Slow gastric emptying induced by high fat content of meal accelerated by cisapride administered rectally.
The evaluation of agents potentially accelerating gastric emptying in gastric stasis syndromes is time-consuming. Since a previous study showed that emptying is slowed after antecedent fat ingestion and intravenous cisapride abolishes this effect, we investigated whether emptying delayed by fat incorporated into a meal is reversed by cisapride and thus could serve as a model for such evaluations. Twelve healthy males received, under double-blind conditions, 30 mg cisapride rectally or placebo, and 3 hr thereafter a semisolid meal of low (9.2 g) or high (37.9 g) fat content. The sequence of combinations placebo/low-fat meal, placebo/high-fat meal, and cisapride/high-fat meal was randomized. Gastric emptying and antral motility were recorded scintigraphically. After placebo/high-fat, emptying was significantly slower (P less than 0.05) than after placebo/low-fat. After cisapride/high-fat, emptying was significantly faster (P less than 0.01) than after placebo/high-fat and similar to that after placebo/low-fat. Antral motility was little affected. The slow emptying of a high-fat meal thus seems a suitable model for the evaluation of prokinetic drug effects.
Stacher
G
G
Department of Psychiatry, Ludwig Boltzmann Institute of Nuclear Medicine, Vienna, Austria.
Granser
G V
GV
Bergmann
H
H
Kugi
A
A
Stacher-Janotta
G
G
Höbart
J
J
D000285:Administration, Rectal; D000328:Adult; D020117:Cisapride; D004041:Dietary Fats / Q000008:administration & dosage*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005746:Gastric Emptying / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D008297:Male; D010880:Piperidines / Q000008:administration & dosage* / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D013268:Stimulation, Chemical
D004041:Dietary Fats; D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride