Identification of CTX-2, a novel cefotaximase from a Salmonella mbandaka isolate.
A strain of Salmonella mbandaka isolated from the feces of an Algerian infant showed a reduced susceptibility to cefotaxime (MIC, 8 mg/liter). This strain produced two transferable beta-lactamases of pIs 5.3 and 5.6. The novel beta-lactamase with a pI of 5.3 inhibited by clavulanic acid showed cefotaxime hydrolysis and was therefore designated CTX-2.
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Laboratoire de Bactériologie, Faculté de Médecine, Clermont-Ferrand, France.
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Labia
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D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000032:analysis; D004587:Electrophoresis, Agar Gel; D004926:Escherichia coli / Q000201:enzymology; D005243:Feces / Q000382:microbiology; D006801:Humans; D007223:Infant; D007525:Isoelectric Focusing; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D012475:Salmonella / Q000201:enzymology*; D001618:beta-Lactamases / Q000032:analysis* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; C071167:beta-lactamase CTX-2; D001618:beta-Lactamases