title: Myelodysplastic syndrome and acquired factor VIII inhibitor with severe subcutaneous haemorrhage.
abstract: A case of acquired haemophilia A presenting with extensive spontaneous bruising and anaemia is reported. The anaemia was due to myelodysplastic syndrome (FAB: refractory anaemia with ringed sideroblasts). A factor-VII:C-specific inhibitor was also found. Prednisone and pyridoxine were given, and the inhibitor became undetectable after 4 weeks of therapy, but the abnormal ringed sideroblasts still persisted on repeated bone marrow biopsy.
authors.affiliation: Department of Pathology, Queen Mary Hospital, University of Hong Kong.
authors.forename: C K
authors.initials: CK
authors.lastname: Lin
authors.forename: R
authors.initials: R
authors.lastname: Liang
authors.forename: H W
authors.initials: HW
authors.lastname: Liu
authors.forename: P W
authors.initials: PW
authors.lastname: Tse
authors.forename: G T
authors.initials: GT
authors.lastname: Chan
mesh_terms: D000368:Aged; D000756:Anemia, Sideroblastic / Q000209:etiology / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D005260:Female; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000150:complications*; D011241:Prednisone / Q000627:therapeutic use; D011736:Pyridoxine / Q000627:therapeutic use
chemical_list: D005169:Factor VIII; D011736:Pyridoxine; D011241:Prednisone