Semi-synthetic approaches to novel penicillins.
The first part of this account of the discovery of penicillin, published in last month's issue of TIBS, concluded with the detection of 6-beta-amino-penicillanic acid (6-APA), the nucleus of the penicillin structure. The exploitation of 6-APA led to the preparation of a range of clinically important semi-synthetic penicillins, which is described in this article.
Nayler
J H
JH
D010406:Penicillins / Q000138:chemical synthesis*
D010406:Penicillins