Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice.
Neutralization of interleukin 4 (IL-4) at the time of infection with Leishmania major allowed susceptible BALB/c mice to heal. Recombinant IL-4, however, had little effect on the course of L. major infection in resistant C57BL/6 mice, nor did coinfection with Nippostrongylus brasiliensis, despite marked elevation of endogenous IL-4 levels.
Department of Medicine, University of California, San Francisco 94143.
M D
MD
Sadick
N
N
Street
T R
TR
Mosmann
R M
RM
Locksley
D000818:Animals; D007371:Interferon-gamma / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology*; D007895:Leishmania tropica; D016773:Leishmaniasis, Cutaneous / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009349:Nematode Infections / Q000276:immunology; D009559:Nippostrongylus
D015847:Interleukin-4; D007371:Interferon-gamma