Effects of single dose irradiation on pancreatic beta-cell function.
We have irradiated abdominal cavity of 23 rats with 10 Gy irradiation-induced hypoglycemia on the fourth day after intervention. Islets collected at this time showed an impaired insulin secretion without affecting insulin content. This impairment persisted after one month follow-up with reduced number of beta-cells in morphological examination.
Sarri
Y
Y
Endocrinology and Diabetes Unit, School of Medicine, Barcelona University, Spain.
Conill
C
C
Verger
E
E
Tomas
C
C
Gomis
R
R
D000005:Abdomen / Q000528:radiation effects; D000230:Adenocarcinoma / Q000532:radiotherapy*; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007515:Islets of Langerhans / Q000528:radiation effects*; D010179:Pancreas / Q000528:radiation effects; D010190:Pancreatic Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology; D011833:Radiation Injuries, Experimental; D011879:Radiotherapy Dosage; D051381:Rats