Large vessel occlusion, cerebral infarction and thrombocytopenia in the "primary" antiphospholipid syndrome. Response to anticoagulation.
A 65-year-old white female without lupus developed concurrent thrombocytopenia and disturbed arterial circulation to the brain and lower leg (a minor stroke and lower leg gangrene, necessitating amputation). Laboratory studies disclosed high levels of anticardiolipin antibodies. Anticoagulant treatment restored circulation in the remaining leg and also normalized platelet levels. This case emphasizes the importance of searching for anticardiolipin antibodies in unexplained thrombotic events.
Locht
H
H
Department of Medicine, University Hospital, Linköping, Sweden.
Lindström
F D
FD
Herder
A
A
D000368:Aged; D000906:Antibodies / Q000032:analysis*; D000925:Anticoagulants / Q000627:therapeutic use*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology; D002308:Cardiolipins / Q000276:immunology; D002544:Cerebral Infarction / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005734:Gangrene / Q000209:etiology; D006801:Humans; D007866:Leg / Q000098:blood supply*; D016682:Lupus Coagulation Inhibitor; D010743:Phospholipids / Q000276:immunology*; D013577:Syndrome; D013921:Thrombocytopenia / Q000150:complications*; D013927:Thrombosis / Q000150:complications; D014652:Vascular Diseases / Q000150:complications* / Q000188:drug therapy
D000906:Antibodies; D000925:Anticoagulants; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor; D010743:Phospholipids