[Type IV collagen and laminin levels in the sera from patients with systemic scleroderma (PSS)].
Serum type IV collagen 7S and laminin P1 levels were measured with radioimmunoassay in 33 patients with systemic scleroderma (PSS), 6 localized scleroderma (LS), and one mixed connective tissue disease (MCTD). Serum type IV collagen 7S levels were higher in PSS (5.11 +/- 1.11 ng/ml:m +/- SD) and LS (4.68 +/- 0.46 ng/ml) than in normal controls (3.90 +/- 0.85 ng/ml) (p less than 0.001). Serum laminin P1 levels were also significantly higher in PSS (1.75 +/- 0.34 U/ml) and LS (1.38 +/- 0.20 U/ml) compared to the controls (1.19 +/- 0.16 U/ml) (p less than 0.001 and p less than 0.01, respectively). A significant correlation between these two values in PSS was found (r = 0.465, p less than 0.02). These results suggest that the measurements of these values may serve as a marker of PSS.
Department of Dermatology, Yokohama City University School of Medicine.
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Kanaizuka
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T
Sasaki
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H
Nakajima
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003094:Collagen / Q000097:blood*; D005260:Female; D006801:Humans; D007797:Laminin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012595:Scleroderma, Systemic / Q000097:blood* / Q000175:diagnosis
D015415:Biomarkers; D007797:Laminin; D003094:Collagen