Production of 13 plasma proteins by human testicular yolk sac tumor transplanted into nude mice.
Thirteen human proteins were found in plasma and cystic fluid of mice bearing human testicular yolk sac tumor. Six of them, alpha-fetoprotein, prealbumin, albumin, alpha 1-antitrypsin, hemopexin and transferrin, had been previously demonstrated to be produced by yolk sac tumors. The syntheses of the remaining seven, namely apolipoprotein A1, retinol-binding protein, alpha 2HS-glycoprotein, haptoglobin, apolipoprotein B, C5 component and anti-hemophilic factor, have been demonstrated for the first time.
Nishi
S
S
Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan.
Nishita
T
T
Ohkawa
K
K
D000328:Adult; D000818:Animals; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000096:biosynthesis; D001055:Apolipoproteins B / Q000096:biosynthesis; D001798:Blood Proteins / Q000096:biosynthesis*; D003182:Complement C5 / Q000096:biosynthesis; D005169:Factor VIII / Q000096:biosynthesis; D005260:Female; D006242:Haptoglobins / Q000096:biosynthesis; D006801:Humans; D007106:Immune Sera / Q000378:metabolism; D008297:Male; D008649:Mesonephroma / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009368:Neoplasm Transplantation; D012177:Retinol-Binding Proteins / Q000096:biosynthesis; D054839:Retinol-Binding Proteins, Plasma; D013736:Testicular Neoplasms / Q000378:metabolism*
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D001798:Blood Proteins; D003182:Complement C5; D006242:Haptoglobins; D007106:Immune Sera; D009363:Neoplasm Proteins; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma; D005169:Factor VIII