Hematological and biochemical effects of parenteral nutrition with medium-chain triglycerides: comparison with long-chain triglycerides.
Twenty-four malnourished patients requiring total parenteral nutrition were randomly assigned to receive a daily infusion of either Lipofundin MCT-LCT [a new lipid preparation containing medium-chain triglycerides (MCTs)], or Lipofundin S [a long-chain triglyceride (LCT) preparation] for 6-28 d. No adverse clinical effects were apparent in patients receiving the new emulsion. Hematological indices were unchanged. Plasma urea concentrations rose less on MCT-LCT than on LCT and the plasma bilirubin concentration was lower. Plasma ketones were higher immediately after the MCT-LCT infusion but not at other times. Triglyceride and fatty acid concentrations were similar. Insulin concentrations were higher on MCT-LCT than on LCT. Daily nitrogen balance values were not significantly different between the two groups. Urinary carnitine excretion fell dramatically on both lipids.
Ball
M J
MJ
Department of Human Nutrition, University of Otago, Dunedin, New Zealand.
D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004338:Drug Combinations; D005227:Fatty Acids / Q000097:blood; D005260:Female; D005990:Glycerol / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007659:Ketones / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D010743:Phospholipids / Q000494:pharmacology*; D013012:Sorbitol / Q000494:pharmacology*; D013024:Soybean Oil / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D004338:Drug Combinations; D005227:Fatty Acids; D007328:Insulin; D007659:Ketones; D010743:Phospholipids; D014280:Triglycerides; C008288:Lipofundin; D013012:Sorbitol; C046535:Lipofundin S; D013024:Soybean Oil; D014508:Urea; D002784:Cholesterol; D009584:Nitrogen; D005990:Glycerol; D001663:Bilirubin