'Antibiobodies': antibiotic-like anti-idiotypic antibodies.
Pathogenic micro-organisms such as Candida albicans may be susceptible to the activity of antimicrobial products like yeast killer toxins due to the presence of specific cell wall receptors for these agents. Anti-idiotypic antibodies (anti-Ids) were produced that competed for these receptors with the yeast killer toxin of a strain of Pichia anomala. We report here that affinity chromatography purified anti-Ids may kill C. albicans cells in vitro which are susceptible to the activity of the yeast killer toxin, as well as P. anomala killer cells which are obviously immune to their own toxin despite possessing specific cell wall receptors which can be detected by indirect immunofluorescence with anti-Ids. We propose that these conceptually new antimicrobial immunoglobulins acting as antibiotics be called 'antibiobodies'.
Polonelli
L
L
Istituto di Microbiologia, Università degli Studi di Parma, Italy.
Conti
S
S
Gerloni
M
M
Magliani
W
W
Castagnola
M
M
Morace
G
G
Chezzi
C
C
D000900:Anti-Bacterial Agents / Q000276:immunology* / Q000302:isolation & purification / Q000494:pharmacology; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology* / Q000302:isolation & purification; D001667:Binding, Competitive; D002846:Chromatography, Affinity; D005455:Fluorescent Antibody Technique; D005656:Fungal Proteins / Q000276:immunology; D055646:Killer Factors, Yeast; D009183:Mycotoxins / Q000276:immunology
D000900:Anti-Bacterial Agents; D000888:Antibodies, Anti-Idiotypic; D005656:Fungal Proteins; D055646:Killer Factors, Yeast; D009183:Mycotoxins