title: A case of myelodysplastic syndrome with abnormal megakaryocytes and ins(8;3)(q24;q21q26).
abstract: We report a 56-year-old male patient with refractory anemia with excess of blasts in transformation (RAEB-T) who had an ins(8;3)(q24;q21q26) as the sole chromosome abnormality in bone marrow (BM) cells. The findings of disturbed thrombocytopoiesis with numerous micromegakaryocytes suggest that it could be a variant of the classic ins(3;3)(q26;q21q26) described in hematologic malignancies with abnormal thrombopoiesis.
authors.affiliation: Department of Hematology-Cytogenetics, Centre Hôpitalier, Saint Priest en Juarez, France.
authors.forename: M
authors.initials: M
authors.lastname: Bachy-Delhomme
authors.forename: M F
authors.initials: MF
authors.lastname: Bertheas
authors.forename: J
authors.initials: J
authors.lastname: Jaubert
authors.forename: P
authors.initials: P
authors.lastname: Calmard
authors.forename: C
authors.initials: C
authors.lastname: Vasselon
authors.forename: J
authors.initials: J
authors.lastname: Reynaud
authors.forename: C P
authors.initials: CP
authors.lastname: Brizard
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology