Inhibition of histamine synthesis influences the development of hypertension in spontaneously hypertensive rats.
Young (3-week old) and adult (7-week old) spontaneously hypertensive rats (SHR) and normotensive rats (WKY) were treated with alpha-fluoromethylhistidine (alpha-FMH) for 29 and 13 days, respectively. Treatment of SHR and WKY with alpha-FMH led to a pronounced decrease in the histidine decarboxylase activity and in the histamine concentration in all brain areas studied. In adult SHR, the development of hypertension was not influenced by alpha-FMH. In young SHR, alpha-FMH elicited a transient delay in the development of hypertension followed by a short-lasting tendency for increased blood pressure. It is concluded that histaminergic neurons of the brain play, if at all, only a secondary role in the development of hypertension in SHR.
Prast
H
H
Department of Pharmacodynamics and Toxicology, University of Innsbruck, Austria.
D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism; D006632:Histamine / Q000096:biosynthesis*; D006633:Histamine Antagonists / Q000494:pharmacology*; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006973:Hypertension / Q000503:physiopathology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008762:Methylhistidines / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D006633:Histamine Antagonists; D008762:Methylhistidines; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D006640:Histidine Decarboxylase