Superiority of methylprednisolone over dexamethasone for induction of Pneumocystis carinii infection in rats.
Because of difficulties in in vitro cultivation, the basic Pneumocystis carinii studies have been carried out on animal models, mainly on rodents immunosuppressed by corticosteroids. Commonly used dexamethasone and methylprednisolone procedures were evaluated. The intensity of infection in rats was statistically significantly higher after 9 weeks' immunosuppression with methylprednisolone than with dexamethasone.
Department of Anatomy, College of Veterinary Medicine, Helsinki, Finland.
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Sukura
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Soveri
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Lindberg
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D007165:Immunosuppression Therapy / Q000379:methods; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology; D011020:Pneumonia, Pneumocystis / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains
D003907:Dexamethasone; D008775:Methylprednisolone