[Selective activation of adrenaline secretion by the rat adrenal in neuroglycopenia detected via microdialysis].
Secretion of adrenaline (A) and noradrenaline (NA) was measured in conscious Wistar rats using the microdialysis probe implanted into the adrenal gland. Changes in contents of A and NA in plasma as well as in dialysate samples in response to i. v. administration of 500 mg/kg 2-deoxy-D-glucose (2-DG) were measured by HPLC with electrochemical detection. 2-DG-induced neuroglycopenia led to a selective increase in adrenal secretion of A which reached maximum 20 m after 2-DG administration, whereas an increase in A and NA contents occurred in plasma. Elevation in the plasma NA content seems to reflect an enhancement in sympathetic nervous activity.
Medvedev
O S
OS
Selivanov
V N
VN
Kuz'min
A I
AI
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000503:physiopathology*; D002908:Chronic Disease; D003847:Deoxyglucose; D003956:Dialysis / Q000295:instrumentation; D004195:Disease Models, Animal; D004837:Epinephrine / Q000032:analysis / Q000378:metabolism*; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology*; D015918:Infusion Pumps, Implantable; D008297:Male; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D003847:Deoxyglucose; D009638:Norepinephrine; D004837:Epinephrine
Izbiratel'naia aktivatsiia sekretsii adrenalina nadpochechnikom krysy pri neĭroglikopenii, obnaruzhivaemaia s pomoshch'iu mikrodializa.