A non-invasive monitoring of exposure to an industrial organic solvent, dimethylformamide.
A urinary metabolite, N-hydroxymethyl-N-methyl formamide (DMF-OH) was measured by a colorimetric method in Wistar and Sprague-Dawley rat urine after a single exposure to N,N-dimethyl formamide (DMF). A linear relationship was found between the total excretion of DMF-OH in 2 days versus the exposure ranging from 1 to 20% of the LD50 of DMF i.e. 47.2 to 944 mg DMF per kg b. wt. This is proposed to be a non-invasive biological method for monitoring exposure to DMF.
Chang
M J
MJ
Department of Public Health, Chang Gung Medical College, Taiwan.
Lin
R S
RS
D000818:Animals; D004126:Dimethylformamide / Q000378:metabolism*; D004784:Environmental Monitoring; D005260:Female; D016273:Occupational Exposure; D051381:Rats; D011919:Rats, Inbred Strains
D004126:Dimethylformamide