[Macrophage activity during high dose steroid pulse therapy and 7S-immunoglobulin administration in patients with collagenoses. Comparison with in vitro studies].
Patients with connective tissue diseases show increased neopterin levels indicating the activation of the monocyte system. Corticosteroids reduce the release of neopterin in vivo and in vitro. After i.v. 7S-Ig administration neopterin increases in vivo transiently and decreases beyond the pretherapeutic levels. Addition of 7S-Ig to cell cultures reduces the macrophage activation.
Städtisches Krankenhaus München-Bogenhausen, Akademisches Lehrkrankenhaus der TU München.
H
H
Zmierczak
J
J
Teuber
R
R
Wiest
H J
HJ
Hatz
K
K
Helmke
D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000628:therapy; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism; D002478:Cells, Cultured; D003095:Collagen Diseases / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007116:Immunization, Passive; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000628:therapy; D008262:Macrophage Activation / Q000187:drug effects* / Q000276:immunology; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009000:Monocytes / Q000276:immunology; D019798:Neopterin; D014657:Vasculitis / Q000276:immunology / Q000628:therapy
D001708:Biopterins; D019798:Neopterin; D008775:Methylprednisolone
Makrophagenaktivität unter hochdosierter Steroid-Stosstherapie und 7S-Immunglobulingabe bei Patienten mit Kollagenosen. Vergleich mit In-vitro-Untersuchungen.