title: Synthesis and anticonvulsant activity of some benzopyranone imino derivatives of GABA and related compounds.
abstract: The synthesis of some 5-hydroxy-4-imino-2,3-dihydrobenzopyran derivatives of GABA and alkylamines is described. The products were tested for their GABA-receptor binding and anticonvulsant activity in mice. Some compounds showed anticonvulsant activity. No binding to GABA receptors was observed.
authors.affiliation: Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano.
authors.forename: A
authors.initials: A
authors.lastname: Arnoldi
authors.forename: L
authors.initials: L
authors.lastname: Merlini
authors.forename: M L
authors.initials: ML
authors.lastname: Quadri
authors.forename: A
authors.initials: A
authors.lastname: Bonsignori
authors.forename: P
authors.initials: P
authors.lastname: Melloni
authors.forename: M
authors.initials: M
authors.lastname: Varasi
mesh_terms: D015097:3-Mercaptopropionic Acid / Q000037:antagonists & inhibitors; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D001640:Bicuculline / Q000037:antagonists & inhibitors; D002839:Chromans / Q000138:chemical synthesis* / Q000494:pharmacology; D007097:Imines / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010852:Picrotoxin / Q000037:antagonists & inhibitors; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D015097:3-Mercaptopropionic Acid; D000927:Anticonvulsants; D001640:Bicuculline; D002839:Chromans; D007097:Imines; D010433:Pentylenetetrazole; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid