[The protective effect of hemagglutinin-specific monoclonal antibodies in experimental influenza infection].
Experiments in mice showed a high protective effect of monoclonal antibodies (MCA) to influenza A/Krasnodar/101/59 (H2N2) virus hemagglutinin, possessing neutralizing activity in ovo. A 100% protective effect was observed upon intranasal administration of MCA Kp/101-3 48 hours before infection, and 90% effect upon administration of MCA 96 hours before infection. A 100% therapeutic effect was observed upon intranasal administration of MCA Kp/101-3 less than 24 hours postinfection and 70% therapeutic effect was achieved by administration of these MCA 48-72 hours postinfection.
Nagieva
F G
FG
Krasnova
N I
NI
Nikulina
V G
VG
Andzhaparidze
O G
OG
D000818:Animals; D000911:Antibodies, Monoclonal / Q000302:isolation & purification / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000302:isolation & purification / Q000627:therapeutic use*; D000918:Antibody Specificity / Q000276:immunology*; D004353:Drug Evaluation, Preclinical; D006385:Hemagglutination Inhibition Tests; D006389:Hemagglutinins, Viral / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology*; D008168:Lung / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D013997:Time Factors
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D006389:Hemagglutinins, Viral
Protektivnyĭ éffekt gemaggliutininspetsifichnykh monoklonal'nykh antitel pri éksperimental'noĭ grippoznoĭ infektsii.