title: Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).
abstract: We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-rat somatic cell hybrids with different contents of human chromosomes. From these data we were able to assign DGI to chromosome 18 (DSG), DGII/III to chromosome 9p (DSC), DPI/II to chromosome 6p21-ter(DSP), and DPIII to chromosome 7 (JUP).
authors.affiliation: Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Arnemann
authors.forename: N K
authors.initials: NK
authors.lastname: Spurr
authors.forename: G N
authors.initials: GN
authors.lastname: Wheeler
authors.forename: A E
authors.initials: AE
authors.lastname: Parker
authors.forename: R S
authors.initials: RS
authors.lastname: Buxton
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D002896:Chromosomes, Human, Pair 6; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D003598:Cytoskeletal Proteins / Q000235:genetics*; D051187:Desmocollins; D051182:Desmogleins; D051180:Desmoplakins; D003896:Desmosomes; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D051381:Rats; D051185:gamma Catenin
chemical_list: D003598:Cytoskeletal Proteins; C495294:DSP protein, human; D051187:Desmocollins; D051182:Desmogleins; D051180:Desmoplakins; C495295:Dsp protein, mouse; D051185:gamma Catenin