Activity of buparvaquone against Theileria cervi in white-tailed deer.
Buparvaquone, a naphthoquinone with known efficacy against Theileria parva parva in cattle, was tested for activity against Theileria cervi piroplasms in both an in vitro culture system and in vivo in experimentally infected white-tailed deer. The in vitro data showed a significant decrease in the incorporation of 3H-hypoxanthine by infected red blood cells treated with buparvaquone when compared to that seen with imidocarb and chloroquine treatment. In both intact and splenectomized deer treated with buparvaquone (2.5 mg kg-1) a gradual decrease in piroplasm parasitaemia was observed following treatment. However, in the splenectomized deer, parasitaemia levels returned to near pretreatment values after approximately 2 weeks.
Mitema
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Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078.
Kocan
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AA
Mukolwe
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SW
Sangiah
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Sherban
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D
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016782:Apicomplexa / Q000187:drug effects* / Q000502:physiology; D002478:Cells, Cultured; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use; D003670:Deer / Q000469:parasitology*; D004912:Erythrocytes / Q000469:parasitology; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D007095:Imidocarb / Q000494:pharmacology / Q000627:therapeutic use; D009285:Naphthoquinones / Q000494:pharmacology* / Q000627:therapeutic use; D013801:Theileriasis / Q000188:drug therapy*
D000981:Antiprotozoal Agents; D007042:Hypoxanthines; D009285:Naphthoquinones; C046326:buparvaquone; D019271:Hypoxanthine; D002738:Chloroquine; D007095:Imidocarb