Effect of acute intravenous alcohol on plasma lipoproteins in man.
The effect of acute administration of ethanol was determined on plasma lipoproteins and post-heparin lipolytic activities in six normal subjects. Ethanol was administered intravenously (IV) in a dose of 0.6 g/kg body weight over 1 hour and blood samples were obtained for 4 hours thereafter. In four subjects, the determinations were repeated after the infusion of an isovolumetric amount of saline. Ethanol resulted in a rapid increase in plasma triglycerides, which persisted throughout the study. Ethanol did not result in changes in high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, or apolipoprotein administration of heparin. The increase in triglycerides without changes in HDL-cholesterol after acute ethanol administration may contribute to an increased severity of cardiovascular disease in binge drinkers.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
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L
Mishra
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NA
Le
W V
WV
Brown
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Mezey
D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008049:Lipase / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged
D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008074:Lipoproteins; D000431:Ethanol; D002784:Cholesterol; D008049:Lipase; D008071:Lipoprotein Lipase