[Potentiation of the antiketogenic effect of exogenous glucose with the help of the new beta-oxidation inhibitor mildronate--3-(2,2,2-trimethylhydrazine)propionate].
Antiketogenic effect of exogenous glucose (2 g/kg, per os, 1 hr before death) was potentiated after preadministration of mildronate 3-(2,2,2-trimethylhydrazinium) propionate into rats either kept on usual ration or fasting within 48 hrs at a dose of 200 and 400 mg/kg, per os, during 10 days. Mildronate is inhibitor of carnitine-dependent metabolism of fatty acids affecting at the step of gamma-butyrobetaine turnover into carnitine. The drug inhibitory influence studied appears to be realized via activation of the glycolytic pathway of glucose metabolism specific for inhibitors of beta-oxidation.
Shutenko
Zh V
ZhV
Meĭrena
D V
DV
Kalvin'sh
I Ia
IIa
Lukevits
E Ia
EIa
D020155:3-Hydroxybutyric Acid; D000818:Animals; D004357:Drug Synergism; D005947:Glucose / Q000494:pharmacology*; D006885:Hydroxybutyrates / Q000097:blood; D007657:Ketone Bodies / Q000037:antagonists & inhibitors*; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D010084:Oxidation-Reduction; D051381:Rats
D006885:Hydroxybutyrates; D007657:Ketone Bodies; D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate; D005947:Glucose; D020155:3-Hydroxybutyric Acid
Potentsirovanie antiketogennogo deĭstviia ékzogennoĭ gliukozy s pomoshch'iu novogo ingibitora beta-okisleniia mildronata--3-(2,2,2-trimetilgidraziniĭ)propionata.