Effects of amobarbital on pterins and dinucleotides contents in rat brain.
The effects of amobarbital (50 mg.kg-1 ip) on the brain concentrations of biopterin, pterin, reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) were studied by a reverse phase high performance liquid chromatography with fluorescent detector. Amobarbital increased FAD concentrations in 5 brain areas and pterin concentration in the cortex, but decreased biopterin concentrations in the cortex and hippocampus.
Lin
S Z
SZ
Department of Psychology, Peking University, Beijing, China.
Shen
Z
Z
D000654:Amobarbital / Q000494:pharmacology*; D000818:Animals; D001708:Biopterins / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D011622:Pterins / Q000378:metabolism*; D051381:Rats
D011622:Pterins; D009243:NAD; D005182:Flavin-Adenine Dinucleotide; D001708:Biopterins; D000654:Amobarbital