[Polymer-metal complexes of the Mycobacterium protein antigen prevent the dissemination of postvaccinal infection in the T-deficiency state].
Primary obtained triple highly immunogenetic complex consists of nonimmunogenic protein antigen, isolated from the BCG, nontoxic polyelectrolyte and bivalent cuprum ions. Immunization with this complex provides high immunoprotection in the experimented B mice (T-deficit mice) from lethal dissemination BCG. Inoculation of single components of the complex has no protection. Result of these experiments suggest that antigen-polyelectrolyte complexes obtained on the basis of nonimmunogenic protein fraction of the tuberculosis bacilli show the properties of a thymus-independent immunization preparations, and provide immune defense in the T-cell deficit of the immune system.
Norimov
A Sh
ASh
Mustafaev
M I
MI
Romanova
R Iu
RIu
Abramenko
T V
TV
D000818:Animals; D000942:Antigens, Bacterial / Q000302:isolation & purification / Q000627:therapeutic use*; D001500:BCG Vaccine / Q000009:adverse effects* / Q000276:immunology; D003300:Copper / Q000627:therapeutic use*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D007114:Immunization; D007153:Immunologic Deficiency Syndromes / Q000209:etiology* / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*
D000942:Antigens, Bacterial; D001500:BCG Vaccine; D004338:Drug Combinations; D011760:Pyrrolidinones; C042670:N-vinyl-2-pyrrolidinone; D003300:Copper
Polimermetallicheskie kompleksy belkovogo antigena mikobakteriĭ predotvrashchaiut disseminatsiiu postvaktsinal'noĭ infektsii pri T-defitsitnom sostoianii.