[The action of amtizol and gutimin on the respiratory metabolism of the neuron].
The effects of antihypoxants gutimine and amtisole on oxygen consumption by the intact nerve cell of the invertebrate and the activity of NADN-DH and SDH-dependent ways of oxidation in the cell were studied. Under normoxia gutimine inhibited the nerve cell respiration and decreased the activity of NADN-DN and SDH-dependent ways of oxidation by 15% and 5% respectively. Amtisole activated the neuron respiration increasing the activity of NADN-DH-dependent way of oxidation. Both antihypoxants, despite the fact that they refer to the same class of compounds, have different mechanisms of action on the neuron metabolism. Gutimine appears to be a pharmacological agent, protector, amtisole as an initiator of the active adaptative reorganization of the intracellular metabolism.
S S
SS
Sergeeva
I N
IN
Ianvareva
O Iu
OIu
Uriupov
A B
AB
Tomchin
D000818:Animals; D015687:Cell Hypoxia / Q000187:drug effects / Q000502:physiology; D006164:Guanylthiourea / Q000494:pharmacology*; D007865:Leeches; D009245:NADH Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D010313:Partial Pressure; D013385:Succinate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D013830:Thiadiazoles
D009292:Narcotic Antagonists; D013830:Thiadiazoles; C044365:amtizol; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase; D006164:Guanylthiourea
Deĭstvie amtizola i gutimina na dykhatel'nyĭ metabolizm neĭrona.