Pharmacogenetics and drug metabolism: an Irish perspective.
Genetic factors, particularly in relation to control of liver drug metabolism, are a major cause of variability in the response to drugs. In 145 Irish subjects 48% were fast acetylators of sulphadimidine in contrast to 80% in Chinese subjects. Eleven (7.6%) of our Irish population showed an improved ability to oxidise delrisoquine. The therapeutic implications of these findings are discussed.
Holland
P
P
Department of Pharmacology and Therapeutics, Trinity College Medical School, St. James's Hospital, Dublin.
Barry
M
M
Feely
J
J
D000107:Acetylation; D000328:Adult; D002681:China; D003647:Debrisoquin / Q000378:metabolism*; D006801:Humans; D007494:Ireland; D008660:Metabolism / Q000235:genetics; D010084:Oxidation-Reduction; D010641:Phenotype; D011110:Polymorphism, Genetic; D013418:Sulfamethazine / Q000378:metabolism*
D013418:Sulfamethazine; D003647:Debrisoquin