title: The human aldose reductase gene maps to chromosome region 7q35.
abstract: The human aldose reductase (AR) gene has been mapped to chromosome 7 using the polymerase chain reaction to specifically amplify the human AR sequence in hamster/human hybrid DNA and also in mouse/human monochromosome hybrids. The assignment to chromosome 7 was confirmed by in situ hybridisation to human metaphase chromosomes using a novel, rapid hybridisation, method giving a regional localisation at 7q35.
authors.affiliation: Biotechnology Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, UK.
authors.forename: A
authors.initials: A
authors.lastname: Graham
authors.forename: P
authors.initials: P
authors.lastname: Heath
authors.forename: J E
authors.initials: JE
authors.lastname: Morten
authors.forename: A F
authors.initials: AF
authors.lastname: Markham
mesh_terms: D000449:Aldehyde Reductase / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D003360:Cosmids; D006224:Cricetinae; D004247:DNA; D006801:Humans; D006822:Hybrid Cells; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction
chemical_list: D004247:DNA; D000449:Aldehyde Reductase