On the handedness of the scaffolds of sister chromatids.
We discuss a mechanical model for the mirror-symmetric inversion of the scaffold's helicity of replicated chromatids vis-a-vis that of their templates. The paper ends with comments on the orientability of certain genes and on the effects of such topologies upon (a)symmetric gene expression, in general. Our model and its generalizations apply only to the special subclass of 'coiled' chromatids whose statistical distribution in the genome of normal and of malignant cells is not known precisely.
USC School of Medicine, Los Angeles 90033.
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Matioli
D001696:Biomechanical Phenomena; D002842:Chromatids / Q000648:ultrastructure*; D005786:Gene Expression Regulation; D008957:Models, Genetic; D012854:Sister Chromatid Exchange / Q000235:genetics