Effect of pentacaine and ranitidine on gastric mucus changes induced by cold-restraint stress in rats.
The potential involvement of increased mucus secretion in the antiulcer activity of a cytoprotective agent, pentacaine, and of the H2-antagonist ranitidine was studied in stressed rats. Cold-restraint stress decreased the gastric mucus content and induced haemorrhagic erosions in the stomach. Pretreatment with pentacaine and ranitidine dose-dependently diminished the extent of stress-induced gastric damage. Pentacaine prevented the depletion of mucus after stress, while ranitidine failed to affect it. In non-stressed rats only pentacaine was able to enhance mucus secretion. The stimulating effect of pentacaine on gastric mucus secretion may account for some of its antiulcer properties.
Nosálová
V
V
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Juránek
I
I
Babulová
A
A
D000818:Animals; D002219:Carbamates / Q000494:pharmacology* / Q000627:therapeutic use; D002229:Carbenoxolone / Q000494:pharmacology; D003080:Cold Temperature; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D011899:Ranitidine / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control; D013312:Stress, Physiological / Q000209:etiology / Q000473:pathology*
D002219:Carbamates; C010618:pentacaine; D011899:Ranitidine; D002229:Carbenoxolone