Cognitive enhancing actions of PD123177 detected in a mouse habituation paradigm.
The anxiolytic-like and cognitive enhancing potential of PD123177, a non-peptide with selectivity for the angiotensin II-2 receptor recognition site, was assessed in a mouse light/dark aversion test and habituation test, respectively. PD123177 (0.01 ng kg-1 to 1.0 mg kg-1 i.p.) failed to alter the behavioural repertoire of animals in the light/dark aversion test. In contrast, daily administration of PD123177 (10.0 ng kg-1 i.p. b.d.) enhanced the performance of mice in a habituation test. In addition, PD123177 overcame the cognitive impairment induced by the administration of scopolamine (0.25 mg kg-1 i.p.). Such findings indicate for the first time a functional role for the angiotension II-2 receptor and further implicate the angiotensin system in the modulation of cognitive processes.
Barnes
N M
NM
Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, West Yorkshire, UK.
Costall
B
B
Kelly
M E
ME
Murphy
D A
DA
Naylor
R J
RJ
D000804:Angiotensin II; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008027:Light; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011725:Pyridines / Q000494:pharmacology*; D013268:Stimulation, Chemical
D057911:Angiotensin Receptor Antagonists; D007093:Imidazoles; D011725:Pyridines; D000804:Angiotensin II; C066253:PD 123177