Minor histocompatibility antigens.
Histocompatibility antigens have been studied for over 50 years because they form a major obstacle to clinical transplantation. Human minor histocompatibility antigens remain ill-defined, but minor histocompatibility loci have been mapped on nearly every mouse chromosome. Recent molecular definition of several transplantation antigens suggests that they are by-products of an immune system poised to present viral antigens, and a mutation in any gene may give rise to a new minor histocompatibility antigen.
Lindahl
K F
KF
Howard Hughes Medical Institute, Department of Microbiology, University of Texas, Southwestern Medical Center, Dallas 75235-9050.
D000595:Amino Acid Sequence; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D008969:Molecular Sequence Data; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology
D015778:Minor Histocompatibility Antigens