Effects of amphetamine on T-cell immune response in mice.
Mice chronically injected with amphetamine (0.4 mg/kg/day) showed a reduction in thymus and spleen cellularity, and in peripheral T lymphocyte population. The blastogenic response of spleen lymphoid cells was assessed and amphetamine was found to inhibit T-cell proliferation. Amphetamine also reduced the capacity of mice to the development and passive transfer of immunity to Listeria monocytogenes.
Freire-Garabal
M
M
Department of Pharmacology, School of Medicine, University of Santiago de Compostela, Spain.
Balboa
J L
JL
Núñez
M J
MJ
Castaño
M T
MT
Llovo
J B
JB
Fernández-Rial
J C
JC
Belmonte
A
A
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D005260:Female; D016219:Immunotherapy, Adoptive; D007958:Leukocyte Count / Q000187:drug effects; D008089:Listeria monocytogenes / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D000661:Amphetamine