EEG mapping in mentally retarded children by synthetic arginine vasotocin administration.
EEG investigations (using source-derivation) were performed in 15 mentally retarded children, before, during (at 1 and 6 months) and after three months of pineal hormone treatment (AVT, 10(-6) mg/day, intranasally). Power spectral analysis, maturation lines and EEG mapping were used to ascertain the functional changes induced by AVT. A rapid increase in maturation EEG coefficients was found. It resulted from a significant reduction in the percent amount of theta and delta activity and from the increase in alpha activity. A significant increase in alpha peak frequency occurred after 6 months of treatment as well as a better separation of the EEG patterns between the anterior and posterior halves of the hemispheres. These favourable effects were clearly evidenced by EEG mapping. They are in good relation with cognitive function (attention, intelligence) improvement induced by AVT therapy.
Psatta
D M
DM
Institute of Neurology and Psychiatry, Bucharest, Romania.
Goldstein
R
R
Matei
M
M
D000281:Administration, Intranasal; D001127:Arginine Vasopressin / Q000008:administration & dosage*; D001931:Brain Mapping / Q000379:methods*; D002648:Child; D004341:Drug Evaluation; D004569:Electroencephalography / Q000187:drug effects* / Q000379:methods; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D013997:Time Factors
D001127:Arginine Vasopressin