Safety of hypercapnic challenge: cardiovascular and neurologic considerations.
The hemodynamic, cerebrovascular, and neurologic effects of hypercapnia with 4% and 6% CO2 were retrospectively reviewed in 217 patients referred for regional CBF (rCBF) procedures. Inhalation of CO2 significantly increased rCBF, blood pressure, and pulse from baseline. The findings suggest a higher incidence of side effects with 6% CO2 concentration and an equivalent vasoreactivity to 4%. We recommend the use of 4% CO2 for hypercapnic stimulation, and present safety guidelines for its use.
Brain Imaging Division, New York State Psychiatric Institute, New York.
D R
DR
Gitelman
I
I
Prohovnik
T K
TK
Tatemichi
D000280:Administration, Inhalation; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000009:adverse effects / Q000494:pharmacology; D002319:Cardiovascular System / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006801:Humans; D009420:Nervous System / Q000503:physiopathology*; D012189:Retrospective Studies
D002245:Carbon Dioxide