MR measurement of intracranial CSF volume in 41 elderly normal volunteers.
A noninvasive nonplanimetric MR protocol was used to measure the total intracranial CSF volume in 41 normal subjects, aged 60-84 years, who were intensively screened to eliminate CNS disease. The protocol entailed application of MR imaging data acquired with a spin-echo sequence in a single thick slice encompassing the head. The results show a strong correlation between increased intracranial CSF volume and increasing age, and a weaker correlation between increased intracranial CSF volume and increasing total intracranial volume. The possibility of employing a CSF volume measurement as a reflection of brain atrophy to help diagnose dementia is discussed.
Malko
J A
JA
Department of Radiology, Emory University School of Medicine, Atlanta, GA 30322.
Hoffman
J C
JC
Green
R C
RC
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000134:cerebrospinal fluid*; D001921:Brain / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012016:Reference Values