Absence of association of HTLV-I infection with type 1 neurofibromatosis in the United States or Japan.
An HTLV-I tax transgenic mouse model develops a syndrome with similarities to type 1 neurofibromatosis (NF-1). To investigate possible associations between this human retrovirus and NF-1, we have analyzed 67 neurofibromas from Japan (where HTLV-I infection is endemic) and compared them with 21 cases from the United States. We were not able to identify virus in tumor tissue in either group. This suggests that HTLV-I infection is not commonly associated with NF-1.
Department of Neuropharmacology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.
M I
MI
Nerenberg
T
T
Minor
K
K
Nagashima
K
K
Takebayashi
K
K
Akai
C A
CA
Wiley
V M
VM
Riccardi
D000595:Amino Acid Sequence; D004279:DNA, Viral / Q000032:analysis; D015490:HTLV-I Infections / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008969:Molecular Sequence Data; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D016133:Polymerase Chain Reaction; D014481:United States / Q000453:epidemiology
D004279:DNA, Viral