[Ocular histopathology and ultrastructure in mucopolysaccharidosis-I].
The ocular histopathology of type I mucopolysaccharidosis was studied with histochemical, ultrahistochemical, and ultrastructural techniques. The latter method showed extensive intracellular accumulation of fibrillogranular vacuoles in virtually every ocular tissue. Ultra-histochemistry proved that the fibrillogranular material was acid mucopolysaccharide. The pathologic mechanism of scleral thickening, retinal pigment epithelial degeneration, and glaucoma were discussed.
Li
Y P
YP
Zhongshan Ophthalmic Centre, Sun Yat-sen University of Medical Sciences, Guangzhou.
D000293:Adolescent; D005123:Eye / Q000473:pathology / Q000648:ultrastructure*; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008059:Mucopolysaccharidosis I / Q000378:metabolism / Q000473:pathology*