title: A biological hypothesis for the FAB classification of acute myeloid leukaemias.
abstract: A biological hypothesis which is based upon the response of AML blast cells to retinoic acid alone and in combinations with other differentiating agents in primary culture, is proposed for the FAB classification of Acute Myeloid Leukaemias. The present biological hypothesis accounts for the biological and clinical observations in AML.
authors.affiliation: Department of Haematology, University of Cambridge Clinical School, UK.
authors.forename: H T
authors.initials: HT
authors.lastname: Hassan
authors.forename: L E
authors.initials: LE
authors.lastname: Zyada
authors.forename: M H
authors.initials: MH
authors.lastname: Ragab
authors.forename: J K
authors.initials: JK
authors.lastname: Rees
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D015470:Leukemia, Myeloid, Acute / Q000145:classification* / Q000188:drug therapy / Q000473:pathology; D008954:Models, Biological; D014212:Tretinoin / Q000494:pharmacology
chemical_list: D014212:Tretinoin