title: Prolonged hemorrhagic shock does not impair regeneration of plasma coagulant masses in the rabbit.
abstract: METHODS
  Twelve adult male albino rabbits were assigned alternately to normotensive and hypotensive groups to assess the effect of hypovolemic shock on spontaneous correction of dilutional coagulopathy. All animals underwent dilutional exchange transfusion with 200 mL of rabbit RBCs and 5% human albumin. Half the animals were then acutely hemorrhaged and subsequent aliquots of blood removed as needed to maintain the mean arterial pressure at 40 mm Hg.
  
  
  RESULTS
  By 6 hr after production of dilutional coagulopathy, masses and plasma concentrations of fibrinogen and Factor II had increased modestly but significantly, and Factor VII mass and concentration and in vitro coagulation had returned almost to normal; plasma volume was unchanged in the normotensive animals. In the hypovolemic shock animals, where coagulant mass regeneration was as rapid as in the normotensive animals, a doubling of total plasma volume (p less than .01) prevented the concentrations of fibrinogen and Factor II, and hence the coagulation times, from improving.
  
  
  CONCLUSIONS
  Dilutional coagulopathy corrects spontaneously within hours. Normovolemic shock prolongs dilutional coagulopathy not by impairment of factor regeneration but because of further (internal) dilution due to plasma expansion. Rapid correction of dilutional coagulopathy is likely to necessitate cryoprecipitate administration.
authors.affiliation: Department of Critical Care, Hamilton Civic Hospitals, Hamilton General Division, ON, Canada.
authors.forename: J R
authors.initials: JR
authors.lastname: Hewson
authors.forename: D
authors.initials: D
authors.lastname: Prodger
authors.forename: R S
authors.initials: RS
authors.lastname: Roberts
authors.forename: C
authors.initials: C
authors.lastname: Davis
authors.forename: H D
authors.initials: HD
authors.lastname: Fuller
authors.forename: P
authors.initials: P
authors.lastname: Gregor
authors.forename: E J
authors.initials: EJ
authors.lastname: Thomas
authors.forename: B W
authors.initials: BW
authors.lastname: Shragge
authors.forename: J
authors.initials: J
authors.lastname: Russett
authors.forename: P B
authors.initials: PB
authors.lastname: Neame
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology; D001779:Blood Coagulation Factors / Q000378:metabolism*; D005078:Exchange Transfusion, Whole Blood; D005167:Factor VII / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006438:Hemodilution; D008297:Male; D010953:Plasma Volume; D011516:Prothrombin / Q000032:analysis; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000097:blood* / Q000150:complications; D013997:Time Factors
chemical_list: D001779:Blood Coagulation Factors; D005167:Factor VII; D011516:Prothrombin; D005169:Factor VIII; D005340:Fibrinogen