[Hypophyseal tumors and diabetes mellitus. Hypothalamus-hypophyseal correlations and glucose metabolism].
As it's well known from the clinic, human syndromes depending on pituitary GH, ACTH and PRL secreting tumors are associated with alteration of glucose homeostasis. There is an hypothetical but convincing explanation for this, based on a number of concrete observations and experiments. The main mechanism for glucose intolerance or overt diabetes is related to insulin-resistance. The increased concentration of the three hormones would alter the action of insulin on its target cells at binding and (mainly) post-binding level. Besides recent researches indicate that the hypothalamus may play an important role in the pathogenesis of at least some cases of pituitary adenomas and, directly or indirectly, of the glucose homeostasis derangement.
Blasi
C
C
Istituto di II Clinica Medica, Università degli Studi di Roma La Sapienza.
Grossi
A
A
Tamburrano
G
G
D000236:Adenoma / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D003920:Diabetes Mellitus / Q000209:etiology / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism
D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone; D005947:Glucose
Tumori ipofisari e diabete mellito. Correlazioni ipotalamo-ipofisarie e ricambio glicidico.