[The effect of trofopar, AICA phosphate and Essentiale on the detoxifying function and blood circulation of the liver in lesions in man].
The comparative clinicopharmacological studies established the ability of hepatotropic agents with the membrane stabilizing properties and metabolic activity--trophopar, aika-phosphate and essential to stimulate to various degrees the processes of microsomal oxidation of antipyrine in hepatocytes at their insufficiency in patients with lesions of the hepatobiliary system of the alcohol and viral etiology. The studied drugs improve also the condition of the intrahepatic hemodynamics according to the findings of rheohepatography. The correlations between the positive dynamics of the values of antipyrine clearance, the degree of arterial blood filling (the rheographic index) and the increase of serum albumin content were found that confirms the ability of trophopar, aika-phosphate and essential to exert the complex influence on the systems and mechanisms of the realization of the liver antitoxic function.
Nikolaeva
A P
AP
Loginov
A S
AS
Bendikov
E A
EA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008102:Liver Circulation / Q000187:drug effects* / Q000502:physiology; D008107:Liver Diseases / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D010713:Phosphatidylcholines / Q000627:therapeutic use*
D010455:Peptides; D010713:Phosphatidylcholines; C011246:essential 303 forte; D000620:Aminoimidazole Carboxamide; C028212:aminoimidazole carboxamide phosphate; C071168:trofopar
Vliianie trofopara, aĭka-fosfata i éssentsiale na detoksitsiruiushchuiu funktsiiu i krovoobrashchenie pecheni pri ee porazheniiakh u cheloveka.