[The experimental and clinical antitumor action of the interferon inducer larifan].
The paper presents the results of experimental and clinical studies on the antitumor effect of larifan. A statistically significant inhibition of growth of some continuous mouse tumors by larifan in a dose of 2.5 mg/kg given for 5-6 days and by a combination of larifan with an immunomodulator, inosiplex, tested on hepatoma XXIIa which has a rather low sensitivity to larifan. The antitumor effect of larifan may be due to interferon production and immunomodulating effect. Treatment with 0.05% larifan ointment of patients with cervical dysplasia of moderate degree resulted in a significant increase of previously diminished production of alpha-interferon after 10-14 vaginal tampons and clinical cure in 88% of cases. A course of 8-10-day larifan monotherapy given before radial therapy resulted in a considerable improvement in patients with cervical cancer of II-III stages, and subsequently, for 1 1/2-month combined radial therapy, no significant changes in production of alpha-IF were observed. At the same time, in patients with cervical cancer treated by radial therapy alone a significant decrease of alpha-IF production by blood mononuclears was observed by the end of therapy.
Gasparian
M G
MG
Dzhagatspanian
N G
NG
Gevorkian
R A
RA
Kamalian
L A
LA
D000282:Administration, Intravaginal; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D004354:Drug Screening Assays, Antitumor; D005260:Female; D007369:Interferon Inducers / Q000008:administration & dosage / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000097:blood; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology; D009930:Organic Chemicals; D002578:Uterine Cervical Dysplasia / Q000188:drug therapy / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000276:immunology
D000970:Antineoplastic Agents; D007369:Interferon Inducers; D009930:Organic Chemicals; C066530:larifan; D007371:Interferon-gamma
Protivoopukholevoe deĭstvie induktora interferona larifana v éksperimente i klinike.