Principles of selective inactivation of viral genome. VI. Inactivation of the infectivity of the influenza virus by the action of beta-propiolactone.
The kinetics of inactivation of the infectivity of the influenza virus by beta-propiolactone have been studied. Rate constants have been determined for inactivation of the A/Leningrad/385 (H3N2) and B/Leningrad/489/80 influenza virus under the action of beta-propiolactone on a virus-containing allantoic fluid and on a purified viral suspension. The data obtained allow calculation of the time required for inactivation of the influenza virus infectivity to a given extent in virus-containing solutions at any initial concentration of beta-propiolactone.
Budowsky
E I
EI
N.D. Zelinsky Institute of Organic Chemistry, USSR Academy of Sciences, Moscow.
Friedman
E A
EA
Zheleznova
N V
NV
Noskov
F S
FS
D000818:Animals; D002642:Chick Embryo; D005814:Genes, Viral / Q000187:drug effects; D009980:Influenza A virus / Q000187:drug effects; D009981:Influenza B virus / Q000187:drug effects; D007252:Influenza Vaccines / Q000302:isolation & purification; D007700:Kinetics; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D011420:Propiolactone / Q000494:pharmacology*; D015164:Vaccines, Inactivated / Q000302:isolation & purification
D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D011420:Propiolactone