Intraarticular corticosteroids possibly leading to local osteonecrosis and marrow fat induced synovitis.
We describe a woman with recurrent synovitis in one or both knees treated with intraarticular corticosteroid injections and two 6-day courses of methylprednisolone tablets. She later developed osteonecrosis of her distal femora and proximal tibiae. Her course was complicated by persistent synovitis associated with a large quantity of necrotic fat in the joint fluid.
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.
D J
DJ
McCarty
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G
McCarthy
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Carrera
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D001853:Bone Marrow / Q000378:metabolism*; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D050356:Lipid Metabolism; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D010020:Osteonecrosis / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging; D011859:Radiography; D013585:Synovitis / Q000209:etiology*; D014222:Triamcinolone Acetonide / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D014222:Triamcinolone Acetonide; C005900:triamcinolone hexacetonide