Effect of the 8-aminoquinoline primaquine on culture-derived gametocytes of the malaria parasite Plasmodium falciparum.
Gametocytes from the Honduras I/CDC clone HB-3 of Plasmodium falciparum were exposed to different concentrations of primaquine diphosphate. It could be shown that the drug acts specifically on the mitochondria of the cells by destroying their internal structure and causing these organelles to swell.
Lanners
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Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University Medical Center, New Orleans, LA 70112.
D000818:Animals; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000648:ultrastructure; D011319:Primaquine / Q000494:pharmacology*
D011319:Primaquine