Direct effect of angiotensin II on in-vitro perfused rabbit ovary.
The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.
Kuo
T C
TC
Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics, Baltimore, MD 21205.
Endo
K
K
Dharmarajan
A M
AM
Miyazaki
T
T
Atlas
S J
SJ
Wallach
E E
EE
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005260:Female; D008833:Microcirculation / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D009865:Oocytes / Q000187:drug effects; D009924:Organ Culture Techniques; D006080:Ovarian Follicle / Q000098:blood supply / Q000648:ultrastructure; D010053:Ovary / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects; D010477:Perfusion; D011817:Rabbits; D012504:Saralasin / Q000494:pharmacology
D006063:Chorionic Gonadotropin; D000804:Angiotensin II; D012504:Saralasin