[Experimental research on the safety of the new gestagen preparation acetomepregenol].
In the experiments on mature females of 50 rats, 10 rabbits, 8 dogs it was established that a new gestagenic drug acetomepregenol was not toxic both for pregnant and nonpregnant animals. The two-month administration of the drug in the therapeutic and maximal doses did not exert the irreversible effects on the reproductive function and did not influence the embryonal and postnatal development of the offspring. A single administration of acetomepregenol in the critical periods of pregnancy was found to exert the embryotoxic effect which did not manifest itself during daily administration of the drug from the 6th through the 16th days of pregnancy.
Nikitina
G V
GV
D000818:Animals; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology* / Q000633:toxicity; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D011244:Pregnadienediols / Q000494:pharmacology* / Q000633:toxicity; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens; D013997:Time Factors
D003277:Contraceptives, Oral, Combined; D011244:Pregnadienediols; D013723:Teratogens; C027475:mepregenol diacetate
Eksperimental'noe issledovanie bezvrednosti novogo gestagennogo preparata atsetomepregenola.