[Cognitive evoked potentials at the stages II and III of human immunodeficiency virus infection].
Neuropsychological and psychometric investigations have sometimes attested to and sometimes denied the existence of cognitive perturbations during the early phases of human immunodeficiency virus (HIV) infection (stages II and III of the CDC classification): strictly asymptomatic seropositivity or generalized lymphadenopathy. Therein lies the basis of the debate concerning the neurotropism of the virus and its deleterious effects on the central nervous system (CNS). We hoped to contribute to the resolution of this discussion by recording late evoked auditory potentials, which are composed of two types of components: exogenous responses attesting to the reception of stimuli by specific sensory areas of the CNS, regardless of their informative value for the subject; and endogenous responses that occur later, appearing when the subject is required to distinguish between different stimuli, for example, counting high-pitched sounds randomly distributed among low-pitched ones. The latter responses, which have been most extensively studied for wave P300, are associated with cognitive functions, and alterations of the evoked cognitive potentials have been observed during the course of demential syndromes of various origins. Fifteen individuals were subjected to the protocol for recording long-latency, evoked auditory potentials. These studies were completed by a battery of psychometric tests, two methods for evaluating depression and an assessment of the anxiety level. The results showed a significant lengthening of the latency of wave P300 in the seropositive subjects. This prolongation also affected one of the exogenous components, i.e., wave P2. In addition, their intelligence quotients, regardless of whether the IQ explores the so-called crystallized component or the fluid component of intelligence, were not significantly different from those of the general population.(ABSTRACT TRUNCATED AT 250 WORDS)
Gil
R
R
Service de Neurologie, CHU La Milétrie, Poitiers.
Breux
J P
JP
Neau
J P
JP
Becq-Giraudon
B
B
Pinon
M L
ML
Preud'homme
J L
JL
Jonveaux
T
T
Cazenave-Roblot
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000503:physiopathology*; D000328:Adult; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D005260:Female; D006679:HIV Seropositivity / Q000503:physiopathology; D006801:Humans; D008297:Male
Potentiels évoqués cognitifs aux stades II et III de l'infection par le virus de l'immunodéficience humaine.