title: Spike voltage topography identifies two types of frontotemporal epileptic foci.
abstract: We characterized voltage topography of frontotemporal EEG spikes in 24 patients with complex partial seizures and identified two distinct patterns. "Type 1" spikes possessed a "dipolar" field with a negative region over the inferolateral temporal scalp and a positive region over the contralateral, centroparietal scalp. "Type 2" spikes showed only a broad, frontotemporal negative field. One or the other spike type predominated in all but two patients. Correlations with clinical data and intracranial EEG suggest that type 2 spikes arise from temporal or frontal neocortex, while type 1 spikes involve mesial temporal structures as well as lateral cortex.
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: J S
authors.initials: JS
authors.lastname: Ebersole
authors.forename: P B
authors.initials: PB
authors.lastname: Wade
mesh_terms: D000200:Action Potentials; D001931:Brain Mapping; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D010296:Parietal Lobe / Q000503:physiopathology