title: Role of aminophylline in atropine resistant atrioventricular block.
abstract: Atrioventricular (AV) block may be induced by ischaemia as a result of production of adenosine, a metabolite that accumulates during hypoxia and ischaemia. Adenosine antagonism has been shown to reverse experimental AV node block in dogs. Recently, theophylline has been shown to be highly effective in diminishing the frequency and severity of bradycardia in newborn infants with apnoea-bradycardia spells. We report here a case of acute inferior wall myocardial infarction who developed atropine resistant AV block which was reversed by aminophylline, a competitive, antagonist of adenosine.
authors.affiliation: Department of Medicine, SDM Hospital, Rajasthan.
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: A
authors.initials: A
authors.lastname: Jain
authors.forename: S C
authors.initials: SC
authors.lastname: Kala
mesh_terms: D000628:Aminophylline / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use*; D004562:Electrocardiography / Q000187:drug effects*; D006327:Heart Block / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications
chemical_list: D000628:Aminophylline; D001285:Atropine