Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.
Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin-6 (IL-6) although LIF and IL-6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 'signal-transducing' component of the IL-6 receptor and to the G-CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross-hybridization and share 70% amino acid sequence identity to the human sequence.
Immunex Corporation, Seattle, WA 98101.
D P
DP
Gearing
C J
CJ
Thut
T
T
VandeBos
S D
SD
Gimpel
P B
PB
Delaney
J
J
King
V
V
Price
D
D
Cosman
M P
MP
Beckmann
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD; D001483:Base Sequence; D015152:Blotting, Northern; D050822:Cytokine Receptor gp130; D004247:DNA / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D006131:Growth Inhibitors; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; D008222:Lymphokines / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics; D018121:Receptors, Cytokine; D011971:Receptors, Immunologic / Q000235:genetics* / Q000378:metabolism; D053606:Receptors, OSM-LIF; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D015398:Signal Transduction; D013379:Substrate Specificity; D014158:Transcription, Genetic
D015703:Antigens, CD; D006131:Growth Inhibitors; C494199:IL6ST protein, human; C494200:Il6st protein, mouse; D015850:Interleukin-6; C507837:LIF protein, human; C507840:LIFR protein, human; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; C507838:Lif protein, mouse; C507841:Lifr protein, mouse; D008222:Lymphokines; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D018121:Receptors, Cytokine; D011971:Receptors, Immunologic; D053606:Receptors, OSM-LIF; D050822:Cytokine Receptor gp130; D004247:DNA