On the conversion of thymidine phosphate bromohydrins to thymidine phosphates: a model reaction for the repair of oxidized nucleotides.
Bromohydrins (12, 13, and 14), which were oxidatively damaged products of thymidine nucleotides, were repaired by the action of sunlight (2700 lux) or heat via a radical mechanism to regenerate the original nucleotides (8,9, and 10). A significant effect of 3',5'-phosphate linkage on the repair reactions to natural type of thymidine nucleotide was proposed.
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
F
F
Yoneda
T
T
Akiyama
M
M
Ohno
R
R
Yanada
T
T
Harayama
D000438:Alcohols; D004260:DNA Repair; D005609:Free Radicals; D005663:Furans; D006358:Hot Temperature; D010084:Oxidation-Reduction; D012997:Solvents; D013472:Sunlight; D013942:Thymine Nucleotides
D000438:Alcohols; D005609:Free Radicals; D005663:Furans; D012997:Solvents; D013942:Thymine Nucleotides; C023963:bromohydrins; C018674:tetrahydrofuran