[Experimental studies of retinal ultrastructure after administration of highly fluorinated alkane into the vitreous body].
In experimental investigations the hydrogen-fluoroalkane was introduced into the rabbit vitreous and subsequently the retina was examined in the electron microscope. The observations were carried out in 1, 4 and 8 weeks after introduction of the compound. It was demonstrated that the fluoroalkane penetrated into the internal retinal layers. These layers showed the presence of macrophages, the cytoplasm of which indicated the absorption of the compound. The structure of the retina was preserved till the end of the observation. The compound did not exert any toxic action.
Kliniki Okulistycznej AM w Lublinie.
J
J
Toczołowski
M
M
Gerkowicz
D000473:Alkanes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D004058:Diffusion; D006845:Hydrocarbons, Fluorinated / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007267:Injections / Q000379:methods; D008854:Microscopy, Electron; D008954:Models, Biological; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000648:ultrastructure; D013997:Time Factors; D014822:Vitreous Body / Q000187:drug effects*
D000473:Alkanes; D006845:Hydrocarbons, Fluorinated
Badania doświadczalne nad ultrastruktura siatkówki po podaniu wysoko fluorowanego alkanu do ciała szklistego.