Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas' disease.
Infection of several mouse strains with Trypanosoma cruzi stimulates high levels of T and B lymphocyte activities which persist during the chronic phase and is followed by specific immunosuppression and severe autoimmune pathology. Infected BALB.Xid mice carrying an X-linked mutation and lacking CD5 B cells, display poor B cell responses to T. cruzi infection, accompanied by low levels of specific and non-specific immunoglobulins in the serum. However, these animals control parasitemia, do not show the wasting observed in BALB/c mice, and develop almost no pathology early in the chronic phase. The infection of (BALB.Xid female x BALB/c male) F1 animals shows that immunodefective males behave like Xid animals in contrast to females which respond as normal BALB/c mice. These results indicate that the Xid locus controls lymphocyte responses, parasite clearance and pathology in experimental Chagas' disease.
Minoprio
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Unité d'Immunoparasitologie, Institut Pasteur, Paris, France.
Coutinho
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Spinella
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Hontebeyrie-Joskowicz
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D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D002598:Chagas Cardiomyopathy / Q000276:immunology; D014355:Chagas Disease / Q000150:complications / Q000235:genetics / Q000276:immunology*; D002908:Chronic Disease; D005260:Female; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000235:genetics / Q000469:parasitology*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008817:Mice, Mutant Strains / Q000235:genetics / Q000276:immunology / Q000469:parasitology*; D014349:Trypanosoma cruzi / Q000276:immunology / Q000302:isolation & purification*
D000913:Antibodies, Protozoan