Long-term toxicity/carcinogenicity study of calcium lactate in F344 rats.
The long-term toxicity/carcinogenicity of calcium lactate, a food additive, was examined in F344 rats. Calcium lactate was given ad lib. in the drinking-water at levels of 0, 2.5 or 5% to groups of 50 male and 50 female rats for two years. No clear toxic lesion was specifically caused by long-term administration of calcium lactate. No significant dose-related increase was found in the incidences of tumours in any organ or tissue. The results indicated that calcium lactate had neither toxic nor carcinogenic activity in F344 rats.
Maekawa
A
A
Division of Pathology, Biological Safety Research Center, National Institute of Hygienic Sciences, Tokyo, Japan.
Matsushima
Y
Y
Onodera
H
H
Shibutani
M
M
Yoshida
J
J
Kodama
Y
Y
Kurokawa
Y
Y
Hayashi
Y
Y
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005503:Food Additives / Q000633:toxicity*; D007773:Lactates / Q000633:toxicity*; D019344:Lactic Acid; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors
D005503:Food Additives; D007773:Lactates; D019344:Lactic Acid