A linear-quadratic model of cell survival considering both sublethal and potentially lethal radiation damage.
We assessed the dose-dependence of repair of potentially lethal damage in Chinese hamster ovary cells x-irradiated in vitro. The recovery ratio (RR) by which survival (SF) of the irradiated cells was enhanced increased exponentially with a linear and a quadratic component, namely xi and psi: RR = e xi D + psi D2. Survival of irradiated cells can thus be expressed by a combined linear-quadratic model considering four variable, namely alpha and beta for the capacity of the cells to accumulate sublethal damage, and xi and psi for their capacity to repair potentially lethal damage: SF = e(xi - alpha)D + (psi - beta)D2.
Rutz
H P
HP
Laboratoire de Radiobiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Coucke
P A
PA
Mirimanoff
R O
RO
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D002588:Cesium Radioisotopes; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005260:Female; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D016014:Linear Models; D010053:Ovary / Q000166:cytology / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental
D002588:Cesium Radioisotopes