Growth after renal transplantation: an update.
Several factors influencing post-transplant growth were analysed in a total of 163 children receiving transplants at the Medical School Hannover. Statural height at the time of transplantation depended on the length of the pre-transplant period of chronic renal failure, and was more retarded in children with congenital renal diseases than in those with acquired diseases. The retardation of bone age correlated significantly with the degree of growth retardation. The immunosuppressive regimen of cyclosporine A (CyA) and low-dose prednisolone was followed by significantly better growth rates than azathioprine (Aza) plus high-dose prednisolone. In 22 prepubertal children receiving CyA, poor graft function with a glomerular filtration rate below 40 ml/min per 1.73 m2 inhibited catch-up growth. The final height of 20 grown-up transplant recipients was found to be in the lower range of normal. A comparison of conventional and CyA treatment showed that adult height in the CyA group was higher than in the Aza group due to a significantly higher growth velocity.
Offner
G
G
Kinderklinik, Medizinische Hochschule Hannover, Federal Republic of Germany.
Aschendorff
C
C
Brodehl
J
J
D000293:Adolescent; D001379:Azathioprine / Q000627:therapeutic use; D001827:Body Height; D001846:Bone Development / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006085:Graft Survival / Q000502:physiology; D006130:Growth Disorders / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012189:Retrospective Studies
D016572:Cyclosporine; D011239:Prednisolone; D001379:Azathioprine