[No rearrangement of the breakpoint cluster region in two juvenile chronic myeloid leukemia].
We performed cytogenetic studies and breakpoint cluster region (bcr) rearrangement analysis in two cases of juvenile chronic myeloid leukemia (JCML) which is special type of chronic myeloid leukemia (CML). Case 1 (8-month-old male) and case 2 (3-month-old female) showed clinical and hematologic manifestations similar to CML. Each of case 1 and 2 had normal karyotype and no bcr rearrangement. These findings suggest that JCML is a different heterogeneous disorder from that of adult CML.
Nakamura
H
H
Department of Internal Medicine, Atomic Disease Institute, Nagasaki University School of Medicine.
Tokunaga
S
S
Sadamori
N
N
Tomonaga
M
M
Ichimaru
M
M
Kinoshita
K
K
Yanai
M
M
Tsuji
Y
Y
Shimizu
S
S
D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007223:Infant; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D005810:Multigene Family