[Further advances in the salt sensitivity hypothesis in man].
The hypothesis, proposed by us since 1981, that genetically determined salt sensitivity exists in the normotensive population has been confirmed by other groups. We propose that in salt sensitive subjects an augmented upregulation of alpha-2 combined with simultaneous downregulation of beta-2 adrenoceptors by a high salt diet (resulting in an increase in the "operative" adrenoceptor ratio) is responsible for the rise of blood pressure. In salt resistant subjects the "operative alpha-2/beta-2 adrenoceptor ratio" does not increase on a high salt intake. The adrenoceptor changes in salt sensitive subjects probably lead to an increased central sympathetic outflow (through receptor changes in certain brain areas) and to simultaneous enhanced end-organ response in resistance vessels and in the kidney, causing enhanced vasoconstriction and enhanced sodium reabsorption. Long term follow up of salt sensitive normotensives will show, whether they develop "essential hypertension" in the future.
Abteilung für Innere Medizin, Krankenhaus Barmherzige Brüder, Universität Graz.
F
F
Skrabal
P
P
Kotanko
P
P
Wach
T
T
Kenner
A
A
Lueger
H
H
Raid
E
E
Rieger
D000042:Absorption; D001794:Blood Pressure / Q000187:drug effects; D004198:Disease Susceptibility; D006801:Humans; D011941:Receptors, Adrenergic / Q000187:drug effects*; D012964:Sodium / Q000378:metabolism; D012982:Sodium, Dietary / Q000009:adverse effects*; D014661:Vasoconstriction / Q000187:drug effects
D011941:Receptors, Adrenergic; D012982:Sodium, Dietary; D012964:Sodium
Weitere Fortschritte bei der Salzsensitivitätshypothese beim Menschen.