title: Phenprocoumon-induced hepatitis mimicking non-A, non-B hepatitis.
abstract: A 58-year-old man presented with jaundice 6 months after aortic valve replacement. Although non-A, non-B hepatitis was initially suspected, the final diagnosis of phenprocoumon (Marcoumar)-induced hepatitis progressing to cirrhosis was based on recurrence of jaundice after re-exposure to the drug, improvement after withdrawal and centrilobular necrosis with eosinophilic infiltration in the liver biopsy. Antibodies to hepatitis C virus were absent. The aortic valve was replaced by a bioprosthesis to eliminate the need for life-long anticoagulation.
authors.affiliation: Department of Internal Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands.
authors.forename: R A
authors.initials: RA
authors.lastname: de Man
authors.forename: J H
authors.initials: JH
authors.lastname: Wilson
authors.forename: S W
authors.initials: SW
authors.lastname: Schalm
authors.forename: F J
authors.initials: FJ
authors.lastname: ten Kate
authors.forename: E
authors.initials: E
authors.lastname: van Leer
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D003937:Diagnosis, Differential; D016174:Hepacivirus / Q000276:immunology; D006526:Hepatitis C / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010644:Phenprocoumon / Q000009:adverse effects* / Q000627:therapeutic use; D013923:Thromboembolism / Q000188:drug therapy
chemical_list: D000914:Antibodies, Viral; D010644:Phenprocoumon