Auditory nerve of the normal and jaundiced rat. II. Frequency selectivity and two-tone rate suppression.
This study is the continuation of the functional probing of the auditory periphery in the normal and jaundiced rat. Threshold tuning curves from normal rat auditory nerve fibers were comparable to those reported in other mammals. Life-long unconjugated hyperbilirubinemia does not appear to have a widespread, demonstrable effect on cochlear frequency selectivity and sensitivity as measured by the shapes of FTCs of single auditory nerve fibers. Most fibers from the jj Gunn rats had threshold tuning curves as sharp as those from control animals (Jj Gunn and Long-Evans). Any difference seems to lie in a greater threshold variability, particularly for the high-SR fibers, for the Gunn rat strain. Two-tone rate suppression, particularly above CF, was detected in most fibers from the three groups of rats. The optimal suppression frequency (SF) as a function of CF displayed the same progression. Suppression thresholds at any given CF were generally higher for high-SR fibers than for low-SR fibers for all three groups of animals.
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Waisman Center on Mental Retardation and Human Development, University of Wisconsin-Madison 48109-0506.
D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006932:Hyperbilirubinemia / Q000235:genetics / Q000503:physiopathology; D007565:Jaundice / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011911:Rats, Gunn; D000159:Vestibulocochlear Nerve / Q000502:physiology / Q000503:physiopathology*