[Atherogenic effect of beta-blocker propranolol revealed in the rabbit denudated aorta].
The influence of beta-blocker propranolol onto atherogenic properties of blood serum and to formation of myointimal thickening in rabbit aorta, which was caused by denudation, were investigated. The preparation was introduced per os in the dose 6 mg/kg. Culture of mouse peritoneal macrophages was used to estimate the atherogenic properties of the serum. Serum of propranolol-treated rabbits induced accumulation of cholesterol in cultivated cells. Propranolol also induced an increase of the thickness of aortic intima, lipid accumulation and increasing of cell's number in myointimal thickening. Thus, atherogenic effect of beta-blocker propranolol was found both in vitro and in vivo.
Andrianova
I V
IV
Rekhter
M D
MD
Tertov
V V
VV
Andreeva
E R
ER
Ragimov
S E
SE
Mironov
A A
AA
Orekhov
A N
AN
D000284:Administration, Oral; D000818:Animals; D001011:Aorta / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D001161:Arteriosclerosis / Q000139:chemically induced*; D002478:Cells, Cultured; D002784:Cholesterol / Q000097:blood; D008055:Lipids / Q000032:analysis / Q000097:blood; D008264:Macrophages; D008297:Male; D051379:Mice; D011433:Propranolol / Q000008:administration & dosage / Q000009:adverse effects*; D011817:Rabbits
D008055:Lipids; D002784:Cholesterol; D011433:Propranolol
Aterogennyĭ éffekt beta-blokatora propranolola, vyiavlennyĭ na deéndotelizirovannoĭ aorte krolikov.