Tamoxifen-stimulated growth of human endometrial carcinoma.
An estrogen receptor and progesterone receptor positive endometrial carcinoma (EnCa101) will grow in response to either estradiol or tamoxifen when transplanted into athymic mice. We have tested several antiestrogens with different properties to determine their ability to support endometrial tumor growth. Trioxifene, enclomiphene and nafoxidine are all as active as tamoxifen whereas the antiestrogen keoxifene, that has reduced estrogen-like properties, will partially inhibit tamoxifen-stimulated growth. Furthermore, the pure antiestrogen ICI 164,384 will block tamoxifen-stimulated growth without having any effect itself on tumor growth rate. Overall, the ability of antiestrogens to stimulate the growth of human endometrial carcinoma EnCa101 appears to be related to their intrinsic estrogenic activity.
Jordan
V C
VC
Department of Human Oncology, University of Wisconsin, Madison 53792.
Gottardis
M M
MM
Satyaswaroop
P G
PG
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000473:pathology; D002996:Clomiphene / Q000031:analogs & derivatives / Q000494:pharmacology; D064695:Enclomiphene; D004717:Endometrium / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000494:pharmacology; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009256:Nafoxidine / Q000494:pharmacology; D009368:Neoplasm Transplantation; D010880:Piperidines / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D011759:Pyrrolidines / Q000494:pharmacology; D020849:Raloxifene Hydrochloride; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism; D013629:Tamoxifen / Q000494:pharmacology*; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
D000970:Antineoplastic Agents; D004965:Estrogen Antagonists; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D011759:Pyrrolidines; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013629:Tamoxifen; D002996:Clomiphene; D020849:Raloxifene Hydrochloride; D009256:Nafoxidine; D004958:Estradiol; C051781:ICI 164384; C014934:trioxifene; D064695:Enclomiphene