Interleukin-2 enhances the release of endothelin-1 from the rat mesenteric artery.
We measured the ET-1 concentration in plasma and in the perfusate of the mesenteric arteries of rats treated with a therapeutic dose of IL-2 for 7 days (100000 U/Kg, iv.). The plasma ET-1 concentration in rats given IL-2 was 14.2 +/- 3.2 pg/ml which was significantly greater than that in the controls (2.5 +/- 0.4 pg/ml, P less than 0.05). The mesenteric arteries also released a significantly greater amount of ET-1 (29.5 +/- 1.6 pg/h) than that in controls (16.8 +/- 2.3 pg/h, P less than 0.01). The arterial blood pressure was significantly lower after IL-2 treatment than the pre-dosing level (P less than 0.05). It is concluded that IL-2 induces ET-1 release from the vascular wall, possibly as a result of reversible endothelial dysfunction caused by IL-2.
Miyamori
I
I
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Takeda
Y
Y
Yoneda
T
T
Iki
K
K
Takeda
R
R
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D016232:Endothelins / Q000097:blood / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D007124:Immunoenzyme Techniques; D007376:Interleukin-2 / Q000494:pharmacology*; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D016232:Endothelins; D007376:Interleukin-2