Pressure-induced striatal dopamine release correlates hyperlocomotor activity in rats exposed to high pressure.
Free-moving rats chronically implanted in the striatum with multifiber carbon electrodes selective to dopamine were compressed in a helium-oxygen mixture to 80 bars. Extracellular dopamine level and behavioral symptoms of high-pressure neurological syndrome were simultaneously recorded. Under these conditions, the extracellular level of dopamine monitored by differential pulse voltammetry was found to be pressure dependent, and hyperlocomotor activity, a behavioral symptom of high-pressure neurological syndrome, was found to be linked to these pressure-induced changes in dopamine release.
Laboratoire de Biologie des Hautes Pressions, Faculté de Médecine Nord, Centre National de la Recherche Scientifique, Unité de Recherche Associée-1330, Marseille, France.
J H
JH
Abraini
J C
JC
Rostain
D000818:Animals; D001274:Atmospheric Pressure; D001522:Behavior, Animal / Q000502:physiology; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004563:Electrochemistry; D004567:Electrodes, Implanted; D006371:Helium; D006610:High Pressure Neurological Syndrome / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009207:Myoclonus / Q000503:physiopathology; D010100:Oxygen; D051381:Rats; D011919:Rats, Inbred Strains; D014202:Tremor / Q000503:physiopathology
D006371:Helium; D010100:Oxygen; D004298:Dopamine