title: Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile, Peumus boldus.
abstract: Dried hydro-alcoholic extract of Peumus boldus (Monimiaceae) has been evaluated for hepatoprotective, choleretic and anti-inflammatory effects in mice and rats, in order to validate or to invalidate traditional therapeutic indications. This extract exerted a significant hepatoprotection of tert-butyl hydroperoxide-induced hepatotoxicity in isolated rat hepatocytes (in vitro technique) by reducing the lipid peroxidation and the enzymatic leakage of LDH; this in vitro efficacy was reinforced by a significant hepatoprotection on CCl4-induced hepatotoxicity in mice (in vivo technique), the plant extract reducing the enzymatic leakage of ALAT. Boldine, the main alkaloid of P. boldus appears to be implicated in this hepatoprotective activity. Choleretic effects, often mentioned in traditional indications, have not been confirmed in rats. Finally, significant and dose-dependent anti-inflammatory effects were obtained on an acute inflammatory process (carrageenan-induced edema test in rats). Boldine does not appear to be involved in such properties.
authors.affiliation: Laboratoire de Pharmacognosie, Université de Metz, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Lanhers
authors.forename: M
authors.initials: M
authors.lastname: Joyeux
authors.forename: R
authors.initials: R
authors.lastname: Soulimani
authors.forename: J
authors.initials: J
authors.lastname: Fleurentin
authors.forename: M
authors.initials: M
authors.lastname: Sayag
authors.forename: F
authors.initials: F
authors.lastname: Mortier
authors.forename: C
authors.initials: C
authors.lastname: Younos
authors.forename: J M
authors.initials: JM
authors.lastname: Pelt
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification; D002677:Chile; D002756:Cholagogues and Choleretics; D006505:Hepatitis / Q000188:drug therapy*; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D010545:Peroxides; D010946:Plants, Medicinal / Q000032:analysis*; D020122:tert-Butylhydroperoxide
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002756:Cholagogues and Choleretics; D010545:Peroxides; D020122:tert-Butylhydroperoxide