Stimulation of U937 human monocytic cells by thrombin results in inositol trisphosphate formation and the mobilisation of intracellular Ca2+ but not the synthesis of thromboxane B2.
Joseph
S
S
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.
MacDermot
J
J
D000262:Adenylyl Cyclases / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002454:Cell Differentiation; D002460:Cell Line; D002462:Cell Membrane / Q000201:enzymology; D005576:Colforsin / Q000494:pharmacology; D003470:Culture Media; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D007700:Kinetics; D009000:Monocytes; D013917:Thrombin / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000096:biosynthesis*
D003470:Culture Media; D005576:Colforsin; D013929:Thromboxane B2; D015544:Inositol 1,4,5-Trisphosphate; D013917:Thrombin; D000262:Adenylyl Cyclases; D002118:Calcium