Prospective study of the use of vasoconstrictor and saline in septal surgery for infiltration.
Vasoconstrictor agents are often used to reduce bleeding and hence improve the operative field in surgery. These agents are potentially dangerous. A trial was undertaken to compare the use of adrenaline 1:80,000 with saline alone as an infiltrating agent in 30 consecutive patients undergoing septoplasty under general anaesthesia. This study, based on a small number of patients can draw no firm conclusions. There are no really dramatic differences between 1:80,000 adrenaline and saline, in terms of blood loss, operative time and the condition of the operative field between the two groups. However, there is a possibility that there are substantial differences which, because of the variability of these outcomes, could not be detected in a study as small as this. It is recommended that a randomized trial involving patients is used to answer the question.
Vanniasegaram
I
I
D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D004837:Epinephrine / Q000627:therapeutic use*; D006801:Humans; D009300:Nasal Septum / Q000601:surgery*; D011446:Prospective Studies; D012965:Sodium Chloride / Q000627:therapeutic use; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
D014662:Vasoconstrictor Agents; D012965:Sodium Chloride; D004837:Epinephrine