Multiple myeloma and chronic myelomonocytic leukaemia developing in a patient with autoimmune disease.
A 64-year-old lady with a personal and family history of autoimmune disease developed chronic myelomonocytic leukaemia and multiple myeloma simultaneously. Her sister died of acute myelomonocytic leukaemia, but showed no evidence of autoimmune disease. It is possible that chronic immunological stimulation, perhaps by an autoantigen, may predispose toward malignant transformation in both plasma cell and monocyte series. However, the present observations raise the alternative possibility of a primary disorder of monocytes that predisposes toward both autoimmune disease and a clonal disorder of plasma cells.
Department of Haematology, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK.
H M
HM
Habashi
R A
RA
Sharp
M J
MJ
Pippard
D001327:Autoimmune Diseases / Q000150:complications*; D005260:Female; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000276:immunology*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology*; D009378:Neoplasms, Multiple Primary / Q000276:immunology*