title: Heterogeneity of the breakpoint localization in malignant cells with a 9p11 chromosomal abnormality.
abstract: The p11 band of the short arm of chromosome 9 is involved in various cytogenetic alterations occurring in several malignant diseases. Using probes isolated from the 9p11 band in the study of a case of alpha-heavy-chain disease (MAL) with t(9;14)(p11;q32), we studied the DNA from seven malignant cell samples, including four cases of acute lymphoblastic leukemia with tdic(9;12)(p11;p12). Using pulsed-field electrophoresis analysis we demonstrated that the breakpoints were 3-300 kb distant from the original MAL breakpoint without clustering within the subset of leukemias with the tdic(9;12).
authors.affiliation: Laboratory of Immunochemistry and Immunology (INSERM U 108), Hôpital Saint-Louis, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Pellet
authors.forename: J
authors.initials: J
authors.lastname: Hillion
authors.forename: A J
authors.initials: AJ
authors.lastname: Carroll
authors.forename: W M
authors.initials: WM
authors.lastname: Crist
authors.forename: J C
authors.initials: JC
authors.lastname: Brouet
authors.forename: A
authors.initials: A
authors.lastname: Tsapis
mesh_terms: D002869:Chromosome Aberrations; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D002899:Chromosomes, Human, Pair 9; D004586:Electrophoresis / Q000379:methods; D006362:Heavy Chain Disease / Q000235:genetics; D006801:Humans; D007137:Immunoglobulin alpha-Chains; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D007137:Immunoglobulin alpha-Chains