X-ray conformational study of hydrazino peptide analogues.
We have solved the crystal structures of nine pseudo-peptide analogues deriving from the hydrazino analogue of glycine or valine (N beta H2-N alpha H-C alpha HR-CO2H, R = H or iPr) or proline (N beta H2-N alpha-C alpha H-CO2H) and containing the hydrazide (CO-N beta H-N alpha less than) or N beta-Z-aminoamide [formula; see text] [CO-N alpha(N beta HZ)] peptidomimetic link. This study gives access to the average geometry of these two links, to their inter- and intramolecular interaction modes, and to their influence on the conformational properties of the molecules.
CNRS-URA-809, Université de Nancy I, Vandoeuvre, France.
A
A
Aubry
D
D
Bayeul
J P
JP
Mangeot
J
J
Vidal
S
S
Sterin
A
A
Collet
A
A
Lecoq
M
M
Marraud
D000595:Amino Acid Sequence; D006834:Hydrazines / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry; D011487:Protein Conformation; D014961:X-Ray Diffraction
D006834:Hydrazines; D010455:Peptides