Additional bioactive heptenes from Melodorum fruticosum.
Four additional new bioactive heptenes, melodorinol [2], homomelodienone [4], 7-hydroxy-6-hydromelodienone [5], and homoisomelodienone [7] have been isolated from Melodorum fruticosum. These compounds were slightly to significantly cytotoxic to human tumor cell lines. Their structures have been determined by comparison of their 1H-nmr, 13C-nmr, and mass spectral data with those of prototype compounds (acetylmelodorinol [1], melodienone 3, and isomelodienone [6]).
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
J H
JH
Jung
C J
CJ
Chang
D L
DL
Smith
J L
JL
McLaughlin
S
S
Pummangura
C
C
Chaichantipyuth
C
C
Patarapanich
D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D001156:Artemia / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000475:Alkenes; D000972:Antineoplastic Agents, Phytogenic; C070779:melodorinol; C070781:homomelodienone; C070778:7-hydroxy-6-hydromelodienone; C070780:homoisomelodienone