Interferon-gamma enhances PAF-acether production by stimulated human polymorphonuclear leucocytes.
Human polymorphonuclear leucocytes (PMN) stimulated with either immune complexes (IC), phorbol myristate acetate (PMA) or N-formyl-methionyl-leucyl-phenylalanine (FMLP) generate platelet-activating factor (PAF-acether). The present study demonstrates that treatment of PMN with recombinant human interferon-gamma (IFN-gamma) significantly enhanced the production of PAF-acether by stimulated cells, in a concentration-dependent mode. On the contrary, alpha and beta IFN were completely unable to increase PAF-acether synthesis by stimulated PMN. The significance of these results is discussed.
Geffner
J R
JR
Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
Schattner
M A
MA
Lazzari
M A
MA
Isturiz
M A
MA
D000936:Antigen-Antibody Complex / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000096:biosynthesis*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000936:Antigen-Antibody Complex; D010972:Platelet Activating Factor; D009240:N-Formylmethionine Leucyl-Phenylalanine; D007371:Interferon-gamma; D013755:Tetradecanoylphorbol Acetate