A case of myelodysplastic syndrome with abnormal megakaryocytes and ins(8;3)(q24;q21q26).
We report a 56-year-old male patient with refractory anemia with excess of blasts in transformation (RAEB-T) who had an ins(8;3)(q24;q21q26) as the sole chromosome abnormality in bone marrow (BM) cells. The findings of disturbed thrombocytopoiesis with numerous micromegakaryocytes suggest that it could be a variant of the classic ins(3;3)(q26;q21q26) described in hematologic malignancies with abnormal thrombopoiesis.
Bachy-Delhomme
M
M
Department of Hematology-Cytogenetics, Centre Hôpitalier, Saint Priest en Juarez, France.
Bertheas
M F
MF
Jaubert
J
J
Calmard
P
P
Vasselon
C
C
Reynaud
J
J
Brizard
C P
CP
D001853:Bone Marrow / Q000473:pathology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology