Thyroid releasing hormone test in schizophrenic patients with post-psychotic depression.
1. TSH response to TRH was assessed in 25 patients meeting operationalized criteria for the post-psychotic depression syndrome and in an age and sex matched control group of 34 primary depressed patients. 2. A blunted TSH response was observed in 36% of the patients with post-psychotic depression. 3. The rate of blunted TSH response was similar for patients with secondary post-psychotic depression to those patients with primary depressions. 4. Demographic and clinical parameters did not distinguish those post-psychotic depressed patients who had a blunted response from those who did not. 5. A blunted TSH response to TRH did not predict which patients were more likely to have a favorable response when adjunctive imipramine was added to their on-going fluphenazine decanoate and benztropine regimen.
Siris
S G
SG
Hillside Hospital, Division of Long Island Jewish Medical Center, Glen Oaks, N.Y.
Frechen
K
K
Strahan
A
A
Cutler
J
J
Owen
K
K
Alvir
J
J
McCorry
T
T
D000328:Adult; D003866:Depressive Disorder / Q000175:diagnosis* / Q000209:etiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis*; D013973:Thyrotropin-Releasing Hormone
D013973:Thyrotropin-Releasing Hormone; D007099:Imipramine