title: Megakaryoblastic leukemia with an N-ras mutation and late acquisition of a Philadelphia chromosome.
abstract: A patient is described with de novo acute non-lymphocytic leukemia of megakaryoblastic lineage with tri-lineage myelodysplasia. This patient was studied cytogenetically and using molecular genetic techniques throughout her clinical course. She had an N-ras mutation at diagnosis which persisted despite a bone marrow transplant, and acquired a Philadelphia chromosome associated with a P190 BCR-ABL transcript at clinical relapse 3 months post-transplantation.
authors.affiliation: Centre for Human Genetics, University of Leuven, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Vandenberghe
authors.forename: P
authors.initials: P
authors.lastname: Martiat
authors.forename: M
authors.initials: M
authors.lastname: Baens
authors.forename: M
authors.initials: M
authors.lastname: Stul
authors.forename: A
authors.initials: A
authors.lastname: Ferrant
authors.forename: A
authors.initials: A
authors.lastname: Cuneo
authors.forename: J J
authors.initials: JJ
authors.lastname: Cassiman
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000328:Adult; D001483:Base Sequence; D002871:Chromosome Banding; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D011905:Genes, ras; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics* / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000737:chemistry; D016133:Polymerase Chain Reaction; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D013997:Time Factors
chemical_list: D009841:Oligonucleotides; D016044:Fusion Proteins, bcr-abl; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)