title: Synthesis and antifungal activity of some new benzimidazole derivatives.
abstract: Synthesis and antifungal evaluation of 5-ethoxycarbonyl-2-(substituted-benzyl or phenoxymethyl)benzimidazoles are reported. Structures of the compounds were elucidated with IR-, 1H-NMR-, 13C-NMR-, mass-spectra and elemental analysis. Preliminary results show that none of the synthesized benzimidazole derivatives has antifungal activity at the concentration of 100 micrograms/ml against Candida parapsilosis, Candida stellatoidea, and Candida pseudotropicalis.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Göker
authors.forename: R
authors.initials: R
authors.lastname: Ertan
authors.forename: H
authors.initials: H
authors.lastname: Akgün
authors.forename: N
authors.initials: N
authors.lastname: Yulug
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D001562:Benzimidazoles