title: Dosage compensation of the Drosophila pseudoobscura Hsp82 gene and the Drosophila melanogaster Adh gene at ectopic sites in D. melanogaster.
abstract: Measurements were made of the amounts of larval RNA transcribed from the autosomal Adh gene of Drosophila melanogaster and the X chromosomal Hsp82 gene of Drosophila pseudoobscura carried on the same P-element transposon inserted at various sites in the D. melanogaster genome. Both genes were fully compensated at sites in euchromatic regions of the X chromosome but neither was compensated at a site in the centric beta-heterochromatin of the X chromosome. No compensation of the D. pseudoobscura Hsp82 gene was found at any of 10 autosomal insertion sites tested. The compensation behavior of the transposed genes was, therefore, not determined by closely linked sequences but instead was determined in each case by their new chromosomal environment.
authors.affiliation: Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
authors.forename: H
authors.initials: H
authors.lastname: Sass
authors.forename: M
authors.initials: M
authors.lastname: Meselson
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000818:Animals; D004330:Drosophila / Q000235:genetics*; D004331:Drosophila melanogaster / Q000201:enzymology / Q000235:genetics*; D005091:Exons; D005260:Female; D015870:Gene Expression; D006360:Heat-Shock Proteins / Q000235:genetics*; D007438:Introns; D008297:Male; D011544:Pseudogenes; D014158:Transcription, Genetic; D014170:Transformation, Genetic; D014960:X Chromosome
chemical_list: D006360:Heat-Shock Proteins; D000426:Alcohol Dehydrogenase