Familial recurring cardiac myxoma.
A 34-year-old woman presented with her fourth occurrence of an atrial myxoma and a right lower lung field mass. Her surgical history was extensive. In addition to resection of three previous atrial myxomas, she had undergone resection of her adrenal glands as a teenager because of Cushing's syndrome, and a hysterectomy at age 26 revealed a myxoid leiomyoma. Family history was remarkable as a maternal uncle and daughter died from embolic complications of left atrial myxomas and her sister previously had a left atrial myxoma resected. The patient underwent uncomplicated removal of the myxoma, and resection of the lung mass revealed a granuloma. A review of typical and atypical aspects of cardiac myxomas is provided including a rare and recently described syndrome of familial cardiac myxoma associated with Cushing's syndrome, spotty skin pigmentation and other myxoid tumors.
Haught
W H
WH
Department of Medicine, University of Florida College of Medicine, Gainesville.
Alexander
J A
JA
Conti
C R
CR
D000328:Adult; D001706:Biopsy; D003480:Cushing Syndrome / Q000150:complications*; D004452:Echocardiography; D004947:Esophagus / Q000000981:diagnostic imaging; D005260:Female; D005799:Genes, Dominant; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006325:Heart Atria; D006338:Heart Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D009232:Myxoma / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D010375:Pedigree; D010784:Photomicrography; D012008:Recurrence