(-) deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats.
Daily s.c. injection of (-)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furthermore, the activity of catalase (but not of glutathione peroxidase) was also increased significantly by deprenyl treatment. The results confirmed the previous findings of Knoll on SOD activity and furthermore provided evidence that the activity of catalase is also significantly induced by the drug, which was not found in the previous study.
Carrillo
M C
MC
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
Kanai
S
S
Nokubo
M
M
Kitani
K
K
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D007536:Isomerism; D007700:Kinetics; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012016:Reference Values; D012642:Selegiline / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism*
D012642:Selegiline; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase