[The anti-ischemic action of a perfluorocarbon emulsion (PFCE) on the canine myocardium].
On the 60th minute after inducing the acute ischemia in the canine myocardium by the occlusion of the left anterior descending coronary artery, the animals were intravenously infused with perfluorochemical emulsion (PFCE), its salt composition (SC) or 4% surface-active substance (SAS), proxanol, at a dose of 10 ml/kg. Two hours after infusion, the occlusion was removed (reperfusion). The arterial pO2 was maintained at 120 mm Hg. Analysis of the blood flow, oxygen supply, acid-alkali balance, ECG, as well as creatine phosphokinase activity, measured in the ischemic area, has shown that PFC emulsion is capable of reducing ischemic damage and preventing reperfusion-induced myocardium injury. Thus, the presence of perfluorochemicals in the PFC emulsion is an essential factor in its ischemia-protective effect.
Ladilov
Iu V
IuV
Islamov
B I
BI
Vorob'ev
S I
SI
Ivanitskiĭ
G R
GR
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D003327:Coronary Disease / Q000378:metabolism / Q000517:prevention & control*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004655:Emulsions; D005260:Female; D005466:Fluorocarbons / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D013997:Time Factors
D004655:Emulsions; D005466:Fluorocarbons; D002245:Carbon Dioxide; D010100:Oxygen
Protivoishemicheskoe deĭstvie perftoruglerodnoĭ émul'sii (PFUE) na miokarda sobak.