[Autoradiography of DNA synthesis in colonic mucosa of patients with familial adenomatosis coli].
In connection with routine endoscopic examinations of 31 patients with familial adenomatosis coli and 28 health kindreds of patients with familial adenomatosis coli we investigated by autoradiography the in vitro incorporation of 3H-thymidine into bioptic mucosal particles from colon and adenomas. Within the 5-year follow-up period there was found a significantly increased labelling index of polyps and the surrounding mucosa in patients with polyposis independing on the time elapsed after operation. In 12 of 28 kindreds the histological normal colonic mucosa showed an increased labelling index too. The prognostic value of these results must be proofed by further controls.
Steenbeck
L
L
Zentralinstitut für Krebsforschung, Akademie der Wissenschaften, DDR, Berlin.
Jacobasch
K H
KH
Irro
F
F
D000236:Adenoma / Q000473:pathology; D011125:Adenomatous Polyposis Coli / Q000473:pathology*; D000328:Adult; D001345:Autoradiography / Q000379:methods; D003106:Colon / Q000473:pathology*; D004261:DNA Replication; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D013936:Thymidine
Autoradiografische Untersuchung der DNA-Synthese in der Kolon-Mukosa von Patienten mit familiärer Adenomatosis coli.