[Toxicological effect of a fatty acid mixture in rats].
The effects of a fatty acids mixture containing nearly 50% odd numbered fatty acids (PC-Säure) were studied in a subchronic toxicity test in male and female rats. The animals received PC-Säure in their diet at levels of 0, 1.25, 2.5 and 5% for 13 weeks. Food intake was increased at 5% PC-Säure level in males. Food efficiency was initially decreased in males and females of this group. Ingestion of PC-Säure resulted in increases of the urine volume and the urinary lactate dehydrogenase activity in both sexes. Male and female rats fed PC-Säure showed elevated serum activities of alkaline phosphatase and leucine aminopeptidase and decreases in serum cholesterol and triglycerides. Dietary PC-Säure elevated the serum creatinine content in males at the two highest levels. A transitory increase in the activity of the serum alanine aminotransferase was observed in females fed 5% PC-Säure. Increased liver and kidney weights were found in both sexes.
Zentralinstitut für Ernährung in Potsdam-Rehbrücke, Bundesrepublik Deutschland.
H J
HJ
Lewerenz
D W
DW
Bleyl
B
B
Ozierenski
R
R
Plass
R
R
Macholz
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004435:Eating / Q000187:drug effects; D005227:Fatty Acids / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000652:urine; D007931:Leucyl Aminopeptidase / Q000097:blood; D008099:Liver / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D014280:Triglycerides / Q000097:blood; D014556:Urine
D005227:Fatty Acids; D014280:Triglycerides; D002784:Cholesterol; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase
Toxikologische Wirkungen eines Fettsäuregemisches bei Ratten.