title: A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.
abstract: The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.
authors.affiliation: Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892.
authors.forename: M H
authors.initials: MH
authors.lastname: Rosner
authors.forename: M A
authors.initials: MA
authors.lastname: Vigano
authors.forename: K
authors.initials: K
authors.lastname: Ozato
authors.forename: P M
authors.initials: PM
authors.lastname: Timmons
authors.forename: F
authors.initials: F
authors.lastname: Poirier
authors.forename: P W
authors.initials: PW
authors.lastname: Rigby
authors.forename: L M
authors.initials: LM
authors.lastname: Staudt
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000235:genetics*; D015536:Down-Regulation; D004622:Embryo, Mammalian / Q000378:metabolism*; D004625:Embryo, Nonmammalian; D004707:Endoderm / Q000166:cytology; D015870:Gene Expression; D005801:Genes, Homeobox; D005854:Germ Cells / Q000378:metabolism*; D008648:Mesoderm / Q000166:cytology; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D050814:Octamer Transcription Factor-3; D009865:Oocytes / Q000254:growth & development / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D013234:Stem Cells / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D050814:Octamer Transcription Factor-3; D012333:RNA, Messenger; D014157:Transcription Factors