[Analysis of the regulation of IgG production to Cryptomeria japonica pollen antigen].
Genetic control of the immune response to Cryptomeria japonica pollen antigen (CPAg) in humans was analyzed using 72 unrelated healthy adults. The 72 were classified into a low responder group and a high responder group by using purified CPAg. Significant associations were found between IgG low responsiveness to purified CPAg and possession of HLA-DQw3. Relative risks for the two groups were 4.80. Peripheral blood lymphocytes from low responders revealed a specific IgG response to CPAg when the CD8+ T cell fraction was depleted. Thereby, low response due to the presence of CPAg-specific CD8+ suppressor T cells was suggested.
Honda
K
K
Department of Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health.
Makishima
K
K
Sasazuki
T
T
D000328:Adult; D000917:Antibody Formation / Q000235:genetics*; D000941:Antigens / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D016827:CD8 Antigens; D006683:HLA-DQ Antigens / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007564:Japan; D011058:Pollen / Q000276:immunology*; D014197:Trees
D000941:Antigens; D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D006683:HLA-DQ Antigens; D007074:Immunoglobulin G