title: Acute ascending necrotizing myelitis in Okinawa caused by herpes simplex virus type 2.
abstract: A case of rapidly progressing ascending myelitis was necropsied. Necrosis was present throughout the whole length of the spinal cord and involved both the grey and white matter randomly. The perivascular lymphocytic infiltration in the spinal cord in the present case was more pronounced than that in the previously reported two cases of necrotizing myelopathy associated with malignancy. Using immunoperoxidase staining the presence of herpes simplex virus type 2 (HSV 2) antigen was demonstrated. Electron microscopic examinations revealed large numbers of HSV particles in the spinal cord. HSV 2 may be a common aetiological agent of necrotizing myelopathy and myelitis in Okinawa, an HSV 2 endemic area. In the present case, the necrosis was mainly found in the spinal cord but was also observed, to a very limited extent, in the brain.
authors.affiliation: Department of Pathology, Ryukyu University School of Medicine, Okinawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iwamasa
authors.forename: H
authors.initials: H
authors.lastname: Yoshitake
authors.forename: H
authors.initials: H
authors.lastname: Sakuda
authors.forename: Y
authors.initials: Y
authors.lastname: Kamada
authors.forename: M
authors.initials: M
authors.lastname: Miyazato
authors.forename: Y
authors.initials: Y
authors.lastname: Utsumi
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
mesh_terms: D000208:Acute Disease; D000956:Antigens, Viral / Q000032:analysis; D006561:Herpes Simplex / Q000276:immunology / Q000473:pathology; D006564:Herpesviridae; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009187:Myelitis / Q000382:microbiology* / Q000473:pathology; D009336:Necrosis; D010139:Pacific Islands; D013116:Spinal Cord / Q000473:pathology
chemical_list: D000956:Antigens, Viral