Response of brain protein kinase C isozymes to ethyl oleate, an alcohol metabolite.
Rat brain protein kinase C (PKC) isozymes I, II and III were stimulated by fatty acids in the absence and presence of calcium. Ethyl oleate, which by itself has no effect on PKC activity, had a potentiating effect on fatty acid-induced activation of all 3 isozymes. Potentiation was observed predominantly in the presence of calcium. Interaction of ethyl oleate with a signalling mechanism involving PKC may underlie the cognitive disturbances noted after alcohol consumption.
Holian
O
O
Department of Surgery, College of Medicine, University of Illinois, Chicago 60612.
Ruiz
C
C
Kumar
R
R
Nyhus
L M
LM
D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D001921:Brain / Q000201:enzymology*; D002118:Calcium / Q000494:pharmacology; D004075:Diglycerides / Q000737:chemistry / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology; D007527:Isoenzymes / Q000378:metabolism*; D009829:Oleic Acids / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship
D004075:Diglycerides; D005227:Fatty Acids; D007527:Isoenzymes; D009829:Oleic Acids; D016718:Arachidonic Acid; D011493:Protein Kinase C; D002118:Calcium; C033180:ethyl oleate