Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family.
The two alternative carboxyl-termini of Shaker K+ channels strongly influence the rates of inactivation and of recovery from channel inactivation. We show that this distinct inactivation behaviour is due to an alanine/valine amino acid replacement within the Shaker carboxyl-terminus at a site that occurs within the proposed membrane spanning segment S6.
Wittka
R
R
Ruhr-Universität Bochum, Lehrstuhl für Biochemie, Germany.
Stocker
M
M
Boheim
G
G
Pongs
O
O
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002462:Cell Membrane / Q000378:metabolism; D004247:DNA; D004252:DNA Mutational Analysis; D004331:Drosophila melanogaster; D004594:Electrophysiology; D007700:Kinetics; D008969:Molecular Sequence Data; D015221:Potassium Channels / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment
D015221:Potassium Channels; D004247:DNA