title: [No rearrangement of the breakpoint cluster region in two juvenile chronic myeloid leukemia].
abstract: We performed cytogenetic studies and breakpoint cluster region (bcr) rearrangement analysis in two cases of juvenile chronic myeloid leukemia (JCML) which is special type of chronic myeloid leukemia (CML). Case 1 (8-month-old male) and case 2 (3-month-old female) showed clinical and hematologic manifestations similar to CML. Each of case 1 and 2 had normal karyotype and no bcr rearrangement. These findings suggest that JCML is a different heterogeneous disorder from that of adult CML.
authors.affiliation: Department of Internal Medicine, Atomic Disease Institute, Nagasaki University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Tokunaga
authors.forename: N
authors.initials: N
authors.lastname: Sadamori
authors.forename: M
authors.initials: M
authors.lastname: Tomonaga
authors.forename: M
authors.initials: M
authors.lastname: Ichimaru
authors.forename: K
authors.initials: K
authors.lastname: Kinoshita
authors.forename: M
authors.initials: M
authors.lastname: Yanai
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuji
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
mesh_terms: D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007223:Infant; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D005810:Multigene Family