Strychnine antagonizes jaw-closer motoneuron IPSPs induced by reticular stimulation during active sleep.
In chronic, unanesthetized, normally respiring cats, stimulation of the nucleus reticularis pontis oralis induced inhibitory postsynaptic potentials (IPSPs) in masseter motoneurons during active sleep, but not during wakefulness or quiet sleep. Strychnine, when applied juxtacellularly by microiontophoresis to masseter motoneurons, specifically suppressed the active sleep-dependent IPSPs. In contrast, bicuculline did not suppress the active sleep-dependent IPSPs. These results indicate these IPSPs are mediated by the putative neurotransmitter glycine.
Chirwa
S S
SS
Department of Physiology, University of California, Los Angeles 90024.
Stafford-Segert
I
I
Soja
P J
PJ
Chase
M H
MH
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D002415:Cats; D008406:Masseter Muscle / Q000294:innervation; D009046:Motor Neurons / Q000187:drug effects*; D009433:Neural Inhibition / Q000187:drug effects; D012154:Reticular Formation / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D013331:Strychnine / Q000494:pharmacology*
D013331:Strychnine; D001640:Bicuculline