Hirudin in disseminated intravascular coagulation.
Various reactions of disseminated intravascular coagulation (DIC) were experimentally induced by infusion of thrombokinase in rats, by administration of endotoxin in rabbits and pigs and by infusion of adrenaline and thrombin in dogs. Low plasma concentrations of recombinant hirudin (r-hirudin; 20-200 ng/ml) were sufficient for the inhibition of the different triggering mechanisms. The studies on the pharmacological profile of r-hirudin in DIC therapy confirm the efficacy of this specific tight-binding thrombin inhibitor.
Nowak
G
G
Institute of Pharmacology and Toxicology, Medical Academy Erfurt, FRG.
Markwardt
F
F
D000818:Animals; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000517:prevention & control*; D004285:Dogs; D004731:Endotoxins / Q000037:antagonists & inhibitors / Q000633:toxicity; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000633:toxicity; D015951:Factor Xa / Q000633:toxicity; D065427:Factor Xa Inhibitors; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D024764:Hirudin Therapy; D006629:Hirudins / Q000031:analogs & derivatives* / Q000494:pharmacology; D008050:Lipid A / Q000037:antagonists & inhibitors / Q000633:toxicity; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D013045:Species Specificity; D013552:Swine; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000633:toxicity; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000139:chemically induced / Q000188:drug therapy; D014781:Viscera / Q000098:blood supply
D004731:Endotoxins; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents; D006629:Hirudins; D008050:Lipid A; D011994:Recombinant Proteins; D013917:Thrombin; D015951:Factor Xa; C060225:desirudin; D004837:Epinephrine