[Glutamate dehydrogenase activity in the pancreatic tissue in acute experimental pancreatitis and under the action of sodium thiosulphate].
It has been established that the development of acute pancreatitis is accompanied by the reduced activity of glutamate dehydrogenase in the mitochondrial fraction of pancreas, pronounced in the focus of tissue necrosis and less expressed in the reactive inflammation focus. Besides this in the pancreas redistribution of enzyme, activity in the subcellular organelles takes place and enzyme activity emerges in the cytosol and further--in the blood and peritoneum liquid. Sodium thiosulfate has a marked correlation effect.
Simavorian
P S
PS
Saakian
I L
IL
Gevorkian
D A
DA
D000208:Acute Disease; D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002614:Chelating Agents / Q000494:pharmacology*; D005969:Glutamate Dehydrogenase / Q000032:analysis*; D008928:Mitochondria / Q000201:enzymology; D015388:Organelles / Q000201:enzymology; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D010195:Pancreatitis / Q000201:enzymology*; D051381:Rats; D013885:Thiosulfates / Q000494:pharmacology*
D000931:Antidotes; D000975:Antioxidants; D002614:Chelating Agents; D013885:Thiosulfates; D005969:Glutamate Dehydrogenase; C017717:sodium thiosulfate
Aktivnost' glutamatdegidrogenazy v tkani podzheludochnoĭ zhelezy pri ostrom éksperimental'nom pankreatite i pod vliianiem tiosul'fata natriia.