[The observation of experimental respiratory distress syndrome and effects of anisodamine].
The respiratory distress syndrome (RDS) model induced by oleic acid injection in dogs and treated by anisodamine were observed. The clinical picture, blood gas parameters, Pap, Pwp, blood cells count, hemocoagulogram, CH50, and surface tension of BALF were studied in order to determine the pathophysiological mechanism and effects of anisodamine. According to the studies in our laboratory, it was suggested that the complement activation and neutrophil aggregation induced by C5a and mediators released by it and other way are likely to be the initiation factors. The lung injuries complicated diffuse intravascular coagulation with fibrinolysis occurred for whole 72 hours period. The anisodamine seems to exert certain therapeutic effects on RDS through preventing the complement activation and enable the lysosomal elimination decrease and stimulate the II-type epithelia to be repaired.
Gao
X J
XJ
Department of Respiratory Disease, Second Affiliated Hospital, Third Millitory College, Chongqing.
D000818:Animals; D003167:Complement Activation / Q000187:drug effects; D004285:Dogs; D008168:Lung / Q000473:pathology; D009829:Oleic Acids; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*
D009829:Oleic Acids; D012991:Solanaceous Alkaloids; C003922:anisodamine