Human milk containing specific secretory IgA inhibits binding of Giardia lamblia to nylon and glass surfaces.
The effects of human milk, containing specific secretory IgA, on the adherence of Giardia lamblia trophozoites in the presence and in the absence of intestinal mucus in vitro were studied. It was found that the trophozoites treated with breast milk, containing specific secretory IgA to G. lamblia, showed a significant decrease (p less than 0.01) in adherence to nylon fibre columns and glass surfaces than did trophozoites treated with milk containing no SIgA antibodies. The adherence to glass surfaces was significantly more (p less than 0.01) in the presence of intestinal mucus than when the mucus was absent. Milk that did not contain specific secretory SIgA to G. lamblia did not decrease the adherence to glass surfaces either in the presence or in the absence of mucus. The fluorescence study revealed the binding of specific secretory IgA on the trophozoite surface. The results suggest that binding of SIgA antibodies in milk to G. lamblia trophozoites inhibits parasite adherence, thus protecting against this infection in breast-fed babies.
Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
H K
HK
Samra
N K
NK
Ganguly
R C
RC
Mahajan
D000818:Animals; D002448:Cell Adhesion; D016829:Giardia lamblia / Q000276:immunology*; D005898:Glass; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000276:immunology*; D008895:Milk, Human / Q000276:immunology*; D009757:Nylons
D007071:Immunoglobulin A, Secretory; D009757:Nylons