Coordinate interactions of protein tyrosine kinases and protein tyrosine phosphatases in T-cell receptor-mediated signalling.
T-cell receptor stimulation leads to a rapid increase in tyrosine phosphorylation which is regulated by both the CD45 transmembrane protein tyrosine phosphatase and by intracellular protein tyrosine kinases. The Src-family members, Fyn and Lck, have been implicated in T-cell receptor signalling and may be regulated by CD45.
Washington University School of Medicine, St Louis, Missouri.
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Shaw
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Thomas
D000818:Animals; D006801:Humans; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction
D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases; D017027:Protein Tyrosine Phosphatases