Anabolic/androgenic steroid abuse and thrombosis: is there a connection?
Anabolic/androgenic steroid abuse is an increasing medical and public health problem. The uncontrolled use of these agents has been associated with numerous toxic side-effects including deleterious cardiovascular changes. The most widely reported to these latter changes include the development of adverse lipid profiles and hypertension. Acute thrombosis has only recently been linked to androgen abuse. Such a causative link has been proposed in reports of acute myocardial infarction and stroke in several athletes using androgens. Unfortunately, there exists no direct evidence that androgens are thrombogenic in humans. However, indirect experimental data suggests that androgens affect platelet aggregation, coagulation proteins and the vascular system in ways that facilitate thrombosis. Androgens also increase several anticoagulant and fibrinolytic proteins. However, they have not been shown to protect from thrombosis in high risk patients. Existing data supports a possible thrombogenic effect of exogenous androgens. Further studies are needed to clarify the hemostatic influence associated with androgen abuse in weightlifters. The abuse of these agents may diminish if acute thrombosis becomes clearly and scientifically associated with their uncontrolled use.
Michigan State University, E. Lansing 48824-1319.
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D045930:Anabolic Agents / Q000009:adverse effects*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D004300:Doping in Sports; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D008955:Models, Cardiovascular; D045165:Testosterone Congeners / Q000009:adverse effects*; D013927:Thrombosis / Q000139:chemically induced*
D045930:Anabolic Agents; D045165:Testosterone Congeners