Differential effects of angiotensin II and eledoisin on monoamine oxidase A and B activities in rat brain.
Intracerebroventricular injections of angiotensin II caused 108, 62, and 54% increases in monoamine oxidase A activities in rat hippocampus, hypothalamus, and striatum, respectively. These activatory effects were abolished by simultaneous injections of eledoisin. No significant changes of monoamine oxidase B activities were found under the same experimental conditions. Neither angiotensin II nor elodoisin changed substrate/inhibitor affinities of both isoenzymes. These data indicate that angiotensin II and tachykinin transmitter systems may exert opposite, long-term regulatory effects on monoaminergic neurons in rat brain.
Tomaszewicz
M
M
Department of Clinical Biochemistry, Medical Academy, Gdansk, Poland.
Micossi
L G
LG
Bielarczyk
H
H
Luszawska
D
D
Santarelli
I
I
Szutowicz
A
A
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001596:Benzylamines / Q000037:antagonists & inhibitors; D001921:Brain / Q000201:enzymology* / Q000378:metabolism; D003010:Clorgyline / Q000494:pharmacology; D004600:Eledoisin / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007552:Isotonic Solutions / Q000494:pharmacology; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009655:Octopamine / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D012642:Selegiline / Q000494:pharmacology; D014018:Tissue Distribution
D001596:Benzylamines; D007552:Isotonic Solutions; C037692:Tyrode's solution; D000804:Angiotensin II; D009655:Octopamine; D012642:Selegiline; D004600:Eledoisin; C030796:benzylamine; D008995:Monoamine Oxidase; D003010:Clorgyline