Catecholamine and acetylcholine in the rat cerebral cortex with special reference to pathogenetic mechanisms of Alzheimer's disease.
A direct synapse between catecholamine fibers and neuropeptide Y-containing neurons is demonstrated in rat cerebral cortex using an immunohistochemical double-staining method under the electron microscope. A new method to produce a selective reduction in cholinergic neurons in the basal forebrain without damage to the non-cholinergic neurons, passing fibers or other cholinergic systems, is described. This animal model seems to be very useful to analyze the pathogenesis of Alzheimer's disease and to examine the function of cholinergic neurons of the basal forebrain.
Department of Neuroanatomy, Osaka University Medical School, Japan.
S
S
Shiosaka
M
M
Yamano
M
M
Tsuchiyama
Y
Y
Kudo
K
K
Imaizumi
M
M
Tohyama
D000109:Acetylcholine / Q000378:metabolism*; D000544:Alzheimer Disease / Q000209:etiology* / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D004195:Disease Models, Animal; D009474:Neurons / Q000378:metabolism; D009478:Neuropeptide Y / Q000378:metabolism; D051381:Rats
D002395:Catecholamines; D009478:Neuropeptide Y; D000109:Acetylcholine