[Creatine-kinase MM in the perinatal period].
One hundred eight newborns (gestational age 36 + 1.8 weeks and birth weight 2860 +/- 240 g) had muscle type Creatine-Kinase activity (CK-MM) assayed immediately after birth (CK-I) and serially at 6-10 h (CK-II), 20-30 h (CK-III) and 40-60 h (CK-IV) of age. Using statistical Regression analysis, CK-MM levels were correlated to four perinatal parameters: gestational age, birth weight, neonatal acidosis (pH less than 7.15), mode of delivery (vaginal/cesarean section). It was observed that CK-MM activity was dependent on gestational age and correlated to the mode of delivery at time III (600 U/l) and IV (400 U/l) comparing the mean serum values of 156 + 44 U/l observed in atraumatic delivery (p less than or equal to 0.05). Our results demonstrate markedly higher levels of CK-MM following vaginal delivery especially if complicated by forceps, vacuum and breech presentation, suggesting that birth trauma may be responsible for this phenomenon.
Abt. für Neonatologie, Kinderklinik, Kantonsspital, Aarau.
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Amato
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Nagel
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P
Hüppi
D000138:Acidosis / Q000201:enzymology; D001720:Birth Injuries / Q000201:enzymology; D001724:Birth Weight; D003402:Creatine Kinase / Q000097:blood*; D036861:Delivery, Obstetric; D005865:Gestational Age; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn / Q000097:blood*; D007527:Isoenzymes; D011446:Prospective Studies; D012044:Regression Analysis
D007527:Isoenzymes; D003402:Creatine Kinase
Die Creatin-Kinase MM in der Perinatalperiode.