Ectopic production of calciotropic peptides.
Tumors are frequently associated with factors that affect bone cell function and calcium homeostasis. As a result, many patients with cancer develop paraneoplastic syndromes. The commonest is hypercalcemia of malignancy. Other related paraneoplastic syndromes are hypocalcemia, hypophosphatemia, and osteomalacia.
Department of Medicine, University of Texas Health Science Center, San Antonio.
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Mundy
D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D002402:Cathepsin D / Q000502:physiology; D004792:Enzyme Precursors / Q000502:physiology; D006729:Hormones, Ectopic / Q000502:physiology*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000503:physiopathology; D006996:Hypocalcemia / Q000209:etiology / Q000503:physiopathology; D007375:Interleukin-1 / Q000502:physiology; D008233:Lymphotoxin-alpha / Q000502:physiology; D010018:Osteomalacia / Q000209:etiology; D009384:Paraneoplastic Endocrine Syndromes / Q000150:complications; D010281:Parathyroid Hormone / Q000502:physiology; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000502:physiology; D016211:Transforming Growth Factor alpha / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D004792:Enzyme Precursors; D006729:Hormones, Ectopic; D007375:Interleukin-1; D008233:Lymphotoxin-alpha; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D016211:Transforming Growth Factor alpha; D014409:Tumor Necrosis Factor-alpha; C058345:procathepsin D; D002402:Cathepsin D; D002118:Calcium