Effect of cicletanine on overpacing-induced ST-segment elevation in conscious rabbits. A comparison with verapamil.
We compared the effects of cicletanine (10 mg/kg i.v.) and verapamil (0.1 mg/kg i.v.) on heart rate, ventricular effective refractory period, systolic and diastolic arterial blood pressure and overpacing-induced ST-segment elevation detected by right ventricular intracavital electrogram in conscious rabbits. Cicletanine significantly reduced overpacing-induced ST-segment elevation, which is an indicator of myocardial ischemia, and heart rate, but did not influence blood pressure and ventricular effective refractory period. Verapamil did not significantly influence ventricular effective refractory period, blood pressure or heart rate, but reduced the ST-segment elevation induced by frequency loading. These results suggest that acute treatment with cicletanine induces an anti-ischemic effect in the overpaced heart of conscious rabbits.
Department of Pharmacology, Albert Szent-Györgyi Medical School of Szeged, Hungary.
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Szilvássy
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Koltai
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L
Szekeres
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T
Tarrade
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Braquet
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003243:Consciousness; D003327:Coronary Disease / Q000188:drug therapy; D004232:Diuretics / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011725:Pyridines; D011817:Rabbits; D016276:Ventricular Function / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology*
D004232:Diuretics; D011725:Pyridines; C038068:cicletanine; D014700:Verapamil