Interaction between pressor and depressor areas in cat ventrolateral medulla.
The purpose of the present study was to investigate whether stimulation of the caudal depressor area (CA) in the medulla lowered blood pressure (BP) by enhancing GABA release at the intermediate pressor area (IA) of the medulla. Application of the excitotoxin kainic acid (KA; 40 mM solution) to the caudal area lowered BP as has been previously described (Gatti, et al., Brain Research, 330 (1985) 21-29). Subsequent IA application of the GABA receptor antagonists picrotoxin (100 micrograms/side) or bicuculline (10 micrograms/side) consistently reversed this hypotensive effect. Picrotoxin raised BP by 92 +/- 10 mmHg (n = 5) after KA while by itself, picrotoxin only increased BP by 23 +/- 7.0 mmHg (n = 3) when applied to the IA. This effect was significantly greater following KA application to the caudal area (P less than 0.05). Likewise, bicuculline raised BP by 74 +/- 8.7 mmHg (n = 7) following KA while by itself, bicuculline only increased BP by 24 +/- 8.2 mmHg when applied to the IA (n = 4). This also was significantly different. This potentiation was not seen with the glycine receptor antagonist, strychnine. These data indicate that there is a GABAergic input from the caudal to the intermediate ventral surface areas of the cat which is involved in the central control of BP.
Gatti
P J
PJ
Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059.
Gillis
R A
RA
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D005260:Female; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D008959:Models, Neurological; D009928:Organ Specificity; D010852:Picrotoxin / Q000494:pharmacology*; D013331:Strychnine / Q000494:pharmacology*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D001640:Bicuculline; D007608:Kainic Acid; D010852:Picrotoxin; D013331:Strychnine; D005680:gamma-Aminobutyric Acid