Total intravenous anaesthesia with propofol or etomidate.
In combination with fentanyl, propofol was compared with etomidate for total intravenous anaesthesia in 21 women (ASA Grades I-II) admitted for elective hysterectomy. They received either propofol (bolus 1.5 mg kg-1, infusion 9 mg kg-1 h-1 for 10 min thereafter 6 mg kg-1 h-1) or etomidate (bolus 0.10 mg kg-1, infusion 3 mg kg-1 h-1 reduced to 0.6 mg kg-1 h-1). Fentanyl 10 micrograms kg-1 was given for induction followed by an infusion of 30 micrograms kg-1 h-1 for 10 min reduced to 6 micrograms kg-1 h-1 for the first hour and successively reduced over time. Induction was smooth and maintenance easy to manage in both groups. There was no difference in time from end of infusion until extubation, but the time until the patients could report their date of birth was significantly shorter in the propofol group. Nausea and vomiting were more pronounced in the etomidate group, and mental side-effects were only seen after etomidate. After 3 months, more patients in the etomidate group complained of reduced power of concentration. We conclude that total intravenous anaesthesia with either propofol or etomidate is equally easy to manage, but in the recovery situation propofol was advantageous in time and quality.
Department of Anaesthetics, Central Hospital of Hillerød, Denmark.
K
K
Fruergaard
M
M
Jenstrup
J
J
Schierbeck
F
F
Wiberg-Jørgensen
D000328:Adult; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous / Q000379:methods; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D003243:Consciousness / Q000187:drug effects; D005045:Etomidate / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007044:Hysterectomy; D008606:Mental Processes / Q000187:drug effects; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D013997:Time Factors; D014839:Vomiting / Q000209:etiology
D002245:Carbon Dioxide; D005283:Fentanyl; D015742:Propofol; D005045:Etomidate