Epidermolysis bullosa acquisita in identical twins.
Identical twin sisters developed generalized erythema and bullae on skin and mucous membranes at 18 and 19 years of age. Atrophic scars and milia were formed later. Indirect immunofluorescence (IF) study of the separated skin by incubation in 1.0M NaCl showed antibasement membrane zone (BMZ) antibodies bound to the dermal side. The HLA-DR typing demonstrated DR2/DW11. Pulse therapy resulted in marked clinical improvement. This is the first report of epidermolysis bullosa acquisita (EBA) in identical twins and suggests the possibility that the disease may have a genetic component.
Department of Dermatology, University of Ehime School of Medicine, Japan.
S
S
Murakami
S
S
Shiraishi
Y
Y
Miki
D000293:Adolescent; D000328:Adult; D004200:Diseases in Twins; D016107:Epidermolysis Bullosa Acquisita / Q000235:genetics*; D005260:Female; D006801:Humans; D014430:Twins, Monozygotic