Marsupial possum neurotensin: a unique mammalian regulatory peptide exhibiting structural homology to the avian analogue.
Neurotensin has been isolated from small intestinal extracts of an Australian marsupial, the brush-tailed possum (Trichosurus vulpecula). The primary structure was determined as: pGlu-Leu-His-Val-Asn-Lys-Ala-Arg-Arg-Val-Tyr-Ile-Leu. When compared with bovine neurotensin, marsupial possum neurotensin exhibits four amino acid substitutions. His for Tyr3, Val for Glu4 and Ala for Pro7 are identical with those found in chicken neurotensin. In addition, substitution of Pro10 with Val is unique among all neurotensins sequenced to date. Marsupial possum neurotensin is therefore of unique primary structure, displaying most sequence homology with its avian counterpart. This neurotensin may thus resemble the phylogenetic precursor present at the time of divergence of primitive mammals and birds.
Department of Medicine, Queen's University of Belfast, Northern Ireland.
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Shaw
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Murphy
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Thim
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Furness
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Buchanan
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002645:Chickens; D004386:Duodenum / Q000737:chemistry; D006168:Guinea Pigs; D007082:Ileum / Q000737:chemistry; D007150:Immunohistochemistry; D008297:Male; D008969:Molecular Sequence Data; D009496:Neurotensin / Q000737:chemistry* / Q000302:isolation & purification; D009893:Opossums; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
D010455:Peptides; D009496:Neurotensin