Nuclear oncogenes.
Ample evidence has accumulated in recent years to establish that most, if not all, nuclear proto-oncogenes are in fact sequence-specific DNA-binding proteins that modulate gene expression. Their synthesis or activity is modulated by extracellular signals or by cross talk between different classes of transcription factors.
Ghysdael
J
J
Section de Biologie, Institut Curie, Centre Universitaire, Orsay, France.
Yaniv
M
M
D000818:Animals; D001483:Base Sequence; D002467:Cell Nucleus / Q000502:physiology*; D009841:Oligonucleotides / Q000378:metabolism; D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D014157:Transcription Factors / Q000378:metabolism
D009841:Oligonucleotides; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D011505:Protein-Tyrosine Kinases