title: Effects of acute alterations in left ventricular loading conditions on peak filling rate in the denervated (transplanted) ventricle.
abstract: Peak filling rate is an indicator of left ventricular (LV) diastolic function. It is influenced by heart rate, loading conditions, sympathetic nervous system activity, ejection fraction and other factors. To determine the effect of altered loading conditions on peak filling rate, independent of heart rate and sympathetic nervous system activity, 12 patients were studied 3 weeks after orthotopic heart transplantation. Plasma catecholamine level, heart rate and ejection fraction were not changed by any maneuver. Nitroglycerin caused a decrease in pulmonary artery wedge pressure (9 +/- 2 to 6 +/- 1 mm Hg, p less than 0.001) and in absolute peak filling rate (46.0 +/- 3.0 to 42.8 +/- 2.5 kcts/s, p less than 0.01), but no change in normalized peak filling rate. Volume infusion increased pulmonary artery wedge pressure (9 +/- 2 to 12 +/- 2 mm Hg, p less than 0.001) and absolute peak filling rate (46.0 +/- 3.0 to 51.5 +/- 5.3 kcts/s, p less than 0.01), but peak filling rate normalized to stroke volume was unchanged. During nitroglycerin and volume infusions, there was a high correlation between changes in pulmonary artery wedge pressure and absolute peak filling rate (r = 0.82, p less than 0.001). With normalization of peak filling rate, these variables correlated less well. With methoxamine, 4 patients demonstrating systolic dysfunction had a decrease in absolute and normalized peak filling rate despite a large increase in pulmonary artery wedge pressure. The other 8 patients without systolic dysfunction had an increase in pulmonary artery wedge pressure with increased absolute but unchanged normalized peak filling rate.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Internal Medicine, University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: D S
authors.initials: DS
authors.lastname: Schulman
authors.forename: B A
authors.initials: BA
authors.lastname: Herman
authors.forename: G
authors.initials: G
authors.lastname: Ziady
authors.forename: T
authors.initials: T
authors.lastname: Edwards
authors.forename: R
authors.initials: R
authors.lastname: Kormos
authors.forename: P S
authors.initials: PS
authors.lastname: Reddy
authors.forename: W P
authors.initials: WP
authors.lastname: Follansbee
authors.forename: B F
authors.initials: BF
authors.lastname: Uretsky
mesh_terms: D006328:Cardiac Catheterization; D003326:Coronary Circulation; D016027:Heart Transplantation; D006352:Heart Ventricles / Q000294:innervation*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008729:Methoxamine / Q000008:administration & dosage; D005996:Nitroglycerin / Q000008:administration & dosage; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D013318:Stroke Volume; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D005996:Nitroglycerin; D008729:Methoxamine