Amyloid-related proteins and nerve growth factor in Alzheimer's disease and animal models.
Alzheimer's disease (AD), the most common cause of dementia in adult life, is characterized by the deposition of amyloid in brain parenchyma and the degeneration of specific populations of nerve cells, including cholinergic neurons in the basal forebrain. In this review, we first outline studies of cellular and molecular events that lead to age-associated deposition of amyloid in the brains of nonhuman primates and then describe investigations of the effect of treatment with nerve growth factor (NGF) on experimentally induced abnormalities in cholinergic neurons of the basal forebrain. These studies of amyloidogenesis and the efficacy of trophic factors on specific groups of experimentally damaged neurons provide information about issues central to understanding the pathogenesis and treatment of human degenerative diseases, including AD.
Price
D L
DL
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2181.
Koliatsos
V E
VE
Sisodia
S S
SS
Koo
E H
EH
Martin
L J
LJ
Walker
L C
LC
Appelgate
M D
MD
Cork
L C
LC
D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism*; D000682:Amyloid / Q000032:analysis*; D016564:Amyloid beta-Protein Precursor / Q000032:analysis*; D000686:Amyloidosis / Q000378:metabolism*; D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects; D004195:Disease Models, Animal; D009414:Nerve Growth Factors / Q000494:pharmacology* / Q000627:therapeutic use
D000682:Amyloid; D016564:Amyloid beta-Protein Precursor; D009414:Nerve Growth Factors