title: Results of radiotherapy for localised prostatic carcinoma treated at the Prince of Wales Hospital, Sydney.
abstract: Between 1980 and 1986 a total of 218 patients with localised prostatic carcinoma received radical pelvic radiotherapy at The Prince of Wales Hospital, Sydney. The mean follow-up time was 4.6 years. The five-year actuarial overall survival rate was 63% (death from all causes) and the five-year cancer-specific survival rate was 73% (death from or with prostate cancer). The overall survival was significantly worse with more advanced clinical stage of the disease (P = 0.003) and with poor histological differentiation of the tumour (P = 0.001). The five-year actuarial rate for local control of tumour in the pelvis was 84%. Late treatment-related complications (occurring or persisting beyond six months) were mild or moderate and the majority settled with conservative management. Only five patients experienced severe complications (necessitating surgical treatment). Of 42 patients with normal potency documented before radiotherapy who were not subsequently hormonally manipulated 23 (55%) retained potency at two years. These results for definitive radiotherapy for localised prostatic carcinoma indicate good local control with minimal morbidity and compare favourably with other published results.
authors.affiliation: Department of Radiation Oncology, Prince of Wales Hospital, Randwick, NSW.
authors.forename: H
authors.initials: H
authors.lastname: Mameghan
authors.forename: R
authors.initials: R
authors.lastname: Fisher
authors.forename: W H
authors.initials: WH
authors.lastname: Watt
authors.forename: M J
authors.initials: MJ
authors.lastname: Meagher
authors.forename: M
authors.initials: M
authors.lastname: Rosen
authors.forename: R H
authors.initials: RH
authors.lastname: Farnsworth
authors.forename: A
authors.initials: A
authors.lastname: Tynan
authors.forename: J
authors.initials: J
authors.lastname: Mameghan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects; D002277:Carcinoma / Q000473:pathology / Q000532:radiotherapy*; D005500:Follow-Up Studies; D006786:Hospitals, Urban; D006801:Humans; D007410:Intestinal Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009517:New South Wales; D010410:Penile Erection / Q000528:radiation effects; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011881:Radiotherapy, Computer-Assisted; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D012189:Retrospective Studies; D015996:Survival Rate