[Nitroglycerin reduces requirement of pancuronium in surgical patients].
We performed a study on 34 adult surgical patients between 15 and 56 years of age, to evaluate whether synergism between nitroglycerin and pancuronium exists or not. Neuromuscular (NM) transmission was measured by electromyography of the thenar muscle using transcutaneous electrodes. Anesthesia was induced by droperidol 0.2 mg.kg-1, fentanyl 50 micrograms, thiamylal 150-250 mg, and succinylcholine 1 mg.kg-1, and maintained with nitrous oxide and O2 (67:33) supplemented with repeated i.v. doses of fentanyl (within 15 micrograms.kg-1). Pancuronium 4 mg was given at the 20% recovery from succinylcholine induced NM block. Sequential i.v. doses of pancuronium 1 mg were injected repeatedly at the every 20% recovery until the end of operation. To control blood pressure, nitroglycerin, ranging from 0 to 5 micrograms.kg-1.min-1, was given intravenously. The linear multiple regression analysis was performed between the dose of pancuronium (micrograms.kg-1.hr-1) and the dose of nitroglycerin (micrograms.kg-1.min-1), the age, sex, or body weight of the patients. The results show that the dose of pancuronium decreases with increasing dose of nitroglycerin. No relationship was found between the dose of pancuronium and the age, sex, or body weight of the patients. In conclusion, nitroglycerin reduces requirement of pancuronium in surgical patients.
Koyama
T
T
Department of Anesthesiology, Jikei University School of Medicine, Tokyo.
Amaki
Y
Y
Kobayashi
K
K
D000293:Adolescent; D000328:Adult; D004357:Drug Synergism; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects*; D005996:Nitroglycerin / Q000008:administration & dosage*; D010197:Pancuronium / Q000008:administration & dosage*; D013514:Surgical Procedures, Operative
D005996:Nitroglycerin; D010197:Pancuronium