Estimation of coefficients in a model of radiation-induced myelopoiesis from mortality data for mice following X-ray exposure.
The rate coefficients in the model of cell kinetics and mortality introduced by Jones et al. (Radiat. Res. 128, 258-266 (1991)) are estimated using mortality data from several mouse experiments. The evaluated model fits data from a large variety of prompt, protracted, and fractionated irradiations with 250-k Vp X rays with good fidelity. Although the maximum-likelihood estimates are not unique, all estimates lead to greater cell survival than that observed in in vitro experiments on nonterminally differentiated reproducing cells from the marrow.
Morris
M D
MD
Engineering Physics and Mathematics Division, Oak Ridge National Laboratory, Tennessee 37831-6367.
Jones
T D
TD
Young
R W
RW
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D002470:Cell Survival / Q000528:radiation effects; D051379:Mice; D008954:Models, Biological; D015233:Models, Statistical; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000401:mortality*