Changes in parafollicular cells of rats neonatally treated with estradiol.
The parafollicular cells of male and female rats neonatally (3rd day) treated with a single dose (1 mg) of estradiol dipropionate, and sacrificed in peripubertal (38th day) or adult (80th day) period of life, were investigated. These studies included examinations of silver-stained properties of parafollicular cells, morphometric analyses of both the cells and nuclear area and ultrastructural characteristics. Estradiol treatment led to a significant increase of the cellular and nuclear area (micron 2) in both females and males. Different from intact animals remarkable degranulation and hyperplasia of parafollicular cells were evident in estradiol-treated rats. It may be concluded that this sexual hormone applied in neonatal period has an effect on parafollicular cells expressed up to adult period of life.
Institute for Biological Research, Division of Cytology and Embryology, Beograd, Yugoslavia.
M
M
Sekulić
M
M
Lovren
D000818:Animals; D000831:Animals, Newborn; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects / Q000648:ultrastructure*
D004958:Estradiol