Increased lipoprotein X causes hyperlipidemia during intravenous administration of 10% fat emulsion in man.
To clarify the mechanisms of hyperlipidemia during intravenous Intralipid 10%, lipoprotein profiles including lipoprotein X were studied in 13 patients receiving 2.0 g of fat per kilogram per day by Intralipid 10% over a period of 8 weeks. All patients were fed exclusively by total parenteral nutrition providing 1.1 g of amino acid and 30 kcal/kg per day. Intravenous administration of Intralipid 10% caused a marked increase of low-density lipoprotein (LDL), phospholipid, and cholesterol, especially free cholesterol, whereas triglyceride, very-low-density lipoprotein, and high-density lipoprotein remained within the normal range. Lipid composition of LDL approximated that of lipoprotein X progressively with the intravenous Intralipid 10%. Quantification of lipoprotein X revealed that its increase was proportionate with that of LDL and total lipid. From these findings, hyperlipidemia during intravenous Intralipid 10% is induced almost exclusively by the increased lipoprotein X.
Tashiro
T
T
First Department of Surgery, Chiba University School of Medicine, Japan.
Mashima
Y
Y
Yamamori
H
H
Horibe
K
K
Nishizawa
M
M
Sanada
M
M
Okui
K
K
D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology*; D008055:Lipids / Q000097:blood; D008073:Lipoprotein-X / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total / Q000009:adverse effects; D010743:Phospholipids / Q000097:blood
D001053:Apolipoproteins; D005217:Fat Emulsions, Intravenous; D008055:Lipids; D008073:Lipoprotein-X; D010743:Phospholipids; D002784:Cholesterol