Immunohistochemical evidence for the presence of type B monoamine oxidase in histamine-containing neurons in the posterior hypothalamus of cats.
Using a double immunostaining method, we demonstrated that type B monoamine oxidase (MAO-B) immunoreactivity was present in virtually all histamine (HA)-immunoreactive neurons in the posterior hypothalamus of the cat. Not all MAO-B-positive neurons, however, displayed HA immunoreactivity: a minor group of neurons immunoreactive for MAO-B alone was observed in the area dorsolateral to the caudal arcuate nucleus. The results suggest that the degradation of tele-methylhistamine might occur within the intraneuronal structures of histaminergic neurons.
Département de Médecine Expérimentale, INSERM U52, CNRS URA1195, Faculté de Médecine, Université Claude Bernard, Lyon, France.
J S
JS
Lin
P
P
Fort
K
K
Kitahama
P
P
Panula
R M
RM
Denney
M
M
Jouvet
D000818:Animals; D002415:Cats; D006632:Histamine / Q000378:metabolism*; D007034:Hypothalamus, Posterior / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D008995:Monoamine Oxidase / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*
D006632:Histamine; D008995:Monoamine Oxidase