Correction of cerebrospinal fluid copper in Menkes kinky hair disease.
A patient with Menkes Kinky Hair disease was treated with infusions of copper-histidine which resulted in normal copper values in the cerebrospinal fluid. This tends to confirm the in vitro data that copper is transported into the central nervous system complexed with histidine or other similar ligands.
Department of Pediatrics, University of Michigan Medical Center, Ann Arbor.
P R
PR
Kollros
R D
RD
Dick
G J
GJ
Brewer
D001803:Blood Transfusion; D002570:Ceruloplasmin / Q000032:analysis; D003300:Copper / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid*; D006639:Histidine / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D007706:Menkes Kinky Hair Syndrome / Q000134:cerebrospinal fluid*; D010949:Plasma
D006639:Histidine; D003300:Copper; D002570:Ceruloplasmin