Absorption of oral ciprofloxacin in a patient with cardiogenic shock.
Congestive heart failure and cardiogenic shock can alter the absorption process of some drugs. The absorption of ciprofloxacin has been studied in several disease states, but the effect of cardiogenic shock on its absorption is unknown. A 63-year-old man had a large myocardial infarction complicated by cardiogenic shock. When he began taking ciprofloxacin for pneumonia, he had renal and cardiac failure. Ciprofloxacin 500 mg was administered every 24 hours by nasogastric tube. Blood samples were collected 5 minutes prior to the second dose (20 hrs after the initial dose) and then regularly until 11 hours after the dose. Samples were analyzed using high-performance liquid chromatography. The trough concentration 20 hours after the initial dose was 3.7 micrograms/ml, and the serum concentrations after the second dose went from 5.6 to 4.94 micrograms/ml over the 11-hour sampling period. The peak concentration of 5.6 micrograms/ml occurred within 30 minutes after ciprofloxacin administration. It can be concluded from this case study that ciprofloxacin was adequately absorbed in this patient with multiple organ failure.
Ujhelyi
M R
MR
Department of Pharmacy, Hartford Hospital, CT 06118.
Sullivan
M
M
Nightingale
C
C
D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006352:Heart Ventricles; D006801:Humans; D007408:Intestinal Absorption; D007441:Intubation, Gastrointestinal; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000150:complications; D009203:Myocardial Infarction / Q000150:complications; D012770:Shock, Cardiogenic / Q000378:metabolism* / Q000628:therapy; D013610:Tachycardia / Q000150:complications
D002939:Ciprofloxacin