Toxicity of litholytic ethylenediaminetetraacetic acid solutions to the urothelium of the rat and dog.
The toxicity to the urothelium of bipotassium ethylene-diaminetetraacetic acid (K2-EDTA) buffered with 0.2 M triethanolamine (TEA) at pH 8 and 8.5 was tested in rats and dogs. Even at a low concentration of 3.125 mM, K2-EDTA is very noxious to the bladder mucosa. This toxicity is not due to the buffer TEA, which is well tolerated. Although buffered K2-EDTA, at pH 8.5 is an excellent chemolytic agent for calcium-containing stones, its clinical use is limited by this toxicity.
Department of Urology, State University, Ghent, Belgium.
W
W
Oosterlinck
R
R
Verbeeck
C
C
Cuvelier
H
H
Verplaetse
A
A
Verbaeys
D000818:Animals; D002021:Buffers; D004285:Dogs; D004492:Edetic Acid / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects; D004983:Ethanolamines; D005260:Female; D007669:Kidney Calculi / Q000628:therapy; D009092:Mucous Membrane / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000187:drug effects*
D002021:Buffers; D004983:Ethanolamines; D004492:Edetic Acid; C009546:triethanolamine