Fever and acute-phase response induced in rabbits by intravenous and intracerebroventricular injection of interleukin-6.
We investigated the effect of human recombinant interleukin-6 (IL-6) on body temperature and acute-phase response, including changes in plasma levels of iron, zinc, copper, and fibrinogen and in circulating leukocyte count. The intravenous (IV) injection of IL-6 (2 micrograms/kg) produced a monophasic fever. The intracerebroventricular (ICV) injection of IL-6 produced a dose-dependent fever that developed gradually and remained elevated throughout the 5-h recording period. The IV injection of IL-6 decreased the plasma concentration of iron and zinc and increased the circulating leukocyte count. The ICV injection of IL-6 resulted in similar trace metal and leukocyte changes, and increased plasma levels of fibrinogen. These results show that IL-6 can cause fever when injected IV or ICV and induces some acute-phase responses through its action on peripheral target organs and in the central nervous system.
Sakata
Y
Y
Department of Physiology, Yamaguchi University School of Medicine, Japan.
Morimoto
A
A
Long
N C
NC
Murakami
N
N
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D003300:Copper / Q000097:blood; D004906:Erythrocyte Count / Q000187:drug effects; D005334:Fever / Q000097:blood / Q000139:chemically induced*; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D015850:Interleukin-6 / Q000008:administration & dosage / Q000494:pharmacology*; D007501:Iron / Q000097:blood; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D011817:Rabbits; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D015032:Zinc / Q000097:blood
D015850:Interleukin-6; D011994:Recombinant Proteins; D003300:Copper; D005340:Fibrinogen; D007501:Iron; D015032:Zinc