Anti-inflammatory and immunomodulating effects of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone. 2nd communication: inhibitory effect on rat adjuvant induced disease.
The effect of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone (gamma-ABT) on local and systemic changes of rats with adjuvant induced disease (AID) was investigated, gamma-ABT showed potent inhibitory effect on adjuvant primary inflammation and almost totally inhibited the secondary lesions. gamma-ABT improved the changes in lymphoid organ weight except of the thymus. gamma-ABT improved the change in albumin/globulin ratio, which is a parameter of systemic inflammatory reaction but did not improve the body weight gain in AID and normal rats. In addition gamma-ABT did not affect directly T or B lymphocytes as shown by the lymphocyte responses to mitogen (Con A) and a T cell dependent antigen (SRBC) but rather inhibited the suppressor cells found in AID. Although structurally gamma-ABT is completely different from known non-steroidal anti-inflammatories, immunosuppressive drugs behave to a great extent like them.
Kourounakis
L
L
Department of Genetics, School of Biology, Faculty of Sciences, Aristotelian University, Thessaloniki, Greece.
Gavalas
A
A
Karagouni
E E
EE
Litina
D
D
Kourounakis
P
P
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D001402:B-Lymphocytes / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D005528:Foot / Q000473:pathology; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008934:Mitogens; D009161:Mycobacterium; D051381:Rats; D011916:Rats, Inbred F344; D013601:T-Lymphocytes / Q000187:drug effects; D013876:Thiophenes / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008112:Liver Glycogen; D008934:Mitogens; D013876:Thiophenes; D003208:Concanavalin A; C070063:gamma-(2-aminoethylamino)-2-butryothienone