Diamine oxidase activity in a model of multistep hepatocarcinogenesis.
Treatment of rats with a complete hepatocarcinogenic regimen (diethylnitrosamine, 2-acetylaminofluorene and partial hepatectomy) produced a prolonged stimulation of diamine oxidase activity in liver, which showed early and persistent preneoplastic nodules. Diethylnitrosamine or partial hepatectomy tested separately caused a transient increase in enzyme activity. Early nodules, which were positive for gamma-glutamyltransferase activity, and hepatomas showed diamine oxidase activity of approximately 5- and 13-fold that of control liver, respectively. These results indicate an activation of terminal catabolism of polyamines in preneoplastic nodules and in hepatomas.
Sessa
A
A
Centro di Studio sulla Patologia Cellulare, Universita di Milano, Italy.
Desiderio
M A
MA
Perin
A
A
D015073:2-Acetylaminofluorene; D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D000818:Animals; D004052:Diethylnitrosamine; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology*; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced / Q000201:enzymology*; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D004052:Diethylnitrosamine; D015073:2-Acetylaminofluorene; D006631:Amine Oxidase (Copper-Containing); D005723:gamma-Glutamyltransferase