[Effect of rhyncophylline on platelet aggregation and experimental thrombosis].
Rhyncophylline (Rhy) produced a potent inhibition of rat platelet aggregation in ex vivo. TXA2 generation in platelet rich plasma from rats treated with Rhy obviously decreased in the collagen-induced group, but was not altered in the AA-induced group. These results suggest that Rhy suppressed the release of AA from platelet phospholipids stimulated by collagen, and this may be one of the mechanisms related to its action on platelet aggregation. Pretreatment with ASA, but not Rhy, reduced plasma PGI2 in rats. In the in vitro system, the PGI2 synthesis in rat aorta was shown to be inhibited by ASA but was not by Rhy. Rhy significantly reduced the number of mice died due to thrombosis by platelet aggregates. ASA prevented collagen plus adrenaline induced thrombotic death while Rhy prevented both ADP and collagen plus adrenaline induced thrombotic death.
Jin
R M
RM
Department of Pharmacology, Shanghai College of Traditional Chinese Medicine.
Chen
C X
CX
Li
Y K
YK
Xu
P K
PK
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004365:Drugs, Chinese Herbal; D026121:Indole Alkaloids; D000078183:Oxindoles; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000517:prevention & control*; D013929:Thromboxane B2 / Q000096:biosynthesis
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D026121:Indole Alkaloids; D000078183:Oxindoles; D010975:Platelet Aggregation Inhibitors; C052714:rhyncophylline; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha