Radiotherapy of pseudotumors of bone in hemophiliacs with circulating inhibitors to factor VIII.
Pseudotumors of bone in two hemophiliacs with severe factor VIII deficiency and a high level of circulating inhibitors are reported. Both had favorable response to radiation therapy after unsuccessful treatment with factor concentrates and remain free of recurrence at 18-62 months. A review of the literature of cases in which radiotherapy has been used is presented. Radiotherapy in the treatment of pseudotumors of bone in hemophiliacs should be strongly considered, particularly if coagulation factor inhibitors are present.
Castañeda
V L
VL
Department of Pediatrics, University of Texas Health Science Center, San Antonio 78284-7810.
Parmley
R T
RT
Bozzini
M
M
Feldmeier
J J
JJ
D000293:Adolescent; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000532:radiotherapy; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006406:Hematoma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000532:radiotherapy; D006467:Hemophilia A / Q000097:blood / Q000150:complications*; D006801:Humans; D007223:Infant; D008297:Male; D014057:Tomography, X-Ray Computed
D005169:Factor VIII