Impaired venodilatation due to nitroglycerine in patients after heart transplantation.
The effect of nitroglycerin on forearm peripheral vessels was assessed in three groups of patients: in patients after orthotopic heart transplantation, in patients with severe heart insufficiency and a control group. The effect on arterioles was similar in all investigated groups, the most pronounced arteriodilatation being observed in fifth minute after the application. However, the effect on veins was different. Significant venodilatation was observed only in controls, while in the other groups was not present. Thus impairment in venodilatation was revealed in both the patients after heart transplantation and in patients with severe heart failure.
Petrasko
M
M
Institute for Clinical and Experimental Medicine, Cardiovascular Research Programme, Prague, Czechoslovakia.
Prerovský
I
I
Kocandrle
V
V
D000328:Adult; D005260:Female; D005542:Forearm / Q000098:blood supply; D006333:Heart Failure / Q000503:physiopathology; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology
D005996:Nitroglycerin