In vitro activities of aminoglycosides, lincosamides, and rifamycins against Mycobacterium leprae.
The in vitro activities of a variety of aminoglycosides, lincosamides, and rifamycins against Mycobacterium leprae were evaluated with the BACTEC 460 system. At 20 micrograms/ml, gentamicin, kanamycin, tobramycin, streptomycin, and amikacin were inactive. Lincomycin was active at 20 micrograms/ml, and clindamycin was active at 0.31 micrograms/ml. Rifamycin SV, rifabutin, and rifampin were active at 3.1, 3.1 to 12.5, and 200 ng/ml, respectively. The in vitro assay correlates well with the in vivo response of M. leprae to antimicrobial agents, with the exception of the aminoglycosides.
Franzblau
S G
SG
Laboratory Research Branch, Gillis W. Long Hansen's Disease Center, Carville, Louisiana 70721.
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D055231:Lincosamides; D018942:Macrolides; D051379:Mice; D008819:Mice, Nude; D008826:Microbial Sensitivity Tests; D009166:Mycobacterium leprae / Q000187:drug effects*; D012294:Rifamycins / Q000494:pharmacology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D055231:Lincosamides; D018942:Macrolides; D012294:Rifamycins