High-frequency ventilation: issues of strategy.
Although each high-frequency ventilator has functional characteristics that are design related, it now appears that when used with similar treatment strategies and within their functional limitations, similar clinical outcomes can be realized. Optimized treatment protocols must vary depending on the pulmonary disease to be treated, with strategies during treatment for pulmonary injury different from those used in pulmonary injury prevention. It is still unclear whether any one particular high-frequency ventilator will have specific disadvantages that cannot be overcome by device modification and that are inherent in a particular HFV methodology. Experimental and clinical data suggest that HFV will contribute significantly in reducing neonatal pulmonary morbidity and aid in the prevention of chronic pulmonary disease.
Gerstmann
D R
DR
Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, Texas.
deLemos
R A
RA
Clark
R H
RH
D002985:Clinical Protocols / Q000592:standards; D002986:Clinical Trials as Topic; D004867:Equipment Design; D006612:High-Frequency Ventilation / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000503:physiopathology / Q000628:therapy*; D008176:Lung Volume Measurements; D009359:Neonatology / Q000295:instrumentation*; D011659:Pulmonary Gas Exchange; D014481:United States; D014486:United States Food and Drug Administration