title: Semi-synthetic approaches to novel penicillins.
abstract: The first part of this account of the discovery of penicillin, published in last month's issue of TIBS, concluded with the detection of 6-beta-amino-penicillanic acid (6-APA), the nucleus of the penicillin structure. The exploitation of 6-APA led to the preparation of a range of clinically important semi-synthetic penicillins, which is described in this article.
authors.forename: J H
authors.initials: JH
authors.lastname: Nayler
mesh_terms: D010406:Penicillins / Q000138:chemical synthesis*
chemical_list: D010406:Penicillins