title: Extracellular pH in the brain during ischemia: relationship to the severity of lactic acidosis.
abstract: On the basis of data showing a bimodal distribution of values for extracellular pH (pHe), and a discontinuous delta PCO2/delta lactate relationship, Kraig et al. (1986) proposed that H+ is grossly compartmentalized between neurons and glia in the ischemic brain. We measured delta pHe during ischemia, varying ischemic lactate contents between 9 and 38 mmol kg-1. No bimodal distribution was found, but delta pHe varied linearly with lactate content. Because we have also failed to record a discontinuous delta PCO2/delta lactate relationship, we conclude that major compartmentation of H+ does not occur during ischemia.
authors.affiliation: Laboratory for Experimental Brain Research, University of Lund, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Katsura
authors.forename: A
authors.initials: A
authors.lastname: Ekholm
authors.forename: B
authors.initials: B
authors.lastname: Asplund
authors.forename: B K
authors.initials: BK
authors.lastname: Siesjö
mesh_terms: D000140:Acidosis, Lactic / Q000150:complications / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006943:Hyperglycemia / Q000150:complications / Q000378:metabolism; D002546:Ischemic Attack, Transient / Q000150:complications / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid