title: Haemodynamic and metabolic effects of ketanserin in dyslipidaemic hypertensive subjects.
abstract: Eighteen dyslipidaemic patients affected with moderate hypertension were studied before and after short-term treatment with ketanserin (40 mg/die) on hypocaloric (22-25 kcal/kg/die) and normosodic-normopotassic diet. Student's t test applied to the determinations revealed a significant reduction of systolic and diastolic blood pressure (SBP, p less than 0.001, DBP p less than 0.001), total cholesterol (p less than 0.001) and triglycerides (p less than 0.006). The results suggest that ketanserin is an effective hypotensive drug and its association with a hypocaloric diet promotes a decrease in plasma lipids.
authors.affiliation: I Patologia Speciale Medica, University of Rome La Sapienza, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Letizia
authors.forename: M
authors.initials: M
authors.lastname: Sellini
authors.forename: D
authors.initials: D
authors.lastname: Scavo
mesh_terms: D000328:Adult; D000368:Aged; D004038:Diet, Reducing; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007650:Ketanserin / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D008055:Lipids; D007650:Ketanserin