title: [Acidic copper-containing proteins--an intermediate link to the electron transfer stage from cytochrome b-561 to dopamine-beta-monooxygenase].
abstract: The interaction of acidic copper-containing protein from the membranes of chromaffin granules has been investigated with cytochrome b-561 and dopamine-beta-monooxygenase from the same source. By the use of spectral and polarographic measurements it was demonstrated that the acidic copper-containing protein acts as an electron acceptor for cytochrome b-561 and as electron donor in the reactions, catalyzed by dopamine-beta-monooxygenase. According to the data obtained the possible function of the acidic copper-containing protein in vivo on the area of electron transfer chain between cytochrome b-561 and dopamine-beta-monooxygenase are discussed. The activation or inhibition of the electron transfer reactions by a variety of phospholipids, analogs of membrane lipids of chromaffin granules has been established. The experiments were performed in a model systems by the use of highly purified preparations of proteins and bilamellar liposomes and micelles, prepared from the corresponding phospholipids.
authors.forename: L L
authors.initials: LL
authors.lastname: Oganesian
authors.forename: A S
authors.initials: AS
authors.lastname: Boiadzhian
authors.forename: S A
authors.initials: SA
authors.lastname: Petrosian
authors.forename: K G
authors.initials: KG
authors.lastname: Karagezian
mesh_terms: D000818:Animals; D002417:Cattle; D002837:Chromaffin Granules / Q000201:enzymology; D003573:Cytochrome b Group / Q000378:metabolism*; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism*; D004579:Electron Transport; D007700:Kinetics; D008565:Membrane Proteins / Q000378:metabolism*; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000378:metabolism
chemical_list: D003573:Cytochrome b Group; D008565:Membrane Proteins; D010743:Phospholipids; C023646:cytochrome b561; D004299:Dopamine beta-Hydroxylase
vernacular_title: Kislyĭ med'soderzhashchiĭ belok--promezhutochnoe zveno na stadii perenosa élektronov ot tsitokhroma b-561 k dofamina-beta-monooksigenaze.