[Systemic proliferative angioendotheliomatosis: a cutaneous manifestation of malignant B-cell lymphomas. Histologic and immunohistologic studies of two cases].
Angioendotheliomatosis proliferans systemisata (AEPS) is a rare disease entity characterized by a predominantly intravascular proliferation of tumour cells. Two forms of AEPS are differentiated: a very rare, benign and self-limiting form, which is endothelial in origin, and a more common, malignant form, which is an angiotropic intravascular malignant B-cell lymphoma. Histological and immunohistological investigations of the malignant form of AEPS are presented: In a 69-year-old woman cutaneous lesions appeared 5 months before the diagnosis of B-immunoblastic lymphoma. In a 57-year-old woman lesions were observed simultaneously with the relapse of a high-grade malignant B-cell lymphoma. Immunohistological identification of the proliferating cell type made diagnosis of intravascular B-cell lymphoma possible in paraffin-embedded biopsies.
Dermatohistologisches Labor der Gemeinschaftspraxis, Friedrichshafen.
H
H
Kutzner
W
W
Englert
D
D
Hellenbroich
G
G
Embacher
U
U
Kutzner
J
J
Schröder
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006390:Hemangioendothelioma / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D016393:Lymphoma, B-Cell / Q000473:pathology*; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000473:pathology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D014062:Tongue Neoplasms / Q000473:pathology
D014408:Biomarkers, Tumor
Angioendotheliomatosis proliferans systemisata: eine kutane Manifestation maligner B-Zellen-Lymphome. Histologische und immunhistologische Untersuchungen an zwei Fällen.