Enantioselective determination of dimethindene in urine after oral administration of racemic dimethindene.
A sensitive high-performance liquid chromatographic determination of dimethindene and its metabolite N-demethyldimethindene in urine has been developed. The quantitative analysis was followed by determination of the enantiomeric ratio of dimethindene on an alpha 1-AGP column (EnantioPac). The urinary data for nine volunteers after oral administration of racemic dimethindene are presented. The isolation, identification and synthesis of the metabolite N-demethyldimethindene are reported.
Radler
S
S
Institute of Pharmaceutical Chemistry, University of Münster, Germany.
Blaschke
G
G
D000284:Administration, Oral; D002851:Chromatography, High Pressure Liquid; D004115:Dimethindene / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D004115:Dimethindene