[The mechanism of corneal ring formation caused by bacterial endotoxin].
Corneal ring can be produced experimentally by injection of endotoxin into the rabbit cornea. To clarify this phenomenon, the effects of inhibitors of arachidonic acid metabolite were studied on the formation of the corneal ring. Phospholipase A2 inhibitor (dexamethasone) and lipoxygenase inhibitor (TEI-3308) blocked the accumulation of polymorphonuclear leukocytes (PMNs) in the endotoxin-injected cornea, while cyclooxygenase inhibitor (indomethacin) enhanced PMN accumulation. This result suggests that products of the lipoxygenase reaction of arachidonic acid are related to the formation of the corneal ring induced by endotoxin. The existence of endotoxin in active form for a long period was also demonstrated immunohistochemically.
Miura
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Department of Bacteriology, School of Medicine, Iwate Medical University, Morioka, Japan.
D000038:Abscess / Q000139:chemically induced* / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D003316:Corneal Diseases / Q000139:chemically induced* / Q000378:metabolism; D015715:Corneal Edema / Q000139:chemically induced / Q000378:metabolism; D004731:Endotoxins / Q000493:pharmacokinetics / Q000494:pharmacology*; D004926:Escherichia coli; D006893:Hydroxyeicosatetraenoic Acids / Q000502:physiology; D007150:Immunohistochemistry; D007267:Injections; D008297:Male; D011817:Rabbits; D012475:Salmonella
D004731:Endotoxins; D006893:Hydroxyeicosatetraenoic Acids; D016718:Arachidonic Acid