title: A molecular genetic linkage map of mouse chromosome 2.
abstract: Interspecific backcross mice were used to create a molecular genetic linkage map of chromosome 2. Genomic DNAs from N2 progeny were subjected to Southern blot analysis using molecular probes that identified the Abl, Acra, Ass, C5, Cas-1, Fshb, Gcg, Hox-5.1, Jgf-1, Kras-3, Ltk, Pax-1, Prn-p, and Spna-2 loci; these loci were added to the 11 loci previously mapped to the distal region of chromosome 2 in the same interspecific backcross to generate a composite multilocus linkage map. Several loci mapped near, and may be the same as, known mutations. Comparisons between the mouse and the human genomes indicate that mouse chromosome 2 contains regions homologous to at least six human chromosomes. Mouse models for human diseases are discussed.
authors.affiliation: Mammalian Genetics Laboratory, NCI-Frederick Cancer Research Facility, Maryland 21701.
authors.forename: L D
authors.initials: LD
authors.lastname: Siracusa
authors.forename: C M
authors.initials: CM
authors.lastname: Silan
authors.forename: M J
authors.initials: MJ
authors.lastname: Justice
authors.forename: J A
authors.initials: JA
authors.lastname: Mercer
authors.forename: A R
authors.initials: AR
authors.lastname: Bauskin
authors.forename: Y
authors.initials: Y
authors.lastname: Ben-Neriah
authors.forename: D
authors.initials: D
authors.lastname: Duboule
authors.forename: N D
authors.initials: ND
authors.lastname: Hastie
authors.forename: N G
authors.initials: NG
authors.lastname: Copeland
authors.forename: N A
authors.initials: NA
authors.lastname: Jenkins
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D008817:Mice, Mutant Strains / Q000235:genetics; D009115:Muridae / Q000235:genetics*; D009857:Oncogenes; D012150:Polymorphism, Restriction Fragment Length; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity