title: [New molecular mechanism of the blockade of neuronal N-cholinoreceptors].
abstract: Antioxidants and disulphide bond reducing agents have shown the central N-cholinolytic effect and prevented nicotinic-induced contraction of isolated smooth muscle preparation (ISMP). N-cholinolytic pediphen and antioxidant ionol reduced disulphide bond in the supernatant of mouse brain, but sulphydryl-oxidant agents 5'5-Dithiobis (2-nitrobenzoic acid) abolished N-cholinolytic effect of pediphen on ISMP. It is concluded that reduction of disulphide bond of N-cholinoceptor is a molecular mechanism of its blockade.
authors.forename: N N
authors.initials: NN
authors.lastname: Churaev
authors.forename: E P
authors.initials: EP
authors.lastname: Zatsepin
authors.forename: O I
authors.initials: OI
authors.lastname: Dobrotina
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D004220:Disulfides / Q000378:metabolism; D066298:In Vitro Techniques; D051379:Mice; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D009538:Nicotine / Q000037:antagonists & inhibitors; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects* / Q000378:metabolism; D013053:Spectrophotometry; D013565:Sympatholytics / Q000494:pharmacology*
chemical_list: D004220:Disulfides; D011950:Receptors, Cholinergic; D013565:Sympatholytics; D002084:Butylated Hydroxytoluene; D009538:Nicotine
vernacular_title: Novyĭ molekuliarnyĭ mekhanizm blokady neĭronal'nykh N-kholinoretseptorov.