Intracytoplasmic lumina--a useful diagnostic feature of adenocarcinomas.
The monoclonal antibody NCRC-11, which has epithelial membrane antigen (EMA)-like immunoreactivity, was used to identify intracytoplasmic lumina in a series of 105 adenocarcinomas from various sites and in 283 breast carcinomas; 55% of the non-breast carcinomas and all breast carcinomas except one of spindle cell type contained intracytoplasmic lumina. The highest frequency (16.4% of tumour cells) was found in invasive lobular carcinoma of the breast. The use of antibodies with EMA reactivity is advocated in the routine investigation of metastatic and undifferentiated tumours.
Quincey
C
C
Department of Histopathology, City Hospital, Nottingham, UK.
Raitt
N
N
Bell
J
J
Ellis
I O
IO
D000230:Adenocarcinoma / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D003593:Cytoplasm / Q000276:immunology / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000276:immunology; D018396:Mucin-1
D000911:Antibodies, Monoclonal; D008562:Membrane Glycoproteins; D018396:Mucin-1