Homochirality and stereospecific activity: evolutionary aspects.
The problem discussed in this paper is the connection between the unique property of biopolymers (proteins, DNA and RNA), i.e. homochirality, and their main functional property, i.e. self-replication. Our approach is based on an analysis of the conditions for the origination of the mechanism of self-replication of chiral polymers. It is demonstrated that self-replication could originate only on the basis of homochiral structures, possessing stereospecific (enzymatic) activity. It is also shown that complete breaking of the mirror symmetry of the organic medium is required both at the stage of polymeric takeover and at the stage of formation of structures possessing stereospecific activity. This requirement is satisfied only in the framework of the mechanism of spontaneous symmetry breaking i.e. the mechanism of non-equilibrium phase transition from the racemic state of the organic medium to the chirally pure one. The results obtained suggest that homochirality is a necessary condition for the origination of biological specificity and plays a fundamental role in the formation of structures capable of self-replication.
Avetisov
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VV
N.N. Semenov Institute of Chemical Physics, Academy of Sciences, Moscow, USSR.
Goldanskii
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VI
D005075:Biological Evolution; D004798:Enzymes / Q000737:chemistry; D008956:Models, Chemical; D009696:Nucleic Acids / Q000737:chemistry; D000069497:Origin of Life; D011506:Proteins / Q000737:chemistry; D013237:Stereoisomerism
D004798:Enzymes; D009696:Nucleic Acids; D011506:Proteins