Correction for chemical-shift artifacts in 19F imaging of PFOB: simultaneous multislice imaging.
One of the difficulties encountered in 19F NMR imaging of fluorinated blood substitutes is that these compounds often exhibit complex multipeak spectra. These peaks result in chemical-shift artifacts along the readout direction and blurred images. In addition, each peak excites a different slice (mis-selection) when a slice selection gradient is applied during the selective rf pulse. A simultaneous multislice imaging method has been developed to solve the inherent problem of mis-selection. The essence of this method is to use the two strongest peaks of the spectrum to excite controlled different multiple slices simultaneously, with or without a slice gap. The images corresponding to the two spectral lines are then separated from in- and out-of-phase images (Dixon method). This method corrects the problem of mis-selection and either improves the SNR or increases the number of slices over spectrally selective methods which image only one peak.
Department of Radiological Sciences, University of California, Irvine 92717.
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Lee
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Nalcioglu
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Buxton
D016477:Artifacts; D001802:Blood Substitutes; D003287:Contrast Media; D005461:Fluorine; D005466:Fluorocarbons; D006801:Humans; D006842:Hydrocarbons, Brominated; D008279:Magnetic Resonance Imaging / Q000379:methods*
D001802:Blood Substitutes; D003287:Contrast Media; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D005461:Fluorine; C003072:perflubron