[Importance of studying deficiencies of IgG subclasses (IgG2 and IgG4) in immuno-allergologic practice].
Levels of the sub-classes of immunoglobulins IgG2 and IgG4 have been established by radial diffusion with monoclonal antibodies in 150 subjects. 49 (42 adults and 7 children) showed either a low level of IgG2 (less than 0.42 g/l n = 11) or a reduced level of IgG4 (less than 0.05 g/l n = 38). A single patient had a double deficit, 38 subjects had a superinfection of which 17 had a severe form and in 77% of these cases a level of IgG4 of less than 0.05 g/l.
Favennec
F
F
Sce d'ophtalmologie, Hôpital de Ponchaillou, Rennes.
Pinon
C
C
Sainte-Laudy
J
J
Oussa
G
G
Toulemont
P J
PJ
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications / Q000175:diagnosis*; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D017099:IgG Deficiency; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D008297:Male; D008875:Middle Aged; D008925:Mites; D011058:Pollen; D012130:Respiratory Hypersensitivity / Q000209:etiology / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000209:etiology; D014581:Urticaria / Q000209:etiology / Q000276:immunology
D007074:Immunoglobulin G
Intérêt de la recherche d'un déficit en sous-classes d'IgG (IgG2 et IgG4) en pratique immuno-allergologique.