Norepinephrine-stimulated phosphatidylinositol metabolism in genetically epilepsy-prone and kindled rats.
Genetically epilepsy-prone rats (GEPR-9) and kindled rats have reduced noradrenergic function. In the present study, norepinephrine-stimulated accumulation of inositol phosphates was reduced in cerebral cortex of GEPR-9 and kindled rats when compared to control and non-kindled rats, respectively. No such reduction was found in amygdala/pyriform cortex and hippocampus. These results support the hypothesis that cortical noradrenergic and associated second messenger systems are impaired in epilepsy.
Yourick
D L
DL
Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
LaPlaca
M C
MC
Meyerhoff
J L
JL
D000818:Animals; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism*; D007696:Kindling, Neurologic; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D009994:Osmolar Concentration; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D010716:Phosphatidylinositols; D009638:Norepinephrine