Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome.
L1 is a glycoprotein with an apparent molecular weight of 200 kDa in the developing fetus and adult central nervous system. In the peripheral nervous system, it has a molecular weight of 230 kDa. The L1 protein appears to be encoded by a single gene that has been located on the human X chromosome by in situ hybridization. In this paper we describe restriction variation in genomic DNA Southern analysis between Mus species for the K13 cDNA probe for the L1 neural cell adhesion molecule. We have designated the locus described by this variation as cell adhesion molecule L1, CamL1. The X chromosome linkage and the relative position on the X chromosome coincident with the genes Rsvp/G6pd/Cf-8 were defined in backcross matings involving M. spretus and M. musculus.
Chapman
V M
VM
Molecular and Cellular Biology Department, Roswell Park Cancer Institute, Buffalo, New York 14263.
Keitz
B T
BT
Stephenson
D A
DA
Mullins
L J
LJ
Moos
M
M
Schachner
M
M
D000818:Animals; D015139:Blotting, Southern; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004262:DNA Restriction Enzymes; D005260:Female; D008040:Genetic Linkage; D039841:Leukocyte L1 Antigen Complex; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009115:Muridae / Q000235:genetics; D014960:X Chromosome
D015816:Cell Adhesion Molecules, Neuronal; D039841:Leukocyte L1 Antigen Complex; D004262:DNA Restriction Enzymes