title: Dystrophin in control and mdx retina.
abstract: To determine whether or not dystrophin really exists in the outer plexiform layer (OPL) of the retina, we studied control and mdx mice, using four kinds of polyclonal antibodies (DMDP-II, 60 kd, 30 kd and DMDP-IV) against dystrophin. Although control OPL showed a positive immunohistochemical reaction with all four antibodies, mdx OPL showed a positive reaction with DMDP-II and DMDP-IV, a negative reaction with 60 kd and 30 kd antibodies. Immunoblot analysis showed the positive band compatible with the immunohistochemical reaction.
authors.affiliation: Division of Child Development, Kumamoto University Medical School, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Zhao
authors.forename: M
authors.initials: M
authors.lastname: Uchino
authors.forename: K
authors.initials: K
authors.lastname: Yoshioka
authors.forename: M
authors.initials: M
authors.lastname: Miyatake
authors.forename: T
authors.initials: T
authors.lastname: Miike
mesh_terms: D000818:Animals; D016189:Dystrophin / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D015151:Immunoblotting; D051379:Mice; D008818:Mice, Neurologic Mutants; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D012160:Retina / Q000737:chemistry*
chemical_list: D016189:Dystrophin