title: Effects of thoracic epidural anesthesia on myocardial pH and metabolism during ischemia.
abstract: The effect of thoracic epidural anesthesia (TEA) on the ischemic myocardium was examined in open-chest dogs anesthetized intravenously. Ischemia induced by brief coronary artery occlusion caused an elevation of the ST segment in epicardial ECG and a reduction in myocardial pH and contractile force. TEA with 0.15 ml/kg of 0.4% bupivacaine solution attenuated an ischemia-induced decrease in myocardial pH and an increase of the ST segment in epicardial ECG. This attenuation was maintained even after the restoration of blood pressure and heart rate, which had been decreased significantly after TEA, to pre-TEA levels, suggesting that a beneficial effect of TEA should not be confined to its hemodynamic changes such as decreased blood pressure and heart rate. In contrast, the subendocardial contents of ATP, creatine phosphate (CP) and lactate were not affected by TEA, either in the presence or the absence of 5 min LAD occlusion. These results suggest that neither hemodynamic nor metabolic changes are responsible for the reduced myocardial ischemic acidosis induced by TEA after brief coronary artery occlusion. The acidosis-saving property of TEA is favorable for the ischemic heart.
authors.affiliation: Department of Anesthesiology, Sapporo Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsuchida
authors.forename: T
authors.initials: T
authors.lastname: Omote
authors.forename: M
authors.initials: M
authors.lastname: Miyamoto
authors.forename: A
authors.initials: A
authors.lastname: Namiki
authors.forename: K
authors.initials: K
authors.lastname: Ichihara
authors.forename: Y
authors.initials: Y
authors.lastname: Abiko
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000767:Anesthesia, Epidural; D000818:Animals; D002045:Bupivacaine; D003327:Coronary Disease / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000378:metabolism; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D013904:Thoracic Vertebrae
chemical_list: D007773:Lactates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D002045:Bupivacaine