title: Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog.
abstract: To investigate the possible hemodynamic effects of interleukin-6 (IL-6), a single dose of 15 mcg/kg of recombinant IL-6 isolated from Escherichia coli was injected intravenously in six pentobarbital-anesthetized dogs. After 30 min, saline infusion was performed to maintain the pulmonary artery balloon-occluded pressure at baseline level. The animals were observed for up to 5 hours. No other hemodynamic alteration was observed than a gradual decline in cardiac output attributed to anesthesia. Hematologic variables, blood glucose, and total serum proteins were also constant. IL-6 levels were markedly elevated in the blood, but no tumor necrosis factor activity was detected. Thus a primary role for IL-6 in the early cardiovascular alterations associated with septic shock seems unlikely.
authors.affiliation: Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium.
authors.forename: J C
authors.initials: JC
authors.lastname: Preiser
authors.forename: D
authors.initials: D
authors.lastname: Schmartz
authors.forename: P
authors.initials: P
authors.lastname: Van der Linden
authors.forename: J
authors.initials: J
authors.lastname: Content
authors.forename: P
authors.initials: P
authors.lastname: Vanden Bussche
authors.forename: W
authors.initials: W
authors.lastname: Buurman
authors.forename: W
authors.initials: W
authors.lastname: Sebald
authors.forename: E
authors.initials: E
authors.lastname: Dupont
authors.forename: M R
authors.initials: MR
authors.lastname: Pinsky
authors.forename: J L
authors.initials: JL
authors.lastname: Vincent
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects*; D006454:Hemoglobins / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D011994:Recombinant Proteins / Q000097:blood / Q000494:pharmacology; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D006454:Hemoglobins; D015850:Interleukin-6; D011994:Recombinant Proteins; D010100:Oxygen