Primary antiphospholipid syndrome: a report of two pediatric cases.
Two cases of primary antiphospholipid syndrome are described. A girl presented with myocardial infarction at the age of 6. afterward developed chorea, livedo reticularis, thrombocytopenia and circulating lupus anticoagulant (LAC). A boy, age 7, had an episode of intracranial hypertension and a deep venous thrombosis of a lower left limb, both recurrent in the following years. A high titer of IgG anticardiolipin antibodies (aCI) was detected. These observations suggest that both LAC and aCI tests should be performed in children with thromboembolic phenomena when the criteria for a definite autoimmune disease are lacking.
Department of Paediatrics, University of Florence, Italy.
F
F
Falcini
G
G
Taccetti
S
S
Trapani
L
L
Tafi
S
S
Petralli
M
M
Matucci-Cerinic
D000906:Antibodies / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis; D002308:Cardiolipins / Q000276:immunology; D002648:Child; D003392:Cranial Sinuses; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply; D016682:Lupus Coagulation Inhibitor / Q000032:analysis; D008297:Male; D009203:Myocardial Infarction / Q000150:complications; D013924:Thrombophlebitis / Q000150:complications
D000906:Antibodies; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor