title: Successful treatment of acquired factor VIII antibody by extracorporeal immunoadsorption.
abstract: We report the successful treatment of a 59-year-old woman with acquired factor VIII inhibitor. The patient who had an extensive leg hematoma with a resultant neurologic defect was treated with extracorporeal immunoadsorption (IA) using protein A-Sepharose, factor VIII concentrates, azathioprine, and methyl-prednisolone. Extracorporeal IA reduced the titers of the inhibitor so that factor VIII concentrates could raise the level of factor VIII coagulant activity and stop the bleeding.
authors.affiliation: Laboratoire d'Hémobiologie, Institut Pasteur, INSERM U-331, Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Négrier
authors.forename: M
authors.initials: M
authors.lastname: Dechavanne
authors.forename: F
authors.initials: F
authors.lastname: Alfonsi
authors.forename: P J
authors.initials: PJ
authors.lastname: Tremisi
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood / Q000628:therapy*; D005169:Factor VIII / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006406:Hematoma / Q000209:etiology / Q000276:immunology; D006801:Humans; D007163:Immunosorbent Techniques; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D005169:Factor VIII