Mouse bone-marrow response to low doses of whole-body gamma irradiation: induction of micronuclei.
The induction of micronuclei in mouse bone marrow was studied after whole-body exposure to low doses of gamma radiation, ranging from 5 to 75 cGy. Micronuclei were scored at 10 and 30 h after irradiation. A linear dose response was obtained at both postirradiation times. However, the number of micronuclei per 100 nuclei was lower at 30 h than at 10 h, and the dose-response curve for the former had a shallower slope. When fitted to the alpha D + beta D2 model, a negative beta value was obtained. This could be due to division delay, combined with elimination of damaged cells by death at higher doses.
Uma Devi
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P
Department of Radiobiology, Kasturba Medical College, Karnataka, India.
Sharma
A S
AS
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D051379:Mice; D008807:Mice, Inbred BALB C; D015162:Micronucleus Tests; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes