title: [The recurrence of duodenal ulcer in patients undergoing treatment with ranitidine and placebo. A multicenter study].
abstract: This randomised, double-blind multicenter study was conducted in order to evaluate the long-term effect (one year) of 150 mg ranitidine vs placebo in 51 patients with healed duodenal ulcer. Seventeen patients had ulcer recurrence at the end of follow-up, one among the 24 patients that received ranitidine and 16 among the 27 patients that received placebo (p = 0.00009). No side effects was detected. Our results support the usefulness of a one-year maintenance therapy with 150 mg ranitidine.
authors.affiliation: Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F.
authors.forename: J J
authors.initials: JJ
authors.lastname: Villalobos
authors.forename: A A
authors.initials: AA
authors.lastname: Nava
authors.forename: J
authors.initials: J
authors.lastname: Elizondo
authors.forename: S
authors.initials: S
authors.lastname: Gallo
authors.forename: C
authors.initials: C
authors.lastname: Guerrero
authors.forename: F
authors.initials: F
authors.lastname: Vargas
authors.forename: A
authors.initials: A
authors.lastname: Barrera
authors.forename: F
authors.initials: F
authors.lastname: Centeno
authors.forename: E
authors.initials: E
authors.lastname: Marín
authors.forename: F
authors.initials: F
authors.lastname: Peña
mesh_terms: D000328:Adult; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010919:Placebos; D011446:Prospective Studies; D011899:Ranitidine / Q000627:therapeutic use*; D012008:Recurrence; D013997:Time Factors
chemical_list: D010919:Placebos; D011899:Ranitidine
vernacular_title: Recurrencia de la úlcera duodenal en pacientes sometidos a tratamiento con ranitidina y placebo. Estudio multicéntrico.