Comparative efficacy of chlorophyllin in reducing cytotoxicity of some heavy metals.
The potential of chlorophyllin in reducing clastogenicity was studied against two concentrations of each of three potent metallic clastogens (cesium chloride, mercuric chloride and cobalt chloride) in bone marrow cells of mice in vivo. The respective salts and chlorophyllin were administered orally to mice by gavaging in different combinations. Simultaneous administration of chlorophyllin with both concentrations of each salt reduced the clastogenic effects in the order Cs greater than Hg greater than Co. Chlorophyllin could not decrease the clastogenic effects when administered 2 h before the salts.
Department of Botany, Calcutta University, India.
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Ghosh
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Sen
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Palit
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Ghosh
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Sharma
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Talukder
D000818:Animals; D002586:Cesium / Q000037:antagonists & inhibitors / Q000633:toxicity; D002712:Chlorides; D002735:Chlorophyllides / Q000494:pharmacology*; D002869:Chromosome Aberrations; D003035:Cobalt / Q000037:antagonists & inhibitors / Q000633:toxicity; D008627:Mercuric Chloride / Q000037:antagonists & inhibitors / Q000633:toxicity; D008670:Metals / Q000037:antagonists & inhibitors* / Q000633:toxicity; D051379:Mice; D009152:Mutagenicity Tests
D002712:Chlorides; D002735:Chlorophyllides; D008670:Metals; D002586:Cesium; D003035:Cobalt; D008627:Mercuric Chloride; C007020:chlorophyllin; C018021:cobaltous chloride; C028019:cesium chloride