Evaluation of DNA damage induced by norfloxacin in liver and kidney of adult rats and in fetal tissues after transplacental exposure.
Norfloxacin, a recently developed antimicrobial fluoroquinolone, was investigated for DNA-damaging activity in rat liver and kidney. After oral administration of single doses ranging from 1 to 8 mmole/kg, DNA fragmentation was absent in liver and kidney both 2 and 6 h after treatment. However, when administered to pregnant rats, the highest doses produced a detectable amount of DNA damage in fetal tissues. This damage appears to be an aspecific consequence of maternal and fetal toxicity rather than a specific genotoxic effect.
Institute of Pharmacology, University of Genoa, Italy.
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Pino
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Maura
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F
Villa
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Masciangelo
D000818:Animals; D004249:DNA Damage; D005260:Female; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008431:Maternal-Fetal Exchange; D009643:Norfloxacin / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D009643:Norfloxacin