Tissue concentration of doxorubicin (adriamycin) in mouse pretreated with alpha-tocopherol or coenzyme Q10.
The tissue concentration of doxorubicin (adriamycin; ADM) and its major metabolite (aglycone I) was examined in mice pretreated with alpha-tocopherol (VE) or coenzyme Q10 (CoQ). In VE-pretreated group, the concentrations of aglycone I of the liver (1, 3 and 5 h after the administration), kidney (1 and 3h) and heart (3h) were significantly higher than those in the saline group. The clinical application of VE or CoQ concomitant with anti-tumor drugs especially ADM, requires caution.
Shinozawa
S
S
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Gomita
Y
Y
Araki
Y
Y
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003067:Coenzymes; D004317:Doxorubicin / Q000493:pharmacokinetics*; D005453:Fluorescence; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009994:Osmolar Concentration; D013053:Spectrophotometry; D014451:Ubiquinone / Q000494:pharmacology* / Q000031:analogs & derivatives; D014810:Vitamin E / Q000494:pharmacology*
D003067:Coenzymes; D014451:Ubiquinone; D014810:Vitamin E; D004317:Doxorubicin; C024989:coenzyme Q10