Interaction between morphine and noradrenaline on isolated heart muscle.
1. We evaluated the interaction between morphine and noradrenaline on the right atria. 2. Noradrenaline significantly increased atrial contraction rate, with an effective concentration 16 (EC16) of 85 +/- 0.8 x 10(-9) M. 3. The EC16 of noradrenaline significantly decreased in the presence of morphine. 4. These results demonstrate that morphine increases the potency of noradrenaline on the isolated right atria.
Department of Physiology and Pharmacology, Murcia University School of Medicine, Spain.
M I
MI
Valcarcel
F
F
Ruiz
M L
ML
Laorden
D000818:Animals; D004357:Drug Synergism; D005260:Female; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D009638:Norepinephrine / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains
D009020:Morphine; D009638:Norepinephrine