Influence of cefpodoxime on selected immunological functions and bacterial pathogenicity factors in vitro.
The influence of a new oral cephalosporin cefpodoxime, on several interactions of the host-parasite relationship was investigated. Pretreatment of polymorphonuclear granulocytes (PNG) with cefpodoxime at therapeutical dosage in vitro did not have a significant effect on chemotaxis and luminol-dependent chemiluminescence. On the other hand, human serum did not exert a considerable effect on the bactericidal activity of cefpodoxime on Klebsiella pneumoniae and Staph. aureus. Serum resistance of Klebsiella pneumoniae was not altered after pretreatment with cefpodoxime 1/16 MIC (0.03 micrograms/ml) for 3 to 27 hours.
Department of Medical Microbiology, University of Kiel.
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Schubert
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Ullmann
D000666:Amphotericin B / Q000494:pharmacology; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006790:Host-Parasite Interactions / Q000187:drug effects*; D066298:In Vitro Techniques; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000472:pathogenicity; D008163:Luminescent Measurements; D008165:Luminol; D009504:Neutrophils / Q000187:drug effects; D010088:Oxidoreductases; D010587:Phagocytosis; D015610:Serum Bactericidal Test; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity; D000097623:Cefpodoxime
D000666:Amphotericin B; D015296:Ceftizoxime; D008165:Luminol; D010088:Oxidoreductases; D000097623:Cefpodoxime