[The influence of the duration of infusion on the acute toxicity of amphotericin B. Comparison of two hour versus four hour infusions].
A prospective, randomized, double-blind crossover study was performed to compare the incidence and severity of amphotericin-B-induced acute toxicity (chills, fever, nausea and vomiting) after two- and four-hour infusions in 33 leukemic patients with suspected or microbiologically proven systemic fungal infections. Each patient was treated in an alternating fashion of two- and four-hour infusions every other day. Toxicity was graded according to modified WHO-criteria. Evaluation of 264 infusions revealed no difference between the two schedules neither in incidence nor severity of acute toxic reactions. These data indicate that amphotericin B given over 2 hours is equally well--or poorly (!)--tolerated than the four-hour regimen.
Medizinische Klinik und Poliklinik, Universität Düsseldorf.
M
M
Arning
C
C
Aul
B
B
Dresen
W
W
Schneider
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004311:Double-Blind Method; D005334:Fever / Q000139:chemically induced; D006801:Humans; D007262:Infusions, Intravenous; D007938:Leukemia / Q000150:complications*; D008875:Middle Aged; D009181:Mycoses / Q000150:complications / Q000188:drug therapy*; D009325:Nausea / Q000139:chemically induced; D011446:Prospective Studies; D012768:Shivering / Q000187:drug effects; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
D000666:Amphotericin B
Einfluss infusionsdauer auf die Akuttoxizität von Amphotericin B. Vergleich von zwei- versus vierstündigen Infusionen.