[Enhancement of susceptibility of sulbactam/cefoperazone-treated bacteria to phagocytes].
Effects of sulbactam/cefoperazone (SBT/CPZ) on the host-parasite relationship were studied using an established mouse macrophage cell line. Since SBT inactivates some types of beta-lactamase strongly, a combination of SBT with CPZ shows marked antibacterial activities against the bacteria producing beta-lactamases. In addition, sub-MIC levels of SBT/CPZ made Escherichia coli more susceptible to bactericidal activity of macrophage. This study provides evidence that SBT/CPZ works in partnership with host defense mechanism against bacterial infections in clinical situations.
Tanaka
T
T
1st Department of Internal Medicine, Kagawa Medical School.
Iida-Tanaka
K
K
Irino
S
S
D002438:Cefoperazone / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010587:Phagocytosis / Q000187:drug effects*; D013407:Sulbactam / Q000494:pharmacology*
D002438:Cefoperazone; D013407:Sulbactam