Mouse dominant lethal and bone marrow micronucleus studies on methyl vinyl sulfone and divinyl sulfone.
Methyl vinyl sulfone and divinyl sulfone were tested for the induction of dominant lethal mutations and micronucleated bone-marrow erythrocytes in male mice. These chemicals were chosen for study because of their similarities in structure and chemical reactivity to acrylamide which is known to induce both effects. Following administration of the test compounds by intraperitoneal injection at the maximum tolerated doses, no evidence of induced dominant lethal mutations or micronucleated bone-marrow cells was observed for either chemical. It is concluded that structures and Michael reactivities similar to acrylamide are not sufficient to impart similar in vivo genetic toxicity to MVS and DVS.
Shelby
M D
MD
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Gutierrez-Espeleta
G A
GA
Generoso
W M
WM
McFee
A F
AF
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D003433:Crosses, Genetic; D005260:Female; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D011247:Pregnancy; D013450:Sulfones / Q000633:toxicity*
D009153:Mutagens; D013450:Sulfones; C060916:methyl vinyl sulfone; C009873:divinyl sulfone