Regulatory functions for murine intraepithelial lymphocytes in mucosal responses.
Our studies have given direct evidence that CD3+, CD4-, CD8+ T cells in the IELs can be separated into at least two subsets that produce IFN-gamma and/or IL-5 and may exhibit Th1- and Th2-type functions in the epithelium and in the underlying lamina propria region. Further, it was also shown that TCR1+ T cells in IELs are capable of producing IFN-gamma and/or IL-5. In addition to production of these cytokines, IELs derived from mice orally primed with TD antigen contain a subset of T cells which possess antigen-specific immunoregulatory function. CD3+, CD4-, CD8+ T cells isolated from IEL of TD antigen-primed mice abrogated systemic unresponsiveness to secondary-type responses including those of the IgA isotype upon adoptive transfer to mice with OT. Our studies further suggested that these CD3+, CD4-, CD8+ IELs use the gamma-delta form of TCR (TCR1) for their immunoregulatory function.
Kiyono
H
H
Department of Oral Biology, University of Alabama, Birmingham.
Fujihashi
K
K
Taguchi
T
T
Aicher
W K
WK
McGhee
J R
JR
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D016207:Cytokines / Q000096:biosynthesis; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D007070:Immunoglobulin A / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D051379:Mice; D011948:Receptors, Antigen, T-Cell
D000945:Antigens, Differentiation, T-Lymphocyte; D016207:Cytokines; D007070:Immunoglobulin A; D011948:Receptors, Antigen, T-Cell