Flow cytometric DNA histograms of paraffin-embedded pheochromocytomas.
We proposed a new classification of pheochromocytomas according to DNA ploidy patterns. Proliferation index (PI = S% + 4C%) might be an alternative to 4C% which was used as a critical marker of DNA nonaneuploid histograms. The follow-up survey revealed that DNA tetraploid with minimum increase of PI could not rule out the substantial possibility of malignancy and the comparison of DNA diploid histograms disclosed that 22 and 0% showed significant increase of the ratio of 4C% to S% under PI and 4C% criteria, respectively. In conclusion, 4C% was more effective and reliable than PI in order to classify DNA nonaneuploid pheochromocytomas.
Hosaka
Y
Y
Department of Urology, University of Tokyo, Japan.
Aso
Y
Y
Rainwater
L M
LM
Grant
C S
CS
Farrow
G M
GM
van Heerden
J A
JA
Lieber
M M
MM
D000310:Adrenal Gland Neoplasms / Q000145:classification / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D016612:Paraffin Embedding; D010673:Pheochromocytoma / Q000145:classification / Q000235:genetics*; D011003:Ploidies
D004273:DNA, Neoplasm