title: Effects of the immune system on cyclosporine absorption.
abstract: 1. The pharmacokinetics and toxicodynamics of single and multiple doses of cyclosporine were studied in the immunized rat model and compared with non-immunized rats. 2. The pharmacokinetics of cyclosporine i.v. (5 mg/kg per day) were similar in immunized and non-immunized rats after single or multiple doses. 3. The absolute bioavailabilities of single and multiple doses of cyclosporine (10 mg/kg per day) given orally were significantly decreased in immunized rats compared with non-immunized rats. 4. Oral administration of cyclosporine (10 mg/kg per day) did not alter renal function of non-immunized rats compared with untreated controls. However, inulin clearance decreased greater than four-fold in immunized rats given cyclosporine for 7 days. 5. In summary, the pharmacokinetics and toxicodynamics of cyclosporine given orally to rats are affected by the immune system.
authors.affiliation: Department of Pharmaceutics, University of Houston, TX 77030.
authors.forename: D R
authors.initials: DR
authors.lastname: Luke
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D007114:Immunization; D007408:Intestinal Absorption; D008297:Male; D011863:Radioimmunoassay; D051381:Rats
chemical_list: D003524:Cyclosporins