[Immune disorders and sensitization to microbial antigens in seronegative spondylitis].
A study was made of immunity in seronegative spondylarthritis. In ankylosing spondylarthritis, reactive arthritides and psoriatic arthritis, the decrease of T cells, T helpers and T suppressors was identified. Patients with ankylosing spondylarthritis and reactive arthritides manifested an increase of the B-lymphocyte count. Patients with ankylosing spondylarthritis were demonstrated to be sensitive to Klebsiella (52%), those with reactive arthritides to intestinal yersinia (44%). The phenotype of antigen-binding cells was examined. Of these, 39% appeared to be T lymphocytes, 29% B lymphocytes. The presence of Fc receptors in an appreciable portion of those cells suggests their functional maturity. The inhibition test demonstrated the participation of HLA-B27 in reception of Klebsiella antigens in ankylosing spondylarthritis.
Davtian
V G
VG
Garib
F Iu
FIu
Belen'kiĭ
A G
AG
Saliev
T S
TS
D000942:Antigens, Bacterial / Q000276:immunology*; D001170:Arthritis, Infectious / Q000276:immunology; D015535:Arthritis, Psoriatic / Q000276:immunology; D016918:Arthritis, Reactive / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D015796:HLA-B27 Antigen / Q000276:immunology; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology*; D007114:Immunization; D007711:Klebsiella pneumoniae / Q000276:immunology*; D007958:Leukocyte Count; D013167:Spondylitis, Ankylosing / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D015008:Yersinia enterocolitica / Q000276:immunology*
D000942:Antigens, Bacterial; D015796:HLA-B27 Antigen
Immunnye narusheniia i sensibilizatsiia k mikrobnym antigenam pri seronegativnykh spondyloartritakh.