title: Influence of lysine acetyl-salicylate on glucose and arginine stimulated insulin release in man.
abstract: In order to determine the influence of acute inhibition of prostaglandin synthesis on insulin release in man, the influence of lysine acetyl-salicylate (0.9 g) on glucose- and arginine-stimulated insulin release was studied in eight volunteers. No significant differences were found in plasma C-peptide levels between the salicylate and the control study days during administration of arginine (0.5 g/kg; 30 min) nor during a hyperglycemic clamp (glucose level 17 mMol/L; 60 minutes). These studies indicate that acute administration of salicylate does not change insulin release in man.
authors.affiliation: Dept. of Endocrinology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: T W
authors.initials: TW
authors.lastname: van Haeften
authors.forename: T F
authors.initials: TF
authors.lastname: Veneman
authors.forename: E A
authors.initials: EA
authors.lastname: van der Veen
mesh_terms: D000328:Adult; D001120:Arginine / Q000494:pharmacology*; D001241:Aspirin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D001120:Arginine; D005947:Glucose; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate