Drosophila melanogaster diphenol oxidase A2: gene structure and homology with the mouse mast-cell tum- transplantation antigen, P91A.
The Drosophila melanogaster diphenol oxidase (DOX) A2-encoding gene (Dox-A2) is involved in catecholamine metabolism, melanin formation and sclerotization of the cuticle. Insect phenol oxidases (POX) are well studied biochemically, but not genetically and molecularly. The Dox-A2 (2-53.9) gene is the first insect POX-encoding gene to be cloned and sequenced. It encodes a protein product unique among currently known POX. The deduced protein, however, exhibits extensive similarity (58-81%) to the mouse mast cell tum- antigen, P91A [Lurquin et al., Cell 58 (1989) 293-303] and may identify the normal mouse protein as a DOX.
Pentz
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Department of Biology, University of Virginia, Charlottesville 22901.
Wright
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004156:Catechol Oxidase / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D006649:Histocompatibility Antigens / Q000235:genetics*; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D008969:Molecular Sequence Data; D011061:Poly A / Q000235:genetics; D016415:Sequence Alignment; D016385:TATA Box / Q000235:genetics
D006649:Histocompatibility Antigens; C070850:transplantation antigen P91A, mouse; D011061:Poly A; D004156:Catechol Oxidase