Microbial models of mammalian metabolism: fungal metabolism of the diterpene sclareol by Cunninghamella species.
Microbial metabolism of the diterpene sclareol was studied. Screening studies have shown a number of microorganisms capable of metabolizing sclareol. Preparative scale fermentation with Cunninghamella species NRRL 5695 has resulted in the production of two fungal metabolites that have been characterized as 3 beta-hydroxysclareol and 18-hydroxy-sclareol with the use of 2D nmr techniques. The yield of the two metabolites was improved by utilizing resting-cell suspensions of Cunninghamella species NRRL 5695.
Department of Pharmacognosy, School of Pharmacy, University of Mississippi University 38677.
S A
SA
Kouzi
J D
JD
McChesney
D000818:Animals; D004224:Diterpenes / Q000378:metabolism*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008322:Mammals / Q000378:metabolism*; D008954:Models, Biological; D015394:Molecular Structure; D009090:Mucorales / Q000378:metabolism*
D004224:Diterpenes; C070762:3-hydroxysclareol; C070761:18-hydroxysclareol; C070760:sclareol