Determination of sultopride and tiapride in serum by gas chromatography using a surface ionisation detector.
A sensitive and selective method has been developed for the determination of sultopride and tiapride in serum using gas chromatography with a surface ionisation detector. No interfering peaks from endogenous substances were observed. The method showed good reproducibility and accuracy, and the standard curve was linear up to 2 micrograms/ml with a correlation coefficient of 0.999. This method is applicable to pharmacokinetic studies and therapeutic drug monitoring of sultopride and tiapride.
Department of Pharmaceutical Services, Kumamoto University Hospital, Japan.
A
A
Kamizono
N
N
Inotsume
K
K
Miyamoto
K
K
Ueda
T
T
Miyakawa
H
H
Arimoto
M
M
Nakano
D000077582:Amisulpride; D002849:Chromatography, Gas; D006801:Humans; D007477:Ions; D008297:Male; D011619:Psychotropic Drugs / Q000097:blood*; D011863:Radioimmunoassay; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000097:blood; D013976:Tiapamil Hydrochloride / Q000097:blood*
D007477:Ions; D011619:Psychotropic Drugs; D013469:Sulpiride; D000077582:Amisulpride; D013976:Tiapamil Hydrochloride