title: Biologic rationale of combined radiotherapy and chemotherapy.
abstract: This article presents a brief review of the mechanisms by which chemotherapy can be combined with radiotherapy to improve the therapeutic ratio, the possible mechanisms of interaction between chemotherapy and radiotherapy, the various factors that may influence their combined effects, and future perspectives in this area of clinical and laboratory research.
authors.affiliation: Department of Radiation Oncology, University of California, San Francisco.
authors.forename: K K
authors.initials: KK
authors.lastname: Fu
authors.forename: T L
authors.initials: TL
authors.lastname: Phillips
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans