title: Study of a dose-dependent effect of the glycosaminoglycan polysulfate on various parameters of blood coagulation.
abstract: In a double-blind study the dose-dependent effect of 10, 20, 40, and 70 mg of SSHA was tested in volunteers. Whereas only a minor prolongation of the aPTT was noted, a clear anti-factor Xa effect was proven (method of Yin), as well as the release of lipoprotein lipase. In a subsequent study, 12 volunteers were treated daily with a dose of 40 mg for 11 days. On the first day of treatment a dosage of 40 mg SC was administered three times every 90 min. There was no cumulative effect with this dose and a clear plateau effect was recorded daily after each application. Repeated administration therefore results in an identical reproducible effect. Thus, no tachyphylaxis occurred under long-term treatment with 40 mg SSHA.
authors.affiliation: Institut für Experimentelle Chirurgie der Technischen Universität München, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Haas
authors.forename: A W
authors.initials: AW
authors.lastname: Stemberger
authors.forename: H M
authors.initials: HM
authors.lastname: Fritsche
authors.forename: P
authors.initials: P
authors.lastname: Wendt
authors.forename: G
authors.initials: G
authors.lastname: Blümel
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D002809:Chondroitin Sulfates / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D065427:Factor Xa Inhibitors; D006801:Humans; D007279:Injections, Subcutaneous; D008071:Lipoprotein Lipase / Q000097:blood; D008297:Male
chemical_list: D065427:Factor Xa Inhibitors; C026210:SSHA; D002809:Chondroitin Sulfates; D008071:Lipoprotein Lipase