[Anti-basal membrane glomerulonephritis after homologous kidney transplantation in hereditary Alport's nephropathy].
A patient, born in 1968, was found at the age of 9 years to have Alport's syndrome. In his 20th year, when in terminal renal failure, his father's kidney was transplanted into him. 14 months later there was a sudden worsening of his renal function after a varicella infection; for the first time antibodies against the glomerular basal membrane (GBM) were detected. Despite an increase in prednisolone dosage and 6 plasmaphereses chronic haemodialysis again became necessary. Renal biopsy revealed necrotizing intra- and extracapillary glomerulonephritis. Simultaneously there was a raised anti-NC-1-antibody titre (1:80) in the serum. After removal of the transplant the titre fell to normal. The NC-1 antigen, a component of the GBM in healthy persons, may be absent in Alport's syndrome. An analysis of the few cases of anti-GBM glomerulonephritis in renal transplants of patients with Alport's syndrome may make it possible to recognize factors which precipitate or favour this form of glomerulonephritis.
Abteilung für Nephrologie, Universität Düsseldorf.
D
D
Bach
A
A
Peters
H
H
Röwemeier
S
S
Degenhardt
U
U
Helmchen
B
B
Grabensee
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000209:etiology*; D001485:Basement Membrane / Q000276:immunology; D002644:Chickenpox / Q000150:complications; D005921:Glomerulonephritis / Q000209:etiology*; D006801:Humans; D007668:Kidney / Q000276:immunology*; D016030:Kidney Transplantation; D008297:Male; D009394:Nephritis, Hereditary / Q000601:surgery*
D001323:Autoantibodies
Antibasalmembran-Glomerulonephritis nach Verwandtennierentransplantation bei hereditärer Nephropathie Alport.