Conditioned tolerance to the heart rate effects of smoking.
This study extended our findings that behavioral tolerance to nicotine in animals can be influenced by conditioning to cardiovascular tolerance in humans. Subjects smoked one-half a cigarette during each of five trials. In the ten-minute intersmoking interval the contexts that preceded smoking were varied. Smokers in the Changing group attended to a different five-minute segment of a Sherlock Holmes radio mystery before each trial, while those in the Repeated group listened to the same segment of the tape. Presmoking heart rates were stable across the groups from trials 1 to 5. As predicted, heart rate for subjects who smoked in the same context showed tolerance to smoking from trials 1 to 5 (84.5 to 78 bpm), while subjects who smoked in in the same context showed tolerance to 83.9 bpm). COa levels increased equally for both groups over the five trials. The results of this study suggest tolerance to smoking can be influenced by learning.
University of Pittsburgh School of Medicine, PA 15213.
L H
LH
Epstein
A R
AR
Caggiula
K A
KA
Perkins
S J
SJ
McKenzie
J A
JA
Smith
D000328:Adult; D000704:Analysis of Variance; D002248:Carbon Monoxide / Q000097:blood; D003214:Conditioning, Classical / Q000502:physiology*; D004361:Drug Tolerance; D004777:Environment; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D012907:Smoking / Q000503:physiopathology
D009538:Nicotine; D002248:Carbon Monoxide