Perhexiline maleate-induced hepatitis.
We report on a case of perhexiline maleate-induced hepatitis secondary to a long-term administration of recommended daily dosages of 300 mg. The patient had a spectacular weight loss of 29 kg. He developed hepatitis, which subsided after drug withdrawal. Our electron-microscopic findings with the typical inclusion bodies and impaired hydroxylation capacity point to an underlying metabolic disorder as the pathogenetic mechanism.
Satz
N
N
Department of Medicine, University Hospital, Zurich.
Täuber
M
M
Streuli
R
R
Spycher
M A
MA
Maurer
R
R
D000787:Angina Pectoris / Q000188:drug therapy; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D003647:Debrisoquin; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010480:Perhexiline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors
C023470:perhexiline maleate; D010480:Perhexiline; D003647:Debrisoquin