Dilazep-induced vasodilation is mediated through adenosine receptors.
Administration of dilazep, an inhibitor of adenosine uptake, significantly reduced systemic arterial blood pressure and increased superior mesenteric arterial conductance without affecting the plasma adenosine levels of femoral arterial or portal venous blood. Administration of a bolus dose of 8-phenyltheophylline (8-PT), an antagonist of adenosine receptors, blocked adenosine-mediated autoregulation of the superior mesenteric artery. After the blockade of adenosine receptors by 8-PT, dilazep did not produce vasodilation. These data suggest that dilazep has a vasodilating effect in vivo that is mediated by adenosine.
Zhang
Y
Y
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Geiger
J D
JD
Légaré
D J
DJ
Lautt
W W
WW
D000241:Adenosine / Q000097:blood / Q000378:metabolism; D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D002851:Chromatography, High Pressure Liquid; D004109:Dilazep / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D006706:Homeostasis; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects*; D011983:Receptors, Purinergic / Q000378:metabolism*; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
D011983:Receptors, Purinergic; D013806:Theophylline; C028322:8-phenyltheophylline; D004109:Dilazep; D000241:Adenosine