Carcinogenicity study of cochineal in B6C3F1 mice.
The carcinogenicity of cochineal, a red colouring used in food and other products, was studied in a 2-yr bioassay in B6C3F1 mice. Groups of 50-55 mice of each sex were given 0, 3 or 6% cochineal in the diet for 2 yr. Mice of all groups developed tumours including hepatocellular adenomas or carcinomas, pulmonary adenomas or adenocarcinomas and lymphomas or lymphatic leukaemias, and the incidences of these tumours were not significantly different in treated and control groups. The results indicate that cochineal lacks carcinogenicity in mice and are consistent with those of in vitro short-term assays of cochineal and of carminic acid, an active principle of cochineal.
Department of Pathology, Gifu University School of Medicine, Japan.
H
H
Mori
H
H
Iwata
T
T
Tanaka
Y
Y
Morishita
Y
Y
Mori
T
T
Kojima
A
A
Okumura
D000818:Animals; D002329:Carmine / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D005505:Food Coloring Agents / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced*
D005505:Food Coloring Agents; D002329:Carmine