Glutathione S-transferase class mu in French alcoholic cirrhotic patients.
The lack of glutathione S-transferase mu (GST mu) was examined in 45 healthy French Caucasians and 45 alcoholic cirrhotic French Caucasians: microsamples of blood were taken and DNA amplified by the polymerase chain reaction. We have concluded that there is no relationship between this genotype and the development of alcoholic cirrhosis in these heavy consumers of ethanol.
Groppi
A
A
Laboratoire de Génétique CNRS UA 542, Talence, France.
Coutelle
C
C
Fleury
B
B
Iron
A
A
Begueret
J
J
Couzigou
P
P
D000328:Adult; D000437:Alcoholism / Q000201:enzymology / Q000235:genetics*; D001483:Base Sequence; D015139:Blotting, Southern; D003854:Deoxyribonucleotides; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008103:Liver Cirrhosis / Q000201:enzymology / Q000235:genetics*; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D003854:Deoxyribonucleotides; D005982:Glutathione Transferase