Hemodynamic responses to gram-positive versus gram-negative sepsis in critically ill patients with and without circulatory shock.
OBJECTIVE
To examine the hemodynamic patterns of critically ill patients with septicemia to evaluate their relationship to blood bacteriology.


METHODS
Retrospective study.


METHODS
Medical ICUs of a tertiary care medical center.


METHODS
Total of 59 critically ill patients with bacteremia: 33 with Gram-positive and 26 with Gram-negative bacteremia.


METHODS
Hemodynamic variables and mixed venous oxygen saturation (SvO2) measurements associated with the highest cardiac index measured within 72 hrs of positive blood cultures.


RESULTS
No significant differences in cardiac index, mean arterial pressure, systemic vascular resistance, oxygen extraction ratio, or SvO2 were observed comparing the two groups.


CONCLUSIONS
We were unable to demonstrate clinically important differences between the hemodynamic responses to Gram-positive vs. Gram-negative sepsis.
Ahmed
A J
AJ
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI.
Kruse
J A
JA
Haupt
M T
MT
Chandrasekar
P H
PH
Carlson
R W
RW
D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D016638:Critical Illness; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D016908:Gram-Positive Bacterial Infections / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D006439:Hemodynamics; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D014655:Vascular Resistance
D010100:Oxygen