No effect of the long-acting somatostatin analogue octreotide in patients with insulinoma.
The efficacy of subchronic (3 weeks) treatment with the long-acting somatostatin analogue octreotide was studied in four patients with symptomatic benign insulinoma. No clinical or biochemical effect on serum glucose, insulin, C-peptide or glucagon was observed in all four patients despite clearly detectable serum levels of octreotide. The resistance to octreotide therapy in these patients might be explained by the absence of somatostatin analogue receptors on their tumours.
Department of Internal Medicine and Endocrinology, University Hospital Utrecht, The Netherlands.
R
R
Timmer
J C
JC
Koningsberger
D W
DW
Erkelens
J H
JH
Thijssen
C J
CJ
Lips
H P
HP
Koppeschaar
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007328:Insulin / Q000097:blood; D007340:Insulinoma / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000097:blood / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000601:surgery
D001786:Blood Glucose; D007328:Insulin; D015282:Octreotide