Sequence analysis of the variable region of a mouse gene encoding a monoclonal anti-idiotypic antibody that detects a restricted idiotype on anti-HIV-1 gp160.
We have sequenced the cDNAs encoding the variable (V) regions from the light and heavy chains of a monoclonal anti-idiotypic antibody (Ab), designated MC1, that, when used as an immunogen, activates regulatory idiotypes associated with anti-HIV-1 gp 160 responses. This anti-Id represents a non-antigen-mimicking subclass of Ab-2 referred to as non-internal image. The gene family selections and sequence homologies are presented.
Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147.
K L
KL
Lohman
M A
MA
Carrillo
R C
RC
Kennedy
D000595:Amino Acid Sequence; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000235:genetics*; D000911:Antibodies, Monoclonal / Q000235:genetics*; D001483:Base Sequence; D004247:DNA; D015686:Gene Products, env / Q000235:genetics / Q000276:immunology*; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies / Q000235:genetics*; D019302:HIV Envelope Protein gp160; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000235:genetics / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D015686:Gene Products, env; D015483:HIV Antibodies; D019302:HIV Envelope Protein gp160; D007135:Immunoglobulin Variable Region; D011498:Protein Precursors; D004247:DNA