[Which transplantation strategies in primary hyperoxaluria type 1?].
The following main conclusions concerning the transplantation strategies to be adopted in primary hyperoxaluria type 1 (PH1) were drawn from the data collected from 22 patients who received combined liver-kidney grafts and 2 patients who received isolated liver grafts in Europe from June 1984 to March 1990. In end-stage renal failure due to PH1 liver-kidney transplantation yields better results than conventional renal transplantation. An isolated liver graft should be planned in patients with GFR between 25 and 60 ml/min/1.73 m2 whereas a combined liver-kidney graft is to be recommended as soon as the GFR falls below 25 ml/min/1.73 m2. Such patients should not be maintained on dialysis for more than a few months since they would unavoidably develop oxalosis with the risk of disabling lesions in the skeleton and cardiovascular system. Besides, oxalosis would be regularly followed by long-standing hyperoxaluria, with the risk of damage to the kidney graft, despite the correction of the enzyme deficit brought up by the liver graft.
De Pauw
L
L
Cliniques Universitaires de Bruxelles, Hôpital Erasme, Belgique.
Watts
R W
RW
Danpure
C J
CJ
Toussaint
C
C
D005919:Glomerular Filtration Rate; D006801:Humans; D006959:Hyperoxaluria / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation; D016031:Liver Transplantation
Quelles stratégies de transplantation dans l'hyperoxalurie primitive de type 1?