title: [Analysis of kinetics of consecutive metabolic cerebral activations induced by spatial discrimination testing, using (14C)-glucose, in an eight-arm radial maze in mice].
abstract: Regional mapping of relative (14C)-glucose (GLU) uptake was analyzed in Balb/c mice at 3 time intervals (5 min., 1 hr., 3 hrs.) after either the first (Day 1) or the last (Day 9) daily sessions of a spatial discrimination testing procedure in an eight-arm radial maze. On Day 1, increased labelling was found 5 min. post-training in subcortical, hippocampal and cortical regions. Decreased GLU uptake was observed 1 hr. later in the same regions, followed at 3 hrs. post-training by a retarded activation in the above areas and particularly in thalamic and cortical structures. On Day 9, there was only an early (5 min.) post-training increase in metabolic activity followed by a subsequent monotonic decrease over 3 hrs. post-training period.
authors.forename: B
authors.initials: B
authors.lastname: Bontempi
authors.forename: J
authors.initials: J
authors.lastname: Sif
authors.forename: R
authors.initials: R
authors.lastname: Jaffard
authors.forename: C
authors.initials: C
authors.lastname: Destrade
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D004192:Discrimination, Psychological; D005947:Glucose / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013028:Space Perception
chemical_list: D002250:Carbon Radioisotopes; D005947:Glucose
vernacular_title: Analyse par le (14C)-glucose de la cinétique des activations métaboliques cérébrales consécutives à l'apprentissage d'une discrimination spatiale dans un labyrinthe radial à huit bras chez la souris.