Do measles early giant cells result from fusion of non-infected cells? An immunohistochemical and in situ hybridization study in a case of morbillous appendicitis.
A case of acute appendicitis with features of measles inflammatory reaction is studied. Two types of lymphoid polykaryons are seen: Warthin Finkeldey cells inside germinal centres (LN1 ++, LN2 +, L26 +, MB1 +, MB2 +/-) and multinucleate plasma cells in the lamina propria (mu +, alpha ++, kappa +, lambda +). Both types of polykaryon are devoid of inclusions. The search for viral genetic information by in situ hybridization was negative in these cells. A positive signal was observed in interfollicular mononuclear cells and rare enterocytes. A possible mechanism of fusion from without, acting at the beginning of the disease to induce the appearance of polykaryons, is discussed.
Gaulier
A
A
Service d'Anatomìe Cytologìe Pathologìques, Hospital V. Dupouy, Argenteuil, France.
Sabatier
P
P
Prevot
S
S
Fournier
J G
JG
D000208:Acute Disease; D001064:Appendicitis / Q000382:microbiology* / Q000473:pathology; D002459:Cell Fusion; D002648:Child; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D008297:Male; D008457:Measles / Q000382:microbiology / Q000473:pathology*; D008459:Measles virus / Q000235:genetics; D009693:Nucleic Acid Hybridization; D010950:Plasma Cells / Q000473:pathology
D004279:DNA, Viral