Infectious entry pathway of adenovirus type 2.
Internalization of the infectious fraction of human adenovirus type 2 into HeLa cells was followed by a quantitative internalization assay. Treatments known to selectively block receptor-mediated endocytosis reduced the internalization of infectious virus to an extent close to the reduction of endocytosis of transferrin. This suggests that one of the first steps in the infectious cycle of adenovirus type 2 is internalization by the coated-pit and -vesicle pathway.
Department of Microbiology, University of Lund, Sweden.
M J
MJ
Varga
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C
Weibull
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Everitt
D000260:Adenoviruses, Human / Q000502:physiology* / Q000648:ultrastructure; D000643:Ammonium Chloride / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003034:Coated Pits, Cell-Membrane / Q000502:physiology*; D004705:Endocytosis / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006982:Hypertonic Solutions; D007700:Kinetics; D008854:Microscopy, Electron; D011991:Receptors, Virus / Q000502:physiology; D013395:Sucrose / Q000378:metabolism; D014771:Virion / Q000502:physiology*
D006982:Hypertonic Solutions; D011991:Receptors, Virus; D000643:Ammonium Chloride; D013395:Sucrose