Adipose-tissue fatty acid composition in recipients of long-term total parenteral nutrition (TPN).
Adipose-tissue fatty acid composition was studied in nine patients requiring long-term total parenteral nutrition (TPN). The patients received 17 +/- 8% of total energy as soybean-oil emulsion (Intralipid) and 66 +/- 8% as glucose. Despite low intake of 9c-16:1, 11c-18:1, and 13c-18:1, adipose-tissue concentrations of these monounsaturated fatty acids were higher in the TPN patients than in free-living control subjects (P less than 0.05) and inversely correlated with the percent energy from fat (r = -0.56, P = 0.11; r = -0.64, P = 0.06; r = -0.81, P = 0.008, respectively). This suggests that these fatty acids accumulated from endogenous synthesis from carbohydrate and thus may be markers of the percent fat in the diet. The essential fatty acids, 18:2 and 18:3n-3, positively correlated with the percent energy from fat (r = 0.79, P = 0.01; r = 0.80, P = 0.01, respectively). Linear-regression analysis suggests that normal adipose-tissue stores of 18:2 and 18:3n-3 are maintained when intravenous soybean-oil emulsion provides 11-20% and 4-12%, respectively, of total energy.
Ito
Y
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Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Hudgins
L C
LC
Hirsch
J
J
Shike
M
M
D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D000368:Aged; D004041:Dietary Fats / Q000008:administration & dosage; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D012044:Regression Analysis; D013024:Soybean Oil / Q000008:administration & dosage
D004041:Dietary Fats; D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids; D013024:Soybean Oil; D005947:Glucose