[Data on methods in methacholine inhalation provocation tests (dose-response relationship)].
The cholinergic agonist Methacholine is widely used in unspecific inhalation provocation tests. The maximum changes in lung function take place within two minutes after inhalation. The following spontaneous regression of bronchoconstriction to baseline is prolonged. Therefore, cumulative dose response curves are possible to do. The results of those tests are very dependent on the methods used. Strict standardization of the individual method is necessary. One possible inhalation provocation technique is described.
Schlegel
J
J
III. Med. Klinik-Schwerpunkt Pneumologie, Univ.-Klinik Mainz.
D001249:Asthma / Q000175:diagnosis*; D001985:Bronchial Provocation Tests / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008688:Methacholine Compounds / Q000008:administration & dosage
D008688:Methacholine Compounds
Methodische Daten zum inhalativen Methacholin-Provokationstest (Dosis-Wirkungsbeziehung).