Antibiotic concentrations in liquor compared to the minimal inhibitory concentrations of isolates in paediatric bacterial meningitis. The Finnish Study Group.
The susceptibilities of 171 bacteria which caused meningitis in 200 children were tested for their susceptibility as minimal inhibitory concentrations (MICs) for the antibiotics used in therapy. These antibiotics were chloramphenicol, ampicillin, cefotaxime and ceftriaxone. The MICs were compared to the minimal concentrations of the drugs seen in the cerebrospinal fluid (CSF) samples. The minimal bacteriostatic capacity (lowest concentration in CSF/MIC) of both cephalosporins was superior to that of chloramphenicol and ampicillin. The correlation of the finding with the speed of liquor sterilization in the treatment groups is discussed.
Ellmén
J K
JK
Department of Bacteriology and Immunology, University of Helsinki, Finland.
Renkonen
O V
OV
Anttila
M A
MA
Peltola
H O
HO
D000293:Adolescent; D000667:Ampicillin / Q000134:cerebrospinal fluid / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000134:cerebrospinal fluid* / Q000494:pharmacology / Q000627:therapeutic use; D002439:Cefotaxime / Q000134:cerebrospinal fluid / Q000494:pharmacology; D002443:Ceftriaxone / Q000134:cerebrospinal fluid / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000134:cerebrospinal fluid / Q000494:pharmacology; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007223:Infant; D008581:Meningitis / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D009345:Neisseria meningitidis / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D002443:Ceftriaxone; D000667:Ampicillin; D002439:Cefotaxime