Differential spatial and temporal expression of two type III intermediate filament proteins in olfactory receptor neurons.
Olfactory receptor neurons (ORNs) do not express the typical neuronal intermediate filament proteins (IFPs), the neurofilament triplet proteins. Immunocytochemical evidence shows that ORNs coexpress vimentin and peripherin but distribute them differently. Specifically, ORNs contain vimentin in dendrites, cell bodies, and axons, but not in terminals in glomeruli; peripherin is present in axons, but excluded from dendrites, cell bodies, and terminal glomeruli. In adult rats, ORN axon fascicles are variably stained with antisera for peripherin; in juvenile rats, staining of fascicles is uniform. Staining with antibody to vimentin is uniform in both adult and juvenile ORN axon fascicles. The unusual pattern of IFP expression and intracellular sorting may have implications for the unique plastic and regenerative capacities of these neurons.
Gorham
J D
JD
Howard Hughes Medical Institute, Department of Biochemistry, New York University Medical Center, New York 10016.
Ziff
E B
EB
Baker
H
H
D000367:Age Factors; D000818:Animals; D015153:Blotting, Western; D002628:Chemoreceptor Cells / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism; D009831:Olfactory Mucosa / Q000196:embryology / Q000378:metabolism; D009833:Olfactory Pathways / Q000378:metabolism*; D064531:Peripherins; D051381:Rats; D014746:Vimentin / Q000378:metabolism
D007381:Intermediate Filament Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D064531:Peripherins; D014746:Vimentin