Intramitochondrial formation of oxidized glutathione during the oxidation of benzylamine by monoamine oxidase.
Oxidation of benzylamine by MAO results in an accumulation of GSSG in mouse liver mitochondria. Formation of GSSG is prevented by deprenyl, an inhibitor of MAO-B, but not by catalase. GSSG accumulation also occurs with dopamine as substrate. Oxidation of monoamines by mitochondrial MAO represents a potential oxidant stress for mitochondria.
Werner
P
P
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029.
Cohen
G
G
D000818:Animals; D001596:Benzylamines / Q000378:metabolism*; D003010:Clorgyline / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism*; D012642:Selegiline / Q000494:pharmacology; D013379:Substrate Specificity
D001596:Benzylamines; D012642:Selegiline; C030796:benzylamine; D006861:Hydrogen Peroxide; D008995:Monoamine Oxidase; D005978:Glutathione; D003010:Clorgyline