[Therapy of hypertensive coronary patients. Open long-term study with a combination of atenolol and nifedipine].
In the present study, 20 patients with both hypertension and stabile angina pectoris were treated twice daily for 6 months with 50 mg atenolol and 20 mg retard-formulation nifedipine. The effect of this treatment on blood pressure and heart rate was investigated at rest and under standardized ergometric conditions, and by means of a 24 h Holter ECG. The frequency of angina pectoris episodes in 6-week periods was reduced by 34% over 6 months. The initial decrease in systolic and diastolic blood pressure (by 25%) was maintained over the long term at rest and under exercise. Patient exercise tolerance with reduced oxygen utilization, as represented by the product of pressure x rate, showed a lasting improvement. After 6 months, monotopic ventricular premature beats in particular were reduced significantly (46%) as compared with the initial situation.
Lindner
U K
UK
D000368:Aged; D001262:Atenolol / Q000008:administration & dosage / Q000627:therapeutic use*; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005080:Exercise Test; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use*
D001262:Atenolol; D009543:Nifedipine
Therapie hypertensiver Koronarpatienten. Offene Langzeitstudie mit der Kombination Atenolol plus Nifedipin.