title: Cholinergic influence on memory facilitation induced by angiotensin II in rats.
abstract: The influence of the cholinesterase inhibitor galanthamine (Nivalin), of the cholinergic agonist oxotremorine, and of the muscarinic cholinergic antagonist scopolamine on the retention-improving effect of angiotensin II (AT II) was studied in male Wistar rats trained and tested for retention (24h later) using two paradigms: two-way active avoidance (shuttle-box) and passive (step-through) avoidance. AT II and the cholinergic agonists, administered together potentiated their retention-improving effects, while scopolamine abolished the memory effect of AT II. It is suggested that brain cholinergic neurotransmission participates in the mechanisms of the memory-facilitating effect of AT II.
authors.affiliation: Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
authors.forename: D I
authors.initials: DI
authors.lastname: Yonkov
authors.forename: V P
authors.initials: VP
authors.lastname: Georgiev
mesh_terms: D000109:Acetylcholine / Q000502:physiology*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D005702:Galantamine / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D010095:Oxotremorine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D005702:Galantamine; D000804:Angiotensin II; D010095:Oxotremorine; D012601:Scopolamine; D000109:Acetylcholine