Vitreous replacement by gas as a therapeutic modality in bacterial endophthalmitis.
We investigated vitreous replacement by long-lasting gas in the management of severe Staphylococcus aureus endophthalmitis in 19 rabbits randomized for vitrectomy (9 animals) and for vitrectomy followed by replacement of the vitreous by a 20% perfluoropropane-80% air mixture (10 animals). Both groups received systemic antibiotics and achieved comparable intraocular antibiotic levels. Clinically and histopathologically, gas-filled eyes demonstrated less inflammation than did eyes without gas (P less than 0.01). Replacement of vitreous by gas offers an effective adjunct to vitrectomy by eliminating a culture medium, preventing vitreous abscess formation, enabling fundus visualization, and delaying the onset of retinal detachment.
Department of Ophthalmology, University of Texas Medical Branch, Galveston 77550.
A M
AM
Mansour
E
E
Ferguson
H
H
Lucia
M
M
Rajashekhar
H
H
Li
T
T
Margo
D000388:Air; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D002437:Cefazolin / Q000097:blood / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D009877:Endophthalmitis / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D015818:Eye Infections, Bacterial / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D005466:Fluorocarbons / Q000008:administration & dosage*; D011817:Rabbits; D011897:Random Allocation; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism / Q000382:microbiology / Q000473:pathology
D005466:Fluorocarbons; C042852:perflutren; D002437:Cefazolin