Molecular interactions modulating neuronal survival and growth.
The extracellular environment of the neuron provides a heterogeneous milieu of survival and growth modulating molecular species subserving regulatory signals that operate in development, mediate activity-dependent enduring changes in synaptic connectivity, and promote or inhibit survival and axonal regeneration following insult. Parallel distributed processing networks in neurons, activated by these molecular species, can likely be recruited selectively to serve specific needs of the organism.
Riopelle
R J
RJ
Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Dow
K E
KE
Verge
V M
VM
Richardson
P M
PM
D000818:Animals; D002470:Cell Survival; D006133:Growth Substances / Q000494:pharmacology / Q000502:physiology*; D009414:Nerve Growth Factors / Q000502:physiology; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*
D006133:Growth Substances; D009414:Nerve Growth Factors