[Production of human antimurine antibody after in vivo use of radioisotope labelled murine antibodies].
In vivo employment of monoclonal antibodies of murine origin (MoAb) with the object of immunotherapy or immunoscintigraphy may result in formation of human antimouse antibodies (HAMA) in a number of the persons exposed. HAMA is of IgG and also IgM types. Allergic reactions may occur but only few are of serious nature (less than 0.3 per thousand). In cases where MoAb is administered on repeated occasions, HAMA forms complexes with the injected which results in resuced quality of immunescintigraphic examinations, increased clearance of MoAb and reduced effect of immunetherapy. "Sandwich" type of immune analyses on blood samples which contain HAMA must be planned so that HAMA interference is eliminated.
Afdelingen for klinisk fysiologi og nuklearmedicin, Rigshospitalet, København.
J C
JC
Toft
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N
Tromholt
D000818:Animals; D000910:Antibodies, Heterophile / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D007553:Isotope Labeling; D051379:Mice
D000910:Antibodies, Heterophile; D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Produktion af humant antimurint antistof efter in vivo anvendelse af radioaktivt maerkede murine antistoffer.