Detection of focal infection by 111In-human polyclonal IgG.
Eleven patients with suspected foci of inflammation and/or infection were scanned with 111In-labeled polyclonal human IgG. Seven patients were suspected of having the source of their infection in the abdomen, three in the musculoskeletal system and one in the thoracic aorta. The test was truly positive in seven patients, truly negative in three and falsely negative in one. All the true positive cases showed abnormally increased radiopharmaceutical uptake at the site of infection by six hours, suggesting the diagnosis, although the intensity of uptake increased progressively 24 hours later. There were no untoward effects noted in this series. This examination is potentially useful in the early depiction of focal sources of infection/inflammation.
Tumeh
S S
SS
Department of Radiology, Brigham & Women's Hospital, Boston, Massachusetts 02115.
Carvalho
P A
PA
van den Abbeele
A D
AD
Maguire
J H
JH
Rauh
D A
DA
Neptune
M
M
Kassis
A I
AI
D000038:Abscess / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002429:Cecal Diseases / Q000000981:diagnostic imaging; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D004716:Endometritis / Q000000981:diagnostic imaging*; D005260:Female; D005490:Focal Infection / Q000000981:diagnostic imaging*; D006801:Humans; D007074:Immunoglobulin G; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011877:Radionuclide Imaging
C069971:DTPA-IgG complex; D007074:Immunoglobulin G; D007205:Indium Radioisotopes; D004369:Pentetic Acid