Interstitial pneumonitis associated with "crack" cocaine abuse.
A 33-year-old woman developed acute bilateral pulmonary infiltrates after the intense use of rock cocaine (crack). She subsequently had progressive deterioration of pulmonary function to the point of being ventilator-dependent. Open lung biopsy showed a chronic interstitial pneumonia with extensive accumulation of free silica within histiocytes associated with mild pulmonary fibrosis. This pattern of interstitial pneumonia has not been previously reported in crack users.
Department of Medicine, Robert L. Thompson Strategic Hospital, Carswell AFB, Texas.
A E
AE
O'Donnell
F G
FG
Mappin
T J
TJ
Sebo
H
H
Tazelaar
D000328:Adult; D016578:Crack Cocaine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000175:diagnosis; D012829:Silicosis / Q000209:etiology / Q000473:pathology; D019966:Substance-Related Disorders / Q000150:complications*
D016578:Crack Cocaine