title: GTP-dependent membrane fusion during hepatocarcinogenesis and liver regeneration.
abstract: Rough microsomes were isolated from homogenates of livers of rats bearing hepatomas as well as from homogenates of livers of rats 24 and 48 h after partial hepatectomy. When incubated in the presence of GTP in a cell-free system to assay membrane fusion these membranes were observed to have a greater capacity (1.4 to 5 fold) for GTP-dependent fusion than homologous membranes from control non-proliferating liver tissue. The enhanced GTP-dependent membrane fusion may reflect changes in membrane properties related to cell proliferation.
authors.affiliation: Département d'anatomie, Faculté de médecine, Université de Montréal, Québec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Paiement
authors.forename: J M
authors.initials: JM
authors.lastname: Dominguez
authors.forename: A
authors.initials: A
authors.lastname: Guénette
authors.forename: L
authors.initials: L
authors.lastname: Roy
mesh_terms: D016604:Aflatoxin B1; D000348:Aflatoxins; D000818:Animals; D002273:Carcinogens; D002455:Cell Division / Q000187:drug effects; D004261:DNA Replication; D006160:Guanosine Triphosphate / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D008099:Liver / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D008115:Liver Regeneration; D008297:Male; D008561:Membrane Fusion / Q000187:drug effects*; D008854:Microscopy, Electron; D008862:Microsomes, Liver / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000348:Aflatoxins; D002273:Carcinogens; D006160:Guanosine Triphosphate; D016604:Aflatoxin B1