Cytotoxic activity of di-n-butyltin(IV)(X-A-B-Y) compounds related to salicylic acid against human tumour cells.
A series of di-n-butyltin(IV) compounds of the type di-n-butyltin(IV)(X-A-B-Y) with the (X-A-B-Y) being related to salicylic acid was tested in vitro for cytotoxic activity against tumour cells of the human A 204, MCF-7, T24, WiDr and IgR-37 cell lines using the PIT method. In each cell line the di-n-butyltin(IV) compounds displayed similar activity. As compared to cisplatin, the compounds were 4- to 10-fold more effective against A 204, MCF-7 and T24 tumour cells and slightly more effective against WiDr cells. The effectiveness against IgR-37 cells was similar for cisplatin and di-n-butyltin (IV) compounds.
Ross
M
M
Medical Department, Pharmachemie B.V., Haarlem, The Netherlands.
Gielen
M
M
Lelieveld
P
P
De Vos
D
D
D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009947:Organotin Compounds / Q000494:pharmacology*; D012459:Salicylates / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D009947:Organotin Compounds; D012459:Salicylates; C056189:di-n-butyltin; C020735:dibutyldichlorotin