Altered lymphocyte populations in sphha/sphha mice with chronic hemolytic anemia.
Lymphocyte kinetics and phenotype were examined in mutant anemic sphha/sphha mice that manifest a lifelong lymphocytosis which accompanies their chronic hemolytic anemia. Anemic mice have significant increases in CD4+, CD8+, and sIgM+ lymphocytes in peripheral blood. Pulse and continuous infusion studies with [3H]TdR suggest that this apparent lymphoid expansion is not due to increased production of lymphocytes in bone marrow or thymus but rather to a redistribution of lymphocytes from the spleen to other peripheral lymphoid tissue sites as well as increased proliferation of T and B lymphocytes in lymph nodes. This murine model could be useful to examine lymphocyte perturbations that may accompany chronic hemolytic anemia in humans.
Maggio-Price
L
L
Department of Comparative Medicine, University of Washington, Seattle 98195.
Grossmann
A
A
Engel
D
D
Rosse
C
C
D000745:Anemia, Hemolytic, Congenital / Q000276:immunology*; D000818:Animals; D001854:Bone Marrow Cells; D002455:Cell Division; D002908:Chronic Disease; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000276:immunology; D016131:Lymphocyte Subsets / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D010641:Phenotype; D013049:Spectrin / Q000235:genetics*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000502:physiology
D013049:Spectrin