The Chinese hamster cell mutant V-H4 is homologous to Fanconi anemia (complementation group A).
V-H4, a mitomycin C (MMC)-sensitive Chinese hamster cell mutant, is phenotypically very similar to Fanconi anemia (FA) cells. Genetic complementation analysis shows that V-H4 belongs to the same complementation group as FA group A cells. Proliferating hybrid cell lines obtained after fusion of V-H4 with normal or FA group B cells show an increased resistance to MMC. Absence of complementation was noted in V-H4 x FA group A hybrid cell lines. This was shown not to be due to the absence of a specific human chromosome. The V-H4 mutant represents the first rodent mutant that is genotypically similar to FA complementation group A cells.
Arwert
F
F
Department of Human Genetics, Medical Faculty, Free University, Amsterdam, The Netherlands.
Rooimans
M A
MA
Westerveld
A
A
Simons
J W
JW
Zdzienicka
M Z
MZ
D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D006224:Cricetinae; D003412:Cricetulus; D005199:Fanconi Anemia / Q000235:genetics*; D005816:Genetic Complementation Test; D005838:Genotype; D006801:Humans; D006822:Hybrid Cells / Q000187:drug effects; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009154:Mutation; D010641:Phenotype; D012689:Sequence Homology, Nucleic Acid
D008937:Mitomycins; D016685:Mitomycin