title: Concurrent acute myeloid leukemia and systemic mastocytosis.
abstract: A 51-year-old woman presented with concurrent systemic mastocytosis and acute myeloid leukemia associated with a clonal karyotypic anomaly of t(8;21). Cytochemical, histologic, and cytogenetic studies helped in the distinction from a recently described entity: acute myeloid leukemia with marrow basophilia. Although the leukemia responded well to aggressive chemotherapy, the mastocytosis component worsened, illustrating the inherent resistance of mastocytosis to chemotherapy.
authors.affiliation: Institute of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
authors.forename: K F
authors.initials: KF
authors.lastname: Wong
authors.forename: J K
authors.initials: JK
authors.lastname: Chan
authors.forename: J C
authors.initials: JC
authors.lastname: Chan
authors.forename: Y L
authors.initials: YL
authors.lastname: Kwong
authors.forename: S K
authors.initials: SK
authors.lastname: Ma
authors.forename: T C
authors.initials: TC
authors.lastname: Chow
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001491:Basophils / Q000473:pathology; D003582:Cytogenetics; D003937:Diagnosis, Differential; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008415:Mastocytosis / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged