[Structure of pentaene antibiotic lavendofuseomycin].
By its UV spectrum lavendofuseomycin, a macrolide pentaene antibiotic, was referred to the subgroup of adeopentaenes with the spectral symmetrical patterns. The antibiotic contains a carbonyl, the end and 4 isolated double bonds and hemiketal ring. The molecule is lacking sugar. After the hydroantibiotic oxidation 2-methylhexadecane dicarboxylic and 4'-methyloctanoic acids were isolated. The antibiotic carbon skeleton was asserted on the basis of the mass spectral analysis of the products of the antibiotic complete reduction and the products of the antibiotic retroaldol cleavage. Determination of the position of the isolated double bonds, localization of chromophore, oxygen functions and the position of the amino group in the molecule resulted from investigation of the antibiotic azonolysis products.
Shenin
Iu D
IuD
Mitrofanova
V G
VG
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry* / Q000145:classification; D002210:Caprylates / Q000737:chemistry / Q000302:isolation & purification; D003998:Dicarboxylic Acids / Q000737:chemistry / Q000302:isolation & purification; D066298:In Vitro Techniques; D018942:Macrolides; D013058:Mass Spectrometry / Q000379:methods; D008970:Molecular Weight; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D002210:Caprylates; D003998:Dicarboxylic Acids; D018942:Macrolides; C070705:lavendofuseomycin; C031492:octanoic acid
Struktura pentaenovogo antibiotika lavendofuzeomitsina.