Synthetic polymers seeded with chondrocytes provide a template for new cartilage formation.
A new approach for tissue creation using synthetic biocompatible and biodegradable polymers as templates onto which cells are seeded is presented. This report concerns the generation of homogeneous plates of stable mature cartilage in vivo. The delivery of chondrocytes on synthetic polymers configured to provide a large surface area for cell attachment and thus to allow cell function and survival by diffusion of nutrients has resulted in the creation of macroscopic plates of up to 100 mg of new cartilage subcutaneously in 19 of 21 animals. The approximate dimensions and configuration of the original templates were maintained as new cartilage was formed and the polymers resorbed.
Vacanti
C A
CA
Department of Anaesthesiology, Massachusetts General Hospital, Boston.
Langer
R
R
Schloo
B
B
Vacanti
J P
JP
D000818:Animals; D002358:Cartilage, Articular / Q000166:cytology / Q000254:growth & development; D002417:Cattle; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011098:Polyglactin 910; D019736:Prostheses and Implants; D013997:Time Factors
D011098:Polyglactin 910