Can high-dose immunoglobulin therapy be indicated in neonatal rhesus haemolysis? A successful case of haemolytic disease due to rhesus (c + E) incompatibility.
A male neonate with hyperbilirubinaemia and progressing anaemia due to rhesus (c + E) incompatibility received high dose intravenous gammaglobulin (ivIgG) therapy at 13 days of age. Clinical response to therapy was confirmed by a rapid decrease in serum bilirubin level, and with the prevention of a further decline of the haemoglobin level. No side-effects were noted. High dose ivIgG therapy could be an alternative to (exchange) blood transfusion in case of some haemolytic diseases of newborn.
Kubo
S
S
Department of Paediatrics, Hokkaido Central Hospital for Social Health Insurance, Sapporo, Japan.
Ariga
T
T
Tsuneta
H
H
Ishii
T
T
D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000627:therapeutic use; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage* / Q000627:therapeutic use; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D012203:Rh Isoimmunization / Q000628:therapy*
D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous