Study of serum immunoglobulins in normal pregnancy.
Suppression of maternal immune response may be one of the factors contributing to continuation of pregnancy, a state in which the foetus exists as a well tolerated homograft. Studies on serum immunoglobulin levels in pregnancy show varying results. In this study serum immunoglobulin levels of Ig G, Ig A and Ig M were estimated in 75 normal pregnant women, 25 in each trimester. These were compared with a control group of 25 healthy women. A graded significant decrease in Ig G levels was observed throughout the pregnancy. Ig A levels decreased during the first and second trimester of pregnancy. A significant increase in Ig M levels from the first to third trimester was observed.
Department of Physiology, Indira Gandhi Medical College, Nagpur.
M A
MA
Khirwadkar
J R
JR
Kher
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D011247:Pregnancy / Q000276:immunology*; D012016:Reference Values
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins