Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man.
An experimental evaluation of citrulline malate (Stimol, CAS 54940-97-5), an anti-fatigue compound, was undertaken in man and in the animal in order to study the pharmacological activity of the substance at hepatic and renal level. In man, the protocol involved a double-blind randomized, placebo-controlled cross-over technique. The study in the animal was blind and placebo-controlled with two randomized parallel groups. Results showed that citrulline malate stimulates hepatic ureogenesis and favorizes the renal reabsorption of bicarbonates. These metabolic actions had a protective effect against acidosis and ammonia poisoning and explain the anti-fatigue properties of citrulline malate in man.
Department of Medical Biophysics, Institut de Biologie, Montpellier, France.
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A
Callis
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B
Magnan de Bornier
J J
JJ
Serrano
H
H
Bellet
R
R
Saumade
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000328:Adult; D000596:Amino Acids / Q000097:blood*; D000641:Ammonia / Q000097:blood*; D000818:Animals; D002956:Citrulline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008293:Malates / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D008293:Malates; D002956:Citrulline; D000641:Ammonia; C071162:citrulline malate