title: Cancer dormancy: studies of the murine BCL1 lymphoma.
abstract: Dormancy in the murine BCL1 lymphoma can be induced by several strategies including cytoreductive therapy of mice with large tumor burdens and challenge of allogeneic chimeric mice or idiotype-immunized mice with BCL1 tumor. Dormant tumor cells were isolated from the spleens of the chimeric mice and the majority were shown to be noncycling. In idiotype-immunized mice that had lost dormancy, tumor growth occurred at a relatively rapid rate. A proportion of idiotype-immunized mice that had lost dormancy spontaneously regressed and then again relapsed; in these mice, the serum antiidiotypic levels were inversely related to the tumor burden.
authors.affiliation: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.
authors.forename: J W
authors.initials: JW
authors.lastname: Uhr
authors.forename: T
authors.initials: T
authors.lastname: Tucker
authors.forename: R D
authors.initials: RD
authors.lastname: May
authors.forename: H
authors.initials: H
authors.lastname: Siu
authors.forename: E S
authors.initials: ES
authors.lastname: Vitetta
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002453:Cell Cycle / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D005260:Female; D007114:Immunization; D007130:Immunoglobulin Idiotypes / Q000276:immunology / Q000627:therapeutic use; D007075:Immunoglobulin M / Q000627:therapeutic use; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011828:Radiation Chimera / Q000276:immunology; D012074:Remission Induction; D013601:T-Lymphocytes / Q000502:physiology; D014407:Tumor Cells, Cultured
chemical_list: D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M