The effect of a fish oil enriched diet on oxygen toxicity and lipid peroxidation in mice.
Mice were fed a chow diet or diets enriched in fish oil, sunflower oil or beef tallow for 3 weeks. Fatty acid analysis was carried out in samples of plasma, brain and lungs from these animals and large changes were found in plasma and lungs with relatively small dietary-induced changes in brain tissue. Bleeding times were increased very significantly in the fish oil group, and slightly increased in the sunflower oil group. Endogenous lipid peroxidation (measured as thiobarbituric acid reactive substances) was unchanged in lung and brain, but lung tissue from fish oil fed mice produced more lipid peroxides in vitro during incubation at 37 degrees than those of other dietary groups. Mice fed the four different diets were exposed to hyperbaric oxygen at 618, 585 and 515 kPa and convulsive activity and lung damage was recorded. No dietary-induced alterations in susceptibility to oxygen toxicity were found.
School of Physiology & Pharmacology, University of New South Wales, Kensington, Sydney, Australia.
A
A
Burns
Y G
YG
Lin
R
R
Gibson
D
D
Jamieson
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005223:Fats / Q000494:pharmacology; D005227:Fatty Acids / Q000032:analysis / Q000097:blood; D005395:Fish Oils / Q000494:pharmacology*; D006400:Hematocrit; D006931:Hyperbaric Oxygenation; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D010100:Oxygen / Q000008:administration & dosage / Q000633:toxicity*; D010938:Plant Oils / Q000494:pharmacology; D000074242:Sunflower Oil
D004042:Dietary Fats, Unsaturated; D005223:Fats; D005227:Fatty Acids; D005395:Fish Oils; D010938:Plant Oils; D000074242:Sunflower Oil; C013698:tallow; D010100:Oxygen