Primary leiomyosarcoma of bone.
Four cases of primary leiomyosarcoma of bone are presented. The histology of this rare tumour has been studied with a panel of monoclonal antibodies to the intermediate filaments desmin and vimentin, and to other markers including smooth muscle actin, myosin, alpha 1-antitrypsin, alpha 1-antichymotrypsin, lysozyme, S-100 protein and cytokeratin. The tumour cells were uniformly positive for desmin, vimentin, and in one case for smooth muscle actin; all the other markers were negative. The findings have been compared with other spindle cell lesions of bone and with electron-microscopy of the tumours. Immunohistochemistry allows the histological diagnosis to be made without the need to resort to ultrastructural studies.
Department of Pathology, University College and Middlesex School of Medicine, London, UK.
M P
MP
Young
A J
AJ
Freemont
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001859:Bone Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers