Evaluation of the hepatotoxic potential of minocycline.
Minocycline (25 to 100 micrograms/g) dose dependently increased serum glutamic oxalacetic transaminase, urea, and bilirubin levels, and the hepatic triglyceride content in mice. In animals pretreated with phenobarbital to enhance minocycline metabolism, the effects on liver triglycerides were attenuated, while the changes in serum glutamic oxalacetic transaminase, urea, and bilirubin were enhanced. It is concluded that part of the toxic effects of minocycline may be produced by a metabolite of minocycline.
Böcker
R
R
Institute for Pharmacology and Toxicology, University of Erlangen-Nürnberg, Federal Republic of Germany.
Estler
C J
CJ
Ludewig-Sandig
D
D
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000503:physiopathology*; D004318:Doxycycline / Q000633:toxicity; D005260:Female; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008911:Minocycline / Q000633:toxicity*; D013752:Tetracycline / Q000633:toxicity; D014280:Triglycerides / Q000378:metabolism; D014508:Urea / Q000097:blood
D014280:Triglycerides; D014508:Urea; D001219:Aspartate Aminotransferases; D013752:Tetracycline; D008911:Minocycline; D004318:Doxycycline; D001663:Bilirubin