Treatment of mice with a herbal preparation (Liv. 52) reduces the frequency of radiation-induced chromosome damage in bone marrow.
Induction of chromosomal aberrations was studied from 1/4 to 14 days post irradiation in the bone marrow of mice treated or not with Liv. 52, a herbal preparation, prior to 4.5 Gy exposure. The frequency of chromatid and chromosomal aberrations started increasing at day 1/4 in the irradiation and Liv. 52 + irradiated groups. The highest frequency of aberrations was recorded at day 1/2 post exposure which declined after day 1 in both groups. The frequency of both types of aberrations was significantly lower in the Liv. 52 + irradiated group than in the irradiated group.
Department of Radiobiology, Kasturba Medical College, Manipal, India.
G C
GC
Jagetia
N G
NG
Ganapathi
D000782:Aneuploidy; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations; D004338:Drug Combinations; D005720:Gamma Rays / Q000009:adverse effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014916:Whole-Body Irradiation / Q000009:adverse effects
D004338:Drug Combinations; D010936:Plant Extracts; D011837:Radiation-Protective Agents; C002614:Liv 52