[Modification and visualization of the allergic reaction in isolated and innervated organs].
The model-systems, as are isolated innervated organs (IIO) taken out from the sensibilized animals, could improve the screening of immunomodulators. The stimulation of extrinsic motor nerves of IIO contemporary with antigen-antibody reaction (AAR) produced two types of responses. The first type was the increase of tonus and the induced contractions. The second type of reaction was the decrease of the contractions. The first type of response was recorded when the motor nerve was cholinergic and the second type of reaction was recorded when the motor nerve was adrenergic-purinergic (vas deferens). Guinea-pigs and rabbits were the most convenient experimental animals. The preparation of mice and rats for the immunological experiments should be improved, the more so from mice and rats, since useful model-systems could be obtained. Human serum and white of eggs were the most convenient antigens. The immunomodulators thymopentin and muramyl dipeptide injected before or after AAR did not change the tonus and induced contractions in comparison with control ones.
Zuković
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D000818:Animals; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000276:immunology*; D007114:Immunization; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009046:Motor Neurons / Q000276:immunology* / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D009132:Muscles / Q000276:immunology*; D051381:Rats
D000941:Antigens
Modifikacija i vizualizacija alergijske reakcije na izolovanim inerviranim organima (IIO).