Synthesis and antifungal activity of some new benzimidazole derivatives.
Synthesis and antifungal evaluation of 5-ethoxycarbonyl-2-(substituted-benzyl or phenoxymethyl)benzimidazoles are reported. Structures of the compounds were elucidated with IR-, 1H-NMR-, 13C-NMR-, mass-spectra and elemental analysis. Preliminary results show that none of the synthesized benzimidazole derivatives has antifungal activity at the concentration of 100 micrograms/ml against Candida parapsilosis, Candida stellatoidea, and Candida pseudotropicalis.
Göker
H
H
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara, Turkey.
Ertan
R
R
Akgün
H
H
Yulug
N
N
D000935:Antifungal Agents / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D001562:Benzimidazoles