Immunosuppressive therapy in bone marrow transplantation.
Immunosuppressive and immunomodulatory techniques have a central role in bone marrow transplantation (BMT). A wide range of agents with different mechanisms of action, including steroids, cyclosporin, cytotoxic agents, irradiation and monoclonal antibodies are used to achieve the following treatment aims: (1) Suppression of the recipient's immunity to permit donor marrow engraftment and prevent graft rejection; (2) Prevention of graft versus host disease (GvHD); (3) Treatment of established acute or chronic GvHD.
Barrett
A J
AJ
Department of Haematology, Royal Postgraduate Medical School, University of London, Hammersmith Hospital, U.K.
D016026:Bone Marrow Transplantation; D005544:Forecasting; D006085:Graft Survival / Q000187:drug effects / Q000528:radiation effects; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy