title: Requirement of microfilaments in sorting of actin messenger RNA.
abstract: Specific messenger RNAs (mRNAs) can be sequestered within distinct cellular locations, but little is known about how this is accomplished. The participation of the three major cellular filaments in the localization of actin mRNA was studied in chicken embryo fibroblasts. Movement of actin mRNA to the cell periphery and maintenance of that regionalization required intact microfilaments (composed of actin) but not microtubules or intermediate filaments. The results presented here suggest that actin-binding proteins may participate in mRNA sorting.
authors.affiliation: Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655.
authors.forename: C L
authors.initials: CL
authors.lastname: Sundell
authors.forename: R H
authors.initials: RH
authors.lastname: Singer
mesh_terms: D008841:Actin Cytoskeleton / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D000199:Actins / Q000235:genetics*; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D015638:Cytochalasin D / Q000494:pharmacology; D003703:Demecolcine / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis / Q000187:drug effects / Q000235:genetics*
chemical_list: D000199:Actins; D012333:RNA, Messenger; D015638:Cytochalasin D; D003703:Demecolcine