Differential effects of antidepressant treatments on fenfluramine-induced increases in plasma prolactin and corticosterone in rats.
Intravenous administration of 5-HT releasing agent, fenfluramine, to rats produced increases in plasma prolactin and corticosterone concentrations. Short-term or long-term treatment with either clorgyline or imipramine did not affect baseline levels of prolactin or corticosterone. On the other hand, short-term but not long-term lithium treatment significantly increased baseline levels of corticosterone but not of prolactin. Short-term treatment with lithium but not clorgyline or imipramine potentiated fenfluramine-induced increases in plasma prolactin but not corticosterone. On the other hand, long-term treatment with clorgyline but not imipramine or lithium attenuated fenfluramine's effect on plasma prolactin but not on corticosterone. These findings demonstrate differential effects of antidepressant treatments on fenfluramine-induced increases in plasma prolactin and corticosterone in rats and are consistent with several other clinical and animal studies demonstrating dissimilar actions of different antidepressant treatments on two different 5-HT-mediated neuroendocrine functions.
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
C S
CS
Aulakh
J
J
Zohar
K M
KM
Wozniak
J L
JL
Hill
M
M
Haass
D L
DL
Murphy
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003010:Clorgyline / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood*; D004347:Drug Interactions; D005277:Fenfluramine / Q000008:administration & dosage / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology; D007275:Injections, Intravenous; D008094:Lithium / Q000494:pharmacology; D008297:Male; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D000928:Antidepressive Agents; D005277:Fenfluramine; D011388:Prolactin; D008094:Lithium; D003010:Clorgyline; D007099:Imipramine; D003345:Corticosterone