Antiviral activity of an extract of Cordia salicifolia on herpes simplex virus type 1.
A partially purified extract (COL 1-6) from whole plant of Cordia salicifolia showed an inhibitory effect on herpes simplex virus type 1 (HSV-1). The activity of COL 1-6 on different steps of HSV-1 replication in HeLa cells was investigated. Under single-cycle replication conditions, COL 1-6 exerted a greater than 99.9% inhibition in virus yield when added to the cells 3 h or 1.5 h before infection, and even when added 8 h after infection the extract still caused a greater than 99% inhibition. The extract has been shown to have a direct virucidal activity. And also, analysis of early events following infection showed that COL 1-6 affected viral penetration in HeLa cells but did not interfere with adsorption to the cells.
Hayashi
K
K
Department of Virology, Toyama Medical and Pharmaceutical University, Toyama, Japan.
Hayashi
T
T
Morita
N
N
Niwayama
S
S
D000998:Antiviral Agents / Q000302:isolation & purification; D006367:HeLa Cells; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects*
D000998:Antiviral Agents; D010936:Plant Extracts