A new synthetic functionalized antigen carrier.
A new synthetic functionalized antigen carrier is described. It consists of a core of seven branched lysine residues, of which each of the four N-terminal lysine residues contains two N-(S-acetylmercaptoacetyl)-glutamyl residues. After removal of the protecting S-acetyl groups affording eight thiol functions, the carrier can easily be conjugated to a properly functionalized antigen, e.g. an S-(Npys)-cysteinyl peptide, thus affording a high molecular weight conjugate with an unusually high antigen content.
Drijfhout
J W
JW
Department of Medical Microbiology, State University, Groningen, The Netherlands.
Bloemhoff
W
W
D000595:Amino Acid Sequence; D000941:Antigens; D002352:Carrier Proteins / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology; D008239:Lysine; D008969:Molecular Sequence Data; D015394:Molecular Structure
D000941:Antigens; D002352:Carrier Proteins; D008239:Lysine