Dosimetry and pharmacokinetics of monoclonal antibody A6H with human renal cell carcinoma xenografts: single dose study.
Implantable miniature thermoluminescent dosimeters and conventional biodistribution analysis were used to determine the locally absorbed radiation dose delivered to three morphologically distinct human renal cell carcinoma xenografts (TK-39, TK-82 and TK-177C; N = 87) following a 50 microCi infusion of 131iodine-labeled monoclonal antibody A6H. Xenografts were clearly detected by radioimmuno-scintigraphy. Pronounced differences were noted among the three xenografts in MAb pharmacokinetics and in the locally absorbed irradiation doses which ranged from 2 to 5 cGy per injected microCi of 131iodine-labelled A6H.
Department of Microbiology, University of Minnesota Medical Center, Minneapolis 55455.
D F
DF
Palme
J M
JM
Berkopec
B W
BW
Wessels
M K
MK
Elson
P H
PH
Lange
R L
RL
Vessella
D000818:Animals; D000911:Antibodies, Monoclonal; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging*; D006801:Humans; D015592:Immunoradiometric Assay; D007457:Iodine Radioisotopes; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging*; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011786:Quality Control; D011877:Radionuclide Imaging; D013816:Thermodynamics; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes