Influence of piecemeal necrosis on the compensatory increase of mitochondrial respiratory enzymes of the tumour-bearing liver: clinical study of 53 surgical cases.
The relationships between histological findings, adaptively increased cytochrome a(+a3) levels in chronic liver disease and complications after hepatectomy were studied in order to clarify the mechanism of mitochondrial derangement. The liver specimens of 53 hepatectomized patients were randomly evaluated by three independent hepatopathologists and were compared with cytochrome a(+a3) levels in the biopsied liver, the extent of operation and postoperative complications. The cytochrome a(+a3) concentrations did not show any significant difference between cases of chronic hepatitis and liver cirrhosis nor groups classified by regeneration. Severity of piecemeal necrosis was categorized into three groups: group A--minimal (n = 20); group B--moderate (n = 19); and group C--severe (n = 14). There were significant differences (P less than 0.01) in cytochrome a(+a3) concentrations between the groups (A: 99 +/- 9; B: 135 +/- 6; C: 155 +/- 10 pmol/mg of mitochondrial protein). Extensive hepatectomy, involving segmentectomy or more, was frequently complicated (four of nine, 44.4%) in group C, whereas there were few complications (two of 16, 12.5%) in group A cases in which extensive hepatectomy was performed. Evidence will be presented which will show that deranged liver function, as indicated by cytochrome a(+a3) levels, is closely correlated with piecemeal necrosis. This may be attributed to the damage of periportal hepatocytes which are the main sites of oxidative phosphorylation.
Maki
A
A
Second Department of Surgery, Kyoto University Medical School, Japan.
Sakai
Y
Y
Tanaka
A
A
Yamaoka
Y
Y
Ozawa
K
K
Kage
M
M
Kojiro
M
M
D006528:Carcinoma, Hepatocellular / Q000601:surgery / Q000648:ultrastructure*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000601:surgery / Q000648:ultrastructure*; D008115:Liver Regeneration / Q000502:physiology; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000201:enzymology*; D009336:Necrosis; D011183:Postoperative Complications / Q000209:etiology
D003576:Electron Transport Complex IV