Prediction of the cardiac muscle force-velocity relation from its force-time and force-length relations.
The force-velocity relation for cardiac muscle fibers can be calculated from a proposed constitutive law based on force-time and force-length data. The calculated force-velocity relation agrees quite well with the measured force-velocity relation obtained from a quick release of sarcomere controlled rat cardiac trabeculae. The theory confirms the measured linear relationship between maximal velocity of sarcomere shortening and sarcomere length. The implication is that the force-velocity relation is not an independent property, and therefore need not be explicitly included as a rheological element in the constitutive law.
Chadwick
R S
RS
Division of Research Services, National Institutes of Health, Bethesda, MD 20892.
D000818:Animals; D001696:Biomechanical Phenomena; D008433:Mathematics; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D012212:Rheology; D012518:Sarcomeres / Q000502:physiology