[The effect of delta-9-tetrahydrocannabinol on the receptor and physicochemical properties of the membranes in the rat brain].
It has been demonstrated that delta-9-THC does not affect the specific binding of 3H-IQNB, 3H-DAGO and 3H-dihydroalprenolol, decreases the level of specific binding 3H-LSD and 3H-spiperone, a 2-3-fold increase in the total and nonspecific binding being observed in this case, and also increases the microviscosity of the rat obtain membranes and disrupts lipid-protein interactions. Increasing the microviscosity of membranes by other method (lipid peroxidation) differently affects the binding of radioactively labeled ligands with the membranes from rat brain.
Eremenko
A V
AV
Uvarova
I S
IS
Kurochkin
I N
IN
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D013759:Dronabinol / Q000494:pharmacology*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects / Q000502:physiology; D008563:Membrane Lipids / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D014783:Viscosity
D008563:Membrane Lipids; D011956:Receptors, Cell Surface; D013759:Dronabinol
Vliianie del'ta-9-tetragidrokannabinola na retseptornye i fiziko-khimicheskie svoĭstva membran golovnogo krys.