[A chronobiological approach to evaluating the individual reactivity of animals in a practical psychopharmacological experiment].
As shown numerous data from our laboratory in time course of different behavioral tests (active avoidance response, re-learning in Y-maze etc.) and psychopharmacological effects (amphetamine-induced stereotypy, haloperidol catalepsy) short period (minute or second range) fluctuations are presented. By means of their account rhythmical patterns may be obtained individually for each animals. On this basis all animals can be typified such that can serve as a safe prognostic criterion of individual pharmacological sensitivity and speed of development of development of tolerance to psychotropic drugs.
Arushanian
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EB
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002909:Chronobiology Phenomena / Q000187:drug effects*; D010507:Periodicity; D011600:Psychopharmacology / Q000379:methods; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012107:Research Design; D013997:Time Factors
D011619:Psychotropic Drugs
Khronobiologicheskiĭ podkhod k otsenke individual'noĭ reaktivnosti zhivotnykh v praktike psikhofarmakologicheskogo éksperimenta.