[Benefits of ecogenetics in Hungary].
Five enzymes and one protein were studied in 10 ethnical and two reference groups involving 1370 persons. The frequency of atypical heterozygotes of plasma cholinesterase was 2.7%. Aldehyde dehydrogenase I isozyme deficiency was found in four persons including two gypsies. The low paraoxonase activity was found in 48.7% of persons examined. The proportion of gene frequencies of sigma-ALADH-1 and sigma-ALADH-2 in the locus of sigma-amino-levulinic acid dehydratase was 9:1. The percentage of slow acetylators was 56.9% in the total study sample. The rate of heterozygotes in Pi alleles of alpha 1-antitrypsin (protease-inhibitor) was 3.7% and one Pi ZZ phenotype could be observed.
Humángenetikai és Teratológiai Osztály, Országos Közegészségügyi Intézet, WHO Orökletes Artalmak Társadalmi Megelözése Együttmüködési Központ, Budapest.
E
E
Czeizel
H G
HG
Benkmann
W H
WH
Goedde
D000444:Aldehyde Dehydrogenase / Q000172:deficiency; D002802:Cholinesterases / Q000032:analysis; D004463:Ecology; D005006:Ethnicity; D005787:Gene Frequency; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D006814:Hungary; D010641:Phenotype; D011480:Protease Inhibitors
D011480:Protease Inhibitors; D000444:Aldehyde Dehydrogenase; D002802:Cholinesterases
Az ökogenetika magyarországi hasznosítása.