title: Isolated angiitis of the central nervous system: involvement of penetrating vessels at the base of the brain.
abstract: Isolated angiitis of the central nervous system (IAC) was diagnosed in a 40-year-old Caucasian male by histological examination of a leptomeningeal biopsy specimen, and the exclusion of systemic inflammatory or infective disease. Therapy with prednisone 30 mg/day and cyclophosphamide 100 mg/day resulted in clinical and radiological improvement, which have been maintained for an 8-month follow-up period. Magnetic resonance imaging (MRI) showed lesions implicating involvement of specific penetrating vessels at the base of the brain, an unusual complication of IAC, and allowed an accurate MRI-clinical correlation.
authors.affiliation: Department of Neurology, H.F. Verwoerd Hospital, University of Pretoria, Republic of South Africa.
authors.forename: P
authors.initials: P
authors.lastname: Stübgen
authors.forename: B P
authors.initials: BP
authors.lastname: Lotz
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply*; D002536:Cerebral Arteries; D003342:Corpus Striatum / Q000098:blood supply / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D013788:Thalamus / Q000098:blood supply / Q000473:pathology; D014657:Vasculitis / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D003520:Cyclophosphamide; D011241:Prednisone