title: Extent, distribution, and mammographic/histological correlations of breast ductal carcinoma in situ.
abstract: To assess the potential of breast-conserving treatment for ductal carcinoma in situ (DCIS), 82 mastectomy specimens were studied by Egan's serial subgross method. 42 (51%) of the tumours were larger than 50 mm and only 12 (15%) were smaller than 20 mm; the size distribution was not affected by the mode of detection (mammography 52 cases, clinical examination 30). All but 1 case showed only 1 region of tumour. 66% of tumours involved one breast quadrant, 23% extended over more than one quadrant, and 11% were centrally located. Mammographic estimates, based on the extent of microcalcifications, frequently underestimated the histological size of tumours, the extent of the discrepancy being related to the histological type--8/50 predominantly micropapillary/cribriform. In view of the frequently large size, adequate excision of many DCIS will require a wide excision involving up to a whole quadrant.
authors.affiliation: Department of Pathology, Radboud University Hospital, Nijmegen, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Holland
authors.forename: J H
authors.initials: JH
authors.lastname: Hendriks
authors.forename: A L
authors.initials: AL
authors.lastname: Vebeek
authors.forename: M
authors.initials: M
authors.lastname: Mravunac
authors.forename: J H
authors.initials: JH
authors.lastname: Schuurmans Stekhoven
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods; D008408:Mastectomy; D009367:Neoplasm Staging; D012189:Retrospective Studies