In vitro susceptibility testing procedures for fosfomycin tromethamine.
Fosfomycin tromethamine (previously fosfomycin trometamol) is an orally administered fosfomycin which may be used for single-dose therapy of uncomplicated urinary tract infections. Fosfomycin tromethamine, norfloxacin, and trimethoprim-sulfamethoxazole inhibited greater than 90% of 352 bacterial isolates representing 25 different species; trimethoprim and nalidixic acid had narrower spectrums of activity. Strains of Escherichia, Citrobacter, Enterobacter, and Klebsiella species were much more susceptible when glucose-6-phosphate was added to the test medium, but isolates belonging to other genera were not affected.
Barry
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AL
Clinical Microbiology Institute, Tualatin, Oregon 97062.
Fuchs
P C
PC
D001419:Bacteria / Q000187:drug effects*; D005578:Fosfomycin / Q000494:pharmacology*; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology; D009643:Norfloxacin / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
D005958:Glucosephosphates; D005578:Fosfomycin; D009268:Nalidixic Acid; D019298:Glucose-6-Phosphate; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D009643:Norfloxacin