title: [Experimental hepatitis E infection in piglets].
abstract: A sample of patient's faeces containing virus-like particles (VLP) of 27-34 nm was obtained during an outbreak of hepatitis E in the Kirghiz SSR. The identity of the VLP to hepatitis E virus and etiological association with the disease were demonstrated by immune electron microscopy and infection of Macaca fascicularis monkeys. This isolate of hepatitis E virus is able to induce experimental infection in domestic piglets which was very similar to experimental hepatitis E in primates when infected orally, intravenously and by the combined routes. The clinical manifestations included acute biochemical and histological hepatitis, excretion of hepatitis E virus in faeces, icteric sclerae and skin, hepatitis virus presence in the material from mesenteric lymph nodes. Immunosuppression aggravated hepatitis E infection in piglets. Piglet-to-piglet transmission of hepatitis E virus was demonstrated. During passages of the virus in piglets a shortening of the incubation period and the absence of jaundice was observed.
authors.forename: R K
authors.initials: RK
authors.lastname: Usmanov
authors.forename: M S
authors.initials: MS
authors.lastname: Balaian
authors.forename: D I
authors.initials: DI
authors.lastname: Dzhumalieva
authors.forename: D B
authors.initials: DB
authors.lastname: Alymbaeva
authors.forename: M B
authors.initials: MB
authors.lastname: Korolev
authors.forename: F R
authors.initials: FR
authors.lastname: Karas'
authors.forename: N A
authors.initials: NA
authors.lastname: Zamiatina
authors.forename: S K
authors.initials: SK
authors.lastname: Berdikozhoeva
authors.forename: Ch T
authors.initials: ChT
authors.lastname: Karymshakova
authors.forename: E T
authors.initials: ET
authors.lastname: Kozhomkulov
mesh_terms: D000818:Animals; D005243:Feces / Q000382:microbiology; D006508:Hepatitis Antibodies / Q000097:blood; D006518:Hepatitis Viruses / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D006524:Hepatitis, Viral, Animal / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000382:microbiology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008252:Macaca fascicularis; D013552:Swine; D013553:Swine Diseases / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology
chemical_list: D006508:Hepatitis Antibodies
vernacular_title: Eksperimental'naia infektsiia gepatita E u porosiat.