Caenorhabditis elegans: a model system for space biology studies.
The utility of the nematode Caenorhabditis elegans in studies spanning aspects of development, aging, and radiobiology is reviewed. These topics are interrelated via cellular and DNA repair processes especially in the context of oxidative stress and free-radical metabolism. The relevance of these research topics to problems in space biology is discussed and properties of the space environment are outlined. Exposure to the space-flight environment can induce rapid changes in living systems that are similar to changes occurring during aging; manipulation of these environmental parameters may represent an experimental strategy for studies of development and senscence. The current and future opportunities for such space-flight experimentation are presented.
Johnson
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Department of Psychology, University of Colorado, Boulder 80309.
Nelson
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D000375:Aging; D000818:Animals; D002107:Caenorhabditis / Q000235:genetics / Q000502:physiology* / Q000528:radiation effects; D004260:DNA Repair / Q000528:radiation effects; D008954:Models, Biological; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects