title: Continual trending of Fick variables in the critically ill patient.
abstract: We continually monitored components of the Fick equation (oxygen consumption, arterial and mixed venous oxygen saturation) simultaneously in ten hemodynamically stable, mechanically ventilated postoperative patients in order to evaluate our ability to continually calculate cardiac output (Qc) from its Fick determinants. Qc underestimated (p less than 0.001) cardiac output calculated from intermittent CO-oximeter measurements (6.2 vs 6.4 L/min) with good correlation (r = .96), while it consistently overestimated (p less than 0.05) thermodilution cardiac output (Qtd) (6.2 vs 5.9 L/min, r = .84). Measured oxygen consumption correlated with Qtd (r = .78) nearly as well as did Qc, while mixed venous oxygen saturation correlated poorly with Qtd (r = -.10). Trends of multiple Fick variables were helpful in interpreting changes in a single parameter. We conclude that continual trending of Fick variables in critically ill patients is both feasible and useful and that Qc agrees well with both traditional Fick cardiac output computed from CO-oximetry data and thermodilution measurements. Finally, measured oxygen consumption, available continuously, correlates well with changes in cardiac output in this subset of critically-ill patients.
authors.affiliation: Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York.
authors.forename: T J
authors.initials: TJ
authors.lastname: Quinn
authors.forename: C
authors.initials: C
authors.lastname: Weissman
authors.forename: M
authors.initials: M
authors.lastname: Kemper
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015982:Bias; D002245:Carbon Dioxide / Q000378:metabolism; D002302:Cardiac Output; D002407:Catheterization, Swan-Ganz; D003422:Critical Care; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011651:Pulmonary Artery; D013815:Thermodilution
chemical_list: D006454:Hemoglobins; D002245:Carbon Dioxide; D010100:Oxygen