Ultraviolet light induction of peripheral granulocytosis with splenomegaly: protection of mice with topical p-aminobenzoic acid (PABA).
Hairless mice were exposed to UVB irradiation from a Philips T1 12 light source. Mice that were exposed to UV-light and not protected with 5% p-aminobenzoic acid (PABA) showed a significantly higher number of peripheral blood granulocytes (P less than 0.001) and a significantly higher mean weight of both the spleen and the liver (P less than 0.001) than the non-irradiated controls. Light microscopy of the histology of the enlarged liver and spleen showed a proliferation of granulocytes and the reticuloendothelial cells. Treatment with topical PABA during the whole period of UV-exposure prevented the peripheral blood granulocytosis. These protected mice also had a significantly (P less than 0.001) lower mean weight for the liver and spleen than UV-exposed and non-protected mice.
Flindt-Hansen
H
H
Department of Dermatology, Ullevaal University Hospital, Oslo, Norway.
Ebbesen
P
P
D010129:4-Aminobenzoic Acid / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D006098:Granulocytes / Q000528:radiation effects*; D007964:Leukocytosis / Q000209:etiology* / Q000517:prevention & control*; D008099:Liver / Q000473:pathology; D051379:Mice; D008812:Mice, Hairless; D009929:Organ Size / Q000528:radiation effects; D012878:Skin Neoplasms / Q000517:prevention & control; D013154:Spleen / Q000473:pathology; D013163:Splenomegaly / Q000209:etiology*; D014466:Ultraviolet Rays
D010129:4-Aminobenzoic Acid