Nicotine-induced fos-like immunoreactivity in rat sympathetic ganglia and adrenal medulla.
The expression of c-fos proteins (Fos) in principal sympathetic neurons and adrenal chromaffin cells was studied immunocytochemically after a single s.c. injection of nicotine (2mg/kg). One and 2 h after injection most of the adrenal chromaffin cells showed nuclear Fos-like immunoreactivity (Fos-IR). In the superior cervical ganglion more than 80% of the neuronal nuclei were Fos-IR 2-5 h after nicotine administration, whereas only 50-60% of the neurons in the hypogastric ganglion were immunoreactive at these time points. The results suggest that nicotinic receptor mediates signal transduction, which induces c-fos expression both in sympathetic neurons and in adrenal chromaffin cells in vivo.
Department of Public Health, University of Tampere, Finland.
J
J
Koistinaho
D000313:Adrenal Medulla / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism; D009538:Nicotine / Q000494:pharmacology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D016760:Proto-Oncogene Proteins c-fos; D009538:Nicotine