title: SPECT and MR imaging in herpes simplex encephalitis.
abstract: Two cases of necrotizing herpes simplex encephalitis (HSE) were investigated with 99mTc-hexamethylpropyleneamineoxime (HMPAO) SPECT and MR. The clinical course was compared with the neuroimaging results. In the acute stage, the increased HMPAO uptake matched the MR hyperintense signal in the limbic temporal lobe and in the basal ganglia. Protracted inflammation was accompanied by persistently high HMPAO uptake. The sequelae of HSE were characterized by decreased HMPAO uptake and postnecrotic widening of the temporal horns. The "limbic" pattern recognized in both SPECT and MR reflects the basic pathophysiology and neuropathology of HSE. Both methods may be useful in the diagnosis and follow-up of HSE.
authors.affiliation: Abteilung für Neuronuklearmedizin, Neuronuklearmedizin der Neurologischen Universitätsklinik Wien, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Schmidbauer
authors.forename: I
authors.initials: I
authors.lastname: Podreka
authors.forename: D
authors.initials: D
authors.lastname: Wimberger
authors.forename: W
authors.initials: W
authors.lastname: Oder
authors.forename: G
authors.initials: G
authors.lastname: Koch
authors.forename: S
authors.initials: S
authors.lastname: Wenger
authors.forename: G
authors.initials: G
authors.lastname: Goldenberg
authors.forename: S
authors.initials: S
authors.lastname: Asenbaum
authors.forename: L
authors.initials: L
authors.lastname: Deecke
mesh_terms: D003287:Contrast Media; D004660:Encephalitis / Q000175:diagnosis*; D005260:Female; D019786:Gadolinium DTPA; D006561:Herpes Simplex / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D010091:Oximes; D004369:Pentetic Acid; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D004369:Pentetic Acid; D019786:Gadolinium DTPA