Spectrophotometric determination of hydralazine with 2-hydroxy-1-naphthaldehyde in pharmaceuticals.
A new extraction-spectrophotometric method for the determination of hydralazine, based on its reaction with 2-hydroxy-1-naphthaldehyde at 25 degrees C, is described. The calibration curve was linear between 0.4 and 6 mg/mL of hydralazine. The molar absorbtivity of the product at 408 nm is 40,900 L.mol-1.cm-1. The method described was applied to the analysis of hydralazine in pharmaceutical preparations containing reserpine, hydrochlorothiazide, bendrofluorthiazine, propranolol, and other substances. The agreement with the U.S.P. XXI method was satisfactory for tablets and injections, but not for pellets.
Laboratory of Chemistry-Physics and Toxicology, Facultat de Farmacia, Universitat de Valencia, Spain.
J
J
Mari-Buigues
J
J
Mañes-Vinuesa
R
R
Garcia-Domenech
G
G
Pous-Miralles
D006830:Hydralazine / Q000032:analysis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D009281:Naphthalenes / Q000032:analysis* / Q000737:chemistry; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
D007202:Indicators and Reagents; D009281:Naphthalenes; D012997:Solvents; D006830:Hydralazine; C062247:2-hydroxy-1-naphthaldehyde