LV-arterial coupling: interactive model to predict effect of wave reflections on LV energetics.
The interaction between the left ventricle (LV) and the arterial system was simulated using sequential convolution of the flow output generated by a time-varying elastance model of the LV with an impulse response calculated from a 128-element model of the arterial system. The model illustrates the effect of independent changes of components of the arterial load on LV performance and energetics. This report studies the response of the model LV to an increase in arterial resistance, a decrease in arterial compliance, and an increase in discrete vascular reflections. Although arterial resistance exerts the greatest effect on ventricular stroke output, a reduction of arterial compliance or an increase in early reflections resulted in less optimal coupling of the heart to the arteries and less efficient energy utilization by the LV. In addition, the earlier the reflections return, the greater the disturbance of ventricular arterial coupling.
Division of Cardiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
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Fitchett
D000375:Aging / Q000502:physiology; D001158:Arteries; D001794:Blood Pressure; D001810:Blood Volume; D003331:Coronary Vessels / Q000502:physiology*; D004548:Elasticity; D005544:Forecasting; D006801:Humans; D008955:Models, Cardiovascular; D014655:Vascular Resistance; D016277:Ventricular Function, Left