Pharmacokinetics of ceftriaxone.
Ceftriaxone fulfills many of the qualities of an ideal antibiotic: a prolonged elimination half-life, which results from a "restrictive" excretion pattern; saturable protein binding, which provides the theoretical basis for administering the total daily dose as a single bolus; and once-a-day dosing, which provides plasma and tissue concentrations that exceed the MIC for most susceptible pathogens for 24 hours.
Blumer
J
J
Case Western Reserve University.
D001424:Bacterial Infections / Q000188:drug therapy / Q000378:metabolism; D002443:Ceftriaxone / Q000378:metabolism / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D011485:Protein Binding
D002443:Ceftriaxone