Newly detected endogenous substances: their physiological implications on food intake.
Feeding behavior in mammals is regulated by reciprocal interaction of the LHA and VMH in association with neural macrocircuits including the extrapyramidal, limbic, motor cortex, association cortex and other systems. Some chemoneurons in discrete hypothalamic loci that are related to feeding respond to chemical substances carried mainly in the blood. Among those chemicals, structurally different, endogenous organic acid y lactones, in addition to blood-born glucose analogues and hypothalamic neuronal histamine, are important in feeding modulation by conveying intrinsic satiety and hunger signals with different potency to the neurons in the hypothalamus.
Sakata
T
T
Department of Internal Medicine I, Faculty of Medicine, Kuyushu University, Fukuoka.
D000818:Animals; D001069:Appetite Regulation / Q000502:physiology*; D001786:Blood Glucose / Q000032:analysis; D004435:Eating; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D007276:Injections, Intraventricular; D007328:Insulin / Q000097:blood; D007783:Lactones / Q000008:administration & dosage* / Q000097:blood; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D007783:Lactones