title: Modulation of a Shaker potassium A-channel by protein kinase C activation.
abstract: Brain fast transient K+ channel (A channel) is known to be modulated by PKC activation. We studied, by two-electrode voltage clamp, the molecular mechanism of modulation by PKC activation of A-channels expressed in Xenopus oocytes from the Shaker H4 clone. The modulation is inhibitory affecting primarily the maximal conductance of the channels. A secondary effect is a small change in the voltage-dependence of activation and inactivation of the channel.
authors.affiliation: Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Moran
authors.forename: N
authors.initials: N
authors.lastname: Dascal
authors.forename: I
authors.initials: I
authors.lastname: Lotan
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics; D004553:Electric Conductivity; D004789:Enzyme Activation / Q000187:drug effects; D008564:Membrane Potentials; D015221:Potassium Channels / Q000502:physiology*; D011493:Protein Kinase C / Q000502:physiology*; D011994:Recombinant Proteins; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D015221:Potassium Channels; D011994:Recombinant Proteins; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate