Effect of ethyl apovincaminate on the utilization of 14C-glucoses by rat brain in vitro.
The effect of the presence of 500 micrograms ethyl epovincaminate (Cavinton) on the aerobic metabolism of 14C-labelled glucoses was studied in vitro. The drug tested increased the metabolism of [1-14C]-D-glucose first of all, which indicated a significant activation of pentose-phosphate shunt.
Matkovics
B
B
Biological Isotope Laboratory, Atilla József University, Szeged, Hungary.
Szabó
L
L
Kiss
B
B
Szpornyi
L
L
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002245:Carbon Dioxide / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014748:Vinca Alkaloids / Q000494:pharmacology*
D010726:Phosphodiesterase Inhibitors; D014748:Vinca Alkaloids; D002245:Carbon Dioxide; C013983:vinpocetine; D005947:Glucose