Assays for lupus anticoagulant: the sensitivity of different assays.
Fifty patients with systemic lupus erythematosus were studied for the presence of lupus anticoagulant using three different assays--kaolin clotting time, platelet neutralization test, and tissue thromboplastin inhibition test. Lupus anticoagulant could be detected in seven cases (14%) with the use of one test in cases with a partial prothrombin time with kaolin more than five seconds greater than normal. The detection rate rose to 20% (10 cases) when using all three tests, so a panel of three assays could identify lupus patients apparently at risk for thrombotic complications.
Jain
A
A
Department of Haematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Dash
S
S
Marwaha
N
N
Deodhar
S D
SD
Sehgal
S
S
D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology*; D001780:Blood Coagulation Tests; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000097:blood*
D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor