title: [Hydroxyapatite/collagen. Experimental study of its application in facial surgery and report of a case].
abstract: A new implant made of purified fibrillar collagen (P.F.C.) and hydroxylapatite particles (HA) (Maxill-HAPR) is tested in canine mandibulae and surrounding tissues so that its integration and its bone-induction capacity can be histologically studied. A clinical case is also reported. The goal of this combined implant is to improve the interface of the HA particles with the host-tissues through the P.F.C. This study shows that P.F.C. is replaced after two months by host fibro-conjunctive tissues. Between 3 and 4 months, ossification areas are observed. After 6 months, the host conjunctive tissue is replaced by bone surrounding the HA particles. P.F.C.-HA implants can be made for replacement or restoration of facial bones not submitted to important forces like the frontal or malar bones.
authors.affiliation: Service ORL et Chirurgie Cervico-faciale, Cliniques de l'Université de Louvain, Belgique.
authors.forename: M
authors.initials: M
authors.lastname: Remacle
authors.forename: E
authors.initials: E
authors.lastname: Marbaix
authors.forename: V
authors.initials: V
authors.lastname: Mustin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001845:Bone Cysts / Q000601:surgery; D003094:Collagen / Q000008:administration & dosage*; D004285:Dogs; D017886:Durapatite; D006801:Humans; D006882:Hydroxyapatites / Q000008:administration & dosage*; D008297:Male; D008334:Mandible / Q000166:cytology / Q000601:surgery*; D008336:Mandibular Diseases / Q000601:surgery; D008875:Middle Aged; D019736:Prostheses and Implants
chemical_list: D001672:Biocompatible Materials; D006882:Hydroxyapatites; D003094:Collagen; D017886:Durapatite
vernacular_title: Hydroxylapatite/collagène. Etude expérimentale pour son application en chirurgie faciale et rapport d'un cas.