[Aluminum absorption in the presence of normal kidney function: the effect of the pH].
Aluminium is a toxic metal of known importance in patients with chronic renal failure on hemodialysis, with a gastrointestinal absorption modulated by several factors including gastric pH which modifies the solubility of Aluminium hydroxide and can increase its absorption. We studied twenty six patients with normal renal function: control (n = 13); presurgery (n = 8); postsurgery (n = 5) by an aluminium hydroxide absorption test (30 mg/kg); serum and urinary aluminium was determined as well as gastric pH and hematologic parameters at different time periods. It was observed that presurgery ulcer patients (pH mean = 2.09) increased serum and urine aluminium levels as well as aluminium/creatinine ratio in urine after the test, opposite to what occurs in the postsurgery group (pH mean = 5.78) in which such parameters were not significantly modified. No differences were found in hematological parameters between the two groups. Our results indicate that acid gastric pH seems to be a factor capable of increasing gastrointestinal absorption of aluminium hydroxide since its solubility and thus its disponibility is increased, and make a point on the risk of a prolonged administration of antacids containing aluminium in patients with normal renal function.
Olaizola Ottonello
I
I
Unidad de Investigación Metabolismo Oseo y Mineral, Hospital General de Asturias, Oviedo, España.
Serrano Arias
M
M
Vizoso Piñeiro
F
F
Rodrigo Saez
L
L
García Morán
M
M
Cannata Andía
J B
JB
D000042:Absorption; D000328:Adult; D000535:Aluminum / Q000097:blood; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy / Q000378:metabolism; D013997:Time Factors
D000536:Aluminum Hydroxide; D000535:Aluminum
Absorción de aluminio en presencia de función renal normal: efecto del pH.