Stimulatory action of calcium L-threonate on ascorbic acid uptake by a human T-lymphoma cell line.
The effects of preincubation of human T-lymphoma cells with increasing concentrations of calcium L-threonate on the uptake of L-[1-14C]ascorbic acid were examined. Calcium L-threonate (0-1,000 mg%) stimulated ascorbic acid (1.25 mg%) uptake in a dose-dependent manner. These results indicate that calcium threonate and possibly other ascorbic acid metabolites have biological activity and potential pharmacological applications.
Department of Pharmacology, University of Mississippi School of Pharmacy, University 38677.
M J
MJ
Fay
A J
AJ
Verlangieri
D000704:Analysis of Variance; D001205:Ascorbic Acid / Q000493:pharmacokinetics*; D002087:Butyrates / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016399:Lymphoma, T-Cell / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000378:metabolism
D002087:Butyrates; C011369:threonic acid; D001205:Ascorbic Acid