Bone marrow cell populations mimicking common acute lymphoblastic leukemia in infants with stage IV-S neuroblastoma.
Immunophenotyping of bone marrow mononuclear cells of 2 infants with stage IV-S neuroblastoma revealed the presence of many lymphoblasts and immature lymphocytes. Immunophenotyping showed that a high percentage of bone marrow cells were positive for the HLA-DR, CD19, CD20 and CD10 phenotype, similar to common acute lymphoblastic leukemia cells. Within 6 months of follow-up, without any treatment, complete regression of the tumors was observed. The coexistence of these two unusual populations will be discussed.
Mandel
M
M
Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Rechavi
G
G
Neumann
Y
Y
Biniaminov
M
M
Brok-Simoni
F
F
Bojanover
Y
Y
Burstein
Y
Y
Ben-Bassat
I
I
Ramot
B
B
D001853:Bone Marrow / Q000276:immunology / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D008297:Male; D009447:Neuroblastoma / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*