title: Toxicological analysis of a fatal baclofen (Lioresal) ingestion.
abstract: A fatality following ingestion of the drug baclofen (Lioresal) is described. Baclofen was identified in urine by gas chromatography/mass spectrometry. After derivatization with trinitrobenzene sulfonic acid, baclofen was quantitated in serum and urine by high-performance liquid chromatography. The concentration of baclofen was 17 mg/L in serum and 760 mg/L in urine collected approximately 12 h after the overdose. To our knowledge, this is only the second reported fatality involving a baclofen overdose. The previous case did not include quantitation of baclofen in any biological fluid.
authors.affiliation: Toxicology Laboratory, Victoria General Hospital, Nova Scotia, Canada.
authors.forename: A D
authors.initials: AD
authors.lastname: Fraser
authors.forename: W
authors.initials: W
authors.lastname: MacNeil
authors.forename: A F
authors.initials: AF
authors.lastname: Isner
mesh_terms: D000328:Adult; D001418:Baclofen / Q000097:blood / Q000506:poisoning* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D062787:Drug Overdose / Q000473:pathology; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D011782:Quadriplegia / Q000188:drug therapy*
chemical_list: D001418:Baclofen