A study relating to bioavailability and renal elimination of bismuth after oral administration of basic bismuth nitrate.
The extent to which bismuth is absorbed following single and multiple oral administration of basic bismuth nitrate was investigated in healthy male subjects. The blood concentration of bismuth and the amounts excreted in urine and feces were determined. The results show that only a small fraction of the administered bismuth dose given in this form is absorbed. Existing differences in the absorption kinetics between this relatively insoluble bismuth salt and colloidal bismuth citrate are discussed.
Temmler Pharma GmbH, Marburg, Germany.
W A
WA
Behrendt
C
C
Gröger
D
D
Kuhn
H U
HU
Schulz
P
P
Topfmeier
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D001729:Bismuth / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D004334:Drug Administration Schedule; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D009566:Nitrates / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D013607:Tablets
D005765:Gastrointestinal Agents; D009566:Nitrates; D013607:Tablets; C065545:bismuth nitrate; D001729:Bismuth