Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate.
Redox phenomena seem to modulate activity of the N-methyl-D-aspartate receptor. Some reductants (ascorbate, hydroquinone) inhibit, while others (dithiothreitol, mercaptoethanol, penicillamine) potentiate NMDA receptor function. Ascorbate inhibits binding of [3H]glutamate and [3H]thienylcycohexylpiperidine to the NMDA receptor complex, and impedes NMDA-gated currents in isolated neurons; dithiothreitol-like reductants enhance NMDA-induced currents. The ability of reductants to alter function of the NMDA receptor is abolished by oxidation.
Majewska
M D
MD
Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224.
Bell
J A
JA
London
E D
ED
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000166:cytology; D004229:Dithiothreitol / Q000494:pharmacology; D004594:Electrophysiology; D066298:In Vitro Techniques; D015640:Ion Channel Gating / Q000187:drug effects; D007608:Kainic Acid / Q000378:metabolism; D007700:Kinetics; D008623:Mercaptoethanol / Q000494:pharmacology; D016202:N-Methylaspartate / Q000378:metabolism; D009474:Neurons / Q000187:drug effects; D010084:Oxidation-Reduction; D010396:Penicillamine / Q000494:pharmacology; D016318:Quisqualic Acid / Q000378:metabolism; D051381:Rats; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000378:metabolism*; D017981:Receptors, Neurotransmitter / Q000187:drug effects
D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D008623:Mercaptoethanol; D016202:N-Methylaspartate; D016318:Quisqualic Acid; D010396:Penicillamine; D001205:Ascorbic Acid; D007608:Kainic Acid; D004229:Dithiothreitol