title: Electron microscopic changes on the DMBA induced oral precancerous and cancerous lesion in hamster cheek pouch.
abstract: Experiments were performed to study the early and late ultrastructural changes during hamster cheek pouch carcinogenesis using a regimen of topical application of 9,10 dimethyl-1-1-2 benzanthracene (DMBA) twice a week in liquid paraffin oil. The DMBA was administered for a period of 2 and 4 1/2 months. Hamsters exposed to DMBA for 2 months developed moderate precancerous changes, whereas the hamsters treated with DMBA for 4 1/2 months developed frank and multiple oral tumors with a cauliflower appearance. The ultrastructural pathological changes seen were considerably increased at 4 1/2 months compared with a 2 month period of DMBA treatment. Untreated and solvent control hamsters cheek pouch treated for 2 and 4 1/2 months with liquid paraffin oil alone did not show any premalignant or malignant changes during this period.
authors.affiliation: Cell Biology Division, Cancer Research Institute, Tata Memorial Centre, Bombay, India.
authors.forename: S V
authors.initials: SV
authors.lastname: Kandarkar
authors.forename: P S
authors.initials: PS
authors.lastname: Gijare
authors.forename: K V
authors.initials: KV
authors.lastname: Rao
authors.forename: S V
authors.initials: SV
authors.lastname: Bhide
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000648:ultrastructure*; D002610:Cheek; D006224:Cricetinae; D007972:Leukoplakia, Oral / Q000139:chemically induced / Q000648:ultrastructure*; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D009061:Mouth Mucosa / Q000648:ultrastructure*; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000648:ultrastructure*
chemical_list: D015127:9,10-Dimethyl-1,2-benzanthracene