The sinoatrial ring bundle: a cardiac neural communication system?
The sinoatrial ring bundle (SARB), was originally described as a "whitish bundle of tissue which describes an almost complete loop around the two venae cavae and the coronary sinus" in the adult rabbit heart (Paes de Carvalho et al., 1959). The histologically and electrophysiologically differentiated structure, derived from the embryonic venous valves, was suitably placed for rapid conduction from sinoatrial (SA) to atrioventricular (AV) node, but no evidence was found for this role. Today, the function of the SARB remains obscure. Cholinesterase/silver staining reveals the neural pattern associated with the SARB and suggests a function. Throughout its extent, the SARB contains a bundle of parallel muscle fibers and accompanying long nerves. The nerves distribute to structures at either side of the loop: superolaterally to pectinate muscle and inferomedially to the region of the AV node. Along the curve of the right SARB, the nerves contribute to a dense neural plexus with nerves coiled around muscle. The plexus communicates with the nearby SA node and with the ganglia inferior to the node near the inferior vena cava. The morphological pattern of neural elements is suitably organized to suggest tension monitoring and internodal, neural communication.
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226.
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Roberts
D000818:Animals; D000831:Animals, Newborn; D001283:Atrioventricular Node / Q000033:anatomy & histology; D002802:Cholinesterases / Q000032:analysis; D005260:Female; D005333:Fetus / Q000033:anatomy & histology; D006321:Heart / Q000196:embryology / Q000294:innervation*; D006325:Heart Atria / Q000033:anatomy & histology; D006651:Histocytochemistry; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000201:enzymology; D009431:Neural Conduction; D009474:Neurons / Q000201:enzymology; D011817:Rabbits; D012849:Sinoatrial Node / Q000033:anatomy & histology
D002802:Cholinesterases