title: [Lung lesions of drug origin accompanied by hypereosinophilia].
abstract: A study is presented of 16 patients with eosinophilic lesions of the lungs due to drug treatment. The disease was characterized by a reduction of T-lymphocytes, inhibition of the enzymatic activity of leucocytes, dysproteinemia with hypergammaglobulinemia and reduction of IgG concentration. Patients with a high eosinophilia in the blood revealed a severe course of the disease with polysystemic involvement. The therapeutic effect was achieved only by means of prednisolone monotherapy. At the remote period they developed as a rule bronchial asthma. Patients with moderate eosinophilia showed a more favourable course, treatment proved successful with employment of nonsteroid anti-inflammatory agents, antihistaminic drugs in combination with nondrug treatment.
authors.forename: G V
authors.initials: GV
authors.lastname: Trubnikov
mesh_terms: D004205:Cromolyn Sodium / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010406:Penicillins / Q000009:adverse effects; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D013424:Sulfanilamides / Q000009:adverse effects; D013752:Tetracycline / Q000009:adverse effects
chemical_list: D010406:Penicillins; D013424:Sulfanilamides; D013752:Tetracycline; D004205:Cromolyn Sodium
vernacular_title: Porazheniia legkikh lekarstvennogo geneza, protakaiushchie s giperéozinofilieĭ krovi.