title: Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes.
abstract: Myogenin is a member of a family of muscle-specific regulatory factors which includes MyoD1, Myf-5, and Myf-6 (also called MRF4 and herculin). Extensive regions of sequence homology in genes for these three factors suggest duplication events associated with their evolution. In the present study, the chromosomal location of the myogenin gene in humans (MYOG), mice (Myog), and Chinese hamsters (MYOG) was determined using in situ hybridization to human metaphase chromosomes as well as segregation analysis among interspecific somatic cell hybrid panels and interspecific backcrossed mice. We localize the gene encoding myogenin to human chromosome 1q31-q41 within a linkage group homologous with a region on mouse chromosome 1 and Chinese hamster chromosome 5. The results verify the nonlinkage of MYOG to MYOD1, MYF5, and MYF6 genes and indicate that events associated with the duplication of MYOG with respect to MYOD1, MYF5, or MYF6 loci were not chromosome-wide.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center, Houston 77030.
authors.forename: E
authors.initials: E
authors.lastname: Olson
authors.forename: D
authors.initials: D
authors.lastname: Edmondson
authors.forename: W E
authors.initials: WE
authors.lastname: Wright
authors.forename: V K
authors.initials: VK
authors.lastname: Lin
authors.forename: J L
authors.initials: JL
authors.lastname: Guenet
authors.forename: D
authors.initials: D
authors.lastname: Simon-Chazottes
authors.forename: L H
authors.initials: LH
authors.lastname: Thompson
authors.forename: R L
authors.initials: RL
authors.lastname: Stallings
authors.forename: W T
authors.initials: WT
authors.lastname: Schroeder
authors.forename: M
authors.initials: M
authors.lastname: Duvic
mesh_terms: D000818:Animals; D002878:Chromosomes, Human, Pair 1; D006224:Cricetinae; D003412:Cricetulus / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells / Q000737:chemistry; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains / Q000235:genetics; D005810:Multigene Family; D009124:Muscle Proteins / Q000235:genetics*; D018008:Myogenin; D010802:Phylogeny
chemical_list: C503799:MYOG protein, human; D009124:Muscle Proteins; C503801:Myog protein, mouse; D018008:Myogenin