Distribution of parvalbumin immunoreactivity in the human brain.
The cellular distribution of parvalbumin-like immunoreactivity (PA-LI) in the human brain was investigated by peroxidase-antiperoxidase methods using antiserum to rat skeletal muscle parvalbumin. PA-LI was present in non-pyramidal neurons of the cerebral cortices, stellate cells, basket cells and Purkinje cells in cerebellar cortices, and neurons of some nuclei in human brain stem; the distribution of PA-LI in human brain was very similar to that in rat brain. These results indicate that PA-LI is widely distributed in a specific subpopulation of neurons of the human brain.
Third Department of Internal Medicine, University of Yamanashi Medical School, Japan.
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Ohshima
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Onaya
D000368:Aged; D000818:Animals; D001933:Brain Stem / Q000737:chemistry*; D002525:Cerebellar Cortex / Q000737:chemistry*; D002540:Cerebral Cortex / Q000737:chemistry*; D006624:Hippocampus / Q000737:chemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007245:Inferior Colliculi / Q000737:chemistry; D008526:Medulla Oblongata / Q000737:chemistry; D008636:Mesencephalon / Q000737:chemistry; D008875:Middle Aged; D010320:Parvalbumins / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013788:Thalamus / Q000737:chemistry; D015385:Zona Reticularis / Q000737:chemistry
D010320:Parvalbumins