title: Formation and action of anticarcinogenic fatty acids.
abstract: Conjugated dienoic derivatives of linoleic acid (referred to by the acronym CLA) constitute a newly recognized class of anticarcinogenic fatty acids. Of the eight major CLA isomers, the cis-9, trans-11 isomer alone is incorporated into phospholipid and may be the most biologically relevant isomer. CLA exhibits potent antioxidant activity; evidence is presented indicating that CLA acts both as an in vitro and in vivo antioxidant. The formation of CLA in foods, and its possible biological significance in cell membranes, is discussed.
authors.affiliation: Department of Food Microbiology and Toxicology, University of Wisconsin, Madison 53706.
authors.forename: M W
authors.initials: MW
authors.lastname: Pariza
authors.forename: Y L
authors.initials: YL
authors.lastname: Ha
authors.forename: H
authors.initials: H
authors.lastname: Benjamin
authors.forename: J T
authors.initials: JT
authors.lastname: Sword
authors.forename: A
authors.initials: A
authors.lastname: Grüter
authors.forename: S F
authors.initials: SF
authors.lastname: Chin
authors.forename: J
authors.initials: J
authors.lastname: Storkson
authors.forename: N
authors.initials: N
authors.lastname: Faith
authors.forename: K
authors.initials: K
authors.lastname: Albright
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D005502:Food; D006801:Humans; D008041:Linoleic Acids / Q000378:metabolism* / Q000494:pharmacology; D012417:Rumen / Q000382:microbiology*
chemical_list: D008041:Linoleic Acids