Uterine leiomyosarcoma with massive necrosis diagnosed during gonadotropin-releasing hormone analog therapy for presumed uterine fibroid.
Recurrence of heavy vaginal bleeding and massive necrosis of a uterine leiomyosarcoma are reported in a 41-year-old female who was being treated with GnRH-a for a presumed uterine fibroid. The pathogenic mechanisms of such an event are reviewed and discussed in light of the available literature on the subject of GnRH-a and the treatment of uterine smooth muscle neoplasms.
Department of Pathology, LaGuardia Hospital, Forest Hills, New York 11375.
I F
IF
Hitti
S S
SS
Glasberg
C
C
McKenzie
B A
BA
Meltzer
D000328:Adult; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000150:complications / Q000473:pathology*; D016729:Leuprolide / Q000009:adverse effects / Q000627:therapeutic use*; D009336:Necrosis; D014592:Uterine Hemorrhage / Q000209:etiology; D014594:Uterine Neoplasms / Q000150:complications / Q000473:pathology*; D014599:Uterus / Q000473:pathology
D016729:Leuprolide