[Studies of 5-fluorouracil nanocapsules].
In this study, a new dosage form for antitumor agents--nanocapsules was prepared from biodegradable butylcyanoacrylate (BCA). Using 5-fluorouracil (5-Fu) as the model drug, scanning electron microscope pictures show that the maximum diameter of nanocapsules particles is about 338 nm. A new gel chromatography method is established for the determination of encapsulation efficiency in nanocapsules. The encapsulation efficiency of 5-Fu is 40.9%. LD50 of BCA is 267.7 mg/kg for intravenous injection in mice. The antitumor activities of 5-Fu nanocapsules on S180, HepS and EAC were found to be higher than that of free 5-Fu.
Pan
W S
WS
Shenyang College of Pharmacy.
Hu
J
J
D000818:Animals; D002214:Capsules; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004337:Drug Carriers; D004659:Enbucrilate / Q000633:toxicity; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy; D008297:Male; D051379:Mice; D011817:Rabbits; D012510:Sarcoma 180 / Q000188:drug therapy
D002214:Capsules; D004337:Drug Carriers; D004659:Enbucrilate; D005472:Fluorouracil