Polymorphisms in oxidative drug metabolism: relationship to food preference.
To determine whether a correlation exists between polymorphisms of oxidative drug metabolism and dietary preference, 29 poor metabolizers of dextromethorphan, 18 poor metabolizers of mephenytoin and 134 extensive metabolizers of both drugs were screened for their preferences for various food items. Poor metabolizers of dextromethorphan showed a diminished stated preference for cauliflower and coconut, and poor metabolizers of mephenytoin showed a diminished stated preference for spinach and cabbage.
College of Pharmacy, University of Kentucky, Lexington 40536.
M R
MR
Britto
H E
HE
McKean
G G
GG
Bruckner
P J
PJ
Wedlund
D000328:Adult; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003915:Dextromethorphan / Q000378:metabolism; D005518:Food Preferences / Q000502:physiology*; D006801:Humans; D008297:Male; D008617:Mephenytoin / Q000378:metabolism; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010641:Phenotype; D011110:Polymorphism, Genetic; D011795:Surveys and Questionnaires
D004364:Pharmaceutical Preparations; D003915:Dextromethorphan; D003577:Cytochrome P-450 Enzyme System; D008617:Mephenytoin