title: [Massive osteolysis of the skull--case report and review of the literature].
abstract: The authors describe a rare case of massive osteolysis of the skull, along with a brief review of the literature. A 11 year-old female was admitted with a complaint of a painless depression in the right parietal region, which had been slowly enlarging for several years. Skull x-ray films revealed a radiolucent area with irregular and non-sclerotic margin in the right parietal bone. Plain CT showed an osteolytic lesion involving the outer table and diploë with absence of new bone formation. On 99mTc scintigrams, there were no abnormal accumulation in the whole skeletal system including the skull. Blood examinations including serum calcium, phosphate, and alkaline phosphatase were entirely normal. In the differential diagnosis of lytic skull lesion, the long, inactive course without any corroborative local or systemic evidence of illness, and the absence of new bone formation on radiological examinations clinch the diagnosis of massive osteolysis.
authors.affiliation: Department of Neurological Surgery, Hidaka General Hospital, Gobo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Nakao
authors.forename: K
authors.initials: K
authors.lastname: Kubo
authors.forename: H
authors.initials: H
authors.lastname: Moriwaki
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D002648:Child; D005260:Female; D006801:Humans; D010014:Osteolysis / Q000175:diagnosis / Q000209:etiology*; D010710:Phosphates / Q000097:blood; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging
chemical_list: D010710:Phosphates; D000469:Alkaline Phosphatase; D002118:Calcium