title: Herpes simplex encephalitis with relapse.
abstract: Three children are described in whom herpes simplex encephalitis (HSE) followed a clearly biphasic course. The secondary deterioration may be due to a resurgence of the viral infection and calls into question the adequacy of current treatment regimens for HSE. Alternatively, a postinfectious neuroallergic process may be active in which case immunomodulatory treatment might be more appropriate than further antiviral treatment.
authors.affiliation: Hospital for Sick Children, London.
authors.forename: M G
authors.initials: MG
authors.lastname: Pike
authors.forename: C R
authors.initials: CR
authors.lastname: Kennedy
authors.forename: B G
authors.initials: BG
authors.lastname: Neville
authors.forename: M
authors.initials: M
authors.lastname: Levin
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D003907:Dexamethasone / Q000627:therapeutic use; D004660:Encephalitis / Q000382:microbiology*; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence
chemical_list: D003907:Dexamethasone; D000212:Acyclovir