title: Comparative efficacy study of combination fansidar-sulphate quinine and fansidar-HCl tetracycline in falciparum malaria in children above 7 years old.
abstract: The objective of this study is to compare the results of treatment of children with falciparum malaria with the combinations of fansidar-sulphate quinine and fansidar-chlortetracycline as an alternative treatment of chloroquine resistant falciparum malaria. This study was carried out prospectively on 45 cases with the age equal or above 7 years, who had been admitted in the Pediatric Department, Gunung Wenang Hospital Manado during the period of January 1989-December 1989. Twenty three cases had been treated with fansidar-sulphate quinine and 22 cases with fansidar-chlortetracycline, all of them underwent blood examinations for malaria for 7 consecutive days (day 0-8). Asexual parasitemia and fever in the fansidar-sulphate quinine group significantly disappeared more rapidly than in the fansidar-chlortetracycline group (p less than 0.03 and less than 0.005). There occurred neither drug resistance nor serious side effect in both groups.
authors.affiliation: Department of Child Health Medical School Sam Ratulangi University, Manado, Indonesia.
authors.forename: K
authors.initials: K
authors.lastname: Silitonga
authors.forename: T H
authors.initials: TH
authors.lastname: Rampengan
mesh_terms: D000293:Adolescent; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D004338:Drug Combinations; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D011446:Prospective Studies; D011739:Pyrimethamine / Q000627:therapeutic use*; D011803:Quinine / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000627:therapeutic use*; D013752:Tetracycline / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011803:Quinine; D013752:Tetracycline; D011739:Pyrimethamine