title: Effects of prenatal ethanol exposure on learned persistence and hippocampal neuroanatomy in infant, weanling and adult rats.
abstract: The present experiment examined whether deficits in learned persistence, previously seen in 15-day-old infant rats prenatally exposed to ethanol, would be present in weanling and adult animals. Three prenatal treatments, EtOH, PAIR-FED, and LAB CHOW, were combined factorially with partial (PRF) or continuous (CRF) reinforcement training followed by extinction, at 21 days or 6 months of age. The results at 21 days were virtually the same as our earlier findings for 15-day-olds: we did not find the higher level of persistence in PRF-trained EtOH pups relative to CRF-trained EtOH pups, which characterizes the partial reinforcement extinction effect (PREE). The EtOH-PRF and EtOH-CRF animals extinguished at about the same rate, both faster than PRF controls. However, when tested as adults, the EtOH-exposed animals showed a normal PREE, with no deficits relative to controls. An analysis of CA1 pyramidal cells in midtemporal hippocampus demonstrated no significant differences in cell density or in CA1 area among the 3 prenatal diet conditions; however, there was a significant reduction in cell density with age for all groups. These results suggest that a developmental delay, unrelated to these neuroanatomical measures, is responsible for the lack of persistence in young rats exposed prenatally to ethanol.
authors.affiliation: Department of Psychology, University of Texas, Austin 78712.
authors.forename: N J
authors.initials: NJ
authors.lastname: Lobaugh
authors.forename: T
authors.initials: T
authors.lastname: Wigal
authors.forename: P L
authors.initials: PL
authors.lastname: Greene
authors.forename: J L
authors.initials: JL
authors.lastname: Diaz-Granados
authors.forename: A
authors.initials: A
authors.lastname: Amsel
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects; D004032:Diet; D000431:Ethanol / Q000633:toxicity*; D005108:Extinction, Psychological / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D006624:Hippocampus / Q000033:anatomy & histology* / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule
chemical_list: D000431:Ethanol