Stress analgesia: the opioid analgesia of long swims suppresses the non-opioid analgesia induced by short swims in mice.
In mice, room temperature swimming for as short a period as 15 sec has been found to induce a non-opioid analgesia with a time course of 10-12 min. As the duration of the swim is increased, an opioid analgesia develops with a longer persistence (25-30 min); the development of the opioid analgesia appears to suppress the expression of the non-opioid analgesia so that none of the latter is evident after 3 min swims. The characteristics of the tail-flick nociceptive test are also described.
Tierney
Garth
G
School of Physiology and Pharmacology, University of New South Wales, Kensington, SydneyAustralia.
Carmody
John
J
Jamieson
Dana
D
D000698:Analgesia; D000818:Animals; D004723:Endorphins / Q000494:pharmacology*; D005260:Female; D051379:Mice; D009619:Nociceptors / Q000187:drug effects; D010147:Pain Measurement; D013312:Stress, Physiological / Q000503:physiopathology*; D013550:Swimming; D013997:Time Factors
D004723:Endorphins