Pharmacokinetics of [6]-gingerol after intravenous administration in rats.
A high-performance liquid chromatographic method to determine [6]-gingerol, a pungent constituent of ginger, in rat plasma was developed and a pharmacokinetic study was performed in rats. Quantitative analysis with high reproducibility was achieved for [6]-gingerol over the concentration range of 0.2-40 micrograms/ml. After bolus intravenous administration at a dose of 3 mg/kg, the plasma concentration-time curve was described by a two-compartment open model. [6]-Gingerol was rapidly cleared from plasma with a terminal half-life of 7.23 min and a total body clearance of 16.8 ml/min/kg. Serum protein binding of [6]-gingerol was 92.4%.
Department of Pharmacy, Shimane Medical University Hospital, Japan.
G H
GH
Ding
K
K
Naora
M
M
Hayashibara
Y
Y
Katagiri
Y
Y
Kano
K
K
Iwamoto
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002396:Catechols; D005233:Fatty Alcohols / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains
D001798:Blood Proteins; D002396:Catechols; D005233:Fatty Alcohols; C007845:gingerol