title: Ceftazidime monotherapy is as effective as ceftazidime combined with gentamicin in the treatment of febrile neutropenic patients.
abstract: To evaluate the efficacy of ceftazidime monotherapy in the empirical treatment of febrile neutropenic patients, a randomized trial was performed of ceftazidime (C) vs. ceftazidime and gentamicin (C + G) with the addition of teicoplanin (T) for those patients with a long intravenous line-associated infection. Success without modification at the end of treatment was seen in 32.7% (C), 28.3% (C + G), 52.4% (C + T) and 65.2% (C + G + T). Monotherapy with ceftazidime is as effective as when used in combination with an aminoglycoside in neutropenia.
authors.affiliation: Department of Haematology, University College and Middlesex School of Medicine, London, UK.
authors.forename: S E
authors.initials: SE
authors.lastname: Kinsey
authors.forename: S J
authors.initials: SJ
authors.lastname: Machin
authors.forename: A H
authors.initials: AH
authors.lastname: Goldstone
mesh_terms: D000380:Agranulocytosis / Q000150:complications*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002423:Cause of Death; D002442:Ceftazidime / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D005839:Gentamicins / Q000627:therapeutic use*; D006020:Glycopeptides / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000150:complications*; D016032:Randomized Controlled Trials as Topic; D017334:Teicoplanin
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D006020:Glycopeptides; D017334:Teicoplanin; D002442:Ceftazidime