The influence of steroid therapy and recombinant human erythropoietin on the growth of children with renal disease.
Long-term steroid therapy has a depressant effect on hypothalamo-pituitary pulsatile secretion of growth hormone (GH), and this results in an attenuated pubertal growth spurt. Oxandrolone and recombinant human GH improve growth rates in children taking long-term steroid therapy for renal disease, but there are potential side effects. Treatment with recombinant human erythropoietin improved the growth of three prepubertal, but not three pubertal haemodialysis patients.
Rees
L
L
Department of Paediatrics, United Medical School, Guy's Hospital, London, UK.
Rigden
S P
SP
Chantler
C
C
D000293:Adolescent; D000740:Anemia / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D004921:Erythropoietin / Q000627:therapeutic use*; D006128:Growth / Q000187:drug effects*; D006130:Growth Disorders / Q000188:drug therapy* / Q000503:physiopathology; D013006:Growth Hormone / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D016030:Kidney Transplantation; D010074:Oxandrolone / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D006435:Renal Dialysis; D013256:Steroids / Q000009:adverse effects*
D011994:Recombinant Proteins; D013256:Steroids; D004921:Erythropoietin; D010074:Oxandrolone; D013006:Growth Hormone