title: Vancomycin-resistant Enterococcus faecalis in a bone-marrow transplant recipient.
abstract: Since 1988 a number of reports on the emergence of vancomycin-resistant enterococci have been published. We describe an additional case of colonization of and subsequent infection with a vancomycin-resistant Enterococcus faecalis in a bone-marrow transplant recipient, who had never before received vancomycin therapy. The strain was resistant to most antibiotics tested, including low-level resistance to gentamicin and cross-resistance to teicoplanin. It was sensitive to amoxicillin and the lipopeptide antibiotic daptomycin. The origin, the mode of acquisition and the incidence of vancomycin-resistant enterococci are still unknown. The clinical and bacteriological features of the cases reported thus far and the genetic and biochemical basis of vancomycin resistance are discussed.
authors.affiliation: Department of Infectious Diseases, University Hospital Leiden, The Netherlands.
authors.forename: W E
authors.initials: WE
authors.lastname: Peetermans
authors.forename: F W
authors.initials: FW
authors.lastname: Sebens
authors.forename: H F
authors.initials: HF
authors.lastname: Guiot
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000494:pharmacology / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects*; D005260:Female; D006801:Humans; D013290:Streptococcal Infections / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D014640:Vancomycin; D000658:Amoxicillin