[The inhibiting effect of cimetidine on a number of enzymes].
The results of the comparative study on the contents and activity of the enzymes of the system of oxidases of mixed function in the lungs and liver in rabbits, the specific features of phospholipid spectrum in the supernatant and microsomal fractions of the lungs and liver tissues are presented. The same parameters were investigated in experimental chronic inflammatory diseases of the lungs. The degree of the damage of the monoxygenase capacity of the lungs and the degree of the liver involvement in the process were established. The peculiarities of the inhibitory action of cimetidine on the detoxication capacity of the lungs and liver and on the disorder of the reproduction of phospholipids in these organs were revealed. The substrate specificity of cimetidine in inhibition of microsomal NADPN-cytochrome-C-reductase both in the liver and in the lungs, the probability of blocking the synthesis of phospholipids at the level of phosphatide acid and citidinephosphatecholine were noted. The results obtained should be taken into consideration during drug therapy.
Usmanov
R I
RI
Iakubov
A A
AA
Karimov
M M
MM
Zueva
E B
EB
D000818:Animals; D002908:Chronic Disease; D002927:Cimetidine / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008168:Lung / Q000187:drug effects / Q000201:enzymology; D008297:Male; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors; D010743:Phospholipids / Q000378:metabolism; D011014:Pneumonia / Q000188:drug therapy / Q000201:enzymology; D011817:Rabbits; D013379:Substrate Specificity / Q000187:drug effects
D004791:Enzyme Inhibitors; D010743:Phospholipids; D002927:Cimetidine; D006899:Mixed Function Oxygenases
Ingibiruiushchee vliianie tsimetidina na riad fermentov.