Is there a role for vitamin D in osteoporosis?
Vitamin D has certain clearly defined effects on bone: vitamin D deficiency results in defective bone mineralization, whereas 1,25-dihydroxy-vitamin D3 (1,25-(OH)2D3) stimulates bone resorption. Studies of the use of 1,25-(OH)2D3 to prevent or treat osteoporosis have given conflicting results concerning bone remodeling. However, 1,25-(OH)2D3 or other vitamin D metabolites seem to play a role in the correction of calcium malabsorption, which is a common feature in osteoporosis.
Lamberg-Allardt
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Endocrine Research Laboratory, University of Helsinki, Minerva Foundation Institute for Medical Research, Finland.
D000818:Animals; D001862:Bone Resorption / Q000209:etiology; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D014807:Vitamin D / Q000494:pharmacology / Q000502:physiology*
D014807:Vitamin D