Pharmacogenetics and drug metabolism: an Irish perspective.
Genetic factors, particularly in relation to control of liver drug metabolism, are a major cause of variability in the response to drugs. In 145 Irish subjects 48% were fast acetylators of sulphadimidine in contrast to 80% in Chinese subjects. Eleven (7.6%) of our Irish population showed an improved ability to oxidise delrisoquine. The therapeutic implications of these findings are discussed.
Department of Pharmacology and Therapeutics, Trinity College Medical School, St. James's Hospital, Dublin.
P
P
Holland
M
M
Barry
J
J
Feely
D000107:Acetylation; D000328:Adult; D002681:China; D003647:Debrisoquin / Q000378:metabolism*; D006801:Humans; D007494:Ireland; D008660:Metabolism / Q000235:genetics; D010084:Oxidation-Reduction; D010641:Phenotype; D011110:Polymorphism, Genetic; D013418:Sulfamethazine / Q000378:metabolism*
D013418:Sulfamethazine; D003647:Debrisoquin