A case of mixed lineage acute non-lymphocytic leukemia with t(5;12)(p13;p13).
A two-year-old boy had mixed lineage acute non-lymphocytic leukemia (ANLL) with a 46,XY, t(5;12)(p13;p13) karyotype. He was admitted to the hospital with fever and petechiae. Morphological and cytochemical characteristics showed the blasts to meet the standard French-American-British criteria for M1, but surface marker analysis showed the blasts to express both myeloid (CD33: 91.3%) and T-cell (CD2: 82.3%, CD7: 97.9%) antigens. The boy was treated with an ANLL protocol, and successfully brought to a remission which has continued for more than 30 months.
Shimizu
S
S
Department of Pediatrics, Keiyu General Hospital, Yokohama.
Tsunematsu
Y
Y
Fujimoto
J
J
Mizutani
S
S
Kaneko
Y
Y
D000943:Antigens, Differentiation / Q000032:analysis; D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D008297:Male; D012074:Remission Induction; D014178:Translocation, Genetic
D000943:Antigens, Differentiation; D004273:DNA, Neoplasm