Alveolar rhabdomyosarcoma with del(13q14).
We report a case of disseminated alveolar rhabdomyosarcoma, where chromosome analysis showed a deletion of chromosome 13(q14). This breakpoint is involved in the t(2;13)(q37;q14) previously reported in cases of rhabdomyosarcoma, but this is the first reported case in whom this deletion occurs without involvement of chromosome 2. The possible oncogenic role of the retinoblastoma (RB1) gene located at the breakpoint is discussed.
Harrison
C J
CJ
North Western Regional Cytogenetics Service (Onocology), Christie Hospital and Holt Radium Institute, Manchester, U.K.
Johnson
P R
PR
Yin
J A
JA
Bhavnani
M
M
D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13; D006801:Humans; D007621:Karyotyping; D008297:Male; D012208:Rhabdomyosarcoma / Q000235:genetics*