Influence of 3-methylcholanthrene on the redox-state of liver and red muscles in vivo.
It was observed, that following an injection of 3-methylcholanthrene (MC), the tissue redox-state potential is modified expressively both in liver and in red muscles. In the liver in the first day an oxidosis develops, which is followed by redosis, but in the muscle a redosis can be observed already in the first day. It is a meaningful fact, that MC influences biochemical processes in the early phase of its effect not only in the liver but also in the red muscle. By reason of this data the possibility of a prevention of the MC influence by adequate redox agents might also be arised.
Biological Institute, University Medical School, Pécs, Hungary.
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Tigyi
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Práger
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Puppi
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Zsoldos
D000818:Animals; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008748:Methylcholanthrene / Q000008:administration & dosage / Q000494:pharmacology*; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D011199:Potentiometry; D051381:Rats
D008748:Methylcholanthrene