Subcorneal pustular dermatosis and IgA paraproteinaemia: response to both etretinate and PUVA.
A non-insulin dependent male diabetic is reported with subcorneal pustular dermatosis associated with intraepidermal IgA deposits and a benign IgA paraproteinaemia. Treatment with dapsone and etretinate was reasonably effective, but etretinate had to be discontinued due to the development of diffuse idiopathic skeletal hyperostosis. His subcorneal pustular dermatosis subsequently flared and was troublesome for 2 years until he was commenced on PUVA, with excellent response.
Todd
D J
DJ
Department of Dermatology, Royal Victoria Hospital, Belfast, Northern Ireland.
Bingham
E A
EA
Walsh
M
M
Burrows
D
D
D000368:Aged; D003622:Dapsone / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005050:Etretinate / Q000627:therapeutic use; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D008297:Male; D011701:PUVA Therapy; D010265:Paraproteinemias / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D012872:Skin Diseases, Vesiculobullous / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism
D007070:Immunoglobulin A; D005050:Etretinate; D003622:Dapsone