Effects of long-term vasodilator therapy on electrocardiographic abnormalities in chronic aortic regurgitation.
Electrocardiographic abnormalities develop in patients with chronic aortic regurgitation (AR). Although vasodilator drugs may reduce left ventricular (LV) volume overload, the effects of such therapy on electrocardiographic abnormalities have not been previously evaluated. Accordingly, electrocardiograms were analyzed before and after double-blind, randomized administration of either hydralazine or placebo in 54 patients with chronic AR. These patients were without limiting symptoms and had preserved ejection fraction on entry in the study. The magnitude of ST-segment depression and Romhilt-Estes point score for LV hypertrophy were assessed. Baseline ST depression and LV hypertrophy scores in the placebo and hydralazine groups were not significantly different. At follow-up, after a mean of 19 +/- 6 months, there was a significant reduction in ST depression in patients taking hydralazine (n = 28) compared with patients given placebo (n = 26): -0.023 +/- 0.044 vs 0.029 +/- 0.055 mV, respectively (p = 0.0001); and in the LV hypertrophy score (-1.1 +/- 2.2 vs 0.9 +/- 2.3 points, respectively; p = 0.002). Hydralazine-treated patients also had significant decreases in LV end-diastolic and end-systolic volume indexes, and a significant increase in ejection fraction. These results suggest that such vasodilator therapy may be beneficial in patients with chronic AR.
Wilson
R
R
Department of Medicine, Oregon Health Sciences University, Portland 97201-3098.
Perlmutter
N
N
Jacobson
N
N
Siemienczuk
D
D
Szlachcic
J
J
Bristow
J D
JD
Cheitlin
M
M
Massie
B
B
Greenberg
B
B
D000328:Adult; D001022:Aortic Valve Insufficiency / Q000188:drug therapy* / Q000503:physiopathology; D002306:Cardiac Volume; D002908:Chronic Disease; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects*; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D006830:Hydralazine / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
D006830:Hydralazine