[Sodium sulfapyridazine in new delayed-action bases for the treatment of bacterial conjunctivitis].
Possible preparation of 10 per cent sodium sulfapyridazine ophthalmic drops containing aubazidan, a microbial polysaccharide, providing prolongation of the drops action and stability on the storage was studied. The pharmacokinetic studies showed that aubazidan which is a natural polymer provided high prolongation of the sulfapyridazine effect in the tissues of the anterior part of the eye in rabbits. The prolonged effect was similar to the previously observed effect of the solutions containing synthetic polymers such as 1 per cent polyacrylamide and polyvinyl . Satisfactory tolerance by the rabbit eye tissues of 6-fold daily instillations of the 10 per cent sodium sulfapyridazine solution with aubazidan for the observation period of 1 month was stated. When stored in vials the 10 per cent sodium sulfapyridazine ophthalmic drops with 0.5 per cent of aubazidan preserved the stability for 24 months with respect to the colour, transparency, viscosity, pH and drug content. It was demonstrated with using the agar diffusion method and Staphylococcus aureus, Proteus vulgaris, Escherichia coli and Pseudomonas aeruginosa as the test cultures that sodium sulfapyridazine completely preserved its antimicrobial activity in the presence of aubazidan. The data suggested that clinical trials of the 10 per cent sodium sulfapyridazine solution with 0.2-0.5 per cent of aubazidan were promising in prevention and therapy of bacterial conjunctivitis.
Maĭchuk
Iu F
IuF
Pozdniakov
V I
VI
Kur'iazov
I K
IK
Moldaver
B L
BL
Rusak
A V
AV
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry; D001424:Bacterial Infections / Q000188:drug therapy*; D003231:Conjunctivitis / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000737:chemistry; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry; D011817:Rabbits; D013421:Sulfamethoxypyridazine / Q000008:administration & dosage* / Q000737:chemistry
D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D009883:Ophthalmic Solutions; D011134:Polysaccharides; C048936:aubazidan; D013421:Sulfamethoxypyridazine
Sul'fapiridazin-natriĭ v novykh prolongiruiushchikh osnovakh dlia lecheniia bakterial'nykh kon''iunktivitov.