title: Angiotensin converting enzyme activity in children with congenital heart disease.
abstract: Serum angiotensin converting enzyme (ACE) activity was determined in 46 children with congenital heart disease with normal and abnormal lung perfusion: (1) congenital heart disease with normal pulmonary blood flow (12 patients); (2) congenital heart disease with increased pulmonary blood flow (18 patients); (3) congenital heart disease with decreased pulmonary blood flow (16 patients). There was no significant difference in serum ACE activity between the three groups. In group 2 serum ACE activity had a tendency to correlate inversely with both mean pulmonary arterial pressure (r = -0.43; P less than or equal to 0.05) and pulmonary vascular resistance (r = -0.48; P = 0.05). No further correlations between serum ACE activity and age, serum electrolytes, creatinine nor other haemodynamic data could be established.
authors.affiliation: Department of Paediatrics, University of Vienna, Austria.
authors.forename: U
authors.initials: U
authors.lastname: Salzer-Muhar
authors.forename: W
authors.initials: W
authors.lastname: Graninger
authors.forename: H R
authors.initials: HR
authors.lastname: Salzer
authors.forename: M
authors.initials: M
authors.lastname: Wimmer
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000201:enzymology*; D006801:Humans; D007223:Infant; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D011651:Pulmonary Artery / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D007703:Peptidyl-Dipeptidase A