Tissue distribution and urinary excretion of 14C-ethion in goats.
Tissue concentration and elimination and urinary excretion were followed after intravenous injection of 14C-ethion in 12 goats. Tissue levels were determined in two goats after 8 hr and on each of days 1, 3, 7, 14 and 28 after exposure. During the four-week period plasma and all tissues examined (liver, kidney, fat, muscle, lung, heart and brain) had detectable 14C-residues, the highest values being found in liver, kidney and fat. Elimination of 14C-residues was faster in the first 3 days than in the later part of the experiment, where the elimination half-life for most tissues was approximately 2 weeks. During the first two weeks after exposure, 77% of the administered dose was eliminated in urine (55%) and faeces (22%). TLC of urine collected over the first 15 hr after exposure showed at least 8 bands of metabolites, five of which accounted for about two thirds of the dose excreted in urine.
Mosha
R D
RD
Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002855:Chromatography, Thin Layer; D005243:Feces / Q000737:chemistry; D005260:Female; D006041:Goats; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D009946:Organothiophosphorus Compounds / Q000493:pharmacokinetics* / Q000652:urine; D014018:Tissue Distribution
D009946:Organothiophosphorus Compounds; D002245:Carbon Dioxide; C100038:ethion