Naloxone reversal of hypotension due to captopril overdose.
The hemodynamic effects of captopril and other angiotensin-converting enzyme inhibitors may be mediated by the endogenous opioid system. The opioid antagonist naloxone has been shown to block or reverse the hypotensive actions of captopril. We report a case of an intentional captopril overdose, manifested by marked hypotension, that resolved promptly with the administration of naloxone. To our knowledge, this is the first reported case of captopril-induced hypotension treated with naloxone. Our experience demonstrates a possible role of naloxone in the reversal of hypotension resulting from captopril.
Department of Medicine, Stanford University Medical Center, California.
J
J
Varon
S R
SR
Duncan
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000037:antagonists & inhibitors / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000188:drug therapy; D009270:Naloxone / Q000627:therapeutic use*; D013406:Suicide, Attempted
D009270:Naloxone; D002216:Captopril