Individualization of theophylline dosage: a Bayesian method evaluated in patients with once-daily dosing.
A Bayesian drug dosing program was prospectively evaluated in 16 hospitalized patients with obstructive respiratory disease treated with a novel sustained-release preparation Euphylong. Theophylline was given as a single evening dose. By means of the Bayesian method, the early morning peak was predicted from a steady-state theophylline serum level determined at 8:00 a.m. The prediction errors were in all cases within a clinically acceptable range (mean prediction error +/- standard deviation: -0.2 +/- 1.3 mg/L). The results were compared with predictions based on steady state theophylline serum levels at 8:00 p.m. The prediction errors observed were on average greater than the prediction errors based on the serum levels at 8:00 a.m. (-0.6 +/- 2.5 mg/L). These findings suggest that the Bayesian method is useful for dosage predictions in patients treated once a day with Euphylong.
Martz
W
W
Abteilung Rechtsmedizin, Christian-Albrechts-Universität, Kiel, F.R.G.
Oellerich
M
M
Schnabel
D
D
Sybrecht
G W
GW
D000328:Adult; D000368:Aged; D001499:Bayes Theorem; D002851:Chromatography, High Pressure Liquid; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*
D013806:Theophylline