Cytoreductive surgery impedes metastasis and enhances the immune response: a preliminary report.
In an effort to determine the effect of cytoreductive surgery on the metastatic process, MAT-LyLu flank tumors were excised from Copenhagen x Fischer rats and the effects of this surgery on metastatic lung lesions were observed. Cytoreduction resulted in a decrease in lung lesions (P less than 0.05). Adjuvant cyclophosphamide (CTX) further enhanced this beneficial effect. A concurrent increase in the helper/suppressor ratios suggested that this beneficial response might be mediated by the host's immune response.
Grinis
G
G
Department of Cellular Biology, Hektoen Institute for Medical Research, University of Illinois, Chicago.
Targonski
P
P
Shaw
M
M
Rubenstein
M
M
Guinan
P D
PD
D000818:Animals; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000276:immunology* / Q000556:secondary*; D016131:Lymphocyte Subsets / Q000276:immunology; D051381:Rats
D003520:Cyclophosphamide