High-dose IgG for neutropenic patients with acquired immunodeficiency syndrome (AIDS).
Leukocytopenia and bacterial infections are common and serious complications in patients with AIDS. We report here on three patients in whom the administration of high IgG doses led to gradual (two patients) or prompt (one patient) increases in circulating leukocyte counts (from 200-600 to 2500-5900/microliters), inducing definite improvement in two patients; one patient died from Pneumocystis carinii pneumonia. Although the rise in leukocyte counts lasted for only approximately 3 weeks, high-dose IgG might be a useful therapeutic adjunct in such patients.
Salama
A
A
Department of Internal Medicine, Justus Liebig University Giessen, Federal Republic of Germany.
Lohmeyer
J
J
Seeger
W
W
Mueller-Eckhardt
C
C
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000188:drug therapy; D000740:Anemia / Q000139:chemically induced; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000627:therapeutic use; D009503:Neutropenia / Q000188:drug therapy*; D013921:Thrombocytopenia / Q000139:chemically induced; D015215:Zidovudine / Q000009:adverse effects / Q000627:therapeutic use
D007074:Immunoglobulin G; D015215:Zidovudine