Can ibuprofen cause acute renal failure in a normal individual? A case of acute overdose.
The nonsteroidal antiinflammatory drug (NSAID), ibuprofen, is associated with several renal syndromes, including acute renal failure. NSAID-induced acute renal insufficiency is thought to occur almost exclusively in clinical situations where maintenance of renal blood flow (RBF) is prostaglandin-dependent. However, we present a case of acute renal failure with tubular necrosis occurring as the apparent result of ibuprofen overdose in a patient with no predisposition to NSAID-induced renal failure.
Perazella
M A
MA
Yale-Waterbury Primary Care Residency Program, St. Mary's Hospital, Waterbury, CT.
Buller
G K
GK
D062787:Drug Overdose; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000506:poisoning*; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced* / Q000652:urine; D008875:Middle Aged; D014556:Urine / Q000166:cytology
D007052:Ibuprofen