Levels of thrombin--antithrombin-III complex and factor VIII activity in relation to post-operative deep vein thrombosis and influence of prophylaxis with a low-molecular-weight heparin.
In a randomized doubled-blind placebo-controlled study, plasma levels of thrombin-antithrombin-III (TAT) and factor VIII activity (VIII:C) were measured pre-operatively and on days 1, 3, 5 and 7 post-operatively in 70 consecutive patients undergoing total hip replacement. Patients received either a subcutaneous injection of low-molecular-weight heparin (LMWH) or placebo once daily. Post-operative deep vein thrombosis (DVT) was diagnosed by bilateral phlebography. The levels of TAT and VIII:C both increased significantly after operation and were not significantly influenced by LMWH. Thirty-three patients in whom post-operative DVT developed had a significantly lower level of VIII:C on day 7, compared with patients without DVT.
Sørensen
J V
JV
Department of Orthopaedics and Radiology, Aalborg Hospital, Denmark.
Borris
L C
LC
Lassen
M R
MR
Christiansen
H M
HM
Schøtt
P
P
Olsen
A D
AD
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis*; D004311:Double-Blind Method; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013917:Thrombin / Q000032:analysis*; D013924:Thrombophlebitis / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*
D006495:Heparin, Low-Molecular-Weight; D000990:Antithrombin III; D005169:Factor VIII; D013917:Thrombin