[Membranotropic action of cardiotonic agents and ubiquinone].
Interaction of cardiotonic drugs (strophantidine acetate, suphan, para-oxybenzoic acid) and ubiquinone with phospholipid bilayers has been studied. Exothermic effect of the reaction followed by an increase in microviscosity and hydrophobicity of the bilayer from cardiolipin, but by a decrease of the microviscosity of the bilayer from lecithin has been estimated. A correlation is observed between changes in the lecithin bilayer fluidity and the heat effect of the interaction at the initial period of time after mixing of reagents.
Chekman
I S
IS
Goriushko
A G
AG
Mel'nik
I Iu
IIu
Sachenko
L G
LG
D000818:Animals; D002316:Cardiotonic Agents; D002462:Cell Membrane / Q000187:drug effects; D008051:Lipid Bilayers; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits; D013050:Spectrometry, Fluorescence; D014451:Ubiquinone / Q000494:pharmacology*
D002316:Cardiotonic Agents; D008051:Lipid Bilayers; D010743:Phospholipids; D014451:Ubiquinone
Membranotropnoe deĭstvie kardiotonicheskikh sredstv i ubikhinona.