Octreotide-induced acute pancreatitis in a patient with acquired immunodeficiency syndrome.
Unremitting diarrhea is a common problem in patients with AIDS. We have reported the case of such a patient who was treated with the somatostatin analogue octreotide for chronic diarrhea and who had acute pancreatitis as a consequence of this therapy. We postulate that the possible mechanism for the pathogenesis of this pancreatic damage was octreotide-induced prevention of pancreatic exocrine secretion. We believe this acted as a "physiologic gallstone", inducing an attack of acute pancreatitis.
Gradon
J D
JD
Division of Infectious Diseases, Maimonides Medical Center, Brooklyn, NY.
Schulman
R H
RH
Chapnick
E K
EK
Sepkowitz
D V
DV
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000208:Acute Disease; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000009:adverse effects*; D010195:Pancreatitis / Q000139:chemically induced* / Q000209:etiology
D015282:Octreotide