[The detection of mutations arising in human populations].
The problem on screening of de novo mutations, arising in populations, by the method of search for rare protein variants has been critically discussed. The data on monomorphic loci and rare variants of human blood proteins, and platelet monoamine oxidase previously not studied in terms of populations are presented. A method is suggested to screen mutations, using restriction analysis of mitochondrial DNA in mouse populations.
Nazarova
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D000818:Animals; D001792:Blood Platelets / Q000201:enzymology; D001798:Blood Proteins / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D004787:Environmental Pollution / Q000009:adverse effects; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005828:Genetics, Population / Q000187:drug effects; D006801:Humans; D051379:Mice; D008995:Monoamine Oxidase / Q000235:genetics; D009154:Mutation / Q000187:drug effects / Q000235:genetics*; D015183:Restriction Mapping; D014586:USSR
D001798:Blood Proteins; D004272:DNA, Mitochondrial; D008995:Monoamine Oxidase
Obnaruzhenie mutatsiĭ, voznikaiushchikh v populiatsiiakh cheloveka.