Studies of adenovirus subtypes and down-regulation of HLA class I expression: correlations to natural-killer-mediated cytolysis.
Natural killer cell (NK) cytotoxicity historically has been accepted to be unrelated to major histocompatibility complex (MHC) expression. However, recent studies have indicated that a decrease in MHC antigen expression leads to a concomitant increase in NK cytotoxicity. We have, therefore, studied the alteration of HLA class I expression by 6 types of adenovirus in the human cell line HEp-2. We conclude that for the 6 types of adenovirus tested, HLA class I expression and NK cytotoxicity are not interrelated.
Bosse
D
D
Biological Products Branch, Centers for Disease Control, Atlanta, Ga.
Ades
E
E
D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics* / Q000502:physiology; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D003602:Cytotoxicity, Immunologic / Q000235:genetics* / Q000276:immunology; D015536:Down-Regulation / Q000235:genetics*; D015967:Gene Expression Regulation, Viral / Q000502:physiology*; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology*; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology; D014407:Tumor Cells, Cultured / Q000276:immunology / Q000378:metabolism / Q000473:pathology
D015395:Histocompatibility Antigens Class I