[Minimal residual disease in leukemia].
Recently, detection of the minimal residual disease (MRD) has become possible by polymerase chain reaction (PCR) using leukemia specific DNA or mRNA sequences originated from t(9; 22), t(1; 19) and t(14; 18) translocations, T cell receptor or immunoglobulin CDRIII. This method made possible to detect one leukemic cell out of 10(4)-10(5) cells, and the presence of MDR became clear during complete remission after chemotherapy or bone marrow transplantation. This suggests the usefulness of this method in the treatment of leukemia.
Morishima
Y
Y
First Dept. of Internal Medicine, Nagoya University School of Medicine, Japan.
D000911:Antibodies, Monoclonal; D016026:Bone Marrow Transplantation; D002904:Chromosomes, Human, 21-22 and Y; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology; D012333:RNA, Messenger / Q000032:analysis; D014178:Translocation, Genetic
D000911:Antibodies, Monoclonal; D004273:DNA, Neoplasm; D012333:RNA, Messenger