Mechanism for pressor response to nonexertional heating in the conscious rat.
The purpose of this study was to determine the systemic hemodynamic mechanism(s) underlying the pressor response to nonexertional heat stress in the unrestrained conscious rat. After a 60-min control period [ambient temperature (Ta) 24 degrees C], male Sprague-Dawley rats (260-340 g) were exposed to a Ta of 42 degrees C until a colonic temperature (Tc) of 41 degrees C was attained. As Tc rose from control levels (38.1 +/- 0.1 degrees C) to 41 degrees C, mean arterial blood pressure (carotid artery catheter, n = 33) increased from 124 +/- 2 to 151 +/- 2 mmHg (P less than 0.05). During this period, heart rate increased (395 +/- 5 to 430 +/- 6 beats/min, P less than 0.05) and stroke volume remained unchanged. As a result, ascending aorta blood flow velocity (Doppler flow probe, n = 8), used as an index of cardiac output, did not change from control levels during heating, but there was a progressive Tc-dependent increase in systemic vascular resistance (+30% at end heating, P less than 0.05). This systemic vasoconstrictor response was associated with decreases in blood flow (-31 +/- 9 and -21 +/- 5%) and increases in vascular resistance (94 +/- 16 and 53 +/- 8%; all P less than 0.05) in the superior mesenteric and renal arteries (n = 8 each) and increases in plasma norepinephrine (303 +/- 37 to 1,237 +/- 262 pg/ml) and epinephrine (148 +/- 28 to 708 +/- 145 pg/ml) concentrations (n = 12, P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Kregel
K C
KC
Department of Exercise and Sport Sciences, University of Arizona, Tucson 85721.
Overton
J M
JM
Johnson
D G
DG
Tipton
C M
CM
Seals
D R
DR
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D001831:Body Temperature / Q000502:physiology; D002395:Catecholamines / Q000097:blood; D004837:Epinephrine / Q000097:blood; D006339:Heart Rate / Q000502:physiology; D006358:Hot Temperature; D008297:Male; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000502:physiology; D013152:Splanchnic Circulation / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology
D002395:Catecholamines; D009638:Norepinephrine; D004837:Epinephrine