title: Identification of immunodominant polypeptides common between Anaplasma centrale and Anaplasma marginale.
abstract: High titered antibody from rabbits immunized with Anaplasma centrale or from cattle recovered from A. centrale infection bound predominantly to several 33-36 kDa polypeptides present in both A. centrale and the Israel-NT isolate of Anaplasma marginale. High titered bovine antibody against the Israel-NT isolate of A. marginale also reacted predominantly with A. centrale polypeptides in this size range. The immunodominance of the 33-36 kDa polypeptides and their cross-reactivity indicate that these shared epitopes may be primarily responsible for the cross-protective immunity between A. centrale and A. marginale.
authors.affiliation: Department of Parasitology, Kimron Veterinary Institute, Bet Dagan, Israel.
authors.forename: V
authors.initials: V
authors.lastname: Shkap
authors.forename: E
authors.initials: E
authors.lastname: Pipano
authors.forename: T C
authors.initials: TC
authors.lastname: McGuire
authors.forename: G H
authors.initials: GH
authors.lastname: Palmer
mesh_terms: D000709:Anaplasma / Q000276:immunology*; D000712:Anaplasmosis / Q000276:immunology* / Q000382:microbiology; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology*; D002417:Cattle; D003429:Cross Reactions; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D015151:Immunoblotting; D016056:Immunodominant Epitopes / Q000032:analysis*; D008970:Molecular Weight; D011817:Rabbits
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D016056:Immunodominant Epitopes