Effect of boronic acids on antifreeze proteins.
The activity of antifreeze glycoprotein from the blood serum of Boreagadus saida was strongly inhibited by ions of organic boronic acids as well as by borate. The activity of nonglycoprotein from the blood serum of Pseudopleuronectus americanus, however, was not similarly inhibited. The inhibition by borate is thus specific for molecules with the carbohydrate moiety.
Feeney
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RE
Department of Food Science and Technology, University of California, Davis 95616.
Osuga
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DT
Yeh
Y
Y
D000818:Animals; D021301:Antifreeze Proteins; D001881:Borates / Q000494:pharmacology; D001897:Boronic Acids / Q000378:metabolism / Q000494:pharmacology*; D003903:Deuterium; D005399:Fishes / Q000097:blood*; D005615:Freezing; D005998:Glycine / Q000494:pharmacology; D006023:Glycoproteins / Q000037:antagonists & inhibitors* / Q000097:blood
D021301:Antifreeze Proteins; D001881:Borates; D001897:Boronic Acids; D006023:Glycoproteins; C017562:3-nitrobenzeneboronic acid; C010634:sodium borate; D003903:Deuterium; C010686:benzeneboronic acid; D005998:Glycine