Gamma interferon-activated human macrophages and Toxoplasma gondii, Chlamydia psittaci, and Leishmania donovani: antimicrobial role of limiting intracellular iron.
Iron-saturated transferrin did not reverse the intracellular killing or inhibition of Toxoplasma gondii, Chlamydia psittaci, or Leishmania donovani by gamma interferon-activated human macrophages. Deferoxamine, an iron chelator, also did not impair replication within unstimulated macrophages. Limiting the availability of intracellular iron is an unlikely mechanism in human macrophage activity against these three diverse pathogens.
Division of Infectious Diseases, Cornell University Medical College, New York, New York 10021.
H W
HW
Murray
A M
AM
Granger
R F
RF
Teitelbaum
D000818:Animals; D002691:Chlamydophila psittaci / Q000254:growth & development*; D003676:Deferoxamine / Q000494:pharmacology; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D007501:Iron / Q000502:physiology*; D007893:Leishmania donovani / Q000254:growth & development*; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000276:immunology; D014122:Toxoplasma / Q000254:growth & development*
D007371:Interferon-gamma; D007501:Iron; D003676:Deferoxamine