[The role of glycosaminoglycans in the local regulation of hemopoiesis in exposure of the body to extreme factors].
The authors studied the role of glycosaminoglycans as component of hematopoiesis-inducing microenvironment in the regulation of hematopoiesis. Following injection of preparations of these compounds to experimental animals (male CBA mice), their concentration changed most markedly in the bone marrow and spleen. The effect of acid glycosaminoglycans on the hematopoietic cells is realized through an increase of the concentration of calcium, cAMP, and leads to activation of granulocytopoiesis. It was shown in experiments with heparin that desulfation has no effect on their hematopoietic activity.
Iastrebov
A P
AP
Iushkov
B G
BG
Savel'ev
L I
LI
D000818:Animals; D001853:Bone Marrow / Q000737:chemistry / Q000187:drug effects; D006025:Glycosaminoglycans / Q000032:analysis / Q000502:physiology*; D006410:Hematopoiesis / Q000187:drug effects* / Q000502:physiology; D006493:Heparin / Q000031:analogs & derivatives / Q000494:pharmacology; D006820:Hyaluronic Acid / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000737:chemistry / Q000187:drug effects; D013997:Time Factors
D006025:Glycosaminoglycans; C044153:heparin, N-desulfated; D006820:Hyaluronic Acid; D006493:Heparin
Rol' glikozaminoglikanov v lokal'noĭ reguliastii gemopoéza pri vozdeĭstvii na organizm ékstremal'nykh faktorov.