Reductive activation of N-oxides to cause DNA strand breakage in cell lines in vitro.
Cahill
A
A
MRC Toxicology Unit, Carshalton, Surrey.
White
I N
IN
D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002279:Carcinoma 256, Walker; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004249:DNA Damage; D004261:DNA Replication / Q000187:drug effects / Q000528:radiation effects; D007700:Kinetics; D008466:Mechlorethamine; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D000077704:Tirapazamine; D014227:Triazines / Q000494:pharmacology*
D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; D014227:Triazines; D000077704:Tirapazamine; D008466:Mechlorethamine; D013936:Thymidine