[The clinical and immunogenetic characteristics of reactive arthritis in children].
Altogether 52 children suffering from reactive arthritis were placed under observation. In 45 patients arthritis developed after nasopharyngeal infection and was marked by a favourable course with a rapid positive dynamics. 7 children with a history of intestinal infection manifested Reiter's syndrome; in these children arthritis was characterized by a grave and prolonged course and by a high laboratory activity. HLA A10 (RR = 2.7), B27 (RR = 2.5) and DR2 (RR = 2.19) antigen were detected significantly more frequently in ReA patients who suffered nasopharyngeal infection. In children with Reiter's syndrome, the genetic markers of predisposition to the disease were HLA A10 (RR = 5.93) and B27 (RR = 149.1) antigens.
Artamonov
V A
VA
Akhmadi
S
S
Polianskaia
I S
IS
D000293:Adolescent; D001170:Arthritis, Infectious / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D016918:Arthritis, Reactive / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics; D006801:Humans; D008297:Male; D000091402:Prohibitins
D006680:HLA Antigens; C000717331:PHB2 protein, human; D000091402:Prohibitins
Nekotorye klinicheskie i immunogeneticheskie osobennosti reaktivnykh artritov u deteĭ.