[The influence of calcium ion antagonists on the effects of bradykinin].
On the isolated segments of the ileum of the guinea-pig, anesthetized and nonanesthetized rats and mice it was established that calcium ion antagonists from different chemical series exert the nonspecific antibradykinin action, reducing the main biological effects of bradykinin--myotropic, depressor, nociceptive and microcirculatory. To a greater extent the mentioned properties show up in the derivatives of 1,4-dihydropyridine (phoridon, etc.) that may play the certain role in the therapeutic action of the drugs in the diseases associated with the activation of the kinin system of the organism.
Shvarts
G Ia
GIa
Rumiantsev
E A
EA
Siubaev
R D
RD
Faermark
I F
IF
D000818:Animals; D001920:Bradykinin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced; D005260:Female; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007705:Kinins / Q000096:biosynthesis / Q000187:drug effects; D008297:Male; D051379:Mice; D051381:Rats; D013035:Spasm / Q000139:chemically induced
D002121:Calcium Channel Blockers; D007705:Kinins; D001920:Bradykinin
Vliianie antagonistov ionov kal'tsiia na éffekty bradikinina.