Changes of soluble interleukin-2, interleukin-2 receptor, T8 antigen, and interleukin-1 in the serum of autistic children.
Immune abnormalities in autistic children led us to study for indirect evidence of immune activation as measured by the serum analysis of soluble interleukin-2 (sIL-2), interleukin-2 receptor (sIL-2R), T8 antigen (sT8), and interleukin-1 (sIL-1). The serum concentration of these soluble antigens was quantitated by enzyme-linked immunosorbent assays. The concentration of sIL-2 and sT8, but not of sIL-2R and sIL-1, antigens was significantly (P less than 0.05) increased in the sera of autistic children over that in the control healthy children or children with mental retardation (non-Down's syndrome). This finding indirectly indicates that the activation of a subpopulation of T cells occurs in some children with autism.
Singh
V K
VK
Neuroimmunology Laboratory, Utah State University, Logan 84322-6800.
Warren
R P
RP
Odell
J D
JD
Cole
P
P
D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001321:Autistic Disorder / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012995:Solubility
D000945:Antigens, Differentiation, T-Lymphocyte; D007375:Interleukin-1; D007376:Interleukin-2; D015375:Receptors, Interleukin-2