Differences in lipogenesis in tissues of control and gold-thioglucose obese mice after an isocaloric meal.
Lipogenesis was measured in 2 and 5 week gold-thioglucose (GTG) obese mice after a single meal of 0.5 g of standard chow. Compared to control mice the rate of lipogenesis in GTG obese mice, was 4-fold higher in liver and 10-fold higher in white adipose tissue (WAT). In brown adipose tissue (BAT) of GTG-injected mice the lipogenic rate was only 50% of that of controls. These results indicate that the increased lipid synthesis observed in GTG-injected mice is not due solely to hyperphagia and that some other stimuli, such as increased basal insulin levels and/or decreased thermogenesis and insulin resistance in BAT, contribute to the high rates of fat synthesis in this animal model of obesity.
Blair
S C
SC
Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, N.S.W. Australia.
Cooney
G J
GJ
Denyer
G S
GS
Williams
P F
PF
Caterson
I D
ID
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D006051:Aurothioglucose / Q000494:pharmacology*; D002149:Energy Intake; D050356:Lipid Metabolism; D008055:Lipids / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008820:Mice, Obese; D009765:Obesity / Q000209:etiology / Q000378:metabolism*
D008055:Lipids; D006051:Aurothioglucose