Nucleus basalis lesions decrease alpha- and kappa-bungarotoxins binding in rat cortex.
A unilateral ibotenic acid lesion of the nucleus basalis magnocellularis in the rat, which is known to produce a reduction in cortical choline acetyltransferase activity and acetylcholine release, produces a decrease of 125I-alpha-bungarotoxin and 125I-kappa-bungarotoxin binding sites in the frontoparietal cortex of the lesioned hemisphere. This decrease can be observed at two weeks following the lesion and persists for up to twelve weeks. The results suggest that a population of bungarotoxin binding sites may have a presynaptic localization.
Sugaya
K
K
Research Inst. for Biosciences, Science University of Tokyo, Chiba, Japan.
Downen
M
M
Giacobini
E
E
D000818:Animals; D001345:Autoradiography / Q000379:methods; D002038:Bungarotoxins / Q000145:classification / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
D002038:Bungarotoxins