The Stockholm experience with pancreatic transplantation using enteric exocrine diversion.
Between April 1974 and June 1990, 128 pancreatic transplantations were performed. Of these 117 were with pancreatico-enterostomy. In four consecutive series of combined transplantations in uraemic diabetic patients the 1-year graft survival rate have successively improved (27%, 65%, 68% and 73%). In three similar series of single pancreatic transplantations the results also improved but still remained inferior (0%, 33% and 33%). In a series of combined transplantations performed in preuraemic diabetic patients the 1-year actuarial graft survival rate was only 25%. The results with pancreatic transplantation with pancreatico-enterostomy are now satisfactory. However, immunological loss graft function still constitute a major problem in the non- or pre-uraemic recipients. The metabolic control in patients with functioning grafts is normal or near-normal in the majority of patients followed for at least 1 year.
Department of Transplantation Surgery, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
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G
Tydén
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A
Tibell
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J
Bolinder
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J
Ostman
C G
CG
Groth
D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000601:surgery; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D016035:Pancreas Transplantation / Q000379:methods; D012189:Retrospective Studies; D013548:Sweden; D016896:Treatment Outcome; D014511:Uremia / Q000601:surgery