Medullipin system. Generation of medullipin II by isolated kidney-liver perfusion.
Perfusion of isolated normal rat kidneys with blood at elevated blood pressure (180-200 mm Hg) followed by perfusion of the renal perfusate through an isolated normal rat liver under venous pressure yielded in the plasma of the hepatic effluent a vasodepressor lipid having the chromatographic and biological characteristics of medullipin II. These findings support the view that medullipin II is the final product of the renohepatic axis of blood pressure control.
Department of Pathology, University of Tennessee, Memphis.
E E
EE
Muirhead
B
B
Brooks
L W
LW
Byers
P
P
Brown
J A
JA
Pitcock
D000818:Animals; D000959:Antihypertensive Agents / Q000378:metabolism*; D001794:Blood Pressure; D066298:In Vitro Techniques; D007679:Kidney Medulla / Q000378:metabolism*; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D000959:Antihypertensive Agents; D008055:Lipids; C070438:medullipin II