Interstitial pneumonitis associated with "crack" cocaine abuse.
A 33-year-old woman developed acute bilateral pulmonary infiltrates after the intense use of rock cocaine (crack). She subsequently had progressive deterioration of pulmonary function to the point of being ventilator-dependent. Open lung biopsy showed a chronic interstitial pneumonia with extensive accumulation of free silica within histiocytes associated with mild pulmonary fibrosis. This pattern of interstitial pneumonia has not been previously reported in crack users.
O'Donnell
A E
AE
Department of Medicine, Robert L. Thompson Strategic Hospital, Carswell AFB, Texas.
Mappin
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FG
Sebo
T J
TJ
Tazelaar
H
H
D000328:Adult; D016578:Crack Cocaine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000175:diagnosis; D012829:Silicosis / Q000209:etiology / Q000473:pathology; D019966:Substance-Related Disorders / Q000150:complications*
D016578:Crack Cocaine