Accumulation of 3-hydroxy-L-kynurenine sulfate and ethanolamine in urine of the rat injected with 1-aminoproline.
By intraperitoneal injection of 1-amino-L-proline, a vitamin B6 antagonist, two unidentified ninhydrin-positive compounds were excreted abnormally in rat urine. One of them was definitely identified as 3-hydroxy-L-kynurenine sulfate by chromatographic and spectroscopic analyses. The other was proved to be ethanolamine. This is the first report on the abnormal excretion of ethanolamine in urine of the vitamin B6-deficient rats.
Kimoto
M
M
Department of Nutrition, School of Medicine, University of Tokushima, Japan.
Ogawa
T
T
Sasaoka
K
K
D000818:Animals; D019856:Ethanolamine; D004983:Ethanolamines / Q000652:urine*; D007737:Kynurenine / Q000031:analogs & derivatives* / Q000652:urine; D008297:Male; D011392:Proline / Q000031:analogs & derivatives / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D026681:Vitamin B 6 Deficiency / Q000139:chemically induced / Q000652:urine
D004983:Ethanolamines; C005045:3-hydroxykynurenine; D007737:Kynurenine; D019856:Ethanolamine; C012179:1-aminoproline; D011392:Proline