Structure of aureobasidin A.
Aureobasidin A, a new antifungal antibiotic, was isolated from the culture medium of Aureobasidium pullulans R106. Aureobasidin A was a cyclic depsipeptide consisting of eight alpha-amino acid units and one hydroxy acid unit. The structures of the units were found by acid hydrolysis of the antibiotic to be 2(R)-hydroxy-3(R)-methylpentanoic acid, beta-hydroxy-N-methyl-L-valine, N-methyl-L-valine, L-proline, allo-L-isoleucine, N-methyl-L-phenylalanine, L-leucine, and L-phenyl-alanine. The sequence of the units was identified by NMR and FAB-MS of the products from the alkaline hydrolysis of aureobasidin A.
Ikai
K
K
Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., Shiga, Japan.
Takesako
K
K
Shiomi
K
K
Moriguchi
M
M
Umeda
Y
Y
Yamamoto
J
J
Kato
I
I
Naganawa
H
H
D000595:Amino Acid Sequence; D000935:Antifungal Agents / Q000032:analysis* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D047630:Depsipeptides; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000737:chemistry; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification
D000935:Antifungal Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C071398:aureobasidin A