The effect of subchronic administration of vigabatrin on learning and memory in nonepileptic rats.
The present experiments investigated whether subchronic administration of vigabatrin, a GABA-mimetic drug, affects the performance of normal rats in the behavioural tasks assessing learning and memory. The effects of vigabatrin [50-200 mg/kg (IP)/day] administration on the acquisition and retention of water maze and passive avoidance task were studied. According to the results of three experiments, vigabatrin treatment did not markedly impair the acquisition or retention of water maze task. Furthermore, vigabatrin-treated rats were not inferior to saline-treated rats in reversal learning of water maze task. On the other hand, vigabatrin treatment slightly increased the speed of swimming in rats. The administration of vigabatrin did not affect the performance (training latency, number of training trials, testing latency) of rats in the passive avoidance task. According to these results, the effects of vigabatrin, a new antiepileptic drug, on the performance of nonepileptic rats were modest in behavioural tasks used to assess learning and memory.
Department of Neurology, University of Kuopio, Finland.
J
J
Sirviö
A
A
Ylinen
H
H
Lahtinen
A
A
Ronkainen
P
P
Riekkinen
T
T
Halonen
P J
PJ
Riekkinen
D000596:Amino Acids / Q000378:metabolism; D000614:Aminocaproates / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004827:Epilepsy / Q000523:psychology; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D020888:Vigabatrin
D000596:Amino Acids; D000614:Aminocaproates; D000927:Anticonvulsants; D020888:Vigabatrin