[Vitamin E, ubiquinone and ubiquinone-dependent enzymes in experimental myocarditis].
It is shown that a day after introduction of adrenaline which evokes experimental focal myocarditis the level of ubiquinone and vitamin E content in the myocardial mitochondria increases by 56.8 and 122%, respectively. Succinate-ubiquinone-reductase activity in mitochondria remains practically unchanged, while NADH-ubiquinone-reductase activity considerably falls. 5 days after the focal myocarditis reproduction the content of ubiquinone and NADH-ubiquinone-reductase activity of mitochondria return to the norm, while the vitamin E amount remains higher than in intact animals. 24h after adrenaline introduction the level of succinate-ubiquinone-reductase activity of blood leucocytes considerably grows. It is not normalized even on the 5th day after adrenaline administration. It is supposed that the level of this activity may be an index showing development of the focal myocarditis.
Kuz'menko
I V
IV
Kunitsa
N I
NI
Kovalenko
V N
VN
Donchenko
G V
GV
D000818:Animals; D042963:Electron Transport Complex II; D004837:Epinephrine / Q000633:toxicity; D008297:Male; D008929:Mitochondria, Heart / Q000201:enzymology / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism*; D009205:Myocarditis / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D014451:Ubiquinone / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism*
D009097:Multienzyme Complexes; D014451:Ubiquinone; D014810:Vitamin E; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase; D004837:Epinephrine
Vitamin E, ubikhinon i ubikhinonzavisimye fermenty pri éksperimental' nom miokardite.