[Systolic time intervals and echocardiography in monitoring adriamycin-treated tumor patients].
By means of systolic time intervals (PEP/LVET) and echocardiography (Vfr) 218 tumour patients were controlled concerning a cardiomyopathy induced by cytostatic agents. 13% of the patients (28/218) transgressed an absolute cumulative dose of 1,000 mg of doxorubicin or daunorubicin, of which, however, 12% (26/218) showed normal values for PEP/LVET. 11% of the patients (24/218) showed pathologic PEP/LVET values in 6% (49/787) of the investigations, in which case in 15 patients the clinical diagnosis of a cardiomyopathy could be assumed with simultaneously decreased shortening fraction. The sex and age distribution of this group corresponded to that one of the total cohort. The investigation presented confirm the value of systolic time intervals and of echocardiography as screening methods for a cardiomyopathy and speak against a general establishment of a borderline diagnosis.
Schott
G
G
III. Medizinische Klinik, Bezirkskrankenhauses Heinrich Braun, Zwickau.
D000328:Adult; D000368:Aged; D002302:Cardiac Output / Q000187:drug effects*; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000000981:diagnostic imaging; D003630:Daunorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013599:Systole / Q000187:drug effects*; D016277:Ventricular Function, Left / Q000187:drug effects*
D004317:Doxorubicin; D003630:Daunorubicin
Systolische Zeitintervalle und Echokardiographie in der Uberwachung adriamycinbehandelter Tumorpatienten.