The hepatic microcirculation in experimental cirrhosis. A scanning electron microscopy study of microcorrosion casts.
The experimental model of liver cirrhosis induced by intragastric administration of CCl4 reproduces not only the histological picture of the postnecrotic cirrhosis but also its pathophysiological features. Corrosion casts of livers affected by CCl4-induced cirrhosis show the loss of the lobular pattern. Once the cirrhosis has completely developed, the whole microvascular bed appears to be composed of groups of sinusoid nodules of diameters varying between 0.3 and 1.5 mm.. Pre- and post-sinusoidal vessels and anastomoses between the former and the latter are mainly located at the perinodular spaces. This microvascular situation modifies the normal perfusion gradient within the parenchyma. Nevertheless, it can allow a still viable function.
Gaudio
E
E
Dept. of Experimental Medicine, Human Anatomy, State University of L'Aquila.
Pannarale
L
L
Ripani
M
M
Onori
P
P
Riggio
O
O
D000818:Animals; D002251:Carbon Tetrachloride; D016319:Corrosion Casting / Q000379:methods*; D004195:Disease Models, Animal; D008099:Liver / Q000098:blood supply / Q000648:ultrastructure*; D008106:Liver Cirrhosis, Experimental / Q000473:pathology*; D008297:Male; D008833:Microcirculation; D008855:Microscopy, Electron, Scanning; D051381:Rats; D011919:Rats, Inbred Strains
D002251:Carbon Tetrachloride