[Effect of menstrual cycle hormones on cation transport in the red-cell membrane].
Erythrocyte cation transport, plasma prorenin and renin and sexual hormones were sequentially evaluated in 12 normal volunteers over the menstrual cycle. Na-K cotransport and Na-Li countertransport raised in 6 out of 12 subjects in synchronization with the ovulatory phase. When the maximal % variation (ovulatory phase) versus baseline (follicular phase) of the Na-K cotransport was plotted versus the maximal % increment of oestrogens. A direct, highly significant inverse correlation was observed (r = 0.904, p less than 0.001). Moreover, a highly significant inverse correlation between plasma prorenin and intraerythrocyte Na (r = -0.857, p less than 0.001) in the follicular phase was found. Our data suggest that erythrocyte cation transport can be influenced by sexual hormones in human.
Melis
M G
MG
Centro Ipertensione, Clinica Medica, Università di Sassari.
Troffa
C
C
Manunta
P
P
Pinna Parpaglia
P
P
Soro
A
A
Pala
F
F
Madeddu
P
P
Pazzola
A
A
Tonolo
G
G
Patteri
G
G
D000328:Adult; D001692:Biological Transport / Q000187:drug effects; D004792:Enzyme Precursors / Q000097:blood; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008094:Lithium / Q000378:metabolism*; D008597:Menstrual Cycle / Q000502:physiology*; D011188:Potassium / Q000378:metabolism*; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D004792:Enzyme Precursors; D012739:Gonadal Steroid Hormones; D008094:Lithium; D012964:Sodium; D012083:Renin; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium
Influenze degli ormoni del ciclo mestruale sui trasporti cationici di membrana dei globuli rossi.