Effects of platelet-activating factor antagonist SRI 63-441 on endotoxin-induced changes in rat mesenteric microcirculation.
Intravenous injection of E. coli endotoxin 30 mg/kg to rats resulted in a systemic hypotension and rapid decrease in mesenteric arteriolar blood flow velocity (MABFV). The mesenteric arterioles constricted within 3 min followed by a short period of vasodilation after endotoxin administration. Pretreatment with the platelet-activating factor receptor antagonist SRI 63-441 attenuated the endotoxin-induced systemic hypotension and the decrease in MABFV, and abolished the mesenteric vasodilation effect of endotoxin infusion. The results suggest that PAF may be a mediator of endotoxic shock.
Li
S H
SH
Department of Pathophysiology, Second Military Medical University, Shanghai.
Fei
X
X
Gong
X Q
XQ
Wu
Z L
ZL
D000818:Animals; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011806:Quinolinium Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000139:chemically induced / Q000503:physiopathology*; D013152:Splanchnic Circulation / Q000187:drug effects*
D004731:Endotoxins; D010972:Platelet Activating Factor; D011806:Quinolinium Compounds; C050531:SRI 63-441