[Various genetic models in Crohn disease].
Crohn's disease has a genetic predisposition. In the light of epidemiological data, especially the type of familial clustering, simple modes of inheritance can be excluded. At the first glance, our results implied a polygenic multifactorial basis. Further processing of our data by the "mixed model" of Morton revealed a higher probability for a recessive gene with low penetrance. However, the differences in fit between the various models are relatively slight. Also considering ascertainment problems, a definite decision concerning an appropriate model must be deferred until sure genetic markers have been identified. Nevertheless, only a certain number of manifestations may be ascribed to a genetic predisposition, others have to be catagorized as phenocopies.
Abteilung f. Gastroenterologie, Heinrich-Heine-Universität Düsseldorf.
J
J
Purrmann
S
S
Cleveland
K J
KJ
Hengels
D000293:Adolescent; D000328:Adult; D003424:Crohn Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005799:Genes, Dominant / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D012307:Risk Factors
D005819:Genetic Markers
Untersuchungen zu verschiedenen Vererbungsmodellen beim Morbus Crohn.