Thyroglobulin in patients with differentiated thyroid carcinoma.
Thyroglobulin (Tg) is a sensitive marker for detection of metastatic disease in patients who have been operated on for differentiated thyroid carcinoma. A high serum Tg value during thyroxine suppression therapy is indicative of metastatic disease, but the sensitivity is enhanced by the endogenous TSH response occurring when thyroxine medication is withheld. False-negative values before thyroxine withdrawal can be demonstrated in about 20% of the patients in our material. If not all thyroid tissue has been eradicated the interpretation of the serum Tg can be difficult. Tg cannot be used to differentiate benign from malignant disease prior to surgery.
Lindegaard
M W
MW
Department of Nuclear Medicine, Norwegian Radium Hospital, Oslo.
Paus
E
E
D014408:Biomarkers, Tumor / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes; D009362:Neoplasm Metastasis; D011379:Prognosis; D011877:Radionuclide Imaging; D012016:Reference Values; D013954:Thyroglobulin / Q000097:blood*; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013964:Thyroid Neoplasms / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*
D014408:Biomarkers, Tumor; D007457:Iodine Radioisotopes; D013954:Thyroglobulin