A clinical trial of a topical preparation of miconazole, polymyxin and prednisolone in the treatment of otitis externa in dogs.
A topical preparation containing miconazole, polymyxin and prednisolone was shown to be more effective in the treatment of otitis externa in 167 dogs than 2 other ear preparations containing antibiotics, an antimycotic and a corticosteroid. With miconazole, polymyxin and prednisolone, the recurrence rate was 26.7% compared with 72.6% and 54.3% when the other products were used. The mean duration of treatment required to achieve resolution of clinical signs was 9.6 days, compared with 12.2 days and 13.0 days and no cases failed to respond to treatment, compared with 17.7% and 14.3%. Malassezia canis alone (71%) or in association with bacteria (18%) was recovered from 44 of 49 ears cultured.
Studdert
V P
VP
Department of Veterinary Science, University of Melbourne, Parkville, Victoria.
Hughes
K L
KL
D000287:Administration, Topical; D000818:Animals; D001623:Betamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D004221:Disulfiram / Q000008:administration & dosage / Q000627:therapeutic use / Q000031:analogs & derivatives; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004338:Drug Combinations; D008825:Miconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D009355:Neomycin / Q000008:administration & dosage / Q000627:therapeutic use; D009761:Nystatin / Q000008:administration & dosage / Q000627:therapeutic use; D010032:Otitis Externa / Q000188:drug therapy / Q000662:veterinary*; D011112:Polymyxin B / Q000008:administration & dosage / Q000627:therapeutic use*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D012008:Recurrence; D013883:Thiostrepton / Q000008:administration & dosage / Q000627:therapeutic use; D014221:Triamcinolone / Q000008:administration & dosage / Q000627:therapeutic use
D004338:Drug Combinations; D009761:Nystatin; C009822:monosulfiram; D014221:Triamcinolone; D008825:Miconazole; D001623:Betamethasone; D011239:Prednisolone; D013883:Thiostrepton; D009355:Neomycin; D011112:Polymyxin B; D004221:Disulfiram