[Conjunctival microcirculation and hemorheology in patients with venous occlusions of the retina].
Forty-two patients with branch vein or central retinal vein occlusion were enrolled in this randomized placebo-controlled study. We studied the influence of hemodilution therapy with hydroxyethyl-starch (HAES-steril) combined with pentoxifylline (Trental) for 6 months. In the bulbar conjunctiva, capillary red blood cell (RBC) velocities and vessel diameters and rheological parameters of hematocrit, erythrocyte aggregation and plasma viscosity were examined. In the hemodilution group we observed no changes in vessel diameter and a significant increase in RBC velocity after therapy. After 6 weeks the RBC velocity showed 30% higher values but there was no statistically significant difference. After hemodilution therapy hematocrit, erythrocyte aggregation and plasma viscosity were significantly different from those in the control group. After 6 weeks we observed significant differences only in erythrocyte aggregation. This examination verifies the positive influence of hemodilution therapy on microcirculation and hemorheology.
Arend
O
O
Augenklinik, Medizinischen Fakultät der RWTH, Aachen, Bundesrepublik Deutschland.
Wolf
S
S
Schulte
K
K
Jung
F
F
Bertram
B
B
Reim
M
M
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D003228:Conjunctiva / Q000098:blood supply*; D005260:Female; D006438:Hemodilution; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D011446:Prospective Studies; D012170:Retinal Vein Occlusion / Q000503:physiopathology* / Q000628:therapy; D012212:Rheology
Konjunktivale Mikrozirkulation und Hämorheologie bei Patienten mit venösen Verschlüssen der Retina.