[Long-term antihypertensive treatment in diabetes mellitus. Results with the calcium antagonist felodipine].
In 17 hypertensive, insulin-treated diabetics (eight type 1 diabetics, nine type 2 diabetics) the effectiveness of 10 mg/day felodipine was investigated over a period of one year. In both groups, felodipine brought about a lasting decrease in blood pressure (p less than 0.05). After four weeks' treatment, type 1 diabetics experienced a 143% increase in albumin excretion, and an 83% increase in fractional albuminuria, as compared with the initial values (p less than 0.05). In type 2 diabetics, in contrast, albumin excretion decreased by 25%, fractional albuminuria by 48% (p less than 0.05; p less than 0.01, as compared with type 1 diabetics). After 28 weeks of treatment, the fractionale albuminuria in the two groups had decreased by 27% (p less than 0.05 compared with the short-term response) and 37%, respectively. No change in hormone or metabolic parameters was observed.
Jungmann
E
E
Abteilung für Endokrinologie, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main.
Schumm-Draeger
P M
PM
Nickelsen
T
T
Scheuermann
E H
EH
Schöffling
K
K
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D015736:Felodipine / Q000008:administration & dosage*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged
D015736:Felodipine
Antihypertensive Langzeitbehandlung bei Diabetes mellitus. Ergebnisse mit dem Kalziumantagonisten Felodipin.