title: Anchor sequence-dependent endogenous processing of human immunodeficiency virus 1 envelope glycoprotein gp160 for CD4+ T cell recognition.
abstract: Human CD4+ T cell clones and cell lines were shown to lyse recombinant vaccinia virus-infected cells that synthesize the HIV-1 envelope glycoprotein gp160. The processing of endogenously synthesized gp160 for recognition by CD4+ T cells required that the protein, after synthesis on the rough endoplasmic reticulum and during subsequent cellular transport, remain attached to the luminal/extracellular membrane face by a hydrophobic anchor sequence.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
authors.forename: M
authors.initials: M
authors.lastname: Polydefkis
authors.forename: S
authors.initials: S
authors.lastname: Koenig
authors.forename: C
authors.initials: C
authors.lastname: Flexner
authors.forename: E
authors.initials: E
authors.lastname: Obah
authors.forename: K
authors.initials: K
authors.lastname: Gebo
authors.forename: S
authors.initials: S
authors.lastname: Chakrabarti
authors.forename: P L
authors.initials: PL
authors.lastname: Earl
authors.forename: B
authors.initials: B
authors.lastname: Moss
authors.forename: R F
authors.initials: RF
authors.lastname: Siliciano
mesh_terms: D000595:Amino Acid Sequence; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015686:Gene Products, env / Q000276:immunology / Q000378:metabolism*; D015752:Genes, env; D006678:HIV / Q000235:genetics / Q000378:metabolism*; D019302:HIV Envelope Protein gp160; D006801:Humans; D011498:Protein Precursors / Q000276:immunology / Q000378:metabolism*; D021382:Protein Sorting Signals / Q000378:metabolism
chemical_list: D015686:Gene Products, env; D019302:HIV Envelope Protein gp160; D011498:Protein Precursors; D021382:Protein Sorting Signals