title: Comparative study of C reactive protein and serum amyloid A protein in experimental inflammation.
abstract: The responses of C reactive protein, measured by radial immunodiffusion and radioimmunoassay, and serum amyloid A protein, measured by radial immunodiffusion, were compared in eight subjects with inflammation induced experimentally by intradermal injection of monosodium urate crystals. A significant increase in serum amyloid A was noted after a lag phase of eight hours, the increase in median concentration at 48 hours being about eightfold. A parallel but less marked increase was found in C reactive protein when measured by radioimmunoassay (fourfold increase in median concentration at 48 hours) after a small but significant decrease during the lag phase. The changes in C reactive protein remained within the reference range and were not detectable by radial immunodiffusion.
authors.affiliation: Department of Chemical Pathology, Bristol Royal Infirmary, United Kingdom.
authors.forename: R E
authors.initials: RE
authors.lastname: Chambers
authors.forename: C W
authors.initials: CW
authors.lastname: Hutton
authors.forename: P A
authors.initials: PA
authors.lastname: Dieppe
authors.forename: J T
authors.initials: JT
authors.lastname: Whicher
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D006801:Humans; D005779:Immunodiffusion; D007249:Inflammation / Q000097:blood* / Q000139:chemically induced; D011863:Radioimmunoassay; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D014527:Uric Acid
chemical_list: D000685:Serum Amyloid A Protein; D014527:Uric Acid; D002097:C-Reactive Protein