Effects of soman on calcium uptake in microsomes and mitochondria from rabbit aorta.
Daily administration of soman for several days results in several alterations in the vascular neuroeffector system. To determine whether or not soman alters intracellular Ca2+ uptake, the effects of acute exposure to soman or 7-day administration of 5 micrograms kg-1 of soman on the capacity of microsomes and mitochondria from rabbit aortic vascular smooth muscle to take up 45Ca2+ were determined. Acute exposure to soman concentrations of 1-100 microM did not alter significantly (P greater than 0.05) 45Ca2+ uptake by either microsomes or mitochondria. On the other hand, 7-day soman administration markedly reduced (P less than 0.05) 45Ca2+ uptake by both microsomes and mitochondria. Thus, calcium uptake and intracellular calcium uptake-dependent responses will be affected by repeated soman administration.
College of Pharmacy, University of Oklahoma Health Sciences Center Oklahoma City 73190-5040.
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D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D001386:Azides / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D066298:In Vitro Techniques; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits; D012999:Soman / Q000494:pharmacology*
D001386:Azides; D002132:Calcium Radioisotopes; D000255:Adenosine Triphosphate; D012999:Soman; D002118:Calcium