[Effects of sodium artesunate on electrical properties and Na+,K(+)-ATPase activities of mouse small intestine].
Sodium artesunate (SA), a synthetic derivative of artemisinin first isolated in China, is a water soluble antimalaria used clinically in China. The jejunum of mouse was mounted in Ussing chambers and bathed in NaCl Ringer. There was a potential difference (PD) across the intestinal wall with the serosa being positive. Addition of SA to the mucosal side of the D-glucose (5.5 mmol/L) NaCl Ringer bathing solution, caused a significant decrease in both PD and short circuit current (I(sc)). However, SA had little effect when added to the glucose free Ringer bathing solution. SA 0.1-1.0 mmol/L caused a decrease in Na+,K(+)-ATPase activities in vitro. The results suggest that the inhibitory effect on the electrical properties of mouse jejunum is associated with the inhibition of Na+,K(+)-ATPase activities.
Wang
J Y
JY
Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.
Yuan
L Z
LZ
Wang
M D
MD
D000818:Animals; D037621:Artemisinins; D000077332:Artesunate; D001693:Biological Transport, Active; D004594:Electrophysiology; D005260:Female; D007413:Intestinal Mucosa / Q000201:enzymology; D007583:Jejunum / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D012717:Sesquiterpenes / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; D000254:Sodium-Potassium-Exchanging ATPase