Imipramine treatment of ADHD in a fragile X child.
Fragile X syndrome, an X-linked genetic disorder, is the third most common cause of mental retardation. The following is a case of a 6-year-old boy with fragile X syndrome and its characteristic cognitive and behavioral symptomatology, including attention deficit hyperactivity disorder. In addition, this child experienced initial insomnia and nocturnal enuresis, problems not previously reported with fragile X. Previous pharmacological treatment of the syndrome's behavioral difficulties and attention deficit has included stimulants, folic acid, and neuroleptics. This is the first report of the successful use of imipramine. Imipramine also improved the boy's insomnia and enuresis, whereas methylphenidate caused an overall worsening of his condition.
Department of Psychiatry, University of Kentucky College of Medicine, University of Kentucky, Lexington 40536-0080.
D K
DK
Hilton
C A
CA
Martin
W M
WM
Heffron
B D
BD
Hall
G L
GL
Johnson
D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004775:Enuresis / Q000188:drug therapy / Q000523:psychology; D005600:Fragile X Syndrome / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy / Q000523:psychology
D007099:Imipramine