Synthesis of cobalt(II) and nickel(II) complexes of Ceclor (cefaclor) and preliminary experiments on their antibacterial character.
Cobalt(II) and nickel(II) complexes of the antibacterial drug Ceclor have been synthesized and characterized on the basis of their elemental analysis, molar conductance, magnetic moment and electronic and infrared spectral data. These complex have been, then subjected to screening for their antibacterial properties against bacterial species such as Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli. In comparison to uncomplexed Ceclor, the metal complexes have been shown to be more antibacterial.
Department of Chemistry, Islamia University, Bahawalpur, Pakistan.
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Chohan
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002433:Cefaclor / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003035:Cobalt; D002433:Cefaclor; D009532:Nickel