Cross-reactive antibodies induced by a monovalent influenza B virus vaccine.
Influenza viruses related to the markedly antigenically divergent strains B/Yamagata/16/88 and B/Victoria/2/87 are circulating in human populations. Adults develop cross-reacting antibodies against recent and earlier influenza B virus strains after vaccination with B/Yamagata/16/88, probably because of previous influenza B virus infections or immunizations. Vaccines containing B/Yamagata/16/88 should adequately protect adults against B/Victoria/2/87 infections.
Levandowski
R A
RA
Division of Virology, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892.
Gross
P A
PA
Weksler
M
M
Staton
E
E
Williams
M S
MS
Bonelli
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D003429:Cross Reactions; D005260:Female; D006801:Humans; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; D007252:Influenza Vaccines