Altered gene expression and oncogenesis of B-cell neoplasia.
B-cell malignancies reveal a number of consistent translocations involving the C-MYC, BCL and IG genes. In common, these rearrangements usually lead to an inability of the involved B-cells to respond to normal regulatory controls for expression of the genes. This usually lead to over-production of the protein products of the genes at inappropriate times of the cell growth cycle and appears to allow a survival advantage to the B-cell. The result of these changes almost certainly plays a prominent role in the development of B-cell neoplasia. Classification of these lymphoma's at a molecular level may be of benefit to determine the prognosis and treatment in addition to providing a useful marker of disease. Determining the molecular basis of these B-cell lymphomas may help our understanding of their pathogenesis. This in turn could lead to more rational treatment aimed at altering the abnormal molecular changes and returning the neoplastic cells to normal cell development.
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ICRF Department of Medical Oncology, St. Bartholomew's Hospital, London, United Kingdom.
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D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D005803:Genes, Immunoglobulin / Q000235:genetics; D016259:Genes, myc / Q000235:genetics; D006801:Humans; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000235:genetics; D008957:Models, Genetic; D009857:Oncogenes / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics