Change in pattern of muscle activity following botulinum toxin injections for torticollis.
Twenty patients with torticollis had electromyographic studies of their neck muscles performed before and after a series of local injections of botulinum toxin. The pattern of muscle activity changed after the injections, and this effect persisted even after head position had returned to baseline. Patients who did not experience any clinical benefit from the injections also demonstrated a change in the pattern of muscle activity. These results suggest that the underlying abnormality in torticollis usually involves a general motor program for head position, rather than the activity of individual neck muscles.
Department of Neurology, University of Michigan, Ann Arbor, CA 48109-0316.
D J
DJ
Gelb
D M
DM
Yoshimura
R K
RK
Olney
D H
DH
Lowenstein
M J
MJ
Aminoff
D000328:Adult; D000368:Aged; D001905:Botulinum Toxins / Q000008:administration & dosage* / Q000494:pharmacology; D004334:Drug Administration Schedule; D004576:Electromyography / Q000187:drug effects; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009334:Neck Muscles / Q000187:drug effects* / Q000502:physiology; D014103:Torticollis / Q000188:drug therapy* / Q000503:physiopathology
D001905:Botulinum Toxins