The prevalence of fragile X in a sample of autistic individuals diagnosed using a standardized interview.
The study examined 75 autistic individuals who met DSM-III-R criteria for autistic disorder at 5 years of age. Diagnosis was based on information elicited using a standardized interview for autism. Two of 75 (2.7%) autistic subjects expressed the fragile X marker (Xq27.3) in 40% of cells counted and had other affected family members. Two additional subjects expressed the fragile X anomaly at low rates (1%). These rates are compared with those reported in other studies. Methodological differences, which may underlie the varying rates reported across studies, are discussed.
Department of Psychiatry, University of Iowa Hospitals and Clinics.
J
J
Piven
J
J
Gayle
R
R
Landa
M
M
Wzorek
S
S
Folstein
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D015142:Baltimore / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005600:Fragile X Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D006801:Humans; D015994:Incidence; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D010552:Personality Assessment