[Does glycemic level influence the pharmacokinetics of an antibiotic (cefoperazone)?].
Hyperglycemia may modify pharmacokinetics of some antibiotics as shown in the literature. We studied the influence of glycaemic levels on pharmacokinetics properties of cefoperazone in 12 type 1 insulin dependent diabetic patients. Hyperglycaemia was obtained by a reduction of one quarter of their usual insulin dosage and normoglycaemia by an artificial pancreas (Biostator GCIIS). Cefoperazone had a high protein affinity and a high biliary elimination. Pharmacokinetic study was performed during a 8 hour period following one gram intravenous bolus. We did not found any influence of glycaemic level (normoglycaemia or hyperglycaemia) on the pharmacokinetic parameters of cefoperazone.
Gin
H
H
Clinique Médicale et des Maladies Infectieuses, Hôpital Pellegrin, Bordeaux, France.
Demotes-Mainard
F
F
Magimel
S
S
Albin
H
H
Morlat
P
P
Aubertin
J
J
D001786:Blood Glucose / Q000502:physiology*; D002438:Cefoperazone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology*; D007275:Injections, Intravenous; D007332:Insulin Infusion Systems; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D002438:Cefoperazone
Existe-t-il une influence du niveau glycémique sur la pharmacocinétique d'un antibiotique (la céforpérazone)?