Is thrombopoietin interleukin 6?
Recent data concerning to ability of interleukin 6 (IL-6) to stimulate platelet production have raised the possibility that platelet production is not specifically regulated by a unique feedback mechanism, but is part of a network encompassing several hemopoietic growth factors. Hypotheses are presented about the nature of thrombopoietin, its relationship to known growth factors, especially IL-6, and the specificity of a thrombopoietic response following change in the circulating platelet mass.
Williams
N
N
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
D006133:Growth Substances / Q000494:pharmacology; D006410:Hematopoiesis; D006801:Humans; D015850:Interleukin-6 / Q000494:pharmacology / Q000502:physiology*; D008533:Megakaryocytes / Q000166:cytology; D013926:Thrombopoietin / Q000502:physiology*
D006133:Growth Substances; D015850:Interleukin-6; D013926:Thrombopoietin