A new synthetic pentasaccharide with increased anti-factor Xa activity: possible role for anionic clusters in the interaction of heparin and antithrombin III.
Petitou
M
M
Sanofi Recherche-Institut Choay, Gentilly, France.
Lormeau
J C
JC
Choay
J
J
D000990:Antithrombin III / Q000378:metabolism*; D001665:Binding Sites; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D065427:Factor Xa Inhibitors; D006493:Heparin / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000494:pharmacology*; D011485:Protein Binding; D013329:Structure-Activity Relationship
D065427:Factor Xa Inhibitors; D009844:Oligosaccharides; C049714:IC 831423; D000990:Antithrombin III; D006493:Heparin