title: Influence of ileal resection, type of diet and ursodeoxycholic acid on biliary secretion in rats.
abstract: We studied the effects of the type of dietary fat and of ursodeoxycholic acid, an exogenous bile acid added to the diet, on bile physiology in rats with 50% resection of the distal small intestine. The amount of fat was the same (4%) in all diets assayed, which differed only in the type of fat, (olive oil in diet A, and 1/3 medium-chain triglycerides, 1/3 sunflower oil and 1/3 olive oil in diet B). The removal of 50% of the distal small intestine raised the de novo hepatic synthesis of bile acids with respect to controls, regardless of whether diet A or diet B was given. The addition to diet B of ursodeoxycholic acid decreased bile flow and osmotic activity of bile acid in resected rats and raised bile acid-independent bile flow in comparison to resected rats given diet B without ursodeoxycholic acid.
authors.affiliation: Departamento de Fisiología, Facultad de Farmacia, Universidad de Granada, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Lisbona
authors.forename: M S
authors.initials: MS
authors.lastname: Campos
authors.forename: F
authors.initials: F
authors.lastname: Coves
authors.forename: J A
authors.initials: JA
authors.lastname: García
authors.forename: M
authors.initials: M
authors.lastname: Barrionuevo
authors.forename: I
authors.initials: I
authors.lastname: López-Aliaga
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D007082:Ileum / Q000502:physiology / Q000601:surgery; D007581:Jejunoileal Bypass; D008099:Liver / Q000378:metabolism; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D014580:Ursodeoxycholic Acid / Q000494:pharmacology*
chemical_list: D001647:Bile Acids and Salts; D004041:Dietary Fats; D014580:Ursodeoxycholic Acid