Chondrocytes may activate macrophages.
It is demonstrated that conditioned media of articular chondrocytes cultured with Bacilli Calmette-Guérin are capable of activating macrophages. This activation reaches different levels and is expressed both by different cell survival and enhanced synthesis of glycosaminoglycans that remain cell-associated (exp. group III) or are secreted (exp. group II). The reason of these variances is unknown. - A protein factor is supposed to be present in variable concentration or activity. Interleukin-1 could not be correlated with the results.
Institute of Pathology, Friedrich Schiller University, Jena, F.R.G
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Kittlick
D000818:Animals; D002358:Cartilage, Articular / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006025:Glycosaminoglycans / Q000378:metabolism; D008262:Macrophage Activation / Q000502:physiology*; D008264:Macrophages / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D010529:Peritoneal Cavity / Q000166:cytology; D011817:Rabbits
D006025:Glycosaminoglycans