Ciprofloxacin interaction with sodium warfarin: a potentially dangerous side effect.
Ciprofloxacin, a quinolone antibiotic which exhibits minimal side effects and has broad antimicrobial spectrum, is being used frequently to treat various infections. A patient is reported who had previously maintained a stable prothrombin time on Coumadin for 5 years, and who exhibited a marked prolongation of prothrombin time when placed on ciprofloxacin for gastroenteritis.
Yale University School of Medicine, New Haven, CT.
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Renzi
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Finkbeiner
D002939:Ciprofloxacin / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D012449:Safety; D014859:Warfarin / Q000009:adverse effects*
D002939:Ciprofloxacin; D014859:Warfarin