[Bacteriostatic activity of blood in patients with pulmonary tuberculosis during polychemotherapy].
Polychemotherapy comprising 4-6 antituberculosis drugs and prescribed either only daily, daily or given on an intermittent basis (every other day) or only on an intermittent basis was given for 4-8 months to 102 patients with destructive pulmonary tuberculosis (in those newly diagnosed, treated earlier and with a process recurrence). Four and, less frequently, three drugs were used per day. Bacteriostatic blood activity (BBA) was high in 90.2% of the patients, at the maximal concentrations, bacteriostasis was seen at 32-256-fold blood dilutions; in 76.4% of the patients BBA persisted at a high or moderate level during 24 hours (blood dilutions were within 1:256-1:8). The maximal and total BBA level was significantly higher in polychemotherapy than in a combination of 3 drugs. In polychemotherapy bacilli excretion was discontinued in 90% and caverns healed in 74.5% of the patients, while in the regimens comprising 3 drugs in the same contingent of patients, similar events occurred in 77% and 60% of the cases, respectively.
Bialik
I V
IV
Klimenko
M T
MT
Ginzburg
T S
TS
D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage*; D001770:Blood Bactericidal Activity / Q000187:drug effects / Q000276:immunology*; D004352:Drug Resistance, Microbial / Q000276:immunology; D004359:Drug Therapy, Combination; D006801:Humans; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology
D000995:Antitubercular Agents
Bakteriostaticheskaia aktivnost' krovi bol'nykh tuberkulezom legkikh pri polikhimioterapii.