New antitumor promoters: (-)-epigallocatechin gallate and sarcophytols A and B.
EGCG, the main constituent of green tea, and sarcophytols A and B, isolated from a soft coral, inhibited tumor promotion by teleocidin in a two-stage carcinogenesis experiment on mouse skin. EGCG and sarcophytols showed inhibition of tumor development by chemical carcinogenesis. A possibility of developing these compounds as cancer chemopreventives for human beings is discussed.
Fujiki
H
H
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, Japan.
Suganuma
M
M
Suguri
H
H
Takagi
K
K
Yoshizawa
S
S
Ootsuyama
A
A
Tanooka
H
H
Okuda
T
T
Kobayashi
M
M
Sugimura
T
T
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives*; D003063:Cnidaria / Q000032:analysis; D003043:Cocarcinogenesis; D004224:Diterpenes / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000627:therapeutic use*; D008235:Lyngbya Toxins / Q000633:toxicity; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control*; D051379:Mice; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013662:Tea / Q000032:analysis*
D004224:Diterpenes; D005419:Flavonoids; D008235:Lyngbya Toxins; D013662:Tea; C058761:sarcophytol A; C022176:teleocidins; D015127:9,10-Dimethyl-1,2-benzanthracene; C058762:sarcophytol B; D002392:Catechin; C057580:gallocatechol