title: Synthesis and biological evaluation of N-salicyloyl-N-benzyl thiourea and 2,2-dimethyl-4-oxo-6-methoxy benzo-1,3-dioxin.
abstract: The synthesis of N-salicyloyl-N-benzyl-thiourea and 2,2-dimethyl-4-oxo-6-methoxy-benzo-1,3-dioxin are described. They were studied for their antiviral, antiproliferative and antimicrobial activities in vitro. N-salicyloyl-N-benzyl-thiourea exhibited significant activity against Gram-positive bacteria and against influenza viruses types A/Philippine/H3N2, A/Chilli/H1N1 and B/Paraha, as well as against K562 cell proliferation. By contrast, no such activity was demonstrated by 2,2-dimethyl-4-oxo-6-methoxy-benzo-1,3-dioxin.
authors.affiliation: Department of Biology, College of Education, University of Mosul, Iraq.
authors.forename: L J
authors.initials: LJ
authors.lastname: Rashan
authors.forename: J M
authors.initials: JM
authors.lastname: al-Rawi
authors.forename: M T
authors.initials: MT
authors.lastname: Nadir
authors.forename: L
authors.initials: L
authors.lastname: Awni
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004147:Dioxins / Q000138:chemical synthesis* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D012459:Salicylates / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured; D010948:Viral Plaque Assay; D014780:Viruses / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents; D004147:Dioxins; D012459:Salicylates; C071825:N-salicyloyl-N-benzylthiourea; C071826:2,2-dimethyl-4-oxo-6-methoxybenzo-1,3-dioxin