title: Pharmacologic approaches to the treatment of cocaine dependence.
abstract: When pharmacologic agents are considered in the treatment of cocaine addiction, the objective of such treatment--sustained abstinence--must be considered. Medication and medical approaches have been disappointing in the treatment of cocaine overdose. The central neurobiologic mechanism(s) involved in cocaine toxicity are poorly understood. Without a cocaine antagonist, pharmacologic approaches have been less than promising in preventing relapse. Various psychoactive medications have been tried in early cocaine abstinence, with some success.
authors.affiliation: Fair Oaks Hospital, Summit, New Jersey 07901.
authors.forename: W A
authors.initials: WA
authors.lastname: Taylor
authors.forename: M S
authors.initials: MS
authors.lastname: Gold
mesh_terms: D000547:Amantadine / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001971:Bromocriptine / Q000627:therapeutic use; D003042:Cocaine; D015259:Dopamine Agents / Q000627:therapeutic use*; D006801:Humans; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D015259:Dopamine Agents; D001971:Bromocriptine; D000547:Amantadine; D003042:Cocaine