Reduced expression of HLA-DP antigens on PWM stimulated T lymphocytes in patients suffering from psoriasis vulgaris.
24 psoriasis vulgaris patients were investigated for the expression of class II HLA antigens on the surface of PWM-stimulated T lymphocytes. The percentage of the expression of HLA-DP antigens ranged from 50.1% to 82.6% compared to a 100% level in healthy controls (p less than 0.005). No significant differences in the expression of HLA-DR antigens were observed. A higher frequency of some HLA antigens was found in the group of patients studied: B13 - 23.1%/6.2%, B 17 - 15.4%/7.1%, and Dw7 - 59.4%/15.8%.
Buc
M
M
Faculty of Medicine, Comenius University Bratislava, Czechoslovakia.
Munozová
H
H
Russ
G
G
Busová
B
B
Vlcek
F
F
Rovenský
J
J
D003208:Concanavalin A / Q000494:pharmacology; D015870:Gene Expression; D006682:HLA-DP Antigens / Q000096:biosynthesis*; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D011565:Psoriasis / Q000276:immunology*; D011863:Radioimmunoassay; D013601:T-Lymphocytes / Q000276:immunology*
D006682:HLA-DP Antigens; D006684:HLA-DR Antigens; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A