Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and 145Sm as a brachytherapy source.
A technique to produce radiation enhancement during interstitial brain tumor irradiation by using a radiation sensitizer (iododeoxyuridine-IdUrd) and by stimulation of Auger electron cascades through absorption of low-energy photons in iodine is described. Clinical studies using iododeoxyuridine, 192Ir as a brachytherapy source, and external radiation have produced promising results. Substituting 145Sm for 192Ir in this protocol is planned to evaluate the enhanced dose resulting from photon activation therapy.
Goodman
J H
JH
Department of Surgery, Ohio State University, Columbus.
Gahbauer
R A
RA
Kanellitsas
C
C
Clendenon
N R
NR
Laster
B H
BH
Fairchild
R G
RG
D001918:Brachytherapy / Q000379:methods*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D007065:Idoxuridine / Q000008:administration & dosage*; D011838:Radiation-Sensitizing Agents; D011868:Radioisotopes / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D012493:Samarium / Q000627:therapeutic use; D013238:Stereotaxic Techniques
D011838:Radiation-Sensitizing Agents; D011868:Radioisotopes; D012493:Samarium; D007065:Idoxuridine