title: Changes in vertebral bone density in black girls and white girls during childhood and puberty.
abstract: BACKGROUND
  The prevalence of osteoporosis and the incidence of vertebral fractures are lower in black women than in white women, findings generally attributed to racial differences in adult bone mass. Little is known, however, about the factors that contribute to racial variations in bone mass or the time of life when such differences become manifest. This study was done to characterize the changes in vertebral bone density at various stages of sexual development in black and white females.
  
  
  METHODS
  We measured cancellous vertebral bone density by quantitative computed tomography in 75 black female subjects between 2 and 20 years old and 75 whites matched for age and stage of sexual development.
  
  
  RESULTS
  The vertebral bone density did not differ between black girls and white girls before puberty. Bone density increased during puberty in each racial group, but the magnitude of the increase from prepubertal values was substantially greater in black than in white subjects (34 percent vs. 11 percent).
  
  
  CONCLUSIONS
  The marked difference between black and white females in cancellous vertebral bone density occurs during a relatively brief period late in puberty. Metabolic and hormonal events related to the achievement of sexual maturity during adolescence may be important determinants of racial differences in bone mass in women.
authors.affiliation: Department of Radiology, Children's Hospital of Los Angeles 90027.
authors.forename: V
authors.initials: V
authors.lastname: Gilsanz
authors.forename: T F
authors.initials: TF
authors.lastname: Roe
authors.forename: S
authors.initials: S
authors.lastname: Mora
authors.forename: G
authors.initials: G
authors.lastname: Costin
authors.forename: W G
authors.initials: WG
authors.lastname: Goodman
mesh_terms: D000293:Adolescent; D000328:Adult; D044383:Black People; D015519:Bone Density / Q000235:genetics* / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000737:chemistry; D011627:Puberty / Q000502:physiology*; D012741:Sexual Maturation / Q000502:physiology; D044465:White People