["Masked" autoantibodies from the serum of healthy blood donors cross-reacting with DNA and bacterial lipopolysaccharides].
The "masked" autoantibodies with polyspecific activity were found in the serum of healthy donors. It is shown that these antibodies are able to react with antigens after the ion exchange chromatography with QAE-sephadex. It was found that these "masked" antibodies are able to cross-react with DNA and lipopolysaccharides of wide-spread species of bacteria. The possible role of these antibodies as in protection of organism from the external antigens as in the origin of autoimmune diseases is discussed.
Lekakh
I V
IV
Rott
G M
GM
Poverennyĭ
A M
AM
D001323:Autoantibodies / Q000032:analysis*; D001782:Blood Donors; D002852:Chromatography, Ion Exchange; D003429:Cross Reactions; D004269:DNA, Bacterial / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D012485:Salmonella typhi / Q000276:immunology*; D012761:Shigella boydii / Q000276:immunology*
D001323:Autoantibodies; D004269:DNA, Bacterial; D008070:Lipopolysaccharides
"Skrytye" autoantitela iz syvorotki krovi zdorovykh donorov, perekrestno reagiruiushchie s DNK i bakterial'nymi lipopolisakharidami.