title: Laminin A-related domains in crb protein of Drosophila and their possible role in epithelial polarization.
abstract: It is shown that four domains of the integral membrane protein crb of Drosophila are homologous with five C-terminal domains of the laminin A chain and merosin. Since the latter domains of laminin A have been implicated in determining epithelial polarity, the homology may suggest a similar function for these domains of crb. Such a function would be consistent with the known importance of crb for organization of epithelia in Drosophila.
authors.affiliation: Institute of Enzymology, Hungarian Academy of Sciences, Budapest.
authors.forename: L
authors.initials: L
authors.lastname: Patthy
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004330:Drosophila; D029721:Drosophila Proteins; D004848:Epithelium / Q000502:physiology*; D007797:Laminin / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry* / Q000502:physiology; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid
chemical_list: D029721:Drosophila Proteins; D007797:Laminin; D008565:Membrane Proteins; C064360:crb protein, Drosophila