Effects of the penetration of a root canal filling material into the mandibular canal. 1. Tissue reaction to the material.
The root canal filling paste Vitapex (Neo Dental Chemical Products Co., Tokyo), made of calcium hydroxide and iodoform with the addition of silicone oil, was experimentally introduced into the mandibular canals of 29 dogs. Tissue reactions to the paste were examined by radiography, histopathology, and electron microscopy. These examinations revealed that the paste was phagocytosed by macrophages and, in general, was gradually resorbed over time. The paste was also found to cause heterotopic calcification and/or ossification within the area of original penetration.
Department of Oral Pathology, Matsumoto Dental College, Shiojiri, Japan.
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Kawakami
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Nakamura
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Eda
D000818:Animals; D002114:Calcinosis / Q000139:chemically induced; D002126:Calcium Hydroxide / Q000633:toxicity*; D004285:Dogs; D004338:Drug Combinations; D008334:Mandible / Q000187:drug effects* / Q000648:ultrastructure; D009999:Ossification, Heterotopic / Q000139:chemically induced; D012387:Root Canal Filling Materials / Q000633:toxicity*; D012389:Root Canal Obturation / Q000009:adverse effects; D012828:Silicones / Q000633:toxicity*
D004338:Drug Combinations; D012387:Root Canal Filling Materials; D012828:Silicones; C029584:calcium hydroxide, iodoform, silicone oil drug combination; D002126:Calcium Hydroxide