title: Protection against chicken leucocytozoonosis provided by immunization with spleen homogenate infected with Leucocytozoon caulleryi.
abstract: Protection against chicken leucocytozoonosis was assessed in chickens immunized with spleen homogenates from chickens that had received sporozoites of Leucocytozoon caulleryi 7 or 13 days previously. Chickens immunized with the homogenate were challenged with sporozoites of L. caulleryi and observed for changes in clinical signs, parasitemia, serum-soluble antigen, and antibody responses. In chickens immunized with either the 7-day or 13-day homogenate, clinical signs and parasitemia were moderate, mild or absent. This was the case both after immunization with the homogenate and after sporozoite challenge. Immunization with spleen homogenates demonstrated protection against chicken leucocytozoonosis.
authors.affiliation: Poultry Disease Laboratory, National Institute of Animal Health, Gifu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Isobe
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Yoshihara
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis; D000953:Antigens, Protozoan / Q000097:blood; D002645:Chickens / Q000469:parasitology*; D004797:Enzyme-Linked Immunosorbent Assay; D016787:Haemosporida / Q000276:immunology*; D007114:Immunization / Q000662:veterinary; D011201:Poultry Diseases / Q000097:blood / Q000517:prevention & control*; D011528:Protozoan Infections / Q000097:blood / Q000517:prevention & control; D011529:Protozoan Infections, Animal; D013154:Spleen / Q000276:immunology / Q000469:parasitology*
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan