Nitroheterocycle reduction as a paradigm for intramolecular catalysis of drug delivery to hypoxic cells.
Firestone
A
A
Department of Chemistry, University of Rochester, New York 14642.
Mulcahy
R T
RT
Borch
R F
RF
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003110:Colonic Neoplasms / Q000188:drug therapy; D006801:Humans; D009584:Nitrogen / Q000737:chemistry; D009600:Nitroquinolines / Q000378:metabolism / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D014677:Pharmaceutical Vehicles; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009600:Nitroquinolines; D014677:Pharmaceutical Vehicles; D009584:Nitrogen; D010100:Oxygen