Synthesis and antibacterial activity of new C-10 quinolonyl-cephem esters.
A series of cephalosporins derived from cephalothin containing an ester-linked quinolonyl substituent at the C-10 position (C-10 quinolonyl-cephem esters) has been prepared and evaluated for in vitro antibacterial activity. The C-10 quinolonyl-cephem esters exhibited a broadened spectrum of activity when compared with cephalothin and the corresponding quinolones, including activity against beta-lactamase-producing bacteria.
Demuth
T P
TP
Norwich Eaton Pharmaceuticals, Inc., Procter & Gamble Company, Norwich, New York 13815.
White
R E
RE
Tietjen
R A
RA
Storrin
R J
RJ
Skuster
J R
JR
Andersen
J A
JA
McOsker
C C
CC
Freedman
R
R
Rourke
F J
FJ
D001419:Bacteria / Q000187:drug effects*; D002512:Cephalothin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D004952:Esters; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects
D004952:Esters; D011804:Quinolines; D002512:Cephalothin