title: Norepinephrine-stimulated phosphatidylinositol metabolism in genetically epilepsy-prone and kindled rats.
abstract: Genetically epilepsy-prone rats (GEPR-9) and kindled rats have reduced noradrenergic function. In the present study, norepinephrine-stimulated accumulation of inositol phosphates was reduced in cerebral cortex of GEPR-9 and kindled rats when compared to control and non-kindled rats, respectively. No such reduction was found in amygdala/pyriform cortex and hippocampus. These results support the hypothesis that cortical noradrenergic and associated second messenger systems are impaired in epilepsy.
authors.affiliation: Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
authors.forename: D L
authors.initials: DL
authors.lastname: Yourick
authors.forename: M C
authors.initials: MC
authors.lastname: LaPlaca
authors.forename: J L
authors.initials: JL
authors.lastname: Meyerhoff
mesh_terms: D000818:Animals; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism*; D007696:Kindling, Neurologic; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D009994:Osmolar Concentration; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D010716:Phosphatidylinositols; D009638:Norepinephrine