title: Effect of lifelong hypocaloric diet on discrete memory of the senescent rat.
abstract: The memory retention abilities of aged rats fed different diets were assessed in two different avoidance tasks. The standard passive avoidance procedure revealed an age-related memory impairment in old rats fed a standard diet (ST), whereas old rats fed a hypocaloric diet (HY) behaved similarly to young animals. To clarify whether this deficit could be attributed only to cognitive decay and not other factors, such as the tendency of old rats to prefer darkness to light more than young and adult animals, a multiple passive avoidance task was performed. This test offers rats the possibility to escape to a dark chamber in which they have never been shocked, and thus provides a means of checking factors other than memory retention abilities. All the old rats showed a more marked preference to escape to darkness compared to young and adult animals. However, senescent animals fed a ST diet had poor memory retention abilities compared to aged animals fed the HY diet, and young and adult rats. The results of this test confirmed the findings of the standard passive avoidance task.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Pitsikas
authors.forename: P
authors.initials: P
authors.lastname: Garofalo
authors.forename: A
authors.initials: A
authors.lastname: Manfridi
authors.forename: A
authors.initials: A
authors.lastname: Zanotti
authors.forename: S
authors.initials: S
authors.lastname: Algeri
mesh_terms: D000375:Aging / Q000523:psychology*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D004032:Diet; D002149:Energy Intake; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D051381:Rats