title: The primary structure of Tetrahymena profilin.
abstract: The cDNA of Tetrahymena profilin was cloned and sequenced. The deduced product has a molecular mass of 16,785 Da which is the largest among profilins known so far. Tetrahymena profilin shows higher homologies with lower eukaryotic profilins than with mammalian profilins. Although the homologies with mammalian and lower eukaryotic profilins are only 20-29% which is the lowest one among lower eukaryotic profilins, the N- and C-terminal regions of Tetrahymena profilin are considerably conserved as those in other profilins, suggesting that these regions are responsible for the essential properties common to profilins.
authors.affiliation: Institute of Biological Sciences, University of Tsukuba, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Edamatsu
authors.forename: M
authors.initials: M
authors.lastname: Hirono
authors.forename: T
authors.initials: T
authors.lastname: Takemasa
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D003001:Cloning, Molecular; D003285:Contractile Proteins; D004247:DNA / Q000235:genetics; D008840:Microfilament Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D051304:Profilins; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping; D013769:Tetrahymena pyriformis / Q000235:genetics*
chemical_list: D003285:Contractile Proteins; D008840:Microfilament Proteins; D051304:Profilins; D012333:RNA, Messenger; D004247:DNA