title: Cardiac tamponade early after thrombolysis for acute myocardial infarction: a rare but not reported hemorrhagic complication.
abstract: Among 392 consecutive patients admitted for acute myocardial infarction and treated with thrombolytic drugs, 4 patients (1%) developed an early hemorrhagic pericardial effusion (without ventricular wall rupture) evolving within 24 h to cardiogenic shock consequent to cardiac tamponade. They all suffered from a large anterior myocardial infarction treated within 4 h after onset of symptoms with intravenous anisoylated plasminogen streptokinase activator complex (one case), recombinant tissue-type plasminogen activator (rt-PA) (two cases) or streptokinase (one case), anticoagulation with heparin (all cases) and aspirin (three cases). As soon as pericardial effusion was established by echocardiography, emergency percutaneous pericardiocentesis was performed at the bedside 20 +/- 6 h after thrombolytic therapy was started. This corrected immediately the clinical and hemodynamic status of each patient and a catheter was left in the pericardial space for 34 +/- 18 h. Thus, in the presence of unexplained clinical and hemodynamic deterioration occurring during the first 24 h after thrombolytic treatment of a large myocardial infarction, cardiac tamponade should be suspected. Immediate percutaneous pericardiocentesis followed by continuous drainage is a simple and definitive treatment for this complication.
authors.affiliation: Intensive Care Department, University of Louvain Medical School, Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Renkin
authors.forename: B
authors.initials: B
authors.lastname: de Bruyne
authors.forename: E
authors.initials: E
authors.lastname: Benit
authors.forename: J M
authors.initials: JM
authors.lastname: Joris
authors.forename: M
authors.initials: M
authors.lastname: Carlier
authors.forename: J
authors.initials: J
authors.lastname: Col
mesh_terms: D000368:Aged; D016255:Anistreplase / Q000009:adverse effects; D002305:Cardiac Tamponade / Q000139:chemically induced*; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D010490:Pericardial Effusion / Q000139:chemically induced*; D013300:Streptokinase / Q000009:adverse effects; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000009:adverse effects
chemical_list: D005343:Fibrinolytic Agents; D016255:Anistreplase; D013300:Streptokinase; D010959:Tissue Plasminogen Activator