title: The "plateau effect" of cis-platinum-induced hearing loss.
abstract: Cis-platinum-induced hearing loss has been reported to exhibit a "plateau effect" over the 2 to 8 kHz range. We examined serial audiometry data from 27 patients treated with cis-platinum. Although a plateau at 60 to 70 dB HL often occurred, this hearing loss was clearly exceeded in a number of patients. We identified 14 patients with sufficient cis-platinum-induced sensorineural hearing loss to evaluate a plateau limit to hearing loss over the 4 to 8 kHz range. Half of these 14 patients had hearing losses that exceeded the plateau level. More severe 4 to 8 kHz hearing losses did not correlate with number of treatments, cumulative dosages of cis-platinum, pre-existing hearing loss, radiation therapy, other chemotherapeutic agents, or even hearing losses below 4 kHz. Although cis-platinum therapy can induce a plateau of moderate hearing impairment for some patients over the 4 to 8 kHz range, a significant proportion of patients will experience more severe hearing impairment in this range, even after only one or two courses of cis-platinum.
authors.affiliation: Department of Otolaryngology, Wayne State University, Detroit, MI 48201.
authors.forename: S F
authors.initials: SF
authors.lastname: Myers
authors.forename: B W
authors.initials: BW
authors.lastname: Blakley
authors.forename: S
authors.initials: S
authors.lastname: Schwan
authors.forename: W F
authors.initials: WF
authors.lastname: Rintelmann
authors.forename: R H
authors.initials: RH
authors.lastname: Mathog
mesh_terms: D000162:Acoustics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001299:Audiometry; D002945:Cisplatin / Q000009:adverse effects*; D006312:Hearing Loss, Bilateral / Q000139:chemically induced*; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged
chemical_list: D002945:Cisplatin