Lack of effect of flosequinan on the pharmacokinetics of theophylline.
The pharmacokinetics of theophylline (240 mg) p.o. were studied before and after the administration of oral flosequinan for 14 days in 21 healthy volunteers using a randomised cross-over design. Comparisons of Cmax, tmax, AUC, CL of theophylline and urinary recovery of the parent drug and metabolites showed that flosequinan had no significant effect on the disposition of theophylline.
Kamali
F
F
Wolfson Unit of Clinical Pharmacology, The University, Newcastle upon Tyne.
Edwards
C
C
Rawlins
M D
MD
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D011804:Quinolines / Q000494:pharmacology*; D011897:Random Allocation; D013806:Theophylline / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D014665:Vasodilator Agents / Q000494:pharmacology*
D011804:Quinolines; D014665:Vasodilator Agents; C047316:flosequinan; D013806:Theophylline