title: Respiratory effects of spinal anesthesia: resting ventilation and single-breath CO2 response.
abstract: The effects of spinal anesthesia with bupivacaine or lidocaine on resting pulmonary ventilation and on the response to the single-breath carbon dioxide test were studied in 11 unpremedicated patients. Resting end-tidal PCO2 decreased from 34.8 +/- 4.5 (mean +/- SD) to 31.6 +/- 4.6 mm Hg after induction of spinal anesthesia (P = 0.002). The decrease in end-tidal PCO2 correlated negatively with patient age (r = -0.67, P = 0.02) and positively with spinal analgesic level (r = 0.58, P = 0.06). Breath-to-breath variability of ventilation increased during spinal anesthesia. Spinal anesthesia was not associated with statistically significant changes in tidal volume, respiratory rate, minute ventilation, mean inspiratory flow rate, inspiratory duty cycle duration, or the response to the single-breath CO2 test.
authors.affiliation: Department of Anesthesia, Brigham and Women's Hospital, Boston, MA 02115.
authors.forename: R A
authors.initials: RA
authors.lastname: Steinbrook
authors.forename: M
authors.initials: M
authors.lastname: Concepcion
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000775:Anesthesia, Spinal; D001944:Breath Tests; D002045:Bupivacaine / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000097:blood / Q000502:physiology; D002628:Chemoreceptor Cells / Q000502:physiology; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D012119:Respiration / Q000187:drug effects*; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide; D008012:Lidocaine; D002045:Bupivacaine