[Clinical assessment of various methods of radio-modification in radiotherapy of advanced oropharyngeal cancer].
The purpose of the study was to evaluate the effectiveness of RF-hyperthermia and regional intraarterial hyperglycemia as adjuvant radiotherapy vs conventional radiotherapy of advanced head and neck cancers. Altogether 115 patients with advanced T3-T-4 carcinoma of the tongue, oral cavity and oropharynx underwent external radiotherapy (Co-60). An RF capacitative heating device operating at 40.68 MHz was employed twice a week, a total of 4 sessions per patient. Intratumor temperature was 41.5-43 degrees C. Hyperglycemia was performed via the branches of the carotid artery, a total of 3 sessions per patient. There were 4 groups (1-31 patients on conventional radiotherapy; 2-24 patients on thermoradiotherapy; 3-30 patients on radiotherapy plus regional hyperglycemia; 4-30 patients underwent combined radio-modification). A complete response was 29% for conventional radiotherapy, 67% for thermoradiotherapy, 60% for radiotherapy plus hyperglycemia, and 77% for combined radio-modification. A 2-year local control was found to be 13% for radiotherapy, 37% for thermoradiotherapy, 17% for radiotherapy plus hyperglycemia, and 35% for combined radio-modification. Only hyperthermia was found to improve a 2-year local control of advanced oropharyngeal cancer.
Mardynskiĭ
Iu S
IuS
Vtiurin
B M
BM
Konopliannikov
A G
AG
Zubov
O G
OG
Lopatin
V F
VF
Medvedev
V S
VS
Livshits
L I
LI
D000328:Adult; D000368:Aged; D001786:Blood Glucose; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000628:therapy; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy* / Q000628:therapy; D014466:Ultraviolet Rays
D001786:Blood Glucose
Klinicheskaia otsenka razlichnykh metodik radiomodifikatsii pri luchevoĭ terapii rasprostranennogo raka orofaringeal'noĭ oblasti.