Ovarian vein sampling in rapidly progressing virilization. A case report.
A woman presented with progressive hirsutism, deepening of the voice, clitoromegaly and increased libido. The preoperative serum testosterone level was 2,042 ng/dL. The intraoperative ovarian venous blood testosterone levels were 56,327 ng/dL on the left and 1,417 on the right. After a bilateral salpingo-oophorectomy, the serum testosterone level was 20.7 ng/dL. Initial pathologic examination of the ovaries revealed no potential source of testosterone, but reexamination revealed a pure lipoid cell tumor. Intraoperative ovarian vein androgen measurements can be helpful in establishing a histopathologic diagnosis in cases of microscopic virilizing ovarian neoplasms. Ovarian vein sampling for androgen was essential in locating this patient's microscopic tumor.
DeFreitas
E A
EA
Department of Obstetrics and Gynecology, Portsmouth Naval Hospital, Virginia.
Dudzinski
M R
MR
LaRocque
J C
JC
Coddington
C C
CC
D000314:Adrenal Rest Tumor / Q000150:complications / Q000175:diagnosis*; D000328:Adult; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis*; D010052:Ovariectomy; D010053:Ovary / Q000098:blood supply; D013739:Testosterone / Q000097:blood*; D014680:Veins; D014770:Virilism / Q000175:diagnosis* / Q000209:etiology
D013739:Testosterone