Pergolide presynaptically inhibits calcium-stimulated release of gamma-aminobutyric acid.
The release of gamma-aminobutyric acid (GABA) in rat dorsolateral striatum was studied using in vivo microdialysis. Dialysis was conducted 2 days after probe implantation in awake, freely moving rats using a modified Ringer solution. Calcium induced a reversible increase in GABA release that was abolished by tetrodotoxin but was only slightly attenuated by a maximally effective dose of pergolide, a D2 receptor agonist. It was thus concluded that pergolide inhibits calcium-stimulated release of GABA presynaptically by a mechanism distinct from that of tetrodotoxin.
Institute of Arctic Biology, University of Alaska, Fairbanks 99775-0180.
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KL
Drew
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Ungerstedt
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D005110:Extracellular Space / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology; D009994:Osmolar Concentration; D010479:Pergolide / Q000494:pharmacology*; D051381:Rats; D013569:Synapses / Q000187:drug effects*; D013779:Tetrodotoxin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D010479:Pergolide; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid; D008274:Magnesium; D002118:Calcium