title: [Polymorphisms of the Apo B gene in a healthy population and its association with hyperlipidemia].
abstract: The apoprotein B gene restriction fragment length polymorphism are studied using the endonuclease XbaI, and the pAB3.5C probe was studied in 128 healthy males aged 20-62 years (39.2 +/- 7.6). The genotypic prevalence was X1X1 26.6%; X1X2 47.7% and X2X2 25.7%. The allelic frequency was 50.3% X1 and 49.7 for X2. No differences in prevalence were observed related to age or body mass index. The genotype X2X2 was statistically associated with a 10% increase in total plasma cholesterol, LDL cholesterol and LDL Apo B levels (p less than 0.05). Up to 6% of the total plasma cholesterol levels were dependent on X2X2 genotype as shown by multivariate regression analysis. The X2X2 genotype may be a candidate marker in assessing increased risk for coronary heart disease.
authors.affiliation: Unitat de Recerca de Lípids, Hospital de Sant Joan, Facultat de Medicina, Universitat de Barcelona, Reus, Tarragona.
authors.forename: J
authors.initials: J
authors.lastname: Balanya
authors.forename: S
authors.initials: S
authors.lastname: Marsal
authors.forename: A
authors.initials: A
authors.lastname: La Ville
authors.forename: E
authors.initials: E
authors.lastname: Vilella
authors.forename: P R
authors.initials: PR
authors.lastname: Turner
authors.forename: L
authors.initials: L
authors.lastname: Masana
mesh_terms: D000328:Adult; D000368:Aged; D001055:Apolipoproteins B / Q000097:blood / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005838:Genotype; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011897:Random Allocation
chemical_list: D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D002784:Cholesterol
vernacular_title: Polimorfismos del gen de la Apo B en población sana y su asociación a hiperlipidemias.