[Effects and side effects of intravenous gamma globulin I: the problem of immune complex formation].
This is an original contribution to the side effects of i.v. gamma globulin in patients with immunodeficiency. 73 therapies were carried out, 9 patients suffered from partially life-threatening complications. All side effects were fully reversible and occurred during the transition from antigenaemia to antibody-excess. Immunecomplexes could be quantified and C4 decreased. In view of these results we have modified our protocol giving 5 S prior to 7 S. No further complication was seen in the following 148 therapies. Hence we can conclude, that at least some complications of the i.v. gamma globulin-therapy is due to the formation of immunecomplexes and can be prevented by the application of 5 S prior to 7 S.
Medizinischen Universitätsklinik Graz, Inselspitals Bern, Schweiz.
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GP
Tilz
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Nydegger
D000293:Adolescent; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000628:therapy*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged
D007074:Immunoglobulin G
Effekte und Nebeneffekte von intravenösen Gammaglobulinen I: Das Problem der Immunkomplexbildung.