The effect of prostaglandins and aspirin--an inhibitor of prostaglandin synthesis--on adhesion formation in rats.
The effect of intraperitoneal application of prostaglandins E2 and F2 alpha and of aspirin, a non-steroidal anti-inflammatory drug, on the formation of intraperitoneal adhesions was investigated in rats, in view of the main role of the body's reaction in adhesion formation. Intraperitoneal adhesions were induced by inflicting uniform trauma to the uterine serosa. It was demonstrated that prostaglandin E2 may increase adhesion formation and that intraperitoneal aspirin is able to inhibit its formation.
Golan
A
A
Department of Obstetrics and Gynaecology, Serlin Maternity Hospital, Hakirya, Tel Aviv, Israel.
Bernstein
T
T
Wexler
S
S
Neuman
M
M
Bukovsky
I
I
David
M P
MP
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors; D015237:Dinoprost / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005260:Female; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D000267:Tissue Adhesions / Q000517:prevention & control; D014591:Uterine Diseases / Q000517:prevention & control*
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D015237:Dinoprost; D015232:Dinoprostone; D001241:Aspirin