Electrophoretic analysis of enzyme-linked immunoglobulins and their clinical significance.
The appearance of circulating enzyme-linked immunoglobulin complexes (E-Ig) is common for most enzymes used in clinical biochemical tests. The presence of E-Ig may result in altered enzyme activity in serum and interfere with the measurement of isoenzymes, and is thus of diagnostic importance. E-Ig can be identified by confirming that the binding protein is an immunoglobulin by its reaction with specific anti-human immunoglobulin antibodies. Currently, the presence of E-Ig in an individual is regarded as a benign phenomenon, not indicative of any particular disease process. However, it is becoming clear that E-IgG are closely associated with autoimmune states.
Department of Clinical Laboratories, Hyogo College of Medicine, Nishinomiya, Japan.
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Tozawa
D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000201:enzymology / Q000276:immunology; D004586:Electrophoresis / Q000379:methods; D004798:Enzymes / Q000097:blood* / Q000276:immunology; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods; D007527:Isoenzymes / Q000097:blood
D001323:Autoantibodies; D004798:Enzymes; D007527:Isoenzymes