Immunologic mechanisms in secretory otitis media-recent concepts (Part II).
Increasing evidence has been accumulated in the last few years associating immunological mechanisms in the pathogenesis of secretory otitis media. If immunological processes were found to be involved in both of the previously accepted experimental pathogenic models (Eustachian tube obstruction; microbiologically induced) of the disease, recently published data has provided evidence for a third, not Eustachian tube- or microbiological-dependent, exclusively immunological, experimental model. This suggests that immunological mechanisms are probably always involved in the pathogenesis of a disease that is known to be multifactorial in origin, and thus eventually make Immunology the single most important factor in secretory otitis media. In the present article these recent concepts are extensively reviewed by the authors.
Borges Dinis
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P
Otolaryngology Department, Hospital Pulido Valente, Lisboa, Portugal.
Gomes
A
A
D000361:Agammaglobulinemia / Q000150:complications; D000936:Antigen-Antibody Complex / Q000032:analysis; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D004432:Ear, Middle / Q000276:immunology; D006632:Histamine / Q000502:physiology; D006801:Humans; D017099:IgG Deficiency; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007223:Infant; D016131:Lymphocyte Subsets / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D009504:Neutrophils / Q000201:enzymology / Q000473:pathology; D010034:Otitis Media with Effusion / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D012008:Recurrence
D000936:Antigen-Antibody Complex; D001095:Arachidonic Acids; D016718:Arachidonic Acid; D006632:Histamine; D003165:Complement System Proteins