title: [Semi-invasive aspergillosis with involvement of the thoracic wall cured by itraconazole].
abstract: Pulmonary aspergillosis invading the thoracic wall is rare and of sombre prognosis. We report the case of a 49-year old man who developed a pulmonary aspergilloma some time after lung resection and radiotherapy for bronchial adenocarcinoma. Surgical excision of the aspergilloma was followed by sternal, then costal aspergillosis. Conventional surgery and antifungal therapy failed, and the lesion stubbornly followed a chronic course until itraconazole therapy was instituted, resulting in a complete cure which still persists nearly 4 years after withdrawal of any chemotherapy.
authors.affiliation: Service de Pneumologie, Hôpital Tenon, Paris.
authors.forename: B
authors.initials: B
authors.lastname: Milleron
authors.forename: V
authors.initials: V
authors.lastname: Roger
authors.forename: P
authors.initials: P
authors.lastname: Roux
authors.forename: C
authors.initials: C
authors.lastname: Lebreton
authors.forename: A
authors.initials: A
authors.lastname: Koeger
authors.forename: B
authors.initials: B
authors.lastname: Dupont
authors.forename: G
authors.initials: G
authors.lastname: Akoun
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000188:drug therapy; D002283:Carcinoma, Bronchogenic / Q000150:complications; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000188:drug therapy; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D008875:Middle Aged; D012272:Ribs; D013249:Sternum; D013896:Thoracic Diseases / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole
vernacular_title: Aspergillose semi-invasive avec envahissement de la paroi thoracique guérie par itraconazole.