Deamination of 2-propyl-1-aminopentane and 2-[(2-propyl)pentylamino] acetamide by amine oxidases: formation of valproic acid.
1. 2-Propyl-1-aminopentane and 2-[(2-propyl)pentylamino]acetamide are deaminated by rat liver monoamine oxidase (MAO) and aorta semicarbazide-sensitive amine oxidase (SSAO). 2. The deaminated product, 2-propylpentaldehyde, is further converted to valproic acid in vitro as well as in vivo. 3. The anticonvulsant action of these two compounds could not be substantiated, because both drugs at relatively low doses caused distinct tremor in mice and rats. 4. Both compounds also potentiate the convulsant effect induced by mercaptopropionic acid.
Yu
P H
PH
Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada.
Davis
B A
BA
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D000588:Amines / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D003641:Deamination; D005998:Glycine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D014635:Valproic Acid / Q000097:blood / Q000378:metabolism*
D000588:Amines; C068588:N-(2-propylpentyl)glycinamide; C068587:2-propyl-1-aminopentane; D014635:Valproic Acid; D006861:Hydrogen Peroxide; D006631:Amine Oxidase (Copper-Containing); D008995:Monoamine Oxidase; D005998:Glycine