title: Genetic resistance to a Marek's disease transplantable tumor cell line in chicken lines selected for different immunological characters.
abstract: The tumor incidence and mortality of Marek's disease (MD) were determined for 471 progeny from four pairs of lines two-way selected for different immunological characters: graft versus host reaction (GVHR) competence, IgG levels, antibody response to rabbit serum albumin (RSA), and anaphylactic shock to BSA. All chicks were inoculated at 1 wk of age with 1 to 2 x 10(6) viable cells of a MD lymphoblastoid cell line, MDCC-MSB1-41C (41 C). Tumor incidence differed significantly between the high (H) and low (L) lines of each GVHR-, IgG-, RSA-, or BSA-selected group. There were also significant differences in mortality rates between H and L lines of all selected groups. The IgG-H, BSA-H, and RSA-H lines were more resistant than their respective L lines. The H line of the GVHR-selected lines was more susceptible than the L line. Tumor regression could be detected only in the IgG- and RSA-selected lines. No definite correlation could be found between genetic resistance to 41C and genetic resistance to MD virus.
authors.affiliation: Faculty of Applied Biological Science, Hiroshima University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: I
authors.initials: I
authors.lastname: Okada
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: H
authors.initials: H
authors.lastname: Okabayashi
authors.forename: M
authors.initials: M
authors.lastname: Mizutani
mesh_terms: D000707:Anaphylaxis / Q000235:genetics / Q000662:veterinary; D000818:Animals; D000917:Antibody Formation / Q000235:genetics; D001947:Breeding; D002460:Cell Line; D002645:Chickens; D006087:Graft vs Host Reaction / Q000235:genetics; D007113:Immunity, Innate / Q000235:genetics; D007074:Immunoglobulin G / Q000235:genetics; D008380:Marek Disease / Q000235:genetics / Q000276:immunology* / Q000401:mortality; D012709:Serum Albumin / Q000276:immunology; D012710:Serum Albumin, Bovine / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D012709:Serum Albumin; D012710:Serum Albumin, Bovine