Prevalence of serum precipitating antibodies in horses to fungal and thermophilic actinomycete antigens: effects of environmental challenge.
Sera from 54 two- to three-year-old Thoroughbred horses from an English racing stable were examined for precipitins to antigen extracts prepared from 18 species of moulds (fungi and thermophilic actinomycetes) isolated from the same stable. Twenty-seven horses exhibited serum precipitins to one or more antigens; sixteen of the mould antigens elicited positive reactions in sera from one or more horses. Significantly more precipitins occurred in sera of those horses stabled in a barn than among those stabled in individual boxes. This indicated a possible association between type of housing, level of exposure to airborne moulds and presence of serum precipitins. None of the horses had overt respiratory disease. This study agrees with reports of the presence of serum precipitating antibodies to mould antigens in clinically healthy horses and confirms that serological tests, therefore, are of little value in the diagnosis of chronic obstructive pulmonary disease (COPD) or 'heaves'.
Department of Animal Husbandry, University of Bristol, School of Veterinary Science, Langford, Avon, UK.
T M
TM
Madelin
A F
AF
Clarke
T S
TS
Mair
D000192:Actinomycetales / Q000276:immunology; D000193:Actinomycetales Infections / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D000391:Air Microbiology; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D000908:Antibodies, Fungal / Q000097:blood*; D004391:Dust; D006734:Horse Diseases / Q000453:epidemiology* / Q000276:immunology; D006736:Horses; D006799:Housing, Animal; D005779:Immunodiffusion; D009181:Mycoses / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D015995:Prevalence
D000907:Antibodies, Bacterial; D000908:Antibodies, Fungal; D004391:Dust