[The level of thromboxane A2 and prostacyclin in patients with chronic kidney failure undergoing hemodialysis].
Overall 14 patients with chronic renal failure treated by hemodialysis were examined. The content of the key metabolites of the arachidonic cascade thromboxane B2, 6-keto-prostaglandin F1 alpha and 12-hydroxyeicosatetraene acid (12-HETE) in blood plasma was reduced in the patients as compared to donors. By the end of hemodialysis, part of the patients showed a tendency towards its normalization, however, no complete recovery was practically recorded. Derangement of the formation of thromboxane A2, prostacyclin and 12-HETE in uremia is likely to be related to reverse inhibition of the function of platelet cyclooxygenase and lipoxygenase by plasma inhibitor. The recovery of the function can be attained after adequate hemodialysis.
Rud'ko
I A
IA
Kubatiev
A A
AA
Tsalenchuk
Ia P
IaP
Stel'makov
B G
BG
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D011464:Epoprostenol / Q000097:blood*; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008875:Middle Aged; D006435:Renal Dialysis; D013928:Thromboxane A2 / Q000097:blood*; D013929:Thromboxane B2 / Q000097:blood; D014511:Uremia / Q000097:blood / Q000628:therapy
D006893:Hydroxyeicosatetraenoic Acids; D013929:Thromboxane B2; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D011464:Epoprostenol
Soderzhanie tromboksana A2 i prostatsiklina u bol'nykh khronicheskoĭ pochechnoĭ nedostatochnost'iu pri gemodialize.