title: Diagnosis of carotid artery stenosis: comparison of 2DFT time-of-flight MR angiography with contrast angiography in 50 patients.
abstract: Fifty patients underwent 2DFT time-of-flight MR angiography and intraarterial contrast angiography for evaluation of possible carotid atherosclerotic disease. The MR angiography technique employed contiguous axial flow-sensitive (short TR/TE) slices that were reformatted and postprocessed by using a maximum-intensity projection algorithm to provide 16 angiographic views of the carotid arteries. Both studies were independently reviewed by two observers in a blinded manner. Carotid arteries were categorized as normal, mildly stenotic, moderately stenotic, severely stenotic, or occluded. For the 94 carotid arteries available for review, one observer reported a 70% agreement between the two techniques and the second observer reported a 56% agreement (p = .0001). The best correlation was in the severely stenotic category and the worst was in the occluded category. Agreement between observers was 67% for MR angiography and 72% for contrast angiography, which was similar to that between the two techniques. Although not all carotid atherosclerotic disease was visualized equally well, 2DFT time-of-flight MR angiography had a good overall correlation with the "gold standard" of intraarterial contrast angiography, supporting its use as a screening technique. While further improvements are needed, use of MR angiography as the primary diagnostic tool for many patients with suspected carotid stenosis should continue to increase.
authors.affiliation: Department of Radiology, New York University Medical Center, NY 10016.
authors.forename: A W
authors.initials: AW
authors.lastname: Litt
authors.forename: E M
authors.initials: EM
authors.lastname: Eidelman
authors.forename: R S
authors.initials: RS
authors.lastname: Pinto
authors.forename: T S
authors.initials: TS
authors.lastname: Riles
authors.forename: S J
authors.initials: SJ
authors.lastname: McLachlan
authors.forename: S
authors.initials: S
authors.lastname: Schwartzenberg
authors.forename: J C
authors.initials: JC
authors.lastname: Weinreb
authors.forename: I I
authors.initials: II
authors.lastname: Kricheff
mesh_terms: D000368:Aged; D000465:Algorithms; D002340:Carotid Artery Diseases / Q000175:diagnosis*; D002533:Cerebral Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D002537:Intracranial Arteriosclerosis / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male