Effect of particle shape on the mixing of powders.
Mixtures were prepared containing 200 g of 600 microns lactose and 0.5 g of 3 microns calcium carbonate of different particle shapes using a Y cone mixer. Measurements were made of the time required to achieve the acceptable standard deviation of mixing sigma A and of the segregation that occurred on subsequently vibrating the mixtures. The time taken to achieve sigma A increased with the irregularity of the particles of both components and the mixtures containing irregular particles segregated less on vibration.
Wong
L W
LW
University of London, King's College, Chelsea Department of Pharmacy, UK.
Pilpel
N
N
D002119:Calcium Carbonate; D004339:Drug Compounding; D007785:Lactose; D010316:Particle Size; D011208:Powders; D013718:Tensile Strength
D011208:Powders; D002119:Calcium Carbonate; D007785:Lactose