title: N-acetyl-beta-D-glucosaminidase as a predictor of milk loss and recovery after clinical mastitis.
abstract: Milk samples were collected at onset of 508 episodes of clinical mastitis on a 1,700-cow dairy farm in Michigan. Daily milk production and disease events were recorded for all cows in the herd. Despite statistical association with severity of mastitis, this association was too weak for N-acetyl-beta-D-glucosaminidase (NAGase) activity to be of great value as a prognostic test for clinical mastitis. High milk NAGase activity was significantly (P less than 0.0001) associated with: increased duration of treatment; increased duration of clinical signs of mastitis; decreased daily milk production; and increased risk of the cow being culled because of mastitis. The NAGase value was combined with days in milk production, baseline milk production before mastitis onset, parity, and season of onset to predict the outcome of clinical cases as measured by the first 3 aforementioned variables. Statistical models explained little of the variability among cows in duration of treatment (R2 = 0.11), duration of clinical signs of infection (R2 = 0.11), and milk production change (R2 = 0.09).
authors.affiliation: Quality Milk Promotion Service, New York State College of Veterinary Medicine, Cornell University, Ithaca 14850.
authors.forename: D J
authors.initials: DJ
authors.lastname: Wilson
authors.forename: P C
authors.initials: PC
authors.lastname: Bartlett
authors.forename: J H
authors.initials: JH
authors.lastname: Kirk
authors.forename: R W
authors.initials: RW
authors.lastname: Mellenberger
authors.forename: E C
authors.initials: EC
authors.lastname: Mather
mesh_terms: D000118:Acetylglucosaminidase / Q000032:analysis*; D000704:Analysis of Variance; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002417:Cattle; D005260:Female; D007774:Lactation; D008414:Mastitis, Bovine / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D008892:Milk / Q000201:enzymology* / Q000378:metabolism; D010298:Parity; D011379:Prognosis; D012044:Regression Analysis
chemical_list: D000900:Anti-Bacterial Agents; D000118:Acetylglucosaminidase