Role of gamma interferon in Toxoplasma gondii infection.
Toxoplasma gondii has emerged as an important pathogen in the ever increasing numbers of patients with disorders of the immune system. Better understanding of the mechanisms of resistance of the host against this protozoan is important for development of safe, effective alternative treatment regimens for toxoplasmosis. Gamma interferon is the cytokine that plays a central role in protection against Toxoplasma gondii. The purpose of this review is to highlight the current knowledge of the role of gamma interferon in Toxoplasma gondii infection.
Subauste
C S
CS
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, California 94301.
Remington
J S
JS
D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D004359:Drug Therapy, Combination; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000627:therapeutic use; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism / Q000469:parasitology; D013601:T-Lymphocytes / Q000378:metabolism*; D014122:Toxoplasma; D014123:Toxoplasmosis / Q000401:mortality / Q000469:parasitology / Q000517:prevention & control*
D000911:Antibodies, Monoclonal; D007371:Interferon-gamma