Effects of hypoxia on fetal rat brain metabolism studied in utero by 31P-NMR spectroscopy.
An animal model of perinatal asphyxia, in which near-term fetal rats are subjected to-short periods of hypoxia, has been investigated by 31P-NMR spectroscopy. Changes in the high-energy phosphates and intracellular pH of the fetal rat brain were measured in utero following ligation of the placental blood vessels, and during reperfusion after a 20-min period of occlusion. The hypoxia-induced changes observed in the fetal brain were substantially slower than in the adult, and were completely reversible after 20 min of hypoxia.
O'Shaughnessy
C T
CT
Department of Physiological Sciences, University of Manchester, U.K.
Lythgoe
D J
DJ
Butcher
S P
SP
Kendall
L
L
Wood
B
B
Steward
M C
MC
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate