Severe fetal hydrops resulting from ABO incompatibility.
Severe fetal hydrops was diagnosed at 34 weeks' gestation. Funipuncture revealed a normal 46,XX karyotype and a hematocrit of 20%. Cesarean delivery was performed. Neonatal blood testing showed blood type B positive, positive direct and indirect Coombs, and an anti-B antibody titer of 1:64. The maternal blood group was O positive with a titer of 1:65,536 immunoglobulin G (IgG) anti-B antibody (after inactivation of IgM anti-B antibody). This report documents a rare case of fetal hydrops resulting from ABO incompatibility with neonatal survival.
Department of Obstetrics and Gynecology, Strong Memorial Hospital, Rochester, New York.
D M
DM
Sherer
J S
JS
Abramowicz
R M
RM
Ryan
L A
LA
Sheils
N
N
Blumberg
J R
JR
Woods
D000017:ABO Blood-Group System; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D001787:Blood Group Incompatibility / Q000097:blood / Q000150:complications* / Q000276:immunology; D002585:Cesarean Section; D003298:Coombs Test; D005260:Female; D006400:Hematocrit; D006801:Humans; D015160:Hydrops Fetalis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D007074:Immunoglobulin G / Q000276:immunology; D007621:Karyotyping; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000276:immunology; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis
D000017:ABO Blood-Group System; D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G