On the expression of HMG I protein in quiescent and proliferating human T lymphocytes.
The results demonstrate that the HMG I protein is expressed in human quiescent T lymphocytes and hence is not dependent upon proliferation or neoplastic transformation. Furthermore it has been found that the HMG I/histone H1 ratio increase about two-fold after activation with phytohemagglutinin and was about the same as in a number of proliferating human leukemia lymphoma T-cell lines.
Department of Biochemistry, University of Oslo, Norway.
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Jyranoja
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Lund
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Lea
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Laland
D000911:Antibodies, Monoclonal; D015153:Blotting, Western; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D006609:High Mobility Group Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D006609:High Mobility Group Proteins; D006657:Histones