Preoperative antibiotic and povidone-iodine preparation of the eye.
We compared gentamicin 0.3% one drop every three hours the night before and the morning of surgery ("half-day regimen") with the same drug one drop qid for three days ("three-day regimen") in 15 eyes undergoing intraocular surgery. Conjunctival cultures of both groups taken before povidone-iodine preparation showed mean colony counts of 3.67 +/- 0.82 in the half-day regimen versus 1.0 +/- 0.43 in the three-day regimen. Conjunctival cultures taken after the administration of a povidone-iodine 5% preparation showed 7.17 +/- 3.52 and 2.75 +/- 0.88, respectively, in the two groups. Although there was a statistical difference in colony counts, topical gentamicin 0.3% given the night before and day of surgery had comparable low colony counts with the three-day course. The 5% povidone-iodine solution was not effective in reducing bacterial flora although it did eliminate all fungal colonies.
Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200.
S R
SR
Grimes
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CE
Mein
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S
Trevino
D001419:Bacteria / Q000302:isolation & purification; D001424:Bacterial Infections / Q000517:prevention & control*; D015169:Colony Count, Microbial; D003228:Conjunctiva / Q000382:microbiology; D004334:Drug Administration Schedule; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D009883:Ophthalmic Solutions; D013508:Ophthalmologic Surgical Procedures; D011183:Postoperative Complications / Q000517:prevention & control*; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000627:therapeutic use*; D011292:Premedication; D011897:Random Allocation
D005839:Gentamicins; D009883:Ophthalmic Solutions; D011206:Povidone-Iodine