title: [The effect of perfluordecaline on the activity of phase III xenobiotic transformation enzymes].
abstract: Injection of perfluorodecaline to rats caused an increase of the phase II xenobiotic biotransformation enzyme activities followed by cytochrome P-450 induction. The activities of liver microsomal UDP-glucuronosyl transferase and glutathione transferase increased by 130 and 40%, respectively, against the control level. The increase of the cytosolic glutathione transferase activity was insignificant In contrast, the activity of sulfotransferase decreased about 2-fold. The role of modification of xenobiotic biotransformation enzymes in the biological effect of perfluorodecaline is discussed.
authors.forename: E V
authors.initials: EV
authors.lastname: Kalinina
authors.forename: V V
authors.initials: VV
authors.lastname: Obraztsov
authors.forename: D G
authors.initials: DG
authors.lastname: Shekhtman
authors.forename: O V
authors.initials: OV
authors.lastname: Gudkova
authors.forename: N I
authors.initials: NI
authors.lastname: Kukushkin
authors.forename: A N
authors.initials: AN
authors.lastname: Saprin
mesh_terms: D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D003600:Cytosol / Q000201:enzymology; D004790:Enzyme Induction; D005466:Fluorocarbons / Q000493:pharmacokinetics / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D015262:Xenobiotics / Q000493:pharmacokinetics*
chemical_list: D005466:Fluorocarbons; D015262:Xenobiotics; C008805:perfluorodecalin; D003577:Cytochrome P-450 Enzyme System; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase
vernacular_title: Vliianie perftordekalina na aktivnost' fermentov II fazy biotransformatsii ksenobiotikov.