The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus.
The chromosomal location of the lambda-like gene cluster, a gene family selectively expressed in human pre-B cells, was analyzed by in situ hybridization with a probe specific for the lambda-like genes. This cluster mapped in the q11.2-q12.3 region of chromosome 22. The use of Burkitt lymphoma and myelogenous leukemia cell lines with translocations in the 22q11 region led to a refinement in the location according to the following order: cen----BCRL2, VpreB, IgV lambda 1----BCRL4, IgV lambda----IgC lambda----BCR----BCRL3, lambda-like----tel. Unlike those of the mouse system, the pre-B-specific genes VpreB and lambda-like do not belong to the same transcriptional unit.
Mattei
M G
MG
Centre de Génétique de la Timone, Hôpital d'Enfants, Marseille, France.
Fumoux
F
F
Roeckel
N
N
Fougereau
M
M
Schiff
C
C
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002051:Burkitt Lymphoma; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000235:genetics*; D007951:Leukemia, Myeloid; D051379:Mice; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic / Q000235:genetics; D014407:Tumor Cells, Cultured
D007146:Immunoglobulin lambda-Chains