[Participation of 5-HT 1A receptors in the decrease by serotonin of activation of locus coeruleus neurons by glutamate].
The serotonin-induced decrease of glutamate-evoked activation of noradrenergic locus coeruleus neurons is mimicked by agonists of 5-HT 1 and 1A but not by 5-HT 1B or by 5-HT 2 agonists. Moreover, this effect is reversed by a broad-spectrum 5-HT antagonist but not by a 5-HT 2 antagonist, indicating that this effect is mediated primarily through 5-HT 1A receptors.
Charlety
P J
PJ
I.N.S.E.R.M., U 171 et C.N.R.S., U.A. 1195, Centre hospitalier Lyon-Sud, Pierre-Bénite.
Aston-Jones
G
G
Akaoka
H
H
Buda
M
M
Chouvet
G
G
D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates / Q000494:pharmacology; D008125:Locus Coeruleus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009474:Neurons / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*
D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates; D011985:Receptors, Serotonin; D012701:Serotonin
Participation des récepteurs 5-HT 1A dans la diminution par la sérotonine de l'excitation des neurones du locus coeruleus évoquée par le glutamate.