Contribution to the study of tetracycline bone side-effects. Absence of calcium deposition impairment in the trabecular bone of a patient treated during 3.5 years with doxycycline.
Tetracyclines are easily incorporated into bone; whether bone formation is impaired during this process is still a matter of debate. We therefore studied, by histomorphometry, fluorescence microscopy, and microradiography, a sample of trabecular bone from a patient with a total hip arthroplasty, treated without interruption for 3.5 years with doxycycline because of a pertrochanteric abscess. Absence of osteomalacia and a low-mineralization score of the edges of the trabeculae similar to that observed in a control group of 12 subjects suggest no interference by doxycycline with calcium deposition in bone.
Department of Rheumatology, Hôpital communal, La Chaux-de-Fonds, Switzerland.
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D
Van Linthoudt
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R
François
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H
Ott
D001170:Arthritis, Infectious / Q000188:drug therapy* / Q000473:pathology; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000378:metabolism*; D004318:Doxycycline / Q000008:administration & dosage / Q000009:adverse effects*; D006622:Hip Prosthesis; D006801:Humans; D007085:Ilium / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008852:Microradiography; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000601:surgery*; D011183:Postoperative Complications / Q000188:drug therapy* / Q000473:pathology; D011475:Prosthesis Failure; D012086:Reoperation; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000473:pathology
D004318:Doxycycline; D002118:Calcium