Desmoplasia in benign and malignant breast disease is characterized by alterations in level of mRNAs coding for types I and III procollagen.
Desmoplasia, the formation of excessive connective tissue surrounding some neoplasms, is a well documented, but incompletely understood phenomenon. To characterize the fibrotic response in benign breast conditions and malignancy, we examined the steady state levels of mRNA coding for types I and III procollagen in mild fibrocystic changes, in fibroadenoma, and in infiltrating ductal carcinoma. The results indicate that in mild fibrocystic change there is a relative increase in type III procollagen mRNA. In contrast, fibroadenoma and carcinoma are characterized by increased levels of type I procollagen mRNA.
Dept. of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903.
S B
SB
Deak
M R
MR
Glaug
R A
RA
Pierce
E
E
Bancila
P
P
Amenta
J W
JW
Mackenzie
R S
RS
Greco
C D
CD
Boyd
D000328:Adult; D000368:Aged; D015152:Blotting, Northern; D001941:Breast Diseases / Q000235:genetics / Q000473:pathology*; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D003238:Connective Tissue / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011347:Procollagen / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D012016:Reference Values
D011347:Procollagen; D012333:RNA, Messenger