[The protective properties of monoamines and amino acids in an indomethacin-induced stomach lesion in rats].
Serotonin, histamine, tryptophan administered in low doses were shown to protect the rat gastric mucosa against indomethacin-induced hemorrhages. When administered in high doses, serotonin retained the protective properties, while histamine and histidine, on the contrary, increased the hemorrhagic lesion of the tissue. Tryptophan and histidine given in low doses promoted a decrease of the indomethacin elevated levels of serotonin and histamine in the gastric mucosa.
Sergeev
V A
VA
Levkovets
V S
VS
D000596:Amino Acids / Q000627:therapeutic use*; D000818:Animals; D015306:Biogenic Monoamines / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007213:Indomethacin / Q000633:toxicity*; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*
D000596:Amino Acids; D015306:Biogenic Monoamines; D007213:Indomethacin
Zashchitnye svoĭstva nekotorykh monoaminov i aminokislot pri indometatsinom povrezhdenii zheludka krys.