Early effects of lead on bone marrow cell responsiveness in mice challenged with Listeria monocytogenes.
Listeria monocytogenes challenge of lead-treated mice results in increased mortality. Since macrophage development constitutes the initial phase of the immune response to L. monocytogenes, bone marrow and spleens from Pb-treated mice that were infected with L. monocytogenes were analyzed for their ability to form colonies when exposed to the macrophage growth factor CSF-1. Serum colony-stimulating activity also was evaluated. Data obtained indicate the Pb exposure results in decreased responsiveness of bone marrow and spleen cells to CSF-1 while colony-stimulating activity in serum rises. This lack of bone marrow-derived macrophage development may contribute to the increased mortality observed with L. monocytogenes challenged. Pb-treated mice.
Albany Medical College, Department of Microbiology and Immunology, New York 12208.
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Kowolenko
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Tracy
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Lawrence
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000382:microbiology; D001854:Bone Marrow Cells; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D005260:Female; D005434:Flow Cytometry; D007854:Lead / Q000633:toxicity*; D008089:Listeria monocytogenes; D008088:Listeriosis / Q000382:microbiology / Q000503:physiopathology*; D008099:Liver / Q000382:microbiology; D051379:Mice; D008808:Mice, Inbred CBA; D010641:Phenotype; D013154:Spleen / Q000166:cytology
D003115:Colony-Stimulating Factors; D007854:Lead