Prenatal deficiency of phosphate, phosphate supplementation, and rickets in very-low-birthweight infants.
A preliminary study showed that placental histology was abnormal for babies who subsequently had rickets. The findings--low plasma phosphate concentration; maximum percentage tubular reabsorption of phosphate; and high urinary calcium loss--are those of renal conservation of phosphate in the presence of phosphate deficiency. In a controlled trial no baby receiving phosphate supplements (50 mg per day) had radiological evidence of rickets whereas bone changes were apparent in 42% of the control group. Prenatal deficiency of phosphate, due to placental insufficiency, can be corrected by phosphate supplementation thereby preventing rickets of prematurity.
Holland
P C
PC
Department of Paediatrics, University of Oxford, John Radcliffe Hospital, UK.
Wilkinson
A R
AR
Diez
J
J
Lindsell
D R
DR
D002118:Calcium / Q000097:blood; D004334:Drug Administration Schedule; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight / Q000097:blood* / Q000652:urine; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000517:prevention & control* / Q000652:urine; D008297:Male; D008661:Metabolism, Inborn Errors / Q000097:blood*; D009929:Organ Size; D010710:Phosphates / Q000008:administration & dosage / Q000097:blood* / Q000652:urine; D010920:Placenta; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D012279:Rickets / Q000097:blood / Q000517:prevention & control* / Q000652:urine; D013997:Time Factors
D010710:Phosphates; D002118:Calcium