Detection of toxoplasma-specific immunoglobulin-G: assessment of a slide agglutination test.
The performance of a slide agglutination test for detection of toxoplasma-specific IgG was assessed and compared with that of the dye test and latex agglutination test. The slide agglutination test was as sensitive as, and more specific than, latex agglutination. The predictive value of a negative slide agglutination test was less than the latex agglutination test but produced results within minutes, although quantitative results were not comparable to other assays. Slide agglutination presents a rapid alternative to the latex agglutination test as a screening assay for toxoplasmosis, although patients at risk of life-threatening infection require detailed serological examination using additional methods.
Public Health Laboratory Service, St George's Hospital, London, England, UK.
P
P
Dunford
J
J
Johnson
D000372:Agglutination Tests / Q000379:methods; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007840:Latex; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000175:diagnosis*
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D007840:Latex