[Ovarian steroid synthesis in tissue culture after administration of hormones and epidermal growth factor].
The features of steroidogenesis of immature mouse ovaries in culture under the influence of follicle-stimulating hormones (FSH), human chorionic gonadotropin (hCG), epidermal growth factor (EGF) and insulin have been investigated during the period of reinitiation of meiosis in the oocytes. Secretion of progesterone is stimulated after addition of FSH, hCG and of insulin and EGF combination to the medium. EGF increases FSH-stimulated progesterone secretion and inhibits estradiol secretion. The ratios progesterone/estradiol and testosterone/estradiol increase, when EGF is added to the culture medium. It is analogous to the action of hCG. It is suggested that EGF may be an intrafollicular EGF regulator of luteinizing hormone action on the sex and somatic cells of the mammalian ovaries.
Vorob'eva
O A
OA
Svechnikova
F A
FA
Nikitin
A I
AI
Potin
V V
VV
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004347:Drug Interactions; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004958:Estradiol / Q000096:biosynthesis*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D066298:In Vitro Techniques; D051379:Mice; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D011374:Progesterone / Q000096:biosynthesis*; D013739:Testosterone / Q000096:biosynthesis*
D006063:Chorionic Gonadotropin; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D004815:Epidermal Growth Factor; D005640:Follicle Stimulating Hormone
Steroidogenez iaichnikov v kul'ture pri deĭstvii gormonov i epidermal'nogo faktora rosta.