Serum time curve characteristics of a fixed dose of beta-carotene in young and old men.
The present study was designed to evaluate age-related differences in serum beta-carotene time curve response characteristics when a beta-carotene dose was given in conjunction with 1500 kcal over the course of a day. On two consecutive days, seven old (73 +/- 4 years) and six young (24 +/- 1 years) men were each fed three 500-kcal meals of an isotonic liquid formula diet containing only trace amounts of beta-carotene. On the first day of testing, no supplemental beta-carotene was given (baseline day). A 15 mg dose of beta-carotene was fed with the morning meal on the second day (test dose day). Fasting blood and hourly blood samples were obtained for 8 consecutive hours on both days. Additional blood was drawn 24 and 48 hours after the test beta-carotene dose. There were no statistical differences in baseline beta-carotene concentrations between the two age groups tested, but, because of high individual variability, serum time curve characteristics were adjusted for fasting beta-carotene levels. After adjustment, the postdose serum beta-carotene response was two to three times greater (p less than or equal to 0.04) in young subjects, as evaluated by peak concentration, area under the curve, or ascending slope of the serum response curve. Examination of factors besides age group that may have accounted for these results suggests that the serum response of the elderly may be more a function of body composition and/or serum lipid patterns than of age per se. However, in the present US population, it may not be valid to control for these factors, which are both closely related to aging.
Sugerman
S B
SB
Department of Medicine, School of Public Health, University of Illinois, Chicago.
Mobarhan
S
S
Bowen
P E
PE
Stacewicz-Sapuntzakis
M
M
Langenberg
P
P
Henderson
C
C
Kiani
R
R
Friedman
H
H
Lucchesi
D
D
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000378:metabolism*; D000704:Analysis of Variance; D000886:Anthropometry; D001798:Blood Proteins / Q000032:analysis; D001823:Body Composition; D002338:Carotenoids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004224:Diterpenes; D004305:Dose-Response Relationship, Drug; D004435:Eating; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D012176:Retinoids / Q000097:blood; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives / Q000097:blood; D019207:beta Carotene
D001798:Blood Proteins; D004224:Diterpenes; D008055:Lipids; D012176:Retinoids; D000084562:Retinyl Esters; D019207:beta Carotene; D014801:Vitamin A; C014794:retinol palmitate; D002338:Carotenoids