title: Autologous bone marrow transplantation for adult advanced stage lymphoblastic lymphoma in first CR. A study of the NHLCSG.
abstract: Fourty successive adult patients with lymphoblastic lymphoma entered a study of sequential chemotherapy consisting of an intensive LSA-L2-type protocol to induce first complete remission. Twenty-one patients in first CR (median age 24 years, range 15-43), after receiving a conditioning regimen consisting of cyclophosphamide and total body irradiation, underwent autologous bone marrow transplantation. At this time fourteen patients are alive and well 5-72 months post-transplant (median follow-up 58 months) with an actuarial disease free survival of 66%. These early results suggest that high-dose chemoradiotherapy followed by autologous bone marrow transplantation may improve long-term disease free survival in advanced stage adult lymphoblastic lymphoma.
authors.affiliation: Division of Hematology, Ospedale S. Martino, Genoa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Santini
authors.forename: A M
authors.initials: AM
authors.lastname: Congiu
authors.forename: P
authors.initials: P
authors.lastname: Coser
authors.forename: T
authors.initials: T
authors.lastname: Chisesi
authors.forename: A
authors.initials: A
authors.lastname: Porcellini
authors.forename: R
authors.initials: R
authors.lastname: Sertoli
authors.forename: A
authors.initials: A
authors.lastname: Contu
authors.forename: O
authors.initials: O
authors.lastname: Vinante
authors.forename: D
authors.initials: D
authors.lastname: Pierluigi
authors.forename: V
authors.initials: V
authors.lastname: Vitale
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D011446:Prospective Studies; D016019:Survival Analysis