Effects of fibric acid derivatives on accumulation of actin in myocardiocytes.
We used sodium dodecylsulphate polyacrylamide gel electrophoresis and immunoblotting to analyze the effects of the fibric acid derivatives bezafibrate, fenofibrate and gemfibrozil on the accumulation of actin in the cytoplasmic and cytoskeletal fraction of cultured myocardiocytes. All three drugs tested modified cellular and subcellular actin in different ways, and the findings are thought to be related with the secondary effect of arrhythmia known to be caused by these drugs. Bezafibrate and gemfibrozil more markedly affected accumulation of actin by myocytes, while fenofibrate interfered less notably with the accumulation of this protein.
Aránega
A
A
Basic Cardiovascular Research Section, School of Medicine, University of Granada, Spain.
González
F J
FJ
Aránega
A E
AE
Muros
M A
MA
Fernández
J E
JE
Vélez
C
C
Prados
J
J
Alvarez
L
L
D000199:Actins / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001629:Bezafibrate / Q000494:pharmacology*; D002478:Cells, Cultured; D002642:Chick Embryo; D003599:Cytoskeleton / Q000187:drug effects; D004591:Electrophoresis, Polyacrylamide Gel; D011345:Fenofibrate / Q000494:pharmacology*; D015248:Gemfibrozil / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D015151:Immunoblotting; D009206:Myocardium / Q000166:cytology*
D000199:Actins; D015248:Gemfibrozil; D011345:Fenofibrate; D001629:Bezafibrate