[Immunological study of endogenous uveitis. I. Dynamic study of autoimmunoreaction].
The autoimmunoreaction was determined with pig eye antigen and bovine retinal soluble antigen (S-Ag) in 77 patients with endogenous uveitis (EU) and 100 healthy individuals. The results showed that lymphocytes of 6 (35.3%) of 17 patients with EU reacted to bovine S-Ag, while those of all 10 healthy subjects were negative. The positivity and titers of serum autoantibodies in the patients with EU were significantly higher than in the healthy subjects and was also related to the activity of EU. These data suggested that the S-Ag sensitized lymphocytes played an important role in the pathogenesis of pan-uveitis, and the serum autoantibodies were significant in the aggravation of EU.
Zhang
M D
MD
Department of Ophthalmology, Teaching Hospital, Anhui Medical University, Hefei.
Huang
S R
SR
D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000276:immunology*; D019393:Arrestin; D001323:Autoantibodies / Q000097:blood*; D005136:Eye Proteins / Q000276:immunology*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D014605:Uveitis / Q000276:immunology*; D014606:Uveitis, Anterior / Q000276:immunology*
D000941:Antigens; D019393:Arrestin; D001323:Autoantibodies; D005136:Eye Proteins