Thiazocins, new aldose reductase inhibitors from Actinosynnema sp. 1. Fermentation, isolation and characterization.
New antibiotics designated as thiazocins A and B were isolated from the culture broth of Actinosynnema sp. C-304. Thiazocins A and B exhibited inhibitory activities against an aldose reductase from human placenta.
Ozasa
T
T
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Yoneda
T
T
Hirasawa
M
M
Suzuki
K
K
Tanaka
K
K
Kadota
S
S
Iwanami
M
M
D000192:Actinomycetales / Q000378:metabolism; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002845:Chromatography; D005260:Female; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010920:Placenta / Q000201:enzymology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D000449:Aldehyde Reductase