[Amplifying sequences in the Streptomyces coelicolor A3 (2) gene].
The unstable feature of ristomycin resistance in S. coelicolor A3 (2) was studied. It was shown that the frequency of ristomycin-resistant derivatives was high in both chloramphenicol sensitive mutants and their resistant revertants. The 15- and 20-kb DNA sequences capable of amplifying were detected in the chloramphenicol resistant revertants. In the genomes of the studied strains they were represented by 50 and 40 copies, respectively.
Zavorotnaia
S A
SA
Fedorenko
V A
VA
Starodubtseva
L I
LI
Danilenko
V N
VN
D002701:Chloramphenicol / Q000494:pharmacology; D002702:Chloramphenicol Resistance / Q000235:genetics; D003470:Culture Media; D004269:DNA, Bacterial / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics; D005784:Gene Amplification / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics*; D066298:In Vitro Techniques; D009154:Mutation / Q000235:genetics*; D012310:Ristocetin / Q000494:pharmacology; D013302:Streptomyces / Q000187:drug effects / Q000235:genetics*
D003470:Culture Media; D004269:DNA, Bacterial; D012310:Ristocetin; D002701:Chloramphenicol
Amplifitsiruiushchiesia posledovatel'nosti v genome Streptomyces coelicolor A3 (2).