Reduction in band 3 protein of red cells in sickle cell anaemia.
Twelve patients suffering from sickle cell anaemia (Hb less than 75 g/l) with SS-haemoglobin were studied with special regard to Band 3-protein content in their erythrocyte membranes on SDS-PAGE. They were compared in this respect with 7 asymptomatic individuals with AS-haemoglobin and 10 healthy controls with the ordinary adult haemoglobin. A heterogeneity in Band 3-protein content was evident among the 12 patients. Six of them belonged to a low content group while the other 6 belonged to a high content group comparable with the asymptomatic subjects and the controls. No simple relationship seemed to exist between Band 3-protein reduction and the clinical presentation.
Mohamed
A O
AO
Department of Clinical Chemistry, University Hospital, Uppsala, Sweden.
Ronquist
G
G
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood*; D001457:Anion Exchange Protein 1, Erythrocyte / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D004906:Erythrocyte Count; D005260:Female; D006451:Hemoglobin, Sickle / Q000032:analysis; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012156:Reticulocytes; D012805:Sickle Cell Trait / Q000097:blood
D001457:Anion Exchange Protein 1, Erythrocyte; D006451:Hemoglobin, Sickle; C028671:hemoglobin AS