A highly divergent simian immunodeficiency virus (SIVstm) recovered from stored stump-tailed macaque tissues.
We report here the results of molecular analysis of a simian immunodeficiency virus (designated SIVstm) which was isolated from a rhesus monkey inoculated with stored lymph node tissue of an Asian stump-tailed macaque. The latter monkey had died in 1977 during an epidemic of acquired immunodeficiency and lymphoma at the California Regional Primate Research Center (L. J. Lowenstine, N. W. Lerche, P. A. Marx, M. B. Gardner, and N. C. Pedersen, p. 174-176, in M. Girard and L. Valette, ed., Retroviruses of Human AIDS and Related Animal Viruses, 1988). Nucleotide sequence analysis of the gag and env regions indicates that SIVstm is an ancient member of the SIV/human immunodeficiency virus type 2 group; it is quite divergent from known SIVs isolated from African sooty mangabeys as well as from Asian macaques. Furthermore, of all SIV strains described to date, SIVstm is the most closely related to human immunodeficiency virus type 2.
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
A S
AS
Khan
T A
TA
Galvin
L J
LJ
Lowenstine
M B
MB
Jennings
M B
MB
Gardner
C E
CE
Buckler
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D015683:Gene Products, gag / Q000235:genetics; D015750:Genes, gag; D014644:Genetic Variation; D015498:HIV-2 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008198:Lymph Nodes / Q000382:microbiology; D008251:Macaca / Q000382:microbiology*; D008253:Macaca mulatta / Q000382:microbiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000302:isolation & purification
D015683:Gene Products, gag