title: The Chinese hamster cell mutant V-H4 is homologous to Fanconi anemia (complementation group A).
abstract: V-H4, a mitomycin C (MMC)-sensitive Chinese hamster cell mutant, is phenotypically very similar to Fanconi anemia (FA) cells. Genetic complementation analysis shows that V-H4 belongs to the same complementation group as FA group A cells. Proliferating hybrid cell lines obtained after fusion of V-H4 with normal or FA group B cells show an increased resistance to MMC. Absence of complementation was noted in V-H4 x FA group A hybrid cell lines. This was shown not to be due to the absence of a specific human chromosome. The V-H4 mutant represents the first rodent mutant that is genotypically similar to FA complementation group A cells.
authors.affiliation: Department of Human Genetics, Medical Faculty, Free University, Amsterdam, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Arwert
authors.forename: M A
authors.initials: MA
authors.lastname: Rooimans
authors.forename: A
authors.initials: A
authors.lastname: Westerveld
authors.forename: J W
authors.initials: JW
authors.lastname: Simons
authors.forename: M Z
authors.initials: MZ
authors.lastname: Zdzienicka
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D006224:Cricetinae; D003412:Cricetulus; D005199:Fanconi Anemia / Q000235:genetics*; D005816:Genetic Complementation Test; D005838:Genotype; D006801:Humans; D006822:Hybrid Cells / Q000187:drug effects; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009154:Mutation; D010641:Phenotype; D012689:Sequence Homology, Nucleic Acid
chemical_list: D008937:Mitomycins; D016685:Mitomycin