[In vitro functional differentiation of hippocampal corticosterone receptors by mineralo- and glucocorticoids].
Modulation of CA1 evoked electrophysiological properties (amplitude, latency, paired-pulse facilitation) by different concentrations of aldosterone (ALDO), spironolactone (SPI), and corticosterone (CT) was studied in hippocampal slice preparation from BALB/c mice. ALDO (5 nM) induced a prolonged increase of the population spike (PS) amplitude with a decrease of its latency and of the paired pulse facilitation. The same effect was observed with a solution of CT (0.5 nM) alone or combined with ALDO (0.5 nM), but no effect was observed with a solution of combined CT (0.5 nM) and SPI (500 nM). Implication of corticosteroid receptors in this response was discussed.
Rey
M
M
Laboratoire de Neurobiologie des Comportements, Université d'Aix-Marseille-I, U.R.A.-C.N.R.S. n. 372, I.H.B.O.P., Marseille.
Carlier
E
E
Talmi
M
M
Soumireu-Mourat
B
B
D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000378:metabolism / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011987:Receptors, Steroid / Q000502:physiology*; D013148:Spironolactone / Q000494:pharmacology*
D011987:Receptors, Steroid; D013148:Spironolactone; D000450:Aldosterone; D003345:Corticosterone
Dissociation fonctionnelle, in vitro, des récepteurs hippocampiques à la corticostérone par les minéralo- et les glucocorticoïdes.