Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid.
Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, PA 19111.
P J
PJ
Ciaccio
K D
KD
Tew
F P
FP
LaCreta
D000818:Animals; D002699:Chlorambucil / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004976:Ethacrynic Acid / Q000494:pharmacology*; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D008658:Inactivation, Metabolic; D007525:Isoelectric Focusing; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D051379:Mice; D010053:Ovary / Q000201:enzymology
D002699:Chlorambucil; D005982:Glutathione Transferase; D005978:Glutathione; D004976:Ethacrynic Acid