title: [Collagenase for the treatment of torpid ulcerative lesions of the legs].
abstract: The therapeutic effectiveness and the tolerability of a collagenase-chloramphenicol ointment were studied on a group of 20 patients (mean age 73.4 +/- 13.6 years, range 25-88 years) with lower limb ulcerations of various origin. The ointment proved capable of favourably influencing the debridment and the healing process of these lesions. Statistically significant improvements were observed after days of treatment for debridment, inflammation and granulation, after eight days for the lesion size and after ten days for epithelization. Tolerability was very good.
authors.affiliation: Divisione di Dermatologia, Ospedale Civile, Cremona.
authors.forename: G B
authors.initials: GB
authors.lastname: Lazzari
authors.forename: A M
authors.initials: AM
authors.lastname: Monteverdi
authors.forename: O
authors.initials: O
authors.lastname: Adami
authors.forename: E
authors.initials: E
authors.lastname: Pezzarossa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy*; D008297:Male; D003012:Microbial Collagenase / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D003012:Microbial Collagenase
vernacular_title: La collagenasi nel trattamento delle lesioni ulcerative torpide degli arti inferiori.