Persistence of HIV-1 silent infection in seronegative subjects at high risk.
Twenty regular sexual partners of HIV-1 infected subjects, without detectable human immunodeficiency virus (HIV-1) antibody and positive for HIV-1 genome by in situ hybridization (ISH), were selected and studied longitudinally for 6-36 months to estimate the duration of silent infection. During the follow-up period, 10 showed atypical Western Blot (WB) patterns. Two seronegative partners seroconverted. Rapid progress to AIDS was observed in 7 seropositive subjects.
Institute of Infectious Diseases, Policlinico Umberto I, University of Rome, La Sapienza, Italy.
M
M
Pezzella
M A
MA
Rosci
M
M
Miceli
N
N
Vonesch
E
E
Sturchio
M
M
Mirolo
E
E
Mannella
D000328:Adult; D015153:Blotting, Western; D002353:Carrier State / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000276:immunology*; D006679:HIV Seropositivity; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D012307:Risk Factors; D012747:Sexual Partners