Nonsecretion of myeloma protein in spite of an increase in tumor burden by chemotherapy.
A unique case of IgA kappa myeloma is presented. While the myeloma cells had secreted a large quantity of IgA kappa monoclonal protein, they were induced to stop secreting the monoclonal protein by cyclophosphamide and vincristine, in spite of a remarkable increase in tumor burden. The absence of intracytoplasmic IgA kappa was clearly evidenced by the immunofluorescence technique using anti-IgA and anti-kappa monoclonal antibodies.
Department of Medicine, Kusatsu Branch Hospital, Gunma University School of Medicine, Japan.
K
K
Kubota
H
H
Kurabayashi
E
E
Kawada
K
K
Okamoto
J
J
Tamura
T
T
Shirakura
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002699:Chlorambucil / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000378:metabolism*; D009194:Myeloma Proteins / Q000096:biosynthesis*; D014750:Vincristine / Q000008:administration & dosage
D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains; D009194:Myeloma Proteins; D002699:Chlorambucil; D014750:Vincristine; D003520:Cyclophosphamide