Prognostic indicators for the development of AIDS in HIV antibody positive haemophiliac patients: results of a three-year longitudinal study.
In February 1986, 40 out of 75 adult patients with haemophilia A attending St. James's University Hospital were human immunodeficiency virus (HIV) antibody positive. Over a three-year period these patients were prospectively studied with regard to possible prognostic indicators for the development of the acquired immune deficiency syndrome (AIDS). Using the Centres for Disease Control (CDC) classification of HIV infection, 17 patients (42.5%) developed group 4 disease during this time, giving an actuarial three-year progression rate of 44%, and 5 patients (12.5%) died. The following parameters measured at recruitment were found independently to predict progression to AIDS: a serum beta 2-m level of greater than 3.5 mg/l, (chi 2 = 15.95, P less than 0.001), a serum IgA level of greater than 4.5 milligram(s) (chi 2 = 6.08, P less than 0.02) and p24 antigenaemia (chi 2 = 5.7, P less than 0.05). The actuarial three-year progression rate in those patients abnormal by two or more of these parameters was 100% (n = 7), compared to only 7% in patients who were normal by all three values (n = 15). CD4+ lymphocyte counts and CD4+:CD8+ ratios were significantly lower in HIV positive compared with HIV negative patients (P less than 0.01), but did not predict the development of AIDS.
Department of Haematology, St. James's University Hospital, Leeds.
G M
GM
Smith
M A
MA
Forbes
J
J
Cooper
T
T
Bradley
M H
MH
Hambling
E H
EH
Cooper
B A
BA
McVerry
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016516:CD4-CD8 Ratio; D016655:HIV Core Protein p24 / Q000097:blood; D006679:HIV Seropositivity / Q000150:complications*; D006467:Hemophilia A / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D065227:Transfusion Reaction; D001613:beta 2-Microglobulin / Q000378:metabolism
D015415:Biomarkers; D016655:HIV Core Protein p24; D007136:Immunoglobulins; D001613:beta 2-Microglobulin