title: Trial of flecainide acetate in the management of tinnitus.
abstract: A two-phase trial of flecainide acetate in the management of tinnitus has been carried out in 22 patients with severe long-term tinnitus resistant to other treatments. Although 5 (23%) patients reported some limited benefit the results are not conclusive but suggest that, for such patients, flecainide deserves a place as a drug worth considering as a last resort, with the prospect of it occasionally giving a worthwhile degree of relief.
authors.affiliation: MRC Institute of Hearing Research, Nottingham University, UK.
authors.forename: H M
authors.initials: HM
authors.lastname: Fortnum
authors.forename: R R
authors.initials: RR
authors.lastname: Coles
mesh_terms: D000368:Aged; D004311:Double-Blind Method; D005260:Female; D005424:Flecainide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014012:Tinnitus / Q000188:drug therapy*
chemical_list: D005424:Flecainide