Lymphokine-activated killer (LAK) cells modulate the effects of IL-2 on a T cell-mediated immune response.
The ability of LAK cells and/or IL-2 to affect the course of an established T cell response was examined in a delayed-type hypersensitivity (DTH) model. IL-2 greatly increased the magnitude of the response at 24 h, while LAK cells alone had no effect. The administration of LAK cells and IL-2 together also had no effect on the magnitude of the DTH response, demonstrating that LAK cells were able to remove the enhancement seen with IL-2 alone. The presence of LAK cells reduced the serum half-life of IL-2 significantly, but not to an extent able to account for the observed loss of IL-2 induced DTH enhancement. IL-2 administration influenced cell phenotypes in the spleen and draining lymph nodes (DLN), as well as increasing splenic weight; the additional presence of LAK cells markedly altered these effects of IL-2 in the spleen (but not the DLN). Taken together, these results suggest that LAK cells interact with activated T-cells within the immune system and modulate their function.
McCulloch
P
P
Department of Surgery, Western Infirmary, Glasgow, Scotland, UK.
Gallagher
G
G
Walsh
L P
LP
Zaloom
Y
Y
Xie
J
J
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002457:Cell Extracts / Q000627:therapeutic use; D003877:Dermatitis, Contact / Q000209:etiology / Q000628:therapy; D004137:Dinitrochlorobenzene; D005260:Female; D006968:Hypersensitivity, Delayed / Q000628:therapy; D007111:Immunity, Cellular / Q000187:drug effects; D007167:Immunotherapy; D007376:Interleukin-2 / Q000494:pharmacology*; D015979:Killer Cells, Lymphokine-Activated / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*
D002457:Cell Extracts; D004137:Dinitrochlorobenzene; D007376:Interleukin-2