title: [Clinical evaluation of terodiline hydrochloride in patients with urinary frequency or incontinence].
abstract: A clinical trial with the collaboration of 15 department of urology was performed to determine the usefulness of terodiline hydrochloride in 99 patients whose chief complaints were of pollakisuria or incontinence due to neurogenic bladder, psychogenic disease or chronic cystitis. The patients were orally given 24 mg once daily for 4 weeks. The final global improvement rate was 88.5% and the effective rates on subjective symptoms were; 66.2% for diurnal urinary frequency, 68.0% for nocturnal urinary frequency, 68.8% for urinary incontinence and 78.3% for nocturnal enuresis. Even for the cases having mild bladder outlet obstructive disease, the clinical effective rates were good. Mild side effects were observed in 10 patients, which were dry mouth and others. The results obtained from this trial suggest that terodiline hydrochloride may be useful for the treatment of urinary frequency and incontinence caused by detrusor instability.
authors.affiliation: Department of Urology, Kobe University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Yasuno
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
authors.forename: S
authors.initials: S
authors.lastname: Arakawa
authors.forename: O
authors.initials: O
authors.lastname: Matsumoto
authors.forename: S
authors.initials: S
authors.lastname: Kamidono
authors.forename: N
authors.initials: N
authors.lastname: Kataoka
authors.forename: M
authors.initials: M
authors.lastname: Matsushita
authors.forename: Y
authors.initials: Y
authors.lastname: Inaba
authors.forename: K
authors.initials: K
authors.lastname: Umezu
authors.forename: M
authors.initials: M
authors.lastname: Yamashita
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002082:Butylamines / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014549:Urinary Incontinence / Q000188:drug therapy; D014555:Urination Disorders / Q000188:drug therapy*
chemical_list: D002082:Butylamines; C010637:terodiline