The effect of bile juice reflux on the development of remnant stomach carcinoma.
Experimental studies have revealed that duodenogastric reflux subsequent to gastrectomy was one of the most significant factors for the development of carcinoma in the remnant stomach. For this reason, the binding of carcinogenic agents to the nucleic acids in the gastric mucosa exposed to the duodenal contents were studied using an organ culture method. The intracellular DNA levels bound with carcinogenic agents were significantly increased in the mucosa of the remnant stomach, as compared to the parietal mucosa in the whole stomach. The remnant stomach may therefore provide an environment that enhances the development of cancer.
Hashimoto
K
K
Department of Surgery, Kurume University School of Medicine, Japan.
Kakegawa
T
T
Takeda
J
J
Hiraki
Y
Y
Koufuji
K
K
Tanaka
T
T
Yano
S
S
D001655:Bile Reflux / Q000150:complications* / Q000209:etiology; D005743:Gastrectomy / Q000009:adverse effects*; D006801:Humans; D009924:Organ Culture Techniques / Q000295:instrumentation; D013274:Stomach Neoplasms / Q000209:etiology* / Q000503:physiopathology