Changes in parafollicular cells of rats neonatally treated with estradiol.
The parafollicular cells of male and female rats neonatally (3rd day) treated with a single dose (1 mg) of estradiol dipropionate, and sacrificed in peripubertal (38th day) or adult (80th day) period of life, were investigated. These studies included examinations of silver-stained properties of parafollicular cells, morphometric analyses of both the cells and nuclear area and ultrastructural characteristics. Estradiol treatment led to a significant increase of the cellular and nuclear area (micron 2) in both females and males. Different from intact animals remarkable degranulation and hyperplasia of parafollicular cells were evident in estradiol-treated rats. It may be concluded that this sexual hormone applied in neonatal period has an effect on parafollicular cells expressed up to adult period of life.
Sekulić
M
M
Institute for Biological Research, Division of Cytology and Embryology, Beograd, Yugoslavia.
Lovren
M
M
D000818:Animals; D000831:Animals, Newborn; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects / Q000648:ultrastructure*
D004958:Estradiol