Excretion of phenoxymethylpenicillin in the vaginal fluid of hysterectomized women.
The excretion of phenoxymethylpenicillin in vaginal fluid was determined in 19 hysterectomized women, 8 totally and 11 subtotally operated. Phenoxymethylpenicillin was found in the vaginal fluid in high concentrations in both groups of women and it was concluded that the substance penetrates the vaginal wall. Concentrations were significantly higher in the most distal part of the vagina. The possible mechanisms for this phenomenon are discussed.
Sjöberg
I
I
Department of Obstetrics and Gynecology, Umeå University Hospital, Sweden.
Håkansson
S
S
D000284:Administration, Oral; D000328:Adult; D001826:Body Fluids / Q000737:chemistry*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D010404:Penicillin V / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014621:Vagina / Q000378:metabolism*
D010404:Penicillin V