Estimating the postantibiotic effect: a two-phase mathematical model.
The postantibiotic effect (PAE) is a suppression of bacterial growth that persists after a short exposure to antimicrobials. The active antibiotic delays the resumption of normal growth. This suppression of bacterial growth following antibiotic removal is described by a two-phase model. The quantification of PAE is a function of the model parameters, for which consistent and asymptotically normal estimators are available.
Biomathematics, Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan 49001.
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MN
Brunden
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BH
Yagi
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Lajiness
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GE
Zurenko
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development*; D008962:Models, Theoretical
D000900:Anti-Bacterial Agents