[Insular modifications in glycerophosphate dehydrogenase in diabetes].
In the model of non-insulin-dependent diabetes found in adult rats injected with streptozotocin during the neonatal period, the activity of the mitochondrial glycerophosphate dehydrogenase is severely reduced in pancreatic islets. This coincides with a decreased contribution of aerobic to total glycolysis in intact islets and could account for the preferential impairment of the insulin secretory response to glucose.
Malaisse
W J
WJ
Laboratoire de Médecine expérimentale, Université libre de Bruxelles.
Rasschaert
J
J
D000818:Animals; D002237:Carbohydrate Dehydrogenases / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D006019:Glycolysis; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000201:enzymology*; D008928:Mitochondria / Q000201:enzymology; D051381:Rats
D007328:Insulin; D002237:Carbohydrate Dehydrogenases; C056470:3-glycerophosphate dehydrogenase
Altération insulaire de la navette du glycerophosphate dans le diabète.