[The 5-fluorouracil content of the pancreas and parapancreatic tissues when it is administered regionally into the tissue of the round ligament of the liver].
In the experiment on 31 dogs there was shown a significant increase of 5-fluorouracil concentrations in the pancreas and parapancreatic tissues with regional methods of its administration in the fat of the round ligament of the liver. A more prolonged preservation of the drug concentrations at the therapeutic level in the blood was observed. The most effective method of the cytostatic therapy is the regional lymphotropic method.
Danilov
K Iu
KIu
Brodinova
N S
NS
Kharitonov
S V
SV
Sorokin
I V
IV
Zaranko
E I
EI
D000818:Animals; D010478:Chemotherapy, Cancer, Regional Perfusion; D004285:Dogs; D005472:Fluorouracil / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D006470:Hemorrhage / Q000378:metabolism; D007272:Injections, Intralymphatic; D007275:Injections, Intravenous; D008022:Ligaments; D008099:Liver; D009336:Necrosis; D010179:Pancreas / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D010182:Pancreatic Diseases / Q000378:metabolism
D005472:Fluorouracil
Soderzhanie 5-ftoruratsila v podzheludochnoĭ zheleze i parapankreaticheskikh tkaniakh pri regionarnykh sposobakh ego vvedeniia v kletchatku krugloĭ sviazki pecheni.