Early postnatal hyperthyroidism improves both working and reference memory in a spatial radial-maze task in adult mice.
Newborn male pups of the inbred mouse strain DBA/2J were injected with a buffered solution of L-thyroxine, known to induce a hyperplasia of the intra- and infrapyramidal mossy fiber terminal fields (iip-MF). Because previous studies have shown that the size of the iip-MF correlates positively with both reference memory and working memory in a spatial radial maze task, we expected improved performance on such a task in the treated animals. Such an improvement was in fact found for both reference and working memory. We conclude that the iip-MF are functionally involved in the regulation of spatial learning and memory in mice.
Crusio
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WE
Génétique, Neurogénétique et Comportement, URA 1294 CNRS, UFR Biomédicale, Université Paris V René Descartes, France.
Schwegler
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D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001931:Brain Mapping; D004193:Discrimination Learning / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D051379:Mice; D008811:Mice, Inbred DBA; D009949:Orientation / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology*; D013963:Thyroid Hormones / Q000502:physiology*; D013974:Thyroxine / Q000502:physiology
D013963:Thyroid Hormones; D013974:Thyroxine