Analysis of the polyadenylation consensus sequence context in the genes of nuclear encoded mitochondrial proteins.
A compilation of the pre-mRNA ends of the genes of nuclear encoded mitochondrial proteins resulted in a consensus sequence of the type (T/A)NTTNNNNNTTTNAATAAA. Nucleotide positions +8, +13, +14, +16 and +17 downstream of the AATAAA sequence show also a predominance of nucleotide T. This consensus sequence suggests the importance of the immediate surroundings of the cannonical polyadenylation signal sequence AATAAA on the efficiency of the cleavage and polyadenylation of this specific group of pre-mRNAs.
Laboratorium für Biochemie I, ETH Zentrum, Zürich, Switzerland.
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Juretić
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Theus
D000818:Animals; D001483:Base Sequence; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D008969:Molecular Sequence Data; D009694:Nucleic Acid Precursors / Q000235:genetics; D011061:Poly A / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid; D016415:Sequence Alignment
D009694:Nucleic Acid Precursors; D012333:RNA, Messenger; D011061:Poly A