[Primates as a model for the study of sleep in man].
After demonstrating the value of the animal model for the study of sleep in man, the author successively considers, in the first part of this investigation, the main characteristics of sleep in non human primates. Circadian rhythm, EEG, neuropharmacological, neuro-anatomical and zootechnical criteria are reviewed. The second part of the investigation describes an application of the use of rhesus monkeys as model to study sleep in the pharmacology of wakefulness. Two techniques, night actography and electroencephalography, which are part of a protocol to evaluate the efficiency and innocuity of new psychostimulants are described and discussed.
Lagarde
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Centre d'Etudes et de Recherches de Médecine Aérospatiale, Division de Neurophysiologie Appliquée, Paris, France.
D000818:Animals; D002415:Cats; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004195:Disease Models, Animal; D004569:Electroencephalography; D006801:Humans; D008251:Macaca / Q000502:physiology*; D008253:Macaca mulatta / Q000502:physiology*; D051379:Mice; D008991:Monitoring, Physiologic; D011323:Primates / Q000502:physiology*; D051381:Rats; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
D000697:Central Nervous System Stimulants
Les primates comme modèles de l'étude du sommeil chez l'homme.