title: Changes in serum erythropoietin levels during allogeneic bone marrow transplantation.
abstract: Serial serum erythropoietin levels were measured in 10 consecutive patients undergoing allogeneic bone marrow transplantation. Observed erythropoietin levels are compared with those predicted from a large control population of anaemic patients not receiving chemotherapy. There was an initial acute rise in serum erythropoietin, peaking between days 1 and 4 after marrow transfusion, which was unrelated to changes in haemoglobin concentration. Patients maintained serum erythropoietin concentrations at around twice the predicted level for the first 2 weeks following transplantation, with a gradual fall into the expected range by wk 3. Erythropoietin levels did not change with episodes of bacterial infection or acute graft-versus-host disease. A patient with severe aplastic anaemia had initial successful engraftment with normalisation of erythropoietin levels, but showed a marked and amplified rise in erythropoietin 2 wk before falling peripheral blood counts indicated failure of the bone marrow graft.
authors.affiliation: Department of Haematology, General Infirmary, Leeds, U.K.
authors.forename: R J
authors.initials: RJ
authors.lastname: Grace
authors.forename: R G
authors.initials: RG
authors.lastname: Kendall
authors.forename: C
authors.initials: C
authors.lastname: Chapman
authors.forename: A E
authors.initials: AE
authors.lastname: Hartley
authors.forename: D L
authors.initials: DL
authors.lastname: Barnard
authors.forename: D R
authors.initials: DR
authors.lastname: Norfolk
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000601:surgery; D001853:Bone Marrow / Q000000981:diagnostic imaging; D016026:Bone Marrow Transplantation / Q000502:physiology*; D002648:Child; D003524:Cyclosporins / Q000627:therapeutic use; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011859:Radiography; D011863:Radioimmunoassay
chemical_list: D003524:Cyclosporins; D006454:Hemoglobins; D004921:Erythropoietin