title: [Orthotopic liver transplantation at the Island Hospital. Initial experiences 1985-1990].
abstract: Between 1985 and 1990 22 orthotopic liver transplantations (OLT) were realized in 19 patients. Active infection and diffuse splanchnic venous thrombosis were the only contra-indications to the intervention. Sixteen patients were transplanted electively; three had to be retransplanted urgently. Three patients had an urgent primary transplant. The incidence of surgical complications related to liver implantation was fair. One patient (5%) developed a late portal vein thrombosis; another patient (5%) had to be retransplanted because of hepatic artery thrombosis. All patients presented one or more major postoperative complications. All, but one, patients had a rejection of the allograft; five of them needed treatment with mono- or polyclonal antilymphocytic sera to reverse the rejection. One patient was retransplanted because of a hyperacute rejection. The six-month survival in this series is 68.5% (13 of 18 patients); one patient died 7 months post-OLT due to a neurological complication of her Wilson disease. Quality of life (from 6 to 64 months post-OLT) is excellent in the 12 long-term survivors. This small experience of the Bernese transplantation program shows that liver transplantation is a safe surgical procedure allowing excellent quality of life in a majority of patients.
authors.affiliation: Klinik für Viszerale und Transplantationschirurgie, Inselspital Bern.
authors.forename: J P
authors.initials: JP
authors.lastname: Lerut
authors.forename: P
authors.initials: P
authors.lastname: Gertsch
authors.forename: P J
authors.initials: PJ
authors.lastname: Luder
authors.forename: A
authors.initials: A
authors.lastname: Zimmermann
authors.forename: E A
authors.initials: EA
authors.lastname: Dijkhuis
authors.forename: H U
authors.initials: HU
authors.lastname: Rothen
authors.forename: B
authors.initials: B
authors.lastname: Ott
authors.forename: U
authors.initials: U
authors.lastname: Nydegger
authors.forename: F
authors.initials: F
authors.lastname: Horber
authors.forename: H U
authors.initials: HU
authors.lastname: Fisch
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology; D006501:Hepatic Encephalopathy / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007165:Immunosuppression Therapy; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation / Q000276:immunology / Q000379:methods* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D012086:Reoperation
vernacular_title: Orthotope Lebertransplantation am Inselspital. Erste Erfahrungen während der Periode 1985-1990.