Acute inhalation toxicity studies in several animal species of an ethylene oxide/propylene oxide copolymer (UCON 50-HB-5100).
An acute inhalation toxicity study in several species of animals with an ethylene oxide/propylene oxide copolymer (EO/PO) having a molecular weight of 4000 [UCON-50-HB-5100, CAS #9038-95-3] was designed to determine if any species variation could be shown. Species tested included: rats, mice, hamsters, guinea pigs, and dogs. The test material was administered as a respirable liquid aerosol for 4 hours at target concentrations of 50, 100, 200, and 500 mg/m3. A vehicle control group was exposed to a distilled water aerosol. The 4 hours LC50's were calculated to be 147 mg/m3 [rats], 174 mg/m3 [mice], 293 mg/m3 [guinea pigs] and 511 mg/m [hamsters]. The dog LC50 was determined to be greater than 500 mg/m3 since all the test animals survived exposure to this concentration. These values show that rats and mice were the most sensitive species with a declining response in guinea pigs, hamsters and dogs. Lung weights were increased at all exposure concentrations in rats, mice and hamsters. Lung weights were increased in guinea pigs at exposure concentrations of 100 mg/m3 and above. Lung weights in dogs were increased only at the 500 mg/m3 exposure concentration. Significant pathological changes were limited to the lungs and were more common in animals which died prior to scheduled sacrifice. Grossly, these lung changes consisted of red discoloration, edema, emphysema, and surface irregularities. Microscopic findings in the lungs included acute congestion and hemorrhage and, less commonly, acute interstitial inflammation.
Hoffman
G M
GM
Bio/dynamics, Inc. East Millstone, NJ 08875.
Newton
P E
PE
Thomas
W C
WC
Birnbaum
H A
HA
Kennedy
G L
GL
D000280:Administration, Inhalation; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006224:Cricetinae; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004852:Epoxy Compounds / Q000633:toxicity*; D005027:Ethylene Oxide / Q000633:toxicity*; D006168:Guinea Pigs; D008297:Male; D008647:Mesocricetus; D051379:Mice; D010316:Particle Size; D011108:Polymers / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D004852:Epoxy Compounds; D011108:Polymers; D005027:Ethylene Oxide; C009068:propylene oxide