[The comparison of drug susceptibility of antituberculous agents against colonizing M. intracellulare and infectious M. intracellulare].
The susceptibility of antituberculous agents against colonized M. intracellulare which were isolated from patients with pulmonary disease and infectious M. intracellulare (pathogens) isolated from atypical mycobacterial culture was investigated. Aminoglycosides were more potent against colonized organisms than against pathogens. Isoniazid, ethambutol and rifampicin showed less potent antimicrobial activity against both colonized organism and pathogens as compared to aminoglycosides. On the contrary susceptibility of cycloserine against colonized organisms was as potent as against pathogens.
Maesaki
S
S
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Higashiyama
Y
Y
Mitsutake
K
K
Matsuda
H
H
Yamada
H
H
Sugiyama
H
H
Kaku
M
M
Koga
H
H
Kohno
S
S
Hara
K
K
D000368:Aged; D000995:Antitubercular Agents / Q000494:pharmacology*; D015342:DNA Probes; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015269:Mycobacterium avium Complex / Q000187:drug effects* / Q000472:pathogenicity
D000995:Antitubercular Agents; D015342:DNA Probes