Neuropsychological deficits accompanying striatonigral degeneration.
This study presents a structural and functional description of a case of striatonigral degeneration (SND) and emphasizes neuropsychological findings. The patient, a 55-year-old woman with progressive and relatively intractable rigidity and bradykinesia, particularly of the right side, was studied with brain MR scans and with a wide variety of sensory, motor, and cognitive tests known to be subserved by specific brain regions. T2-weighted MR images revealed curvilinear areas of high signal in the lateral putamen at low magnetic field strength (0.3T) and adjacent regions of marked low signal in the posterior-lateral putamen at high magnetic field (1.5T). High signal changes in the insular cortex were also noted on the high field images. Letter fluency and short-term memory as well as motor speed, strength, and sequencing were selectively impaired. Taken together, the data of this case suggest that structural involvement of the putamen resulted in dysfunctions usually associated with the primary motor cortex and orbitofrontal cortex, while sparing functions of other frontal regions as well as temporal and parietal cortices.
Sullivan
E V
EV
Psychiatry Service, DVA Medical Center, Palo Alto, CA 94304.
De La Paz
R
R
Zipursky
R B
RB
Pfefferbaum
A
A
D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D003071:Cognition / Q000502:physiology*; D003342:Corpus Striatum / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology*; D012677:Sensation / Q000502:physiology*; D013378:Substantia Nigra / Q000503:physiopathology