Expression of lymphocyte homing receptor gene is lost in multi-drug-resistant variants of human T-lymphoblastoid CCRF-CEM cells.
The 2.2-kb human cDNA clone PBL32, encoding for the lymphocyte homing receptor (LHR) was used to study the expression of this determinant in multi-drug-resistant (MDR) variants of human T-lymphoblastoid CCRF-CEM (CEM) cells. LHR is significantly associated with the drug-sensitive phenotype, its expression being progressively and quantitatively reduced in MDR variants of CEM cells according to the extent of drug resistance.
Laboratorio di Immunologia, Istituto Superiore di Sanità, Rome, Italy.
M
M
Cianfriglia
A
A
Yassen
M
M
Tombesi
P
P
Samoggia
S
S
Barca
M
M
Caserta
D004351:Drug Resistance / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D012333:RNA, Messenger / Q000032:analysis*; D016201:Receptors, Lymphocyte Homing / Q000235:genetics*; D014407:Tumor Cells, Cultured
D012333:RNA, Messenger; D016201:Receptors, Lymphocyte Homing