Persistence of parvovirus B19-DNA in blood of a child with severe combined immunodeficiency associated with chronic pure red cell aplasia.
In a female child with severe combined immunodeficiency, pure red cell aplasia was observed which required regular transfusions of erythrocytes. Parvovirus B 19 DNA (but no antibodies) was detected in stored serum samples after the death of the patient. We suggest that the anaemia was a consequence of parvovirus infection which persisted for at least 2 years due to the immunodeficiency.
Universitäts-Kinderklinik Göttingen, Federal Republic of Germany.
M
M
Gahr
A
A
Pekrun
H
H
Eiffert
D002908:Chronic Disease; D004279:DNA, Viral / Q000097:blood*; D016731:Erythema Infectiosum / Q000150:complications*; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000150:complications*; D007223:Infant; D016732:Parvovirus B19, Human / Q000235:genetics*; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000209:etiology*
D004279:DNA, Viral