Stereotactic hyperthermia for brain tumors.
We have developed a localized hyperthermia system using computed tomography-stereotactic surgery as malignant brain tumor therapy. In an experimental study, the temperature in the area of the cat brain within 20 mm from a radiofrequency electrode reached more than 43.7 degrees C. Intravenous administration of MCNU during hyperthermia caused a significant increase of MCNU content in the heated brain as compared with a control brain. In the clinical study, localized radiofrequent hyperthermia using stereotactic surgery was performed on 7 malignant deep-seated gliomas and 21 metastatic brain tumors. Especially, combination therapy of stereotactic hyperthermia and chemotherapy was effective treatment for gliomas less than 30 mm deep in the brain.
Yokote
H
H
Department of Neurological Surgery, Wakayama Medical College, Japan.
Komai
N
N
Nakai
E
E
Itakura
T
T
Hayashi
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000970:Antineoplastic Agents; D001254:Astrocytoma / Q000188:drug therapy / Q000628:therapy; D001932:Brain Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000628:therapy*; D002415:Cats; D003131:Combined Modality Therapy; D005260:Female; D005909:Glioblastoma / Q000188:drug therapy / Q000628:therapy; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000008:administration & dosage*; D013238:Stereotaxic Techniques / Q000295:instrumentation*; D014057:Tomography, X-Ray Computed / Q000295:instrumentation*
D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; C020766:ranimustine