[Influence of duration of complete global brain ischemia on neurologic outcome in dogs].
The author studied the influence of duration of complete global brain ischemia (CGBI) on neurologic outcome (NO) in dogs. The CGBI of various durations, from 10 to 20 minutes, were induced by clamping of the ascending aorta combined with bypass formation between the aorta and the right atrium. The dogs were divided into four groups according to the duration of CGBI: dogs in group A, B, C or D suffered 10, 15, 18 or 20 minutes of CGBI respectively. In four groups, NOs were evaluated for 7 days after the ischemic insult. In group A, no significant damages were observed and all survived for 7 days. In group B, marked differences in the degree of neurologic deficits were observed, and nearly a half were almost normal and the remainder were severely damaged. In groups C and D, all were so severely damaged as to become vegetative and any difference in the degree of neurologic deficits was not observed among the groups. The author concludes that dogs which have suffered CGBI for 15 minutes or less are not suitable for use in order to evaluate the efficacy of treatments for ischemic brain damage with NOs, and that dogs which suffered CGBI for 18 minutes or more are appropriate for this purpose.
Department of Anesthesiology and Resuscitology, Okayama University Medical School.
M
M
Kondo
D000818:Animals; D001925:Brain Damage, Chronic / Q000209:etiology*; D002545:Brain Ischemia / Q000150:complications*; D004285:Dogs; D013997:Time Factors