[The effect of diabeton and metformin on the free-radical oxidation processes and the structural characteristics of the phospholipid composition of the erythrocyte membranes in non-insulin-dependent diabetes mellitus].
Newly detected noninsulin--dependent diabetes mellitus is shown to have changes in phospholipid structure of erythrocytic membranes: a fall in total phospholipids, sphingomyelin, phosphatidylcholine, phosphatidic acid, a trend to increasing lysophosphatidylcholine. The shifts go in parallel with lipid peroxidation activation. Carbohydrate metabolism compensation is not enough to eradicate the shifts. The process is also dependent on the properties of a sugar-reducing drug. Diabeton is recommended as beneficial in this respect, while metformin is efficient in combinations.
Buĭdina
T A
TA
Kozlov
G S
GS
Balabolkin
M I
MI
D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004341:Drug Evaluation; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008563:Membrane Lipids / Q000097:blood*; D008687:Metformin / Q000627:therapeutic use*; D010084:Oxidation-Reduction / Q000187:drug effects; D010743:Phospholipids / Q000097:blood*; D013424:Sulfanilamides / Q000627:therapeutic use*
D005609:Free Radicals; D007004:Hypoglycemic Agents; D008563:Membrane Lipids; D010743:Phospholipids; D013424:Sulfanilamides; D008687:Metformin; C070071:diabeton
Vliianie diabetona i metformina na protsessy svobodnoradikal'nogo okisleniia i strukturnye osobennosti fosfolipidnogo sostava éritrotsitarnykh membran pri insulinnezavisimom sakharnom diabete.