Prevention of cyclosporine enhanced ischaemic renal injury using induced hypothermia.
Cyclosporine is associated with an increased incidence of graft primary non function and poorer long term graft function in patients with prolonged ischaemia times. We evaluated the role of hypothermia in preventing this synergism between the nephrotoxic effects of cyclosporine and ischaemia in a canine model. Induced renal hypothermia prevented this synergism.
Creagh
T A
TA
Department of Surgery, Beaumont Hospital, Dublin, Ireland.
Broe
P J
PJ
Murphy
D M
DM
McLean
P A
PA
Tormey
W
W
Dolan
J
J
Leader
M
M
Walshe
J J
JJ
Bouchier-Hayes
D J
DJ
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs; D007036:Hypothermia, Induced; D007511:Ischemia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D013997:Time Factors
D016572:Cyclosporine