title: [Sclerosis of the great saphenous vein: an experimental study in humans of the sclerosing effect of an iodo-iodide solution and polidodecane (histology and electron microscopy)].
abstract: The authors describe an experimental study in man, using electron microscopy to study the effect of sclerosing injections on the great saphenous vein, in particular concerning the initial phases of the process. Results may be summarised as follows: The endothelial lesion develops immediately and is visible only by electron microscopy during the first 15 minutes. It involves necrotic changes with subendothelial edema and, finally, detachment of the endothelial cells. This process is complete on average 2 hours and 30 minutes after the injection. The first deposits of fibrin, which are not abundant, englobe blood cells and loosen already within the first 15 minutes. The first lamellar platelet microclot forms on average 2 hours and a half after the injection but this involves a microclot and not a thrombosis which will become organised. The first massive thrombosis seen occurred between the second and third day after injection and involved a recent thrombus.
authors.affiliation: Cattedra ed Unità Operativa di Chirurgia d'Urgenza, Universita' degli studi di SIENA.
authors.forename: S
authors.initials: S
authors.lastname: Mancini
authors.forename: F
authors.initials: F
authors.lastname: Lassueur
authors.forename: F
authors.initials: F
authors.lastname: Mariani
mesh_terms: D001592:Benzyl Alcohols / Q000008:administration & dosage / Q000627:therapeutic use*; D003902:Detergents / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D004730:Endothelium, Vascular / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007454:Iodides / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008854:Microscopy, Electron; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000627:therapeutic use*; D012501:Saphenous Vein / Q000473:pathology* / Q000648:ultrastructure; D012597:Sclerosing Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D015911:Sclerotherapy / Q000379:methods*; D012964:Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D013927:Thrombosis / Q000473:pathology; D014648:Varicose Veins / Q000628:therapy*
chemical_list: D001592:Benzyl Alcohols; D003902:Detergents; D004338:Drug Combinations; D007454:Iodides; D012597:Sclerosing Solutions; C053468:Varigloban; D000077423:Polidocanol; D011092:Polyethylene Glycols; D012964:Sodium
vernacular_title: La sclérose de la veine grande saphène: étude expérimentale chez l'homme sur l'action sclérosante de la solution iodo-iodurée et le polidodécane (histologie et microscopie électronique).