[Effects of morphine and electro-acupuncture on the time lock and not-time lock responses of cortical unit discharges evoked by nociceptive stimulation in cats].
In order to study the effects of morphine and electro-acupuncture(EA) on non-time-lock response (N-TLR) and time-lock respone (TLR) of nociceptive unit discharges. N-TLR was shown by interspike interval mean function (ISIMF) and TLR by normalized cross-covariance function (NCCVF) reflecting the relationship between stimulation and response. The results showed that the N-TLR elicited by the noxious stimulation appeared as a decrease of ISIMF. Which was depressed obviously by EA and morphine, but inhibitory effect of EA was more rapid than morphine, that both EA and morphine inhibited mainly the late peak of the NCCVF elicited by the noxious stimulation, but inhibitory effect of EA was more rapidly developing and more quickly recovering than that of morphine. The inhibitory effect of EA on the early peak was very little. From above results it was suggested that the P-ED elicited by the noxious stimulation could be inhibited by both EA and morphine, but the degree and the speed of inhibition were difference.
Department of Physiology, Sun Yat-Sen University of Medical Science, Guangzhou.
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D000818:Animals; D002415:Cats; D015671:Electroacupuncture; D004594:Electrophysiology; D009020:Morphine / Q000494:pharmacology*; D009619:Nociceptors / Q000502:physiology*; D010543:Peroneal Nerve / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D013997:Time Factors
D009020:Morphine