title: Autosomal dominant atrial septal defect of ostium secundum type. Report of three families.
abstract: The authors report on three Sicilian families with 17 individuals (10 females and 7 males) in successive generations affected by atrial septal defect of ostium secundum type (S-ASD) without conduction defect. The anomaly was inherited as an autosomal dominant trait. Cytoplasmic inheritance could be excluded, the anomaly being transmitted also by fathers. Familial S-ASD is probably more frequent than commonly reported since cardiological examination of the relatives is not routinely performed in every case of apparently sporadic ASD.
authors.affiliation: Institutes of Pediatric Department, University of Catania, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Li Volti
authors.forename: G
authors.initials: G
authors.lastname: Distefano
authors.forename: R
authors.initials: R
authors.lastname: Garozzo
authors.forename: M G
authors.initials: MG
authors.lastname: Romeo
authors.forename: P
authors.initials: P
authors.lastname: Sciacca
authors.forename: F
authors.initials: F
authors.lastname: Mollica
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005799:Genes, Dominant; D006337:Heart Murmurs / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D006344:Heart Septal Defects, Atrial / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012802:Sicily