HLA-DPB1*0301 is a major risk factor for rheumatoid factor-negative adult rheumatoid arthritis.
HLA-DPB1 alleles were determined using the polymerase chain reaction and allele-specific oligonucleotide probes in Caucasoid patients with rheumatoid arthritis (RA) and in healthy controls. DPB1*0301 was found to be increased in seronegative patients (50.0% versus 10.8% in controls; relative risk = 8.3, P less than 0.0001). With our previous finding that DPB1*0301 is increased in seronegative children with polyarticular-onset arthritis, the results suggest a relationship between this disease and seronegative RA in adults.
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8886.
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Olsen
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Pincus
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Stastny
D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D005784:Gene Amplification; D008040:Genetic Linkage; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D016133:Polymerase Chain Reaction; D012217:Rheumatoid Factor / Q000032:analysis*; D012307:Risk Factors; D012698:Serologic Tests
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D012217:Rheumatoid Factor