Improvement in iron deficiency anemia through therapy with ferric ammonium citrate and vitamin C and the effects of aerobic exercise.
In 781 female college students, there were 41 cases of iron deficiency anemia, 209 of latent iron deficiency, 3 of other anemias, and 528 normal cases. Fifty-four volunteers recruited from the iron deficiency anemia and severe latent iron deficiency groups were randomly divided into 4 study groups. Groups I and III received 500 mg of vitamin C daily, and groups II and IV received ferric ammonium citrate (FeAC; equivalent to 6 mg iron) in addition to vitamin C for 9 weeks. Groups I and II were loaded by aerobic exercise at 50% VO2 max. Significant differences between groups were noted in serum ferritin (SF) in III/IV, hematocrit (Ht) in II/III and III/IV, and reticulocytes (RET) in I/II, I/IV, and III/IV. Hemoglobin (Hb) and other iron-related blood indices tended to normalize in groups II and IV when compared with the pre-values. VO2 max was elevated in groups I and II regardless of iron treatment, but was augmented more in group II than group I.
Department of Food and Nutrition, Nakamura Gakuen College, Fukuoka, Japan.
M
M
Taniguchi
H
H
Imamura
T
T
Shirota
H
H
Okamatsu
Y
Y
Fujii
M
M
Toba
F
F
Hashimoto
D000293:Adolescent; D000328:Adult; D000747:Anemia, Hypochromic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D001205:Ascorbic Acid / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D015444:Exercise; D005260:Female; D005290:Ferric Compounds / Q000627:therapeutic use*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000097:blood; D009752:Nutritional Status; D010100:Oxygen / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*
D005290:Ferric Compounds; D006454:Hemoglobins; D000644:Quaternary Ammonium Compounds; D007501:Iron; D001205:Ascorbic Acid; D010100:Oxygen; C013531:ferric ammonium citrate