Nucleolar organizer regions (NORs) in normal and pathological liver: a quantitative analysis.
By means of a silver staining method, Nucleolar Organizer Region-associated proteins (NORs) have been evaluated on paraffin sections of a series of 58 ultrasound-guided liver biopsy specimens. These included 12 normal livers, 12 cirrhotic livers, 12 cases of chronic hepatitis and 22 cases of hepatocellular carcinoma. A significant difference (P less than 0.001) was found between the mean AgNOR scores of the normal and pathological biopsies, and between the non-neoplastic and the carcinomatous lesions. The authors suggest that AgNOR counts, in combination with conventional histocytological criteria, may be a useful method in the diagnosis of liver diseases.
Anselmi
L
L
Servizio di anatomia patologica, Ospedali Galliera di Genova.
Sementa
A R
AR
Borgiani
L
L
Banderali
A
A
Rovida
S
S
D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008099:Liver / Q000648:ultrastructure*; D008113:Liver Neoplasms / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000473:pathology*