title: Is gastroduodenitis a cause of chronic dyspepsia?
abstract: The role of Helicobacter pylori infection in causing chronic dyspepsia is in need of further clarification. More well-designed prospective studies are necessary to ascertain whether and to what extent H. pylori-related chronic inflammation in the stomach and the duodenum causes dyspeptic symptoms; whether and to what extent there is a symptom cluster characteristic for H. pylori-related gastroduodenitis; whether and to what extent H. pylori infection is demonstrable in the chronic dyspeptic population; and whether and to what extent H. pylori infection interferes with gastrin homoeostasis and acid secretion or induces motor disturbances. Well-designed prospective H. pylori-eradication studies may further contribute in unravelling its role in chronic dyspepsia, especially in patients with active polymorphonuclear gastroduodenitis and hyperacidity.
authors.affiliation: Dept. of Gastroenterology/Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: G N
authors.initials: GN
authors.lastname: Tytgat
authors.forename: L A
authors.initials: LA
authors.lastname: Noach
authors.forename: E A
authors.initials: EA
authors.lastname: Rauws
mesh_terms: D002908:Chronic Disease; D004382:Duodenitis / Q000150:complications* / Q000382:microbiology; D004415:Dyspepsia / Q000209:etiology*; D005756:Gastritis / Q000150:complications* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans