[Correction for the estimated load of hereditary diseases in the population of the Krasnodarsk district].
Medico-genetical examination of children from 6 invalid houses, 2 asylum houses, 3 internate schools and 1 house for deaf and feeble-hearing children as well as from the internate school for children with poor vision was undertaken in Krasnodar district. 10.6% of the children were found to have chromosomal abnormality, 26.5%--multifactorial pathology and 62.9% of children were affected by monogenic diseases. The spectrum of diseases covers 20 forms, 8 of them being autosomal-dominant, 10--autosomal-recessive and 2--X-linked forms. A "selective" method presented in this article for revealing patients affected by genetical diseases in specialised institutions permitted to evaluate a portion of the patients having been not identified when using the "survey" expeditional method of population--epidemiological study of the district population. This portion constitutes 19%. The more accurate values of genetic load in populations of Krasnodar district were obtained, being 1.06-0.06 for autosomal-dominant, 0.78-0.05 for autosomal-recessive and 0.38-0.05 for X-linked diseases per thousand.
Galkina
V A
VA
Petrin
A N
AN
Golubtsov
V I
VI
D002648:Child; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005799:Genes, Dominant; D005808:Genes, Recessive; D030342:Genetic Diseases, Inborn / Q000453:epidemiology*; D008040:Genetic Linkage; D005828:Genetics, Population; D006801:Humans; D014586:USSR; D014960:X Chromosome
Popravka k otsenke gruza nasledstvennykh bolezneĭ v populiatsii krasnodarskogo kraia.