title: Cocaine treatment in neonatal rats affects the adult behavioral response to amphetamine.
abstract: This study investigated whether exposure to cocaine during critical periods of brain development alters the motor stimulating effects of amphetamine given in adulthood. Female rats received 50 mg/kg/day cocaine HCl SC or vehicle during either postnatal days 1-10 or 11-20. At 60-65 days of age, activity counts were collected over a 15-min baseline period. Subjects then received one of 3 doses (0, 0.1, 0.25 mg/kg) of d-amphetamine sulfate SC followed by a 90-min period of activity monitoring. Adult activity in 1-10-day cocaine-treated rats was different from vehicle-treated rats in response to 0.1 mg/kg amphetamine only. Adult activity in 11-20-day cocaine-treated rats was different from vehicle-treated rats in response to 0.25 mg/kg only. The observed differences represented an increase and decrease in activity, respectively. These alterations in amphetamine response may be related to the observed alterations in D-1 receptor concentrations as well as the altered rates of brain glucose metabolism we have observed in adult rats neonatally exposed to cocaine.
authors.affiliation: Department of Neurosurgery, State University of New York Health Science Center, Brooklyn 11203.
authors.forename: H E
authors.initials: HE
authors.lastname: Hughes
authors.forename: G F
authors.initials: GF
authors.lastname: Pringle
authors.forename: L A
authors.initials: LA
authors.lastname: Scribani
authors.forename: D L
authors.initials: DL
authors.lastname: Dow-Edwards
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
chemical_list: D003042:Cocaine; D003913:Dextroamphetamine