title: [From nucleic acids to proteins].
abstract: Since elucidation of structure of deoxyribonucleic acid (DNA) as genetic material, it was established that DNA makes ribonucleic acid, which makes protein according to the original information given in DNA base as base sequences. From these basic idea of genetic flow system there was emerged the word "protein engineering". According to this principle, engineering of h-lysozyme, RNase H and their relevant proteins was described. A triosephosphate isomerase barrel type protein was designed and expressed.
authors.affiliation: Protein Engineering Research Institute, Suita, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ikehara
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009113:Muramidase / Q000502:physiology; D010455:Peptides / Q000138:chemical synthesis / Q000235:genetics; D011487:Protein Conformation; D015202:Protein Engineering; D006163:Ribonuclease T1 / Q000235:genetics / Q000502:physiology
chemical_list: D010455:Peptides; D004247:DNA; D006163:Ribonuclease T1; D009113:Muramidase