Effect of repeated oral administration of tobacco snuff on natural killer-cell activity in the rat.
The possible immune effect of oral snuff was investigated. In male adult rats, oral snuff given for 15 weeks significantly decreased NK-cell activity in peripheral blood against murine NK cell-sensitive target cells (YAC-1 lymphoma).
Johansson
S L
SL
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.
Hirsch
J M
JM
Johnson
D R
DR
D000284:Administration, Oral; D000818:Animals; D002860:Chromium Radioisotopes; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000502:physiology; D008223:Lymphoma / Q000473:pathology; D008297:Male; D010947:Plants, Toxic; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014030:Tobacco, Smokeless / Q000009:adverse effects*
D002860:Chromium Radioisotopes