title: Response of depression to very high plasma levels of imipramine plus desipramine.
abstract: Forty-five depressed patients were treated with imipramine for 6 weeks. Seven of 7 patients (100%) who had plasma levels of imipramine plus desipramine greater than 500 ng/ml showed a 50% or greater improvement in Hamilton depression scores compared with 23 of 38 patients (60%) with plasma levels less than 500 ng/ml (p less than 0.057).
authors.affiliation: Department of Psychiatry, University of Iowa College of Medicine, Iowa City.
authors.forename: M
authors.initials: M
authors.lastname: Garvey
authors.forename: R J
authors.initials: RJ
authors.lastname: DeRubeis
authors.forename: S D
authors.initials: SD
authors.lastname: Hollon
authors.forename: M D
authors.initials: MD
authors.lastname: Evans
authors.forename: V B
authors.initials: VB
authors.lastname: Tuason
mesh_terms: D000328:Adult; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D003891:Desipramine / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D008297:Male; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics
chemical_list: D007099:Imipramine; D003891:Desipramine