title: Comparison of pertussis toxin (PT)-neutralizing activities and mouse-protective activities of anti-PT mouse monoclonal antibodies.
abstract: An assay of neutralizing activity against CHO cell-clustering activity, one of the most common assays for anti-pertussis toxin antibodies, did not correlate well with an assay of the protective activities of monoclonal antibodies. A better correlation between neutralization of leukocytosis-promoting or islet-activating activity and mouse protection against aerosol challenge was seen.
authors.affiliation: Department of Applied Immunology, National Institute of Health, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: I
authors.initials: I
authors.lastname: Ohishi
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D006224:Cricetinae; D007964:Leukocytosis / Q000139:chemically induced; D051379:Mice; D037342:Pertussis Toxin; D010566:Virulence Factors, Bordetella / Q000276:immunology* / Q000633:toxicity; D014917:Whooping Cough / Q000517:prevention & control*
chemical_list: D000911:Antibodies, Monoclonal; D010566:Virulence Factors, Bordetella; D000246:Adenosine Diphosphate Ribose; D037342:Pertussis Toxin