Lead acetate delays rapid postnatal mouse brain and body growth.
Starting at parturition and continuing until weaning, mothers of five mouse litters received tap water while five others had 10 mg PbAc/ml in their drinking water. The offspring receiving lead from the mothers had significantly lower body weights after the first days of receiving lead; their slowed body growth led to a 2-day delay of onset (usually at 16-18 days) of their last rapid body growth stage. They also had significantly smaller brain weights between age 14 days and weaning (23 days). The onset of rapid brain growth was delayed from its usual onset at 16-18 days to about 22-23 days before rising to about the same value as the control mice at 26 days. Thus, the initial effect on brain growth is decidedly greater than on body growth, though brain weight later reaches close to the control value.
Epstein
H T
HT
Biology Department, Brandeis University, Waltham, MA 02254.
Fenton
K
K
Shimpach
S
S
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000254:growth & development; D005260:Female; D006128:Growth / Q000187:drug effects*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D009942:Organometallic Compounds / Q000494:pharmacology*
D009942:Organometallic Compounds; C008261:lead acetate