Effects of detomidine on equine oesophageal function as studied by contrast radiography.
The effects of sedation with detomidine on oesophageal function were assessed by contrast radiography in 10 healthy adult thoroughbred horses. Barium swallows were monitored by means of image intensification, first without sedation and then after the intravenous administration of detomidine at doses of 10 and 20 micrograms/kg bodyweight. The transit time of contrast agent to the oesophageal hiatus was recorded and each swallow was scored for markers of oesophageal dysfunction. Analysis of the data indicated that there were highly significant dose dependent increases in the transit time, the retention of barium within the longitudinal mucosal folds, and retrograde peristalsis and pooling of contrast agent within the oesophagus at both the thoracic inlet and caudal to the base of the heart. The degree of gastrooesophageal reflux was not affected at either dosage. These changes in oesophageal function were similar to those recorded from cases of grass sickness and indicate that care should be taken in the interpretation of studies of swallowing in animals that have been given detomidine before a radiographic examination.
Department of Veterinary Medicine, University of Glasgow Veterinary School, Bearsden.
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Sullivan
D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis / Q000662:veterinary*; D003937:Diagnosis, Differential; D004108:Dilatation, Pathologic / Q000139:chemically induced / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D004931:Esophageal Achalasia / Q000139:chemically induced / Q000662:veterinary; D004935:Esophageal Diseases / Q000139:chemically induced / Q000662:veterinary; D004947:Esophagus / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000139:chemically induced / Q000662:veterinary; D006734:Horse Diseases / Q000139:chemically induced / Q000175:diagnosis*; D006736:Horses / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000494:pharmacology*; D007093:Imidazoles / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D010528:Peristalsis / Q000187:drug effects; D011859:Radiography; D012984:Software
D006993:Hypnotics and Sedatives; D007093:Imidazoles; C041255:detomidine