title: Oral cyclosporin A is effective in clearing persistent pustulosis palmaris et plantaris.
abstract: In a prospective open study, seven patients with persistent pustulosis palmaris et plantaris were treated with oral Cyclosporin A (CsA). Clinical efficacy was assessed on a semi-quantitative 0-4 point scale for erythema, desquamation, induration and pustulation. CsA controlled skin lesions in doses ranging from 1.1 to 6.1 mg/kg body weight/day. Clinical side effects included renal impairment, nausea and tiredness. Rapid recurrence of the skin lesions was observed on withdrawal or insufficient treatment with the drug.
authors.affiliation: Department of Dermatology, University of Amsterdam, The Netherlands.
authors.forename: M M
authors.initials: MM
authors.lastname: Meinardi
authors.forename: M A
authors.initials: MA
authors.lastname: de Rie
authors.forename: J D
authors.initials: JD
authors.lastname: Bos
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy*
chemical_list: D003524:Cyclosporins