Glycosaminoglycans in the synovial fluids of patients with juvenile rheumatoid arthritis.
A simple method was used to isolate hyaluronic acid (HA) and sulfated glycosaminoglycans from synovial fluids obtained from children with juvenile rheumatoid arthritis (JRA) and from normal age-matched controls. The bulk of the glycosaminoglycans present in both normal and pathologic synovial fluids consisted of hyaluronic acid and chondroitin 6-sulfate. The diseased synovial fluids showed a sharp decrease in the concentration of glycosaminoglycans when compared with normal controls. These findings are similar to those reported for the synovial fluid of adult patients with rheumatoid arthritis.
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PF
Department of Rheumatology, University of São Paulo, School of Medicine, Brazil.
Heise
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Toledo
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OM
D001171:Arthritis, Juvenile / Q000378:metabolism*; D005591:Chemical Fractionation; D002809:Chondroitin Sulfates / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism; D009994:Osmolar Concentration; D012016:Reference Values; D013582:Synovial Fluid / Q000378:metabolism*
D006025:Glycosaminoglycans; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates