MMPI measures of impulsivity and depression correlate with CSF 5-HIAA and HVA in depression but not schizophrenia.
Recent studies have linked impulsivity with CSF concentrations of both 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA). One work found a negative correlation between the MMPI psychopathic deviate (Pd) scale and 5-HIAA in personality disordered men (Brown et al., 1982). We found that the 5-HIAA/Pd correlation extends (P less than 0.05) to unmedicated depressed patients (n = 21). A trend was found between HVA and Pd in depression. There was no relationship between either metabolite and the Pd scale in unmedicated schizophrenics (n = 24). A significant inverse correlation was found between the MMPI depression scale and CSF HVA but not 5-HIAA in the depressed patients.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305.
W O
WO
Faustman
R J
RJ
King
K F
KF
Faull
J A
JA
Moses
K L
KL
Benson
V P
VP
Zarcone
J G
JG
Csernansky
D000328:Adult; D003866:Depressive Disorder / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000523:psychology; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D007175:Impulsive Behavior / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000523:psychology; D008950:MMPI / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D012565:Schizophrenic Psychology
D006719:Homovanillic Acid