Morphology of the endocrine pancreas in cyclosporine-treated glucose-intolerant Wistar rats.
The toxic effect of Cyclosporin A (CS-A) (1.25-50.0 mg/kg body weight) on the endocrine pancreas of Wistar rats was morphologically investigated. The treatment of animals with CS-A doses above 5 mg/kg for 2 weeks resulted in a disturbed glucose tolerance, a reduced B-cell volume density and degranulation, vacuolization and decreased mitotic activity of the B-cells. After withdrawal of the drug the impaired parameters were stepwise normalized, starting with regranulation of pancreatic B-cells, followed by a stimulation of mitotic activity, and increase of B-cell volume density. When continuing the CS-A treatment with doses lower than 5.0 mg/kg for longer periods we observed a decreased body weight gain and reduced pancreatic insulin content.
Lucke
S
S
Central Institute of Diabetes Gerhardt Katsch, Karlsburg, FRG.
Radloff
E
E
Laube
R
R
Hahn
H J
HJ
D000818:Animals; D003524:Cyclosporins / Q000009:adverse effects*; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D007515:Islets of Langerhans / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003524:Cyclosporins; D005947:Glucose