Developmental effects of vitamin B-6 restriction on the locomotor behavior of rats.
The nocturnal spontaneous locomotor behavior of vitamin B-6 restricted and control rats was measured using activity chambers. The results show a generalized hypoactivity in indices of horizontal and vertical activity in neonatal rats fed vitamin B-6 restricted diets during gestation and lactation. This pattern of locomotor behavior changed in the postweaning period to a gradual increase in indices of locomotor activity to a pronounced hyperkinesis in vitamin B-6 restricted young adult rats. This study suggests that long-term vitamin B-6 restriction results in damage and/or abnormal development of neuronal system(s) associated with locomotor behavior.
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205.
T R
TR
Guilarte
R C
RC
Miceli
T H
TH
Moran
D000375:Aging; D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D007774:Lactation; D008297:Male; D008431:Maternal-Fetal Exchange; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011736:Pyridoxine / Q000494:pharmacology; D051381:Rats; D012016:Reference Values; D026681:Vitamin B 6 Deficiency / Q000503:physiopathology*
D011736:Pyridoxine