Detection of subacute infectious foci with indium-111-labeled autologous leukocytes and indium-111-labeled human nonspecific immunoglobulin G: a prospective comparative study.
In 35 patients suspected of an infectious focus, the outcome of scintigraphy with 111In-labeled autologous leukocytes (WBC) and 111In-labeled human nonspecific immunoglobulin G (IgG) was evaluated in a prospective comparative study. Clinical, roentgenologic and microbiologic findings were considered to be proof of the presence of infection or inflammation. In this group of patients with mainly subacute infections, 111In-IgG scintigraphy performed significantly better than 111In-WBC scintigraphy, especially in infections of the locomotor system, but also in various soft-tissue infections. Both techniques showed disappointing results in patients with disseminated yersinia infection and in some patients with tuberculosis. Overall sensitivity and specificity was 74% and 100% for 111In-IgG scintigraphy and 52% and 78% for 111In-WBC scintigraphy, respectively.
Department of Nuclear Medicine, University Hospital Nijmegen, The Netherlands.
W J
WJ
Oyen
R A
RA
Claessens
J W
JW
van der Meer
F H
FH
Corstens
D001424:Bacterial Infections / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D005490:Focal Infection / Q000000981:diagnostic imaging* / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D007205:Indium Radioisotopes; D007553:Isotope Labeling; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D007205:Indium Radioisotopes