Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects.
Insulin responses to intravenous glucose infusion and glucose utilization during hyperinsulinaemic euglycaemic clamp were determined in a large homogeneous group of 65-year-old male subjects. Twenty-eight had untreated Type 2 (non-insulin-dependent) diabetes mellitus and the remaining 44 control subjects had a normal glucose tolerance. Diabetic patients with abdominal obesity displayed peripheral insulin resistance in combination with defective insulin secretion, whereas non-obese diabetic patients showed only a secretory defect. Thus, Type 2 diabetes in obese and non-obese elderly male subjects may take two forms where the cause of hyperglycaemia differs.
Department of Medicine, Huddinge Hospital, Karolinska Institute, Stockholm.
P
P
Arner
T
T
Pollare
H
H
Lithell
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003920:Diabetes Mellitus / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D012016:Reference Values
D001786:Blood Glucose; D007328:Insulin