Sinus disease in patients with severe cystic fibrosis: relation to pulmonary exacerbation.
Four adult cystic fibrosis patients were selected for aggressive surgical management of sinus disease on the basis of severe pulmonary involvement, high frequency of hospital admission, chronic headache, and wheezing unresponsive to conventional treatment. They underwent bilateral Caldwell-Luc procedure with perioperative anti-Pseudomonas antimicrobials. There were substantial improvements in headache and respiratory symptoms and a significant reduction in the frequency of hospital admission after the operation. These findings suggest that sinus disease is associated with pulmonary exacerbation in patients with cystic fibrosis, and strengthens a similar observation in patients with asthma.
Umetsu
D T
DT
Department of Pediatrics, Stanford University School of Medicine, California.
Moss
R B
RB
King
V V
VV
Lewiston
N J
NJ
D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D003550:Cystic Fibrosis / Q000150:complications* / Q000503:physiopathology; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D010254:Paranasal Sinus Diseases / Q000150:complications* / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D010865:Pilot Projects; D011552:Pseudomonas Infections / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D012140:Respiratory Tract Diseases / Q000209:etiology* / Q000503:physiopathology; D012720:Severity of Illness Index; D014797:Vital Capacity