Anaphylaxis is enhanced by increased absorption of antigen in postinflammatory state.
Hemagglutinating antibodies and cell-mediated immunity are increased when antigens are injected intraperitoneally (i.p.) into rats during the healing phase of a chemical peritonitis. In the present work, the anaphylactogenic effects of either sensitization or challenge were increased when any of three different antigens were injected i.p. in the postinflammatory state. The postinflammatory state made it possible to sensitize rats for anaphylaxis without any adjuvants at all. Lymph nodes draining the peritoneal cavity had evidence of enhanced absorption of inoculum in the postinflammatory state.
Pathology Department, New York Medical College, Valhalla.
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Levine
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Saltzman
D000311:Adrenal Glands / Q000502:physiology; D000536:Aluminum Hydroxide; D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D002364:Caseins / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D006384:Hemagglutination / Q000276:immunology; D007111:Immunity, Cellular; D007114:Immunization; D007074:Immunoglobulin G / Q000276:immunology*; D007274:Injections, Intraperitoneal; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D010538:Peritonitis / Q000139:chemically induced / Q000276:immunology; D010567:Pertussis Vaccine; D051381:Rats; D011917:Rats, Inbred Lew; D012973:Sodium Hypochlorite / Q000494:pharmacology
D002364:Caseins; D007074:Immunoglobulin G; D010567:Pertussis Vaccine; D000536:Aluminum Hydroxide; D012973:Sodium Hypochlorite