Effect of the microbial constituents, LPS and BCG, on the glycosaminoglycans of chondrocyte cultures.
Earlier we reported that articular chondrocytes in monolayer culture produce pericellular proteoglycans both with short and long half lives, T-1 and T-2 (Kittlick et al. 1991 b). Now monolayer cultures have been investigated to assess the influence on the metabolism of pericellular proteoglycans or glycosaminoglycans by lipopolysaccharide of E. coli and S. typhimurium as well as by Bacillus Calmette-Guérin.
Friedrich Schiller University Jena, Institute of Pathology, F.R.G.
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Kittlick
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Engelmann
D000818:Animals; D002358:Cartilage, Articular / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D004926:Escherichia coli / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000378:metabolism / Q000502:physiology*; D009163:Mycobacterium bovis / Q000502:physiology*; D011509:Proteoglycans / Q000378:metabolism; D011817:Rabbits; D013455:Sulfur / Q000378:metabolism; D013462:Sulfur Radioisotopes
D006025:Glycosaminoglycans; D008070:Lipopolysaccharides; D011509:Proteoglycans; D013462:Sulfur Radioisotopes; D013455:Sulfur