High urinary dopa and low urinary dopamine-to-dopa ratio in salt-sensitive hypertension.
Dopamine in urine is derived substantially from renal uptake and decarboxylation of 3,4-dihydroxyphenylalanine (dopa), and increases in excretion of dopa normally parallel increases in excretion of dopamine during salt loading. Since patients with salt-sensitive hypertension may have decreased urinary excretion of dopamine during dietary salt loading, the present study was designed to evaluate the response of dopa to salt loading. Sixteen inpatients with normal-renin essential hypertension ate a constant metabolic diet containing 9 mmol/day sodium for 7 days, followed by the same diet but containing 249 mmol/day sodium for 7 days. Salt sensitivity was defined as an increase in mean arterial pressure of 8 mm Hg between the diets; on this basis, nine patients were salt-sensitive and seven, salt-resistant. The rate of urinary dopa excretion was significantly higher in the salt-sensitive patients throughout the study (mean rates 132 +/- 13 nmol/day in the salt-sensitive group and 78 +/- 9 nmol/day in the salt-resistant group for the 14 days of observation, p less than 0.01). When dietary sodium intake was increased to 249 mmol/day, urinary dopa excretion increased significantly more in salt-sensitive patients than salt-resistant patients. At the end of the high salt diet, dopamine excretion was significantly attenuated in the salt-sensitive patients, despite higher rates of dopa excretion. Thus, the urinary ratio of dopamine to dopa was decreased in salt-sensitive patients, regardless of salt intake.(ABSTRACT TRUNCATED AT 250 WORDS)
Gill
J R
JR
Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, Bethesda, Md 20892.
Grossman
E
E
Goldstein
D S
DS
D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D004295:Dihydroxyphenylalanine / Q000652:urine*; D004298:Dopamine / Q000652:urine*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride; D004295:Dihydroxyphenylalanine; D012964:Sodium; D004298:Dopamine; D009638:Norepinephrine