[The incidence and clinico-genetic characteristics of anomalies of the urinary system organs in children].
In the last 15 years 6,173 autopsy records were studied in the pediatric regional prosectorium and 3,938 children aged from one week to 15 years were examined in the nephrological clinic. It was established that the frequency of urinary system anomalies among children who had died ranged from 3.8 to 4.4%, while the fraction of multiple anomalies including lesions of the organs of the urinary system had somewhat increased (p less than 0.05). To determine exactly the possible role of genetic factors in the pathogenesis of anomalies of the urinary system organs, the authors studied the distribution of antigens of the HLA system in patients with this pathological condition. A total of 100 children with anomalies of organs of the urinary system, their parents, and 120 healthy individuals were examined. Typing was conducted by means of monospecific sera by the microlymphocytotoxic method. There was a tendency to an increase of the frequency of identification (as compared to the controls) of antigen B40 in the group of patients with uropathology, as well as B12 and B35. The authors calculated the relative risk of the development of the anomalies in children who have the listed antigens. The results of the study may be used as an additional criterion in differential diagnosis of uropathies.
Reznik
B Ia
BIa
Podgornaia
T G
TG
Minkov
I P
IP
Kriven'kaia
M N
MN
Glauberzon
B N
BN
D000367:Age Factors; D002648:Child; D004198:Disease Susceptibility; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000002:abnormalities; D007674:Kidney Diseases / Q000151:congenital / Q000175:diagnosis / Q000453:epidemiology; D012307:Risk Factors; D014455:Ukraine / Q000453:epidemiology; D014551:Urinary Tract / Q000002:abnormalities*
D006680:HLA Antigens
Chastota i kliniko-geneticheskaia kharakteristika anomaliĭ organov mochevoĭ sistemy u deteĭ.