2-Bromolisuride, an ergot derivative, with dopamine antagonistic and serotonin agonistic properties.
The open-field test was used to study the involvement of dopaminergic and serotonergic mechanisms in the effects of 2-bromolisuride on locomotor activity in the rat. 2-Bromolisuride produced a dose-dependent inhibition of spontaneous locomotor activity. This is most likely due to an antagonistic action at postsynaptic dopamine receptors. Low doses of 2-bromolisuride potentiated apomorphine-induced hypermotility. This potentiating effect was not mediated by a blockade of presynaptic dopamine receptors, because it was not prevented by 6-OHDA lesion of the nucleus accumbens. The potentiating effect of 2-bromolisuride was completely blocked by the serotonin antagonists cyproheptadine and ritanserin. It is suggested that 2-bromolisuride possesses dopamine antagonistic and serotonin agonistic properties.
Fink
H
H
Institute of Pharmacology and Toxicology, Charité Humboldt-University, DDR, Berlin.
Morgenstern
R
R
Ott
T
T
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug; D006892:Hydroxydopamines; D008032:Limbic System / Q000187:drug effects / Q000502:physiology; D008090:Lisuride / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects; D013563:Sympathectomy, Chemical
D018492:Dopamine Antagonists; D006892:Hydroxydopamines; D003533:Cyproheptadine; D012701:Serotonin; D016627:Oxidopamine; D008090:Lisuride; C039667:bromerguride; D001058:Apomorphine; D004298:Dopamine