[The role of the autonomic nervous system in the mechanisms regulating hemopoiesis in stress].
It was demonstrated in experiments on rats that a neuroleptic and alpha-adrenergic blocking agent inhibited whereas a ganglion blocking agent and beta-adrenergic blocking agent delayed activation of granulocytopoiesis in immobilization stress, while M-cholinergic blocking agent had practically no effect on this process. Blockade of alpha- or beta-adrenergic receptors causes an essential reduction in the number of hematopoietic islets, precursor cells of granulocytopoiesis in the bone marrow, and level of colony stimulating activity in blood serum and supernatants of lipopolysaccharides and concanavalin-A stimulated myelokaryocytes. However, in immobilization stress the initiator and potentiator effect of stimulation of beta-adrenergic blocking agents on processes of granulocytopoiesis was much less marked than that of alpha-adrenergic blocking agents stimulation.
Gol'dberg cED
A M
AM
Dygaĭ
I A
IA
Khlusov
V P
VP
Shakhov
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*
Rol' vegetativnoĭ nervnoĭ sistemy v mekhanizmakh reguliatsii gempoéza pri stresse.