Dramatic recovery from neurological deficits in a patient with central pontine myelinolysis following severe hyponatremia.
A 28-year-old woman developed central pontine myelinolysis (CPM) following severe hyponatremia. Radiological examinations demonstrated a characteristic pontine lesion of CPM. Her neurological symptoms (drowsiness, emotional lability, dysarthria, dysphagia, and quadriparesis) were improved dramatically by treatment with thyrotropin-releasing hormone (TRH) and rehabilitation. However, results of repeat computed tomographic (CT) scans of the brain remained unchanged. This case therefore suggests that TRH may be beneficial for the treatment of CPM, and that CT findings appear to be a limited prognostic indicator for CPM.
Department of Internal Medicine, Yuri-Kumiai General Hospital, Honjo, Japan.
H
H
Wakui
S
S
Nishimura
Y
Y
Watahiki
Y
Y
Endo
Y
Y
Nakamoto
A B
AB
Miura
D000028:Abortion, Induced; D000328:Adult; D003244:Consciousness Disorders / Q000188:drug therapy / Q000209:etiology*; D003711:Demyelinating Diseases / Q000209:etiology*; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects*; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000628:therapy*; D007010:Hyponatremia / Q000150:complications* / Q000188:drug therapy; D007262:Infusions, Intravenous; D011149:Pons / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use*; D014869:Water Intoxication / Q000209:etiology*
D013973:Thyrotropin-Releasing Hormone