Temperature-induced stress abrogates co-stimulatory function in antigen-presenting cells.
This study examines the effect of heat-induced stress on the function of splenic antigen-presenting cells. Heat shock (at 41 degrees C, 45 degrees C) profoundly inhibits the ability of this population to stimulate antigen-specific proliferation in ex vivo, or short-term cultures of T cells. This inhibition is not due to the release of suppressor factors from the antigen-presenting cells, nor to a lack of interleukin 1. Comparison of the effect of heat shock on presentation to a T cell hybridoma suggest that heat shock may affect the ability of antigen-presenting cells to deliver a co-stimulatory signal to the T cell. The implication of these findings in terms of the regulation of autoimmune phenomena is discussed.
I.C.R.F. Tumour Immunology Unit, Department of Biology, University College, London, GB.
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G
Kuperberg
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Ellis
J
J
Marcinkiewicz
B M
BM
Chain
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006358:Hot Temperature; D007375:Interleukin-1 / Q000494:pharmacology; D007376:Interleukin-2 / Q000096:biosynthesis; D007377:Interleukin-3 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D051379:Mice; D008811:Mice, Inbred DBA; D010047:Ovalbumin / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013312:Stress, Physiological / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D007375:Interleukin-1; D007376:Interleukin-2; D007377:Interleukin-3; D011948:Receptors, Antigen, T-Cell; D010047:Ovalbumin