[Pathologic study on megakaryocytes in chronic myeloproliferative disorders].
Megakaryocytes in 42 cases of Chronic Myeloproliferative Disorders were studied pathologically, and a classification of these disorders was suggested. Abnormal megakaryocytes were classified as immature, mature, naked-nuclear, micro-, giant, multinucleated and dysplastic types based on the degree of maturity, the number of ploidy, and the presence or absence of atypia. Immunohistochemical studies indicated that antibodies against platelet glycoprotein Ib, IIb/IIIa as well as VIII R:Ag are highly specific for the detection of megakaryocytes, especially the morphologically unrecognizable ones. With regard to the identification of micromegakaryocytes, nuclear size, shape and degree of cytoplasmic maturity were emphasized. In addition to the classification, the clinic-pathological significance of abnormal megakaryocytes is discussed.
Lin
N
N
Electron Microscopy Laboratory, Fujian Medical College, Fuzhou.
Liang
P
P
D000911:Antibodies, Monoclonal; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology; D008533:Megakaryocytes / Q000473:pathology; D009196:Myeloproliferative Disorders / Q000145:classification / Q000473:pathology*; D010980:Platelet Membrane Glycoproteins / Q000276:immunology; D014841:von Willebrand Factor / Q000276:immunology
D000911:Antibodies, Monoclonal; D010980:Platelet Membrane Glycoproteins; D014841:von Willebrand Factor