title: Clinical characteristics of patients with repeated systemic reactions during specific immunotherapy with hymenoptera venoms. A retrospective study.
abstract: In general, specific immunotherapy with hymenoptera venoms can be considered as safe, but occasionally there are patients who cannot reach the maintenance dose due to repeated systemic reactions (RSR) or who suffer from RSR during maintenance therapy. In a multicenter retrospective study comprising seven departments in Germany, Austria and Switzerland 23 patients with RSR were reported from approximately 3000 patients treated with hymenoptera venoms (bee and wasp venom to approximately equivalent frequency). From these, 22 were allergic to bee venom and only one to vespid venom. In general the clinical symptoms of RSR were milder than the initial reaction. But 4/23 (18%) exhibited cardiovascular reactions up to full shock. Neither anamnestic details, reactivity in skin tests or in vitro tests revealed a special pattern of patients with RSR. In some patients, however, an extremely high reactivity in the skin test was found and may indicate the possibility of further RSR.
authors.affiliation: I. Universitäts-Hautklinik Wien.
authors.forename: B
authors.initials: B
authors.lastname: Rzany
authors.forename: B
authors.initials: B
authors.lastname: Przybilla
authors.forename: R
authors.initials: R
authors.lastname: Jarisch
authors.forename: W
authors.initials: W
authors.lastname: Aberer
authors.forename: R
authors.initials: R
authors.lastname: Dietschi
authors.forename: B
authors.initials: B
authors.lastname: Wüthrich
authors.forename: B
authors.initials: B
authors.lastname: Bühler
authors.forename: P
authors.initials: P
authors.lastname: Frosch
authors.forename: J
authors.initials: J
authors.lastname: Rakoski
authors.forename: H
authors.initials: H
authors.lastname: Kiehn
mesh_terms: D000293:Adolescent; D000328:Adult; D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D001180:Arthropod Venoms / Q000009:adverse effects*; D001514:Bee Venoms / Q000009:adverse effects; D002648:Child; D005260:Female; D006801:Humans; D006927:Hymenoptera; D006967:Hypersensitivity / Q000209:etiology*; D007167:Immunotherapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012882:Skin Tests; D014862:Wasp Venoms / Q000009:adverse effects
chemical_list: D001180:Arthropod Venoms; D001514:Bee Venoms; D014862:Wasp Venoms