title: Characterization of the mononuclear cell infiltrate and HLA-Dr expression in 19 oligodendrogliomas.
abstract: We have studied frozen tissue from 19 oligodendrogliomas with a panel of antibodies to lymphocytes and their subsets, macrophages, natural killer cells, and HLA-Dr antigens. Macrophages were detected in moderate numbers in 60%-100% of tumors depending on the antibody used. T lymphocytes were fewer in number than macrophages and were present in 62% of cases. Most of the T lymphocytes were of the CD8 phenotype. CD4 lymphocytes were very few in number and present in only 18%. B cells and natural killer cells were absent from all cases. HLA-Dr antigens were expressed by macrophages in all cases but never on tumor cells. The implications of these findings are that macrophages and, to a lesser extent, CD8 lymphocytes are the predominant cells infiltrating oligodendrogliomas and that they may exert cellular immune functions.
authors.affiliation: Department of Neuropathology, Midland Centre for Neurology & Neurosurgery, Birmingham, Radcliffe Infirmary, Oxford, United Kingdom.
authors.forename: M L
authors.initials: ML
authors.lastname: Rossi
authors.forename: M M
authors.initials: MM
authors.lastname: Esiri
authors.forename: N R
authors.initials: NR
authors.lastname: Jones
authors.forename: H B
authors.initials: HB
authors.lastname: Coakham
authors.forename: T H
authors.initials: TH
authors.lastname: Moss
authors.forename: F F
authors.initials: FF
authors.lastname: Cruz-Sanchez
authors.forename: M P
authors.initials: MP
authors.lastname: Carey
mesh_terms: D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007694:Killer Cells, Natural; D007963:Leukocytes, Mononuclear; D008264:Macrophages; D009837:Oligodendroglioma / Q000276:immunology* / Q000473:pathology; D016176:T-Lymphocyte Subsets
chemical_list: D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens