title: Tissue plasminogen activator and other risk factors as predictors of cardiovascular events in patients with severe angina pectoris.
abstract: The value of measurements of the fibrinolytic factors, tissue plasminogen activator and plasminogen activator inhibitor, for predicting death and non-fatal cardiovascular events was studied in 213 consecutive patients with angiographically documented coronary artery disease. In the course of 4-year follow-up, 47 patients (22.1%) had at least one cardiovascular event. We found the incidence of cardiovascular events to be positively associated with high tissue plasminogen activator antigen concentration, in addition to previous myocardial infarction, low ejection fraction, hypertension, high body mass index and high triglyceride levels. Cholesterol was not found to be associated with cardiovascular events. A high concentration of tissue plasminogen activator antigen thus implies an increased risk of cardiovascular events in patients with severe angina pectoris.
authors.affiliation: Department of Internal Medicine, Skellefteå Hospital, Sweden.
authors.forename: J H
authors.initials: JH
authors.lastname: Jansson
authors.forename: T K
authors.initials: TK
authors.lastname: Nilsson
authors.forename: B O
authors.initials: BO
authors.lastname: Olofsson
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000097:blood*; D002423:Cause of Death; D002561:Cerebrovascular Disorders / Q000401:mortality; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000097:blood / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000401:mortality; D015849:Plasminogen Inactivators / Q000097:blood*; D012307:Risk Factors; D010959:Tissue Plasminogen Activator / Q000097:blood*
chemical_list: D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator