Comparison of flunixin meglumine and flurbiprofen for control of ocular irritative response in dogs.
Dogs were treated with the cyclo-oxygenase inhibitors flunixin meglumine IV or flurbiprofen topically. Acute inflammation was induced in the eyes by disruption of the anterior lens capsule, using a neodymium:yttrium aluminum garnet laser. Pupil diameter and intraocular pressure were measured before and after inducing ocular inflammation. Both drugs maintained mydriasis and increased intraocular pressure in the inflamed eyes, compared with untreated controls.
Millichamp
N J
NJ
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Dziezyc
J
J
D000818:Animals; D003002:Clonixin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D009877:Endophthalmitis / Q000188:drug therapy / Q000662:veterinary*; D005480:Flurbiprofen / Q000494:pharmacology / Q000627:therapeutic use*; D007429:Intraocular Pressure / Q000187:drug effects; D007834:Lasers; D011680:Pupil / Q000187:drug effects
D005480:Flurbiprofen; C014558:flunixin meglumine; D003002:Clonixin