Transmembrane molecular assemblies regulated by the greater cadherin family.
The cadherin family of cell-cell adhesion molecules is turning out to be much more diverse than previously thought, with members involved in several kinds of intercellular junctions. The adhesive specificity and cytoskeletal interaction of these members varies. Their cytoplasmic terminals are specialized for binding several families of 'mediator' proteins which interconnect to the actin or intermediate filament systems. These multi-molecular complexes have roles not only in cell-cell adhesion, but also in intracellular signalling of developmental information.
National Institute for Medical Research, London, UK.
A I
AI
Magee
R S
RS
Buxton
D000818:Animals; D015820:Cadherins / Q000502:physiology*; D002450:Cell Communication; D002462:Cell Membrane / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D015398:Signal Transduction
D015820:Cadherins; D008565:Membrane Proteins