Comparison of radionuclide estimation of glomerular filtration rate using technetium 99m diethylenetriaminepentaacetic acid and chromium 51 ethylenediaminetetraacetic acid.
Simultaneous measurements of the clearance rates of technetium 99m diethylenetriaminepentaacetic acid (99mTc-DTPA) and chronium 51 ethylenediaminetetraacetic acid (51Cr-EDTA) were performed in 30 patients with a range of renal function (glomerular filtration rates between 9 and 120 ml/min). Using multiple blood samples, the two clearance values correlated well (r = 0.991, standard error 3.9 ml/min), but DTPA clearance was systematically higher by 7.6%. For each radiopharmaceutical, an equation was derived to correct clearance values obtained using only plasma samples taken at 2 and 4 h for the systematic error inherent in this technique compared with analysis of the complete plasma concentration-time curve. The root mean square error remaining after application of these equations was 1.9 ml/min for both the EDTA and DTPA data. The corresponding errors obtained using the equation derived by Brochner-Mortensen for EDTA plasma clearance were 2.2 ml/min and 1.9 ml/min, respectively, these values were not significantly different from those obtained using the equations derived in this study.
Fleming
J S
JS
Department of Nuclear Medicine, Southampton General Hospital, Shirley, UK.
Wilkinson
J
J
Oliver
R M
RM
Ackery
D M
DM
Blake
G M
GM
Waller
D G
DG
D000328:Adult; D000368:Aged; D002860:Chromium Radioisotopes; D004492:Edetic Acid; D005919:Glomerular Filtration Rate; D006801:Humans; D008875:Middle Aged; D016284:Technetium Tc 99m Pentetate
D002860:Chromium Radioisotopes; D004492:Edetic Acid; D016284:Technetium Tc 99m Pentetate