[Swelling of the knee, fatigue].
A 43 year old man was admitted because of fatigue and swelling of the knees. Swelling of both knees, acropachy and turtle-back nails were registered during clinical investigation and laboratory tests showed leucocytosis, increased blood-sedimentation rate and alkaline phosphatase. Leucine aminopeptidase was normal. X-ray showed symmetric metaphyseal periosteal reactions on femora and tibiae of both sides compatible with hypertrophic osteoarthropathy. A parahilar round tumor measuring 5 x 7 cm infiltrating the right upper lobe was detected on chest x-ray suggestive of lung cancer. Pierre-Marie-Bamberger syndrome was diagnosed (hypertrophic osteoarthropathy associated with cancer of the lung). Under radiotherapy to the tumor the osteoarthropathy subsided and alkaline phosphatase returned to normal.
Medizinische Poliklinik, Universitätsspital Zürich.
M
M
Billeter
E
E
Streit
W
W
Deuel
D000328:Adult; D003937:Diagnosis, Differential; D005221:Fatigue / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007592:Joint Diseases / Q000209:etiology; D007719:Knee Joint; D008297:Male; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000175:diagnosis*
Knieschwellung, Müdigkeit.