Concentrations of tyrosine, L-dihydroxyphenylalanine, dopamine, and 3-O-methyldopa in the cerebrospinal fluid of Parkinson's disease.
We determined the concentrations of tyrosine, L-3,4-dihydroxyphenylalanine (DOPA), dopamine (DA), and 3-O-methyldopa (3-OMD) in the cerebrospinal fluid (CSF) of parkinsonian patients and elevated potential interactions between the substances. We found a significant increase in tyrosine, and a significant decrease in DOPA, DA, and 3-OMD. We also found that for a given concentration of DOPA, DA and 3-OMD were proportional. In addition, the ratio of DA to 3-OMD was significantly shifted in favor of DA in parkinsonian patients.
Tohgi
H
H
Department of Neurology, Iwate Medical University, Morioka, Japan.
Abe
T
T
Takahashi
S
S
Nozaki
Y
Y
Kikuchi
T
T
D000368:Aged; D004295:Dihydroxyphenylalanine / Q000134:cerebrospinal fluid*; D004298:Dopamine / Q000134:cerebrospinal fluid*; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid*
D014443:Tyrosine; D004295:Dihydroxyphenylalanine; C008404:3-methoxytyrosine; D004298:Dopamine