CD8+ T lymphocytes and progression to AIDS in HIV-infected men: some observations.
The relationship between CD8+ lymphocyte counts and progression to AIDS was studied in 340 HIV-1-seropositive men participating in a population-based prospective study. Overall, the relative hazard for developing AIDS during 60 months of observation was slightly elevated (1.08, P = 0.003), indicating an 8% increase in risk of progression for every 100 CD8+ cell count increment. When the data were analyzed in relation to date of diagnosis, the relative hazard was depressed (0.90, P less than 0.001) for the period 6 months prior to diagnosis, but was close to 1.0 for the period 6-36 months prior to diagnosis. These findings suggest a complex relationship between CD8+ cell counts and progression to AIDS, with the possibility that various subsets of the CD8+ compartment play different roles.
Anderson
R E
RE
ViRx Inc., San Francisco, California.
Shiboski
S C
SC
Royce
R
R
Jewell
N P
NP
Lang
W
W
Winkelstein
W
W
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000276:immunology; D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000097:blood*; D016827:CD8 Antigens; D015331:Cohort Studies; D006679:HIV Seropositivity / Q000097:blood / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens