Influence of time, type of diet and ursodeoxycholic acid on biliary secretion in rats with intestinal resection.
The effects of time and the type of dietary fat on biliary physiology in rats with 50% resection of the distal small intestine was investigated. The effects of ursodeoxycholic acid as an exogenous source in bile acid added to the diet were also studied. The fat composition of all diets was the same in quantitative terms (4%), and differed only in the type of lipid supplied: olive oil (diet A) or 1/3 medium chain triglycerides, 1/3 sunflower seed oil and 1/3 olive oil (diet B). Three months after intestinal resection, neither group of resected rats showed significant changes in bile flow or bile acid output in comparison to controls, whereas the slope of the regression line was notably increased, indicating that enterohepatic circulation failed to adapt to the different dietary fats during recovery from intestinal resection. The addition of ursodeoxycholic acid to diet B significantly raised bile acid flow and output in comparison to controls, as a result of the recovery of enterohepatic circulation. This was reflected in the lower slope of the regression line, thus suggesting that de novo synthesis in resected animals was less intensely stimulated.
Campos
M S
MS
Department of Physiology, Faculty of Pharmacy, University of Granada, Granada, Spain.
Lisbona
F
F
Coves
F
F
Garcia
J A
JA
Barrionuevo
M
M
López-Aliaga
I
I
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D007421:Intestine, Small / Q000502:physiology* / Q000601:surgery; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014580:Ursodeoxycholic Acid / Q000494:pharmacology*
D001647:Bile Acids and Salts; D004041:Dietary Fats; D014580:Ursodeoxycholic Acid