Tumor necrosis factor-beta specifically inhibits the activity of preoptic warm-sensitive neurons in tissue slices.
Effects of human tumor necrosis factor-beta (TNF-beta) were studied on the single neural activities of the preoptic thermosensitive and thermally insensitive neurons in tissue slices of rats. Physiological doses (0.7-40 ng/ml) of TNF-beta decreased the firing rate in most of the warm-sensitive neurons, but showed no marked tendency in the response patterns of thermally insensitive neurons. The actions of TNF-beta on warm-sensitive neurons were blocked by concurrent application of sodium salicylate. The results suggest that the intracranial TNF may produce fever through local production of prostaglandins.
Nakashima
T
T
Department of Physiology, Saga Medical School, Japan.
Kiyohara
T
T
Hori
T
T
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D002118:Calcium / Q000494:pharmacology; D066298:In Vitro Techniques; D008233:Lymphotoxin-alpha / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011301:Preoptic Area / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012980:Sodium Salicylate / Q000494:pharmacology
D008233:Lymphotoxin-alpha; D008274:Magnesium; D002118:Calcium; D012980:Sodium Salicylate