Hem-1, a potential membrane protein, with expression restricted to blood cells.
Overlapping cDNAs 3.8 kb in length containing a long open reading frame were obtained that hybridized exclusively to transcripts from hematopoietic cells. Sequence analysis found eight potential membrane domains and two possible cAMP/cGMP phosphorylation sites. This sequence exhibited no homologies with the EMBL/Genbank nucleic acid, SwissProt or GenPept amino acid data bases. The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A.
Hromas
R
R
Department of Medicine IB-442, Indiana University Medical Center, Indianapolis 46202-5121.
Collins
S
S
Raskind
W
W
Deaven
L
L
Kaushansky
K
K
D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000235:genetics*; D015347:RNA Probes
D008565:Membrane Proteins; D010750:Phosphoproteins; D015347:RNA Probes; D004247:DNA