A dose-response study examining the effects of ritanserin on human slow wave sleep.
This study investigated the effects of placebo, 1 mg, 3 mg, 10 mg and 30 mg ritanserin and 10 mg diazepam on human sleep. Twelve normal volunteers participated in this randomized, double-blind, placebo-controlled cross-over sleep study. A clear dose-response relationship was found for ritanserin with higher doses evoking increased duration of slow wave sleep.
Idzikowski
C
C
Clinical Pharmacology Unit, Janssen Research Foundation, Wantage, Oxon.
Mills
F J
FJ
James
R J
RJ
D000293:Adolescent; D000328:Adult; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D016713:Ritanserin; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D010880:Piperidines; D016713:Ritanserin; D003975:Diazepam