HLA-DR, DQ and T cell antigen receptor constant beta genes in Japanese patients with ulcerative colitis.
We studied the T cell antigen receptor (TcR) constant beta chain genes on HLA typed Japanese patients with ulcerative colitis (UC). A TcR constant beta EcoRI 6.0-kb fragment was present in all Japanese UC patients (n = 17) but completely absent in the controls (n = 35) (chi2 = 47.6, P less than 0.001). The frequency of HLA-DR2 antigen was significantly higher in UC patients (85% versus 28% in controls, P less than 0.001). Furthermore, HLA-DQw1 antigen was also increased in UC patients (96% versus 60% in controls, P less than 0.001). However, HLA-DR4 antigen was significantly decreased in UC patients (12% versus 37%, P = 0.02). HLA-DR1 antigen was not found in UC patients and was present in only 15% of the controls. These results suggest that TcR beta chain and HLA-DQw1 antigen may be important in the pathogenesis of Japanese UC.
Kobayashi
K
K
Department of Laboratory Medicine, National Defense Medical College, Saitama, Japan.
Atoh
M
M
Konoeda
Y
Y
Yagita
A
A
Inoko
H
H
Sekiguchi
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003093:Colitis, Ulcerative / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D005260:Female; D005796:Genes / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D011948:Receptors, Antigen, T-Cell