Origin of malignant centrofacial granulomas: surface markers and gene rearrangement of malignant cells.
Malignant centrofacial granuloma (MCFG) is a clinical entity characterized by a relentless ulceration of the upper airway involving the nose, palate, and face, without any demonstrable etiology. The origin of 11 cases were analyzed with the help of cell-surface immunostaining in all and with T-cell receptor gene (TCR) rearrangement in 3. The results show that most of the cases of MCFG are in fact T-cell lymphomas with cell-surface antigens (CD2, CD7, CD3) consistent with either early or mature T lymphocytes. However, some cases exhibit B-lymphoid (CD19, CD20) or histiomonocytic (CD13, CD14) lineage-specific markers. In conclusion, despite its remarkable clinical unity, MCFG is a heterogeneous group of neoplastic diseases, most but not all of which may be classified as T-cell lymphoma.
Cabane
J
J
Department of Internal Medicine, Saint-Antoine Hospital, Paris, France.
Raphaël
M
M
Lamas
G
G
Mossalayi
D
D
Dubois
A
A
Chomette
G
G
Godeau
P
P
Marty-Double
C
C
Rossi
J F
JF
D015703:Antigens, CD / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D002454:Cell Differentiation; D015321:Gene Rearrangement; D006103:Granuloma, Lethal Midline / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016399:Lymphoma, T-Cell / Q000145:classification; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D000954:Antigens, Surface