A case of granulomatous hepatitis after intravesical bacillus Calmette-Guerin administration.
A 61-year-old man received intravesical bacillus Calmette-Guerin (BCG) as treatment for superficial bladder carcinoma. High spiking relapsing fevers began 39 days after the initial treatment. A liver biopsy revealed noncaseating granuloma. Deoxyribonucleic acid hybridization of the bone marrow was positive for Mycobacterium tuberculosis complex. Pressure exerted to instill the BCG may have favored dissemination.
Graziano
D A
DA
Jacobs
D
D
Lozano
R G
RG
Buck
R L
RL
D000283:Administration, Intravesical; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000628:therapy; D006099:Granuloma / Q000209:etiology*; D006505:Hepatitis / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000628:therapy
D001500:BCG Vaccine