Relationship between the antitussic and analgesic activity of substances.
The authors studied relationship between the antitussic and analgesic activity of substances. The antitussic effect of codeine, tilidine, tramadol and pentazocine has been studied in nonanesthetized healthy cats. The drugs except tilidine, were administered intraperitoneally in a dose of 10 mg/kg body weight. Tilidine was administered intramuscularly in the same dose. Cough induced in nonanesthetized cats by mechanical irritation of laryngopharyngeal and tracheobronchial areas was evaluated by changes of the lateral tracheal pressure. A significant decrease of the subsequent cough parameters was observed after the application of codeine, tilidine, tramadol and pentazocine. Naloxone given 5 min before the application of the drug has not prevented the cough-suppressing effect due to codeine. Naloxone alone administered in a dose of 1 mg/kg body weight has not significantly influenced the experimentally-induced cough reflex in nonanesthetized cats.
Department of Pathophysiology and Pharmacology, Faculty of Medicine, Comenius University, Sklabinská, Czechoslovakia.
G
G
Nosál'ová
A
A
Strapková
J
J
Korpás
D000698:Analgesia; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology*; D002415:Cats; D003061:Codeine / Q000008:administration & dosage / Q000494:pharmacology; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010423:Pentazocine / Q000008:administration & dosage / Q000494:pharmacology; D013993:Tilidine / Q000008:administration & dosage / Q000494:pharmacology; D014147:Tramadol / Q000008:administration & dosage / Q000494:pharmacology
D000700:Analgesics; D000996:Antitussive Agents; D009270:Naloxone; D014147:Tramadol; D013993:Tilidine; D010423:Pentazocine; D003061:Codeine