Treatment with antioxidants does not prevent loss of dopamine in the striatum of MPTP-treated common marmosets: preliminary observations.
Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to common marmosets causes a profound loss of dopamine and serotonin in the striatum. Additional daily systemic treatment of monkeys with the antioxidants ascorbic acid (100 mg/kg) and alpha-tocopherol (2,350 mg/kg) prior to, during and following administration of MPTP does not prevent the loss of dopamine and serotonin in the striatum, suggesting that these antioxidants are unable to protect dopaminergic neurones against neurotoxicity of MPTP.
Mihatsch
W
W
Department of Neurology, University of Bochum, Federal Republic of Germany.
Russ
H
H
Gerlach
M
M
Riederer
P
P
Przuntek
H
H
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D002143:Callitrichinae; D003342:Corpus Striatum / Q000737:chemistry* / Q000187:drug effects; D004298:Dopamine / Q000032:analysis*; D005260:Female; D020267:MPTP Poisoning; D008297:Male; D012701:Serotonin / Q000032:analysis; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D012701:Serotonin; D001205:Ascorbic Acid; D004298:Dopamine