[Central and peripheral monitoring of the cellular redox state after reduced glutathione administration in the rat].
In this study we measured reduced glutathione as DTNB reactive material in different brain areas as well as in liver and kidney of rat, before and after exogenous administration of GSH. Treatment with GSH produced an increase in DTNB positive material as well as a decrease of lipoperoxidation, in central and peripheral organs of rat, suggesting the possibility of an exogenous modulation of redox balance in mammalian cells.
Istituto di Chimica Biologica, Facoltà di Medicina Università di Catania.
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Calabrese
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Calderone
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Russo
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Rizza
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D005978:Glutathione / Q000032:analysis* / Q000493:pharmacokinetics / Q000494:pharmacology; D007668:Kidney / Q000737:chemistry / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008315:Malondialdehyde; D005978:Glutathione; D010100:Oxygen
Modulazione centrale e periferica dello stato redox cellulare dopo somministrazione di glutatione ridotto nel ratto.