title: The transient and cumulative effect of sodium lauryl sulphate on the epidermal barrier assessed by transepidermal water loss: inter-individual variation.
abstract: The aims of the investigation were: 1) to study the inter-individual variation in time course of TransEpidermal Water Loss and of clinical manifestations after a 24-h single exposure to Sodium Lauryl Sulphate. This TEWL time course (expressed as the difference in TEWL between the day of patch removal and a subsequent day) reflected the epidermal barrier response to the damage caused by SLS; 2) to investigate the association between the TEWL time course after the single SLS exposure and the TEWL value after 4-day repeated SLS exposure (as a model for cumulative irritation). The 35 healthy subjects tested could be divided into four sub-groups according to the day of their maximum TEWL value after the single SLS exposure (days 2 to 5). For the whole group, inter-individual variation in TEWL course was most pronounced in the first days following the single SLS application. Moreover, there was an inverse relationship (R = -0.61) between TEWL course during the first days after the single exposure and the TEWL value after 4-day repeated exposures. It is concluded that this association illustrates the importance of an adequately responding barrier function against the continuous exposure to irritants in daily life.
authors.affiliation: Occupational Dermatology Unit, State University Hospital, Groningen, The Netherlands.
authors.forename: R A
authors.initials: RA
authors.lastname: Tupker
authors.forename: J
authors.initials: J
authors.lastname: Pinnagoda
authors.forename: J P
authors.initials: JP
authors.lastname: Nater
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007509:Irritants / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012879:Skin Physiological Phenomena; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014870:Water Loss, Insensible / Q000187:drug effects*
chemical_list: D007509:Irritants; D012967:Sodium Dodecyl Sulfate