title: Hepatic hemangioblastoma. An unusual presentation in a patient with von Hippel-Lindau disease.
abstract: We report a case of multiple capillary hemangioblastomas of the liver occurring in a patient with von Hippel-Lindau disease and a history of previous cerebellar and spinal hemangioblastomas. Although rare examples of this tumor have previously been recorded in the pancreas, kidney, and urinary bladder, this appears to be the first recorded case with hepatic involvement. The histology and immunohistochemical appearance of this neoplasm are identical with those of the cerebellar tumor. We believe it represents a separate primary neoplasm rather than metastatic disease.
authors.affiliation: Department of Pathology, University of British Columbia and Vancouver General Hospital, Canada.
authors.forename: A M
authors.initials: AM
authors.lastname: Rojiani
authors.forename: D A
authors.initials: DA
authors.lastname: Owen
authors.forename: K
authors.initials: K
authors.lastname: Berry
authors.forename: B
authors.initials: B
authors.lastname: Woodhurst
authors.forename: F H
authors.initials: FH
authors.lastname: Anderson
authors.forename: C H
authors.initials: CH
authors.lastname: Scudamore
authors.forename: S
authors.initials: S
authors.lastname: Erb
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006394:Hemangiosarcoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D037102:Lectins / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D037121:Plant Lectins; D011086:Polycythemia / Q000209:etiology / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism; D013120:Spinal Cord Neoplasms / Q000150:complications / Q000473:pathology; D006623:von Hippel-Lindau Disease / Q000150:complications* / Q000378:metabolism / Q000473:pathology
chemical_list: D005904:Glial Fibrillary Acidic Protein; D037102:Lectins; D037121:Plant Lectins; D009418:S100 Proteins; C036850:Ulex europaeus lectins; D005169:Factor VIII; D010751:Phosphopyruvate Hydratase