003274:Contraceptive Devices, Female; D005260:Female; D005500:Follow-Up Studies; D006128:Growth / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007434:Intrauterine Devices; D007774:Lactation / Q000187:drug effects*; D009644:Norgestrel / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D009644:Norgestrel