[Climacteric syndrome: comparison of several secondary therapies].
During a first one year period a random treatment for climacteric symptoms with "Estriol vaginal cream" vs "Trazodone and Estriol vaginal cream" and, after it and only in patients not complaining of dyspareunia, with "Trazodone" vs "Veralipride" has been conducted. After the first year all women complaining of dyspareunia were treated with Estriol vaginal cream. Eighty women were enrolled in the five treatment groups. After three months of treatment, a good remission of symptoms was shown, with differences in relations to treatment schedules. Dyspareunia subsided for more than 70% in women treated with Estriol vaginal cream (either by itself or in association), and Estriol vaginal cream achieved the best response from the highest number of the considered symptoms, besides being the only active treatment in insomnia. A good answer on hot flushes and "irritability, anxiety, depression" was obtained by Trazodone, while Veralipride showed to be more active on all neurovegetative symptoms (hot flushes, sweatings, tinglings, palpitations, astenia).
Cattedra di Patologia Ostetrica Ginecologica, Università delgi Studi di Milano.
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Bianco
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Colombo
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Tassan Simonat
D000328:Adult; D002979:Climacteric / Q000187:drug effects*; D004359:Drug Therapy, Combination; D004414:Dyspareunia / Q000188:drug therapy; D004964:Estriol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D013469:Sulpiride / Q000031:analogs & derivatives / Q000627:therapeutic use; D013577:Syndrome; D014196:Trazodone / Q000008:administration & dosage / Q000627:therapeutic use; D014622:Vaginal Creams, Foams, and Jellies
D014622:Vaginal Creams, Foams, and Jellies; D013469:Sulpiride; D004964:Estriol; C027429:veralipride; D014196:Trazodone
La sindrome climaterica: confronto tra alcune terapie secondarie.