[Antioxidant activity of blood serum amd erythrocytes in patients with refractory anemia].
Iron metabolism was studied in patients with refractory anemia. It is shown that continuous transfusions of erythrocytes result in a sharp rise of iron reserves that plays an important role in the development of hemosiderosis. To prevent iron oxidative action it is recommended that the patients should be subjected to therapy with chelating agents and antioxidants simultaneously with transfusions of erythrocytes. A relationship has been noted between blood antioxidant capacity decrease and iron-overloading.
Levina
A A
AA
Andreeva
A P
AP
Tsvetaeva
N V
NV
Tsibul'skaia
M M
MM
Minaeva
L M
LM
Tokarev
Iu N
IuN
D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000097:blood* / Q000628:therapy; D000975:Antioxidants / Q000008:administration & dosage; D001803:Blood Transfusion; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000037:antagonists & inhibitors / Q000097:blood*; D008875:Middle Aged; D010084:Oxidation-Reduction / Q000187:drug effects; D012431:Rutin / Q000008:administration & dosage / Q000097:blood
D000975:Antioxidants; D008315:Malondialdehyde; D012431:Rutin; D007501:Iron
Antioksidantnaia aktivnost' syvorotkii éritrotsitov u bol'nykh refrakternymi anemiiami.