Resistance of the ME7 scrapie agent to peracetic acid.
Mouse brain infected with the ME7 strain of scrapie agent was exposed for 24 h to a range of concentrations of PAA, either as fragments of intact brain or as supernates of homogenised brain. Two % PAA inactivated the infectivity in intact tissue but not in a supernate. None of the concentrations tested (up to 19%) was effective with supernates, and this was considered to result from the protection afforded by aggregation of infectivity-containing particles.
Taylor
D M
DM
AFRC & MRC Neuropathogenesis Unit, Institute for Animal Health, Edinburgh, UK.
D000818:Animals; D001921:Brain / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D051379:Mice; D008810:Mice, Inbred C57BL; D010463:Peracetic Acid / Q000494:pharmacology*; D011328:Prions / Q000187:drug effects*
D011328:Prions; D010463:Peracetic Acid