[An 8; 21 chromosome translocation associated leukemia presenting with large intestinal granulocytic sarcoma: a report of two cases].
Two patients of acute myelogenous leukemia (AML) presented with a large intestinal tumor and related symptoms. They had a tumor in the rectum or the ascending colon. Bone marrow cells obtained from both patients showed a karyotype with t(8;21). Chromosomal findings in the former patient has already been reported in detail (Am J Hematol 4, 273, 1978). These findings and reports in the literature indicate that large intestinal tumor may not be rare in AML with an 8;21 translocation. Complete remission was achieved after chemotherapy, when their intestinal tumors disappeared.
Matsunaga
T
T
Saitama Cancer Center Hospital, Hematology Clinic.
Maseki
N
N
Kaneko
Y
Y
Sampi
K
K
Tsuchimochi
T
T
Sakurai
M
M
Hattori
M
M
D000328:Adult; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D003110:Colonic Neoplasms / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D012004:Rectal Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic