An animal model of bulimia nervosa: opioid sensitivity to fasting episodes.
A group of female rats was deprived and maintained at 75-80% of body weight at three different times during development. Following recovery to normal weight, food intake was measured with and without butorphanol tartrate, a kappa-sigma agonist, 8 mg/kg SC. Animals with a history of deprivation (DEP) showed an increase in postrecovery feeding when they were tested at normal body weight and not food deprived. More importantly, butorphanol prolonged food intake in the 3-h eating test only in the rats with a developmental history of food restriction. A developmental history of fasting in eating disorders may trigger changes in opiate systems that result in atypical feeding behavior in the adult.
Hagan
M M
MM
Department of Psychology, University of Texas, El Paso 79968-0553.
Moss
D E
DE
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002032:Bulimia / Q000139:chemically induced / Q000523:psychology*; D002077:Butorphanol / Q000494:pharmacology*; D004195:Disease Models, Animal; D005215:Fasting / Q000502:physiology / Q000523:psychology*; D005260:Female; D005508:Food Deprivation / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D002077:Butorphanol