Effects of depleting central and peripheral adrenaline stores on blood pressure in stroke-prone spontaneously hypertensive rats.
The potential role of adrenaline, both circulating and in the central nervous system, in the maintenance of high blood pressure was examined in stroke-prone spontaneously hypertensive rats (SHRSP). alpha-Monofluoromethyldopa, a long-lasting inhibitor of dopa decarboxylase, was used to induce rapid depletion of central and peripheral catecholamine stores. Subsequent inhibition of phenylethanolamine-N-methyltransferase (PNMT) allowed the gradual restoration of dopamine and noradrenaline but not adrenaline, resulting in a greater relative depletion of adrenaline. Adrenaline was almost totally depleted in the circulation and peripheral tissues. The resting level of blood pressure, however, was unaffected, excepting after administration of a vasopressin (AVP) antagonist. Moreover, there was no reduction in the magnitude of acute pressor responses to electrical stimulation of the rostral ventrolateral medulla oblongata (C1 area), despite extensive loss of adrenaline from the brainstem and spinal cord. The results suggest that adrenaline contributes to the resting level of blood pressure but that its loss can be offset by the pressor activity of AVP. Thus neither central nor peripheral adrenaline stores appear to be essential for the maintenance of hypertension or for centrally-evoked vasoconstriction in adult SHRSP.
CSIRO Division of Human Nutrition, Adelaide, SA, Australia.
P F
PF
Rogers
G A
GA
Head
Y K
YK
Lungershausen
P R
PR
Howe
D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D018492:Dopamine Antagonists; D004558:Electric Stimulation; D004837:Epinephrine / Q000037:antagonists & inhibitors*; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology; D008750:Methyldopa / Q000031:analogs & derivatives* / Q000494:pharmacology; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D010625:Phenylethanolamine N-Methyltransferase / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR
D018492:Dopamine Antagonists; D008750:Methyldopa; C019494:alpha-monofluoromethyldopa; D010625:Phenylethanolamine N-Methyltransferase; D009638:Norepinephrine; D004837:Epinephrine