Potentiation of diabetic glomerulopathy in uninephrectomized rats subchronically exposed to cadmium.
The renal effects of diabetes mellitus and cadmium (Cd), separately or in combination, were investigated in unilaterally nephrectomized female Sprague-Dawley rats. Diabetes was induced by injection of streptozotocin and Cd was administered in drinking water at a concentration of 100 p.p.m. for 2.5 months. Cd did not affect the reduction in glomerular filtration rate or the rise in beta 2-microglobulinuria caused by diabetes. By contrast, the effect of diabetes on the urinary excretion of albumin, transferrin or IgG was greatly enhanced by concomitant exposure to Cd. This interaction occurred at Cd levels in the renal cortex which are very similar to those found in the general population of industrialized countries. These observations, in agreement with the results of a recent epidemiological study, suggest that Cd polluting the environment might potentiate the development of diabetic nephropathy.
Bernard
A
A
Unit of Industrial Toxicology and Occupational Medicine, Catholic University of Louvain, Brussels, Belgium.
Schadeck
C
C
Cardenas
A
A
Buchet
J P
JP
Lauwerys
R
R
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002104:Cadmium / Q000493:pharmacokinetics / Q000633:toxicity*; D019256:Cadmium Chloride; D002105:Cadmium Poisoning / Q000150:complications / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000150:complications / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013997:Time Factors; D014018:Tissue Distribution; D001613:beta 2-Microglobulin / Q000652:urine
D001786:Blood Glucose; D001613:beta 2-Microglobulin; D002104:Cadmium; D019256:Cadmium Chloride