Investigation of blood group A substance in the circulation of a patient with ovarian cyst.
Blood group substance was investigated in serum, cyst fluid and ascites of a patient with mucinous cystadenoma of the ovary. The patient's blood group was A, Le(a-b+), secretor. The serum contained so abnormally large amounts of A substance that it was difficult to determine the ABO blood of the patient's red cells. Using neutralization of anti-A, the ovarian cyst fluid was estimated to contain about 4,000 and 1,500 times as much substance as the serum before removal of the cyst and ascites, respectively. The A substance in serum reverted to a normal level 13 days after removal of the cyst. Gel infiltration analysis of the serum, ascites and ovarian cyst fluid showed the presence of similar A substance with a molecular weight ranging from one to several millions. These data indicate that A substance from the ovarian cyst entered the blood stream, and disappeared from it after the cyst was removed (half-life: 1 day).
Kominato
Y
Y
Department of Legal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Fujikura
T
T
Takizawa
H
H
Nishino
K
K
Soeda
Y
Y
Izumi
R
R
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D001202:Ascitic Fluid / Q000276:immunology; D001788:Blood Grouping and Crossmatching; D001826:Body Fluids / Q000276:immunology; D005260:Female; D006801:Humans; D007519:Isoantigens / Q000302:isolation & purification; D010048:Ovarian Cysts / Q000097:blood* / Q000276:immunology
D000017:ABO Blood-Group System; D007519:Isoantigens