A study on platelet function in idiopathic scoliosis.
Because platelets and muscle cells share the same contractile proteins--actin and myosin--platelets may serve as a model for muscle research. To study the functional abnormalities and ultrastructural changes of platelets and to determine whether or not abnormalities in muscle contractile proteins and collagen play an important role in the pathogenesis of idiopathic scoliosis, the bleeding time, the platelet aggregation test, and the titers of platelet plasminogen activator inhibitors were measured and the electron microscopic findings were examined in 52 idiopathic scoliosis patients aged 7 to 28 years and in 49 normal individuals aged 8 to 38 years as a control group. We found no statistically significant difference between the two groups in the bleeding time, the platelet aggregation test, and the titers of platelet plasminogen activator inhibitors. In the electron microscopic findings, no specific abnormalities were found in platelets of idiopathic scoliosis patients. We concluded that idiopathic scoliotic patients have normal morphology and function of platelets, and there is no important role of contractile proteins in the pathogenesis of idiopathic scoliosis. In addition, since the bleeding time was in the normal range, no evidence of subendothelial collagen dysfunction was found in the idiopathic scoliosis patients.
Suk
S I
SI
Department of Orthopedic Surgery, College of Medicine, Seoul National University, Korea.
Kim
I K
IK
Lee
C K
CK
Koh
Y D
YD
Yeom
J S
JS
D000293:Adolescent; D000328:Adult; D001760:Bleeding Time; D001792:Blood Platelets / Q000648:ultrastructure*; D002648:Child; D006801:Humans; D008854:Microscopy, Electron; D015849:Plasminogen Inactivators / Q000032:analysis; D010974:Platelet Aggregation; D012600:Scoliosis / Q000097:blood*
D015849:Plasminogen Inactivators