Effects of azatadine, terfenadine, and astemizole on allergen-induced nasal provocation.
Fifty-six patients with ragweed seasonal rhinitis were challenged intranasally with ragweed. A clinical score (0-12)--including measurements of rhinomanometry, secretions, and sneezes--was generated. Each patient then received either azatadine (A), terfenadine (T), astemizole (AS), or nothing (control), for 1 week. Repeat challenges revealed changes in clinical score with A 3.6 (P less than .01), AS 3.1 (P less than .02), and T 2.7 (P less than .05). All three antihistamines similarly inhibited the nasal provocation response to ragweed.
Small
P
P
Division of Allergy and Clinical Immunology, SMBD-Jewish General Hospital, Montreal, Quebec, Canada.
Barrett
D
D
Biskin
N
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000494:pharmacology*; D016589:Astemizole; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000494:pharmacology*; D001562:Benzimidazoles / Q000009:adverse effects / Q000494:pharmacology*; D003533:Cyproheptadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D007258:Informed Consent; D008875:Middle Aged; D009299:Nasal Provocation Tests; D016032:Randomized Controlled Trials as Topic; D012882:Skin Tests; D016593:Terfenadine
D000485:Allergens; D001559:Benzhydryl Compounds; D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D003533:Cyproheptadine; D016593:Terfenadine; D016589:Astemizole; C006656:azatadine