title: Antibodies to cerebellar soluble lectin CSL in multiple sclerosis.
abstract: Cerebrospinal fluid samples from 239 patients with various neurological disorders were tested for the presence of autoantibodies to an endogenous mannose-binding protein, the cerebellar soluble lectin CSL, by means of an immunoblotting test with rat CSL as antigen. 47 of 51 patients with multiple sclerosis were positive for anti-CSL compared with 30 of 188 patients with other neurological disorders. 14 of the 30 false-positive patients were over 60 years old, an age group not typical of multiple sclerosis patients. The specificity of the test for multiple sclerosis was 85% and the sensitivity 93.5%. The possibility that CSL is an important immunological target in multiple sclerosis allows new insights into the possible causes and development of this disorder.
authors.affiliation: Centre de Neurochimie du CNRS, Strasbourg, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Zanetta
authors.forename: J M
authors.initials: JM
authors.lastname: Warter
authors.forename: S
authors.initials: S
authors.lastname: Kuchler
authors.forename: P
authors.initials: P
authors.lastname: Marschal
authors.forename: L
authors.initials: L
authors.lastname: Rumbach
authors.forename: S
authors.initials: S
authors.lastname: Lehmann
authors.forename: C
authors.initials: C
authors.lastname: Tranchant
authors.forename: A
authors.initials: A
authors.lastname: Reeber
authors.forename: G
authors.initials: G
authors.lastname: Vincendon
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D005069:Evaluation Studies as Topic; D005189:False Positive Reactions; D006801:Humans; D015151:Immunoblotting / Q000379:methods; D037102:Lectins / Q000276:immunology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology*; D011237:Predictive Value of Tests
chemical_list: D001323:Autoantibodies; D037102:Lectins; C059525:cerebellar soluble lectin