[Vitamin D supplementation in institutionalized elderly. Effects of vitamin D3 (100,000 IU) orally administered every 3 months on serum levels of 25-hydroxyvitamin D].
A clinical trial carried out during the autumn/winter season in 46 institutionalized elderly subjects (35 women, 11 men) (group mean age = 83 +/- 2 years) revealed a severe deficiency in vitamin D in these subjects (25-hydroxyvitamin D level less than or equal to 3 ng/ml). After oral administration of 100,000 IU of vitamin D3, an increase in 25-hydroxyvitamin D levels above the 10 ng/ml threshold was observed and maintained for three months. A second dose, administered after 3 months, made it possible to sustain this level. No sign of toxicity was detected, notably no trace of hypercalcemia. In contrast, no change in the deficit (25-hydroxyvitamin D level less than or equal to 3 ng/ml) was seen in the placebo population. Three-monthly administration of the moderate dosage of 100,000 IU of vitamin D3 all year round would offer a simple, effective and risk-free system to counteract vitamin D deficiency in the elderly and of preventing the risk of osteomalacia, thus reducing the incidence of fractures.
Zeghoud
F
F
C.N.R.S. URA 583, Université Paris V, Hôpital Necker, Paris.
Jardel
A
A
Garabedian
M
M
Salvatore
R
R
Moulias
R
R
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D005598:Fractures, Spontaneous / Q000517:prevention & control; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood*; D008297:Male; D010018:Osteomalacia / Q000517:prevention & control; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy*
D006887:Hydroxycholecalciferols; D002762:Cholecalciferol
Supplémentation vitaminique D chez des sujets âgés placés en institution. Effets sur les concentrations sériques en 25-hydroxyvitamine D d'une administration orale trimestrielle de vitamine D3 (100,000 UI).