The anticonvulsive effect of BCH 325 is age dependent.
The two different experimental approaches which were applied to study the anticonvulsive effectiveness of BCH 325, a des-tyrosine derivative of bovine beta-casomorphin-(5), in immature (22-day-old) and mature (7-week-old) female rats revealed that the peptide was able to protect mature females from electrically induced seizures and that it had no effect on pentylenetetrazol-induced convulsions. As opposed to this, immature animals were protected against chemically induced seizures but no effect was found using electrically induced seizures.
Becker
A
A
Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, Germany.
Grimm
R
R
Grecksch
G
G
Matthies
H
H
D000367:Age Factors; D000818:Animals; D000927:Anticonvulsants; D004597:Electroshock; D004723:Endorphins / Q000494:pharmacology*; D005260:Female; D010433:Pentylenetetrazole; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000517:prevention & control
D000927:Anticonvulsants; D004723:Endorphins; D010446:Peptide Fragments; C059556:beta-casomorphin, des-Tyr-; D010433:Pentylenetetrazole