Virulence of rimantadine-resistant human influenza A (H3N2) viruses in ferrets.
The influence of rimantadine-resistance mutations on the virulence of human H3N2 viruses in ferrets was examined. The similarities in virulence of the drug-resistant mutants with single amino acid substitutions at three different locations, 27, 30, and 31, within the M2 sequence and their corresponding sensitive wild-type isolates contrasted with differences in virulence between the three pairs of viruses. These data provide further evidence that rimantadine-resistant viruses that emerge during treatment of patients with the drug are unaltered both in their growth characteristics and virulence.
Sweet
C
C
Microbial Molecular Genetics and Cell Biology Research Group, University of Birmingham, United Kingdom.
Hayden
F G
FG
Jakeman
K J
KJ
Grambas
S
S
Hay
A J
AJ
D000818:Animals; D004195:Disease Models, Animal; D004352:Drug Resistance, Microbial; D005289:Ferrets; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000187:drug effects / Q000472:pathogenicity* / Q000502:physiology; D008297:Male; D009976:Orthomyxoviridae Infections / Q000382:microbiology*; D012299:Rimantadine / Q000494:pharmacology*; D014774:Virulence; D014779:Virus Replication
D012299:Rimantadine