[Prenatal rubella diagnosis].
Primary rubella infections during the first trimester of pregnancy are an indication for the termination, although not all of fetuses will be infected. Concerning this situation a prenatal rubella diagnostic in 55 pregnant women was carried out to demonstrate a fetal infection. Simultaneously or separately, as methods the determination of rubella IgM antibodies in fetal blood, the demonstration of viral RNA by DNA-RNA-hybridization and the cultivation of rubella virus from amniotic fluid samples were used. In 7 of 40 women the investigation of amniotic fluids showed a positive reaction of the hybridization, in 2 cases a rubella virus could be isolated. IgM rubella antibodies were found in 5 fetuses. Because of its insufficient effectivity at present the prenatal rubella diagnostic should be applied only in special situations, e.g. in cases of a wanted child.
Institut für medizinische Mikrobiologie der Martin-Luther-Universität Halle-Wittenberg.
D
D
Sandow
K
K
Rosmus
K
K
Karnahl
R
R
Bollmann
C
C
Schmidt
F
F
Hofmann
I
I
Schwanzerova
D000653:Amniotic Fluid / Q000382:microbiology; D000914:Antibodies, Viral / Q000032:analysis; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D009693:Nucleic Acid Hybridization; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000276:immunology; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D012367:RNA, Viral / Q000032:analysis; D012409:Rubella / Q000175:diagnosis* / Q000276:immunology; D012410:Rubella Syndrome, Congenital / Q000276:immunology / Q000517:prevention & control*; D012412:Rubella virus / Q000302:isolation & purification
D000914:Antibodies, Viral; D012367:RNA, Viral; C040901:rubella antibodies
Ein Beitrag zur pränatalen Rötelndiagnostik.