[Significance of isolated anti-HBs antibodies in subjects not vaccinated against hepatitis B viruses].
The significance of isolated anti-HBs antibodies in subjects not vaccinated against the hepatitis B virus (HBV) was investigated in 13 healthy blood donors. All were European and none had any risk factor for hepatitis B infection. Serological assays included HBV-DNA and anti-preS 2 antibody determinations which were all negative. After injection with hepatitis B vaccine (Hevac B), only one out of the 13 subjects exhibited an anamnestic response in favor of secondary immunization. Neutralization tests for serum anti-HBs antibody were positive in only 6 subjects. Our data suggest that in most cases isolated anti-HBs positivity does not correspond to true antibody; booster injection of HBV vaccine seems to be the best way of verifying that antibodies are really protective.
Service d'Hépato-Gastroentérologie, Hôpital Laennec, Paris.
F
F
Driss
J P
JP
Zarski
A M
AM
Courouce
D
D
Eme
C
C
Brechot
P
P
Berthelot
F
F
Tron
B
B
Nalpas
D000328:Adult; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage*
D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D014761:Viral Hepatitis Vaccines
Signification des anticorps anti-HBs isolés chez des sujets non vaccinés contre le virus de l'hépatite B.