Disseminated histoplasmosis in a SIV-infected rhesus monkey.
Disseminated histoplasmosis due to Histoplasma capsulatum was diagnosed in a rhesus monkey inoculated with simian immunodeficiency virus (SIV). Immunohistochemical staining of tissues for viral core antigens revealed that those macrophages that expressed viral antigen contained few or no fungal organisms, while those that were filled with fungal organisms did not express viral antigen. This is a previously undocumented condition in a SIV-infected macaque, and suggests that SIV infection of individual macrophages is not the cause of macrophage dysfunction in SIV infections.
Department of Pathology, Delta Regional Primate Research Center, Tulane University, Covington, LA 70433.
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Baskin
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000150:complications / Q000662:veterinary*; D007150:Immunohistochemistry; D008253:Macaca mulatta; D008264:Macrophages / Q000382:microbiology; D008992:Monkey Diseases; D009894:Opportunistic Infections / Q000150:complications / Q000662:veterinary*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications*; D015302:Simian Immunodeficiency Virus / Q000276:immunology
D000956:Antigens, Viral