Streptococcus sanguis survival in K-Sol. Comparison of gentamicin and the fluoroquinolone antibiotics.
Viridans streptococci are poorly covered by gentamicin sulfate in corneal storage medium. To evaluate possible antibiotic alternatives among the newer broad-spectrum fluoroquinolone antibiotics, we compared the survival of the viridans representative Streptococcus sanguis in K-Sol with gentamicin sulfate (100 mg/L), norfloxacin (250 mg/L), ciprofloxacin lactate (250 mg/L), ofloxacin (250 mg/L), or no antibiotic. At 23 degrees C, K-Sol with gentamicin produced a 2-log kill by 80 minutes. By comparison, only one of the others (norfloxacin) had achieved a 2-log kill by 4 hours. At 4 degrees C, all antibiotics differed little from the control, and none was superior to gentamicin.
Glaros
D S
DS
Cornea Service, University of Maryland School of Medicine, Baltimore, MD 21201.
Nirankari
V S
VS
Baer
J C
JC
Bauer
S A
SA
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002809:Chondroitin Sulfates / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D015169:Colony Count, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D006531:HEPES / Q000494:pharmacology*; D009643:Norfloxacin / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D013298:Streptococcus sanguis / Q000187:drug effects* / Q000254:growth & development
D000890:Anti-Infective Agents; D005839:Gentamicins; C051174:K-Sol preserving medium; D002939:Ciprofloxacin; D002809:Chondroitin Sulfates; D015242:Ofloxacin; D009643:Norfloxacin; D006531:HEPES