[The pharmacokinetics of the marker preparations antipyrine and sulfadimezine in children suffering from bronchial asthma].
The pharmacokinetics of marker drugs antipyrine (phenazone) and sulfadimezine (sulfadimidine) was studied in 50 children with bronchial asthma and preasthmatic diseases and 6 healthy children. A decrease of antipyrine elimination rate in the patients depending on the severity, duration and phase of the disease was revealed. The specific character of xenobiotic detoxication in sick children confirms the dissociation of the functioning of the enzymatic systems of microsomal oxidation and acetylation. The necessity of the pharmacological control in bronchial asthma in children is discussed.
Ivan'ko
O G
OG
Muzylev
V V
VV
D000293:Adolescent; D000983:Antipyrine / Q000032:analysis / Q000493:pharmacokinetics*; D001249:Asthma / Q000378:metabolism*; D015415:Biomarkers / Q000737:chemistry; D001991:Bronchitis / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D012463:Saliva / Q000737:chemistry; D013418:Sulfamethazine / Q000032:analysis / Q000493:pharmacokinetics*; D013997:Time Factors
D015415:Biomarkers; D013418:Sulfamethazine; D000983:Antipyrine
Farmakokinetika markernykh preparatov antipirina i sul'fadimezina u deteĭ, stradaiushchikh bronkhial'noĭ astmoĭ.