title: Guanylate cyclase in human platelets with different aggregability.
abstract: The activity of human platelet guanylate cyclase, and the activation of the enzyme by sodium nitroprusside were decreased in platelets with increased aggregability; these platelets were obtained from diabetes mellitus patients. Anomalies in guanylate cyclase activity and ADP-induced aggregation were more pronounced in platelets from subjects with type II than those with type I diabetes.
authors.affiliation: Institute of Biological and Medical Chemistry, USSR Academy of Medical Sciences, Moscow.
authors.lastname: Chirkov YuYu
authors.forename: I A
authors.initials: IA
authors.lastname: Tyshchuk
authors.forename: I S
authors.initials: IS
authors.lastname: Severina
mesh_terms: D000244:Adenosine Diphosphate; D001792:Blood Platelets / Q000201:enzymology*; D003920:Diabetes Mellitus / Q000097:blood / Q000201:enzymology; D005260:Female; D006162:Guanylate Cyclase / Q000097:blood*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation
chemical_list: D000244:Adenosine Diphosphate; D006162:Guanylate Cyclase