Time course of cellular infiltration in the nasal mucosa during the immediate allergic reaction.
In 23 patients with allergic rhinitis, biopsies of the nasal mucous membrane were taken at one of the following times after challenge of one nostril with allergen: 0 (baseline) (n = 7), 1/2 h (n = 6), 1 h (n = 5), and 2 h (n = 5). In the nostril stimulated by allergen there was a transient early phase influx of eosinophils while the numbers of stainable mast cells decreased, probably due to their degranulation. In the contralateral unstimulated nostril, there was no change in numbers of eosinophils but the numbers of stainable mast cells decreased. These results support the proposed role in allergic rhinitis of the mast cell and eosinophil, and suggest that the eosinophil may be a rapidly mobilized effector cell.
St. Bartholomew's Centre for Clinical Research, Department of Respiratory Medicine, St. Bartholomew's Hospital, London, UK.
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S
Lozewicz
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E
Gomez
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Chalstrey
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Gatland
R J
RJ
Davies
D000281:Administration, Intranasal; D000328:Adult; D000403:Airway Resistance; D000485:Allergens / Q000276:immunology*; D001985:Bronchial Provocation Tests; D002465:Cell Movement / Q000276:immunology; D004804:Eosinophils / Q000502:physiology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000473:pathology*; D008297:Male; D008407:Mast Cells / Q000166:cytology; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology*; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal
D000485:Allergens