Cartilage research, biochemical, histologic, and immunohistochemical markers in cartilage, and animal models of osteoarthritis.
Over the past 20 years, there has been growing interest in the biochemistry, molecular biology, and physiology of cartilage. In the last year, there have been considerable advances in the understanding of the processes involved in the anabolism and breakdown of cartilage and the influence of cytokines and growth factors. This review addresses the area of cartilage research, the investigation of markers of cartilage, and the biochemical mechanisms involved in the development of osteoarthritis in animal models. The volume of cartilage research is extensive, and due to the nature of this review, I concentrate on work that is directly related to the anabolic and catabolic response of cartilage to various agents and to those investigations of cartilage with particular relevance to the development of osteoarthritis both in experimental models and in humans.
Carney
S L
SL
Lilly Research Centre Ltd., Eli Lilly & Co., Windlesham, Surrey, UK.
D000818:Animals; D015415:Biomarkers; D002356:Cartilage / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002645:Chickens; D004195:Disease Models, Animal; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D010003:Osteoarthritis / Q000473:pathology*; D011817:Rabbits
D015415:Biomarkers