[HLA histocompatibility antigens in patients with aortic valve defects].
HLA antigens A, B, C were determined in 61 patients with aortic valve disease and in 263 healthy controls. The patients were divided into two subgroups--with rheumatic fever in anamnesis (N = 24) and without (N = 37). In the whole group of patients with aortic valve disease there was a lower frequency of incidence of HLA A3 in comparison to the control group. In the subgroup with rheumatic fever in anamnesis there was a deficit of HLA A3 and a much more frequent incidence of HLA B17, in the subgroup without rheumatic fever a more frequent incidence of HLA A2, A9, A28, B15 was noted in comparison to the control group. This study shows that in 60% of patients with aortic valve disease the etiology is linked not to rheumatic fever but probably to a connective tissue disorder. A deficit of HLA A3 and presence of B17 can be a risk factor for rheumatic fever.
I Klinika Chorób Wewnetrznych IMW AM, Lodzi.
T
T
Waszyrowski
A
A
Zebrowski
M
M
Krzemińska-Pakuła
J
J
Miś
A
A
Kaczmarek
D000328:Adult; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000276:immunology*; D005260:Female; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D015236:HLA-C Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012213:Rheumatic Fever / Q000150:complications / Q000276:immunology
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens
Antygeny zgodności tkankowej HLA u chorych z wadami zastawki aortalnej.