To wall off neoplasms with more viscous extracellular matrix.
Normal inflammatory and immune mechanisms would destroy most neoplasms if the neoplasm did not alter its immediate environment to weaken the host defenses. Based on factors that seem to increase extracellular matrix viscosity, methods of enhancing host resistance in the vicinity of the tumor are suggested by the author. This includes adjuvant therapy, pyridoxine antagonist, cytokines, beta carotene, retinoids, vitamin C, iodides, bromides, and pellagragenic substances. Hyperthermia may also have an effect.
Stone
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OJ
D000818:Animals; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D006979:Hyperthermia, Induced; D007249:Inflammation / Q000503:physiopathology; D008954:Models, Biological; D009369:Neoplasms / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D014783:Viscosity