title: Cerebral blood flow decreases with time whereas cerebral oxygen consumption remains stable during hypothermic cardiopulmonary bypass in humans.
abstract: Recent investigations demonstrate that cerebral blood flow (CBF) progressively declines during hypothermic, nonpulsatile cardiopulmonary bypass (CPB). If CBF declines because of brain cooling, the cerebral metabolic rate for oxygen (CMRO2) should decline in parallel with the reduction in CBF. Therefore we studied the response of CBF, the cerebral arteriovenous oxygen content difference (A-VDcereO2) and CMRO2 as a function of the duration of CPB in humans. To do this, we compared the cerebrovascular response to changes in the PaCO2. Because sequential CBF measurements using xenon 133 (133Xe) clearance must be separated by 15-25 min, we hypothesized that a time-dependent decline in CBF would accentuate the CBF reduction caused by a decrease in PaCO2, but would blunt the CBF increase associated with a rise in PaCO2. We measured CBF in 25 patients and calculated the cerebral arteriovenous oxygen content difference using radial arterial and jugular venous bulb blood samples. Patients were randomly assigned to management within either a lower (32-48 mm Hg) or higher (50-71 mm Hg) range of PaCO2 uncorrected for temperature. Each patient underwent two randomly ordered sets of measurements, one at a lower PaCO2 and the other at a higher PaCO2 within the respective ranges. Cerebrovascular responsiveness to changes in PaCO2 was calculated as specific reactivity (SR), the change in CBF divided by the change in PaCO2, expressed in mL.100 g-1.min-1.mm Hg-1.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
authors.forename: D S
authors.initials: DS
authors.lastname: Prough
authors.forename: A T
authors.initials: AT
authors.lastname: Rogers
authors.forename: D A
authors.initials: DA
authors.lastname: Stump
authors.forename: R C
authors.initials: RC
authors.lastname: Roy
authors.forename: A R
authors.initials: AR
authors.lastname: Cordell
authors.forename: J
authors.initials: J
authors.lastname: Phipps
authors.forename: C L
authors.initials: CL
authors.lastname: Taylor
mesh_terms: D000704:Analysis of Variance; D000758:Anesthesia; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000097:blood; D002315:Cardiopulmonary Bypass; D002560:Cerebrovascular Circulation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007036:Hypothermia, Induced; D009204:Myocardial Revascularization; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D013997:Time Factors; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes; D002245:Carbon Dioxide; D010100:Oxygen