Coronary aneurysms after stent placement: a suggestion of altered vessel wall healing in the presence of anti-inflammatory agents.
Coronary aneurysms are rare after conventional angioplasty and have not been reported after coronary stenting. Coronary artery stent sites were examined by follow-up angiography at a median of 4 months in 29 patients who received the Cook stent (Gianturco-Roubin) for acute coronary closure. Nineteen patients were treated with glucocorticoids administered intravenously or orally, or both, with or without colchicine and results were compared with those in 10 patients who were treated with neither agent. Standard therapy for all patients included routine administration of aspirin and heparin before and warfarin sodium (Coumadin) and aspirin after stent placement. Most patients also received dipyridamole and lovastatin during the follow-up period. Compliance with medications was confirmed by telephone conversation with each patient. Six (32%) of the 19 stented arteries showed evidence of coronary artery aneurysm, defined as expansion of the lumen outside the margins of the stent. None of the patients in the control group (who did not receive steroids or colchicine) developed aneurysm. This pattern of altered vascular healing in stented coronary segments appears to be due to the addition of multiple anti-inflammatory drugs rather than to stent presence alone. This observation demonstrates the possibility of medical impairment of normal vascular remodeling after acute injury and stent placement, which may be of benefit in designing future trials on restenosis.
Andreas Gruentzig Cardiovascular Center, Department of Medicine, Emory University School of Medicine, Emory University Hospital, Atlanta, Georgia 30322.
S T
ST
Rab
S B
SB
King
G S
GS
Roubin
S
S
Carlin
J A
JA
Hearn
J S
JS
Douglas
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D003078:Colchicine / Q000009:adverse effects; D003323:Coronary Aneurysm / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology*; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000187:drug effects* / Q000293:injuries; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000009:adverse effects; D015607:Stents; D014945:Wound Healing / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D003078:Colchicine; D011241:Prednisone; D006854:Hydrocortisone