[Mechanisms of the effect of allopurinol on the metabolism of adenine nucleotides].
The effect of repeated administration of allopurinol (50 mg.kg-1 48, 24, and 4 hours before analysis) on the activity of enzymes of degradation and resynthesis of adenine nucleotides was studied. The activity of xanthine dehydrogenase and xanthine oxidase was inhibited in the heart, liver and kidney and the activity of membrane-bound 5'-nucleotidase was particularly elevated in the heart and brain, suggesting that membrane transport processes may be affected. The increase in the activity of hypoxanthine guanine phosphoribosyl transferase in the liver is indicative of a potential mechanism of positive action of allopurinol upon restoring the purine nucleotide store. The authors present their hypothesis on the mechanism of allopurinol action upon the metabolism of adenine nucleotides. The suggested mechanisms might become operative in protecting tissues against ischemia and reperfusion induced damage.
Pechán
I
I
Ustav kardiovaskulárnych chorôb, Bratislave.
Cornák
V
V
Rendeková
V
V
Mrázová
J
J
Zimmer
H G
HG
D000227:Adenine Nucleotides / Q000378:metabolism*; D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014968:Xanthine Dehydrogenase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
D000227:Adenine Nucleotides; D000493:Allopurinol; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase
Mechanizmy pôsobenia alopurinolu na metabolizmus adenínových nukleotidov.