[Inhibition of the metastasis of Lewis lung carcinoma in mice by the administration of spasmolytin, midantan and L-DOPA].
Different combinations and doses of neurotropic drugs of the central action (spasmolytine, midantane, L-DOPA) coupled with the surgical removal of the lung Lewis carcinoma were studied for their effect on the metastatic spreading in C57BL/6 mice. It has been established that the long-term use of spasmolytine and midantane before and after the operation inhibits the metastatic process, that is expressed in the total volume reduction of lung metastases, lack of metastases in a number of mice and augmentation of the average life. Such method of drug application is more effective in the metastatic growth inhibition as against their application only in the pre- or postoperation periods as well as with the use of the other neurotropic drug combinations.
Syromiatnikov
A V
AV
Alistratov
A V
AV
Balitskiĭ
K P
KP
D000547:Amantadine / Q000627:therapeutic use*; D000818:Animals; D003131:Combined Modality Therapy; D004158:Diphenylacetic Acids / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007980:Levodopa / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D011182:Postoperative Care; D011300:Preoperative Care
D004158:Diphenylacetic Acids; D007980:Levodopa; D000547:Amantadine
Tormozhenie metastazirovaniia kartsinomy legkogo L'iuis u mysheĭ pri vvedenii spazmolitina, midantana i L-DOFA.