Effect of calcium channel blocker (diltiazem) on platelet aggregation.
Platelet aggregation with collagen, ADP and sodium arachidonate was significantly inhibited by 0.48 and 0.24 mg/ml of diltiazem but no significant effect occurred with 0.024 mg/ml of diltiazem. It is suggested that the antiplatelet property of diltiazem may be utilized in clinical setting and diltiazem may be tried synergistically with other antiplatelet drugs.
Salam
S R
SR
Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi.
Saxena
R
R
Saraya
A K
AK
D004110:Diltiazem / Q000494:pharmacology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology
D010975:Platelet Aggregation Inhibitors; D004110:Diltiazem