[Effect of etamsylate on hemorrhagic diathesis of children with oncologic diseases. Retrospective matched-pair analysis of 64 patients in a study of 100 patients of the Münster University Pediatric Clinic].
The hemostatic efficacy of ethamsylate studied by a matched-pair analysis was not proved to be statistically significant. The appearance of bleeding signs as well as the frequency of platelet transfusions have been examined. An important side-effect was found in patients receiving ethamsylate: severe leucocytopenia (less than 1000 leucocytes/microliters) was noticed more frequently followed by an enhanced susceptibility to infections. The incidence of septic infections was proved to be significantly increased in an extended sample of 100 patients.
Universitäts-Kinderklinik, Westfälische Wilhelms-Universität Münster.
L
L
Ritter
H
H
Schlösser
J
J
Boos
P
P
Heyen
D001780:Blood Coagulation Tests; D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004979:Ethamsylate / Q000008:administration & dosage* / Q000009:adverse effects; D006474:Hemorrhagic Disorders / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy*; D016555:Matched-Pair Analysis; D012516:Osteosarcoma / Q000097:blood / Q000188:drug therapy*; D010976:Platelet Count / Q000187:drug effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy*; D012189:Retrospective Studies
D004979:Ethamsylate
Einfluss von Etamsylat auf die Blutungsneigung von Kindern mit onkologischen Erkrankungen. Retrospektive Matched-pair-Analyse von 64 Patienten bei Untersuchung von 100 Patienten der Universitätskinderklinik Münster.