The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2.
Using an interspecies backcross, we have mapped the HOX-5 and surfeit (surf) gene clusters within the proximal portion of mouse chromosome 2. While the HOX-5 cluster of homeobox-containing genes has been localized to chromosome 2, bands C3-E1, by in situ hybridization, its more precise position relative to the genes and cloned markers of chromosome 2 was not known. Surfeit, a tight cluster of at least six highly conserved "housekeeping" genes, has not been previously mapped in mouse, but has been localized to human chromosome 9q, a region of the human genome with strong homology to proximal mouse chromosome 2. The data presented here place HOX-5 in the vicinity of the closely linked set of developmental mutations rachiterata, lethargic, and fidget and place surf close to the proto-oncogene Abl, near the centromere of chromosome 2.
Stubbs
L
L
Genome Analysis Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom.
Huxley
C
C
Hogan
B
B
Evans
T
T
Fried
M
M
Duboule
D
D
Lehrach
H
H
D000818:Animals; D002874:Chromosome Mapping; D000013:Congenital Abnormalities / Q000235:genetics / Q000662:veterinary; D005260:Female; D005796:Genes; D005801:Genes, Homeobox; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D009115:Muridae / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics; D016315:Proto-Oncogene Proteins c-abl; D011519:Proto-Oncogenes; D011995:Recombination, Genetic
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D016315:Proto-Oncogene Proteins c-abl