Mechanisms of T lymphocyte activation.
The proliferation of T lymphocytes in response to an antigenic stimulus requires the successive ligation of a range of T lymphocyte receptors by MHC-presented antigen, molecules expressed on the surfaces of accessory cells and lymphokines. A range of intracellular signalling systems are involved, with the possibility of alternative activation pathways utilising different intracellular signalling systems, though protein kinase C activation appears to play a key role. Appreciation of the complexity of the response may allow more selective clinical modulation of T lymphocyte-dependent immunological responses.
School of Biological Sciences, University of Sussex, Brighton, U.K.
J E
JE
Kay
D015703:Antigens, CD / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008934:Mitogens; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D008934:Mitogens