Patterning in the regeneration of electroreceptors in the fin of Kryptopterus.
The influence of the target tissue on afferent nerve regeneration was studied in the adult glass catfish, Kryptopterus. In this fish, electroreceptors in the anal fin are distributed in a characteristic pattern in the proximal part of the fin and are absent in the distal portion of the fin. We tested whether axons were more likely to induce electroreceptors in certain regions of fin epidermis than in others. We rotated fin transplants so that the location of the degenerating electroreceptors was altered with respect to the regenerating axons in the host tissue dorsal to the fin. The effects of these rotations were observed in the living animal with differential interference contrast optics over a period of 10 weeks. When transplants were reversed rostrocaudally, new electroreceptors formed in the caudal half of the interradial zone, where degenerating electroreceptors were at the time of transplantation. When transplants were rotated so that the dorsoventral and rostrocaudal axes were reversed, some new receptors formed in the old target site regions that were located in the caudal interradial zones (in the distal half of the graft with respect to the host). Regenerating axons reached these regions of the transplant by taking unusual routes around the electroreceptor-free regions of fin. Very few electroreceptors formed in the distal/caudal or proximal/caudal interradial quadrants of grafts where the original orientation of the tissue was maintained. We suggest that old target sites have a neurotropic influence on the regenerating afferent axons and discuss the possibility that the distal fin epidermis is not as permissive to electroreceptor formation as proximal fin epidermis.
Bever
M M
MM
Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907.
Borgens
R B
RB
D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D002397:Catfishes / Q000502:physiology*; D004594:Electrophysiology; D009416:Nerve Regeneration; D011984:Sensory Receptor Cells / Q000502:physiology* / Q000648:ultrastructure; D012867:Skin / Q000294:innervation