Virulence of rimantadine-resistant human influenza A (H3N2) viruses in ferrets.
The influence of rimantadine-resistance mutations on the virulence of human H3N2 viruses in ferrets was examined. The similarities in virulence of the drug-resistant mutants with single amino acid substitutions at three different locations, 27, 30, and 31, within the M2 sequence and their corresponding sensitive wild-type isolates contrasted with differences in virulence between the three pairs of viruses. These data provide further evidence that rimantadine-resistant viruses that emerge during treatment of patients with the drug are unaltered both in their growth characteristics and virulence.
Microbial Molecular Genetics and Cell Biology Research Group, University of Birmingham, United Kingdom.
C
C
Sweet
F G
FG
Hayden
K J
KJ
Jakeman
S
S
Grambas
A J
AJ
Hay
D000818:Animals; D004195:Disease Models, Animal; D004352:Drug Resistance, Microbial; D005289:Ferrets; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000187:drug effects / Q000472:pathogenicity* / Q000502:physiology; D008297:Male; D009976:Orthomyxoviridae Infections / Q000382:microbiology*; D012299:Rimantadine / Q000494:pharmacology*; D014774:Virulence; D014779:Virus Replication
D012299:Rimantadine