title: The Interleukin-6-dependent DNA-binding protein gene (transcription factor 5: TCF5) maps to human chromosome 20 and rat chromosome 3, the IL6 receptor locus (IL6R) to human chromosome 1 and rat chromosome 2, and the rat IL6 gene to rat chromosome 4.
abstract: Using two panels of somatic cell hybrids segregating either human or rat chromosomes, the gene encoding the interleukin-6-dependent DNA-binding protein, also called liver activator protein (designated transcription factor 5: TCF5), was assigned to human chromosome 20 and to rat chromosome 3. The TCF5 gene might be identical with the NF-IL6 gene. The locus encoding the IL6 receptor gene (IL6R) was localized to human chromosome 1 and rat chromosome 2. An IL6R-like (IL6RL) locus was also assigned to human chromosome 9. In addition, the rat interleukin-6 (IL6) gene was assigned to rat chromosome 4. These mapping data allow one to extend comparison between the rat, mouse, and human gene maps.
authors.affiliation: Université Libre de Bruxelles, Département de Biologie Moléculaire, Rhode-St-Genèse, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Szpirer
authors.forename: C
authors.initials: C
authors.lastname: Szpirer
authors.forename: M
authors.initials: M
authors.lastname: Rivière
authors.forename: C
authors.initials: C
authors.lastname: Houart
authors.forename: M
authors.initials: M
authors.lastname: Baumann
authors.forename: G H
authors.initials: GH
authors.lastname: Fey
authors.forename: V
authors.initials: V
authors.lastname: Poli
authors.forename: R
authors.initials: R
authors.lastname: Cortese
authors.forename: M Q
authors.initials: MQ
authors.lastname: Islam
authors.forename: G
authors.initials: G
authors.lastname: Levan
mesh_terms: D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20; D002899:Chromosomes, Human, Pair 9; D004268:DNA-Binding Proteins / Q000235:genetics*; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D015850:Interleukin-6 / Q000235:genetics*; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics*; D051381:Rats / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D019947:Receptors, Interleukin-6; D013045:Species Specificity
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; D005819:Genetic Markers; D015850:Interleukin-6; D009687:Nuclear Proteins; D011971:Receptors, Immunologic; D019947:Receptors, Interleukin-6