Topical treatment of toxic epidermal necrolysis with Iodoplex.
Toxic epidermal necrolysis (TEN) is characterized by extensive exfoliation of the epidermis, mucosal ulcerations and fever, after a recent intake of a new drug. TEN developed in an 8-year-old girl after she ingested sulfonamides and sustained skin injuries of 90% total body surface area. In addition to her critical care management, local treatment consisted of Iodoplex cream (Biosearch Laboratories, Haifa, Israel), a long-acting antimicrobial agent from which iodine is slowly released over 48 hours. Healing was observed within 8 to 17 days after initial application. Iodoplex cream is an additional topical agent for the local treatment of TEN when porcine heterografts or allografts might not be feasible.
Kaufman
T
T
Rambam Medical Center, Haifa, Israel.
Shechter
H
H
Bar-Joseph
G
G
Hirshowitz
B
B
D000180:Acrylic Resins / Q000627:therapeutic use*; D000279:Administration, Cutaneous; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D007455:Iodine / Q000627:therapeutic use*; D009824:Ointments; D011205:Povidone / Q000627:therapeutic use*; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy* / Q000473:pathology
D000180:Acrylic Resins; D000890:Anti-Infective Agents; D009824:Ointments; D007455:Iodine; C045034:Iodoplex; D011205:Povidone