The larvicidal activity of cyclosporin A against Schistosoma mansoni in mice.
Treatment of BALB/c or MF1 mice with cyclosporin A (CsA) around the time of infection with Schistosoma mansoni conferred almost complete protection. The migration kinetics of L-[75Se]selenomethionine-labelled infective cercariae were investigated by compressed tissue autoradiography. Similar levels of skin penetration were achieved by cercariae in control and drug-treated individuals. CsA arrested 87-94% of the worms in the skin and ultimately all of these died in this site. Few worms (7-14%) migrated from the skin to the lungs and none completed migration to the liver. Nevertheless, the autoradiograms revealed a limited degree of lateral cutaneous migration by the worms present in the skins of CsA-treated mice. Results of perfusion recovery experiments carried out during the course of infection reinforced the tracking data.
Munro
G H
GH
Division of Parasitology, National Institute for Medical Research, Mill Hill, London.
Brannan
L R
LR
Chappell
L H
LH
Thomson
A W
AW
McLaren
D J
DJ
D000818:Animals; D001345:Autoradiography; D003524:Cyclosporins / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006790:Host-Parasite Interactions; D007814:Larva / Q000187:drug effects; D008099:Liver / Q000469:parasitology; D008168:Lung / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012550:Schistosoma mansoni / Q000187:drug effects*; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000469:parasitology*; D012867:Skin / Q000469:parasitology; D013997:Time Factors
D003524:Cyclosporins