Efficacy and toxicity of VAC chemotherapy (vincristine, doxorubicin, and cyclophosphamide) in dogs with hemangiosarcoma.
Fifteen dogs with hemangiosarcoma were treated with a combination of vincristine, doxorubicin, and cyclophosphamide after incisional or excisional biopsy. The median survival for all fifteen dogs was 172 days (mean survival = 316 days). The median survival for those dogs with splenic hemangiosarcoma was 145 days (mean survival = 271 days) as compared with previously published median survival times in dogs with splenic hemangiosarcoma treated with surgery alone of 19 to 65 days. Toxicities included neutropenia (11/15), severe gastroenteritis (4/15), cardiotoxicity (3/15), and sepsis (2/15). The authors conclude that vincristine, doxorubicin, and cyclophosphamide chemotherapy may be an efficacious treatment modality in dogs with hemangiosarcoma and is associated with acceptable toxicity.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.
A S
AS
Hammer
C G
CG
Couto
J
J
Filppi
D
D
Getzy
K
K
Shank
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D003609:Dactinomycin / Q000008:administration & dosage / Q000009:adverse effects; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D005759:Gastroenteritis / Q000139:chemically induced / Q000662:veterinary; D006321:Heart / Q000187:drug effects; D006394:Hemangiosarcoma / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000662:veterinary; D010859:Pigmentation Disorders / Q000139:chemically induced / Q000662:veterinary; D012878:Skin Neoplasms / Q000188:drug therapy / Q000662:veterinary; D013160:Splenic Neoplasms / Q000188:drug therapy / Q000662:veterinary; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide