Salicylic acid disposition in children with rheumatoid arthritis.
The plasma level profile of SA and SUA after a single oral dose of ASA was studied in 8 children with juvenile rheumatoid arthritis, aged 3.5-15.0 years. Pharmacokinetic parameters were on average similar to those reported in the literature for adult subjects, although a somewhat larger intersubject variability was found.
Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
N
N
Barzaghi
G
G
Lamedica
G
G
Gatti
F
F
Cottafava
D
D
Massocco
N
N
Marchese
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006626:Hippurates / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D006801:Humans; D008297:Male; D012459:Salicylates / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D020156:Salicylic Acid
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006626:Hippurates; D012459:Salicylates; C000693:salicylurate; D020156:Salicylic Acid