[Ciprofibrate: erythrocyte partition coefficient and binding to serum protein].
The in vitro binding of the lipid lowering agent Ciprofibrat (1) to different plasma protein fractions and its red blood-cell partition coefficient were investigated. The binding-rate to albumin and alpha-globulin is dose-dependent (first order kinetic) and amounts to about 95% for albumin and to 25% for alpha-globulin. The affinity of 1 to beta- and gamma-globulin is non-specific and dose-independent (average binding-rate 8% and 10%, respectively). 1 shows only a weak affinity to erythrocytes, therefore, the red blood-cell partition coefficient is 0.02.
Czejka
M
M
Institut für Pharmazeutische Chemie, Universität Wien, Osterreich.
D001798:Blood Proteins / Q000378:metabolism; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D058607:Fibric Acids; D006801:Humans; D000960:Hypolipidemic Agents / Q000097:blood*; D066298:In Vitro Techniques; D011485:Protein Binding
D001798:Blood Proteins; D058607:Fibric Acids; D000960:Hypolipidemic Agents; D002995:Clofibric Acid; C019304:ciprofibrate
Ciprofibrat: erythrozytenverteilungskoeffizient und Bindung an Serumproteine.