[The relationship of hypoperfusion and dementia caused by cerebral amyloid angiopathy].
The pathohistologic study was conducted on the brain of a dementia patient caused by simple cerebral amyloid angiopathy and the neural cell counts of cerebral cortices was compared with that of two normal subjects of same age. Medium to small arteries and capillaries of leptomeninges and cortices exhibited amyloid deposits. The occipital lobe was predominantly affected. 53.3% of medium to small arteries and 25.3% capillaries showed the abnormality. Decrease of neural cells also varied considerably. The occipital lobe was involved most severely and 54.8% neural cells lost in this lobe. The increase of amyloid deposits was closely related to the severity of ischemic lesion and loss of neurons. The findings in this patient indicated that the pathogenesis of dementia caused by cerebral amyloid angiopathy might be more complicated. The possible mechanism might be that the deposition of amyloid destroyed the structure of cerebral vasculature and lead to the impairment of autoregulation. These pathologic changes resulted in hypoperfusion which caused ischemic changes and loss of neurons and dementia.
Zhai
L
L
PLA General Hospital, Beijing.
Wang
L N
LN
D000368:Aged; D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000150:complications* / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000378:metabolism; D015140:Dementia, Vascular / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D009778:Occipital Lobe / Q000378:metabolism / Q000473:pathology
D000682:Amyloid