On the tumorigenicity of mitochondrial DNA-depleted avian cells.
We have examined the tumorigenic potential of mitochondrial DNA-depleted (mtDNA-) cells derived from the tumorigenic chicken cell line DU24. The mtDNA- cells were unable to proliferate in the wing web of day-old chicks. Cytoplasmic hybrids resulting from crosses between the mtDNA- whole cells and cytoplasts from enucleated parental cells (mtDNA+) recover both mtDNA and tumorigenicity. These results are in accordance with those obtained in prior experiments where mtDNA was shown to modulate the anchorage-independent phenotype of transformed avian cells.
Zinkewich-Péotti
K
K
Department of Biochemistry, Faculty of Medicine, University of Montreal, Quebec, Canada.
Parent
M
M
Morais
R
R
D000818:Animals; D002455:Cell Division / Q000502:physiology; D002460:Cell Line; D002645:Chickens; D004272:DNA, Mitochondrial / Q000502:physiology*; D006822:Hybrid Cells / Q000502:physiology*; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D010641:Phenotype; D014407:Tumor Cells, Cultured
D004272:DNA, Mitochondrial