[Combination therapy in chronic heart failure. Hemodynamic effects with a calcium antagonist-diuretic combination].
In twelve patients with chronic cardiac insufficiency (NYHA II-III), the effect of a fixed combination of drugs (160 mg verapamil/50 mg triamterene/25 mg hydrochlorothiazide) on cardiac hemodynamics was studied over a period of four weeks. During the course of treatment, the arterial blood pressure decreased from 145 +/- 16/93 +/- 9 mmHg to 133 +/- 18/86 +/- 14 mmHg, and the heart rate from 79 +/- 13 to 75 +/- 12 beats/min. Exercise blood pressure (900 watts) decreased from 180 +/- 22/104 +/- 14 mmHg to 158 +/- 25/96 +/- 17 mmHg and the heart rate from 104 +/- 14 to 100 +/- 16 beats per min. After treatment, a decrease in pulmonary arterial pressure and resting pulmonary capillary wedge pressure (PPA:-2.3 mmHg, PPC:-1.4 mmHg) and in exercise pressure (PPA:-8.5 mmHg, PPC:-6.6 mmHg) was established. Clinically relevant changes in cardiac output and cardiac index were not observed. The subjective symptoms (NYHA stage) were improved in eight patients. Combination treatment would appear suitable for patients with mild-to-moderate cardiac insufficiency.
Podszus
T h
Th
Abteilung Poliklinik, Universität Marburg/Lahn.
Peter
J H
JH
Völger
K D
KD
Zilles
P
P
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004338:Drug Combinations; D006333:Heart Failure / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006976:Hypertension, Pulmonary / Q000188:drug therapy; D008875:Middle Aged; D014223:Triamterene / Q000008:administration & dosage*; D014700:Verapamil / Q000008:administration & dosage*
D004338:Drug Combinations; D006852:Hydrochlorothiazide; D014700:Verapamil; D014223:Triamterene
Kombinationstherapie bei chronischer Herzinsuffizienz. Hämodynamische Wirkungen unter einer Kalziumantagonist-Diuretikum-Kombination.