title: Growth hormone regulation by growth hormone-releasing hormone in infant rhesus monkeys.
abstract: To study the relationship of endogenous GHRH to the changes seen in serum GH concentration in neonatal primates, we administered antiserum to GHRH (GHRH-Ab) or GHRH antagonist, (N-Acetyl-Tyr1,D-Arg2)GHRH-(1-29)-NH2, to unanesthetized, fasted rhesus monkeys, 1-31 days of age, via an acutely placed venous catheter. The administration of GHRH-Ab resulted in a significant decrease in serum GH concentration at 1-2 and 7-9 days, but not at 28-31 days of age. The administration of GHRH antagonist resulted in a significant decrease in serum GH concentrations at 1-2 days, but not at 7 or 14 days of age. These results imply that basal serum GH is more dependent on endogenous GHRH at 1-2 days than after 7-28 days of age. This suggests developmental changes in the hypothalamic regulation of GH secretion with advancing age in the neonatal period.
authors.affiliation: Department of Pediatrics, University of California-Davis, School of Medicine.
authors.forename: M D
authors.initials: MD
authors.lastname: Wheeler
authors.forename: W W
authors.initials: WW
authors.lastname: Wehrenberg
authors.forename: D M
authors.initials: DM
authors.lastname: Styne
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D008253:Macaca mulatta; D010446:Peptide Fragments / Q000494:pharmacology; D017337:Sermorelin / Q000031:analogs & derivatives*
chemical_list: D010446:Peptide Fragments; D017337:Sermorelin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; C058677:somatotropin releasing hormone (1-29)amide, N-acetyl-tyrosyl(1)-arginyl(2)-