Maternal transmission of SIVsmm in rhesus macaques.
Fifteen SIV-infected rhesus monkeys delivered 13 livebirths and two stillbirths; one livebirth died at three days of age. While all infants were culture-negative for SIV at birth, nine had maternal antibodies that disappeared by six months of age. Three infants subsequently seroconverted and became virus positive at 9-15 months. Milk samples from all mothers were virus-negative at parturition but samples from four animals were virus-positive at nine and 12 months. This study documents maternal transmission of SIV and suggests transmission by breast-feeding.
Yerkes Primate Research Center, Emory University, Atlanta, GA 30322.
H M
HM
McClure
D C
DC
Anderson
P N
PN
Fultz
A A
AA
Ansari
T
T
Jehuda-Cohen
F
F
Villinger
S A
SA
Klumpp
W
W
Switzer
E
E
Lockwood
A
A
Brodie
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D001942:Breast Feeding; D004195:Disease Models, Animal; D005260:Female; D015658:HIV Infections / Q000635:transmission*; D007112:Immunity, Maternally-Acquired; D008253:Macaca mulatta; D008892:Milk / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D016097:Simian Acquired Immunodeficiency Syndrome / Q000635:transmission*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000302:isolation & purification*
D000914:Antibodies, Viral