Ovarian vein sampling in rapidly progressing virilization. A case report.
A woman presented with progressive hirsutism, deepening of the voice, clitoromegaly and increased libido. The preoperative serum testosterone level was 2,042 ng/dL. The intraoperative ovarian venous blood testosterone levels were 56,327 ng/dL on the left and 1,417 on the right. After a bilateral salpingo-oophorectomy, the serum testosterone level was 20.7 ng/dL. Initial pathologic examination of the ovaries revealed no potential source of testosterone, but reexamination revealed a pure lipoid cell tumor. Intraoperative ovarian vein androgen measurements can be helpful in establishing a histopathologic diagnosis in cases of microscopic virilizing ovarian neoplasms. Ovarian vein sampling for androgen was essential in locating this patient's microscopic tumor.
Department of Obstetrics and Gynecology, Portsmouth Naval Hospital, Virginia.
E A
EA
DeFreitas
M R
MR
Dudzinski
J C
JC
LaRocque
C C
CC
Coddington
D000314:Adrenal Rest Tumor / Q000150:complications / Q000175:diagnosis*; D000328:Adult; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis*; D010052:Ovariectomy; D010053:Ovary / Q000098:blood supply; D013739:Testosterone / Q000097:blood*; D014680:Veins; D014770:Virilism / Q000175:diagnosis* / Q000209:etiology
D013739:Testosterone