Effect of intraperitoneal administration of oxygen on the course of experimentally induced peritonitis.
Over the first 3 days of experimentally induced peritonitis, 40 rabbits were given oxygen intraperitoneally (IP) up to a pressure of 3 to 5 mm Hg in the peritoneal cavity at 12-hour intervals. Compared with a control group, significant differences were recorded in the mortality rate within the studied 7-day period of peritonitis (p less than 0.05). In 29 rabbits with intraperitoneal administration of oxygen, the size of the area that formed the inner wall of the abscess cavity was significantly smaller (p less than 0.01) on day 7 of peritonitis than in the control group. The number of samples obtained from the abscesses positive for Clostridium perfringens (p less than 0.05) and for Staphylococcus aureus (p less than 0.001) was significantly lower in rabbits that had received intraperitoneal oxygen than in the control group. The number of samples from the abscesses positive for Escherichia coli and Streptococcus faecalis was significantly lower in the control group than in the group with intraperitoneal administration of oxygen (p less than 0.05). These results indicate that intraperitoneal administration of oxygen has an effect on the mortality rate associated with peritonitis, the size of the intraperitoneal abscess, and the bacterial composition of these abscesses.
Department of Medical Research and Evaluation, Hospital, Nitra, Czechoslovakia.
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Jarábek
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Bednárik
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Mochnác
D000038:Abscess / Q000382:microbiology / Q000628:therapy*; D000818:Animals; D016009:Chi-Square Distribution; D007274:Injections, Intraperitoneal; D010100:Oxygen / Q000008:administration & dosage*; D010538:Peritonitis / Q000382:microbiology / Q000628:therapy*; D011817:Rabbits; D016019:Survival Analysis
D010100:Oxygen