Inhibition of cholesterol absorption by HMG-CoA reductase inhibitor.
In subjects with familial hypercholesterolemia cholesterol absorption efficiency was insignificantly reduced during a short-term more consistently during long-term pravastatin treatment. A cholesterol feeding had no effect on LDL cholesterol level but reduced absorption efficiency during a long-term lovastatin treatment.
Miettinen
T A
TA
Second Department of Medicine, University of Helsinki, Finland.
D002791:Cholesterol, Dietary / Q000378:metabolism*; D006538:Heptanoic Acids / Q000494:pharmacology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy* / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D008148:Lovastatin / Q000494:pharmacology*; D009281:Naphthalenes / Q000494:pharmacology*; D017035:Pravastatin
D002791:Cholesterol, Dietary; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009281:Naphthalenes; D008148:Lovastatin; D017035:Pravastatin