A case of Sjögren's syndrome with repeatedly negative findings on lip biopsy.
We report a case of Sjögren's syndrome characterized by keratoconjunctivitis sicca, parotid swelling, reduced salivary flow, and abnormalities on nuclear scanning. Two labial gland biopsies showed complete atrophy. Biopsy of an enlarged submandibular gland revealed lymphoid follicles and glandular replacement consistent with the diagnosis of Sjögren's syndrome. This case supports the concept that a negative finding on labial biopsy does not rule out a diagnosis of Sjögren's syndrome.
Department of Medicine, University of Connecticut School of Medicine, Farmington 06030.
J
J
Katz
H
H
Yamase
A
A
Parke
D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D008046:Lip / Q000473:pathology*; D012680:Sensitivity and Specificity; D012859:Sjogren's Syndrome / Q000473:pathology*; D013363:Submandibular Gland / Q000473:pathology