[The effect of opiate receptor agonists on the blood circulation in rats with hemorrhagic shock].
The effect of intravenous infusion of agonists of mu-(DAGO) and delta-(DADL, DAAE) opiate receptors on mean arterial pressure and heart rate was studied in experiments on rats with dosed blood loss of up to 30% of calculated blood volume. Stimulation of mu-opiate receptors inhibited the drop of mean arterial pressure in hemorrhagic shock, whereas stimulation of delta-opiate receptors failed to produce such an effect. Preliminary injection of naloxone blocked the effects of mu-receptor stimulation.
Slepushkin
V D
VD
Grossler
Iu
Iu
Sheĭkh
D V
DV
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D016308:Enkephalin, Leucine-2-Alanine / Q000627:therapeutic use*; D004745:Enkephalins / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects*; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000503:physiopathology
D004745:Enkephalins; D011957:Receptors, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D016308:Enkephalin, Leucine-2-Alanine
Vliianie agonistov opiatnykh retseptorov na krovoobrashchenie u krys s gemorragicheskim shokom.