[The growth rate as a parameter of degree of biological malignancy and prediction of metastasis by tumor marker doubling and half time].
We calculated the tumor marker doubling time and half time of many cases with gastric cancer and colorectal cancer and studied significance of those as a prediction of metastasis. Tumor marker doubling time of liver metastasis (28.4 +/- 11.5 days) in 32 cases was significantly shorter from that of lymph node metastasis (42.3 +/- 21.4 days) in 18 cases and of peritonitis carcinomatosa (41.1 +/- 25.8 days) in 21 cases. These result indicate that the tumor marker doubling time will be able to play a role in prediction of recurrent patterns. Tumor marker half time after operation ranged from 4 to 5 days in all cases without recurrence, while the discrepancy from actual half time was observed in cases with metachronous liver metastasis diagnosed within 6 months. These results suggest that the discrepancy from actual half time of tumor marker after operation indicates the latent cancer cells and this plays a role in prediction of metachronous liver metastasis.
Takahashi
Y
Y
Department of Surgery, Kanazawa University, Japan.
Mai
M
M
Kasama
S
S
D014408:Biomarkers, Tumor; D004067:Digestive System Neoplasms / Q000473:pathology*; D006801:Humans; D009362:Neoplasm Metastasis; D011379:Prognosis; D012008:Recurrence
D014408:Biomarkers, Tumor