title: [The role of the ADP/ATP-antiporter in the inhibition of nonspecific permeability of the inner mitochondrial membrane by cyclosporin A].
abstract: The effect of the conformational state of the ADP/ATP-antiporter on the efficiency of inhibition by cyclosporine A of the Ca(2+)-induced increase of nonspecific permeability of the inner mitochondrial membrane was under study. It was found that the ADP/ATP-antiporter inhibitor carboxyatractyloside is able to reverse the cyclosporine A-induced inhibition of this nonspecific permeability. The effect of carbocyatractyloside is manifested only in mitochondria depleted of adenine nucleotides. The bifunctional SH-reagent phenylarsine oxide is also able to reverse the cyclosporine A effect. The data obtained testify to the fact that inhibition by cyclosporine A of nonspecific permeability is due to its effect on the conformational state of the ADP/ATP-antiporter.
authors.forename: S A
authors.initials: SA
authors.lastname: Novgorodov
authors.forename: T I
authors.initials: TI
authors.lastname: Gudz'
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Kushnareva
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Kudriashov
mesh_terms: D001152:Arsenicals / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D003524:Cyclosporins / Q000494:pharmacology*; D005033:Ethylmaleimide / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects / Q000502:physiology; D008634:Mersalyl / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects*; D000226:Mitochondrial ADP, ATP Translocases / Q000502:physiology*; D010539:Permeability / Q000187:drug effects
chemical_list: D001152:Arsenicals; D003524:Cyclosporins; C029341:oxophenylarsine; D008634:Mersalyl; D000226:Mitochondrial ADP, ATP Translocases; D005033:Ethylmaleimide; D002118:Calcium
vernacular_title: Rol' ADP/ATP-antiportera v podavlenii tsiklosporinom A nespetsificheskoĭ pronitsaemosti vnutrenneĭ membrany mitokhondrii.