[The influence of glucosamine on the antiexudative effect of nonsteroidal anti-inflammatory agents].
The study of the antiexudative activities of voltaren, indomethacin and piroxicam in combination with glucosamine on the model of carrageenan inflammation showed that the combination makes it possible to decrease the effective doses of nonsteroidal anti-inflammatory drugs by 2-2.7 times with the preservation of the pronounced antiexudative activity. A diverse influence of aminosugar on the anti-inflammatory effect of nonsteroidal anti-inflammatory drugs depending on the sequence and routes of administration is connected with their membrane mechanisms and metabolic features of amino sugar.
Zupanets
I A
IA
Drogovoz
S M
SM
Bezdetko
N V
NV
Rechkiman
I E
IE
Semenov
A N
AN
D000208:Acute Disease; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005122:Exudates and Transudates / Q000187:drug effects*; D005944:Glucosamine / Q000627:therapeutic use*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D005944:Glucosamine
Vliianie gliukozamina na antiékssudativnyĭ éffekt nesteroidnykh protivovospalitel'nykh svoĭstv.