Ventricular late potentials in the assessment of mitoxantrone cardiotoxicity.
Sixteen female patients underwent signal-averaged electrocardiography and radionuclide angiography for the assessment of the resting left ventricular ejection fraction in the course of chemotherapy with mitoxantrone (MTX) for advanced breast cancer. Nine patients had received prior cardiotoxic treatments. Our findings indicate that patients treated with MTX may develop late potentials.
Istituto di Clinica Medica Generale e Terapia Medica IV, Università degli Studi, Firenze, Italia.
V
V
de Leonardis
S
S
Bartalucci
P
P
Cinelli
M
M
De Scalzi
A
A
Becucci
G
G
Lottini
B
B
Neri
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008875:Middle Aged; D008942:Mitoxantrone / Q000009:adverse effects*; D011446:Prospective Studies; D011875:Radionuclide Angiography; D013318:Stroke Volume / Q000187:drug effects*
D008942:Mitoxantrone