title: Thyroid stimulating hormone response to thyrotropin in prepubertal depression.
abstract: In an effort to evaluate whether differences exist in the hypothalamic-pituitary-thyroid axis of depressed children, a thyrotropin releasing hormone (TRH) stimulation test was administered to 55 prepubertal subjects who were divided into three groups matched for age and sex: a depressed group (endogenous N = 15, nonendogenous N = 15), a psychiatric nondepressed control group (N = 16), and a normal control group (N = 9). Each subject was tested at two dosages of TRH, 2 micrograms/kg and 7 micrograms/kg. Increasing age and female sex were positively correlated with a greater thyroid stimulating hormone (TSH) response. TSH response to TRH was examined with subjects reclassified by severe suicidal ideation, severe aggression, and parental history of alcoholism. Results of this study are contrasted with the adult psychiatric literature.
authors.affiliation: University of California, San Diego.
authors.forename: M R
authors.initials: MR
authors.lastname: Garcia
authors.forename: N D
authors.initials: ND
authors.lastname: Ryan
authors.forename: H
authors.initials: H
authors.lastname: Rabinovitch
authors.forename: P
authors.initials: P
authors.lastname: Ambrosini
authors.forename: J
authors.initials: J
authors.lastname: Twomey
authors.forename: S
authors.initials: S
authors.lastname: Iyengar
authors.forename: H
authors.initials: H
authors.lastname: Novacenko
authors.forename: B
authors.initials: B
authors.lastname: Nelson
authors.forename: J
authors.initials: J
authors.lastname: Puig-Antich
mesh_terms: D000367:Age Factors; D000374:Aggression / Q000523:psychology; D002648:Child; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D012737:Sex Factors; D013405:Suicide / Q000523:psychology; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin