Assessment of the drug inhibitor specificity of the human liver 4-methylumbelliferone UDP-glucuronosyltransferase activity.
The data suggest that the 4MU-UDPGT activity of human liver microsomes probably contributes to the glucuronidation of a limited number of clinically used drugs. However, confirmation of this ultimately requires studies to be performed with purified isozymes, cDNAs expressed in cell culture, or specific inhibitory antibodies.
Miners
J O
JO
Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, Adelaide, Australia.
Lillywhite
K J
KJ
D004790:Enzyme Induction; D005279:Fenoprofen / Q000494:pharmacology; D014453:Glucuronosyltransferase / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D006801:Humans; D006923:Hymecromone / Q000378:metabolism*; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010076:Oxazepam / Q000494:pharmacology; D012459:Salicylates / Q000494:pharmacology; D020156:Salicylic Acid; D013379:Substrate Specificity; D013693:Temazepam / Q000494:pharmacology
D007527:Isoenzymes; D012459:Salicylates; D006923:Hymecromone; D010076:Oxazepam; D013693:Temazepam; D014453:Glucuronosyltransferase; D020156:Salicylic Acid; D005279:Fenoprofen