In vivo effect of a large amount of allogeneic granulocytes on reconstitution of hemopoietic cells of irradiated mice.
The in vivo effects of allogeneic granulocytes on the reconstitution of splenic and bone marrow CFUs and CFUc numbers were investigated using irradiated mice. When allogeneic granulocytes were intraperitoneally injected into irradiated BDF1 mice (260 rads), the reconstitution of CFUs in both spleen and bone marrow as well as the hematocrit were enhanced, while the reconstitution of splenic or bone marrow CFUc numbers was transiently suppressed and then enhanced. The magnitude of enhancement was dose-dependent. These results suggest that granulocytes injected into irradiated mice might act as enhancing effectors on the in vivo reconstitution of hemopoietic cells.
First Department of Internal Medicine, Faculty of Medicine, Nihon University, Tokyo, Japan.
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I
Tsuboi
K
K
Morimoto
A
A
Sakuma
T
T
Horie
H
H
Sakoda
K J
KJ
Mori
D000818:Animals; D016913:Blood Component Transfusion; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D005260:Female; D006098:Granulocytes / Q000637:transplantation*; D006400:Hematocrit; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D007958:Leukocyte Count / Q000528:radiation effects; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology / Q000528:radiation effects; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation