Combined growth hormone and gonadotropin treatment for ovulation induction in patients with non-responsive ovaries.
Four anovulatory patients who did not respond to large doses of hMG over 18-33 days were co-treated in subsequent cycles with human growth hormone. Treatment with growth hormone markedly raised serum insulin-like growth factor concentrations. Two patients had a dramatic ovarian response within 7 days of co-treatment; two menopausal patients did not respond. This combined therapy may be of practical value for ovulation induction in non-menopausal patients with non-responsive ovaries.
Homburg
R
R
Cobbold Laboratories, Middlesex Hospital, London, UK.
West
C
C
Ostergaard
H
H
Jacobs
H S
HS
D000224:Addison Disease / Q000150:complications; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D007006:Hypogonadism / Q000150:complications; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008593:Menopause / Q000187:drug effects; D008596:Menotropins / Q000494:pharmacology*; D006080:Ovarian Follicle / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods*; D014599:Uterus / Q000187:drug effects
D008596:Menotropins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone