[Production of IL-6 and IL-1 alpha by human corneal epithelial cells].
By using enzyme-linked immunosorbent assay (ELISA), it was demonstrated that cultured human corneal epithelial cells produced interleukin-6 (IL-6) without any stimulation. As lipopolysaccharide (LPS)-stimulation did not induce further production of IL-6 and IL-1 alpha, it was suggested that IL-6 was produced naturally as in the case of IL-1 alpha production which has been previously reported by the author. Production of IL-1 alpha and IL-6 in the human corneal epithelial cells may play a role in amplifying immune responses on the ocular surface.
Sakamoto
S
S
Department of Ophthalmology, School of Medicine, Iwate Medical University, Morioka, Japan.
Inada
K
K
Chiba
K
K
Yoshida
M
M
Tazawa
Y
Y
D000328:Adult; D002478:Cells, Cultured; D003315:Cornea / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000096:biosynthesis*
D007375:Interleukin-1; D015850:Interleukin-6