Parathyroidectomy in the Lyon hypertensive rat: cardiovascular reactivity and aortic responsiveness.
We have studied the effect of parathyroidectomy on the systolic blood pressure, cardiovascular reactivity and the contractile response of isolated aorta to norepinephrine in the genetically hypertensive Lyon rat strain (LH), parathyroidectomized hypertensive Lyon rats (LH-PTX) and parathyroidectomized hypertensive Lyon rats given a Ca-enriched diet to re-establish normocalcemia (LH-PTX + Ca). Parathyroidectomy significantly lessened (-20%) the development of elevated blood pressure. In the LH-PTX + Ca, the blood pressure was lower than that of LH controls but was higher than that of LH-PTX. At 23 weeks, in vivo responsiveness to norepinephrine and angiotensin II was significantly lower in the LH-PTX and only slightly decreased in the LH-PTX + Ca. In contrast, at the same age, the in vitro contractile response of isolated aortas to norepinephrine was significantly higher in the LH-PTX compared with other groups. Interestingly, without endothelium, this difference disappeared. In conclusion, parathyroidectomy lessened the blood pressure elevation in the Lyon model of hypertensive rats via mechanisms that are partly independent of serum calcium levels.
Pernot
F
F
CNRS UA 600, Université Louis Pasteur, Strasbourg, France.
Schleiffer
R
R
Vincent
M
M
Sassard
J
J
Gairard
A
A
D000818:Animals; D001013:Aorta, Thoracic; D001794:Blood Pressure / Q000502:physiology*; D002136:Calcium, Dietary / Q000008:administration & dosage; D004730:Endothelium, Vascular / Q000502:physiology; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D010280:Parathyroid Glands / Q000502:physiology*; D016105:Parathyroidectomy; D051381:Rats; D011918:Rats, Inbred SHR
D002136:Calcium, Dietary; D009638:Norepinephrine