[High dose 7S-immunoglobulin therapy in collagenoses. Clinical observations and effects on the lymphocyte subsets and immunoglobulin production].
Therapy with 7S-immunoglobulins in 8 patients with various connective tissue diseases led to a decrease of clinical disease activity. In vitro experiments showed that treatment induces change of B-cell function. Significant quantitative alteration of relative lymphocyte subpopulations did not occur. CRP, C3c, C4 and circulating immune complexes tended to normalization.
Städtisches Krankenhaus München-Bogenhausen, Akademisches Lehrkrankenhaus der TU München.
M
M
Mogk
H
H
Zmierczak
R
R
Wiest
M
M
Brückel
H J
HJ
Hatz
K
K
Helmke
D001172:Arthritis, Rheumatoid / Q000628:therapy*; D001327:Autoimmune Diseases / Q000628:therapy*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage; D008180:Lupus Erythematosus, Systemic / Q000628:therapy*; D016131:Lymphocyte Subsets / Q000276:immunology; D014657:Vasculitis / Q000628:therapy*
D007136:Immunoglobulins
Hochdosierte 7S-Immunglobulintherapie bei Kollagenosen. Klinische Beobachtungen und Effekte auf Lymphozytensubpopulationen und Immunglobulinproduktion.