HLA and T cell receptor polymorphisms in pauciarticular-onset juvenile rheumatoid arthritis.
The immunogenetic basis of pauciarticular-onset juvenile rheumatoid arthritis is unclear. We therefore analyzed the HLA and T cell receptor genes present in a clinically well-defined group of patients. We found that the DR8 haplotype contributes most of the HLA-associated risk, although alleles at other loci contribute independently. A candidate disease-associated T cell receptor polymorphism, in contrast, was not identified in this population. Mechanistic implications of these findings are discussed.
Immunology Program, Virginia Mason Research Center, Seattle, WA 98101.
B S
BS
Nepom
U
U
Malhotra
D A
DA
Schwarz
J W
JW
Nettles
J G
JG
Schaller
P
P
Concannon
D001171:Arthritis, Juvenile / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics*; D008040:Genetic Linkage; D006684:HLA-DR Antigens / Q000235:genetics; D059810:HLA-DR Serological Subtypes; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C041559:HLA-DR8 antigen; D011948:Receptors, Antigen, T-Cell