Increased response to cisplatin after long-term serial passage of a squamous cell carcinoma xenograft.
We have retrospectively investigated the response to cisplatin of a squamous cell carcinoma of the head and neck xenografted to nude mice during nine years of serial transplantation. Tumour growth rate decreased gradually. After nine years and over 100 passages, there was a sudden increase in cisplatin sensitivity. Histopathological examination showed that, of two histopathologically different subpopulations present in earlier passages, the predominant one was no longer detectable. The DNA-index did not change.
Department of Oto-rhino-laryngology, University Hospital, Lund, Sweden.
R
R
Rydell
S
S
Lybak
J
J
Wennerberg
R
R
Willén
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002454:Cell Differentiation; D002455:Cell Division / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005434:Flow Cytometry; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009296:Nasal Cavity; D009368:Neoplasm Transplantation
D000970:Antineoplastic Agents; D002945:Cisplatin