Significance of mildly elevated creatine kinase (myocardial band) activity after elective abdominal aortic aneurysmectomy.
The clinical significance of mildly elevated creatine kinase (CK) myocardial band (MB) enzyme levels in patients undergoing elective repair of an abdominal aortic aneurysm was evaluated retrospectively in 348 patients. For each patient, preoperative and postoperative electrocardiograms (ECGs) were interpreted blindly for left ventricular hypertrophy, ST segment abnormality, left bundle branch block, right bundle branch block, left axis deviation, atrial fibrillation, T wave abnormality, and Q waves. A total of 107 patients (31%) had postoperative CK-MB elevations of trace or greater; 37 had trace, 35 had 1% to 4%, and 35 had greater than or equal to 5% elevation. There was no difference in survival between those with trace and no CK-MB elevation. Patients with increased CK-MB (greater than or equal to 1%) values were more likely to have ECG abnormalities. The following ECG (either preoperative or postoperative) abnormalities were univariately related to decreased postoperative survival: left ventricular hypertrophy (P less than 0.001), ST segment abnormalities (P less than 0.001), left bundle branch block (P less than 0.001), the combination of right bundle branch block and left axis deviation (P = 0.006), Q wave infarction (P less than 0.001), and atrial fibrillation (P less than 0.001). There were 15 in-hospital deaths, and 333 patients were discharged and followed-up for a median of 4.6 years. There were 97 posthospitalization deaths, 61% of which were due to cardiac causes. Overall survival was associated with the degree of CK-MB elevation; the higher the CK-MB, the worse the survival.(ABSTRACT TRUNCATED AT 250 WORDS)
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905.
S R
SR
Rettke
C
C
Shub
J M
JM
Naessens
H M
HM
Marsh
J F
JF
O'Brien
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000777:Anesthetics; D001012:Aorta, Abdominal; D001014:Aortic Aneurysm / Q000201:enzymology / Q000453:epidemiology / Q000601:surgery*; D003402:Creatine Kinase / Q000378:metabolism*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000201:enzymology* / Q000453:epidemiology / Q000401:mortality; D012189:Retrospective Studies; D015996:Survival Rate
D000777:Anesthetics; D007527:Isoenzymes; D003402:Creatine Kinase