[An experimental study of tumor-tropic properties of radionuclide-labeled liposomes].
The paper is concerned with the results of experimental investigations to develop methods for obtaining 99mTc and 67Ga-labeled liposomes, possessing tumor-tropic properties. Sphingomyelin vesiculae, labeled with 67Ga with the help of bifunctional chelates, were shown to possess a high level of hyperfixation. A study of biodistribution of these liposomes in rats with Plis lymphosarcoma showed that the level of accumulation of 67Ga-liposomes was enough to obtain a clear scintigraphic tumor image.
Kostenikov
N A
NA
Fadeev
N P
NP
Serzhanina
V A
VA
Korsakova
L N
LN
Rozenberg
O A
OA
D000818:Animals; D005710:Gallium Radioisotopes / Q000008:administration & dosage; D008081:Liposomes; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging*; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D012513:Sarcoma, Experimental / Q000000981:diagnostic imaging*; D013667:Technetium / Q000008:administration & dosage
D005710:Gallium Radioisotopes; D008081:Liposomes; D013667:Technetium
Eksperimental'noe izuchenie tumorotropnykh svoĭstv liposom, mechennykh radionuklidami.