title: Calcium and phosphorus levels in serum and CSF in dementia.
abstract: Marked differences in CSF levels of both calcium and phosphorus were observed in patients with dementia and aged controls when compared with adult controls. A significant decrease in both Ca and P in CSF was observed in Alzheimer's type dementia (p less than 0.01) and multi-infarct dementia cases (p less than 0.01). The geriatric controls also showed a significant decrease in both Ca and P. A 60% decrease in diffusible Ca in CSF was noted both in patients and geriatric controls when compared to adult controls (p less than 0.001). Diffusible P was also decreased in all three groups (p less than 0.05). A marginal decrease in serum Ca and slight increase in P was observed in both patients and geriatric controls. The significant decrease in CSF Ca and P in both groups of patients compared with aged controls suggests this lowering of Ca and P is not due to solely to the aging process and indicates a role in the pathology of age-related disorders.
authors.affiliation: Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors.forename: M N
authors.initials: MN
authors.lastname: Subhash
authors.forename: T S
authors.initials: TS
authors.lastname: Padmashree
authors.forename: K N
authors.initials: KN
authors.lastname: Srinivas
authors.forename: D K
authors.initials: DK
authors.lastname: Subbakrishna
authors.forename: S K
authors.initials: SK
authors.lastname: Shankar
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000523:psychology; D002118:Calcium / Q000097:blood* / Q000134:cerebrospinal fluid*; D003704:Dementia / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000523:psychology; D015161:Dementia, Multi-Infarct / Q000097:blood / Q000134:cerebrospinal fluid / Q000523:psychology; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood* / Q000134:cerebrospinal fluid*; D011569:Psychiatric Status Rating Scales
chemical_list: D010758:Phosphorus; D002118:Calcium