title: [Experimental and clinical studies of urethral anesthesia on etiology and treatment of detrusor-sphincter dyssynergia].
abstract: We studied whether detrusor-sphincter synergia during micturition was obtained by means of urethral anesthesia with lidocaine hydrochloride in five thoracic spinal cats and eight clinical cases with detrusor-sphincter dyssynergia. In thoracic spinal cats with detrusor-sphincter dyssynergia, urethral anesthesia produced detrusor-sphincter synergia, an increase in the maximum bladder pressure and a decrease in the residual volume. In clinical cases with detrusor-sphincter dyssynergia, urethral anesthesia produced detrusor-sphincter synergia or a decrease in the external urethral sphincter activities during micturition, and a decrease in the maximum urethral closure pressure and the residual volume. There were no remarkable changes of the external urethral sphincter activities during urine storage phase before and after urethral anesthesia in both spinal cats and clinical cases. These results suggest that urethral anesthesia blocks the urethro-urethral contraction reflex and secondarily activates vesico-urethral relaxation reflex. The block of urethral sensory nerves is thought to effectively treat detrusor-sphincter dyssynergia.
authors.affiliation: Department of Urology, Akita University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Sugaya
authors.forename: O
authors.initials: O
authors.lastname: Nishizawa
authors.forename: H
authors.initials: H
authors.lastname: Noto
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Tsukada
authors.forename: T
authors.initials: T
authors.lastname: Kohama
authors.forename: N
authors.initials: N
authors.lastname: Shimoda
authors.forename: S
authors.initials: S
authors.lastname: Tsuchida
mesh_terms: D000772:Anesthesia, Local; D000818:Animals; D002415:Cats; D008012:Lidocaine; D009119:Muscle Contraction; D012018:Reflex / Q000502:physiology; D013119:Spinal Cord Injuries / Q000503:physiopathology; D014521:Urethra / Q000503:physiopathology*; D001743:Urinary Bladder / Q000503:physiopathology*; D001750:Urinary Bladder, Neurogenic / Q000503:physiopathology*; D014554:Urination
chemical_list: D008012:Lidocaine