Pig weaning weight and changes in hematology and blood chemistry of sows injected with recombinant porcine somatotropin during lactation.
Weaning weight of pigs on d 18 to 21 of age was used to determine the effects of recombinant porcine somatotropin (rpST) on lactational performance of their dams. Crossbred Landrace x Yorkshire sows (n = 180, 202 to 270 kg BW) were assigned to receive daily i.m. injections of either 0, 8, or 16 mg of rpST on lactation d 7 to 20. Initially, injections of 16 mg of rpST/d caused 100% mortality (four sows); thus, a dose of 4 mg of rpST/d replaced 16 mg. Subsequently, 5 of 19 and 1 of 17 sows died in response to daily injections of 8 and 4 mg of rpST, respectively, resulting in termination of the experiment. Before termination, 48 sows (16 from each of the 0-, 4-, and 8-mg treatment groups) completed a lactation of 18 to 21 d in duration. Analysis of these data indicated that daily injection of lactating sows with rpST increased (P less than .05) weaning weight of pigs only if they were from litters that averaged greater than or equal to 2.6 kg/pig on lactation d 7. The BW of sows was decreased by rpST (P = .07). Subsequent experiments revealed 1) that rpST-induced death of lactating sows was caused from hemorrhaging of ulcers that developed at the pars esophagea, 2) that there was vacuolation of the liver and kidney of dead sows, and 3) that daily injection of 16 mg of rpST into nonlactating growing pigs (50 to 100 kg BW) for 28 d did not cause death or any observable illness in spite of 100% mortality of lactating sows after two to nine injections.
Upjohn Company, Kalamazoo, MI 49001.
V G
VG
Smith
A D
AD
Leman
W J
WJ
Seaman
F
F
VanRavenswaay
D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007273:Injections, Intramuscular / Q000662:veterinary; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007774:Lactation / Q000097:blood / Q000187:drug effects*; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000662:veterinary; D011388:Prolactin / Q000097:blood; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000662:veterinary; D013552:Swine / Q000097:blood / Q000254:growth & development*; D013553:Swine Diseases / Q000139:chemically induced; D014886:Weaning; D015430:Weight Gain / Q000187:drug effects*
D006454:Hemoglobins; D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I; D011388:Prolactin; D013006:Growth Hormone