[Pharmacokinetics and local availability of mitomycin. The influence of vasoconstriction and chemoembolization].
The influence of the vasopressin-pro-drug glycylpressine (GP) and of a chemoembolisation with Spherex starch-particles (SP) on the availability of mitomycin (CAS 50-07-7, mitomycin C, MMC) was investigated in 30 patients with liver metastases, MMC administration was performed after blocking of the common hepatic artery by different concentrations of SP and after different time-intervals of GP. The comparison of plasma-levels after bolus injection without GP and after administration of MMC after 2, 5 and 15 min of vasoconstriction and after chemoembolisation with 450 mg or 900 mg SP, respectively, showed a remarkable reduction in the systemic circulation of MMC in the blood vessel system at about 40% (GP) and 45% (SP). A statistically significant influence on the pharmacokinetics of MMC with regard to CO, Vd, T 1/2zp, AUC and Cl(tot) was found, but not in t1/2el, t1/2biol and Vl. Both methods cause a distinctly accelerated diffusion of MMC into the tissue of the tumor region by change of the hemodynamics, leading to lowered side-effects. Thus the clinical picture was improved by MMC.
Czejka
M
M
Institut für Pharmazeutische Chemie, Universität Wien Osterreich.
Jäger
W
W
Schüller
J
J
Schernthaner
G
G
D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D004621:Embolization, Therapeutic; D006207:Half-Life; D006499:Hepatic Artery / Q000502:physiology; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary; D008236:Lypressin / Q000031:analogs & derivatives / Q000494:pharmacology; D016685:Mitomycin; D008937:Mitomycins / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013213:Starch; D000077585:Terlipressin; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D008937:Mitomycins; D014662:Vasoconstrictor Agents; D008236:Lypressin; D016685:Mitomycin; D000077585:Terlipressin; D013213:Starch
Pharmakokinetik und lokale Verfügbarkeit von Mitomycin. Einfluss von Vasokonstriktion und Chemoembolisation.