title: Low activity sn-glycerol-3-phosphate dehydrogenase variants in natural populations of Drosophila melanogaster.
abstract: Eleven Australian natural populations of Drosophila melanogaster were screened by electrophoresis for evidence of null and/or low activity variants at the Gdph locus. Of 5018 alleles investigated, 57 had markedly lower GDPH activity, as judged by their heterozygous phenotypes, than control alleles. GPDH assays of 13 of these variant alleles showed that whilst they were heterogeneous in their properties and included electrophoretic variants and two categories of low-activity variant, there were no true null alleles. The most common low-activity variants exhibited dominance for GPDH activity in heterozygotes with normal alleles, and were shown to share this property with an allele previously isolated from a London (UK) population (Langley et al., 1981).
authors.affiliation: Molecular and Population Genetics Group, Research School of Biological Sciences, Australian National University, Canberra City, ACT.
authors.forename: J B
authors.initials: JB
authors.lastname: Gibson
authors.forename: A
authors.initials: A
authors.lastname: Cao
authors.forename: J
authors.initials: J
authors.lastname: Symonds
authors.forename: D
authors.initials: D
authors.lastname: Reed
mesh_terms: D000483:Alleles; D000818:Animals; D001315:Australia; D016009:Chi-Square Distribution; D004331:Drosophila melanogaster / Q000201:enzymology*; D004588:Electrophoresis, Cellulose Acetate; D005060:Europe; D005787:Gene Frequency; D014644:Genetic Variation; D005993:Glycerolphosphate Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D009656:North America
chemical_list: D005993:Glycerolphosphate Dehydrogenase