Improvement in diabetic neuropathy 4 years after successful pancreatic and renal transplantation.
We have studied the fate of diabetic neuropathy and autonomic function in 13 patients with long standing Type 1 (insulin-dependent) diabetes mellitus following combined pancreas and kidney transplantation. Fifteen diabetic patients with a kidney graft only served as controls. After initial improvement of the neuropathy in both groups, probably caused by the elimination of uraemia, a continuous improvement during the 48 months study was seen in the euglycaemic pancreas graft recipients only. Autonomic (parasympathetic) function improved only slightly and to a similar extent in both groups.
Department of Clinical Neurophysiology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
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Solders
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Tydén
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Persson
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CG
Groth
D000200:Action Potentials; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology* / Q000601:surgery*; D003929:Diabetic Neuropathies / Q000503:physiopathology* / Q000517:prevention & control; D004594:Electrophysiology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D009431:Neural Conduction; D009475:Neurons, Afferent / Q000502:physiology; D016035:Pancreas Transplantation / Q000502:physiology*; D011446:Prospective Studies