Analysis of pancreatic serum markers in patients with cystic fibrosis.
The occurrence of increased serum concentrations of pancreatic tumor markers CA 19-9, CA 50 and elastase 1 in cystic fibrosis (CF) prompted us to investigate the pancreatic markers DU-PAN-2 and TATI. DU-PAN-2 was measured in serum samples of 48 CF patients, 42 pediatric control patients, and 51 parents of CF children by a competition radioimmunoassay (RIA). A commercially available RIA test kit was used to measure TATI serum levels of 38 CF patients and 40 control patients. Nineteen percent of CF patients, 0% of the control group, and 6% of the parents exceeded the DU-PAN-2 threshold value of 300 U/ml. TATI concentrations were increased (greater than 20 micrograms/L) in 24% of CF patients and in 17% of control patients. The sensitivity-specificity curve of DU-PAN-2 was similar to those of CA 50 and elastase 1 but less discriminating than that of CA 19-9. However, the sensitivity-specificity profile of CA 19-9 can only be marginally enhanced in a range of low specificity by simultaneously determining elastase 1 and/or DU-PAN-2 antigens. TATI does not provide any diagnostic use in CF.
Scheuring
U
U
Institute of Immunobiology, University of Cologne, Federal Republic of Germany.
Skopnik
H
H
Roth
B
B
Uhlenbruck
G
G
Metzgar
R S
RS
D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D002648:Child; D003550:Cystic Fibrosis / Q000097:blood* / Q000276:immunology; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000276:immunology*; D010179:Pancreas / Q000276:immunology*; D010196:Pancreatic Elastase / Q000097:blood; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014361:Trypsin Inhibitors / Q000097:blood*
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D015415:Biomarkers; C042317:DU-PAN-2 antigen, human; D007983:Lewis Blood Group Antigens; D014361:Trypsin Inhibitors; D010196:Pancreatic Elastase