Treatment of painful diabetic neuropathy with capsaicin 0.075%.
An 8-week, double-blind, vehicle-controlled study was conducted to determine the effectiveness of topical capsaicin 0.075% cream in relieving pain associated with diabetic neuropathy. Patients were selected who experienced moderate to very severe pain, which interfered with sleep or activities on a daily basis, and who were unresponsive or intolerant to conventional therapy. The results after 8 weeks showed a statistically significant difference in favor of the capsaicin-treated patients, with 90% of these patients improved. The results of this study indicate that topical capsaicin 0.075% cream is safe and effective in managing painful diabetic neuropathy.
American Center for Foot Health Research, Baltimore, MD 21227.
N M
NM
Scheffler
P L
PL
Sheitel
M N
MN
Lipton
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002211:Capsaicin / Q000008:administration & dosage / Q000627:therapeutic use*; D003929:Diabetic Neuropathies / Q000150:complications* / Q000175:diagnosis; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement
D002211:Capsaicin