[Multifactorial experiment on the combined effect of rifampicin and microbial polysaccharide in experimental plague infection].
Multifactorial analysis was applied to the study of the combined effect of rifampicin and a microbial polysaccharide in experimental plague infection. The effect of the antibiotic and immunomodulator was shown to be synergistic. On the basis of the study results polynomial statistic models of the second order were designed and nomograms or equal level lines were plotted which provided optimization of the combined chemo- and immunotherapy.
Nikitin
A V
AV
Makarovskaia
L N
LN
Fomina
I P
IP
Ivanitskaia
L P
LP
Popova
G O
GO
Vinidchenko
N N
NN
Korganov
Ia N
IaN
Gorin
S E
SE
D000818:Animals; D000900:Anti-Bacterial Agents; D003627:Data Interpretation, Statistical; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D051379:Mice; D010930:Plague / Q000188:drug therapy*; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D012240:Rhodococcus; D012293:Rifampin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D011135:Polysaccharides, Bacterial; D012293:Rifampin
Izuchenie v mnogofaktornom ékperimente sochetannogo deĭstviia rifampitsina i polisakharida mikrobnogo proiskhozhdeniia pri éksperimental'noĭ chumnoĭ infektsii.