title: Quantitative genetics of postponed aging in Drosophila melanogaster. II. Analysis of selected lines.
abstract: Quantitative genetic analyses of Drosophila melanogaster stocks with postponed aging have suffered from the problem of a lack of certainty concerning patterns of allelic differentiation. The present experiments were designed to alleviate this difficulty by selecting for enhanced levels of characters known to be related to postponed aging. Selection successfully increased the degree of differentiation of postponed aging stocks with respect to starvation resistance and fecundity, but persistent additive genetic variance suggested that selection did not result in fixation of alleles. The artificially selected stocks were subjected to crosses to test for patterns of dominance and maternal effects. There was little evidence for these effects in the inheritance of the characters underlying postponed aging, even with the increased differentiation of the selected stocks.
authors.affiliation: Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: E W
authors.initials: EW
authors.lastname: Hutchinson
authors.forename: A J
authors.initials: AJ
authors.lastname: Shaw
authors.forename: M R
authors.initials: MR
authors.lastname: Rose
mesh_terms: D000375:Aging / Q000235:genetics; D000483:Alleles; D000704:Analysis of Variance; D000818:Animals; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D005260:Female; D005298:Fertility / Q000235:genetics; D005799:Genes, Dominant / Q000235:genetics; D014644:Genetic Variation; D008136:Longevity / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic; D012641:Selection, Genetic; D013217:Starvation