Skeletal muscle relaxation rate after fasting or hypocaloric feeding.
The effect of malnutrition on skeletal muscle relaxation is not entirely clear; some studies indicate no change and others a slowing of the relaxation rate. We investigated whether these different results were due to type of malnutrition, muscle fiber type composition, or the index used to express relaxation rate. The effect of a 2-day fast (16% body wt loss) or 1 wk of hypocaloric feeding (22.6% wt loss) on relaxation rates of soleus and extensor digitorum longus (EDL) muscles was studied in situ with the use of anesthetized adult Wistar rats. Relaxation rates were assessed for twitch contractions using half-relaxation times and exponential phase half-times and for tetanic contractions using exponential phase half-times. The rate of relaxation was unaffected by fasting, whereas hypocaloric feeding reduced relaxation rates after twitch and tetanic contractions in both soleus and EDL muscles. We conclude that slowing of skeletal muscle relaxation rate occurs after 1 wk of hypocaloric feeding but not after 2 days of fasting. The slowing is independent of muscle fiber composition, type of contraction, or the index used to express relaxation rate.
Department of Physiology, University of Toronto, Ontario, Canada.
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D000818:Animals; D001835:Body Weight / Q000502:physiology; D004558:Electric Stimulation; D002149:Energy Intake / Q000502:physiology*; D005215:Fasting / Q000502:physiology*; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D009126:Muscle Relaxation / Q000502:physiology*; D009132:Muscles / Q000502:physiology* / Q000503:physiopathology; D009748:Nutrition Disorders / Q000503:physiopathology*; D009929:Organ Size / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains