Cigarette smoking and the risk of colorectal adenoma in men.
We evaluated the effect of smoking on the risk of developing colorectal adenoma in men. The data were obtained in a case-control study of 103 men with colorectal biopsy-proven adenoma (cases) and 108 men with normal colonoscopy findings (controls). As compared with men who had never smoked, the estimated relative risk of adenoma increased with the pack-year smoking number, the average number of cigarettes per day, and the total years smoked. The estimated overall relative risk was 2.2 (95% confidence interval, 1.1 to 4.3). Adjustment for age did not alter these results. The data suggest that smokers may have a higher risk of developing colorectal adenoma than non-smokers. If these results are confirmed, they might be of direct importance for public health, since adenomas are precursors of colorectal cancer.
Monnet
E
E
Dept. of Public Health, Jean Minjoz Regional Hospital, Besancon, France.
Allemand
H
H
Farina
H
H
Carayon
P
P
D000236:Adenoma / Q000209:etiology*; D001706:Biopsy; D016022:Case-Control Studies; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000209:etiology*; D006801:Humans; D008297:Male; D012907:Smoking / Q000009:adverse effects*