Platelet imipramine binding and serotonin uptake in obsessive-compulsive patients.
Platelet imipramine binding was measured in 16 drug-free nondepressed patients (aged 20-61 years, mean +/- SD 35 +/- 8) suffering from obsessive-compulsive disorder (OCD) and in 16 sex-, race- and age-matched healthy controls. Imipramine binding capacity and affinity were not different in the 2 groups. Platelet serotonin (5-HT) uptake capacity, Vmax, was also measured in 15 of these patients and their matched controls. Vmax was significantly higher in the patients (309 +/- 149 pmol/10(9) cells/min) than in the controls (181 +/- 110). An increase in platelet 5-HT uptake supports the involvement of 5-HT in OCD and may suggest that a hyperactive serotonergic system is present in this disorder.
Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia.
B
B
Vitiello
H
H
Shimon
D
D
Behar
D
D
Stoff
W H
WH
Bridger
E
E
Friedman
D000328:Adult; D000367:Age Factors; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D012701:Serotonin / Q000097:blood / Q000378:metabolism* / Q000502:physiology; D012737:Sex Factors
D012701:Serotonin; D007099:Imipramine