Ectopic production of calciotropic peptides.
Tumors are frequently associated with factors that affect bone cell function and calcium homeostasis. As a result, many patients with cancer develop paraneoplastic syndromes. The commonest is hypercalcemia of malignancy. Other related paraneoplastic syndromes are hypocalcemia, hypophosphatemia, and osteomalacia.
Mundy
G R
GR
Department of Medicine, University of Texas Health Science Center, San Antonio.
D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D002402:Cathepsin D / Q000502:physiology; D004792:Enzyme Precursors / Q000502:physiology; D006729:Hormones, Ectopic / Q000502:physiology*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000503:physiopathology; D006996:Hypocalcemia / Q000209:etiology / Q000503:physiopathology; D007375:Interleukin-1 / Q000502:physiology; D008233:Lymphotoxin-alpha / Q000502:physiology; D010018:Osteomalacia / Q000209:etiology; D009384:Paraneoplastic Endocrine Syndromes / Q000150:complications; D010281:Parathyroid Hormone / Q000502:physiology; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000502:physiology; D016211:Transforming Growth Factor alpha / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D004792:Enzyme Precursors; D006729:Hormones, Ectopic; D007375:Interleukin-1; D008233:Lymphotoxin-alpha; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D016211:Transforming Growth Factor alpha; D014409:Tumor Necrosis Factor-alpha; C058345:procathepsin D; D002402:Cathepsin D; D002118:Calcium