Changes in plasma lipoprotein metabolism in chicks in response to polychlorinated biphenyls (PCBs).
The results of the present study strongly suggest that the hypertriglyceridaemia in chicks treated with Aroclor 1254 is a result of reduction in VLDL clearance rather than an increase in rate of VLDL secretion. The decrease in post-heparin LPL activity responsible for reduced VLDL clearance may be mediated by cytokines produced by chronic activation of the immune system.
AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian, U.K.
H
H
Griffin
D
D
Windsor
J
J
Brolakoglu
D020155:3-Hydroxybutyric Acid; D000818:Animals; D001140:Aroclors / Q000633:toxicity; D002645:Chickens; D020111:Chlorodiphenyl (54% Chlorine); D006207:Half-Life; D006885:Hydroxybutyrates / Q000097:blood; D015228:Hypertriglyceridemia / Q000139:chemically induced; D008071:Lipoprotein Lipase / Q000097:blood; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000097:blood; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D014280:Triglycerides / Q000097:blood
D001140:Aroclors; D006885:Hydroxybutyrates; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D020111:Chlorodiphenyl (54% Chlorine); D011078:Polychlorinated Biphenyls; D008071:Lipoprotein Lipase; D020155:3-Hydroxybutyric Acid