Triamcinolone acetonide inhibits lymphocyte differentiation in B cells decorated with artificial antigen receptors.
We examined the effects of triamcinolone acetonide (TA) on T cell independent antigen-induced differentiation of human B cells. Purified human B cells artificially decorated with palmitate-conjugated monoclonal IgA antibody specific for 2,4-dinitrophenyl differentiated polyclonally when challenged with optimum concentrations of dinitrophenyl-derivatized polymerized flagellin. This B cell response was reduced by the synthetic corticosteroid TA at a concentration of 10(-6) M. This suggests that TA can inhibit in vitro B lymphocyte differentiation independent of T cells.
Department of Physiology, Colorado State University, Ft. Collins 80523.
D A
DA
Roess
M E
ME
Zschokke
J S
JS
Peacock
B G
BG
Barisas
D019297:2,4-Dinitrophenol; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000942:Antigens, Bacterial; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D004140:Dinitrophenols / Q000494:pharmacology; D005408:Flagellin / Q000276:immunology / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D012475:Salmonella; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D004140:Dinitrophenols; D005408:Flagellin; D014222:Triamcinolone Acetonide; D019297:2,4-Dinitrophenol