The efficacy of application of lyophilized, radiation-sterilized bone graft in orthopedic surgery.
The purpose of this study is retrospective analysis of clinical application of lyophilized (freeze-dried), radiation-sterilized allografts in various orthopedic disorders. Grafts of this type have been produced by Polish tissue banks for many years, even before the production of deep-frozen grafts was started. This type of graft is still produced because of their easy storage, transportation, and distribution. Their application is successful in selected cases. Freeze-dried, radiation-sterilized cancellous or cortical-cancellous blocks, cancellous chips, or diaphyseal cortical struts were applied in 435 patients ranging from three to 74 years old. There were five main groups of procedures: posterior or anterior spine fusion, 224 cases; joint arthrodeses, 36 cases; reconstructive operations, 83 cases; filling of bone lesions, 59 cases; and posttraumatic reconstructive operations, 33 cases. The efficacy of application of lyophilized, radiation-sterilized allografts was estimated retrospectively on the basis of physical examination data and roentgenographic assessment collected during postoperative visits. Incorporation and rebuilding of the grafts as well as a satisfactory therapeutic effect were achieved in 394 (91%) patients. Excluding the cases of congenital and hypovascular pseudoarthroses, post-osteomyelitis gap and focuses, as well as Stage 2 bone lesions, it is suggested that lyophilized, radiation-sterilized allografts can be applied on the condition that intimate contact between the donor bone and host bed is complete and sustained.
Zasacki
W
W
Department of Orthopaedics, Postgraduate Medical Education Academy, Otwock, Poland.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001174:Arthrodesis / Q000379:methods; D001847:Bone Diseases / Q000601:surgery*; D016025:Bone Transplantation / Q000009:adverse effects; D001842:Bone and Bones / Q000528:radiation effects*; D002648:Child; D002675:Child, Preschool; D005612:Freeze Drying; D006801:Humans; D008875:Middle Aged; D010019:Osteomyelitis / Q000209:etiology; D012189:Retrospective Studies; D013242:Sterilization / Q000379:methods*; D013530:Surgical Wound Infection / Q000209:etiology; D014021:Tissue Preservation