Treatment of metastatic para-aortic paraganglioma by surgery, radiotherapy and I-131 mIBG.
A patient with a malignant, functioning, aortico-sympathetic paraganglioma and a solitary bone metastasis causing paraplegia was treated by spinal decompression, irradiation of the metastasis, surgical excision of the primary tumour and systemic I-131 meta-iodobenzyl-guanidine (mIBG). Sixteen months after treatment there was no clinical, radiological or biochemical evidence of residual disease and neurological function was restored. The case supports the use of combined treatment incorporating mIBG in patients with metastatic neuroendocrine tumours which demonstrate mIBG uptake.
Ball
A B
AB
Academic Surgical Unit, Royal Marsden Hospital, London, UK.
Tait
D M
DM
Fisher
C
C
Sinnett
H D
HD
Harmer
C L
CL
D019797:3-Iodobenzylguanidine; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000627:therapeutic use*; D007796:Laminectomy; D008297:Male; D008875:Middle Aged; D010220:Para-Aortic Bodies; D010235:Paraganglioma / Q000150:complications / Q000556:secondary / Q000628:therapy*; D013117:Spinal Cord Compression / Q000209:etiology; D013125:Spinal Neoplasms / Q000150:complications / Q000556:secondary / Q000628:therapy*; D013565:Sympatholytics / Q000627:therapeutic use
D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013565:Sympatholytics; D019797:3-Iodobenzylguanidine