Autologous keratinocyte grafting: a new technique for intra-oral reconstruction.
Oral keratinocytes have been grown in sheets in the laboratory from small oral biopsies from four patients undergoing reconstructive oral surgery. These sheets have been successfully applied to mucosal surfaces and good clinical results obtained, with accelerated healing of mucosal defects. These results indicate that keratinocyte grafts can be used in mucosal sites, and may have applications as an alternative to skin grafts in the mouth.
Langdon
J
J
Department of Oral and Maxillofacial Surgery, King's College School of Medicine and Dentistry, London.
Williams
D M
DM
Navsaria
H
H
Leigh
I M
IM
D000368:Aged; D002291:Carcinoma, Papillary / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D002478:Cells, Cultured; D002648:Child; D002971:Cleft Lip / Q000601:surgery; D002972:Cleft Palate / Q000601:surgery; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000637:transplantation*; D008297:Male; D008441:Maxillary Neoplasms / Q000601:surgery; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology / Q000601:surgery*; D010157:Palatal Neoplasms / Q000601:surgery; D013526:Surgical Mesh