Morphological analysis of hair in the hr-2 mutant deer mouse (Peromyscus maniculatus).
Skin from 36 hairless deer mice (Peromyscus maniculatus) homozygous for the recessive hr-2 mutation were analyzed for structural defects in hair and hair loss. Comparison of mutant to wild-type hairs demonstrated characteristic abnormalities in cellular organization, hair shape, length, and fragility. Matings between mutants homozygous for the hr-2 gene and for a second mutation producing hairlessness in deer mice, hr-1, showed that these two genes were nonallelic. Structural abnormalities in hairs associated with the expression of this gene suggest that its primary effect may be on the epidermis.
Knapp
L W
LW
Department of Biological Sciences, University of South Carolina, Columbia 29208.
Dawson
W D
WD
D000505:Alopecia / Q000235:genetics / Q000662:veterinary; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D006197:Hair / Q000254:growth & development / Q000648:ultrastructure*; D008297:Male; D009154:Mutation; D010542:Peromyscus / Q000235:genetics*