Ewing's sarcoma t(11;22) in a case of acute nonlymphocytic leukemia.
Chromosome analysis of bone marrow cells from a patient with acute nonlymphocytic leukemia M2 revealed the translocation t(11;22)(q24;q12) usually associated with Ewing's sarcoma. Molecular investigations ruled out the possibility that this was a variant Philadelphia translocation with breakpoints in the major breakpoint cluster region. Although cytogenetic analysis was not available at diagnosis, this abnormality was found both pre- and postallogeneic bone marrow transplant.
Cytogenetics, Royal Free Hospital Medical School, London, UK.
J M
JM
Hawkins
J M
JM
Craig
L M
LM
Secker-Walker
H G
HG
Prentice
A B
AB
Mehta
D000293:Adolescent; D015139:Blotting, Southern; D001853:Bone Marrow / Q000648:ultrastructure; D002881:Chromosomes, Human, Pair 12; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D012512:Sarcoma, Ewing / Q000235:genetics*; D014178:Translocation, Genetic