[The liver in the pathogenesis of multiple organ failure].
Our previous experimental studies showed that the liver is firstly and most severely involved in metabolic damage among various organs after hypoperfusion and sepsis. Changes of metabolites in liver and other organs as well as the function of circulating leukocytes were measured in three rat models with liver ischemia, or systemic hypoperfusion and sepsis. Partial liver ischemia 120 minutes after reperfusion not only resulted in significant decline of ATP and GSH levels in ischemic liver lobes but also in metabolic disorders in non-ischemic liver lobes, kidney, and small intestine. The amount of circulating white blood cells and zymosan stimulated chemoluminescence was increased. The findings showed that ischemic injury in partial liver may accelerate the whole liver damage and aggravate the metabolic disorders in other organs as well as the deterioration of homeostasis. Changes of liver sulfhydryl group levels and related metabolism were estimated. Significant decrease in liver sulfhydryl group levels during hypoperfusion and sepsis may contribute to various cellular metabolic disorders and destruction in early liver damage.
Zhang
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Institute of Basic Medical Science Research, General Hospital of PLA, Beijing.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D005260:Female; D005978:Glutathione / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism; D007958:Leukocyte Count; D008099:Liver / Q000098:blood supply / Q000378:metabolism*; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000378:metabolism; D018805:Sepsis / Q000150:complications / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism
D013438:Sulfhydryl Compounds; D000255:Adenosine Triphosphate; D005978:Glutathione