title: Remineralization and demineralization in situ from a triclosan/co-polymer/fluoride dentifrice.
abstract: An in situ study was conducted to evaluate the effect of a dentifrice containing 1100 ppm F (NaF) and triclosan, an anti-plaque agent, on remineralization of artificially-formed caries lesions in thin sections of human enamel. The thin sections were placed in mandibular partial dentures of 15 subjects and covered with a steel mesh to provide an area for plaque accumulation. The subjects brushed their teeth and dentures three times daily for two-week periods in a cross-over design, after which the specimens were removed and analyzed by quantitative microradiography for changes in mineral content. Results showed that lesions treated with the triclosan-fluoride product were remineralized 18.0 +/- 23.4% compared with 19.0 +/- 32.3% from a 1100-ppm F (NaF) positive control. Use of a placebo dentifrice resulted in 71.9% demineralization. The findings showed that triclosan neither enhanced nor interfered with the promotion of remineralization by fluoride.
authors.affiliation: Colgate-Palmolive Company, Technology Center, Piscataway, NJ 08854.
authors.forename: J R
authors.initials: JR
authors.lastname: Mellberg
authors.forename: J
authors.initials: J
authors.lastname: Blake-Haskins
authors.forename: I D
authors.initials: ID
authors.lastname: Petrou
authors.forename: N E
authors.initials: NE
authors.lastname: Grote
mesh_terms: D000328:Adult; D000368:Aged; D003731:Dental Caries / Q000517:prevention & control; D003743:Dental Enamel / Q000187:drug effects*; D003773:Dental Plaque / Q000517:prevention & control; D003802:Dentifrices / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008298:Maleates / Q000494:pharmacology; D008875:Middle Aged; D011145:Polyvinyls / Q000494:pharmacology; D017001:Tooth Demineralization; D014089:Tooth Remineralization; D014260:Triclosan / Q000494:pharmacology*
chemical_list: D003802:Dentifrices; D008298:Maleates; D011145:Polyvinyls; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D014260:Triclosan