title: Infectious crystalline keratopathy occurring in an eye subsequent to glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil.
abstract: We present a case of infectious crystalline keratopathy occurring after 5-fluorouracil filtering surgery. The patient had discrete, branching, white crystalline lesions in the anterior corneal stroma. Cultures grew Streptococcus viridans, and gram-positive cocci were demonstrated in corneal tissue biopsy specimens. Toxic and immunosuppressive properties of 5-fluorouracil may have participated in the pathogenesis of the infectious crystalline keratitis.
authors.affiliation: Department of Ophthalmology, Cleveland Clinic Foundation, OH 44195-5024.
authors.forename: C
authors.initials: C
authors.lastname: Patitsas
authors.forename: E J
authors.initials: EJ
authors.lastname: Rockwood
authors.forename: D M
authors.initials: DM
authors.lastname: Meisler
authors.forename: J T
authors.initials: JT
authors.lastname: McMahon
mesh_terms: D002908:Chronic Disease; D015818:Eye Infections, Bacterial / Q000209:etiology*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D015812:Glaucoma, Angle-Closure / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007634:Keratitis / Q000209:etiology*; D008875:Middle Aged; D013290:Streptococcal Infections / Q000209:etiology*; D014130:Trabeculectomy
chemical_list: D005472:Fluorouracil