Chromosomal assignment of the human immunophilin FKBP-12 gene.
FKBP-12 is the major T cell binding protein for the immunosuppressive drugs FK506 and rapamycin. It is a member of the immunophilin family of proteins which are believed to play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The chromosomal assignment of the human FKBP-12 gene was determined by using the polymerase chain reaction to amplify an intron-containing region of the gene in purified DNA isolated from 42 human-rodent somatic cell hybrids. The results of this analysis indicated that the FKBP-12 gene resides on human chromosome 20.
DiLella
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AG
Department of Molecular Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406.
D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002460:Cell Line; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20; D005091:Exons; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D007166:Immunosuppressive Agents / Q000378:metabolism; D007438:Introns; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping; D013601:T-Lymphocytes / Q000502:physiology; D022021:Tacrolimus Binding Proteins
D002352:Carrier Proteins; D007166:Immunosuppressive Agents; D009838:Oligodeoxyribonucleotides; D022021:Tacrolimus Binding Proteins