[The effect of polyfunctional macroheterocycles on the rhythmic and contractile activity of the myocardium in animals].
The effect of the polyfunctional macroheterocycles on the rhythmic and contractile activity of the rat myocardium was found to depend on their concentration. A two-phasic effect upon contractility of the papillary muscles was revealed: a short-term (up to 20 sec) positive inotropic effect followed by a stable depression. The most active drug of this class, dicyclohexano-18-crown-6, prevented the positive inotropic action of classic stimulants (catecholamines and strophantin) upon the contractile function of the heart.
Shevchuk
V G
VG
Pliska
A I
AI
Bidzilia
V A
VA
D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004988:Ethers, Cyclic / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D051381:Rats
D002317:Cardiovascular Agents; D004988:Ethers, Cyclic; D006571:Heterocyclic Compounds
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