Failure of blood pressure control by a new combined alpha- and beta-blocking agent (amosulalol) in a patient with pheochromocytoma.
A 42-year-old woman with pheochromocytoma received preoperatively a combined alpha- and beta-adrenoceptor blocking agent, amosulalol, exerting some inhibitory action on both receptors. Severe hypertension and remarkable fluctuation of heart rate occurred following this medication. Although it is claimed currently that a combined blocking agent is useful for the management of this disease, it should be administered with caution.
Yamaguchi
T
T
Department of Urology, School of Medicine, Yamagata University, Japan.
Irisawa
C
C
Watanabe
H
H
Kawamura
S
S
Nakada
T
T
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy* / Q000601:surgery; D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004983:Ethanolamines / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000188:drug therapy; D010673:Pheochromocytoma / Q000188:drug therapy* / Q000601:surgery; D011300:Preoperative Care; D000096926:Benzenesulfonamides
D000959:Antihypertensive Agents; D004983:Ethanolamines; C032473:amosulalol; D000096926:Benzenesulfonamides