Aspergillus osteomyelitis of the spine.
Aspergillosis involving either the vertebral body or the intervertebral disc is a rare cause of osteomyelitis of the spine. The following is a report of five cases of Aspergillus fumigatus infection of the spine treated successfully with amphotericin B and 5-flucytosine. In three patients, the diagnosis was established at closed-needle biopsy; two patients with paraplegia had an anterior decompression and fusion. The follow-up period ranged from 19 to 48 months.
Govender
S
S
Department of Orthopaedic Surgery, University of Natal, Durban, South Africa.
Rajoo
R
R
Goga
I E
IE
Charles
R W
RW
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*; D011859:Radiography; D013122:Spinal Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*
D000666:Amphotericin B; D005437:Flucytosine