[Experimental development of carcinoma in rats caused by N-nitrosopiperidine with vitamin C].
In animal experiments with Wistar rats we attempted to determine if oral application of Vitamin C inhibits or delays carcinogenesis due to oral administered N-Nitrosopiperidine (NTP). One group of animals received NTP only, two other groups NTP and Vitamin C either alternating or simultaneously. A fourth group receiving only Vitamin C served as control. Carcinomas of the esophagus, stomach and liver developed in response to NTP application. The additional administration of Vitamin C neither inhibited nor delayed the development of carcinomas.
Chirurgische Klinik und Poliklinik, Universität Erlangen--Nürnberg.
H
H
Kessler
B
B
Husemann
W
W
Wagner
B
B
Lowies
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000517:prevention & control*; D009602:Nitrosamines / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D009602:Nitrosamines; C002743:N-nitrosopiperidine; D001205:Ascorbic Acid
Experimentelle Karzinomentstehung bei Ratten durch N-Nitrosopiperidin unter Einwirkung von Vitamin C.