[Accumulation of thiamine and its metabolites in rat liver cells and mitochondria].
Penetration of thiamine and its metabolites through the liver mitochondria and blood cells of white rats has been studied. It is shown that the catabolic forms of thiamine, thiochrome and 4-methyl-5 oxyethylthiasole penetrate through the mitochondria membranes at a larger extent than thiamine and its phosphoric esters. An increase in concentration of thiamine and its metabolites in the incubation medium from 0.1 mM to 3.2 mM leads to intensification of this process. The larger permeability of thiochrome and 4-methyl-5 oxyethylthiasole through biological membranes permits explaining the principles of catabolic thiamine forms removal from the tissues and organism.
Petrov
S A
SA
Fedorko
N L
NL
Semeriukova
I A
IA
D000818:Animals; D002478:Cells, Cultured; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats; D013831:Thiamine / Q000031:analogs & derivatives / Q000378:metabolism*
C005793:thiochrome; D013831:Thiamine
Nakopychennia tiaminu ta ĭoho metabolitiv u klitynakh i mitokhondriiakh pechinky shchuriv.