Guanidination of a peptide side chain amino group on a solid support.
A novel guanidination method of converting a peptide side chain amino group to a guanidino group on a solid support is described. Four guanidinating reagents were evaluated using a model tetrapeptide attached to a polystyrene resin. Experimental data indicate that the two nitroguanidinating reagents, but not the two tosylguanidinating reagents, can be used effectively in solid phase peptide synthesis.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis.
Z P
ZP
Tian
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Roeske
D001559:Benzhydryl Compounds / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006146:Guanidines / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009587:Nitrogen Isotopes; D009952:Ornithine / Q000138:chemical synthesis; D010455:Peptides / Q000138:chemical synthesis*
D001559:Benzhydryl Compounds; D006146:Guanidines; D009587:Nitrogen Isotopes; D010455:Peptides; C070954:4-methylbenzhydrylamine; D009952:Ornithine