title: Recovery-phase patterns of ST segment depression in the heart rate domain cannot distinguish between anginal patients with coronary artery disease and patients with syndrome X.
abstract: Continuous plots of ST segment depression related to heart rate during exercise and recovery (heart rate recovery loops) can differentiate patients with coronary artery disease from clinically normal subjects. To assess whether this method can also distinguish patients with angina and coronary artery disease from those with syndrome X (angina, positive exercise tests, and normal coronary arteries), we studied 75 patients with coronary artery disease and 30 patients with syndrome X. The average heart rate recovery loops for coronary artery disease and syndrome X patients followed similar counterclockwise loop rotations. Individual data analysis, however, showed that in coronary artery disease patients the loop rotation was counterclockwise in 66 (88%) and intermediate in nine (12%), while none had a clockwise loop nine (30%), and intermediate in nine (30%). Thus heart rate recovery loops cannot distinguish patients with angina and coronary artery disease from those with syndrome X.
authors.affiliation: Cardiovascular Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
authors.forename: S
authors.initials: S
authors.lastname: Gavrielides
authors.forename: J C
authors.initials: JC
authors.lastname: Kaski
authors.forename: A R
authors.initials: AR
authors.lastname: Galassi
authors.forename: D R
authors.initials: DR
authors.lastname: Hackett
authors.forename: D
authors.initials: D
authors.lastname: Tousoulis
authors.forename: P W
authors.initials: PW
authors.lastname: Burton
authors.forename: A
authors.initials: A
authors.lastname: Maseri
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000175:diagnosis* / Q000503:physiopathology; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D003329:Coronary Vasospasm / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion