Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm.
Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.
Giwercman
B
B
Institute of Medical Microbiology, University of Copenhagen, Denmark.
Jensen
E T
ET
Høiby
N
N
Kharazmi
A
A
Costerton
J W
JW
D003470:Culture Media; D004790:Enzyme Induction / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D015378:Imipenem / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010878:Piperacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000201:enzymology*; D001618:beta-Lactamases / Q000096:biosynthesis*
D003470:Culture Media; D015378:Imipenem; D001618:beta-Lactamases; D010878:Piperacillin