Diabetes mellitus induced in a dog after administration of corticosteroids and methylprednisolone pulse therapy.
An 8-year-old ovariohysterectomized Chow Chow was referred because of dermatologic lesions diagnosed as pemphigus foliaceus. Intolerance to orally administered corticosteroids necessitated the use of methylprednisolone pulse therapy. One week after treatment, diabetes mellitus was diagnosed on the basis of blood and urine test results. For 3 years after treatment, the dog has remained a well-regulated diabetic. Complete remission of pemphigus foliaceus is maintained by alternate-day, orally administered prednisone (0.5 mg/kg of body weight).
Jeffers
J G
JG
Department of Dermatology School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104.
Shanley
K J
KJ
Schick
R O
RO
D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000818:Animals; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D003907:Dexamethasone / Q000009:adverse effects / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D007262:Infusions, Intravenous / Q000662:veterinary; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D010392:Pemphigus / Q000188:drug therapy / Q000662:veterinary*; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D003907:Dexamethasone; D001379:Azathioprine; D011241:Prednisone; D008775:Methylprednisolone