title: Comparative efficacy of combination fansidar-sulphate quinine and fansidar-chloroquine in mixed malaria infections of P. falciparum-P. vivax in children.
abstract: From January 1987 until March 1990, 61 children suffering from mixed malaria infections of P. falciparum and P. vivax entered the Department of Child Health Medical School Sam Ratulangi University/Gunung Wenang General Hospital, Manado. Only 41 patients were evaluated as 20 patients did not fulfill the inclusion criteria. Twenty patients were treated with fansidar-quinine (Group I), and 21 patients with fansidar chloroquine (Group II). In group II, the asexual form of P. vivax disappeared in 2 days after having been treated with fansidar-chloroquine. Conversely, in group I the asexual form of P. vivax disappeared after 5 days of treatment. Statistical analysis showed a significant difference (p less than 0.001). No significant difference could be detected between the duration of asexual parasitemia of P. falciparum in these two groups (p = 0.3085). No statistically significant difference could be detected concerning the duration of fever and the length of hospitalization between these two groups.
authors.affiliation: Department of Child Health Medical School, Sam Ratulangi University, Gunung Wenang Hospital, Manado, Indonesia.
authors.forename: A
authors.initials: A
authors.lastname: Liando
authors.forename: T H
authors.initials: TH
authors.lastname: Rampengan
mesh_terms: D000293:Adolescent; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use*; D004338:Drug Combinations; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007902:Length of Stay; D016778:Malaria, Falciparum / Q000188:drug therapy*; D016780:Malaria, Vivax / Q000188:drug therapy*; D008297:Male; D011446:Prospective Studies; D011739:Pyrimethamine / Q000627:therapeutic use*; D011803:Quinine / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D002738:Chloroquine; D011803:Quinine; D011739:Pyrimethamine