Involvement of sapecin in embryonic cell proliferation of Sarcophaga peregrina (flesh fly).
Addition of antibodies against sapecin to the culture medium of NIH-Sape-4 cells derived from a Sarcophaga embryo greatly inhibited cell proliferation, whereas addition of sapecin stimulated cell proliferation. These results suggest that sapecin is involved in the proliferation of embryonic cells of Sarcophaga. Sapecin is known to have potent antibacterial activity, so it seems to have two different biological functions: i.e. protection against bacterial infection and stimulation of embryonic cell proliferation.
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
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D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004175:Diptera / Q000196:embryology*; D004625:Embryo, Nonmammalian; D007074:Immunoglobulin G; D007301:Insect Hormones / Q000276:immunology / Q000494:pharmacology*; D019476:Insect Proteins; D007700:Kinetics
D007074:Immunoglobulin G; D007301:Insect Hormones; D019476:Insect Proteins; C057638:sapecin protein, Sarcophaga; C042572:sarcotoxin I protein, Sarcophaga peregrina