[Change in pulmonary artery and aorta reactions of isobaric hypoxic pulmonary hypertension in guinea-pig and milrinone's effect].
The pulmonary hypertensive model was built on guinea-pig after 1 week of isobaric hypoxia. Meanwhile, the response of pulmonary artery ring (PAR) to noradrenaline (NA) increased significantly as compared with control, but it returned to normal level after 2 week of hypoxia. The similar change was not found in aorta ring (AR). The cumulative concentration response curves of PAR, AR to NA shifted to right with dose dependent relationship after Mil pretreated either control or hypoxic groups. Hypoxia decreased the sensitivity of AR to Mil significantly but not much on PAR.
Wu
P F
PF
Department of Pathophysiology, Chinese Academy of Medical Sciences, Beijing.
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology*; D000860:Hypoxia / Q000150:complications; D008297:Male; D020105:Milrinone; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011651:Pulmonary Artery / Q000187:drug effects*; D011728:Pyridones / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D011728:Pyridones; D014665:Vasodilator Agents; D020105:Milrinone