Contradictory effects of superoxide dismutase after global or regional ischemia in the isolated rat heart.
The effect of superoxide dismutase was investigated in two different models of ischemia and reperfusion in the isolated rat heart: global and regional ischemia. The results of this comparison show that reperfusion arrhythmias after 10 and 15 min of regional ischemia, induced by occlusion of the left coronary artery, can be prevented by SOD confirming the results of other investigators. Paradoxically SOD was without effect after 10 min of global ischemia, obtained by stopping coronary flow completely. After 15 min of global ischemia, SOD induced ventricle fibrillation. Apparently the effect of SOD depends on the model of ischemia and reperfusion that is used.
Department of Biochemistry I, Erasmus University Rotterdam, The Netherlands.
A
A
Voogd
W
W
Sluiter
J F
JF
Koster
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D003327:Coronary Disease / Q000188:drug therapy* / Q000201:enzymology; D004195:Disease Models, Animal; D005609:Free Radicals; D008297:Male; D015425:Myocardial Reperfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000009:adverse effects / Q000494:pharmacology*
D005609:Free Radicals; D013482:Superoxide Dismutase