The effect of ranitidine, cimetidine or famotidine on low-dose post-prandial alcohol absorption.
Plasma alcohol concentration following oral ingestion of 0.3 g/kg of alcohol (ethyl alcohol), one hour after an evening meal, was measured in four groups of 12 healthy subjects. Each group had a control study and a repeat study after 7 days dosing with either placebo or an H2-receptor antagonist (300 mg ranitidine nocte, 800 mg cimetidine nocte, or 40 mg famotidine nocte). There was no significant difference between the control and post-dosing studies in the integrated 4-h plasma alcohol concentration, peak plasma alcohol concentration, or time to reach peak alcohol concentration. This study shows that post-prandial alcohol absorption after 0.3 g/kg of alcohol is not affected by ranitidine, cimetidine or famotidine.
Fraser
A G
AG
University Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
Prewett
E J
EJ
Hudson
M
M
Sawyerr
A M
AM
Rosalki
S B
SB
Pounder
R E
RE
D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004435:Eating; D000431:Ethanol / Q000097:blood / Q000378:metabolism*; D015738:Famotidine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D011899:Ranitidine / Q000008:administration & dosage / Q000494:pharmacology*
D000431:Ethanol; D015738:Famotidine; D002927:Cimetidine; D011899:Ranitidine