title: [History and new development of screening and evaluation methods of anticancer drugs used in vivo and in vitro].
abstract: Screening methods for the detection of anticancer activity are of crucial importance in order to find solid tumor-specific agents. A review of past screening methods is followed by a description of present methodologies targetted toward the discovery of such agents. Finally, we discuss primary and secondary in vivo evaluation in experimental chemotherapy.
authors.affiliation: Rhône-Poulenc-Rorer, centre de recherches de Vitry-Alfortville, unité de cancérologie, Vitry-sur-Seine, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Bissery
authors.forename: G G
authors.initials: GG
authors.lastname: Chabot
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy; D002986:Clinical Trials as Topic / Q000379:methods / Q000639:trends; D004354:Drug Screening Assays, Antitumor / Q000266:history* / Q000379:methods / Q000639:trends; D049673:History, 20th Century; D006801:Humans; D007938:Leukemia / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Historique et récents développements des méthodes de criblage et d'évaluation des molécules anticancéreuses in vitro et in vivo.