Osteosarcoma of the maxilla. Case report and ultrastructural study.
An osteosarcoma, occurring in the maxillary alveolar ridge of a 17-year-old girl is presented. The tumor consisted predominantly of pleomorphic, mainly osteoblast-like and anaplastic cells. At the ultrastructural level the osteoblast-like cells were characterised by excentrically situated lobed nuclei, extensively swollen, dilated and rough endoplasmic reticulum (RER), polymorphism of mitochondria and sparse Golgi-systems. The undifferentiated cells were characterized by large, electron-lucent nuclei and paucity of non-dilated RER and mitochondria. The intercellular matrix contained collagen fibers with areas of focal collections of calcification.
Abteilung für Zahnärztliche Chirurgie/Oralchirurgie Nord Freie Universität Berlin, Germany.
A A
AA
Langford
H R
HR
Gelderblom
M
M
Unger
P A
PA
Reichart
D008841:Actin Cytoskeleton / Q000648:ultrastructure; D000293:Adolescent; D002467:Cell Nucleus / Q000648:ultrastructure; D002843:Chromatin / Q000648:ultrastructure; D003094:Collagen; D003593:Cytoplasm / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008441:Maxillary Neoplasms / Q000473:pathology / Q000648:ultrastructure*; D008928:Mitochondria / Q000648:ultrastructure; D008938:Mitosis; D009336:Necrosis; D009685:Nuclear Envelope / Q000648:ultrastructure; D010006:Osteoblasts / Q000473:pathology / Q000648:ultrastructure; D012516:Osteosarcoma / Q000473:pathology / Q000648:ultrastructure*
D002843:Chromatin; D003094:Collagen