[Remarkable improvement of anemia by administration of recombinant human erythropoietin in a patient with aplastic anemia].
A 69-year-old female was admitted for pancytopenia. The hematological examination showed leukocytes 1,800/microliters, hemoglobin 5.3 g/dl and platelets 9.6 x 10(4)/microliters. A bone marrow aspiration revealed hypoplasia, but no abnormal cells. Serum erythropoietin titer was 5,100 mU/ml. Diagnosis of aplastic anemia was made. She received 400 ml of blood transfusion twice, and was then treated with recombinant human erythropoietin (rHuEPO) (12,000 U/day) three times a week for eight weeks. Hemoglobin level gradually increased to the level of 12.0 g/dl. This case suggests that there are some cases of aplastic anemia which can respond to treatment with rHuEPO.
First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health.
M
M
Misago
N
N
Mori
T
T
Hoshuyama
J
J
Tsukada
I
I
Morimoto
S
S
Oda
S
S
Chiba
S
S
Eto
D000368:Aged; D000741:Anemia, Aplastic / Q000628:therapy*; D004334:Drug Administration Schedule; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use
D011994:Recombinant Proteins; D004921:Erythropoietin