Increase in the cytosolic concentration of calcium in platelets of diabetics type II.
The intracellular concentration of calcium (Cai) was measured in platelets of healthy control subjects and diabetics type II. Cai was elevated in platelets of diabetics type II under basal conditions, after stimulation by collagen, in the presence and absence of calcium in the incubation medium. The increase in Cai after stimulation by collagen was inhibited by nitrendipine in both kinds of platelets, however Cai remained elevated in platelets of diabetics. Our data and findings of others may be understood as indications of disturbances in the handling of Cai in diabetes.
Tschöpe
D
D
Diabetes Research Institute, Düsseldorf, FRG.
Rösen
P
P
Gries
F A
FA
D000368:Aged; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D003094:Collagen / Q000494:pharmacology; D003600:Cytosol / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000209:etiology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000494:pharmacology
D003094:Collagen; D009568:Nitrendipine; D002118:Calcium