title: Romberg's progressive hemifacial atrophy: an association with scleral melting.
abstract: We report the unusual case of a 43-year-old woman who presented with Romberg's progressive facial hemiatrophy and spontaneous scleral perforation in the ipsilateral eye, for which scleral grafting was performed. Histologic and ultrastructural examination of the scleral specimen revealed a noninflammatory lytic process. The location of the scleral loss, exactly on the line of the "en coup de sabre" atrophy, as well as the light microscopy and ultrastructural histopathologic findings suggest that the scleral destruction was a late manifestation of Romberg's disease.
authors.affiliation: Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114.
authors.forename: T
authors.initials: T
authors.lastname: Hoang-Xuan
authors.forename: C S
authors.initials: CS
authors.lastname: Foster
authors.forename: F A
authors.initials: FA
authors.lastname: Jakobiec
authors.forename: J
authors.initials: J
authors.lastname: Tauber
authors.forename: M
authors.initials: M
authors.lastname: Sainz de la Maza
authors.forename: W
authors.initials: W
authors.lastname: Krebs
mesh_terms: D000328:Adult; D003094:Collagen / Q000648:ultrastructure; D005150:Facial Hemiatrophy / Q000150:complications*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D012590:Sclera / Q000648:ultrastructure; D015422:Scleral Diseases / Q000209:etiology* / Q000473:pathology; D014792:Visual Acuity
chemical_list: D003094:Collagen