The effects of thyroid hormones and starvation on hepatic mitochondrial nucleic acids of rainbow trout (Oncorhynchus mykiss).
Twenty four hours after an intraperitoneal injection of thyroxine (T4; 4.4, 44 ng/g body wt) or triiodothyronine (T3; 3.3, 33 ng/g body wt), DNA and RNA were significantly reduced in isolated liver mitochondria of rainbow trout. Total liver DNA was increased with the higher doses in both T4- and T3-injected specimens while total RNA was significantly reduced with the same doses. Total circulating plasma T4 was reduced with the injections of T3 or starvation, and plasma T3 was increased severalfold with the T3 injections. Plasma T4 also increased fivefold after a higher dose of T4 injection while starvation significantly reduced the concentration, when measured by radioimmunoassay.
Department of Zoology, University of Kerala, Trivandrum, India.
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D000818:Animals; D004272:DNA, Mitochondrial / Q000032:analysis*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis*; D013217:Starvation / Q000378:metabolism; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology*; D014284:Triiodothyronine / Q000097:blood / Q000494:pharmacology*; D014337:Trout / Q000502:physiology*
D004272:DNA, Mitochondrial; D012333:RNA, Messenger; D014284:Triiodothyronine; D013974:Thyroxine