title: The GTPase superfamily: conserved structure and molecular mechanism.
abstract: GTPases are conserved molecular switches, built according to a common structural design. Rapidly accruing knowledge of individual GTPases--crystal structures, biochemical properties, or results of molecular genetic experiments--support and generate hypotheses relating structure to function in other members of the diverse family of GTPases.
authors.affiliation: Department of Pharmacology, University of California, San Francisco 94143-0450.
authors.forename: H R
authors.initials: HR
authors.lastname: Bourne
authors.forename: D A
authors.initials: DA
authors.lastname: Sanders
authors.forename: F
authors.initials: F
authors.lastname: McCormick
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D020963:GTP Phosphohydrolase-Linked Elongation Factors / Q000502:physiology* / Q000648:ultrastructure; D019204:GTP-Binding Proteins / Q000378:metabolism; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D010445:Peptide Elongation Factors / Q000378:metabolism; D010448:Peptide Initiation Factors / Q000378:metabolism; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D010445:Peptide Elongation Factors; D010448:Peptide Initiation Factors; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate; D020963:GTP Phosphohydrolase-Linked Elongation Factors; D019204:GTP-Binding Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)