Treatment of postoperative otorrhoea by grafting of mastoid cavities with cultured autologous epidermal cells.
Autologous cultured keratinocyte layers were grafted onto the unepithelialised open mastoid cavities in 8 patients with otorrhoea for 2 to 32 years. All procedures were done on an outpatient basis without anaesthesia, except for local anaesthesia for skin biopsy. The cultured keratinocyte layers adhered well to the bed of granulation tissue lining the mastoid cavity and formed an excellent protective covering of stratified squamous epithelium. All 8 patients have been free from otorrhoea for the 2 to 6 months since grafting.
Premachandra
D J
DJ
Department of ENT Surgery, Kent and Sussex Hospital, Tunbridge Wells, UK.
Woodward
B M
BM
Milton
C M
CM
Sergeant
R J
RJ
Fabre
J W
JW
D000328:Adult; D000368:Aged; D000553:Ambulatory Care / Q000379:methods; D000772:Anesthesia, Local; D001706:Biopsy; D002478:Cells, Cultured; D004427:Ear Diseases / Q000473:pathology / Q000628:therapy*; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D007239:Infections / Q000628:therapy*; D015603:Keratinocytes / Q000637:transplantation*; D008416:Mastoid / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D011183:Postoperative Complications / Q000628:therapy*; D012008:Recurrence; D013997:Time Factors; D014182:Transplantation, Autologous