Topical treatment of toxic epidermal necrolysis with Iodoplex.
Toxic epidermal necrolysis (TEN) is characterized by extensive exfoliation of the epidermis, mucosal ulcerations and fever, after a recent intake of a new drug. TEN developed in an 8-year-old girl after she ingested sulfonamides and sustained skin injuries of 90% total body surface area. In addition to her critical care management, local treatment consisted of Iodoplex cream (Biosearch Laboratories, Haifa, Israel), a long-acting antimicrobial agent from which iodine is slowly released over 48 hours. Healing was observed within 8 to 17 days after initial application. Iodoplex cream is an additional topical agent for the local treatment of TEN when porcine heterografts or allografts might not be feasible.
Rambam Medical Center, Haifa, Israel.
T
T
Kaufman
H
H
Shechter
G
G
Bar-Joseph
B
B
Hirshowitz
D000180:Acrylic Resins / Q000627:therapeutic use*; D000279:Administration, Cutaneous; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D007455:Iodine / Q000627:therapeutic use*; D009824:Ointments; D011205:Povidone / Q000627:therapeutic use*; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy* / Q000473:pathology
D000180:Acrylic Resins; D000890:Anti-Infective Agents; D009824:Ointments; D007455:Iodine; C045034:Iodoplex; D011205:Povidone