Cutaneous mastocytosis after autologous bone marrow transplantation.
A 41-year-old male patient developed cutaneous mastocytosis 3 months after autologous bone marrow transplantation (ABMT). The ABMT was performed as part of consolidation treatment for a high-grade malignant non-Hodgkin's lymphoma. There was no evidence for systemic mastocytosis. Recurrence of the lymphoma could not be shown. Mast cell proliferation frequently coexists with dysplastic and neoplastic disorders of myeloid and, more rarely, of lymphoid cells. Mast cells are growth factor responsive and ultimately originate from the pluripotent hematopoietic stem cell. After autologous bone marrow transplantation, hematological reconstitution may in rare cases lead to an abnormal proliferation of mast cells possibly due to unbalanced production of growth factors.
Department of Hematology, A.Z. St Jan, Brugge, Belgium.
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Van Hoof
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Criel
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Louwagie
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Vanvuchelen
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000601:surgery; D008297:Male; D008407:Mast Cells / Q000473:pathology; D014182:Transplantation, Autologous; D014582:Urticaria Pigmentosa / Q000209:etiology* / Q000473:pathology