Vitamin E deficiency has a pathological role in myocytolysis in cardiomyopathic Syrian hamster (BIO14.6).
This study revealed the occurrence of vitamin E deficiency in the myocardium of 60-day-old Syrian cardiomyopathic hamsters (BIO14.6), and that this deficiency might be related to the increase in lipid peroxide. Vitamin E administration for ten days effectively restored creatininekinase activity and decreased the lipid peroxide content in the myocardium, returning these to normal control levels (F1b). These results indicate that vitamin E deficiency, possibly combined with oxidative stress in the early cardiomyopathic stage plays an important role in initiating the pathogenesis of myocardial lesions.
Sakanashi
T
T
3rd Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.
Sako
S
S
Nozuhara
A
A
Adachi
K
K
Okamoto
T
T
Koga
Y
Y
Toshima
H
H
D000818:Animals; D009202:Cardiomyopathies / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D006224:Cricetinae; D006321:Heart / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D012016:Reference Values; D014810:Vitamin E / Q000378:metabolism / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000188:drug therapy / Q000503:physiopathology*
D008054:Lipid Peroxides; D014810:Vitamin E