title: Oral administration of 24,25(OH)2D3 suppresses the serum parathyroid hormone levels of dialysis patients.
abstract: We measured the serum parathyroid hormone (PTH) levels in 20 patients treated with continuous ambulatory peritoneal dialysis before and after oral treatment with 24,25-dihydroxyvitamin D3- 24,25(OH)2D3. This metabolite was given in addition to existing treatment with 1 alpha-OH-D3 and calcium carbonate. Administration of 24,25(OH)2D3 led to a significant decrease in PTH levels (intact molecule) from 382 +/- (SE) 65 to 245 +/- 54 pg/ml in 9 patients whose initial levels were extremely high (p = 0.01). No side effects were observed. On the average, calcium values were unchanged and within the normal range throughout the study period; however, a few episodes of mild asymptomatic hypercalcemia occurred which responded quickly to reduction of the calcium carbonate dosage. The present study suggests that oral administration of 24,25(OH)2D3 combined with 1 alpha-OH-D3 is safe and capable of suppressing the raised serum PTH levels of end-stage renal disease patients without the danger of significant hypercalcemia.
authors.affiliation: Department of Pediatrics A, Ben-Gurion University of the Negev, Beersheba, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Ben-Ezer
authors.forename: S
authors.initials: S
authors.lastname: Shany
authors.forename: A
authors.initials: A
authors.lastname: Conforty
authors.forename: J
authors.initials: J
authors.lastname: Rapoport
authors.forename: S
authors.initials: S
authors.lastname: Edelstein
authors.forename: T
authors.initials: T
authors.lastname: Bdolah-Abram
authors.forename: D R
authors.initials: DR
authors.lastname: Kafka
authors.forename: C
authors.initials: C
authors.lastname: Chaimovitz
mesh_terms: D015650:24,25-Dihydroxyvitamin D 3 / Q000008:administration & dosage* / Q000494:pharmacology; D000284:Administration, Oral; D000368:Aged; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010531:Peritoneal Dialysis, Continuous Ambulatory
chemical_list: D010281:Parathyroid Hormone; D015650:24,25-Dihydroxyvitamin D 3; D002119:Calcium Carbonate