[Changes in cardiorespiratory function after radical esophagectomy by bilateral thoracotomy approach in dogs].
Twenty eight dogs (10-16 kg) were anesthetized with pentobarbital sodium, buprenorphine and pancuronium bromide followed by endotracheal intubation in the supine position. Twenty eight dogs were divided into two groups. Group 1 (n = 14) underwent thoracic esophagectomy with regional lymph nodes dissection under the right thoracotomy. Group 2 (n = 14) underwent the same manner of group 1. And left thoracotomy was added in the 5th intercostal space to completely dissect the left side regional lymph nodes. During surgical procedure, lactated Ringer's solution (L-R) were administered, L-R and Dextran 40 were given for postoperative fluid therapy. Cardiac output (CO), pulmonary arterial pressure (PAP), pulmonary wedge pressure (PWP), mean arterial pressure (AP), heart rate (PR), extravascular lung water (EVLW), blood gas analysis, pulmonary shunt rate (Qs/Qt), lung resistance (RL), dynamic lung compliance (CL) and colloid osmotic pressure (COP) were measured at preoperative phase and 1, 3, 6, 12 hrs after surgery. Significant differences were found in the left ventricular stroke work index (LVSWI), RL and the dosage of L-R between these dogs in groups 1 and 2. From these results, extended radical esophagotomy by bilateral thoracotomy approach for clinical cases seems to be possible under the exact indication and intensive perioperative care.
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First Department of Surgery, Kurume University School of Medicine, Japan.
D000818:Animals; D002302:Cardiac Output; D004285:Dogs; D004947:Esophagus / Q000601:surgery*; D015633:Extravascular Lung Water / Q000378:metabolism; D006439:Hemodynamics / Q000502:physiology*; D011184:Postoperative Period; D012119:Respiration / Q000502:physiology*; D013908:Thoracotomy / Q000379:methods*