The anticonvulsive effect of BCH 325 is age dependent.
The two different experimental approaches which were applied to study the anticonvulsive effectiveness of BCH 325, a des-tyrosine derivative of bovine beta-casomorphin-(5), in immature (22-day-old) and mature (7-week-old) female rats revealed that the peptide was able to protect mature females from electrically induced seizures and that it had no effect on pentylenetetrazol-induced convulsions. As opposed to this, immature animals were protected against chemically induced seizures but no effect was found using electrically induced seizures.
Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, Germany.
A
A
Becker
R
R
Grimm
G
G
Grecksch
H
H
Matthies
D000367:Age Factors; D000818:Animals; D000927:Anticonvulsants; D004597:Electroshock; D004723:Endorphins / Q000494:pharmacology*; D005260:Female; D010433:Pentylenetetrazole; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000517:prevention & control
D000927:Anticonvulsants; D004723:Endorphins; D010446:Peptide Fragments; C059556:beta-casomorphin, des-Tyr-; D010433:Pentylenetetrazole