Mechanism of acute gastrointestinal mucosal damage in endotoxic shock and the effect of Fragmin.
1. PAF and LTs may be mediators of the acute gastrointestinal mucosal damage due to endotoxic shock. 2. LTs may be mediators of the acute gastrointestinal mucosal damage due to PAF administration. 3. LMW heparin and unfractionated heparin prevented the increase of LTs due to endotoxin and PAF administration.
Shiba
T
T
Second Department of Surgery, School of Medicine, Toho University, Tokyo, Japan.
Ikeda
M
M
Hara
A
A
Yoshida
H
H
Kaneko
H
H
Takeuchi
S
S
D000208:Acute Disease; D000818:Animals; D016227:Benzoquinones / Q000627:therapeutic use; D004285:Dogs; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000627:therapeutic use; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D007975:Leukotriene B4 / Q000502:physiology; D016859:Lipoxygenase Inhibitors; D009336:Necrosis; D010742:Phospholipid Ethers / Q000627:therapeutic use; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology; D012772:Shock, Septic / Q000150:complications* / Q000473:pathology
D016227:Benzoquinones; D006495:Heparin, Low-Molecular-Weight; D016859:Lipoxygenase Inhibitors; D010742:Phospholipid Ethers; D010972:Platelet Activating Factor; D007975:Leukotriene B4; C036837:2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; C037913:CV 3988; D006493:Heparin