Protective effects of misoprostol on carbon tetrachloride-induced liver damage in the rat.
Effects of misoprostol on histologic and biochemical alterations caused by CCl4 were investigated in the rat. Misoprostol protected against CCl4-induced liver injury. A close correlation occurred between biochemical data and morphological changes. This hepatoprotective effect was observed only when misoprostol was given 30 min before CCl4.
Mihas
A A
AA
Department of Medicine, University of Mississippi Medical Center, Jackson.
Markov
A K
AK
Subramony
C
C
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D016595:Misoprostol; D051381:Rats; D011919:Rats, Inbred Strains
D016595:Misoprostol; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000527:Alprostadil