title: Age-dependent excretion of alanine aminopeptidase, alkaline phosphatase, gamma-glutamyltransferase and N-acetyl-beta-D-glucosaminidase in human urine.
abstract: Urinary excretion of alanine aminopeptidase, alkaline phosphatase, gamma-glutamyltransferase and N-acetyl-beta-D-glucosaminidase was determined in gel-filtered samples of morning random urine specimens of 442 subjects of various ages (5 days to 58 years). Enzyme excretion related to urinary creatinine (enzyme/creatinine ratio; U/mmol creatinine) significantly decreased with increasing age. Sex-related differences of some enzyme excretions were found in age groups over 6 years. From these investigations, we calculated upper reference intervals (97.5 percentiles) for 5 age-dependent groups of children and adolescents and for one group of adults.
authors.affiliation: Department of Experimental Organ Transplantation, University Hospital Charité, Humboldt University Berlin, GDR.
authors.forename: K
authors.initials: K
authors.lastname: Jung
authors.forename: A
authors.initials: A
authors.lastname: Hempel
authors.forename: K D
authors.initials: KD
authors.lastname: Grützmann
authors.forename: R D
authors.initials: RD
authors.lastname: Hempel
authors.forename: G
authors.initials: G
authors.lastname: Schreiber
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000652:urine*; D000626:Aminopeptidases / Q000652:urine*; D018826:CD13 Antigens; D002648:Child; D002675:Child, Preschool; D005260:Female; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors; D005723:gamma-Glutamyltransferase / Q000652:urine*
chemical_list: D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D006596:Hexosaminidases; D000118:Acetylglucosaminidase; D000626:Aminopeptidases; D018826:CD13 Antigens