title: A randomized controlled trial of low-dose prednisone and ciclosporin versus high-dose prednisone in nephrotic syndrome of children.
abstract: Twenty-eight patients with an onset of nephrotic syndrome within 1 year were randomized to receive either ciclosporin and low-dose prednisone or high-dose prednisone alone. Both groups were treated for 8 weeks. Thirteen of 14 children receiving combined therapy underwent remission versus only 8 of 14 children receiving prednisone alone (p less than 0.05). However, there was no difference between the two groups as regards the duration of remission after discontinuation of therapy. In patients receiving combined therapy, immunological studies showed that high interleukin producers had a more sustained remission. There was no evidence of ciclosporin-induced nephrotoxicity in this short-term therapeutic trial.
authors.affiliation: Department of Pediatrics, State University of New York Health Science Center, Brooklyn.
authors.forename: A
authors.initials: A
authors.lastname: Tejani
authors.forename: M
authors.initials: M
authors.lastname: Suthanthiran
authors.forename: A
authors.initials: A
authors.lastname: Pomrantz
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage*; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy / Q000276:immunology; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007223:Infant; D007376:Interleukin-2 / Q000096:biosynthesis; D009402:Nephrosis, Lipoid / Q000188:drug therapy / Q000276:immunology; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000276:immunology; D011241:Prednisone / Q000008:administration & dosage*; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D007376:Interleukin-2; D016572:Cyclosporine; D011241:Prednisone