[Effect of selenium on myocardial function and structure in mice within ischemic and hypoxic environment].
The experiment was designed to study the protective effect of selenium on myocardial function and ultrastructure changes of fetal mouse heart model under ischemic and hypoxic circumstances. The results showed that selenium can prolong the period of heart surviving and beating. Results via lanthanum probe technique indicated that selenium is able to maintain the functional integrity of the myocardial cell membrane as well as the mitochondria membrane. Ultrastructure changes under REM suggested that selenium may play a role in delaying the development of irreversible myocardial injury and to promote protein synthesis and the repairment of the injured cells.
Zhu
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Department of Pathology, Institute of Basic Science of Medicine, Shenyang.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D005318:Fetal Heart / Q000187:drug effects* / Q000502:physiology; D000860:Hypoxia / Q000473:pathology; D066298:In Vitro Techniques; D007511:Ischemia / Q000473:pathology; D051379:Mice; D008929:Mitochondria, Heart / Q000187:drug effects; D009206:Myocardium / Q000473:pathology*; D012643:Selenium / Q000494:pharmacology*
D012643:Selenium