[Effects of ethomersol on cerebrovascular blood circulation and oxygen metabolism of the brain in acute transient ischemia and recirculation].
Intravenous infusion of ethomersol (50 mg/kg during 60 min) decreased cerebral tissue hypoxia at the end of acute cerebral ischemia in cats (30-min occlusion of both carotid and both vertebral arteries). In recirculatory period ethomersol prevented the postischemic hypoperfusion and especially hypo-oxygenation. Ethomersol-induced reduction of Hb-affinity to O2 was demonstrated.
Plotnikova
T M
TM
Kulakova
Z V
ZV
Plotnikov
M B
MB
D000208:Acute Disease; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D002534:Hypoxia, Brain / Q000188:drug therapy; D007262:Infusions, Intravenous; D002546:Ischemic Attack, Transient / Q000188:drug therapy*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D001562:Benzimidazoles; C070941:ethomersol
Vliianie étomerzola na krovosnabzhenie i kislorodnyĭ obmen mozga pri ostroĭ tranzitornoĭ ishemii i retsirkuliatsii.