O6-methylguanine-DNA methyltransferase and human cancer chemotherapy.
Two kinds of human tumor cell strains having different activity of O6-methylguanine-DNA methyltransferase (O6-MT) were transplanted into nude mice. Then the mice were injected intraperitoneally with bifunctional alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU). The tumors with low O6-MT activity were quickly suppressed or cured. The result suggests that some tumors, if provisionally determined with low O6-MT activity, might be efficiently cured by treatment with ACNU. This probably opens a new way for human cancer chemotherapy.
Zhang
Y P
YP
Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing, PRC.
Wang
D W
DW
Chen
Y N
YN
Wu
Y
Y
Xu
H Y
HY
Fan
G C
GC
Bai
X B
XB
Wang
X M
XM
Li
J X
JX
Zhu
L
L
D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D029968:Escherichia coli Proteins; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000201:enzymology*; D015376:Nimustine / Q000627:therapeutic use*; D019853:O(6)-Methylguanine-DNA Methyltransferase; D014157:Transcription Factors; D014410:Tumor Stem Cell Assay
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D014157:Transcription Factors; D015376:Nimustine; C045675:Ada protein, E coli; D019853:O(6)-Methylguanine-DNA Methyltransferase