Antiarthritic effects of glucosamine sulfate studied in animal models.
The antireactive activity of glucosamine sulfate (GS) (CAS 29031-19-4) was tested in the rat in experimental models of subacute inflammation (sponge granuloma and croton oil granuloma), on subacute mechanical arthritis (kaolin arthritis) and in immunological-reactive arthritis and generalized inflammation (adjuvant arthritis). On these models GS was found effective in oral daily doses of 50-800 mg/kg. Tne potency of GS in comparison of that of indometacin used in the same tests as reference substance was found 50-300 times lower. Since, however, the toxicity of indometacin in chronic toxicity experiments is 1000-4000 times larger, the therapeutic margin with regard to prolonged treatments of inflammatory disorders results 10-30 times more favourable for GS than for indometacin. GS can therefore be considered as a drug of choice for prolonged oral treatment of rheumatic disorders.
Setnikar
I
I
Rotta Research Laboratorium S.p.A., Monza, Italy.
Pacini
M A
MA
Revel
L
L
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy; D003436:Croton Oil; D005944:Glucosamine / Q000009:adverse effects / Q000494:pharmacology*; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D007213:Indomethacin / Q000494:pharmacology; D007596:Joints / Q000187:drug effects; D007616:Kaolin; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007616:Kaolin; D003436:Croton Oil; D005944:Glucosamine; D007213:Indomethacin