The prevalence of fragile X in a sample of autistic individuals diagnosed using a standardized interview.
The study examined 75 autistic individuals who met DSM-III-R criteria for autistic disorder at 5 years of age. Diagnosis was based on information elicited using a standardized interview for autism. Two of 75 (2.7%) autistic subjects expressed the fragile X marker (Xq27.3) in 40% of cells counted and had other affected family members. Two additional subjects expressed the fragile X anomaly at low rates (1%). These rates are compared with those reported in other studies. Methodological differences, which may underlie the varying rates reported across studies, are discussed.
Piven
J
J
Department of Psychiatry, University of Iowa Hospitals and Clinics.
Gayle
J
J
Landa
R
R
Wzorek
M
M
Folstein
S
S
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D015142:Baltimore / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005600:Fragile X Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D006801:Humans; D015994:Incidence; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D010552:Personality Assessment