Astemizole-induced cardiac conduction disturbances in a child.
The newly available antihistamine astemizole (Hismanal) has been previously associated with hemodynamically significant cardiac tachydysrhythmias. We describe a 3-year-old girl who developed multiple different cardiac dysrhythmias after an astemizole overdose. No hemodynamic compromise occurred, and the electrocardiogram returned to normal without use of antiarrhythmic agents within 7 hours.
Tobin
J R
JR
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205.
Doyle
T P
TP
Ackerman
A D
AD
Brenner
J I
JI
D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000503:physiopathology; D016589:Astemizole / Q000506:poisoning*; D062787:Drug Overdose; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D007223:Infant
D016589:Astemizole