[Inter- and intra-individual variability of pharmacokinetic parameters for contraceptive steroids].
Serum levels of ethinylestradiol (E2) and levonorgestrel (LNG) have been determined in 10 volunteers of similar age after administration of 1 tablet of the oral contraceptives Gravistat and Ediwal, respectively, each containing 0.05 mg E2 and 0.125 mg LNG, using a cross over design. The studies were carried out at intervals of 4 weeks, within the follicular phase of the menstrual cycle and under standardized conditions. Wide variations were observed between the women in the calculated pharmacokinetic parameters, while there was a relatively close correspondence between the intra-individually obtained values, except for one case.
Carol
W
W
Klinik für Frauenheilkunde und Geburtshilfe, Friedrich-Schiller-Universität Jena.
Klinger
G
G
Jäger
R
R
Kasch
R
R
Michels
W
W
D000328:Adult; D003278:Contraceptives, Oral, Hormonal / Q000493:pharmacokinetics*; D003280:Contraceptives, Oral, Synthetic / Q000493:pharmacokinetics*; D004997:Ethinyl Estradiol / Q000097:blood / Q000493:pharmacokinetics*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D009644:Norgestrel / Q000097:blood / Q000493:pharmacokinetics*; D011863:Radioimmunoassay
D003278:Contraceptives, Oral, Hormonal; D003280:Contraceptives, Oral, Synthetic; D009644:Norgestrel; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination
Untersuchungen zur inter- und intraindividuellen Variabilität pharmako-kinetischer Parameter für kontrazeptive Steroide.