title: Substituent effects on the binding constants of arsenical-dithiol adducts.
abstract: Proton nuclear magnetic resonance spectroscopy (1H NMR) was used to determine the relative binding constants for several arsenical-dithiol adducts. The compounds investigated were 2,3-dimercaptopropanol (British anti-lewisite; BAL), 1,2-ethane dithiol (ET), and 1,2-propane dithiol (PDT). It was found that PDT has a significantly higher affinity than ET or BAL for phenyldichloroarsine (PDA) in methanol.
authors.affiliation: Department of Chemistry, Clemson University, SC 29634-1905.
authors.forename: K
authors.initials: K
authors.lastname: Dill
authors.forename: L H
authors.initials: LH
authors.lastname: Huang
authors.forename: E L
authors.initials: EL
authors.lastname: McGown
authors.forename: S H
authors.initials: SH
authors.lastname: Youn
authors.forename: R J
authors.initials: RJ
authors.lastname: O'Connor
mesh_terms: D001152:Arsenicals / Q000737:chemistry*; D001665:Binding Sites; D004112:Dimercaprol / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008623:Mercaptoethanol / Q000031:analogs & derivatives* / Q000737:chemistry; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D001152:Arsenicals; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; D008623:Mercaptoethanol; C053663:phenyldichloroarsine; C031854:1,2-ethanedithiol; C071142:1,2-dimercaptopropane; D011407:Propane