title: Effect of chemicals on glutathione peroxidase of chick liver.
abstract: Chick liver glutathione peroxidase activity was separated into selenium-dependent and selenium-independent enzyme fractions and the effects of chemicals on the activities of each fraction were examined. Clofibrate induced the selenium-dependent enzyme, while phenobarbital, butylhydroxyanisole and trans-stilbene oxide elevated selenium-independent peroxidase activity. A third enzyme, which showed glutathione peroxidase activity toward both hydrogen peroxide and cumene hydroperoxide, was found.
authors.affiliation: Feed Safety Research Division, National Institute of Animal Health, Ibaraki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
mesh_terms: D000818:Animals; D001555:Benzene Derivatives / Q000378:metabolism; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D002645:Chickens / Q000378:metabolism*; D002850:Chromatography, Gel; D002994:Clofibrate / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D013267:Stilbenes / Q000494:pharmacology
chemical_list: D001555:Benzene Derivatives; D013267:Stilbenes; D002083:Butylated Hydroxyanisole; D008748:Methylcholanthrene; D006861:Hydrogen Peroxide; D005979:Glutathione Peroxidase; D002994:Clofibrate; C025906:stilbene oxide; C007164:cumene hydroperoxide; D010634:Phenobarbital