title: Effect of fasting, self-selected and isocaloric glucose and fat meals and intravenous feeding on plasma zinc concentrations.
abstract: This study investigated the effect of fasting, self-selected meals and isocaloric oral glucose and fat meals and intravenous (i.v.) feeding on plasma zinc concentrations in men. Plasma zinc remained stable when volunteers fasted all day, but self-selected meals and 600 kCal of dextrose or fat emulsion caused significantly reduced plasma zinc concentrations [mean (SD) 12.1 (1.4), 12.3 (0.6) and 12.2 (0.7) mumol/L at 1400 h, respectively, compared with a fasting level of 13.9 (1.6) mumol/L at 0800 h, P less than 0.05]. In patients undergoing intravenous hyperalimentation, plasma zinc decreased from 12.0 (1.4) mumol/L at 0800 h to 10.0 (1.1) mumol/L at 1400 h [mean (SD), P less than 0.01]. These data show that both enteral and i.v. feeding cause a decline in plasma zinc and that glucose alone is not responsible for this post-prandial fall since ingestion of isocaloric amounts of glucose or fat have a similar effect.
authors.affiliation: Department of Medicine, St James's University Hospital, Leeds, UK.
authors.forename: H F
authors.initials: HF
authors.lastname: Goode
authors.forename: D A
authors.initials: DA
authors.lastname: Robertson
authors.forename: J
authors.initials: J
authors.lastname: Kelleher
authors.forename: B E
authors.initials: BE
authors.lastname: Walker
mesh_terms: D002940:Circadian Rhythm; D003424:Crohn Disease / Q000097:blood* / Q000178:diet therapy; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology*; D005215:Fasting; D006801:Humans; D008297:Male; D010288:Parenteral Nutrition; D012646:Self Administration; D012709:Serum Albumin / Q000032:analysis; D013054:Spectrophotometry, Atomic; D015032:Zinc / Q000097:blood*
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D012709:Serum Albumin; D015032:Zinc