title: Serum lipid and apolipoprotein concentrations in healthy men on diets enriched in either canola oil or safflower oil.
abstract: This randomized, blind study measured changes in serum lipid and apolipoprotein concentrations in 16 men consuming 39 +/- 1% of energy (en%) as fat either from safflower- or canola-oil-based diets for 8 wk. Initially, the men were stabilized for 3 wk on a typical American (baseline) diet. Compared with baseline, the vegetable-oil-based diets reduced serum total cholesterol 9-15% (P less than 0.002), low-density-lipoprotein (LDL)-cholesterol 12-20% (P less than 0.002), and apolipoprotein B-100 21-24% (P less than 0.001). There were no significant changes from baseline to the end of the study in serum triglycerides, total high-density-lipoprotein (HDL) cholesterol, HDL3 cholesterol, HDL2 cholesterol, or apolipoprotein A-I. These data suggest that even if total fat intake remains at 39-40 en%, many men show lowered LDL cholesterol if saturated fatty acid intake is minimized and that diets high in polyunsaturated fatty acids do not necessarily lower HDL-cholesterol concentrations.
authors.affiliation: Division of Medical Dietetics, Ohio State University, Columbus 43210.
authors.forename: G M
authors.initials: GM
authors.lastname: Wardlaw
authors.forename: J T
authors.initials: JT
authors.lastname: Snook
authors.forename: M C
authors.initials: MC
authors.lastname: Lin
authors.forename: M A
authors.initials: MA
authors.lastname: Puangco
authors.forename: J S
authors.initials: JS
authors.lastname: Kwon
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100; D001053:Apolipoproteins / Q000097:blood*; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D000074262:Rapeseed Oil; D012450:Safflower Oil / Q000008:administration & dosage*; D016037:Single-Blind Method; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100; D001053:Apolipoproteins; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D008075:Lipoproteins, HDL; D000074262:Rapeseed Oil; D014280:Triglycerides; D012450:Safflower Oil; D002784:Cholesterol