Effects of canola oil on serum lipids in humans.
Previous work in this laboratory had shown in a pilot study that canola oil could lower blood pressure and serum cholesterol levels. Attempting to extend this work to a larger cohort over a longer period, a 4-month study using a 30 ml/day addendum of canola oil as the replacement of the edible oils in the usual diet was undertaken in 36 hypercholesterolemic and/or hypertriglyceridemic subjects. Serum low-density-lipoprotein cholesterol (LDL-C) decreased from 173 +/- 9.0 to 160 +/- 10.0 mg/dl, p less than 0.025. Blood pressure, total cholesterol, and high-density-lipoprotein cholesterol (HDL-C) did not change significantly even though the HDL subfractions did, HDL2 decreasing and HDL3 increasing.
Bierenbaum
M L
ML
Kenneth L. Jordan Research Group, Montclair, New Jersey 07042.
Reichstein
R P
RP
Watkins
T R
TR
Maginnis
W P
WP
Geller
M
M
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D015331:Cohort Studies; D004910:Erythrocyte Membrane / Q000737:chemistry; D004912:Erythrocytes / Q000737:chemistry; D005227:Fatty Acids / Q000032:analysis / Q000097:blood; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry / Q000627:therapeutic use*; D015525:Fatty Acids, Omega-3 / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy*; D015228:Hypertriglyceridemia / Q000178:diet therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D000074262:Rapeseed Oil; D014280:Triglycerides / Q000097:blood; D014815:Vitamins / Q000032:analysis / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D008055:Lipids; D000074262:Rapeseed Oil; D014280:Triglycerides; D014815:Vitamins; D002784:Cholesterol