[Increase of erythrocyte disaggregation shear rate in arterial hypertension].
Aggregation index and critical disaggregation shear rate (which represent the minimum shear rate necessary to break up the aggregates) have been measured for 21 hypertensive and 17 normotensive subjects by a laser technique (erythro-aggregameter SEFAM). A simultaneous measurement of blood viscosity by a Couette viscometer with coaxial cylinders at different shear rate allowed the calculation of critical disaggregation shear stress by the product of critical disaggregation shear rate and blood viscosity. The comparison of the results of normotensive and hypertensive subjects showed a higher aggregation index (22%, p less than 0.0001), critical disaggregation shear rate (19%, p less than 0.002) and critical disaggregation shear stress (29%, p less than 0.004) in hypertensive patients. These alterations might play an important role on development of cardiovascular complication in hypertensive subjects.
Razavian
S M
SM
Centre de médecine préventive cardiovasculaire, INSERM U28, hôpital Broussais, Paris.
Del-Pino
M
M
Chabanel
A
A
Simon
A
A
Levenson
J
J
D000328:Adult; D001809:Blood Viscosity; D004903:Erythrocyte Aggregation / Q000503:physiopathology; D006400:Hematocrit; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008875:Middle Aged
Augmentation de la contrainte de cisaillement de désagrégation érythrocytaire dans l'hypertension artérielle.