[Synthesis and antiparasitic activity of various N-acetylacetates of nitrogen heterocycles].
The synthesis and the study of the antiparasitic activity of various heterocyclic N-ethylacetates derived from substituted derivatives of piperazine, benzimidazole and benzotriazole do not show antiparasitic property. A slight activity on Entamoeba histolytica and Trichomonas vaginalis is noted with the nitro derivatives of benzimidazole and benzotriazole.
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud, Châtenay-Malabry.
J R
JR
Goma
P
P
Gayral
A
A
Danan
S
S
Kirkiacharian
D000085:Acetates / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D010271:Parasites / Q000187:drug effects*; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology
D000085:Acetates; D001562:Benzimidazoles; D010879:Piperazines; D014230:Triazoles; C012771:benzotriazole
Synthèse et activité antiparasitaire de divers N-éthylacétates d'hétérocycles azotés.