POMC gene expression in mouse and hamster melanoma cells.
Expression of mRNA hybridizable to murine POMC cDNA, and immunoreactivity specific for POMC derived peptide, beta-endorphin, are reported for the first time in one murine and two hamster melanoma lines. The apparent sizes of POMC mRNA transcript were 3.5, 1.5 and 1 kb. It is suggested that POMC gene expression may be involved in the autoregulation of the melanoma phenotype at the cellular and tissue levels.
Department of Immunology and Microbiology, Albany Medical College, NY 12202.
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Slominski
D000818:Animals; D015152:Blotting, Northern; D002460:Cell Line; D006224:Cricetinae; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008546:Melanoma, Experimental / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D008647:Mesocricetus; D051379:Mice; D009368:Neoplasm Transplantation; D011333:Pro-Opiomelanocortin / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000494:pharmacology
D014443:Tyrosine; D007980:Levodopa; D011333:Pro-Opiomelanocortin