title: Sustained calcium channel blockade in the treatment of severe hypertension. A two year experience.
abstract: Thirty-nine patients with severe hypertension (diastolic blood pressure greater than 120 mm Hg) predominantly drawn from an inner-city population were placed on nifedipine gastrointestinal therapeutic system (GITS) for long-term treatment to achieve a sustained diastolic blood pressure less than 95 mm Hg. Fourteen patients failed to complete 6 months of therapy. For the 25 who remained in treatment for 6 months or more, systolic/diastolic blood pressure reductions were 62 +/- 5/40 +/- 2 mm Hg at 6 months; for those followed more than 12 months (n = 18), 58 +/- 7/37 +/- 3 mm Hg at 12 months; and for those followed more than 18 months (n = 11), 54 +/- 6/37 +/- 3 mm Hg at 18 months. Overall, 75% of these severely hypertensive patients were controlled with nifedipine GITS alone; 80% required 90 mg/day or more. During the two years of observation, no patient had a severe medical event, and 44% of those who entered remain in treatment. Left ventricular hypertrophy, as determined by echocardiography, diminished significantly during the course of treatment. These results indicate nifedipine GITS is well-tolerated and effective as monotherapy in the treatment of severe hypertension.
authors.affiliation: Department of Medicine, Mount Sinai Medical Center, New York City, NY 10029.
authors.forename: M
authors.initials: M
authors.lastname: Geizhals
authors.forename: R A
authors.initials: RA
authors.lastname: Phillips
authors.forename: M
authors.initials: M
authors.lastname: Ardeljan
authors.forename: L R
authors.initials: LR
authors.lastname: Krakoff
mesh_terms: D000328:Adult; D015220:Calcium Channels / Q000187:drug effects*; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D015220:Calcium Channels; D009543:Nifedipine