Human alpha-calcitonin gene-related peptide (CGRP)-(8-37), but not -(28-37), inhibits carotid vasodilator effects of human alpha-CGRP in vivo.
Human alpha-calcitonin gene-related peptide-(8-37) alone (up to doses of 30 nmol kg-1 min-1) had no significant effects on blood pressure, heart rate or common or internal carotid haemodynamics, although it caused significant, reversible, inhibition of the hypotensive, tachycardic, and common and internal carotid vasodilator effects of human alpha-CGRP (0.03 nmol kg-1 min-1) in conscious, Long Evans rats. Human alpha-CGRP-(28-37) up to doses of 300 nmol kg-1 min-1 had no cardiovascular effects itself and did not influence responses to human alpha-CGRP. These results are consistent with the carotid haemodynamic effects of human alpha-CGRP being due largely to activation of the CGRP1-receptor subtype.
Department of Physiology and Pharmacology, Queen's Medical Centre, Nottingham, U.K.
S M
SM
Gardiner
A M
AM
Compton
P A
PA
Kemp
T
T
Bennett
C
C
Bose
R
R
Foulkes
B
B
Hughes
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D002343:Carotid Artery, Internal / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D014665:Vasodilator Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D010446:Peptide Fragments; D014665:Vasodilator Agents; C071243:calcitonin gene-related peptide (28-37); C058636:calcitonin gene-related peptide (8-37); D015740:Calcitonin Gene-Related Peptide