Effect of an oral adsorbent (AST-120) in rats with daunomycin-induced chronic renal failure.
The effect of an oral adsorbent (AST-120) was examined in rats with daunomycin-induced chronic renal failure. Sixteen pairs of daunomycin rats which had similar levels of proteinuria at 4 weeks after being injected with daunomycin were selected. One rat of each pair served as a control and was fed on a standard diet, while the other rats were fed on a diet containing AST-120. The blood creatinine and blood urea nitrogen (BUN) were significantly lower in the rats fed with AST-120 than in the controls. Moreover, the life span of the rats fed with AST-120 was significantly prolonged as compared to that of the control rats. These findings suggest that oral administration of AST-120 may help to prevent rapid deterioration of renal function in experimental chronic renal failure induced by daunomycin in rats.
Shimizu
K
K
Aichi Prefectural University, Nagoya, Japan.
Maeda
K
K
Shibata
M
M
Ise
M
M
Sugano
M
M
Uehara
Y
Y
D000284:Administration, Oral; D000818:Animals; D002244:Carbon / Q000008:administration & dosage / Q000627:therapeutic use*; D003630:Daunorubicin; D005260:Female; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000188:drug therapy*; D010087:Oxides / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D010087:Oxides; D002244:Carbon; C040896:AST 120; D003630:Daunorubicin