Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): diagnosis by fine-needle aspiration.
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare idiopathic proliferative disorder of histiocytes with characteristic morphologic features. We describe a case of SHML occurring in a 14-yr-old black male, in whom the diagnosis was made by fine-needle aspiration of a cervical lymph node. Cytologic features included increased numbers of large histiocytes associated with a polymorphous, cellular background composed of benign lymphocytes, plasma cells, and polymorphonuclear leukocytes. Lymphophagocytosis was a prominent feature. Extranodal involvement of the larynx was documented by surgical biopsy; there was no other extranodal disease. One year after diagnosis, the patient is clinically well, with no residual lymphadenopathy.
Trautman
B C
BC
Department of Pathology, Hennepin County Medical Center, Minneapolis, MN 55415.
Stanley
M W
MW
Goding
G S
GS
Rosai
J
J
D000293:Adolescent; D001707:Biopsy, Needle; D015618:Histiocytosis, Sinus / Q000150:complications* / Q000473:pathology*; D006801:Humans; D007818:Laryngeal Diseases / Q000209:etiology* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009333:Neck