Study of HLA class I, class II and complement genes (C2, C4A, C4B and BF) in Japanese psoriatics and analysis of a newly-found high-risk haplotype by pulsed field gel electrophoresis.
Genetic polymorphisms of HLA antigens and HLA-linked serum complement components (C2, C4A, C4B and BF) were investigated in 79 Japanese patients suffering from psoriasis. HLA typing revealed increased frequencies of HLA-A1, A2, B39, Bw46, Cw6, Cw7 and Cw11. Among complement components, positive associations were obtained with C4A4 and C4B2 and a negative association with BFF. The major histocompatibility complex haplotype (supratype), HLA-A2-Cw11-Bw46-C2C-BFS-C4A4-C4B2-DRw8 is purported to be a new high-risk haplotype in Japanese patients with psoriasis. Analysis of patients with this supratype via pulsed field gel electrophoresis showed the existence of specific, extensive DNA deletions near HLA-DR genes, but no disease-specific patterns could be observed by means of this technique. The newly-found high-risk haplotype indicates racial and ethnic differences among psoriatic patients.
Nakagawa
H
H
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Akazaki
S
S
Asahina
A
A
Tokunaga
K
K
Matsuki
K
K
Kuwata
S
S
Ishibashi
Y
Y
Juji
T
T
D000483:Alleles; D044466:Asian People / Q000235:genetics; D003165:Complement System Proteins / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007564:Japan; D008297:Male; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology; D012306:Risk
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D003165:Complement System Proteins