[Pathospermia in patients with glomerulonephritis and rheumatoid arthritis treated by immunodepressants: the possibilities of its correction with zinc and parlodel].
Two groups of patients aged 16.5-31 years with pathospermia given immunodepressants (IDS) for glomerulonephritis (group I) or rheumatoid arthritis (group II) before and/or at the moment of examination were examined. Five out of 6 patients of group I and all the patients of group II showed azoospermia. As a result of the treatment with zinc (30-90 mg of elementary zinc a day) and parlodel (2.5 mg/day) for 2-23 months, spermatogenesis improved or returned to normal in 2 patients of group I and in 2 patients of group II. It should be mentioned that out of 8 patients who turned out refractory to the treatment, 7 received glucocorticoids and cytostatics (CT) whereas among those who responded to the treatment, only 2 patients out of 4 were given CT. The reported data on the gonadotoxic dose of CT are discussed. The conclusion is made about the necessity of carrying out active treatment policy for pathospermia in patients who received IDS.
Kukhtevich
A V
AV
Ermolenko
V M
VM
Bunatian
A F
AF
Gitel'
E P
EP
Smirnov
G A
GA
Nosova
A A
AA
Obydena
E A
EA
D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D001971:Bromocriptine / Q000627:therapeutic use*; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D005921:Glomerulonephritis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D009845:Oligospermia / Q000139:chemically induced* / Q000188:drug therapy; D013076:Sperm Count / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013997:Time Factors; D015032:Zinc / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D001971:Bromocriptine; D015032:Zinc
Patospermiia u bol'nykh glomerulonefritom i revmatoidnym artritom, lechivshikhsia immunodepressantami: vozmozhnosti korrektsii tsinkom i parlodelom.