Detection of a carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in cigarette smoke condensate.
A carcinogenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), was measured in condensate of cigarette mainstream smoke by HPLC. PhIP was detected in all brands of filter-tipped cigarettes analyzed. The mean level of PhIP in the cigarette mainstream smoke was 16.4 ng/cig.
Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo, Japan.
S
S
Manabe
K
K
Tohyama
O
O
Wada
T
T
Aramaki
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D007093:Imidazoles / Q000032:analysis* / Q000302:isolation & purification; D009153:Mutagens / Q000032:analysis* / Q000302:isolation & purification; D012906:Smoke / Q000032:analysis*
D007093:Imidazoles; D009153:Mutagens; D012906:Smoke; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine