Stoichiometric studies of beta-alanine transporters in rabbit proximal tubule.
The coupling ratio for the transport of beta-alanine and Na+, H+ and Cl- in luminal membrane vesicles isolated from proximal convoluted tubules (pars convoluta) and proximal straight tubules (pars recta) of rabbit kidney was examined. Indirect evidence indicates that 1 H+ and approx. 2 Na+, 1 Cl- (Na(+)-dependent, high-affinity) or 1 Na+ (Na(+)-dependent, low-affinity) are co-transported with beta-alanine in the pars convoluta. In pars recta, the two Na(+)-dependent transporters exhibited the same stoichiometric properties respectively as in pars convoluta.
Jessen
H
H
Institute of Medical Biochemistry, University of Aarhus, Denmark.
Sheikh
M I
MI
D000818:Animals; D001692:Biological Transport; D002712:Chlorides / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007687:Kidney Tubules, Proximal / Q000378:metabolism* / Q000648:ultrastructure; D007700:Kinetics; D011817:Rabbits; D012964:Sodium / Q000378:metabolism; D015091:beta-Alanine / Q000378:metabolism*
D002712:Chlorides; D015091:beta-Alanine; D012964:Sodium