Chicken growth hormone, triiodothyronine and thyrotropin releasing hormone modulation of the levels of chicken natural cell-mediated cytotoxicity.
Newly hatched White Leghorn male chicks received dietary supplements of either Triiodothyronine (T3) or Thyrotropin Releasing Hormone (TRH) until 8 weeks of age. Chicken growth hormone (cGH) (10 micrograms/kg BW) was injected into different chicks twice daily for 1 week starting at 7 weeks of age. Separate groups received both T3 and cGH. Natural cell-mediated cytotoxic (NCMC) activity against different target cells was tested. It was found that cytotoxic activity in cells involved in NCMC against P815 mouse mastocytoma was stimulated by cGH alone or in combination with T3 (1 ppm). These findings indicate that cGH and T3 stimulate NCMC activity; and that the cells responsible for this activity may be Natural Killer (NK) cells.
Haddad
E E
EE
Department of Poultry Science, Pennsylvania State University, University Park 16802.
Mashaly
M M
MM
D000818:Animals; D002478:Cells, Cultured; D002645:Chickens / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D013006:Growth Hormone / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008297:Male; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone