[Remarkable improvement of anemia by administration of recombinant human erythropoietin in a patient with aplastic anemia].
A 69-year-old female was admitted for pancytopenia. The hematological examination showed leukocytes 1,800/microliters, hemoglobin 5.3 g/dl and platelets 9.6 x 10(4)/microliters. A bone marrow aspiration revealed hypoplasia, but no abnormal cells. Serum erythropoietin titer was 5,100 mU/ml. Diagnosis of aplastic anemia was made. She received 400 ml of blood transfusion twice, and was then treated with recombinant human erythropoietin (rHuEPO) (12,000 U/day) three times a week for eight weeks. Hemoglobin level gradually increased to the level of 12.0 g/dl. This case suggests that there are some cases of aplastic anemia which can respond to treatment with rHuEPO.
Misago
M
M
First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health.
Mori
N
N
Hoshuyama
T
T
Tsukada
J
J
Morimoto
I
I
Oda
S
S
Chiba
S
S
Eto
S
S
D000368:Aged; D000741:Anemia, Aplastic / Q000628:therapy*; D004334:Drug Administration Schedule; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use
D011994:Recombinant Proteins; D004921:Erythropoietin