[The effect of cyclosporin A and oligomycin on the nonspecific permeability of the mitochondria inner membrane].
The effect of oligomycin and cyclosporine A on Ca(2+)-induced nonspecific permeability of the inner mitochondrial membrane was under study. Both oligomycin and cyclosporine A were able to prevent the activation of nonspecific permeability; however, but cyclosporine A was the only agent which could restore the initial permeability of the inner mitochondrial membrane. The effect of cyclosporine A was not shown to be mediated through redistribution of Ca2+ ions between different subpopulations of mitochondria.
Novgorodov
S A
SA
Gudz'
T I
TI
Zorov
D B
DB
Kushnareva
Iu E
IuE
Kudriashov
Iu B
IuB
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism; D003524:Cyclosporins / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects / Q000502:physiology; D008930:Mitochondria, Liver / Q000187:drug effects*; D009840:Oligomycins / Q000494:pharmacology*; D010539:Permeability / Q000187:drug effects; D051381:Rats
D003524:Cyclosporins; D009840:Oligomycins; D002118:Calcium
Deĭstvie tsiklosporina A i oligomitsina na nespetsificheskuiu pronitsaemost' vnutrenneĭ membrany mitokhondriĭ.