Paradoxical lid elevation with sustained upgaze: a sign of Lambert-Eaton syndrome.
Myasthenia gravis and Lambert-Eaton myasthenic syndrome are causes of acquired extraocular muscle weakness and ptosis. Exacerbation of ptosis after sustained upgaze is a clinically useful sign in the diagnosis of myasthenia gravis. A 54-year-old woman with established Lambert-Eaton myasthenic syndrome exhibited transient improvement of her ptosis after sustained upgaze. We suggest that paradoxical lid elevation after sustained upgaze may be a clinically useful sign in distinguishing Lambert-Eaton myasthenic syndrome from myasthenia gravis.
Department of Neurology, West Virginia University School of Medicine, Morgantown.
L A
LA
Breen
L
L
Gutmann
J F
JF
Brick
J R
JR
Riggs
D001763:Blepharoptosis / Q000209:etiology* / Q000503:physiopathology; D003937:Diagnosis, Differential; D004594:Electrophysiology; D005133:Eye Movements / Q000502:physiology; D005143:Eyelids / Q000503:physiopathology; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000175:diagnosis