HLA antigens influence resistance to lung carcinoma.
The concept of genetic factors playing a role in the pathogenesis of lung cancer has gained increased attention. The present study was undertaken to reexamine the question of HLA antigen association with carcinoma of the lung. In a study of 90 patients, a significant association occurred between HLA-DR7 and resistance to lung cancer, after accounting for smoking status and sex. HLA class I antigens were also implicated. These results suggest that major histocompatibility complex loci affect carcinoma of the lung.
Department of Pharmacology, Pennsylvania State University, College of Medicine, Hershey 17033.
P J
PJ
Romano
M
M
Bartholomew
P J
PJ
Smith
F
F
Kloszewski
J
J
Stryker
J
J
Houck
E S
ES
Vesell
D002277:Carcinoma / Q000209:etiology / Q000276:immunology*; D004198:Disease Susceptibility; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007113:Immunity, Innate; D008175:Lung Neoplasms / Q000209:etiology / Q000276:immunology*; D008297:Male; D012737:Sex Factors; D012907:Smoking
D006680:HLA Antigens