Autoantibodies to the collagen-like region of C1Q deposit in glomeruli via C1Q in immune deposits.
The autoantibodies to the collagen-like region of C1q (CLR), purified from two patients with systemic lupus erythematosus, deposited in mouse glomeruli when human C1q was present in antigen-antibody complexes in glomeruli. The immune deposits with C1q in mouse glomeruli were achieved by the administration of cationized immune complexes containing human C1q. The presented data suggest that the autoantibodies to CLR could enhance the pathogenic role of immune complexes deposited in glomeruli by binding to C1q in immune deposits. These findings may explain the association of autoantibodies to CLR with proliferative lupus nephritis.
Department of Medicine, University of Washington, Seattle 98195.
S
S
Uwatoko
V J
VJ
Gauthier
M
M
Mannik
D000818:Animals; D001323:Autoantibodies / Q000378:metabolism*; D003094:Collagen / Q000276:immunology*; D015922:Complement C1q / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL
D001323:Autoantibodies; D015922:Complement C1q; D003094:Collagen