New peptide mechanism of auriculo-acupuncture electro-analgesia: role of angiotensin II.
In rabbits, auriculo-acupuncture electrostimulation with frequencies of 15 and 100 Hz induced an analgesic effect expressed by a decrease in the amplitude of a cortical somatosensory evoked potential in response to tooth pulp electrostimulation. Intracerebroventricular saralasin injection abolished or blocked the effect of auriculo-acupuncture stimulation at 100 Hz, but not at 15 Hz frequency. Intravenous injection of naloxone abolished the effect of auriculo-acupuncture stimulation at 15 Hz but not at 100 Hz frequency. Methysergide or D,L-p-chlorophenylalanine injection diminished but did not entirely block the effect of auriculo-acupuncture stimulation at 100 Hz. This suggests that the neuropeptide angiotensin II is a antinociceptive factor in dental peptide analgesic mechanisms induced by auriculo-acupuncture stimulation at 100 Hz frequency.
Fedoseeva
O V
OV
P.K. Anokhin Institute of Normal Physiology, USSR Academy of Medical Sciences, Moscow.
Kalyuzhnyi
L V
LV
Sudakov
K V
KV
D015667:Acupuncture Analgesia / Q000379:methods*; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D015671:Electroacupuncture / Q000379:methods*; D009270:Naloxone / Q000494:pharmacology / Q000627:therapeutic use; D010146:Pain / Q000503:physiopathology; D059408:Pain Management; D011817:Rabbits
D000804:Angiotensin II; D009270:Naloxone