Renal damage in mice after sequential cisplatin and irradiation: the influence of prior irradiation on platinum elimination.
Doses of 4-6 mg kg-1 c-DDP given 6 months before renal irradiation caused only a modest increase in functional radiation damage (DEF 1.1). These effects could be explained by additive toxicities and the damage was much less than when c-DDP was given 3-6 months after irradiation. Pharmacokinetic studies did not demonstrate any decrease in the rate of platinum elimination after previous low-dose renal irradiation.
Division of Experimental Therapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoekhuis, Amsterdam.
F A
FA
Stewart
H
H
Bartelink
G B
GB
van der Voet
F A
FA
de Wolff
D000818:Animals; D002945:Cisplatin / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000528:radiation effects*; D051379:Mice; D008809:Mice, Inbred C3H; D010984:Platinum / Q000378:metabolism* / Q000493:pharmacokinetics; D011833:Radiation Injuries, Experimental
C034297:diamminediaqua platinum(II); D010984:Platinum; D002945:Cisplatin