Excretion of technetium 99m hexakismethoxyisobutylisonitrile in milk.
The amount of radioactivity excreted in breast milk following the administration of technetium 99m hexakismethoxyisobutylisonitrile (99mTc-MIBI) to a patient referred for cold spot myocardial scintigraphy was determined. During the first 24 h after administration, only 41.2 kBq 99mTc (0.0084% of the injected dose) was excreted in 448 ml milk with the highest concentration of 0.49 kBq/ml in the first sample. The images obtained show a high concentration of 99mTc-MIBI in the lactating breasts contrary to the very small percentage excreted in the milk. Comparison with various recommendations regarding nursing after administration of radiopharmaceuticals seems to indicate that the administration of 99mTc-MIBI does not necessitate an interruption of breast-feeding.
Rubow
S M
SM
Department of Nuclear Medicine, Tygerberg Hospital, Republic of South Africa.
Ellmann
A
A
le Roux
J
J
Klopper
J
J
D000328:Adult; D001942:Breast Feeding; D005260:Female; D006801:Humans; D008895:Milk, Human / Q000737:chemistry*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging; D009570:Nitriles / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011644:Puerperal Disorders / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi
D009570:Nitriles; D015609:Organotechnetium Compounds; D017256:Technetium Tc 99m Sestamibi