Effects of macrophage colony-stimulating factor on reduction of viable bacteria and survival of mice during Listeria monocytogenes infection: characteristics of monocyte subpopulations.
Mice could well tolerate infection with a lethal dose of Listeria monocytogenes after intraperitoneal preinjections with 250 micrograms of macrophage colony-stimulating factor (M-CSF) per kg of body weight for 5 days. The characteristic changes in the surface markers (Mac-1, LFA-1, and F4/80) of peripheral monocytes were also investigated in order to analyze the mechanism of protection by M-CSF. This investigation shows the excellent effect of intraperitoneal preinjections of M-CSF on the reduction of viable Listeria organisms and the improvement of survival after an intravenous Listeria infection.
Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
S
S
Kayashima
S
S
Tsuru
N
N
Shinomiya
Y
Y
Katsura
K
K
Motoyoshi
M
M
Rokutanda
N
N
Nagata
D000818:Animals; D005260:Female; D007958:Leukocyte Count; D008089:Listeria monocytogenes / Q000187:drug effects*; D008088:Listeriosis / Q000276:immunology* / Q000382:microbiology / Q000401:mortality; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology
D016173:Macrophage Colony-Stimulating Factor