[Prosthesis infections: is ambulatory conservative therapy possible?].
Infections associated with prosthetic devices involve an increased risk of persistence or relapse if the foreign body is not removed. Clinical and experimental observations indicate a lack of correlation between the minimal bactericidal concentration of a drug and its efficacy in device-related infections. Alternative in-vitro tests indicate that the efficacy of a drug experimental implant-associated infections depends on its activity on non-growing and adhering microorganisms. These data have been evaluated in a clinical pilot study. 12 patients with orthopedic device-related infections were treated with rifampin-containing regimens because this drug has excellent activity on adherent microorganisms. The success rate was 83% during a follow-up period of 2 years or until the removal of the device. Nevertheless, before considering conservative treatment of device-related infections, controlled clinical studies are needed which confirm the experimental results.
Departement für Innere Medizin, Universitätskliniken, Kantonsspital Basel.
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Zimmerli
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Widmer
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D006168:Guinea Pigs; D006801:Humans; D007769:Lactams; D019736:Prostheses and Implants; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000601:surgery; D012293:Rifampin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D007769:Lactams; D012293:Rifampin
Protheseninfektion: Ist eine ambulante konservative Therapie möglich?