Effect of single doses of cisapride and ranitidine administered simultaneously on plasma concentrations of cisapride and ranitidine.
We have studied in 12 volunteers the effect of single doses of cisapride and ranitidine, administered simultaneously, on plasma concentrations of cisapride and ranitidine. Median maximum plasma concentration of ranitidine was achieved 1 h earlier when ranitidine was taken with cisapride compared with ranitidine alone (P = 0.012). There was a 24% decrease in plasma ranitidine AUC8h when ranitidine was taken with cisapride compared with ranitidine alone (P less than 0.005). Ranitidine had no effect on absorption of cisapride.
Rowbotham
D J
DJ
University Department of Anaesthesia, Leicester Royal Infirmary.
Milligan
K
K
McHugh
P
P
D000328:Adult; D020117:Cisapride; D004341:Drug Evaluation; D004347:Drug Interactions; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D011899:Ranitidine / Q000097:blood / Q000493:pharmacokinetics*; D012702:Serotonin Antagonists / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology
D010880:Piperidines; D012702:Serotonin Antagonists; D011899:Ranitidine; D020117:Cisapride