Patterns of normal transvalvular regurgitation in mechanical valve prostheses.
The magnitude and spatial distribution of normal leakage through mechanical prosthetic valves were studied in an in vitro model of mitral regurgitation. The effective regurgitant orifice was calculated from regurgitant rate at different transvalvular pressure differences and flow velocities. This effective orifice area was 0.6 to 2 mm2 for three tilting disc prostheses (Medtronic-Hall sizes 21, 25 and 29) and 0.2 to 1.1 mm2 for three bileaflet valves (St. Jude Medical sizes 21, 25 and 33). In the single disc valves, Doppler color flow examination disclosed a prominent central regurgitant jet around the central hole for the strut, accompanied by minor leakage along the rim of the disc (central to peripheral jet area ratio 3.3 +/- 1.2). The bileaflet prostheses showed a peculiar complex pattern: in planes parallel to the two disc axes, convergent peripherally arising jets were visualized, whereas in orthogonal planes several diverging jets were seen. Mounting the disc and bileaflet valves on a water-filled tube allowed reproduction and interpretation of this pattern: for the bileaflet valve, the jets originated predominantly from valve ring protrusions that contained the axis hinge points and created a converging V pattern in planes parallel to the leaflets and a diverging V pattern in orthogonal planes. Similar patterns were observed during transesophageal echocardiography in 20 patients with a normally functioning St. Jude prosthesis. In 10 patients with a Medtronic-Hall valve, a dominant central jet was observed with one or more smaller peripheral jets. The median central to peripheral jet area ratio was 5 to 1.(ABSTRACT TRUNCATED AT 250 WORDS)
Noninvasive Cardiac Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston.
F A
FA
Flachskampf
J P
JP
O'Shea
B P
BP
Griffin
L
L
Guerrero
A E
AE
Weyman
J D
JD
Thomas
D001783:Blood Flow Velocity; D001794:Blood Pressure; D004452:Echocardiography / Q000379:methods; D015150:Echocardiography, Doppler; D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve; D008955:Models, Cardiovascular; D011474:Prosthesis Design