title: Bezold-Jarisch reflex in postoperative pediatric cardiac surgical patients.
abstract: The Bezold-Jarisch reflex is an inhibitory reflex that originates from the heart, is mediated by the vagus nerve, and is manifested by hypotension and bradycardia. We present 4 pediatric cardiac surgical patients, aged 1 day to 9 months, who exhibited cardiovascular collapse in their early postoperative course. In each patient, cardiovascular deterioration was marked by an insidious decrease in arterial blood pressure without an associated change in heart rate, central venous pressure, or airway pressure. Bradycardia followed the decrease in blood pressure. The Bezold-Jarisch reflex was suspected and atropine was administered, first as a bolus injection at 0.01 mg/kg, and later, as a continuous infusion at 0.01 mg.kg-1.h-1. Atropine prevented recurrent episodes of hypotension and bradycardia. We believe the Bezold-Jarisch reflex is more prevalent than previously suspected in postoperative pediatric cardiac surgical patients.
authors.affiliation: Department of Surgery, University of Colorado Health Sciences Center, Denver 80262.
authors.forename: D A
authors.initials: DA
authors.lastname: Fullerton
authors.forename: J A
authors.initials: JA
authors.lastname: St Cyr
authors.forename: D R
authors.initials: DR
authors.lastname: Clarke
authors.forename: D N
authors.initials: DN
authors.lastname: Campbell
authors.forename: W H
authors.initials: WH
authors.lastname: Toews
authors.forename: W M
authors.initials: WM
authors.lastname: See
mesh_terms: D001285:Atropine / Q000627:therapeutic use; D001919:Bradycardia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D006321:Heart / Q000294:innervation / Q000503:physiopathology; D006801:Humans; D007022:Hypotension / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012021:Reflex, Abnormal
chemical_list: D001285:Atropine