title: Acquired immunodeficiency syndrome and Epstein-Barr virus.
abstract: Epstein-Barr virus is an important aetiological factor in certain HIV-related syndromes, with its opportunist expression related to the level of host immunodeficiency. In asymptomatic people co-infected with HIV, EBV activity is reflected by increased viral shedding and rises in anti-EBV titres; as immunodeficiency ensues EBV manifests as epithelial hyperproliferation in OHL, and later as B-cell lymphoma in AIDS. The suggested role of EBV as a co-factor in the progression of HIV infection and development of AIDS has not been established, although another herpesvirus, cytomegalovirus, might play such a role. Advances in our understanding of HIV regulation and its interaction with other latent (herpes) viruses should provide important molecular and pharmacological approaches to the clinical management of advanced HIV disease.
authors.forename: R K
authors.initials: RK
authors.lastname: Lau
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000209:etiology; D001402:B-Lymphocytes / Q000276:immunology / Q000382:microbiology; D004938:Esophageal Neoplasms / Q000209:etiology; D006678:HIV / Q000472:pathogenicity; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human; D006801:Humans; D007108:Immune Tolerance; D007971:Leukoplakia / Q000209:etiology; D008232:Lymphoproliferative Disorders / Q000209:etiology; D009062:Mouth Neoplasms / Q000209:etiology