The effect of soluflazine on sleep in rats.
Soluflazine, a specific adenosine transport inhibitor, was intracerebroventricularly administered to rats in a dose range of 10, 25, and 50 nmoles. At a dose of 50 nmoles, soluflazine decreased waking and increased sleep during the first hour of EEG recording. Our previous work has shown that chronic intracerebroventricular administration of soluflazine to rats decreased radioligand binding to adenosine A1 and A2 receptors in specific brain regions. The present data show that administration of an adenosine transport inhibitor to rats produces a transient hypnotic effect presumably through increases in synaptic adenosine levels.
Department of Pharmacology, University of Illinois, College of Medicine, Chicago 60612.
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O'Connor
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Stojanovic
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Radulovacki
D000818:Animals; D004569:Electroencephalography; D007276:Injections, Intraventricular; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011983:Receptors, Purinergic / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D010879:Piperazines; D011983:Receptors, Purinergic; C054695:soluflazine