[Splenopentin--modulator of immunological and behavioral reactions in secondary immunodeficiency state induced by experimental alcoholism].
Effect of splenopentin on some patterns of immunity was studied in mice with chronic alcoholic intoxication. Splenopentin was administrated into animals once intraperitoneally (250 micrograms/kg). Administration of splenopentin was found to normalize several immunological patterns in animals with chronic alcoholic intoxication: the immune response to the thymus-dependent antigen sheep red blood cells and phagocytic activity of peritoneal macrophages. Also observations over C57B1/6 mice characterized by high level of alcoholic motivation showed that alcohol consumption in mice decreased after administration of splenopentin at a dose of 250 micrograms/kg during two weeks.
Evseev
V A
VA
Institute of Bioactive Substances of GDR Academy of Sciences, Berlin.
Davydova
T V
TV
Fomina
V G
VG
Odariuk
Iu
Iu
Repke
G
G
Oeme
P
P
Forner
K
K
D000437:Alcoholism / Q000188:drug therapy / Q000276:immunology*; D000818:Animals; D001522:Behavior, Animal; D051379:Mice; D008810:Mice, Inbred C57BL; D010446:Peptide Fragments / Q000627:therapeutic use*; D013946:Thymopoietins / Q000627:therapeutic use*
D010446:Peptide Fragments; D013946:Thymopoietins; C041898:splenopentin
Splenopentin--moduliator immunnykh i povedencheskikh reaktsiĭ pri vtorichnom immunodefitsitnom sostoianii, vyzvannom éksperimental'nym alkogolizmom.