Lupus anticoagulant as a marker of autoimmunity in recurrent pregnancy loss; a case report.
We present a patient with primary antiphospholipid syndrome, as defined by nine pregnancy losses, the presence of lupus anticoagulant (LAC), and the absence of clinical signs and symptoms of autoimmunity. A successful pregnancy was achieved by treatment with low-dose prednisone (15 mg daily) and aspirin (100 mg daily). The patient was followed-up throughout her two last pregnancies and a 6 months postpartum period. Our data indicate that LAC serves as a marker of disease in women with previous pregnancy wastages, and that aspirin-prednisone therapy is beneficial in carefully selected patients.
Department of Obstetrics and Gynecology, Faculty of Medicine, Hospital Clinic i Provincial, Barcelona, Spain.
J
J
Balasch
A
A
López-Soto
J
J
Font
B
B
Puerto
D000026:Abortion, Habitual / Q000209:etiology*; D000328:Adult; D015551:Autoimmunity; D015415:Biomarkers; D002308:Cardiolipins / Q000276:immunology; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000032:analysis*; D011247:Pregnancy
D015415:Biomarkers; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor