title: Expression of shared idiotypes in chronic lymphocytic leukemia and small lymphocytic lymphoma.
abstract: The expression of shared idiotypes (Slds) has been studied on malignant CD5+B cells from patients with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) using a panel of 37 murine monoclonal antibodies previously demonstrated to be reactive with Slds derived from follicular B-cell lymphomas. Thirteen anti-Slds identified tumor cells from 31 of 105 (30%) CLL patients and 4 of 6 SLL patients. In comparison, the same panel of anti-Slds is reactive with 33% of follicular and diffuse B-cell lymphomas. Ten of these anti-Slds reacted with CLL cases at similar frequencies to that of the B-cell lymphomas. Two anti-Slds, which are known to react with autoantibodies, were significantly more prevalent in CLL than in B-cell lymphomas. These data confirm the presence of Slds in CLL and provide further evidence of an association between CLL and autoimmunity. The identification of a panel of antibodies reactive with a significant number of CLL and SLL patients will facilitate the application of anti-idiotype antibody therapy in these diseases.
authors.affiliation: UCSD Cancer Center.
authors.forename: E M
authors.initials: EM
authors.lastname: Swisher
authors.forename: D L
authors.initials: DL
authors.lastname: Shawler
authors.forename: H A
authors.initials: HA
authors.lastname: Collins
authors.forename: A
authors.initials: A
authors.lastname: Bustria
authors.forename: S
authors.initials: S
authors.lastname: Hart
authors.forename: C
authors.initials: C
authors.lastname: Bloomfield
authors.forename: R A
authors.initials: RA
authors.lastname: Miller
authors.forename: I
authors.initials: I
authors.lastname: Royston
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D001324:Autoantigens / Q000032:analysis / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D005434:Flow Cytometry; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D007142:Immunoglobulin gamma-Chains / Q000032:analysis / Q000276:immunology; D007145:Immunoglobulin kappa-Chains / Q000032:analysis / Q000276:immunology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D008224:Lymphoma, Follicular / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D001324:Autoantigens; D007130:Immunoglobulin Idiotypes; D007142:Immunoglobulin gamma-Chains; D007145:Immunoglobulin kappa-Chains