[The role of apoprotein B in the diagnosis and follow up of hyperlipoproteinemias in childhood].
The levels of apoproteins AI, B, lipoproteins (Total-C, LDL-C HDL-C, VLDL-C) and B/AI, LDL-C/HDL-C ratios were analyzed in 41 patients with primary hypercholesterolemia. 25 patients (60%) had a positive family history of hyperlipemia. All the patients showed a "pathological" apo B values, but only 35 of them (85%) coexisted with high Total-C and LDL-C values. 28/41 patients (68%) were treated and followed for more than one year, after which two groups were obtained: Group 1, respondent (N = 15) in which we observed a significant decrease of Total-C and Apo B after diet treatment. Group 2, no respondent (N = 13) in which not change in any biochemical parameter was observed, and required the addition of drug treatment (Probucol). Apoprotein B level was the biochemical parameter, which showed the highest porcentual decrease after treatment, in comparison with other biochemical parameters, resulting in a lowering of 36.3 and 26.3 percent for group 1 and 2 respectively. These results prove the usefulness of Apo B level measurement in the diagnosis of hyperlipoproteinemia in the pediatric age, as well as that children with normal total-C and LDL-C may have pathological Apo B and Apo B level is the parameter with highest decrease with dietetic and/o farmacological treatment.
Montero Brens
C
C
Unidad de Nutrición, Departamento de Pediatría, Hospital Infantil, La Fe, Valencia.
Breto Gilabert
M
M
Dalmau Serra
J
J
D001055:Apolipoproteins B / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000178:diet therapy / Q000188:drug therapy; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D011341:Probucol / Q000627:therapeutic use
D001055:Apolipoproteins B; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D011341:Probucol
Importancia de la apoproteína B en el diagnóstico y seguimiento de las hiperlipoproteinemias en la edad pediátrica.