title: [Efficacy evaluation of cloxacillin and cloxacillin-gentamicin in an experimental model of methicillin-sensitive Staphylococcus aureus].
abstract: 23 rabbits with Staphylococcus aureus methicillin-sensitive, SAMS, experimentally induced endocarditis (EIE) were studied to compare the efficacy of cloxacillin vs the association cloxacillin-gentamicin. Twelve animals made the control group and 11 the treated ones, 5 with cloxacillin-gentamicin and 6 with cloxacillin. The animals were treated 3 days, then, mortality, blood cultures at 48 and 72 hours and the title of the unit-forming colonies per gram of vegetation (UFC/g) were evaluated. The control group had a mortality of 100% in the first 72 hours, its blood cultures were positive at 48 and 72 hours and the UFC/g was 10,48 o 0.20. There was statistical significance between the control group and both treatment, in mortality, blood culture's positivity and the UFC/g of vegetation. This results confirm the similar efficacy of cloxacillin either alone or in combination in the treatment of SAMSIE and the effectiveness of the experimental model to evaluate antimicrobial treatments.
authors.affiliation: Facultad de Medicina de Murcia.
authors.forename: G
authors.initials: G
authors.lastname: Apellaniz Sainz-Trapaga
authors.forename: M
authors.initials: M
authors.lastname: Valdes Chavarri
authors.forename: R
authors.initials: R
authors.lastname: Pérez Costa
authors.forename: F
authors.initials: F
authors.lastname: Martín Luengo
authors.forename: A
authors.initials: A
authors.lastname: García Alberola
authors.forename: F
authors.initials: F
authors.lastname: Soria Arcos
authors.forename: J
authors.initials: J
authors.lastname: Gómez Gómez
mesh_terms: D000818:Animals; D003023:Cloxacillin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D005839:Gentamicins / Q000627:therapeutic use*; D008712:Methicillin / Q000494:pharmacology; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy*
chemical_list: D005839:Gentamicins; D003023:Cloxacillin; D008712:Methicillin
vernacular_title: Valoración de la eficacia de la cloxacilina y cloxacilina-gentamicina en un modelo experimental de Staphylococcus aureus meticilín-sensible.