Occurrence of autoimmune antibodies to liver microsomal proteins in association with fulminant hepatitis in the LEC strain of rats.
The Long Evans Cinnamon (LEC) rat, which has been established as a strain showing hereditary hepatitis and hepatic carcinoma, was found to possess autoimmune antibodies to liver microsomal proteins, particularly to a protein with the molecular weight of 56kD. The antibodies also recognized a protein(s) in liver microsomes from Long Evans Agouti and Sprague-Dawley rats. About 42 and 15 percent of respective female and male LEC rats died within a week after acute hepatitis; sera from all of the animals contained the antibodies. About 43 and 0 percent of the surviving female and male LEC rats possessed the antibodies, respectively. These results suggest that the autoantibodies occur in association with acute lethal hepatitis in the LEC rats.
Nagayama
S
S
Division of Analytical Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Kitamura
R
R
Yokoi
T
T
Kawaguchi
Y
Y
Kasai
N
N
Takeichi
N
N
Kobayashi
H
H
Kamataki
T
T
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000235:genetics / Q000276:immunology* / Q000401:mortality; D015151:Immunoblotting; D008297:Male; D008565:Membrane Proteins / Q000276:immunology; D008862:Microsomes, Liver / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D013347:Subcellular Fractions
D001323:Autoantibodies; D008565:Membrane Proteins