In vitro binding of Helicobacter pylori to human gastric mucin.
The in vitro binding of four Helicobacter pylori strains to human gastric mucin was studied with an enzyme-linked immunosorbent assay. All four strains were found to bind to purified mucin. Neuraminidase treatment and nonspecific oxidation of mucin decreased bacterial adherence to the macromolecule. Mucin preparations were also found to inhibit attachment of H. pylori to HEp-2 monolayers.
Tzouvelekis
L S
LS
Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
Mentis
A F
AF
Makris
A M
AM
Spiliadis
C
C
Blackwell
C
C
Weir
D M
DM
D001422:Bacterial Adhesion; D005753:Gastric Mucosa / Q000382:microbiology*; D016480:Helicobacter pylori / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D066298:In Vitro Techniques; D009077:Mucins / Q000737:chemistry / Q000378:metabolism*
D009077:Mucins