Shift of excretory-secretory immunogens of Trypanosoma cruzi during human Chagas' disease.
We studied secreted-excreted immunogens in human patients infected with Trypanosoma cruzi. A pair of 45- to 55-kDa antigens and a family of shed acute-phase antigens characterized the acute phase, while antibodies against a 160- to 170-kDa immunogen appeared at the chronic phase of the disease.
Jazín
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EE
Instituto de Investigaciones Bioquímicas, Luis F. Leloir, Fundación Campomar, Buenos Aires, Argentina.
Luquetti
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AO
Rassi
A
A
Frasch
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AC
D000208:Acute Disease; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis*; D000953:Antigens, Protozoan / Q000032:analysis*; D014355:Chagas Disease / Q000188:drug therapy / Q000276:immunology*; D002908:Chronic Disease; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D015151:Immunoblotting; D009593:Nitroimidazoles / Q000627:therapeutic use; D011817:Rabbits; D014344:Trypanocidal Agents / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000276:immunology*
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole