[The role of testing DNA adducts and proteins in monitoring cancer risk].
This paper is a review of methods used for determination of adducts of chemicals or their metabolites with DNA of different cells or with blood proteins in humans and animals. Advantages and disadvantages of methods currently used have been discussed. The relationship between adducts formation and genotoxic, mutagenic and carcinogenic properties of chemicals has been shown. An attempt was made to indicate the usefulness of DNA or protein adducts monitoring in humans to detect their exposure to carcinogenic substances and to assess the risk of cancer.
Instytutu Medycyny Pracy, Lodzi.
W
W
Lutz
B
B
Barański
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D002273:Carcinogens; D004273:DNA, Neoplasm / Q000032:analysis*; D004781:Environmental Exposure; D006801:Humans; D008991:Monitoring, Physiologic; D009369:Neoplasms / Q000235:genetics*; D009784:Occupational Diseases / Q000235:genetics*
D014408:Biomarkers, Tumor; D002273:Carcinogens; D004273:DNA, Neoplasm
Znaczenie badania adduktów dna i białek w monitorowaniu zagrozenia choroba nowotworowa.