Mechanism of the cytostasis mediated by blood unstimulated neutrophils on syngeneic rat colon cancer cells.
Non-activated polymorphonuclear neutrophils (PMNs) isolated from the blood of non-stimulated rats were spontaneously and selectively cytostatic in vitro against a syngeneic colon cancer cell line. In this experimental model, the mechanism of PMN-mediated cytostasis did not depend on oxidative metabolites, but involved soluble factor(s), possibly granule proteases.
Research Group on Human and Experimental Digestive Tumours, INSERM U252, Faculty of Medicine, Dijon, France.
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D000818:Animals; D002455:Cell Division; D003110:Colonic Neoplasms / Q000276:immunology*; D010450:Endopeptidases / Q000032:analysis; D005260:Female; D008297:Male; D009245:NADH Dehydrogenase / Q000032:analysis; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology*; D010100:Oxygen / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D014407:Tumor Cells, Cultured
D009245:NADH Dehydrogenase; D010450:Endopeptidases; D010100:Oxygen