Molecular cloning and primary structure of squid (Loligo forbesi) rhodopsin, a phospholipase C-directed G-protein-linked receptor.
The sequence of squid (Loligo forbesi) rhodopsin was determined by protein and cDNA sequencing. The protein has close similarity to octopus rhodopsin, having an N-terminal region (residues 1-340) which resembles other guanine-nucleotide-binding protein (G-protein)-linked receptors and a repetitive proline-rich C-terminus (residues 340-452). Comparison of the sequence of squid rhodopsin with those of other members of the G-protein-linked receptor superfamily reveals features which we predict to have both structural and functional importance.
Hall
M D
MD
Department of Biochemistry and Molecular Biology, University of Leeds, U.K.
Hoon
M A
MA
Ryba
N J
NJ
Pottinger
J D
JD
Keen
J N
JN
Saibil
H R
HR
Findlay
J B
JB
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular / Q000379:methods; D049832:Decapodiformes; D019204:GTP-Binding Proteins / Q000378:metabolism; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D010957:Plasmids; D011487:Protein Conformation; D015183:Restriction Mapping; D012243:Rhodopsin / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D010738:Type C Phospholipases / Q000378:metabolism
D015345:Oligonucleotide Probes; D012243:Rhodopsin; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins