[The effect of a structural analog of gamma-butyrobetaine, mildronate, [3-2,2,2-trimethylhydrazine)propionate] on dynamic carnitine-dependent metabolism].
Inhibitor of carnitine-dependent metabolism mildronate, 3-(2,2,2-trimethylhydrazinium) propionate, administered into rats at a dose of 200 mg/kg, per os, within 10 days, caused a decrease in concentration of free carnitine and of long-chain acylcarnitine in myocardium as well as contributed to accumulation of free fatty acids in blood serum. Besides, the rate of I-14C-palmitic acid turnover to 14CO2 was decreased in myocardium homogenate. The drug inhibitory effect on carnitine biosynthesis from gamma-butyrobetaine was responsible for the phenomenon observed. Content of the metabolites studied was altered gradually both during treatment of rats with mildronate and after the drug abolition, thus demonstrating an opportunity of gentle influence on carnitine-dependent metabolism by means of the drug treatment and its abolition.
Shutenko
Zh V
ZhV
Priedena
I A
IA
Kalvin'sh
I Ia
IIa
Lukevits
E Ia
EIa
D000818:Animals; D002331:Carnitine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D009206:Myocardium / Q000737:chemistry; D010084:Oxidation-Reduction; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism; D051381:Rats
D005230:Fatty Acids, Nonesterified; D008763:Methylhydrazines; D010169:Palmitic Acids; D019308:Palmitic Acid; C050147:3-(2,2,2-trimethylhydrazine)propionate; D002331:Carnitine
Vozdeĭstvie strukturnogo analoga gamma-butirobetaina mildronata [3-(2,2,2-trimetilgidraziniĭ)propionata] na karnitinzavisimyĭ metabolizm v dinamike.