Biochemical basis of the diabetic embryopathy.
Signal transduction, phosphatidylinositol turnover and the arachidonic acid cascade appear to be a final common pathway involved in the differentiation and development of the early embryo and several embryonic organ structures. Disruption of this biochemical pathway by various agents may account for the occurrence of the diabetic embryopathy.
Goldman
A S
AS
Center for Craniofacial Anomalies, University of Illinois, College of Medicine, Chicago 60612.
Goto
M P
MP
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism; D005260:Female; D005315:Fetal Diseases / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications / Q000378:metabolism*