title: Dipyridamole potentiates the anti-aggregating and vasodilator activity of nitric oxide.
abstract: The interaction between dipyridamole and nitric oxide (NO) was studied using isolated rabbit platelets and segments of the rabbit aorta. Dipyridamole potentiated the anti-aggregating activity of authentic NO when platelet aggregation was induced by the thromboxane A2 mimetic U-46619 or adenosine diphosphate (ADP). This potentiation was also seen when washed rabbit platelets were exposed to aortic effluent containing endothelium-derived NO. In the thoracic aorta dipyridamole hardly influenced the endothelium-dependent relaxations induced by acetylcholine. However, dipyridamole clearly enhanced the dilatation caused by exogenous NO from four different sources, including endothelial cells.
authors.affiliation: University of Antwerp (UIA), Division of Pharmacology, Wilrijk, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Bult
authors.forename: H R
authors.initials: HR
authors.lastname: Fret
authors.forename: F H
authors.initials: FH
authors.lastname: Jordaens
authors.forename: A G
authors.initials: AG
authors.lastname: Herman
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000109:Acetylcholine / Q000494:pharmacology; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D004176:Dipyridamole / Q000494:pharmacology*; D004357:Drug Synergism; D011464:Epoprostenol / Q000494:pharmacology; D066298:In Vitro Techniques; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009569:Nitric Oxide / Q000378:metabolism / Q000494:pharmacology*; D005996:Nitroglycerin / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology; D011817:Rabbits; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D010975:Platelet Aggregation Inhibitors; D011450:Prostaglandin Endoperoxides, Synthetic; D010656:Phenylephrine; D009569:Nitric Oxide; D000244:Adenosine Diphosphate; D004176:Dipyridamole; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D011464:Epoprostenol; D005996:Nitroglycerin; D000109:Acetylcholine