title: Isolation and identification of alpha-(beta-alanyl)hypusine from bovine brain.
abstract: A unique dipeptide was isolated from bovine brain using five steps of ion-exchange chromatography. Its acid hydrolysate contained equimolar amounts of beta-alanine and hypusine. The structure of the peptide was elucidated as alpha-(beta-alanyl)hypusine using dansylation technique. About 1 mumol of the compound was isolated from 1090 g of bovine brain.
authors.affiliation: Department of Neuropsychiatry, Ehime University, School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ueno
authors.forename: K
authors.initials: K
authors.lastname: Kotani
authors.forename: A
authors.initials: A
authors.lastname: Sano
authors.forename: Y
authors.initials: Y
authors.lastname: Kakimoto
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D004151:Dipeptides / Q000302:isolation & purification*; D008239:Lysine / Q000031:analogs & derivatives* / Q000737:chemistry; D015091:beta-Alanine / Q000737:chemistry*
chemical_list: D004151:Dipeptides; D015091:beta-Alanine; C067248:alpha-(beta-alanyl)hypusine; C100028:hypusine; D008239:Lysine