Quantitative evaluation of octadecaneuropeptide-like immunoreactivity in hippocampus, cortex and cerebellum of long-term isolated male Wistar rats.
Quantitative evaluation of octadecaneuropeptide-like immunoreactivity (ODN-Li) was carried out in hippocampus, cortex and cerebellum of group-reared or three month isolated male Wistar rats, whether muricidal or not. ODN-Li was lower in cortex and cerebellum of isolated animals, (mainly in muricidal) than of group-reared ones. A similar trend was apparent in the hippocampus. No significant differences were observed between muricidal and non-muricidal animals. The results are discussed in terms of the involvement of the endogenous ligands of the GABA-benzodiazepine receptor complex in the integrations related to mood and behaviour.
Miachon
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Inserm U 171/CNRS URA 1195, Pavillon 4H, Centre Hospitalier Lyon Sud, France.
Tonon
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MC
Vaudry
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Buda
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M
D000818:Animals; D001522:Behavior, Animal; D001923:Brain Chemistry; D002531:Cerebellum / Q000737:chemistry*; D002540:Cerebral Cortex / Q000737:chemistry*; D026261:Diazepam Binding Inhibitor; D006624:Hippocampus / Q000737:chemistry*; D008297:Male; D009479:Neuropeptides / Q000032:analysis* / Q000276:immunology; D010446:Peptide Fragments; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012934:Social Isolation
D026261:Diazepam Binding Inhibitor; D009479:Neuropeptides; D010446:Peptide Fragments; C067529:diazepam binding inhibitor (33-50)