Changes in plasma lipids and abnormal lipoproteins in a patient with drug-induced cholestatic hepatitis.
Changes in plasma lipids and abnormal lipoproteins in a patient with ticlopidine hydrochloride-induced hepatitis were studied. Total cholesterol, free cholesterol and phospholipids increased markedly during cholestasis. Lipoprotein electrophoresis showed a large lipoprotein-X band and a relatively small alpha-lipoprotein band. As cholestatic hepatitis improved, all plasma lipids were progressively decreased. A broad band of abnormal alpha-lipoprotein appeared for the first time with the decrease in the lipoprotein-X band. Both abnormal lipoproteins decreased further and eventually disappeared. The appearance of abnormal alpha-lipoprotein was accompanied by changes in apoproteins. These findings suggest that abnormal alpha-lipoprotein might be an intermediate metabolite of lipoprotein-X.
First Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan.
K
K
Miyahara
N
N
Kasahara
Y
Y
Kondo
Y
Y
Imai
F
F
Matuzaki
D000368:Aged; D001059:Apoproteins / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000150:complications / Q000209:etiology; D002779:Cholestasis / Q000097:blood* / Q000139:chemically induced / Q000150:complications; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008073:Lipoprotein-X / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D013988:Ticlopidine / Q000009:adverse effects
D001059:Apoproteins; D008055:Lipids; D008073:Lipoprotein-X; D008074:Lipoproteins; D013988:Ticlopidine