title: Human renin in transgenic mouse kidney is localized to juxtaglomerular cells.
abstract: To examine whether expression of human renin in the transgenic mouse kidney is regulated in a cell-specific manner, we have characterized monoclonal antibodies against human renin and determined the renin-production site by immunohistochemistry. By using a monoclonal antibody specific for human renin, A6-11-6, we demonstrated that human renin in the transgenic mouse kidney is localized to the juxtaglomerular cells of afferent arterioles.
authors.affiliation: Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Fukamizu
authors.forename: T
authors.initials: T
authors.lastname: Hatae
authors.forename: Y
authors.initials: Y
authors.lastname: Kon
authors.forename: M
authors.initials: M
authors.lastname: Sugimura
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
authors.forename: M
authors.initials: M
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Katsuki
authors.forename: K
authors.initials: K
authors.lastname: Murakami
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007606:Juxtaglomerular Apparatus / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D051379:Mice; D008822:Mice, Transgenic; D012083:Renin / Q000378:metabolism*; D000092502:Renin Inhibitors
chemical_list: D000911:Antibodies, Monoclonal; D012083:Renin; D000092502:Renin Inhibitors