[Protection from gastroduodenal adverse effects of acetylsalicylic acid with ranitidine. An endoscopic controlled double-blind study of healthy subjects].
Ranitidine protects against gastroduodenal mucosal damage associated with low-dose ASA therapy/Endoscopically evaluated double-blind study in healthy volunteers In a randomized double-blind crossover study the gastroduodenal tolerability of 300 mg ASA mane (8 a.m.) has been evaluated in the presence of 300 mg ranitidine nocte (8 p.m.) or placebo in 10 healthy volunteers using upper GI-endoscopy. The treatment periods lasted 14 d. Endoscopic controls were performed at entry, and repeated at day 7 and day 14. At entry the mean endoscopic score averaged 0.9 +/- 0.1 in the ASA/placebo-group and 0.8 +/- 0.1 in the ASA/ranitidine-group. 300 mg ASA mane induced in the placebo-experiments marked gastroduodenal ulcerations both at day 7 and day 14 (7.3 +/- 1.3 and 8.2 +/- 2.1, respectively). Concommittant administration of 300 mg ranitidine nocte afforded almost full protection against 300 mg ASA mane both on day 7 and day 14 (1.6 +/- 0.4 and 1.7 +/- 0.5, respectively) (p less than 0.05). These data suggest that nocturnal coadministration of ranitidine 300 mg reduces almost completely gastroduodenal lesions evoked by acetylsalicylic acid 300 mg mane.
Gastroenterologische Abteilung, Medizinische Universitätsklinik Heidelberg.
P
P
Müller
H G
HG
Dammann
H
H
Bergdolt
B
B
Simon
D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D004311:Double-Blind Method; D016099:Endoscopy, Gastrointestinal; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D011899:Ranitidine / Q000627:therapeutic use*
D011899:Ranitidine; D001241:Aspirin
Verbesserung der gastroduodenalen Verträglichkeit von Azetylsalizylsäure durch Ranitidin. Eine endoskopische kontrollierte Doppelblindstudie an gesunden Probanden.