title: A practical guide to nitrate use.
abstract: Nitrate preparations are useful in the treatment of acute and chronic angina, acute and chronic congestive heart failure, and acute myocardial infarction. Development of tolerance is best managed by providing a nitrate-free interval, thus avoiding continuous drug levels. This interval probably should be 10 to 12 hours with use of a transdermal patch. Nitrate treatment of the elderly may require lower doses to avoid hypotension.
authors.affiliation: Parkview Internal Medicine Associates, St. Paul.
authors.forename: K A
authors.initials: KA
authors.lastname: Anderson
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy; D005996:Nitroglycerin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011654:Pulmonary Edema / Q000188:drug therapy
chemical_list: D005996:Nitroglycerin; D007548:Isosorbide Dinitrate