Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children.
Antinematodal efficacy of Saussurea lappa roots (Qust-e-Shereen) and anticestodal effect of Nigella sativa seeds (Kalonji) was studied in children infected naturally with the respective worms. The activities were judged on the basis of percentage reductions in the faecal eggs per gram (EPG) counts. The 50 mg/kg single dose of S. lappa and equivalent amount of its methanolic extract produced on days 7 and 15 percentage EPG reduction similar to 10 mg/kg of pyrantel pamoate. Similarly, single oral administration of 40 mg/kg of N. sativa, equivalent amount of its ethanolic extract and 50 mg/kg of niclosamide reduced the percentage of EPG counts not significantly different from each other on the days 7 and 15. Therefore, it is conceivable that these indigenous medicinal plants contain active principles effective against nematodes and cestodes. The crude drugs did not produce any adverse side effects in the doses tested.
Department of Physiology and Pharmacology, University of Agriculture, Faisalabad.
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MS
Akhtar
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Riffat
D000923:Anticestodal Agents; D000969:Antinematodal Agents; D001198:Ascaridiasis / Q000188:drug therapy / Q000628:therapy*; D002648:Child; D005243:Feces / Q000469:parasitology; D006801:Humans; D006925:Hymenolepiasis / Q000188:drug therapy / Q000628:therapy*; D008519:Medicine, Traditional; D009534:Niclosamide / Q000627:therapeutic use; D010154:Pakistan; D010270:Parasite Egg Count; D010946:Plants, Medicinal; D011716:Pyrantel Pamoate / Q000627:therapeutic use; D013622:Taeniasis / Q000188:drug therapy / Q000628:therapy*
D000923:Anticestodal Agents; D000969:Antinematodal Agents; D011716:Pyrantel Pamoate; D009534:Niclosamide