[The effect of amino acid substitutions on the 3-dimensional structure of fragment 1--16 of the oncoprotein p21 ras].
Using the method of theoretical conformational analysis, spatial structure of fragment 1-16 of active [( Val12-Gly13], [Asp12-Gly13], [Gly12-Asp13]) and passive [( Gly12-Gly13] and [Pro12-Gly13]) modifications of oncoproteins family p21 ras have been investigated. The activation of these proteins has been shown to be accompanied by reorganization of three-dimensional structure of the polypeptide chain.
Mzareulov
K D
KD
D000596:Amino Acids / Q000737:chemistry*; D006801:Humans; D015689:Oncogene Protein p21(ras) / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D000596:Amino Acids; D010446:Peptide Fragments; D015689:Oncogene Protein p21(ras)
Vliianie aminokislotnykh zamen na prostranstvennoe stroenie fragmenta 1--16 onkobelka p21 ras.