title: Complement activation during bypass in acquired C1 esterase inhibitor deficiency.
abstract: Serial complement estimations during cardiopulmonary bypass are reported in a patient with acquired C1 esterase inhibitor deficiency. Although the extent of classic and alternative pathway activation appeared appropriate, exaggerated common pathway activation with massive increase in the C3d:C3 ratio occurred. A fatal hemostatic disorder, pulmonary edema, and circulatory collapse ensued despite prophylaxis and therapy.
authors.affiliation: Brompton Hospital, London, United Kingdom.
authors.forename: R S
authors.initials: RS
authors.lastname: Bonser
authors.forename: J
authors.initials: J
authors.lastname: Dave
authors.forename: J
authors.initials: J
authors.lastname: Morgan
authors.forename: C
authors.initials: C
authors.lastname: Morgan
authors.forename: E
authors.initials: E
authors.lastname: Davies
authors.forename: P
authors.initials: P
authors.lastname: Taylor
authors.forename: H
authors.initials: H
authors.lastname: Gaya
authors.forename: L
authors.initials: L
authors.lastname: John
authors.forename: M
authors.initials: M
authors.lastname: Paneth
authors.forename: D
authors.initials: D
authors.lastname: Vergani
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D003167:Complement Activation / Q000276:immunology*; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency*; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D012307:Risk Factors
chemical_list: D003174:Complement C1 Inactivator Proteins