[Hemodynamic effects of captopril in acute infarct of the anterior myocardium].
OBJECTIVE
Evaluation of haemodynamic effects after sublingual administration of 25 mg of captopril in patients with Acute Anterior Myocardial Infarction within the first 48 hours.


METHODS
Determination of basal parameters and 30 minutes after 25 mg of captopril.


METHODS
Patients admitted in the ICU with Anterior Myocardial Infarction diagnosis.


METHODS
41 consecutive patients; 22 patients submitted to thrombolysis with streptokinase; 19 patients submitted to conventional therapy.


RESULTS
A) In the whole group: No significant change in the HR, PAP, CI, SI, MAP, SVR, PR. RA and CWP were reduced. B) In thrombolysed patients: No significant change in HR, RA, PAP, CWP, MAP, SVR, PR. CI and SI were significantly increased. C) In non-thrombolysed patients: No significant change in HR, PAP, CI, SI, SVR, PR. RA, CWP and MAP were reduced.


CONCLUSIONS
1. We found no significant hypotension with sublingual captopril in Acute Myocardial Infarction. 2. Non-thrombolysed patients showed a greater reduction of arterial pressure. 3. Thrombolysed patients had significant increases in systolic function indices.
Mourão
L
L
UCIM, Hospital de São Francisco de Xavier, Lisboa.
Santos
J M
JM
Neves
J L
JL
Lema-Santos
A
A
Sales-Luís
A
A
D000286:Administration, Sublingual; D000368:Aged; D002216:Captopril / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*
D002216:Captopril
Efeitos hemodinâmicos do captopril no enfarte agudo do miocárdio anterior.