Skin ulceration as sole manifestation of Langerhans-cell histiocytosis.
A 65-year-old black woman presented with skin ulceration of 5 years' duration which affected the left axilla, left groin, intergluteal folds and ano-perineal region. The diagnosis of Langerhans-cell histiocytosis (LCH) was confirmed by light and electron-microscopic findings and a positive S-100 stain. Extensive investigations failed to reveal any evidence of systemic involvement. A review of the literature suggests that this clinical picture as the sole manifestation of the disease is rare.
Department of Medicine, Baragwanath Hospital, Johannesburg, South Africa.
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Schulz
D000368:Aged; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D012867:Skin / Q000473:pathology; D012883:Skin Ulcer / Q000209:etiology* / Q000473:pathology