title: [Cancer metastasis and recurrence from the standpoint of amplification and expression of oncogenes in human malignant tumors].
abstract: We investigated the amplification and expression of oncogenes in human malignant tumors. The survival rates of patients with c-erbB, c-erbB-2, and int-2 oncogene amplification/expression were significantly lower than those of the patients without gene amplification/expression. Many distant organ metastases were observed in esophageal cancer patients with int-2 amplification, in gastric cancer patients with c-erbB-2 over-expression, and in breast cancer patients with int-2 and c-erbB-2 amplification. These results suggest that the amplification/expression of these oncogenes may serve as good markers for determining the biological malignancy of cancers.
authors.affiliation: Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: Y
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: N
authors.initials: N
authors.lastname: Ando
authors.forename: O
authors.initials: O
authors.lastname: Abe
mesh_terms: D005784:Gene Amplification; D015870:Gene Expression; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000401:mortality*; D009857:Oncogenes; D012008:Recurrence