Immunomodulatory activity of three Sri-Lankan medicinal plants used in hepatic disorders.
The effects of aqueous extracts of Osbeckia octandra whole plant, Melothria maderaspatana whole plant and Phyllanthus debelis leaves on the human immune system were investigated. The extracts showed strong anticomplement effects on both the classical and alternate pathways of the human complement system in vitro. The effects were dose-dependent and most pronounced in the classical complement pathway assay. The extracts also exhibited a direct dose-dependent inhibition of luminol-induced chemiluminescence of human polymorphonuclear leukocytes upon stimulation with zymosan.
Thabrew
M I
MI
Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri-Lanka.
de Silva
K T
KT
Labadie
R P
RP
de Bie
P A
PA
van der Berg
B
B
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D003170:Complement Pathway, Alternative / Q000187:drug effects; D003171:Complement Pathway, Classical / Q000187:drug effects; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D008107:Liver Diseases / Q000188:drug therapy*; D008163:Luminescent Measurements; D008165:Luminol / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012119:Respiration / Q000187:drug effects; D016897:Respiratory Burst / Q000187:drug effects; D013188:Sri Lanka
D000276:Adjuvants, Immunologic; D010936:Plant Extracts; D008165:Luminol