[The observation of changes in plasma PGI2 and TXA2 levels and the therapeutic effect of tetramethylpyrazine in E. coli induced acute lung injury in rabbits].
Thirty two rabbits were equally divided at random into 4 groups: A. control; B. E.coli; C. E.coli + ibuprofen; D. E.coli + tetramethylpyrazine. The plasma concentration of 6-keto-PGF1 alpha and TXB2, arterial blood gas as well as platelet aggregability were measured and the pathological changes of lung tissue were observed. The results suggest that TXA2 and PGI2 do take part in the pathogenesis of acute lung injury; that PGI2 may serve as an indicator in the evaluation of the degree of injury in the pulmonary endothelial cells and may also contribute to septic shock; and that both tetramethylpyrazine and ibuprofen possess therapeutic effects on the amelioration of acute lung injury, and the former is rather stronger than the latter in the inhibitory effect on granulocytic sequestration within the lung.
Li
B
B
First Hospital of Beijing Medical University.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000818:Animals; D004927:Escherichia coli Infections / Q000097:blood* / Q000188:drug therapy; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000097:blood* / Q000188:drug therapy; D008297:Male; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011719:Pyrazines / Q000627:therapeutic use*; D011817:Rabbits; D013929:Thromboxane B2 / Q000097:blood*
D010975:Platelet Aggregation Inhibitors; D011719:Pyrazines; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C017953:tetramethylpyrazine