title: Comparison of the combined effects of atropine and neostigmine with atropine and edrophonium on the lower oesophageal sphincter.
abstract: In two groups (n = 11) of healthy patients, we have measured gastric, lower oesophageal and barrier pressures before and after antagonism of neuromuscular block during anaesthesia with nitrous oxide and isoflurane. In one group, atropine 1.2 mg and neostigmine 2.5 mg were given and in the second group atropine 0.6 mg with edrophonium 1 mg/kg. One minute after administration of the reversal agents, there was a significantly greater reduction in barrier pressures in the neostigmine and atropine group than in the edrophonium and atropine group, but subsequently, there was no significant difference between the two groups. We conclude that there is no clinical difference between the two reversal mixtures in terms of the risk of regurgitation in the immediate period after reversal.
authors.affiliation: University Department of Anaesthesia, Leicester Royal Infirmary.
authors.forename: S A
authors.initials: SA
authors.lastname: Heijke
authors.forename: G
authors.initials: G
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Key
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D001285:Atropine / Q000494:pharmacology*; D004491:Edrophonium / Q000494:pharmacology*; D004943:Esophagogastric Junction / Q000187:drug effects*; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D009388:Neostigmine / Q000494:pharmacology*; D009466:Neuromuscular Blocking Agents / Q000037:antagonists & inhibitors; D011183:Postoperative Complications / Q000209:etiology; D011312:Pressure; D011897:Random Allocation; D012307:Risk Factors
chemical_list: D009466:Neuromuscular Blocking Agents; D009388:Neostigmine; D004491:Edrophonium; D001285:Atropine