C-formylation in the presence of rat brain mitochondria of the 2,3,4,5-tetrahydropyridinium metabolite derived from the psychotomimetic drug phencyclidine.
The 1-(1-phenylcyclohexyl)-2,3,4,5-tetrahydropyridinium metabolite derived from the psychotomimetic agent phencyclidine [1-(1-phenylcyclohexyl)piperidine] is converted to 1-(phenylcyclohexyl)-1,2,3,4-tetrahydropyridine-5-carboxaldehyde in the presence of rat brain and liver mitochondria. The C-5 formylation of synthetic 1-(1-phenylcyclohexyl)-2,3,4,5-tetrahydropyridinium perchlorate by N5-formyltetrahydrofolic acid (folinic acid) suggests that this biotransformation is mediated by a transformylation process involving this N5- or the corresponding N10-formyltetrahydrofolic acid.
Zhao
Z Y
ZY
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Leung
L Y
LY
Trevor
A
A
Castagnoli
N
N
D000818:Animals; D001711:Biotransformation; D001921:Brain / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D010622:Phencyclidine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D010622:Phencyclidine