[The protective action of vasocyclin (prostacyclin) on the ischemic myocardium].
The effect of vasocyclin (prostacyclin) on the blood supply, activity and functional state of the intact and ischemic myocardium was studied in experiments on anesthetized cats. The drug (100, 300 and 500 mg/kg/min) was shown to produce a dose-dependent increase of the coronary blood flow, systolic and cardiac outputs, an enhancement of the myocardial contractile function, a lowering of arterial blood pressure. Under acute occlusion of the coronary artery vasocyclin improves the functional state of the myocardial ischemic focus, stabilizes the contractile and pumping functions of the heart, exerts the antiarrhythmic action.
Kazanova
G V
GV
Tsorin
I B
IB
Chirkova
E Iu
EIu
Chichkanov
G G
GG
D000818:Animals; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D011464:Epoprostenol / Q000494:pharmacology / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D013997:Time Factors
D011464:Epoprostenol
Zashchitnoe deĭstvie vazotsiklina (prostatsiklina) na ishemizirovannyĭ miokard.