HTLV-I neurotropism. In vitro studies.
The human T cell leukemia lymphoma virus (HTLV-I) has been recently associated to neurological disorders. In order to investigate the interaction between this virus and the central nervous system, cells of neuroectodermic origin have been exposed to HTLV-I through an experimental in vitro model. The results revealed the presence of HTLV-I virus core protein p19 inside glial cells, after a short time exposure to a chronically infected donor cell line. This suggests a possible role of a lymphotropic retrovirus in neurological diseases.
Macchi
B
B
Department of Experimental Medicine and Biochemical Science, University of Rome, Italy.
Caronti
B
B
Gremo
F
F
Torelli
S
S
Bonmassar
E
E
Lauro
G M
GM
D000818:Animals; D015490:HTLV-I Infections / Q000503:physiopathology*; D006801:Humans; D009422:Nervous System Diseases / Q000382:microbiology / Q000503:physiopathology*