Traditional medicinal plants of Thailand. XVII. Biologically active constituents of Plumeria rubra.
The compounds 1-6 were isolated from the heartwood of Plumeria rubra, following bioactivity-directed fractionation. Plumericin 1 and isoplumericin 2 displayed molluscicidal, cytotoxic and antibacterial activity, 4-hydroxyacetophenone 3 was weakly cytotoxic, whereas the remaining glycosidic isolates (plumieride, 4; 13-O-coumaroylplumieride, 5; protoplumericine A, 6) were inactive in all test systems.
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
M O
MO
Hamburger
G A
GA
Cordell
N
N
Ruangrungsi
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000627:therapeutic use; D002460:Cell Line; D007192:Indenes / Q000302:isolation & purification* / Q000627:therapeutic use; D039823:Iridoids; D007941:Leukemia P388 / Q000188:drug therapy; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013785:Thailand
D000972:Antineoplastic Agents, Phytogenic; D007192:Indenes; D039823:Iridoids; C068511:plumericin