Mononuclear cell trafficking and plasma protein extravasation into the CNS during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice.
Cellular traffic and plasma protein extravasation across the blood-brain and blood-spinal cord barrier (BBB) have been studied during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice, using a simultaneous double radioisotope method. There was a general correlation between the clinical course of disease and BBB breakdown, including a resealing of the barrier during remission, although breakdown appeared slightly to precede clinical presentation. The brain was markedly less affected than the spinal cord and was only minimally involved in the relapse phase of disease.
Department of Pathology, Hunterian Institute, Royal College of Surgeons of England, London, U.K.
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Butter
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Baker
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O'Neill
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Turk
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000502:physiology; D002490:Central Nervous System / Q000378:metabolism*; D002860:Chromium Radioisotopes; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009000:Monocytes / Q000502:physiology*; D009161:Mycobacterium / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D012008:Recurrence; D012709:Serum Albumin / Q000378:metabolism; D013116:Spinal Cord / Q000166:cytology / Q000276:immunology
D001798:Blood Proteins; D002860:Chromium Radioisotopes; D007457:Iodine Radioisotopes; D012709:Serum Albumin