Glomerulopressin production by isolated rat liver after amino acid infusion.
The infusion of certain amino acids, such as serine, alanine, and proline (SAP), has been shown to increase the glomerular filtration rate, whereas branched chain amino acids (BCAA) leucine, isoleucine, and valine fail to modify the glomerular filtration rate. It has been suggested that this effect of amino acids on the glomerular filtration rate is mediated by the action of the hormone glomerulopressin. The purpose of this work was to study the action of SAP and BCAA on glomerulopressin production. Livers isolated from rats were perfused with (i) Krebs-Ringer-Bicarbonate, (ii) SAP, or (iii) BCAA. Results indicate that glomerulopressin production is stimulated by SAP, but inhibited by BCAA.
Silberstein
C
C
Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina.
Brandariz
S
S
Arteman
P
P
Aguirre
J
J
Uranga
J
J
del Castillo
E
E
D000409:Alanine / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology*; D000597:Amino Acids, Branched-Chain / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D015232:Dinoprostone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005965:Glucuronates / Q000378:metabolism*; D007262:Infusions, Intravenous; D008099:Liver / Q000378:metabolism*; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011392:Proline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012694:Serine / Q000494:pharmacology
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D005965:Glucuronates; C014007:glomerulopressin; D012694:Serine; D011392:Proline; D015232:Dinoprostone; D000409:Alanine