title: Effects of recombinant porcine somatotropin on metabolic rate in growing pigs.
abstract: Effects of recombinant porcine somatotropin (rpST) on metabolic rate were studied in two trials with 24 crossbred barrows (Yorkshire x Landrace) in each. The barrows weighed about 80 kg (SE within trials 2.2 kg) at the start of the measurements and in each trial 12 pigs received 4 mg of rpST and 12 received a placebo. The diet contained 2.57 Mcal NE/kg and 20% CP (about 1% lysine). Animals were fed approximately 2.8 times maintenance (280 kcal ME.kg-.75.d-1). Heat production (gaseous exchange of CO2 and O2) and activity were measured continuously. Heat production associated with activity was calculated from the regression of heat production on activity. Animals treated with rpST exceeded controls in rate of gain by 252 g/d (P less than .001) and in metabolic rate by 14.5 kcal.kg-.75.d-1 (P less than .01). The rpST treatment increased rectal (+ .2 degrees C) and surface (+ .8 degrees C) temperatures. Activity-related heat production in treated pigs was increased, but this was only partly related to the increase in metabolic rate with rpST. The daily patterns of total and activity-related heat production were similar between pigs in both experimental treatments.
authors.affiliation: Dept. of Anim. Prod., Agricultural University, Wageningen, The Netherlands.
authors.forename: M W
authors.initials: MW
authors.lastname: Verstegen
authors.forename: W
authors.initials: W
authors.lastname: van der Hel
authors.forename: H A
authors.initials: HA
authors.lastname: Brandsma
authors.forename: A M
authors.initials: AM
authors.lastname: Henken
authors.forename: E
authors.initials: E
authors.lastname: Kanis
authors.forename: P
authors.initials: P
authors.lastname: van der Wal
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D002149:Energy Intake; D004734:Energy Metabolism / Q000187:drug effects*; D013006:Growth Hormone / Q000494:pharmacology*; D016018:Least-Squares Analysis; D008297:Male; D011994:Recombinant Proteins / Q000494:pharmacology; D013552:Swine / Q000378:metabolism*
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone