Pathologic analysis of photothermal and photomechanical effects of laser-tissue interactions.
Pathologic analysis of the biologic effects and mechanisms of laser-tissue interactions requires correlation of the irradiation parameters with the biologic status and response of the target tissues over time. The photobiologic mechanisms of laser-induced tissue injury can be separated into three categories, photochemical, photothermal and photomechanical. Anatomic pathologic analysis of laser-induced lesions reveals alterations that represent either specific markers of the photobiologic mechanism or non-specific reactions to tissue injury. Repair, regeneration and wound healing of laser induced lesions appear to be non-specific responses to the type of tissue damage rather than the photobiologic mechanism producing the lesion.
Thomsen
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Laser Biology Research Laboratory, U. Texas M.D. Anderson Cancer Center, Houston 77030.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D006358:Hot Temperature; D006801:Humans; D053685:Laser Therapy; D007834:Lasers / Q000009:adverse effects; D008027:Light