K20 and ICO-10 monoclonal antibodies (gp120/200; Thy-1): immunophenotyping of human solid tumours.
Solid tumour cells were shown to express VLA-beta and Thy-1 antigens. For identification of these molecules two monoclonal antibodies, K-20 and ICO-10, characterised in detail previously, were used. Four groups of solid tumours have been identified according to their immunophenotype: VLA-beta+ and Thy-1-; VLA-beta+ and Thy-1+; VLA-beta- and Thy-1+; VLA-beta- and Thy-1-. To a certain extent these groups have been shown to reflect tumour histogenesis: tumours of epithelial origin never expressed an ICO-10+, K20-phenotype while soft tissue sarcomas and neuroblastoma cells never expressed the beta-chain of VLA molecular complexes.
Kadagidze
Z G
ZG
Laboratory of Clinical Radioimmunology, All-Union Cancer Research Centre of the AMS USSR, Moscow.
Tupitsyn
N N
NN
Baryshnikov
A J
AJ
Kadyrov
K P
KP
Blinov
V M
VM
Bernard
A
A
Amiot
M
M
Boumsell
L
L
D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000276:immunology*; D010641:Phenotype; D016029:Receptors, Very Late Antigen / Q000276:immunology; D018800:Thy-1 Antigens
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000954:Antigens, Surface; D016029:Receptors, Very Late Antigen; D018800:Thy-1 Antigens