Accidental overdose of intravenous ofloxacin with benign outcome.
A patient accidentally received approximately 3 g of ofloxacin intravenously. She experienced only moderately severe central nervous system symptoms, which resolved within 9 h. The peak serum ofloxacin level was 39.3 micrograms/ml, approximately seven times the usual peak level. Ofloxacin may possess a considerable safety margin in humans.
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.
R B
RB
Kohler
N
N
Arkins
K J
KJ
Tack
D000328:Adult; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D062787:Drug Overdose / Q000503:physiopathology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D015242:Ofloxacin / Q000008:administration & dosage / Q000506:poisoning* / Q000627:therapeutic use; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy
D015242:Ofloxacin