Lipoxygenase-inhibitory action of antiviral polymeric oxidation products of polyphenols.
Various polymeric oxidation products of polyphenols strongly inhibited the purified lipoxygenase of rabbit reticulocytes, whereas the prostaglandin H synthase of sheep vesicular gland was only weakly inhibited. The oxidized polymeric preparations of caffeic acid, 2,5-dihydroxytoluene and 3,4-dihydroxytoluene were the most potent lipoxygenase inhibitors. Since such preparations are also known to inhibit herpes simplex virus in an early stage of the virus-cell interaction it is proposed that lipoxygenase metabolites are involved in virus-induced changes in the cell metabolism.
Schewe
C
C
Institute of Biochemistry, Medical School (Charité), Humboldt University Berlin, Germany.
Klöcking
R
R
Helbig
B
B
Schewe
T
T
D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology*; D002109:Caffeic Acids / Q000378:metabolism / Q000494:pharmacology; D002396:Catechols / Q000378:metabolism / Q000494:pharmacology; D005419:Flavonoids; D006873:Hydroquinones / Q000378:metabolism / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010636:Phenols / Q000378:metabolism* / Q000494:pharmacology; D011108:Polymers / Q000378:metabolism* / Q000494:pharmacology; D011463:Prostaglandins H / Q000037:antagonists & inhibitors*; D011817:Rabbits; D012156:Reticulocytes / Q000201:enzymology; D012756:Sheep
D000998:Antiviral Agents; D002109:Caffeic Acids; D002396:Catechols; D005419:Flavonoids; D006873:Hydroquinones; D016859:Lipoxygenase Inhibitors; D010636:Phenols; D011108:Polymers; D011463:Prostaglandins H; C018599:4-methylcatechol; C062397:2-methyl-1,4-hydroquinone; C040048:caffeic acid