Antigenic relationships among the rickettsiae of the spotted fever and typhus groups.
Using immunoblots to analyze antigenic relationships among the pathogenic spotted fever and typhus group rickettsiae, I found that the rickettsial lipopolysaccharide (LPS) was a group-specific antigen. All the rickettsiae examined had 135-kDa and 58-kDa protein antigens. The spotted fever rickettsiae and Rickettsia canada had, in addition, 190-kDa protein antigens which were antigenic analogs of previously described protective antigens of R. conorii and R. rickettsii.
Vishwanath
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Laboratory of Intracellular Parasites, NIH, NIAID, Rocky Mountain Laboratories, Hamilton, MT.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology; D015153:Blotting, Western; D002458:Cell Fractionation; D004591:Electrophoresis, Polyacrylamide Gel; D006168:Guinea Pigs; D007106:Immune Sera; D008070:Lipopolysaccharides / Q000276:immunology; D012281:Rickettsia / Q000145:classification* / Q000276:immunology; D012282:Rickettsia Infections / Q000382:microbiology; D012283:Rickettsia prowazekii / Q000145:classification / Q000276:immunology; D012284:Rickettsia rickettsii / Q000145:classification / Q000276:immunology; D012286:Rickettsia typhi / Q000145:classification / Q000276:immunology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007106:Immune Sera; D008070:Lipopolysaccharides