title: Expression of fragile-X in a female fetus diagnosed after chorionic villus sampling.
abstract: Study of different tissues of an aborted female fetus showed similar levels of fragile-X expression (6.3-9.2 per cent) and of early replication of the FRAXA-positive cells (50-66 per cent) in fetal tissues. Different culture media did not significantly affect either investigation. It is suggested that the distribution of X-inactivation in FRAXA-positive chorionic villus cells of a female fetus might indicate her future phenotype.
authors.affiliation: Department of Clinical Genetics, Maternity Hospital, Birmingham, U.K.
authors.forename: T
authors.initials: T
authors.lastname: Webb
mesh_terms: D002478:Cells, Cultured; D015193:Chorionic Villi Sampling; D004261:DNA Replication; D004303:Dosage Compensation, Genetic; D005260:Female; D005600:Fragile X Syndrome / Q000175:diagnosis*; D006801:Humans; D007668:Kidney / Q000166:cytology; D009132:Muscles / Q000166:cytology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012867:Skin / Q000166:cytology