The effects of thiamin on lead metabolism: whole body retention of lead-203.
The effects of thiamin on the whole body retention of led were evaluated in CD-1 mice treated intragastrically or intraperitoneally while exposed to a single dose of lead acetate (100 micrograms) containing 100 mu Ci lead-203. They were administered thiamin (25 or 50 mg/kg body wt.), calcium ethylenediamine tetraacetic acid (CaEDTA) (50 mg/kg body wt.) or their combination in pretreatment or posttreatment regimens for 13 days. Both pre- and posttreatment with thiamin reduced the lead retention compared to the untreated lead-exposed mice, although the different patterns of lead retention were observed. The combined pretreatment (thiamin 50 mg/kg and CaEDTA) and the CaEDTA treatment alone reduced the whole body retention of lead most effectively. Thiamin, CaEDTA and the combined treatments decreased the absorption of lead-203 and the biological half-life of retained lead-203 following oral or intraperitoneal lead exposure. The reduced absorption and enhanced excretion of lead associated with thiamin administration may have therapeutic application for the treatment of lead poisoning.
Kim
J S
JS
Department of Veterinary Physiological Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
Hamilton
D L
DL
Blakley
B R
BR
Rousseaux
C G
CG
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D004492:Edetic Acid / Q000494:pharmacology / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D007854:Lead / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D007855:Lead Poisoning / Q000378:metabolism / Q000517:prevention & control; D007856:Lead Radioisotopes; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013831:Thiamine / Q000494:pharmacology* / Q000627:therapeutic use
D007856:Lead Radioisotopes; D007854:Lead; D004492:Edetic Acid; D013831:Thiamine