Megakaryoblastic leukemia with an N-ras mutation and late acquisition of a Philadelphia chromosome.
A patient is described with de novo acute non-lymphocytic leukemia of megakaryoblastic lineage with tri-lineage myelodysplasia. This patient was studied cytogenetically and using molecular genetic techniques throughout her clinical course. She had an N-ras mutation at diagnosis which persisted despite a bone marrow transplant, and acquired a Philadelphia chromosome associated with a P190 BCR-ABL transcript at clinical relapse 3 months post-transplantation.
Vandenberghe
E
E
Centre for Human Genetics, University of Leuven, Belgium.
Martiat
P
P
Baens
M
M
Stul
M
M
Ferrant
A
A
Cuneo
A
A
Cassiman
J J
JJ
Mecucci
C
C
Van den Berghe
H
H
D000328:Adult; D001483:Base Sequence; D002871:Chromosome Banding; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D011905:Genes, ras; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics* / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000737:chemistry; D016133:Polymerase Chain Reaction; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D013997:Time Factors
D009841:Oligonucleotides; D016044:Fusion Proteins, bcr-abl; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)