Autoimmune haemolytic anaemia associated with low-titre anti-i cold agglutinins in a Nigerian. A case report.
A case of autoimmune haemolytic anaemia due to low-titre anti-i cold agglutinin in a Nigerian is described. The patient presented with chronic haemolytic anaemia with a positive direct antiglobulin test, the cells reacting with anticomplement (anti-C3). Further tests showed that the antibody was a low titre (1 in 512) cold anti-i antibody with a wide thermal amplitude. The case reported appears to be the first case of cold haemagglutinin disease in a Nigerian.
Obi
G O
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Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Enugu.
D000328:Adult; D000373:Agglutinins / Q000276:immunology*; D000744:Anemia, Hemolytic, Autoimmune / Q000208:ethnology / Q000276:immunology*; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D044383:Black People; D003080:Cold Temperature; D003450:Cryoglobulins; D005260:Female; D006801:Humans
D000373:Agglutinins; D000888:Antibodies, Anti-Idiotypic; D003450:Cryoglobulins; C029443:cold agglutinins