Reversal of primary liver graft non-function using prostaglandins.
Primary graft non-function remains one of the most life-threatening problems after liver transplantation. Its etiology is still unclear. Liver retransplantation is the only therapeutic alternative to this problem. The PGE1 series of prostaglandins have recently been successfully used in the treatment of transplanted organ dysfunction. In this paper we describe a case of primary graft non-function successfully treated with continuous infusion of prostaglandin PGE1, and we briefly discuss the pathogenetic and therapeutic hypotheses.
Grazi
G L
GL
2nd Department of Surgery, University of Bologna, Ospedale S. Orsola, Italy.
Mazziotti
A
A
Sama
C
C
Stefanini
G F
GF
Gozzetti
G
G
D000527:Alprostadil / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D016031:Liver Transplantation / Q000502:physiology; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*
D000527:Alprostadil