Effect of Pseudomonas aeruginosa-derived pyocyanin and 1-hydroxyphenazine on pulmonary mucociliary clearance monitored scintigraphically in the baboon model.
The effect of products of the bacterium Pseudomonas aeruginosa on mucociliary lung clearance has been monitored in vivo in the baboon model by scintigraphy. Clearance was found to be inhibited by both 1-hydroxyphenazine and pyocyanin, and a dose-effect was illustrated by the former. This confirms previous in vitro results as well as results from work on guinea-pigs, and holds good prospects for the use of the baboon model under anesthesia in such investigations.
AEC Institute for Life Sciences, University of Pretoria, South Africa.
I
I
Dormehl
G
G
Ras
G
G
Taylor
N
N
Hugo
D000336:Aerosols; D000818:Animals; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008863:Microspheres; D009079:Mucociliary Clearance / Q000187:drug effects*; D010215:Papio; D010619:Phenazines / Q000378:metabolism / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D011710:Pyocyanine / Q000378:metabolism / Q000494:pharmacology*; D011877:Radionuclide Imaging; D012709:Serum Albumin / Q000493:pharmacokinetics; D013667:Technetium
D000336:Aerosols; D010619:Phenazines; D012709:Serum Albumin; C050093:1-hydroxyphenazine; D013667:Technetium; D011710:Pyocyanine