title: Effect of fleroxacin and ciprofloxacin on the formation of human mature colonies of healthy donor versus transplanted hemopoietic progenitor cells.
abstract: The effect of fleroxacin and ciprofloxacin on hemopoietic progenitor cells was tested in vitro. Cryopreserved bone marrow samples from 5 patients with acute myeloid leukemia who underwent bone marrow transplantation as well as samples from the respective donors were investigated in parallel. Regarding burst and/or colony formation by erythroid, neutrophil and macrophage precursors, no significant differences were detected with donor and transplanted bone marrows between control cultures and cultures containing 100 mg/l fleroxacin, while 100 mg/l ciprofloxacin inhibited cell proliferation completely. At 50 and 10 mg/l ciprofloxacin had a 50% and no inhibitory effect, respectively.
authors.affiliation: Pharma Clinical Research, F. Hoffmann-La Roche Ltd. Basel, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Kissling
authors.forename: C
authors.initials: C
authors.lastname: Herzog
authors.forename: B
authors.initials: B
authors.lastname: Speck
mesh_terms: D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003114:Colony-Forming Units Assay; D016576:Fleroxacin; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans
chemical_list: D002939:Ciprofloxacin; D016576:Fleroxacin