Lipophilic 99mTc-nitride radiopharmaceuticals as potential myocardial imaging agents.
Monocationic 99mTc-nitrido complexes of a variety of diphosphine ligands have been prepared and the in vivo distribution of such cations has been examined in Sprague-Dawley rats. These complexes show initially high myocardial uptake with subsequent wash-out in this animal model. The lack of myocardial retention can be attributed to the facile in vivo reduction of these cations.
Dilworth
J R
JR
Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, Colchester, England.
Archer
C M
CM
Latham
I A
IA
Kelly
J D
JD
Griffiths
D V
DV
York
D C
DC
Mahoney
P M
PM
Higley
B
B
D000818:Animals; D002855:Chromatography, Thin Layer; D006321:Heart / Q000000981:diagnostic imaging*; D008024:Ligands; D008055:Lipids / Q000737:chemistry; D008297:Male; D015609:Organotechnetium Compounds; D010720:Phosphines; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D008024:Ligands; D008055:Lipids; D015609:Organotechnetium Compounds; D010720:Phosphines