Effect of fission-neutron dose rate on the induction of a tumor-associated antigen in human cell hybrids (HeLa X skin fibroblasts).
The HeLa X skin fibroblast human cell hybrid system has been used to study the effect of fission-neutron dose rate on the induction of neoplastic transformation. Previously published data using neutrons from the JANUS reactor at Argonne National Laboratory are compared with some preliminary data obtained on the TRIGA reactor at the Armed Forces Radiobiology Research Institute. Comparable results were obtained on both reactors, both in terms of absolute values of transformation frequency and in terms of magnitude of the inverse dose-rate effect (a factor of 2.5 to 3).
Department of Radiological Sciences, University of California Irvine 92717.
J L
JL
Redpath
C
C
Sun
W F
WF
Blakely
D000951:Antigens, Neoplasm / Q000032:analysis*; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006367:HeLa Cells; D006801:Humans; D006822:Hybrid Cells; D009502:Neutrons
D000951:Antigens, Neoplasm