[Metabolic and cardiovascular changes in experimental diabetes, stress and orchiectomy].
When Aloran (Al) was administered to normal or orchiectomized animals, the adult ones proved to be more sensitive, most normal animals (77.7%) developing a DAla and the remainder (22.3%) a DAlc, while of the orchiectomized animals 66.6 developed a DAlc and 33.4% presented a decreased glucose tolerance. 33.4% of the young normal developed a DAla and 66.7% a DAlc, while of the young orchiectomized ones 33.4% presented a DAlc and 66.7% a STG. No matter of age, orchiectomy induced an increased resistance to the various action of Al. Glycemia and lipid fractions, especially LT and TG were significantly elevated in the normal animals with DAla and in the young orchiectomized animals with DAlc. Insulinemia was elevated in most young animals, except for the orchiectomized ones with DAlc, in which it decreased. Serum cholesterol was the most markedly elevated in the adult animals belonging to the group ACTH + D2 + Al, form DAlc. Histopathologically, in this last group degenerative lesions and microcalcifications in aorta and interstitial infiltrate and homogenization of myocardial fibres in the myocardium were found.
Dinu
M
M
Institutul de Medicină şi Farmacie Iaşi.
Colev
V
V
Bădescu
M
M
Dobrescu
G
G
Bădescu
A
A
Rusu
V
V
Mîndreci
I
I
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects* / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000473:pathology; D004872:Ergocalciferols / Q000494:pharmacology; D008297:Male; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000378:metabolism* / Q000473:pathology; D013737:Testis / Q000502:physiology*
D004872:Ergocalciferols; D000496:Alloxan; D000324:Adrenocorticotropic Hormone
Modificări metabolice şi cardiovasculare in condiţii de diabet experimental, stres şi orhiectomie.