Successful use of cisplatin to treat metastatic seminoma during cisplatin-induced acute renal failure.
A chemotherapeutic regimen including cisplatin was administered to a man with extragonadal seminoma and cisplatin-induced acute renal failure. Three doses of cisplatin (30, 50, and 100 mg/m2) were given in conjunction with hemodialysis. Pharmacokinetic data for free and total plasma platinum were obtained. The patient also received one dose of carboplatin and a course of radiation therapy. Complete remission was achieved, and useful renal function returned. Cisplatin can be used successfully during acute renal failure.
Fox
J G
JG
Renal Unit, Royal Infirmary, Glasgow, United Kingdom.
Kerr
D J
DJ
Soukop
M
M
Farmer
J G
JG
Allison
M E
ME
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects* / Q000097:blood; D004407:Dysgerminoma / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012074:Remission Induction; D006435:Renal Dialysis; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy*
D016190:Carboplatin; D002945:Cisplatin