Analysis of abnormalities of capillary CO2 exchange in vivo.
Capillary CO2 exchange in vivo is affected by several interdependent reactions and transport processes. A mathematical model that includes all the significant chemical and transport events that are presumed to occur during capillary gas exchange has been used to investigate the effect of inhibition of 1) erythrocyte HCO(3-)-Cl- exchange, 2) lung carbonic anhydrase (CA) activity with access to plasma, and 3) erythrocyte CA activity on overall pulmonary CO2 excretion (VCO2) during rest and moderate exercise. Any decrement in VCO2 due to inhibition of HCO(3-)-Cl- exchange and/or CA activity, should result in compensatory alterations in cardiac output and/or an increase in the mixed venous blood-to-alveolar PCO2 gradient [(delta PCO2)V-A] to restore steady-state VCO2. Our computations show that complete inhibition of erythrocyte anion exchange would require a compensatory increment in cardiac output of approximately 30-40% or an increase in (delta PCO2)V-A from 6 to 8.3 Torr at rest and from 12 to 15.6 Torr during moderate exercise, if lung CA activity is intact. In the absence of availability of lung CA activity to plasma, the necessary (delta PCO2)V-A is 10.5 Torr at rest and 19.5 Torr during moderate exercise. Complete inhibition of lung and erythrocyte CA activity is predicted to require (delta PCO2)V-A of 39.1 Torr at rest and 74.2 Torr during moderate exercise. These results suggest that HCO(3-)-Cl- exchange might not be vital to maintenance of CO2 transfer and perhaps has a more important role in minimizing the changes in plasma pH associated with microvascular gas exchange in vivo.
Bidani
A
A
Department of Medicine, University of Texas Medical Branch, Galveston 77550.
D001639:Bicarbonates / Q000378:metabolism; D001693:Biological Transport, Active; D002196:Capillaries / Q000378:metabolism*; D002245:Carbon Dioxide / Q000097:blood* / Q000378:metabolism; D002256:Carbonic Anhydrases / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D007474:Ion Exchange; D007700:Kinetics; D008168:Lung / Q000378:metabolism; D008954:Models, Biological; D011659:Pulmonary Gas Exchange / Q000502:physiology
D001639:Bicarbonates; D002712:Chlorides; D002245:Carbon Dioxide; D002256:Carbonic Anhydrases