Pyridinium crosslinks as markers of bone resorption in patients with breast cancer.
Collagen breakdown, and thus bone resorption, can now be assessed by measuring the urinary excretion of the collagen crosslinks, pyridinoline (Pyd) and deoxypyridinoline (Dpd). In a pilot study we measured Pyd and Dpd in 20 patients with breast cancer, ten with known bone metastases and ten with no recognised metastases in bone or elsewhere after 1 year's subsequent follow up. Eight out of the ten patients with metastases had crosslink excretion values higher than the reference interval, but so did some patients without known metastatic disease. For both crosslinks there was a clear correlation with serum alkaline phosphatase activity measured at about the same time. We consider that measurement of urinary collagen crosslink assays may have a place in the early detection of metastatic spread to bone.
Department of Biochemical Medicine, University of Dundee, UK.
C R
CR
Paterson
S P
SP
Robins
J M
JM
Horobin
P E
PE
Preece
A
A
Cuschieri
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000378:metabolism* / Q000652:urine; D015415:Biomarkers / Q000652:urine; D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000652:urine; D001862:Bone Resorption / Q000378:metabolism* / Q000652:urine; D001943:Breast Neoplasms / Q000378:metabolism* / Q000556:secondary / Q000652:urine; D002118:Calcium / Q000652:urine; D003094:Collagen / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011726:Pyridinium Compounds / Q000032:analysis
D000596:Amino Acids; D015415:Biomarkers; D003432:Cross-Linking Reagents; D011726:Pyridinium Compounds; C015484:pyridinoline; C036020:deoxypyridinoline; D003094:Collagen; D002118:Calcium