Reaction of NO with O2-. implications for the action of endothelium-derived relaxing factor (EDRF).
Under physiological pH conditions (pH 7.2-7.4) the rate constant of the reaction NO + O2- yielding peroxonitrite (ONOO-) was determined as k = (3.7 +/- 1.1) x 10(7) M-1 s-1. The decay of peroxonitrite at this pH follows first order kinetics with a rate constant of 1.4 s 1. At alkaline pH peroxonitrite is practically stable. Possible consequences of these reactions for the biological lifetime of EDRF will be discussed.
Saran
M
M
Institut für Strahlenbiologie, GSF Research Center, Neuherberg, W. Germany.
Michel
C
C
Bors
W
W
D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009566:Nitrates / Q000737:chemistry; D009569:Nitric Oxide / Q000737:chemistry* / Q000378:metabolism*; D013481:Superoxides / Q000737:chemistry*
D009566:Nitrates; D013481:Superoxides; C039642:peroxynitric acid; D009569:Nitric Oxide