Tubulointerstitial nephritis induced by Tamm-Horsfall protein sensitization in guinea pigs.
Experimental tubulointerstitial nephritis (TIN) was induced in guinea pigs by immunization with homologous Tamm-Horsfall protein (THP). This disease was characterized by focal interstitial mononuclear cell infiltration around the distal nephron segments with degeneration of renal tubular cells. Although concomitant granular immunoglobulin deposition on the tubular basement membrane and a rise of serum anti-THP antibodies were recognized, they were related to the severity of the lesion. Lymphocytes from lymph nodes of animals with TIN showed blast transformation in the presence of THP in vitro. Following the transfer of lymphocytes and spleen cells from guinea pigs with THP-induced TIN to nonimmunized animals, the recipient animals developed TIN 7 days later. These observations suggest that TIN induced in guinea pigs by challenge with homologous THP may, at least in part, be related to a cell-mediated immune response.
Sato
K
K
Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Oguchi
H
H
Yoshie
T
T
Koiwai
T
T
D000818:Animals; D000917:Antibody Formation / Q000502:physiology; D005260:Female; D006168:Guinea Pigs; D007111:Immunity, Cellular; D007116:Immunization, Passive; D007668:Kidney / Q000473:pathology; D008213:Lymphocyte Activation / Q000276:immunology; D009088:Mucoproteins / Q000276:immunology* / Q000302:isolation & purification; D009395:Nephritis, Interstitial / Q000276:immunology* / Q000473:pathology; D058949:Uromodulin
D009088:Mucoproteins; D058949:Uromodulin