[Comparative trials of fluid gelatins on hemostasis in heart surgery in adults].
The purpose of this study was to compare, in adult cardiac surgery, the results of two gelatin substitutes (Plasmion and Haemaccel) especially for haemostasis and coagulation factors. Patients showing before operation any perturbation of blood parameters (anaemia, coagulation troubles) as well as patients suffering from serious complications or deceased in the postoperative period have been excluded. This study was realised with 54 patients randomised in two groups: group P (Plasmion); group H (Haemaccel). Anaesthesia was a diazanalgesia. Hemodilution was used in combination with autologous peroperative blood transfusion and reinfusion of residual blood from ECC after ultrafiltration. The two groups were statistically similar. In average, patients received the same gelatins quantity. The only remarkable findings were: a lesser decrease of platelets number per-ECC: a lesser fibrinogen level in postoperative period with Haemaccel.
Département d'Anesthésie-Réanimation, CHU Caen.
P
P
Charlet
C
C
Zerr
D
D
Robert
C
C
Merville
P
P
Renouf
M C
MC
Khayat
D000368:Aged; D006348:Cardiac Surgical Procedures; D005112:Extracorporeal Circulation; D005260:Female; D005780:Gelatin / Q000627:therapeutic use*; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000627:therapeutic use*; D011097:Polygeline / Q000627:therapeutic use*
D010952:Plasma Substitutes; C013648:plasmion; D005780:Gelatin; D011097:Polygeline
Essais comparatifs des gélatines fluides sur l'hémostase dans la chirurgie cardiaque de l'adulte.