[Study of an MPTP-induced parkinsonian animal model in the rhesus monkey and the mechanism of the action of MPTP].
In this paper are presented the data of the use of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to create a parkinsonian animal model in rhesus monkey. We studied the mechanism of the action of MPTP through testing monoamine oxidase B (MAO-B) inhibitor, deprenyl and L-prolyl-L-leucyl-glycinamide (PLG) against the neurotoxicity of MPTP. The results indicated that: (1) the use of MPTP can establish a useful parkinsonian animal model in rhesus monkey; (2) pretreatment with deprenyl can effectively prevent the neurotoxicity of MPTP; and (3) whether PLG can prevent or alleviate the neurotoxicity of MPTP requires further study.
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D000818:Animals; D004195:Disease Models, Animal; D020267:MPTP Poisoning; D009075:MSH Release-Inhibiting Hormone / Q000627:therapeutic use; D008253:Macaca mulatta; D008297:Male; D010302:Parkinson Disease, Secondary / Q000517:prevention & control; D012642:Selegiline / Q000627:therapeutic use
D012642:Selegiline; D009075:MSH Release-Inhibiting Hormone