title: [IgM myeloma: a report of 2 cases].
abstract: The IgM myeloma is a rare type of multiple myeloma (MM) with some features which differentiate it from other immunologic types of myeloma and from Waldenström macroglobulinemia (WM). Two patients with IgM myeloma in whom the only clinical feature of the disease was the development of bone lesions and general deterioration are reported. In none of the cases an M component was detected in proteinogram. A bone marrow proliferation of plasma cells was discovered in both, which it was accompanied with dura mater infiltration in one of them. The type of secreted immunoglobulin was IgM lambda in the first case and kappa in the second. Both patients had a poor clinical course after the diagnosis and died due to infective complications. Emphasis is made on the need to differentiate this condition from WM due to their different prognosis and therapy.
authors.affiliation: Servicio de Medicina Interna, General Hospital Clínic i Provincial, Barcelona.
authors.forename: F
authors.initials: F
authors.lastname: Masanés
authors.forename: E
authors.initials: E
authors.lastname: Pedrol
authors.forename: J
authors.initials: J
authors.lastname: Bladé
authors.forename: J
authors.initials: J
authors.lastname: Casademont
authors.forename: A
authors.initials: A
authors.lastname: de la Sierra
authors.forename: F
authors.initials: F
authors.lastname: Martínez-Orozco
authors.forename: J M
authors.initials: JM
authors.lastname: Grau
authors.forename: M
authors.initials: M
authors.lastname: Ingelmo
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000175:diagnosis
chemical_list: D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains
vernacular_title: Mieloma IgM: presentación de dos casos.