title: [Use of a low dose prostaglandin F2 alpha in bitches].
abstract: The dosage of Prostaglandin F2 alpha used until the present (100, 250 and 1000 micrograms/kg bw), in order to treat pyometra in the bitch, was accompanied with side effects such as salivation, vomiting and diarrhea. In the present work, the efficiency of low dose Prostaglandin (20 micrograms/kg bw) was examined in two different groups of patients: Group 1: Included 9 bitches pregnant for a period of 5-7 weeks duration. Initially the bitches were treated 3 or 4 times per day with Prostaglandin F2 alpha. In these cases abortion took place within 4 to 11 days. Group 2: 12 dogs, suffering from pyometra, were treated 3 times per day with PGF2 alpha for 8 days. In 9 dogs the pyometra resolved and the bitches came in estrus 2-5 months after treatment. 7 bitches have been mated and 6 of these gave birth to healthy litters. During a follow-up period of at least 10 months there has not been a reoccurrence of pyometra. In 3 out of the 12 dogs the uteri were still enlarged after 8 days of treatment. These bitches underwent ovariohysterectomy and a cystic hyperplasia of the endometrium was diagnosed histologically. The low dose (20 micrograms/kg BW) Prostaglandin F2 alpha induced in all dogs the expulsion of the uterine contents. Side effects during the treatment were not observed.
authors.affiliation: Klinik für Geburtshilfe, Jungtier- und Euterkrankheiten, Universität Zürich.
authors.forename: M
authors.initials: M
authors.lastname: Hubler
authors.forename: S
authors.initials: S
authors.lastname: Arnold
authors.forename: M
authors.initials: M
authors.lastname: Casal
authors.forename: M
authors.initials: M
authors.lastname: Flückiger
authors.forename: B
authors.initials: B
authors.lastname: Hauser
authors.forename: L
authors.initials: L
authors.lastname: Corboz
authors.forename: P
authors.initials: P
authors.lastname: Rüsch
mesh_terms: D000028:Abortion, Induced / Q000662:veterinary*; D000818:Animals; D015237:Dinoprost / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D014591:Uterine Diseases / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D015237:Dinoprost
vernacular_title: Anwendung von niedrig dosiertem Prostaglandin F2 alpha bei Hündinnen.