title: Treatment of superior vena cava thrombosis with recombinant tissue type plasminogen activator.
abstract: Thrombotic occlusion of the superior vena cava is an uncommon but serious complication of chronic indwelling venous catheters. Several reports have shown thrombolytic therapy with intravenous streptokinase or urokinase to be effective in the treatment of this condition. We report a case of superior vena cava thrombosis in a 53-year-old woman receiving chemotherapy for breast carcinoma through a subcutaneously implanted venous access catheter who was successfully treated with peripheral infusion of recombinant tissue type plasminogen activator (rtPA).
authors.affiliation: Division of Hematology, Medical Oncology, Monmouth Medical Center, Long Branch, NJ.
authors.forename: S
authors.initials: S
authors.lastname: Greenberg
authors.forename: R
authors.initials: R
authors.lastname: Kosinski
authors.forename: J
authors.initials: J
authors.lastname: Daniels
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000188:drug therapy; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002408:Catheters, Indwelling; D005260:Female; D006801:Humans; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D013479:Superior Vena Cava Syndrome / Q000188:drug therapy* / Q000209:etiology; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator