6-Pentadecylsalicylic acid: an antithrombin component isolated from the stem of Rhus semialata var. roxburghii.
Bioassay-directed fractionation of the n-hexane extract of the stem of Rhus semialata Murr. var. roxburghii DC (Anacardiaceae) has led to the isolation of 6-pentadecylsalicylic acid. It showed antithrombin activity at 50 micrograms/ml in the amidolytic method. It also prolonged the clotting time in a dose-dependent manner in the clotting assay of thrombin-fibrinogen interaction.
Kuo
S C
SC
Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taichung, Taiwan.
Teng
C M
CM
Lee
L G
LG
Chiu
T H
TH
Wu
T S
TS
Huang
S C
SC
Wu
J B
JB
Shieh
T Y
TY
Chang
R J
RJ
Chou
T C
TC
D000595:Amino Acid Sequence; D048729:Anacardic Acids; D000818:Animals; D000991:Antithrombins / Q000302:isolation & purification / Q000378:metabolism; D002417:Cattle; D002863:Chromogenic Compounds / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D012459:Salicylates / Q000302:isolation & purification / Q000494:pharmacology*
D048729:Anacardic Acids; D000991:Antithrombins; D002863:Chromogenic Compounds; D012459:Salicylates; C088115:anacardic acid