The time course and magnitude of spontaneous recovery of parkinsonism produced by intracarotid administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to monkeys.
We studied rhesus monkeys with hemiparkinsonism or bilateral parkinsonism produced by unilateral or bilateral intracarotid administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Using a standardized clinical rating scale, 4 hemiparkinsonian monkeys showed a 13 to 56% (mean, 36%) spontaneous improvement during an observation period of up to 25 weeks. Generally, recovery leveled off after 14 weeks. Four bilaterally parkinsonian monkeys showed a 5 to 42% (mean, 22%) improvement over a period of up to 30 weeks. Our findings emphasize that spontaneous recovery is a potentially confounding characteristic of this monkey model when used for assessing novel antiparkinsonian therapies.
Kurlan
R
R
Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642.
Kim
M H
MH
Gash
D M
DM
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage; D000818:Animals; D002339:Carotid Arteries; D007269:Injections, Intra-Arterial; D020267:MPTP Poisoning; D008253:Macaca mulatta / Q000502:physiology; D010302:Parkinson Disease, Secondary / Q000209:etiology / Q000503:physiopathology*
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine