Bronchial granular-cell tumor. Report of a case with preoperative cytologic diagnosis on bronchial brushings and immunohistochemical studies.
A 42-year-old man presented with a polypoid endobronchial mass of the right apical segmental bronchus. Bronchial brushing smears contained clusters of cells exhibiting abundant diffusely granular cytoplasm with indistinct borders. A cytologic diagnosis of granular-cell tumor was rendered. Histologic examination of the upper right lobectomy specimen provided confirmation. Immunohistochemically, the granular cells strongly reacted with the S-100 protein antibody. This case demonstrates that the cytologic diagnosis of bronchial granular-cell tumor is possible if this lesion is considered in the differential diagnosis of lung tumors.
Guillou
L
L
Department of Pathology, University of Lausanne, Switzerland.
Gloor
E
E
Anani
P A
PA
Kaelin
R
R
D000328:Adult; D001980:Bronchi / Q000473:pathology*; D002467:Cell Nucleus / Q000648:ultrastructure; D003581:Cytodiagnosis / Q000379:methods; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D016586:Granular Cell Tumor / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male