title: Organic anion transport study in mutant rats with autosomal recessive conjugated hyperbilirubinemia.
abstract: The EHBR is a mutant rat strain with congenital conjugated hyperbilirubinemia bred from a Sprague-Dawley rat. Transport of conjugated bilirubin, indocyanine green, and tetrabromosulfophtalein from liver to bile is severely impaired in these rats. Serum bilirubin amounts to 6.0 +/- 0.05 mg/dl (n = 4) in adult rats, with 97% conjugates. The bile flow is reduced to about 65% of the control group, whereas total bile acid in 10-min bile samples is similar. Liver histology of 10 week-old rats revealed neither intracellular pigmentation nor architectural abnormalities.
authors.affiliation: Third Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kurisu
authors.forename: K
authors.initials: K
authors.lastname: Kamisaka
authors.forename: T
authors.initials: T
authors.lastname: Koyo
authors.forename: S
authors.initials: S
authors.lastname: Yamasuge
authors.forename: H
authors.initials: H
authors.lastname: Igarashi
authors.forename: H
authors.initials: H
authors.lastname: Maezawa
authors.forename: T
authors.initials: T
authors.lastname: Uesugi
authors.forename: O
authors.initials: O
authors.lastname: Tagaya
mesh_terms: D000818:Animals; D001646:Bile / Q000737:chemistry; D001647:Bile Acids and Salts / Q000032:analysis; D001663:Bilirubin / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D006933:Hyperbilirubinemia, Hereditary / Q000378:metabolism*; D007208:Indocyanine Green / Q000493:pharmacokinetics; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D013448:Sulfobromophthalein / Q000493:pharmacokinetics
chemical_list: D001647:Bile Acids and Salts; D013448:Sulfobromophthalein; C016266:bilirubin glucuronate; D007208:Indocyanine Green; D001663:Bilirubin