title: Caval thrombolysis in neonates using low doses of recombinant human tissue-type plasminogen activator.
abstract: Four neonates suffered caval thrombosis secondary to indwelling central catheters. Dissolution of thrombus with recombinant tissue plasminogen activator (rt-PA) as a low-dose infusion (0.05 mg/kg/hr) directly into thrombus was successful in three patients. rt-PA was ceased after three days in the fourth patient because of catheter malposition. Thrombolysis was achieved between four and ten days. Rethrombosis occurred in one patient despite heparin prophylaxis. Plasminogen activator infusions were titrated to maintain fibrinogen levels above 100 mg/dl. One neonate suffered an intracranial haemorrhage. Regional rt-PA is an alternative to thrombectomy in critically ill neonates.
authors.affiliation: Department of Intensive Care, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: B J
authors.initials: BJ
authors.lastname: Anderson
authors.forename: S R
authors.initials: SR
authors.lastname: Keeley
authors.forename: N D
authors.initials: ND
authors.lastname: Johnson
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy; D011994:Recombinant Proteins; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D014682:Vena Cava, Inferior; D014683:Vena Cava, Superior
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator