Altered lymphocyte populations in sphha/sphha mice with chronic hemolytic anemia.
Lymphocyte kinetics and phenotype were examined in mutant anemic sphha/sphha mice that manifest a lifelong lymphocytosis which accompanies their chronic hemolytic anemia. Anemic mice have significant increases in CD4+, CD8+, and sIgM+ lymphocytes in peripheral blood. Pulse and continuous infusion studies with [3H]TdR suggest that this apparent lymphoid expansion is not due to increased production of lymphocytes in bone marrow or thymus but rather to a redistribution of lymphocytes from the spleen to other peripheral lymphoid tissue sites as well as increased proliferation of T and B lymphocytes in lymph nodes. This murine model could be useful to examine lymphocyte perturbations that may accompany chronic hemolytic anemia in humans.
Department of Comparative Medicine, University of Washington, Seattle 98195.
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L
Maggio-Price
A
A
Grossmann
D
D
Engel
C
C
Rosse
D000745:Anemia, Hemolytic, Congenital / Q000276:immunology*; D000818:Animals; D001854:Bone Marrow Cells; D002455:Cell Division; D002908:Chronic Disease; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000276:immunology; D016131:Lymphocyte Subsets / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D010641:Phenotype; D013049:Spectrin / Q000235:genetics*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000502:physiology
D013049:Spectrin