Acquired immunity to systemic candidiasis in immunodeficient mice.
Twenty-seven percent of beige-athymic (bg/bg nu/nu) mice died of systemic candidiasis 7-20 weeks after gastrointestinal tract colonization with Candida albicans. Conversely, beige-euthymic (bg/bg nu/+) mice colonized with C. albicans for a similar time period did not die or develop systemic candidiasis. C. albicans-colonized bg/bg nu/+ mice, but not bg/bg nu/nu mice, developed C. albicans-specific T cell-dependent antibody- and cell-mediated immune responses, indicating that T cell-dependent responses might explain the acquired resistance of bg/bg nu/+ mice to systemic candidiasis. Colonization with C. albicans enhanced the resistance of T cell-competent bg/bg nu/+ mice, but not bg/bg nu/nu mice, to systemic candidiasis. T cell-mediated immunity activated after mucosal colonization with C. albicans plays an important role in resistance to systemic candidiasis.
Department of Surgery, University of Wisconsin Medical School, Madison 53706-1532.
M T
MT
Cantorna
E
E
Balish
D000818:Animals; D000908:Antibodies, Fungal / Q000097:blood; D015153:Blotting, Western; D001921:Brain / Q000382:microbiology; D002176:Candida albicans / Q000276:immunology / Q000302:isolation & purification; D002177:Candidiasis / Q000276:immunology*; D004198:Disease Susceptibility; D005856:Germ-Free Life; D007110:Immunity, Active; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D051379:Mice; D008819:Mice, Nude; D013154:Spleen / Q000382:microbiology
D000908:Antibodies, Fungal