The protective role of humoral neutralizing antibody in the NIH potency test for rabies vaccines.
Intraperitoneal vaccination of mice with rabies vaccine results in both dosage-dependent rabies virus neutralizing antibody titres and protection from lethal intracerebral (i.c.) challenge with fixed strain CVS rabies virus. Pre-exposure adoptive intravenous transfer of naive or immune cells did not significantly protect naive Balb/c mice from lethal i.c. CVS challenge, but immune serum and anti-rabies glycoprotein monoclonal antibodies (individually and in combination) did confer significant protection when administered before or up to 24 h after lethal i.c. rabies virus challenge.
Wunderli
P S
PS
Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta, GA 30333.
Shaddock
J H
JH
Schmid
D S
DS
Miller
T J
TJ
Baer
G M
GM
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology*; D005260:Female; D016219:Immunotherapy, Adoptive; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D011819:Rabies Vaccines / Q000276:immunology*; D014611:Vaccination
D000914:Antibodies, Viral; D011819:Rabies Vaccines