[Clinical experience of intramediastinal injection therapy via mediastinoscope for lung cancer].
As local treatments other than surgery, radiation therapy, bronchial artery infusion and intrabronchial injection of anti-cancer drugs have generally been administered to inoperative lung cancer cases. Together with these local therapies, we experienced six cases of intramediastinal injection. Indication of this therapy has been fundamentally limited to the inoperative cases in which patient performance status has deteriorated. Histologically, three cases were squamous cell carcinoma and three cases were adenocarcinoma. Injection therapy was effective in four cases where we noted alleviation of atelectasis and obstructive pneumonia brought on by the tumor, and a tendency of the tumor and swelling lymph nodes to be reduced. No side effects nor complications were evidenced. This therapy is characterized by a wider injection area in which intrabronchial injection is incapable of reaching the upper mediastinum, the bifurcation and the upper side of the hilus. The results suggest that this therapy should be used alone or together with other local therapies and prior to operation.
Matsushima
S
S
Second Department of Surgery, Nippon Medical School.
Iedokoro
Y
Y
Kitahama
H
H
Koizumi
K
K
Hioki
M
M
Tanaka
S
S
Yamate
N
N
Shoji
T
T
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D006801:Humans; D007267:Injections; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D020707:Mediastinoscopes; D008482:Mediastinum; D008875:Middle Aged
D000970:Antineoplastic Agents