Effects of MPTP, MPP+, and paraquat on NADPH-dependent lipid peroxidation in mouse brain and lung microsomes.
Both MPTP and MPP+ inhibited the NADPH-dependent microsomal LPO in mouse brain and lung. On the other hand, PQ significantly stimulated the LPO in brain microsomes in a dose-dependent manner. The herbicide, however, stimulated lung microsomal LPO only in a narrow concentration range, despite much higher P450 reductase activity in lung microsomes than that in brain microsomes. These findings suggest that the effect of PQ on microsomal LPO is different from those of the analogous neurotoxins, MPTP and MPP+, and is not uniform in brain and lung.
Hara
S
S
Department of Forensic Medicine, Tokyo Medical College, Japan.
Endo
T
T
Kuriiwa
F
F
Kano
S
S
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D015655:1-Methyl-4-phenylpyridinium / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung / Q000201:enzymology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008861:Microsomes / Q000201:enzymology; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D010269:Paraquat / Q000494:pharmacology*
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D009251:NADPH-Ferrihemoprotein Reductase; D010269:Paraquat; D015655:1-Methyl-4-phenylpyridinium