The distribution of the HLA-DQ alpha alleles and genotypes in the Finnish population as determined by the use of DNA amplification and allele specific oligonucleotides.
Allele and genotype frequencies for the HLA-DQ alpha locus were determined for use in forensic analyses and paternity tests in Finland. The polymerase chain reaction (PCR) and the reverse dot blot format were employed to detect 6 different HLA-DQ alpha alleles. All 6 HLA-DQ alpha alleles were detected among the 112 unrelated individuals with allele frequencies ranging from 5.8% to 32.6%. The distribution of the observed genotypes is in Hardy-Weinberg equilibrium. Additionally, this Finnish population sample is statistically similar to 2 other Caucasian sample populations. The power of discrimination of this system in the Finnish population sample is 0.92, suggesting this method may prove suitable for identification purposes.
National Public Health Institute, Helsinki, Finland.
A
A
Sajantila
M
M
Ström
B
B
Budowle
P J
PJ
Tienari
C
C
Ehnholm
L
L
Peltonen
D000483:Alleles; D004247:DNA / Q000032:analysis*; D005387:Finland; D005554:Forensic Medicine / Q000379:methods*; D005784:Gene Amplification; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D009841:Oligonucleotides / Q000235:genetics; D044465:White People / Q000235:genetics*
D006683:HLA-DQ Antigens; D009841:Oligonucleotides; D004247:DNA