Oxygen dependence of lipid peroxidation in mice.
Peroxidation of lipids in serum and tissues of mice placed in low or high levels of oxygen was examined. After exposure to 100% oxygen for 3 h, no significant differences were observed between control and exposed mice. However, exposure to 100% oxygen for 6 h resulted in a decrease in oxygen consumption, an increase in lipid peroxides in tissues and serum, and the formation of hydroxyl radicals in tissues and serum. At low concentrations of oxygen (14% or 16%), a decrease in oxygen consumption, peroxidation of lipids and formation of hydroxyl radicals also were observed. Damage to mice was great with the lower oxygen concentrations of oxygen. There was a close correlation between the consumption of oxygen lipid peroxidation, formation of hydroxyl radicals.
Yoshimura
Y
Y
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Uchiyama
K
K
Ohsawa
K
K
Imaeda
K
K
Ohtani
Y
Y
Tamura
K
K
D000818:Animals; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000502:physiology*; D008054:Lipid Peroxides / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D010100:Oxygen / Q000502:physiology*; D010101:Oxygen Consumption / Q000502:physiology; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism
D005609:Free Radicals; D008054:Lipid Peroxides; D013482:Superoxide Dismutase; D010100:Oxygen