Chromosome changes in a squamous cell carcinoma of the vagina.
The findings on direct chromosome preparations of a moderately differentiated squamous cell carcinoma of the vagina are described. Most counts were in the range 82-86. Eight markers were present in at least five of six metaphases karyotyped: 3p- (1-2 copies); i(5p) or possibly 5q- (2-3 copies); i(8q) (2 copies); 11q- (2-4 copies); 15p+ (1-2 copies), a probable 18q- (1 copy), 22p+ (1 copy), and minute acrocentric (2-4 copies). Numerical changes included extra copies of chromosomes 7 and 13, but only one copy of chromosome 11 was present.
Department of Cancer Research, Mount Vernon Hospital, Northwood, Middlesex, England.
N B
NB
Atkin
M F
MF
Fox
D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000235:genetics*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D014596:Uterine Prolapse / Q000150:complications / Q000235:genetics; D014625:Vaginal Neoplasms / Q000150:complications / Q000235:genetics*