Secretion and elimination of insulin by the in vitro perfused pancreas and liver of rats with thioacetamide-induced liver cirrhosis.
Pancreatic secretion and hepatic removal of insulin have been measured in thioacetamide (TAA)-induced compensated rat liver cirrhosis in perfusion experiments. Peripheral plasma concentrations of glucose and insulin were slightly decreased in TAA-treated rats. Pancreatic secretion and hepatic removal of insulin remained unchanged by the TAA-treatment. Thus, even in morphologically and biochemically proven experimental liver cirrhosis, insulin secretion and removal may not be disturbed.
Institut für Biochemie, Martin-Luther Universität Halle-Wittenberg, Germany.
H J
HJ
Brömme
T
T
Zimmermann
W
W
Blech
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism*; D051381:Rats; D013853:Thioacetamide
D007328:Insulin; D013853:Thioacetamide