The growth of MAT-LyLu rat prostatic adenocarcinoma can be prevented in vivo by polyamine deprivation.
The combination of inhibitors of ornithine decarboxylase and polyamine oxidase, and of antibiotics suitable for the (partial) decontamination of the gastrointestinal tract, with a polyamine deficient diet, is responsible for the almost complete inhibition of the growth of MAT-LyLu prostatic adenocarcinoma. In the tumor-bearing animals, erythrocyte spermidine levels were reduced, but spermine concentrations were increased. As has been previously observed, the increase in erythrocyte spermine level was associated with an enhancement of malignant cell death. Adriamycin administration did neither diminish tumor growth, nor potentiate the antitumor effect of polyamine deprivation treatment. Interruption of the polyamine deprivation treatment was accompanied by a significant enhancement of tumor growth. Since polyamine deprivation causes only reversible growth inhibition, it seems not appropriate as a monotherapy.
Laboratoire de Biologie Cellulaire (CNRS), Faculté de Médecine, Rennes, France.
J P
JP
Moulinoux
V
V
Quemener
B
B
Cipolla
F
F
Guillé
R
R
Havouis
C
C
Martin
B
B
Lobel
N
N
Seiler
D000230:Adenocarcinoma / Q000737:chemistry / Q000517:prevention & control*; D000818:Animals; D004032:Diet; D004317:Doxorubicin / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D000518:Eflornithine / Q000627:therapeutic use; D008297:Male; D009355:Neomycin / Q000627:therapeutic use; D009368:Neoplasm Transplantation; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors; D011073:Polyamines / Q000032:analysis / Q000037:antagonists & inhibitors*; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000517:prevention & control*; D011700:Putrescine / Q000031:analogs & derivatives / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D000097667:Polyamine Oxidase
D004317:Doxorubicin; D000518:Eflornithine; D009355:Neomycin; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011073:Polyamines; D011700:Putrescine; D000097667:Polyamine Oxidase; C044445:MDL 72527