Identification of an inhibitor of microtubule assembly present in juvenile brain which displays a novel mechanism of action involving suppression of self-nucleation.
An inhibitor of microtubule assembly has been identified and partially purified from microtubule-depleted brain extracts from day-old chicks and 4-month-old calf. This inhibitor suppresses the self-nucleation of microtubules in vitro with minimal effect upon the final extent of assembly. It may have a developmental role in vivo as it is not detected in adult brain from either cattle or rabbit.
Surridge
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CD
Biophysics Section, Blackett Laboratory, Imperial College of Science, Technology and Medicine, London, U.K.
Burns
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RG
D000645:Ammonium Sulfate; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000648:ultrastructure*; D001923:Brain Chemistry; D002417:Cattle; D011232:Chemical Precipitation; D002645:Chickens; D007700:Kinetics; D008868:Microtubule Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008870:Microtubules / Q000502:physiology* / Q000648:ultrastructure
D008868:Microtubule Proteins; D000645:Ammonium Sulfate