[Transdermal estrogen treatment. A placebo controlled study].
A double blind, crossover study was used to test the effect of transdermal oestrogen therapy (Estraderm) in 22 women with climacteric complaints. The number and intensity of hot flushes were both reduced by approximately 80% (p less than 0.0025). Some improvement was also seen as regards general wellbeing, disturbed sleep and tiredness. We noted a significant increase in serum oestradiol to premenopausal follicular phase levels, and a decrease in FSH values. Systolic blood pressure was lowered during active treatment (p less than 0.025), a smaller reduction of diastolic pressure was not significant. Body weight remained unchanged. Some patients reported tender breasts, and some reported slight irritation of the skin. Neither condition necessitated withdrawal of treatment. It is concluded that Estraderm is effective and suitable for treatment of climacteric complaints.
Iversen
O E
OE
Kvinneklinikken, Haukeland sykehus, Bergen.
Eid
A B
AB
Johannesen
K H
KH
Nyland
B
B
Løvset
T
T
D000279:Administration, Cutaneous; D002979:Climacteric / Q000097:blood / Q000187:drug effects*; D004311:Double-Blind Method; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010919:Placebos; D011446:Prospective Studies
D010919:Placebos; D004958:Estradiol
Transdermal østrogenbehandling. En placebokontrollert studie.