Lack of genotoxicity of cross-linked acrylate polymers in four short-term genotoxicity assays.
Three cross-linked polyacrylate polymers containing either methylenebis-acrylamide (MBA), trimethylolpropane triacrylate (TMPTA), or triallylamine (TAA) cross-linkers were tested for genotoxicity with the Salmonella mammalian microsome assay, the L5178Y mouse lymphoma TK +/- assay, the unscheduled DNA synthesis assay in primary cultures of rat hepatocytes, and the in vivo bone marrow cytogenetic assay. The results indicate that none of the three polymers was genotoxic in these assays.
Miami Valley Laboratories, Procter & Gamble Co., Cincinnati, OH 45239-8707.
E D
ED
Thompson
J L
JL
Seymour
M J
MJ
Aardema
R A
RA
LeBoeuf
B L
BL
Evans
D B
DB
Cody
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000178:Acrylamides / Q000494:pharmacology*; D000179:Acrylates / Q000494:pharmacology*; D000499:Allylamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001711:Biotransformation; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004261:DNA Replication / Q000187:drug effects; D007940:Leukemia L5178; D008099:Liver / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000494:pharmacology*; D011108:Polymers; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000178:Acrylamides; D000179:Acrylates; D009153:Mutagens; D011108:Polymers; C071225:triallylamine; D000499:Allylamine; C027993:trimethylolpropane triacrylate; D015127:9,10-Dimethyl-1,2-benzanthracene; C021221:N,N'-methylenebisacrylamide