Effect of ethanol on the induction of lung tumours by ethyl carbamate in mice.
Groups of 25 female NMRI-mice received daily doses of 0, 18, 36, 90, or 180 mg ethyl carbamate/kg body wt either in water or in 20% ethanol by gavage for 8 weeks. Another 8 weeks later, the animals were sacrificed and lung adenomas were counted. Ethyl carbamate was found to increase the number of lung adenomas per mouse dose-dependently in all dose groups. No significant differences, however, were observed between groups receiving ethyl carbamate in water or in 20% ethanol. Thus, ethanol had no effect on ethyl carbamate induced tumourigenesis.
Altmann
H J
HJ
Abteilung Toxikologie der Lebensmittel und Bedarfsgegenstände, Max-von-Pettenkofer-Institut, Berlin, Germany.
Dusemund
B
B
Goll
M
M
Grunow
W
W
D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D051379:Mice; D014520:Urethane / Q000037:antagonists & inhibitors / Q000633:toxicity*
D014520:Urethane; D000431:Ethanol