title: TGF-beta: upregulator of HIV replication in macrophages.
abstract: TGF-beta at physiological concentrations, when added to monocyte-derived macrophages following HIV1 infection, has an enhancing effect upon the rate of virus production. This effect is observed with the monocytotropic isolate ADA, as well as with HIV1 IIIB, which poorly replicates in macrophages.
authors.affiliation: Ciba-Geigy, Ltd., Pharma Research, Basel, Switzerland.
authors.forename: J K
authors.initials: JK
authors.lastname: Lazdins
authors.forename: T
authors.initials: T
authors.lastname: Klimkait
authors.forename: E
authors.initials: E
authors.lastname: Alteri
authors.forename: M
authors.initials: M
authors.lastname: Walker
authors.forename: K
authors.initials: K
authors.lastname: Woods-Cook
authors.forename: D
authors.initials: D
authors.lastname: Cox
authors.forename: G
authors.initials: G
authors.lastname: Bilbe
authors.forename: R
authors.initials: R
authors.lastname: Shipman
authors.forename: N
authors.initials: N
authors.lastname: Cerletti
authors.forename: G
authors.initials: G
authors.lastname: McMaster
mesh_terms: D002454:Cell Differentiation; D002478:Cells, Cultured; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008264:Macrophages / Q000166:cytology / Q000382:microbiology*; D009000:Monocytes / Q000166:cytology; D016212:Transforming Growth Factor beta / Q000502:physiology*; D015854:Up-Regulation; D014779:Virus Replication
chemical_list: D016212:Transforming Growth Factor beta