Preferential utilization of lactate in neonatal dog brain: in vivo and in vitro proton NMR study.
In vivo proton nuclear magnetic resonance spectroscopy was utilized to determine whether lactate is preferentially utilized as metabolic fuel by the neonatal dog brain. The data showed that during lactate influx, metabolism of lactate could account for most of the fuel needed for oxidative metabolism. The in vivo nuclear magnetic resonance measurements were corroborated by conventional arteriovenous determinations which showed steep decline of arteriovenous difference of glucose and sharp increase in arteriovenous difference of lactate during lactate infusion.
Young
R S
RS
Department of Pediatrics, Yale University School of Medicine, New Haven, Conn.
Petroff
O A
OA
Chen
B
B
Aquila
W J
WJ
Gore
J C
JC
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D005947:Glucose / Q000378:metabolism; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy
D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid; D005947:Glucose