Chronic administration of nicotine fails to alter the MPTP-induced neurotoxicity in mice.
1. The effects of chronic (14 day) administration of nicotine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (15 mg/kg, s.c.)-induced neurotoxicity in C57BL/6 mice were examined. 2. Nicotine pretreatment failed to alter the deficit in locomotor activity and the reduction in striatal levels of dopamine produced by MPTP. 3. Our results do not support a therapeutic action of nicotine in a Parkinsonian animal model.
Fung
Y K
YK
Department of Oral Biology, University of Nebraska Medical Center, College of Dentistry, Lincoln 68583-0740.
Fiske
L A
LA
Lau
Y S
YS
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D020267:MPTP Poisoning; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D009538:Nicotine / Q000008:administration & dosage*; D010300:Parkinson Disease / Q000188:drug therapy
D009538:Nicotine; D004298:Dopamine