Aldehyde reductase is a major protein associated with 3-deoxyglucosone reductase activity in rat, pig and human livers.
3-Deoxyglucosone reductase activity in the extracts of rat, pig and human livers was potently inhibited by aldehyde reductase inhibitors. The major species of 3-deoxyglucosone reductase purified from human and pig livers were biochemically and immunochemically identical with aldehyde reductase. The two enzymes and rat liver aldehyde reductase exhibited higher catalytic efficiency for 3-deoxyglucosone than for D-glucuronate, a representative substrate of aldehyde reductase.
Kanazu
T
T
Department of Biochemistry, Gifu Pharmaceutical University, Japan.
Shinoda
M
M
Nakayama
T
T
Deyashiki
Y
Y
Hara
A
A
Sawada
H
H
D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000449:Aldehyde Reductase / Q000378:metabolism*; D000818:Animals; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine
D003847:Deoxyglucose; D000429:Alcohol Oxidoreductases; C019642:alcohol dehydrogenase (NADP+); D000449:Aldehyde Reductase; C016350:3-deoxyglucosone