[Comparative studies of in-vivo and in-vitro contraction behavior of gallbladders with impaired function].
The contractility of human gallbladders without calculi of 10 patients with typical biliary pain was investigated in vivo (n = 7; pharmacosonography) and in vitro (n = 10; isometric registration). In 6 out of 7 cases, investigated in vivo as well as in vitro, the contractility was identical--therefore the smooth-muscle-preparation in the organ-bath could be an interesting model for studies with CCK-antagonists. 3 of the in-vitro-preparations showed hypomotility consecutive to acetylcholine- and CCK-stimulation. Histologically, the destruction of the normal gallbladder wall structure by scars, chronic inflammation and the evidence of so-called Rokitansky-Aschoff-sinuses could be proved. The importance of these findings probably causal to the process of cholelithogenesis is discussed.
Medizinisch-Poliklinisches Institut, Universität Leipzig.
M
M
Gottschalk
J
J
Bauer
B
B
Wohlgemuth
R
R
Rogos
D000109:Acetylcholine / Q000494:pharmacology; D000328:Adult; D000368:Aged; D002766:Cholecystokinin / Q000494:pharmacology; D005260:Female; D005704:Gallbladder / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D005705:Gallbladder Diseases / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000503:physiopathology
D002766:Cholecystokinin; D000109:Acetylcholine
Vergleichende Untersuchungen des Kontraktionsverhaltens funktionsgestörter Gallenblasen in vivo und in vitro.