[The hyperimmunoglobulin E syndrome].
Hyperimmunoglobulin E syndrome is a rare disease. The clinical and immunological features of HIE are discussed on the basis of a case history. A 28 year old woman had a life-long history of infections of the skin and the sinopulmonary tract. Because of elevated serum-IgE and several positive skin- and RAST-tests she had erroneously been classified as having multiple allergies including food allergy. We found a very high serum-IgE and negative challenge test. Additionally we found decreased oxidative metabolism of blood neutrophils and monocytes. This finding could explain the increased susceptibility to infections in HIE-patients.
Larsen
B B
BB
Lungemedicinsk afdeling, Arhus Kommunehospital.
Pedersen
B
B
Dahl
R
R
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007589:Job Syndrome / Q000097:blood / Q000175:diagnosis* / Q000276:immunology
Hyperimmunglobulin E syndromet.