Novel effects of MPTP: MAO-B unrelated opioidergic activity in mice.
The presence of opioidergic activity after i.p. injection of N-methyl-4-phenyl tetrahydropyridine (MPTP) has been investigated in albino mice by studying analgesia and the Straub reaction. MPTP (6.25-25 mg kg-1) produced a dose-related analgesic response and Straub reaction. These effects of MPTP were effectively antagonized by prior naloxone treatment but remained unaffected after the MAO-B inhibitor deprenyl. MPTP thus possesses significant opioidergic activity and this, unlike its neurotoxic actions, does not appear to be dependent on oxidative conversion to MPP+ (1-methyl-4-phenyl pyridinium).
Nath
C
C
Department of Pharmacology, K.G's. Medical College, Lucknow, India.
Gurtu
S
S
Gupta
M B
MB
Gupta
G P
GP
Srimal
R C
RC
Dhawan
B N
BN
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000698:Analgesia; D000818:Animals; D005260:Female; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008995:Monoamine Oxidase / Q000378:metabolism*; D009270:Naloxone / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*; D011187:Posture; D012016:Reference Values; D012642:Selegiline / Q000494:pharmacology*
D007527:Isoenzymes; D009294:Narcotics; D012642:Selegiline; D009270:Naloxone; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D008995:Monoamine Oxidase