[Detection of homologous oncogene sequences in the genome of Plasmodium falciparum].
Homologous sequences of the acute RNA tumor virus oncogenes have been found to be highly conserved within vertebrates, insects and yeasts. In the present work, seven different oncogene DNA sequences have been used as probes to search for homologous sequences in the DNA of the protozoan Plasmodium falciparum. Both the v-fms v-Ha ras probes hybridized P. falciparum DNA. The oncogene study will allow an understanding of the biology of the parasite and particularly the host-parasite relationships which allow P. falciparum to develop, keeping the established harmony between the parasite and his host.
Macary
C
C
Département de Parasitologie-Mycologie médicale et moléculaire, La Tronche.
Chauvin
C
C
Thélu
J
J
Oury
B
B
Santoro
F
F
Ambroise-Thomas
P
P
D000818:Animals; D015342:DNA Probes; D005796:Genes / Q000235:genetics*; D016236:Genes, fms / Q000235:genetics*; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D010963:Plasmodium falciparum / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D015342:DNA Probes
Détection de séquences homologues d'oncogènes dans le génome de Plasmodium falciparum.