The effects of ioxaglate 320, iohexol 350, and iopamidol 370 on erythrocyte aggregation.
The authors report a randomized, double-blind prospective trial comparing the effects of nonionic with ionic low-osmolar contrast media on erythrocyte aggregation. The study group comprised 40 consecutive patients with pathology necessitating selective angiography. Patients were examined using either ioxaglate 320, iohexol 350, or iopamidol 370. Erythrocyte aggregation was assessed both macroscopically and microscopically. Erythrocyte aggregation occurred more frequently in the iopamidol group (13 of 45 samples examined) than in the iohexol (4 of 46) or ioxaglate (5 of 51) groups (P = .002).
Department of Radiology, St. Vincent's Hospital, Dublin 4, Ireland.
R
R
Hayes
T
T
Mahon
J
J
Masterson
A
A
Owens
D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007472:Iohexol / Q000494:pharmacology*; D007479:Iopamidol / Q000494:pharmacology*; D007485:Ioxaglic Acid / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D007472:Iohexol; D007479:Iopamidol; D007485:Ioxaglic Acid