title: The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators.
abstract: Complex retroviruses, including Human Immunodeficiency Virus Type 1 (HIV-1), are characterized by the ordered temporal expression of the various viral gene products in infected cells. This effect is mediated by a novel class of RNA-sequence-specific regulatory proteins typified by the Rev trans-activator of HIV-1. Evidence suggests that Rev regulates HIV-1 gene expression by intervening in the normal pathway of eukaryotic mRNA processing and transport.
authors.affiliation: Howard Hughes Medical Institute, Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.
authors.forename: B R
authors.initials: BR
authors.lastname: Cullen
authors.forename: M H
authors.initials: MH
authors.lastname: Malim
mesh_terms: D001483:Base Sequence; D015967:Gene Expression Regulation, Viral / Q000235:genetics; D015757:Genes, rev / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D008969:Molecular Sequence Data; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D012333:RNA, Messenger