Controlled release from cylindrical microstructures.
Microtubules formed from diacetylenic phosphatidyl-cholines can be made rugged and solvent resistant through electroless deposition of metals (Rudolph et al. 1990). Once dried tubules can capture a range of materials by capillary action when added to a hydrating medium, thus retaining and controlling the release rates of these materials. We report the encapsulation in tubules of a mixture of tetracycline, epoxy monomers and polymers and their in vitro release kinetics in both dynamic and static environments.
Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC.
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D003692:Delayed-Action Preparations; D004337:Drug Carriers; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D011108:Polymers / Q000008:administration & dosage*; D013752:Tetracycline / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D010713:Phosphatidylcholines; D011108:Polymers; D013752:Tetracycline