Brahmighritham, an Ayurvedic herbal formula for the control of epilepsy.
Brahmighritham is an Ayurvedic herbal recommended for the control of epilepsy. The preparation of the drug is described. It was tested for its oral effectiveness in controlling pentylenetetrazole-induced seizures in male albino rats and was compared with benzdiazepam. Alterations in the EEG pattern and gross neurological function were measured or rated 60 min after pentylenetetrazole administration. Thirty-day pretreatment with both Brahmighritham and benzdiazepam served to make the rats more insensitive to epileptogenic events.
Department of Biochemistry, University of Madras, Taramani, India.
E R
ER
Shanmugasundaram
G K
GK
Akbar
K R
KR
Shanmugasundaram
D000284:Administration, Oral; D000818:Animals; D003975:Diazepam / Q000627:therapeutic use; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy*; D007274:Injections, Intraperitoneal; D008297:Male; D008515:Medicine, Ayurvedic; D010433:Pentylenetetrazole / Q000633:toxicity; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D010936:Plant Extracts; D003975:Diazepam; D010433:Pentylenetetrazole