[Effects of phospholipid platelet activation factor on proliferation of B-lymphocytes of the peripheral blood of healthy donors and patients with bronchial asthma].
The influence of the phospholipid platelet activation factor (PAF) was studied on pokeweed mitogen (PWM)-stimulated proliferation of peripheral blood lymphocytes in patients with bronchial asthma and normal subjects. It was found that PAF exerts dose-dependent activation with following suppression mainly on B-cells after its action on the whole population of lymphocytes activated by PWM. Besides, the influence of PAF on lymphocyte proliferation seemed to be mediated by monocytes since removal of monocytes from the whole population of mononuclear cells abolished the lymphocyte activation induced by PWM. Indomethacin inhibits lymphocyte proliferation activation induced by PAF. The results indicate that PAF has an effect on the IgE and IgG synthesis by blood B-lymphocytes in patients with bronchial asthma.
Orlov
S M
SM
Vlasov
A A
AA
Savel'eva
V F
VF
Lipatkina
L Iu
LIu
Kulikov
V I
VI
D000328:Adult; D001249:Asthma / Q000276:immunology*; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002455:Cell Division; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007213:Indomethacin / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000494:pharmacology*; D011043:Pokeweed Mitogens / Q000494:pharmacology
D007074:Immunoglobulin G; D010972:Platelet Activating Factor; D011043:Pokeweed Mitogens; D007073:Immunoglobulin E; D007213:Indomethacin
Vliianie fosfolipidnogo faktora aktivatsii trombotsitov na proliferatsiiu B-limfotsitov perifericheskoĭ krovi zdorovykh donorov i bol'nykh bronkhial'noĭ astmoĭ.