[Dissociation between peripheral and central components of tolerance to behavior effects of interleukin-1 in rats].
Interleukin-1 (Il-1) is an endogenous pyrogen which is released by accessory immune cells and which has potent neural effects. Rats implanted subcutaneously with an osmotic mini-pump delivering 2 micrograms Il-1 per day rapidly became tolerant to the behavioral and toxic effects of this cytokine. Acute challenge with Il-1 reversed this tolerance when the cytokine was injected intraperitoneally (3 micrograms/rat) but not when it was injected into the lateral cerebral ventricle (3 ng/rat). These results suggest a differential regulation of the peripheral and central receptors mediating the effects of Il-1.
Bluthé
R M
RM
I.N.R.A.-I.N.S.E.R.M. U. n 176, Bordeaux.
Dantzer
R
R
Kelley
K W
KW
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007375:Interleukin-1
Dissociation entre les composantes périphérique et centrale de la tolérance aux effets comportementaux de l'interleukine-1 chez le rat.