Predictive value of the fluorescent cytoprint assay (FCA): a retrospective correlation study of in vitro chemosensitivity and individual responses to chemotherapy.
The potential clinical usefulness of the fluorescent cytoprint assay (FCA) was assessed retrospectively in 73 cancer patients by correlating individual tumor chemosensitivity in vitro with responses to chemotherapy. The data show that the FCA has a sensitivity of 98%, specificity of 81%, and predictive accuracies of 85% and 97% for positive and negative clinical responses, respectively.
Leone
L A
LA
Division of Biology and Medicine, Brown University, Providence, Rhode Island.
Meitner
P A
PA
Myers
T J
TJ
Grace
W R
WR
Gajewski
W H
WH
Fingert
H J
HJ
Rotman
B
B
D000970:Antineoplastic Agents / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D005260:Female; D005453:Fluorescence; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D011237:Predictive Value of Tests; D012074:Remission Induction; D012189:Retrospective Studies
D000970:Antineoplastic Agents