title: Ovarian carcinoma metastatic to the breast and axillary node.
abstract: Breast cancer is a common primary malignancy in women. On rare occasion the breast is also the site of metastatic disease. This report describes the evaluation of breast and axillary masses in a patient with known ovarian cancer, including the radiographic evaluation and special immunohistochemical stains with CA-125. Flow cytometric determinations and hormonal receptor analysis on both the primary and metastatic tumors demonstrate similar biologic characteristics. Both tumor sites demonstrated positive CA-125 staining, aneuploid DNA populations, moderately positive estrogen receptor content, and negative progesterone receptors. The mammogram demonstrated a well-circumscribed lesion with several areas of microcalcifications. Blood-borne metastasis from the ovary to the breast can show a varied clinical picture that can be differentiated from that of a primary breast carcinoma.
authors.affiliation: Department of Surgery, Northwestern University Medical School, Chicago, Ill.
authors.forename: R B
authors.initials: RB
authors.lastname: Duda
authors.forename: C Z
authors.initials: CZ
authors.lastname: August
authors.forename: J C
authors.initials: JC
authors.lastname: Schink
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D001365:Axilla; D001943:Breast Neoplasms / Q000556:secondary*; D003536:Cystadenocarcinoma / Q000473:pathology* / Q000556:secondary; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D004273:DNA, Neoplasm