title: Nephrogenic diabetes insipidus. An unusual presentation of recurrent rectal cancer.
abstract: The occurrence of diabetes insipidus (DI) in patients with systemic cancer is caused usually by tumor metastasis to the hypothalamus or posterior pituitary. A 43-year-old man with DI 8 months after radical surgery for a poorly differentiated adenocarcinoma of the distal rectum is reported. A therapeutic trial of intranasal desmopressin acetate did not correct the hyposthenuria, thus localizing the defect to the kidneys. A large tumor recurrence in the pelvis caused bilateral hydroureteronephrosis, resulting in nephrogenic DI. This report shows that not all cases of DI in cancer patients are of central origin.
authors.affiliation: Department of Endocrinology, University Hospital Antwerpen, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Nobels
authors.forename: L
authors.initials: L
authors.lastname: Colemont
authors.forename: M
authors.initials: M
authors.lastname: Goethals
authors.forename: R
authors.initials: R
authors.lastname: Abs
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood; D003919:Diabetes Insipidus / Q000097:blood / Q000209:etiology*; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology; D008297:Male; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D010257:Paraneoplastic Syndromes; D012004:Rectal Neoplasms / Q000150:complications* / Q000473:pathology; D014517:Ureteral Obstruction / Q000209:etiology; D001749:Urinary Bladder Neoplasms / Q000473:pathology
chemical_list: D001127:Arginine Vasopressin