[Therapeutic possibilities in the management of antitrypsin-deficient pulmonary emphysema].
Congenital alpha-1-antitrypsin deficiency may lead to pulmonary emphysema in young adults. Authors review the therapeutic approaches of this disease. Attempts to augment the production of endogenous antitrypsin are discussed in detail. Possibilities of substitution by human alpha-1-antitrypsin and recombinant alpha-1-antitrypsin are summarized. Results with the use of specific elastase inhibitors as well as the role and the site of gen-therapy in treatment are reviewed.
Semmelweis Orvostudományi Egyetem, Budapest, Pulmonológiai Klinika.
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Tarján
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Pitlik
D015316:Genetic Therapy; D006801:Humans; D008661:Metabolism, Inborn Errors / Q000235:genetics; D011656:Pulmonary Emphysema / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D000515:alpha 1-Antitrypsin / Q000008:administration & dosage / Q000096:biosynthesis / Q000235:genetics; D019896:alpha 1-Antitrypsin Deficiency
D000515:alpha 1-Antitrypsin
Terápiás lehetöségek az antitripszin hiányos pulmonális emphysema kezelésében.