title: Acute blindness associated with intracranial tumors in dogs and cats: eight cases (1984-1989).
abstract: Rostral and middle cranial fossa tumors affecting the optic chiasm and resulting in acute visual deficits were diagnosed in 7 dogs and 1 cat. Blindness and dilated nonresponsive pupils were the primary signs in all animals. Other concurrent neurologic deficits were either absent or were equivocal. Behavioral changes, including signs of depression and lethargy, were noticed in 1 dog and the cat subsequent to the onset of blindness. Retinal function was assessed as normal by electroretinography in all animals. The histologic necropsy diagnosis was pituitary carcinoma in 1 dog and the cat and paranasal sinus carcinoma with intracranial extension in 1 dog. A cytologic diagnosis of polycentric lymphosarcoma affecting the optic chiasm was diagnosed in 1 dog. In the remaining 4 dogs, results of computed tomographic imaging or endocrine function testing suggested pituitary gland neoplasia. Four dogs were treated with cobalt-60 radiation or chemotherapy. There was partial return of visual function in only 1 of the dogs treated with radiation.
authors.affiliation: Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
authors.forename: M G
authors.initials: MG
authors.lastname: Davidson
authors.forename: M P
authors.initials: MP
authors.lastname: Nasisse
authors.forename: E B
authors.initials: EB
authors.lastname: Breitschwerdt
authors.forename: D E
authors.initials: DE
authors.lastname: Thrall
authors.forename: R L
authors.initials: RL
authors.lastname: Page
authors.forename: V E
authors.initials: VE
authors.lastname: Jamieson
authors.forename: R V
authors.initials: RV
authors.lastname: English
mesh_terms: D000208:Acute Disease; D000818:Animals; D001766:Blindness / Q000209:etiology / Q000662:veterinary*; D001932:Brain Neoplasms / Q000150:complications / Q000662:veterinary*; D002277:Carcinoma / Q000150:complications / Q000473:pathology / Q000556:secondary / Q000662:veterinary; D002371:Cat Diseases / Q000209:etiology*; D002415:Cats; D003390:Cranial Nerve Neoplasms / Q000150:complications / Q000556:secondary / Q000662:veterinary; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005260:Female; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000473:pathology / Q000662:veterinary; D008297:Male; D009897:Optic Chiasm; D010255:Paranasal Sinus Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed