[Possibilities for optimizing radiotherapy of cervix cancers by measuring the enzyme peak of GPI after initial irradiation].
Following the first irradiation with a dose of 1.6 respectively 2 Gy we determined the activity of glucose-6-phosphate isomerase (GPI) and of creatine kinase in intervals of 30 minutes for 24 hours. In all patients we could observe peaks of GPI-activity 15.5 to 19.5 hours after irradiation corresponding to tumour volume and grading. Frequency depends on present lymph node metastases detected by lymphography and/or computed tomography. Possible reasons have been discussed by the viewpoint of radiation biology and the meaning with respect to an optimal radiation treatment.
Klinik und Poliklinik für Onkologie, Humboldt-Universität zu Berlin.
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Below
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Tunak
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Dallüge
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Kuchenbecker
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Tosch
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D004789:Enzyme Activation / Q000528:radiation effects; D005260:Female; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood*; D006801:Humans; D015182:Lymphatic Irradiation; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D002583:Uterine Cervical Neoplasms / Q000201:enzymology / Q000473:pathology / Q000532:radiotherapy*
D014408:Biomarkers, Tumor; D005956:Glucose-6-Phosphate Isomerase
Möglichkeiten der Optimierung der Strahlentherapie von Zervixkarzinomen durch Messung des Enzympeaks der GPI nach der ersten Bestrahlung.