Dimethyl-beta-propiothetin, new potent resistive-agent against stress-induced gastric ulcers in rats.
The preventive effect of dimethyl-beta-propiothetin (DMPT) and methylmethionine at 5 mM each on stress-induced gastric ulcers in rats was compared. Gastric ulcer-diseased rats were induced by the water immersion method. The ulcer index of test rats in the DMPT group was noticeably lower, compared with those in the methylmethionine and the control groups. A comparison of the activities of serum transaminases and amylase, and the amounts of various blood components in test rats claimed that the DMPT group rats were most resistive to such strain compared with the control and the methylmethionine group rats. These results indicate that DMPT is a potent preventive-agent against the stress-induced gastric ulcers in rats without any side effects.
Laboratory of Biochemistry, College of Nutrition, Koshien University, Hyogo, Japan.
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Nakajima
D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001774:Blood Chemical Analysis; D007101:Immersion; D008297:Male; D008715:Methionine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications*; D013452:Sulfonium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D013452:Sulfonium Compounds; D008715:Methionine; C038344:methionine methyl ester; C068078:dimethylpropiothetin