Modified posterior exenteration for ovarian cancer.
The operative description of a modified posterior exenteration along with operative findings, other operative procedures, postoperative course, and follow-up information are presented for 47 patients (37 primary cytoreduction, ten secondary cytoreduction). All had stage IIIC or IV epithelial ovarian cancer with pelvic disease encasing the reproductive organs, pelvic peritoneum, cul-de-sac, and sigmoid colon. In addition to modified posterior exenteration, all patients had multiple other procedures performed as part of the cytoreductive efforts. Forty-five (95.7%) had optimal (less than 2 cm) cytoreduction and 18 (38.3%) had complete cytoreductive surgery. Thirty-four patients were ultimately rendered continent of feces (25 primarily and nine after colostomy reversal). Nine patients (19.1%) had serious morbidity and one (2.1%) died postoperatively. The median follow-up for those undergoing primary cytoreduction was 13.3 months (6-84). Nineteen (51.4%) were alive at the time of writing, 16 (43.2%) were dead, and two (5.4%) were lost to follow-up. Modified posterior exenteration effectively removes all visible pelvic disease with acceptable mortality. Hence, even patients with the most advanced cases of ovarian cancer may attain optimal cytoreduction and become ideal candidates for adjunctive therapy, with improved survival or a chance for cure.
Center for Gynecologic Oncology, Encino, California.
S M
SM
Eisenkop
R H
RH
Nalick
N N
NN
Teng
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D012809:Colon, Sigmoid / Q000601:surgery; D003125:Colostomy / Q000379:methods; D003536:Cystadenocarcinoma / Q000556:secondary / Q000601:surgery; D004210:Dissection; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000601:surgery*; D010385:Pelvic Exenteration / Q000009:adverse effects / Q000379:methods*; D010537:Peritoneum / Q000601:surgery; D011183:Postoperative Complications; D012007:Rectum / Q000601:surgery; D012086:Reoperation; D012404:Round Ligament of Uterus / Q000601:surgery; D013997:Time Factors