[Occurrence of complement defects in meningococcal disease: who should be examined?].
Congenital complement deficiency states occur very rarely. These deficiencies are associated with a high risk of meningococcal disease (MD). We suggest that the following groups of individuals with MD are examined for complement deficiencies: 1. Individuals belonging to families, in which more than one case of MD has occurred with an interval exceeding one month. 2. Individuals infected with the low-virulent meningococcal serogroups W-135, 29E, X, Y, Z. 3. Individuals with recurrent MD. Since properdin deficiency probably is the most common deficiency associated with MD it is important that the screening includes the alternative complement pathway.
Nielsen
H E
HE
Statens Seruminstitut, København.
Magnussen
P
P
Lind
I
I
D003165:Complement System Proteins / Q000172:deficiency* / Q000235:genetics; D006801:Humans; D008585:Meningitis, Meningococcal / Q000235:genetics / Q000276:immunology*; D009345:Neisseria meningitidis / Q000145:classification / Q000276:immunology; D012008:Recurrence; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D012703:Serotyping
D003165:Complement System Proteins
Forekomsten af komplementdefekter ved meningokoksygdom: Hvem skal undersøges?