Metabolic control after kidney and pancreas transplantation: whole series results and effects of segmental duct obstruction versus whole pancreas with bladder diversion technique.
From October 1976 to December 1990 181 pancreatic transplants were performed in our centre on 171 Type 1 (insulin-dependent) diabetic patients. Oral glucose tolerance test evaluated 1 year after surgery in 31 subjects showed an impaired glucose tolerance at 120 min (blood glucose 9.5 +/- 0.6 mmol/l). Similar results were obtained in seven patients 3 years after transplantation (blood glucose at 120 min 8.3 +/- 1.08 mmol/l). 24h metabolic profiles performed at the same intervals showed near normal blood glucose levels and good insulin release. Preliminary data concerning a randomized, comparative study between whole pancreas with bladder diversion and segmental pancreas transplantation, showed better metabolic control in the patients who received the whole pancreas, probably due to the greater islet mass grafted.
Istituto Scientifico San Raffaele, Milan, Italy.
R
R
Caldara
X
X
Martin
A
A
Secchi
N
N
Lefrancois
J L
JL
Touraine
G
G
Pozza
J M
JM
Dubernard
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000601:surgery; D004386:Duodenum / Q000601:surgery*; D005951:Glucose Tolerance Test; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation / Q000379:methods / Q000502:physiology*; D016035:Pancreas Transplantation / Q000379:methods / Q000502:physiology*; D010183:Pancreatic Ducts / Q000601:surgery*; D012189:Retrospective Studies; D001743:Urinary Bladder / Q000601:surgery*
D001786:Blood Glucose