Long-term treatment effects in patients with bilateral retinoblastoma: ocular and mid-facial findings.
A total of 99 patients with bilateral retinoblastoma who had been treated between 1965 and 1982 were reexamined in April 1988 to study the late effects of treatment. Their median age at the follow-up visit in 1988 was 16 years (range, 6-27 years), and the median follow-up was 15 years (range, 6-26 years). All patients underwent a full eye examination, morphometric measurements of the mid-face and genetic counselling. Each eye or orbit and the corresponding side of the patient's mid-face were evaluated separately, resulting in 198 data sets from 99 individuals. Subjects were divided into four treatment groups according to whether photo- and cryo-coagulation, enucleation, radiation therapy or various combinations thereof were used. In all, 81 eyes had a visual acuity of greater than 0.4 (in 23 of these, however, only with low-vision aids). Within a dose range of 36-51 Gy, the location of the tumor (36%) or cataract (15%) were the main factors responsible for poor visual acuity, whereas radiation retinopathy and/or optic neuropathy occurred in only three cases. Cataracts were more frequently observed following orthovoltage as compared with megavoltage therapy (P = 0.012). A total of 72 eyes had been enucleated and had not received radiation therapy at any time. Cosmetic results (as measured by several parameters) in these cases were significantly better then those in 28 subjects who underwent combined radiation therapy and enucleation. As defined by various subjective as well as objective findings, mid-facial hypoplasia occurred significantly more often following orthovoltage as compared with megavoltage therapy.
Abteilung für Augenheilkunde, Universitätsklinikum, Essen, Federal Republic of Germany.
E P
EP
Messmer
H
H
Fritze
C
C
Mohr
T
T
Heinrich
W
W
Sauerwein
W
W
Havers
B
B
Horsthemke
W
W
Höpping
D000293:Adolescent; D000328:Adult; D001284:Atrophy; D002386:Cataract / Q000209:etiology; D002648:Child; D003131:Combined Modality Therapy; D003452:Cryosurgery; D015353:Eye Enucleation; D005134:Eye Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D005145:Face / Q000473:pathology / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008028:Light Coagulation; D008137:Longitudinal Studies; D008297:Male; D011379:Prognosis; D012175:Retinoblastoma / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies