title: Valproate in combat-related posttraumatic stress disorder.
abstract: BACKGROUND
  The symptoms of posttraumatic stress disorder (PTSD) suggest sympathetic nervous system hyperarousal and hyperreactivity. Pathophysiology of this condition may include stress-activated limbic kindling. Antikindling agents lithium and carbamazepine have been found effective for PTSD symptoms of intrusive reexperiencing and increased arousal. These facts suggest that valproate, another drug shown to interfere with limbic kindling, could also be effective for treatment of PTSD.
  
  
  METHODS
  An open clinical trial of valproate was conducted in 16 Vietnam veterans diagnosed with DSM-III-R combat-related PTSD.
  
  
  RESULTS
  Ten of 16 patients showed significant improvement, especially in hyperarousal/hyperreactivity symptoms.
  
  
  CONCLUSIONS
  The efficacy of valproate in the treatment of PTSD should be rigorously studied.
authors.affiliation: Psychiatry Service, Department of Veterans Affairs Medical Center, Seattle, WA 98108.
authors.forename: F A
authors.initials: FA
authors.lastname: Fesler
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology; D008032:Limbic System / Q000503:physiopathology; D008297:Male; D011569:Psychiatric Status Rating Scales; D011619:Psychotropic Drugs / Q000627:therapeutic use; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D014635:Valproic Acid / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D011619:Psychotropic Drugs; D014635:Valproic Acid