title: MRI findings in boys with specific language impairment.
abstract: Magnetic resonance imaging scans of specifically language-impaired (SLI) boys were examined to determine whether atypical cerebral findings could be documented in children whose primary deficits were in language skills. Clinical examination of the scans failed to reveal any visually obvious lesions or abnormalities. In contrast, measurement of the scans revealed atypical perisylvian asymmetries in most of these subjects. The distribution of perisylvian asymmetries in SLI subjects was significantly different from the distribution in controls (p less than .01). Measurement of other brain regions revealed that extraperisylvian areas were occasionally deviant in individual SLI subjects; but no one region was consistently deviant across the SLI group. Thus, only atypical perisylvian asymmetries were linked to the language disorder. These neuroanatomical findings suggest that a prenatal alteration of brain development underlies specific language impairment.
authors.affiliation: Child Language Laboratory, University of Arizona, Tucson 85702.
authors.forename: E
authors.initials: E
authors.lastname: Plante
authors.forename: L
authors.initials: L
authors.lastname: Swisher
authors.forename: R
authors.initials: R
authors.lastname: Vance
authors.forename: S
authors.initials: S
authors.lastname: Rapcsak
mesh_terms: D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D002540:Cerebral Cortex / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004292:Dominance, Cerebral / Q000502:physiology; D006801:Humans; D007805:Language Development Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D009483:Neuropsychological Tests; D012307:Risk Factors