Defective Fc receptor-mediated clearance in patients with primary biliary cirrhosis.
Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). The mean half-life of the sensitized erythrocytes was significantly prolonged in patients with primary biliary cirrhosis (85 +/- 25 minutes; P less than 0.001) compared with the corresponding value in patients with alcoholic cirrhosis (16 +/- 2 minutes) and healthy reference individuals (20 +/- 5 minutes), respectively. No correlation between clearance rate and age, liver histopathology, or serum levels of bilirubin, aminotransferases, immunoglobulin G, immunoglobulin A, and Clq binding or C3-containing immune complexes was found. The results presented here indicate a profound disturbance of Fc receptor-mediated immune clearance function in patients with primary biliary cirrhosis.
Ekdahl
K N
KN
Department of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala, Sweden.
Lööf
L
L
Nyberg
A
A
Nilsson
U R
UR
Nilsson
B
B
D000936:Antigen-Antibody Complex / Q000276:immunology; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007074:Immunoglobulin G; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology; D008105:Liver Cirrhosis, Biliary / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012157:Mononuclear Phagocyte System / Q000276:immunology; D010587:Phagocytosis; D011961:Receptors, Fc / Q000276:immunology*
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D011961:Receptors, Fc