Ameloblastic carcinoma. Report of an aggressive case and review of the literature.
Odontogenic carcinomas of the jaws are classified as malignant ameloblastoma, ameloblastic carcinoma or primary intraosseous carcinoma. Because these lesions are extremely rare, microscopic diagnosis is difficult. An aggressive case of ameloblastic carcinoma of the mandible is presented. In spite of radical surgery and radiotherapy, the patient expired eight months following initial diagnosis. - A review of the literature seems to indicate that so called simple ameloblastomas rarely can dedifferentiate and metastasize following multiple inadequate surgical procedures. Although radical surgery is not necessary, local excision should be thorough. - Ameloblastic carcinoma and primary intraosseous carcinomas may be histogenetically similar. They are highly malignant tumours which should be treated aggressively. Metastasis is common and prognosis is poor.
Dept. of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor.
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Bruce
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Jackson
D000564:Ameloblastoma / Q000473:pathology; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness