title: Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids.
abstract: C22:1 omega 5-anacardic acid was found to be a good inhibitor of both potato lipoxygenase and ovine prostaglandin endoperoxide synthase with approximate IC50's of 6 and 27 microM, respectively. Very similar inhibition was seen with the crude exudate, rich in omega 5-anacardic acids, from glandular trichomes of an arthropod-resistant strain of geranium, Pelargonium xhortorum. The saturated anacardic acid (C22:0 sat), abundant in the trichome exudate of susceptible strains, was nearly as inhibitory toward both prostaglandin endoperoxide synthase and lipoxygenase as the omega 5-unsaturated compound. However, the dimethyl derivative of C22:1 omega 5-anacardic acid was a poor inhibitor of prostaglandin endoperoxide synthase and caused only moderate (32%) inhibition of lipoxygenase even at 135 microM. The possible role of prostaglandin endoperoxide synthase and lipoxygenase inhibition in the enhanced pest resistance of geraniums which produce the omega 5-AnAs is discussed.
authors.affiliation: Interdepartmental Graduate Program in Genetics, Pennsylvania State University, University Park 16802.
authors.forename: R
authors.initials: R
authors.lastname: Grazzini
authors.forename: D
authors.initials: D
authors.lastname: Hesk
authors.forename: E
authors.initials: E
authors.lastname: Heininger
authors.forename: G
authors.initials: G
authors.lastname: Hildenbrandt
authors.forename: C C
authors.initials: CC
authors.lastname: Reddy
authors.forename: D
authors.initials: D
authors.lastname: Cox-Foster
authors.forename: J
authors.initials: J
authors.lastname: Medford
authors.forename: R
authors.initials: R
authors.lastname: Craig
authors.forename: R O
authors.initials: RO
authors.lastname: Mumma
mesh_terms: D001241:Aspirin / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D010944:Plants / Q000032:analysis; D012459:Salicylates / Q000494:pharmacology*
chemical_list: D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D012459:Salicylates; D001241:Aspirin