Increased dietary sodium chloride in patients treated with antihypertensive drugs.
Eleven patients on a normal diet with mild to moderate essential hypertension satisfactorily treated with diverse hypotensive agents entered a randomized double-blind cross-over study to evaluate the effect of additional sodium chloride (100 mmol slow sodium) compared with placebo on blood pressure control over a 6 week period. Despite excellent tablet compliance, sodium chloride failed to significantly alter mean supine or erect blood pressure. These findings as well as a review of the relevant literature suggest that excess dietary sodium does not jeopardize blood pressure control in such patients.
Carney
S L
SL
Hunter Hypertension Research Group, Faculty of Medicine, University of Newcastle, N.S.W., Australia.
Gillies
A H
AH
Smith
A J
AJ
Smitham
S
S
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012982:Sodium, Dietary / Q000008:administration & dosage*
D000959:Antihypertensive Agents; D012982:Sodium, Dietary