Enhanced exercise-induced rise of aldosterone and vasopressin preceding mountain sickness.
A possible contribution of exercise to the fluid retention associated with acute mountain sickness (AMS) was investigated in 17 mountaineers who underwent an exercise test for 30 min on a bicycle ergometer with a constant work load of 148 +/- 9 (SE) W at low altitude (LA) and with 103 +/- 6 W 4-7 h after arrival at 4,559 m or high altitude (HA). Mean heart rates during exercise at both altitudes and during active ascent to HA were similar. Exercise-induced changes at LA did not differ significantly between the eight subjects who stayed well and the nine subjects who developed AMS during a 3-day sojourn at 4,559 m. At HA, O2 saturation before (71 +/- 2 vs. 83 +/- 2%, P less than 0.01) and during exercise (67 +/- 2 vs. 72 +/- 1%, P less than 0.025) was lower and exercise-induced increase of plasma aldosterone (617 +/- 116 vs. 233 +/- 42 pmol/l, P less than 0.025) and plasma antidiuretic hormone (23.8 +/- 14.4 vs. 3.4 +/- 1.8 pmol/l, P less than 0.05) was greater in the AMS group, whereas exercise-induced rise of plasma atrial natriuretic factor and changes of hematocrit, potassium, and osmolality in plasma were similar in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Bärtsch
P
P
Department of Medicine, Medizinische Poliklinik Inselspital, Bern, Switzerland.
Maggiorini
M
M
Schobersberger
W
W
Shaw
S
S
Rascher
W
W
Girard
J
J
Weidmann
P
P
Oelz
O
O
D000064:Acclimatization / Q000502:physiology; D000082:Acetaminophen / Q000627:therapeutic use; D000328:Adult; D000375:Aging / Q000502:physiology; D000450:Aldosterone / Q000097:blood*; D000532:Altitude Sickness / Q000097:blood* / Q000188:drug therapy / Q000652:urine; D001798:Blood Proteins / Q000378:metabolism; D015444:Exercise; D005080:Exercise Test; D006339:Heart Rate / Q000502:physiology; D006400:Hematocrit; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009051:Mountaineering; D010101:Oxygen Consumption; D011654:Pulmonary Edema / Q000503:physiopathology; D014563:Urodynamics / Q000502:physiology; D014667:Vasopressins / Q000097:blood*; D014882:Water-Electrolyte Balance / Q000502:physiology
D001798:Blood Proteins; D006728:Hormones; D014667:Vasopressins; D000082:Acetaminophen; D000450:Aldosterone