[Preliminary evaluation of inoculation of hepatitis B vaccine in normal adult subjects].
A total of 107 subjects in population without HBsAg, anti-HBs and anti-HBc were inoculated with hepatitis B vaccine in month 0, 1, 6, respectively and followed up for three years. Seven months after the administration of first dose of vaccine response rate of anti-HBs was 94.4%, of which 68.2% had a S/N ratio greater than 10. Three years later the response rate of anti-HBs dropped to 75.7% and the rate of S/N ratio 10 fell to 46.7%, 20 subjects turned negative for anti-HBs and one turned positive for HBsAg. During the same period, of 124 adults who were hepatitis B virus markers negative and were not inoculated, 14 became HBsAg-positive (ALT increased in 3 of them) and 3 turned anti-HBs positive.
Department of Infectious Diseases, Nangfang Hospital, Guangzhou.
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Wang
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D014761:Viral Hepatitis Vaccines
D006510:Hepatitis B Antibodies; D014761:Viral Hepatitis Vaccines