Tumor necrosis factor-beta specifically inhibits the activity of preoptic warm-sensitive neurons in tissue slices.
Effects of human tumor necrosis factor-beta (TNF-beta) were studied on the single neural activities of the preoptic thermosensitive and thermally insensitive neurons in tissue slices of rats. Physiological doses (0.7-40 ng/ml) of TNF-beta decreased the firing rate in most of the warm-sensitive neurons, but showed no marked tendency in the response patterns of thermally insensitive neurons. The actions of TNF-beta on warm-sensitive neurons were blocked by concurrent application of sodium salicylate. The results suggest that the intracranial TNF may produce fever through local production of prostaglandins.
Department of Physiology, Saga Medical School, Japan.
T
T
Nakashima
T
T
Kiyohara
T
T
Hori
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D002118:Calcium / Q000494:pharmacology; D066298:In Vitro Techniques; D008233:Lymphotoxin-alpha / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011301:Preoptic Area / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012980:Sodium Salicylate / Q000494:pharmacology
D008233:Lymphotoxin-alpha; D008274:Magnesium; D002118:Calcium; D012980:Sodium Salicylate