Microsomal enzymes in lambs and adult sheep, and their possible relationship to alveld.
The difference in susceptibility to alveld between lambs and adult sheep may be caused by differences in the microsomal enzyme activities in their livers. There was no difference in NADPH-cytochrome c reductase or 7-ethoxyresorufin-O-deethylase (EROD) activity between ewes, control lambs and phenobarbitone-dosed lambs 3 weeks after dosing ceased. However, aldrin epoxidase activity was at that time significantly highest in the phenobarbitone-dosed lambs and significantly lowest in the ewes. The liver cytosolic glutathione transferase activity was significantly highest in the ewes and significantly lowest in the control lambs at the same time.
Flåøyen
A
A
Department of Large Animal Clinical Sciences, Norwegian College of Veterinary Medicine, Oslo.
Jensen
E G
EG
D000818:Animals; D019363:Cytochrome P-450 CYP1A1; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D004198:Disease Susceptibility; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000032:analysis; D009251:NADPH-Ferrihemoprotein Reductase / Q000032:analysis; D010088:Oxidoreductases / Q000032:analysis; D010634:Phenobarbital / Q000494:pharmacology; D010787:Photosensitivity Disorders / Q000150:complications / Q000201:enzymology / Q000662:veterinary*; D010939:Plant Poisoning / Q000150:complications / Q000201:enzymology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000201:enzymology*
D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; C019647:aldrin epoxidase; D019363:Cytochrome P-450 CYP1A1; D009251:NADPH-Ferrihemoprotein Reductase; D005982:Glutathione Transferase; D010634:Phenobarbital