[Modulation of the growth of cultured human mammary cancer cells MCF-7 by C19 steroids].
We describe the effect of 12 C19-steroids on human breast cancer hormono-dependent cell growth. 5-Androstene-3 beta, 17 beta diol and 5 alpha-androstane-3 beta, 17 beta diol are the most mitogenic Dehydroepiandrosterone, 5 beta-androstane-3 beta, 17 beta diol and the two 5-androstane-3 alpha, 17 beta diol are less mitogenic. 5 alpha-Dihydrotestosterone and testosterone have no effect at physiologic doses, but can modulate MCF-7 growth at pharmacologic concentrations. Androsterone and etiocholanolone have no effect, whereas androstenedione inhibits MCF-7 cell growth.
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Laboratoire de biochimie, faculté de pharmacie, Limoges, France.
D000731:Androstanes / Q000097:blood / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000097:blood / Q000473:pathology*; D004958:Estradiol; D005260:Female; D006801:Humans; D008593:Menopause / Q000097:blood; D009376:Neoplasms, Hormone-Dependent / Q000097:blood / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000731:Androstanes; D004958:Estradiol
Modulation de la croissance de cellules cancéreuses mammaires humaines MCF-7 en culture par des stéroïdes-C19.