Anticoagulant treatment does not affect the action of flavone acetic acid in tumour-bearing mice.
Flavone acetic acid (FAA) is a novel antitumour agent that has a profound effect on the vasculature in murine tumour models. Previously we have shown that FAA induces a coagulopathy and thrombocytopaenia in tumour-bearing mice, and the purpose of the present study was to determine the significance of the FAA-induced intravascular coagulation in the antitumour action of FAA. Several anticoagulant agents were tested for their effectiveness in altering ex vivo coagulation of murine plasma; heparin and ancrod were found to be most effective. These agents were administered to tumour-bearing mice prior to FAA and TNF treatment with little effect on the induced regrowth delay. However: the FAA-induced consumption of platelets in tumour-bearing mice was not blocked by anticoagulant treatment. These data suggest that platelet consumption occurs independently of the normal coagulation pathway, and further that fibrin deposition may not be a major factor in the antitumour action of FAA.
Thurston
G
G
CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK.
Smith
K A
KA
Murray
J C
JC
D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010976:Platelet Count / Q000187:drug effects; D011517:Prothrombin Time
D000925:Anticoagulants; D000970:Antineoplastic Agents; D005419:Flavonoids; C049328:flavone acetic acid