Parvalbumin-immunoreactive neurons in the cortex in Pick's disease.
Parvalbumin (a calcium-binding protein)-immunoreactive (PV-Ir) neurons in the cerebral cortex were examined in 20 postmortem brains obtained from elderly controls and patients with Pick's disease (PD). The type of PV-Ir neurons and their distribution in control and PD brains were similar. The number of PV-Ir neurons in PD brains did not differ significantly from that in the control brains either. These findings suggested that PV-Ir neurons in the cortex are not affected in PD brains. A significant loss of PV-Ir neurons has already been reported in brains obtained from patients with Alzheimer-type dementia (ATD), and the present results suggest the possibility that the damage of PV-Ir neurons might be comparatively selective for ATD brains.
Arai
H
H
Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.
Noguchi
I
I
Makino
Y
Y
Kosaka
K
K
Heizmann
C W
CW
Iizuka
R
R
D000368:Aged; D002540:Cerebral Cortex / Q000737:chemistry*; D003704:Dementia; D005625:Frontal Lobe / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009474:Neurons / Q000737:chemistry; D010320:Parvalbumins / Q000032:analysis*; D012016:Reference Values; D013702:Temporal Lobe / Q000737:chemistry
D010320:Parvalbumins