Multimodality exploration of event-related potentials in chronic alcoholics.
Short- and long-latency auditory evoked potentials (SAEPs and LAEPs), visual-evoked potentials (VEPs), and contingent negative variation (CNV) were studied in 32 chronic alcoholics and their age-, sex-, and education-matched control subjects. The alcoholics exhibited a delayed SAEP peak V and an increase in the III-V and I-V intervals, increased VEP P100 latency, increased LAEP N2 and P3 latencies and increased LAEP N1-P2 amplitude. The analysis of the anomalies at a clinical level indicates a differential sensitivity of the event-related potentials. The parameters most sensitive to chronic alcohol consumption were (in descending order) P3 latency, peak V latency, the I-V and III-V intervals, and P100 latency.
Department of Psychiatry and Clinical Psychobiology, Universitat de Barcelona, Spain.
F
F
Cadaveira
C
C
Grau
M
M
Roso
M
M
Sanchez-Turet
D000328:Adult; D000437:Alcoholism / Q000503:physiopathology*; D000704:Analysis of Variance; D003265:Contingent Negative Variation; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012680:Sensitivity and Specificity