title: Monoterpenic fragment analogues of aplasmomycin as potential antimalarial.
abstract: Seven analogues of monoterpenic fragment of aplasmomycin were synthesized as targeted antimalarial agents. The potency of the compound 6 was comparable with the sesquiterpene lactone artemisinin and the antibiotic aplasmomycin in vivo against Plasmodium berghei yoelli.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Powai, Bombay.
authors.forename: N
authors.initials: N
authors.lastname: Balu
authors.forename: J V
authors.initials: JV
authors.lastname: Thomas
authors.forename: S V
authors.initials: SV
authors.lastname: Bhat
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000962:Antimalarials; D007476:Ionophores; D008297:Male; D051379:Mice; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D010962:Plasmodium berghei / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D007476:Ionophores; D010455:Peptides; D013729:Terpenes; C013401:aplasmomycin