[PCB methyl sulphone: comparison of tissue levels in Baltic grey seals and a Yusho patient].
Methyl sulphone metabolites of PCB and DDE were isolated from different tissues of a Baltic grey seal (Halichoerus grypus). Main components in the seal blubber were identified as 3-MeSO2-2,2',4',5,5'-pentaCB, 4-MeSO2-2,2',4',5,5'-pentaCB, 3-MeSO2-p,p'-DDE, 4-MeSO2-2,2',3',4',5-pentaCB and 4-MeSO2-2,2',3,4',5',6-hexaCB. Liver and lung in the seal contained different MeSO2-PCB pattern compared to all other tissues. These levels in the both tissues were estimated to be 28 and 15 ppm (lipid basis) which corresponded to the same level as the PCB. Concentrations of MeSO2-PCB in any tissues of a Yusho patient were low compared to those in the seal.
Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan.
K
K
Haraguchi
Y
Y
Masuda
A
A
Bergman
M
M
Olsson
D000818:Animals; D005506:Food Contamination; D006801:Humans; D012275:Oryza / Q000506:poisoning; D010938:Plant Oils / Q000506:poisoning; D011041:Poisoning / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics / Q000506:poisoning*; D046048:Seals, Earless / Q000378:metabolism*; D013450:Sulfones / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D010938:Plant Oils; D013450:Sulfones; D011078:Polychlorinated Biphenyls