title: Effect of hirudin on the chemotactic properties of alpha-thrombin.
abstract: A study by an agarose technique of the chemotactic power of human alpha-thrombin on polymorphonuclear leukocytes reveals that this enzyme has a chemotactic activity. Hirudin, which inhibits the coagulant properties of thrombin, suppresses these chemotactic properties. This effect could be explained by the binding of hirudin to the structural domain of alpha-thrombin involved in its chemotactic activity.
authors.affiliation: Centre Régional de Transfusion Sanguine et d'Hématologie, Nancy, France.
authors.forename: A
authors.initials: A
authors.lastname: Morin
authors.forename: M
authors.initials: M
authors.lastname: Marchand-Arvier
authors.forename: C
authors.initials: C
authors.lastname: Doutremepuich
authors.forename: C
authors.initials: C
authors.lastname: Vigneron
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D002630:Chemotactic Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006629:Hirudins / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D011485:Protein Binding; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000187:drug effects / Q000378:metabolism / Q000494:pharmacology
chemical_list: D002630:Chemotactic Factors; D006629:Hirudins; D009240:N-Formylmethionine Leucyl-Phenylalanine; D013917:Thrombin