Effect of haemolysis on reticuloendothelial system (RES) phagocytic activity in rats.
The role of haemolysis of blood in the alterations in the uptake of [99mTc]SC ([99mTc]-sulphur colloid) in vivo in the rat has been examined. When the haemolysed blood (produced by first freezing the blood in liquid nitrogen) was infused into synergenic Lewis rats via the tail vein, there was a significant reduction in the uptake of the [99mTc]SC by the spleen, but lung, liver and kidney uptake remained constant. These results suggest that haemolysis of the blood may play a role in the alterations in RES phagocytic activity observed in the spleen following thermal injury.
Department of Pediatrics and Pediatric Gastroenterology, Massachusetts General Hospital, Shriners Burns Institute, Boston.
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Trop
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Schiffrin
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EA
Carter
D000818:Animals; D002056:Burns / Q000503:physiopathology*; D005260:Female; D006461:Hemolysis / Q000502:physiology*; D012157:Mononuclear Phagocyte System / Q000502:physiology; D010587:Phagocytosis; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000502:physiology; D013671:Technetium Tc 99m Sulfur Colloid
D013671:Technetium Tc 99m Sulfur Colloid