[Immunoregulatory properties of monocytes/macrophages in patients with pulmonary tuberculosis].
Antigen-presenting ability of monocytes/macrophages (Mc/Mph) was studied in 26 patients with pulmonary tuberculosis and in 21 healthy donors. The above investigation has demonstrated that the ability of the Mc/Mph patients to present mycobacterial antigens was not only intact, but also appeared to be even higher than the reference values of Mc/Mph antigen presentation in healthy donors (0.7 and 0.28, respectively). The ability of Mc/Mph to secrete interleukin-1 (IL-1) both spontaneously and as a response to muramil dipeptide, a synthetic macrophage activator, was studied in 24 tuberculosis patients and 15 healthy donors. During the experiment it was revealed that the affected and healthy cells binding to a plastic surface do not differ in their spontaneous production of IL-1 (0.8 and 0.79, respectively). At the same time in response to muramil dipeptide stimulation, the Mc/Mph patients produced lesser IL-1 than those of the healthy donors stimulated under the similar conditions (3.2 +/- 1.1 and 10.6 +/- 3.6, respectively).
G V
GV
Seledtsova
V A
VA
Kozlov
D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000382:microbiology
D000942:Antigens, Bacterial; D007375:Interleukin-1
Immunoreguliatornye svoĭstva monotsitov/makrofagov u bol'nykh tuberkulezom legkikh.