[The contraceptive efficacy and mechanism of action of combinations of ethinyl estradiol and norethisterone acetate].
The purpose of the study was to establish the optimal combinations of ethynilestradiol and norethysterone acetate exhibiting a high contraceptive activity. It was shown that the ratio of 1:20 (ethynilestradiol 0.04 mg/kg and norethysterone acetate 0.8 mg/kg) is characterized by a high contraceptive efficacy. The inhibitory effect on the incretion of lutropin and follitropin leading to the change of the process of oogenesis and gravidary reorganization of the endometrium underlies probably the mechanism of action.
Makusheva
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VP
D000818:Animals; D003277:Contraceptives, Oral, Combined; D004353:Drug Evaluation, Preclinical; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000187:drug effects / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077563:Norethindrone Acetate; D009865:Oocytes / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D051381:Rats
D003277:Contraceptives, Oral, Combined; D004997:Ethinyl Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D000077563:Norethindrone Acetate; D009640:Norethindrone
Kontratsevtivnaia éffektivnost' i mekhanizm deĭstviia kombinatsiĭ étniléstradiola i norésterona atsetata.