Newly recognized syndrome of cerebral, ocular, dental, auricular, skeletal anomalies: CODAS syndrome--a case report.
We report on a child with a unique constellation of congenital anomalies suggesting a new syndrome. These consist of developmental delay; craniofacial abnormalities, including bilateral cataracts, ptosis, median nasal groove, malformed ears with associated neurosensory hearing loss; dental anomalies consisting of anomalous cusp morphology with unusual pointed extensions and delayed tooth eruption; short stature with marked delay in epiphyseal ossification; coronal clefts involving vertebrae T11-S2; and dislocated hips. A literature search and use of a computer-assisted syndrome-identification program failed to uncover an identical case.
Shebib
S M
SM
Department of Pediatrics and Child Health, University of Manitoba, Canada.
Reed
M H
MH
Shuckett
E P
EP
Cross
H G
HG
Perry
J B
JB
Chudley
A E
AE
D000015:Abnormalities, Multiple / Q000145:classification* / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000002:abnormalities; D005124:Eye Abnormalities / Q000145:classification; D005147:Facial Bones / Q000002:abnormalities; D005260:Female; D006801:Humans; D007223:Infant; D011859:Radiography; D012886:Skull / Q000002:abnormalities; D013577:Syndrome; D014071:Tooth Abnormalities / Q000145:classification; D014463:Ultrasonography