title: Adenosine inhibits a GABAB receptor-mediated hyperpolarizing postsynaptic potential in neurons of rat septal nuclei.
abstract: Intracellular recordings were made from neurons of rat dorsolateral septal nucleus (DLSN), in vitro. Adenosine and 2-chloroadenosine (1-500 microM) hyperpolarized DLSN neurons and blocked the excitatory postsynaptic potential (EPSP) and the late hyperpolarizing potential (LHP) in the presence of bicuculline. Adenosine did not depress the glutamate-induced potential. Bath-application of adenosine depressed the baclofen-induced potential in 60% of the neurons. Adenosine also inhibited the LHP in the remaining 40% of neurons, while it did not depress the baclofen-induced potential in these neurons. These results indicate that adenosine inhibits the EPSP pre-synaptically whereas it inhibits the LHP both pre- and postsynaptically in rat septal nuclei.
authors.affiliation: Department of Physiology, Kurume University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hasuo
authors.forename: S
authors.initials: S
authors.lastname: Shoji
authors.forename: T
authors.initials: T
authors.lastname: Akasu
authors.forename: J P
authors.initials: JP
authors.lastname: Gallagher
mesh_terms: D000241:Adenosine / Q000502:physiology*; D000818:Animals; D005071:Evoked Potentials / Q000502:physiology; D066298:In Vitro Techniques; D009474:Neurons / Q000502:physiology*; D051381:Rats; D011963:Receptors, GABA-A / Q000502:physiology*; D012686:Septal Nuclei / Q000502:physiology*
chemical_list: D011963:Receptors, GABA-A; D000241:Adenosine