Macrophage hydrogen peroxide production and phagocytic function are decreased following phagocytosis mediated by Fc receptors but not complement receptors.
Previous in vivo and in vitro studies have shown that the phagocytosis of IgG-coated erythrocytes results in a depression of macrophage function. The present study compared the effect of phagocytosis mediated by Fc receptors with that mediated by complement receptors. The phagocytosis of IgG-coated erythrocytes by elicited peritoneal macrophages depressed their capacity to produce hydrogen peroxide as well as phagocytic function. Phagocytosis of erythrocytes coated with IgM and complement had neither of these effects. These results implicate the intracellular signaling that results from Fc receptor mediated phagocytosis in the depression of macrophage function that is caused by phagocytosis.
Department of Physiology and Cell Biology, Albany Medical College, New York 12208.
D J
DJ
Loegering
M G
MG
Schwacha
D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D006861:Hydrogen Peroxide / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D011951:Receptors, Complement / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D011951:Receptors, Complement; D011961:Receptors, Fc; D006861:Hydrogen Peroxide; D013755:Tetradecanoylphorbol Acetate