Naftidrofuryl protects the rat against chronic gastric ulceration.
Intraperitoneal reserpine (5 mg/kg every day for 5 days) produced solitary chronic ulceration of the rat stomach after 2 weeks. Gavage with 1 mL/day of 1% naftidrofuryl oxalate for 2 weeks protected 30% of rats against ulceration and this protection extended to 70% of cases with a 2% solution. Similar gavage with a 5% solution protected all rats against ulceration without significantly influencing the basal H+ output (14.8 +/- 0.6 versus 15.4 +/- 0.5 mumol, mean +/- SEM, n = 10); that is, cytoprotection was achieved.
University Department of Surgery, Royal Infirmary, Glasgow, U.K.
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Salim
D000818:Animals; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D007511:Ischemia / Q000150:complications; D008297:Male; D009257:Nafronyl / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D013270:Stomach / Q000098:blood supply; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D009257:Nafronyl; D012110:Reserpine