Structural alterations of p(HEMA)--collagen implants.
Samples of linear (additionally crosslinked) p(HEMA) with different amounts of fibrillar collagen were implanted into the popliteal region of rats. After 3 month, the implanted materials were harvested and examined by SEM. The implants underwent marked structural or morphological changes. While the fibrillar collagen was readily resorbed by invading cells, the synthetic constituent persisted to biodegradation. The p(HEMA) residues were shaped into spherical particles, approx. 1-15 microns in diameter. The possible fate of these microparticles in the host organism is discussed.
Stol
M
M
Research Institute for Rheumatic Diseases, Prague, Czechoslovakia.
Cífková
I
I
Tyrácková
V
V
Adam
M
M
D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D003094:Collagen / Q000648:ultrastructure*; D003188:Composite Resins; D007866:Leg; D008297:Male; D008855:Microscopy, Electron, Scanning; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry*; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains
D001672:Biocompatible Materials; D003188:Composite Resins; D011102:Polyhydroxyethyl Methacrylate; D003094:Collagen