Magnetic field elicits hypotension mediated by platelet activating factor in rats injected with iron beads.
Rats injected intravenously with iron beads (avg. diameter 3.4 microns; 1 g/kg body weight) were exposed to static or time-varying magnetic fields (400 gauss) for 5 min, which elicited a marked and rapid decrease in the mean arterial blood pressure (52 +/- 7 mmHg, mean +/- SE), lasting for 1-2 h. Hypotension was prevented or reverted by the platelet activating factor (PAF) antagonist SRI 63-675. The release of PAF from iron-loaded phagocytes may be due to magneto-orientational effects on membranes. This novel magnetic bioeffect can also be used for the study of PAF-mediated circulatory shock.
Mészáros
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Septic Shock Research Program, Naval Medical Research Institute, Bethesda, MD 20889.
D000818:Animals; D001794:Blood Pressure / Q000528:radiation effects; D004574:Electromagnetic Fields; D007022:Hypotension / Q000097:blood / Q000503:physiopathology*; D007501:Iron; D008297:Male; D008863:Microspheres; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D010972:Platelet Activating Factor; D011804:Quinolines; C053130:SRI 63-675; D007501:Iron