title: An assessment of cerebral blood flow and metabolism after fleroxacin therapy.
abstract: Cerebral blood flow (CBF), glucose (FDG), and oxygen metabolism (OM) were evaluated by positron emission tomography (PET) in 18 healthy volunteers who were randomized to a 72-hour course of either 600 mg/d of fleroxacin or placebo. Such studies attempted to assess potentially serious, yet unexplained, central nervous system adverse effects of the fluorinated quinolone class. Baseline and postplacebo values for CBF (mL/min/100 g) and FDG (mg/min/100 g) were: 53 +/- 6 and 5.7 +/- 1.8; and 49.6 +/- 4.4, and 5.2 +/- 1.2, respectively. Identical values for fleroxacin were: 53.9 +/- 4.8 and 6.3 +/- 1.1; and 54.4 +/- 2.2 and 6.8 +/- 1.5, respectively. The differences between fleroxacin and placebo were not significant. There was also no effect seen in OM between placebo and the active drug. The authors conclude that short-term administration of fleroxacin does not alter CBF, FDG, or OM in healthy volunteers.
authors.affiliation: Division of Cardiology, University Hospitals of Cleveland, OH 44106.
authors.forename: S F
authors.initials: SF
authors.lastname: Gardner
authors.forename: J A
authors.initials: JA
authors.lastname: Green
authors.forename: E M
authors.initials: EM
authors.lastname: Bednarczyk
authors.forename: A D
authors.initials: AD
authors.lastname: Nelson
authors.forename: G
authors.initials: G
authors.lastname: Leisure
authors.forename: F
authors.initials: F
authors.lastname: Miraldi
mesh_terms: D000328:Adult; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002540:Cerebral Cortex / Q000098:blood supply* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005069:Evaluation Studies as Topic; D016576:Fleroxacin; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D010100:Oxygen / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D005947:Glucose; D016576:Fleroxacin; D010100:Oxygen