Successful treatment of disseminated Fusarium infection after autologous bone marrow transplantation for acute myeloid leukemia.
Disseminated Fusarium is a rare but life-threatening infection of severely immunocompromised patients. A fatal outcome has been described in all reported cases of Fusarium infection occurring after bone marrow transplantation. We describe a patient who developed disseminated Fusarium infection with a secondary fungal endophthalmitis after an autologous bone marrow transplant for acute myeloid leukemia. This infection was successfully eradicated after neutrophil recovery by prolonged systemic administration of amphotericin B as well as aggressive local therapy including enucleation of the affected eye. The patient remains free of both leukemia and fungal disease more than 4 years after transplant.
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115.
M J
MJ
Robertson
M A
MA
Socinski
R J
RJ
Soiffer
R W
RW
Finberg
C
C
Wilson
K C
KC
Anderson
L
L
Bosserman
D N
DN
Sang
I F
IF
Salkin
J
J
Ritz
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D015353:Eye Enucleation; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000601:surgery; D005670:Fusarium; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D008297:Male; D009181:Mycoses / Q000188:drug therapy* / Q000601:surgery
D000666:Amphotericin B