Primary lymphoma of bone: a review of 13 cases emphasizing orthopaedic problems.
The records of 13 patients treated in the radiotherapy department in Newcastle 1973-1988 for primary lymphoma of bone (PLB) were reviewed. Treatment was by radiotherapy in combination with surgery and/or chemotherapy. Cause-specific disease-free survival at 5 years in 75%. Eight patients had PLB in a weight-bearing bone: four of these patients suffered pathological fractures in the treated bone. The radiological differentiation of recurrent PLB and radiation osteitis remains unsatisfactory. None of the four post-treatment pathological fractures in this series was due to recurrent PLB. None of these fractures healed spontaneously. All four patients remain disease-free but all have restricted mobility and require walking aids. PLB in weight-bearing bones is associated with long-term fragility and propylactic stabilization of the affected bone should be considered.
Department of Radiotherapy, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
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Lucraft
D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000150:complications / Q000401:mortality / Q000628:therapy*; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate