Use of recombinant human interferon gamma to enhance neutrophil chemotactic responses in Job syndrome of hyperimmunoglobulinemia E and recurrent infections.
Recombinant human interferon gamma enhances neutrophil respiratory burst and bactericidal activity in patients with chronic granulomatous disease. Mononuclear leukocytes of patients with the hyperimmunoglobulinemia E syndrome (Job syndrome) produce low or undetectable levels of this lymphokine. For these reasons we have restudied neutrophil chemotaxis in a group of our patients with the syndrome and determined the effect of recombinant human interferon gamma on the responses. Each of the patients had neutrophil chemotactic responses ranging from 22% to 55% of simultaneous control values (p less than 0.001). After incubation with interferon gamma, a significant improvement in chemotactic responsiveness was observed in the neutrophils of each of the patients (mean 301% of baseline chemotaxis; p less than 0.008). These data suggest the need for a double-blind, placebo-controlled trial of interferon gamma in a larger group of patients with the syndrome of hyperimmunoglobulinemia E and recurrent infections.
Jeppson
J D
JD
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132.
Jaffe
H S
HS
Hill
H R
HR
D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000097:blood* / Q000503:physiopathology; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D002675:Child, Preschool; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood* / Q000503:physiopathology; D007070:Immunoglobulin A / Q000032:analysis; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007371:Interferon-gamma / Q000494:pharmacology*; D007589:Job Syndrome / Q000097:blood* / Q000503:physiopathology; D009504:Neutrophils / Q000502:physiology*; D011994:Recombinant Proteins; D012008:Recurrence
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011994:Recombinant Proteins; D007073:Immunoglobulin E; D007371:Interferon-gamma