title: Family data determine all parameters in Mendelian incomplete penetrance models.
abstract: We show that data on the frequency of occurrence of an hereditary trait in family members can be used to determine all four parameters in a Mendelian genetic model with incomplete penetrance. Thus previous statements in the literature that such data can determine only three combinations of the parameters are incorrect.
authors.affiliation: Department of Health Research and Policy, Stanford University School of Medicine, CA 94305-5092.
authors.forename: A S
authors.initials: AS
authors.lastname: Whittemore
authors.forename: J B
authors.initials: JB
authors.lastname: Keller
authors.forename: M J
authors.initials: MJ
authors.lastname: Ward
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D009679:Nuclear Family; D010641:Phenotype; D011336:Probability