[Experimental study on local attachment of Beriplast P membrane including MMC].
We studied the effect of Beriplast P membrane including MMC (2 mg/ml) on human gastric carcinoma implanted in nude mouse (OSS) as a example of a shallow but broad lesion as with an early-stage local recurrence of rectal cancer and superficial gastric cancer. As a result, the resected tumor contact Beriplast P membrane including MMC after 3 days showed continuous necrotic lesions, from 1 to 2 mm in depth. No side effect was observed in nude mice. These results indicated that Beriplast P membrane including MMC is a useful chemotherapy against local cancerous lesion.
Takahashi
Y
Y
Dept. of Surgery, Cancer Research Institute, Kanazawa University.
Minami
S
S
Ohta
T
T
Suga
T
T
Fujioka
N
N
Mai
M
M
D000818:Animals; D000970:Antineoplastic Agents; D015718:Fibrin Tissue Adhesive; D006801:Humans; D008566:Membranes; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D016685:Mitomycin; D008937:Mitomycins; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000473:pathology*
D000970:Antineoplastic Agents; D015718:Fibrin Tissue Adhesive; D008937:Mitomycins; D016685:Mitomycin