[Purified sulfur as an agent to relieve the side effects in the radiation therapy of cervical cancer].
The theoretical basis of this work is the development of autosensitization in exposure to ionizing radiation and well-known desensitizing action of sulphuric agents. To reduce clinical manifestations of a reaction to combined radiotherapy 34 women with diagnosis of cervical cancer (stages I and II) were given 0.5-1 g of purified sulphur mixed with 0.25 g of glucose in the morning every 2-3 hours before irradiation, per os; 24 patients received placebo (a mixture of egg powder with glucose), in 21 patients no protective means were used. All 79 patients were given unified adjuvant therapy (polyvitamins, leukogens, folic acid) and diet No 15. A significant decrease in the reaction to therapeutic irradiation was noted in the study group. No side-effects were observed.
Smirnova
O V
OV
Saliev
V P
VP
Klemparskaia
N N
NN
Dobronravova
N N
NN
D000818:Animals; D004285:Dogs; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control*; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D011879:Radiotherapy Dosage; D013455:Sulfur / Q000009:adverse effects / Q000302:isolation & purification / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000532:radiotherapy*
D011837:Radiation-Protective Agents; D013455:Sulfur
Ochishchennaia sera kak sredstvo oslableniia pobochnykh reaktsiĭ pri luchevoĭ terapii raka sheĭki matki.