Biologic fate of cryopreserved human saphenous allografts: case report and hypothesis.
A femoroperoneal bypass using a cryopreserved human saphenous allograft was performed on a patient who presented with critical ischemia of the left lower extremity. The patient died of myocardial infarction 48 hours later and the graft was examined histologically. There was karryorhexis and focal neutrophilic infiltrate in the media underlying a layer of fibrin on the intimal surface. Immunoperoxidase studies showed nonspecific luminal deposition of immunoglobulins and fibrinogen. The histologic changes that occur in cryopreserved venous allografts are similar in experimental and human material and may be the result of anoxia of the vessel wall rather than immunologic mechanisms.
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City.
W W
WW
Hoover
T F
TF
Kresowik
R T
RT
Cook
D000368:Aged; D000369:Aged, 80 and over; D015925:Cryopreservation; D005263:Femoral Artery / Q000601:surgery; D006801:Humans; D007511:Ischemia / Q000601:surgery; D007866:Leg / Q000098:blood supply; D008297:Male; D012501:Saphenous Vein / Q000473:pathology / Q000637:transplantation; D013997:Time Factors; D014184:Transplantation, Homologous