Control of eosinophilia.
Experiments in vitro have suggested that IL5 is a late-acting factor in eosinophil production, and that other factors such as IL3, G-CSF and GM-CSF are required for the production of committed eosinophil progenitors. Furthermore, work in vitro indicates that in addition to IL5, both IL3 and GM-CSF are capable of stimulating eosinophil differentiation. Thus, there would appear to be both considerable redundancy in cytokine actions in eosinophilia as well as a complex network of cytokine activities to induce eosinophilia. Experiments in vivo, however, suggest a less complicated control mechanism, dominated by IL5.
National Institute for Medical Research, London, UK.
C J
CJ
Sanderson
D000818:Animals; D004802:Eosinophilia / Q000209:etiology* / Q000276:immunology; D004804:Eosinophils / Q000502:physiology; D006410:Hematopoiesis; D006801:Humans; D007377:Interleukin-3 / Q000502:physiology; D015848:Interleukin-5 / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology
D007377:Interleukin-3; D015848:Interleukin-5