Benign and malignant neoplasms in a family with Peutz-Jeghers syndrome: study of three generations.
Three members of a family with Peutz-Jeghers syndrome had intussusception due to intestinal hamartomas. In addition, the grandfather had carcinoma of the jejunum, and the granddaughter had benign ovarian sex cord/stromal tumor causing sexual precocity. Benign and malignant tumors, not often associated with Peutz-Jeghers syndrome, pose a further threat in addition to the gastrointestinal bleeding and obstruction that often complicate this inherited syndrome.
School of Primary Medical Care, University of Alabama, Huntsville.
E H
EH
Laughlin
D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D002648:Child; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007580:Jejunal Neoplasms / Q000473:pathology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000473:pathology*; D010375:Pedigree; D010580:Peutz-Jeghers Syndrome / Q000235:genetics / Q000473:pathology*