title: Acute cyclosporin overdose. A review of present clinical experience.
abstract: Although cyclosporin is widely used in transplant patients, experience regarding the consequences of an overdose is limited. This article summarises the data available on 27 patients with oral (n = 20) or parenteral (n = 7) overdosage of cyclosporin. The available clinical data are consistent with predictions derived from animal toxicological studies, suggesting a low acute toxicity of the drug in humans. Acute oral overdoses result in minimal clinical manifestations and/or mild degrees of renal dysfunction, primarily in patients with previously impaired kidney function. Acute parenteral overdoses may have more serious consequences, premature neonates being at particular risk of developing life-threatening reactions. Determinations of blood concentrations of cyclosporin are of limited use in the management of patients with acute overdose. Guidelines are suggested for the management of such patients.
authors.affiliation: Sandoz Pharma Ltd, Drug Monitoring Centre, Basel, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Arellano
authors.forename: C
authors.initials: C
authors.lastname: Monka
authors.forename: P F
authors.initials: PF
authors.lastname: Krupp
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003524:Cyclosporins / Q000506:poisoning*; D062787:Drug Overdose / Q000628:therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged
chemical_list: D003524:Cyclosporins