A comparison between intubation and food addition as routes of oral exposure for northern bobwhites to DDT insecticide.
Our objective was to compare two methods of oral dosing of p,p'-DDT (1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane) on uptake of DDT metabolites and isomers (i.e., p,p'-DDT, o,p'-DDT, p,p'-DDE, o,p'-DDE, p,p'-DDD, o,p'-DDD) in livers and brains. p,p'-DDT was administered to northern bobwhite (Colinus virginianus) by intubation with corn oil or as a feed additive for 56 days. When adjusted for amount of DDT consumed, total DDT (sigma DDT, the summation of all DDT metabolites and isomers) and p,p'-DDE concentrations differed significantly (P less than 0.10) in both brains and livers, whereas p,p'-DDD differed only in brains and p,p'-DDT differed only in livers. Paired comparisons between brains and livers differed significantly for sigma DDT, (P less than 0.05), p,p'-DDE (P less than 0.05) and p,p'-DDT (P less than 0.1) for both intubated and food-dosed treatment groups, whereas p,p'-DDD (P less than 0.05) differed only in the intubated group. We concluded that method of oral exposure affected the uptake of DDT in livers and brains for northern bobwhites.
Sullivan
J P
JP
Department of Fisheries and Wildlife Sciences, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Scanlon
P F
PF
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000378:metabolism; D003088:Colinus / Q000378:metabolism*; D003314:Corn Oil; D003634:DDT / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D004435:Eating; D005260:Female; D007441:Intubation, Gastrointestinal / Q000662:veterinary; D016018:Least-Squares Analysis; D008099:Liver / Q000378:metabolism; D011897:Random Allocation
D003314:Corn Oil; D003634:DDT