Antioxidant protection mechanism of chick hepatic mitochondria exposed to lanthanum chloride & neodymium chloride treatment.
Acute lanthanum chloride (250 mg/kg body wt) and neodymium chloride (200 mg/kg body wt) administrations resulted in significant enhancement of glutathione level in chick hepatic mitochondria. However, glutathione-s-transferase activity was depressed. There was no alteration in the activity of glutathione reductase. Activity of glucose-6-phosphate dehydrogenase was not altered under lanthanum and neodymium treatment. There was a significant enhancement of intramitochondrial glutathione peroxidase and superoxide dismutase. Lipid peroxidation remains the same as control group of animals.
Department of Biochemistry, University College of Science, Calcutta, India.
N
N
Ghosh
D
D
Chattopadhyay
G C
GC
Chatterjee
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002645:Chickens; D007811:Lanthanum / Q000494:pharmacology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009354:Neodymium / Q000494:pharmacology*
D000975:Antioxidants; C028521:lanthanum chloride; C053739:neodymium chloride; D009354:Neodymium; D007811:Lanthanum