[Effect of ulinastatin on microcirculation under excessive hemorrhage and fluid therapy].
Microcirculation during excessive hemorrhage and fluid therapy under anesthesia with or without associated treatment by ulinastatin (urinary trypsin inhibitor) was studied by using the rabbit ear chamber. Sixteen rabbits were divided into 2 groups; 8 rabbits without ulinastatin treatment (C group) and rabbits treated with ulinastatin (U group). After blood withdrawal, hemodynamic disturbance appeared in both groups. But the catecholamine concentration showed no increase in either groups. Significant differences between the groups were found only in urinary output and microcirculation. These were well maintained during hemorrhage in the ulinastatin treated group. It is concluded that ulinastatin is effective in maintaining microcirculation during excessive hemorrhage and fluid therapy.
Notoya
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Department of Anesthesiology, Tokyo Women's Medical College.
D000818:Animals; D006023:Glycoproteins / Q000494:pharmacology* / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects*; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000503:physiopathology
D006023:Glycoproteins; C028665:urinastatin