title: In vitro ablation of normal and diseased vascular tissue by a fiber-transmitted holmium laser.
abstract: An in vitro study was performed to test the ablative potential of a fiber-transmitted pulsed holmium laser (2.1 microns) applied to normal vascular wall, lipomatous plaques, and calcified plaques. Different fluences per pulse of 42, 80, 205, and 315 J/cm2 were used. Ablation of normal tissue and lipomatous plaques was achieved with all power settings. Effective ablation of calcified plaques, however, occurred only after a minimum fluence of 205 J/cm2, and the effect was significantly less pronounced compared to ablation of soft lesions.
authors.affiliation: Department Diagnostic Radiology, Technical University of Aachen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Vorwerk
authors.forename: G
authors.initials: G
authors.lastname: Zolotas
authors.forename: S
authors.initials: S
authors.lastname: Hessel
authors.forename: G
authors.initials: G
authors.lastname: Adam
authors.forename: F
authors.initials: F
authors.lastname: Wondrazek
authors.forename: R W
authors.initials: RW
authors.lastname: Günther
mesh_terms: D016342:Angioplasty, Laser / Q000295:instrumentation* / Q000379:methods; D001011:Aorta / Q000601:surgery* / Q000648:ultrastructure; D001018:Aortic Diseases / Q000473:pathology / Q000601:surgery*; D001161:Arteriosclerosis / Q000473:pathology / Q000601:surgery*; D002102:Cadaver; D005069:Evaluation Studies as Topic; D005336:Fiber Optic Technology / Q000295:instrumentation; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning