Selective IgA deficiency, IgG subclass deficiency, and the major histocompatibility complex.
Here we have examined the connection between IgA deficiency, IgG subclass deficiency, and the absence of alleles of complement C4, and show that IgA deficient subjects who have IgG subclass deficiencies may also have an increased frequency of C4 null alleles. In our group, we found an increased incidence of HLA B38 which might reflect the ethnic composition of the patients tested. While family studies are of primary importance to assess the relationships between histocompatibility antigens and immune deficiency, these studies are complicated by the observation that C4 null alleles are not always inherited with the humoral defect.
Department of Medicine, Mount Sinai Medical Center, New York City, New York 10029.
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Cunningham-Rundles
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Fotino
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Rosina
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Peter
D000328:Adult; D002648:Child; D002896:Chromosomes, Human, Pair 6; D015934:Complement C4a / Q000096:biosynthesis / Q000235:genetics; D004406:Dysgammaglobulinemia / Q000235:genetics / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000096:biosynthesis*; D015788:HLA-A1 Antigen / Q000096:biosynthesis; D015795:HLA-B8 Antigen / Q000096:biosynthesis; D015803:HLA-DR3 Antigen / Q000096:biosynthesis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D016130:Immunophenotyping; D007223:Infant; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D006680:HLA Antigens; D015788:HLA-A1 Antigen; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015934:Complement C4a