[Effects of endotoxin on oxidative metabolism of polymorphonuclear leukocytes].
The influence of endotoxin on rat polymorphonuclear leucocytes (PMN) ability to generate oxygen free radicals (OFR) has been studied by chemiluminescence method. PMNs derived from intact animals were used as a control. PMNs derived from animals with 1.5 h endotoxemia increased OFR production after stimulation by latex. In contrast, PMNs derived from intact animals and preincubated with endotoxin for 1.5 h decreased OFR production after stimulation bw latex. It was proposed that stimulating effect of endotoxin on PMNs in vivo was mediated by plasma components.
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D000818:Animals; D004731:Endotoxins / Q000097:blood / Q000494:pharmacology*; D005609:Free Radicals; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D010100:Oxygen / Q000097:blood*; D051381:Rats; D013997:Time Factors
D004731:Endotoxins; D005609:Free Radicals; D010100:Oxygen
Vliianie éndotoksina na okislitel'nyĭ metabolizm polimorfnoiadernykh leĭkotsitov.