Enhanced healing of 30 microns Gore-Tex PTFE microarterial prostheses by alcohol-pretreatment.
Polytetrafluoroethylene (PTFE) microvascular prostheses with a fibril length of 30 microns were pretreated with alcohol (n = 18), implanted into the abdominal aorta of rats and were evaluated at 1 day (n = 3), 1 week (n = 3), 3 weeks (n = 6) and 6 weeks (n = 6) to determine whether alcohol-pretreatment might improve their healing. Untreated PTFE microvascular prostheses (n = 18) functioned as controls (all prostheses: length 10 mm, I.D. 1.5 mm). The alcohol-pretreated PTFE microarterial prostheses were initially completely filled and covered with clot and showed fast and complete healing within 6 weeks: endothelial cells and smooth muscle cells on the luminal surface, and the interstices filled with fibrous-like tissue. In contrast, the untreated PTFE prostheses were initially not filled or covered with clot and showed only healing near the anastomotic sites and scarce tissue ingrowth into the wall. These results demonstrate that alcohol-pretreatment improves the healing characteristics of PTFE microarterial prostheses with a fibril length of 30 microns. The alcohol-pretreatment renders the PTFE material more accessible to clot and subsequently to cells.
Department of Surgery, University Hospital Groningen, The Netherlands.
B
B
Van der Lei
J W
JW
Stronck
C R
CR
Wildevuur
D000818:Animals; D001807:Blood Vessel Prosthesis; D004730:Endothelium, Vascular / Q000648:ultrastructure; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D009131:Muscle, Smooth, Vascular / Q000648:ultrastructure; D011138:Polytetrafluoroethylene; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D000431:Ethanol; D011138:Polytetrafluoroethylene