Antibody responses to in vitro translation products following albendazole therapy for Echinococcus granulosus.
Immunoprecipitation of antigens translated in vitro from Echinococcus granulosus RNA revealed that albendazole treatment of human hydatidosis induced antibodies to previously undetectable antigens and that the response to most antigens was specific, although cross-reactivity was observed between Schistosoma mansoni and E. granulosus antisera for two proteins.
Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
R E
RE
Blanton
G B
GB
Okelo
J
J
Kijobe
C H
CH
King
D000328:Adult; D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000918:Antibody Specificity / Q000276:immunology; D000947:Antigens, Helminth / Q000235:genetics / Q000276:immunology*; D002417:Cattle; D003429:Cross Reactions / Q000276:immunology; D004444:Echinococcosis, Hepatic / Q000097:blood / Q000276:immunology*; D004446:Echinococcus / Q000235:genetics; D015801:Helminth Proteins / Q000235:genetics / Q000276:immunology*; D006386:Hemagglutination Tests; D006801:Humans; D015151:Immunoblotting; D014178:Translocation, Genetic / Q000235:genetics
D000947:Antigens, Helminth; D015801:Helminth Proteins; D015766:Albendazole