Evaluation of genotoxicity of clofazimine, an antileprosy drug, in mice in vivo. III. Sister chromatid exchange analysis in bone marrow cells.
The potential genotoxicity of an antileprosy drug, clofazimine, was evaluated in mice in an in vivo model by sister chromatid exchange (SCE) analysis. Three different dose levels (4, 20 and 40 mg/kg) were tested, and the animals were treated once daily for 15 days. Sister chromatid differential staining was done by BrdU-tablet implantation and FPG technique. All the doses tested here elevated the SCE frequencies significantly and the increases showed a significant positive correlation with the doses. The results confirm our earlier findings based on metaphase analysis and micronucleus test in the same species.
Environmental Mutagenesis Unit, School of Life Sciences, Sambalpur University, Orissa, India.
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D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002991:Clofazimine / Q000627:therapeutic use / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007918:Leprosy / Q000188:drug therapy; D008297:Male; D051379:Mice; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D002991:Clofazimine