title: Effects of an acidic calcium phosphate solution and the intraoral fluoride-releasing device on dental caries and fluoride uptake in rats.
abstract: This investigation comprised two studies evaluating the effects of an acidic calcium phosphate solution (CPS) on fluoride uptake in the enamel, glycolysis of dental plaque, the incidence of dental caries and urinary fluoride concentrations of rats wearing an intraoral fluoride-releasing device (IFRD). In the first study, CPS-fluoride treatment preceded the cariogenic challenge. In the second study, the cariogenic challenge preceded the treatments. In the first study, CPS treatments increased the ability of enamel to bind fluoride. However, the enamel-bound fluoride exerted a negligible effect on plaque glycolysis as measured by the pH decrease after sucrose challenge. In the second study CPS augmented the caries inhibition for both the sulcal-morsal and buccal-lingual surfaces. In both studies the IFRD significantly restricted the development of carious enamel on the sulcal-morsal surfaces and caused elevated concentrations of fluoride in the urine independent of CPS treatments.
authors.affiliation: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Md.
authors.forename: R J
authors.initials: RJ
authors.lastname: Shern
authors.forename: D B
authors.initials: DB
authors.lastname: Mirth
authors.forename: A
authors.initials: A
authors.lastname: Bartkiewicz
authors.forename: E
authors.initials: E
authors.lastname: Monell-Torrens
authors.forename: S H
authors.initials: SH
authors.lastname: Li
authors.forename: L C
authors.initials: LC
authors.lastname: Chow
mesh_terms: D016924:Actinomyces viscosus / Q000502:physiology; D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D002130:Calcium Phosphates / Q000008:administration & dosage / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D003731:Dental Caries / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology*; D003743:Dental Enamel / Q000187:drug effects* / Q000378:metabolism; D003773:Dental Plaque / Q000378:metabolism / Q000382:microbiology; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000652:urine; D006019:Glycolysis / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D015994:Incidence; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D016037:Single-Blind Method; D013295:Streptococcus mutans / Q000502:physiology; D016986:Streptococcus sobrinus / Q000502:physiology
chemical_list: D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous; D005459:Fluorides