[Structural and functional changes in the liver of pregnant rats and their fetuses exposed to cadmium, benzol and lead nitrate].
Lead nitrate administered to noninbred rats with drinking water on the level of IO MAC (0.3 mg/l) during the whole period of gestation lead to the strengthening of hepatotoxic effect of cadmium chloride (7.5 and 15 mg/kg daily by gavage from the 1st to 20th day of gestation), manifest in significant increase of the hepatocytes alteration index, increase of the number of the pyknotic cells of reticuloendothelial system, increase of the degree of dams' liver hepatocytes dystrophy, decrease in the specific volume of megakaryocytes in the liver of their fetuses.
Litvinov
N N
NN
Lamentova
T G
TG
Kazachkov
V I
VI
D000818:Animals; D001554:Benzene / Q000008:administration & dosage / Q000633:toxicity*; D002104:Cadmium / Q000008:administration & dosage / Q000633:toxicity*; D019256:Cadmium Chloride; D008058:Dihydrolipoamide Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D009566:Nitrates / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D014874:Water Pollutants, Chemical / Q000008:administration & dosage / Q000633:toxicity*
D009566:Nitrates; D014874:Water Pollutants, Chemical; D002104:Cadmium; D007854:Lead; C017461:lead nitrate; D007770:L-Lactate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D001554:Benzene; D019256:Cadmium Chloride
Strukturno-funktsional'nye izmeneniia v pecheni beremennykh krys i ikh plodov pri vozdeĭstvii kadmiia, benzola i nitrata svintsa.