title: Pulmonary manifestations of HIV infection in children.
abstract: We retrospectively reviewed the spectrum, course, and outcome of pulmonary diseases in 66 children with AIDS, hospitalized between 1982 and 1988, prior to the use of zidovudine. Fifty-two of the 66 (79%) patients developed pulmonary problems. In fifty-two percent of all patients, a pulmonary problem was the first symptom of HIV infection. The most common respiratory illness requiring hospitalization was an episode of respiratory distress with normal PaO2 and unchanged X-ray with a 9.7 +/- 6.8 days mean duration of hospitalization. Bacterial pneumonia, Pneumocystis carinii pneumonia (PCP) and pulmonary lymphoid hyperplasia/lymphoid interstitial pneumonia occurred in 30%, 32% and 22% of the patients, respectively. Bacterial pneumonia and PCP were associated with a high mortality rate. Sixty-eight percent of the patients died within 24 months of the onset of pulmonary disease. In 50% of the children, pulmonary disease was a primary cause of death. The results of this study can be useful in developing prospective studies for the prevention and treatment of pulmonary complications of HIV infection.
authors.affiliation: Mount Sinai Medical Center, Pediatric Pulmonary Division, New York, NY 10029.
authors.forename: J
authors.initials: J
authors.lastname: Marolda
authors.forename: B
authors.initials: B
authors.lastname: Pace
authors.forename: R J
authors.initials: RJ
authors.lastname: Bonforte
authors.forename: N M
authors.initials: NM
authors.lastname: Kotin
authors.forename: J
authors.initials: J
authors.lastname: Rabinowitz
authors.forename: M
authors.initials: M
authors.lastname: Kattan
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000293:Adolescent; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D009894:Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D011014:Pneumonia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D012189:Retrospective Studies