title: Costs of bone marrow transplants using unrelated donors.
abstract: Bone marrow transplantation is an expensive treatment, rationed primarily by the availability of donors. Recruiting potential unrelated bone marrow donors to a register would add not only to the cost, but also to the volume, of transplantation. Proposals to establish such registries have thus been subject to rigorous financial scrutiny. In Australia, 3 alternative estimates suggest that approximately 200 patients, otherwise suitable for bone marrow transplantation, do not receive transplants because they have no suitable related donor. The population of Australia is approximately 16 million. The alternatives for these patients are thus chemotherapy or unrelated bone marrow transplantation. The costs of chemotherapy and transplantation have been directly compared in 1 trial of treatment for acute nonlymphoblastic leukaemia. The cost per year of life saved was approximately the same for the 2 treatments, with better patient survival from transplantation. The estimated cost difference in both the United States and Australia, between the policy extremes of no patients transplanted, and all transplanted, was between 1.3-2.4% of the total costs of managing these patients. The cost of searching existing registers for unrelated donors for Australian patients, averages A$24,000-28,000 to the point of a successful donor procedure. The cost of establishing and maintaining an Australian Register of a size predicted to find donors for half of the potential recipients, has been estimated at A$ 10,000 per donor procedure. The decision to proceed with unrelated bone marrow transplantation commits resources that are currently used by the alternative therapies. It is thus important to monitor both the costs and effects of the new approach.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Tissue Typing Laboratory, Red Cross Blood Transfusion Service, Sydney, NSW, Australia.
authors.forename: J R
authors.initials: JR
authors.lastname: Chapman
authors.forename: K
authors.initials: K
authors.lastname: Atkinson
authors.forename: H
authors.initials: H
authors.lastname: Lapsley
mesh_terms: D000970:Antineoplastic Agents / Q000191:economics; D016026:Bone Marrow Transplantation / Q000191:economics* / Q000706:statistics & numerical data; D003657:Decision Making; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000191:economics / Q000601:surgery; D009517:New South Wales; D012042:Registries; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000191:economics* / Q000379:methods; D014861:Washington
chemical_list: D000970:Antineoplastic Agents