[Effects of neutron-gamma or gamma irradiation on plasma coagulation factors. Effect of a substitution treatment].
Neutron-gamma irradiation of the baboon at lethal dose altered the plasma clotting factors and induced a fibrinoformation alteration which occurred shortly before death. These disturbances, which were not found after gamma irradiation, could explain the importance of the haemorrhagic syndrome. Treatment by P.P.S.B. (factors II, VII, X and IX) counteracted the alterations of the plasma clotting factors, but had no influence on the lethality nor on the fibrinoformation alteration which seems to be an important cause of death.
Unités de Radiopathologie et de Radioprotection, Centre de Recherches du Service de Santé des Armées, La Tronche.
J C
JC
Mestries
S
S
Martin
D
D
Janodet
F
F
Herodin
P
P
Gourmelon
M
M
Fatome
D000818:Animals; D001779:Blood Coagulation Factors / Q000528:radiation effects* / Q000627:therapeutic use*; D005340:Fibrinogen / Q000032:analysis / Q000528:radiation effects; D005342:Fibrinolysis / Q000528:radiation effects; D005720:Gamma Rays; D007928:Lethal Dose 50; D008297:Male; D009502:Neutrons; D010215:Papio
D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates; D005340:Fibrinogen
Effets de l'irradiation neutron-gamma ou gamma sur les facteurs plasmatiques de coagulation. Effet d'un traitement de substitution.