title: Interaction between systemic circulation and brain injuries in newborns.
abstract: In several studies different pathogenetic mechanisms of metabolic and/or cardiovascular origin were shown depending on the type of hypoxic or hypoxic/hypercapnic stress and conditions of animals (normal developed or intrauterine growth retarded newborn piglets). Thus, in normal-weight piglets the prevention of compensatory hyperventilation owing to severe hypoxia (artificially ventilated animals) leads to critical, i.e. lethal acidosis. In intrauterine growth retarded piglets, a severe hypoxia cannot be vitally compensated because of the restricted circulatory centralization. Moreover, a limited cerebrovascular dilatation during moderate hypoxia/hypercapnia produces a critical state of the metabolic supply in those animals.
authors.affiliation: Friedrich Schiller University Jena, Institute of Pathological Physiology, F.R.G.
authors.forename: R
authors.initials: R
authors.lastname: Bauer
authors.forename: U
authors.initials: U
authors.lastname: Zwiener
authors.forename: W
authors.initials: W
authors.lastname: Buchenau
authors.forename: R
authors.initials: R
authors.lastname: Bergmann
authors.forename: R
authors.initials: R
authors.lastname: Beyer
authors.forename: G J
authors.initials: GJ
authors.lastname: Beyer
authors.forename: D
authors.initials: D
authors.lastname: Hoyer
authors.forename: V
authors.initials: V
authors.lastname: Lampe
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001775:Blood Circulation; D001930:Brain Injuries / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology; D002319:Cardiovascular System / Q000503:physiopathology; D005314:Embryonic and Fetal Development; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D007231:Infant, Newborn; D012119:Respiration