Activation of the granulocyte-monocyte colony stimulating factor gene in acute myeloid leukaemia cells is not related to gene rearrangement.
Several reports have documented that leukaemic blasts produce a number of cytokines among them the granulocyte-monocyte colony stimulating factor (GM-CSF). We analysed the structure of the gene that codes for GM-CSF in 44 acute myeloid leukaemia (AML) cases in an attempt to establish whether the autocrine production of GM-CSF was due to a structural gene alteration. No structural alteration was detected in the GM-CSF gene in any of the 44 cases studied. We, therefore, conclude that the autocrine production of GM-CSF by leukaemia blasts is not dependent on gene rearrangement.
Institute of Haematology, University of Perugia, Italy.
F
F
Falcinelli
M
M
Onorato
F
F
Falzetti
R
R
Ciurnelli
J
J
Gabert
P
P
Mannoni
M F
MF
Martelli
A
A
Tabilio
D015972:Gene Expression Regulation, Neoplastic; D015321:Gene Rearrangement; D005796:Genes; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism
D012333:RNA, Messenger; D012334:RNA, Neoplasm; D016178:Granulocyte-Macrophage Colony-Stimulating Factor