Glutathione peroxidase in early and advanced Parkinson's disease.
A defective antioxidant scavenging system plays a major role in one of the theories of the pathogenesis of Parkinson's disease. The aim of this study was to investigate whether there is a general difference in antioxidant activity between early and advanced cases of Parkinson's disease. Twenty five recently diagnosed patients, without any clinical fluctuations (group A), and 25 patients in a late phase of the disease with severe fluctuations in response to levodopa therapy (group B) were included in the study. Erythrocyte glutathione peroxidase was determined as a measure of antioxidant activity and significantly lower values were found in group B than in group A. Regression analyses in groups A and B showed significant correlation between glutathione peroxidase and duration of disease, but not between glutathione peroxidase and age of patients.
Department of Neurology, University Hospital, Aarhus Kommunehospital, Aarhus, Denmark.
P
P
Johannsen
G
G
Velander
J
J
Mai
E B
EB
Thorling
E
E
Dupont
D000368:Aged; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000175:diagnosis / Q000201:enzymology*; D012643:Selenium / Q000097:blood*
D005979:Glutathione Peroxidase; D012643:Selenium