[Study of the activity of membrane-bound leukocyte enzymes in chronic acrylonitrile poisoning in experimental studies and occupational environment].
It was established that acrylonitrile (AN) toxic action resulted in changes in the morphofunctional characteristics of white blood cells. Deviations were found in the activity of the marker enzymes of alkaline phosphatase neutrophil secretory granules and myeloperoxidase. Other changes were established in the markers of acid phosphatase lysosomes, the enzyme of plasma membrane--5 nucleotidase, in the endoplasm network of glucose-6-phosphatase, in succinate dehydrogenase mitochondria, and in alpha-glycerolphosphate dehydrogenase. Along with a considerably lowered succinate dehydrogenase activity, lymphocyte cell deformation against the activity of this enzyme was detected. The data obtained specified newly revealed changes in the blood at AN intoxication and indicated to innovated means of its prophylaxis.
Grigor'eva
I K
IK
D000181:Acrylonitrile / Q000506:poisoning*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D004195:Disease Models, Animal; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology*; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced*; D009195:Peroxidase / Q000037:antagonists & inhibitors / Q000097:blood*; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors / Q000097:blood*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors / Q000097:blood*
D009195:Peroxidase; D013385:Succinate Dehydrogenase; D010744:Phosphoric Monoester Hydrolases; D000181:Acrylonitrile
Issledovanie aktivnosti membranno-sviazannykh fermentov leĭkotsitov pri khronicheskoĭ intoksikatsii akrilonitrilom v éksperimente i v usloviiakh proizvodstva.