title: The management of IIB osteosarcoma. Experience from 1976 to 1985.
abstract: From 1976 to 1985, 75 IIB osteosarcomas have been treated out of a total of 98 osteosarcomas at the authors' institution. Because of the effective chemotherapy including high-dose methotrexate administered during this time period, the surgical management changed, and only ten patients out of the 75 IIB osteosarcomas required an amputation. The overall result of 76.7% of disease-free, three-year survival was equally distributed regardless of the surgical procedure. Endoprosthesis, resection with or without grafts, and rotationplasties, as well as amputations, revealed similar results. No negative influence from the limb-sparing surgery could be observed.
authors.affiliation: Orthopaedic University Clinic of Vienna, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Kropej
authors.forename: C
authors.initials: C
authors.lastname: Schiller
authors.forename: P
authors.initials: P
authors.lastname: Ritschl
authors.forename: M
authors.initials: M
authors.lastname: Salzer-Kuntschik
authors.forename: R
authors.initials: R
authors.lastname: Kotz
mesh_terms: D000293:Adolescent; D000328:Adult; D000671:Amputation, Surgical / Q000592:standards* / Q000706:statistics & numerical data; D001317:Austria / Q000453:epidemiology; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D016025:Bone Transplantation / Q000592:standards / Q000706:statistics & numerical data; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D010027:Osteotomy / Q000592:standards* / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000453:epidemiology; D019736:Prostheses and Implants / Q000706:statistics & numerical data; D013524:Surgical Flaps / Q000592:standards / Q000706:statistics & numerical data; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: D008727:Methotrexate