[The mechanisms of the disordered regulation of hematopoiesis in the late periods after the administration of cytostatic preparations].
It was demonstrated on an experimental model of cytostatic disease induced by a course of injections (1/10 LD50 for 10 days) of antineoplastic agents with various mechanism of action (doxorubicin, vinblastine, cyclophosphamide) that persistent (for 6 months) disorganization of the morphological composition of the thymus and other lymphoid organs is attended by inhibition of the functional activity of the T-cells of the immunity system. It is suggested that the weakened control (on the part of the thymus) due to the effect of the cytostatics may lead to disorders of the processes of proliferation and differentiation of the hematopoietic cells and impairment of the bone marrow morphological composition in late-term periods after cytostatic treatment.
V V
VV
Novitskiĭ
O B
OB
Zapuskalova
I V
IV
Bogdashin
E D
ED
Gol'dberg
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D006410:Hematopoiesis / Q000187:drug effects* / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D007376:Interleukin-2 / Q000032:analysis; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors
D000970:Antineoplastic Agents; D007376:Interleukin-2
Mekhanizmy narusheniia reguliatsii krovetvorenii v otdalennye sroki posle vvedeniia tsitostaticheskikh preparatov.