A reinvestigation of the reaction of desferrioxamine with superoxide radicals. A pulse radiolysis study.
The reaction of desferrioxamine with superoxide has been studied using the pulse radiolysis technique. The decay of O2- was not accelerated in the presence of up to 4 x 10(-4) M desferrioxamine at physiological pH. The rate constant was found to be lower than 2 x 10(4) M-1s-1. In acid solutions the rate constant of the reaction between desferrioxamine and HO'2 was found to be lower than 10(5) M-1s-1. The reaction was not studied in alkaline solutions due to the high absorbance of desferrioxamine in the U.V. region. The pK of desferrioxamine was determined to be 9.2 +/- 0.05.
Goldstein
S
S
Department of Physical Chemistry, Hebrew University of Jerusalem, Israel.
Czapski
G
G
D003676:Deferoxamine / Q000737:chemistry*; D004492:Edetic Acid / Q000494:pharmacology; D005609:Free Radicals; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D011675:Pulse Radiolysis; D012996:Solutions; D013053:Spectrophotometry; D013481:Superoxides / Q000737:chemistry*
D005609:Free Radicals; D012996:Solutions; D013481:Superoxides; D004492:Edetic Acid; D003676:Deferoxamine