[An investigation of drug-induced hematologic disorders in Japan--result of Hokkaido].
Patients with drug-induced hematologic disorders were clinically analysed. Fifty-nine cases were registered from 6 hospitals in Hokkaido. These were 21 cases of male and 38 of female. Age-distribution was 18 to 84 years old. Types of hematologic disorders were as follows, 9 cases of pancytopenia, 16 of bicytopenia and 31 of monocytopenia. Leukocytopenia only and leukocytopenia with another disorders were high incidence (85%). Decision of causal drug are done by DLST (drug lymphocyte stimulation test); 5 cases, drug-rechallenge; 3 cases and clinical course only; 31 cases. In 11 fatal cases by this lesion, there included 7 cases of pancytopenia.
Dep. Inntern. Med. Asahikawa City Hospital.
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Maekawa
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006402:Hematologic Diseases / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D010198:Pancytopenia / Q000139:chemically induced