[Treatment with indomethacin for the control of the metabolic disorder caused by a villous adenoma of the rectum].
A 79 year old patient with a previous history of 10 months of mucous diarrhea is admitted due to pre-renal insufficiency, hyponatremia, hypokalemia and metabolic alkalosis secondary to rectal villous adenoma. The volume of the rectal discharge was 2.500 cc/day. Sodium level of the rectal secretion was 145 mEq/L and potassium 20 mEq/L. E2 prostaglandin: 1500 pg/ml. After hydroelectrolytic treatment, a PG synthetase inhibitor (indomethacin) was added to a dosage of 25 mg q/d PO. Rectal discharge was reduced to 500 cc/day, as well as sodium and prostaglandin levels. It has been proved that the use of PG synthetase inhibitors can facilitate the preparatory metabolic control in patients with villous adenoma.
Cutrin Prieto
C
C
Servicio de Medicina Interna, Hospital General de Galicia-Gil Casares.
Casal Iglesias
L
L
Batalla Eiras
A
A
Meniño Olveira
M J
MJ
Diéguez Gómez
P
P
Lorenzo Zúniga
V
V
D000236:Adenoma / Q000150:complications*; D000368:Aged; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D012004:Rectal Neoplasms / Q000150:complications*; D014883:Water-Electrolyte Imbalance / Q000188:drug therapy* / Q000209:etiology
D007213:Indomethacin
Tratamiento con indometacina para el control del trastorno metabólico producido por un adenoma velloso de recto.