[The DNA ploidy in squamous cell carcinomas of the mouth floor determined by flow cytometry].
The cellular DNA content of 90 primary squamous cell carcinomas of the floor of mouth was determined by flow cytometry. Aneuploid cell lines were detected in 86% of the cases. The proportion of diploid carcinomas decreased with size (T1: 63%, T2: 11%, T3: 7%) and histologic grade (G1: 17%, G2: 16%, G3: 9%). Only 15% of the diploid, but 61% of the aneuploid tumors showed evidence of lymph node involvement. A 96% sensitivity of the test and a negative predictive value of 85% emphasize the prognostic importance of DNA ploidy in the primary tumor to evaluate the risk of subclinical dissemination.
Universität Ulm, Abteilung für Mund-, Kiefer- und Gesichtschirurgie, Bundesrepublik Deutschland.
J
J
Hemmer
T
T
Thein
S
S
Haase
J
J
Kreidler
I
I
Heinle
D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry / Q000295:instrumentation / Q000379:methods; D006801:Humans; D008207:Lymphatic Metastasis; D009060:Mouth Floor; D009062:Mouth Neoplasms / Q000737:chemistry*; D011003:Ploidies
D004273:DNA, Neoplasm
DNA-Ploidie bei Plattenepithelkarzinomen des Mundbodens bestimmt mit Hilfe der Durchflusszytophotometrie.