Relative biological effectiveness for neutron carcinogenesis in monkeys and rats.
The risks of total-body irradiation with large doses of X rays (average dose 6.7 Gy) and fission neutrons (average dose 3.4 Gy) were investigated by keeping a group of long-term surviving monkeys from an experiment on acute effects under continuous observation. On the basis of the number of animals developing tumors in each group as a function of the total observation period and the average absorbed dose, relative biological effectiveness (RBE) values between 4 and 5 have been derived at these high dose levels. In experiments on mammary carcinogenesis in rats the highest RBE values are observed for neutrons with energies of 0.43 to 1 MeV as produced by the p + T reaction or by the fission process. Based upon linear dose-response curves for neutrons and X rays, a maximum RBE value of 15 was observed for induction of adenocarcinomas in WAG/Rij rats. Appreciably higher RBE values would be obtained if the results of the gamma-ray exposure, indicating a nearly quadratic dose-response relationship, were used as a baseline. For radiation protection applications it should be realized, however, that such an increase will be caused by the lower efficiency of low-linear-energy-transfer radiation rather than by an increase in efficiency of the neutron irradiation at low doses.
Institute of Applied Radiobiology and Immunology TNO, Rijswijk, The Netherlands.
J J
JJ
Broerse
D W
DW
van Bekkum
J
J
Zoetelief
C
C
Zurcher
D000230:Adenocarcinoma / Q000209:etiology; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008253:Macaca mulatta; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000209:etiology; D009381:Neoplasms, Radiation-Induced; D009502:Neutrons; D051381:Rats; D012062:Relative Biological Effectiveness