Hippocampal contribution to verbal recent memory following dominant-hemisphere temporal lobectomy.
The effects of hippocampal encroachment in the language dominant-hemisphere were studied in 41 patients who underwent previous temporal lobectomy (TL). Patients undergoing dominant-hemisphere TL including anterior hippocampus (n = 13) performed significantly worse than nondominant TL patients (n = 16) on a verbal learning test (Selective Reminding; p less than or equal to .00001), thereby confirming the sensitivity of this procedure to lateralized temporal-lobe dysfunction. However, no significant difference was present on this or other primary measures of material-specific memory when contrasting dominant TL patients in whom the anterior hippocampus was spared (n = 12) to those in whom anterior hippocampus was resected. These data suggest that more extensive and posterior mesial temporal-lobe resection is not necessarily associated with a greater verbal material-specific memory deficit following dominant-hemisphere temporal lobectomy.
Loring
D W
DW
Department of Neurology, Medical College of Georgia, Augusta 30912-3275.
Lee
G P
GP
Meador
K J
KJ
Smith
J R
JR
Martin
R C
RC
Ackell
A B
AB
Flanigin
H F
HF
D000328:Adult; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology*; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology; D011183:Postoperative Complications / Q000503:physiopathology*; D011612:Psychosurgery; D012691:Serial Learning / Q000502:physiology; D013702:Temporal Lobe / Q000503:physiopathology* / Q000601:surgery*; D014706:Verbal Learning / Q000502:physiology*