Sequential renal alterations in septic shock in the primate.
This is a descriptive sequential study of the response of the baboon to LD100 Escherichia coli. The response was found to consist of three stages based on electron microscopic, physiologic, and clinical laboratory data. This study associates the inflammatory, coagulant, and cell injury (stage 1-3) responses with markers of activation of inflammatory cells (tumor necrosis factor) and of the vascular endothelium (tissue plasminogen activator). This work also shows that in contrast to the underlying parenchymal cells of the organ, the vascular endothelium remains intact throughout the response to LD100 E. coli. The possible role of the vascular endothelium in mediation of events at both its luminal (blood) and antiluminal (parenchymal) surfaces is discussed.
Voss
B L
BL
Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
De Bault
L E
LE
Blick
K E
KE
Chang
A C
AC
Stiers
D L
DL
Hinshaw
L B
LB
Taylor
F B
FB
D000818:Animals; D002196:Capillaries / Q000473:pathology; D004487:Edema / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D004927:Escherichia coli Infections; D007668:Kidney / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D007684:Kidney Tubules / Q000473:pathology; D007962:Leukocytes / Q000473:pathology; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009336:Necrosis; D010215:Papio; D012772:Shock, Septic / Q000473:pathology* / Q000503:physiopathology; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D014409:Tumor Necrosis Factor-alpha; D010959:Tissue Plasminogen Activator