Immunoelectron microscopic localization of fibronectin and complement to 'dense bodies' in Bowman's capsule and the glomerular basement membrane in membranous nephropathy.
This study describes dense bodies seen in Bowman's capsule and the glomerular basement membrane in biopsies of membranous glomerulonephritis. Within these bodies, silver-enhanced immunogold labelling demonstrated the presence of fibronectin and the complement component C3b. These results suggests that dense bodies may play a role in opsonization and the immune process in membranous glomerulonephritis.
Electron Microscope Unit, Prince Henry Hospital, Little Bay, Sydney, Australia.
M
M
Slater
D001485:Basement Membrane / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D003165:Complement System Proteins / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D015433:Glomerulonephritis, Membranous / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D016253:Microscopy, Immunoelectron
D005353:Fibronectins; D003165:Complement System Proteins