[Combination treatment of acute non-lymphocytic leukemia with HOAP and AA--preliminary report of 14 cases].
Fourteen patients with acute non-lymphocytic leukemia (ANLL) were alternately treated with HOAP (harritonine, oncovin, Ara-C and prednisone) and AA (adriamycin and Ara-C). The complete response rate was 64.3% (9/14). Four in 5 previously untreated patients and 5 in 9 patients with relapse achieved complete response. The side effects were weakness, gastrointestinal disturbance, bone marrow suppression and pancytopenia, which lasted for 2-3 weeks after discontinuation of treatment. Sinus tachycardia was noted in 3 cases and inverted T wave in 2. The authors consider that this may be a treatment of choice in ANLL because of its high response rate, shorter attainment to complete remission and mild side effects. But the long term results still need to be studied.
Zhang
G Z
GZ
Zhongshan Hospital, Shanghai Medical College.
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006248:Harringtonines / Q000008:administration & dosage; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D006248:Harringtonines; D003561:Cytarabine; D014750:Vincristine; D004317:Doxorubicin; D011241:Prednisone