Morphological transformation of microglia in vitro.
Isolated microglia underwent in vitro morphological transformation to ameboid, rod-shaped and ramified forms in response to several cytokines, factors from astrocytes, or factors which affect macrophage function. These morphological transformations were reversible. Examination of the enzymatic activity, superoxide anion formation and proliferative activity of these transformed microglia indicated that the ameboid forms were activated, rod-shaped microglia were proliferating, and the ramified forms were resting microglia.
Suzumura
A
A
Department of Neurology, School of Medicine, Fujita Health University, Japan.
Marunouchi
T
T
Yamamoto
H
H
D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007378:Interleukins / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology* / Q000187:drug effects; D008648:Mesoderm / Q000166:cytology*; D051379:Mice; D008809:Mice, Inbred C3H; D009457:Neuroglia / Q000166:cytology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D007378:Interleukins; D008070:Lipopolysaccharides; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D013755:Tetradecanoylphorbol Acetate