[Alternating rifampicin and ceftriaxone for Neisseria meningitidis eradication in contacts].
Following the occurrence of a case of meningococcal disease in a kibbutz, extensive preventive measures were instituted, consisting of alternate courses of rifampicin (10 mg/kg for 2 consecutive days) and ceftriaxone (single IM injection of 125 mg). Throughout the observation period Neisseria meningitidis was absent from oropharyngeal secretions of all those treated, but was found in those of an untreated control group. The alternate use of rifampicin and ceftriaxone should be considered for the long-term prevention of the occurrence of oropharyngeal carriers of Neisseria meningitidis.
Shehab
S
S
Acre Public Health Office, Israel Ministry of Health.
Leitner
L
L
Bogokowsky
B
B
Epstein
I
I
Swartz
T A
TA
D002353:Carrier State / Q000382:microbiology; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D008585:Meningitis, Meningococcal / Q000517:prevention & control; D008589:Meningococcal Infections / Q000517:prevention & control*; D009345:Neisseria meningitidis / Q000187:drug effects; D009960:Oropharynx / Q000382:microbiology; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use*
D002443:Ceftriaxone; D012293:Rifampin