Hereditary protein C deficiency and portal-vein thrombosis.
Inherited defects of the natural coagulation inhibitors predispose patients to thrombosis. These disorders have similar clinical presentations with a strong family history of thrombosis, episodes of recurrent venous thromboembolism, beginning in early adulthood. We report a case of upper gastrointestinal bleeding in a patient with portal hypertension due to portal-vein thrombosis secondary to hereditary protein C deficiency, an association that has seldom been reported.
dos Santos
J N
JN
Department IV, Santa Maria University Hospital, Lisbon, Portugal.
e Silva
A M
AM
Alexandrino
P
P
Saldanha
T
T
Carrageta
M O
MO
Ferreira
E
E
de Pádua
F
F
D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D020151:Protein C Deficiency; D012008:Recurrence; D013927:Thrombosis