Temperature regulation of the cryptococcal phenoloxidase.
Melanin formation at 37 degrees C has been proposed as a virulence factor in Cryptococcus neoformans. However, whereas catecholamine uptake is maintained at this temperature, phenoloxidase, which catalyses the oxidation of catecholamine to melanin, is severely decreased in most wild type strains cultivated at 37 degrees C.
Jacobson
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Research Service, McGuire Veterans Affairs Medical Centre, Richmond, Virginia 23249.
Emery
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HS
D002395:Catecholamines / Q000378:metabolism; D003455:Cryptococcus neoformans / Q000201:enzymology* / Q000472:pathogenicity; D008543:Melanins / Q000096:biosynthesis; D014442:Monophenol Monooxygenase / Q000378:metabolism*; D010084:Oxidation-Reduction; D013696:Temperature; D014510:Urease / Q000378:metabolism; D014774:Virulence
D002395:Catecholamines; D008543:Melanins; D014442:Monophenol Monooxygenase; D014510:Urease