Lipid A and related compounds. XXVI. Syntheses of biologically active penta-O-acetyl-N-glycoloylneuraminyl- and penta-O-acetyl-3-deoxy-D-galacto-2- nonulopyranosonic acid-(alpha 2----6)-D-glucosamine-4-phosphate analogs of lipid A.
The syntheses of novel penta-O-acetyl-N-glycoloylneuraminyl- and penta-O-acetyl-3-deoxy-D-glycero-D-galacto-2-nonulopyranosonic acid-(alpha 2----6)-D-glucosamine-4-phosphate analogues of lipid A containing sialic acid in place of 3-deoxy-D-manno-2-octulosonic acid are described. Preliminary examination of the biological activity revealed that two synthetic disaccharides showed mitogenic activities and weak antitumor activities.
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
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Ikeda
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Kawai
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Achiwa
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D008050:Lipid A / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008934:Mitogens / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D008050:Lipid A; D008934:Mitogens