title: [Amplifying sequences in the Streptomyces coelicolor A3 (2) gene].
abstract: The unstable feature of ristomycin resistance in S. coelicolor A3 (2) was studied. It was shown that the frequency of ristomycin-resistant derivatives was high in both chloramphenicol sensitive mutants and their resistant revertants. The 15- and 20-kb DNA sequences capable of amplifying were detected in the chloramphenicol resistant revertants. In the genomes of the studied strains they were represented by 50 and 40 copies, respectively.
authors.forename: S A
authors.initials: SA
authors.lastname: Zavorotnaia
authors.forename: V A
authors.initials: VA
authors.lastname: Fedorenko
authors.forename: L I
authors.initials: LI
authors.lastname: Starodubtseva
authors.forename: V N
authors.initials: VN
authors.lastname: Danilenko
mesh_terms: D002701:Chloramphenicol / Q000494:pharmacology; D002702:Chloramphenicol Resistance / Q000235:genetics; D003470:Culture Media; D004269:DNA, Bacterial / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics; D005784:Gene Amplification / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics*; D066298:In Vitro Techniques; D009154:Mutation / Q000235:genetics*; D012310:Ristocetin / Q000494:pharmacology; D013302:Streptomyces / Q000187:drug effects / Q000235:genetics*
chemical_list: D003470:Culture Media; D004269:DNA, Bacterial; D012310:Ristocetin; D002701:Chloramphenicol
vernacular_title: Amplifitsiruiushchiesia posledovatel'nosti v genome Streptomyces coelicolor A3 (2).