Disturbances in myocardial creatine kinase following ethanol administration to rats--trials of prevention by allopurinol, desferrioxamine and propranolol.
A significant decrease in myocardial creatine kinase (CK) activity is apparent 2 hr after an acute ethanol load (2.3 g/kg, i.p.) in the rat. A lower dose (1.15 g/kg, i.p.), as well as ethanol addition in vitro up to 50 mM, do not affect this activity. Pretreatment with allopurinol (146 mumols/kg, i.p.) given at 16 hr and at 30 min before ethanol (2.3 g/kg) or with desferrioxamine (152 mumols/kg, i.p.) 30 min before ethanol failed to prevent the ethanol-induced decrease in CK activity. By contrast, propranolol (17 mumols/kg, i.p.), administered 30 min before ethanol elicited an enhanced CK activity in both control and ethanol-treated rats. This finding is likely related to the beta-blocking action and/or antioxidant properties of propranolol. Chronic ethanol intake (18% in calories) for 4 weeks also induced a decrease in myocardial CK activity, which could play a role in the pathogenesis of alcoholic cardiomyopathy.
Hininger
I
I
Department of Biomedical Research on Alcoholism, Université René Descartes, Paris, France.
Ribiere
C
C
Nordmann
R
R
D000428:Alcohol Drinking / Q000503:physiopathology*; D000435:Alcoholic Intoxication / Q000201:enzymology*; D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism*; D003676:Deferoxamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000493:pharmacokinetics; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D009206:Myocardium / Q000201:enzymology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D000493:Allopurinol; D011433:Propranolol; D003402:Creatine Kinase; D003676:Deferoxamine