Serum concentrations of gentamicin in patients with myelomeningocele.
Gentamicin serum concentrations were studied in 18 paediatric and adult patients. The doses of gentamicin had to be adjusted for 6 of 18 patients to keep peak and trough serum concentrations below 8 and 2 micrograms/ml, respectively. Thus, serum concentrations monitoring of gentamicin may be useful to individualize doses in patients with myelomeningocele. Additional studies are needed to define specific dosage guidelines in patients of varying ages and disease severity for optimal therapy.
College of Pharmacy, Ohio State University, Columbus 43210.
M C
MC
Nahata
D C
DC
McComb
P R
PR
Schad
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D016903:Drug Monitoring; D005260:Female; D005839:Gentamicins / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008591:Meningomyelocele / Q000097:blood*
D005839:Gentamicins