[Changes in the secretion of gonadoliberin, gonadotropins, and ovarian hormones in rats under chronic exposure to low concentrations of methylmethacrylate].
Chronic influence of small concentrations of methylmethacrylate in inhalations (at the level of a maximum permissible dose of 50 mg/m3 and in its 10-fold excess) after short-term enhancement of the hypothalamo-hypophyseo-gonad system (in one month after exposure to a dose at maximum permissible concentration) is quickly followed by suppression of its function. The use of methylmethacrylate for 4 months revealed a decrease in ovarian mass, the blood level of progesterone and a rise of secretion of FSH and LH with a simultaneous decrease in the level of gonad-releasing hormone in the mediobasal hypothalamic structures. It indicates primary gonad damage of the reproductive system and preservation of a normal reaction of the hypothalamohypophyseal factor, responding by activation on the feedback principle. In 4 months a high embryotoxic and teratogenic effect of methylmethacrylate was observed.
Stepanov
M G
MG
Altukhov
V V
VV
Senichenkova
I N
IN
D000818:Animals; D005246:Feedback / Q000187:drug effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006062:Gonadotropins / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007986:Luteinizing Hormone / Q000378:metabolism; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000633:toxicity*; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013723:Teratogens; D013997:Time Factors
D006062:Gonadotropins; D008768:Methylmethacrylates; D013723:Teratogens; D020366:Methylmethacrylate; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Izmeneniia sekretsii gonadoliberina, gonadotropinov i gormonov iachnikov u krys pod vliianiem khronicheskogo vozdeĭstviia malykh kontsentratsiĭ metilmetakrilata.