Taste impairment for glucose in diabetic PTC tasters and non-tasters.
Effect of high blood glucose levels in diabetes mellitus was studied on gustatory responses to glucose in PTC tasters and non-tasters, before and after the ingestion of a glucose solution. After a 12-h overnight fast, prescreening for phenylthiocarbamide (PTC) sensitivity was done in each subject, and then each subject tasted, and rated, 7 concentrations of glucose solutions for intensity and hedonic responses. Blood glucose levels were also determined under fasting and then after a 100-g glucose load. A decrease in palatability of the glucose solutions induced by the glucose load (negative alliaesthesia) was evident in both groups of subjects. Tasters showed higher hedonic ratings (Mean 4-25), as compared to non-tasters (Mean 3-70) and this difference was more evident after the glucose load in non-tasters.
Bhatia
S
S
Department of Physiology, University College of Medical Sciences, Shahdara, Delhi, India.
Sharma
K N
KN
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000502:physiology; D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology*; D005215:Fasting; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D010670:Phenylthiourea / Q000378:metabolism*; D013649:Taste / Q000502:physiology*; D013651:Taste Disorders / Q000503:physiopathology*; D013997:Time Factors
D001786:Blood Glucose; D010670:Phenylthiourea; D005947:Glucose