Experimental study of the potential for contact sensitization and cross-reaction of imidazole antifungals.
We examined the potential for contact sensitization of miconazole nitrate and croconazole hydrochloride and the cross-reaction between them in guinea pigs by the maximization test of Magnusson and Kligman. Contact sensitivity was induced by croconazole hydrochloride in 5 out of 7 animals which, after being injected with 5% croconazole hydrochloride, underwent a closed patch with 25% croconazole hydrochloride. Contact sensitivity was not induced by miconazole nitrate. The 5 animals sensitized to croconazole hydrochloride were tested with 8 other imidazole antifungals and positive reactions were observed to oxiconazole nitrate in 2 of the 5 animals. This response may be a cross-reaction.
Nishioka
K
K
Department of Dermatology, Yamaguchi University School of Medicine, Japan.
Kurata
K
K
Asagami
C
C
D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects* / Q000276:immunology; D003429:Cross Reactions; D003877:Dermatitis, Contact / Q000209:etiology* / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D007093:Imidazoles / Q000009:adverse effects; D007271:Injections, Intradermal; D008825:Miconazole / Q000009:adverse effects; D010328:Patch Tests
D000935:Antifungal Agents; D007093:Imidazoles; C038008:croconazole; C029899:imidazole; D008825:Miconazole