Serum antibodies to GM1 and GM3-gangliosides in systemic lupus erythematosus with chronic inflammatory demyelinating polyradiculoneuropathy.
Acute symmetric demyelinating polyneuropathy of the Guillain-Barré type is known in systemic lupus erythematosus (SLE). Chronic idiopathic demyelinating polyneuropathy (CIDP) has been reported rarely with SLE. A case is reported of CIDP accompanying SLE with autoantibodies against GM1- and GM3-gangliosides. There was no historical evidence to suggest SLE, and CIDP was the first manifestation of SLE. The 38-year-old patient had elevated CSF-protein, slow nerve conduction velocities, sural nerve biopsy revealed mixed axon loss with demyelination and CIDP white matter lesions were observed in magnetic resonance imaging, the GM1- and GM3-autoantibodies may play a role in the pathogenesis of CIDP in SLE.
Sindern
E
E
Department of Neurology and clinical Neurophysiology, Medical School of Hannover, Germany.
Stark
E
E
Haas
J
J
Steck
A J
AJ
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000276:immunology; D005677:G(M1) Ganglioside / Q000276:immunology*; D005678:G(M2) Ganglioside / Q000032:analysis*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D009460:Neurologic Examination; D011129:Polyradiculoneuropathy / Q000175:diagnosis / Q000276:immunology*
D001323:Autoantibodies; D005678:G(M2) Ganglioside; D005677:G(M1) Ganglioside