[Recent developments in the pharmacology and clinical use of pentazocine].
Pentazocine, an agonist-antagonist of opioid receptor, has been used widely in Japan especially for the control of acute pain. This is because of the tight regulation on the use of narcotics in Japan. Cases of addiction to pentazocine, however, have been observed and in 1990 the drug was designated as a psychomimetic drug of the second degree. Special attention should be paid in storing the drugs of this category in hospitals. In this short review on pentazocine, the pharmacology and clinical use of pentazocine were reviewed including nature of agonist-antagonist drug, potentiality for addiction, pharmacokinetics, and its effect on central nervous, respiratory and circulatory systems. Toxic manifestations after excess doses of pentazocine as well as the local tissue change in response to its repeated injections were also reviewed.
Department of Anesthesiology, University of Tokyo Faculty of Medicine.
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Sugai
D006801:Humans; D010423:Pentazocine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
D010423:Pentazocine