Long-term toxicity/carcinogenicity study of calcium lactate in F344 rats.
The long-term toxicity/carcinogenicity of calcium lactate, a food additive, was examined in F344 rats. Calcium lactate was given ad lib. in the drinking-water at levels of 0, 2.5 or 5% to groups of 50 male and 50 female rats for two years. No clear toxic lesion was specifically caused by long-term administration of calcium lactate. No significant dose-related increase was found in the incidences of tumours in any organ or tissue. The results indicated that calcium lactate had neither toxic nor carcinogenic activity in F344 rats.
Division of Pathology, Biological Safety Research Center, National Institute of Hygienic Sciences, Tokyo, Japan.
A
A
Maekawa
Y
Y
Matsushima
H
H
Onodera
M
M
Shibutani
J
J
Yoshida
Y
Y
Kodama
Y
Y
Kurokawa
Y
Y
Hayashi
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005503:Food Additives / Q000633:toxicity*; D007773:Lactates / Q000633:toxicity*; D019344:Lactic Acid; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors
D005503:Food Additives; D007773:Lactates; D019344:Lactic Acid