Influence of aging on the acute depletion of reduced glutathione induced by electrophilic agents.
A severe age-dependent depletion of reduced glutathione (GSH) occurs in rat forebrain at 1-3 h from intraperitoneal injection of the electrophilic agents cyclohexene-1-one and cycloheptene-1-one. Chronic pretreatment with central dopamine agonists (i.e., ergot alkaloids; particularly, dihydroergocriptine) partially counteracts the GSH depletion induced in 15-month-old forebrains by the prooxidants tested. In contrast, chronic pretreatment with a vasodilator agent (i.e., papaverine) magnifies the GSH depletion.
Benzi
G
G
Institute of Pharmacology, University of Pavia, Italy.
Pastoris
O
O
Gorini
A
A
Marzatico
F
F
Villa
R F
RF
Curti
D
D
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003508:Cycloheptanes / Q000008:administration & dosage / Q000494:pharmacology; D003512:Cyclohexanones / Q000008:administration & dosage / Q000494:pharmacology; D004088:Dihydroergotoxine / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D010208:Papaverine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D003508:Cycloheptanes; D003512:Cyclohexanones; D004088:Dihydroergotoxine; C025378:cyclohept-2-en-1-one; C028215:2-cyclohexen-1-one; D010208:Papaverine; D005978:Glutathione