title: Gluconeogenesis from propionate produced in the colon of the horse.
abstract: The production of propionate has been measured in the large colon of two ponies fitted with cannulas and fed on a standard diet of hay or hay and wheat bran. A continuous infusion of 14C-labelled sodium propionate was made into a cannula in the right ventral colon and samples of ingesta were obtained from another cannula near the end of the right dorsal colon. A simultaneous intravenous infusion of [2-3H]-labelled glucose was made to measure total glucose entry. Colonic propionate production on the hay diet was 146 (range 110-176) mg/h per kg body weight and, on the hay and bran, 195 (range 130-273) mg/h per kg body weight. Mean total glucose production for the two diets was 120 (range 98-143) and 92 (range 79-116) mg/h per kg body weight, respectively. The results obtained indicate that 50% of the glucose was synthesized from propionate produced in the colon in ponies on the hay diet and 61% in ponies on the hay and bran diet.
authors.affiliation: Department of Veterinary Clinical Science, University of Liverpool, Neston, South Wirral.
authors.forename: H A
authors.initials: HA
authors.lastname: Simmons
authors.forename: E J
authors.initials: EJ
authors.lastname: Ford
mesh_terms: D000818:Animals; D003106:Colon / Q000378:metabolism*; D005943:Gluconeogenesis; D006736:Horses / Q000378:metabolism*; D008297:Male; D011422:Propionates / Q000378:metabolism*
chemical_list: D011422:Propionates