[Successful use of isotretinoin in type Zumbusch generalized pustular psoriasis following recovered etretinate-induced hepatitis].
Administration of etretinate in a 29-year-old female patient suffering from severe pustular psoriasis caused a dramatic increase in liver enzymes. Liver biopsy revealed changes characteristic for drug-induced hepatitis. After normalization of liver parameters following withdrawal of etretinate, isotretinoin was administered during a severe pustular relapse. In contrast to etretinate, isotretinoin was well tolerated and resulted in a good therapeutic response. Thus, isotretinoin can be considered as an effective and safe therapeutic alternative for pustular psoriasis even after the occurrence of etretinate-induced hepatitis.
Dermatologische Abteilung, Krankenhaus der Stadt Wien-Lainz.
I
I
Marhold
P
P
Duschet
T
T
Schwarz
F
F
Gschnait
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D005050:Etretinate / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D008111:Liver Function Tests; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology
D005050:Etretinate; D015474:Isotretinoin
Erfolgreicher Einsatz von Isotretinoin bei Psoriasis pustulosa generalisata Typ Zumbusch nach abgelaufener Etretinathepatitis.