Effects of polydextrose on serum lipids, lipoproteins, and apolipoproteins in healthy subjects.
The subjects were 61 healthy volunteers who received 15 gm of polydextrose daily for two months. A significant increase in the incidence of soft feces and diarrhea and in the volume of feces was reported during polydextrose treatment. These had returned to normal one month after treatment. Serum levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol did not change during treatment. Levels of apolipoprotein (apo) A-I and A-II were significantly lowered at one month and high-density lipoprotein cholesterol (HDL-C) and apo A-I were significantly decreased at two months; these returned to normal after treatment. Levels of HDL2-C decreased and HDL3-C levels increased significantly during treatment. The results indicate that polydextrose selectively affected the metabolism of HDL and its major proteins, apo A-I and A-II.
Saku
K
K
Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
Yoshinaga
K
K
Okura
Y
Y
Ying
H
H
Harada
R
R
Arakawa
K
K
D000328:Adult; D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001053:Apolipoproteins / Q000097:blood*; D001054:Apolipoproteins A / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D005936:Glucans / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001053:Apolipoproteins; D001054:Apolipoproteins A; D005936:Glucans; D008055:Lipids; D008074:Lipoproteins; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; C033375:polydextrose