Role of immunotherapy in the treatment of bladder and renal cell carcinoma.
Much remains to be learned about the immune response in human neoplasia both in a phenomenological sense and in its therapeutic possibilities. Recruitment of immune response mechanisms in the defense against cancer development and in the cure of advanced disease, though theoretically sound, remains to be proven in demonstration of both its phenomenological and clinical efficacy. The most important steps in this regard will require an analysis of those mechanisms that may truly be active in human cancer. Their enhancement and effective delivery to various tumor sites, then reliable monitoring, and proof of their efficacy will be necessary to accomplish before any conclusive statement can be made as to the usefulness of immunotherapy in the treatment of genitourinary neoplasia and of human cancer in general.
Stone
N N
NN
Department of Urology, Mount Sinai Medical Center, New York, NY 10029.
Droller
M J
MJ
D000951:Antigens, Neoplasm / Q000502:physiology; D002292:Carcinoma, Renal Cell / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D007680:Kidney Neoplasms / Q000276:immunology / Q000628:therapy*; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000628:therapy*
D000951:Antigens, Neoplasm