title: Origin of malignant centrofacial granulomas: surface markers and gene rearrangement of malignant cells.
abstract: Malignant centrofacial granuloma (MCFG) is a clinical entity characterized by a relentless ulceration of the upper airway involving the nose, palate, and face, without any demonstrable etiology. The origin of 11 cases were analyzed with the help of cell-surface immunostaining in all and with T-cell receptor gene (TCR) rearrangement in 3. The results show that most of the cases of MCFG are in fact T-cell lymphomas with cell-surface antigens (CD2, CD7, CD3) consistent with either early or mature T lymphocytes. However, some cases exhibit B-lymphoid (CD19, CD20) or histiomonocytic (CD13, CD14) lineage-specific markers. In conclusion, despite its remarkable clinical unity, MCFG is a heterogeneous group of neoplastic diseases, most but not all of which may be classified as T-cell lymphoma.
authors.affiliation: Department of Internal Medicine, Saint-Antoine Hospital, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Cabane
authors.forename: M
authors.initials: M
authors.lastname: Raphaël
authors.forename: G
authors.initials: G
authors.lastname: Lamas
authors.forename: D
authors.initials: D
authors.lastname: Mossalayi
authors.forename: A
authors.initials: A
authors.lastname: Dubois
authors.forename: G
authors.initials: G
authors.lastname: Chomette
authors.forename: P
authors.initials: P
authors.lastname: Godeau
authors.forename: C
authors.initials: C
authors.lastname: Marty-Double
authors.forename: J F
authors.initials: JF
authors.lastname: Rossi
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D002454:Cell Differentiation; D015321:Gene Rearrangement; D006103:Granuloma, Lethal Midline / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016399:Lymphoma, T-Cell / Q000145:classification; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000954:Antigens, Surface