Effects of intravenous and aerosolized arachidonic acid on alveolar epithelial permeability in rabbits.
To determine whether arachidonic acid (AA) alters alveolar epithelial permeability, we studied the effect of both continuous intravenous and aerosolized AA on clearance of [99m]Tc-DTPA from lung to blood in rabbits. Although intravenous AA increased prostacyclin production and aerosolized AA decreased systemic blood pressure, neither continuous intravenous nor aerosolized AA augmented alveolar epithelial permeability.
Stevenson
J L
JL
Division of Respiratory Sciences, University of Arizona College of Medicine, Tucson 85724.
Quan
S F
SF
Witten
M L
ML
Hall
J N
JN
Roseberry
H R
HR
McNeill
G C
GC
Lemen
R J
RJ
D000336:Aerosols; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005260:Female; D007262:Infusions, Intravenous; D008297:Male; D010539:Permeability; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics
D000336:Aerosols; D001095:Arachidonic Acids; D016718:Arachidonic Acid; D016284:Technetium Tc 99m Pentetate