Inhibition of lactate dehydrogenase isoenzyme associated with anaerobic respiration in schistosomiasis intermediate host snails.
Lactate dehydrogenase isoenzyme (LD5) which is associated with anaerobic respiration was inhibited to a certain degree in Biomphalaria alexandrina snails, the intermediate host for Schistosoma mansoni. Urea and thiourea were used as inhibitors. The effect of LD5 inhibition on the mortality rate of infected Biomphalaria alexandrina snails and on the susceptibility of the snails to the trematode infection was also studied.
Nabih
I
I
Medicinal Chemistry Laboratory, National Research Centre, Dokki, Cairo, Egypt.
el Dardiri
Z
Z
el-Ansary
A
A
D000693:Anaerobiosis / Q000187:drug effects; D000818:Animals; D001700:Biomphalaria / Q000201:enzymology*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors*; D012552:Schistosomiasis / Q000517:prevention & control*; D013890:Thiourea / Q000494:pharmacology; D014508:Urea / Q000494:pharmacology
D007527:Isoenzymes; D014508:Urea; D007770:L-Lactate Dehydrogenase; D013890:Thiourea