Effect of psychotropic agents on a model of absence epilepsy in rats.
The effect of different groups of psychotropic agents on the spontaneous absence-like paroxysms in the ECoG of rats was studied in order to evaluate the specificity of the model for antiabsence drugs. Morphine-like analgesics increased the number of paroxysms, whereas this was depressed or the discharges were completely abolished by the following drugs: d-amphetamine, tricyclic antidepressants, centrally acting anticholinergics and L-DOPA, NMDA antagonists and memantine. Since the latter drugs have been reported to be effective in petit mal epilepsy, or the NMDA antagonists and memantine, have a potential anticonvulsant effect, the results are in favour of the usefulness of the model for antiabsence drugs.
Department of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Germany.
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Frey
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Voits
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008559:Memantine / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors; D010276:Parasympatholytics / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000928:Antidepressive Agents; D010276:Parasympatholytics; D011619:Psychotropic Drugs; D007980:Levodopa; D016202:N-Methylaspartate; D009020:Morphine; D003913:Dextroamphetamine; D008559:Memantine