Antiviral activity of polyoxomolybdoeuropate PM-104 against human immunodeficiency virus type 1.
A polyoxomolybdoeuropate PM-104 (NH4)12H2[Eu4(MoO4)(H2O)16(Mo7O24)4].13H2O was found to be a potent inhibitor of the growth of human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS). On the basis of TI50 [median cytotoxic concentration (CC50)/median effective concentration (EC50)], the in vitro anti-HIV-1 activity of PM-104 is favorably comparable to that of a heteropolyoxotungstate PM-19 K7[PTi2W10O40].6H2O, which is one of the most potent HIV-1 inhibitors among the polyoxometalates so far tested. The heteropolyoxomolybdate with a potent anti-HIV-1 activity is introduced for the first time in this communication.
Hiroshima University School of Medicine, Japan.
Y
Y
Inouye
Y
Y
Tokutake
T
T
Yoshida
A
A
Yamamoto
T
T
Yamase
S
S
Nakamura
D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D015497:HIV-1 / Q000187:drug effects*; D009942:Organometallic Compounds / Q000494:pharmacology*
D000998:Antiviral Agents; D009942:Organometallic Compounds; C071498:PM 104