[Contribution to the pharmacodynamic study of a ketosulphoxide derivative (omega-methylsulphinyl alpha-acetothiophene). Activity on the CNS].
In order to establish the pharmacological profile of a series of ketosulphoxide derivatives which have been synthesized in the pharmaceutic and organic chemistry department of the Sevilla Pharmacy Faculty, a study of omega-methylsulphinyl alpha-acetothiophene has been initiated. Experiments were carried out on male Swiss mice, using a dosage of 100 and 200 mg/kg. High toxicity tests have been undertaken, followed by an investigation of activity at CNS levels. The results obtained show that the composite mentioned has a marked depressant activity lacking in any significant toxic effects.
Laboratorio de Farmacognosia y Farmacodinamia, Facultad da Farmacia, Universidad de Sevilla, Espagne.
M V
MV
Toro
E
E
Marhuenda
J A
JA
Lopez
I
I
Fernandez
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
Contribution à l'étude pharmacodynamique d'un dérivé cétosulfoxyde (omega-méthylsulfinyl alpha-acétothiophène). Action sur le SNC.