Preparation, characterization, and antitumor activity of water-soluble aminoalkanol platinum(II) complexes.
A new series of highly water-soluble aminoalkanol platinum(II) complexes have been synthesized and characterized by elemental analysis, conductance, IR, and 195Pt NMR. Preliminary in vitro and in vivo screening tests for antitumor activities of these complexes against L1210 murine leukemia were performed. In general, these compounds were far less cytotoxic than cisplatin and possessed only a moderate degree of antitumor activity.
Department of Medical Oncology, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
A R
AR
Khokhar
Q Y
QY
Xu
R A
RA
Newman
Z H
ZH
Siddik
D000818:Animals; D000970:Antineoplastic Agents; D002945:Cisplatin / Q000494:pharmacology / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D012995:Solubility; D014867:Water
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D014867:Water; D002945:Cisplatin