[Biosynthesis of anthracycline: a new interpretation of the results for daunomycin biosynthesis].
On the basis of literature data and our own experiments the "late" biosynthetic pathway to daunomycin has been interpreted from a new point of view considering both the in vivo biosynthesis and formation of shunt products. In contrast to existing hypotheses proposed by other authors we discuss a modified sequence leading to C-11 oxidation and, as a consequence, understand epsilon-rhodomycinone as a shunt product instead of a biosynthetic intermediate. In addition, a new hypothesis about the "early" steps of the ring formation from polyketides by a sequence of enzyme reactions has been proposed.
Institut für Mikrobiologie und experimentelle Therapie, Jena, Germany.
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C
Wagner
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Eckardt
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Ihn
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Schumann
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Stengel
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Fleck
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Tresselt
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D003630:Daunorubicin / Q000096:biosynthesis* / Q000737:chemistry; D015394:Molecular Structure; D009154:Mutation; D013305:Streptomyces griseus / Q000235:genetics / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D003630:Daunorubicin
Biosynthese der Anthracycline: eine Neuinterpretation der Ergebnisse zur Daunomycin-Biosynthese.