[Three cases of minocycline-induced pneumonitis].
All three patients complained of cough, fever and dyspnea. Their chest X-ray films revealed interstitial changes such as Kerley B lines. The results of lymphocyte stimulation tests were all negative for Minocycline (MINO), whereas the provocation tests were all positive in three cases. The onsets of symptoms appeared 7, 12 and 9 hours after administration of MINO respectively, which suggested type III allergy in terms of the latency period. In cases No. 1 and No. 3, lung tissue specimens obtained by transbronchial biopsy showed findings of mild acute eosinophilic pneumonia. The bronchoalveolar lavage fluid of case No. 3 showed eosinophilia. On diagnosing MINO-induced pneumonitis, the lymphocyte stimulation test is not always beneficial, whereas the provocation test is supposed to be a safe and sure method.
Shintani
H
H
Department of Internal Medicine, Inami Kohsei Hospital, Toyama, Japan.
Minami
S
S
Iwabuchi
K
K
Johkaji
Y
Y
Hashimoto
A
A
Noumi
I
I
Fujimura
M
M
Matsuda
T
T
Kitagawa
M
M
D000328:Adult; D000368:Aged; D001980:Bronchi / Q000473:pathology; D001985:Bronchial Provocation Tests; D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology; D004802:Eosinophilia / Q000473:pathology; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D011014:Pneumonia / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology
D008911:Minocycline