[Study of the dependence of the permeability of phosphatidylcholine liposomes for glucose on their prostaglandin level].
It was found that incorporation into phosphatidylcholine monolamellar liposomes of prostaglandin E1 or its synthetic analog containing a phenol group instead of a carboxyl one leads to a significant decrease of the liposome permeability for glucose. The prostaglandin E1 analog appeared to be more membrane-active one. The data obtained were compared with the experimentally established changes in the monolayer compressibility. The experimental results are discussed in terms of a theoretical model which entails that this permeability is proportional to the number of dynamic whose diameter markedly exceeds the molecular size of glucose.
Sorokina
A D
AD
Ianopol'skaia
N D
ND
Vibas
I M
IM
Iaĭlenko
T L
TL
Voguslavskiĭ
L I
LI
D000527:Alprostadil / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism*; D010539:Permeability; D010713:Phosphatidylcholines / Q000378:metabolism*
D008081:Liposomes; D010713:Phosphatidylcholines; D000527:Alprostadil; D005947:Glucose
Issledovanie zavisimosti pronitsaemosti fosfatilkholinovykh liposom dlia gliukozy ot soderzhaniia v nikh prostaglandina.