The EURODEM collaborative re-analysis of case-control studies of Alzheimer's disease: implications for clinical research and practice.
The EURODEM re-analyses of 11 case-control studies of Alzheimer's disease imply that familial aggregation of dementia, Down's syndrome, and parkinsonism occurs more frequently in Alzheimer's disease than in matched controls. Prior history of head trauma, hypothyroidism, and depression also occurs in higher frequency among patients with Alzheimer's disease. Exposure to a series of other medical conditions and environmental toxins was not significant. The association between Alzheimer's disease and maternal age remains unclear.
Kokmen
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Department of Neurology, Mayo Clinic, Rochester, MN 55905.
D000544:Alzheimer Disease / Q000453:epidemiology*; D001315:Australia / Q000453:epidemiology; D016022:Case-Control Studies; D005060:Europe / Q000453:epidemiology; D006801:Humans; D012106:Research; D014481:United States / Q000453:epidemiology