[Protective effect of misoprostol on the changes of transgastric potential difference induced by aspirin in man].
The measurement of transgastric electric potential difference (DDP) is an easy and reproducible method for evaluation of the gastrotoxicity of aspirin. This randomised crossover placebo-controlled trial in 12 healthy volunteers involved study of the protective effect of misoprostol (Cytotec) against the fall in DDP induced by a gram of aspirin. One day of treatment with misoprostol 200 micrograms morning and evening led to a statistically lower fall in DDP than with the placebo: area under the curve 130 +/- 315 mV.min cf. 589 +/- 465 mV.min (p = 0.012), maximum variation 11.4 +/- 11.3 mV cf. 24.9 +/- 13.2 mV (p = 0.04). This result independent of the antisecretory action of the compound, confirms the protective effect of this prostaglandin analogue against the gastric damage caused by aspirin.
Bergmann
J F
JF
Clinique Thérapeutique (1), Hôpital Lariboisière, Paris.
Simoneau
G
G
Naudin
R
R
Caulin
C
C
Segrestaa
J M
JM
D000328:Adult; D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D016595:Misoprostol
D000897:Anti-Ulcer Agents; D016595:Misoprostol; D000527:Alprostadil; D001241:Aspirin
Etude chez l'homme de l'effet protecteur du misoprostol sur les variations de la différence de potentiel transgastrique induites par l'aspirine.