The effect of portal hypertension on indomethacin-induced small intestinal ulceration in the rat.
The purpose of this study was to determine whether portal hypertension potentiates intestinal ulceration induced by indomethacin. Portal hypertension was produced in male Sprague-Dawley rats by two-staged ligation of the portal vein. Sham-operated rats were used as controls. The rats were given 20 mg/kg of indomethacin intragastrically, 7 and 14 days, respectively, after complete portal vein ligation. Forty-eight and 72 h after indomethacin, portal pressures were measured and the whole small intestine removed for quantitative measurement of the percent of the mucosa ulcerated by computerized image analysis. There were no differences in the area of ulceration between the portal hypertensive and sham-operated rats at either 7 or 14 days, despite the presence of significant portal hypertension. Portal hypertension does not appear to potentiate small intestinal ulceration induced by indomethacin in rats.
Department of Medicine, Department of Veterans Affairs Medical Center, Long Beach, California 90822.
G M
GM
Jonas
R A
RA
Erickson
K
K
Chung
D000818:Animals; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D006975:Hypertension, Portal / Q000150:complications*; D007213:Indomethacin / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007213:Indomethacin