[Isolation and synthesis of espintanol, a new antiparasitic monoterpene].
The in vitro leishmanicidal and trypanocidal activities of a petroleum ether extract of Oxandra espintana have been investigated. Four aromatic monoterpenes were isolated, of which two are novel: espintanol [3a], responsible for the antiparasite activity, and O-methylespintanol [4]. Espintanol was tested in vitro on 20 strains of Trypanosoma cruzi and 12 strains of Leishmania spp. Its structure was determined by spectroscopic methods and confirmed by its preparation starting from carvacrol.
Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université Paris, France.
R
R
Hocquemiller
D
D
Cortes
G J
GJ
Arango
S H
SH
Myint
A
A
Cavé
A
A
Angelo
V
V
Muñoz
A
A
Fournet
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000302:isolation & purification; D002460:Cell Line; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D007894:Leishmania mexicana; D007896:Leishmaniasis / Q000188:drug therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D013729:Terpenes / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects
D000981:Antiprotozoal Agents; D013729:Terpenes
Isolement et synthese de l'espintanol, nouveau monoterpene antiparasitaire.