[The effect of nimodipine and verapamil on the blood supply and vascular reactivity of the brain].
In experiments on conscious rabbits with electrodes implanted into the brain it was found by using hydrogen clearance method that nimodipine (0.1-0.06 mg/kg) and verapamil (0.3-1 mg/kg) increase the local blood flow to the decreasing degree in the cerebral hemispheric cortex, hypothalamus and thalamus. This is associated with a decrease in reactivity of the vessels of the above mentioned brain structures determined by the dilatory reaction to the dosed inhalation of carbon dioxide.
Beketov
A I
AI
Polevik
I V
IV
D000280:Administration, Inhalation; D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage; D002536:Cerebral Arteries / Q000187:drug effects* / Q000502:physiology; D002550:Cerebral Veins / Q000187:drug effects* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004567:Electrodes, Implanted; D009553:Nimodipine / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology; D014700:Verapamil / Q000494:pharmacology*
D002245:Carbon Dioxide; D009553:Nimodipine; D014700:Verapamil
Vliianie nimodipina i verapamila na krovosnabzhenie i reaktivnost' sosudov golovnogo mozga.