[The analgesic and anti-stress effects of middle-molecule peptides in a normal state and in thermal burns].
Fractions of medium-weight molecular peptides (MWP) were isolated from blood of intact dogs and those with burns, which possessed the property of increasing the latency of the pain reaction in mice by 23-28% after intravenous infusion. The analgesic properties of MWP change essentially in the first 24 hours after the burn. The dose dependences of the antinociceptive effect of MWP have a marked non-linear character. The studied MWP fractions also prevent involution of the thymus induced by 9-hour immobilization stress. An MWP fraction was isolated from the blood of dogs 12 hours after a burn; its intravenous infusion led to reduction of the thymus equal to that caused by 9-hour immobilization. The relationship of adaptational and damaging effects of MWP in thermal burns in discussed.
Volchegorskiĭ
I A
IA
Val'dman
B M
BM
Skobeleva
N A
NA
Tseĭlikman
V E
VE
Lifshits
R I
RI
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D001798:Blood Proteins / Q000302:isolation & purification / Q000627:therapeutic use*; D002056:Burns / Q000097:blood / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D008970:Molecular Weight; D010146:Pain / Q000097:blood / Q000188:drug therapy; D010455:Peptides / Q000302:isolation & purification / Q000627:therapeutic use*; D013312:Stress, Physiological / Q000097:blood / Q000188:drug therapy*
D000700:Analgesics; D001798:Blood Proteins; D010455:Peptides
Anal'geticheskie i antistressornye éffekty srednemolekuliarnykh peptiodov v norme i pri termichekikh ozhogakh.