title: Cytokines in T-cell development.
abstract: The thymus provides a unique environment for the development of T cells, supporting both precursor cell proliferation and differentiation. The control of these processes is unknown but they may be mediated by cytokines, or other soluble factors, or by interactions with specific elements of the thymic stroma. Here, Simon Carding, Adrian Hayday and Kim Bottomly describe cellular, immunochemical and molecular studies of the production and action of cytokines within the human and mouse thymus and demonstrate their essential role in T-cell development.
authors.affiliation: Dept of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia 19104.
authors.forename: S R
authors.initials: SR
authors.lastname: Carding
authors.forename: A C
authors.initials: AC
authors.lastname: Hayday
authors.forename: K
authors.initials: K
authors.lastname: Bottomly
mesh_terms: D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D009924:Organ Culture Techniques; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
chemical_list: D016207:Cytokines