A new view of prostaglandin E regulation of the immune response.
Prostaglandins, particularly those of the E series, are widely regarded as immunosuppressive products of eukaryotic cells that can downregulate many aspects of B- and T-cell function. In this article, Richard Phipps and colleagues present a different concept of E series prostaglandins, based on recent evidence supporting a role for prostaglandins as potentiators of immunoglobulin class switching and of the synthesis of selected cytokines and cytokine receptors.
Phipps
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RP
Immunology Division, University of Rochester School of Medicine, NY 14642-8704.
Stein
S H
SH
Roper
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RL
D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007134:Immunoglobulin Switch Region / Q000276:immunology*; D007136:Immunoglobulins / Q000276:immunology*; D011458:Prostaglandins E / Q000276:immunology*; D011971:Receptors, Immunologic / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines; D007136:Immunoglobulins; D011458:Prostaglandins E; D011971:Receptors, Immunologic