Human, pig and guinea-pig bladder smooth muscle cells generate similar inward currents in response to purinoceptor activation.
The contribution of purinergic neurotransmission to bladder excitation in pigs and man is small. Exogenously-applied adenosine-trisphosphate (ATP) however, elicits large inward currents in dispersed bladder smooth muscle cells in both species. The essential properties of the ATP-induced current in human and pig detrusor are similar and the current intensity is comparable to those in the guinea-pig, which has a powerful purinergic excitatory innervation. This suggests that other features of the tissue such as the closeness of the innervation and the degree of cell-to-cell coupling may be important in determining the effectiveness of purinergic transmission.
Inoue
R
R
University Department of Pharmacology, Oxford.
Brading
A F
AF
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000502:physiology; D011983:Receptors, Purinergic / Q000502:physiology*; D013552:Swine; D001743:Urinary Bladder / Q000294:innervation*
D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate