Creatine kinase isoenzyme BB concentrations in the cerebrospinal fluid of newborns: relationship to short-term outcome.
Creatine kinase brain isoenzyme (CK-BB) was determined in cerebrospinal fluid of 150 neonates by a newly developed immunoenzymatic assay. Newborns with a documented neurologic disorder (intraventricular hemorrhage, postasphyxial encephalopathy, central nervous system infection, or persistent periventricular intraparenchymal echodensities) showed markedly higher concentrations of immunoreactive CK-BB than did the normal newborns or those with subarachnoid hemorrhage. In neonates with seizures the data suggest that the underlying neurologic disorder accounts for the higher CK-BB values and not the seizures per se. High concentrations of CK-BB in the neonatal period were followed by poor short-term outcome.
De Praeter
C
C
Department of Pediatrics, University Hospital, Ghent, Belgium.
Vanhaesebrouck
P
P
Govaert
P
P
Delanghe
J
J
Leroy
J
J
D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000201:enzymology; D002543:Cerebral Hemorrhage / Q000134:cerebrospinal fluid / Q000201:enzymology; D003402:Creatine Kinase / Q000134:cerebrospinal fluid*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D007527:Isoenzymes / Q000134:cerebrospinal fluid*; D008297:Male; D011379:Prognosis
D007527:Isoenzymes; D003402:Creatine Kinase