AIDS and rheumatic manifestations in patients addicted to drugs. An analysis of 106 cases.
We evaluated the rheumatic manifestations in 106 patients with AIDS whose risk factor is intravenous drug addiction. All were intravenous drug addicts and carriers of the human immunodeficiency virus (HIV). Their average age was 28.36 years; 83 were men and 23 were women; 73 were in stage IV of the HIV infection; 12 were in stage III and 21 in stage II. Rheumatic manifestations were found in 21 patients (20%). Specifically, 13 had arthralgias/myalgias, 2 demonstrated oligoarthritis, 1 had tuberculous arthritis of the knee, and 1 patient showed systemic necrotizing vasculitis. Finally, 6 patients had a history of septic arthritis. There was an absence of the Reiter syndrome/reactive arthritis, a low frequency of symptoms of articular swelling, and the marked presence of histories of septic arthritis. The practices that lead to HIV infection may play a decisive role in the appearance of rheumatic manifestations in patients with AIDS, even more than the presence of the virus itself or the immunological alterations thereby produced.
Monteagudo
I
I
Servicio de Reumatologia, Hospital Gregorio Marañon, Madrid, Spain.
Rivera
J
J
Lopez-Longo
J
J
Cosin
J
J
Garcia-Monforte
A
A
Carreño
L
L
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000209:etiology; D005260:Female; D015796:HLA-B27 Antigen / Q000032:analysis; D006801:Humans; D008297:Male; D015995:Prevalence; D012216:Rheumatic Diseases / Q000139:chemically induced / Q000150:complications* / Q000188:drug therapy; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000150:complications*; D015215:Zidovudine / Q000009:adverse effects / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015796:HLA-B27 Antigen; D015215:Zidovudine