An NcoI restriction fragment length polymorphism at the human steroid sulphatase gene locus.
The DNA diagnosis of X-linked recessive ichthyosis vulgaris (incidence: approx. 1 in 5000 males) can be complicated by the absence of restriction fragment length polymorphisms (RFLPs) in the STS (steroid sulphatase) gene. An RFLP sequence in NcoI-digested genomic DNA is reported, which it is hoped may prove helpful in diagnosis.
van Zandvoort
P M
PM
Department of Human Genetics, University Hospital of Nijmegen, The Netherlands.
van Bennekom
C A
CA
Ropers
H H
HH
van Oost
B A
BA
D001192:Arylsulfatases / Q000235:genetics*; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000235:genetics*
C052380:endodeoxyribonuclease NcoI; D015252:Deoxyribonucleases, Type II Site-Specific; D013429:Sulfatases; D001192:Arylsulfatases; D043266:Steryl-Sulfatase