Platelet activating factor antagonists. Structure of N,N'-bis(3,4,5-trimethoxybenzoyl)-2-piperazinylmethyl 2,2-dimethylpropanoate.
Racemic title compound, C30H40N2O10, Mr = 588.65, triclinic, P1-, a = 10.154 (7), b = 11.820 (9), c = 15.038 (8) A, alpha = 96.02 (5), beta = 1.07.54 (4), and gamma = 110.34 (5) degrees, V = 1569 (2) A3, Z = 2, Dx = 1.25 g cm-3, Cu K alpha, lambda = 1.5418 A, mu = 7.4 cm-1, F(000) = 628, T = 293 K, R = 0.0470, wR = 0.0481 for 1961 unique observed reflections. The piperazine ring adopts a chair conformation and the molecule shows limited flexibility of the pseudo-twofold-related trimethoxybenzoyl moieties. The planes through the piperazine and the two trimethoxyphenyl rings are oriented almost perpendicular to each other. Apart from a few possible weak hydrogen bonds, the molecules are held together by weak pi overlap and van der Waals forces.
Department of Structural Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
J B
JB
Stensland
J P
JP
Batt
A
A
Lamouri
J J
JJ
Godfroid
D008968:Molecular Conformation; D015394:Molecular Structure; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D014961:X-Ray Diffraction
D010879:Piperazines; D010972:Platelet Activating Factor; C071630:N,N'-bis(3,4,5-trimethoxylbenzoyl)-2-piperizinylmethyl 2,2-dimethylpropanoate