Interaction of dexamethasone with phenytoin.
Phenytoin and dexamethasone are frequently administered concurrently to prevent consequences of central nervous system pathology. Limited and conflicting data are available regarding an interaction between the agents. A patient receiving dexamethasone required a daily phenytoin dose of greater than 10 mg/kg to maintain the phenytoin serum concentration within the usual therapeutic range. The concentration increased by nearly 300% after dexamethasone was discontinued.
Lackner
T E
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Department of Clinical Pharmacy, St. Louis College of Pharmacy, Missouri.
D000230:Adenocarcinoma / Q000150:complications / Q000556:secondary; D001929:Brain Edema / Q000188:drug therapy; D001932:Brain Neoplasms / Q000150:complications / Q000556:secondary; D003907:Dexamethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D012640:Seizures / Q000517:prevention & control
D010672:Phenytoin; D003907:Dexamethasone