Efficacy of fixed minidose warfarin prophylaxis in total hip replacement.
OBJECTIVE
To determine whether a small fixed perioperative dose of warfarin would prevent deep vein thrombosis after total hip replacement.


METHODS
Prospective, randomised, double blind placebo controlled trial.


METHODS
Winford Orthopaedic Hospital, Bristol.


METHODS
148 patients having primary total hip replacement.


METHODS
Warfarin 1 mg given daily for one week before and three weeks after surgery.


METHODS
Deep vein thrombosis diagnosed by the iodine-125 labelled fibrinogen uptake method.


RESULTS
Deep vein thrombosis occurred in 25 (34%) of the patients given warfarin and 19 (26%) of the controls (difference 8%; 95% confidence interval -6.8% to 22.8%).


CONCLUSIONS
Fixed minidose warfarin does not prevent deep vein thrombosis after total hip replacement.
Fordyce
M J
MJ
Winford Orthopaedic Hospital, Bristol.
Baker
A S
AS
Staddon
G E
GE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D005260:Female; D005268:Femoral Vein / Q000000981:diagnostic imaging; D006622:Hip Prosthesis; D006801:Humans; D007432:Intraoperative Period; D007457:Iodine Radioisotopes; D008297:Male; D011152:Popliteal Vein / Q000000981:diagnostic imaging; D011183:Postoperative Complications / Q000517:prevention & control*; D011877:Radionuclide Imaging; D013924:Thrombophlebitis / Q000517:prevention & control; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000517:prevention & control*; D014859:Warfarin / Q000008:administration & dosage*
D007457:Iodine Radioisotopes; D014859:Warfarin