Effects of amnion and live yeast cell derivative on second-intention healing in horses.
Equine amnion and live yeast cell derivative were evaluated as a biological dressing and as a topical wound medicament respectively, in the treatment of granulating wounds of the distal portion of the limbs of horses. Wounds measuring 2.5 x 2.5 cm were created on the dorsomedial aspect of the metacarpal and metatarsal region of all 4 limbs of 9 horses. Each wound was assigned randomly to 1 of 3 treatment groups: group C, treated with a nonadherent bandage as a control; group A, treated with amnion beneath a nonadherent bandage; and group L, treated with live yeast cell derivative beneath a nonadherent bandage. Rates of contraction and epithelialization were not significantly different among groups. Percentage of epithelialization for group A was significantly greater throughout the study than for the other groups. Number of days to complete healing was significantly less in group A and significantly greater in group L than in group C. Incidence and severity of exuberant granulation tissue were significantly less in group A than in the other 2 groups. Group L had more frequent and severe cases of exuberant granulation tissue than the other 2 groups.
Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, AL 36849-5522.
R B
RB
Bigbie
J
J
Schumacher
S F
SF
Swaim
R C
RC
Purohit
J C
JC
Wright
D000650:Amnion; D000818:Animals; D001684:Biological Dressings / Q000662:veterinary*; D001688:Biological Products; D004848:Epithelium / Q000502:physiology; D005260:Female; D006097:Granulation Tissue / Q000502:physiology; D006736:Horses / Q000293:injuries*; D008297:Male; D010446:Peptide Fragments; D010455:Peptides; D011897:Random Allocation; D012441:Saccharomyces cerevisiae; D014945:Wound Healing
D001688:Biological Products; D010446:Peptide Fragments; D010455:Peptides; C109694:live yeast cell derivative