title: Inhibition by vitamin D3 of erythroid differentiation of human leukemia line cells induced by transforming growth factor beta or erythroid differentiation factor (activin A).
abstract: Erythroid differentiation of human leukemic cell lines (HEL, KU812F and K562) was induced by their treatment with transforming growth factor beta (TGF-beta) or erythroid differentiation factor (EDF/Activin A). Their erythroid differentiation was markedly inhibited by vitamin D3, dexamethasone or 12-O-tetradecanoyl-phorbol-13-acetate, which are known to induce monocytic differentiation of leukemic cells. These results suggest that inducers of monocytic differentiation may switch off cellular regulatory mechanisms for induction by TGF-beta and EDF of erythroid differentiation of leukemia cells.
authors.affiliation: Department of Chemotherapy, Saitama Cancer Center Research Institute, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Okabe-Kado
authors.forename: Y
authors.initials: Y
authors.lastname: Honma
authors.forename: M
authors.initials: M
authors.lastname: Hozumi
mesh_terms: D028341:Activins; D002117:Calcitriol / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D015672:Erythroid Precursor Cells / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D007265:Inhibins / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000473:pathology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D016212:Transforming Growth Factor beta; D028341:Activins; D007265:Inhibins; D003907:Dexamethasone; D002117:Calcitriol; D013755:Tetradecanoylphorbol Acetate