Transection of the superior cerebellar peduncle interferes with the onset and duration of generalized seizures induced by amygdaloid kindling.
We studied the effect of transections at the superior cerebellar peduncle during the evolution of amygdaloid kindling. Dentato- and interposito-thalamic pathways, including the ascending fastigial fibers, were transected in 10 rats at the contralateral side of the stimulated amygdala, and in other 8 at the ipsilateral side. A group of 18 rats was used as control. Contralateral lesion significantly slowed amygdala kindling, while ipsilateral lesion decreased kindled seizure duration. Furthermore, when kindled seizures were reached by 6 control rats, transection of the ipsilateral superior cerebellar peduncle led to reduction of subsequent seizures. These specific effects produced by transection of the superior cerebellar peduncle suggest that the cerebellum could exert a tonic effect over the participating circuitry used by the kindling process.
Unit of Brain Research, Instituto Nacional de Neurología y Neurocirugía, México, Mexico.
C
C
Paz
F
F
Gutiérrez-Baeza
B
B
Bazán-Perkins
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002531:Cerebellum / Q000502:physiology*; D004594:Electrophysiology; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology* / Q000503:physiopathology; D013997:Time Factors