Effect of calcium channel blocker (diltiazem) on platelet aggregation.
Platelet aggregation with collagen, ADP and sodium arachidonate was significantly inhibited by 0.48 and 0.24 mg/ml of diltiazem but no significant effect occurred with 0.024 mg/ml of diltiazem. It is suggested that the antiplatelet property of diltiazem may be utilized in clinical setting and diltiazem may be tried synergistically with other antiplatelet drugs.
Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi.
S R
SR
Salam
R
R
Saxena
A K
AK
Saraya
D004110:Diltiazem / Q000494:pharmacology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology
D010975:Platelet Aggregation Inhibitors; D004110:Diltiazem