[Insulin analogs in 1991].
Despite multiple injections of soluble insulin, it remains impossible to perfectly simulate physiological post-prandial plasma insulin profile. Moreover, crystal suspensions of very long-acting insulin show wide variations in the kinetics of crystal dissolving and therefore in biological activity. These data have lead to the development of insulin analogues, either very rapid-acting or long-acting, in order to avoid these disadvantages. This study focuses on the in vitro characteristics, the biological effects in animals, and the clinical effects in healthy subjects and in diabetic patients of the analogues having therapeutic potential.
Service d'Endocrinologie-Diabétologie-Nutrition, Hôpital Jean-Verdier, Bondy.
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Valensi
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JR
Attali
D000595:Amino Acid Sequence; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy; D006801:Humans; D007328:Insulin / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D008969:Molecular Sequence Data
D001786:Blood Glucose; D007328:Insulin
Les analogues de l'insuline en 1991.