Effects of torasemide on renal haemodynamics and function in anaesthetized dogs.
1. We examined the effects of torasemide (0.3 and 1 mg/kg i.v.) on renal haemodynamics and function employing renal clearance and stop-flow techniques in anaesthetized dogs and compared these with furosemide (1 and 3 mg/kg i.v.). 2. Torasemide and furosemide did not influence renal haemodynamics, in the renal clearance study, but caused a dose-related and significant increase in urine flow and urinary excretion of sodium and potassium. Torasemide and furosemide increased fractional excretion of sodium in the distal tubules with a relatively small increase in the fractional excretion of lithium (index of sodium excretion at the proximal tubules, FELi). The diuretic profile of torasemide was of long duration, compared with that of furosemide. 3. Torasemide and furosemide inhibited sodium reabsorption at the distal portion of the tubules in the stop-flow study. 4. It is suggested from these results, that the main diuretic site of action of torasemide is the ascending limb of the loop of Henlé.
Uchida
T
T
Central Research Laboratory, Green Cross Corporation, Osaka, Japan.
Hayashi
K
K
Suzuki
Y
Y
Matsumura
Y
Y
D000758:Anesthesia; D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011188:Potassium / Q000652:urine; D012079:Renal Circulation / Q000187:drug effects* / Q000502:physiology; D012964:Sodium / Q000652:urine; D013449:Sulfonamides / Q000494:pharmacology*; D000077786:Torsemide
D004232:Diuretics; D013449:Sulfonamides; D005665:Furosemide; D012964:Sodium; D011188:Potassium; D000077786:Torsemide