A variant translocation t(2;18) in follicular lymphoma involves the 5' end of bcl-2 and Ig kappa light chain gene.
We have examined three cases of human lymphoma bearing a t(2;18)(p11;q21) chromosome translocation. The bcl-2 gene appeared to be rearranged in all three cases and breakpoints were clustered in the 5' flanking region of the gene. In all three cases, bcl-2 was juxtaposed to J segments of the Ig kappa gene. This juxtaposition of the bcl-2 and Ig kappa genes is very similar to the variant chromosome translocations of Burkitt lymphoma that juxtapose the c-myc locus to IgL genes.
Hillion
J
J
Unité 301-INSERM and SDI no. 15954 I CNRS, Institut de Génétique Moléculaire, Paris, France.
Mecucci
C
C
Aventin
A
A
Leroux
D
D
Wlodarska
I
I
Van Den Berghe
H
H
Larsen
C J
CJ
D000328:Adult; D015139:Blotting, Southern; D002887:Chromosomes, Human, Pair 18; D002889:Chromosomes, Human, Pair 2; D015342:DNA Probes; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008224:Lymphoma, Follicular / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2; D014178:Translocation, Genetic
D015342:DNA Probes; D007145:Immunoglobulin kappa-Chains; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2