title: Treatment with rIFN-gamma has no effect on cardiac allograft rejection.
abstract: The effect of recombinant rat interferon-gamma (rRIFN-gamma) on allograft rejection was studied in two rat heart transplantation models. Recipients were treated with rRIFN-gamma by intraperitoneal or intravenous injection, either by bolus or continuous infusion. Treatment was started after transplantation and continued during a period ranging from 4 to 10 days; dosages varied from 2.5 x 10(2) U/kg/day to 3 x 10(6) U/kg/day. Controls were infused with PBS. Treatment with rRIFN-gamma had no effect on allograft survival, irrespective of the route of administration, the dosage used or the duration of treatment. Higher dosages of rRIFN-gamma induced serious morbidity and mortality. In conclusion, systemic treatment of cardiac allograft recipients with rRIFN-gamma has no effect on graft rejection and is associated with serious toxicity and mortality when high dosages are used.
authors.affiliation: Laboratory for Experimental Surgery, Erasmus University, Rotterdam, The Netherlands.
authors.forename: J N
authors.initials: JN
authors.lastname: Ijzermans
authors.forename: E
authors.initials: E
authors.lastname: Bouwman
authors.forename: R W
authors.initials: RW
authors.lastname: de Bruin
authors.forename: J
authors.initials: J
authors.lastname: Jeekel
authors.forename: R L
authors.initials: RL
authors.lastname: Marquet
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D007371:Interferon-gamma / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D007371:Interferon-gamma