Comparative efficacy of combination fansidar-sulphate quinine and fansidar-chloroquine in mixed malaria infections of P. falciparum-P. vivax in children.
From January 1987 until March 1990, 61 children suffering from mixed malaria infections of P. falciparum and P. vivax entered the Department of Child Health Medical School Sam Ratulangi University/Gunung Wenang General Hospital, Manado. Only 41 patients were evaluated as 20 patients did not fulfill the inclusion criteria. Twenty patients were treated with fansidar-quinine (Group I), and 21 patients with fansidar chloroquine (Group II). In group II, the asexual form of P. vivax disappeared in 2 days after having been treated with fansidar-chloroquine. Conversely, in group I the asexual form of P. vivax disappeared after 5 days of treatment. Statistical analysis showed a significant difference (p less than 0.001). No significant difference could be detected between the duration of asexual parasitemia of P. falciparum in these two groups (p = 0.3085). No statistically significant difference could be detected concerning the duration of fever and the length of hospitalization between these two groups.
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Department of Child Health Medical School, Sam Ratulangi University, Gunung Wenang Hospital, Manado, Indonesia.
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D000293:Adolescent; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use*; D004338:Drug Combinations; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007902:Length of Stay; D016778:Malaria, Falciparum / Q000188:drug therapy*; D016780:Malaria, Vivax / Q000188:drug therapy*; D008297:Male; D011446:Prospective Studies; D011739:Pyrimethamine / Q000627:therapeutic use*; D011803:Quinine / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000627:therapeutic use*
D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D002738:Chloroquine; D011803:Quinine; D011739:Pyrimethamine