Targetted destruction of PC3 mitochondria by ETYA: a 'Trojan horse' membrane-suicide molecule.
The reported incorporation of ETYA in place of arachidonic acid, itself enriched in mitochondria, and the autooxidation of alkyne groups, as indicated by spontaneous chemiluminescence, encompasses several features appropriate for an organelle-specific 'suicide' molecule. In point of fact, ETYA selectively destroys PC3 mitochondria.
Anderson
K M
KM
Department of Medicine, Rush Medical College, Chicago, IL 60612.
Harris
J E
JE
D015117:5,8,11,14-Eicosatetraynoic Acid / Q000494:pharmacology*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D002460:Cell Line; D005609:Free Radicals; D006801:Humans; D008163:Luminescent Measurements; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism
D001095:Arachidonic Acids; D005609:Free Radicals; D015117:5,8,11,14-Eicosatetraynoic Acid; D016718:Arachidonic Acid