Influence of the fluoride ion in the stability of bone hydroxyapatite achieved in patients after the fluo-calcic therapy.
It has been proposed that fluoride ion might actively enter into the basic structural framework of the bone, within its main constituent, the hydroxyapatite (HA), by substituting systematically the OH- ion in the crystal chemical formula Ca5[(PO4)3OH]. Accurate compositional studies have become necessary in order to explain an eventual stabilizing effect. Loss in weight (TG) and chemical reaction (DTG) while varying the temperature have been carried out for the first time on specimens under normal conditions and after fluo-calcic treatment, in parallel with accurate chemical compositional determinations by atomic absorption analysis. Our investigation shows that the new structure present after treatment is mechanically stable and proves more resistant to osteolytic processes.
Mongiorgi
R
R
Department of Mineralogical Sciences, University of Bologna.
Bertocchi
G
G
Gnudi
S
S
Maggi
G
G
Moroni
A
A
Coppola
G
G
Riva di Sanseverino
L
L
D001859:Bone Neoplasms / Q000188:drug therapy*; D001842:Bone and Bones / Q000648:ultrastructure; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D009101:Multiple Myeloma / Q000188:drug therapy*; D012969:Sodium Fluoride / Q000627:therapeutic use*
D012969:Sodium Fluoride; D005459:Fluorides