Tc-99m HMPAO SPECT imaging of the central nervous system in tuberous sclerosis.
Tc-99m HMPAO was used to evaluate cerebral perfusion in a patient with tuberous sclerosis. The SPECT images demonstrated reduced HMPAO uptake in regions corresponding with MRI-confirmed locations of cortical tubers. These results indicate that the lesions are characterized by vascular perfusion deficits and support the hypothesis that cortical tubers result from developmental abnormalities of the embryonic central nervous system.
Department of Psychiatry, University of Kansas Medical Center, Kansas City.
K G
KG
Sieg
J R
JR
Harty
M
M
Simmons
D F
DF
Preston
H M
HM
Erickson
D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014402:Tuberous Sclerosis / Q000175:diagnosis / Q000000981:diagnostic imaging*
D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime