[The lymphocyte acetylcholinesterase activity in rats poisoned by pesticides].
The experiments carried out present the evidence of acetylcholinesterase activity of Wistar rat lymphocytes. It was shown that splenocytes and thymocytes had significantly different levels of the enzyme activity. Peroral administration of phosphor-organic pesticide antio (phormothion) 1/100 and 1/20 LD50 induced the dose-dependent inhibition of splenocyte acetylcholine-esterase activity after 2 months of treatment. It suggests the relation of the immunosuppressive action of pesticide with the interference into the neuromediator mechanisms regulating the lymphoid cell function.
Gushchin
B V
BV
Khaĭdarova
D S
DS
Kugusheva
L I
LI
Rozengart
V I
VI
Korneva
E A
EA
D000110:Acetylcholinesterase / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D008214:Lymphocytes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009946:Organothiophosphorus Compounds / Q000506:poisoning; D010575:Pesticides / Q000506:poisoning*; D011041:Poisoning / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects / Q000201:enzymology; D013950:Thymus Gland / Q000187:drug effects / Q000201:enzymology
D009946:Organothiophosphorus Compounds; D010575:Pesticides; D000110:Acetylcholinesterase
Aktivnost' atsetilkholinésterazy limfotsitov krys pri intoksikatsii pestitsidami.