title: An approach to the optimization of preparation of bioprosthetic heart valves.
abstract: The stress and strain states of the valve leaflets during fixation with glutaraldehyde affect their final mechanical parameters. Comparative studies of the stress-strain relationships of aortic valve leaflet strips from fresh, statically and dynamically fixed porcine and human valves were made. Static pressures of 5 mmHg, 16 mmHg, and 95 mmHg result in stress-strain relationships which are in a region between that of fresh porcine and fresh human leaflet strips in the circumferential direction, while they are far from that of fresh porcine tissue (larger strains) in the radial direction. Leaflet strips, fixed under dynamic loading between zero and a predefined maximum load, set at an early post-transition state, give parameters not significantly different from those of human valves.
authors.affiliation: Department of Mechanical Engineering, University of Patras, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Mavrilas
authors.forename: Y
authors.initials: Y
authors.lastname: Missirlis
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001021:Aortic Valve / Q000187:drug effects / Q000502:physiology; D001705:Bioprosthesis; D004548:Elasticity; D005260:Female; D005404:Fixatives; D005976:Glutaral / Q000494:pharmacology; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008422:Materials Testing / Q000379:methods; D011474:Prosthesis Design; D013314:Stress, Mechanical; D013552:Swine; D013718:Tensile Strength; D014783:Viscosity
chemical_list: D005404:Fixatives; D005976:Glutaral