[Biosynthesis of anthracycline: a new interpretation of the results for daunomycin biosynthesis].
On the basis of literature data and our own experiments the "late" biosynthetic pathway to daunomycin has been interpreted from a new point of view considering both the in vivo biosynthesis and formation of shunt products. In contrast to existing hypotheses proposed by other authors we discuss a modified sequence leading to C-11 oxidation and, as a consequence, understand epsilon-rhodomycinone as a shunt product instead of a biosynthetic intermediate. In addition, a new hypothesis about the "early" steps of the ring formation from polyketides by a sequence of enzyme reactions has been proposed.
Wagner
C
C
Institut für Mikrobiologie und experimentelle Therapie, Jena, Germany.
Eckardt
K
K
Ihn
W
W
Schumann
G
G
Stengel
C
C
Fleck
W F
WF
Tresselt
D
D
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D003630:Daunorubicin / Q000096:biosynthesis* / Q000737:chemistry; D015394:Molecular Structure; D009154:Mutation; D013305:Streptomyces griseus / Q000235:genetics / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D003630:Daunorubicin
Biosynthese der Anthracycline: eine Neuinterpretation der Ergebnisse zur Daunomycin-Biosynthese.