[Influence of beclomethasone dipropionate on rabbit's nasal mucosa, adrenal and frog oral mucociliary activities].
The histology and surface ultrastructures of the nasal mucosa and adrenal after intranasal beclomethasone dipropionate (BDP) 400mg/day for 5 weeks were observed with light and scanning electron microscopes in rabbits. Besides, the ciliary activities in vitro and mucociliary transportation function in frog oral mucosa after administrating BDP were studied. The results showed that intranasal BDP did not produce significant lesions of the nasal mucosa and atrophy of the adrenal in rabbits and BDP did not reduce oral mucociliary activities in frog. It suggests that intranasal BDP therapy is safe.
Li
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Y
Third Clinical College of Zhongshan University of Medical Sciences, Guangzhou.
D000281:Administration, Intranasal; D000302:Adrenal Cortex / Q000033:anatomy & histology / Q000187:drug effects*; D000818:Animals; D001001:Anura; D001507:Beclomethasone / Q000008:administration & dosage / Q000494:pharmacology*; D009079:Mucociliary Clearance / Q000187:drug effects*; D009297:Nasal Mucosa / Q000187:drug effects* / Q000648:ultrastructure; D011817:Rabbits
D001507:Beclomethasone