[Auditory event-related potentials in Parkinson's disease].
The results of event-related potential (ERP) components were studied in 25 cases of Parkinson's disease. This study included 33 normal volunteers (14 females and 19 males). With no prior history of neurologic or psychiatric illness. They were all over 50 years of age in "Auditory oddball" event-related potential paradigm. All of the Patients (20 males and 5 females) were 45-80 year's old. The latencies of the patients on N2P3aP3b wave which reflected cognitive process (activity) were significantly prolonged (P less than 0.001, P less than 0.001, P less than 0.02). The amplitude of P3a, P3b wave were decreased (P less than 0.001). This cognitive function were markedly different from normal. It's valuable in the diagnosis and follow up of Parkinson's disease. The origin of waves of ERP components and clinical application were also discussed in this paper.
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Z Y
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People Hospital, Beijing Medical University.
D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000502:physiology; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*