title: Isochromosome 21q in hematologic malignancies. Groupe Français de Cytogénétique Hématologique.
abstract: Isochromosome(21q) is a rare but non-random karyotypic change in hematologic diseases. We report 15 cases of i(21q) among a large group of cases, in various disorders of both myeloid and lymphoid lineage. This abnormality has been found as the sole chromosome change in two cases, the remaining cases exhibiting more or less complex karyotypes. Finally we discuss the labelling "i(21q)".
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006402:Hematologic Diseases / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D016609:Neoplasms, Second Primary; D011878:Radiotherapy / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents