Mitoxantrone toxicity on Ehrlich ascites tumour cells: inhibition of the transplasma membrane redox activity.
This study focused on the potent cytotoxic effect that mitoxantrone produces on Ehrlich ascites tumour cells. Host mice treated with mitoxantrone showed a life span three times higher than control non-treated host mice. Mitoxantrone also showed a potent cytotoxic effect on Ehrlich cells incubated in vitro for only a few hours. Studies on the effect of mitoxantrone on a plasma membrane redox system showed that mitoxantrone inhibits this activity, which is apparently related to cell proliferation.
Laboratorio de Bioquimica, Facultad de Ciencias, Universidad de Málaga, Spain.
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Medina
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Luque
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Núñez De Castro
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D005260:Female; D051379:Mice; D008942:Mitoxantrone / Q000633:toxicity*; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D010084:Oxidation-Reduction; D014407:Tumor Cells, Cultured
D008942:Mitoxantrone; D009247:NADH, NADPH Oxidoreductases; C014227:ferricyanide reductase