Type IV allergy to amide-type local anesthetics.
The case of a 45-year-old woman is reported, who developed intense erythema and itching 1 day after subcutaneous (s.c.) injection of a local anesthetic containing mepivacaine and methylparaben. The reaction was attributed to a delayed-type sensitivity to mepivacaine, since mepivacaine gave a positive patch test response and also elicited a delayed sensitivity reaction after s.c. challenges, whereas prick and patch tests with methylparaben, as well as oral challenges, were negative. Interestingly, the patient also showed sensitization to lidocaine, a compound to which she had previously also been exposed.
Department of Dermatology, University of Ulm, FRG.
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Klein
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Gall
D000779:Anesthetics, Local / Q000009:adverse effects*; D003429:Cross Reactions / Q000187:drug effects; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D008012:Lidocaine / Q000009:adverse effects / Q000737:chemistry; D008619:Mepivacaine / Q000009:adverse effects; D008875:Middle Aged; D010328:Patch Tests
D000779:Anesthetics, Local; D008012:Lidocaine; D008619:Mepivacaine