Yohimbine does not affect fat distribution in men.
Forty-seven men with a mean age of 42 years were assigned in random, double-blind fashion to treatment with either placebo or high-dose yohimbine (peak dose, 43 mg/day). Thirty-three subjects completed the six-month program. Variables assessed throughout the study included: body weight and body mass index; total cholesterol and HDL; body fat; and fat distribution as measured both by waist-to-hip ratio and by CT scan. Treatment with yohimbine had no effect on any variable in comparison with the control group.
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Department of Family and Community Medicine, Lancaster General Hospital, PA 17603.
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects*; D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D015992:Body Mass Index; D004311:Double-Blind Method; D006801:Humans; D008066:Lipolysis; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D010349:Patient Compliance; D012885:Skinfold Thickness; D014057:Tomography, X-Ray Computed; D015431:Weight Loss / Q000187:drug effects; D015016:Yohimbine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D015016:Yohimbine