[The characteristics of the interaction of the thyroliberin analog RGH 2202 and narcotic analgesics].
The effect of an thyroliberin analogue RGH 2202 on respiration inhibition induced by narcotic analgetics and on their antinociceptive action was studied in experiments on mice, rabbits and rats. RGH 2202 (10 mg/kg, intravenously) was found to exert no effect on the antinociceptive effect of morphine in mice and rabbits. Meanwhile, RGH 2202 in doses of 1 to 5 mg/kg intravenously abolished the respiration inhibition induced by fentanyl (0.02-0.07 mg/kg, intravenously) or morphine (10 mg/kg, intravenously) in rabbits and rats. After administration of RGH 2202 in doses of 10-40 mg/kg intravenously no significant changes of arterial blood pressure or heart rate were observed. The results obtained suggest that RGH 2202 may be used for relieving the inhibitory effects of narcotic analgetics on the respiratory centre during intoxication with these agents and in anesthesiological practice.
Chichenkov
O N
ON
Shorr
V A
VA
Voĭnov
V A
VA
Abramov
Iu B
IuB
Chizh
B A
BA
Bulaev
V M
VM
D000701:Analgesics, Opioid / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004576:Electromyography; D005260:Female; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D011817:Rabbits; D012119:Respiration / Q000187:drug effects / Q000502:physiology; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors
D000701:Analgesics, Opioid; D013973:Thyrotropin-Releasing Hormone; C055448:posatirelin
Osobennosti vzaimodeĭstviia analoga tiroliberina RGH 2202 i narkoticheskikh anal'getikov.