2-Deoxy-D-glucose (2-DG)-induced increase in gastric acid secretion is impaired in capsaicin-pretreated rats.
This study investigated the increase in gastric acid secretion induced by intravenous administration of 2-deoxy-D-glucose (2-DG; 60 mg kg-1), insulin (5 U kg-1) or by electrical stimulation of the vagus nerve (1 mA, 1 ms, 3 Hz) in urethane-anesthetized rats pretreated when newborn with either capsaicin or the vehicle. The secretory response to 2-DG was substantially reduced in the capsaicin pretreated rats, while those induced by electrical vagal stimulation or insulin were unaffected. These findings suggest that capsaicin-sensitive fibers are involved in the afferent branch of the reflex response activated by 2-DG to stimulate gastric acid secretion.
Evangelista
S
S
Pharmacology Department, Menarini Pharmaceuticals, Florence, Italy.
Santicioli
P
P
Maggi
C A
CA
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000502:physiology
D007328:Insulin; D003847:Deoxyglucose; D002211:Capsaicin