Insulin-like growth factor 1 (IGF-1) in burn patients.
Variations in growth factor IGF-1 levels during wound healing were assessed in 23 patients with burns of varying extent and severity. The patients were followed during the postburn period and the IGF-1 levels were regularly measured by radioimmunoassay. All patients with large burns had reduced IGF-1 levels which correlated with the surface area of burn. The most plausible reason for the suppressed IGF-1 level in these patients may be diffusion from the burned skin as we have found a strong correlation between IGF-1 and serum albumin. The reduced IGF-1 levels may contribute to impaired wound healing in these patients.
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
S
S
Møller
M
M
Jensen
P
P
Svensson
N E
NE
Skakkebaek
D000328:Adult; D001830:Body Surface Area; D002056:Burns / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012709:Serum Albumin / Q000032:analysis; D014945:Wound Healing / Q000502:physiology
D012709:Serum Albumin; D007334:Insulin-Like Growth Factor I