title: Effect of mouthrinsing after toothbrushing with a fluoride dentifrice on human salivary fluoride levels.
abstract: In a recent clinical trial of sodium monofluorophosphate dentifrices, oral rinsing habits were found to influence dental caries. Thus an oral fluoride clearance study has been undertaken which was designed to test a possible mechanism for the observed effects. Eight subjects brushed with one of the trial dentifrices and then rinsed using 1 of 8 procedures of varying thoroughness. The salivary fluoride concentration measured 5 min after dentifrice application decreased significantly with increasing rinse volume, rinse duration, and rinse frequency (p less than 0.01, analysis of variance). The area under the clearance curve determined over a further 3 h was significantly higher (300%; p less than 0.01) following use of the least thorough rinsing procedure (5 ml x 2 s once) as compared with the corresponding area under the clearance curve following the most thorough procedure (20 ml x 10 s twice). These findings indicate that rinsing habits may play an important role in the oral retention of fluoride from dentifrices which may, in turn, affect their clinical efficacy.
authors.affiliation: Unilever Dental Research, Port Sunlight Laboratory, Bebington, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Duckworth
authors.forename: D T
authors.initials: DT
authors.lastname: Knoop
authors.forename: K W
authors.initials: KW
authors.lastname: Stephen
mesh_terms: D000328:Adult; D003731:Dental Caries / Q000517:prevention & control; D003802:Dentifrices / Q000627:therapeutic use*; D005459:Fluorides / Q000032:analysis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D009067:Mouthwashes / Q000008:administration & dosage / Q000494:pharmacology*; D010710:Phosphates / Q000627:therapeutic use; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D013997:Time Factors; D014099:Toothbrushing; D014867:Water
chemical_list: D003802:Dentifrices; D009067:Mouthwashes; D010710:Phosphates; D014867:Water; C012980:fluorophosphate; D005459:Fluorides