title: Differential migration of T and B cells during an acute inflammatory response.
abstract: Inflammation in the liver and mammary glands of sheep caused by challenge infection with Taenia hydatigena or infusion of killed Staphylococcus aureus, respectively were characterized by the recruitment of both T and B cells. The patterns of migration of these two major lymphocyte subpopulations were distinctly different. While T cells seemed to migrate out of existing, flat endothelium-lined blood vessels resulting in a diffuse distribution at the sites of inflammation, B cells were characteristically present as clusters of tightly packed cells at restricted sites in the inflamed tissue. Within these B cell clusters distinct capillary vessels lined with plumb endothelial cells were always present suggesting that they were the sites of intense migration of B cells originating from the draining lymph nodes. These results indicate differential regulation of adhesion molecules on B and T cells and/or their ligands on endothelium during acute inflammatory reactions.
authors.affiliation: Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: E
authors.initials: E
authors.lastname: Meeusen
authors.forename: C S
authors.initials: CS
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Brandon
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology; D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D002465:Cell Movement; D005260:Female; D007249:Inflammation / Q000276:immunology*; D008099:Liver / Q000473:pathology; D008321:Mammary Glands, Animal / Q000473:pathology; D012756:Sheep; D013203:Staphylococcal Infections / Q000276:immunology; D013601:T-Lymphocytes / Q000502:physiology*; D013622:Taeniasis / Q000276:immunology