Natural killer (NK) cell activity of mice treated with herpes simplex virus type-2, sarcoma-180 cells, cyclosporine and cimetidine.
NK cell activity in beige mice was compared with that in control BALB/c mice and BALB/c mice treated with HSV-2, sarcoma-180 cells, cimetidine and cyclosporine. The NK cell activity in five week-old beige mice was lower than in three week-old BALB/c mice. The NK cell activity in eight week-old BALB/c mice was four to eleven times the activity in BALB/c mice that were three weeks of age. BALB/c mice, injected with 2 mg cyclosporine or 10(7) plaque forming units (PFU) of HSV-2, had decreased NK cell activity. BALB/c mice, injected with 2 mg cimetidine, 10(6) sarcoma-180 cells and 6.0 x 10(5) PFU of HSV-2, had high NK cell activities compared with the control mice. Cimetidine further increased the effect of HSV-2 or sarcoma-180 on NK activity. BALB/c mice that received a transfer of less than 10(7) NK cells developed a high resistance against viral infections, but mice that received more than 10(7) transferred NK cells had a lower resistance to viral infections than the control mice or mice receiving less than 10(7) NK cells.
Kabuta
H
H
Department of Virology, Kurume University School of Medicine, Japan.
Tanaka
M
M
Noda
Y
Y
Yamamoto
S
S
Shingu
M
M
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D003524:Cyclosporins / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012510:Sarcoma 180 / Q000276:immunology*; D018139:Simplexvirus / Q000276:immunology*; D014407:Tumor Cells, Cultured
D003524:Cyclosporins; D002927:Cimetidine