Dopamine receptors in the ventral tegmental area affect motor, but not motivational or reflexive, components of copulation in male rats.
Microinjection of apomorphine into the ventral tegmental area (VTA) of male rats was previously shown to delay the onset of copulation and slow its rate, presumably by stimulating impulse-regulating autoreceptors on cell bodies of the A10 mesocorticolimbic dopamine tract. Such stimulation would be expected to slow the firing rate of these neurons and, thereby, to impair locomotion and/or motivational processes. The present experiments tested whether the delayed onset and slowed rate of copulation were related to deficits in motor performance, sexual motivation, and/or genital reflexes. In X-maze tests the speed of running to all 4 goal boxes was slowed; however, the percentage of trials on which the male chose the female's goal box was not decreased. Examination of videotaped copulation tests revealed that the male showed fewer complete copulatory behaviors (mounts, intromissions, and ejaculations), but more misdirected or incomplete copulatory attempts after apomorphine in the VTA. There were also fewer scores of active, as opposed to inactive, behaviors, and the onset and rate of copulation were slowed. The total number of female directed behaviors was not different in apomorphine tests, compared to vehicle. Finally, tests of ex copula genital reflexes revealed no significant effects of apomorphine in the VTA on erections, penile movements, or seminal emissions. These data suggest a role of the VTA in the motor aspects and/or sensorimotor integration of copulation. Sexual motivation and ex copula genital reflexes appeared to be unaffected by apomorphine in the VTA.
Department of Psychology, State University of New York, Buffalo, Amherst 14260.
E M
EM
Hull
M S
MS
Weber
R C
RC
Eaton
R
R
Dua
V P
VP
Markowski
L
L
Lumley
J
J
Moses
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D003307:Copulation; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects; D005260:Female; D008297:Male; D008845:Microinjections; D009042:Motivation; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D012018:Reflex / Q000187:drug effects*; D012661:Semen / Q000378:metabolism; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013681:Tegmentum Mesencephali / Q000187:drug effects / Q000502:physiology*
D011954:Receptors, Dopamine; D001058:Apomorphine