The actions of NSAIDs.
The ability of aspirin and related drugs to inhibit prostaglandin biosynthesis accounts for many effects of NSAIDs but does not completely explain their efficacy against inflammation. An additional mechanism may be disruption of the intracellular signal pathways responsible for activation of inflammatory cells--notably, neutrophils.
Weissmann
G
G
Division of Rheumatology, New York University School of Medicine.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects / Q000276:immunology; D002462:Cell Membrane / Q000187:drug effects / Q000276:immunology; D004347:Drug Interactions; D019204:GTP-Binding Proteins / Q000187:drug effects / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008565:Membrane Proteins / Q000187:drug effects / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000096:biosynthesis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008565:Membrane Proteins; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D019204:GTP-Binding Proteins