Chloroquine distribution in postmortem cases.
Chloroquine concentrations in blood and tissues were examined in overdose and non-overdose cases to determine appropriate ranges for interpretation. Twenty-nine literature overdose cases and 8 non-overdose literature cases were compared with this laboratory's findings. The results indicate significant postmortem redistribution of chloroquine. Combining this laboratory's results and the literature results indicates that using a liver concentration of 150 mg/kg as a cutoff between overdose and non-overdose concentrations properly identified 30 of the 34 published cases containing liver chloroquine and 19 of the 20 presented cases.
Kuhlman
J J
JJ
Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC.
Mayes
R W
RW
Levine
B
B
Jones
R
R
Wagner
G N
GN
Smith
M L
ML
D000060:Accidents, Aviation; D001921:Brain / Q000378:metabolism; D002738:Chloroquine / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D002849:Chromatography, Gas; D062787:Drug Overdose / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism; D008889:Military Personnel; D009104:Multiple Trauma / Q000473:pathology; D011180:Postmortem Changes; D014018:Tissue Distribution; D014481:United States
D002738:Chloroquine