Further evidence of lipid peroxidation in post-enteropathic haemolytic-uraemic syndrome.
Lipid peroxidation may play a role in the pathogenesis of the haemolytic-uraemic syndrome (HUS). Thirteen children with the post-enteropathic form of HUS were studied using conjugated diene lipids as markers of in vivo lipid peroxidation. Levels of total conjugated diene lipids and 9,11-linoleic acid, the principal conjugated diene in human plasma, were greater in the acute phase of this disorder than in controls. The ratio of plasma vitamin E to lipid was lower than that in children with other renal diseases, and the expected positive correlation between vitamin E and lipids did not hold for HUS patients. These data provide further evidence of lipid peroxidation in HUS and a disturbance in the metabolism of the principal lipid-bound anti-oxidant vitamin E.
Situnayake
R D
RD
Clinical Investigation Unit, Dudley Road Hospital, Birmingham, UK.
Crump
B J
BJ
Thurnham
D I
DI
Taylor
C M
CM
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007410:Intestinal Diseases / Q000378:metabolism*; D008041:Linoleic Acids / Q000097:blood; D015227:Lipid Peroxidation; D008297:Male; D014280:Triglycerides / Q000097:blood; D014807:Vitamin D / Q000097:blood; D014810:Vitamin E / Q000097:blood
D008041:Linoleic Acids; D014280:Triglycerides; D014807:Vitamin D; D014810:Vitamin E; D002784:Cholesterol