[Relation between the DNA content in laryngeal cancer cell and its clinical behaviour].
The DNA contents of 45 cases of laryngeal cancer have been analyzed by flow cytometry (FCM). The DNA index (DI) ranged from 0.9 to 3.39; proliferative index (PI) was 27.3%. Among them, 13 cases (28.8%) were diploid and 31 (68.8%) distinctly aneuploid. Correlation has been found between DI and the histopathologic grades of the tumors. The larger the DI, the higher the histopathologic grade (P less than 0.05). The mean value of the PI in supraglottic types was higher than that of glottic types. DNA content analysis also showed that diploid tumor had a better prognosis and longer survival than those with higher DI values. In addition, the proliferative activity of cancer cell was found to be markedly reduced after irradiation which demonstrates that preoperative radiotherapy is favourable for laryngeal cancer.
Zhou
W
W
Hebei Provincial Cancer Hospital, Shijiazhuang.
D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005434:Flow Cytometry; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis
D004273:DNA, Neoplasm