Gingival hyperplasia: a side effect of nifedipine and diltiazem.
Currently, calcium channel blockers are being used increasingly for the treatment of hypertension in the elderly. Several case reports in the dental literature suggest that patients treated with the calcium channel blockers manifest gingival hyperplasia similar to that seen in patients taking phenytoin (Dilantin, Parke-Davis). A small study of 89 patients undertaken at the Westside Veterans Administration Medical Center, Chicago seems to indicate that nifedipine and diltiazem do indeed cause gingival hyperplasia. A total of 83% of the patients studied receiving nifedipine showed evidence of hyperplastic tissue and 74% of those on diltiazem were found to have hyperplastic tissue.
Fattore
L
L
West Side VA Medical Center, Chicago.
Stablein
M
M
Bredfeldt
G
G
Semla
T
T
Moran
M
M
Doherty-Greenberg
J M
JM
D000368:Aged; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D004110:Diltiazem / Q000009:adverse effects; D005885:Gingival Hyperplasia / Q000139:chemically induced*; D006801:Humans; D009543:Nifedipine / Q000009:adverse effects; D014700:Verapamil / Q000009:adverse effects
D002121:Calcium Channel Blockers; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine