Effects of glimepiride and glibenclamide on insulin and glucagon secretion by the perfused rat pancreas.
Glimepiride and glibenclamide act apparently in a closely comparable manner upon both insulin and glucagon release. Except for the decreased efficiency of D-glucose in suppressing glucagon release after a prior exposure of the pancreas to the hypoglycemic sulfonylureas, no evidence was obtained to suggest that a positive glucagonotropic action of the latter drugs would counteract their hypoglycemic action, as mainly attributable to stimulation of insulin release.
Ledercq-Meyer
V
V
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
Akkan
A G
AG
Marchand
J
J
Malaisse
W J
WJ
D000818:Animals; D005260:Female; D005934:Glucagon / Q000378:metabolism*; D005905:Glyburide / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013453:Sulfonylurea Compounds / Q000494:pharmacology*; D013997:Time Factors
D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds; C057619:glimepiride; D005934:Glucagon; D005905:Glyburide