Antibacterial effectiveness of ciprofloxacin 0.3% ophthalmic solution in the treatment of bacterial conjunctivitis.
Two hundred eighty-eight cases of culture-proven bacterial conjunctivities were evaluated as part of two multicentered, randomized, prospective clinical studies comparing the antibacterial efficacy of topically administered ciprofloxacin 0.3% either with a placebo or with tobramycin 0.3%. In the first study, ciprofloxacin was significantly (P less than .001) more effective than the placebo. It eradicated or reduced the various bacterial pathogens in 93.6% of patients, compared to 59.5% for the placebo. In the second study, ciprofloxacin (94.5%) and tobramycin (91.9%) were equally effective. Topically applied ciprofloxacin eradicated or reduced all isolated bacterial species, attesting to its broad antibacterial spectrum and its potential usefulness in treating external ocular infections.
Department of Ophthalmology, Boston University School of Medicine, Massachusetts 02118.
H M
HM
Leibowitz
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy*; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D003231:Conjunctivitis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D009883:Ophthalmic Solutions; D011446:Prospective Studies; D014031:Tobramycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions; D002939:Ciprofloxacin; D014031:Tobramycin