Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA.
Human papilloma virus (HPV) DNA sequences (HPV types 16, 18, 33, 35 or uncharacterized) were detected by Southern blot hybridisation and polymerase chain reaction in 84% of 106 early-stage invasive carcinomas of the uterine cervix. Among HPV-positive patients, the risk of overall relapse did not differ with individual HPV types. Compared with HPV-positive patients, those with no detectable HPV DNA had a 2.6 times higher risk of overall relapse (p less than 0.05) and 4.5 times higher risk of distant metastases (p less than 0.01). The 24-month relapse-free survival rate in HPV-positive patients was significantly higher than that in HPV-negative patients (77% vs 40%), and the difference was similar (91% vs 56%) among those who were node-negative. These data indicate that HPV-negative cervical carcinomas may represent a biologically distinct subset of tumours that carry a poorer prognosis than do HPV-positive cancers.
Riou
G
G
Laboratoire de Pharmacologie Clinique et Moléculaire, Institut Gustave Roussy IGR, Villejuif, France.
Favre
M
M
Jeannel
D
D
Bourhis
J
J
Le Doussal
V
V
Orth
G
G
D000230:Adenocarcinoma / Q000032:analysis* / Q000473:pathology; D000328:Adult; D000704:Analysis of Variance; D002294:Carcinoma, Squamous Cell / Q000032:analysis* / Q000473:pathology; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000032:analysis* / Q000473:pathology; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000032:analysis* / Q000473:pathology
D015342:DNA Probes; D004279:DNA, Viral