[Possibilities for optimization of radiotherapy of esophageal carcinoma through measurement of the oncoradiogenic enzyme peak of glucosephosphate isomerase].
In 20 patients with oesophageal carcinoma blood samples were taken after the first irradiation and the activity of the glycolytic enzyme glucose-6-phosphate isomerase was measured. In all patients there occur GPI peaks at reproducible times. The height of the enzyme peak occurring 15.5 to 19.5 hours p.irr. expresses a significant dependence on tumour size and irradiation dose. The frequency of a late occurring enzyme peak depends on the appearance of regional lymph node metastases. Possible sources of the enzyme peaks are discussed from a radiobiological point of view and the meaning of such enzyme peaks for the optimization of radiation therapy is pointed out.
Tunak
D
D
Klinik und Poliklinik für Onkologie, Bereich Medizin (Charité), Humboldt-Universität Berlin, Bundesrepublik Deutschland.
Below
M
M
Dallüge
K H
KH
Henkel
P
P
Nicolai
T
T
Kuchenbecker
F
F
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000532:radiotherapy*; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000532:radiotherapy*; D005260:Female; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010347:Patient Care Planning; D010953:Plasma Volume; D011879:Radiotherapy Dosage; D013997:Time Factors
D005956:Glucose-6-Phosphate Isomerase
Möglichkeiten der Optimierung der Strahlentherapie von Oesophaguskarzinomen durch die Messung des onkoradiogenen Enzympeaks der GPI.