Effect of Salvia haematodes on sexual behaviour of male rats.
The effect of an ethanolic extract of Salvia haematodes roots was studied on the sexual behaviour of male rats. In the initial experiments, male sexual responses were assessed by recording penile erection, licking and grooming of genitals and copulatory movement in absence of females. In the second set, copulatory behaviour was observed by caging males with a receptive female brought into estrus with s.c. injection of estradiol benzoate and progesterone. The frequencies of mounting and intromission and latency of the ejaculation were recorded. The results show that the extract (500 mg/kg, orally) produced a significant increase in episodes of penile erection. The drug was found to enhance the orientation of males towards the female by increased anogenital investigatory behaviour and enhanced licking and grooming of the genitals. The extract also increased the ejaculation latency. These findings support the folk use of this plant as aphrodisiac and for the treatment of premature ejaculation.
College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
M W
MW
Islam
M
M
Tariq
A M
AM
Ageel
M S
MS
al-Said
A M
AM
al-Yhya
D000818:Animals; D003307:Copulation / Q000187:drug effects; D000431:Ethanol; D005260:Female; D008297:Male; D009949:Orientation / Q000187:drug effects; D010410:Penile Erection / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D010936:Plant Extracts; D000431:Ethanol