Non-lymphoid blast crisis of CML with rearrangement of immunoglobulin and T-cell receptor delta genes.
We report a patient with chronic myeloid leukaemia (Philadelphia-positive with M-BCR rearrangement) in transformation whose blast cells had myelomonocytic morphology, absent terminal deoxynucleotidyl transferase expression and non-lymphoid cell surface markers (CD10-, CD19-, CD33+, CD14+, CD11+). Leukaemia cell DNA showed rearrangement of both immunoglobulin heavy chain and T-cell receptor delta genes. Such rearrangements may be a feature of a small proportion of patients with non-lymphoid transformation of CML as they are in a minority of cases of de novo acute non-lymphoblastic leukaemia.
Bashey
A
A
Department of Haematology, Royal Postgraduate Medical School, London, U.K.
Vulliamy
T
T
Cai
B S
BS
Schwarer
A P
AP
Goldman
J M
JM
D000208:Acute Disease; D000328:Adult; D001752:Blast Crisis; D015321:Gene Rearrangement; D015329:Gene Rearrangement, T-Lymphocyte; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007951:Leukemia, Myeloid / Q000235:genetics / Q000473:pathology*; D008297:Male
D007143:Immunoglobulin Heavy Chains