[Role of estrogens in the regulation of composition of bile acids of the enterohepatic system in rats and monkeys with extrahepatic cholestasis].
Analysis of the thin-layer chromatography and gas chromatography data on the free and conjugated bile acid contents in the blood leaving intestine, hepatocytes and bile of ovariectomized rabbits and monkeys with acalculous cholecystitis revealed a heterogeneity of bile acid distribution in these biological media and an uniformity of specific alterations manifested in increased glyco-conjugation, decreased free bile acids in hepatocytes and blood, decreased cholesterol level and reduced lithogenic index of the bile. Results obtained are indicative of involvement of the gonadal steroids and estradiol dipropionate in regulation of bile acid conjugation in liver and, therefore, in development of one of the early factors of the gallstone formation.
Bogdarin
Iu A
IuA
Goncharov
N P
NP
D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis*; D002764:Cholecystitis / Q000378:metabolism; D002769:Cholelithiasis / Q000209:etiology; D001651:Cholestasis, Extrahepatic / Q000378:metabolism*; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004764:Enterohepatic Circulation; D004967:Estrogens / Q000502:physiology*; D005260:Female; D008251:Macaca; D010052:Ovariectomy; D011817:Rabbits
D001647:Bile Acids and Salts; D004967:Estrogens
Uchastie éstrogenov v reguliatsii sostava zhelchnykh kislot énterogepaticheskoĭ sistemy krolikov i obez'ian s vnepechenochnym kholestazom.