[Quantitative study of rat diabetic cataract, by the relaxation times of nuclear magnetic resonance].
The prophylactic effects of a new aldose reductase inhibitor (ARI), FR74366 on streptozotocin-induced rat diabetic cataract were examined by means of proton nuclear magnetic resonance (1H-NMR) relaxation time. We compared the findings with the histological finding, and it was recognized that longitudinal and transverse relaxation times (T1, T2) were prolonged before the histological changes appeared. The ARI, FR74366, prevented histologic changes and had detected by the 1H-NMR method. The results showed that 1H-NMR could be useful in the early detection of human diabetic cataract and the evaluation of the effectiveness of anti-cataract agents, for example, AR inhibitors.
Mori
K
K
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.
Terubayashi
H
H
Akagi
Y
Y
Okamoto
S
S
Tsutsumi
M
M
Ikebe
H
H
Yoshizaki
K
K
Nishikawa
H
H
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D000818:Animals; D002386:Cataract / Q000473:pathology* / Q000517:prevention & control; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011799:Quinazolines / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors
D011799:Quinazolines; C064920:FR 74366; D000449:Aldehyde Reductase