Comparison of a DNA probe assay with culture for the detection of Chlamydia trachomatis.
A new DNA probe assay (PACE 2, Gen-probe) was compared with cell culture for the detection of Chlamydia trachomatis in 909 women attending the Royal Women's Hospital, Melbourne, Victoria. The DNA probe assay had a sensitivity of 86.2%, a specificity of 99.9% and a positive predictive value of 96.2% in a population with 3.2% prevalence, indicating that it may be a suitable alternative to culture for the detection of C. trachomatis in specimens from the genital tract.
Lees
M I
MI
Microbiology Department, Royal Women's Hospital, Victoria, Australia.
Newnan
D M
DM
Garland
S M
SM
D002478:Cells, Cultured; D002584:Cervix Uteri / Q000166:cytology / Q000382:microbiology; D002690:Chlamydia Infections / Q000175:diagnosis*; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D015342:DNA Probes; D005260:Female; D006801:Humans; D008027:Light; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis
D015342:DNA Probes