Stability of ceftazidime and amino acids in parenteral nutrient solutions.
The stability of ceftazidime was studied under conditions simulating administration via a Y-injection site into a primary infusion of parenteral nutrient (PN) solution; the stabilities of ceftazidime and amino acids when the drug was added directly to PN solutions were also studied. Three PN solutions containing 25% dextrose were used; the amino acid contents were 0, 2.5%, and 5%. Ceftazidime with sodium carbonate was used to prepare stock solutions of ceftazidime 40 mg/mL in both 0.9% sodium chloride injection and 5% dextrose injection; to simulate Y-site injection, samples were added to the three PN solutions to achieve ceftazidime concentrations of 10 and 20 mg/mL, or 1:1 and 1:3 ratios of drug solution to PN solution. Samples of these admixtures were assayed by high-performance liquid chromatography (HPLC) initially and after room-temperature (22 degrees C) storage for one and two hours. Additional solutions were prepared by adding sterile water for injection to ceftazidime with sodium carbonate; drug solutions were added to each PN solution in polyvinyl chloride bags to achieve ceftazidime concentrations of 1 and 6 mg/mL. The samples were assayed by HPLC for ceftazidime concentration after storage at 22 degrees C for 3, 6, 12, 24, and 36 hours and at 4 degrees C for 1, 3, 7, and 14 days. Amino acid stability was analyzed in admixtures containing 5% amino acids and ceftazidime 6 mg/mL after 24 and 48 hours at 22 degrees C and after 7 and 10 days at 4 degrees C.(ABSTRACT TRUNCATED AT 250 WORDS)
Wade
C S
CS
Northeast Georgia Medical Center, Gainesville.
Lampasona
V
V
Mullins
R E
RE
Parks
R B
RB
D000596:Amino Acids / Q000032:analysis / Q000737:chemistry*; D002442:Ceftazidime / Q000032:analysis / Q000737:chemistry*; D004338:Drug Combinations; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007552:Isotonic Solutions; D010289:Parenteral Nutrition, Total
D000596:Amino Acids; D004338:Drug Combinations; D007552:Isotonic Solutions; D002442:Ceftazidime