Antibacterial effectiveness of ciprofloxacin 0.3% ophthalmic solution in the treatment of bacterial conjunctivitis.
Two hundred eighty-eight cases of culture-proven bacterial conjunctivities were evaluated as part of two multicentered, randomized, prospective clinical studies comparing the antibacterial efficacy of topically administered ciprofloxacin 0.3% either with a placebo or with tobramycin 0.3%. In the first study, ciprofloxacin was significantly (P less than .001) more effective than the placebo. It eradicated or reduced the various bacterial pathogens in 93.6% of patients, compared to 59.5% for the placebo. In the second study, ciprofloxacin (94.5%) and tobramycin (91.9%) were equally effective. Topically applied ciprofloxacin eradicated or reduced all isolated bacterial species, attesting to its broad antibacterial spectrum and its potential usefulness in treating external ocular infections.
Leibowitz
H M
HM
Department of Ophthalmology, Boston University School of Medicine, Massachusetts 02118.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy*; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D003231:Conjunctivitis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D009883:Ophthalmic Solutions; D011446:Prospective Studies; D014031:Tobramycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions; D002939:Ciprofloxacin; D014031:Tobramycin