title: [The effect of metabolites of the propionate pathway on the oxidative activity of liver mitochondria].
abstract: Methylmalonate and propionate, the major metabolites of the propionate pathway of fatty and amino acid metabolism used at 1-4 mM cause selective inhibition of succinate and palmitoyl carnitine oxidation in liver mitochondria. Methylmalonate is more specific towards succinate, whereas propionate--towards palmitoyl carnitine oxidation. Methylmalonate is transported to mitochondria at a high rate with no effect on succinate transport. Being injected intramusculary methylmalonate has no inhibiting effect on the oxidative activity of mitochondria but is able to activate succinate and palmitoyl carnitine oxidation. The inhibiting effect of propionate on palmitoyl carnitine oxidation is a long-term one. Injections of these metabolites precursors, isoleucine, methionine and valine, produce an activating effect on succinate oxidation. Thus, propionate pathway metabolites may participate in the regulation of lipid-carbohydrate metabolism.
authors.forename: N I
authors.initials: NI
authors.lastname: Fedotcheva
authors.forename: N N
authors.initials: NN
authors.lastname: Gessler
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Bykhovskiĭ
authors.forename: M N
authors.initials: MN
authors.lastname: Kondrashova
mesh_terms: D000818:Animals; D007532:Isoleucine / Q000378:metabolism; D008314:Malonates / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D010172:Palmitoylcarnitine / Q000378:metabolism; D011422:Propionates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012402:Rotenone / Q000494:pharmacology; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D014633:Valine / Q000378:metabolism
chemical_list: D008314:Malonates; D011422:Propionates; D013386:Succinates; D012402:Rotenone; D007532:Isoleucine; D010172:Palmitoylcarnitine; D019802:Succinic Acid; D008715:Methionine; C005230:methyl malonate; D014633:Valine
vernacular_title: Vliianie metabolitov propionatnogo puti na okislitel'nuiu aktivnost' mitokhondriĭ pecheni.