[The effect of massive blood loss on the adrenaline-sensitive pool of the blood neutrophils].
Experiments were conducted on models of immobilization stress and hemorrhagic shock in rabbits to study the changes in the ability of intravenously injected adrenaline (A) to induce blood neutrophilia due to the escape of parietal neutrophils into circulation. It is shown that immobilization stress, just like A infusion, leads to neutrophilia. In contrast, in hemorrhagic shock neutropenia develops and the response to A disappears. Such changes in massive blood loss are interpreted by the authors as transition of the marginal (physiological) adhesion of neutrophils in the vascular system to pathological adhesion characteristic of inflammatory reactions.
Iu P
IuP
Iushchenko
V I
VI
Zeliak
S V
SV
Glushen
D000208:Acute Disease; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006470:Hemorrhage / Q000097:blood*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D011817:Rabbits; D012149:Restraint, Physical; D012771:Shock, Hemorrhagic / Q000097:blood; D013997:Time Factors
D004837:Epinephrine
Vliianie massivnoĭ krovopoteri na adrenalinchuvstvitel'nyĭ pul neĭtrofilov krovi.