Rapid localization of membrane skeletal protein 4.1 (EL1) to human chromosome 1p33----p34.2 by nonradioactive in situ hybridization.
Hereditary elliptocytosis (HE) is a heterogeneous group of red-cell disorders. One class of HE patients was shown to have a mutated erythrocyte membrane skeletal protein 4.1 gene. We have recently shown that human protein 4.1 contains multiple isoforms with novel sizes, functions, and tissue-specific expression. Here, we report the subregional localization of this gene to human chromosome 1p33----p34.2, based on the fractional length, by nonradioactive in situ hybridization.
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, The Republic of China.
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D002871:Chromosome Banding; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003598:Cytoskeletal Proteins; D004612:Elliptocytosis, Hereditary / Q000097:blood / Q000235:genetics*; D004910:Erythrocyte Membrane / Q000378:metabolism; D006801:Humans; D007621:Karyotyping; D008565:Membrane Proteins / Q000235:genetics*; D009479:Neuropeptides
D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D009479:Neuropeptides; C028841:erythrocyte membrane band 4.1 protein; C120557:erythrocyte membrane protein band 4.1-like 1