title: 4-Hydroxy-2-cyclopentenone: an anti-Pseudomonas and cytotoxic component from Passiflora tetrandra.
abstract: 4-Hydroxy-2-cyclopentenone is responsible for the anti-bacterial activity of an extract of leaves from Passiflora tetrandra with minimum inhibitory doses (MID) of ca. 10 micrograms/disk against Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa. 4-Hydroxy-2-cyclopentenone is also cytotoxic to P388 murine leukemia cells (IC50 of less than 1 microgram/ml).
authors.affiliation: Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
authors.forename: N B
authors.initials: NB
authors.lastname: Perry
authors.forename: G D
authors.initials: GD
authors.lastname: Albertson
authors.forename: J W
authors.initials: JW
authors.lastname: Blunt
authors.forename: A L
authors.initials: AL
authors.lastname: Cole
authors.forename: M H
authors.initials: MH
authors.lastname: Munro
authors.forename: J R
authors.initials: JR
authors.lastname: Walker
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D003517:Cyclopentanes / Q000302:isolation & purification / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D003517:Cyclopentanes; C070238:4-hydroxy-2-cyclopentenone