Enhanced exercise-induced rise of aldosterone and vasopressin preceding mountain sickness.
A possible contribution of exercise to the fluid retention associated with acute mountain sickness (AMS) was investigated in 17 mountaineers who underwent an exercise test for 30 min on a bicycle ergometer with a constant work load of 148 +/- 9 (SE) W at low altitude (LA) and with 103 +/- 6 W 4-7 h after arrival at 4,559 m or high altitude (HA). Mean heart rates during exercise at both altitudes and during active ascent to HA were similar. Exercise-induced changes at LA did not differ significantly between the eight subjects who stayed well and the nine subjects who developed AMS during a 3-day sojourn at 4,559 m. At HA, O2 saturation before (71 +/- 2 vs. 83 +/- 2%, P less than 0.01) and during exercise (67 +/- 2 vs. 72 +/- 1%, P less than 0.025) was lower and exercise-induced increase of plasma aldosterone (617 +/- 116 vs. 233 +/- 42 pmol/l, P less than 0.025) and plasma antidiuretic hormone (23.8 +/- 14.4 vs. 3.4 +/- 1.8 pmol/l, P less than 0.05) was greater in the AMS group, whereas exercise-induced rise of plasma atrial natriuretic factor and changes of hematocrit, potassium, and osmolality in plasma were similar in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Medicine, Medizinische Poliklinik Inselspital, Bern, Switzerland.
P
P
Bärtsch
M
M
Maggiorini
W
W
Schobersberger
S
S
Shaw
W
W
Rascher
J
J
Girard
P
P
Weidmann
O
O
Oelz
D000064:Acclimatization / Q000502:physiology; D000082:Acetaminophen / Q000627:therapeutic use; D000328:Adult; D000375:Aging / Q000502:physiology; D000450:Aldosterone / Q000097:blood*; D000532:Altitude Sickness / Q000097:blood* / Q000188:drug therapy / Q000652:urine; D001798:Blood Proteins / Q000378:metabolism; D015444:Exercise; D005080:Exercise Test; D006339:Heart Rate / Q000502:physiology; D006400:Hematocrit; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009051:Mountaineering; D010101:Oxygen Consumption; D011654:Pulmonary Edema / Q000503:physiopathology; D014563:Urodynamics / Q000502:physiology; D014667:Vasopressins / Q000097:blood*; D014882:Water-Electrolyte Balance / Q000502:physiology
D001798:Blood Proteins; D006728:Hormones; D014667:Vasopressins; D000082:Acetaminophen; D000450:Aldosterone