Monitoring cyanide and thiocyanate concentrations during infusion of sodium nitroprusside in children.
Over a 19-month period, all requests for blood cyanide and/or serum thiocyanate concentrations to the Clinical Laboratory of The Children's Hospital, Boston, were reviewed in order to determine how physicians screen for nitroprusside-related toxicity. During that period, 52 patients receiving nitroprusside were monitored for cyanide and/or thiocyanate toxicity. Overall, there were 62 cyanide and 86 thiocyanate determinations. None of the thiocyanate determinations and five of the cyanide concentrations were within the toxic range as established by the reference laboratory, and no patient displayed signs or symptoms of toxicity which could not also be explained by their underlying illness. Our findings suggest that while physicians are concerned with nitroprusside toxicity in children, there exists no apparent consensus as to how to monitor for this toxicity. The results also indicate that the relationship between blood cyanide or serum thiocyanate concentrations and clinical evidence of toxicity is not straightforward and requires further delineation.
Linakis
J G
JG
Program in Clinical Pharmacology/Toxicology, Children's Hospital, Harvard University, Massachusetts Poison Control System, Boston.
Lacouture
P G
PG
Woolf
A
A
D000293:Adolescent; D001900:Boston; D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols / Q000592:standards*; D003486:Cyanides / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods / Q000592:standards* / Q000706:statistics & numerical data; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D008485:Medical Audit; D009599:Nitroprusside / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D010818:Practice Patterns, Physicians' / Q000592:standards* / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013861:Thiocyanates / Q000097:blood*
D003486:Cyanides; D013861:Thiocyanates; D009599:Nitroprusside; C031760:thiocyanate