Effects of the new anti-ulcer agent 12-sulfodehydroabietic acid monosodium salt on healing of acetic acid-induced gastric ulcers in rats.
The macroscopic and microscopic effects of 12-sulfodehydroabietic acid monosodium salt (TA-2711, CAS 86408-72-2) on the healing of acetic acid-induced gastric ulcers in rats were compared with those of sucralfate and carbenoxolone. Test compounds were given orally twice a day for 10 consecutive days from the day after the injury with glacial acetic acid. TA-2711 (50 and 100 mg/kg) dose-dependently decreased the macroscopic ulcer index (mm2). In addition, at a dose of 100 mg/kg, this drug decreased the length of mucosal defect in the ulcerated region and increased the mucosal regeneration index estimated by microscopic observation. Furthermore, the mucosa surrounding the ulcerated area and the regenerated epithelium in the TA-2711 administered group contained more PAS (periodic acid-Schiff)-positive material than those in the control group. On the other hand, neither sucralfate nor carbenoxolone (100 mg/kg) showed any significant effects on ulcer healing.
Onoda
Y
Y
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
Iwasaki
H
H
Magaribuchi
T
T
Tamaki
H
H
D045784:Abietanes; D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002229:Carbenoxolone / Q000627:therapeutic use; D004224:Diterpenes / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D013392:Sucralfate / Q000627:therapeutic use
D045784:Abietanes; D000085:Acetates; D000897:Anti-Ulcer Agents; D004224:Diterpenes; C061681:ecabet; D013392:Sucralfate; D002229:Carbenoxolone; D019342:Acetic Acid