Post-translational modification of lens proteins in cataract.
Evidence supporting the role of non-enzymic post-translational modification of lens proteins in cataract is reported as presented at a meeting in Bydgoszcz, Poland in August 1990. Glycation and carbamylation have been studied intensively recently. Both produce modified proteins with properties similar to those of 'molten-globule' intermediates of protein folding and unfolding pathways.
Harding
J J
JJ
Nuffield Laboratory of Ophthalmology, Oxford, UK.
D002386:Cataract / Q000378:metabolism*; D003459:Crystallins / Q000032:analysis*; D006801:Humans; D007908:Lens, Crystalline / Q000737:chemistry*; D011499:Protein Processing, Post-Translational
D003459:Crystallins