Antigen-induced modulation of autonomic and sensory neurons in vitro.
We have addressed the hypothesis that the excitability of peripheral neurons is affected during immediate hypersensitivity reactions. Guinea pigs were actively sensitized to ovalbumin. The electrical membrane properties of neurons within the superior cervical ganglion, bronchial parasympathetic ganglion and nodose ganglion were evaluated before, during and after antigen challenge. In all preparations, antigen stimulation induced the release of histamine and arachidonic acid metabolites. Our results support the hypothesis that the excitability of sympathetic, parasympathetic and sensory C-type neurons may be increased during immediate hypersensitivity reactions.
Undem
B J
BJ
Department of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Md.
Myers
A C
AC
Weinreich
D
D
D000200:Action Potentials; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D006168:Guinea Pigs; D006969:Hypersensitivity, Immediate / Q000209:etiology*; D066298:In Vitro Techniques; D008407:Mast Cells / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology*