title: Familial incidence of C3 nephritic factor.
abstract: C3 nephritic factor (NEF) has been found in 3 siblings presenting different (or none) degrees of renal disease. Other relatives, including their dead father, suffered from a renal illness. In 2 of the siblings, NEF activity was restricted to IgG1 and IgG3 subclasses. Familial NEF incidence and a shared C3 allotype and a common HLA haplotype including BfS alleles for the 3 NEF-positive siblings suggest that at least in our cases genetical factors may be involved in NEF generation.
authors.affiliation: Immunology Unit, Hospital La Paz, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: López-Trascasa
authors.forename: J M
authors.initials: JM
authors.lastname: Martín-Villa
authors.forename: J L
authors.initials: JL
authors.lastname: Vicario
authors.forename: M A
authors.initials: MA
authors.lastname: Marín
authors.forename: J
authors.initials: J
authors.lastname: Martínez-Ara
authors.forename: M C
authors.initials: MC
authors.lastname: García-Messeguer
authors.forename: A
authors.initials: A
authors.lastname: Arnáiz-Villena
authors.forename: G
authors.initials: G
authors.lastname: Fontán
mesh_terms: D000293:Adolescent; D000328:Adult; D003176:Complement C3 / Q000032:analysis / Q000235:genetics; D003178:Complement C3 Nephritic Factor / Q000032:analysis / Q000235:genetics*; D003181:Complement C4 / Q000032:analysis; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000145:classification; D008297:Male; D008875:Middle Aged; D010641:Phenotype
chemical_list: D003176:Complement C3; D003178:Complement C3 Nephritic Factor; D003181:Complement C4; D006680:HLA Antigens; D007074:Immunoglobulin G