Effect of gentamicin on vestibular ganglion.
The morphological changes of the vestibular ganglion induced by gentamicin (GM) were investigated using light, scanning and transmission electron microscopy. The guinea pigs were injected 4 mg of GM into the middle ear for 5 days. The vestibular ganglion was observed up to 4 weeks after the treatment. Three days after the treatment the degenerative change was first noted in the vestibular ganglion. The degenerative process started from the destruction of mitochondrial cristae and vacuolization of the cytoplasm of the Schwann cell. The cytoplasmic organelles in the ganglion cell gradually deteriorated with swelling of the endoplasmic cisterns as well as Golgi apparatus. At the later stage, the myelin sheath around the ganglion cell disappeared and the number of the cells reduced. These changes of the ganglion cell may be due to the direct action of GM.
Department of Otolaryngology, Hiroshima University School of Medicine, Japan.
Y
Y
Harada
K
K
Sera
T
T
Ohya
N
N
Tagashira
M
M
Suzuki
M
M
Takumida
D000818:Animals; D003593:Cytoplasm / Q000187:drug effects / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D005724:Ganglia / Q000187:drug effects* / Q000473:pathology; D005839:Gentamicins / Q000633:toxicity*; D006168:Guinea Pigs; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009186:Myelin Sheath / Q000187:drug effects / Q000648:ultrastructure; D012583:Schwann Cells / Q000187:drug effects / Q000648:ultrastructure; D014722:Vestibule, Labyrinth / Q000187:drug effects* / Q000473:pathology
D005839:Gentamicins