Antithrombin III activity is not related to plasma homocysteine concentrations.
Arterial and venous thromboembolic events represent frequent and life-threatening complications in homocystinuric patients and are responsible for their early deaths. Reduced levels of antithrombin III activity in homocystinuric patients have recently been reported. So, high plasma L-homocysteine concentration could play a role in the low antithrombin III activity level. In the present study, we have studied the relationship between total plasma homocysteine and inhibitors of blood coagulation levels in 16 patients with malignancies who received bone marrow grafts. There were no correlations between homocysteine values and inhibitors of blood coagulation levels. So, while the defect in amino acid transsulfuration that is responsible for homocystinuria can directly affect the synthesis or activity of some clotting factors, homocysteine concentration is not responsible for this effect.
Bienvenu
T
T
Laboratoire de Biochimie Génétique, Hôpital Necker-Enfants-Malades, Paris, France.
Chadefaux
B
B
Ankri
A
A
Leblond
V
V
Coude
M
M
Salehian
B
B
Binet
J L
JL
Kamoun
P
P
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism*; D001777:Blood Coagulation / Q000502:physiology*; D016026:Bone Marrow Transplantation / Q000502:physiology*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000601:surgery*; D013923:Thromboembolism / Q000097:blood*
D006710:Homocysteine; D000990:Antithrombin III