Spectrophotometric prediction of the dissolution rate of carbamazepine tablets.
A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r2 = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.
Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky Medical Center, Lexington 40536-0082.
P N
PN
Zannikos
W I
WI
Li
J K
JK
Drennen
R A
RA
Lodder
D002220:Carbamazepine / Q000737:chemistry*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D013607:Tablets; D002220:Carbamazepine