[Changes of the urinary excretions of hydroxyproline and fibronectin fragment in acute pancreatitis].
Urinary excretions of hydroxyproline and fibronectin fragment (FN fragment) were serially investigated in the patients with acute pancreatitis or acute exacerbation of chronic pancreatitis. While urinary excretion of FN fragment showed the maximal level on the first day of admission, high levels of urinary hydroxyproline were observed on the second to fifth day. As to the changes in the individuals, peak level of urinary FN fragment always preceded that of hydroxyproline. And it was assumed that the elevation of FN fragment excretion on the early phase of pancreatitis reflected tissue damages of pancreas itself and complicated organs, and following elevation of hydroxyproline showed enhanced collagen metabolism induced by acute inflammation and tissue damage. According to the severity of pancreatitis, urinary excretion of FN fragment on the first day increased, and it was therefore suggested that urinary FN fragment would be one of the parameters for the assessment of the severity of acute pancreatitis.
Second Department of Internal Medicine, Showa University School of Medicine.
N
N
Takayama
M
M
Ogawa
I
I
Nakano
H
H
Funatomi
Y
Y
Hatta
D000208:Acute Disease; D002908:Chronic Disease; D005353:Fibronectins / Q000652:urine*; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D010195:Pancreatitis / Q000652:urine*; D010446:Peptide Fragments / Q000652:urine*
D005353:Fibronectins; D010446:Peptide Fragments; D006909:Hydroxyproline