Plurihormonal adenomas. Analysis of 62 cases.
This paper deals with the cytological features of pituitary plurihormonal adenomas based on 62 cases examined by histology, immunohistochemistry, ultrastructural study and post-embedding immunogold electron microscopy, including double labeling. In GH-cell containing adenomas, there were 9 adenomas consisting of exclusively GH and PRL cells. The other 39 adenomas contained other hormones as well as GH and PRL. Other nine combinations of pituitary hormones or alpha-subunit were observed. Special emphasis was laid on the fact that a greater part of GH-producing adenomas (74% by immunostain) were PRL-producing, although the ratio of GH-cells to PRL-cells widely varied from case to case. Concerning the double labeling study on mixed GH-PRL secreting adenomas, we recognized the existence of secretory granules containing GH only, those containing PRL only, those containing both GH and PRL and those containing neither.
Kameya
T
T
Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Furuhata
S
S
D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D006046:Gold; D013006:Growth Hormone / Q000378:metabolism; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007158:Immunologic Techniques; D008854:Microscopy, Electron; D011388:Prolactin / Q000378:metabolism
D006728:Hormones; D006046:Gold; D011388:Prolactin; D013006:Growth Hormone