Response of osteosarcoma and Ewing sarcoma to chemotherapy: imaging evaluation.
The importance of diagnostic imaging in evaluating therapeutic response of bone sarcomas has increased with the use of chemotherapy administered before radiation therapy or surgery. The information provided by imaging studies is used to estimate prognosis; modify preoperative chemotherapy; and plan radiation therapy, surgery, and postoperative chemotherapy. This review examines the value and illustrates some pitfalls of traditional imaging methods, including conventional radiography, angiography, CT, and radionuclide scintigraphy, and discusses recent efforts to monitor therapy by using MR imaging and MR spectroscopy.
Fletcher
B D
BD
Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN 38101-0318.
D000792:Angiography; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011877:Radionuclide Imaging; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed