Acute renal failure associated with intraperitoneal cisplatin chemotherapy with systemic thiosulfate protection in ovarian cancer patients.
Acute renal failure associated with intraperitoneal cisplatin chemotherapy occurred in 4 courses of treatment each given to one patient, and comprised 3.4% of the total number of intraperitoneal treatment courses. The 4 patients recovered completely, 2 of them after dialysis. Several possible reasons for this complication, which occurred in spite of thiosulphate systemic protection, are considered. Strict adherence to the treatment protocol is mandatory in order to avoid severe nephrotoxicity.
Department of Obstetrics, Gynecology, and Oncology, Sheba Medical Center, Tel Hashomer, Israel.
J
J
Menczer
G
G
Ben-Baruch
S
S
Rizel
H
H
Brenner
D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy*; D013885:Thiosulfates / Q000627:therapeutic use*
D013885:Thiosulfates; D003404:Creatinine; D002945:Cisplatin