title: Large vessel occlusion with vasculitis in systemic lupus erythematosus.
abstract: Patients with SLE may have acute large vessel occlusion due to vasculitis and/or circulating antiphospholipid antibodies, as illustrated by the case we have reported. Unfortunately, delayed medical attention led to gangrene of the foot and amputation. Early recognition and appropriate treatment may significantly decrease morbidity and mortality. Medical treatment may include corticosteroids, thrombolysis, anticoagulation, or immunosuppression.
authors.affiliation: Department of Medicine, University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City 73190.
authors.forename: S M
authors.initials: SM
authors.lastname: Harmon
authors.forename: K L
authors.initials: KL
authors.lastname: Oltmanns
authors.forename: K W
authors.initials: KW
authors.lastname: Min
mesh_terms: D000328:Adult; D000671:Amputation, Surgical; D001158:Arteries; D001167:Arteritis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D013977:Tibia / Q000098:blood supply*; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
chemical_list: D014568:Urokinase-Type Plasminogen Activator