[Antibiotic inhalation in cystic fibrosis. A review of the literature].
Although antibiotic aerosols are widely used for the long-term treatment of chronic Pseudomonas aeruginosa infection in patients with cystic fibrosis, there are no clear therapeutic guidelines for the use of inhaled antibiotics due to the lack of large, well-controlled studies. This paper will review the current knowledge on the deposition and pharmacokinetics, the indication, clinical benefit and possible adverse reactions of inhaled antibiotics.
Steinkamp
G
G
Abteilung Kinderheilkunde I und Pädiatrische Pneumologie, Medizinischen Hochschule Hannover.
D000280:Administration, Inhalation; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002648:Child; D003550:Cystic Fibrosis / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D011552:Pseudomonas Infections / Q000097:blood / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012141:Respiratory Tract Infections / Q000097:blood / Q000188:drug therapy*
D000900:Anti-Bacterial Agents
Antibiotikainhalation bei zystischer Fibrose. Eine Literaturübersicht.