[Anthocyanins and analgesics or a possibility of a new analgetic combination].
Studies were carried out on male white mice to investigate the influence of cantocyans on pain both singly and in combination with the classic analgetics. The following tests were used: the test for narcotic analgetics "hot plate" and the analgetic morphine, administered subcutaneously in sub- and nonanalgetic doses (10 and 5 mg/kg of body mass respectively); the test for nonnarcotic analgetics-chemical peritoneal stimulation with 3% of acetic acid and the analgetic analgin, administered subcutaneously in a nonanalgetic dose (100 mg/kg of body mass). The results from the experiments showed that antocyans did not possess its own analgetic effect in both of the experimental models. However their combination with morphine and analgin, administered in noneffective analgetic doses, caused manifested analgetic effect of the combinations in all used doses of antocyans (50, 100 and 200 mg/kg of body mass). The possibility for therapeutic usage of analgetic combinations of antocyans and narcotic and nonnarcotic analgetics is discussed.
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D000700:Analgesics / Q000008:administration & dosage; D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage; D004177:Dipyrone / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage; D010146:Pain / Q000188:drug therapy
D000700:Analgesics; D000872:Anthocyanins; D004338:Drug Combinations; D004177:Dipyrone; D009020:Morphine
Antotsiani i analgetitsi ili edna vŭzmozhnost za nova analgetichna kombinatsiia.