del(15)(q11q15) associated with transformation of chronic myelomonocytic leukemia.
Nonrandom cytogenetic abnormalities have been described in a variety of human malignancies including myelodysplastic syndromes (MDS). Acquisition of new chromosomal abnormalities may herald onset of a more aggressive disease. We report a patient with chronic myelomonocytic leukemia (CMMoL) who initially had a normal karyotype, but in whom the clonal interstitial deletion of chromosome 15 (q11-q15) was coincident with development of acute myeloid leukemia (AML) one year later. To date, this chromosomal change has not been reported in CMMoL, AML, or any other human malignancy.
Provan
A
A
Department of Haematology, Royal South Hants Hospital, Southampton, England.
Majer
R V
RV
Herbert
A
A
Smith
A G
AG
D000368:Aged; D001803:Blood Transfusion; D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15; D006801:Humans; D006918:Hydroxyurea; D007621:Karyotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008297:Male; D008677:Metaphase; D014170:Transformation, Genetic
D006918:Hydroxyurea