Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.
Cryptosporidicidal effects of two polyether ionophores (maduramicin and alborixin), a fluorinated 4-quinolone (enrofloxacin), and three analogs of pentamidine were evaluated in a suckling mouse bioassay. Treatment with all compounds except enrofloxacin and one of the pentamidine analogs [1,3-di(4-imidazolinophenoxy)propane] resulted in significant (P less than 0.05) reductions in oocyst excretion.
Blagburn
B L
BL
Department of Pathobiology, College of Veterinary Medicine, Auburn University, Alabama 36849-5519.
Sundermann
C A
CA
Lindsay
D S
DS
Hall
J E
JE
Tidwell
R R
RR
D042462:4-Quinolones; D000578:Amidines / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D000833:Animals, Suckling; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D003458:Cryptosporidium / Q000187:drug effects*; D000077422:Enrofloxacin; D004987:Ethers / Q000009:adverse effects / Q000494:pharmacology*; D024841:Fluoroquinolones; D007476:Ionophores / Q000494:pharmacology; D007783:Lactones / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D010419:Pentamidine / Q000031:analogs & derivatives / Q000494:pharmacology; D011714:Pyrans / Q000494:pharmacology; D015363:Quinolones
D042462:4-Quinolones; D000578:Amidines; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004987:Ethers; D024841:Fluoroquinolones; D007476:Ionophores; D007783:Lactones; D011714:Pyrans; D015363:Quinolones; C012708:alborixin; D000077422:Enrofloxacin; C018091:maduramicin; D010419:Pentamidine