Pharmacological consequences of cholinergic plus serotonergic manipulations.
The present study investigated pharmacological consequences of combined cholinergic and serotonergic blockade. Raphe medianus (RM) lesions (5,7-DHT) had no effect on spatial learning, but augmented scopolamine 0.8 mg/kg induced learning deficit. Pilocarpine (4 mg/kg) could reverse scopolamine (0.8 mg/kg), but not scopolamine (0.8 mg/kg) + RM lesion induced spatial learning impairment. However, a higher dose of pilocarpine could restore spatial learning deficit induced by scopolamine (0.8 mg/kg) and RM lesions. These findings support the important role of cholinergic-serotonergic interaction in the regulation of spatial learning and suggests that the combined cholinergic-serotonergic deficit in patient's with Alzheimer's disease may have an impact on therapeutic approaches which seek to normalize AD related cognitive impairments.
Riekkinen
P
P
Department of Neurology, University of Kuopio, Finland.
Sirviö
J
J
Valjakka
A
A
Miettinen
R
R
Riekkinen
P
P
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D007858:Learning / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010862:Pilocarpine / Q000494:pharmacology; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012601:Scopolamine / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*; D013028:Space Perception
D010862:Pilocarpine; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D012601:Scopolamine; D004298:Dopamine; D009638:Norepinephrine