[The effect of a persistent viral infection on natural antitumor resistance].
The influence of persistent infection with Tahyna virus on the natural antitumor resistance of the hosts was studied in mature mice. The infection was shown to suppress the host natural antitumor resistance. The development of infection was accompanied by a decrease of natural killer cell cytotoxicity against YAC-1 cell line within 7 days after virus inoculation. In this period, the transplantation dose of tumor cells decreased from 10(1.73) to 10(0.82). This indirectly indicates a potential ability of viruses with immunosuppressive activity to increase the frequency of development of malignant tumors.
Mamedov
M K
MK
Semenov
B F
BF
Ozherelkov
S V
SV
Vargin
V V
VV
Treshchalina
E M
EM
Firsova
G A
GA
D000818:Animals; D000831:Animals, Newborn; D002042:Bunyamwera virus; D002044:Bunyaviridae Infections / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D007939:Leukemia L1210 / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D012692:Serial Passage
Vliianie persistentnoĭ virusnoĭ infektsii na estestvennuiu protivoopukholevuiu rezistentnost'.