[Cough and bronchial obstruction induced by citric acid in smokers, occasional smokers and non-smokers].
We have studied cough and bronchial constriction induced by inhaling citric acid in 15 smokers with baseline airflow obstruction, in 13 occasional smokers and 13 non smokers. The threshold for cough was significantly higher in occasional smokers in relation to smokers and non smokers. Citric acid produced the same degree of bronchial constriction at the same time in smokers and occasional smokers: the maximum fall in forced expired volume (FEV1-VEMS) was recorded five seconds after inhalation of the citric acid (dose threshold) and there was no significant difference between the two groups. In the non smokers, the maximum fall in VEMS was recorded twenty seconds after inhalation of the citric acid and was significantly less in relation to that of the smokers and occasional smokers. In the smokers the degree of smoking could influence the fall of VEMS (% predicted). Cough and bronchial constriction after the inhalation of citric acid are probably related to different physiological mechanisms and are linked to the history of smoking.
Vlastos
F D
FD
Département des Maladies Respiratoires, Hôpital Universitaire Cochin, Paris.
Dessanges
J F
JF
Lockhart
A
A
Prétet
S
S
D000328:Adult; D000336:Aerosols; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects* / Q000502:physiology; D002951:Citrates / Q000008:administration & dosage; D019343:Citric Acid; D003371:Cough / Q000139:chemically induced*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000503:physiopathology*; D013997:Time Factors
D000336:Aerosols; D002951:Citrates; D019343:Citric Acid
La toux et l'obstruction bronchique induites par l'acide citrique chez les fumeurs, les fumeurs occasionnels et les non-fumeurs.