Accuracy of intraoperative ultrasonography in diagnosing liver metastasis from colorectal cancer: evaluation with postoperative follow-up results.
The accuracy of intraoperative ultrasonography in diagnosing liver metastasis was evaluated at the time of surgery and at follow-up in 189 patients with colorectal cancers. Evaluation at the time of operation revealed that the sensitivity of intraoperative ultrasonography (93.3%) was significantly (p less than 0.0001) higher than that of preoperative ultrasonography (41.3%), conventional computed tomography (47.1%), and surgical exploration (66.3%). Twenty-two of 104 metastatic liver tumors were detected solely by intraoperative ultrasonography in 18 patients (9.5% of total patients). These 22 tumors were small in size (4 x 4 mm to 15 x 18 mm) and nonpalpable during operation. During the postoperative follow-up period of 18 months or more (mean 35.6 months, median 37.1 months) after colorectal surgery, liver metastases that were unrecognized during surgery appeared in 13 (6.9%) patients. Re-evaluation based on these follow-up results indicated that the sensitivity of intraoperative ultrasonography decreased to 82.3%, which was still significantly (p less than 0.0005) better than that of other methods. Intraoperative ultrasonography was capable of identifying 18 of 31 (58.1%) patients in whom liver metastases were otherwise unrecognized at the time of operation. Intraoperative ultrasonography is more accurate in diagnosing liver metastasis than traditional screening methods, and may have a beneficial impact on the management of colorectal cancer.
Machi
J
J
First Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan.
Isomoto
H
H
Kurohiji
T
T
Yamashita
Y
Y
Shirouzu
K
K
Kakegawa
T
T
Sigel
B
B
Zaren
H A
HA
Sariego
J
J
D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007432:Intraoperative Period; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014463:Ultrasonography