title: Sequence analysis of firefly luciferase family reveals a conservative sequence motif.
abstract: A conservative sequence motif was extracted from an alignment of the firefly luciferase family. AngR derived from a pathogenic bacterium and acetyl-CoA synthetases derived from two ascomycete fungi were identified as members of the firefly luciferase family by a homology search with the motif and other sequence comparison analyses. The motif sequence shares several characteristics with the phosphate-binding sites of phosphoproteins and nucleotide-binding proteins. A multiple alignment and an unrooted phylogenetic tree were constructed for the investigation of evolutionary relationships within the firefly luciferase family.
authors.affiliation: Protein Engineering Research Institute, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Toh
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D001517:Coleoptera / Q000737:chemistry; D008156:Luciferases / Q000737:chemistry*; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment; D013329:Structure-Activity Relationship
chemical_list: D008156:Luciferases