Naproxen induced pseudoporphyria in juvenile chronic arthritis.
We report 6 cases of porphyria-like skin reactions in children taking naproxen for juvenile chronic arthritis. The lesions mimicked either erythropoietic protoporphyria or porphyria cutanea tarda, with both forms occurring in 2 patients. Biochemical studies excluded abnormal porphyrin metabolism.
Allen
R
R
Department of Rheumatology, Children's Hospital, Sydney, NSW, Australia.
Rogers
M
M
Humphrey
I
I
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000188:drug therapy* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009288:Naproxen / Q000009:adverse effects* / Q000627:therapeutic use; D011164:Porphyrias / Q000139:chemically induced* / Q000378:metabolism; D011166:Porphyrins / Q000378:metabolism
D011166:Porphyrins; D009288:Naproxen