[Invasion of human lung adenocarcinoma cell line LTEP-a2 into various organs of different species].
The invasiveness of human lung adenocarcinoma cell line LTEP-a2 was investigated in co-culture system of tumor cells and fragments of the heart and liver from the newborn, rabbit and rat. It was found that the tumor cells had different invasive behaviors, for example cell diastrophism, proliferation or invasion speed and adenic formation when invading various species or various organs in the same species. When invading the fragments of newborn heart and liver, strong cell diastrophism potential, cell twist or formation of multiprocess pseudopodia and mitosis could be observed. The result was contrary to the above when the fragments of rat heart and liver were used as the target. When the fragments of rabbit liver were invaded, marked adenization was formed by cancer cells with the invading speed increased. However, the adenic structure was absent as the heart fragments of rabbit were invaded. The results indicate that target organs could change biological behavior of the invading tumor cells to different degrees even their differentiation. It may be related to structure and biochemical property of the target organs.
He
B
B
Harbin Medical College.
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D006801:Humans; D008099:Liver / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology*; D009206:Myocardium / Q000473:pathology; D009361:Neoplasm Invasiveness; D009924:Organ Culture Techniques; D009928:Organ Specificity; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014407:Tumor Cells, Cultured / Q000473:pathology