Nucleolar organizer regions (NORs) in dysplastic and neoplastic epithelial lesions of the conjunctiva.
Using a silver staining technique (AgNOR technique), we have investigated the nucleolar organizer-associated proteins (NORs) in formalin-fixed paraffin embedded conjunctival specimens of 15 intraepithelial squamous carcinomas, 10 hyperplastic-dysplastic samples and 10 control epithelial fragments; the mean number of intranuclear black dots was determined for each case. A significant difference in the mean number of NORs was found when intraepithelial squamous carcinomas were compared with hyperplastic-dysplastic lesions (P less than 0.001); in addition, normal control conjunctiva and hyperplastic-dysplastic lesions were also discernible (P less than 0.05).
Dipartimento di Patologia Umana, Policlinico Uuniversitario G. Martino di Messina, Italy.
M
M
Muscarà
G
G
Giuffré
C J
CJ
Trombetta
F
F
Bisantis
G
G
Tuccari
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D003228:Conjunctiva / Q000473:pathology; D005134:Eye Neoplasms / Q000235:genetics / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000473:pathology*; D016622:Silver Staining