[The use of antioxidants in the complex therapy of patients with infiltrating pulmonary tuberculosis].
Clinical and laboratory investigations examined the possibility of a lower load of antibacterial drugs (ABD) in combination with the two antioxidants, alpha-tocopherol and sodium thiosulfate, in combined therapy of patients with infiltrative pulmonary tuberculosis. Higher efficacy of two ABDs supplemented by two antioxidants than three or more ABDs was evidenced by a shorter period of sputum negativity (1.6 +/- 0.26 and 2.7 +/- 0.27 months; p less than 0.01) and higher rates of cavity closure (95.6 +/- 4.3 and 63.2 +/- 6.7%; p less than 0.05).
Starostenko
E V
EV
Dolzhanskiĭ
B M
BM
Salpagarov
A M
AM
Levchenko
T N
TN
D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D008854:Microscopy, Electron; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000648:ultrastructure; D013183:Sputum / Q000382:microbiology; D013885:Thiosulfates / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D013885:Thiosulfates; D014810:Vitamin E; C017717:sodium thiosulfate
Primenenie antioksidantov v kompleksnom lechenii bol'nykh infil'trativnym tuberkulezom legkikh.