Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides.
We describe functional simplified T cell and Fc receptor chimeras that are capable of directing CD8+ cytotoxic T lymphocytes (CTLs) to specifically recognize and lyse cells expressing HIV envelope proteins. Target cells bearing HLA-DR molecules are not recognized by CTL armed with the chimeras. The variety of cell types in which the native receptors are active suggests multiple possibilities for antiviral intervention through genetic means.
Romeo
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C
Department of Genetics, Harvard Medical School, Boston, Massachusetts.
Seed
B
B
D000595:Amino Acid Sequence; D015703:Antigens, CD / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D015704:CD4 Antigens / Q000235:genetics / Q000276:immunology*; D016827:CD8 Antigens; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D002678:Chimera; D003602:Cytotoxicity, Immunologic; D006678:HIV / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology*; D011961:Receptors, Fc / Q000235:genetics / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology*
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D011948:Receptors, Antigen, T-Cell; D011961:Receptors, Fc; D014759:Viral Envelope Proteins; D002118:Calcium