title: Gender and age differences in the growth hormone response to pyridostigmine.
abstract: Thirty healthy subjects 12 males and 18 females were given the acetylcholinesterase inhibitor pyridostigmine (120 mg) orally. The growth hormone (GH) response was measured as the maximum GH level post-pyridostigmine relative to baseline. Twenty-six subjects increased their GH level in response to pyridostigmine. Responses in females were considerably greater than those in males and correlated closely with serum oestradiol levels. Overall there was a significant negative correlation between GH response and age.
authors.affiliation: Department of Psychiatry, Trinity College, Medical School, St. James' Hospital, Dublin, Eire.
authors.forename: J V
authors.initials: JV
authors.lastname: Lucey
authors.forename: V
authors.initials: V
authors.lastname: O'Keane
authors.forename: K
authors.initials: K
authors.lastname: O'Flynn
authors.forename: A W
authors.initials: AW
authors.lastname: Clare
authors.forename: T G
authors.initials: TG
authors.lastname: Dinan
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D012016:Reference Values; D012737:Sex Factors
chemical_list: D013006:Growth Hormone; D011729:Pyridostigmine Bromide