[Etiology of multiple sclerosis].
The risk of developing Multiple Sclerosis is under the combined influence of environmental and endogenous factors, as shown by epidemiological and genetic studies. Immunological abnormalities are a salient feature of the disease but their myelinotoxic effect is still to be demonstrated. The pathogenesis of the disease remains unknown. The auto-immune theory as well as the infectious theory are arguable but they may, also, be both valid. Multiple sclerosis could be a post-infectious auto-immune disease, "final common way" of common childhood infections. Anyway, no infectious agent is demonstrable inside the central nervous system at the overt disease stage.
Confavreux
C
C
Clinique de neurologie, hôpital neurologique, Lyon.
Goudable
B
B
Moreau
T
T
D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D012307:Risk Factors
Etiologie de la sclérose en plaques.