Lactic acid kinetics in respiratory alkalosis.
OBJECTIVE
To evaluate the impact of respiratory alkalosis on the elimination of intravenously infused lactate.


METHODS
Prospective, randomized, crossover study.


METHODS
Medical ICU of a university hospital.


METHODS
Eight patients treated by ventilatory support for neurologic or neuromuscular diseases.


METHODS
Patients were investigated on two occasions: during normoventilation (pH 7.42 +/- 0.1, PCO2 41 +/- 2 torr [5.5 +/- 0.2 kPa]) and during respiratory alkalosis (pH 7.59 +/- 0.1, PCO2 27 +/- 2 torr [3.6 +/- 0.2 kPa]) induced by controlled hyperventilation. To evaluate lactate elimination kinetics, 1 mmol/kg body weight of L-lactic acid was infused over 5 mins.


RESULTS
Arterial lactate concentrations and blood gas values were determined before and repeatedly after the infusion. Lactate elimination variables were calculated from the plasma curve by using a two-compartment model. Respiratory alkalosis increased plasma lactate from 1.56 +/- 0.1 to 2.49 +/- 0.2 mmol/L (p less than .001). The lactate elimination half-life increased from 4.57 +/- 0.2 mins at pH 7.42, to 9.96 +/- 1.1 mins during pH 7.59 (p less than .01), and beta half-life increased from 12.2 +/- 1.9 to 44.1 +/- 1 mins (p less than .01). Whole-body clearance decreased 40% from 24.2 +/- 2.9 to 14.3 +/- 2.0 mL/kg body weight-min (p less than .01).


CONCLUSIONS
Respiratory alkalosis increases the basal concentration of plasma lactate and decreases clearance of infused lactic acid. These findings provide further evidence of the adverse effects of alkalosis.
Druml
W
W
1st Department of Medicine, University of Vienna, Austria.
Grimm
G
G
Laggner
A N
AN
Lenz
K
K
Schneeweiss
B
B
D000368:Aged; D000472:Alkalosis, Respiratory / Q000097:blood* / Q000628:therapy; D005260:Female; D006207:Half-Life; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006985:Hyperventilation / Q000097:blood; D007262:Infusions, Intravenous; D007773:Lactates / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial; D013997:Time Factors
D007773:Lactates; D019344:Lactic Acid