[LFA-1 defect: a rare granulocyte function disorders as a cause of therapy-resistant omphalitis in newborn infants].
A newborn infant suffered from severe omphalitis resistant to antibiotic therapy. The combination of the symptoms: delayed separation of the umbilical cord, omphalitis, impairment of wound-healing and extreme leukocytosis led to the diagnosis of LFA-1 (leukocyte function antigen)-deficiency, which was confirmed by monoclonal antibodies. The pathophysiology of this disorder is described shortly.
Pädiatrische Abteilung, Altonaer Kinderkrankenhaus, Hamburg.
T
T
Hoek
P
P
Reifferscheid
M
M
Hadam
M
M
Gahr
D000900:Anti-Bacterial Agents; D001424:Bacterial Infections / Q000188:drug therapy / Q000276:immunology*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007231:Infant, Newborn; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology*; D014472:Umbilicus
D000900:Anti-Bacterial Agents; D016169:Lymphocyte Function-Associated Antigen-1
LFA-1-Defekt: Eine seltene Granulozytenfunktionsstörung als Ursache der therapieresistenten Omphalitis des Neugeborenen.