[The absence of a parallelism between the antihypoxic and anti-ischemic actions of pharmacological agents].
The experiments on different species of animals (mice, cats) showed the lack of parallelism between the antihypoxic and anti-ischemic effects of pharmacological agents. Of four studied antihypoxic agents (lithium oxybutyrate, piracetam, glyo-6, a derivative of pyrimidine S-207) only GABA derivatives showed an increase of the lactate/pyruvate ratio in the blood of the venous sinus under occlusion of the coronary artery and consequently possessed the anti-ischemic properties. Such difference in the effects of the antihypoxic agents on the myocardium was determined to a certain degree by their different influences on the collateral coronary blood circulation.
Lomtadze
D M
DM
Tsorin
I B
IB
Chirkova
E Iu
EIu
Chichkanov
G G
GG
D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D051379:Mice; D013329:Structure-Activity Relationship; D013997:Time Factors
D002317:Cardiovascular Agents
Otsutstvie parallelizma mezhdu antigipoksicheskim i protivoishemicheskim deĭstviem farmakologicheskikh sredstv.