title: 3-Aminotriazole is a substrate for lactoperoxidase but not for catalase.
abstract: Rapid scan spectrophotometry has been applied to investigate the reaction of 3-aminotriazole with mammalian heme enzymes, represented by lactoperoxidase and bovine liver catalase. The results clearly indicate that 3-aminotriazole is a substrate for lactoperoxidase compounds I, II and III, but it does not convert catalase compound I to II under conditions favoring peroxidatic activity of the enzyme. The possible physiological significance of these findings is discussed.
authors.affiliation: Department of Chemistry, University of Alberta, Edmonton, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Metodiewa
authors.forename: H B
authors.initials: HB
authors.lastname: Dunford
mesh_terms: D000640:Amitrole / Q000378:metabolism*; D000818:Animals; D002374:Catalase / Q000378:metabolism*; D002417:Cattle; D007700:Kinetics; D007784:Lactoperoxidase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D013053:Spectrophotometry / Q000379:methods; D013379:Substrate Specificity
chemical_list: D007784:Lactoperoxidase; D002374:Catalase; D000640:Amitrole