[The role of antioxidants in the action of thyroxine on myocardial functional properties in rats].
In conditions of excessive hormones in the blood, alpha-tocopherol increases the cardiomyocytes antioxidant defence, partially prevents the enhancement of the heart tissue sensitivity to induced peroxide oxidation of lipids, and considerably diminishes disorders in the heart contractile function. Under the same conditions, reduced glutathione no only does not exert its defensive action, but even decreases the heart resistance against hypoxia.
Balashova
T S
TS
Khitrov
N K
NK
Gerasimov
A M
AM
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004347:Drug Interactions; D005978:Glutathione / Q000494:pharmacology; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006980:Hyperthyroidism / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D013599:Systole / Q000187:drug effects / Q000502:physiology; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D005978:Glutathione; D013974:Thyroxine
Rol' antioksidantov v deĭstvii tiroksina na funktsional'nye svoĭstva miokarda u krys.