A potential weak allelic difference in male-specific antigen between two inbred strains of mice.
Differences were detected between male-specific antigen(s) from BALB/c and C57BL/10 mice. Reciprocal crosses between these strains were analysed by means of a popliteal lymph node assay enumerating cells secreting IgM and IgG in a T-dependent bystander B-cell response. The responses, while being indirect, weak and variable, suggested that there are differences in 'immunogenicity' coded by Y-linked (male-specific) genes. This conclusion was strengthened by the results of experiments carried out in Y-backcross mice, where spleen cells from male C57BL mice with a BALB/c-Y (B10.C-YC) stimulated low popliteal lymph node responses in female littermates in comparison with C57BL mice with their own Y-chromosome. In contradistinction, male spleen cells from a BALB/c with a C57B1/10-Y chromosome (C.B10-YB), injected into a hind footpad of a female littermate, induced a relatively higher popliteal lymph node response.
Dresser
D W
DW
National Institute for Medical Research, London, UK.
D000483:Alleles; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003433:Crosses, Genetic; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006087:Graft vs Host Reaction / Q000276:immunology; D006182:H-Y Antigen / Q000235:genetics* / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011110:Polymorphism, Genetic; D013154:Spleen / Q000276:immunology
D006182:H-Y Antigen; D007074:Immunoglobulin G; D007075:Immunoglobulin M