Effect of estrogen and progesterone on the hepatic cholesterol 7-alpha-hydroxylase activity in ovariectomized baboons.
Cholesterol 7 alpha-hydroxylase activity was measured in livers from ovariectomized baboons fed a high cholesterol high saturated fat diet and maintained in four groups: untreated controls, estrogen (100 micrograms/g per week), progesterone (3 mg/kg per day) and estrogen + progesterone. Estrogen treatment alone increased hepatic 7 alpha-hydroxylase activity by 2.7-fold, whereas progesterone treatment alone did not influence hepatic 7 alpha-hydroxylase activity. The increase in 7 alpha-hydroxylase activity in estrogen + progesterone group was similar to that in the estrogen group.
Kushwaha
R S
RS
Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX.
Born
K M
KM
D000818:Animals; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000097:blood; D004036:Diet, Atherogenic; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010052:Ovariectomy; D010215:Papio; D011374:Progesterone / Q000494:pharmacology*
D008078:Cholesterol, LDL; D004967:Estrogens; D011374:Progesterone; D002790:Cholesterol 7-alpha-Hydroxylase