[The value of placental histology for the detection of genetically-induced abortions].
The majority of early spontaneous abortions is caused by genetic disorders. Chromosomal aberrations do not only imply characteristical morphologic alterations in embryo/fetus, but also in chorionic villi. Its possible to draw conclusions through the combination of a small amount of histological findings on chorionic villi to explain the kind of aneuploidy. Among 968 early spontaneous abortions 18.3% were defined as genetically caused by histological examination. 87.6% are probably trisomies, 7.3% polyploidies. 5.1% were diagnosed as complete hydatidiform moles with a diploid, androgenetic chromosome set. The value of histological examination of early spontaneous abortion tissue are discussed and it is pointed out to remaining problems. In a different percentage it is possible to establish the type of aneuploid by microscopic examination alone. Frequently there are sings to allow the conclusion there is a developmental disorder like genetic aberration.
Horn
L C
LC
Institut für Pathologische Anatomie des Bereiches Medizin, Karl-Marx-Universität Leipzig.
Rosenkranz
M
M
Bilek
K
K
D000027:Abortion, Incomplete / Q000235:genetics / Q000473:pathology; D000030:Abortion, Missed / Q000235:genetics / Q000473:pathology; D000022:Abortion, Spontaneous / Q000235:genetics* / Q000473:pathology; D000328:Adult; D002824:Chorionic Villi / Q000473:pathology; D015193:Chorionic Villi Sampling; D002869:Chromosome Aberrations / Q000235:genetics* / Q000473:pathology; D025063:Chromosome Disorders; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics / Q000473:pathology; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology
Wertigkeit der Plazentahistologie für die Erkennung genetisch bedingter Aborte.