Airway obstruction and bronchial hyperresponsiveness in left ventricular failure and mitral stenosis.
Small and large airways narrow in LVF and the term cardiac asthma is often used. However, current usage of this term is inconsistent and its meaning is therefore ambiguous. The term is better avoided despite several emerging similarities with bronchial asthma. Airway narrowing may be precipitated by acute elevation of pulmonary or bronchial vascular pressures. This appears to be mainly due to reflex bronchoconstriction. The afferents of this reflex are C-fibers with their endings in the lung parenchyma, bronchi, and pulmonary blood vessels and RAR in the larger airways, and they run in the vagus nerves, as do the efferent bronchoconstrictor fibers. Chronic elevation of pulmonary vascular pressures, as in mitral stenosis, are also associated with airway narrowing. Pulmonary edema (in the absence of vascular hypertension) also causes reflex bronchoconstriction. Bronchial responsiveness to bronchoconstrictor drugs is increased in LVF, partly, at least, due to reflex mechanisms. Bronchial mucosal swelling may also contribute. Narrowing by nonreflex mechanisms definitely occurs and there is direct evidence that decreased lung volume caused by pulmonary edema may cause this. There is little evidence for bronchial narrowing due to the mechanical effect of peribronchial edema, or by swelling of the bronchial mucosa. However, edema foam may terminally cause grave obstruction. Patients with LVF are commonly treated with bronchodilator drugs, but the basis for this approach needs further clarification.
Department of Medicine, Charing Cross and Westminster Medical School, London, United Kingdom.
P D
PD
Snashall
K F
KF
Chung
D000402:Airway Obstruction / Q000209:etiology* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000209:etiology* / Q000503:physiopathology; D016084:Bronchoconstriction / Q000502:physiology; D004418:Dyspnea, Paroxysmal / Q000209:etiology / Q000503:physiopathology; D006333:Heart Failure / Q000150:complications* / Q000503:physiopathology; D006352:Heart Ventricles; D006801:Humans; D008946:Mitral Valve Stenosis / Q000150:complications* / Q000503:physiopathology; D009626:Terminology as Topic