Suppression of cell-mediated immunity by purified aflatoxin B1 in broiler chicks.
The effect of purified aflatoxin B1 on cell-mediated immunity (CMI) in broiler chicks was assessed using doses of 0.3 and 1 mg/kg feed from hatching to 6 weeks of age. Total lymphocyte and T lymphocyte counts and the 2,4-dinitrofluorobenzene skin sensitivity test, graft-versus-host reaction and nitroblue tetrazolium salt reduction tests were used to evaluate CMI. Both doses of aflatoxin B1, including the apparently nontoxic dose of 0.3 mg/kg feed, caused a significant (P less than 0.05) decline in CMI. The functional activity of splenic macrophages was decreased significantly (P less than 0.05) by both doses of the toxin.
Ghosh
R C
RC
Department of Veterinary Pathology, (Indira Gandhi Krishi Vishwa Vidyalaya), Anjora, Durg, India.
Chauhan
H V
HV
Jha
G J
GJ
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D002645:Chickens / Q000276:immunology*; D004139:Dinitrofluorobenzene / Q000008:administration & dosage; D006087:Graft vs Host Reaction / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D012882:Skin Tests; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects
D000348:Aflatoxins; D016604:Aflatoxin B1; D004139:Dinitrofluorobenzene