Abnormal acid-base regulation in salt-sensitive normotensive man.
Metabolic acidosis has recently been observed in rat models of salt-sensitive genetic hypertension. Studies in normotensive salt-sensitive men have likewise demonstrated slightly but significantly lower arterial pH and bicarbonate levels, relating salt-sensitivity to the presence of a relative acidosis in man. The administration of alkalinizing sodium salts such as sodium bicarbonate or citrate have been shown to have no effect on or to even lower blood pressure in patients with essential hypertension. Possible factors contributing to the perturbation in acid-base status include an enhanced Na+/H(+)-antiport activity, lower intracellular pH levels and altered renal electrolyte handling as found in rat models of hypertension and in patients with essential hypertension.
Abteilung für allgemeine Innere Medizin und Nephrologie, Klinikum Steglitz der Freien Universität, Berlin.
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Sharma
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Distler
D000137:Acid-Base Imbalance; D000138:Acidosis / Q000378:metabolism; D000328:Adult; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000378:metabolism*; D051381:Rats; D012982:Sodium, Dietary / Q000009:adverse effects* / Q000378:metabolism
D001639:Bicarbonates; D012982:Sodium, Dietary