[Decreased plasma carnitine in Type I diabetes mellitus].
Realizing the importance of carnitine for the lipid and carbohydrate metabolism and the possible role for glucose utilization and myocardial function carnitine concentrations in type I and type II diabetic patients in plasma, erythrocytes and 24 h urine were determined. The plasma levels of carnitine were significantly diminished in type I diabetic patients compared to controls, while carnitine concentrations in erythrocytes and 24 h urine did not differ from controls. Plasma carnitine levels did not change significantly during the diurnial profile. No correlation between HbA1c and carnitine levels was observed in the diabetic patients.
Pregant
P
P
Institut für Medizinische Chemie, Universität Wien.
Schernthaner
G
G
Legenstein
E
E
Lienhart
L
L
Bruck
S
S
Schnack
C
C
Kaiser
E
E
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002331:Carnitine / Q000097:blood* / Q000652:urine; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D002331:Carnitine; D006442:Glycated Hemoglobin
Vermindertes Plasmacarnitin bei Typ-I Diabetes mellitus.