Indobufen versus placebo in the prevention of restenosis after carotid endarterectomy: a double-blind pilot study.
A randomized clinical trial was undertaken to assess the efficacy of indobufen in inhibiting platelet adhesiveness in carotid thromboendarterectomy. The patients were treated under double-blind conditions with indobufen and with placebo, and were then assessed by means of scintigraphy with labelled platelets, ultrasonic tomography and angiography for a minimum follow-up period of 6 months. Haematological and clinical assessments were also performed. The results of the study suggest that platelet accumulation in carotid endarterectomy may be an early sign of restenosis; anti-aggregant treatment with indobufen carried out at an early stage prior to surgery inhibited platelet accumulation. The final result showed that anti-aggregant treatment had a positive influence on the short- and medium-term outcome of carotid endarterectomy.
Department of Vascular Surgery, University of Florence, Italy.
C
C
Pratesi
R
R
Pulli
G
G
Milanesi
M
M
Lavezzari
F
F
Pamparana
D
D
Bertini
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000188:drug therapy / Q000601:surgery*; D002340:Carotid Artery Diseases / Q000097:blood / Q000188:drug therapy / Q000601:surgery*; D004311:Double-Blind Method; D004691:Endarterectomy; D005260:Female; D006801:Humans; D054833:Isoindoles; D008297:Male; D008875:Middle Aged; D010654:Phenylbutyrates / Q000627:therapeutic use*; D010865:Pilot Projects; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012008:Recurrence
D054833:Isoindoles; D010654:Phenylbutyrates; D010975:Platelet Aggregation Inhibitors; C020371:indobufen