title: Induction of anesthesia with diazepam-ketamine and midazolam-ketamine in greyhounds.
abstract: Anesthesia was induced in 14 greyhounds with a mixture of diazepam or midazolam (0.28 mg/kg) and ketamine (5.5 mg/kg), and maintained with halothane. There were no significant differences in weight, age, or duration of anesthesia between the treatment groups. Time to intubation with diazepam-ketamine (4.07 +/- 1.43 min) was significantly longer than with midazolam-ketamine (2.73 +/- 0.84 min). Heart rate, respiratory rate, PaCO2, and arterial pH did not vary significantly during anesthesia in either treatment group. Arterial blood pressures, PaO2, halothane vaporizer setting, and body temperature changed significantly from baseline values in both treatment groups during anesthesia. Times to sternal recumbency and times to standing were not significantly different. These data suggest that both diazepam-ketamine and midazolam-ketamine are useful anesthetic combinations in greyhounds. In combination with ketamine, midazolam offers little advantage over diazepam.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus.
authors.forename: P W
authors.initials: PW
authors.lastname: Hellyer
authors.forename: L C
authors.initials: LC
authors.lastname: Freeman
authors.forename: J A
authors.initials: JA
authors.lastname: Hubbell
mesh_terms: D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D003975:Diazepam; D004283:Dog Diseases / Q000139:chemically induced; D004285:Dogs / Q000502:physiology*; D004338:Drug Combinations; D004562:Electrocardiography / Q000662:veterinary; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects; D007649:Ketamine; D008874:Midazolam; D009207:Myoclonus / Q000139:chemically induced / Q000662:veterinary; D010100:Oxygen / Q000097:blood; D012119:Respiration / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D002245:Carbon Dioxide; D007649:Ketamine; D003975:Diazepam; D008874:Midazolam; D010100:Oxygen; D006221:Halothane