Anomalous gene expression in Alzheimer disease: cause or effect.
Altered chromatin conformation and increased amounts of aluminum have been observed in the brains of patients with Alzheimer disease. These factors have been shown to affect gene regulation. In this report, we describe how these changes may selectively alter the pool size of the human light chain neurofilament gene and play a fundamental role in the expression of this disease.
Centre for Research in Neurodegenerative Disease, University of Toronto, Canada.
D R
DR
McLachlan
W J
WJ
Lukiw
C
C
Mizzen
M E
ME
Percy
M J
MJ
Somerville
M K
MK
Sutherland
L
L
Wong
D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D000704:Analysis of Variance; D002540:Cerebral Cortex / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D015536:Down-Regulation / Q000235:genetics; D015870:Gene Expression; D006657:Histones / Q000378:metabolism; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism
D002843:Chromatin; D006657:Histones; D012333:RNA, Messenger