Possible involvement of 1,2-diacetylbenzene in diethylbenzene-induced neuropathy in rats.
The role of 1,2-diacetylbenzene (1,2-DAB) in the peripheral nerve toxicity of 1,2-diethylbenzene (1,2-DEB) was investigated in rats. Gas chromatography-mass spectrometry identified 1,2-DAB in the urine samples of rats given 165 mg kg-1 1,2-DEB orally on four consecutive days. 1,2-DAB shared not only the ability of 1,2-DEB to cause bluish discoloration of skin, internal organs and urine, but unlike 1,2-DEB it turned hair blue at the site of intraperitoneal injection. Intraperitoneal administration of 10 mg kg-1 and 20 mg kg-1 1,2-DAB to groups of 12 rats, 4 days a week for 11 and 6 weeks, caused a dose- and time-dependent decrease in mean sensory and motor conduction velocities. Recovery in a 5-week post-exposure period was gradual but consistent. The effect of 1,2-DAB on the amplitude of the sensory action potential was ambiguous. The findings support the hypothesis that the formation of 1,2-diacetylbenzene derivatives contributes to the neurotoxicity of 1,2-DEB.
Institut National de Recherche et de Sécurité, Vandoeuvre, France.
F
F
Gagnaire
A
A
Ensminger
B
B
Marignac
J
J
De Ceaurriz
D000098:Acetophenones / Q000633:toxicity* / Q000652:urine; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001555:Benzene Derivatives / Q000633:toxicity* / Q000652:urine; D004558:Electric Stimulation; D008401:Gas Chromatography-Mass Spectrometry; D007274:Injections, Intraperitoneal; D008297:Male; D009046:Motor Neurons / Q000187:drug effects; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D009431:Neural Conduction / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000098:Acetophenones; D001555:Benzene Derivatives; C064750:1,2-diethylbenzene; C048792:1,2-diacetylbenzene