title: Interleukin 2 production in a family with systemic lupus erythematosus and a C4Q0 heterozygous inheritance.
abstract: Interleukin 2 production was studied in a family with systemic lupus erythematosus (SLE) and a C4Q0 heterozygous inheritance. Autoimmune manifestations seemed to be associated with the HLA haplotype containing the C4Q0 allele, which was shared by all four ill family members. Concentrations of interleukin 2, however, did not associate either with the haplotype or with the clinical or serological manifestations, as diminished concentrations of interleukin 2 were found in only two subjects with SLE. Thus the defect in this family seemed to be acquired rather than genetically conditioned.
authors.affiliation: Departamento de Inmunología, Hospital Gregorio Marañón, Universidad Complutense de Madrid.
authors.forename: C
authors.initials: C
authors.lastname: Gutierrez
authors.forename: E
authors.initials: E
authors.lastname: Cabrero
authors.forename: J L
authors.initials: JL
authors.lastname: Vicario
authors.forename: M
authors.initials: M
authors.lastname: Martín Villa
authors.forename: M A
authors.initials: MA
authors.lastname: Rengel
authors.forename: F J
authors.initials: FJ
authors.lastname: Gomez Campdera
authors.forename: M
authors.initials: M
authors.lastname: Yebra
authors.forename: E
authors.initials: E
authors.lastname: Fernández-Cruz
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz Villena
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001327:Autoimmune Diseases / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012859:Sjogren's Syndrome / Q000276:immunology; D013921:Thrombocytopenia / Q000276:immunology
chemical_list: D006680:HLA Antigens; D007376:Interleukin-2