Administration of carbamazepine in the nucleus of the solitary tract inhibits the antihypertensive effect of clonidine.
The effects of carbamazepine administration into the nucleus tractus solitarii (NTS) on central alpha 2-adrenergic cardiovascular function were studied in normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR). Stereotaxic microinjections of carbamazepine (288 ng/60 nl) into the NTS of SHR transiently increased blood pressure, heart rate, and renal sympathetic nerve activity. These effects were followed by a modest depressor and bradycardic effect, with no change in sympathetic nerve activity. In addition, previous intra-NTS administration of carbamazepine attenuated the antihypertensive effect of the centrally acting alpha 2-adrenoceptor agonist, clonidine. Similar carbamazepine effects were observed in the WKY rats. These results suggest that some of the cardiovascular changes observed during carbamazepine treatment involve antagonism of central noradrenergic mechanisms.
Department of Medicine, Vanderbilt University, Nashville TN 37232.
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Mosqueda-Garcia
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JA
Oates
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Appalsamy
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D
Robertson
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002220:Carbamazepine / Q000008:administration & dosage* / Q000633:toxicity; D003000:Clonidine / Q000037:antagonists & inhibitors*; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D002220:Carbamazepine; D003000:Clonidine