Surreptitious drug use by patients in a panic disorder study.
In a double-blind, placebo-controlled trial comparing alprazolam and imipramine for panic disorder, serum analysis revealed that a substantial proportion of the patients took explicitly prohibited anxiolytic medication. Excluding these patients changed the results.
Clark
D B
DB
Department of Psychiatry, Stanford University Medical Center, Calif.
Taylor
C B
CB
Roth
W T
WT
Hayward
C
C
Ehlers
A
A
Margraf
J
J
Agras
W S
WS
D000328:Adult; D000525:Alprazolam / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001008:Anxiety Disorders / Q000188:drug therapy*; D002986:Clinical Trials as Topic / Q000592:standards; D004311:Double-Blind Method; D005239:Fear; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D010043:Outcome and Process Assessment, Health Care; D010200:Panic; D010349:Patient Compliance; D010919:Placebos; D012651:Self Medication
D014151:Anti-Anxiety Agents; D010919:Placebos; D007099:Imipramine; D000525:Alprazolam