Synthesis and biodistribution of 123I N-(2-aminoethyl)-5-iodo-2-pyridinecarboxamide (Ro 43-0463), a monoamine oxidase B inhibitor.
N-(2-Aminoethyl)-5-iodo-2-pyridinecarboxamide (Ro 43-0463) was radiolabeled with 123I in 22% radiochemical yield by anionic isotopic exchange in acidic medium. Biodistribution studies of this radioligand in rats showed peak brain uptake of 0.50% of the injected dose at 30 min and slow washout over 60 min.
Medi-Physics Inc., Emeryville, CA 94608.
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D000818:Animals; D005260:Female; D007457:Iodine Radioisotopes; D008996:Monoamine Oxidase Inhibitors / Q000493:pharmacokinetics*; D010848:Picolinic Acids / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D008996:Monoamine Oxidase Inhibitors; D010848:Picolinic Acids; C071353:N-(2-aminoethyl)-5-iodo-2-pyridinecarboxamide