Cytogenetics of infantile leukemias and its correlations with bio-clinical features. The "G. Gaslini" Children's Hospital experience over a 9-year period.
METHODS
Infantile leukemia is a rare disorder, and few cytogenetic studies have been performed on this condition.


CONCLUSIONS
The authors present the cytogenetic analyses performed on 14 cases of infantile leukemia. The most frequent chromosomal changes are rearrangements involving 11q (4 cases) and gains of one or more chromosomes 21. Patients with chromosomal rearrangements show a worse prognosis than those with only hyperdiploidy or a normal karyotype, although the difference was not statistically significant due to the small size and short median follow-up.
Haupt
R
R
Divisione di Ematologia/Oncologia Pediatrica, Ospedale Pediatrico G. Gaslini Genova, Italy.
Comelli
A
A
Garré
M L
ML
Defferrari
R
R
Fugazza
G
G
Basso
G
G
Rosanda
C
C
Sessarego
M
M
Sansone
R
R
D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11 / Q000648:ultrastructure; D002891:Chromosomes, Human, Pair 21; D005260:Female; D005500:Follow-Up Studies; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D007558:Italy; D007938:Leukemia / Q000235:genetics* / Q000401:mortality; D008297:Male; D011003:Ploidies; D011379:Prognosis; D015996:Survival Rate