title: The use of DIN glass ampoules to freeze-dry biological materials with a low residual moisture and oxygen content.
abstract: A capillary device has been developed to enable biological materials to be freeze-dried from aqueous and non-aqueous solution in ampoules conforming to DIN 58377-B5-fl. This device reduced the absorption of atmospheric moisture by the material and the diffusion of oxygen into the ampoules awaiting sealing, by a factor of 13 and 7, respectively, over a 30 min period, respectively, compared to unprotected ampoules. The device has the advantage of being able to be assembled and fitted to the ampoules mechanically.
authors.affiliation: National Institute for Biological Standards and Control, South Mimms, Herts, U.K.
authors.forename: P K
authors.initials: PK
authors.lastname: Phillips
authors.forename: P J
authors.initials: PJ
authors.lastname: Dawson
authors.forename: A J
authors.initials: AJ
authors.lastname: Delderfield
mesh_terms: D001688:Biological Products / Q000032:analysis* / Q000592:standards; D005069:Evaluation Studies as Topic; D005612:Freeze Drying / Q000295:instrumentation*; D005898:Glass; D010100:Oxygen / Q000032:analysis; D012015:Reference Standards; D014867:Water / Q000032:analysis
chemical_list: D001688:Biological Products; D014867:Water; D010100:Oxygen