title: [ADP ribosylation of actin--a cytotoxic principle of bacterial toxins].
abstract: The ADP-ribosylation of actin is the pathobiochemical mechanism by which various clostridial toxins affect the eukaryotic target cell. The toxins are binary in structure and consist of a binding component and an enzyme component with ADP-ribosyltransferase activity. Probably endocytosis-mediated the binding component transfers the clostridial ADP-ribosyltransferase into the target cell, whereupon G-actin but not F-actin is ADP-ribosylated. The ADP-ribosylated actin is incapable of polymerization but binds to the barbed ends of actin filaments to inhibit polymerization of non-modified actin. Thereby the ADP-ribosylation of actin destroys the cellular architecture of the microfilament network. The ADP-ribosylating toxins are novel tools to study the physiological functions of actin.
authors.affiliation: Universitätsklinikum Essen, Institut für Pharmakologie.
authors.forename: I
authors.initials: I
authors.lastname: Just
authors.forename: K
authors.initials: K
authors.lastname: Aktories
mesh_terms: D000199:Actins / Q000378:metabolism*; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D001427:Bacterial Toxins / Q000378:metabolism*; D003013:Clostridium; D006801:Humans; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*
chemical_list: D000199:Actins; D001427:Bacterial Toxins; D000246:Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases
vernacular_title: ADP-Ribosylierung von Aktin--ein zytotoxisches Prinzip bakteriellerToxine.