Multivariate study of enterobacteria and Pseudomonas in saliva of patients with acute leukemia.
The effect of antibacterial treatment on the prevalence of gram-negative rods (enterobacteria and Pseudomonas) in the mouths of patients with leukemia was studied. Of the patients' salivary samples, 45% contained gram-negative rods compared with 12% in a control group of healthy persons. The antibacterial resistance patterns of gram-negative rods from healthy persons were different from those of the hospitalized patients. No relationship was found between the amount of antibacterial treatment and presence of gram-negative rods. The gram-negative rods recovered from individual patients were usually not resistant to the antibacterial agents given to the patients in question. Only a few patients harbored the same clone of a gram-negative rod for a lengthy period. The resistance patterns of these clones of gram-negative rods were similar to those of gram-negative rods that were transient in the mouth. It was concluded that resistance to antibacterial agents is not a factor of major importance for the capacity of the gram-negative rods to become established in the mouths of hospitalized patients with leukemia.
Department of Pedodontics, University of Umeå, Sweden.
Y B
YB
Wahlin
S
S
Granström
S
S
Persson
M
M
Sjöström
D000293:Adolescent; D000328:Adult; D000368:Aged; D000617:Aminoglycosides; D000667:Ampicillin / Q000494:pharmacology; D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000382:microbiology*; D011549:Pseudomonas / Q000187:drug effects / Q000302:isolation & purification*; D012463:Saliva / Q000382:microbiology*; D014295:Trimethoprim / Q000494:pharmacology; D014296:Trimethoprim Resistance
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000667:Ampicillin; D014295:Trimethoprim