A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics.
A new antibiotic, okicenone was isolated from the culture broth of Streptomyces sp. KO-3599. The antibiotic possesses cytocidal activity against mammalian tumor cells in vitro at concentrations of 0.53-11.0 micrograms/ml whereas the antibiotic showed no antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1,000 micrograms/ml.
Komiyama
K
K
Kitasato Institute, Tokyo, Japan.
Funayama
S
S
Anraku
Y
Y
Ishibashi
M
M
Takahashi
Y
Y
Kawakami
T
T
Omura
S
S
D000818:Animals; D000873:Anthracenes / Q000302:isolation & purification / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000627:therapeutic use; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000873:Anthracenes; D000903:Antibiotics, Antineoplastic; C071011:okicenone