Origin of chromosome rearrangements in two long-lived human keratinocyte lines.
We have determined the origin of the extra chromosomal material in the karyotypes of two spontaneously-occurring long-lived human keratinocyte lines, HKC-N2 and HKC-N6. In each case the extra material was derived from the chromosome on which it was located. Possible relationships between the triplication of chromosomal material and the overcoming of cell senescence are discussed.
Rosenberg
C
C
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Stetten
G
G
Kearns
W G
WG
Pearson
P L
PL
Littlefield
J W
JW
D002460:Cell Line; D002887:Chromosomes, Human, Pair 18; D002899:Chromosomes, Human, Pair 9; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D015321:Gene Rearrangement; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology*; D009693:Nucleic Acid Hybridization; D014314:Trisomy
D015342:DNA Probes; D004247:DNA