Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone OKT3.
An 18-yr-old woman with cystic fibrosis who received a double-lung transplant developed a severe episode of acute lung rejection. Bronchoalveolar lavage and transbronchial biopsy were used to establish the diagnosis. The rejection was refractory to administration of high-dose pulse steroids. OKT3 therapy was successfully used to reverse this episode. This is the first case report of a steroid-resistant double-lung allograft rejection successfully treated with OKT3.
Shennib
H
H
McGill Lung Transplant Program, Montreal General Hospital, Quebec, Canada.
Mercado
M
M
Nguyen
D
D
Ernst
P
P
Lebel
F
F
O'Donovan
M
M
Fraser
R
R
Tchervenkov
C
C
Morin
J F
JF
Mulder
D
D
D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D016040:Lung Transplantation; D008775:Methylprednisolone / Q000627:therapeutic use; D016853:Muromonab-CD3; D011859:Radiography
D000911:Antibodies, Monoclonal; D016853:Muromonab-CD3; D008775:Methylprednisolone