Melanocyte growth factor in normal human skin.
Normal human skin is shown to contain melanocyte growth factor (MeGF). We found MeGF activity in extracts of both the epidermal portion of skin and the dermal portion. This activity was completely adsorbed onto heparin beads and eluted by 2.5 M NaCl. In addition, the activity of both extracts was completely blocked by antibodies directed against basic fibroblast growth factor (bFGF). It is suggested that melanocytes in epidermis are supported by bFGF-like MeGF in normal human skin.
Department of Dermatology, Kobe University School of Medicine, Japan.
T
T
Horikawa
K
K
Nishino
Y
Y
Mishima
D000906:Antibodies / Q000276:immunology; D003429:Cross Reactions; D016222:Fibroblast Growth Factor 2 / Q000276:immunology; D006133:Growth Substances / Q000032:analysis* / Q000276:immunology; D006801:Humans; D015603:Keratinocytes / Q000737:chemistry*; D008544:Melanocytes / Q000737:chemistry*; D008938:Mitosis; D011994:Recombinant Proteins / Q000276:immunology; D012867:Skin / Q000737:chemistry*
D000906:Antibodies; D006133:Growth Substances; D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2