title: Acrylamide is genotoxic to the somatic and germ cells of Drosophila melanogaster.
abstract: The genotoxic effects of acrylamide, a recently detected carcinogen, have been studied in the somatic (wing primordia) and germ cells of Drosophila melanogaster by the wing mosaic assay and the sex-linked recessive lethal test respectively. Larvae, 72 +/- 4 h old, were exposed to 6 different concentrations of acrylamide ranging between 0.25 mM and 5.0 mM in instant medium for 48 h. It is observed that acrylamide is both mutagenic and recombinogenic in the wing disc cells and induces sex-linked recessive lethals.
authors.affiliation: Department of Zoology, Berhampur University, Orissa, India.
authors.forename: N K
authors.initials: NK
authors.lastname: Tripathy
authors.forename: K K
authors.initials: KK
authors.lastname: Patnaik
authors.forename: M J
authors.initials: MJ
authors.lastname: Nabi
mesh_terms: D020106:Acrylamide; D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000187:drug effects / Q000235:genetics*; D005260:Female; D005804:Genes, Lethal; D005808:Genes, Recessive; D005854:Germ Cells / Q000187:drug effects; D008297:Male; D009030:Mosaicism / Q000235:genetics; D009152:Mutagenicity Tests; D009154:Mutation; D010641:Phenotype
chemical_list: D000178:Acrylamides; D020106:Acrylamide