A canine model of cyclosporine enhanced ischemic renal injury.
Clinical reports of increased graft primary non function in patients receiving cyclosporine in whom the anastomosis time is prolonged (greater than 30 minutes) suggest a synergism between the nephrotoxic effects of cyclosporine and the ischaemia occurring during transplantation. Using unilaterally nephrectomised greyhound dogs, sixty minutes ischaemia and cyclosporine 10 mg./kg./day we have produced an animal model of cyclosporine enhanced ischaemia renal failure. Structural and functional data suggests the proximal tubule is the main site of injury.
Creagh
T A
TA
Department of Surgery, Beaumont Hospital, Dublin, Ireland.
Broe
P J
PJ
Murphy
D M
DM
McLean
P A
PA
Tormey
W
W
Dolan
J
J
Leader
M
M
Walshe
J J
JJ
Bouchier-Hayes
D J
DJ
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D007511:Ischemia / Q000209:etiology* / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects / Q000503:physiopathology; D009392:Nephrectomy; D013997:Time Factors
D016572:Cyclosporine