Bone-marrow transplant from father to son and subsequent graft from son to father.
An 11-year-old boy with acute myeloblastic leukaemia in first remission received an allogeneic mismatched bone-marrow transplant (BMT) from his father in 1979; subsequent HLA typing showed that his haemopoietic system had been repopulated by the donor cells. In 1986 hypereosinophilic syndrome, secondary to a T-cell lymphocytic lymphoma, developed in the father, then aged 45 years. A full haematological remission was obtained by means of standard acute lymphoblastic leukaemia treatment. He then received melphalan, total body irradiation, and a BMT from his son. Graft-versus-host disease was transient in both patients, and father and son remain well and disease-free 20 months and 10 years, respectively, after BMT.
Powles
R L
RL
Leukaemia Unit, Royal Marsden Hospital, Sutton, Surrey, UK.
Parikh
P M
PM
Helenglass
G
G
Aboud
H H
HH
Smith
C L
CL
Mrazek
I A
IA
Shepherd
V
V
Milliken
S T
ST
Treleaven
J
J
Sharrock
C
C
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002648:Child; D003131:Combined Modality Therapy; D004802:Eosinophilia / Q000209:etiology / Q000601:surgery; D005069:Evaluation Studies as Topic; D005190:Family; D005192:Family Health; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology; D006650:Histocompatibility Testing; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D008223:Lymphoma / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012074:Remission Induction / Q000379:methods; D012086:Reoperation; D013601:T-Lymphocytes; D013997:Time Factors