[The experimental induction of rheumatoid factors of low affinity and cross reactivity with nonhistone nucleoproteins by means of anti-idiotypes directed at rheumatoid factors of high affinity and cross reactivity with histones H1 and H2b].
The study of the anti-nuclear cross reactivity of rheumatoid factors has shown differences between patients with rheumatoid arthritis and healthy seropositive subjects. This paper describes the finding, of a subpopulation of rheumatoid factor molecules which show a cross reactive idiotype and show high affinity for IgG and cross reactivity against histones in rheumatoid arthritis patients but not in healthy subjects. These molecules, in turn, were able to induce, experimentally, heterogeneous rheumatoid factor molecules that show a low affinity for IgG and cross-reactivity against nucleoproteins other than histones, most likely through idiotypic networks. The mechanism could be responsible for the diversification of serum autoantibodies found in rheumatoid arthritis.
Ruiz-Argüelles
A
A
Departamento de Inmunología, Laboratorios Clínicos de Puebla.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis / Q000276:immunology* / Q000302:isolation & purification; D000915:Antibody Affinity / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D002868:Chromosomal Proteins, Non-Histone / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D005260:Female; D006657:Histones / Q000276:immunology*; D006801:Humans; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D011817:Rabbits; D012217:Rheumatoid Factor / Q000096:biosynthesis* / Q000097:blood / Q000302:isolation & purification
D000888:Antibodies, Anti-Idiotypic; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D012217:Rheumatoid Factor
Inducción experimental de factores reumatoides de baja afinidad y reactividad cruzada con nucleoproteinas no histonas mediante anti-idiotipos dirigidos a factores reumatoides de alta afinidad y reactividad cruzada con histonas H1 y H2b.