title: Differential effects of an early housing manipulation on cocaine-induced activity and self-administration in laboratory rats.
abstract: Several reports in the literature suggested that environmental influences which are reflected in the social housing conditions of the rat may play a role in the expression of individual differences in drug self-administration. The present experiments were performed in order to further examine the effects of early housing manipulations, as reflected by grouped or isolation housing, on cocaine-induced behavioral responding. The first study examined the effects of this manipulation on the locomotor stimulant properties of cocaine. The results suggested that grouped housing produced a significantly greater increase in cocaine-induced locomotion than was observed in animals housed in isolation. Experiment 2 examined the effects of housing manipulations on the self-administration of cocaine under a continuous reinforcement schedule. Differences in the rate of cocaine self-administration were only observed at the lowest dose tested. Responding at all other doses was equivalent, including the optimal dose for both groups, suggesting that the housing manipulations failed to affect the reinforcing efficacy of cocaine. The present investigation suggests that, while the early housing manipulation produced a differential sensitivity in rats to the stimulant properties of cocaine, the same manipulation failed to alter the sensitivity of rats to the reinforcing properties of cocaine as assessed through self-administration.
authors.affiliation: Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec.
authors.forename: A E
authors.initials: AE
authors.lastname: Boyle
authors.forename: K
authors.initials: K
authors.lastname: Gill
authors.forename: B R
authors.initials: BR
authors.lastname: Smith
authors.forename: Z
authors.initials: Z
authors.lastname: Amit
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006799:Housing, Animal; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012055:Reinforcement Schedule; D012646:Self Administration; D012934:Social Isolation; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D003042:Cocaine