[A case of two successful deliveries by a woman with Kallmann syndrome and NIDDM].
A 37 year-old female with Kallmann syndrome and NIDDM who had two successful deliveries is reported. She had experienced no menstruation until she had treatment with gestagen in her early twenties. She had withdrawal bleeding only once. At the age of 25, she consulted her family doctor, complaining of amenorrhea. Estrogen progesterone cyclic therapy caused withdrawal bleeding, and clomiphene citrate failed to induce apparent ovulation. In January 1978, 150 IU of hMG was administered daily for 9 days, and then 3000 IU of hCG daily for the following 2 days. This therapy induced pregnancy, which failed spontaneously on June 4th. A year later, in January 1979, 150 IU of hMG was again administered daily for 7 days followed by 6000 IU of hCG for 3 days. This therapy again induced pregnancy. On September 27th, 1979, she delivered a girl vaginally, weighing 3830 g. After this delivery, she experienced no menstruation. In June 1985, she consulted her family doctor again, and she was diagnosed as being pregnant. Since her fasting blood glucose was 145 mg/dl, she was admitted to Kosei Hospital to control her blood glucose. On October 15th, she delivered a girl weighing 2600 g. On June 13th, 1989, she was referred to Kosei Hospital by her family doctor to achieve an accurate control of her blood glucose. During this admission, she was diagnosed as having Kallmann syndrome because of congenital anosmia and hypogonadotropic hypogonadism without any abnormal morphological changes. Vitamin B1 infusion test was negative.(ABSTRACT TRUNCATED AT 250 WORDS)
Mano
T
T
Department of Internal Medicine, Anjo Kosei Hospital, Aichi, Japan.
Yamamoto
M
M
Suzuki
K
K
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007006:Hypogonadism / Q000503:physiopathology*; D007743:Labor, Obstetric; D008596:Menotropins / Q000008:administration & dosage; D009422:Nervous System Diseases / Q000503:physiopathology / Q000628:therapy; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology* / Q000628:therapy; D012903:Smell; D013577:Syndrome
D006063:Chorionic Gonadotropin; D008596:Menotropins