Preparation and performance evaluation of plain proliposomal systems for cytoprotection.
Plain liposomal systems composed of soyabean lecithin, cholesterol and stearylamine were formulated using various approaches. The prepared products were characterized and evaluated for their cytoprotective performance against the necrotizing NSAID's (i.e. aspirin and phenylbutazone). Liposomes derived from proliposomes (effervescent granules based) demonstrated the best cytoprotective activity and physical and stability characteristics. This system was shown to be superior. An increased availability of regular and small sized liposome born phospholipids to the damaged mucosal systems accounted for its better and enhanced performance.
Katare
O P
OP
Department of Pharmaceutical Sciences, Dr H.S. Gour Vishwavidyalaya, Sagar, India.
Vyas
S P
SP
Dixit
V K
VK
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D005753:Gastric Mucosa / Q000187:drug effects*; D008081:Liposomes / Q000494:pharmacology*; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008081:Liposomes; D010713:Phosphatidylcholines