A search for strain differences in response of mice to mutagenesis by thio-TEPA.
After treatment of mice with thio-TEPA Malashenko and colleagues found differences among inbred strains in yield of dominant lethals and of chromosome aberrations in bone marrow, which they attributed to genes affecting repair. An attempt was made to confirm this work by comparing yields of dominant lethals in different strains of females mated to the same strain of males. However, no differences were found, all strain combinations giving 42-49% dominant lethals after a dose of 2 mg/kg thio-TEPA to late spermatids. Thus, the existence of genetic differences in repair of thio-TEPA induced lesions between strains CBA and C57BL/6J and between C3H/He and 101/H is not confirmed. Possible reasons for the discrepant results are discussed.
Lyon
M F
MF
MRC Radiobiology Unit, Chilton, Didcot, Oxon, Great Britain.
Glenister
P H
PH
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D005799:Genes, Dominant; D005804:Genes, Lethal; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics; D008810:Mice, Inbred C57BL / Q000235:genetics; D008808:Mice, Inbred CBA / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics*; D016296:Mutagenesis; D009152:Mutagenicity Tests; D013045:Species Specificity; D013087:Spermatids / Q000187:drug effects*; D013852:Thiotepa / Q000633:toxicity*
D013852:Thiotepa