[Diagnostic characteristics of the CA-50 and CA 72-4 tumor markers in body fluids. Use in the diagnosis of malignant effusions].
The paper presents the results of a comparative investigation of CA-50 and CA 72-4 in the serum and effusions of the control group and a group of patients with various localizations of malignant tumors. The diagnostic applicability of CA-50 in the serum is limited by a substantial extent of falsely positive results, which is not the case with CA 72-4. Malignant cells make a more intensive release of CA 72-4 into effusions than into the blood, and the situation with CA-50 is reverse. It has been established that CA-50 in the serum and that CA 72-4 in effusions are complementary parameters. Markers in effusions have more favorable diagnostic characteristics in relation to serum. Although CA 72-4 is of a more superior diagnostic reliability, the examining of both markers is of help in the differentiation of benign peritoneal and pleural effusions from the malignant ones. The persistence of these markers in body fluids does not indicate the primary origin of malignant tumors.
Opsta bolnica, Medicinski centar u Subotici.
J
J
Lemberger
E
E
Libman
M
M
Lászlo-Klein
S
S
Skenderović
A
A
Novak
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D001202:Ascitic Fluid / Q000175:diagnosis* / Q000209:etiology; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications; D005833:Genital Neoplasms, Female / Q000150:complications; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications; D009369:Neoplasms / Q000150:complications*; D016066:Pleural Effusion, Malignant / Q000175:diagnosis*; D012680:Sensitivity and Specificity
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor
Ispitivanje dijagnostickih karakteristika tumorskih markera CA-50 i CA 72-4 u telesnim tecnostima. Primena u dijagnostici malignih izliva.