Urinary mutagens in cosmetologists and dental personnel.
Cosmetologists are occupationally exposed to a wide range of toxic chemicals both dermally and by inhalation. Since many of these chemicals are mutagens and may be excreted in urine, the Ames Salmonella typhimurium assay was used to determine the presence of direct-acting and promutagens in the urine of practicing cosmetologists in central New York State. A comparable group (age, gender, smokers) of dental hygienists and assistants in the same geographic area was used as the control cohort. The cosmetologists had a significantly higher (39 vs. 24%, p less than .03) frequency of direct-acting urinary mutagens but there was no difference between the groups in the frequency of promutagens. In the multivariate model, cosmetologists were at two times the risk of direct-acting mutagens compared to dental workers. Smoking regularly, within 24 h of taking the urine sample, and the number of cigarettes smoked daily were not associated significantly with direct-acting mutagens in urine. Similarly, having had a hair permanent or hair dyed within 7 d of urine sampling, years of employment, age, gender and use of protective gear were not predictive of direct-acting urinary mutagens. In contrast, employment was not associated with urinary promutagens but the risk was significantly increased with increasing age and cigarette smoking. Among possible adverse health symptoms queried, only the prevalence of skin rashes differed between the cosmetologists (29%) and dental personnel (15%) (p less than .05).
Department of Pharmacology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853-7401.
J G
JG
Babish
J M
JM
Scarlett
S E
SE
Voekler
W H
WH
Gutenmann
D J
DJ
Lisk
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003358:Cosmetics / Q000009:adverse effects*; D003726:Dental Assistants; D003756:Dental Hygienists; D005260:Female; D006203:Hair Preparations / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis*; D016273:Occupational Exposure; D012907:Smoking; D011795:Surveys and Questionnaires
D003358:Cosmetics; D006203:Hair Preparations; D009153:Mutagens