[Complex assessment of the production of 3 variants of interleukin-1 by human peripheral blood monocytes].
In vitro production of intracellular, membrane-associated and secreted interleukin-1 was investigated by peripheral blood monocytes from healthy donors. Activity of three IL-1 variants was assayed by the proliferation of responsive C3H/HeJ mouse thymocytes. Complex evaluation of IL-1 pools production by human PBM would provide a key to a better understanding of various diseases pathogenesis.
Stonane
E Iu
EIu
Pavliuk
A S
AS
Koval'chuk
L V
LV
Petrov
R V
RV
D000818:Animals; D002478:Cells, Cultured; D003470:Culture Media; D004926:Escherichia coli; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000145:classification; D008070:Lipopolysaccharides; D008213:Lymphocyte Activation; D051379:Mice; D008809:Mice, Inbred C3H; D009000:Monocytes / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology
D003470:Culture Media; D007375:Interleukin-1; D008070:Lipopolysaccharides; D007213:Indomethacin
Kompleksnaia otsenka produktsii 3 variantov interleĭkina-1 monotsitami perifericheskoĭ krovi cheloveka.