POMC gene expression in mouse and hamster melanoma cells.
Expression of mRNA hybridizable to murine POMC cDNA, and immunoreactivity specific for POMC derived peptide, beta-endorphin, are reported for the first time in one murine and two hamster melanoma lines. The apparent sizes of POMC mRNA transcript were 3.5, 1.5 and 1 kb. It is suggested that POMC gene expression may be involved in the autoregulation of the melanoma phenotype at the cellular and tissue levels.
Slominski
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Department of Immunology and Microbiology, Albany Medical College, NY 12202.
D000818:Animals; D015152:Blotting, Northern; D002460:Cell Line; D006224:Cricetinae; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008546:Melanoma, Experimental / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D008647:Mesocricetus; D051379:Mice; D009368:Neoplasm Transplantation; D011333:Pro-Opiomelanocortin / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000494:pharmacology
D014443:Tyrosine; D007980:Levodopa; D011333:Pro-Opiomelanocortin