Susceptibility of different strains of mice to South American rattlesnake (Crotalus durissus terrificus) venom: correlation between lethal effect and creatine kinase release.
In the present work we report that susceptibility to Crotalus durissus terrificus venom: varies according to the strain of inbred mouse used. The s.c. LD50 for Balb/c and C57BI/6 mice were 193 micrograms/kg and 171 micrograms/kg, whereas for A/J and DBA/J they were 78 micrograms/kg and 74 micrograms/kg, respectively. In addition, a direct correlation between susceptibility to C. d. terrificus venom and creatine kinase serum levels (CK) was observed.
Departamento de Immunologia, Universidade de São Paulo, Brazil.
M R
MR
Lima
M C
MC
dos Santos
D V
DV
Tambourgi
T
T
Marques
W D
WD
da Silva
T
T
Kipnis
D000818:Animals; D003402:Creatine Kinase / Q000097:blood*; D003435:Crotalid Venoms / Q000633:toxicity*; D007700:Kinetics; D007928:Lethal Dose 50; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013045:Species Specificity
D003435:Crotalid Venoms; D003402:Creatine Kinase