Clonal analysis of the relationship between class II MHC-restricted cytolysis and lymphokine secretion in murine L3T4+ T cells.
A panel of peptide-specific murine CD4+ T-cell clones was tested for lymphokine secretion, antigen-specific cytolysis and CD3-mediated cytolysis. The data indicated an imperfect correlation between Th1/Th2 status with regard to antigen-specific cytolysis but also indicated that all the clones were cytotoxic when stimulated with anti-CD3 antibody.
Gao
X M
XM
Department of Experimental Immunobiology, Wellcome Biotech, Beckenham, Kent, U.K.
Liew
F Y
FY
Bottomly
K
K
Meager
A
A
Tite
J P
JP
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002460:Cell Line; D002999:Clone Cells / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D005260:Female; D005802:Genes, MHC Class II / Q000276:immunology*; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D008222:Lymphokines / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D007376:Interleukin-2; D008222:Lymphokines; D015847:Interleukin-4; D007371:Interferon-gamma