title: Cytosine arabinoside and cisplatin for advanced breast cancer. A phase II study of the Cancer and Leukemia Group B.
abstract: Forty-four women with advanced breast cancer participated in a prospective clinical trial to evaluate the efficacy and toxicity of a regimen consisting of cytosine arabinoside and cisplatin. All patients had previously received chemotherapy. Three patients (7%) responded to therapy with response durations of 153, 160, and 441 days. The median time to disease progression and median survival time in all 44 patients were 2.3 and 5 months, respectively. This regimen had significant toxicity, with most patients experiencing severe or life-threatening hematologic, renal, or infectious complications. This regimen cannot be recommended for previously treated patients with advanced breast cancer.
authors.affiliation: Columbia University College of Physicians and Surgeons, New York, NY 10032.
authors.forename: M W
authors.initials: MW
authors.lastname: Oster
authors.forename: R L
authors.initials: RL
authors.lastname: Schilsky
authors.forename: D
authors.initials: D
authors.lastname: Faraggi
authors.forename: A H
authors.initials: AH
authors.lastname: Korzun
authors.forename: M
authors.initials: M
authors.lastname: Perry
authors.forename: A
authors.initials: A
authors.lastname: Moore
authors.forename: J
authors.initials: J
authors.lastname: Kalra
authors.forename: W C
authors.initials: WC
authors.lastname: Wood
authors.forename: I C
authors.initials: IC
authors.lastname: Henderson
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality; D002945:Cisplatin / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D015996:Survival Rate
chemical_list: D003561:Cytarabine; D002945:Cisplatin