CD8+ lymphocytes suppress HIV production by autologous CD4+ cells without eliminating the infected cells from culture.
Studies of separated peripheral blood mononuclear cell subsets have indicated that the CD8+ lymphocyte is the primary cell type responsible for suppressing human immunodeficiency virus (HIV) replication by infected CD4+ cells. The effect of this antiviral activity is dose-dependent and does not involve killing of the infected cell. These observations indicate that this response is distinct from the anti-HIV cytotoxic mechanisms also described for human CD8+ cells.
Wiviott
L D
LD
Department of Medicine, University of California, School of Medicine, San Francisco 94143.
Walker
C M
CM
Levy
J A
JA
D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000382:microbiology*; D016827:CD8 Antigens; D002470:Cell Survival; D002478:Cells, Cultured; D006679:HIV Seropositivity / Q000276:immunology*; D015497:HIV-1 / Q000254:growth & development*; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D014779:Virus Replication
D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens