The nasal mucociliary clearance: relevance to nasal drug delivery.
Mucociliary clearance is an important physiological defense mechanism of the respiratory tract to protect the body against noxious inhaled materials. This process is responsible for the rapid clearance of nasally administered drugs from the nasal cavity to the nasopharynx, thereby interfering with the absorption of drugs following intranasal application. This review describes the mucociliary system and the methods used for its characterization. Examples are given of the effects of drugs and additives on its functioning. Further, possible approaches are presented for increasing the residence time of drugs in the nasal cavity, thereby improving intranasal drug delivery.
Schipper
N G
NG
Center for Bio-Pharmaceutical Sciences, Leiden University, The Netherlands.
Verhoef
J C
JC
Merkus
F W
FW
D000281:Administration, Intranasal; D000818:Animals; D006801:Humans; D009079:Mucociliary Clearance / Q000502:physiology*; D010599:Pharmacokinetics