Immunosuppression inhibits switch from naive to memory phenotype in human T lymphocytes.
Recently, human T cells have been divided into memory (antigen-primed) and naive (unprimed) subsets, which vary in phenotype and function. Immunosuppressive drugs and heparin have been found to inhibit PHA-induced in vitro switching from naive to memory cell phenotype in a process that is at least partly independent of cell proliferation. Furthermore, T cells isolated from immunosuppressed renal allograft recipients were deficient in their in vitro PHA-induced transition from naive to memory phenotype.
Korczak-Kowalska
G
G
Department of Immunology, Transplantation Institute, Warsaw Medical School, Poland.
Wierzbicki
P
P
Górski
A
A
D000911:Antibodies, Monoclonal; D006801:Humans; D007156:Immunologic Memory; D016130:Immunophenotyping; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents