title: Effects of environmental exposure on carbon polysulphone composites.
abstract: In vivo and in vitro studies were designed to characterize the material degradation associated with implantation of carbon fibre-reinforced polysulphone (C/PS). Composite plates were compression moulded for both studies, and a fibre orientation of 0 degrees with the long axis and a fibre volume fraction of approximately 55% were used. The in vitro experiment involved soaking three groups of four plates each at 4, 12 and 26 wk in 0.9% saline solution at 37 degrees C. The plates were measured for weight gain after each time period and mechanically tested non-destructively in four-point bending to determine modulus. The in vivo experiment involved implanting three groups of eight composite plates (24 total) subcutaneously in the abdomens of 12 rabbits (two implants/animal). Implants were harvested at 4, 12 and 26 wk after implantation and evaluated for changes in weight or modulus of elasticity. In vitro results showed a statistically significant (P less than 0.05 paired t-test) increase in weight for all time periods: 0.41, 1.25 and 0.93% weight gain for the 4, 12 and 26 wk periods respectively. In vivo results were similar to those in vitro: 0.66, 1.06 and 1.15% weight gain for the 4, 12 and 26 wk periods respectively (P less than 0.05 paired t-test). There was no statistically significant difference between the pre- and post-implantation modulus of elasticity for any time period in vivo or in vitro. However, in both studies, on average, the modulus tended to increase with environmental exposure.
authors.affiliation: University of Medicine and Dentistry of New Jersey--New Jersey Medical School, Newark 07103.
authors.forename: M C
authors.initials: MC
authors.lastname: Zimmerman
authors.forename: H L
authors.initials: HL
authors.lastname: Scalzo
authors.forename: J R
authors.initials: JR
authors.lastname: Parsons
authors.forename: A H
authors.initials: AH
authors.lastname: Torop
authors.forename: T S
authors.initials: TS
authors.lastname: Lin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002244:Carbon / Q000737:chemistry*; D003188:Composite Resins; D003343:Corrosion; D004548:Elasticity; D004781:Environmental Exposure; D008422:Materials Testing; D008970:Molecular Weight; D019736:Prostheses and Implants; D011817:Rabbits; D013055:Spectrophotometry, Infrared; D013450:Sulfones / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D003188:Composite Resins; D013450:Sulfones; D002244:Carbon