title: 5,7-Dihydroxytryptamine injections increase glial fibrillary acidic protein in the hypothalamus of adult rats.
abstract: The distribution and levels of glial fibrillary acidic protein (GFAP) were determined in the adult rat hypothalamus following axotomy of serotonin (5-HT) neurons. Seven days after unilateral intrahypothalamic injection of the 5-HT neurotoxin, 5,7-dihydroxytryptamine, there was a marked increase in the number of GFAP-labelled astrocytes in the ipsilateral hypothalamus of 5,7-DHT-treated as compared to sham-treated rats. In addition, levels of GFAP were significantly increased 7 days after 5,7-DHT injection.
authors.affiliation: Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021.
authors.forename: M
authors.initials: M
authors.lastname: Frankfurt
authors.forename: J
authors.initials: J
authors.lastname: O'Callaghan
authors.forename: A
authors.initials: A
authors.lastname: Beaudet
mesh_terms: D015116:5,7-Dihydroxytryptamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D007839:Functional Laterality; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
chemical_list: D005904:Glial Fibrillary Acidic Protein; D015116:5,7-Dihydroxytryptamine