Colorectal carcinoma: an update.
During the last decade important advances have occurred in the fields of understanding genesis, molecular biology, detection of "precancerous data", intervention, and metastatic behaviour of colorectal cancer. An important step forward has been made in adjuvant therapy. Better understanding of 5-fluorouracil metabolism has led to advances in the treatment of metastatic colon cancer. In this review these recent developments as well as future directions are discussed.
Department of Internal Medicine, University Hospital Groningen, The Netherlands.
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Mulder
D000328:Adult; D002277:Carcinoma / Q000209:etiology / Q000628:therapy; D015179:Colorectal Neoplasms / Q000209:etiology / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D011379:Prognosis; D012307:Risk Factors