Early SIV encephalopathy.
SIV encephalopathy was studied in rhesus macaques early after intracerebral (IC) or intravenous (IV) inoculation. Although SIV was detected in the brain of all IC-inoculated animals, the CNS showed moderate neuropathological changes. IV-inoculated animals presented a spectrum of brain changes ranging from perivascular infiltrates to multinucleated giant cells. CNS infection was detected as early as seven days post-IV-inoculation, mostly in a perivascular localization. Using combined immunohistochemistry and in situ hybridization, infected cells were shown to express macrophage markers.
Institut Pasteur, Paris, France.
B
B
Hurtrel
L
L
Chakrabarti
M
M
Hurtrel
M A
MA
Maire
D
D
Dormont
L
L
Montagnier
D015526:AIDS Dementia Complex / Q000382:microbiology* / Q000473:pathology; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001921:Brain / Q000382:microbiology* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D005500:Follow-Up Studies; D015967:Gene Expression Regulation, Viral; D007150:Immunohistochemistry; D008253:Macaca mulatta; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000032:analysis; D015531:Radioimmunoprecipitation Assay; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*
D000914:Antibodies, Viral; D012367:RNA, Viral