[Mitogenic activity of vasculotropin for peripheral human lymphocytes].
Vasculotropin is a growth factor with a unique specificity for vascular derived endothelial cells. We report that normal human peripheral lymphocytes represent another target for vasculotropin. The mitogenic activity of the medium conditioned by these cells cultured in the presence of Concanavalin A is potentiated by vasculotropin. This effect is exerted more likely through interactions with the soluble mediators rather than through the VAS receptors since VAS binds equally to Concanavalin A stimulated and to unstimulated lymphocytes.
Praloran
V
V
Laboratoire d'Hématologie, Hôtel-Dieu, Nantes.
Mirshahi
S
S
Favard
C
C
Moukadiri
H
H
Plouet
J
J
D003208:Concanavalin A / Q000032:analysis; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008934:Mitogens / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D006133:Growth Substances; D008934:Mitogens; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D016222:Fibroblast Growth Factor 2; D003208:Concanavalin A
Activité mitogène de la vasculotropine pour les lymphocytes périphériques humains.