4-Hydroxy-2-cyclopentenone: an anti-Pseudomonas and cytotoxic component from Passiflora tetrandra.
4-Hydroxy-2-cyclopentenone is responsible for the anti-bacterial activity of an extract of leaves from Passiflora tetrandra with minimum inhibitory doses (MID) of ca. 10 micrograms/disk against Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa. 4-Hydroxy-2-cyclopentenone is also cytotoxic to P388 murine leukemia cells (IC50 of less than 1 microgram/ml).
Perry
N B
NB
Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
Albertson
G D
GD
Blunt
J W
JW
Cole
A L
AL
Munro
M H
MH
Walker
J R
JR
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D003517:Cyclopentanes / Q000302:isolation & purification / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D003517:Cyclopentanes; C070238:4-hydroxy-2-cyclopentenone