[Skin penetration of antimicrobial agents in rats].
Skin penetration of various antimicrobial agents was studied in rats. Skin concentration/serum concentration ratios were classified into three groups, i.e. group I with ratio greater than or equal to 0.7, group II with the ratio 0.7-0.4 and group III with the ratio less than or equal to 0.4. The drugs of group I were OFLX, CPFX, LFLX, FLRX, SPFX, AMK, EM, RXM, CAM, CLDM. The drugs of group II were ABPC, CVA/AMPC, CVA/TIPC, CEX, CED, CXD, CTM-HE, CXM-AX, CPZ, CBPZ, TFLX, ASTM, MINO. The drugs of group III were AMPC, CCL, CDX, CPDX-PR, CFTM-PI, CTZ, CEC, CEZ, CTM, CMZ, CZON, MCR, IPM/CS. Factors which may influence the skin penetration were discussed, but no definite conclusion has not been obtained.
Department of Dermatology, Okayama University Medical School.
H
H
Akiyama
R
R
Torigoe
T
T
Yamada
Y
Y
Abe
K
K
Simoe
H
H
Kanzaki
J
J
Arata
O
O
Akagi
Y
Y
Yamamoto
M
M
Ikeda
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption
D000900:Anti-Bacterial Agents