title: Disinfecting activities of non-peroxide soft contact lens cold disinfection solutions.
abstract: The antimicrobial activities of three non-peroxide soft contact lens chemical disinfection systems--ReNu Multi-Purpose Solution (0.00005% polyaminopropyl biguanide), Opti-Soft Disinfecting Solution (0.001% polyquaternium-1), and Opti-Free Rinsing, Disinfecting & Storage Solution (0.001% polyquaternium-1)--were compared to Soft Mate Disinfecting Solution (0.005% chlorhexidine digluconate). Each product was separately inoculated with each of five microorganisms at approximately 10(6) microorganisms per mL. All of the solutions demonstrated excellent disinfecting activity against Pseudomonas aeruginosa and Staphylococcus epidermidis, with complete disinfection occurring within 4 hours. Only Soft Mate disinfected Serratia marcescens within 4 hours. ReNu reduced the microorganisms to 10-100 cells/mL and Opti-Soft and Opti-Free reduced the number to 10(2)-10(3) cells/mL. For the fungal species, Soft Mate showed excellent activity against Candida albicans (disinfection in 4 hours) and reduced Aspergillus fumigatus to 10(3) spores/mL in 4 hours. After 4 hours ReNu, Opti-Soft, and Opti-Free had reduced C. albicans only slightly, to 10(5) cells/mL and displayed virtually no disinfecting activity against A. fumigatus. For these newer chemical disinfection systems, diligent cleaning and rinsing of the soft contact lenses are the most important steps in the patient care regimen.
authors.affiliation: Sola/Barnes-Hind, Sunnyvale, CA 94086.
authors.forename: K L
authors.initials: KL
authors.lastname: Shih
authors.forename: M K
authors.initials: MK
authors.lastname: Raad
authors.forename: J C
authors.initials: JC
authors.lastname: Hu
authors.forename: W J
authors.initials: WJ
authors.lastname: Gresh
authors.forename: S I
authors.initials: SI
authors.lastname: Jiries
authors.forename: L J
authors.initials: LJ
authors.lastname: Caldwell
authors.forename: M V
authors.initials: MV
authors.lastname: Bergamini
mesh_terms: D001419:Bacteria / Q000187:drug effects; D002710:Chlorhexidine / Q000031:analogs & derivatives; D015169:Colony Count, Microbial; D003263:Contact Lenses, Hydrophilic; D004202:Disinfectants / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D011108:Polymers
chemical_list: D004202:Disinfectants; D011108:Polymers; C058655:polyquaternium 1; C010882:chlorhexidine gluconate; D002710:Chlorhexidine