title: Osteoblastoma response to chemotherapy.
abstract: An 8-year-old boy had an osteoblastoma of the body of C2. After attempted excision, the tumor recurred rapidly and massively. The tumor shrank progressively after treatment with high-dose methotrexate, doxorubicin, and cisplatin. The patient has stopped treatment and been stable for 33 months. Surgical excision remains the treatment of choice for osteoblastoma. Chemotherapy may be useful in selected patients with a recurrent, aggressive tumor or in patients with surgically inaccessible disease.
authors.affiliation: Department of Pediatrics, Midwest Children's Cancer Center, Milwaukee, WI 53226.
authors.forename: B
authors.initials: B
authors.lastname: Camitta
authors.forename: R
authors.initials: R
authors.lastname: Wells
authors.forename: A
authors.initials: A
authors.lastname: Segura
authors.forename: K K
authors.initials: KK
authors.lastname: Unni
authors.forename: K
authors.initials: K
authors.lastname: Murray
authors.forename: D
authors.initials: D
authors.lastname: Dunn
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy*; D002574:Cervical Vertebrae; D002648:Child; D004305:Dose-Response Relationship, Drug; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D010017:Osteoma, Osteoid / Q000188:drug therapy*
chemical_list: D008727:Methotrexate