[Treatment with indomethacin for the control of the metabolic disorder caused by a villous adenoma of the rectum].
A 79 year old patient with a previous history of 10 months of mucous diarrhea is admitted due to pre-renal insufficiency, hyponatremia, hypokalemia and metabolic alkalosis secondary to rectal villous adenoma. The volume of the rectal discharge was 2.500 cc/day. Sodium level of the rectal secretion was 145 mEq/L and potassium 20 mEq/L. E2 prostaglandin: 1500 pg/ml. After hydroelectrolytic treatment, a PG synthetase inhibitor (indomethacin) was added to a dosage of 25 mg q/d PO. Rectal discharge was reduced to 500 cc/day, as well as sodium and prostaglandin levels. It has been proved that the use of PG synthetase inhibitors can facilitate the preparatory metabolic control in patients with villous adenoma.
Servicio de Medicina Interna, Hospital General de Galicia-Gil Casares.
C
C
Cutrin Prieto
L
L
Casal Iglesias
A
A
Batalla Eiras
M J
MJ
Meniño Olveira
P
P
Diéguez Gómez
V
V
Lorenzo Zúniga
D000236:Adenoma / Q000150:complications*; D000368:Aged; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D012004:Rectal Neoplasms / Q000150:complications*; D014883:Water-Electrolyte Imbalance / Q000188:drug therapy* / Q000209:etiology
D007213:Indomethacin
Tratamiento con indometacina para el control del trastorno metabólico producido por un adenoma velloso de recto.