title: Pancreatic, hepatic, and duodenal mucosal bicarbonate secretion during infusion of secretin and cholecystokinin. Evidence of the importance of hepatic bicarbonate in the neutralization of acid in the duodenum of anaesthetized pigs.
abstract: The effect of infusion of secretin alone or in combination with cholecystokinin (CCK) on pancreatic, hepatic, and duodenal mucosal bicarbonate secretion was studied in anaesthetized pigs. After laparotomy, catheters were inserted into the common bile duct, the pancreatic duct, and both ends of the duodenum. Pancreatic, hepatic, and duodenal mucosal secretions were collected during intraportal infusion of increasing doses of secretin, either alone or in combination with CCK. During infusion of secretin in doses that caused physiologic increases in plasma secretin concentrations the liver produced significantly more bicarbonate than the pancreas. A physiologic dose of CCK augmented the effect of secretin on both hepatic and pancreatic bicarbonate secretion, but the hepatic production of bicarbonate was still larger than the pancreatic production. Neither secretin alone nor secretin combined with CCK caused any changes in duodenal mucosal bicarbonate secretion. These results suggest that the liver plays an important role in the neutralization of acid in the duodenum.
authors.affiliation: Dept. of Medical Gastroenterology, Odense University Hospital, Denmark.
authors.forename: M A
authors.initials: MA
authors.lastname: Ainsworth
authors.forename: L
authors.initials: L
authors.lastname: Ladegaard
authors.forename: P
authors.initials: P
authors.lastname: Svendsen
authors.forename: P
authors.initials: P
authors.lastname: Cantor
authors.forename: O
authors.initials: O
authors.lastname: Olsen
authors.forename: O B
authors.initials: OB
authors.lastname: Schaffalitzky de Muckadell
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D002766:Cholecystokinin / Q000494:pharmacology*; D004386:Duodenum / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D007262:Infusions, Intravenous; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D012633:Secretin / Q000494:pharmacology*; D013552:Swine
chemical_list: D001639:Bicarbonates; D012633:Secretin; D002766:Cholecystokinin