Intracytoplasmic lumina--a useful diagnostic feature of adenocarcinomas.
The monoclonal antibody NCRC-11, which has epithelial membrane antigen (EMA)-like immunoreactivity, was used to identify intracytoplasmic lumina in a series of 105 adenocarcinomas from various sites and in 283 breast carcinomas; 55% of the non-breast carcinomas and all breast carcinomas except one of spindle cell type contained intracytoplasmic lumina. The highest frequency (16.4% of tumour cells) was found in invasive lobular carcinoma of the breast. The use of antibodies with EMA reactivity is advocated in the routine investigation of metastatic and undifferentiated tumours.
Department of Histopathology, City Hospital, Nottingham, UK.
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C
Quincey
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Raitt
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Bell
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Ellis
D000230:Adenocarcinoma / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D003593:Cytoplasm / Q000276:immunology / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000276:immunology; D018396:Mucin-1
D000911:Antibodies, Monoclonal; D008562:Membrane Glycoproteins; D018396:Mucin-1