title: Ribose facilitates thallium-201 redistribution in patients with coronary artery disease.
abstract: To investigate whether i.v. infusion of ribose, an adenine nucleotide precursor, postischemia facilitates thallium-201 (201Tl) redistribution and improves identification of ischemic myocardium in patients with coronary artery disease (CAD), 17 patients underwent two exercise 201Tl stress tests, performed 1-2 wk apart. After immediate postexercise planar imaging, patients received either i.v. ribose (3.3 mg/kg/min x 30 min) or saline as a control. Additional imaging was performed 1 and 4 hr postexercise. Reversible defects were identified by count-profile analysis. Significantly more (nearly twice as many) reversible 201Tl defects were identified on the post-ribose images compared to the post-saline (control) images at both 1 and 4 hr postexercise (p less than 0.001). Quantitative analyses of the coronary arteriogram was available in 13 patients and confirmed that the additional reversible defects were in myocardial regions supplied by stenosed arteries. We conclude that ribose appears to facilitate 201Tl redistribution in patients with CAD and enhances identification of ischemic myocardium.
authors.affiliation: Div. of Cardiology, Oregon Health Sciences Univ., Portland 97201-3098.
authors.forename: N S
authors.initials: NS
authors.lastname: Perlmutter
authors.forename: R A
authors.initials: RA
authors.lastname: Wilson
authors.forename: D A
authors.initials: DA
authors.lastname: Angello
authors.forename: R T
authors.initials: RT
authors.lastname: Palac
authors.forename: J
authors.initials: J
authors.lastname: Lin
authors.forename: B G
authors.initials: BG
authors.lastname: Brown
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005080:Exercise Test; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012266:Ribose / Q000008:administration & dosage; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics
chemical_list: D013794:Thallium Radioisotopes; D012266:Ribose