Intravenous immunoglobulins (IVIg) in the treatment of autoimmune diseases.
Intravenous immunoglobulin (IVIg) therapy is increasingly used in autoimmune diseases. Although its efficacy has only been established in a few specific antibody-mediated autoimmune conditions, accumulating evidence on the regulatory role of circulating immunoglobulins in the selection of peripheral B cell repertoires makes it an attractive potential therapeutic option to clinical immunologists. This overview briefly discusses the current use of IVIg in human autoimmune diseases with a particular emphasis on the possible mechanisms by which IVIg could suppress pathological autoimmune responses.
Kaveri
S V
SV
INSERM U28, Paris, France.
Dietrich
G
G
Hurez
V
V
Kazatchkine
M D
MD
D016525:Antigenic Modulation; D001327:Autoimmune Diseases / Q000628:therapy*; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007135:Immunoglobulin Variable Region / Q000502:physiology; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007167:Immunotherapy
D007141:Immunoglobulin Fc Fragments; D007135:Immunoglobulin Variable Region; D016756:Immunoglobulins, Intravenous