Expression of complement receptors CR1 and CR3 in patients with juvenile periodontitis.
The expression of two complement receptors, CR1 and CR3, was investigated in a group of 11 patients with localized juvenile periodontitis (LJP) before and after stimulation of their peripheral blood neutrophils and monocytes with a chemotactic factor. A total deficiency of CR1 or CR3 was not observed in any patient. Abnormally high or low values were seen in some individuals; however, tests repeated a few months later suggested that the abnormal expression of CR1 and CR3 were not causing the disease, but were probably the result of the inflammation and infection usually associated with untreated juvenile periodontitis.
Palmer
R
R
Department of Periodontology, United Medical School, Guy's Hospital, London.
Carr
T
T
Adinolfi
M
M
D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood / Q000473:pathology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D009000:Monocytes / Q000648:ultrastructure; D009504:Neutrophils / Q000648:ultrastructure; D011951:Receptors, Complement / Q000276:immunology / Q000502:physiology*
D000911:Antibodies, Monoclonal; D011951:Receptors, Complement