9-O-acetylated sialic acid, a receptor determinant for influenza C virus and coronaviruses.
Influenza C virus and a group of coronaviruses, a typical representative of which is bovine coronavirus, use the same strategy for binding to cells. Surface components containing 9-O-acetylated sialic acid are recognized as cellular receptors by these viruses. In addition to the receptor determinant both virus groups have a receptor-destroying enzyme in common, which has been identified as a sialate 9-O-acetylesterase. Differences are, however, found in the distribution of these activities on the viral surface proteins. The influenza C glycoprotein HEF is a multifunctional protein, which is responsible for receptor-binding, receptor-inactivation and fusion. In the case of coronaviruses these activities are functions of two different glycoproteins, S and HE.
Institut für Virologie, Philipps-Universität Marburg, Germany.
G
G
Herrler
S
S
Szepanski
B
B
Schultze
D000818:Animals; D002240:Carbohydrate Sequence; D002460:Cell Line; D003332:Coronaviridae / Q000502:physiology*; D009982:Gammainfluenzavirus / Q000502:physiology*; D008969:Molecular Sequence Data; D011991:Receptors, Virus / Q000502:physiology*; D012794:Sialic Acids / Q000502:physiology*
D011991:Receptors, Virus; D012794:Sialic Acids; C025676:9-O-acetyl-N-acetylneuraminic acid