Secretion of a potential virulence factor, a fungal ribonucleotoxin, during human aspergillosis infections.
We show by cloning and nucleotide sequence analysis that the 18kDa antigen found in the urine of patients suffering from aspergillosis is related to the fungal protein toxins restrictocin and mitogillin. These are inhibitors of translation which act by catalytic inactivation of eukaryotic ribosomes; they may be implicated in the pathogenesis of the disease.
Lamy
B
B
Unité de Génie Microbiologique, Institut Pasteur, Paris, France.
Moutaouakil
M
M
Latge
J P
JP
Davies
J
J
D000485:Allergens; D000595:Amino Acid Sequence; D000946:Antigens, Fungal / Q000096:biosynthesis; D052179:Antigens, Plant; D001228:Aspergillosis / Q000209:etiology / Q000652:urine*; D001232:Aspergillus fumigatus / Q000378:metabolism / Q000472:pathogenicity*; D001483:Base Sequence; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000652:urine*; D006801:Humans; D016253:Microscopy, Immunoelectron; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009183:Mycotoxins / Q000737:chemistry / Q000235:genetics / Q000652:urine*; D012337:RNA, Ribosomal, 18S / Q000378:metabolism; D012260:Ribonucleases / Q000737:chemistry / Q000235:genetics; D012270:Ribosomes / Q000378:metabolism; D016415:Sequence Alignment; D014777:Virus Diseases / Q000150:complications
C081947:ASPF1 protein, Aspergillus fumigatus; D000485:Allergens; D000946:Antigens, Fungal; D052179:Antigens, Plant; D005656:Fungal Proteins; D009183:Mycotoxins; D012337:RNA, Ribosomal, 18S; C036196:MITF protein, Aspergillus restrictus; D012260:Ribonucleases