Retinyl acetate inhibition of 3'-methyl-4-dimethyl-aminoazobenzene induced hepatic neoplasia.
1. Retinyl acetate protected female rats from the hepatocarcinogenic effect of 0.06% 3'-Me-DAB up to 18 weeks. 2. The net effect of retinyl acetate was to retard, not prevent, the action of the hepatocarcinogen since the protection broke down prior to the 30 week time point. 3. The observed elevation of serum LSA by retinyl acetate was unexpected and suggested that some of the difficulties found in its use as a tumor marker may be due to dietary factors. 4. The time necessary for development of preneoplastic lesions in the rats fed 0.01% 3'-Me-DAB was 71 vs 8 weeks for those fed 0.06% 3'-Me-DAB. 5. The effect of retinyl acetate on the lower level of 3'-Me-DAB was to prevent formation of nodules through 71 weeks by which time the unprotected rats fed 0.01% 3'-Me-DAB alone had extensive hepatic nodular development.
Mack
D O
DO
H. L. Snyder Memorial Research Foundation, Winfield, KS 67156.
Reed
V L
VL
Smith
L D
LD
D000264:Adenylosuccinate Lyase / Q000378:metabolism; D000818:Animals; D004224:Diterpenes; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008749:Methyldimethylaminoazobenzene; D019158:N-Acetylneuraminic Acid; D011230:Precancerous Conditions / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D000084562:Retinyl Esters; D012794:Sialic Acids / Q000097:blood; D013997:Time Factors; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology; D005723:gamma-Glutamyltransferase / Q000378:metabolism; D004124:p-Dimethylaminoazobenzene
D004224:Diterpenes; D000084562:Retinyl Esters; D012794:Sialic Acids; D014801:Vitamin A; C009166:retinol acetate; D008749:Methyldimethylaminoazobenzene; D004124:p-Dimethylaminoazobenzene; D005723:gamma-Glutamyltransferase; D000264:Adenylosuccinate Lyase; D019158:N-Acetylneuraminic Acid