Effective inactivation of human immunodeficiency virus with chlorhexidine antiseptics containing detergents and alcohol.
The antiseptics 4% chlorhexidine gluconate detergent formulation containing 4% isopropyl alcohol (Hibiclens/Hibiscrub) and 0.5% chlorhexidine gluconate in 70% isopropyl alcohol with emollients (Hibistat/Hibisol) efficiently inactivated human immunodeficiency virus (HIV) produced in cell culture within 15 seconds. These antiseptics were completely effective at 1:100 and 1:5 dilutions, respectively. Therefore, use of these products according to the manufacturer's instructions (i.e. undiluted) for routine disinfection of hands following contact with HIV-contaminated materials, as well as immediate disinfection of abrasions or cuts exposed to HIV, should have significant protective effects.
Montefiori
D C
DC
Department of Pathology, Vanderbilt University Medical School, Nashville, TN 37232.
Robinson
W E
WE
Modliszewski
A
A
Mitchell
W M
WM
D000433:1-Propanol / Q000494:pharmacology*; D000985:Antisepsis / Q000379:methods* / Q000592:standards; D002461:Cell Line, Transformed; D002710:Chlorhexidine / Q000494:pharmacology*; D003902:Detergents / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000472:pathogenicity; D015367:Human T-lymphotropic virus 2; D006801:Humans; D013501:Surface-Active Agents / Q000494:pharmacology*; D013601:T-Lymphocytes
D003902:Detergents; D013501:Surface-Active Agents; D000433:1-Propanol; D002710:Chlorhexidine