title: Effect of hyperbaric oxygenation on macrophage function in mice.
abstract: Hyperbaric oxygenation (HBO) has an immunosuppressive effect. The possible mechanisms of this immunosuppressive effect were assessed by determining the production of interleukin-1 (IL-1), interleukin-6 (IL-6), and prostaglandin E2 (PGE2), as well as phagocytosis by splenic macrophages from HBO-treated mice. Although HBO treatment did not have any significant effect on IL-6 production and phagocytotic activity, a marked decrease in IL-1 production and a significant decrease in PGE2 production were observed. These results suggest that the reduction of IL-1 production may play an important role in the immunosuppressive effect of HBO.
authors.affiliation: First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Inamoto
authors.forename: F
authors.initials: F
authors.lastname: Okuno
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: I
authors.initials: I
authors.lastname: Morimoto
authors.forename: U
authors.initials: U
authors.lastname: Yamashita
authors.forename: S
authors.initials: S
authors.lastname: Eto
mesh_terms: D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D006931:Hyperbaric Oxygenation; D007375:Interleukin-1 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D007958:Leukocyte Count; D008264:Macrophages / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H; D010101:Oxygen Consumption; D010587:Phagocytosis / Q000502:physiology; D013154:Spleen / Q000166:cytology
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D015232:Dinoprostone