[Calcium dependence of the contractile response of the aorta in the rat, rabbit and guinea pig and in the human uterine artery].
The influence of extracellular Ca2+ on the contraction produced by noradrenaline (NA) (3 x 10(-6) M), KCl (60 mM) and BaCl2 (30 mM) on human uterine arteries (AUH) and aortic strips from rats, rabbits and guinea-pigs have been studied. The vessels were cut spirally and incubated in Krebs solution containing 2.5 mM Ca2+ (KN), 0 mM Ca2+ (K-0Ca) or 0 mM Ca2+ + 3 mM EDTA (K-EDTA). Both phases (fast and slow) of the response of aortic strips to NA and of the AUH to NA, KCl and BaCl2 were significantly smaller in solutions without Ca2+. Only in rabbit aortic strips the slow phase was significantly more reduced than the fast phase. Overall, the contractions of the rat aortic strips were most resistant to the absence of extracellular Ca2+. These results confirm the variability of the responses of blood vessels from different vascular beds and species to the removal of extracellular Ca2+.
García de Boto
M J
MJ
Departamento de Medicina, Facultad de Medicina, Oviedo, España.
Molina
R
R
Andrés-Trelles
F
F
Hidalgo
A
A
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001464:Barium / Q000494:pharmacology; D017609:Barium Compounds; D002118:Calcium / Q000502:physiology*; D002712:Chlorides; D004492:Edetic Acid / Q000494:pharmacology; D005110:Extracellular Space; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014599:Uterus / Q000098:blood supply
D017609:Barium Compounds; D002712:Chlorides; C024986:barium chloride; D001464:Barium; D011189:Potassium Chloride; D004492:Edetic Acid; D002118:Calcium; D009638:Norepinephrine
Dependencia del calcio de la respuesta contráctil de aorta de rata, conejo y cobaya y arteria uterina humana.