The effect of aspartame on the activity of rat liver xenobiotic-metabolizing enzymes.
Male, Wistar rats were administered aspartame (40 or 4000 mg/kg body weight) in their diet for 90 days. By 45 days, the activities of three microsomal enzymes, epoxide hydrolase, carboxylesterase, and p-nitrophenyl-UDP-glucuronosyltransferase, were significantly increased in rats consuming 4000 mg/kg of aspartame. By 90 days, however, the activity of the xenobiotic-metabolizing enzymes of the rats given aspartame did not differ significantly from the activity of control animals. From these results, we conclude that the consumption of aspartame does not substantially alter the function of the hepatic microsomal enzymes which protect the organism from foreign compounds found in its environment and food.
Tutelyan
V A
VA
Institute of Nutrition, USSR Academy of Medical Sciences, Moscow.
Kravchenko
L V
LV
Kuzmina
E E
EE
D000818:Animals; D001218:Aspartame / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004032:Diet; D004151:Dipeptides / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D015262:Xenobiotics / Q000378:metabolism*
D004151:Dipeptides; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001218:Aspartame