Lowered Cu, Zn-superoxide dismutase activity in human malignant skin tumors.
We examined Cu, Zn-superoxide dismutase (SOD) activities of fifteen malignant skin tumors (four malignant melanomas, three squamous cell carcinomas, four Bowen's diseases, two basal cell epitheliomas, one sebaceous epithelioma, and one extramammary Paget's disease) and compared them with those in adjacent normal tissues of the same patients. Though there were some individual differences, all the SOD activities in tumor tissues were significantly lower than those in adjacent normal tissues of the same subjects. The average SOD activity in tumor tissues was 12.01 +/- 2.17 unit/mg protein, while that of normal tissues was 17.62 +/- 2.85. These findings agree with previous reports from various other organ tumors.
Hamanaka
H
H
Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
Miyachi
Y
Y
Tachibana
T
T
Imamura
S
S
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000201:enzymology; D012878:Skin Neoplasms / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism*
D013482:Superoxide Dismutase