title: Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone OKT3.
abstract: An 18-yr-old woman with cystic fibrosis who received a double-lung transplant developed a severe episode of acute lung rejection. Bronchoalveolar lavage and transbronchial biopsy were used to establish the diagnosis. The rejection was refractory to administration of high-dose pulse steroids. OKT3 therapy was successfully used to reverse this episode. This is the first case report of a steroid-resistant double-lung allograft rejection successfully treated with OKT3.
authors.affiliation: McGill Lung Transplant Program, Montreal General Hospital, Quebec, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Shennib
authors.forename: M
authors.initials: M
authors.lastname: Mercado
authors.forename: D
authors.initials: D
authors.lastname: Nguyen
authors.forename: P
authors.initials: P
authors.lastname: Ernst
authors.forename: F
authors.initials: F
authors.lastname: Lebel
authors.forename: M
authors.initials: M
authors.lastname: O'Donovan
authors.forename: R
authors.initials: R
authors.lastname: Fraser
authors.forename: C
authors.initials: C
authors.lastname: Tchervenkov
authors.forename: J F
authors.initials: JF
authors.lastname: Morin
authors.forename: D
authors.initials: D
authors.lastname: Mulder
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D016040:Lung Transplantation; D008775:Methylprednisolone / Q000627:therapeutic use; D016853:Muromonab-CD3; D011859:Radiography
chemical_list: D000911:Antibodies, Monoclonal; D016853:Muromonab-CD3; D008775:Methylprednisolone