Acute ethanol treatment induces a bimodal response of phospholipid acylation rates in rat red blood cells.
A single intraperitoneal injection of ethanol (4 g/kg) in rats elicited a bimodal response of acylation rates in phosphatidylcholine and phosphatidylethanolamine of intact red blood cells. Within an initial period, ethanol inhibited acylation rates. The inhibition then reversed, leading to increased values which persisted as long as ethanol was present in plasma. Acylation rates were not correlated to ethanol concentrations in plasma. We suggest that red cells first desensitize to, then overcompensate for the inhibitory effect of ethanol on acylation reactions. These adaptive changes may be one of the events mediating membrane tolerance to ethanol.
INSERM U.260, Faculté de Médecine, Marseille, France.
A
A
Vérine
A
A
Valette
D
D
Richard
J
J
Boyer
D000215:Acylation; D000818:Animals; D002855:Chromatography, Thin Layer; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000378:metabolism*; D010714:Phosphatidylethanolamines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D000431:Ethanol