title: Non-lymphoid blast crisis of CML with rearrangement of immunoglobulin and T-cell receptor delta genes.
abstract: We report a patient with chronic myeloid leukaemia (Philadelphia-positive with M-BCR rearrangement) in transformation whose blast cells had myelomonocytic morphology, absent terminal deoxynucleotidyl transferase expression and non-lymphoid cell surface markers (CD10-, CD19-, CD33+, CD14+, CD11+). Leukaemia cell DNA showed rearrangement of both immunoglobulin heavy chain and T-cell receptor delta genes. Such rearrangements may be a feature of a small proportion of patients with non-lymphoid transformation of CML as they are in a minority of cases of de novo acute non-lymphoblastic leukaemia.
authors.affiliation: Department of Haematology, Royal Postgraduate Medical School, London, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Bashey
authors.forename: T
authors.initials: T
authors.lastname: Vulliamy
authors.forename: B S
authors.initials: BS
authors.lastname: Cai
authors.forename: A P
authors.initials: AP
authors.lastname: Schwarer
authors.forename: J M
authors.initials: JM
authors.lastname: Goldman
mesh_terms: D000208:Acute Disease; D000328:Adult; D001752:Blast Crisis; D015321:Gene Rearrangement; D015329:Gene Rearrangement, T-Lymphocyte; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007951:Leukemia, Myeloid / Q000235:genetics / Q000473:pathology*; D008297:Male
chemical_list: D007143:Immunoglobulin Heavy Chains