Synthesis and antitumor activity of 7-(N-glycosylamino)-indolo[3,2-b]quinolines.
Novel indolo[3,2-b]quinolines (1d-g), introduced at the 7-position with an N-glycosylamino group, were prepared and their antitumor activities against leukemia P388 in mice were examined. The N-Galactopyranosylamino derivative (1e) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C greater than 333%, cure 5/6) than lead compound 1a.
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Y
Y
Takeuchi
M R
MR
Chang
K
K
Hashigaki
M
M
Yamato
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006027:Glycosides / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D006027:Glycosides; D007211:Indoles; D011804:Quinolines