Dietary fat saturation affects hepatocyte insulin binding and glucose metabolism in BHE rats.
The influence of feeding 6% hydrogenated coconut oil, corn oil or menhaden oil on hepatocyte insulin binding, receptor number and glucose use was studied. Hepatocytes isolated from rats fed menhaden oil had a significantly greater affinity for insulin than hepatocytes from rats fed hydrogenated coconut oil. Glucose use was not influenced by diet; uniformly labeled glucose was metabolized to CO2 or to lipid similarly in cells isolated from rats fed the three oils. Thus, dietary fat type in a low fat diet influenced events at the plasma membrane without influencing intracellular events.
Department of Foods and Nutrition, University of Georgia, Athens 30602.
J S
JS
Pan
C D
CD
Berdanier
D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D000074263:Coconut Oil; D003059:Cocos / Q000737:chemistry; D003314:Corn Oil / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D005395:Fish Oils / Q000008:administration & dosage; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010938:Plant Oils; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000187:drug effects* / Q000378:metabolism
D004041:Dietary Fats; D005395:Fish Oils; D007328:Insulin; D010938:Plant Oils; D002245:Carbon Dioxide; C033266:Menhaden oil; D003314:Corn Oil; D000255:Adenosine Triphosphate; D011972:Receptor, Insulin; D005947:Glucose; D000074263:Coconut Oil