title: Sexual function and neuropeptide Y levels in selected brain regions in male spontaneously hypertensive rats.
abstract: Sexual function was examined in spontaneously hypertensive rats (SHR) from 8 to 20 wk of age and compared with normotensive Wistar-Kyoto (WKY) and Long-Evans rats (LE). Blood pressures (evaluated indirectly) were elevated in SHR (185 +/- 2 and 195 +/- 3 mmHg at 16 and 19 wk of age, respectively) relative to WKY and LE (135-144 mmHg). SHR exhibited good copulatory behavior but displayed fewer erections (less than 20% of the number displayed by WKY or LE) in ex copula tests. At the conclusion of the study (20 wk of age), body weights were lowest in SHR, intermediate in WKY, and greatest in LE. Relative weights of testes were greater in SHR, whereas relative weights of accessory organs, pituitary and adrenal glands, and kidneys were equivalent across strains, as were circulating levels of aldosterone. Circulating levels of testosterone were higher in SHR and WKY than in LE. Neuropeptide Y (NPY) levels in the median preoptic and arcuate nuclei were significantly greater in SHR than in WKY or LE, whereas NPY levels in the medial preoptic area and the suprachiasmatic, hypothalamic dorsomedial, and hypothalamic paraventricular nuclei were equivalent in SHR and WKY, with both greater than LE. No strain differences were evident in the medial nucleus of the amygdala, the bed nucleus of the stria terminalis, the median eminence, the anterior hypothalamic nucleus, or the hypothalamic dorsomedial nucleus.
authors.affiliation: Department of Physiology, Meharry Medical College, Nashville, Tennessee 37208.
authors.forename: J T
authors.initials: JT
authors.lastname: Clark
authors.forename: A
authors.initials: A
authors.lastname: Sahu
authors.forename: J J
authors.initials: JJ
authors.lastname: Mrotek
authors.forename: S P
authors.initials: SP
authors.lastname: Kalra
mesh_terms: D000450:Aldosterone / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D001923:Brain Chemistry; D003307:Copulation; D005837:Genitalia, Male / Q000033:anatomy & histology; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D009478:Neuropeptide Y / Q000032:analysis*; D009929:Organ Size; D009928:Organ Specificity; D010413:Penis / Q000502:physiology / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012726:Sexual Behavior, Animal; D013739:Testosterone / Q000097:blood
chemical_list: D009478:Neuropeptide Y; D013739:Testosterone; D000450:Aldosterone