The rise of serum creatinine levels during labor.
Serum creatinine, blood urea nitrogen and creatine phosphokinase were measured in 32 women during the last 3 weeks of pregnancy and, in a further 39 women, during and after labor. The serum creatinine increased from 61.9 +/- 0.9 to 69.8 +/- 1.8 mumol/l (mean +/- SEM) (P less than 0.05) in the third stage of labor and returned to normal by 72 h after delivery. The muscle creatine phosphokinase increased from 54 +/- 7 to 77 +/- 9.9 units (P less than 0.05) during the third stage and remained high (87 +/- 13.3 units) 72 h later. We conclude that these changes are due to muscle contraction and injury during delivery.
Weissberg
N
N
Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
Shemesh
O
O
Schwartz
G
G
Brisk
R
R
Eylath
U
U
Abraham
A S
AS
D000293:Adolescent; D000328:Adult; D001806:Blood Urea Nitrogen; D003402:Creatine Kinase / Q000097:blood; D003404:Creatinine / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007743:Labor, Obstetric / Q000097:blood*; D011247:Pregnancy; D012016:Reference Values; D012079:Renal Circulation / Q000502:physiology*
D003404:Creatinine; D003402:Creatine Kinase