No sensory neuropathy during pyridoxine treatment in homocystinuria.
Seventeen patients with cystathionine synthase deficiency homocystinuria were examined clinically and neurophysiologically for evidence of sensory neuropathy. All had received high dose pyridoxine (vitamin B-6) for many years. Absence of neurological disturbance in all cases suggests long term treatment with pyridoxine in the dosages used in homocystinuric patients is not harmful.
Willink Biochemical Genetics Unit, Royal Manchester Children's Hospital.
C
C
Mpofu
S M
SM
Alani
C
C
Whitehouse
B
B
Fowler
J E
JE
Wraith
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006712:Homocystinuria / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009420:Nervous System / Q000187:drug effects*; D011736:Pyridoxine / Q000008:administration & dosage* / Q000627:therapeutic use; D013997:Time Factors
D011736:Pyridoxine