Antiinflammatory evaluation of a Pluchea indica root extract.
A methanolic fraction of a chloroform extract of defatted Pluchea indica roots was investigated for its antiinflammatory potential against several models of inflammation. The extract showed significant inhibitory activity against carrageenin-, histamine-, serotonin-, hyaluronidase- and sodium urate-induced pedal inflammation. The extract inhibited protein exudation and leucocyte migration. The extract also inhibited carrageenin- and cotton pellet-induced granuloma formation as well as turpentine-induced joint oedema and adjuvant-induced polyarthritis. The present observations establish the efficacy of the extract in the exudative, proliferative and chronic stages of inflammation.
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
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Sen
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Nag Chaudhuri
D000315:Adrenalectomy; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000517:prevention & control; D002351:Carrageenan; D002464:Cell Migration Inhibition; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005122:Exudates and Transudates / Q000502:physiology; D003368:Gossypium; D006099:Granuloma / Q000139:chemically induced / Q000517:prevention & control; D006632:Histamine; D006821:Hyaluronoglucosaminidase; D007194:India; D051379:Mice; D010653:Phenylbutazone / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010998:Pleurisy / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D012701:Serotonin; D014425:Turpentine; D014527:Uric Acid
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D014527:Uric Acid; D012701:Serotonin; D006632:Histamine; D002351:Carrageenan; D006821:Hyaluronoglucosaminidase; D010653:Phenylbutazone; D014425:Turpentine