Immuno-enhancing effects of ricin.
The effect of ricin on human peripheral blood mononuclear cells (PBMC) was tested in vitro. At low concentrations (10(-3) and 10(-4) micrograms/ml), ricin potentiated the effect of lipopolysaccharide to induce interleukin 1 (IL-1). Ricin was not mitogenic or co-mitogenic with phytohaemagglutinin or concanavalin A in PBMC cultures at low concentrations (less than 10(-4) micrograms/ml). Higher concentrations of ricin (greater than 10(-3) micrograms/ml) inhibited production of IL-1 by PBMC and the mitogen-driven proliferation of PBMC cultures.
Disease Assessment Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702-5011.
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Krakauer
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D002478:Cells, Cultured; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008070:Lipopolysaccharides; D008213:Lymphocyte Activation / Q000187:drug effects; D012276:Ricin
D000276:Adjuvants, Immunologic; D007375:Interleukin-1; D007376:Interleukin-2; D008070:Lipopolysaccharides; D012276:Ricin