A single plasma sample method for estimation of the glomerular filtration rate in infants and children using iohexol, I: Establishment of a body weight-related formula for the distribution volume of iohexol.
This study was performed in order to develop a method for estimation of the glomerular filtration rate (GFR) from a single plasma sample based upon the plasma disappearance rate of the non-ionic contrast medium iohexol. The apparent distribution volume for iohexol was measured in 100 infants and children and used for establishment of a weight-related empirical formula for the distribution volume. Using the distribution volume obtained by this formula, a preliminary GFR was calculated from the iodine concentration measured in a plasma sample taken 3 h after injection of iohexol. When this estimate was corrected by another empirically established correction factor, a high degree of agreement was found between a GFR reference method and the 3-h single plasma sample method. In another group of 13 children the 3-h single plasma sample GFR was estimated twice with a 2-day interval, and the day-to-day variations were found to be similar to those obtained with other standard methods.
Stake
G
G
Department of Paediatric Radiology, Rikshospitalet, University Hospital, Oslo, Norway.
Monclair
T
T
D000293:Adolescent; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007472:Iohexol / Q000097:blood* / Q000493:pharmacokinetics; D008297:Male; D008657:Metabolic Clearance Rate; D014018:Tissue Distribution
D007472:Iohexol