Immune modifying effects of misoprostol and natural prostaglandins.
The synthetic prostaglandin misoprostol was found to enhance the immunosuppressive effects of cyclosporine A in vitro on human peripheral lymphocytes and mouse spleen cells, by synergizing with the latter drug, although on its own misoprostol was not potent as an immunosuppressive. These results suggest the possibility of exploiting the use of synthetic prostaglandins as adjunctive therapy in preventing clinical transplant rejection.
Iyengar
S
S
Department of Molecular and Cell Biology, G.D. Searle and Co., St. Louis, MO 63198.
Contreras
P C
PC
Mick
S J
SJ
Bremer
M E
ME
McKearn
J P
JP
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000328:Adult; D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D003524:Cyclosporins / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016595:Misoprostol; D011453:Prostaglandins / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000897:Anti-Ulcer Agents; D003524:Cyclosporins; D004338:Drug Combinations; D011453:Prostaglandins; D016595:Misoprostol; D003208:Concanavalin A; D000527:Alprostadil; D015232:Dinoprostone