Lipophilic 99mTc-nitride radiopharmaceuticals as potential myocardial imaging agents.
Monocationic 99mTc-nitrido complexes of a variety of diphosphine ligands have been prepared and the in vivo distribution of such cations has been examined in Sprague-Dawley rats. These complexes show initially high myocardial uptake with subsequent wash-out in this animal model. The lack of myocardial retention can be attributed to the facile in vivo reduction of these cations.
Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, Colchester, England.
J R
JR
Dilworth
C M
CM
Archer
I A
IA
Latham
J D
JD
Kelly
D V
DV
Griffiths
D C
DC
York
P M
PM
Mahoney
B
B
Higley
D000818:Animals; D002855:Chromatography, Thin Layer; D006321:Heart / Q000000981:diagnostic imaging*; D008024:Ligands; D008055:Lipids / Q000737:chemistry; D008297:Male; D015609:Organotechnetium Compounds; D010720:Phosphines; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D008024:Ligands; D008055:Lipids; D015609:Organotechnetium Compounds; D010720:Phosphines