[Experimental hepatitis E infection in piglets].
A sample of patient's faeces containing virus-like particles (VLP) of 27-34 nm was obtained during an outbreak of hepatitis E in the Kirghiz SSR. The identity of the VLP to hepatitis E virus and etiological association with the disease were demonstrated by immune electron microscopy and infection of Macaca fascicularis monkeys. This isolate of hepatitis E virus is able to induce experimental infection in domestic piglets which was very similar to experimental hepatitis E in primates when infected orally, intravenously and by the combined routes. The clinical manifestations included acute biochemical and histological hepatitis, excretion of hepatitis E virus in faeces, icteric sclerae and skin, hepatitis virus presence in the material from mesenteric lymph nodes. Immunosuppression aggravated hepatitis E infection in piglets. Piglet-to-piglet transmission of hepatitis E virus was demonstrated. During passages of the virus in piglets a shortening of the incubation period and the absence of jaundice was observed.
Usmanov
R K
RK
Balaian
M S
MS
Dzhumalieva
D I
DI
Alymbaeva
D B
DB
Korolev
M B
MB
Karas'
F R
FR
Zamiatina
N A
NA
Berdikozhoeva
S K
SK
Karymshakova
Ch T
ChT
Kozhomkulov
E T
ET
D000818:Animals; D005243:Feces / Q000382:microbiology; D006508:Hepatitis Antibodies / Q000097:blood; D006518:Hepatitis Viruses / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D006524:Hepatitis, Viral, Animal / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000382:microbiology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008252:Macaca fascicularis; D013552:Swine; D013553:Swine Diseases / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology
D006508:Hepatitis Antibodies
Eksperimental'naia infektsiia gepatita E u porosiat.