Activation of the anticancer drug CCNU into a free radical intermediate via UV irradiation--an ESR study.
We studied the formation of a free radical induced by UV irradiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in benzene. It was determined a stable nitroxide radical by ESR spectroscopy. We confirmed that sterically hindered cyclic amine 2,2,6,6-tetramethyl-4-piperidone (TMPone) was transformed into a corresponding stable free nitroxyl radical during UV irradiation. When CCNU was present, the rate of free radical formation from TMPone increased considerably.
Raikov
Z D
ZD
Department of Chemistry and Biochemistry, Laboratory of Molecular Oncology, Stara Zagora, Bulgaria.
Zheleva
A M
AM
Raikova
E T
ET
D001554:Benzene; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D008130:Lomustine / Q000737:chemistry / Q000528:radiation effects*; D014216:Triacetoneamine-N-Oxyl; D014466:Ultraviolet Rays
D005609:Free Radicals; D014216:Triacetoneamine-N-Oxyl; D008130:Lomustine; D001554:Benzene