[Cancer metastasis and recurrence from the standpoint of amplification and expression of oncogenes in human malignant tumors].
We investigated the amplification and expression of oncogenes in human malignant tumors. The survival rates of patients with c-erbB, c-erbB-2, and int-2 oncogene amplification/expression were significantly lower than those of the patients without gene amplification/expression. Many distant organ metastases were observed in esophageal cancer patients with int-2 amplification, in gastric cancer patients with c-erbB-2 over-expression, and in breast cancer patients with int-2 and c-erbB-2 amplification. These results suggest that the amplification/expression of these oncogenes may serve as good markers for determining the biological malignancy of cancers.
Kikuchi
K
K
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
Ueda
M
M
Kitagawa
Y
Y
Ando
N
N
Abe
O
O
D005784:Gene Amplification; D015870:Gene Expression; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000401:mortality*; D009857:Oncogenes; D012008:Recurrence