Disturbance of nuclear transport of proteins in CD4+ cells expressing gp160 of human immunodeficiency virus.
An extensive cytopathic effect occurred in the CD4+ cells expressing gp160 of human immunodeficiency virus. A protein capable of nuclear location that was microinjected into such cells was not transported into the nuclei at an early stage when little cytopathic effect had yet to occur.
Koga
Y
Y
Department of Immunology, Kyushu University, Fukuoka, Japan.
Sasaki
M
M
Yoshida
H
H
Oh-Tsu
M
M
Kimura
G
G
Nomoto
K
K
D000595:Amino Acid Sequence; D015704:CD4 Antigens / Q000502:physiology*; D002104:Cadmium / Q000494:pharmacology; D019256:Cadmium Chloride; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D015686:Gene Products, env / Q000235:genetics* / Q000378:metabolism; D005814:Genes, Viral; D006678:HIV / Q000235:genetics* / Q000502:physiology; D019302:HIV Envelope Protein gp160; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000378:metabolism*; D010957:Plasmids; D011498:Protein Precursors / Q000235:genetics* / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D014162:Transfection
D015704:CD4 Antigens; D015686:Gene Products, env; D019302:HIV Envelope Protein gp160; D010455:Peptides; D011498:Protein Precursors; D002104:Cadmium; D012710:Serum Albumin, Bovine; D019256:Cadmium Chloride