The fate of monochlorobenzanilides in the rat.
The fate of the three isomeric benzoic acid-substituted monochlorobenzanilides has been studied in the rat after their oral administration. The excretory profile of all three isomers was similar with over half of the dose being excreted in the 0-24 hour urine and between 83-87% being recovered during the three days following administration. The most prominent route of metabolism was that of 4'-hydroxylation on the unsubstituted aniline moiety followed by glucuronic acid conjugation.
Mitchell
S C
SC
Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, London, England.
O'Gorman
J
J
Waring
R H
RH
D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D002722:Chlorobenzenes / Q000493:pharmacokinetics*; D002855:Chromatography, Thin Layer; D005243:Feces / Q000737:chemistry; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D002722:Chlorobenzenes; C031294:chlorobenzene