title: Effect of lovastatin on the interaction between high density lipoprotein and cultured rat adrenocortical cells.
abstract: Preincubation of rat adrenocortical cells with lovastatin inhibits high density lipoprotein (HDL3) interaction with rat adrenocortical cells in a dose- and time-dependent fashion. Lovastatin causes a decrease in the number of binding sites and a moderate increase in the affinity of HDL binding to cells. Lovastatin also produced a dose- and time-dependent inhibition of cholesterol synthesis in these cells. Dose-dependence, but not time-dependence, of the inhibition of cholesterol synthesis, correlates with that of HDL binding (r = 0.91, P less than 0.004). Incubation of cells with lovastatin for up to 24 h does not change their free or total cholesterol content. The inhibitory effect was apparently not due to a modification of HDL by lovastatin. These results indicate that lovastatin causes a down-regulation of HDL binding sites on cultured rat adrenocortical cells.
authors.affiliation: Institute of Experimental Cardiology, U.S.S.R. Cardiology Research Center, Moscow.
authors.forename: D
authors.initials: D
authors.lastname: Sviridov
authors.forename: N
authors.initials: N
authors.lastname: Fidge
authors.forename: V
authors.initials: V
authors.lastname: Repin
authors.forename: V
authors.initials: V
authors.lastname: Smirnov
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008148:Lovastatin / Q000494:pharmacology*; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008075:Lipoproteins, HDL; D002784:Cholesterol; D008148:Lovastatin