title: Requirement for phosphorylation and localization of the Bicaudal-D protein in Drosophila oocyte differentiation.
abstract: In the Drosophila female the product of the germline stem cell, the cystoblast, gives rise to 16 interconnected cystocytes. One of them differentiates into the oocyte, while the 15 others become polyploid nurse cells. Bic-D is required for the differentiation of an oocyte and hence for fertility. Recessive mutations in Bic-D block the oocyte-specific accumulation of its own and other RNAs. Based on its properties and distribution, the Bic-D protein appears to be a component of a cytoskeletal transport or anchoring system. Additional results suggest that the phosphorylation of the Bic-D protein is essential for its accumulation in the pro-oocyte and that this process leads to the gradual localization to the pro-oocyte of factors required for oocyte differentiation.
authors.affiliation: Department of Molecular Biology, Princeton University, New Jersey 08544.
authors.forename: B
authors.initials: B
authors.lastname: Suter
authors.forename: R
authors.initials: R
authors.lastname: Steward
mesh_terms: D000483:Alleles; D000818:Animals; D000911:Antibodies, Monoclonal; D002454:Cell Differentiation; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D005260:Female; D005808:Genes, Recessive; D016153:Genes, Suppressor; D015151:Immunoblotting; D007301:Insect Hormones / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D009865:Oocytes / Q000166:cytology* / Q000502:physiology; D010766:Phosphorylation
chemical_list: D000911:Antibodies, Monoclonal; C061998:BicD protein, Drosophila; D029721:Drosophila Proteins; D007301:Insect Hormones