Localized hyperkeratosis lenticularis perstans (Flegel's disease).
A case of hyperkeratosis lenticularis perstans involving only the back of a thirty-nine-year-old woman is reported. Histologic examination showed foci of compact and eosinophilic hyperkeratosis overlying a thinned stratum malpighii. In the underlying papillary dermis there was no evidence of inflammatory infiltrate. This case demonstrates that hyperkeratosis lenticularis perstans may appear as a localized disorder, and that the inflammation is not an essential pathogenic process in this disorder.
Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
M C
MC
Gutiérrez
A
A
Hasson
M D
MD
Arias
L
L
Martín
A
A
Barat
L
L
Requena
A
A
de Castro
D000328:Adult; D005260:Female; D006801:Humans; D007642:Keratosis / Q000473:pathology*; D012867:Skin / Q000473:pathology