Palladium, platinum, cadmium, and mercury complexes with neutral isoorotic and 2-thioisoorotic acids: IR and NMR spectroscopies, thermal behavior and biological properties.
Seven complexes containing neutral isoorotic and 2-thioisoorotic acids, as well as thiocyanate and chloride anions as lignands, have been synthesized and characterized by means of both spectral (IR, 1H, and 13C NMR) and thermal (TG and DSC) methods, as well as conductivity measurements. Spectral data suggest that any binding metal-ligand mode for uracil derivatives is not easy to propose. Therefore, isoorotic ligands must link through some oxygen atom. Likewise, 2-thioisoorotic acid seems to be [N,S] bonded in Pd(II) and Pt(IV) complexes, whereas for Hg(II) complex a distorted tetrahedral HgCl2S2 structure has been proposed. In the cadmium complex, the metal ion exhibits a CdCl2O2 coordination sphere. Antimicrobial activities of the complexes against Pseudomonas sp, E. coli, Proteus sp, Salmonella sp, Micrococcus sp, Staphylococcus sp, Bacillus sp and Candida sp were performed as a previous step in the study of their biological activity.
Facultad de Ciencias Experimentales de Jaén, Universidad de Granada, Spain.
F
F
Hueso-Ureña
M N
MN
Moreno-Carretero
J M
JM
Salas-Peregrín
G
G
Alvarez de Cienfuegos-López
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D002104:Cadmium / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008628:Mercury / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009963:Orotic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D009942:Organometallic Compounds; D009944:Organoplatinum Compounds; D002104:Cadmium; D010165:Palladium; D009963:Orotic Acid; D008628:Mercury