GABAergic-serotonergic interactions in regulating lordosis.
The GABAB agonist, baclofen, causes a dose-dependent decrease in lordosis, and this effect is attenuated following hypothalamic serotonin, (5-HT) lesions. Baclofen administration is associated with decreased 5-HT activity in the medial preoptic (mPOA) and ventromedial nuclei and enhanced 5-HT activity in the midbrain central gray, and with enhanced norepinephrine activity in the mPOA. Interactions between gamma-aminobutyric acid (GABA) and 5-HT may, therefore, be important for the activation of lordosis.
Luine
V
V
Department of Psychology, Hunter College, City University of New York, NY 10021.
Cowell
J
J
Frankfurt
M
M
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism; D010052:Ovariectomy; D010293:Pargyline / Q000494:pharmacology; D011187:Posture; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D011374:Progesterone; D004958:Estradiol; D005680:gamma-Aminobutyric Acid; D010293:Pargyline; D001418:Baclofen; D009638:Norepinephrine