The distribution of the HLA-DQ alpha alleles and genotypes in the Finnish population as determined by the use of DNA amplification and allele specific oligonucleotides.
Allele and genotype frequencies for the HLA-DQ alpha locus were determined for use in forensic analyses and paternity tests in Finland. The polymerase chain reaction (PCR) and the reverse dot blot format were employed to detect 6 different HLA-DQ alpha alleles. All 6 HLA-DQ alpha alleles were detected among the 112 unrelated individuals with allele frequencies ranging from 5.8% to 32.6%. The distribution of the observed genotypes is in Hardy-Weinberg equilibrium. Additionally, this Finnish population sample is statistically similar to 2 other Caucasian sample populations. The power of discrimination of this system in the Finnish population sample is 0.92, suggesting this method may prove suitable for identification purposes.
Sajantila
A
A
National Public Health Institute, Helsinki, Finland.
Ström
M
M
Budowle
B
B
Tienari
P J
PJ
Ehnholm
C
C
Peltonen
L
L
D000483:Alleles; D004247:DNA / Q000032:analysis*; D005387:Finland; D005554:Forensic Medicine / Q000379:methods*; D005784:Gene Amplification; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D009841:Oligonucleotides / Q000235:genetics; D044465:White People / Q000235:genetics*
D006683:HLA-DQ Antigens; D009841:Oligonucleotides; D004247:DNA