Two cases of multiple sclerosis with painful tonic seizures and dysesthesia ameliorated by the administration of mexiletine.
Mexiletine was administered in two patients suffering from multiple sclerosis with severe dysesthesia and painful tonic seizures. In both patients the painful tonic seizures disappeared and dysesthesia improved as well. The effects of mexiletine on painful symptoms have been previously reported in diabetic neuropathy, but not in diseases of the central nervous system.
Okada
S
S
The Fourth Department of Medicine, School of Medicine, Toho University, Tokyo, Japan.
Kinoshita
M
M
Fujioka
T
T
Yoshimura
M
M
D005260:Female; D006801:Humans; D008801:Mexiletine / Q000627:therapeutic use*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D009422:Nervous System Diseases / Q000150:complications / Q000188:drug therapy; D010146:Pain / Q000150:complications / Q000188:drug therapy; D012640:Seizures / Q000150:complications / Q000188:drug therapy; D012677:Sensation
D008801:Mexiletine