Plasma protein binding of nitroxynil in several species.
The binding of nitroxynil to total plasma proteins of cows, sheep and rabbits was characterized using equilibrium dialysis. The data indicate clearly that nitroxynil was highly (97-98%) bound to plasma protein of each animal. This linear binding would be due to the particular power exerted by serum albumin. The results are in good agreement with known pharmacokinetic properties of nitroxynil in domestic species.
Laboratoire de Pharmacologie-Toxicologie, INRA, Toulouse, France.
M
M
Alvinerie
R
R
Floc'h
P
P
Galtier
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002417:Cattle / Q000097:blood*; D005260:Female; D009611:Nitroxinil / Q000378:metabolism* / Q000493:pharmacokinetics; D011485:Protein Binding; D011817:Rabbits / Q000097:blood*; D012756:Sheep / Q000097:blood*
D001798:Blood Proteins; D009611:Nitroxinil