Heredity and dysmorphic syndromes in congenital limb deficiencies.
Isolated limb deficiencies are usually sporadic occurrences. However, if they are associated with other abnormalities or a family history, the risk to future pregnancies may be as high as 50%. A thorough history, examination and investigation of the baby as well as the parents is essential before assessing this recurrence risk. The syndromes associated with limb deficiencies are presented.
Evans
D G
DG
Department of Medical Genetics, St. Mary's Hospital, Manchester, UK.
Thakker
Y
Y
Donnai
D
D
D000015:Abnormalities, Multiple / Q000209:etiology / Q000235:genetics*; D000818:Animals; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D017880:Limb Deformities, Congenital; D008297:Male