Cardiovascular actions of adenosines, but not adenosine receptors, differ in rat and guinea pig.
This study compared the structure-activity relationships of 16 analogues at the A1 and A2 adenosine receptors (A1AR, A2AR) of rat and guinea pig. Radioligand binding studies revealed no marked differences in the affinities of each analogue at the A1AR of brain cortex or the A2AR of brain striatum. Bioassay employing Langendorff heart preparations showed that the guinea pig is more sensitive than the rat to A1AR-mediated slowing of conduction through the atrioventricular node and, in some instances, to A2AR-mediated coronary vasodilation. That difference could reflect factors such as receptor density or efficacy of coupling to effector systems.
Ueeda
M
M
Department of Internal Medicine, University of South Florida, Tampa 33612.
Thompson
R D
RD
Padgett
W L
WL
Secunda
S
S
Daly
J W
JW
Olsson
R A
RA
D000241:Adenosine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001283:Atrioventricular Node / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003331:Coronary Vessels / Q000187:drug effects*; D003342:Corpus Striatum / Q000378:metabolism; D006168:Guinea Pigs; D011869:Radioligand Assay; D051381:Rats; D011983:Receptors, Purinergic / Q000378:metabolism*; D012044:Regression Analysis; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014661:Vasoconstriction
D011983:Receptors, Purinergic; D000241:Adenosine