[Dynamic changes of Ito cells in experimental cirrhosis of rat].
That Ito cells in rat liver express desmin was confirmed by immunohistochemical technique. Anyhow, changes of desmin-positive cells, lysozyme-positive cells and fibronectin were further studied in experimental cirrhosis of rat. It was found that desmin-positive cells, with the transitional features between Ito cells and myofibroblasts or fibroblasts under electron microscope, increased in number and expression of desmin in the necrotic areas as well as in the cellular fibrous septa, but decreased in number in the fibrous septa except those areas close to the edges of the septa. These results suggested that Ito cells, myofibroblasts and fibroblasts may belong to the same cellular system and play an important role in the pathogenesis of cirrhosis. Meanwhile, it was also noted that changes of both fibronectin and lysozyme-positive cells were correlated with those of desmin-positive cells. These provide evidence in vivo that fibronectin and Kupffer cells may exert certain effects on the migration and proliferation of Ito cells in cases of liver cirrhosis.
Department of Pathology, Shanghai Medical University.
J M
JM
Zhao
D000818:Animals; D002251:Carbon Tetrachloride; D003893:Desmin / Q000032:analysis*; D005353:Fibronectins / Q000032:analysis; D007728:Kupffer Cells / Q000473:pathology; D008099:Liver / Q000473:pathology*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009113:Muramidase / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D003893:Desmin; D005353:Fibronectins; D002251:Carbon Tetrachloride; D009113:Muramidase