Drug treatment of experimental Capillaria hepatica infection in mice.
This report presents the results obtained using 14 anthelmintic compounds that were tested in experimental white mice of the Swiss-Webster strain for their action against Capilaria hepatica. Four of the drugs effectively prevented deposition of C. hepatica ova in mouse liver. The doses at which these four drugs prevented greater than 99% of egg deposition were: albendazole, 30 mg/kg; febantel, 30 mg/kg; mebendazole, 3.13 mg/kg; and oxfendazole, 12.5 mg/kg. Of these, mebendazole is the only agent for which the application of five daily doses of 3.13 mg/kg lay within the dose range recommended for man.
Department of Zoology, University of Witwatersrand, Johannesburg, South Africa.
R F
RF
Cheetham
M B
MB
Markus
D015766:Albendazole / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use; D002195:Capillaria / Q000187:drug effects*; D006146:Guanidines / Q000494:pharmacology / Q000627:therapeutic use; D008099:Liver / Q000469:parasitology; D008297:Male; D008463:Mebendazole / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy*; D010063:Ovum / Q000187:drug effects
D000871:Anthelmintics; D001562:Benzimidazoles; D006146:Guanidines; D008463:Mebendazole; D015766:Albendazole; C011030:oxfendazole; C017309:febantel