Comparative acute ototoxicity of loop diuretic compounds.
A microelectrode was used to measure endocochlear potentials (EP) in adult chinchillas and to study the effects of a series of loop diuretics. EP was measured before, during and for several hours after the intravenous injection of the following loop diuretics: furosemide, piretanide, bumetanide, ethacrynic acid, indacrinone stereoisomers and ozolinone. The first four loop diuretics caused a substantial dose-related reduction of EP. The (-) isomer of indacrinone was found to cause a dose-related reduction of EP to a moderate degree. The (+) isomer of indacrinone and ozolinone caused very little change of EP, even in very high doses. Findings are consistent with data on the mechanism of action of these agents in the kidney.
Department of Surgery, Southern Illinois University School of Medicine, Springfield 62794-9230.
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Rybak
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Whitworth
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D000208:Acute Disease; D000818:Animals; D002034:Bumetanide / Q000008:administration & dosage / Q000633:toxicity; D002682:Chinchilla; D003051:Cochlea / Q000187:drug effects*; D004232:Diuretics / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004976:Ethacrynic Acid / Q000008:administration & dosage / Q000633:toxicity; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005665:Furosemide / Q000008:administration & dosage / Q000633:toxicity; D007189:Indans / Q000008:administration & dosage / Q000633:toxicity; D013237:Stereoisomerism; D013449:Sulfonamides / Q000008:administration & dosage / Q000633:toxicity; D013844:Thiazoles / Q000008:administration & dosage / Q000633:toxicity; D013997:Time Factors
D004232:Diuretics; D007189:Indans; D013449:Sulfonamides; D013844:Thiazoles; D002034:Bumetanide; C018121:ozolinone; D005665:Furosemide; C013352:indacrinone; C015451:piretanide; D004976:Ethacrynic Acid