Construction of kinetic models to understand metabolism in vivo.
This review describes increasingly complex kinetic models that simulate carbohydrate metabolism in a simple eucaryotic system which undergoes differentiation. Dynamic models of complex metabolic networks serve to organize and analyze the many interdependent variables involves and to define the rate-limiting events controlling metabolism in vivo. Since the ultimate justification for and test of any model are its predictive values, a series of predictions and related experiments will be described.
Wright
B E
BE
Division of Biological Sciences, University of Montana, Missoula 59812.
D050260:Carbohydrate Metabolism; D002851:Chromatography, High Pressure Liquid; D004023:Dictyostelium / Q000201:enzymology*; D007700:Kinetics; D008956:Models, Chemical