title: Protection by interleukin 1 against lung toxicity caused by cyclophosphamide and irradiation.
abstract: Interleukin 1 has been shown to provide protection against the toxic effects of cyclophosphamide given in combination with localized irradiation of the lung. A single dose of 15 micrograms/kg interleukin 1 was given 24 h before cyclophosphamide (25-125 mg/kg) which was followed 1 day later by five daily exposures of 4.5 or 5.0 Gy, localized to the lung. Interleukin 1 significantly reduced early measurements of breathing rate for mice treated with high cyclophosphamide doses and irradiation, and at cyclophosphamide doses above 50 mg/kg, there was a significant reduction in the lethality from the combined treatment. At lower levels of cyclophosphamide, however, there seemed to be no effect.
authors.affiliation: Department of Radiation Oncology, Stanford University Medical Center, California 94305.
authors.forename: M J
authors.initials: MJ
authors.lastname: Dorie
authors.forename: G
authors.initials: G
authors.lastname: Bedarida
authors.forename: R F
authors.initials: RF
authors.lastname: Kallman
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity*; D007375:Interleukin-1 / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011829:Radiation Dosage; D011994:Recombinant Proteins
chemical_list: D007375:Interleukin-1; D011994:Recombinant Proteins; D003520:Cyclophosphamide