New approaches to drug design and delivery based on drug-membrane interactions.
In this review, the complex physical and chemical interactions of drugs with model and biological membranes under normal and pathological conditions are examined at the molecular level. The results of our own published and unpublished structural studies are discussed and correlated with kinetic binding studies to assess the potential role of nonspecific drug interaction with the membrane bilayer in the overall receptor binding mechanism for membrane-bound receptors in heart and brain.
Herbette
L G
LG
Department of Radiology, University of Connecticut Health Center, Farmington 06032.
Rhodes
D G
DG
Mason
R P
RP
D000465:Algorithms; D002121:Calcium Channel Blockers; D004333:Drug Administration Routes; D015195:Drug Design; D008564:Membrane Potentials / Q000187:drug effects; D011955:Receptors, Drug
D002121:Calcium Channel Blockers; D011955:Receptors, Drug