Study of a dose-dependent effect of the glycosaminoglycan polysulfate on various parameters of blood coagulation.
In a double-blind study the dose-dependent effect of 10, 20, 40, and 70 mg of SSHA was tested in volunteers. Whereas only a minor prolongation of the aPTT was noted, a clear anti-factor Xa effect was proven (method of Yin), as well as the release of lipoprotein lipase. In a subsequent study, 12 volunteers were treated daily with a dose of 40 mg for 11 days. On the first day of treatment a dosage of 40 mg SC was administered three times every 90 min. There was no cumulative effect with this dose and a clear plateau effect was recorded daily after each application. Repeated administration therefore results in an identical reproducible effect. Thus, no tachyphylaxis occurred under long-term treatment with 40 mg SSHA.
Haas
S
S
Institut für Experimentelle Chirurgie der Technischen Universität München, Germany.
Stemberger
A W
AW
Fritsche
H M
HM
Wendt
P
P
Blümel
G
G
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D002809:Chondroitin Sulfates / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D065427:Factor Xa Inhibitors; D006801:Humans; D007279:Injections, Subcutaneous; D008071:Lipoprotein Lipase / Q000097:blood; D008297:Male
D065427:Factor Xa Inhibitors; C026210:SSHA; D002809:Chondroitin Sulfates; D008071:Lipoprotein Lipase