[Nuclear DNA analysis of benign skin tumor and carcinoma in site developed from keratinocyte].
To know the variation of DNA contents of seborrheic keratosis, keratoacanthoma, actinic keratosis, and Bowen's disease, cytophotometric assay was used. As the results, following findings were obtained. 1. DNA index of actinic keratosis was higher than those of seborrheic keratosis and keratoacanthoma. 2. DNA index of Bowen's disease was higher than that of seborrheic keratosis. 3. Polyploid cell population (greater than 6C) of keratoacanthoma was higher than that of seborrheic keratosis. 4. Polyploid cell populations (greater than GC) of carcinoma in site (actinic keratosis, Bowen's disease) were higher than that of keratoacanthoma . These date suggested that polyploid cell population and DNA index reflect grade of malignancy of tumor developed from keratinocytes. A clinic keratosis and Bowen's disease revealed almost the same DNA pattern. And the difference of polyploid cell population of keratoacanthoma++ ++ and seborrheic keratosis suggested the difference of the biological activity of them.
Toyoshima
H
H
Department of Dermatology, Nagasaki University School of Medicine.
Hori
M
M
Yoshida
H
H
D000368:Aged; D001913:Bowen's Disease / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D003592:Cytophotometry; D004247:DNA / Q000032:analysis*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000473:pathology*; D007636:Keratoacanthoma / Q000473:pathology; D007642:Keratosis / Q000473:pathology; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
D004247:DNA