[Closure of postoperative anastomotic fistulas with a somatostatin analogue].
Postoperative gastrointestinal fistula formation is not rare, and is accompanied by considerable morbidity and mortality. Somatostatin, a potential, universal endocrine and exocrine inhibitor, is a peptide synthesized in the nervous system and the gastrointestinal tract. We describe 2 men, 58 and 53 years old, respectively, with postoperative fistulas, the first after pancreatic-jejunal and the second after jejunal anastomosis. 7 and 3 days, respectively, after starting a synthetic somatostatin analogue (SMS 201-995), discharge from the fistulas decreased and they closed completely.
Gastroenterology Unit, Rebecca Sieff Government Hospital, Safed.
Y
Y
Niv
A
A
Hadari
V
V
Asaf
M
M
Oren
D000714:Anastomosis, Surgical; D006801:Humans; D007412:Intestinal Fistula / Q000188:drug therapy* / Q000209:etiology; D007579:Jejunal Diseases / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010185:Pancreatic Fistula / Q000188:drug therapy* / Q000209:etiology; D011183:Postoperative Complications / Q000188:drug therapy*
D015282:Octreotide