Absorption of micronized progesterone from a nonliquefying vaginal cream.
An improved delivery method to achieve sustained physiological P levels would be useful. Based on this single-dose pharmacokinetic study, micronized P prepared in a nonliquefying vaginal cream holds promise as a convenient method to achieve this goal with a single daily application.
Nursing Department, National Institutes of Health, Bethesda, Maryland 20892.
L M
LM
Kimzey
J
J
Gumowski
G R
GR
Merriam
G J
GJ
Grimes
L M
LM
Nelson
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D011374:Progesterone / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D012894:Sleep Stages; D014622:Vaginal Creams, Foams, and Jellies
D014622:Vaginal Creams, Foams, and Jellies; D011374:Progesterone