[Studies on flomoxef in the perinatal period].
Pharmacokinetic, bacteriological and clinical studies on flomoxef (FMOX) in the perinatal period were carried out with the following summary of the results. Antibacterial effects of FMOX on the growth of methicillin-resistant Staphylococcus aureus (MRSA, MIC 400 micrograms/ml), methicillin-sensitive S. aureus (MSSA, MIC 0.78 microgram/ml), Escherichia coli (MIC 3.13 micrograms/ml and MIC 0.20 microgram/ml) in amniotic fluid were determined and it was found that the activity of FMOX was enhanced in the amniotic fluid. FMOX rapidly penetrated into tissues and sera of pregnant women upon intravenous injection and its maternal serum concentrations reached their peak levels shortly after administration. Placental penetration of FMOX to the fetus was good and, after single intravenous injection of 1 g, the concentrations of FMOX in the umbilical cord serum and amniotic fluid exceeded MICs against major causative organisms of perinatal infections. These results indicate that single intravenous injection of FMOX 1 g twice a day is effective for the treatment and prophylaxis of perinatal infections. Injection of FMOX for the treatment of 14 cases of puerperal infections showed excellent clinical effectiveness with 100% clinical effect and 81.8% bacteriological response. No side-effect was observed in any case. All of these results suggested clinical usefulness of FMOX in the perinatal period.
Cho
N
N
Department of Obstetrics and Gynecology, Showa University, Fujigaoka Hospital.
Fukunaga
K
K
Kunii
K
K
Kobayashi
I
I
D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism / Q000382:microbiology; D002511:Cephalosporins / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D002821:Chorioamnionitis / Q000188:drug therapy; D004352:Drug Resistance, Microbial; D004716:Endometritis / Q000188:drug therapy; D004926:Escherichia coli / Q000187:drug effects*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005334:Fever / Q000188:drug therapy; D006801:Humans; D008413:Mastitis / Q000188:drug therapy; D016106:Methicillin Resistance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011645:Puerperal Infection / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects*
D002511:Cephalosporins; C045693:flomoxef