Guanidination of a peptide side chain amino group on a solid support.
A novel guanidination method of converting a peptide side chain amino group to a guanidino group on a solid support is described. Four guanidinating reagents were evaluated using a model tetrapeptide attached to a polystyrene resin. Experimental data indicate that the two nitroguanidinating reagents, but not the two tosylguanidinating reagents, can be used effectively in solid phase peptide synthesis.
Tian
Z P
ZP
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis.
Roeske
R W
RW
D001559:Benzhydryl Compounds / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006146:Guanidines / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009587:Nitrogen Isotopes; D009952:Ornithine / Q000138:chemical synthesis; D010455:Peptides / Q000138:chemical synthesis*
D001559:Benzhydryl Compounds; D006146:Guanidines; D009587:Nitrogen Isotopes; D010455:Peptides; C070954:4-methylbenzhydrylamine; D009952:Ornithine