Evaluation of low-molecular gelatin as a pharmaceutical additive for rapidly absorbed oral dosage formulation.
The dissolution behavior of ibuprofen from a kneaded mixture with low-molecular gelatin (LM gelatin) has been studied in comparison to kneaded mixtures prepared with other additives. Their in vivo absorption behaviors were also examined. The LM gelatin markedly enhanced the dissolution rate of ibuprofen compared to that with polyethylene glycol (PEG) 6000, dextran T10 or pullulan. Oral administrations of the kneaded mixture to beagle dogs showed the LM gelatin to be most effective in accelerating the absorption rate of ibuprofen among the additives used.
Kimura
S
S
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Imai
T
T
Otagiri
M
M
D000818:Animals; D004285:Dogs; D005079:Excipients; D005780:Gelatin / Q000737:chemistry / Q000494:pharmacology*; D007052:Ibuprofen / Q000008:administration & dosage / Q000493:pharmacokinetics; D007408:Intestinal Absorption / Q000187:drug effects*
D005079:Excipients; D005780:Gelatin; D007052:Ibuprofen