Synergistic effect of prostaglandin E1 and isosorbide dinitrate in peripheral vascular disease.
Isosorbide dinitrate, which releases nitric oxide in vivo, and prostaglandin E1 synergised in reducing platelet deposition and increasing platelet survival time in patients with peripheral vascular disease.
Sinzinger
H
H
Atherosclerosis Research Group, Vienna, Austria.
Fitscha
P
P
O'Grady
J
J
Rauscha
F
F
Rogatti
W
W
Vane
J R
JR
D000368:Aged; D001161:Arteriosclerosis / Q000097:blood* / Q000150:complications; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010976:Platelet Count / Q000187:drug effects*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D016032:Randomized Controlled Trials as Topic
D010975:Platelet Aggregation Inhibitors; D011458:Prostaglandins E; D007548:Isosorbide Dinitrate