Lichen sclerosus et atrophicus in children and young adults.
We performed a retrospective study of 52 children and young adults (average age 18 yrs) with lichen sclerosus et atrophicus. In 56% of patients the eruption was still present after a follow-up of 7.5 years. Younger patients were most likely to show improvement. The histologic appearance of both groups (patients with persistent lesions and those with resolution of lesions) showed classic features of lichen sclerosus et atrophicus: homogenized collagen with an underlying bandlike lymphocytic infiltrate. Epidermal changes such as atrophy, hyperplasia, and follicular plugging were slightly more prominent in patients with persistent lesions. Menarche, pregnancy, and the presence of extragenital lesions had no effect on the prognosis, but since the condition resolved, on average, during adolescence, unknown developmental factors may be implicated.
Helm
K F
KF
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905.
Gibson
L E
LE
Muller
S A
SA
D000293:Adolescent; D000328:Adult; D001284:Atrophy; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008572:Menarche; D012189:Retrospective Studies; D012598:Sclerosis; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D014845:Vulvar Diseases / Q000473:pathology