Disturbed hypothalamic-pituitary axis in idiopathic recurring hypersomnia syndrome.
Disturbed function of the hypothalamic-pituitary axis at adrenal and thyroid levels was found during an episode of hypersomnia in the idiopathic recurring hypersomnia syndrome. These endocrinological abnormalities, abolished ACTH and cortisol responses to insulin-induced hypoglycemia and absent TSH response to TRH, normalised thereafter in the symptom-free interval. These data support the hypothesis that Kleine-Levin syndrome is related to an intermittent hypothalamic dysfunction.
Fernández
J M
JM
Department of Neurology, Hospital Ramón y Cajal, Madrid, Spain.
Lara
I
I
Gila
L
L
O'Neill of Tyrone
A
A
Tovar
J
J
Gimeno
A
A
D000293:Adolescent; D000324:Adrenocorticotropic Hormone; D001786:Blood Glucose / Q000378:metabolism; D006970:Disorders of Excessive Somnolence / Q000097:blood*; D004660:Encephalitis / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007328:Insulin; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D019965:Neurocognitive Disorders / Q000097:blood; D012008:Recurrence; D013577:Syndrome; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
D001786:Blood Glucose; D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D006854:Hydrocortisone