Alpha-glucosidase inhibition prevents increased collagen fluorescence in experimental diabetes.
1. The effect of the alpha-glucosidase inhibitor Acarbose on collagen fluorescence reflecting formation of advanced glycation end products was examined in streptozotocin-diabetic rats. 2. Treatment with Acarbose for eight weeks after induction of diabetes prevented the increased fluorescence in skin and tail tendon collagen associated with untreated diabetes. 3. Acarbose improves integrated glycemic control and beneficially influences the consequences of excess glycation in long-lived connective tissue proteins.
University City Science Center, Philadelphia, PA 19104.
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Cohen
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Klepser
D020909:Acarbose; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D006031:Glycosylation; D008297:Male; D051381:Rats; D012867:Skin / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013710:Tendons / Q000378:metabolism; D014312:Trisaccharides / Q000627:therapeutic use
D020909:Acarbose; D001786:Blood Glucose; D003094:Collagen; D006442:Glycated Hemoglobin; D065089:Glycoside Hydrolase Inhibitors; D014312:Trisaccharides