[Alpha-hemolytic streptococcal septicemia and meningitis in immunocompromised children].
Many kinds of microorganisms can produce toxic septicemia in immunocompromised hosts. We are reporting alpha-hemolytic streptococcal septicemia and meningitis in two children with hematological malignancies. [Case 1] 6 year old girl who had been suffering from acute lymphocytic leukemia. She had sepsis and bacterial meningitis in maintenance-therapy for leukemia. Streptococcus sanguis was isolated from the blood and cerebrospinal fluid (CSF). [Case 2] 11 year old girl who had had malignant lymphoma (non-Hodgkin type). She also had sepsis and bacterial meningitis due to Streptococcus mitis which was isolated from blood and CSF in maintenance-therapy. Both cases had been treated with anti-cancer drugs and had severe granulocytopenia. Positive rate of blood cultures during the recent 6 years (1984.1-1989.12) at our department was 6.0% (total number of cultures were 2,019, positive cultures were 121). Strains of 131 bacteria were determined; Gram-positive cocci were 70 strains (53.4%) and Gram-negative rods were 52 strains (39.7%). Fifteen strains (11.5%) of alpha-hemolytic Streptococci were isolated during 6 years. One hundred thirteen cases of septicemia were analysed in medical charts and 12 cases of alpha-hemolytic streptococcal septicemia were observed (5 cases with infective endocarditis and 7 cases in immunocompromised states).
Sasaki
H
H
Department of Pediatrics, School of Medicine, Kurume University.
Yoshinaga
Y
Y
Oki
S
S
Tsumura
N
N
Oda
K
K
Koga
T
T
Sakata
Y
Y
Tominaga
K
K
Motohiro
T
T
Yamashita
F
F
D002648:Child; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D016920:Meningitis, Bacterial / Q000150:complications* / Q000382:microbiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications; D018805:Sepsis / Q000150:complications* / Q000382:microbiology; D013290:Streptococcal Infections / Q000150:complications*; D013291:Streptococcus / Q000302:isolation & purification