Increases of neuron-specific enolase, S-100 protein, creatine kinase and creatine kinase BB isoenzyme in CSF following intraventricular catheter implantation.
In 15 patients without acute brain injury the concentrations of Neuron-specific Enolase (NSE), S-100 Protein (S-100), Creatine Kinase (CK), and Creatine Kinase BB isoenzyme (CK-BB) in ventricular cerebrospinal fluid (CSF) were measured immediately after lateral ventricle cannulation for diagnostic or treatment purposes. From patients who were treated with a shunt another CSF sample was obtained one week after shunt implantation by puncture of the antechamber of the valve. The CSF concentrations of NSE, S-100, CK and CK-BB after cannulation were found to be of the same order as found in patients with severe head injury, stroke or subarachnoid haemorrhage. One week after shunt implantation the concentrations of S-100, CK and CK-BB had returned to normal levels in almost all patients, while the NSE concentrations remained elevated. These findings indicate that the sampling procedure may result in contamination of CSF with NSE, S-100, CK and CK-BB and they should be taken into account in the prognostic evaluation of enzyme concentrations after brain injury.
Department of Neurosurgery, Glostrup County Hospital, Copenhagen, Denmark.
A
A
Kruse
K G
KG
Cesarini
F W
FW
Bach
L
L
Persson
D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000201:enzymology; D001930:Brain Injuries / Q000201:enzymology / Q000601:surgery*; D002557:Cerebrospinal Fluid Shunts; D003402:Creatine Kinase / Q000134:cerebrospinal fluid*; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000201:enzymology / Q000601:surgery; D007527:Isoenzymes; D010537:Peritoneum; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid*; D011183:Postoperative Complications / Q000175:diagnosis* / Q000201:enzymology; D011559:Pseudotumor Cerebri / Q000201:enzymology / Q000601:surgery; D009418:S100 Proteins / Q000134:cerebrospinal fluid*; D016896:Treatment Outcome
D007527:Isoenzymes; D009418:S100 Proteins; D003402:Creatine Kinase; D010751:Phosphopyruvate Hydratase