The pharmacokinetics of oxycodone after intravenous injection in adults.
Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative day. Plasma was sampled for up to 12 h. Mean values of t1/2z, CL and Vss were 222 min, 0.78 l min-1 and 2.60 l kg-1, respectively. The concentrations of the metabolite noroxycodone was also measured. The mean AUC(0,12) ratio of noroxycodone to oxycodone was 0.33. Oxymorphone was not detected.
Pöyhiä
R
R
Department of Anaesthesia, University of Helsinki, Finland.
Olkkola
K T
KT
Seppälä
T
T
Kalso
E
E
D000328:Adult; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010098:Oxycodone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010111:Oxymorphone / Q000493:pharmacokinetics
D010111:Oxymorphone; D010098:Oxycodone