Glucocorticoid-receptor binding sites at the 5' flanking region of a rat cytochrome CYP2B2 gene predicted with a novel computer method.
Using an original computer method to search for potential DNA binding sites for glucocorticoid-receptor complexes (GRC) (Seledtsov, I.A., Solovjev, V.V. and Merkulova, T.I. (1991) Biochim. Biophys. Acta 1089, 367-376), the presence of two such sites in the 5' flanking region of a rat cytochrome CYP2B2 gene has been predicted. This prediction has been confirmed by gel retardation experiments.
Plisov
S Y
SY
Theoretical Department Siberian Branch of the U.S.S.R. Academy of Sciences, Novosibirsk.
Merkulova
T I
TI
Seledtsov
I A
IA
D000818:Animals; D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D002850:Chromatography, Gel; D016384:Consensus Sequence; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004247:DNA / Q000378:metabolism*; D007256:Information Systems; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000235:genetics* / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid
D011965:Receptors, Glucocorticoid; D004247:DNA; D003577:Cytochrome P-450 Enzyme System