Antimalarial activity and cytotoxicity of Evodia fatraina stem bark extracts.
Stem bark extracts of Evodia fatraina (Rutaceae) were tested for antimalarial activity in vitro on Plasmodium falciparum using an isotopic semi-microtest and in vivo on Plasmodium berghei in mice. Ethyl acetate extract showed moderate antimalarial activity in vitro (IC50 = 8.5 micrograms ml-1). However, ethanolic extract exhibited significant potency in vivo (65% suppression of parasitaemia). Moreover, low toxicity against HeLa cells and L 929 fibroblasts was observed with ethanolic extract (IC50 = 95 micrograms ml-1 and 60 micrograms ml-1, respectively).
Institut Malgache de Recherches Appliquées, Antananarivo, Madagascar.
S
S
Ratsimamanga-Urverg
P
P
Rasoanaivo
A
A
Rakoto-Ratsimamanga
J
J
Le Bras
O
O
Ramiliarisoa
J
J
Savel
J P
JP
Coulaud
D000284:Administration, Oral; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D010962:Plasmodium berghei / Q000187:drug effects*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D010936:Plant Extracts