title: [Vasculitis with cutaneous necrosis induced by oral contraceptive].
abstract: Multiple ulcerated and necrotic lesions developed in a 29-year-old woman. Response to treatment during the next few months was minimal. The most plausible explanation was drug-induced vasculitis caused by contraceptive pills (Microgynon: levonorgestrel 0.15 mg and ethinyl oestradiol 0.03 mg). The diagnosis of vasculitis was confirmed by histopathological and immunofluorescent studies. Urticarial manifestations had developed into necrotizing inflammation and the lesions only began to heal after discontinuation of the pills. Contraceptive pills are not included among the drugs causing necrotizing vasculitis, and to the best of our knowledge, this is the first report. Although contraceptive pills are commonly implicated in the induction of erythema nodusom or vasculitis, such a severe reaction with necrosis is rare.
authors.affiliation: Dept. of Family Medicine, Soroka Medical Center, Beer Sheba.
authors.forename: B
authors.initials: B
authors.lastname: Mosovich
authors.forename: A
authors.initials: A
authors.lastname: Biton
authors.forename: I
authors.initials: I
authors.lastname: Avinoach
mesh_terms: D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009336:Necrosis; D012867:Skin / Q000473:pathology*; D014657:Vasculitis / Q000139:chemically induced* / Q000473:pathology
chemical_list: D003277:Contraceptives, Oral, Combined