title: Extra-weak chemiluminescence of drugs. XI. Quenching effects of purine and pyrimidine derivatives on the extra-weak chemiluminescence derived from the Maillard reaction.
abstract: Quenching effects of purine and pyrimidine derivatives on the extra-weak chemiluminescence (CL) derived from the Maillard reaction of L-lysine with D-arabinose were investigated. The pyrimidine derivatives 2'-deoxy cytidine, uridine, and uracil quenched the CL. Cytidine did not quench the CL. Purine derivatives, e.g. uric acid and 1-methyl adenosine were particularly effective in quenching the CL. 5-Methyl adenine and xanthine also quenched the CL, but adenosine had no effect. A comparison of the CL-quenching abilities of compounds that have common basic structure was made; those with ribose at the 5-position were the strongest quenchers. A linear relationship between CL-quenching activity and the HOMO energy of the pi orbital for the various compounds was shown.
authors.affiliation: Department of Pharmaceutical Sciences, Tohoku University Hospital, Miyagi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kurosaki
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Mizugaki
mesh_terms: D001089:Arabinose; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D008239:Lysine; D011687:Purines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D011687:Purines; D011743:Pyrimidines; D001089:Arabinose; D008239:Lysine