title: [Selective inhibition of monoamine oxidase in bovine brain by befol and moclobemide].
abstract: Effects of befol and moklobemide on thyramine-, serotonin- and 2-phenyl ethylamine deaminase activities of mitochondrial monoamine oxidase from bovine truncus cerebri were studied. These drugs are reversible noncompetitive inhibitors of the enzyme not requiring preincubation. They inhibited most effectively the serotonin deaminase activity as compared with phenyl ethylamine deaminase activity, however they should not be concerned with typical inhibitors of monoamine oxidases of the A type as inhibition of thyramine deaminase activity was not found.
authors.forename: T A
authors.initials: TA
authors.lastname: Moskvitina
authors.forename: E M
authors.initials: EM
authors.lastname: Gankina
authors.forename: A V
authors.initials: AV
authors.lastname: Val'dman
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002417:Cattle; D008928:Mitochondria / Q000187:drug effects; D006899:Mixed Function Oxygenases / Q000378:metabolism; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors; D009025:Morpholines / Q000494:pharmacology*; D013379:Substrate Specificity
chemical_list: D000928:Antidepressive Agents; D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D009025:Morpholines; C059049:befol; D006899:Mixed Function Oxygenases; D020912:Moclobemide
vernacular_title: Ob izbiratel'nosti tormozheniia monoaksidazy mozga byka befolom i moklobemidom.