[The influence of piracetam on the effects of narcotic analgesics].
In experiments on white male mice there was studied the influence of piracetam (250-300 mg/kg) on the analgesic effect of ligands of different types of opioid receptors (morphine, 7.5 mg/kg, DADLE, 7.5 mg/kg, pentazocine, 15 mg/kg) and also on the action of morphine concerning the cardiovascular system and respiration. Piracetam was shown to possess the antagonistic properties with respect to some effects of morphine, however they are not of the universal character and do not depend on the interaction with a certain type of opioid receptors.
Chichenkov
O N
ON
Krylova
I N
IN
Borozdin
M Iu
MIu
Pokatilov
D V
DV
D000701:Analgesics, Opioid / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D004347:Drug Interactions; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008024:Ligands; D008297:Male; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010423:Pentazocine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology; D012119:Respiration / Q000187:drug effects / Q000502:physiology
D000701:Analgesics, Opioid; D008024:Ligands; D011760:Pyrrolidinones; D011957:Receptors, Opioid; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D009020:Morphine; D010423:Pentazocine; D010889:Piracetam
Vliianie piratsetama na éffekty narkoticheskikh anal'getikov.