[The dose-response relationship for indices of the micronucleus test using neutron-spectra therapeutic irradiation].
It was shown by method of cytokinetic blocking that with neutron irradiation of human lymphocyte culture (mean energy of 0.85 MeV, doses of 0.05 to 2 Gy) the dose-response relationship, with respect to the share of binuclear cells with micronuclei and the frequency of micronuclei in binuclear cells, was of a multiphase nature with a more or less manifest plateau within the dose-range from 0.5 to 1.0 Gy. Both micronuclear tests may be used for indicating the degree of radiation injury to the organism caused by neutrons of the above-mentioned energy and doses of 0.05-0.5 Gy.
Ankina
M A
MA
Mikhaĭlova
G F
GF
Filimonov
A S
AS
D000328:Adult; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D015162:Micronucleus Tests; D009502:Neutrons
Izuchenie zavisimosti doza-éffekt dlia pokazateleĭ mikroiadernogo testa pri ispol'zovanii oblucheniia neĭtronami spektra lecheniia.