Sleep disturbance and Alzheimer's disease: relationship to behavioral problems.
We studied the sleep characteristics of 108 outpatients with probable Alzheimer's disease and found that sleep disturbance was significantly related to daytime behavioral disturbance but not to cognitive impairment. Possible treatment strategies and neuropathological and neurochemical mechanisms are discussed.
Rebok
G W
GW
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Rovner
B W
BW
Folstein
M F
MF
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000523:psychology; D001519:Behavior; D003071:Cognition; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012893:Sleep Wake Disorders / Q000150:complications* / Q000523:psychology / Q000628:therapy