Myocardial infarction in a patient with factor XI deficiency and a lupus anticoagulant.
A 64-year-old man with both Factor XI deficiency and a lupus anticoagulant who suffered two myocardial infarctions within a 3-month period is described. Although thromboembolic disorders, including myocardial infarction, have been associated with the antiphospholipid syndrome, myocardial infarction in patients with Factor XI deficiency is rare. The potential role of Factor XIa in fibrinolysis is discussed.
Humphries
J E
JE
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908.
Schlein
A E
AE
Sarembock
I J
IJ
Gonias
S L
SL
D016736:Antiphospholipid Syndrome / Q000150:complications*; D005173:Factor XI Deficiency / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000209:etiology*