The use of the Nb rat in combination chemotherapeutic experiments for prostate cancer.
The Nb rat adenocarcinoma model has been used to evaluate combination chemotherapy. The Nb rat is a model system in which one can measure tumor regression, tumor metastasis and response to treatment. Combination treatment decreased metastasis and increased the incidence of regression in this triple chemo treatment program of 5-FU, Adriamycin and Cisplatinum.
Drago
J R
JR
Department of Surgery, Ohio State University, Columbus.
Smith
J
J
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage; D004354:Drug Screening Assays, Antitumor; D005472:Fluorouracil / Q000008:administration & dosage; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D004317:Doxorubicin; D002945:Cisplatin; D005472:Fluorouracil