Prenatal nicotine exposure increased susceptibility to electroconvulsive shock (ECS) in adult rats.
Female rats were treated during pregnancy (days 1-20) with nicotine (1 mg/kg SC, b.i.d.). When some aspects of maternal behavior and developmental parameters were recorded in mothers and pups, respectively, no changes were detected in the experimental group as compared with controls. However, adult offspring of nicotine-treated rats showed an increased susceptibility to ECS. These results demonstrate long-lasting deleterious effects induced by nicotine exposure during fetal life.
Britos
S A
SA
Departamento de Farmacología, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba, Argentina.
Orsingher
O A
OA
D000818:Animals; D004597:Electroshock; D005260:Female; D005333:Fetus / Q000187:drug effects; D008297:Male; D008425:Maternal Behavior; D008431:Maternal-Fetal Exchange; D009538:Nicotine / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012018:Reflex / Q000187:drug effects; D012640:Seizures / Q000503:physiopathology*; D012744:Sex Ratio
D009538:Nicotine