Specific hippocampal lesions indicate the presence of sulfonylurea binding sites associated to ATP-sensitive K+ channels both post-synaptically and on mossy fibers.
The density of glibenclamide (GB) binding sites decreases considerably in the dentate gyrus (greater than 80%), the CA1 field (approximately 75%) and the stratum lucidum of CA3 field (approximately 70%) after intradentate colchicine injections in rat hippocampus. The density of GB receptors is unchanged in kainic acid damaged hippocampus. These data show that GB binding sites associated to adenosine triphosphate-sensitive K+ channels are mainly located in granular cells in both pre- and post-synaptic positions. They are present in mossy fibers.
Mourre
C
C
Institut de Pharmacologie moléculaire et cellulaire, Valbonne, France.
Widmann
C
C
Lazdunski
M
M
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000187:drug effects / Q000502:physiology; D003078:Colchicine / Q000494:pharmacology*; D005905:Glyburide / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D007608:Kainic Acid / Q000494:pharmacology*; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D011712:Pyramidal Tracts / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000187:drug effects / Q000378:metabolism*; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D014316:Tritium
D015221:Potassium Channels; D011955:Receptors, Drug; C067662:glibenclamide receptor; D014316:Tritium; D007608:Kainic Acid; D003078:Colchicine; D005905:Glyburide