Demonstration of flufenamic acid in histological sections.
A simple method is described to show the transdermal penetration of flufenamic acid (CAS 530-78-9) into the skin of laboratory animals. After topical application of gels and creams containing flufenamic acid the substance exerts a fluorescent painting in corium and subcutis of histological slides. This effect needs the chemical reaction between the test substance and sulphuric acid in synthetic resin sections.
Elling
H
H
Pharmacological Laboratories, Chemisch-Pharmazeutische Fabrik, Munich, Fed. Rep. of Germany.
D000818:Animals; D005260:Female; D005439:Flufenamic Acid / Q000737:chemistry / Q000378:metabolism*; D005453:Fluorescence; D005557:Formaldehyde; D006168:Guinea Pigs; D006651:Histocytochemistry; D051379:Mice; D008819:Mice, Nude; D011817:Rabbits; D012116:Resins, Plant; D012867:Skin / Q000737:chemistry / Q000166:cytology; D013464:Sulfuric Acids
D012116:Resins, Plant; D013464:Sulfuric Acids; D005557:Formaldehyde; D005439:Flufenamic Acid