Effect of activated charcoal on the disposition of sulphadoxine.
Studies were conducted to examine the effect of activated charcoal on the disposition kinetics of sulphadoxine after Fansidar administration. Activated charcoal caused a significant reduction in ka, half-life and AUC0-48hr from 1.4 to 0.7 hr, 256 to 117 hr and 2533 to 1346 mg/l/hr, respectively. Activated charcoal absorbed sulphadoxine effectively in vitro. Sulphadoxine, at a simulated highly toxic dose of 5 mg/ml, showed adsorption percentages of 23.06, 28.66, 41.24, 64 and 100 to amounts of activated charcoal of 12.5, 25, 50, 100 and 250 mg, respectively. The results show that activated charcoal effectively adsorbs sulphadoxine both in vitro and in vivo.
Akintonwa
A
A
Department of Pharmacology, College of Medicine, University of Lagos, Nigeria.
Obodozie
O
O
D000327:Adsorption; D000328:Adult; D002606:Charcoal / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D008297:Male; D013413:Sulfadoxine / Q000737:chemistry / Q000493:pharmacokinetics*
D002606:Charcoal; D013413:Sulfadoxine