Influence of insulin and biogenic amines on the division of Chang liver cells after primary exposure (imprinting) and repeated treatments.
Cells of the Chang liver line responded differently to insulin and histamine exposure and re-exposure after five pretreatments. The mitotic index showed a considerable relative decrease 72 h after the last pretreatment. The response to serotonin did not differ between pretreatment and re-exposure. The effect of insulin and of biogenic amines was positive at the primary exposure and negative 72 h after repeated pretreatments.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Török
O
O
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004347:Drug Interactions; D006632:Histamine / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008940:Mitotic Index / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*
D007328:Insulin; D012701:Serotonin; D006632:Histamine