[An experimental study on effect of bone morphogenetic protein and fibrin sealant in tendon implantation into bone].
The purpose of this investigation was to raise the strength of bone-tendon junctions. Fibrin sealant system and bone morphogenetic protein (BMP) was utilized for tendon implantations in bones. Histological findings, findings of soft X-ray radiograms and changes of the tensile strength at bone-tendon junctions were investigated with the passage of time after a free tendon was inserted into a bone tunnel in the lateral femoral condyle of rabbits and fixed with a pull-out suture. There were 4 groups, (BMP(-).Fibrin(-) Group, BMP(+).Fibrin(-) Group, BMP(-).Fibrin(+) Group, and BMP(+).Fibrin(+) Group). In the BMP(+).Fibrin(+) Group the tendon was combined with the bone at 3 weeks the earliest of the 4 groups. These findings would indicate that the fibrin sealant introduced many fibroblastic cells and undifferential mesenchymal cells early and accelerated restoration of tissue around the tendon. Moreover, BMP incorporated with the fibrin sealant probably acted on the objective region without obstructing the BMP. The fibrin sealant, and the mixture of BMP and fibrin sealant enabled early tendon union with the bone, but didn't contribute to the early formation of enthesis.
Itoh
O
O
Department of Orthopaedic Surgery, Nagoya University School of Medicine, Aichi, Japan.
D000818:Animals; D019485:Bone Morphogenetic Proteins; D005269:Femur / Q000502:physiology / Q000601:surgery; D015718:Fibrin Tissue Adhesive; D011506:Proteins; D011817:Rabbits; D013710:Tendons / Q000502:physiology / Q000637:transplantation*; D013977:Tibia / Q000502:physiology / Q000601:surgery; D014945:Wound Healing
D019485:Bone Morphogenetic Proteins; D015718:Fibrin Tissue Adhesive; D011506:Proteins