Bioactive polymers 54. Pharmacological properties of modified neomycin.
Modified neomycin prepared by the ionic coupling on xanthan with an activity of 380 UI/mg was characterized in regard to its in vitro and in vivo release rate and therapeutic action with artificial tear eluent. The dynamic system in vitro release showed that after 4 h, there appears a "zero-order" kinetic. Ophthalmic inserts were prepared from modified neomycin and they are used in treating bacterial conjunctivitis. Sterilization of the conjunctival sac is obtained 12 h after insert administration.
Polytechnic Institute of Jassay, Department of Macromolecular Technology, Romania.
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Popa
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Vancea
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Mungiu
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Costin
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Dumitriu
D003234:Conjunctivitis, Bacterial / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D006801:Humans; D009355:Neomycin / Q000737:chemistry* / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000188:drug therapy*
D003692:Delayed-Action Preparations; D009355:Neomycin