[Functional effects of pentagastrin and diagnostic possibilities of the pentagastrin test].
The effect on gastric secretion of a single pentagastrin dose (6 micrograms/kg) against submaximal doses of histamine, euphylline and limontar was studied in 100 healthy subjects aged 20-30. It is shown that pentagastrin test corresponds to maximal histamine test allowing rough measurement of lining cells mass. Normal secretory values and mass of the lining cells have been established as well as normal secretory response of the stomach to submaximal histamine (0.008 mg/kg) and euphylline (7 mg/kg) tests. Diagnostic significance of the pentagastrin test in peptic ulcer and chronic gastritis with secretory insufficiency has been supported. There were some cases of secretory response to euphylline and limontar in pentagastrin-refractory forms of gastric secretion due to mobilization of functional cellular component of the gastric glands. Pentagastrin inhibited initially enhanced gastric evacuation though motor function of the stomach showed no response.
Tsimmerman
Ia S
IaS
Golovanova
E S
ES
D000328:Adult; D004381:Duodenal Ulcer / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008954:Models, Biological; D010295:Parietal Cells, Gastric / Q000187:drug effects / Q000378:metabolism; D010418:Pentagastrin / Q000494:pharmacology*; D010434:Pepsin A / Q000378:metabolism*; D013268:Stimulation, Chemical
D010434:Pepsin A; D010418:Pentagastrin
Funktsional'nye éffekty pentagastrina i diagnosticheskie vozmozhnosti pentagastrinovogo testa.