[Nonspecific mitogenic factors of Mycoplasma: immunobiological properties].
The readily extractable surface membrane proteins of M. arthritidis and sodium dodecyl sulfate-solubilized membrane components of M. fermentans were found to have the highest mitogenic action on the splenocytes from CBA mice and the least on those from C57BL/6 mice. The M. arthritidis mitogen (MAM) is an antigen-dependent T-cell mitogen that inhibits the specific proliferation of T cells, inducing their non-specific proliferation. Dextran sulfate-induced blockage of lymphocyte proliferation under the action of MAM was stimulated with interleukin-2, which suggests MAM-induced expression of receptors to interleukin-2 onto the surface of lymphocytes. A factor that has the activity of interleukin-1 and stimulates the proliferation of C57BL/6 murine thymocytes with phytohemagglutinin was found to liberate into a culture medium.
Pronin
A V
AV
Gorina
L G
LG
D000818:Animals; D000941:Antigens; D000942:Antigens, Bacterial; D003470:Culture Media; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000502:physiology; D007376:Interleukin-2 / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008934:Mitogens / Q000502:physiology*; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D011506:Proteins; D018089:Superantigens; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology
D000941:Antigens; D000942:Antigens, Bacterial; D003470:Culture Media; D007375:Interleukin-1; D007376:Interleukin-2; D008934:Mitogens; C052996:Mycoplasma arthritidis mitogen; D011506:Proteins; D018089:Superantigens
Nespetsificheskie mitogennye faktory mikoplazm: immuno- biologicheskie svoĭstva.