Metabolism of E1 and E2 in Ishikawa endometrium carcinoma cells: influence of TNF alpha.
The metabolism of estrone (E1) and estradiol (E2) by Ishikawa endometrial carcinoma cells and its alteration by TNF alpha treatment was studied. Whereas this cell line practically does not respond to estrogens, it is very sensitive to TNF with respect to growth inhibition and other parameters. E2 and E1 were found to be metabolized by this cell line whereby the main metabolite for both estrogens was estriol. TNF significantly increased the rate of E1 and E2 conversion.
Kirchebener
P
P
Department of Obstetrics and Gynecology, University Hospital, Innsbruck, Austria.
Marth
C
C
Mayer
I
I
Daxenbichler
G
G
D002452:Cell Count; D002455:Cell Division; D004958:Estradiol / Q000378:metabolism*; D004970:Estrone / Q000378:metabolism*; D005260:Female; D006801:Humans; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D014594:Uterine Neoplasms / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha; D004970:Estrone; D004958:Estradiol