Evaluation of DNA damage induced by norfloxacin in liver and kidney of adult rats and in fetal tissues after transplacental exposure.
Norfloxacin, a recently developed antimicrobial fluoroquinolone, was investigated for DNA-damaging activity in rat liver and kidney. After oral administration of single doses ranging from 1 to 8 mmole/kg, DNA fragmentation was absent in liver and kidney both 2 and 6 h after treatment. However, when administered to pregnant rats, the highest doses produced a detectable amount of DNA damage in fetal tissues. This damage appears to be an aspecific consequence of maternal and fetal toxicity rather than a specific genotoxic effect.
Pino
A
A
Institute of Pharmacology, University of Genoa, Italy.
Maura
A
A
Villa
F
F
Masciangelo
L
L
D000818:Animals; D004249:DNA Damage; D005260:Female; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008431:Maternal-Fetal Exchange; D009643:Norfloxacin / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D009643:Norfloxacin