Tegafur-induced acral hyperpigmentation.
Four patients with colorectal cancer treated with tegafur (a fluoropyrimidine structurally similar to 5-fluorouracil) noted a macular, spotted hyperpigmentation limited to the palms, soles, nails, and glans penis. Histopathologic examination disclosed epidermal basal hyperpigmentation with a lentiginous pattern. Mucocutaneous lesions resolved spontaneously two months after treatment was discontinued. This peculiar phenomenon seems to represent a previously unreported side effect of this cytotoxic drug.
Department of Dermatology, Hospital de Girona, Spain.
E
E
Llistosella
A
A
Codina
R
R
Alvarez
R M
RM
Pujol
J M
JM
de Moragas
D000368:Aged; D005260:Female; D005533:Foot Dermatoses / Q000139:chemically induced / Q000473:pathology; D006229:Hand Dermatoses / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology; D005641:Tegafur / Q000009:adverse effects*
D005641:Tegafur