A gene for limb-girdle muscular dystrophy maps to chromosome 15 by linkage.
Limb-girdle muscular dystrophy (LGMD) is inherited as a monogenic, autosomal recessive trait. A genetically homogeneous group of families from the Isle of La Réunion, comprising individuals at high risk for this disorder, was systematically analysed using a panel of 85 polymorphic markers spanning approximately 30% of the human genome. Linkage was detected between the LGMD gene and the marker D15S25, uncovered with the probe pTHH114 and restriction enzyme RsaI (lod score = 5.52 at a 0 = 0.0), localising this gene onto chromosome 15. Such a lod score corresponds to odds of 3.3 x 105 in favor of linkage versus absence of linkage. Additional families from other populations will need to be examined before the role of this newly identified locus can be understood.
Beckmann
J S
JS
Centre d'Etude du Polymorphisme humain, Paris.
Richard
I
I
Hillaire
D
D
Broux
O
O
Antignac
C
C
Bois
E
E
Cann
H
H
Cottingham
R W
RW
Feingold
N
N
Feingold
J
J
D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D006801:Humans; D008126:Lod Score; D009136:Muscular Dystrophies / Q000235:genetics*; D010139:Pacific Islands; D011110:Polymorphism, Genetic / Q000235:genetics