High propionic acid fermentations and mineral accumulation in the cecum of rats adapted to different levels of inulin.
The digestive and metabolic effects of inulin (from chicory) were studied in rats adapted to semipurified diets containing 0, 5, 10 or 20% inulin (wt/wt). Moderate levels of inulin (5-10%) did not significantly affect food intake or body weight gain. Dietary inulin resulted in considerably greater cecal fermentation and a significantly greater intraluminal concentration of propionate (peaking at 58.4 mmol/L). A lower concentration of acetate (42.6 mmol/L) was observed in rats fed 20% inulin. Lactic fermentations were observed in rats fed the 10 or 20% inulin diets. The cecal pool of volatile fatty acids tended to reach a plateau in rats fed diets containing more than 10% inulin (up to 600-700 mumol), but volatile fatty acid absorption was a slightly hyperbolic function of the dietary inulin level. Butyrate absorption was proportionally lower than that of propionate. Inulin-containing diets induced an enlargement of the cecal pool of calcium, phosphate and (to a lesser extent) magnesium. There was also an enhanced absorption of these divalent cations. The cecal pool of bile acids was greater in rats fed inulin, and this oligosaccharide displayed a slight hypocholesterolemic effect, even in rats fed the 5% inulin diet. However, plasma triglycerides were depressed only in rats fed the 20% inulin diet. In conclusion, inulin seems very effective in promoting propionic fermentation and in enhancing the calcium content of the large intestine. However, high levels of inulin (greater than 10%) may affect growth in rats and lead to acidic (pH 5.65) cecal fermentation.
Levrat
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MA
Laboratoire des Maladies Métaboliques, Institut National de la Recherche Agronomique Clermont Ferrand-Theix, Ceyrat, France.
Rémésy
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C
Demigné
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C
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002432:Cecum / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D002784:Cholesterol / Q000096:biosynthesis / Q000097:blood; D004435:Eating / Q000187:drug effects; D005227:Fatty Acids / Q000096:biosynthesis; D005285:Fermentation; D007408:Intestinal Absorption / Q000187:drug effects; D007444:Inulin / Q000494:pharmacology*; D008297:Male; D008903:Minerals / Q000378:metabolism*; D011422:Propionates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000096:biosynthesis / Q000097:blood
D005227:Fatty Acids; D008903:Minerals; D011422:Propionates; D014280:Triglycerides; D007444:Inulin; D002784:Cholesterol; C029658:propionic acid