Kidney biopsy findings in cyclosporine-treated patients with insulin-dependent diabetes mellitus.
Renal biopsy specimens of 40 patients with recent-onset insulin-dependent diabetes mellitus treated with cyclosporine (CSA) for 6-29 months were examined. Cyclosporine-associated chronic vascular interstitial toxicity of moderate intensity was found in 10 patients (25%). The most prominent lesions were interstitial fibrosis and tubular atrophy. Arteriolopathy was less pronounced and glomerular damage unremarkable. A significant correlation exists between the extent of tubular atrophy and CSA trough whole blood levels. These data indicate that the development of CSA-associated chronic nephropathy is dose-dependent.
Mihatsch
M J
MJ
Institut für Pathologie, Universität Basel, Switzerland.
Helmchen
U
U
Casanova
P
P
Habib
R
R
Larsen
S
S
Magil
A
A
Noel
L H
LH
Rapola
J
J
Ulrich
J
J
Wallace
A C
AC
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000473:pathology; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000473:pathology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007677:Kidney Function Tests; D008134:Long-Term Care; D008297:Male
D003524:Cyclosporins