Combined radioprotection by preirradiation peroral cystamine and postirradiation glucan administration.
The possibilities of combined radioprotection, using preirradiation peroral cystamine and postirradiation intraperitoneal glucan administration in sublethally and lethally whole-body gamma-irradiated mice were investigated. The results demonstrated at least additive radioprotective effects of both agents, manifested in the enhancement of postirradiation haemopoietic recovery and increased survival of irradiated mice. The effects appear to depend on the sequential cell protection mediated by cystamine and enhanced haemopoietic repopulation induced by glucan.
Pospísil
M
M
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Netíková
J
J
Pipalová
I
I
Jarý
J
J
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D003538:Cystamine / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D005269:Femur; D005720:Gamma Rays; D043326:Glucan 1,3-beta-Glucosidase; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D014916:Whole-Body Irradiation; D001617:beta-Glucosidase / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D001617:beta-Glucosidase; D043326:Glucan 1,3-beta-Glucosidase; D003538:Cystamine