Woodfordin D and oenothein A, trimeric hydrolyzable tannins of macro-ring structure with antitumor activity.
Two new antitumor trimeric hydrolyzable tannins, woodfordin D (5) and oenothein A (13), were isolated from the dried flowers of Woodfordia fruticosa, and their macrocyclic structures, which have a novel constituent unit (woodfordinoyl group) connecting the monomers, have been elucidated on the basis of spectral and chemical evidence. Oenothein A (13) was also isolated from the leaves of Oenothera biennis.
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
T
T
Yoshida
T
T
Chou
M
M
Matsuda
T
T
Yasuhara
K
K
Yazaki
T
T
Hatano
A
A
Nitta
T
T
Okuda
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D006868:Hydrolysis; D047348:Hydrolyzable Tannins; D010946:Plants, Medicinal / Q000737:chemistry; D013634:Tannins / Q000737:chemistry / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D047348:Hydrolyzable Tannins; D013634:Tannins; C071080:woodfordin D; C071081:oenothein A