The chronotropic effect of acetylcholine in the presence of vecuronium and atracurium. A study in the isolated perfused rabbit heart.
The bradycardia produced by 1 microgram acetylcholine in the isolated perfused rabbit heart, in the presence of vecuronium and atracurium, was studied and compared with control. Vecuronium at a concentration of 2.5 micrograms/litre and atracurium 6 micrograms/litre did not enhance the negative chronotropic effect of acetylcholine. Atracurium produced a statistically significant inhibition of the negative chronotropic effect of acetylcholine.
Bellis
D J
DJ
Magill Department of Anaesthetics, Westminster Hospital, London.
Day
S
S
Barnes
P K
PK
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001279:Atracurium / Q000494:pharmacology*; D003864:Depression, Chemical; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D010477:Perfusion; D011817:Rabbits; D014673:Vecuronium Bromide / Q000494:pharmacology*
D001279:Atracurium; D014673:Vecuronium Bromide; D000109:Acetylcholine