Inhibition of urease activity but not growth of Helicobacter pylori by acetohydroxamic acid.
The in vitro effects of acetohydroxamic acid (AHA), a potent urease inhibitor, were studied to determine the effect on the urease activity and growth of 38 strains of Helicobacter pylori. AHA in concentrations of 50-1000 mg/l had a noticeably reversible inhibitory effect on the urease activity of the organism but no effect on growth.
Goldie
J
J
Department of Laboratory Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Veldhuyzen van Zanten
S J
SJ
Jalali
S
S
Richardson
H
H
Hunt
R H
RH
D004305:Dose-Response Relationship, Drug; D016480:Helicobacter pylori / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D006877:Hydroxamic Acids / Q000494:pharmacology*; D014510:Urease / Q000037:antagonists & inhibitors* / Q000378:metabolism
D006877:Hydroxamic Acids; C006358:acetohydroxamic acid; D014510:Urease