High-grade T-cell lymphoma following treatment with cyclosporin A.
A 47-year-old man with persistent severe oropharyngeal ulceration developed a high-grade T-cell lymphoma soon after commencing treatment with cyclosporin A. Using Southern blotting to identify T-cell beta-chain gene rearrangements, evidence of clonal restriction was found both in blood and lymph node DNA samples. Two BamH1 rearranged bands were demonstrated in both samples. In the blood a 16 Kb band predominated, with a weaker 28 kb band. In the lymph node sample this pattern was reversed. The findings suggest that a bi-clonal population of T-lymphocytes or clonal evolution of an existing T-cell monoclone had developed, and that cyclosporin contributed to the emergence of a high-grade T-cell lymphoma.
Brown
L A
LA
Department of Histopathology, Leicester Royal Infirmary, UK.
Wiselka
M
M
Campbell
A
A
Pringle
J H
JH
Nicholson
K
K
Lauder
I
I
D015703:Antigens, CD / Q000032:analysis; D015139:Blotting, Southern; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D005838:Genotype; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D014456:Ulcer / Q000150:complications / Q000188:drug therapy / Q000473:pathology
D015703:Antigens, CD; D016572:Cyclosporine