Serum sialyl-Tn antigen levels in patients with digestive cancers.
Serum levels of sialyl-Tn antigen (STN) were measured using a one-step radioimmunoassay kit in 257 patients with digestive cancers, 121 patients with benign digestive diseases, and in 64 healthy controls. With 45 U/ml regarded as the cutoff value, the positive rates of serum STN in digestive cancers were as follows: pancreas 40.0%, stomach 28.1, colon and rectum 27.8, biliary tract 25.0, liver 7.1, and esophagus 0%. In benign digestive diseases, the positive rate of STN was low (4.1%). In gastric and colorectal cancers, simultaneous measurements of STN and carcinoembryonic antigen (CEA) revealed that the positive rates of STN, CEA, and STN and/or CEA were 28, 42, and 55%, respectively. There was no significant correlation between STN and CEA in these cancers. STN may be a useful serum marker for digestive cancers, especially gastric and colorectal cancers.
Motoo
Y
Y
Department of Internal Medicine, Kanazawa University, Japan.
Kawakami
H
H
Watanabe
H
H
Satomura
Y
Y
Ohta
H
H
Okai
T
T
Makino
H
H
Toya
D
D
Sawabu
N
N
D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood*; D003110:Colonic Neoplasms / Q000097:blood / Q000473:pathology; D004066:Digestive System Diseases / Q000097:blood* / Q000276:immunology; D004067:Digestive System Neoplasms / Q000097:blood* / Q000276:immunology / Q000473:pathology; D006801:Humans; D010190:Pancreatic Neoplasms / Q000097:blood / Q000473:pathology; D012004:Rectal Neoplasms / Q000097:blood / Q000473:pathology; D013274:Stomach Neoplasms / Q000097:blood / Q000473:pathology
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C055491:sialosyl-Tn antigen