Expression of lymphocyte homing receptor gene is lost in multi-drug-resistant variants of human T-lymphoblastoid CCRF-CEM cells.
The 2.2-kb human cDNA clone PBL32, encoding for the lymphocyte homing receptor (LHR) was used to study the expression of this determinant in multi-drug-resistant (MDR) variants of human T-lymphoblastoid CCRF-CEM (CEM) cells. LHR is significantly associated with the drug-sensitive phenotype, its expression being progressively and quantitatively reduced in MDR variants of CEM cells according to the extent of drug resistance.
Cianfriglia
M
M
Laboratorio di Immunologia, Istituto Superiore di Sanità, Rome, Italy.
Yassen
A
A
Tombesi
M
M
Samoggia
P
P
Barca
S
S
Caserta
M
M
D004351:Drug Resistance / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D012333:RNA, Messenger / Q000032:analysis*; D016201:Receptors, Lymphocyte Homing / Q000235:genetics*; D014407:Tumor Cells, Cultured
D012333:RNA, Messenger; D016201:Receptors, Lymphocyte Homing