Acrolein genotoxicity in Drosophila melanogaster. I. Somatic and germinal mutagenesis under proficient repair conditions.
The genotoxicity of acrolein in D. melanogaster was investigated using 2 different SMART assays, the eye spot and wing spot tests, and 2 germinal tests, the sex-linked recessive lethal (SLRLT) and sex chromosome loss (SCLT) tests. For the 2 latter, exposure by feeding as well as injection was used. The results indicate that: (i) acrolein is mutagenic in the SLRLT when injected but not when fed; (ii) the SCLT did not reveal clastogenic effects; (iii) acrolein had genotoxic effects in both SMART assays; (iv) we also had several indications that acrolein is metabolized into a second genotoxic product.
Sierra
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LM
Departamento de Biología Funcional, Universidad de Oviedo, Spain.
Barros
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AR
García
M
M
Ferreiro
J A
JA
Comendador
M A
MA
D000171:Acrolein / Q000633:toxicity*; D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D005804:Genes, Lethal; D005808:Genes, Recessive; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens; D012730:Sex Chromosomes
D009153:Mutagens; D000171:Acrolein