Effects of 3-aminobenzamide on induction of multiorgan carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine in hamsters.
The effects of an inhibitor of poly(ADP-ribose)polymerase, 3-aminobenzamide (ABA), on N-nitrosobis(2-hydroxypropyl)amine (BHP)-induced pancreas, liver, gallbladder and lung carcinogenesis in Syrian golden hamsters were investigated. Animals were given either BHP alone, by subcutaneous injection at a dose of 500 mg/kg body weight, or in combination with an intraperitoneal injection of ABA 30 min after the BHP at a dose of 300 or 600 mg/kg body weight once a week for 5 weeks, and then killed 35 weeks after the commencement of the experiment. ABA exerted inhibitory effects on pancreas and lung carcinogenesis induced by BHP, with mean numbers of lesions (including hyperplasias and carcinomas) being significantly decreased compared with the BHP-alone group values, while no significant effect was observed on liver or gallbladder carcinogenesis. These results suggest that the effects of ABA on carcinogenesis depend on the target organ as well as the chemical carcinogen examined.
Tsujiuchi
T
T
Department of Oncological Pathology, Nara Medical College, Japan.
Tsutsumi
M
M
Denda
A
A
Amanuma
T
T
Kondoh
S
S
Kamino
K
K
Konishi
Y
Y
D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D001835:Body Weight / Q000502:physiology; D002273:Carcinogens / Q000633:toxicity*; D006224:Cricetinae; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008168:Lung / Q000033:anatomy & histology / Q000187:drug effects; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines / Q000633:toxicity*; D009929:Organ Size / Q000502:physiology; D010179:Pancreas / Q000033:anatomy & histology / Q000187:drug effects; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors
D001549:Benzamides; D002273:Carcinogens; D009602:Nitrosamines; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C012457:diisopropanolnitrosamine; C025160:3-aminobenzamide