Non-secretory IgA kappa myeloma with distended endoplasmic reticulum: a case report.
A case of non-secretory multiple myeloma is presented. Plasma cells showed abundant cytoplasmic colloid contained in distended rough endoplasmic reticulum. Uniform cytoplasmic positivity for IgA heavy- and kappa light-chains was demonstrated with the immunoperoxidase staining technique. It is proposed that distension of the endoplasmic reticulum by immunoglobulin-related proteins is indicative of a block in their excretion or of the presence of active synthesis of the immunoglobulins or their subunits.
Raubenheimer
E J
EJ
Department of Oral Pathology, Medical University of Southern Africa, Medunsa.
Dauth
J
J
Senekal
J C
JC
D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology* / Q000473:pathology*; D010950:Plasma Cells / Q000276:immunology / Q000648:ultrastructure
D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains