Outcome of pregnancy following renal transplantation.
Successful renal transplantation improves fertility with 1 in 50 women of childbearing age becoming pregnant. Pregnancy following renal transplantation is associated with increased maternal and fetal complications. In Belfast 118 women of childbearing age (15-45 yrs) have received a renal allograft and of these 14 (12%) have become pregnant. Twenty-seven pregnancies have resulted in 23 live births (including one set of identical twins), 1 still birth and 4 first trimester abortions. The most frequent complications were hypertension and prematurity. In this group of patients, whose sole immunosuppressive therapy was azathioprine and prednisolone, pregnancy post transplantation was associated with frequent successful outcome and a low incidence of maternal and fetal complications.
Regional Nephrology Unit, Belfast City Hospital.
J H
JH
Brown
A P
AP
Maxwell
M G
MG
McGeown
D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000009:adverse effects; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009660:Northern Ireland / Q000453:epidemiology; D011239:Prednisolone / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D011256:Pregnancy Outcome
D011239:Prednisolone; D001379:Azathioprine