Update on the physical-chemical compatibility of cromolyn sodium nebulizer solution: bronchodilator inhalant solution admixtures.
Cromolyn sodium nebulizer solution, 1% (wt/vol), is physically and chemically compatible (stable) for at least 90 minutes when mixed in vitro with a new formulation (metabisulfite-free) of metaproterenol sulfate solution, an inhalant solution of albuterol sulfate or an atropine sulfate inhalant solution. Similarly, cromolyn sodium does not adversely affect the stability of the individual bronchodilator drugs in the admixtures. Since cromolyn sodium is compatible in admixtures with these bronchodilator drugs, adding these agents to cromolyn sodium nebulizer solution should have no negative influence on the effectively administered dose of either active ingredient.
Emm
T
T
Pharmakinetics Laboratories, Baltimore, Maryland.
Metcalf
J E
JE
Lesko
L J
LJ
Chai
M F
MF
D000420:Albuterol / Q000737:chemistry; D001285:Atropine / Q000737:chemistry; D001993:Bronchodilator Agents / Q000737:chemistry*; D002138:Calibration; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004205:Cromolyn Sodium / Q000737:chemistry*; D004338:Drug Combinations; D004355:Drug Stability; D009921:Metaproterenol / Q000737:chemistry; D009330:Nebulizers and Vaporizers
D001993:Bronchodilator Agents; D004338:Drug Combinations; D009921:Metaproterenol; D001285:Atropine; D004205:Cromolyn Sodium; D000420:Albuterol