On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic acid.
Institut für Toxikologie und Embryopharmakologie der Freien Universität, Berlin, FRG.
R S
RS
Hauck
H
H
Nau
M M
MM
Elmazar
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use* / Q000633:toxicity; D015195:Drug Design; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use* / Q000633:toxicity; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use* / Q000633:toxicity; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D010433:Pentylenetetrazole; D011247:Pregnancy; D012044:Regression Analysis; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013237:Stereoisomerism; D013723:Teratogens / Q000633:toxicity*; D014635:Valproic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use* / Q000633:toxicity
D000927:Anticonvulsants; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D013723:Teratogens; C071194:2-n-propyl-4-pentynoic acid; C045022:2-propyl-4-pentenoic acid; D014635:Valproic Acid; D010433:Pentylenetetrazole