title: [Immunomodulating effect of LongoVital in patients with recurrent aphthous stomatitis. 2].
abstract: LongoVital (LV) (DK. reg. no. 5178/75) is a herbal-based tablet enriched with recommended doses of vitamins. Peripheral lymphocyte subsets: T-helper/CD4 (OKT4+) and T-suppressor/cytotoxic/CD8 (OKT8+) were studied quantitatively in 31 otherwise healthy patients with minor recurrent aphthous ulceration (RAU) during six months' daily LV intake in a double-blind, randomised, crossover 1-year study. Fourteen had had LV during the first six months (GrA) and 17 LV during the latter six months (GrB). OKT4+ percentages increased significantly during the LV period in both groups (p less than 0.05). OKT8+ percentages increased in both groups, however, only significantly in GrA (P less than 0.05). It is concluded that LV acts as an immunostimulator in patients with RAU and that the increase in T-lymphocyte subsets may account for the previously reported benefit of LV in RAU prevention.
authors.affiliation: Afdeling for tand-, mund- og kaebesygdomme og vaevsty-pelaboratoriet, Rigshospitalet, København.
authors.forename: A
authors.initials: A
authors.lastname: Pedersen
authors.forename: B
authors.initials: B
authors.lastname: Klausen
authors.forename: H P
authors.initials: HP
authors.lastname: Hougen
authors.forename: L
authors.initials: L
authors.lastname: Ryder
authors.forename: K
authors.initials: K
authors.lastname: Winther
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000276:immunology* / Q000517:prevention & control; D013601:T-Lymphocytes / Q000276:immunology; D013607:Tablets; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D010936:Plant Extracts; D013607:Tablets; D014815:Vitamins
vernacular_title: Immunmodulerende effekt af LongoVital hos patienter med recidiverende aftøs stomatit. 2.