In vitro and in vivo studies of ME1228, a new parenteral cephalosporin with potent activity against Pseudomonas aeruginosa.
The therapeutic effect of ME1228, a new parenteral cephalosporin, was compared with that of broad-spectrum cephems in normal and neutropenic mice infected with various species of bacteria. The results showed that ME1228 was more active than were the other cephems against infections with various pathogens.
Department of Microbiology, Toho University School of Medicine, Tokyo, Japan.
S
S
Miyazaki
Y
Y
Miyazaki
A
A
Tsuji
M
M
Nishida
S
S
Goto
D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control*; D002511:Cephalosporins / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D002511:Cephalosporins; C061366:ME 1228