Combination effect of recombinant human interleukin 1 alpha with antitumor drugs on syngeneic tumors in mice.
To investigate the combination effects of recombinant human interleukin 1 alpha (rHu IL-1 alpha) and antitumor drugs, groups of 7 mice bearing syngeneic tumors (Meth A sarcoma in BALB/c mice and colon 26 adenocarcinoma in BALB/c x DBA/2 F1 mice) were treated i.v. with the antitumor drugs according to the early (once daily on days 1, 4, 7, 10, and 13) and/or late (once daily on days 7, 10, 13, 16, and 19) medication schedules in combination with rHu IL-1 alpha administered i.m. at various timings (1 day before, concurrently with, and 1 day after every drug administration). Inhibition rates of the antitumor drugs (mitomycin C, doxorubicin, cisplatin, cyclophosphamide, and 5-fluorouracil) for both the murine tumors were more or less raised by coadministration of rHu IL-1 alpha irrespective of medication schedules and combination timings. After both early and late treatments with the optimal combinations of rHu IL-1 alpha (0.1-3 micrograms/mouse) and cisplatin (2-4 mg/kg) and by the late treatment with the optimal combinations of rHu IL-1 alpha (0.3-3 micrograms/mouse) and carboplatin (32 mg/kg) or thiotepa (4 mg/kg), many mice were completely cured of colon 26 adenocarcinoma and survived for more than 90 days. Combined use of rHu IL-1 alpha and antitumor drugs seems to be beneficial in antitumor chemotherapy.
Nakamura
S
S
Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.
Kashimoto
S
S
Kajikawa
F
F
Nakata
K
K
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D007375:Interleukin-1 / Q000008:administration & dosage*; D051379:Mice; D008815:Mice, Inbred Strains; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D009374:Neoplasms, Experimental; D011994:Recombinant Proteins / Q000008:administration & dosage; D016019:Survival Analysis; D013852:Thiotepa / Q000008:administration & dosage
D007375:Interleukin-1; D008937:Mitomycins; D011994:Recombinant Proteins; D016685:Mitomycin; D004317:Doxorubicin; D003520:Cyclophosphamide; D013852:Thiotepa; D016190:Carboplatin; D002945:Cisplatin