Effect of lidocaine on the meninges in an experimental animal model.
Arachnoiditis has been reported in patients who had received previous epidural injections of anesthetic agents. The purpose of this study was to determine if epidural injections of lidocaine are sufficient to cause arachnoiditis. Four monkeys that received a single epidural injection of lidocaine hydrochloride 1% were compared to four controls that had epidural injections of 0.9% saline. Four dogs that had multiple epidural injections of lidocaine hydrochloride 1% were compared to four controls that had multiple injections of saline. All animals were killed on the eighty-fourth day of the experiment. The dural sac, containing nerve roots and spinal cord, was removed intact from the lumbar spinal canal, fixed, sectioned, stained, and examined microscopically for evidence of arachnoid inflammation and fibrosis. No significant changes were found in the treated animals. Lidocaine hydrochloride 1% injected singly or repeatedly in the epidural space does not appear to be a cause of significant chronic meningeal reaction.
Department of Radiology, Medical College of Wisconsin, Milwaukee.
C
C
Nguyen
K C
KC
Ho
V M
VM
Haughton
D000818:Animals; D001099:Arachnoid / Q000187:drug effects / Q000473:pathology; D001100:Arachnoiditis / Q000175:diagnosis; D004285:Dogs; D004388:Dura Mater / Q000187:drug effects / Q000473:pathology; D007268:Injections, Epidural; D008012:Lidocaine / Q000008:administration & dosage / Q000633:toxicity*; D008252:Macaca fascicularis; D008578:Meninges / Q000187:drug effects*; D013355:Subdural Space / Q000187:drug effects / Q000473:pathology
D008012:Lidocaine