Enhanced contractile effect of phorbol dibutyrate in portal veins from hypertensive rats.
The effects of phorbol 12,13-dibutyrate (PDBu) on portal veins from hypertensive (SHRSP0 and normotensive (WKY) rats were examined. PDBu contracted the strips from SHRSP and WKY in a concentration-dependent manner. However, both twitch contraction and tonic contraction of strips in response to PDBu were enhanced in SHRSP. Treatment with staurosporine reduced contractile response to PDBu in strips from SHRSP. It appears that the activity of protein kinase C in vascular smooth muscle is increased in SHRSP.
Miyata
N
N
Research Center, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.
Tsuchida
K
K
Otomo
S
S
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004533:Egtazic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D009543:Nifedipine / Q000494:pharmacology; D015240:Phorbol 12,13-Dibutyrate / Q000494:pharmacology*; D011169:Portal Vein / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D019311:Staurosporine
D000470:Alkaloids; D015240:Phorbol 12,13-Dibutyrate; D004533:Egtazic Acid; D019311:Staurosporine; D009543:Nifedipine