title: Co-induction of jun B and c-fos in a subset of neurons in the spinal cord.
abstract: Noxious stimulation in vivo provokes the transcriptional activation of several genes which are thought to play an important role in the phenomena of stress and pain. In the rat, the expression of the c-fos proto-oncogene is rapidly induced upon noxious stimulation in defined neurons in the dorsal horn of the spinal cord. Interestingly, expression of the prodynorphin gene, which is thought to be involved in the endogenous mechanisms for pain/stress control, also localizes in the same anatomical area. Fos proteins are known to associate in transcriptional complexes with the products of the jun family constituting nuclear factor AP-1. These considerations prompted us to analyse the expression of the jun gene family members c-jun, jun B and jun D in rats subjected to noxious stimulation. We present data indicating that in unstimulated animals the transcripts of the three genes are differentially expressed and abundant within the various laminas of the lumbar spinal cord. Surprisingly, upon stimulation only the jun B transcript is augmented, being co-localized with Fos in a subset of neurons of the medial dorsal horn.
authors.affiliation: Instituto Cajal de Neurociencia, Consejo Superior Investigaciones Científicas, Madrid, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Naranjo
authors.forename: B
authors.initials: B
authors.lastname: Mellström
authors.forename: M
authors.initials: M
authors.lastname: Achaval
authors.forename: J J
authors.initials: JJ
authors.lastname: Lucas
authors.forename: J
authors.initials: J
authors.lastname: Del Rio
authors.forename: P
authors.initials: P
authors.lastname: Sassone-Corsi
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D015870:Gene Expression; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010146:Pain / Q000503:physiopathology; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D012333:RNA, Messenger; D014157:Transcription Factors