Histological changes of vestibular nerves and ganglion cells in the acoustic tumor in relation to clinical functions.
The superior vestibular nerves and vestibular ganglion cells were observed electron microscopically in acoustic tumors removed surgically from 15 patients. Furthermore, the sensory cells of the vestibular organs were examined. Histological changes of vestibular nerves and ganglion cells were compared with the caloric responses of the patients. In most cases, the degree of degeneration of myelinated nerve fibers was proportional to the reduced responses of vestibular nerves. The myelinated nerve fibers decreased in number and showed some features of demyelination. The alteration of vestibular ganglion cells was unremarkable in comparison with vestibular nerves. In some cases, the number of lipofuscin granules, vacuolar organelles and amorphous materials markedly increased in the ganglion cells. However, the sensory cells of the vestibular organs appeared normal.
Kanda
T
T
Department of Otolaryngology, Chiba University, Japan.
Komatsuzaki
A
A
Yaku
Y
Y
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000502:physiology; D009410:Nerve Degeneration; D009464:Neuroma, Acoustic / Q000473:pathology* / Q000503:physiopathology; D014725:Vestibular Nerve / Q000473:pathology* / Q000503:physiopathology