T-cell-mediated cytotoxicity.
There are two competing theories to explain the mechanism(s) by which cytolytic T lymphocytes kill target cells: granule exocytosis of a pore-forming protein, and contact-induced internal disintegration. Accumulated evidence supports alternative pathways in lymphocytoxicity, possibly reflecting distinct effector functions expressed by different killer cells and cells at different stages of activation.
Berke
G
G
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D006801:Humans; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000276:immunology; D008954:Models, Biological; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D012697:Serine Endopeptidases / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin; D012697:Serine Endopeptidases