[Functional inactivation of centrosome of mouse 3T3 cells by heat shock].
The microtubule assembly capacity of centrosome has been tested in mouse 3T3 cells. Following heat shock (30 min. at 43.5 degrees C), centrosomes display a total lack of microtubule nucleation. This stress leads to functional arrest of the organelle. The natural control of the activity of the centrosome is therefore questionable.
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U.A. C.N.R.S. 1135, Université Pierre-et-Marie-Curie, Paris.
D000818:Animals; D002460:Cell Line; D006358:Hot Temperature / Q000009:adverse effects*; D051379:Mice; D008870:Microtubules / Q000502:physiology*; D013312:Stress, Physiological
Inactivation fonctionnelle du centrosome de cellules 3T3 de souris par un choc thermique.