[Stability at different pH of polyene antibiotics derived from partricin].
The degradation of a new semisynthetic polyene antibiotic partricin A dimethylamino ethylamide diaspartate (SPA-S-717) at 37 degrees C in water at different pH is studied. It is found to be sensitive to acidic pH and much less sensitive near neutrality. Then a linear relation between pH and logarithm of reaction rate constant is detected. This fact therefore can give some directions as regards the drug somministration in view of pharmacological and clinical trials.
Mozzi
G
G
Laboratori di Ricerca della SPA, Società Prodotti Antibiotici S.p.A., Milano.
Mirabelli
L
L
Nipoti
V R
VR
D000900:Anti-Bacterial Agents / Q000032:analysis*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D011090:Polyenes / Q000032:analysis* / Q000737:chemistry
D000900:Anti-Bacterial Agents; D011090:Polyenes; C100293:partricin
Stabilità a vari pH di un nuovo antibiotico polienico derivato dalla partricina.