title: [Juvenile parkinsonism in monozygotic twins].
abstract: A pair of monozygotic twins concordant for juvenile Parkinsonism are described. These twin sisters have lived together until 18 years old. Twin A noted tremor in the right hand and right-sided stiffness and slowness at the age 20. Initially, a marked improvement was shown with L-dopa treatment. However, one year after the beginning of treatment, dopa-induced dyskinesia appeared. Twin B noted tremor and right-sided stiffness and basal ganglia calcification in both patients. These twin patients suggest that genetic factors may play an important role in the cause of juvenile Parkinsonism.
authors.affiliation: Department of Neurology, Kagoshima Prefectural Ohshima Hospital.
authors.forename: F
authors.initials: F
authors.lastname: Umehara
authors.forename: M
authors.initials: M
authors.lastname: Nomoto
authors.forename: F
authors.initials: F
authors.lastname: Usuki
authors.forename: W
authors.initials: W
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Osame
mesh_terms: D000328:Adult; D000367:Age Factors; D001479:Basal Ganglia / Q000473:pathology; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D010300:Parkinson Disease / Q000235:genetics* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014430:Twins, Monozygotic
chemical_list: D007980:Levodopa