title: Central action of psychomotor stimulants on glucose utilization in extrapyramidal motor areas of the rat brain.
abstract: Psychomotor stimulants increase regional cerebral metabolic rates for glucose (rCMRglc). To determine if effects in motor areas reflect limb movements, we measured rCMRglc in gallamine-paralyzed rats given cocaine, methylenedioxymethamphetamine, amphetamine, or phencyclidine. Results resembled findings in partially immobilized rats. One difference was lack of cocaine-induced stimulation in the caudate-putamen despite an increase in partially immobilized rats. Therefore, stimulant-induced rCMRglc stimulation in most motor areas is a primary CNS effect.
authors.affiliation: Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224.
authors.forename: E D
authors.initials: ED
authors.lastname: London
authors.forename: G
authors.initials: G
authors.lastname: Wilkerson
authors.forename: C
authors.initials: C
authors.lastname: Ori
authors.forename: A S
authors.initials: AS
authors.lastname: Kimes
mesh_terms: D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003042:Cocaine / Q000494:pharmacology*; D015198:Designer Drugs / Q000494:pharmacology; D005947:Glucose / Q000493:pharmacokinetics*; D008297:Male; D009068:Movement / Q000187:drug effects*; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000662:Amphetamines; D015198:Designer Drugs; D015104:3,4-Methylenedioxyamphetamine; D003042:Cocaine; D005947:Glucose; D010622:Phencyclidine; D018817:N-Methyl-3,4-methylenedioxyamphetamine