The effect of acutely administered beta-casomorphin derivatives on pentylenetetrazol-kindled mice.
Some of the Tyr-containing and desTyr beta-casomorphin derivatives were tested for their anticonvulsant action in pentylenetatrazol-kindled mice. It was demonstrated that some of these substances exert powerful action against kindled seizures, suggesting therapeutical usefulness.
Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, Germany.
A
A
Becker
G
G
Grecksch
H
H
Matthies
D000595:Amino Acid Sequence; D000818:Animals; D000927:Anticonvulsants; D004723:Endorphins / Q000008:administration & dosage* / Q000737:chemistry; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000737:chemistry; D012640:Seizures / Q000517:prevention & control
D000927:Anticonvulsants; D004723:Endorphins; D010446:Peptide Fragments; C021968:beta-casomorphins; C059556:beta-casomorphin, des-Tyr-; D010433:Pentylenetetrazole