Effects of lonidamine on the membrane electrical properties of Ehrlich ascites tumor cells.
The effects of lonidamine on membrane electrical properties of Ehrlich ascites tumor cells are investigated. Using a dielectric relaxation technique based on the Maxwell-Wagner effect and elaborated by a 'single-shell' fitting procedure, the data indicate that both membrane conductivity and membrane permittivity increase after treatment of these cells with lonidamine while the conductivity of the cytosol remains unchanged. Changes in membrane proteins and/or lipids are suggested which lead to altered membrane structure and/or function.
Laboratorio di Ultrastrutture, Istituto Superiore di Sanità, Roma, Italy.
M T
MT
Santini
C
C
Cametti
P L
PL
Indovina
W
W
Malorni
M
M
Benassi
F P
FP
Gentile
S
S
Castiglione
A
A
Floridi
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D003600:Cytosol / Q000187:drug effects; D004553:Electric Conductivity / Q000187:drug effects; D007191:Indazoles / Q000494:pharmacology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects*; D051379:Mice; D013535:Suspensions; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007191:Indazoles; D013535:Suspensions; C016371:lonidamine