Amino acid assay of vestibular nuclei 10 months after unilateral labyrinthectomy in squirrel monkeys.
Amino acids were assayed by HPLC in bilateral vestibular nuclei from normal squirrel monkeys (n = 3) and those 10-month post-unilateral labyrinthectomy (n = 4). Findings of vestibulo-spinal and vestibulo-oculomotor functions were identical for both groups. No left-right asymmetry of amino acids was found within either group, nor between groups with the exception of GABA: GABA was significantly reduced in the bilateral vestibular nuclei of the 10-month post-lesion animals. This may be indicative of a reduction of cerebello-vestibular inhibitory control which could be secondary to the reduction of excitatory inputs to the system.
Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030.
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Henley
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Igarashi
D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D001259:Ataxia / Q000503:physiopathology; D002851:Chromatography, High Pressure Liquid; D007758:Ear, Inner / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D012453:Saimiri; D014726:Vestibular Nuclei / Q000737:chemistry*; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D000596:Amino Acids; D009419:Nerve Tissue Proteins; D005680:gamma-Aminobutyric Acid