[Efficacy evaluation of cloxacillin and cloxacillin-gentamicin in an experimental model of methicillin-sensitive Staphylococcus aureus].
23 rabbits with Staphylococcus aureus methicillin-sensitive, SAMS, experimentally induced endocarditis (EIE) were studied to compare the efficacy of cloxacillin vs the association cloxacillin-gentamicin. Twelve animals made the control group and 11 the treated ones, 5 with cloxacillin-gentamicin and 6 with cloxacillin. The animals were treated 3 days, then, mortality, blood cultures at 48 and 72 hours and the title of the unit-forming colonies per gram of vegetation (UFC/g) were evaluated. The control group had a mortality of 100% in the first 72 hours, its blood cultures were positive at 48 and 72 hours and the UFC/g was 10,48 o 0.20. There was statistical significance between the control group and both treatment, in mortality, blood culture's positivity and the UFC/g of vegetation. This results confirm the similar efficacy of cloxacillin either alone or in combination in the treatment of SAMSIE and the effectiveness of the experimental model to evaluate antimicrobial treatments.
Apellaniz Sainz-Trapaga
G
G
Facultad de Medicina de Murcia.
Valdes Chavarri
M
M
Pérez Costa
R
R
Martín Luengo
F
F
García Alberola
A
A
Soria Arcos
F
F
Gómez Gómez
J
J
D000818:Animals; D003023:Cloxacillin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D005839:Gentamicins / Q000627:therapeutic use*; D008712:Methicillin / Q000494:pharmacology; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy*
D005839:Gentamicins; D003023:Cloxacillin; D008712:Methicillin
Valoración de la eficacia de la cloxacilina y cloxacilina-gentamicina en un modelo experimental de Staphylococcus aureus meticilín-sensible.