[Studies on decomposition kinetics of thalidasine in aqueous solution].
In this report, the decomposition kinetics of thalidasine (TD) in aqueous solution at pH 2.0-7.8, salt concentration 0-0.132 mol/L, temperature 50, 60, 70, 80 degrees C, and different oxygen concentrations were investigated. The decomposition rate constant of TD in aqueous solution were determined by fluorescence spectrophotometer. The results showed: the oxidation reaction contributed largely to the overall decomposition, the oxidation rate of TD was found to be chiefly dependent on the PH of the medium and presence of oxygen. When in excess oxygen, the reaction followed pseudo first-order kinetics with respect to TD concentration. The rate constant can be expressed as: [formula: see text]. No primary salt effect was observed at pH 7.2.
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Shenyang College of Pharmacy.
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D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D044182:Benzylisoquinolines; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008433:Mathematics; D010084:Oxidation-Reduction; D010100:Oxygen; D012996:Solutions
D000972:Antineoplastic Agents, Phytogenic; D044182:Benzylisoquinolines; D012996:Solutions; C057069:thalidasine; D010100:Oxygen