Oxidative phosphorylation in mouse liver mitochondria during weaning.
Oxidative energy metabolism in mouse liver mitochondria was examined during weaning using different substrates. During the post-natal development, from suckling to weanling stage, the respiration rates showed a temporary decrease. These altered levels recovered in the adults. Respiration rates with the three substrates studied namely, glutamate, beta-hydroxybutyrate and succinate showed the same pattern. However, the levels of primary dehydrogenase as well as that of basal adenosine triphosphatase were not significantly altered during weaning. The content of cytochromes aa3 and b significantly decreased during this period. The results indicate that cytochrome aa3 may be of primary importance in the restoration of full respiratory function in mitochondria after the weaning period.
Subramanian
M
M
Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Katyare
S S
SS
D020155:3-Hydroxybutyric Acid; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D003573:Cytochrome b Group / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006885:Hydroxybutyrates / Q000378:metabolism; D066298:In Vitro Techniques; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D014886:Weaning
D003573:Cytochrome b Group; D005971:Glutamates; D006885:Hydroxybutyrates; D013386:Succinates; D018698:Glutamic Acid; D019802:Succinic Acid; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases; D020155:3-Hydroxybutyric Acid