[Induction of unstable mutations in Drosophila melanogaster by microinjection of oncogenic virus DNA into polar embryonic plasm. Malignant effect of oncoviral DNA].
We have demonstrated that the ability to induce benign neoplasms We have dominant mode of inheritance in Drosophila melanogaster is the specific feature of oncoviral DNAs. It is supposed that development of this type of neoplasms in Drosophila is connected with the changes in expression of protooncogenes in mutant genome: firstly, the genetic factors directing the development of neoplasms and Drosophila protooncogenes which shared the homology with v-src are localised in the same regions; secondly, there are structural rearrangements in c-src/fps (29A) protooncogene in mutant stocks which display the ability for neoplastic growth.
Nabirochkin
S D
SD
Gabitova
L B
LB
Begetova
T V
TV
Gazarian
K G
KG
D000818:Animals; D015139:Blotting, Southern; D004279:DNA, Viral / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D005814:Genes, Viral; D008845:Microinjections; D009154:Mutation; D009374:Neoplasms, Experimental / Q000235:genetics; D009858:Oncogenic Viruses / Q000235:genetics*; D011519:Proto-Oncogenes
D004279:DNA, Viral
Induktsiia nestabil'nykh mutatsiĭ u Drosophila melanogaster mikroin''ektseĭ DNK onkogennykh virusov v poliarnuiu plazmu émbrionov. Maligniziruiushchiĭ éffekt onkovirusnykh DNK.