Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.
We have found that purified human peripheral-blood granulocytes express constitutively significant levels of proto-oncogenes c-jun, jun B and jun D mRNA. Upon functional activation of granulocytes by 4 beta-phorbol 12-myristate 13-acetate (PMA), the levels of c-jun, jun B and jun D transcripts were increased. The three jun genes showed a similar time course in their induction by PMA, maximal mRNA levels being reached after 60 min of induction. These results suggest that expression of c-jun, jun B and jun D genes might be involved in terminal granulocyte differentiation or in regulating granulocyte functionality.
Mollinedo
F
F
Centro de Investigaciones Biológicas, C.S.I.C., Madrid, Spain.
Vaquerizo
M J
MJ
Naranjo
J R
JR
D015152:Blotting, Northern; D004268:DNA-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D016755:Proto-Oncogene Proteins c-jun; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D016755:Proto-Oncogene Proteins c-jun; D012333:RNA, Messenger; D014157:Transcription Factors