19F NMR imaging of cerebral blood flow.
Techniques for the quantitative imaging assessment of cerebral blood flow are presented in a cat using 19F NMR imaging of trifluoromethane. The input function of the indicator was acquired noninvasively, while its uptake and clearance were followed in 2-cc volume voxels from images acquired at 67 s intervals. A single compartment model yielded normal cerebral blood flow estimates.
Branch
C A
CA
NIH Center for Stroke Research, Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202.
Helpern
J A
JA
Ewing
J R
JR
Welch
K M
KM
D000818:Animals; D001812:Blood-Brain Barrier; D002415:Cats; D002560:Cerebrovascular Circulation; D005617:Chlorofluorocarbons, Methane / Q000493:pharmacokinetics; D005461:Fluorine; D007091:Image Processing, Computer-Assisted; D007201:Indicator Dilution Techniques; D009682:Magnetic Resonance Spectroscopy; D013990:Tidal Volume
D005617:Chlorofluorocarbons, Methane; D005461:Fluorine; C009554:fluoroform