Aluminium mobilization following renal transplantation and the possible effect on susceptibility to bacterial sepsis.
We monitored urinary aluminium excretion in 60 renal allograft recipients for the first 6 months following transplantation. Plasma and urinary aluminium values steadily decreased during the study period. Patients who suffered two or more bacterial infections during this period excreted more urinary aluminium than those with only one or no infections. Twenty patients experienced a two-fold or greater sudden unexpected increase in urinary aluminium excretion: 14 of these patients (60 per cent) had evidence of infection (10 bacterial and four viral), at this time. Both urinary aluminium and fractional aluminium excretion were greater in the 10 patients with bacterial infection than in the other 10 patients. Thus, patients who suffered bacterial infections had higher base-line urinary aluminium excretion, suggesting a higher body burden of aluminium. In addition, bacterial sepsis was associated with aluminium release from tissue stores with an associated increase in urinary aluminium excretion. This implies that patients with an increased body burden of aluminium are more prone to bacterial sepsis, and that aluminium excretion is increased during sepsis.
Davenport
A
A
Department of Renal Medicine, St James's University Hospital, Leeds.
Davison
A M
AM
Will
E J
EJ
Newton
K E
KE
Toothill
C
C
D000328:Adult; D000368:Aged; D000535:Aluminum / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001424:Bacterial Infections / Q000378:metabolism*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000378:metabolism*; D011184:Postoperative Period; D011446:Prospective Studies
D000535:Aluminum