Thyrotoxic periodic paralysis complicated with primary aldosteronism.
A 35-year-old man presented with acute onset of bilateral lower extremity weakness after ingesting a large amount of carbohydrates. Laboratory investigation revealed severe hypokalemia (1.9 mEq/l) and hyperthyroidism. The patient also exhibited primary aldosteronism due to a left adrenal adenoma. As a diagnostic tool, paralysis with hypokalemia (2.8 mEq/l) was induced with a glucose infusion. After treatment with methimazole, there were no further episodes of paralysis and subsequent induction of paralysis with glucose was impossible, though primary aldosteronism persisted. These findings indicate that hyperthyroidism played a major role in the development of periodic paralysis, while primary aldosteronism apparently increased the patient's vulnerability to paralytic attacks.
Yokota
N
N
First Department of Internal Medicine, Miyazaki Medical College, Japan.
Uchida
T
T
Sasaki
A
A
Kobayashi
K
K
Kida
O
O
Yamamoto
Y
Y
Eto
T
T
Tanaka
K
K
D000236:Adenoma / Q000150:complications / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000601:surgery; D000328:Adult; D004040:Dietary Carbohydrates / Q000009:adverse effects; D005947:Glucose; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000601:surgery; D007008:Hypokalemia / Q000209:etiology; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D010243:Paralysis / Q000453:epidemiology / Q000209:etiology*; D013971:Thyrotoxicosis / Q000150:complications* / Q000188:drug therapy
D004040:Dietary Carbohydrates; D008713:Methimazole; D005947:Glucose