[Toxicological evaluation of saccharose carbonic acid esters in basic subchronic feeding trials with rats. 1. Effect of saccharose fatty acid polyester].
Groups of male and female rats received a sucrose fatty acid polyesters containing product (SPE) in their diet for 13 weeks at levels of 0, 5, 10 or 15%. Additional groups were pair-fed to the high-dose SPE-group (standard diet, 92.5%) or given food containing 7.5% hydrogenated lard (HF) or 4.5% fatty acid ethyl ester (FEE). Compared to the controls, there were increases in the food intake in males and females of the SPE-groups, HF- group and FEE-group. Male rats fed SPE showed increases in serum urea nitrogen at all levels, in serum alkaline phosphatase activity and urinary glucose excretion at 10 and 15%, in serum leucine amino-peptidase at 15%. In females dietary SPE increased the blood glucose content and serum alkaline phosphatase activity at 15% and the serum leucine aminopeptidase activity at 10 and 15%.
Zentalinstiut für Ernährung in Potsdam-Rehbrücke, Bundesrepublik Deutschland.
H J
HJ
Lewerenz
G
G
Mieth
D W
DW
Bleyl
R
R
Plass
H
H
Schliemann
D000469:Alkaline Phosphatase / Q000097:blood; D000821:Animal Feed; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001806:Blood Urea Nitrogen; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D005227:Fatty Acids / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007931:Leucyl Aminopeptidase / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D051381:Rats; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D001786:Blood Glucose; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D013395:Sucrose; C013692:sucrose polyester; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase
Toxikologische Beurteilung von Saccharosecarbonsäureestern auf der Grundlage subchronischer Fütterungsversuche mit Ratten. 1. Mitt. Wirkung von Saccharosefettsäurepolyester.