Facilitation of masseter EMG and masseteric (jaw-closure) reflex by serotonin in behaving cats.
The trigeminal motor nucleus (MoV) contains the somata of the motoneurons that control jaw position and jaw movements. This nucleus is of neurochemical interest because it receives a dense serotonergic input. We examined the effects of application of serotonin or fluoxetine, a serotonin reuptake blocker, into this nucleus on the spontaneous or reflex (jaw-closure) electrical activity of the masseter muscle in behaving cats. Serotonin produced a clearcut enhancement of both spontaneous and reflex activities. This action was attenuated by previous systemic injection of the serotonin receptor antagonist methysergide. The effect was mimicked to a certain extent by fluoxetine. These data provide evidence that the serotonergic input to MoV exerts a general facilitatory influence on masseter motoneurons activity.
Ribeiro-do-Valle
L E
LE
Department of Psychology, Princeton University, NJ 08544.
Metzler
C W
CW
Jacobs
B L
BL
D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D004576:Electromyography; D005260:Female; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D012018:Reflex / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*; D014278:Trigeminal Nuclei / Q000187:drug effects / Q000502:physiology*
D012701:Serotonin