[Can cisplatin renal toxicity be prevented?].
Cis diamminedichloroplatinum (CDDP) is a widely used anticancer agent particularly effective in the treatment of solid tumors. Dose limiting toxicity of CDDP was shown to be renal. Numerous methods to reduce this nephrotoxicity have been proposed. Hydration remains the best protection against acute CDDP nephrotoxicity in both the clinical and experimental setting. In man, no controlled studies have demonstrated the efficacy of furosemide and mannitol in the reduction of the CDDP renal toxicity. Studies have shown, however, that sodium thiosulfate offers some nephroprotection. To date, no controlled studies have demonstrated any benefit in the use of calcium channel blockers on CDDP renal toxicity in man. New drugs such as carboplatin have recently been introduced that theoretically have less renal toxicity, but evidence to support these claims are lacking. CDDP nephro protection remains a problem of current clinical interest and has yet not to be totally resolved.
Service de Néphrologie, Hôpital de la Pitié, Paris.
G
G
Brillet
G
G
Deray
D
D
Bunker
M
M
Ben Hmida
A
A
Baumelou
C
C
Jacobs
D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects*; D004232:Diuretics / Q000627:therapeutic use; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy; D013885:Thiosulfates / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D004232:Diuretics; D013885:Thiosulfates; C017717:sodium thiosulfate; D002945:Cisplatin
Peut-on prévenir la toxicité rénale du cisplatine?