Genetic variation within and between lines of diabetes-prone and non-diabetes-prone BB rats; allele distribution of 8 protein markers.
Twenty-four inbred and 2 outbred lines of the BB rat have been genetically characterized by establishing the allele distribution of 8 monogenic protein markers. The marker genes are: plasma alkaline phosphatase-1 (Alp-1), catalase-1 (Cs-1), carboxylesterases (Es-1, Es-2, Es-14), glyoxalase I (Glo-1), group specific component (Gc), and haemoglobin-beta-chain (Hbb). At least 3 linkage groups are represented by this set of markers. Genetic variation was found both within and between lines. Within-line variation was observed in 4 lines, including the 2 outbred lines. The other 22 lines could be subdivided into 4 groups, each representing a unique allele distribution pattern.
Department of Laboratory Animal Science, State University, Utrecht, The Netherlands.
J B
JB
Prins
L
L
Herberg
M
M
Den Bieman
L F
LF
van Zutphen
D000483:Alleles; D000818:Animals; D001798:Blood Proteins / Q000235:genetics*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D004198:Disease Susceptibility; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D008297:Male; D051381:Rats; D011913:Rats, Inbred BB / Q000235:genetics*
D001798:Blood Proteins; D005819:Genetic Markers