[The angioprotector and hypolipemic activity of leukomizin in experimental atherosclerosis].
A sesquiterpenic lactone leucomyzin possessing the anti-inflammatory activity significantly reduces the extensiveness of atherosclerotic lesions of the aortas of the rabbits receiving dietary cholesterol. The drug prevents an increase of permeability of the aorta and microvessels under the influence of cholesterol, bradykinin, ovalbumin and histamine. In addition to the angioprotective action, leucomyzin possesses the hypolipidemic activity in rats with experimental hyperlipidemias and (after prolonged administration) in rabbits with cholesterol atherosclerosis. By its antiatherosclerotic and angioprotective activity leucomyzin is superior to prodectine, by its hypolipidemic action it is comparable with miscleron.
Kirmukov
A G
AG
Aĭzikov
M I
MI
Rasulova
S A
SA
Sidiakin
G P
GP
Sham'ianov
I D
ID
Malikov
V M
VM
D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism; D002994:Clofibrate / Q000627:therapeutic use; D004036:Diet, Atherogenic; D004353:Drug Evaluation, Preclinical; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D015939:Kitasamycin / Q000627:therapeutic use*; D007783:Lactones / Q000627:therapeutic use*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011092:Polyethylene Glycols; D011727:Pyridinolcarbamate / Q000627:therapeutic use; D051381:Rats; D012717:Sesquiterpenes / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D012717:Sesquiterpenes; D015939:Kitasamycin; D011092:Polyethylene Glycols; D011727:Pyridinolcarbamate; D002994:Clofibrate; C016811:tyloxapol
Angioprotektornaia i gipolipidemicheskaia aktivnost' leukomizina pri éksperimental'nom ateroskleroze.