The relationship between ethanol-induced hyperglycemia and hypothermia: evidence of genetic correlation.
The hyperglycemic and hypothermic responses to acute ethanol exposure (0, 2, 4, 6 g/kg, intraperitoneally) were examined in non-fasted mice selectively bred for sensitivity (COLD line) or insensitivity (HOT line) to ethanol-induced hypothermia. Blood samples and rectal temperatures were obtained immediately before injection and hourly for 4 hr after injection. As expected, COLD mice demonstrated greater and more prolonged reductions in body temperature than HOT mice, especially at the 4 g/kg dose (HOT: -2.58 degrees C, COLD: -5.08 degrees C). Ethanol produced significant dose-dependent elevations in blood glucose levels over the 4-hr sampling period in both lines. The greatest elevations in blood glucose levels were seen at 4 g/kg, with COLD mice (mean = 225.1 mg/dl) showing significantly greater elevations in blood glucose levels compared to HOT mice (mean = 177.0 mg/dl). These results support the hypothesis that the thermic and glycemic effects produced by ethanol are due to related neural processes that share a common genetic component.
Risinger
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Oregon Health Sciences University, Department of Medical Psychology, Portland 97201-3098.
Cunningham
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D006943:Hyperglycemia / Q000139:chemically induced* / Q000235:genetics; D007035:Hypothermia / Q000139:chemically induced* / Q000235:genetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011897:Random Allocation
D000431:Ethanol