The properdin structural locus (Pfc) lies close to the locus for tissue inhibitor of metallothionine proteases (Timp) on the mouse X chromosome.
We have confirmed the assignment of the structural locus of the complement factor properdin (Pfc) to the mouse X chromosome and mapped it between monoamine oxidase-A (Mao-a) and hypoxanthine phosphoribosyltransferase (Hprt) using a Mus spretus x Mus musculus interspecific backcross of 108 animals. The structural locus for murine tissue inhibitor of metallothionine proteases (Timp) could not be separated from properdin in a panel of 18 recombinant animals. By minimizing the number of double recombinants the following gene order was obtained: Otc-Mao-a-(Pfc, Timp)-Hprt-Cf-9. The implications for comparative mapping of human and mouse X chromosomes are discussed.
MRC Radiobiology Unit, Didcot, Oxon, United Kingdom.
S H
SH
Laval
Z Y
ZY
Chen
Y
Y
Boyd
D000818:Animals; D015139:Blotting, Southern; D002503:Centromere / Q000648:ultrastructure; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006023:Glycoproteins / Q000235:genetics*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D011414:Properdin / Q000235:genetics*; D011995:Recombination, Genetic; D019714:Tissue Inhibitor of Metalloproteinases; D014960:X Chromosome
D006023:Glycoproteins; D019714:Tissue Inhibitor of Metalloproteinases; D011414:Properdin; D004247:DNA