Relative inhibitory activity of berberine-type alkaloids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.
Forty eight derivatives of berberine-type alkaloids were examined for their inhibition activity against the induction of edema on mouse ear by application of 12-O-tetradecanoylphorbol-13-acetate (TPA). Berberine had an inhibitory effect against TPA-induced ear edema at a grade corresponding to those of quercetin, caffeine and cepharanthine. Berberine derivatives had stronger inhibitory activity than palmatine derivatives. 9-N,N-Diphenylcarbamoyl derivatives of both 9-demethylberberine and 9-demethylpalmatine had rather strong activity. These inhibitory activities are about ten times the activity of the respective mother compounds. Furthermore, 9-N-monophenylcarbamoyl derivatives and N,N-diphenylcarbamoyl chloride are found to have no effect.
College of Pharmacy, Nihon University, Chiba, Japan.
K
K
Yasukawa
M
M
Takido
T
T
Ikekawa
F
F
Shimada
M
M
Takeuchi
S
S
Nakagawa
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001599:Berberine / Q000494:pharmacology*; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D013755:Tetradecanoylphorbol Acetate
D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001599:Berberine; D013755:Tetradecanoylphorbol Acetate