Adult-onset Still's disease: hepatic involvement and various serum markers relating to the disease activity.
A 53-year-old woman was admitted to our hospital due to high fever, arthralgia and skin rash. Main laboratory data included the following: WBC 17,100/mm, GOT 58 U, GPT 47 U, LDH 1,510 U, ferritin 19,000 ng/ml, adenosine deaminase 79.1 U/l. She was diagnosed as having adult-onset Still's disease. Aspirin (3.0 g/day) and prednisolone (40 mg/day) were administered. All the symptoms and laboratory data improved rapidly. Adenosine deaminase, ferritin, and LDH are considered to originate mainly from the liver. Liver injury in this disease may be a primary lesion, and various serum markers may be associated with the liver abnormalities.
Department of Internal Medicine, Cancer Research Institute, Kanazawa University, Japan.
Y
Y
Motoo
H
H
Ohta
T
T
Okai
N
N
Sawabu
D000243:Adenosine Deaminase / Q000097:blood*; D001241:Aspirin / Q000627:therapeutic use; D015415:Biomarkers; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D004890:Erythema / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005293:Ferritins / Q000032:analysis*; D005334:Fever / Q000175:diagnosis*; D006801:Humans; D007239:Infections / Q000175:diagnosis; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis; D011239:Prednisolone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D016706:Still's Disease, Adult-Onset / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
D015415:Biomarkers; D007527:Isoenzymes; D005293:Ferritins; D011239:Prednisolone; D007770:L-Lactate Dehydrogenase; D000243:Adenosine Deaminase; D001241:Aspirin