Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism?
Basic fibroblast growth factor, (bFGF), promotes the formation of new blood capillaries and is sequestered and protected by binding to heparan sulfate (HS), both on the cell surface and in the extracellular matrix. Release of HS-bound bFGF by heparin-like molecules and HS-degrading enzymes (i.e., heparanase) provides a novel mechanism for regulation of the growth of capillary blood vessels in normal and pathological situations. The extracellular matrix also serves as a storage depot for other growth factors and enzymes.
Department of Oncology, Hadassah University Hospital, Jerusalem, Israel.
I
I
Vlodavsky
R
R
Bar-Shavit
R
R
Ishai-Michaeli
P
P
Bashkin
Z
Z
Fuks
D002196:Capillaries; D005109:Extracellular Matrix / Q000378:metabolism*; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D005966:Glucuronidase; D006026:Glycoside Hydrolases / Q000378:metabolism; D006493:Heparin / Q000031:analogs & derivatives / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism; D000099175:Heparanase
D016222:Fibroblast Growth Factor 2; D005966:Glucuronidase; D006026:Glycoside Hydrolases; D006493:Heparin; D011509:Proteoglycans; D000099175:Heparanase; C036090:heparin proteoglycan