[Variation of substance P-like immunoreactivity in plasma and cerebrospinal fluid in the course of arthritis induced by Freund adjuvant in rats, a model for the study of chronic pain].
Parallel time courses of clinical and behavioural parameters and levels of plasma substance P-like immunoreactivity (SPLI-PI) were studied in arthritic rats (adjuvant induced arthritis, AIA, a chronic pain model). Acute (14 and 21 post-inoculation days,PI) and post-acute (42 days PI) phases of the syndrome were investigated. These data were compared with those obtained in a control situation (inoculation day). In a second experimental series, levels of substance P-like immunoreactivity in cerebrospinal fluid (SPLI-CSF) were determined at the same stages of AIA. In arthritic rats SPLI-PI was strongly enhanced (X4) as early as 14 days PI and remained increased (X4) at all stages studied, whereas SPLI-LCR was significantly increased (X2) only 21 days PI and returned to control levels at 42 days PI. These data suggest that SP could be distributed in two different pools, a peripheral one of inflammatory origin, and a central one which could be more specific to the chronic pain situation.
Calvino
B
B
I.N.S.E.R.M. U. n. 161, Laboratoire de Recherches de Physiopharmacologie du Système nerveux, Paris.
Maillet
S
S
Pradelles
P
P
Besson
J M
JM
Couraud
J Y
JY
D000818:Animals; D001169:Arthritis, Experimental / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D010147:Pain Measurement / Q000379:methods*; D010455:Peptides / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C016116:substance P-like peptides
Variation de l'immunoréactivité de type substance P dans le plasma et le liquide céphalo-rachidien au cours de l'évolution de l'arthrite induite par adjuvant de Freund chez le rat, un modèle d'étude de douleur chronique.