[Does glycemic level influence the pharmacokinetics of an antibiotic (cefoperazone)?].
Hyperglycemia may modify pharmacokinetics of some antibiotics as shown in the literature. We studied the influence of glycaemic levels on pharmacokinetics properties of cefoperazone in 12 type 1 insulin dependent diabetic patients. Hyperglycaemia was obtained by a reduction of one quarter of their usual insulin dosage and normoglycaemia by an artificial pancreas (Biostator GCIIS). Cefoperazone had a high protein affinity and a high biliary elimination. Pharmacokinetic study was performed during a 8 hour period following one gram intravenous bolus. We did not found any influence of glycaemic level (normoglycaemia or hyperglycaemia) on the pharmacokinetic parameters of cefoperazone.
Clinique Médicale et des Maladies Infectieuses, Hôpital Pellegrin, Bordeaux, France.
H
H
Gin
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F
Demotes-Mainard
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S
Magimel
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H
Albin
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P
Morlat
J
J
Aubertin
D001786:Blood Glucose / Q000502:physiology*; D002438:Cefoperazone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology*; D007275:Injections, Intravenous; D007332:Insulin Infusion Systems; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D002438:Cefoperazone
Existe-t-il une influence du niveau glycémique sur la pharmacocinétique d'un antibiotique (la céforpérazone)?