title: Probe, VK5B, is located in the same interval as the autosomal dominant adult polycystic kidney disease locus, PKD1.
abstract: The polymorphic DNA probe VK5B (D16S94) was mapped by genetic linkage in families from the Centre d'Etude de Polymorphisme Humain (CEPH) as being in the same interval as the autosomal dominant adult polycystic kidney disease locus (PKD1). The maximum likelihood estimate of the genetic location of VK5B using multipoint linkage analysis was 9.6 cM proximal to 3'HVR (D16S85) and 5.4 cM distal to CRI-0327 (D16S63), in males. The VK5B probe may be useful in PKD1 families for prenatal and presymptomatic diagnosis of the disease. Additional typing of PKD1 families is required to determine whether the location of VK5B is distal or proximal to (PKD1).
authors.affiliation: Cytogenetics Unit, Adelaide Children's Hospital, South Australia.
authors.forename: V J
authors.initials: VJ
authors.lastname: Hyland
authors.forename: G K
authors.initials: GK
authors.lastname: Suthers
authors.forename: K
authors.initials: K
authors.lastname: Friend
authors.forename: R N
authors.initials: RN
authors.lastname: MacKinnon
authors.forename: D F
authors.initials: DF
authors.lastname: Callen
authors.forename: M H
authors.initials: MH
authors.lastname: Breuning
authors.forename: T
authors.initials: T
authors.lastname: Keith
authors.forename: V A
authors.initials: VA
authors.lastname: Brown
authors.forename: P
authors.initials: P
authors.lastname: Phipps
authors.forename: G R
authors.initials: GR
authors.lastname: Sutherland
mesh_terms: D000328:Adult; D002885:Chromosomes, Human, Pair 16; D015342:DNA Probes; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree; D007690:Polycystic Kidney Diseases / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
chemical_list: D015342:DNA Probes