Stimulatory action of calcium L-threonate on ascorbic acid uptake by a human T-lymphoma cell line.
The effects of preincubation of human T-lymphoma cells with increasing concentrations of calcium L-threonate on the uptake of L-[1-14C]ascorbic acid were examined. Calcium L-threonate (0-1,000 mg%) stimulated ascorbic acid (1.25 mg%) uptake in a dose-dependent manner. These results indicate that calcium threonate and possibly other ascorbic acid metabolites have biological activity and potential pharmacological applications.
Fay
M J
MJ
Department of Pharmacology, University of Mississippi School of Pharmacy, University 38677.
Verlangieri
A J
AJ
D000704:Analysis of Variance; D001205:Ascorbic Acid / Q000493:pharmacokinetics*; D002087:Butyrates / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016399:Lymphoma, T-Cell / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000378:metabolism
D002087:Butyrates; C011369:threonic acid; D001205:Ascorbic Acid