[The effect of morphine and naloxone on the interaction of afferent signals of differing modalities in the spinal cord].
The effect of the electrical nerve stimulation with low (2-4 V, 100 Hz, 5 min) and high (45 V, 1 Hz, 1 min) intensity on the nociceptive responses in the ventrolateral tracts was studied in unanesthetized rats with the transsected spinal cord. Both kinds of stimulation reduced nociceptive responses but the effect of low-intensity stimulations was diminished when they were repeated and was absent over 24 hours after spinalization. The effect of low-intensity stimulation was abolished by naloxone (0.1 and 1 mg/kg) and was reduced during the antinociceptive effect of morphine (1 and 4 mg/kg). The effect of high-intensity stimulation was preserved over 24 hours after spinalization and after repeated stimulations. It was not changed by naloxone and morphine.
Bogdanov
M B
MB
D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D003655:Decerebrate State / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation / Q000379:methods; D006358:Hot Temperature / Q000009:adverse effects; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
D009270:Naloxone; D009020:Morphine
Vliianie morfina i naloksona na vzaimodeĭstvie afferentnykh signalov raznoĭ modal'nosti v spinnom mozge.