[Disordered lymphoid regulation of hematopoiesis in iron-deficiency anemia].
Iron-deficiency anemia (IDA) in rats is attended by secondary cellular immunodeficiency. The authors studied the importance of lymphocyte dysfunction in the pathogenesis of hematological disorders in rats with IDA. Transplantation of lymphocytes from intact donors subjected to hypoxia to syngeneic recipients led to stimulation of erythropoiesis in them. The effect of "iron deficiency' cells was less manifest. It was established that the hematological disorders in IDA are lymphocyte-determined. This was also demonstrated in experiments on rats with IDA and changed functional condition of the lymphoid tissue.
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VV
Bazarnyĭ
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AP
Iastrebov
D000747:Anemia, Hypochromic / Q000097:blood / Q000276:immunology / Q000503:physiopathology*; D000818:Animals; D001803:Blood Transfusion; D004195:Disease Models, Animal; D004920:Erythropoiesis / Q000502:physiology; D006411:Hematopoiesis, Extramedullary / Q000502:physiology*; D007114:Immunization; D007165:Immunosuppression Therapy; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
Narushenie limfoidnoĭ reguliatsii krovetvoreniia pri zhelezodefitsitnoĭ anemii.