title: Effectiveness of fortnightly tooth brushing with amine fluorides in caries-prone subjects.
abstract: The aim of this study was to assess the caries incidence and plaque accumulation in schoolchildren at caries risk, after brushing the teeth fortnightly with gels containing 0, 0.4% F, 1.25% F as amine fluoride (AmF) or the common amine fluoride toothpaste containing 0.125% F. The study was conducted double blind over an 18-month period, and after 6 months discontinuation of brushing. Only the group that brushed with the 1.25% AmF gel showed a significant decrease in caries development compared to the group that brushed with the 0.125% AmF toothpaste. During the 6-month discontinuation period, the incidence of caries increased in all groups; the differences in caries development between all groups were not significant. Plaque indices were significantly lower in the AmF-treated groups. The highest fluoride concentration in the gel reduced the development of caries to zero, probably due to increased fluoride levels in the oral milieu of caries risk children. In order to maintain a positive effect of fluoride over an extended time period, caries-prone subjects should continue an initiated fluoride programme.
authors.affiliation: Dental Research Unit, Hebrew University, Hadassah School of Dental Medicine, Jerusalem, Israel.
authors.forename: F
authors.initials: F
authors.lastname: Ran
authors.forename: I
authors.initials: I
authors.lastname: Gedalia
authors.forename: M
authors.initials: M
authors.lastname: Fried
authors.forename: P
authors.initials: P
authors.lastname: Hadani
authors.forename: A
authors.initials: A
authors.lastname: Tved
mesh_terms: D000293:Adolescent; D000588:Amines / Q000008:administration & dosage / Q000627:therapeutic use*; D000704:Analysis of Variance; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D003733:Dental Caries Susceptibility / Q000187:drug effects*; D004311:Double-Blind Method; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010919:Placebos; D014099:Toothbrushing; D014100:Toothpastes
chemical_list: D000588:Amines; D010919:Placebos; D014100:Toothpastes; D005459:Fluorides