Comparison of dermal and systemic application of glucocorticoids on the RM 3/1+ macrophage in human blood.
Dermal administration of either hydrocortisone or fluprednidene to healthy skin causes only a weak and short-lasting increase of the proportion of the anti-inflammatory macrophage RM 3/1 in the blood compared to the effect of the systemic application of glucocorticoids on this cell subtype. On the other hand, a rather permanent increase of these macrophages could be observed in untreated patients suffering from certain skin diseases, e.g. urticaria, atopic dermatitis, psoriasis.
Institute of Pharmacology, Medical Faculty, RWTH Aachen, FRG.
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Zwadlo-Klarwasser
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Bent
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Schmutzler
D000279:Administration, Cutaneous; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000187:drug effects*
D000305:Adrenal Cortex Hormones