title: Analysis of pH-induced population oscillations of Saccharomyces cerevisiae and Escherichia coli using photon correlation spectroscopy.
abstract: Following a recent successful application of p.c.s. to liquid chromatography in the biotechnology industry, its usefulness as a contamination monitor in the fermentation industry was assessed. It was found that: (i) the intensity bias of the technique limits its uses to the detection of contaminants when they are larger than the host; (ii) the inherent heterogeneity of microbial cultures prevents the use of multiangle studies, and (iii) the large size of bacteria make the use of p.c.s. in flowing, on-line systems impractical.
authors.affiliation: Division of Biotechnology, P.H.L.S. Centre for Applied Microbiology and Research, Porton Down, Wilts, U.K.
authors.forename: R I
authors.initials: RI
authors.lastname: Jepras
authors.forename: J
authors.initials: J
authors.lastname: Rarity
authors.forename: E A
authors.initials: EA
authors.lastname: Perkins
authors.forename: D J
authors.initials: DJ
authors.lastname: Clarke
authors.forename: R J
authors.initials: RJ
authors.lastname: Carr
authors.forename: T
authors.initials: T
authors.lastname: Atkinson
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D004926:Escherichia coli / Q000254:growth & development*; D005285:Fermentation; D007700:Kinetics; D012441:Saccharomyces cerevisiae / Q000254:growth & development*; D013997:Time Factors