IgG4 autoantibodies to DNA in systemic lupus erythematosus patients.
The presence of DNA-specific IgG4 antibodies was demonstrated in the sera of patients with systemic lupus erythematosus (SLE) by a microtiter solid-phase radioimmunoassay. A patient with distal interphalangeal swelling and extensive ulcers in the oral cavity, seronegative for anti-DNA antibodies of the IgG isotype, was found to have anti-DNA autoantibodies exclusively of the IgG4 subclass. These autoantibodies directed against the dsDNA conformation cross-reacted with chondroitin sulfate, dermatan sulfate and heparin.
Department of Biochemistry, Indian Institute of Science, Bangalore.
S
S
Nagpal
M S
MS
Namboodiri
B S
BS
Rao
P V
PV
Rao
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D004247:DNA / Q000276:immunology*; D004277:DNA, Single-Stranded / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000276:immunology; D011863:Radioimmunoassay; D011897:Random Allocation; D014456:Ulcer / Q000276:immunology
D000974:Antibodies, Antinuclear; D004277:DNA, Single-Stranded; D007074:Immunoglobulin G; D004247:DNA