title: Transdermal nitrate therapy: bioavailability during exercise increases transiently after the daily change of patch.
abstract: Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001). The two nitrate-concentration curves differed significantly (P less than 0.0001). Thus, change of patch augmented nitrate availability during exercise.
authors.affiliation: Oslo University Hospital Ullevål, Department of Cardiology, Norway.
authors.forename: K
authors.initials: K
authors.lastname: Gjesdal
authors.forename: T O
authors.initials: TO
authors.lastname: Klemsdal
authors.forename: E O
authors.initials: EO
authors.lastname: Rykke
authors.forename: J E
authors.initials: JE
authors.lastname: Bredesen
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D001682:Biological Availability; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D005996:Nitroglycerin