Efferent connections of the striatopallidal and amygdaloid components of the substantia innominata in the cat: projections to the nucleus accumbens and caudate nucleus.
Enkephalin immunoreactivity is used to divide the feline substantia innominata into circumscript subregions, i.e. the "striatopallidal system" and the "extended amygdala". In addition, enkephalin immunoreactivity is used to subdivide the striatopallidal system into two distinct areas, i.e. the subcommissural part of the globus pallidus displaying high enkephalin immunoreactivity and the ventral pallidum displaying moderate enkephalin immunoreactivity. The anterograde axonal transport of Phaseolus vulgaris-leucoagglutinin is used to study the efferents of these areas innervating the caudate nucleus and the nucleus accumbens. It is found that the enkephalin-immunoreactive subcommissural part of the globus pallidus as well as the dorsal enkephalin-immunoreactive regions of the extended amygdala project topographically along a rostrocaudal and mediolateral dimension to the nucleus accumbens. The far rostral parts of the caudate nucleus are found to be innervated by the subcommissural part of the globus pallidus whereas the extended amygdala has no such connection. This pathway is also found to be topographically organized along a mediolateral dimension. The non-enkephalin-immunoreactive area ventral and lateral to the subcommissural part of the globus pallidus is found to have no projections to the nucleus accumbens and caudate nucleus. This region rather innervates the olfactory tubercle. In contrast to the striatopallidal system the sublenticular part of the extended amygdala preferentially projects to the adjoining part of the extended amygdala, i.e. the bed nucleus of the stria terminalis. However, the ventral regions preferentially innervate the medial division of the bed nucleus of the stria terminalis whereas the dorsal regions preferentially innervate the lateral division of the bed nucleus of the stria terminalis. These data indicate that the differential forebrain systems represented in the feline substantia innominata, i.e. the striatopallidal system and extended amygdala have differential output stations. The results are discussed in view of the role of the subcommissural part of the globus pallidus and the nucleus accumbens in orofacial dyskinesia and schizophrenia, respectively.
Spooren
W P
WP
Department of Pharmacology, University of Nijmegen, The Netherlands.
Veening
J G
JG
Groenewegen
H J
HJ
Cools
A R
AR
D000679:Amygdala / Q000502:physiology; D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology; D004525:Efferent Pathways / Q000502:physiology; D004745:Enkephalins / Q000378:metabolism; D005917:Globus Pallidus / Q000502:physiology; D007150:Immunohistochemistry; D007267:Injections; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D009714:Nucleus Accumbens / Q000502:physiology*; D010835:Phytohemagglutinins; D013377:Substantia Innominata / Q000502:physiology*
D004745:Enkephalins; D010835:Phytohemagglutinins; C100156:leukoagglutinins, plants