title: Correlation between the occurrence of lupus nephritis, anti-erythrocyte autoantibodies and V kappa haplotype in NZB x 129/J and NZB x SM/J recombinant inbred murine strains.
abstract: The NZB mouse is genetically predisposed to the development of autoimmune disease that resembles the human autoimmune systemic lupus erythematosus and autoimmune hemolytic anemia, with increased titers of anti-DNA, and Coombs' autoantibodies. The various autoimmune traits are controlled separately by a limited number of genes. Genetic studies have shown that several immune loci are involved in autoimmunity: T cell abnormalities, H-2 complex and immunoglobulin genes have been implicated. In this report, we present evidence for a significant correlation of NZB V kappa 1 haplotype defined by restriction fragment length polymorphism analysis with anti-erythrocyte autoantibodies in NZB x 129/J and NZB x SM/J recombinant inbred lines.
authors.affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029.
authors.forename: N C
authors.initials: NC
authors.lastname: Bailey
authors.forename: A
authors.initials: A
authors.lastname: Bona
authors.forename: S
authors.initials: S
authors.lastname: Dikman
authors.forename: F
authors.initials: F
authors.lastname: Bonilla
authors.forename: F W
authors.initials: FW
authors.lastname: Alt
authors.forename: C
authors.initials: C
authors.lastname: Bona
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D004912:Erythrocytes / Q000276:immunology*; D005803:Genes, Immunoglobulin; D005802:Genes, MHC Class II; D006239:Haplotypes; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D008181:Lupus Nephritis / Q000209:etiology*; D051379:Mice; D008814:Mice, Inbred NZB; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D011995:Recombination, Genetic
chemical_list: D001323:Autoantibodies; D000949:Histocompatibility Antigens Class II; D011948:Receptors, Antigen, T-Cell