Growth kinetics of fibroblasts from a patient with Ehlers-Danlos syndrome.
A 6-year-old girl with Ehlers-Danlos syndrome (type I) who shows hyperelastic skin, hypermobile joints and delayed wound healing is reported. The growth kinetics of fibroblasts derived from her skin was examined using 3H-thymidine autoradiography. Our study showed that these fibroblasts had poor proliferative activity, compared with normal age-matched fibroblasts. Thus, we could suggest that the pathogenesis of Ehlers-Danlos syndrome was partially attributed to the lack of proliferative activity of the fibroblasts.
Oku
T
T
Department of Dermatology, Shizuoka General Hospital, Japan.
Nakayama
F
F
Takigawa
M
M
Inoue
K
K
Yamada
M
M
D001345:Autoradiography; D002455:Cell Division; D002478:Cells, Cultured; D002648:Child; D004535:Ehlers-Danlos Syndrome / Q000209:etiology / Q000473:pathology*; D005260:Female; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D012867:Skin / Q000473:pathology