Case report: adult T-cell leukemia/lymphoma associated with recurrent strongyloides hyperinfection.
Adult T-cell leukemia/lymphoma (ATLL) was demonstrated postmortem in a 47-year-old woman initially manifesting severe hypercalcemia and a vertebral compression fracture. Hyperinfection with Strongyloides stercoralis preceded the appearance of ATLL by several months and ultimately dominated the terminal course. Although HTLV-I and S. stercoralis commonly infect the same host, only three other cases of concomitant ATLL and hyperinfection have been reported in English. The apparent rarity of this association suggests that immunologic sequelae of ATLL do not predispose to dissemination and multiplication of Strongyloides. Observations pertinent to this conclusion are reviewed.
Phelps
K R
KR
Department of Medicine, State University of New York Health Science Center, Brooklyn.
Ginsberg
S S
SS
Cunningham
A W
AW
Tschachler
E
E
Dosik
H
H
D000818:Animals; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000737:chemistry; D006801:Humans; D015458:Leukemia, T-Cell / Q000150:complications* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D012008:Recurrence; D013321:Strongyloides; D013322:Strongyloidiasis / Q000150:complications* / Q000473:pathology
D004279:DNA, Viral