Oral bioavailability of chromium from a specific site.
Analysis of soil from a specific site in New Jersey indicated a low level of sodium and chromium present as a calcium compound. Chromium was then administered orally to young, mature male rats at a level of 240 micrograms/kg for 14 days as chromium-contaminated soil, as CaCrO4, and as an equimolar mixture of the soil and calcium salts for 14 days. The rats were sacrificed 24 hr after the last dosing, and tissues were taken immediately for chromium analysis. Blood, muscle, and liver contained the highest levels of chromium in these animals, although kidney contained the highest concentration per gram of tissue. The total amount of chromium in the tissues was less than 2% of the administered chromium. In a study of the excretion of chromium, the animals were dosed orally for 8 days (with CaCrO4 or contaminated soil, each at the level of 240 mumole Cr/kg), and the chromium in feces and urine was determined on days 1, 2, 7, and 8. After cessation of dosing for 27 days, the same rats were dosed for 2 days at the same level, and chromium in urine and feces was determined for the 2 days. The animals administered the chromium in soil had higher levels of chromium in both urine and feces on all days compared to the group fed the CaCrO4. The total recovery of chromium in any of the 2-day periods was less than 50% of the chromium administered during that period.
Joint Graduate Program in Toxicology, Rutgers University, Piscataway, NJ 08855-0789.
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Witmer
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Harris
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Shupack
D000284:Administration, Oral; D000327:Adsorption; D000818:Animals; D001682:Biological Availability; D002857:Chromium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015386:Hazardous Substances / Q000032:analysis; D006256:Hazardous Waste / Q000032:analysis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012989:Soil Pollutants / Q000032:analysis; D014018:Tissue Distribution
D015386:Hazardous Substances; D006256:Hazardous Waste; D012989:Soil Pollutants; D002857:Chromium