title: A subpopulation of the avian erythroblastosis virus v-erbA protein, a member of the nuclear hormone receptor family, is glycosylated.
abstract: The v-erbA oncogene of avian erythroblastosis virus is derived from a cellular gene for a thyroid hormone (T4/T3 thyronine) receptor and encodes a DNA-binding protein found principally in the nucleus of the infected cell. I report here that a subpopulation of the v-erbA protein is glycosylated. The v-erbA protein, therefore, is another member of the newly recognized family of eucaryotic transcription factors and related polypeptides which are glycoproteins.
authors.affiliation: Department of Microbiology, University of California, Davis 95616.
authors.forename: M L
authors.initials: ML
authors.lastname: Privalsky
mesh_terms: D001355:Alpharetrovirus / Q000235:genetics*; D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D002467:Cell Nucleus / Q000378:metabolism; D002846:Chromatography, Affinity; D004268:DNA-Binding Proteins / Q000235:genetics; D005796:Genes; D006031:Glycosylation; D018774:Oncogene Proteins v-erbA; D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011988:Receptors, Thyroid Hormone / Q000235:genetics*; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D004268:DNA-Binding Proteins; D018774:Oncogene Proteins v-erbA; D011988:Receptors, Thyroid Hormone; D015682:Retroviridae Proteins, Oncogenic; D011505:Protein-Tyrosine Kinases