[Presence of specific mutation of Ha-ras oncogene in skin tumors of mice induced under different experimental conditions].
The mutation was revealed with substitution of A for T in the second position of the 61 Ha-ras oncogene codon in the DNA of 31 skin tumours (26 papillomas and 5 carcinomas) and in 23 mice treated with 12-O-tetradecanoyl phorbol-13-acetate (TPA). Part of these mice were F progeny (n-6) and F progeny (n-4) following DMBA administration during pregnancy, another part F progeny (n-5) following ENU action on males prior to mating, the rest mice (n-3) did not undergo additional actions. The mutation under study was revealed only in 3 out of 5 papillomas and in all 5 carcinomas of mice subjected to DMBA administration during pregnancy.
Loktionov
A S
AS
Popovich
I G
IG
Zabezhinskiĭ
M A
MA
Anisimov
V N
VN
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced / Q000235:genetics*; D003062:Codon; D005260:Female; D011905:Genes, ras; D008297:Male; D051379:Mice; D009154:Mutation; D010212:Papilloma / Q000139:chemically induced / Q000235:genetics*; D011247:Pregnancy; D012878:Skin Neoplasms / Q000139:chemically induced / Q000235:genetics*; D013755:Tetradecanoylphorbol Acetate
D003062:Codon; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate
Prisutstvie spetsificheskoĭ mutatsii onkogena Ha-ras v opukholiakh kozhi mysheĭ, indutsirovannykh v razlichnykh éksperimental'nykh usloviiakh.