The influence of inadvertent intranasal buserelin administration in early pregnancy.
Buserelin was inadvertently administered during 13 early pregnancies in 12 women with long-standing infertility, who had started the GnRH-agonist for gonadotrophin desensitization prior to ovarian stimulation for IVF. Six women delivered a healthy child and one pregnancy continues uneventfully. Three patients aborted before the sixth week and three women with tubal disease had an ectopic pregnancy. Corpus luteum function was normal in 11 of the 13 pregnancies. Although no evidence of embryotoxic effects of buserelin was observed, barrier contraceptive methods should be advised during the first days of its administration.
Smitz
J
J
Centre for Reproductive Medicine, Academic Hospital, Vrije Universiteit Brussel, Belgium.
Camus
M
M
Devroey
P
P
Bollen
N
N
Tournaye
H
H
Van Steirteghem
A C
AC
D000281:Administration, Intranasal; D000328:Adult; D002064:Buserelin / Q000008:administration & dosage / Q000009:adverse effects*; D003338:Corpus Luteum / Q000187:drug effects; D005260:Female; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First / Q000187:drug effects*
D002064:Buserelin