N6-cyclopentyladenosine impairs passive avoidance retention by selective action at A1 receptors.
The effects of N6-cyclopentyladenosine (CPA), a highly selective agonist for adenosine A1 receptors, on retention of one-trial inhibitory avoidance behavior were examined in mice. Water-deprived animals were trained to avoid drinking by pairing foot-shock with licks from a water spout. Retention was measured as the suppression of drinking (latency to drink) 48 h following training. Administration of CPA (0.15-2.25 mumol/kg) 30 min prior to training produced a dose-dependent impairment in memory of the original avoidance task. The CPA-elicited deficits in retention performance were blocked by pretreatment with 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective A1 receptor antagonist; DPCPX (15 mumol/kg) administration alone had no effect on retention performance. These findings suggest that selective activation of a presumably central population of A1 receptors may impair retention performance and influence information processing.
Normile
H J
HJ
Department of Psychiatry, Wayne State University, School of Medicine, Detroit, MI 48201.
Barraco
R A
RA
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004347:Drug Interactions; D004597:Electroshock; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D011983:Receptors, Purinergic / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014868:Water Deprivation; D014970:Xanthines / Q000494:pharmacology
D011983:Receptors, Purinergic; D014970:Xanthines; C048599:N(6)-cyclopentyladenosine; C051360:1,3-dipropyl-8-cyclopentylxanthine; D000241:Adenosine