Reduction of cat eye movements using retrobulbar botulinum toxin.
We studied the effects of a single retrobulbar injection of Botulinum toxin on the motility of cat eyes. Four cats were sedated and the opposite eye served as a control. Eye movements were plotted by reflecting a laser beam from a mirror fixed to the cornea. We found the mean degrees of deviation per eye per day and summarized these results as mean degrees of deviation per eye per week +/- standard deviation. Statistical analysis was accomplished using Student's t test for independent measures, since measurement of the treated eye pairs was done in a randomized manner on different test days. (table; see text) These results indicate that a single retrobulbar dose of Botulinum toxin can produce a paralysis of the ocular musculature lasting in excess of four weeks in a specific and reproducible manner. In addition, this methodology should prove useful in future experiments in which ocular motility might prove to be a technical concern.
Zimm
J
J
Loyola University Chicago, Department of Ophthalmology, Maywood, Illinois.
Yanik
G M
GM
Evans
L
L
Marchese
A
A
D000818:Animals; D001905:Botulinum Toxins / Q000494:pharmacology*; D002415:Cats; D004584:Electronystagmography; D005133:Eye Movements / Q000502:physiology*; D007834:Lasers; D008722:Methods; D009801:Oculomotor Muscles; D009915:Orbit
D001905:Botulinum Toxins