An experimental osteosarcoma of the athymic nude rat.
In this report we describe an experimental osteogenic sarcoma that had been radiation-induced on Sprague-Dawleys by Delbrück in 1980. We transplanted it to 120 athymic nude rats achieving take rates of 100%. The tumor doubling time was 10.5 days. The osteosarcoma on athymic rats thus proliferated extraordinarily well compared to other known models. Pulmonary metastases were demonstrated in 100% of the examined animals. Pathological examinations revealed morphological similarities to human osteosarcoma and no signs of anaplasia.
Institute for Anatomy I, Technical University of Aachen, FRG.
J G
JG
Witzel
A
A
Prescher
D000818:Animals; D004195:Disease Models, Animal; D008175:Lung Neoplasms / Q000556:secondary; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology; D012516:Osteosarcoma / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D011923:Rats, Nude; D015996:Survival Rate; D013997:Time Factors