Anthracycline metabolites from Streptomyces violaceus A262. III. New anthracycline obelmycins produced by a variant strain SE2-2385.
New anthracycline antibiotics, designated as obelmycins A, D, E, F and G, were isolated from the culture broth of a variant strain of beta-rhodomycin-producing Streptomyces violaceus A262, identified as beta-isorhodomycinone glycosides and gamma-isorhodomycinone glycosides and assayed for their in vitro cytotoxicities against murine leukemic L1210 cell culture and the antimicrobial activities in comparison with some known anthracyclines.
Johdo
O
O
Central Research Laboratories, Mercian Corporation, Fujisawa, Japan.
Watanabe
Y
Y
Ishikura
T
T
Yoshimoto
A
A
Naganawa
H
H
Sawa
T
T
Takeuchi
T
T
D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013302:Streptomyces / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C071806:obelmycin D; C071805:obelmycin A; C071809:obelmycin G; C071807:obelmycin F; C071808:obelmycin E