Blast transformation in chronic myeloid leukemia with synovial involvement.
In a patient with chronic myeloid leukemia in blastic transformation, the blast cells in a knee joint effusion were identical morphologically to those in the marrow. Cytochemical and immunocytochemical studies showed that these blasts were primitive erythroblasts and not granulocytic or monocytic precursors. The combined use of cytologic, cytochemical and immunocytochemical techniques will help to accurately identify cells in joint effusions and to elucidate the mechanism of synovial involvement by hematologic disorders.
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905.
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D000368:Aged; D015415:Biomarkers; D001752:Blast Crisis / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007719:Knee Joint; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D008297:Male; D013582:Synovial Fluid / Q000166:cytology*
D015415:Biomarkers