A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics.
A new antibiotic, okicenone was isolated from the culture broth of Streptomyces sp. KO-3599. The antibiotic possesses cytocidal activity against mammalian tumor cells in vitro at concentrations of 0.53-11.0 micrograms/ml whereas the antibiotic showed no antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1,000 micrograms/ml.
Kitasato Institute, Tokyo, Japan.
K
K
Komiyama
S
S
Funayama
Y
Y
Anraku
M
M
Ishibashi
Y
Y
Takahashi
T
T
Kawakami
S
S
Omura
D000818:Animals; D000873:Anthracenes / Q000302:isolation & purification / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000627:therapeutic use; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000873:Anthracenes; D000903:Antibiotics, Antineoplastic; C071011:okicenone