New heterocyclic derivatives of benzimidazole with germicidal activity--IX--HPLC detection of 5-fluoro-2-(5'-nitro-2'-furyl)benzimidazole (F-O-NO2) in biological samples.
The HPLC technique for the isolation and quantitation of 5-fluoro-2-(5'-nitro-2'-furyl)benzimidazole (F-O-NO2), previously described by the same Authors, in biological samples from mice is reported. Evidence is given that the highest biological concentration and the time needed for reaching it depend both on the dose and on the administration route. In fact, almost the same maximal biological concentration of F-O-NO2 (about 0.18 micrograms/mouse) is reached after 60 min from either 40 mg/Kg IP or 200 mg/Kg os drug administration, whereas the maximal biological concentration of F-O-NO2 (5.75 micrograms/mouse) is reached after 30 min from 120 mg/Kg IP drug administration.
Pedini
M
M
Istituto di Biochimica e Chimica Medica, Univerisità Degli Studi di Perugia, Italia.
Bistocchi
G A
GA
De Meo
G
G
Ricci
A
A
Bastianini
L
L
Cipiciani
A
A
Rossi
L
L
D000818:Animals; D000890:Anti-Infective Agents / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics; D001562:Benzimidazoles / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D008297:Male; D051379:Mice; D009929:Organ Size; D014018:Tissue Distribution
D000890:Anti-Infective Agents; D001562:Benzimidazoles; C042757:5-fluoro-(2'-nitrofuryl)-2-benzimidazole