Hereditary disorders in Saguenay-Lac-St-Jean (Quebec, Canada).
Saguenay-Lac-St-Jean is a geographically isolated region located in northeastern Quebec. Opened to the white settlement in 1938, its immigrants mainly came from Charlevoix, another isolated region of Quebec. The prevalence and/or incidence of several autosomal dominant and recessive disorders are very high. The overall birth prevalence of the recessive disorders was calculated at 1/207 living births and the overall carrier rate at 1/7 inhabitants. This situation may be explained by migration and social factors.
SOREP, Université du Québec à Chicoutimi, Canada.
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De Braekeleer
D005799:Genes, Dominant; D005808:Genes, Recessive; D030342:Genetic Diseases, Inborn / Q000453:epidemiology*; D005828:Genetics, Population; D006801:Humans; D015994:Incidence; D015995:Prevalence; D011792:Quebec / Q000453:epidemiology; D012423:Rural Health