title: Total pancreatectomy in a case of nesidioblastosis due to persisting hyperinsulinism following subtotal pancreatectomy.
abstract: Hypoglycemia with hyperinsulinism persisted in a newborn weighing 6410 g despite treatment with high doses of diazoxide and glucagon, as well as infusions of glucose and somatostatin. A subtotal pancreatectomy was performed after nesidioblastosis had been diagnosed on the basis of the laboratory findings. Due to the persistence of therapy-resistant hypoglycemia, a total pancreatectomy preserving the duodenum and the bile duct was done 6 weeks later. With insulin and pancreatic enzyme substitution the now 6-year, 9-month-old child has shown normal, age, appropriate development.
authors.affiliation: Department of General Surgery, Kiel, FRG.
authors.forename: P
authors.initials: P
authors.lastname: Dohrmann
authors.forename: W
authors.initials: W
authors.lastname: Mengel
authors.forename: J
authors.initials: J
authors.lastname: Splieth
mesh_terms: D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology* / Q000601:surgery; D007003:Hypoglycemia / Q000209:etiology; D007231:Infant, Newborn; D010179:Pancreas / Q000473:pathology; D010180:Pancreatectomy; D010182:Pancreatic Diseases / Q000150:complications / Q000473:pathology / Q000601:surgery*; D012008:Recurrence