The complete amino acid sequence of bovine antithrombin (ATIII).
Bovine antithrombin (ATIII) is a glycoprotein of Mr 56,600. Its primary structure was established using peptide sequences from five different digests. Bovine ATIII exhibits four glcosylation sites as well as human ATIII. The primary structures of bovine and human ATIII were compared: all the residues required for the integrity of the heparin-binding domain are strictly conserved. However, there are differences in the secondary structures of both proteins, bovine and human ATIII.
Mejdoub
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Laboratoire de Biochimie, Centre National de la Recherche Scientifique, Strasbourg, France.
Le Ret
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Boulanger
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Maman
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Choay
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Reinbolt
J
J
D000478:Alkylation; D000595:Amino Acid Sequence; D000818:Animals; D000990:Antithrombin III / Q000737:chemistry*; D001665:Binding Sites; D002417:Cattle; D003488:Cyanogen Bromide; D010450:Endopeptidases; D006031:Glycosylation; D006493:Heparin / Q000378:metabolism; D006801:Humans; D008666:Metalloendopeptidases; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010446:Peptide Fragments / Q000737:chemistry; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid; D012697:Serine Endopeptidases; D000515:alpha 1-Antitrypsin / Q000737:chemistry
D010446:Peptide Fragments; D000515:alpha 1-Antitrypsin; D000990:Antithrombin III; D006493:Heparin; D010450:Endopeptidases; D012697:Serine Endopeptidases; C028344:glutamyl endopeptidase; D008666:Metalloendopeptidases; C058921:endoproteinase Asp-N; D003488:Cyanogen Bromide