[Effect of equilateral administration of monensin and tiamulin on the peripheral nerve function and the electrocardiogram of broilers].
The influence of the simultaneous administration of monensin and tiamulin on the motor nerve conduction velocity and the refractory periods of the N. ischiadicus was studied on 4-week old cockerels. The combined administration of the two substances resulted in significant decrease of the conduction velocities of the peripheral nerve, while the relative and absolute refractory periods were seen to increase significantly as a result of the medications. The observed alteration of the peripheral nerve function in the early phase can already attribute to the development of the serious clinical signs of the toxic interaction. The simultaneous application of monensin and tiamulin caused also changes in the electrocardiogram which was expressed in a prolongation of the RS interval and the ST segment. At the same time the heart rate was reduced.
Institut für Pharmakologie und Toxikologie, Veterinärmedizinischen Universität, Budapest.
P
P
Laczay
F
F
Simon
J
J
Lehel
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002645:Chickens / Q000502:physiology*; D004224:Diterpenes / Q000494:pharmacology; D004347:Drug Interactions; D004562:Electrocardiography / Q000187:drug effects / Q000662:veterinary*; D008297:Male; D008985:Monensin / Q000494:pharmacology*; D010525:Peripheral Nerves / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D008985:Monensin; C014224:tiamulin
Einfluss der gleichzeitigen Applikation von Monensin und Tiamulin auf die periphere Nerventätigkeit und das Elektrokardiogramm bei Broilern.