Eltenac, a new anti-inflammatory and analgesic drug for horses: clinical aspects.
Two controlled studies to determine efficacy in the horse were performed with eltenac, a new injectable, non-steroidal anti-inflammatory drug (NSAID). Clinical trials were carried out with a dose rate of 1 mg/kg body weight in a randomized, placebo-controlled, double-blind design to assess therapeutic efficacy in acute inflammatory disorders and in animals with orthopaedic conditions. In a preliminary pharmacokinetic investigation in six horses mean elimination half-life was 1.7 h after i.v. administration. In the first clinical study, analgesic activity on pain-related lameness was determined in a total of 64 horses. Pain was assessed using a rating scale. Compared with the placebo treatment, eltenac produced significant pain relief after a single i.v. injection for a period of 24 h. In the second trial the anti-oedematous effect was determined in post-operative wound swelling following castration in two groups of 10 colts. After surgery, the horses received either an injection of 1 mg/kg eltenac or a placebo injection on three consecutive days. Swelling was assessed by measuring the diameter of the external preputial fold using two methods: callipers and a rating scale of 0 to 3. Additionally, photographs were taken on days 1, 2 and 4. Compared with the placebo treatment, eltenac inhibited pain and swelling significantly. The effect was maintained for up to 48 h after the last injection.
Prügner
W
W
Byk Gulden Research Centre, Konstanz, Germany.
Huber
R
R
Lühmann
R
R
D000814:Aniline Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004311:Double-Blind Method; D004487:Edema / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary; D007794:Lameness, Animal / Q000150:complications; D008297:Male; D009919:Orchiectomy / Q000662:veterinary; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D011183:Postoperative Complications / Q000188:drug therapy; D013876:Thiophenes / Q000493:pharmacokinetics / Q000627:therapeutic use*
D000814:Aniline Compounds; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013876:Thiophenes; C071200:eltenac