[Performance modification in sports by beta receptor blockers].
Beta-adrenoceptor-blockers modify the physical performance due to their haemodynamic and metabolic effects. Additionally, these substances influence the concentration of serum-potassium and the thermoregulation. The reduction in heart rate yields to a diminished cardiac output resulting in a restricted muscular blood flow at submaximal and maximal exercise. After beta-blockade, O2-uptake at submaximal work load as well as maximal aerobic capacity is slightly reduced. Lipolysis is restricted by acute beta-blockade, but this effect can be compensated for by enhancement of catecholamine-independent lipolysis during chronic treatment with beta-adrenoceptor blockers. At submaximal loads, glycogenolysis is not influenced; at maximal exercise, glycogenolysis is reduced by non-selective beta-blockers but not by beta 1-specific ones. Arterial peak lactate concentration usually is diminished. After beta-adrenoceptor-blockade, the concentration of serum-potassium increases slightly, and sweat production is enhanced. Beta-adrenoceptor-blockers influence the performance in different sports to a various extent, due to the multitude of the different effects they take.
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Institut für Sportmedizin, Landes Salzburg.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D010807:Physical Endurance / Q000187:drug effects*; D010809:Physical Fitness; D012119:Respiration / Q000187:drug effects*; D013177:Sports
D000319:Adrenergic beta-Antagonists
Leistungsmodifizierung im Sport durch Beta-Rezeptorenblocker.