title: Familial narcolepsy in Finland.
abstract: Five patients with narcolepsy-cataplexy (aged 31-69, mean age at onset 15 years) and their 47 relatives were examined. They were interviewed in detail, all patients and 16 relatives (including all symptomatic cases) were examined neurologically and a multiple sleep latency test and HLA-typing were done. One case of narcolepsy and two cases of idiopathic hypersomnia were identified. All the other 45 relatives were symptom-free. The observed rate of familial cases (1/5 for narcolepsy and 2/5 for idiopathic hypersomnia) corresponds the results of other recent studies.
authors.affiliation: Ullanlinna Sleep Disorders Centre, Helsinki, Finland.
authors.forename: C
authors.initials: C
authors.lastname: Hublin
authors.forename: M
authors.initials: M
authors.lastname: Partinen
authors.forename: S
authors.initials: S
authors.lastname: Koskimies
mesh_terms: D000328:Adult; D000368:Aged; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis / Q000235:genetics; D004569:Electroencephalography; D005260:Female; D015802:HLA-DR2 Antigen / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000175:diagnosis / Q000235:genetics*; D009460:Neurologic Examination; D010375:Pedigree; D011930:Reaction Time / Q000235:genetics; D012894:Sleep Stages / Q000235:genetics
chemical_list: D015802:HLA-DR2 Antigen