[The effect of hydrocortisone on the activity of the alkaline proteinase systems in the rat thymus].
The effect of single and chronic administration of hydrocortisone on the thymus proteinase activity in the alkaline pH range was studied on rats. The presence in the thymus of the glucocorticoid-sensitive alkaline proteinase system induced by hydrocortisone was shown. A decrease of the activity of the system in the adrenalectomized animals was found. The possible relationship between the thymolytic effects of hydrocortisone and the increased activity of the alkaline proteinase systems of the thymus is concluded.
Ogurtsov
S I
SI
Dukhanin
A S
AS
Sergeev
P V
PV
Eĭiubova
A A
AA
D000315:Adrenalectomy; D000818:Animals; D004305:Dose-Response Relationship, Drug; D010450:Endopeptidases / Q000096:biosynthesis / Q000187:drug effects*; D004790:Enzyme Induction / Q000187:drug effects; D006854:Hydrocortisone / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008297:Male; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects* / Q000201:enzymology; D013997:Time Factors
D010450:Endopeptidases; D006854:Hydrocortisone
Vliianie gidrokortizona na aktivnost' shchelochnykh proteinaznykh sistem v timuse krys.