Putative gamma-subunit of the IL-2 receptor is detected in low, intermediate, and high affinity IL-2 receptor-bearing cells.
Three forms of the IL-2R have been reported: low, intermediate, and high affinity. Each form correlates with the expression of two different chains: p55 (alpha-subunit) and p75 (beta-subunit). We report here a putative new subunit of the IL-2R, termed p95-110 or gamma-subunit. This new subunit has a molecular mass of 95 to 110 kDa and is expressed in low, intermediate, and high affinity IL-2R-bearing cells. We propose that p95-110 is the partner of p75 in the formation of intermediate affinity IL-2R, inasmuch as neither p75 nor p95-110 alone can bind IL-2.
Colamonici
O R
OR
Tumor Cell Biology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Neckers
L M
LM
Rosolen
A
A
D015815:Cell Adhesion Molecules / Q000378:metabolism; D002460:Cell Line; D003432:Cross-Linking Reagents; D006801:Humans; D066298:In Vitro Techniques; D018799:Intercellular Adhesion Molecule-1; D007376:Interleukin-2 / Q000378:metabolism*; D046911:Macromolecular Substances; D008970:Molecular Weight; D011233:Precipitin Tests; D015375:Receptors, Interleukin-2 / Q000378:metabolism / Q000648:ultrastructure*
D015815:Cell Adhesion Molecules; D003432:Cross-Linking Reagents; D007376:Interleukin-2; D046911:Macromolecular Substances; D015375:Receptors, Interleukin-2; D018799:Intercellular Adhesion Molecule-1