The effects of fibronectin on the adherence of bacteria to corneal epithelium.
The aim of our experiments was to determine whether treatment with topical fibronectin led to increased adherence of Staphylococcus aureus or Pseudomonas aeruginosa to rabbit corneas with epithelial defects. No significant effect of fibronectin was demonstrated. For all strains of S. aureus tested, the number of recoverable organisms was decreased at 24 h compared to 1 h. None of the rabbits developed infectious keratitis.
Houston Veterans Administration Medical Center, Texas.
A Y
AY
Matoba
R J
RJ
Hamill
M S
MS
Osato
D000287:Administration, Topical; D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects*; D015169:Colony Count, Microbial; D003315:Cornea / Q000502:physiology*; D004848:Epithelium / Q000502:physiology; D005353:Fibronectins / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000502:physiology*; D011817:Rabbits; D013211:Staphylococcus aureus / Q000502:physiology*
D005353:Fibronectins