Intestinal bacterial origin of D-alanine in urine of mutant mice lacking D-amino-acid oxidase.
Urine from mutant mice which lack D-amino-acid oxidase contained a large amount of D-alanine. The alanine content was not changed by changes in the dietary composition or by starvation. However, oral administration of an antibiotic, amoxicillin, decreased the urinary alanine to the normal level. These results suggest that the D-alanine is not of dietary origin but of intestinal bacterial origin.
Konno
R
R
Department of Microbiology, Dokkyo University School of Medicine, Tochigi, Japan.
Niwa
A
A
Yasumura
Y
Y
D000409:Alanine / Q000378:metabolism / Q000652:urine*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003605:D-Amino-Acid Oxidase / Q000502:physiology*; D004032:Diet; D004755:Enterobacteriaceae / Q000187:drug effects / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*; D008715:Methionine / Q000378:metabolism / Q000652:urine; D051379:Mice; D008817:Mice, Mutant Strains; D013217:Starvation
D000900:Anti-Bacterial Agents; D008715:Methionine; D003605:D-Amino-Acid Oxidase; D000409:Alanine