[The effect of irradiation on the growth of human laryngeal tumors transplanted under the kidney capsule of immunocompetent mice].
A study was made of the influence of gamma-radiation on the growth of human larynx squamous cell carcinoma transplanted under the capsule of the kidney of immunocompetent mice. The transplants were shown to increase in size 6 days after transplantation. Irradiation of animals 24 h after transplantation inhibited considerably the tumor growth. However, the preirradiation (24 h before operation) inhibited the growth of nonirradiated transplants to the same extent as the exposure of mice with the transplanted tumor fragments did: the radiation dose that induced 50% inhibition of the growth was 4.5 Gy and 5.3 Gy, respectively. Preliminary data indicate that tumor fragment of patients with the unfavourable prognosis increase in size and respond to radiation to a lesser extent.
Saenko
A S
AS
Semenets
T N
TN
Semina
O V
OV
Zamulaeva
I A
IA
Andreev
V G
VG
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D008297:Male; D051379:Mice; D011867:Radioisotope Teletherapy; D013370:Subrenal Capsule Assay
D003037:Cobalt Radioisotopes
Vliianie oblucheniia na rost transplantatov opukholeĭ gortani cheloveka pod kapsuloĭ pochek immunokompetentnykh mysheĭ.