Acute colonic pseudo-obstruction associated with interleukin-2 therapy.
In this case report, we present a patient with metastatic gastric carcinoma who developed massive colonic dilatation during treatment with recombinant interleukin-2. The spectrum of gastrointestinal symptomatology associated with interleukin-2 therapy is broad. However, colonic pseudo-obstruction, to our knowledge, has never before been reported. We review therapy for colonic pseudo-obstruction and a proposed mechanism of interleukin-2 toxicity. We report this case to heighten awareness of the potential for the development of this complication in patients undergoing interleukin-2 immunotherapy.
Post
A B
AB
Department of Gastroenterology, Cleveland Clinic Foundation, Ohio.
Falk
G W
GW
Bukowski
R M
RM
D000208:Acute Disease; D000368:Aged; D003112:Colonic Pseudo-Obstruction / Q000139:chemically induced* / Q000473:pathology; D004108:Dilatation, Pathologic / Q000139:chemically induced; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects*; D008297:Male; D011994:Recombinant Proteins / Q000009:adverse effects
D007376:Interleukin-2; D011994:Recombinant Proteins