Fluoxetine vs. clomipramine in depressed patients: a controlled multicentre trial.
A sample of 120 patients, all of whom met DSM-III criteria for major unipolar depressive disorder, were randomly allocated to two treatment groups. Sixty patients were treated with fluoxetine and 60 with clomipramine during a 6-week period. No significant difference was found in antidepressant efficacy, with improvement occurring on both drugs. Important differences were found in the side-effects profile of each group, their incidence being significantly lower and tending to disappear during the course of treatment in the group of patients treated with fluoxetine.
Noguera
R
R
C.A.P. Güell, Institut Catala de la Salut, Girona, Spain.
Altuna
R
R
Alvarez
E
E
Ayuso
J L
JL
Casais
L
L
Udina
C
C
D000328:Adult; D000368:Aged; D002997:Clomipramine / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D005473:Fluoxetine; D002997:Clomipramine