[Dose calibration of aztreonam in pediatric patients by means of pharmacokinetic analysis].
One of the current pharmacological problems with antibiotics is possible overdose among children of 7 years of age and older, when their dose was calculated on a per kg basis. In order to evaluate the difficulties, a pharmacokinetic analysis of aztreonam (AZT), which is a monocyclic beta-lactam antimicrobial agent, was undertaken in 2 groups consisting of 5 children of ages 1-6 and 5 older children of 7-15. Data from the younger children were fitted both to one- and two-compartment models while those from the older age group perfectly were fitted to a two-compartment model. Using these fitted curve, a simulation dose study was carried out in order to see if we can find a clue for a better dose calibration for the older group of children. The results suggested that the dose of AZT in per kg basis for the older children can be reduced to 60% levels of the younger, that is, 60 mg/kg for the older in contrast to 100 mg/kg for the younger.
Kawasaki
H
H
Department of Pediatrics, Tohoku Rosai Hospital.
D000367:Age Factors; D001398:Aztreonam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001827:Body Height; D001835:Body Weight; D002138:Calibration; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008954:Models, Biological; D013810:Therapeutic Equivalency
D001398:Aztreonam