[The role of changes in the bioelectrical activity of the cardiomyocytes in the antiarrhythmic effect of adaptation to hypobaric hypoxia].
The adaptation to periodic hypoxia increases the AP duration in the cardiomyocytes of the rat isolated cardiac papillary muscles; prevents the depression of the resting potential, of the AP amplitude and duration in high calcium concentration and high-frequency stimulation. The adaptation also limits the contracture of papillary muscles and the depression of the resting potential in the cardiomyocytes in hypo-sodium solution. The adaptation seems to enhance the efficacy of the membrane mechanisms of the ion transport in cardiomyocytes, whereas subsequent changes in bioelectrical activity play a major part in antiarrhythmic effect of the adaptation.
Meerson
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D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology*; D000531:Altitude; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000517:prevention & control*; D001273:Atmosphere Exposure Chambers; D002118:Calcium / Q000502:physiology; D002122:Calcium Chloride / Q000008:administration & dosage; D004558:Electric Stimulation / Q000379:methods; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D010210:Papillary Muscles / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage
D012965:Sodium Chloride; D002122:Calcium Chloride; D002118:Calcium
Rol' izmeneniĭ bioélektricheskoĭ aktivnosti kardiomiotsitov v antiaritmicheskom éffekte adaptatsii k gipobaricheskoĭ gipoksii.