Ketanserin in the treatment of hypertension: a multicentre dose-finding study in China.
The effect of ketanserin at 5 mg, 10 mg and 20 mg twice daily for 3 months was studied in Chinese patients with hypertension. Both 10 mg and 20 mg doses twice daily effectively reduced systolic and diastolic pressures, while 5 mg twice daily was not effective. The 20 mg regimen was more effective than 10 mg in reducing diastolic, but not systolic pressures. Blood pressure reduction was progressive up to 1 month of treatment but not thereafter. Neither first-dose hypotension nor postural hypotension were seen. There were no effects on body weight or heart rate. A nominally significant 6 msec increase in QTc was seen with 10 mg, but not with 5 or 20 mg twice daily; this could be a chance finding. The side-effect burden was light, and decreased with time.
Liu
G S
GS
Department of Cardiology, Chinese PLA General Hospital, Beijing.
Huang
D X
DX
Yang
X S
XS
Wang
S R
SR
Tang
X L
XL
Xing
J L
JL
Peng
S Y
SY
Tong
Y Z
YZ
D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007650:Ketanserin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male
D007650:Ketanserin