[Insular modifications in glycerophosphate dehydrogenase in diabetes].
In the model of non-insulin-dependent diabetes found in adult rats injected with streptozotocin during the neonatal period, the activity of the mitochondrial glycerophosphate dehydrogenase is severely reduced in pancreatic islets. This coincides with a decreased contribution of aerobic to total glycolysis in intact islets and could account for the preferential impairment of the insulin secretory response to glucose.
Laboratoire de Médecine expérimentale, Université libre de Bruxelles.
W J
WJ
Malaisse
J
J
Rasschaert
D000818:Animals; D002237:Carbohydrate Dehydrogenases / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D006019:Glycolysis; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000201:enzymology*; D008928:Mitochondria / Q000201:enzymology; D051381:Rats
D007328:Insulin; D002237:Carbohydrate Dehydrogenases; C056470:3-glycerophosphate dehydrogenase
Altération insulaire de la navette du glycerophosphate dans le diabète.