title: Solid and cystic pancreatic tumors. Clinical, histochemical, and electron microscopic features in ten cases.
abstract: Ten cases of the rare solid and cystic pancreatic tumors are presented. All except one occurred in young women (mean age, 25 +/- 9.2 years). The large neoplasms were evenly distributed across the pancreas; in one case, metastasis occurred; all other cases were free from disease after complete resection. Histologic hallmarks of solid and cystic neoplasms were papillary growth, large intracytoplasmic granules, and immunoreactivity with alpha 1-antitrypsin, alpha 1-antichymotrypsin, phospholipase A2, and neuroendocrine markers (neuron-specific enolase [NSE], synaptophysin). This suggests both endocrine as well as exocrine differentiation.
authors.affiliation: Institute of Pathology, University of Erlangen Nürnberg, West Germany.
authors.forename: P
authors.initials: P
authors.lastname: Stömmer
authors.forename: J
authors.initials: J
authors.lastname: Kraus
authors.forename: M
authors.initials: M
authors.lastname: Stolte
authors.forename: J
authors.initials: J
authors.lastname: Giedl
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000032:analysis; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000032:analysis; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D010741:Phospholipases A / Q000032:analysis; D054467:Phospholipases A2; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D016708:Synaptophysin
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D009418:S100 Proteins; D016708:Synaptophysin; D010741:Phospholipases A; D054467:Phospholipases A2; D010751:Phosphopyruvate Hydratase