Acidotic effect of gaboon viper (Bitis gabonica) venom in the urethane-anaesthetized rat.
1. Intravenous venom (4 mg/kg) caused a non-compensated metabolic acidosis. 2. Bicarbonate concentration, base excess, standard base excess and pH all fell dramatically. 3. A respiratory impairment occurred characterized by pulmonary oedema and a fall in arterial pO2. 4. Acidosis occurred soon after venom when pO2 was still normal, indicating that changes in tissue metabolism contributed to the acidosis independently of reduced oxygen availability.
Gattullo
D
D
Dipartimento di Anatomia e Fisiologia Umana, Università degli studi di Torino, Italy.
Hyslop
S
S
Marsh
N A
NA
Pagliaro
P
P
Vono
P
P
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000138:Acidosis / Q000139:chemically induced*; D000758:Anesthesia; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D004562:Electrocardiography; D004566:Electrodes; D066298:In Vitro Techniques; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014520:Urethane; D014757:Viper Venoms / Q000633:toxicity*
D001639:Bicarbonates; D014757:Viper Venoms; D002245:Carbon Dioxide; D014520:Urethane