Ultrastructural differences between the cells of the medical collateral and the anterior cruciate ligaments.
The anterior cruciate ligament (ACL) does not heal after an interstitial tear, in contrast to the medial collateral ligament (MCL), whose interstitial tears heal readily. The light microscopic and ultrastructural differences between the cells of the two ligaments were studied in rabbit knees to observe the healing characteristics of the two ligaments. A rabbit knee was chosen because the rabbit ACL, like that of humans, does not heal following interstitial injury. The cells populating the MCL have the characteristics of fibroblasts. The cells of the ACL resemble fibrocartilage cells. The phenotypic differences in the cells of the two ligaments may be important determinants of the differences in healing.
Division of Orthopaedics and Rehabilitation, University of California, San Diego.
R M
RM
Lyon
W H
WH
Akeson
D
D
Amiel
L R
LR
Kitabayashi
S L
SL
Woo
D000818:Animals; D016118:Anterior Cruciate Ligament / Q000502:physiology / Q000648:ultrastructure; D003094:Collagen / Q000032:analysis; D005347:Fibroblasts / Q000648:ultrastructure; D005353:Fibronectins / Q000032:analysis; D008022:Ligaments / Q000502:physiology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D015388:Organelles / Q000648:ultrastructure; D011817:Rabbits; D014945:Wound Healing / Q000502:physiology*
D005353:Fibronectins; D003094:Collagen