Localized proton NMR spectroscopy of brain tumors using short-echo time STEAM sequences.
Recent progress in localized proton NMR spectroscopy has been utilized to improve the spatial resolution and the metabolic specificity in a study of 19 patients with intracranial tumors. Selected examples demonstrate that short echo time stimulated echo acquisition mode sequences are able (a) to account for macroscopic tissue heterogeneity by reducing the volume of interest to 2-8 ml and (b) to facilitate a reasonable characterization of tumor metabolism by increasing the number of accessible metabolites. Proton NMR spectra were acquired within measuring times of 6.5 min on a 2.0 T whole-body system using the imaging headcoil.
Frahm
J
J
Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany.
Bruhn
H
H
Hänicke
W
W
Merboldt
K D
KD
Mursch
K
K
Markakis
E
E
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001254:Astrocytoma / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism* / Q000556:secondary; D004806:Ependymoma / Q000378:metabolism; D005260:Female; D005910:Glioma / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged
D007773:Lactates; D001224:Aspartic Acid; C000179:N-acetylaspartate; D005947:Glucose