Rectal mucosa damage in rabbits after subchronical application of suppository bases.
The effect of suppository bases on rabbit rectal mucosa was investigated using six triglyceride bases, polyethylene glycol, and a triglyceride base combined with monoglycerides or fatty acids and methyl esters of those acids. Rectal irritation was evaluated and scored according to defined pathological features. "Pure" triglycerides and a triglyceride to which a nonionic surfactant was added caused severe mucosal damage with ulceration and inflammation. Hyperemia was characteristic for irritation by polyethylene glycol suppositories. Mucosal damage by a pure triglyceride combined with monoglycerides or fatty acids and methyl esters of those acids was similar but statistically less pronounced than with all other bases.
R&D Department of Vandemoortele N.V., Izegem, Belgium.
C
C
De Muynck
C
C
Cuvelier
D
D
Van Steenkiste
L
L
Bonnarens
J P
JP
Remon
D000818:Animals; D005079:Excipients / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000473:pathology*; D007509:Irritants; D008297:Male; D011092:Polyethylene Glycols; D011817:Rabbits; D012002:Rectal Diseases / Q000139:chemically induced / Q000473:pathology*; D013488:Suppositories; D014280:Triglycerides / Q000633:toxicity
D005079:Excipients; D007509:Irritants; D013488:Suppositories; D014280:Triglycerides; D011092:Polyethylene Glycols