Lack of vitamin E cytoprotective effects on indomethacin-induced gastric lesions.
The ability of vitamin E to protect the gastric mucosa from the ulcerogenic effect of indomethacin was assessed in male rats. A single administration of vitamin E to rats increased levels of vitamin E in fundus (80%), antrum (130%), duodenum (450%), liver (450%), and plasma (230%) in comparison to vehicle treated rats. Oral administration of 30 mg/kg indomethacin to rats previously treated with vitamin E (100 mg/kg), vitamin E-stripped corn oil (vehicle), or to sham pretreated rats induced similar cumulative length and score of gastric lesions in the three groups of animals. These results suggest that, if vitamin E functions as a chain breaking antioxidant, lipid peroxidation is not involved in the pathogenesis of acute gastric mucosal injury caused by indomethacin.
Zaror-Behrens
G
G
Bureau of Human Prescription Drugs, GEHO Division, Ontario, Ottawa, Canada.
Mueller
R
R
Greselin
E
E
Behrens
W A
WA
D000818:Animals; D004386:Duodenum / Q000737:chemistry; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D007213:Indomethacin / Q000378:metabolism / Q000633:toxicity*; D008099:Liver / Q000737:chemistry; D008297:Male; D010084:Oxidation-Reduction; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000737:chemistry; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology; D014810:Vitamin E / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*
D014810:Vitamin E; D007213:Indomethacin