title: [Effects of allapinin on sodium currents in isolated neurons of the trigeminal ganglia and cardiomyocytes of rats].
abstract: Block of sodium currents by allapinin (diterpene alkaloid with strong antiarrhythmic properties) was investigated in isolated, voltage clamped rat trigeminal neurons and cultured neonatal rat single ventricular myocytes. Allapinin produces a decrease in sodium current amplitude without any changes in voltage dependent properties. Possible differences between the mechanisms of antiarrhythmic effect of diterpene alkaloids and classic antiarrhythmic agents have been analysed.
authors.forename: A E
authors.initials: AE
authors.lastname: Valeev
authors.forename: A N
authors.initials: AN
authors.lastname: Verkhratskiĭ
authors.forename: F N
authors.initials: FN
authors.lastname: Dzhakhangirov
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D002478:Cells, Cultured; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000166:cytology*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D051381:Rats; D012668:Trigeminal Ganglion / Q000187:drug effects* / Q000502:physiology
chemical_list: D000889:Anti-Arrhythmia Agents; C051402:allapinin; D002118:Calcium; D000157:Aconitine
vernacular_title: Vliianie allapinina na natrievye toki izolirovannykh neĭronov trigeminal'nykh gangliev i kardiomiotsitov krys.