Selective IgG2,4 subclass and IgE deficiencies in an adult patient with recurrent pneumonia.
A 28-year-old woman with recurrent pneumonia was found to have selective IgG2, 4 subclass and IgE deficiencies. She had a history of repeated episodes of otitis media and sinusitis in childhood. Her total immunoglobulin level was slightly below the normal range, and selective deficiencies of IgG2, 4 and IgE were found. Although lymphocyte responses to several mitogens were within the normal ranges, peripheral blood mononuclear cells produced only IgM when stimulated by Staphylococcus aureus Cowan 1 and interleukin-2. Gene deletion of the IgG2, 4 subclass was not found, but polymorphism of the IgG gene was detected by DNA analysis of the patient's lymphocytes.
Ninomiya
H
H
First Department of Internal Medicine, School of Medicine, Ehime University, Japan.
Hasegawa
H
H
Fukuoka
T
T
Shiosaka
T
T
Yamauchi
T
T
Saiki
O
O
Fujita
S
S
Kobayashi
Y
Y
D000328:Adult; D001987:Bronchiectasis / Q000209:etiology; D004406:Dysgammaglobulinemia / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D017099:IgG Deficiency; D007073:Immunoglobulin E / Q000172:deficiency*; D011014:Pneumonia / Q000209:etiology*; D012008:Recurrence
D007073:Immunoglobulin E