title: Magnesium sulphate as a new desensitizing agent.
abstract: Various desensitizing agents have been used in clinics to solve the problem of dentinal hypersensitivity (DH), but none of them has been shown to be consistently effective. We here introduce a new type of desensitizing agent, i.e. 4% magnesium sulphate with iontophoresis at 2mA for 3 min. These optimal conditions were determined by animal experiments, while only a minor effect on dentinal issues was observed within 4 weeks after the treatment. When this desensitizing agent was used to treat DH, the cure rate of 62.4% remained steady within the 25-week observation period, while some effect was achieved in all the subjects who participated in the study.
authors.affiliation: Faculty of Stomatology, Guanxi Medical College, Nanning, People's Republic of China.
authors.forename: G H
authors.initials: GH
authors.lastname: Liu
authors.forename: M
authors.initials: M
authors.lastname: Morimoto
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D003804:Dentin / Q000187:drug effects / Q000648:ultrastructure; D003807:Dentin Sensitivity / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D006801:Humans; D007478:Iontophoresis; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D009566:Nitrates / Q000627:therapeutic use; D017680:Potassium Compounds
chemical_list: D009566:Nitrates; D017680:Potassium Compounds; D008278:Magnesium Sulfate; C023844:potassium nitrate