Vitamin and micronutrient concentrations in cyclosporine-induced renal tumor from diabetic rats.
Concentrations of vitamins, biopterin, free inositol and acid-soluble carnitine were determined in cyclosporine A induced renal adenocarcinoma and uninvaded renal tissue from streptozotocin diabetic rats. Vitamin B6, thiamin, riboflavin, nicotinate, free inositol and acid-soluble carnitine were significantly decreased in tumor than nontumor tissue. Concentrations of folic acid, B12, biotin, pantothenate and biopterin were similar in both tissues. These studies suggest that renal adenocarcinoma affects concentrations of only certain vitamins and micronutrients.
Department of Medicine, UMDNJ-New Jersey Medical School, Newark 07103.
A S
AS
Reddi
G N
GN
Jyothirmayi
B
B
DeAngelis
V
V
Kabaria
O
O
Frank
H
H
Baker
D000230:Adenocarcinoma / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001708:Biopterins / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D002331:Carnitine / Q000032:analysis; D016572:Cyclosporine / Q000633:toxicity; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D007294:Inositol / Q000032:analysis; D007668:Kidney / Q000737:chemistry*; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014815:Vitamins / Q000032:analysis*
D001786:Blood Glucose; D014815:Vitamins; D001708:Biopterins; D007294:Inositol; D016572:Cyclosporine; D002331:Carnitine