title: Translocation (14; 18) and (8; 22) in three patients with acute leukemia/lymphoma following centrocytic/centroblastic non-Hodgkin's lymphoma.
abstract: Three patients with centrocytic/centroblastic lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL 2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.
authors.affiliation: Department of Oncology and Hematology, University Hospital Eppendorf, Hamburg, Federal Republic of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Fiedler
authors.forename: H J
authors.initials: HJ
authors.lastname: Weh
authors.forename: W
authors.initials: W
authors.lastname: Zeller
authors.forename: C
authors.initials: C
authors.lastname: Fonatsch
authors.forename: J
authors.initials: J
authors.lastname: Hillion
authors.forename: C
authors.initials: C
authors.lastname: Larsen
authors.forename: B
authors.initials: B
authors.lastname: Wörmann
authors.forename: D K
authors.initials: DK
authors.lastname: Hossfeld
mesh_terms: D000208:Acute Disease; D000368:Aged; D015139:Blotting, Southern; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D014178:Translocation, Genetic