Lack of evidence of ketoprofen kinetic changes during the oestrous cycle in rats.
This study was designed to document possible changes in ketoprofen kinetics in female rats related to the stage of the oestrous cycle. At 3 different stages of the oestrous cycle (proestrus, oestrus or dioestrus), 3 different groups of 5 animals each received a single 10 mg/kg intraperitoneal dose of ketoprofen and blood samples were taken at 0.25, 0.5, 0.75, 1, 2, 4, 8, 12 and 24 h after administration. Ketoprofen pharmacokinetic parameters (Cmax, T1/2 alpha and beta, AUC and MRT) were calculated. Our data did not reveal any significant differences in ketoprofen kinetics related to the oestrous cycle.
Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, France.
B
B
Bruguerolle
G
G
Bouvenot
D000818:Animals; D004971:Estrus / Q000378:metabolism*; D005260:Female; D007660:Ketoprofen / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D007660:Ketoprofen