title: Tissue-plasminogen activator for pulmonary embolism resulting in shock: two case reports and discussion of the literature.
abstract: Two patients with significant relative contraindications to fibrinolysis, and with refractory shock caused by acute pulmonary embolism, who were successfully treated with recombinant tissue-type plasminogen activator (rt-PA) are reported. The role of rt-PA in the management of pulmonary embolism is discussed, and pertinent literature is reviewed.
authors.affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
authors.forename: J P
authors.initials: JP
authors.lastname: Mitchell
authors.forename: E P
authors.initials: EP
authors.lastname: Trulock
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000150:complications* / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012769:Shock / Q000209:etiology*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator