Enhanced haloperidol-induced prolactin stimulation with chronic neuroleptic treatment in the rat.
Animals were treated either acutely, or chronically for 21 days, with a low dose (0.1 mg/kg) of haloperidol, then sacrificed to obtain trunk blood for radioimmunoassay of prolactin (PRL) level. PRL concentrations on day 21 of chronic treatment were greater than two-fold those produced by acute neuroleptic. Challenge with apomorphine to rats withdrawn for 48 hours revealed similar PRL reductions as a group withdrawn from chronic vehicle injections.
Lynch
M R
MR
Research Service, Veterans Administration Medical Center, Syracuse, New York 13210.
Woo
J
J
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D011388:Prolactin; D006220:Haloperidol; D001058:Apomorphine