Effect of systemic doxycycline administration on the subgingival microbial flora: a dark-field microscopy study.
The effect of systemically administered doxycycline hydrochloride on subgingival microbial plaque morphotypes was evaluated using dark-field microscopy. After 1 week of drug administration, while the percentage of coccoid bacteria showed a significant increase, the percentages of spirochetes, motile rods and non-motile rods tended to decrease. Since spirochetes and/or motile rods are considered to be associated with the pathogenesis of periodontal disease, the significant decrease in the proportions of these bacteria are considered to be important. Therefore, it is suggested that doxycycline may be beneficial for the treatment of periodontal disease as an adjunct to traditional therapeutic methods.
Department of Periodontology, Faculty of Dentistry, University of Hacettepe-Ankara, Turkey.
N
N
Yamalik
F
F
Tunçkanat
T
T
Ataoglu
D
D
Sengün
D000328:Adult; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D003773:Dental Plaque / Q000382:microbiology* / Q000517:prevention & control; D003774:Dental Plaque Index; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D005881:Gingiva / Q000382:microbiology*; D006801:Humans; D008853:Microscopy / Q000379:methods; D010510:Periodontal Diseases / Q000382:microbiology / Q000517:prevention & control; D010512:Periodontal Index; D013144:Spirochaetales / Q000187:drug effects
D004318:Doxycycline