[The histological characteristics of human lung tumor transplants growing under the renal capsule of mice in an immunodepressed state].
In order to determine the prognostic value of a "subcapsular test" in assessment of individual sensitivity of lung tumors to antitumor action, research was conducted into the histological structure of 18 human lung tumors and 110 grafts of these tumors, which had grown within 6 days under the renal capsule in mice under the immunosuppressed condition, caused by whole-body irradiation. The presence of necrosis in an original tumor led to connective tissue growth in grafts. The stroma/parenchyma ratio in grafts was increased as compared to original tumors. Lymphoid infiltration in 6-day grafts was, as a rule, unmarked. In 2 of 18 cases histotypes of a primary tumor and its grafts differed, i. e. the "subcapsular test" could be used to detect latent polymorphism of lung tumors. Correct prognosis of an individual response of human lung tumors to antitumor action with the "subcapsular test" also necessitated histological verification of the results.
Frank
G A
GA
Sergeeva
N S
NS
Skotnikova
O I
OI
Pelevina
I I
II
D000818:Animals; D006801:Humans; D007108:Immune Tolerance / Q000528:radiation effects; D007680:Kidney Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D011379:Prognosis; D013370:Subrenal Capsule Assay; D013997:Time Factors
Gistologicheskie osobennosti transplantatov opukholeĭ legkogo cheloveka pri roste pod kapsuloĭ pochki mysheĭ v immunodepressivnom sostoianii.