Plurihormonal adenomas. Analysis of 62 cases.
This paper deals with the cytological features of pituitary plurihormonal adenomas based on 62 cases examined by histology, immunohistochemistry, ultrastructural study and post-embedding immunogold electron microscopy, including double labeling. In GH-cell containing adenomas, there were 9 adenomas consisting of exclusively GH and PRL cells. The other 39 adenomas contained other hormones as well as GH and PRL. Other nine combinations of pituitary hormones or alpha-subunit were observed. Special emphasis was laid on the fact that a greater part of GH-producing adenomas (74% by immunostain) were PRL-producing, although the ratio of GH-cells to PRL-cells widely varied from case to case. Concerning the double labeling study on mixed GH-PRL secreting adenomas, we recognized the existence of secretory granules containing GH only, those containing PRL only, those containing both GH and PRL and those containing neither.
Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
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Kameya
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Furuhata
D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D006046:Gold; D013006:Growth Hormone / Q000378:metabolism; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007158:Immunologic Techniques; D008854:Microscopy, Electron; D011388:Prolactin / Q000378:metabolism
D006728:Hormones; D006046:Gold; D011388:Prolactin; D013006:Growth Hormone