Probable mechanism of hypoglycemic activity of bassic acid, a natural product isolated from Bumelia sartorum.
Bassic acid, an unsaturated triterpene acid isolated from an ethanol extract of Bumelia sartorum rootbark, elicited significant hypoglycemic activity in alloxan-diabetic rats and altered the pattern of glucose tolerance in these animals. In addition, bassic acid treatment increased significantly the glucose uptake process and glycogen synthesis in isolated rat diaphragm. Bassic acid treatment increased plasma insulin levels significantly in alloxan-diabetic rats. It is suggested that the hypoglycemia activity of bassic acid may be mediated through enhanced secretion of insulin from the pancreatic beta-cells.
Pharmacology and Toxicology Laboratory, Hindustan Antibiotics Limited, Pune, India.
S R
SR
Naik
J M
JM
Barbosa Filho
J N
JN
Dhuley
V
V
Deshmukh
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001938:Brazil; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004837:Epinephrine / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000096:biosynthesis; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000097:blood; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D012132:Respiratory Muscles / Q000187:drug effects / Q000378:metabolism; D014315:Triterpenes / Q000494:pharmacology*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D014315:Triterpenes; C071476:bassic acid; D006003:Glycogen; D005947:Glucose; D004837:Epinephrine