[The role of bone marrow macrophages in regulating erythropoiesis in different states of the erythron].
Stimulation and inhibition of erythropoiesis were modelled in rats to study the functional condition of central macrophages of the erythroblastic islets (EI) in the bone marrow by determining the total content of lysosomes, pH of lysosomes, activity of acid phosphatase, and 3H-thymidine inclusion in DNA. The properties of the surface charges of the EI cells were judged according to the electrophoretic mobility, the number of acid glycoproteins--according to the staining of the preparations with alcian blue. It is shown that the intensity of erythropoiesis in the EI determines the studied values. Sensitivity of EI macrophages to erythropoietin was demonstrated in EI cultivation.
Zakahrov
Iu M
IuM
Rassokhin
A G
AG
Krest'ianinova
O G
OG
Efimenko
G P
GP
D000740:Anemia / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002056:Burns / Q000097:blood / Q000503:physiopathology; D004900:Erythroblasts / Q000166:cytology* / Q000187:drug effects; D015672:Erythroid Precursor Cells / Q000166:cytology* / Q000187:drug effects; D004920:Erythropoiesis / Q000187:drug effects / Q000502:physiology*; D004921:Erythropoietin / Q000494:pharmacology; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000503:physiopathology; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D010659:Phenylhydrazines; D051381:Rats; D011919:Rats, Inbred Strains
D010659:Phenylhydrazines; C030299:phenylhydrazine; D004921:Erythropoietin
O roli makrofagov kostnogo mozga v reguliatsii éritropoéza pri razlichnykh sostoianiiakh éritrona.