title: Glycerol injection into the trigeminal ganglion provokes a selective increase in human cerebral blood flow.
abstract: Fourteen patients suffering from idiopathic trigeminal neuralgia (refractory to medication) were treated by injection of glycerol into the trigeminal ganglion. The changes in cerebral blood flow (CBF) after glycerol injection were quantified by intravenous 133Xe emission tomography. There was a significant 11% (P less than 0.01) increase in ipsilateral CBF and an 8% (P less than 0.05) increase in contralateral CBF 1 h after glycerol injection. The interhemispheric difference was significant (P less than 0.05). The increase was significantly greater in the ipsilateral internal carotid territory, in the anterior cerebral artery and middle cerebral artery territories (superficial (P less than 0.05), deep territories (P less than 0.001]. We suggest that these changes are due to the release of substance P and/or calcitonin gene-related peptide, from terminals of the trigeminal-vascular system during glycerol injection.
authors.affiliation: Service d'Explorations Fonctionnelles du Système Nerveux., Hôpital Lariboisière, ParisFrance Laboratoire de Physiologie et Physiopathologie Cérébrovasculaire, U 182 INSERM, UA 641 CNRS, Université Paris VII, Faculté de Médecine Lariboisière-St Louis, ParisFrance Centre de Traitement de la Douleur, Hôpital Lariboisière, ParisFrance.
authors.forename: Yves Roger Tran
authors.initials: YRT
authors.lastname: Dinh
authors.forename: Claude
authors.initials: C
authors.lastname: Thurel
authors.forename: Alain
authors.initials: A
authors.lastname: Serrie
authors.forename: Gérard
authors.initials: G
authors.lastname: Cunin
authors.forename: Jacques
authors.initials: J
authors.lastname: Seylaz
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D005990:Glycerol / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon; D012668:Trigeminal Ganglion / Q000187:drug effects*; D014277:Trigeminal Neuralgia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D005990:Glycerol