title: Amplification of the c-erbB oncogene is associated with malignancy in primary tumours of neuroepithelial tissue.
abstract: In various primary brain tumours of neuroepithelial tissue recombinant DNA techniques were used to demonstrate changes of the epidermal growth factor receptor gene, which is homologous to the c-erbB oncogene. Twenty-one of 40 grade III/IV tumours, but only 1 of 16 grade I/II tumours were found to contain amplified and/or rearranged c-erbB sequences. This highly significant difference suggest that c-erbB amplification, rearrangement, or both, are important steps in malignant transformation in a subset of patients with neuroepithelial tumours.
authors.affiliation: Neurologische Universitätsklinik, Göttingen, Federal Republic of Germany.
authors.forename: U
authors.initials: U
authors.lastname: Diedrich
authors.forename: S
authors.initials: S
authors.lastname: Soja
authors.forename: J
authors.initials: J
authors.lastname: Behnke
authors.forename: B
authors.initials: B
authors.lastname: Zoll
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis; D066246:ErbB Receptors / Q000235:genetics; D005784:Gene Amplification / Q000235:genetics*; D006801:Humans; D009857:Oncogenes / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D011518:Proto-Oncogene Proteins; D066246:ErbB Receptors