Tetracycline does not affect the trauma- and leukotriene B4-induced intraepidermal accumulation of polymorphonuclear leukocytes.
The transepidermal migration of polymorphonuclear leukocytes is a well established target for antipsoriatic therapies. Tetracycline, although inhibiting the movement of PMN, is not an effective treatment for psoriasis. In contrast to the inhibition of PMN chemotactic response to serum and bacterial products, the leukotriene B4-induced and trauma-induced intraepidermal accumulation of PMN was unaffected by tetracycline.
Chang
A
A
Department of Dermatology, University Hospital, Nijmegen, The Netherlands.
Steegmans
P
P
van de Kerkhof
P C
PC
D000328:Adult; D001706:Biopsy; D002449:Cell Aggregation / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D004817:Epidermis / Q000187:drug effects*; D005260:Female; D006801:Humans; D007975:Leukotriene B4 / Q000502:physiology*; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D011565:Psoriasis / Q000188:drug therapy; D013754:Tetracyclines / Q000008:administration & dosage / Q000494:pharmacology*
D013754:Tetracyclines; D007975:Leukotriene B4