title: N-acetylation and debrisoquine hydroxylation polymorphisms in patients with Gilbert's syndrome.
abstract: 1. N-acetylation and debrisoquine hydroxylation phenotypes were determined in 54 patients with Gilbert's syndrome and in 247 (sulphamethazine) and 76 (debrisoquine) non-related healthy volunteers. 2. Forty (74.1%) of the patients and 135 (54.7%) of the healthy volunteers were slow acetylators (chi 2 = 6.87). In the patients, the cumulative urinary excretion of sulphamethazine up to 6 h (Ae(0,6)) was significantly lower. No differences in the frequency of debrisoquine poor metabolizers were observed: Gilbert's syndrome 5/54 (9.3%), healthy volunteers 5/76 (6.6%). The metabolic ratios were similar in both groups as well as the urinary recoveries of debrisoquine and its 4-hydroxy metabolite. 3. Gilbert's syndrome seems to be related in some way to N-acetylation but not to the debrisoquine hydroxylation polymorphism.
authors.affiliation: Department of Clinical Pharmacology, University of Greifswald, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Siegmund
authors.forename: J D
authors.initials: JD
authors.lastname: Fengler
authors.forename: G
authors.initials: G
authors.lastname: Franke
authors.forename: M
authors.initials: M
authors.lastname: Zschiesche
authors.forename: O
authors.initials: O
authors.lastname: Eike
authors.forename: E
authors.initials: E
authors.lastname: Eike
authors.forename: P
authors.initials: P
authors.lastname: Meisel
authors.forename: R
authors.initials: R
authors.lastname: Wulkow
mesh_terms: D000107:Acetylation; D000293:Adolescent; D000328:Adult; D000368:Aged; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D005878:Gilbert Disease / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D003647:Debrisoquin