Paneth-like cells in an adenoma and adenocarcinoma in the ampulla of Vater.
A case of adenocarcinoma with significant Paneth cell differentiation arising in a villoglandular polyp at the ampulla of Vater is presented. Paneth-like cells, containing distinct fuchsinophilic granules, were a prominent component of the nonglandular invasive adenocarcinoma and were also seen in the associated adenomatous polyp. Lysozyme, trichrome, and periodic acid-Schiff digest stains, and electron microscopy confirmed that the granules were lysosomal in nature. This case confirms that cells with Paneth-like features can be a significant component in invasive neoplasms and can occur at unusual sites such as the ampulla of Vater.
Department of Pathology, School of Medicine, University of California, San Francisco 94143-0506.
L D
LD
Ferrell
J H
JH
Beckstead
D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology; D002454:Cell Differentiation; D003138:Common Bile Duct Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness