GTP-dependent membrane fusion during hepatocarcinogenesis and liver regeneration.
Rough microsomes were isolated from homogenates of livers of rats bearing hepatomas as well as from homogenates of livers of rats 24 and 48 h after partial hepatectomy. When incubated in the presence of GTP in a cell-free system to assay membrane fusion these membranes were observed to have a greater capacity (1.4 to 5 fold) for GTP-dependent fusion than homologous membranes from control non-proliferating liver tissue. The enhanced GTP-dependent membrane fusion may reflect changes in membrane properties related to cell proliferation.
Paiement
J
J
Département d'anatomie, Faculté de médecine, Université de Montréal, Québec, Canada.
Dominguez
J M
JM
Guénette
A
A
Roy
L
L
D016604:Aflatoxin B1; D000348:Aflatoxins; D000818:Animals; D002273:Carcinogens; D002455:Cell Division / Q000187:drug effects; D004261:DNA Replication; D006160:Guanosine Triphosphate / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D008099:Liver / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D008115:Liver Regeneration; D008297:Male; D008561:Membrane Fusion / Q000187:drug effects*; D008854:Microscopy, Electron; D008862:Microsomes, Liver / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D011916:Rats, Inbred F344
D000348:Aflatoxins; D002273:Carcinogens; D006160:Guanosine Triphosphate; D016604:Aflatoxin B1