title: Treatment of fetal supraventricular tachycardia with flecainide acetate after digoxin failure.
abstract: Transplacentally administered digoxin is the drug of choice for the treatment of fetal supraventricular tachycardia. We describe a case of fetal supraventricular tachycardia associated with fetal hydrops that did not respond to digoxin treatment because of a lack of transplacental passage. In contrast, flecainide acetate crossed the placenta and cured the fetus. The clinical implications of this new treatment are discussed.
authors.affiliation: Department of Obstetrics and Gynecology, York Hospital, PA 17405.
authors.forename: A D
authors.initials: AD
authors.lastname: Kofinas
authors.forename: N V
authors.initials: NV
authors.lastname: Simon
authors.forename: H
authors.initials: H
authors.lastname: Sagel
authors.forename: E
authors.initials: E
authors.lastname: Lyttle
authors.forename: N
authors.initials: N
authors.lastname: Smith
authors.forename: K
authors.initials: K
authors.lastname: King
mesh_terms: D000328:Adult; D004077:Digoxin / Q000627:therapeutic use*; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy*; D005424:Flecainide / Q000627:therapeutic use*; D006801:Humans; D011247:Pregnancy; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*
chemical_list: D004077:Digoxin; D005424:Flecainide