[Etiology of multiple sclerosis].
The risk of developing Multiple Sclerosis is under the combined influence of environmental and endogenous factors, as shown by epidemiological and genetic studies. Immunological abnormalities are a salient feature of the disease but their myelinotoxic effect is still to be demonstrated. The pathogenesis of the disease remains unknown. The auto-immune theory as well as the infectious theory are arguable but they may, also, be both valid. Multiple sclerosis could be a post-infectious auto-immune disease, "final common way" of common childhood infections. Anyway, no infectious agent is demonstrable inside the central nervous system at the overt disease stage.
Clinique de neurologie, hôpital neurologique, Lyon.
C
C
Confavreux
B
B
Goudable
T
T
Moreau
D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D012307:Risk Factors
Etiologie de la sclérose en plaques.