title: Serum pepsinogen I concentrations in peptic ulcer patients in relation to ulcer location and stage.
abstract: To investigate the relation of the serum group I pepsinogen (PG I) concentration to the location of gastric ulcers and chronicity of peptic ulcers, ulcer patients (n = 322) were compared with endoscopically normal subjects (n = 174). The mean PG I concentration was significantly higher in male control subjects (n = 90) than in female control subjects (n = 84). In male patients with ulcers in the duodenum (n = 69), antrum (n = 34), or angulus portion (the lower third of the body; n = 83), the mean serum PG I concentration was significantly higher than in the control subjects but in patients with an ulcer in the upper body (n = 49) it was similar to control values. Men with active or healing ulcers (n = 149) showed a significantly higher serum PG I concentration than those with scarred lesions (n = 86) when the abnormality was located in either the upper body or in the angulus portion. For female patients (n = 87), the results were similar. These results suggest that serum PG I concentrations reflect the stages of activity of peptic ulcer.
authors.affiliation: Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Mine
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
authors.forename: N
authors.initials: N
authors.lastname: Mishima
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000201:enzymology* / Q000473:pathology; D004386:Duodenum / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood*; D012737:Sex Factors; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000201:enzymology* / Q000473:pathology
chemical_list: D010435:Pepsinogens