title: Brain lesions following combined treatment with methotrexate and craniospinal irradiation.
abstract: Eight patients with meningeal seeding by carcinoma or lymphomas were treated with intravenous (i.v.) and/or intrathecal (i.th.) Methotrexate (MTX). Seven patients received additional craniospinal irradiation and in all seven a fatal encephalopathy developed. On the bases of clinical and morphological findings we identified an acute and a delayed form of encephalopathy and concluded that the concurrent administration of Methotrexate and of craniospinal irradiation increases considerably the risk of brain damage.
authors.affiliation: Neurological Tissue Bank, Hospital Clinico I Provincial, University of Barcelona.
authors.forename: F F
authors.initials: FF
authors.lastname: Cruz-Sanchez
authors.forename: J
authors.initials: J
authors.lastname: Artigas
authors.forename: J
authors.initials: J
authors.lastname: Cervos-Navarro
authors.forename: M L
authors.initials: ML
authors.lastname: Rossi
authors.forename: R
authors.initials: R
authors.lastname: Ferszt
mesh_terms: D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology; D001929:Brain Edema / Q000139:chemically induced; D001943:Breast Neoplasms / Q000188:drug therapy / Q000628:therapy; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000009:adverse effects; D003711:Demyelinating Diseases; D003937:Diagnosis, Differential; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D008223:Lymphoma / Q000188:drug therapy / Q000628:therapy; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D001523:Mental Disorders / Q000175:diagnosis; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009336:Necrosis
chemical_list: D008727:Methotrexate