[The recurrence of duodenal ulcer in patients undergoing treatment with ranitidine and placebo. A multicenter study].
This randomised, double-blind multicenter study was conducted in order to evaluate the long-term effect (one year) of 150 mg ranitidine vs placebo in 51 patients with healed duodenal ulcer. Seventeen patients had ulcer recurrence at the end of follow-up, one among the 24 patients that received ranitidine and 16 among the 27 patients that received placebo (p = 0.00009). No side effects was detected. Our results support the usefulness of a one-year maintenance therapy with 150 mg ranitidine.
Villalobos
J J
JJ
Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F.
Nava
A A
AA
Elizondo
J
J
Gallo
S
S
Guerrero
C
C
Vargas
F
F
Barrera
A
A
Centeno
F
F
Marín
E
E
Peña
F
F
D000328:Adult; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010919:Placebos; D011446:Prospective Studies; D011899:Ranitidine / Q000627:therapeutic use*; D012008:Recurrence; D013997:Time Factors
D010919:Placebos; D011899:Ranitidine
Recurrencia de la úlcera duodenal en pacientes sometidos a tratamiento con ranitidina y placebo. Estudio multicéntrico.