[Plasma PAI-1 levels in patients with various tumors with or without metastasis].
Recently, much interest has focussed on fibrinolysis in malignant tumors. In our previous study, we showed that t-PA antigen was significantly increased in plasma from patients with malignant tumors with metastasis. In our present study, we measured plasminogen activator inhibitor-1 (PAI-1) levels in plasmas from patients with various tumors. PAI-1 antigen was measured by means of enzyme immuno assay in plasma from 64 consecutive patients with a variety of malignant tumors. Patients were subdivided into two groups, one with (n = 47) and without (n = 17) metastasis. In the group with metastasis except for lung cancer, PAI-1 antigen level was increased compared to age-matched control subjects, while in the group without metastasis, PAI-1 antigen level was normal.
Department of Clinical Pathology, Kobe City General Hospital.
Y
Y
Maeda
M
M
Souma
S
S
Kasakura
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000097:blood* / Q000473:pathology; D015849:Plasminogen Inactivators / Q000097:blood*
D015849:Plasminogen Inactivators