Continuous intestinal dialysis for uraemia by intermittent oral intake of non-absorbable solutions. An experimental study.
A new approach to intestinal dialysis was investigated in a normal person and in a patient with chronic uraemia and a renal creatinine clearance of 10 ml/min. Both subjects drank 1-1.5 l non-absorbable solutions of polyethylene glycol or mannitol every fourth hour. The solutions stayed in the intestines for about four hours in the normal person and for 1.5 to 3 hours in the patient. The patient's intestinal clearances were 6-10.4 ml/min for creatinine, 4 ml/min for uric acid and 10.7-15.4 ml/min for phosphate, which compares favourably to those from 12 hours weekly haemodialysis. Continuous intestinal dialysis was well tolerated and the results indicate that this might be a useful way of treating uraemia if conventional methods are unavailable.
Miskowiak
J
J
Department of Nephrology, Herlev Hospital, University of Copenhagen, Denmark.
D000284:Administration, Oral; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008353:Mannitol / Q000008:administration & dosage*; D008875:Middle Aged; D010710:Phosphates / Q000378:metabolism; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D006435:Renal Dialysis / Q000379:methods*; D014508:Urea / Q000378:metabolism*; D014511:Uremia / Q000503:physiopathology / Q000628:therapy*; D014527:Uric Acid / Q000378:metabolism
D010710:Phosphates; D014527:Uric Acid; D008353:Mannitol; D011092:Polyethylene Glycols; D014508:Urea; D003404:Creatinine