title: K20 and ICO-10 monoclonal antibodies (gp120/200; Thy-1): immunophenotyping of human solid tumours.
abstract: Solid tumour cells were shown to express VLA-beta and Thy-1 antigens. For identification of these molecules two monoclonal antibodies, K-20 and ICO-10, characterised in detail previously, were used. Four groups of solid tumours have been identified according to their immunophenotype: VLA-beta+ and Thy-1-; VLA-beta+ and Thy-1+; VLA-beta- and Thy-1+; VLA-beta- and Thy-1-. To a certain extent these groups have been shown to reflect tumour histogenesis: tumours of epithelial origin never expressed an ICO-10+, K20-phenotype while soft tissue sarcomas and neuroblastoma cells never expressed the beta-chain of VLA molecular complexes.
authors.affiliation: Laboratory of Clinical Radioimmunology, All-Union Cancer Research Centre of the AMS USSR, Moscow.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Kadagidze
authors.forename: N N
authors.initials: NN
authors.lastname: Tupitsyn
authors.forename: A J
authors.initials: AJ
authors.lastname: Baryshnikov
authors.forename: K P
authors.initials: KP
authors.lastname: Kadyrov
authors.forename: V M
authors.initials: VM
authors.lastname: Blinov
authors.forename: A
authors.initials: A
authors.lastname: Bernard
authors.forename: M
authors.initials: M
authors.lastname: Amiot
authors.forename: L
authors.initials: L
authors.lastname: Boumsell
mesh_terms: D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000276:immunology*; D010641:Phenotype; D016029:Receptors, Very Late Antigen / Q000276:immunology; D018800:Thy-1 Antigens
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000954:Antigens, Surface; D016029:Receptors, Very Late Antigen; D018800:Thy-1 Antigens