The gene for the novel vasoactive peptide endothelin 3 (EDN3) is localized to human chromosome 20q13.2-qter.
Endothelin 3 is a novel vasoactive peptide of unique structure and belongs to the endothelin gene family. Though it mainly functions as a vasoconstrictor/pressor, it plays a major role in a wide variety of other biological functions, possibly as a novel neuropeptide. Studies with human-mouse somatic cell hybrids have suggested that the gene EDN3 is localized on human chromosome 20. We confirmed this localization and regionally mapped the gene to the region 20q13.2-q13.3.
Rao
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Institut für Humangenetik, Universität Göttingen, Federal Republic of Germany.
Löffler
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C
Hansmann
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I
D000818:Animals; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20; D016232:Endothelins / Q000235:genetics*; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D005810:Multigene Family
D016232:Endothelins