Prognosis for seizure control and remission in children with myelomeningocele.
A combined retrospective and prospective study was designed to determine the incidence of seizures in 140 children with myelomeningocele, as well as the potential for seizure control and remission. The incidence of seizures in 109 patients with myelomeningocele and hydrocephalus was 16.5 per cent, and 19.4 per cent in a further 31 patients without hydrocephalus. Mental retardation, often in combination with cerebral malformations, was significantly more common in children with seizures, regardless of presence or absence of hydrocephalus. Of the 24 patients with convulsion, three-quarters had anti-epileptic medication discontinued, without recurrence of seizures. An additional five children's seizures are well controlled with medication. Mental retardation was the only significant predictor of long-term outcome. These results indicate that children with myelomeningocele have an excellent prognosis for seizure control and subsequent remission off medication.
Edward Mallinckrodt, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110.
M J
MJ
Noetzel
J N
JN
Blake
D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D001921:Brain / Q000002:abnormalities / Q000187:drug effects / Q000503:physiopathology; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008591:Meningomyelocele / Q000503:physiopathology*; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology
D000927:Anticonvulsants