[Studies on the enteropathogenic mechanism of non-O1 Vibrio cholerae. II. Lethality, adhesion, colonization and cytopathogenicity of enteropathogenic strains].
Lethality, adhesion, colonization, hemagglutinable activity, invasiveness and cytopathogenicity of non-O1 V. cholerae were compared between enteropathogenic and non-enteropathogenic strains. The following results were obtained. 1) Minimum lethal doses (MLD) of enteropathogenic strains were significantly lower than those of non-enteropathogenic strains. 2) There were no differences in adhesive and hemagglutinating activities between enteropathogenic and non-enteropathogenic strains. 3) A greater majority of enteropathogenic strains showed cytopathogenic effect on HEp 2 cells, but non-enteropathogenic strains did not. 4) Regardless of enteropathogenicity of viable cells, none of the 13 strains examined were found to be invasive to HEp 2 cells. These results suggest that adhesion and colonization do not draw a clear distinction between enteropathogenic and non-enteropathogenic strains, and that both lethal and cytopathogenic activities of these organisms are correlated with enteropathogenicity.
Toyama Institute of Health.
Y
Y
Gyobu
H
H
Kodama
S
S
Sato
D000818:Animals; D001422:Bacterial Adhesion; D002478:Cells, Cultured; D015169:Colony Count, Microbial; D006384:Hemagglutination; D007422:Intestines / Q000382:microbiology; D051379:Mice; D008813:Mice, Inbred ICR; D011817:Rabbits; D014734:Vibrio cholerae / Q000254:growth & development / Q000472:pathogenicity*