Mapping the mouse craniofacial mutation first arch (Far) to chromosome 2.
First arch (Far) is a semidominant mutation that causes severe craniofacial defects in mice. Here we report the results of linkage studies with the chromosome 2 markers nonagouti, pallid, and Ulnaless. Far is loosely linked to nonagouti (24-37 cM), more closely linked to pallid (13-28 cM), and closely linked to Ulnaless (2.3 +/- 1.5 cM). The embryological defect in Far mutants is confined to one segmentally-derived region of the head, the anterior first branchial arch. It may therefore be significant that, in mapping near Ulnaless, Far also maps in the vicinity of the Hox-4 gene cluster.
Department of Medical Genetics, University of British Columbia, Vancouver, B.C. Canada.
D M
DM
Juriloff
M J
MJ
Harris
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005147:Facial Bones / Q000002:abnormalities*; D005260:Female; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D008817:Mice, Mutant Strains / Q000235:genetics*; D012886:Skull / Q000002:abnormalities*; D013577:Syndrome