Extracellular matrix regulation of growth factor and protease activity.
Extracellular matrices bind many growth factors, proteases, and protease inhibitors. These interactions not only localize these molecules to the pericellular environment, but also modulate their biological activities. Recent evidence suggests that some growth factors may be active in vivo primarily in complexes with extracellular matrix molecules and that this interaction may be essential to their activity.
New York University Medical Center, New York.
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Flaumenhaft
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Rifkin
D000818:Animals; D010450:Endopeptidases / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans
D006133:Growth Substances; D010450:Endopeptidases