[The gastric mucosa of the human fetus. II. Ontogenesis of the gastric glands in the strict sense].
The ontogenesis of the gastric glands of the fundus-corpus zone (oxyntic glands), in 37 human foetuses ranging from 9 to 16 weeks of gestational age, has been studied by light and electron microscopy. At 9 weeks of age the gastric mucosa already shows numerous and well developed gastric pits. Between 9 and 12 weeks of age, the proliferation of the epithelial cells at the bottom of the gastric pits gives rise to the glandular buds; the glandular lumen comes out later, at 13-16 weeks of age. The differentiation of the epithelial cells in the developing oxyntic glands does not occur simultaneously; on the basis of their morphological distinctive features it is possible to distinguish four principal types of epithelial cells: the endocrine cells are already present at 9 weeks of age; the parietal cells appear at 11-12 weeks; whereas the mucous neck cells and the zymogen cells can be recognized from the 12th week. During the studied gestational period no morphological sign of active exocrine secretion of oxyntic glands has been observed.
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Istituto di Anatomia umana normale, Università di Sassari.
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D002454:Cell Differentiation; D004847:Epithelial Cells; D005089:Exocytosis; D005753:Gastric Mucosa / Q000196:embryology* / Q000648:ultrastructure; D005865:Gestational Age; D006801:Humans; D008854:Microscopy, Electron; D010295:Parietal Cells, Gastric / Q000648:ultrastructure*
La mucosa gastrica nel feto umano. II. L'ontogenesi delle ghiandole gastriche propriamente dette.