Quantitative analysis of monoclonal immunoglobulins in serum of patients with amyotrophic lateral sclerosis.
In a prospective study, we analysed the presence of monoclonal immunoglobulin (moIg) in the serum from 30 patients with amyotrophic lateral sclerosis (ALS) and 30 matched controls using a sensitive Western blot technique. The incidence of serum moIg was 60% in the ALS group and 13.3% in the control group. Most ALS sera contained 2 or 3 monoclonal components. They were IgG (72.7%) and IgM (27.3%). These results corroborate the concept of a probable association between ALS and serum moIg.
Laboratoire d'Immunologie et d'Immunopathologie, UA 1172 CNRS, Hôpital de la Milétrie, Poitiers, France.
F
F
Duarte
S
S
Binet
L
L
Lacomblez
P
P
Bouche
J L
JL
Preud'homme
V
V
Meininger
D000293:Adolescent; D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000032:analysis*; D015153:Blotting, Western; D002648:Child; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000276:immunology; D013116:Spinal Cord / Q000276:immunology / Q000502:physiology
D000911:Antibodies, Monoclonal; D007136:Immunoglobulins