[Therapeutic effects of 9 antitumor drugs on stomach adenocarcinoma (MKN-28) in nude mice].
Therapeutic effects of 9 antitumor drugs were studied on nude mice inoculated with transplanted human stomach tumor (MKN-28). When cisplatin, cyclophosphamide, chlormethine, 5-fluorouracil or mitomycin C was given ip to nude mice bearing MKN-28 at respective dose of 3, 100, 40, 80 and 2 mg/kg once weekly for 3 wk, the tumor inhibition rates of the former 3 drugs were over 80%, while the later 2 were 70-77%. Cytarabine 200 mg/kg twice or thrice weekly for 3 wk gave an inhibition rate of 68-72%. Hydroxycamptothecin 20 mg/kg twice weekly for 3 wk showed a better therapeutic effect than that given at 40 mg/kg once weekly for 3 wk, the tumor inhibition rates were 65 and 32% respectively. No apparent effect of vincristine and methotrexate on MKN-28 was seen. Histopathological observation indicated that in cisplatin group, numerous necrotic areas of tumor cells as well as sparse infiltration of inflammatory cells were found.
Chen
L J
LJ
Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Zhang
S Y
SY
Zhang
Z
Z
Shu
Y H
YH
Zhang
J L
JL
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D008466:Mechlorethamine / Q000627:therapeutic use; D051379:Mice; D008819:Mice, Nude; D016685:Mitomycin; D008937:Mitomycins / Q000627:therapeutic use; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D008937:Mitomycins; D008466:Mechlorethamine; D016685:Mitomycin; D003520:Cyclophosphamide; D002945:Cisplatin; D005472:Fluorouracil