Anti-neutrophil cytoplasmic antibodies (ANCA): a seromarker for Wegener's granulomatosis.
Wegener's granulomatosis can be a difficult diagnosis to establish. It is not uncommon to require repeated biopsies over many months for histologic confirmation. A recently developed seromarker--anti-neutrophil cytoplasm antibody--ANCA (synonymous with anticytoplasmic autoantibody--ACPA) adds a new and valuable tool for diagnosis. The literature shows this to be a highly specific and sensitive test for Wegener's granulomatosis.
Turner
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The Medical Centre, Grand Falls, Newfoundland, Canada.
D001323:Autoantibodies / Q000032:analysis*; D003593:Cytoplasm / Q000276:immunology; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D009668:Nose Diseases / Q000276:immunology / Q000473:pathology*; D010254:Paranasal Sinus Diseases / Q000276:immunology / Q000473:pathology*; D012698:Serologic Tests
D001323:Autoantibodies