Effect of prostaglandin F2 alpha on the contractile tissues of the respiratory system of the cat in experimental airway inflammation.
The in vitro reactivity of the smooth musculature of the trachea and lungs to PGF2 alpha, was studied in control cats and cats with experimental airway inflammation induced by turpentine oil. No changes were found in the reactivity of the tracheal smooth muscle, but the reactivity of the pulmonary tissue was significantly raised compared with the controls. The results indicate that PGF2 alpha may play a role in the pathogenesis of bronchial hyperreactivity after airway inflammation.
Department of Paediatrics, Faculty of Medicine, Comenius University, Martin.
P
P
Bánovcin
P
P
Visnovský
D000818:Animals; D002415:Cats; D015237:Dinoprost / Q000502:physiology*; D005260:Female; D007249:Inflammation; D008171:Lung Diseases / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000473:pathology / Q000503:physiopathology*; D012132:Respiratory Muscles / Q000473:pathology / Q000503:physiopathology*; D014132:Trachea / Q000473:pathology / Q000503:physiopathology*
D015237:Dinoprost