2,4-Dichlorophenoxyacetic acid effects on polyamine biosynthesis.
2,4-Dichlorophenoxyacetic acid (2,4-D) is a herbicide extensively used in agriculture. It was considered of interest to study its toxicity on animal cells. We had previously determined that 1 mM 2,4-D can inhibit cell growth, DNA and protein synthesis of cultured Chinese hamster ovary cells (CHO) with cell accumulation in the G1/S interphase of the cell cycle. The present work examined the effects of 2,4-D on polyamine biosynthesis. The results suggest some possible mechanism of the herbicide's toxic effects on animal cells.
Rivarola
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V
Departamento Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Córdoba, Argentina.
Balegno
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H
D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003470:Culture Media; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D009955:Ornithine Decarboxylase / Q000032:analysis; D011073:Polyamines / Q000378:metabolism*; D014176:Protein Biosynthesis; D011506:Proteins / Q000187:drug effects; D011700:Putrescine / Q000096:biosynthesis / Q000494:pharmacology; D013095:Spermidine / Q000096:biosynthesis / Q000494:pharmacology; D011436:Spermidine Synthase / Q000032:analysis; D013096:Spermine / Q000096:biosynthesis / Q000494:pharmacology; D013097:Spermine Synthase / Q000032:analysis
D003470:Culture Media; D011073:Polyamines; D011506:Proteins; D015084:2,4-Dichlorophenoxyacetic Acid; D013096:Spermine; D004247:DNA; D011436:Spermidine Synthase; D013097:Spermine Synthase; D009955:Ornithine Decarboxylase; D013095:Spermidine; D011700:Putrescine