title: Early clinical neurochemistry of CNS-active drugs. Bromides.
abstract: The use of bromides in medicine dates back to the beginning of the 19th century. The salts were used in neurological and mental diseases, particularly in epilepsy, up until their partial replacement by phenobarbital and ultimate displacement by dilantin. This article reviews the analytical methodology as it developed historically, and traces the application of chemical analysis of body fluids to monitoring for bromide toxicity (bromism) and then to investigation of the blood-brain barrier in various disorders of the central nervous system.
authors.affiliation: Department of Psychiatry, McGill University Faculty of Medicine, West, Montreal, Canada.
authors.forename: T L
authors.initials: TL
authors.lastname: Sourkes
mesh_terms: D001923:Brain Chemistry / Q000187:drug effects*; D001965:Bromides / Q000009:adverse effects / Q000266:history* / Q000494:pharmacology / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy / Q000266:history; D049672:History, 19th Century; D006801:Humans
chemical_list: D001965:Bromides