[Effects of gamma-aminobutyric acid antagonist, 4-ethyl bicyclo-phosphate, on total and synaptic evoked responses in neurons of hippocampal slices].
Influence of 4-E-BPE on the amplitude of population spices (PS) evoked in CA1 area by Shaffer collateral stimulation in hippocampal slices were analysed. Bath application of 4-E-BPE (10(-6)-10(-5) M) led to a pronounced increase in the amplitude of the PS, the appearance of secondary PS and then introduction of GABA led to restoring original state. The 4-E-BPE was more potent than picrotoxin. These findings suggest that 4-E-BPE suppress inhibitory synaptic transmission in the CA1 region of hippocampus.
Pervukhin
G Ia
GIa
Sharonova
I N
IN
Prokof'ev
S E
SE
Fedorov
N B
NB
Sokolov
V B
VB
Martynov
I V
IV
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D005071:Evoked Potentials; D018756:GABA Antagonists; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010852:Picrotoxin / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D018756:GABA Antagonists; D009943:Organophosphorus Compounds; D010852:Picrotoxin; C065518:4-ethyl-1-phospha-2,6,7 trioxabicyclo(2.2.2)octane-1-oxide
Vliianie antagonista gamma-aminomaslianoĭ kisloty 4-étilbitsiklofosfata na summarnye i sinapticheskie vyzvannye otvety neĭronov srezakh gippokampa.