[Epidermal growth factor (EGF) receptors in squamous cell carcinoma of the head and neck region].
The expression of epidermal growth factor receptors (EGFR) has been studied immunohistochemically in 66 squamous cell carcinomas of the head and neck. All investigated tumours overexpressed EGFR showing a homogenous distribution pattern. Pretreatment of tumours (eg. chemotherapy or radiation) did not influence this result. Our findings indicate that EGFR expression is not strongly correlated to proliferative activity, and is not suited to be used as a prognostic marker. It is possible that the observed overexpression of EGFR in squamous cell carcinomas of head and neck can be used as a target for ligand-complexed drugs.
Lörz
M
M
Zentrum der Hals-Nasen-Ohren-Heilkunde, Universitätskliniken Frankfurt/Main.
Bettinger
R
R
Meyer-Breiting
E
E
D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D066246:ErbB Receptors / Q000032:analysis*; D006258:Head and Neck Neoplasms / Q000737:chemistry*; D006801:Humans; D011379:Prognosis
D014408:Biomarkers, Tumor; D066246:ErbB Receptors
Epidermal Growth Factor (EGF)-Rezeptoren bei Plattenepithelkarzinomen aus dem Kopf-Hals-Bereich.