Anticonvulsant and sleep-waking influences of riluzole in a rat model of absence epilepsy.
Six WAG/Rij rats, an animal model of human absence epilepsy, were injected intraperitoneally with riluzole. At 4 mg/kg, riluzole decreased the number, mean duration and spike-frequency of the spontaneously occurring discharges for 3 h. Riluzole also increased slow wave sleep at the expense of waking. As riluzole at 3 mg/kg decreased the number and spike-frequency of the discharges without inducing a sedative effect, this compound could be of therapeutic interest in human absence epilepsy.
Romettino
S
S
Laboratoire de Psychophysiologie, Faculté des Sciences, Université de Nice-Sophia Antipolis, France.
Lazdunski
M
M
Gottesmann
C
C
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D002940:Circadian Rhythm / Q000187:drug effects; D004195:Disease Models, Animal; D004576:Electromyography; D004832:Epilepsy, Absence / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D019782:Riluzole; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D013844:Thiazoles / Q000494:pharmacology*; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D000927:Anticonvulsants; D013844:Thiazoles; D019782:Riluzole