Application of lectin histochemistry and carbohydrate analysis to the characterization of lysosomal storage diseases.
In lysosomal storage diseases that involve a defect in the catabolism of glycoconjugates, lectin histochemistry adds a new dimension to the characterization of stored carbohydrates as it identifies sugar residues in situ in the affected cells and, thus, determines which cell types are affected by storage. It may be combined with chemical and biochemical analysis by h.p.l.c. The present review summarizes recent results for a variety of storage diseases and presents new data for GM1-gangliosidosis.
Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111.
J
J
Alroy
R
R
De Gasperi
C D
CD
Warren
D000818:Animals; D050260:Carbohydrate Metabolism; D002240:Carbohydrate Sequence; D016537:Gangliosidosis, GM1 / Q000378:metabolism; D006001:Glycoconjugates / Q000737:chemistry / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D016464:Lysosomal Storage Diseases / Q000378:metabolism*; D008969:Molecular Sequence Data
D006001:Glycoconjugates; D037102:Lectins