[The role of the ADP/ATP-antiporter in the inhibition of nonspecific permeability of the inner mitochondrial membrane by cyclosporin A].
The effect of the conformational state of the ADP/ATP-antiporter on the efficiency of inhibition by cyclosporine A of the Ca(2+)-induced increase of nonspecific permeability of the inner mitochondrial membrane was under study. It was found that the ADP/ATP-antiporter inhibitor carboxyatractyloside is able to reverse the cyclosporine A-induced inhibition of this nonspecific permeability. The effect of carbocyatractyloside is manifested only in mitochondria depleted of adenine nucleotides. The bifunctional SH-reagent phenylarsine oxide is also able to reverse the cyclosporine A effect. The data obtained testify to the fact that inhibition by cyclosporine A of nonspecific permeability is due to its effect on the conformational state of the ADP/ATP-antiporter.
Novgorodov
S A
SA
Gudz'
T I
TI
Kushnareva
Iu E
IuE
Zorov
D B
DB
Kudriashov
Iu B
IuB
D001152:Arsenicals / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D003524:Cyclosporins / Q000494:pharmacology*; D005033:Ethylmaleimide / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects / Q000502:physiology; D008634:Mersalyl / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects*; D000226:Mitochondrial ADP, ATP Translocases / Q000502:physiology*; D010539:Permeability / Q000187:drug effects
D001152:Arsenicals; D003524:Cyclosporins; C029341:oxophenylarsine; D008634:Mersalyl; D000226:Mitochondrial ADP, ATP Translocases; D005033:Ethylmaleimide; D002118:Calcium
Rol' ADP/ATP-antiportera v podavlenii tsiklosporinom A nespetsificheskoĭ pronitsaemosti vnutrenneĭ membrany mitokhondrii.