Micronucleated lymphocytes in people occupationally exposed to potential environmental contaminants: the age effect.
This work is part of a research project on 2 groups of tannery workers (i.e., workers employed in the tanning process and those employed in the finishing department), and 2 control groups consisting of individuals paired with each exposed person according to sex, age and smoking habit. The whole study included the evaluation of micronuclei as well as of chromosomal aberrations and sister-chromatid exchanges in peripheral blood lymphocytes. Data on micronucleus analysis in both controls and exposed persons are shown in this paper. There was no statistically significant difference between MN frequencies in the 2 groups of exposed and controls, nor any positive correlation with smoking habit. The effect of age on basal frequency of micronucleated cells clearly emerges in the present study: both controls and exposed show an increase in MN frequency due to age. This could be correlated with a higher sensitivity to breaks, rearrangements or aneuploidogenic events of circulating lymphocytes in aged people.
Migliore
L
L
Dipartimento di Scienze dell'Ambiente e del Territorio, Università di Pisa, Italy.
Parrini
M
M
Sbrana
I
I
Biagini
C
C
Battaglia
A
A
Loprieno
N
N
D000328:Adult; D000375:Aging / Q000097:blood / Q000235:genetics*; D002869:Chromosome Aberrations; D004785:Environmental Pollutants / Q000097:blood; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000473:pathology; D015162:Micronucleus Tests; D008875:Middle Aged; D016273:Occupational Exposure; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000097:blood / Q000235:genetics; D013633:Tanning
D004785:Environmental Pollutants