Establishment of chronic intravenous drug self-administration in the C57BL/6J mouse.
A wide variety of drugs that have significant human abuse potential have been demonstrated to function as positive reinforcers in animals. The present study was designed to characterize a new mouse model of chronic intravenous drug self-administration. Adult male C57BL/6J mice, implanted with external jugular infusion catheters, were given access to response-contingent injections. They did not initiate responding for saline delivery, whereas the C57BL/6J mice initiated morphine, cocaine, methamphetamine and pentobarbital self-administration. Drug-maintained responding was consistently and significantly higher for each compound than for saline responding. In contrast to C57BL/6J mice, DBA/2J mice failed to initiate cocaine self-administration. Thus, chronic intravenous drug self-administration procedures can be adapted to the inbred mouse.
Carney
J M
JM
Department of Pharmacology, Chandler Medical Center, University of Kentucky, Lexington.
Landrum
R W
RW
Cheng
M S
MS
Seale
T W
TW
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage*; D004195:Disease Models, Animal; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009020:Morphine / Q000008:administration & dosage*; D010424:Pentobarbital / Q000008:administration & dosage*; D012646:Self Administration; D013045:Species Specificity; D019966:Substance-Related Disorders
D008694:Methamphetamine; D009020:Morphine; D010424:Pentobarbital; D003042:Cocaine