title: [Histologic study of the effect of postoperative irradiation on free transplanted jejunal segments].
abstract: After the reconstruction of defects resulting from the resection of advanced tumors from the upper aerodigestive tract using free microvascular anastomized jejunum, the autotransplant is influenced by local radiotherapy (cumulative dose 50-70 Gray). Biopsies were taken from 15 patients, stained with haemotoxilin-eosin and Giemsa and compared by means of light microscopy with jejunum taken at the time of transplantation. It was possible to observe a widened mucosal and submucosal space two to three months after radiotherapy, similar to the clinical impression of a radiogenic enteritis. The villi were flat and shortened with no or slight epithelial lesions. Additionally, it was possible to observe an inflammatory infiltration consisting mainly of neutrophilic granulocytes, edemas, and telangiectases. The latter were also evident in nonirradiated autotransplanted jejunum and are therefore not only caused by irradiation. One year after radiotherapy the mucosal membrane was atrophic. Fibrosis was to be seen in the lamina propria, accompanied by widened muscularis mucosae. The submucosal space was also widened and fibrotic to a varying degree. It was possible to detect varying stages of alteration in the vascular system up to a complete obliteration. After two years, changes were more pronounced. At no time could any alteration in the nervous system of the plexus submucosus be observed. All of these changes have to be interpreted as a consequence of irradiation. However, lubrication of the mucosal surface and the motility of the transplant are not altered severely by irradiation and therefore the desired functions of the free transplanted jejunal grafts, such as swallowing and phonation, are carried out sufficiently.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: 1. HNO-Universitätsklinik, Wien, Osterreich.
authors.forename: M C
authors.initials: MC
authors.lastname: Grasl
authors.forename: J
authors.initials: J
authors.lastname: Kornfehl
authors.forename: C
authors.initials: C
authors.lastname: Neuchrist
authors.forename: K
authors.initials: K
authors.lastname: Ehrenberger
authors.forename: H
authors.initials: H
authors.lastname: Piza
authors.forename: R
authors.initials: R
authors.lastname: Roka
authors.forename: O
authors.initials: O
authors.lastname: Braun
authors.forename: C
authors.initials: C
authors.lastname: Stanek
mesh_terms: D001706:Biopsy; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006085:Graft Survival / Q000528:radiation effects; D006801:Humans; D007583:Jejunum / Q000473:pathology / Q000528:radiation effects / Q000637:transplantation*; D010039:Otorhinolaryngologic Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D011183:Postoperative Complications / Q000473:pathology*; D011832:Radiation Injuries / Q000473:pathology*; D011879:Radiotherapy Dosage
vernacular_title: Histologische Studie über den Einfluss der postoperativen Bestrahlung auf frei transplantierte Jejunalsegmente.