[Changes in virulence of Enterobacteriaceae in the presence of sub-inhibitory levels of antibiotics].
The effect of subinhibitory concentrations of antimicrobial agents such as chloramphenicol, tetracycline, rifampicin and nalidixic acid on various factors of virulence in Shigella spp. and enteroinvasive colon bacilli was studied. It was shown that under such conditions changes took place in various events of the interaction with the epithelial cells, i.e. in adhesion, penetration, intracellular multiplication and transfers between contacting cells. The total effect of chloramphenicol resulted in increasing of the virulence while that of nalidixic acid, tetracycline and rifampicin resulted in its decreasing.
Tets
V V
VV
Norman
L L
LL
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D002701:Chloramphenicol / Q000008:administration & dosage / Q000494:pharmacology; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects / Q000472:pathogenicity*; D066298:In Vitro Techniques; D009268:Nalidixic Acid / Q000008:administration & dosage / Q000494:pharmacology; D012293:Rifampin / Q000008:administration & dosage / Q000494:pharmacology; D012763:Shigella flexneri / Q000187:drug effects / Q000472:pathogenicity*; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology; D014774:Virulence / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003470:Culture Media; D009268:Nalidixic Acid; D002701:Chloramphenicol; D013752:Tetracycline; D012293:Rifampin
Izmenenie virulentnosti énterobakteriĭ v prisutstvii sub- ingibiruiushchikh kontsentratsiĭ antibiotikov.