[Coagulation abnormalities in stroke--disseminated intravascular coagulation as a complication of subarachnoid hemorrhage].
To determine the pathogenesis of the symptomatic vasospasm (SV) following subarachnoid hemorrhage (SAH), we compared the difference in coagulation activity between 52 aneurysmal patients with SV and 20 patients without SV. The hypercoagulable state was scored according to the Disseminated Intravascular Coagulation (DIC) scoring system. Our clinical studies showed that severe SAH following aneurysmal rupture caused the hypercoagulable state and there was a good correlation between the degree of the hypercoagulable state, the severity of SV and outcome of the aneurysmal patients. We stressed in this report that the monitoring of the blood coagulation and fibrinolytic activities is very important in severe SAH and that the hypercoagulable state after SAH plays an important role on the occurrence of SV.
Fujita
K
K
Department of Neurosurgery, Kobe University School of Medicine.
Tamaki
N
N
D000368:Aged; D001777:Blood Coagulation; D002561:Cerebrovascular Disorders / Q000097:blood*; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications; D002546:Ischemic Attack, Transient / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013345:Subarachnoid Hemorrhage / Q000097:blood / Q000150:complications*