Complement in inflammation: induction of nephritides and progress to chronicity.
The C5b-9 complex has a dual role as a factor involved in the initiation of nephritides and in the progress to chronicity and sclerosis. The unique pathophysiology of the membrane attack complex, distinct from other mediators, is its independence from specific receptors. It inserted in any membrane lipid bilayer tested so far.
Rother
K
K
Institute of Immunology, University of Heidelberg, FRG.
Hänsch
G M
GM
Rauterberg
E W
EW
D000818:Animals; D002908:Chronic Disease; D015938:Complement Membrane Attack Complex / Q000502:physiology*; D005246:Feedback; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology; D009393:Nephritis / Q000209:etiology*
D015938:Complement Membrane Attack Complex