Practical methods for chemical inactivation of Creutzfeldt-Jakob disease pathogen.
Chemical inactivation of pathogen of Creutzfeldt-Jakob disease (CJD) was examined using the mouse-adapted CJD strain. A high concentration of formic acid, guanidine compounds, trichloroacetate and phenol prevented CJD transmission. NaOH between 0.25 and 2 N lengthened the incubation periods. Sodium dodecyl sulfate (SDS) in a concentration between 1 and 3% did not alter incubation at room temperature but did completely block the transmission after boiling for 3 min in 3% SDS. This method is recommended for practical disinfection.
Tateishi
J
J
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka.
Tashima
T
T
Kitamoto
T
T
D000143:Acids; D000438:Alcohols; D000468:Alkalies; D000818:Animals; D001921:Brain / Q000382:microbiology; D007562:Creutzfeldt-Jakob Syndrome / Q000382:microbiology*; D004195:Disease Models, Animal; D004203:Disinfection; D005260:Female; D051379:Mice; D011328:Prions; D014774:Virulence; D014775:Virus Activation
D000143:Acids; D000438:Alcohols; D000468:Alkalies; D011328:Prions