Platelet aggregation in allergic reactions.
The platelet aggregation in the presence of 4 aggregation inducers was studied in 63 allergic patients, consisting of atopic and non-atopic asthmatics and aspirin-sensitive subjects, before and after inhalation tests or in vitro incubation with allergen. Basal platelet aggregation was decreased in 43% of the atopic patients for adrenaline and also in a smaller percentage for other agonists. A decreased aggregation was also observed in 3 out of 6 nonatopic patients and in aspirin-sensitive patients. In vivo or in vitro provocation tests decreased aggregation in some additional patients. These results point out to a compromise of platelets in allergic mechanisms.
Instituto Imunologia e CHIUL-INIC, Faculdade de Medicina, Lisboa, Portugal.
A G
AG
Palma-Carlos
M L
ML
Palma-Carlos
M C
MC
Santos
J R
JR
de Sousa
D006801:Humans; D006967:Hypersensitivity / Q000097:blood*; D010974:Platelet Aggregation