[Complement behavior in rats bearing Yoshida tumors subjected to treatment with gonadotropin and PGE2].
The haemolytic activity of the total Complement (CH50) and the fractions C3 and C4 were assayed in rats transplanted with Yoshida's tumor and then treated with hCG, LH-FSH and PGE2. A relevant increase, only concerning the values of the CH50 and C3 fraction, was observed in all animals in the early days after the transplantation, probably due to a sort of stress "by transplantation". Afterwards, hCG and PGE2 induced an increase in CH50 and C3 values, but not in the C4 fraction. Treatment with LH and FSH led to a very slight increase in the CH50 and C3. In the following days, as a consequence of the cachexia, a progressive reduction of the values of the Complement was observed in all animals. Those treated with hCG also showed a little increase of survival. The authors suggest that the increase in CH50 and C3 fraction induced by the treatment with hCG and PGE2 could be an expression of increase of the aspecific humoral immunity, as a compensatory mechanism of the cell-mediated immunological depression which occurs during neoplasias.
Istituto di Patologia Generale, Università di Catania.
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Mangano
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Nobile
D000818:Animals; D002100:Cachexia / Q000097:blood / Q000209:etiology; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D015232:Dinoprostone / Q000627:therapeutic use; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D007986:Luteinizing Hormone / Q000627:therapeutic use*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012517:Sarcoma, Yoshida / Q000097:blood / Q000276:immunology / Q000628:therapy*; D013745:Tetanus Toxoid / Q000627:therapeutic use
D006063:Chorionic Gonadotropin; D003176:Complement C3; D003181:Complement C4; D013745:Tetanus Toxoid; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003165:Complement System Proteins; D015232:Dinoprostone
Andamento del complemento nei ratti portatoridi tumore di Yoshida sottoposti a trattamento con gonadotropine e PGE2.