title: The QKd interval in panic disorder: an assessment of end-organ thyroid hormone responsivity.
abstract: The QKd interval was utilized as a presumptive index of end-organ thyroid hormone effect to test the hypothesis that patients with panic disorder might have abnormal tissue-level responsivity to normal levels of peripherally circulating thyroid hormones. No significant differences in QKd intervals were found between 15 patients with panic disorder (230 +/- 50 msec) and 20 normal controls (224 +/- 29 msec) while drug-free. These findings suggest that patients with panic disorder have normal tissue-level responsivity to thyroid hormone.
authors.affiliation: Section on Anxiety and Affective Disorders, Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892.
authors.forename: M B
authors.initials: MB
authors.lastname: Stein
authors.forename: J
authors.initials: J
authors.lastname: Muir-Nash
authors.forename: T W
authors.initials: TW
authors.lastname: Uhde
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D010200:Panic / Q000502:physiology*; D012016:Reference Values; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013963:Thyroid Hormones / Q000097:blood / Q000502:physiology*; D013997:Time Factors
chemical_list: D012738:Sex Hormone-Binding Globulin; D013963:Thyroid Hormones