A panel of restriction fragment length polymorphisms for chromosomal band 11p13.
A panel of seven chromosome 11p13 restriction fragment length polymorphisms (RFLPs) detected by five DNA probes is described. Two alleles were identified for each polymorphism, and Mendelian segregation of alleles was observed. Allele frequencies range from 0.13/0.87 to 0.44/0.56. This panel of 11p13 RFLPs will be useful for linkage studies investigating the role of 11p13 genes in Wilms' tumor, aniridia, and genitourinary anomalies. Additionally, these RFLPs will be important tools for studying tumor-specific 11p13 alterations in Wilms' tumor and other cancers.
Huff
V
V
Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Compton
D A
DA
Strong
L C
LC
Saunders
G F
GF
D000483:Alleles; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D008040:Genetic Linkage; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
D015342:DNA Probes