Administration of sulfhydryls to stimulate the healing of ischemia-induced acute gastric mucosal injury in the rat.
The sulfhydryl-containing agents DL-cysteine and DL-methionine-methyl sulfonium chloride (1-5%), administered orally by gavage for 4 days, stimulate the healing of acute ischemic injury of the rat gastric mucosa produced by 5 mg/kg of reserpine or 50 mg/kg of serotonin (5-hydroxytryptamine) injected once ip without influencing acid secretion (i.e., by cytoprotective mechanisms).
University Department of Surgery, Royal Infirmary, Glasgow, UK.
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Salim
D000818:Animals; D003545:Cysteine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D007511:Ischemia / Q000188:drug therapy*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013997:Time Factors; D014814:Vitamin U / Q000502:physiology
D013438:Sulfhydryl Compounds; D012701:Serotonin; D014814:Vitamin U; D012110:Reserpine; D003545:Cysteine