[The role of prostaglandins in the development of cardio- and hemodynamic disorders in postischemic shock].
Experiments on anaesthetized dogs have shown, that reperfusion of ischemized tissues is accompanied by significant increase in thromboxane A2 (Tx A2) and prostacyclin (PG I2) blood level and by development of pronounced cardiovascular insufficiency. Preliminary blockade of prostaglandins biosynthesis prevent an increase of TbA2 and PG12 blood level, postreperfusion disturbances of central and regional circulation develop later and are less pronounced. Therefore, endogenic prostaglandins take part in the development of post ischemic shock reaction, influencing chiefly the venous vessels and blood return to heart.
Sagach
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Zhukova
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D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D004285:Dogs; D011464:Epoprostenol / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011453:Prostaglandins / Q000502:physiology*; D015424:Reperfusion; D012769:Shock / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D013928:Thromboxane A2 / Q000097:blood; D013997:Time Factors
D011453:Prostaglandins; D002245:Carbon Dioxide; D013928:Thromboxane A2; D011464:Epoprostenol; D010100:Oxygen; D007213:Indomethacin
Rol' prostaglandinov v razvitii narusheniĭ kardio- i gemodinamiki pri postishemicheskom shoke.