title: Results of radiotherapy in patients with stage I orbital non-Hodgkin's lymphoma.
abstract: This paper describes the results of radiotherapy in early stage orbital non-Hodgkin's lymphoma. From 1970 to 1985, 33 orbital localizations in 30 patients were treated. The total dose applied ranged from 21 to 57 Gy (2 Gy per fraction), two-thirds of all patients received a dose of 40 Gy. The complete-response rate was 94% and the 10 years actuarial survival was 90%; no significant difference in survival was observed between patients with low grade or intermediate grade lymphoma. No local recurrence was detected during follow up and 20% of the patients developed generalized disease. Two optic nerve neuropathies and three retinopathies were observed in five patients, four of these occurred at a dose level of less than 43 Gy. Keratitis occurred in 58% of the patients treated, a sicca syndrome in 30% and cataract of different grades in 58% of the patients treated. Although local control was excellent, severe complications were observed in 13% of the patients who received a dose of less than 43 Gy.
authors.affiliation: Department of Radiotherapy, Academisch Medisch Centrum, Amsterdam, The Netherlands.
authors.forename: J G
authors.initials: JG
authors.lastname: Letschert
authors.forename: D
authors.initials: D
authors.lastname: González González
authors.forename: J
authors.initials: J
authors.lastname: Oskam
authors.forename: L
authors.initials: L
authors.lastname: Koornneef
authors.forename: J D
authors.initials: JD
authors.lastname: van Dijk
authors.forename: R
authors.initials: R
authors.lastname: Boukes
authors.forename: J
authors.initials: J
authors.lastname: Bras
authors.forename: P
authors.initials: P
authors.lastname: van Heerde
authors.forename: H
authors.initials: H
authors.lastname: Bartelink
mesh_terms: D004307:Dose-Response Relationship, Radiation; D005123:Eye / Q000528:radiation effects; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D009915:Orbit / Q000528:radiation effects; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed