Effect of interferon-gamma on B lymphocytes of patients with systemic lupus erythematosus.
We studied the effect of interferon-gamma (IFN-gamma) on B cells in systemic lupus erythematosus (SLE). Low density B cells, which were fractionated on density gradients of Percoll, increased, and high density B cells decreased in number in SLE. Proliferative response of the high density B cells to interleukin 4 was reduced by IFN-gamma in normal controls, but not in SLE. IgG production of whole B cells induced by interleukin 2 or phytohemagglutinin induced T cell factors was enhanced by IFN-gamma in both normal controls and SLE in which activated B cells were thought to be increased in number. Therefore, IFN-gamma may be one of the factors which promote polyclonal B cell activation in SLE.
Funauchi
M
M
Third Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
Sugishima
H
H
Minoda
M
M
Horiuchi
A
A
D001402:B-Lymphocytes / Q000502:physiology*; D002455:Cell Division; D002458:Cell Fractionation; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007371:Interferon-gamma / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000473:pathology*; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology
D007074:Immunoglobulin G; D007376:Interleukin-2; D010835:Phytohemagglutinins; D015847:Interleukin-4; D007371:Interferon-gamma; D011239:Prednisolone