[Expression of EGF receptor and c-neu oncogene product in chordomas].
The expression of EGF receptor, c-neu oncogene product, and of transferrin receptor in 13 cases of chordomas (9 without metastasis and 4 with metastasis) was examined immunohistologically by the B-SA method using specific antibodies to these proteins. Tumor cells in 5 cases without metastasis and 3 cases with metastasis were positive for EGF receptor, those in 7 cases without metastasis and all cases with metastasis were positive for c-neu product, while those in all cases were negative for transferrin receptor. These results suggest a possible link between the expression of cellular genes associated with the growth of neuroectodermal cells and the growth of chordoma known to arise from the embryonal rest of the notochord.
Tamayama
C
C
Dept. of Pathology, Chiba Cancer Center Research Institute.
Maruyama
K
K
D000328:Adult; D000368:Aged; D002817:Chordoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D011519:Proto-Oncogenes; D018719:Erb-b2 Receptor Tyrosine Kinases; D011990:Receptors, Transferrin / Q000378:metabolism
D066246:ErbB Receptors; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011990:Receptors, Transferrin