Is placental mosaicism associated with poor perinatal outcome?
In 37 pregnancies with placental mosaicism detected at first-trimester chorionic villus sampling in 2000 pregnancies, two pregnancies (5.4 per cent) ended in a spontaneous abortion at 15 weeks (46,XX 47,XX, + 16) and in a perinatal loss in a term pregnancy (46,XY/47,XY, + 10), respectively. The outcome of the other 35 pregnancies was normal. The total pregnancy loss rate before 28 weeks in the first 1000 pregnancies was previously reported to be 3.6 per cent.
Department of Human Genetics, University of Amsterdam, Academic Medical Centre, The Netherlands.
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Leschot
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Wolf
D000022:Abortion, Spontaneous / Q000209:etiology; D015193:Chorionic Villi Sampling; D005260:Female; D006801:Humans; D009030:Mosaicism; D011247:Pregnancy; D011256:Pregnancy Outcome