Chromatin phospholipid changes during rat liver development.
The chromatin extracted from rat hepatocytes of different ages has been shown to contain a phospholipid fraction representing 0.47-0.59 per cent of total chromatin in newborn animals and 0.22 per cent in 45-day-old animals. No such age-related differences are observed in the nuclei. The phospholipid composition of the nuclei at different ages shows a higher level of sphingomyelin and a lower level of phosphatidylserine in newborn than in adult animals. Chromatin phospholipids have a completely different composition from that of nuclei with respect to age, particularly in newborn rats, where there is a decrease in phosphatidylcholine and an increase in phosphatidylserine.
Istituto di Patologia Generale, Università di Perugia, Italy.
E
E
Albi
M V
MV
Magni
R
R
Lazzarini
P B
PB
Gahan
D000375:Aging; D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D005260:Female; D008099:Liver / Q000737:chemistry / Q000254:growth & development*; D008297:Male; D010743:Phospholipids / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D002843:Chromatin; D010743:Phospholipids