[The effect of lithium oxybutyrate on the circadian rhythms of the activity and body temperature of rats maintained under different light regimens].
The chronobiological properties of lithium hydroxybutrate were studied in the open field test at the preventive administration of the drug to rats (7 days, 10 mg/kg daily subcutaneously) kept under natural photoperiod of the summer and winter solstice and CT 12:12. It was found that lithium hydroxybutrate can preserve, reveal the lost rhythms and synchronize the available circadian and infradian rhythms of the activity and body temperature of the rats. The degree and direction of this effect depend on the initial rhythmostasis, the time of the drug administration and the regimen of illumination under which the animals are kept.
Zamoshchina
T A
TA
Matveenko
A V
AV
Agarkova
V P
VP
Alekseeva
L P
LP
Saratikov
A S
AS
D000818:Animals; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology; D002909:Chronobiology Phenomena / Q000187:drug effects / Q000502:physiology; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008027:Light; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D009942:Organometallic Compounds / Q000494:pharmacology*; D051381:Rats; D012621:Seasons; D013997:Time Factors
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate; D008094:Lithium
Vliianie oksibutirata litiia na sutochnye ritmy aktivnosti i temperatury tela krys, soderzhashchikhsia na razlichnykh fotorezhimakh.