title: Cardiovascular effects of Org OD 14--a new steroidal therapy for climacteric symptoms.
abstract: The cardiovascular effects of Org OD 14, a synthetic steroid which relieves climacteric symptoms without stimulating the endometrium, were assessed in a group of healthy post-menopausal women. Limb blood flow was measured by venous occlusion plethysmography. Resting forearm blood flow, the dilator response to anoxic exercise and heart rate increased significantly after six weeks of drug treatment. Hand flow was unchanged. The cardiovascular effects of Org OD 14 differ from those seen with oestrogens, in keeping with the unique pharmacological profile of this steroid.
authors.affiliation: Department of Endocrinology, Royal Free Hospital, London, U.K.
authors.forename: P
authors.initials: P
authors.lastname: Hardiman
authors.forename: P
authors.initials: P
authors.lastname: Nihoyannopoulos
authors.forename: P
authors.initials: P
authors.lastname: Kicovic
authors.forename: J
authors.initials: J
authors.lastname: Ginsburg
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002979:Climacteric / Q000187:drug effects* / Q000502:physiology; D005121:Extremities / Q000098:blood supply; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008606:Mental Processes / Q000187:drug effects; D008875:Middle Aged; D009652:Norpregnenes / Q000627:therapeutic use*; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D009652:Norpregnenes; C027385:tibolone