[Estrogenization with natural hormones in the treatment of prostatic cancer (experimental research)].
Chemotherapy with synthetic estrogens combined with orchiectomy as a treatment for advanced prostatic cancer (PC) has certain disadvantages, i. e. cardiovascular, coagulative, gastrointestinal complications. To prevent the latter, the authors suggest natural estrogens which may be supplied from a transplanted allogenic ovary. Experiments support feasibility of ovarian tissue adaptation in rat males and its intact functional activity. In rats subjected to the transplantation serum levels of estradiol grew significantly against the intact animals, regression of the glandular component in the prostate was more pronounced compared to sterilized animals without the transplant. It is thought possible to estrogenize the body of the male rats in free transplantation of the ovary combined with sterilization. The results are suggestive of possible clinical effect in PC patients.
Lopatkin
N A
NA
Gaĭbullaev
A A
AA
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000637:transplantation; D011467:Prostate / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D051381:Rats; D013997:Time Factors; D016042:Transplantation, Heterotopic; D014184:Transplantation, Homologous
D004967:Estrogens
Estrogenizatsiia prirodnymi gormonami v lechenii raka predstatel'noĭ zhelezy (éksperimental'noe issledovanie).