Effects of diltiazem on postischaemic renal cortical microcirculation in the pig.
Diltiazem--a calcium entry blocker--was tested in a porcine model under continuous chlormethiazole-pancuronium anaesthesia as protection against renal failure following 60 min of renal ischaemia. Fourteen pigs were randomly allocated to one experimental (diltiazem and ischaemia) and one control group (only ischaemia) (n = 7 in each). Diltiazem was administered as a continuous intravenous infusion started before the ischaemic insult. In two additional animals diltiazem was given but ischemia was not induced. The postischaemic renal cortical microcirculation was simultaneously investigated in four different regions in the left kidney during the first 4 h of reperfusion. Laser Doppler flowmetry (LDF) was performed in two different regions and measurement of tissue oxygenation was done in two other regions. In the two animals treated with diltiazem without ischaemia, only minor variations in central haemodynamic and renal microcirculatory parameters were evident. In the control group (ischaemia), superficial renal cortical blood flow (Qsrc) decreased from 49 +/- 11 (s.d.) arbitrary units at baseline to 24 +/- 4 arb. units 4 h after start of reperfusion (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Sandin
R
R
Department of Anaesthesiology and Intensive Care, University Hospital, Uppsala, Sweden.
Feuk
U
U
Wahlberg
J
J
Modig
J
J
D058186:Acute Kidney Injury / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D004110:Diltiazem / Q000627:therapeutic use*; D005260:Female; D007511:Ischemia / Q000150:complications*; D007672:Kidney Cortex / Q000098:blood supply*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D013552:Swine
D004110:Diltiazem