Antagonism by propyl-beta-carboline-3-carboxylate of passive avoidance impairment induced by diazepam.
We investigated the effects of propyl-beta-carboline-3-carboxylate (beta-CCP) on learning and memory tasks in a passive avoidance test in mice to clarify whether beta-CCP is an agonist or antagonist at benzodiazepine (BZP) receptors. At doses up to 10 mg/kg i.v., beta-CCP had no effect on mice in the passive avoidance test. Diazepam impaired passive avoidance behavior and methyl-beta-carboline-3-carboxylate(beta-CCM) enhanced it. beta-CCP blocked these effects of diazepam and beta-CCM in a dose-dependent manner similar to the effect of Ro15-1788. These effects of beta-CCP, which are thought to be mediated by BZP receptors, indicate that beta-CCP is an antagonist in the passive avoidance test.
Department of Pharmacology, Nobeoka Medicines Laboratory, Asahi Chemical Industry Co., Ltd., Miyazaki, Japan.
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Nagatani
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Yamamoto
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002243:Carbolines / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology*; D003975:Diazepam / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005442:Flumazenil / Q000494:pharmacology; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains
D002243:Carbolines; D003292:Convulsants; D005442:Flumazenil; C028585:propyl beta-carboline-3-carboxylate; D003975:Diazepam