Control of granulocytes and macrophages: molecular, cellular, and clinical aspects.
The production and functional activity of two important white blood cells, the granulocytes and macrophages, are regulated mainly by a group of glycoprotein colony-stimulating factors. The colony-stimulating factors have been mass-produced with recombinant technology and are now proving of value in preventing or suppressing infections in a variety of individuals with subnormal or defective formation of blood cells.
Metcalf
D
D
Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia.
D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy; D000741:Anemia, Aplastic / Q000628:therapy; D000818:Animals; D003115:Colony-Stimulating Factors / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D006098:Granulocytes / Q000166:cytology / Q000502:physiology*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000502:physiology*; D051379:Mice; D009369:Neoplasms / Q000628:therapy; D009503:Neutropenia / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use
D003115:Colony-Stimulating Factors; D011994:Recombinant Proteins