Pheochromocytoma with pyrexia and marked inflammatory signs: a paraneoplastic syndrome with possible relation to interleukin-6 production.
Pheochromocytoma can cause several paraneoplastic syndromes. We report a patient with pheochromocytoma who exhibited pyrexia and marked inflammatory signs along with an elevated serum interleukin-6 (IL-6) level. All of these abnormalities disappeared and serum IL-6 became undetectable by removal of the tumor. In addition, immunohistochemical analysis revealed the presence of IL-6 in the tumor cells. It is suggested that pyrexia and the elevation of acute phase proteins can be a paraneoplastic syndrome with pheochromocytoma, and that the elaboration of IL-6 from pheochromocytoma may play an important role in the development of the syndrome.
Fukumoto
S
S
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
Matsumoto
T
T
Harada
S
S
Fujisaki
J
J
Kawano
M
M
Ogata
E
E
D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005334:Fever / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000378:metabolism* / Q000502:physiology; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000378:metabolism / Q000473:pathology*; D010673:Pheochromocytoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology
D015850:Interleukin-6