Effects of enzyme supplementation on oral absorption of ciprofloxacin in patients with cystic fibrosis.
The effect of pancreatic enzyme supplementation on the absorption of an oral dose of 250 mg of ciprofloxacin was studied in six patients with cystic fibrosis in a crossover design. The time to achieve maximum serum concentration was slightly reduced upon coadministration of pancreatic enzymes. There were no significant differences in peak concentration, elimination half-life, and area under the concentration-time curve.
Department of Paediatrics, Westmead Hospital, New South Wales, Australia.
G
G
Mack
P J
PJ
Cooper
N
N
Buchanan
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002939:Ciprofloxacin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D010194:Pancreatin / Q000494:pharmacology*; D012140:Respiratory Tract Diseases / Q000188:drug therapy / Q000209:etiology
D002939:Ciprofloxacin; D010194:Pancreatin