Infectious imaging with indium-111-labeled nonspecific polyclonal human immunoglobulin.
Nonspecific polyclonal immunoglobulin (IgG), prepared from pooled human serum gamma globulin and labeled with 111In has been reported to be equivalent to antigen-specific antibody in the detection of focal infection or inflammation during the first 24 hr after injection. We describe our experience in a Phase II clinical study using 111In-IgG in 15 patients (8 males, 7 females) ranging from 26 to 80 (mean = 50) yr of age with suspected focal infection/inflammation. Pathologic confirmation was obtained in 5/15 cases. A combination of clinical course, laboratory results, and other imaging procedures were used to categorize the other 10 patients. One possible false-negative involved a presumed aspiration pneumonia in a patient with a history of aspiration, bibasilar infiltrates on chest film, and no other identified source of infection. Otherwise, there were 10 confirmed positives, 4 confirmed negatives, and no false-positives. Our findings confirm earlier reports that 111In-IgG may be a superior imaging agent for infection/inflammation with practical advantages over 67Ga-citrate and 111In-labeled leukocytes.
Wegener
W A
WA
Department of Radiology, University of Pennsylvania, Philadelphia 19104.
Velchik
M G
MG
Weiss
D
D
Ter
S
S
Byars
A
A
Neptune
M
M
Alavi
A
A
D004341:Drug Evaluation; D005260:Female; D005490:Focal Infection / Q000000981:diagnostic imaging*; D006801:Humans; D016756:Immunoglobulins, Intravenous; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging
D016756:Immunoglobulins, Intravenous; D007205:Indium Radioisotopes