[Colony-stimulating factor activity in malignant pleural effusions and its augmentation by local administration of interleukin 2].
The activity of endogenous colony stimulating factor (CSF) in pleural effusions of patients with lung cancer was measured quantitatively by colony-forming bioassay. Before treatment malignant effusions contained various levels of CSF activities. Anti-GM-CSF and anti-M-CSF antibodies neutralized approximately 60% and 70% of CSF activities in malignant effusions, respectively. Significant increase in the CSF activity in malignant effusion was seen during intrapleural injections of recombinant interleukin-2 (IL-2). Thus, in vivo treatment with IL-2 can induce production of endogenous CSF which may be responsible for proliferation and differentiation of mononuclear phagocytes.
Third Department of Internal Medicine, University of Tokushima School of Medicine.
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Nakanishi
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Sone
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Ogura
D000328:Adult; D000368:Aged; D002455:Cell Division; D003115:Colony-Stimulating Factors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007267:Injections; D007376:Interleukin-2 / Q000008:administration & dosage / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D008264:Macrophages / Q000166:cytology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010994:Pleura; D016066:Pleural Effusion, Malignant / Q000209:etiology / Q000378:metabolism* / Q000628:therapy; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology
D003115:Colony-Stimulating Factors; D007376:Interleukin-2; D011994:Recombinant Proteins