title: [Cellular interstitial pneumonia and follicular bronchiolitis diagnosed by open lung biopsy in a patient with rheumatoid arthritis].
abstract: A 54-year-old woman under treatment for rheumatoid arthritis was admitted because of aggravation of dyspnea on effort and restrictive pulmonary dysfunction. Although chest X-ray revealed no marked change, the symptoms progressively worsened, necessitating open lung biopsy for diagnosis and treatment. Based on the histopathological findings of the biopsied tissue, the patient was diagnosed as having active rheumatoid lung complicated with cellular interstitial pneumonia and follicular bronchiolitis. The patient responded well to adrenocorticosteroid and immunosuppressor therapy, and is now being followed up as an outpatient. Rheumatoid arthritis can be complicated by diverse lung diseases. Among them one important disease is interstitial pneumonia, which serves as a prognostic factor. When cellular interstitial pneumonia is treated with adrenocorticosteroid therapy, it responds well and its prognosis is good. Therefore, its early detection and appropriate adrenocortical therapy are essential. Patients with rheumatoid arthritis presenting with dyspnea on effort and pulmonary dysfunction should be examined for cellular interstitial pneumonia, follicular bronchiolitis and other lung diseases, even when no marked change is visible on chest X-ray films.
authors.affiliation: Department of Respiratory Medicine, Tenri Hospital, Nara Pref., Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nambu
authors.forename: T
authors.initials: T
authors.lastname: Iwata
authors.forename: K
authors.initials: K
authors.lastname: Oida
authors.forename: Y
authors.initials: Y
authors.lastname: Kohri
authors.forename: Y
authors.initials: Y
authors.lastname: Taguchi
authors.forename: K
authors.initials: K
authors.lastname: Tomii
authors.forename: M
authors.initials: M
authors.lastname: Mino
authors.forename: Y
authors.initials: Y
authors.lastname: Yunoki
authors.forename: K
authors.initials: K
authors.lastname: Ichijima
authors.forename: Y
authors.initials: Y
authors.lastname: Kobashi
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000473:pathology; D001706:Biopsy; D001988:Bronchiolitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D011379:Prognosis; D011658:Pulmonary Fibrosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
chemical_list: D003520:Cyclophosphamide; D011239:Prednisolone