Hepatitis C virus infection in patients with chronic liver diseases.
Antibodies against hepatitis C (HCV) in 512 patients were measured by an enzyme immunoassay (Ortho-HCV ELISA). The frequency of anti-HCV was 80%, 86%, 85% in nonB (NB) chronic hepatitis (CH), cirrhosis (LC), hepatocellular carcinoma (HCC), respectively; 70%, 90% in alcoholic (AL) LC, HCC; 15%, 33%, 58% in hepatitis B (HB) CH, LC, HCC, respectively. Anti-HCV positive cirrhotics had a shorter survival time and earlier development of HCC than anti-HCV negative cirrhotics. The findings suggest that HCV is a major cause of NB chronic liver diseases and may play a pathogenetic role in AL and HB liver diseases.
Yoshikawa
M
M
Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan.
Tsujii
T
T
Fukui
H
H
Yamao
J
J
Tsukamoto
N
N
Nishimura
N
N
Kyo
M
M
Takaya
A
A
Tsujii
H
H
Nakano
H
H
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000453:epidemiology*; D006801:Humans; D008107:Liver Diseases / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies
D006508:Hepatitis Antibodies