[A clinico-endoscopic study on cicatrization of lesions and prevention of recurrences in patients with liver cirrhosis and peptic ulcer].
Seventy-four and five cirrhotic patients with acute peptic ulcer were respectively treated with H2-blockers and cytoprotective drugs for 4-6 weeks; after this period 49 (62.2%) healed and 14 (17.7%) did not heal after further 2 months with the same therapy. In order to observe the effectiveness of H2-blockers in preventing peptic ulcer recurrences, 77 cirrhotic patients were followed-up for a mean period of 12 months (range 3-48 months) after ulcer scarring; 51.2% under H2-blockers maintenance treatment and 54.8% who took antiacid in case of need, relapsed. The therapeutical response, as regards short-term treatment in cirrhotic patients, seems not to differ from the usual outcome of the general ulcer population; on the contrary, the relapses, also during a maintenance therapy, appears increased.
Di Mario
F
F
Divisione di Gastroenterologia R. Farini, Università e Ospedale Padova.
Gottardello
L
L
Burra
P
P
Salvagnini
M
M
Dalrì
L
L
Leandro
G
G
Contento
F
F
Torri
A
A
Naccarato
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000517:prevention & control; D012008:Recurrence; D013997:Time Factors; D014945:Wound Healing
D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists
Studio clinico-endoscopico sulla cicatrizzazione della lesione e sulla prevenzione delle recidive in pazienti con cirrosi epatica e malattia ulcerosa.