[Nasal provocation test with histamine: rhinomanometry study of normal subjects].
Nasal reactivity to histamine was evaluated in 40 normal subjects. The application of a chloride histamine solution (1 mg) registered in 90% of the subjects the appearance of sneezing with the number of sneezes ranging between one and fourteen (5.7 +/- 3.76) and an average increase in the total resistence in the inspiration phase of 93.1% (+/- 63.2) and in the expiration phase of 98.1% (+/- 60.5) with a range between 37.7% and 24.1%. The authors conclude that sneezing and above all nasal congestion evaluated rhinomanometrically represent two important parameters in the evaluation of nasal reaction; an increase greater than or equal to 200% of the total nasal resistance can surely be considered an index of nasal hyperreactivity.
Istituto Policattedra di Otorinolaringoiatria, Università di Bari.
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D000293:Adolescent; D000328:Adult; D000403:Airway Resistance; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009299:Nasal Provocation Tests; D012016:Reference Values; D012912:Sneezing / Q000187:drug effects
D006632:Histamine
Il test di provocazione nasale con istamina: studio rinomanometrico nel soggetto normale.