title: Immunological abnormalities in pediatric AIDS.
abstract: HIV infection of a fetus from an infected mother has severe immunological implications because it destroys still immature immune system. The abnormalities observed are precocious in the infants. When the infection occurs in perinatal period, clinical and immunological manifestations can present themselves at the age of 2-5 years. Two patterns of HIV infection can be distinguished. Humoral immunodeficiency is present in a high proportion of patients and leads to repeated bacterial infections and progression of the disease. Immunoglobulin substitution therapy improves clinical manifestations and can help to avoid viral replication.
authors.affiliation: Pediatric Hospital R.S. Valle Hebron, Barcelona, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Español
authors.forename: X
authors.initials: X
authors.lastname: Garcia
authors.forename: I
authors.initials: I
authors.lastname: Caragol
authors.forename: S
authors.initials: S
authors.lastname: Sauleda
authors.forename: C
authors.initials: C
authors.lastname: Muntane
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D000361:Agammaglobulinemia / Q000209:etiology*; D000917:Antibody Formation; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens; D002675:Child, Preschool; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology*; D017098:IgA Deficiency; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D007375:Interleukin-1 / Q000032:analysis; D007376:Interleukin-2 / Q000032:analysis
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D007074:Immunoglobulin G; D007375:Interleukin-1; D007376:Interleukin-2