5,7-Dihydroxytryptamine injections increase glial fibrillary acidic protein in the hypothalamus of adult rats.
The distribution and levels of glial fibrillary acidic protein (GFAP) were determined in the adult rat hypothalamus following axotomy of serotonin (5-HT) neurons. Seven days after unilateral intrahypothalamic injection of the 5-HT neurotoxin, 5,7-dihydroxytryptamine, there was a marked increase in the number of GFAP-labelled astrocytes in the ipsilateral hypothalamus of 5,7-DHT-treated as compared to sham-treated rats. In addition, levels of GFAP were significantly increased 7 days after 5,7-DHT injection.
Frankfurt
M
M
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021.
O'Callaghan
J
J
Beaudet
A
A
D015116:5,7-Dihydroxytryptamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D007839:Functional Laterality; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D005904:Glial Fibrillary Acidic Protein; D015116:5,7-Dihydroxytryptamine