PUVA-induced lymphomatoid papulosis in a patient with mycosis fungoides.
The occurrence of lymphomatoid papulosis in patients with cutaneous lymphoma, particularly mycosis fungoides, has been described in medical literature. A 68-year-old woman affected by mycosis fungoides in the plaque stage noticed that multiple papulonodular lesions of lymphomatoid papulosis developed suddenly after a few sessions of PUVA therapy. The PUVA induction of lymphomatoid papulosis was confirmed by the appearance of new lesions after a second cycle of PUVA exposure on a limited area of the body. Complete regression of all PUVA-induced lymphomatoid papulosis lesions was achieved within a few weeks with oral prednisone and topical steroids. During the entire treatment the patches and plaques of mycosis fungoides persisted unchanged.
Wolf
P
P
Department of Dermatology, University of Graz, Austria.
Cerroni
L
L
Smolle
J
J
Kerl
H
H
D000368:Aged; D004804:Eosinophils / Q000473:pathology; D004890:Erythema / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006470:Hemorrhage / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D009182:Mycosis Fungoides / Q000188:drug therapy*; D011701:PUVA Therapy / Q000009:adverse effects*; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy*