title: Home treatment of febrile neutropenia: an empirical oral antibiotic regimen.
abstract: Between May 1988 and November 1989, 68 consecutive febrile courses supervening after polychemotherapy for lymphoma outpatients (median age 50 years) were treated by the combination of oral Pefloxacin/Amoxicillin Clavulanic acid. In terms of median data, neutropenia appeared on d9 [d1-d17], and lasted 5 days [2-9] with a PMN nadir observed at 0.104 x 10(9) [0-0.5 x 10(9)/l], while fever rose on d10 [1-24]. In 59 cases (87%), fever and/or focal symptoms disappeared within 3 days, after which treatment was maintained for 7 days. Nine failures were observed, of which 2 were due to abandonment of treatment, 2 to vomiting and 5 to persistence of the original symptoms. Meti Susceptible-Staphylococci were found in blood samples from 2 patients, one of whom, with grade IV lymphoma that had proved resistant to chemotherapy, died. The treatment was found to be effective and well tolerated, offering a good alternative to hospitalization during a transient chemotherapy-induced neutropenia.
authors.affiliation: Service des Maladies du Sang des Centres Hospitaliers et Universitaires, Angers, France.
authors.forename: M
authors.initials: M
authors.lastname: Gardembas-Pain
authors.forename: B
authors.initials: B
authors.lastname: Desablens
authors.forename: L
authors.initials: L
authors.lastname: Sensebe
authors.forename: T
authors.initials: T
authors.lastname: Lamy
authors.forename: C
authors.initials: C
authors.lastname: Ghandour
authors.forename: M
authors.initials: M
authors.lastname: Boasson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008223:Lymphoma / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy*; D015366:Pefloxacin / Q000008:administration & dosage; D011446:Prospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D019818:Clavulanic Acid; D015366:Pefloxacin; D000658:Amoxicillin