Suitability of rodent tumor models for experimental PET with L-[1-11C]tyrosine and 2-[18F]fluoro-2-deoxy-D-glucose.
The applicability of five different rodent tumors for experimental PET has been investigated. L-[1-11C]Tyrosine was a better indicator for the growth activity of the tumors than [18F]FDG. For experimental PET, the three mice models studied appeared inappropriate; the Lewis lung tumor and the fibrosarcomateous FIO 26 had too low a tyrosine utilization, while the lymphosarcomateous LY showed insufficient tumor-to-background ratios. Of the two rat models, the necrotic Walker 256 carcinosarcoma was less suitable. By using L-[1-11C]tyrosine, the solid, rhabdomyosarcoma tumor offers good possibilities of monitoring therapeutic interventions with PET.
Department of Nuclear Medicine, University Hospital, Groningen, The Netherlands.
B J
BJ
Daemen
P H
PH
Elsinga
A M
AM
Paans
W
W
Lemstra
A W
AW
Konings
W
W
Vaalburg
D000818:Animals; D002247:Carbon Isotopes; D002279:Carcinoma 256, Walker / Q000000981:diagnostic imaging; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed; D014443:Tyrosine / Q000493:pharmacokinetics
D002247:Carbon Isotopes; D005462:Fluorine Radioisotopes; D011506:Proteins; D019788:Fluorodeoxyglucose F18; D014443:Tyrosine; D003847:Deoxyglucose