Antagonism of airway reactivity induced by ovalbumin antigen in guinea pigs by 5-amino-4-imidazolecarboxamide riboside.
The effect of 5-amino-4-imidazolecarboxamide riboside (AICA riboside), a modulator of purine metabolism, was studied on antigen-induced bronchospasm in ovalbumin (OA)-sensitized guinea pigs. In separate experiments, sodium cromoglycate (SCG) and terbutaline were used to compare their effectiveness with that of AICA riboside (wt/vol). AICA riboside and SCG were administered as an aerosol daily for a minimum of 2 weeks before OA aerosol challenge. Terbutaline, as an aerosol, was administered once 5 minutes before OA challenge. Airway reactivity was determined through the use of a whole-body plethysmography by monitoring specific airway resistance (SRaw). OA aerosol challenge of 0.05%, 0.1%, and 0.25% (wt/vol), administered for a period of 1 minute, increased SRaw. Each of the three agents attenuated the effect of OA on SRaw, although terbutaline demonstrated more consistency and potency as compared to either AICA riboside or SCG. However, at moderate degrees of OA challenge, AICA riboside appeared to be as effective as either agent. Although the mechanism of action of AICA riboside remains uncertain, it may have therapeutic benefit in the treatment of asthma or allergic diseases.
Bergren
D R
DR
Creighton University School of Medicine, Department of Biomedical Sciences, Omaha, NE 68178.
Townley
R G
RG
Marquardt
D L
DL
Gruber
H E
HE
Bergren
V A
VA
D000620:Aminoimidazole Carboxamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001986:Bronchial Spasm / Q000503:physiopathology*; D016084:Bronchoconstriction / Q000187:drug effects; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000494:pharmacology; D006168:Guinea Pigs; D010047:Ovalbumin; D010993:Plethysmography, Whole Body; D012263:Ribonucleosides / Q000008:administration & dosage / Q000494:pharmacology*; D013726:Terbutaline / Q000008:administration & dosage / Q000494:pharmacology
D012263:Ribonucleosides; D000620:Aminoimidazole Carboxamide; C011651:acadesine; D010047:Ovalbumin; D013726:Terbutaline; D004205:Cromolyn Sodium