Impact of neonatal benzpyrene imprinting on thymocytic dexamethasone binding in ascitic tumor bearing rats.
1. Rats treated with a single dose of benzpyrene when newborn and inoculated with Walker's ascitic tumor cells when 6 weeks old showed 6 and 9 days later an unequivocal increase, whereas 15 and 20 days later an unequivocal decrease, in dexamethasone binding capacity (receptor number) relative to the control, i.e. a reversion of receptor activity in the course of tumor genesis. 2. The reversion of receptor activity showed a parallelism with the increase of tumor mortality over the control. 3. The experimental observations support the conclusion that neonatal exposure to benzpyrene has a depressive effect on general resistance that is reflected (or probably caused?) among others by a decrease in the binding capacity of glucocorticoid receptors.
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
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Csaba
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Holub
D000818:Animals; D000831:Animals, Newborn; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000633:toxicity*; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D003907:Dexamethasone / Q000378:metabolism*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism
D011965:Receptors, Glucocorticoid; D001564:Benzo(a)pyrene; D003907:Dexamethasone