[The effect of hydrocortisone on posttetanic potentiation in rat cerebral cortex slices and the molecular mechanisms of this effect].
The effect of hydrocortisone on posttetanic potentiation, Ca exchange, metabolism of phosphoinositides and phospholipids methylation, was studied. Hydrocortisone (10(-4) M) facilitated and prolonged the posttetanic potentiation. Incubation of slices in hydrocortisone for 90 sec elevated the incorporation of 32P-orthophosphate in polyphosphoinositide. Within 2 min of hydrocortisone action, the rate constant of Ca entry increased two-fold, transmembrane exchange fluxes of Ca increasing, too. Incorporation of 14C-methyl group in different phospholipids was considerably increased after 20-min hydrocortisone action.
Emel'ianov
N A
NA
Bagaeva
T R
TR
Gerasimova
I A
IA
Mokrushin
A A
AA
Pavlinova
L I
LI
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002132:Calcium Radioisotopes; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008745:Methylation; D010716:Phosphatidylinositols / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002132:Calcium Radioisotopes; D010716:Phosphatidylinositols; D010743:Phospholipids; D002118:Calcium; D006854:Hydrocortisone
Vliianie gidrokortizona na posttetanicheskuiu potentsiatsiiu v srezakh kory mozga krys i nekotorye molekuliarnye mekhanizmy étogo éffekta.