Comparison of bacteriostatic and bactericidal activity of isoniazid and ethionamide against Mycobacterium avium and Mycobacterium tuberculosis.
Minimal inhibitory and bactericidal concentrations (MIC and MBC) of isoniazid and ethionamide were determined in 7H12 broth in experiments with 68 Mycobacterium avium strains and 14 wild drug-susceptible M. tuberculosis strains. MICs of isoniazid for M. tuberculosis were from 0.025 to 0.05 microgram/ml, and for M. avium from 0.6 to greater than 10.0 micrograms/ml. MICs of ethionamide for M. tuberculosis were from 0.3 to 1.25 micrograms/ml, and 42.7% of M. avium strains were within the same range. Isoniazid and ethionamide were highly bactericidal against M. tuberculosis, but they had very low bactericidal activity against M. avium.
Heifets
L B
LB
National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Lindholm-Levy
P J
PJ
Flory
M
M
D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D005000:Ethionamide / Q000494:pharmacology*; D007538:Isoniazid / Q000494:pharmacology*; D009162:Mycobacterium avium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009994:Osmolar Concentration; D011874:Radiometry
D005000:Ethionamide; D007538:Isoniazid