Inflammatory processes in asthma.
Bronchial inflammation is a characteristic of asthma, but, although postmortem and rare bronchoscopic studies had been performed, it is only after 1980 that many experiments were done. Electron microscopy, immunohistochemistry and molecular biology have enhanced our knowledge. As bronchial biopsies and bronchoalveolar lavage present drawbacks, it is favorable to combine both to obtain the best insights into inflammation. The epithelium is rarely intact in asthmatic patients, the cells being both 'fragile' and activated. Eosinophil inflammation is highly important and likely involved in the damage of the epithelium and submucosa. Airway macrophages and monocytes are present in greater amounts and are activated in the bronchi, and they are certainly involved in the pathogenesis of asthma. Mast cells are activated and some emphasis has been put on lymphocytes. Therefore, asthma appears to be a desquamative bronchitis with mixed cell infiltrate.
Bousquet
J
J
Clinique des Maladies Respiratoires, Hôpital l'Aiguelongue, Montpellier, France.
Chanez
P
P
Campbell
A M
AM
Lacoste
J Y
JY
Poston
R
R
Enander
I
I
Godard
P
P
Michel
F B
FB
D000208:Acute Disease; D001249:Asthma / Q000473:pathology*; D001706:Biopsy; D001980:Bronchi / Q000473:pathology; D001991:Bronchitis / Q000473:pathology*; D002908:Chronic Disease; D006801:Humans; D009092:Mucous Membrane / Q000473:pathology