[The effect of the carnitine biosynthesis inhibitor mildronate on the lipid metabolic indices of rats].
The course administration of a carnitine biosynthesis inhibitor mildronate (100 mg/kg, orally, for 10 and 30 days) was shown to increase the rat blood serum concentration of free fatty acids. By the 30th day of the treatment no changes in the rat myocardium contents of free fatty acids, triglycerides and cholesterol were found that along with the prevention of the accumulation of long chain metabolites of fatty acids in the heart under conditions of adrenergic actions indicated the pathogenetically right approach to the treatment of ischemic heart disease with mildronate.
Shutenko
Zh V
ZhV
Priedena
I A
IA
Mezhapuke
R Ia
RIa
Simkhovich
B Z
BZ
Kalvin'sh
I Ia
IIa
Lukevits
E Ia
EIa
D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology*; D002331:Carnitine / Q000037:antagonists & inhibitors*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D050356:Lipid Metabolism; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002317:Cardiovascular Agents; D005230:Fatty Acids, Nonesterified; D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate; D002331:Carnitine
Vliianie ingibitora biosinteza karnitina mildronata na nekotorye pokazateli lipidnogo obmena u krys.