Activity of xenobiotic metabolizing liver enzymes in Zucker rats.
The activity of four liver enzymes participating in the xenobiotic metabolism was determined in male and female obese hyperinsulinemic Zucker rats. When compared to lean normoinsulinemic control animals the obese male rats had lower hepatic aryl hydrocarbon hydroxylase and the female animals lower 7-ethoxycoumarine O-deethylase and N-nitrosodimethylamine N-demethylase activities. The results contrast those reported in the literature for hypoinsulinemic streptozotocin diabetic rats.
Huupponen
R
R
Department of Clinical Pharmacology, University of Turku, Finland.
Pyykkö
K
K
Ala-Uotila
S
S
Sotaniemi
E
E
D015660:7-Alkoxycoumarin O-Dealkylase / Q000378:metabolism*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D006946:Hyperinsulinism / Q000201:enzymology; D008099:Liver / Q000201:enzymology*; D008297:Male; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D009765:Obesity / Q000201:enzymology; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011924:Rats, Zucker
D001786:Blood Glucose; D003577:Cytochrome P-450 Enzyme System; D015660:7-Alkoxycoumarin O-Dealkylase; D019392:Cytochrome P-450 CYP2E1; D001189:Aryl Hydrocarbon Hydroxylases; D010089:Oxidoreductases, N-Demethylating; D009251:NADPH-Ferrihemoprotein Reductase