title: Increase of plasma tissue-plasminogen activator antigen levels after induced abortion.
abstract: We previously reported that plasma thrombotic activity is transiently increased immediately after induced abortion. However, changes in the fibrinolytic system have not yet been studied. Plasma tissue-plasminogen activator (t-PA) antigen levels were studied before and after abortion induced during the first trimester of pregnancy. Compared with the preoperative level (1.68 +/- 0.15 ng/ml), t-PA level was significantly increased (2.78 +/- 0.55 ng/ml, p less than 0.01) 15 min after the induced abortion, while it almost returned to the preoperative values (2.09 +/- 0.40 ng/ml) 2h later. This finding suggests that fibrinolytic activity is transiently increased immediately after the induced abortion, acting as a defense mechanism against thrombosis.
authors.affiliation: Department of Obstetrics and Gynecology, Kumamoto University Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Yoshimura
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: N
authors.initials: N
authors.lastname: Kawasaki
authors.forename: H
authors.initials: H
authors.lastname: Okamura
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D010959:Tissue Plasminogen Activator / Q000097:blood*
chemical_list: D010959:Tissue Plasminogen Activator