title: Transcranial Doppler: response of cerebral blood-flow velocity to carbon dioxide in anaesthetized children.
abstract: To determine the effect of carbon dioxide on the cerebral circulation in anaesthetized infants and children, 13 healthy children, ASA physical status I or II, between three months and seven years of age and scheduled for urologic surgery, were studied. Anaesthesia was induced with thiopentone and vecuronium. After tracheal intubation, anaesthesia was maintained with 70 per cent nitrous oxide in oxygen, fentanyl 2 micrograms.kg-1, vecuronium 0.05 mg.kg-1 and 0.8-1.0 per cent end-tidal isoflurane. A caudal block was performed before surgery. Systolic arterial pressure, heart rate, oxygen saturation, temperature, and end-tidal isoflurane were maintained constant. Ventilation was adjusted to achieve an end-tidal PCO2 (PETCO2) of 20 mmHg. The PETCO2 was then randomly adjusted between 20 and 80 mmHg by the addition of carbon dioxide from an exogenous source. Cerebral blood flow velocity increased logarithmically and directly with the PETCO2 (r2 = 0.56). There were no complications associated with the use of transcranial Doppler sonography. These data indicate that CO2 has a direct effect on the velocity of blood in the middle cerebral artery in infants and children anaesthetized with isoflurane.
authors.affiliation: Department of Anaesthesia, Hospital for Sick Children, University of Toronto, Ontario, Canada.
authors.forename: M A
authors.initials: MA
authors.lastname: Pilato
authors.forename: B
authors.initials: B
authors.lastname: Bissonnette
authors.forename: J
authors.initials: J
authors.lastname: Lerman
mesh_terms: D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D001783:Blood Flow Velocity / Q000187:drug effects; D002245:Carbon Dioxide / Q000494:pharmacology*; D002536:Cerebral Arteries / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007385:Intermittent Positive-Pressure Ventilation; D007430:Intraoperative Care; D007442:Intubation, Intratracheal; D011674:Pulse / Q000187:drug effects; D014463:Ultrasonography; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D002245:Carbon Dioxide