[The mutagenicity of a new multicomponent vaccine made from the antigens of Klebsiella pneumoniae, Staphylococcus aureus, Proteus vulgaris and Escherichia coli].
Inactivated bacterial vaccine, containing K. pneumoniae, S. aureus, P. vulgaris and E. coli antigenic complexes were tested for mutagenicity in the test described by Ames et al. and in vivo, in experiments on mice. In Salmonella typhimurium cells, strain TA-98 and TA-100, the preparation (5-75 mg/ml) did not increase the frequency of reversions and histidine-independence either in direct experiments or after metabolic activation with rat liver homogenate. In experiments on mice the vaccine (3.3 mg/kg and 33 mg/kg) did not induce chromosomal anomalies in spermatogonia. In all experiments the mutagens used for positive control produced a mutagenic effect.
Volgareva
G M
GM
Tolcheev
Iu D
IuD
Egorova
N B
NB
Mansurova
N L
NL
Silin
A M
AM
Anpilogova
O R
OR
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations / Q000235:genetics; D004338:Drug Combinations; D004926:Escherichia coli / Q000276:immunology*; D005798:Genes, Bacterial / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000276:immunology*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation / Q000187:drug effects; D011514:Proteus vulgaris / Q000276:immunology*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013093:Spermatogonia / Q000187:drug effects; D013211:Staphylococcus aureus / Q000276:immunology*
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D004338:Drug Combinations; D009153:Mutagens
Issledovanie mutagennosti novoĭ polikomponentnoĭ vaktsiny iz antigenov Klebsiella pneumoniae, Staphylococcus aureus, Proteus vulgaris i Escherichia coli.