Insulin acts on the hypothalamic glucose-facilitated neurons to induce hyperglycemia and hyperinsulinemia in the rat.
Microinjection of insulin (0.04-0.12 IU/microliter) into the anterior hypothalamus or the lateral hypothalamus, but not the ventromedial hypothalamus of the rat brain, caused a dose-dependent rise in blood glucose and in serum insulin. The majority (71.5%) of the glucose-facilitated neurons recorded in the lateral hypothalamic area were excited by intracerebral injection of insulin. The data indicate that insulin acts on the hypothalamic glucose-facilitated neurons to induce hyperglycemia and hyperinsulinemia. It is unknown whether insulin normally reaches the hypothalamic area, or how it might do so.
Department of Internal Medicine, Tri-service General Hospital and National Defense Medical Center, Taipei, Taiwan.
L R
LR
Shian
M T
MT
Lin
D000818:Animals; D005947:Glucose / Q000502:physiology*; D006706:Homeostasis; D006943:Hyperglycemia / Q000209:etiology*; D006946:Hyperinsulinism / Q000097:blood / Q000209:etiology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007328:Insulin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008297:Male; D008845:Microinjections; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D005947:Glucose