Clathrin light chains: arrays of protein motifs that regulate coated-vesicle dynamics.
Polymerization of clathrin triskelions into clathrin coats and subsequent disassembly by the heat shock protein hsc70 control receptor-mediated pathways of intracellular transport. The clathrin light chains are major regulatory elements in these processes. These polypeptides consist of linear arrays of functional domains with distinctive sequence motifs. Comparison of unicellular and multicellular eukaryotes reveals differences in the numbers of clathrin light chains and in the functional domains they contain.
Brodsky
F M
FM
Department of Pharmacy, School of Pharmacy, University of California, San Francisco 94143-0446.
Hill
B L
BL
Acton
S L
SL
Näthke
I
I
Wong
D H
DH
Ponnambalam
S
S
Parham
P
P
D000595:Amino Acid Sequence; D002118:Calcium / Q000378:metabolism; D002966:Clathrin / Q000235:genetics / Q000502:physiology*; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism*; D004220:Disulfides / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism; D010766:Phosphorylation; D012441:Saccharomyces cerevisiae / Q000235:genetics; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
D002966:Clathrin; D004220:Disulfides; D006360:Heat-Shock Proteins; D002118:Calcium