title: Hematological toxicity of adjuvant portal liver infusion with fluorouracil, mitomycin and heparin.
abstract: Adjuvant perioperative liver infusion chemotherapy with fluorouracil, mitomycin and heparin caused mild but significant myelosuppression in the first two postoperative weeks. This was associated with a slightly increased bleeding tendency. Mortality was not increased. Future trials might combine chemotherapy with hematopoietic growth factors in order to minimize myelosuppression.
authors.affiliation: Group for Epidemiologic and Clinical Cancer Research (SAKK), Berne, Switzerland.
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: U
authors.initials: U
authors.lastname: Metzger
authors.forename: U
authors.initials: U
authors.lastname: Laffer
authors.forename: R
authors.initials: R
authors.lastname: Egeli
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use / Q000633:toxicity*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000633:toxicity; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000187:drug effects; D006493:Heparin / Q000008:administration & dosage* / Q000633:toxicity; D006801:Humans; D007262:Infusions, Intravenous; D007958:Leukocyte Count / Q000187:drug effects*; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage* / Q000633:toxicity; D010976:Platelet Count / Q000187:drug effects*; D011169:Portal Vein; D011897:Random Allocation; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D006454:Hemoglobins; D008937:Mitomycins; D016685:Mitomycin; D006493:Heparin; D005472:Fluorouracil