Inhibitory effects of soybean trypsin inhibitor on induction of pancreatic neoplastic lesions in hamsters by N-nitrosobis(2-oxopropyl)amine.
The effects of simultaneous soybean trypsin inhibitor (SBTI) treatment on initiation of pancreatic carcinogenesis by N-nitrosobis(2-oxopropyl)amine (BOP) were investigated. Female Syrian golden hamsters were given five weekly s.c. injections of BOP at a dose of 10 mg/kg while being administered a diet containing 5% SBTI for 5 weeks (BOP + SBTI group). Two other groups of 30 animals each received the s.c. injections of BOP or the 5% SBTI diet for the same period, alone (BOP and SBTI groups respectively). Total numbers of pancreatic dysplastic lesions in hamsters of the BOP+SBTI group were significantly decreased as compared to the BOP group values, though the incidences of pancreatic adenocarcinomas were not significantly different. Atrophic changes were, however, more severe in the BOP group than in the BOP+SBTI group pancreatic exocrine tissue, showing that treatment with SBTI was effective for protection of acinar cells from carcinogen toxicity.
Furukawa
F
F
Division of Pathology, National Institute of Hygienic Sciences, Tokyo, Japan.
Imaida
K
K
Okamiya
H
H
Shinoda
K
K
Sato
M
M
Imazawa
T
T
Hayashi
Y
Y
Takahashi
M
M
D000230:Adenocarcinoma / Q000517:prevention & control*; D000818:Animals; D001284:Atrophy / Q000139:chemically induced; D002273:Carcinogens; D006224:Cricetinae; D004336:Drug Antagonism; D004379:Duodenal Neoplasms / Q000517:prevention & control; D005260:Female; D009602:Nitrosamines / Q000037:antagonists & inhibitors*; D010190:Pancreatic Neoplasms / Q000517:prevention & control*; D013160:Splenic Neoplasms / Q000517:prevention & control; D013274:Stomach Neoplasms / Q000517:prevention & control; D014361:Trypsin Inhibitors / Q000494:pharmacology*
D002273:Carcinogens; D009602:Nitrosamines; D014361:Trypsin Inhibitors; C013622:nitrosobis(2-oxopropyl)amine