Decreased numbers of lymphocyte beta 2-adrenoceptors in pregnant women receiving beta 2-adrenergic agonist therapy.
Intravenous infusion of buphenine hydrochloride was administered on 4 successive days to 8 pregnant women with imminent preterm labor. Serial blood samples taken before and throughout the study were assayed for lymphocyte beta 2-adrenoceptor density and cyclic adenosine-3',5'-monophosphate (cAMP). The lymphocyte beta 2-adrenoceptor density declined significantly (p less than 0.01) during the treatment. The plasma cAMP concentration was highest 4 h after commencement of infusion and decreased thereafter. Despite the decrease in lymphocyte beta 2-adrenoceptor density, the clinical response remained good and the parturients did not go into labor until several days after infusion was started.
Santala
M
M
Department of Obstetrics and Gynecology, Kuopio University Central Hospital, Finland.
Saarikoski
S
S
Castrén
O
O
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000328:Adult; D000242:Cyclic AMP / Q000097:blood; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D009756:Nylidrin / Q000494:pharmacology*; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D011247:Pregnancy; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; D009756:Nylidrin; D000242:Cyclic AMP