Anti-AIDS agents, 3. Inhibitory effects of colchicine derivatives on HIV replication in H9 lymphocyte cells.
A series of colchicine and isocolchicine derivatives were evaluated as inhibitors of HIV replication in H9 lymphocytes. Colchicine showed only very slight inhibition in the absence of toxicity, as measured by the therapeutic index (IC50/EC50). None of the derivatives inhibited HIV replication in the absence of toxicity.
Natural Products Laboratory, School of Pharmacy, University of North Carolina 27599.
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H
Tatematsu
R E
RE
Kilkuskie
A J
AJ
Corrigan
A J
AJ
Bodner
K H
KH
Lee
D000998:Antiviral Agents / Q000737:chemistry; D002460:Cell Line; D003078:Colchicine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006801:Humans; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D003078:Colchicine