title: Lowering of HDL2-cholesterol and lipoprotein A-I particle levels by increasing the ratio of polyunsaturated to saturated fatty acids.
abstract: The protective role of high-density lipoproteins (HDLs) has been attributed to the subfractions HDL2 (according to the density) and lipoprotein A-I (LpA-I) (according to the composition in apolipoproteins). We investigated the effect of a high ratio of polyunsaturated to saturated fatty acids (P:S) on these subfractions in a homogeneous group of young adult males. Two prescribed diets were consumed successively at the subjects' homes for 3 wk each in a random order; one diet contained 70 g butter (P:S 0.2, diet B), the other contained 70 g sunflower margarine (P:S 1.1, diet M). Total calorie, fat, and cholesterol intakes were similar for the two diets. Cholesterol and apolipoprotein B in serum and in low-density lipoproteins (LDLs) were lower with diet M than with diet B. However, significant decreases in protective subfractions of HDL, HDL2, and LpA-I were observed. This undesirable effect of the diet with a high P:S could cancel the benefits of lowering the LDL-cholesterol concentrations.
authors.affiliation: INSERM U286, Faculté X Bichat, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Fumeron
authors.forename: L
authors.initials: L
authors.lastname: Brigant
authors.forename: H J
authors.initials: HJ
authors.lastname: Parra
authors.forename: J M
authors.initials: JM
authors.lastname: Bard
authors.forename: J C
authors.initials: JC
authors.lastname: Fruchart
authors.forename: M
authors.initials: M
authors.lastname: Apfelbaum
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000517:prevention & control*; D004041:Dietary Fats / Q000008:administration & dosage*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male
chemical_list: D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D008075:Lipoproteins, HDL