The reversal of the ischemic effects of epinephrine on a finger with local injections of phentolamine.
The use of phentolamine (Regitine) as a specific competitive antagonist of epinephrine by virtue of its alpha-blocking properties is well known. Its use via digital nerve block infiltration has been described in cases of IV infiltration of sympathomimetics. We discuss a recent case of local and direct infiltration of phentolamine along the course of the digital arteries and directly into the thumb tuft to reverse the local ischemic effects of epinephrine.
Emergency Medical Services, Denver General Hospital, CO 80204-4507.
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Markovchick
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Burkhart
D000328:Adult; D004837:Epinephrine / Q000633:toxicity*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000139:chemically induced*; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013933:Thumb / Q000098:blood supply / Q000293:injuries*; D014664:Vasodilation / Q000187:drug effects; D014950:Wounds, Penetrating / Q000150:complications*
D004837:Epinephrine; D010646:Phentolamine