title: Central nervous system reactions to cervical myelography.
abstract: In a double blind prospective study of side effects to cervical myelography 38 patients were evaluated with neurologic examination, electroencephalography (EEG), brainstem evoked response (BER), somatosensory evoked responses (SSER), and continuous reaction times prior to and at 6 h and 24 h after myelography with either metrizamide or iohexol. A difference in the incidence of side effects (for example headache, dizziness, nausea, and neck pain) to the two different contrast media indicated that the inconveniences related to myelography were not only due to the spinal puncture. A contrast medium effect on the central nervous system varying from one agent to another was present. A high frequency of EEG deteriorations among patients with adverse clinical reactions and on only discrete affection upon BER indicated the reaction to be located to the cerebral cortex. Weakened tendon reflexes and reduced strength in the upper extremities were probably caused by blockade in the motor roots as SSER were normal indicating no affection of the sensory pathways. This hypothesis is in agreement with the fact that the patients were in the prone position in the first phase of the investigation causing the highest concentration of contrast medium around the motor roots and the anterior part of the spinal cord. Difference in metabolic effect may explain differences in side effects of metrizamide and iohexol.
authors.affiliation: Department of Diagnostic Radiology, Hvidovre Hospital, University of Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Vestergaard
authors.forename: K
authors.initials: K
authors.lastname: Dons
authors.forename: V
authors.initials: V
authors.lastname: Eskesen
authors.forename: C
authors.initials: C
authors.lastname: Kruse-Larsen
authors.forename: B B
authors.initials: BB
authors.lastname: Lyon
authors.forename: P A
authors.initials: PA
authors.lastname: Søborg
authors.forename: N O
authors.initials: NO
authors.lastname: Jensen
authors.forename: J
authors.initials: J
authors.lastname: Praestholm
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002490:Central Nervous System / Q000187:drug effects*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D005260:Female; D006801:Humans; D007472:Iohexol / Q000009:adverse effects; D008297:Male; D008793:Metrizamide / Q000009:adverse effects; D008875:Middle Aged; D009192:Myelography / Q000009:adverse effects*; D009333:Neck; D011446:Prospective Studies; D011930:Reaction Time / Q000187:drug effects
chemical_list: D007472:Iohexol; D008793:Metrizamide