Electrophysiological evidence that morphine can exert an antinociceptive effect in a neuropathic state: a study in the ventrobasal thalamus of rats after moderate ligation of one sciatic nerve.
This study was performed in rats with a mononeuropathy induced by loose ligatures around the common sciatic nerve 2 weeks before the recording session, and exhibiting clear alterations of several pain-related behaviours. Morphine injected intravenously (0.6 and 1 mg/kg) strongly depressed the ventrobasal thalamic neuronal responses to pinch applied to the lesioned or the non-lesioned hindpaw. The effect, comparable on the both sides, was dose-related and reversed by naloxone (0.1 mg/kg i.v.).
Guilbaud
G
G
Institut National de la Santé et de la Recherche Médicale, U.161, Paris, France.
Benoist
J M
JM
Gautron
M
M
D000704:Analysis of Variance; D000818:Animals; D004594:Electrophysiology; D005528:Foot / Q000503:physiopathology; D008026:Ligation; D009020:Morphine / Q000494:pharmacology*; D009422:Nervous System Diseases / Q000503:physiopathology*; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve; D013788:Thalamus / Q000187:drug effects / Q000503:physiopathology*
D009020:Morphine