The effect of furosemide on the endocochlear potential in ears with experimentally induced endolymphatic hydrops.
The endocochlear potential (EP) was measured in 38 guinea pigs with experimentally induced endolymphatic hydrops at the 3rd, 6th, 12th and 24th postoperative weeks, and the effects of furosemide (FUR, 50 or 80 mg/kg) on the EP were examined. A time-related reduction of the EP from the normal value and increased susceptibility to FUR were disclosed in the hydropic animals. Furthermore, 24-week animals given 80 mg/kg FUR showed a significantly slower recovery rate of the EP than the other groups, indicating impairment of the strial function progressive with post-operative time. The negative component of the EP was considered to be unimpaired until at least 12 weeks after the surgery.
Ito
Z
Z
Department of Otolaryngology, University Hospital, Tsukuba, Japan.
Kusakari
J
J
Takeyama
M
M
Nishikawa
N
N
Hara
A
A
Nakata
H
H
D000818:Animals; D003051:Cochlea / Q000187:drug effects*; D015834:Cochlear Diseases / Q000473:pathology / Q000503:physiopathology*; D004487:Edema / Q000473:pathology / Q000503:physiopathology; D004711:Endolymphatic Duct / Q000473:pathology / Q000503:physiopathology*; D005071:Evoked Potentials / Q000187:drug effects; D005665:Furosemide / Q000494:pharmacology*; D006168:Guinea Pigs; D013316:Stria Vascularis / Q000473:pathology / Q000502:physiology
D005665:Furosemide