Role of Ca2+/H+ antiporter in the kidney.
Three different mechanisms for H+ transport mediated by Ca2+ have been reported. First is an ATP-dependent Ca2+/H+ antiporter which is catalyzed by (Ca2+ + Mg2+)-ATPase in plasma membrane. Second is a compensatory Ca2+ movement associated with an ATP-dependent H+ pump catalyzed by H(+)-ATPase in endosome. Third is a mitochondrial Ca2+ movement driven by an electrophoretic H+ driving force. All these processes must play a critical role on transfering messages between Ca2+ and H+. Data indicate that an ATP-dependent Ca2+ pump is an electroneutral Ca2+/H+ antiporter in renal tubular cells as well as in other nonrenal cells. The existence of this process is compatible with the physiological phenomena of Ca2+ and H+ transport in renal tubules, although we still lack direct evidence to comprehend the role of the Ca2+/H+ pump in the kidney.
Tsukamoto
Y
Y
Department of Medicine, Kitasato University School of Medicine, Kanagawa, Japan.
Sugimura
K
K
Suki
W N
WN
D000143:Acids / Q000652:urine; D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007684:Kidney Tubules / Q000166:cytology / Q000378:metabolism
D000143:Acids; D002352:Carrier Proteins; D006859:Hydrogen; D000255:Adenosine Triphosphate; D002118:Calcium