A practical guide to nitrate use.
Nitrate preparations are useful in the treatment of acute and chronic angina, acute and chronic congestive heart failure, and acute myocardial infarction. Development of tolerance is best managed by providing a nitrate-free interval, thus avoiding continuous drug levels. This interval probably should be 10 to 12 hours with use of a transdermal patch. Nitrate treatment of the elderly may require lower doses to avoid hypotension.
Anderson
K A
KA
Parkview Internal Medicine Associates, St. Paul.
D000787:Angina Pectoris / Q000188:drug therapy; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy; D005996:Nitroglycerin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011654:Pulmonary Edema / Q000188:drug therapy
D005996:Nitroglycerin; D007548:Isosorbide Dinitrate