Radioiodine treatment of Basedow's disease: interference and influence factors, risk estimation.
I-131 treatment of Basedow's disease is effective and safe. Relatively high energy doses to the thyroid in the range of 150-200 Gray are needed in endemic goiter areas, where immunogenic hyperthyroidism may coincide with functional autonomy. Induction of euthyroidism by low doses of antithyroid drugs (methimazole, carbimazole) before I-131 treatment prevents complications and has no significant influence on outcome of I-131 therapy. As compared to alternative therapeutic modalities, the risks of I-131 are low.
Clinic for Nuclear Medicine, University of Essen.
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Reiners
D004307:Dose-Response Relationship, Radiation; D006111:Graves Disease / Q000532:radiotherapy*; D006801:Humans; D007455:Iodine / Q000037:antagonists & inhibitors; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012307:Risk Factors
D007457:Iodine Radioisotopes; D007455:Iodine