Persistent superior oblique paresis as a manifestation of familial periodic cerebellar ataxia.
A brother and sister complained of persistent diplopia due to superior oblique palsies. The cause of their symptoms became apparent when they were diagnosed as having familial periodic cerebellar ataxia (FPCA), a rare autosomal dominant condition. Oral acetazolamide (250 mg twice daily) not only prevented all the periodic symptoms but also relieved their diplopia, which had been present between attacks.
Bain
P G
PG
Department of Neurology, UMDS, Guy's Hospital, London.
Larkin
G B
GB
Calver
D M
DM
O'Brien
M D
MD
D000086:Acetazolamide / Q000627:therapeutic use; D000293:Adolescent; D002524:Cerebellar Ataxia / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D004172:Diplopia / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D010243:Paralysis / Q000209:etiology*
D000086:Acetazolamide