Estimation of glomerular filtration rate from low-dose injection of iohexol and a single blood sample.
Clearance of a small dose of iohexol (7 g I) was compared with the glomerular filtration rate (GFR) marker 51Cr EDTA in 11 healthy volunteers. The two tracers were injected simultaneously. The plasma concentration of iohexol was measured with x-ray fluorescence technique. Glomerular filtration rate was determined using blood samples drawn three and four hours after injection. An excellent correlation (0.92 less than r less than 0.97) between iohexol clearance and 51Cr EDTA clearance was found. Glomerular filtration rate can be reliably determined with a low dose of iohexol and a single blood sample obtained three hours after the injection in persons with normal serum creatinine. This new method is a good alternative to the methods using radiopharmaceuticals; it causes no radioactive burden to the patients, increases patient comfort, reduces costs, and requires no special license.
Thomsen
H S
HS
Department of Diagnostic Radiology, Herlev Hospital, University of Copenhagen, Denmark.
Hvid-Jacobsen
K
K
D000328:Adult; D002860:Chromium Radioisotopes; D004492:Edetic Acid; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage / Q000493:pharmacokinetics; D007677:Kidney Function Tests / Q000379:methods; D008297:Male
D002860:Chromium Radioisotopes; D007472:Iohexol; D004492:Edetic Acid