Myelopeptides effect on longevity and immunological parameters in mice with congenital immunodeficiency.
Myelopeptides (MP) are regulatory molecules produced by animal and human bone marrow cells. A highly purified MP fraction has been isolated from supernatant of the porcine bone marrow cell culture by gel chromatography on Sephadex G-25 and HPLC. MP correct defective antibody response to SRBC in MRL/lpr mice with spontaneous autoimmune disease and increase hemoglobin level in Wv/Wv mice with congenital anemia. Hemoglobin enhancement in Wv/Wv mice is connected with MP influence of differentiation and proliferation of hemopoietic stem cells. MP correction of immunological parameters in MRL/lpr mice resulted in 2-fold prolongation of their life span.
Mikhailova
A A
AA
Department of Immunology, Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Moscow.
Sorokin
S V
SV
Komponiec
N A
NA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000748:Anemia, Macrocytic / Q000151:congenital / Q000628:therapy*; D000818:Animals; D001327:Autoimmune Diseases / Q000151:congenital / Q000628:therapy*; D001853:Bone Marrow / Q000737:chemistry; D001854:Bone Marrow Cells; D006410:Hematopoiesis / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000151:congenital / Q000628:therapy*; D007155:Immunologic Factors / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008136:Longevity / Q000187:drug effects*; D008180:Lupus Erythematosus, Systemic / Q000628:therapy*; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology*; D009842:Oligopeptides; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D013552:Swine
D000276:Adjuvants, Immunologic; D007155:Immunologic Factors; D009842:Oligopeptides; D010455:Peptides; C048617:myelopeptides