title: Chronic benzodiazepine dependence. A comparative study of abrupt withdrawal under propranolol cover versus gradual withdrawal.
abstract: Thirty-one patients dependent on benzodiazepines were randomly assigned to either slow withdrawal (SW) or abrupt withdrawal under propranolol cover (PW). Of 16 patients in the SW group, 11 successfully withdrew from their drugs, while only 4 out of 15 in the PW group did so. Patients in the SW group had only mild withdrawal symptoms, while those in the PW group suffered more severe symptoms, which lasted around four weeks. In all, 81% of the whole group suffered withdrawal symptoms of some kind. Patients in both groups were significantly less anxious at the end of the study than at baseline. Younger subjects and those who were more severely anxious at the start of the trial had more difficulty in withdrawing than older and less anxious patients.
authors.affiliation: Abraham Cowley Unit, St Peter's Hospital, Chertsey, Surrey.
authors.forename: T
authors.initials: T
authors.lastname: Cantopher
authors.forename: S
authors.initials: S
authors.lastname: Olivieri
authors.forename: N
authors.initials: N
authors.lastname: Cleave
authors.forename: J G
authors.initials: JG
authors.lastname: Edwards
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001569:Benzodiazepines; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D011379:Prognosis; D011433:Propranolol / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D011433:Propranolol