[Ursodeoxycholic acid. Physical properties and hepatoprotective activity].
In patients with cystic fibrosis, obstruction of bile ductules by mucus plugs and hepatocellular retention of hydrophobic bile acids including chenodeoxycholic acid may induce cholestasis and biliary cirrhosis. Ursodeoxycholic acid is a hydrophilic bile acid whose physicochemical characteristics differ markedly from those of chenodeoxycholic acid. Critical micellar concentration is higher and surface activity lower with ursodeoxycholate, whose micelles induce less solubilization of lecithin and cholesterol. In animal models, ursodeoxycholate increases bile excretion and prevents cholestasis and cytolysis induced by hydrophobic bile salts. Taken together, these data suggest that ursodeoxycholate therapy may have a beneficial effect on cystic fibrosis-related hepatobiliary disorders.
Montet
J C
JC
INSERM, Marseille, France.
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002779:Cholestasis / Q000150:complications / Q000378:metabolism; D003550:Cystic Fibrosis / Q000150:complications; D006801:Humans; D051381:Rats; D014580:Ursodeoxycholic Acid / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
D001647:Bile Acids and Salts; D014580:Ursodeoxycholic Acid
L'acide ursodésoxycholique. Propriétés physiques et activité hépatoprotectrice.