Drosophila 60A gene, another transforming growth factor beta family member, is closely related to human bone morphogenetic proteins.
The 60A gene, a member of the transforming growth factor beta superfamily of signaling proteins, has been identified in Drosophila melanogaster. From its inferred protein sequence we predict the precursor is secreted and processed to release a growth factor-like molecule. The 60A gene is expressed throughout development with peaks of transcription during early embryogenesis, in pupae, and in adult males. The putative 60A protein shows greater sequence similarity to three vertebrate family members (human bone morphogenetic proteins 5, 6, and 7) than to its only Drosophila relative, the protein product of the decapentaplegic (dpp) gene. This observation suggests that the duplication event that gave rise to the two transforming growth factor beta-like proteins in Drosophila predates the divergence of chordates and arthropods.
Department of Cellular, Harvard University, Cambridge, MA 02138.
K A
KA
Wharton
G H
GH
Thomsen
W M
WM
Gelbart
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019485:Bone Morphogenetic Proteins; D004247:DNA / Q000235:genetics; D004330:Drosophila / Q000196:embryology / Q000235:genetics* / Q000254:growth & development; D015698:Genomic Library; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D009841:Oligonucleotides; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics*; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D016212:Transforming Growth Factor beta / Q000235:genetics*
D019485:Bone Morphogenetic Proteins; D009841:Oligonucleotides; D011506:Proteins; D016212:Transforming Growth Factor beta; D004247:DNA