Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).
We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-rat somatic cell hybrids with different contents of human chromosomes. From these data we were able to assign DGI to chromosome 18 (DSG), DGII/III to chromosome 9p (DSC), DPI/II to chromosome 6p21-ter(DSP), and DPIII to chromosome 7 (JUP).
Arnemann
J
J
Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, United Kingdom.
Spurr
N K
NK
Wheeler
G N
GN
Parker
A E
AE
Buxton
R S
RS
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D002896:Chromosomes, Human, Pair 6; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D003598:Cytoskeletal Proteins / Q000235:genetics*; D051187:Desmocollins; D051182:Desmogleins; D051180:Desmoplakins; D003896:Desmosomes; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D051381:Rats; D051185:gamma Catenin
D003598:Cytoskeletal Proteins; C495294:DSP protein, human; D051187:Desmocollins; D051182:Desmogleins; D051180:Desmoplakins; C495295:Dsp protein, mouse; D051185:gamma Catenin