[The role of the autonomic nervous system in regulating bone marrow erythropoiesis in stress].
Injection of one of the pharmacological neurotropic antagonists (neuroleptic, ganglionic blocking, alpha- or beta-adrenergic blocking agents) abolished the phenomenon of erythropoiesis activation in immobilization stress in mice. Blockade of alpha- and beta-adrenergic receptors significantly reduced the number of erythroid colonies forming from cells of bone marrow culture in vitro and the erythropoietin level in blood serum and supernatants of bone marrow cells. The M-cholinergic blocking agent had no effect on the bone marrow erythrokaryocyte content in immobilized animals. At the same time, stimulation of alpha- and beta-adrenergic receptors led to a dose-dependent increase of the number of erythroid cells in the bone marrow of mice exposed to the effect of immobilization.
A M
AM
Dygaĭ
I A
IA
Khlusov
V P
VP
Shakhov
E D
ED
Gol'dberg
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology*; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004906:Erythrocyte Count / Q000187:drug effects; D004920:Erythropoiesis / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*
Rol' vegetativnoĭ nervnoĭ sistemy v reguliatsii kostnomozgovogo éritropoéza pri stresse.