title: Soluble interleukin-2 receptor and soluble CD8 antigen levels in serum from patients with non-resectable lung cancer.
abstract: In a preliminary longitudinal study two women with histologically verified adenocarcinoma of the lung, without simultaneous infectious or inflammatory conditions, were seen every 2 weeks until death. In one of the patients serum soluble interleukin-2 receptor (sIL-2R) levels rose progressively while the levels for the other patient increased during the second half of the observation period. Serum soluble CD8 antigen (sCD8 Ag) showed a pattern dissimilar to the one for sIL-2R. In a retrospective cross-sectional study circulating levels of sIL-2R and sCD8 Ag were measured before explorative thoracotomy in a total of 65 patients with histologically proven non-resectable carcinoma of the lung. The sIL-2R levels were significantly increased independently of histological subclassification while sCD8 Ag was increased only in patients with small-cell lung cancer. There was no correlation between pre-operative values and length of survival.
authors.affiliation: Department of Medicine TTA, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Vibe-Petersen
authors.forename: N
authors.initials: N
authors.lastname: Tvede
authors.forename: M
authors.initials: M
authors.lastname: Diamant
authors.forename: A A
authors.initials: AA
authors.lastname: Kjerulff
authors.forename: H R
authors.initials: HR
authors.lastname: Sørensen
authors.forename: V
authors.initials: V
authors.lastname: Andersen
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D016827:CD8 Antigens; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000032:analysis; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000276:immunology*; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D016207:Cytokines; D015375:Receptors, Interleukin-2