[The toxicity of surface-active substances for emulsifying perfluorocarbon compounds as components of blood substitute preparations].
Perfluorocarbons are insoluble in water. For being used as oxygen carriers in blood substitutes they therefore have to be emulsified. Using surfactants in the living organism a compromise on the emulsifying effect and toxicity is to be made, since good emulsifiers do also affect biological membranes. The influence of molecule parameters of surfactants on toxicity was studied in this paper.
Draffehn
J
J
Militärmedizinische Akademie, Bad Saarow.
Reichelt
H
H
D000818:Animals; D001802:Blood Substitutes / Q000737:chemistry / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects; D005079:Excipients / Q000737:chemistry / Q000633:toxicity*; D005466:Fluorocarbons / Q000737:chemistry*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D051379:Mice; D008808:Mice, Inbred CBA; D013501:Surface-Active Agents / Q000633:toxicity*
D001802:Blood Substitutes; D005079:Excipients; D005466:Fluorocarbons; D013501:Surface-Active Agents
Untersuchungen zur Toxizität oberflächenaktiver Substanzen zur Emulgierung von Perfluorcarbonverbindungen als Bestandteil von Blutersatzmitteln.