[Clinico-pathogenetic aspects of infectious toxicosis in infants caused by acute pneumonia].
Altogether 101 children under one year of age with infectious toxicosis due to acute pneumonia were examined for the clinical, roentgenomorphological and biochemical aspects of the given condition. The clinical aspects were delineated on the basis of the universal status covered by the formalized case report. The biochemical processes were analyzed according to the content of peroxidation products of membrane lipids, the concentration of hydrogen peroxide, phospholipase activity, antioxidant and antiperoxide defence of the blood as well as according to the physical constants of red blood cell membranes. A direct relationship was discovered between the clinical picture (the degree of toxicosis) and membranopathological processes. The data obtained make it possible to conceive the model of infectious toxicosis as a membranopathological one, induced by the syndrome of the deficiency of antioxidant and antiperoxide enzymes.
Daminov
T A
TA
Tsybul'kin
E K
EK
Fishelev
G I
GI
Shamsiev
F S
FS
Shermatov
K S
KS
D000208:Acute Disease; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007223:Infant; D007231:Infant, Newborn; D015227:Lipid Peroxidation; D011023:Pneumonia, Staphylococcal / Q000150:complications* / Q000378:metabolism; D014115:Toxemia / Q000378:metabolism / Q000382:microbiology*
D006861:Hydrogen Peroxide
Kliniko-patogeneticheskie aspekty infektsionnogo toksikoza u detei rannego vozrasta, vyzvannogo ostrymi pnevmoniiami.