title: The myogenic contribution to coronary autoregulation.
abstract: It seems now, mainly from the results of the experiments carried out in the Department of Human Anatomy and Physiology of the University of Turin, Italy, that there is an active myogenic response in the coronary vessels. In response to changes in the transmural pressure, both increases and decreases, in the coronary vessels transient contractions and relaxations (respectively) of the smooth muscle wall can be demonstrated. Although this suggested mechanism can not be fully integrated into a hypothesis explaining autoregulation of blood flow in the coronary vessels it does seem a strong possibility that it takes part; but further investigation will be necessary to clarify all aspects of this kind of regulation.
authors.affiliation: Department of Biomedical Sciences (Physiology), King's College London, University of London, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Linden
authors.forename: G
authors.initials: G
authors.lastname: Losano
mesh_terms: D000818:Animals; D001794:Blood Pressure; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000502:physiology*; D006470:Hemorrhage / Q000503:physiopathology; D006487:Hemostasis / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology