Transformation of chronic lymphocytic leukemia to small non-cleaved cell lymphoma: a cytogenetic, immunological, and molecular study.
A patient with chronic lymphocytic leukemia (CLL) transforming into a small non-cleaved cell lymphoma (SNCL) with the occurrence of a t(8;22) is described. The SNCL and the CLL were both found to have a germline lambda light chain gene configuration and the same heavy chain and kappa light chain gene rearrangements. The SNCL was CD10 (CALLA) negative and appeared to be CD5 negative. It is concluded that the SNCL is derived from the CLL and that activation of the c-myc oncogene may have played a role in this transformation.
Litz
C E
CE
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis.
Arthur
D C
DC
Gajl-Peczalska
K J
KJ
Rausch
D
D
Copenhaver
C
C
Coad
J E
JE
Brunning
R D
RD
D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000235:genetics; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D010641:Phenotype; D014178:Translocation, Genetic
D004273:DNA, Neoplasm; D007146:Immunoglobulin lambda-Chains