Polymorphism at codon 213 within the p53 gene.
This report describes a rare polymorphism at codon 213 (silent alteration of CGA to CGG) within the coding region of the p53 gene. The rare polymorphic allele was present in six cases out of 189 lung and breast cancer DNAs analyzed (3.2%) and resulted in the loss of a TaqI site. This allele could be mistaken for a mutation when screening methods of mutation analysis are used without comparison with normal tissue DNA.
Navy Medical Oncology Branch, National Cancer Institute, Bethesda, Maryland 20889-5105.
D
D
Carbone
I
I
Chiba
T
T
Mitsudomi
D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics; D003062:Codon / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D016158:Genes, p53; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D011110:Polymorphism, Genetic
D003062:Codon; D004273:DNA, Neoplasm