[The protective properties of a porin from the outer membrane of Yersinia pseudotuberculosis].
The protective properties of the species-specific pore-forming polypeptide of Y. pseudotuberculosis outer membrane (porin) were studied. The study showed that 80-90% of mice immunized with porin survived after challenge with 10-30 LD50 of Y. pseudotuberculosis, serovars 1 and 3. The LD50 of the preparation exceeded its ED50 more than 100-fold. Immunization made in two injections was more effective than immunization in one injection. The immunization of the animals with porin led to an increase in the activity of peritoneal exudate macrophages with respect to Y. pseudotuberculosis, serovars 1 and 3.
Timchenko
N F
NF
Novikova
O D
OD
Pavlova
T N
TN
Venediktov
V S
VS
Solov'eva
T F
TF
D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D007114:Immunization / Q000379:methods; D007928:Lethal Dose 50; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D018272:Porins; D013045:Species Specificity; D015011:Yersinia pseudotuberculosis / Q000276:immunology*; D015012:Yersinia pseudotuberculosis Infections / Q000517:prevention & control
D001425:Bacterial Outer Membrane Proteins; D018272:Porins
Protektivnye svoĭstva porina iz vneshneĭ membrany Yersinia pseudotuberculosis.