title: 6-Pentadecylsalicylic acid: an antithrombin component isolated from the stem of Rhus semialata var. roxburghii.
abstract: Bioassay-directed fractionation of the n-hexane extract of the stem of Rhus semialata Murr. var. roxburghii DC (Anacardiaceae) has led to the isolation of 6-pentadecylsalicylic acid. It showed antithrombin activity at 50 micrograms/ml in the amidolytic method. It also prolonged the clotting time in a dose-dependent manner in the clotting assay of thrombin-fibrinogen interaction.
authors.affiliation: Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taichung, Taiwan.
authors.forename: S C
authors.initials: SC
authors.lastname: Kuo
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
authors.forename: L G
authors.initials: LG
authors.lastname: Lee
authors.forename: T H
authors.initials: TH
authors.lastname: Chiu
authors.forename: T S
authors.initials: TS
authors.lastname: Wu
authors.forename: S C
authors.initials: SC
authors.lastname: Huang
authors.forename: J B
authors.initials: JB
authors.lastname: Wu
authors.forename: T Y
authors.initials: TY
authors.lastname: Shieh
authors.forename: R J
authors.initials: RJ
authors.lastname: Chang
authors.forename: T C
authors.initials: TC
authors.lastname: Chou
mesh_terms: D000595:Amino Acid Sequence; D048729:Anacardic Acids; D000818:Animals; D000991:Antithrombins / Q000302:isolation & purification / Q000378:metabolism; D002417:Cattle; D002863:Chromogenic Compounds / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D012459:Salicylates / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D048729:Anacardic Acids; D000991:Antithrombins; D002863:Chromogenic Compounds; D012459:Salicylates; C088115:anacardic acid