The TSH receptor in autoimmune Basedow's disease.
The cloning approaches of the past two years have opened new doors to the pursuit of our understanding Basedow's disease. The cloning of the TSH receptor is the most dramatic step; nevertheless, all the proteins mentioned in the following appear to be important molecules in the bioactivity of the thyroid cell and are implicated as autoantigens.
Akamizu
T
T
Section on Cell Regulation, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda.
Saji
M
M
Ikuyama
S
S
Kosugi
S
S
Tahara
K
K
Kohn
L D
LD
D000595:Amino Acid Sequence; D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001483:Base Sequence; D003001:Cloning, Molecular; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D011989:Receptors, Thyrotropin / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D011989:Receptors, Thyrotropin