[Factor XIa-alpha 1 antitrypsin complex].
We developed a new rapid assay for the factor XIa-alpha 1 antitrypsin complex (FXIa-alpha 1AT) in plasma using an anti FXI monoclonal antibody (KMXI-1). In 20-fold diluted plasma samples, this assay was not affected by co-existing FXI or non specific color development of the plasma. Normal level of FXIa-alpha 1AT (11 +/- 4.1 ng/ml plasma) increased with the aging of healthy adults. The FXIa-alpha 1AT levels of patients with disseminated intravascular coagulation (DIC) rose along with the progression of the disease, and the appearance of high levels and the peak of FXIa-alpha 1AT developed faster than FDP-E or alpha 2plasmin inhibitor-plasmin complex (alpha 2PI-PmC) in most patients. These results indicate that, in addition of FDP and alpha 2PI-PmC, FXIa-alpha 1AT is a useful molecular marker for DIC.
Egawa
H
H
Department of Clinico-Laboratory Medicine, Kansai Medical University, Moriguchi.
Komiyama
Y
Y
Nishikado
H
H
Masuda
M
M
Murakami
T
T
Murata
K
K
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood; D000818:Animals; D015415:Biomarkers / Q000097:blood; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D015945:Factor XIa / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D012016:Reference Values; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D015415:Biomarkers; D000515:alpha 1-Antitrypsin; D015945:Factor XIa