title: Serum hyaluronate and type III procollagen aminoterminal propeptide concentration in chronic liver disease. Relationship to cirrhosis and disease activity.
abstract: To analyse the relationship between the presence of liver cirrhosis and hepatic inflammation and the serum concentrations of the aminoterminal propeptide of procollagen type III (P-III-NP) and of hyaluronic acid (HA) in chronic liver disease, we measured P-III-NP and HA concentrations in paired serum samples from 133 patients with various chronic liver diseases, from 22 patients with acute hepatitis and from 50 healthy age-matched controls. In 24 (of the 133) patients with autoimmune chronic liver disease, follow-up determination was performed during therapeutic treatment with immunosuppressive drugs. Compared with controls P-III-NP concentrations (medians) were significantly elevated in 65% of patients with chronic active hepatitis (P = 0.00097) and in 79% of patients with active liver cirrhosis (P = 0.0126) but not in patients with chronic persistent hepatitis (P = 0.06). Serum concentrations (medians) of HA were increased (P = 0.0058) in 32% of patients with chronic active hepatitis and in 91% of patients with active cirrhosis (P less than 6 x 10(-7)). The difference of HA serum concentrations but not that of P-III-NP serum concentrations in patients with chronic active hepatitis and in patients with active cirrhosis was statistically significant. HA and P-III-NP serum concentrations were significantly elevated in 22 patients with acute hepatitis.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: I Department of Internal Medicine, University of Mainz, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Ramadori
authors.forename: G
authors.initials: G
authors.lastname: Zöhrens
authors.forename: M
authors.initials: M
authors.lastname: Manns
authors.forename: H
authors.initials: H
authors.lastname: Rieder
authors.forename: H P
authors.initials: HP
authors.lastname: Dienes
authors.forename: G
authors.initials: G
authors.lastname: Hess
authors.forename: K H
authors.initials: KH
authors.lastname: Meyer
authors.forename: Z
authors.initials: Z
authors.lastname: Büschenfelde
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000097:blood; D015415:Biomarkers; D003937:Diagnosis, Differential; D005260:Female; D006505:Hepatitis / Q000097:blood; D006521:Hepatitis, Chronic / Q000097:blood / Q000175:diagnosis; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood* / Q000175:diagnosis; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D006820:Hyaluronic Acid