title: [Modeling of the semi-circular canal, application to labyrinthine hydrops].
abstract: The angular accelerometer of vertebrates, the semi circular canal, is a pressure gage. The transformation, acceleration to pressure, is due to the inertia of the endolymph. In the 0 to 1 Hz frequency interval, the endolymph-cupula system can be described by a second order, localised parameter model with two real time constants. This mechanical model explains the occurr]nces of the vestibular-ocular reflex during rotatory stimulations. However, some features of the response to caloric stimulations cannot be explained from this unique point of view. To correspond to these features, the SCC has to be considered as an inflatable structure, sensitive to weak pressure variations between the endolymph and perilymph. Different parameters of the mechanical model, the internal radius of the membranous canal, the dimension of the cupula and its elasticity coefficient depend on the inflating pressure. Ménière's disease is caracterised by hydrops, i.e. an increase of the pressure in the membranous SCC. The different mechanisms related to this hydrops, in particular introducing the inflating pressure as a second input to the ampular system, associated to a new concept of the mechanoneural transduction can explain the classical vestibular symptoms of Ménière's disease. Therefore, this overall mechanical model of the SCC indicates that hydrops is the mechanical cause of Ménière's disease and the primary cause is more likely to be a defect in the regulation loop of the inflating pressure.
authors.affiliation: Institut de Mécanique des Fluides URA CNRS 854, Université Louis Pasteur, Strasbourg.
authors.forename: C
authors.initials: C
authors.lastname: Kopp
authors.forename: E
authors.initials: E
authors.lastname: Njeugna
authors.forename: J L
authors.initials: JL
authors.lastname: Eichhorn
authors.forename: A
authors.initials: A
authors.lastname: Gentine
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D004487:Edema; D006801:Humans; D007759:Labyrinth Diseases; D008575:Meniere Disease; D008954:Models, Biological; D012665:Semicircular Canals / Q000503:physiopathology*
vernacular_title: Modélisation du canal semi-circulaire, application à l'hydrops labyrinthique.