Decrease of inorganic blood sulfate following treatment with selected antirheumatic drugs: potential consequence for articular cartilage.
The elimination kinetics of inorganic blood sulfate in mice was followed for four hours after a single, oral administration of an antirheumatic drug. Sodium salicylate, aspirin, diflunisal and benorylate, all in a dose of 1.25 mmol/kg, reduced the sulfate level to the less than half that of control. This phenomenon was also demonstrated by phenylbutazone, oxyphenbutazone (both 1 mmol/kg), chloroquine diphosphate (0.6 mmol/kg) and tiaprofenic acid (0.02-0.35 mmol/kg). Niflumic acid (1.08 mmol/kg), piroxicam (0.03 mmol/kg), indomethacin (6.10(-3) mmol/kg), diclofenac (5.10(-3) mmol/kg), ketoprofen (0.2 mmol/kg), naproxen (0.08 mmol/kg) and ibuprofen (0.24 mmol/kg) possessed no sulfate lowering properties. The potential relevance of the use of sulfate lowering drugs for articular cartilage integrity is discussed in the light of what is already known about this subject.
de Vries
B J
BJ
Department of Rheumatology, Academic Hospital Sint Radboud, Nijmegen, The Netherlands.
van der Kraan
P M
PM
van den Berg
W B
WB
D000328:Adult; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D002358:Cartilage, Articular / Q000187:drug effects*; D002738:Chloroquine / Q000031:analogs & derivatives / Q000494:pharmacology; D004061:Diflunisal / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010113:Oxyphenbutazone / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011422:Propionates / Q000494:pharmacology; D012459:Salicylates / Q000494:pharmacology; D012980:Sodium Salicylate / Q000494:pharmacology; D013431:Sulfates / Q000097:blood*
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D012459:Salicylates; D013431:Sulfates; C021270:tiaprofenic acid; C023676:chloroquine diphosphate; D004061:Diflunisal; D002738:Chloroquine; D010653:Phenylbutazone; D010113:Oxyphenbutazone; D001241:Aspirin; D012980:Sodium Salicylate