title: [The sensitizing properties of the ballast admixtures in human leukocyte interferon].
abstract: Due to the features of its production technology, human leukocyte interferon (HLI) for intranasal administration is likely to contain ovalbumin (OA). Commercial batches of HLI were tested for the presence of OA responsible for the sensitizing effect of HLI given intranasally. The content of OA in commercial batches of HLI was shown to vary widely and to exceed by far the concentrations having the sensitizing effect. As a result of these studies, the upper limit of OA content was established and the technology of HLI production was modified. These measures permitted production of commercial batches of HLI with OA content not exceeding 0.05 micrograms/ml.
authors.forename: E I
authors.initials: EI
authors.lastname: Nikolaeva
authors.forename: N V
authors.initials: NV
authors.lastname: Vardanian
authors.forename: T A
authors.initials: TA
authors.lastname: Bektimirov
authors.forename: V F
authors.initials: VF
authors.lastname: Popov
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced / Q000276:immunology; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004340:Drug Contamination; D006168:Guinea Pigs; D006801:Humans; D007370:Interferon Type I / Q000032:analysis / Q000276:immunology* / Q000592:standards; D010047:Ovalbumin / Q000032:analysis / Q000276:immunology
chemical_list: D007370:Interferon Type I; D010047:Ovalbumin
vernacular_title: Izuchenie sensibiliziruiushchikh svoĭstv ballastnykh primeseĭ chelovecheskogo leĭkotsitarnogo interferona.