Alteration of proto-oncogene c-fos expression in neonatal estrogenized BALB/c female mice & murine cervicovaginal tumor LJ6195.
Experiments were performed to determine the effect of neonatal estrogen treatment on the expression of the proto-oncogene c-fos in the BALB/c mouse cervicovaginal tract. Estradiol induces the expression of c-fos in the normal mouse cervicovaginal tract. However, c-fos expression was not stimulated by estradiol in the cervicovaginal tracts of mice that received neonatal estrogen treatment. In addition, the level of expression of c-fos by the estrogen- and progesterone-induced murine cervicovaginal LJ6195 tumor was similar to that in the normal vaginal tract following estradiol stimulation and was not regulated by estradiol.
Scrocchi
L A
LA
Department of Gynecology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Jones
L A
LA
D000818:Animals; D000831:Animals, Newborn; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012016:Reference Values; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology; D014621:Vagina / Q000378:metabolism; D014625:Vaginal Neoplasms / Q000378:metabolism* / Q000473:pathology
D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D004958:Estradiol