Excitatory effects of cholecystokinin octapeptide on rat nodose ganglion cells in vitro.
Cholecystokinin octapeptide (CCK-8) applied by pressure evoked in the majority of rat nodose ganglion cells a rapid depolarization associated with a fall of membrane resistance and in a few cells a slow depolarization accompanied by an increase of membrane resistance. The fast depolarizations were increased and decreased by membrane hyperpolarization and depolarization; the extrapolated reversal potential was about -10 mV. The response was depressed in a Na-free solution and by d-tubocurarine (10-100 microM) but not in a Cl-deficient solution. It is concluded that CCK-8 depolarized the nodose ganglion cells by increasing cation conductances and in a few cells it also produced a slow excitation, the mechanism of which remains to be established.
Department of Anatomy, Medical College of Ohio, Toledo 43699.
N J
NJ
Dun
S Y
SY
Wu
C W
CW
Lin
D000818:Animals; D002712:Chlorides / Q000494:pharmacology; D004553:Electric Conductivity / Q000187:drug effects; D004594:Electrophysiology / Q000379:methods; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009620:Nodose Ganglion / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000494:pharmacology*; D014403:Tubocurarine / Q000494:pharmacology
D002712:Chlorides; D012844:Sincalide; D014403:Tubocurarine