title: Membrane-bound phospholipase C activity in normal and psoriatic epidermis.
abstract: We report the quantification of a membrane-bound phospholipase C in human epidermis which is active against the physiologically relevant substrate, phosphatidylinositol 4,5-bisphosphate. The level of this enzyme is significantly increased in the psoriatic lesion, both on a weight and protein basis. Etiological implications of this observation are discussed.
authors.affiliation: Department of Dermatology, University Hospital, Nijmegen, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Bergers
authors.forename: P C
authors.initials: PC
authors.lastname: van de Kerkhof
authors.forename: R
authors.initials: R
authors.lastname: Happle
authors.forename: P D
authors.initials: PD
authors.lastname: Mier
mesh_terms: D001706:Biopsy; D004817:Epidermis / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000037:antagonists & inhibitors; D011565:Psoriasis / Q000201:enzymology*; D010738:Type C Phospholipases / Q000032:analysis / Q000378:metabolism*
chemical_list: D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D010738:Type C Phospholipases