Localization of the early-onset breast cancer gene.
In several susceptible families, it is clear that breast cancer is associated with a gene on band q21 of chromosome 17. On the basis of analogy, it seems probable that the rare germ-line gene is prototypical of a mutant form of a gene involved in the pathogenesis of the most common cancer in women. A major effort is now under way to sequence and clone this intriguing gene.
Department of Biomedical and Environmental Health Sciences, University of California School of Public Health, Berkeley.
M C
MC
King
D001943:Breast Neoplasms / Q000235:genetics*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D010375:Pedigree
D005819:Genetic Markers