title: Human T cell receptor V alpha gene polymorphism.
abstract: The T cell receptor (TcR) is a heterodimer composed of an alpha,beta- or a gamma,delta-chain. The receptor is expressed on the cell surface in association with the CD3 complex, which in turn is composed of at least four chains (gamma, delta, epsilon, and zeta). In this review, we will summarize the recent findings on the genomic organization of the four T cell receptor genes, and the polymorphisms detected in the variable regions of these genes.
authors.affiliation: Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Chan
authors.forename: R P
authors.initials: RP
authors.lastname: Du
authors.forename: M
authors.initials: M
authors.lastname: Reis
authors.forename: L M
authors.initials: LM
authors.lastname: Meske
authors.forename: M
authors.initials: M
authors.lastname: Sheehy
authors.forename: E
authors.initials: E
authors.lastname: Baillie
authors.forename: T W
authors.initials: TW
authors.lastname: Mak
mesh_terms: D015342:DNA Probes; D005802:Genes, MHC Class II / Q000235:genetics*; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D016693:Receptors, Antigen, T-Cell, alpha-beta; D015183:Restriction Mapping
chemical_list: D015342:DNA Probes; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta