[Effects of food restriction on the protein and electrolyte composition in the liver and muscles of rats].
Protein and electrolyte disturbances in hepatic and muscle tissues are related to trauma, sepsis, or short term starvation or semistarvation. The consequences of a prolonged semistarvation are poorly understood. For five weeks, male adult rats were offered 50% of the diet until they had a weight loss of 40%, after which protein and electrolyte (Ca++, Mg++, Zn++, Na+, K+) changes in the liver and soleus and extensorum digitorum longus muscles were analyzed. There was a significant weight loss after 5 weeks of semistarvation. Hepatic protein and serum albumin were not changed, but the authors observed a significant muscle protein depletion. A fall in Zn++ levels in the blood was accompanied by a rise in muscle and liver concentrations. The rise in Ca++ and Mg++ concentration in blood and in the muscles might be related to the enhanced proteolysis. Results suggest that the early changes of protein and electrolyte metabolism at tissue level with semistarvation impair muscular and hepatic functions as they delay adequate response to trauma and infection.
Ponzoni
M E
ME
Depto. de Cirurgia, FCMSC, São Paulo.
Curi
R
R
Boeck-Haebisch
E M
EM
da Costa
A C
AC
Franco
S
S
Fernandes
L C
LC
Rasslan
S
S
D000818:Animals; D004044:Dietary Proteins / Q000032:analysis*; D004573:Electrolytes / Q000032:analysis*; D005508:Food Deprivation / Q000502:physiology*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000378:metabolism* / Q000473:pathology; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains
D004044:Dietary Proteins; D004573:Electrolytes; D009124:Muscle Proteins
Efeitos da restrição alimentar sobre a composição protéica e eletrolítica hepática e muscular de ratos.