[Multiple cerebrovascular lesions as fatal late sequelae of syphilis].
A previously healthy man, aged 33 years, suddenly developed a hemiparesis and right facial paresis, as well as anisocoria and motor aphasia, preceded by recurrent attacks of dizziness. On admission he was somnolent. A flow murmur was heard over both carotid arteries; the blood pressure was 160/80 mm Hg. Cerebral computed tomography demonstrated multiple hypodense areas in the area supplied by several cerebral arteries, and marked cerebral oedema. Angiography of the aortic arch and the supra-aortic branches showed an occlusion of the left common carotid artery and a stenosis of the brachiocephalic trunk. The cerebral oedema, caused by ischaemia, did not respond to treatment. The patient died on the fourth hospital day from brainstem "strangulation". At autopsy syphilitic mesaortitis with characteristic lymphoplasmacellular endangiitis of the vasa vasorum of the aortic arch was demonstrated as the cause of the "aortic arch syndrome". Serology confirmed the diagnosis of an untreated tertiary syphilis. (VDRL titre 1:256; TPHA reactive; IgM-SPHA titre 1:64). Although a very rare cause, a late stage of syphilis should be considered in the differential diagnosis of cerebrovascular lesions in youngish patients.
Valentin
A
A
II. Medizinische Abteilung und Zentralröntgeninstitut der Krankenanstalt Rudolfstiftung, Wien.
Karnik
R
R
Anzböck
W
W
Slany
J
J
D000328:Adult; D001015:Aortic Arch Syndromes / Q000209:etiology; D002533:Cerebral Angiography; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009494:Neurosyphilis / Q000000981:diagnostic imaging / Q000473:pathology; D013589:Syphilis, Cardiovascular / Q000000981:diagnostic imaging / Q000473:pathology
Multiple zerebrovaskuläre Läsionen als letale leutische Spätfolgen.