Clonidine decreases postoperative oxygen consumption in patients recovering from general anaesthesia.
Twenty ASA I patients, undergoing thyroid surgery were allocated randomly to receive at the end of surgery either an isotonic saline solution or clonidine 2 micrograms kg-1 i.v. administered over 20 min. Oxygen consumption (VO2) and carbon dioxide production (VCO2) were measured during recovery in patients breathing spontaneously with a head canopy system. Clonidine was found to attenuate the increase in VO2 and VCO2 associated with recovery from anaesthesia. The effect of clonidine was associated with a reduction in shivering. Sedative and analgesic properties of clonidine may also contribute to the reduction in metabolic demand during recovery from anaesthesia.
Service d'Anesthésie Réanimation, Hôpital Henri Mondor, Créteil, France.
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L
Delaunay
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F
Bonnet
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P
Duvaldestin
D000328:Adult; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000009:adverse effects*; D002245:Carbon Dioxide / Q000378:metabolism; D003000:Clonidine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D010149:Postoperative Pain / Q000188:drug therapy; D011184:Postoperative Period; D012768:Shivering / Q000187:drug effects*; D013959:Thyroid Diseases / Q000601:surgery; D013961:Thyroid Gland / Q000601:surgery
D002245:Carbon Dioxide; D003000:Clonidine