[The effects of verapamil on calcium and magnesium concentrations during intestinal shock in rats].
In rats with shock induced by superior mesenteric artery occlusion (SMAO), the concentration of calcium in liver cell mitochondria increased and that of magnesium decreased. In the same period, the calcium concentration in the homogenate of liver, lung, and kidney also decreased. 5mg/kg verapamil, which was given subcutaneously one hour before SMAO, could reversed the above calcium concentrations that the calcium concentration in liver cell mitochondria decreased and that in the homogenate of liver, lung, and kidney increased. We described the mechanism and clinical implications of the changes of calcium and magnesium concentrations during shock of SMAO, and the possibility of treatment with verapamil.
117 th Hospital, People's Liberation Army.
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Dong
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012769:Shock / Q000188:drug therapy / Q000378:metabolism*; D014700:Verapamil / Q000627:therapeutic use*
D014700:Verapamil; D008274:Magnesium; D002118:Calcium