[Practical approach to the discovery of serum markers for infection by hepatitis B virus (HBs antigen or anti HBc antibody). Hypertransaminasemia or the two anomalies in a blood donor].
By now in France HBV seric markers (Ag HBs and Ac HBc) and transaminases level (ALT) screenings are compulsory by law in blood donors. People whose blood donation is discarded should be informed. A clinical, epidemiological and virological survey of such donors is required to differentiate healthy Ag HBs carriers and patients suffering from hepatitis B (who may eventually be treated). Similar guidelines may be recommended for the blood donors presenting high transaminases level without HBV seric markers in order to find a cause for such impaired biochemical tests: overweight, alcohol, drug consumption, auto-immune liver disease, genetic disorder, Non-A, Non-B, Non-C hepatitis....
Trepo
C
C
Service d'hépato-gastroentérologie, Hôpital Hôtel-Dieu, Lyon.
Opolon
P
P
Janot
C
C
Boudart
D
D
Cotte
C
C
Courouce
A M
AM
Elghouzzi
M H
MH
Jullien
A M
AM
Lemaire
J M
JM
Maisonneuve
P
P
D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001782:Blood Donors; D007722:Health Knowledge, Attitudes, Practice; D006505:Hepatitis / Q000175:diagnosis; D006508:Hepatitis Antibodies / Q000032:analysis*; D006509:Hepatitis B / Q000175:diagnosis*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006526:Hepatitis C / Q000175:diagnosis; D006801:Humans; D010353:Patient Education as Topic; D012698:Serologic Tests
D006508:Hepatitis Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Attitude pratique devant la découverte de marqueurs sériques d'infection par le virus de l'hépatite B (antigène HBs et/ou anticorps anti-HBc). Une hypertransaminasémie ou les deux anomalies chez un donneur de sang.