Use of a marker of collagen formation in osteoporosis studies.
Type I collagen accounts for most of the organic matrix of bones, but it is also an important constituent of soft connective tissue. Assessment of the turnover of such collagen is particularly relevant to bone metabolism. Determination of the carboxyterminal propeptide of type I procollagen (PICP) is a means of estimating the rate of type I collagen synthesis in the body. Serum concentrations of PICP have been shown to correlate with the rate of bone formation.
Department of Medical Biochemistry, University of Oulu, Finland.
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Risteli
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J
Melkko
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Niemi
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Risteli
D000328:Adult; D015415:Biomarkers; D001826:Body Fluids / Q000378:metabolism; D001851:Bone Diseases, Metabolic / Q000097:blood; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000097:blood / Q000378:metabolism*; D010446:Peptide Fragments / Q000097:blood / Q000378:metabolism; D011347:Procollagen / Q000097:blood / Q000378:metabolism
D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C042813:procollagen type I carboxy terminal peptide; D003094:Collagen