[Hemoperfusion via cryopreserved tissue fragments of xenogeneic spleen in suppurative-septic states in urology].
Hemoperfusion through cryopreserved fragments of porcine xenospleen tissue was used in combined treatment of 42 patients with pyoseptic urologic diseases: urosepsis, purulent intoxication due to acute pyelonephritis, pyoinflammatory scrotal and prostatic lesions (in 15, 19, 8 patients, respectively). Indications and contraindications are specified. Altogether 57 sessions were performed. Seventeen patients underwent the perfusion pre- and postoperatively, twenty-five in combination with chemotherapy. After the removal porcine spleen was dissected, treated with cryoprotective mixture (-196 degrees C) and placed into liquid nitrogen. One-year viability of the tissue retained in 82-93% of the samples. Duration of the hemoperfusion was 40-80 min, the rate--30-40 ml/min. Two-four columns with cryopreserved tissue were utilized which were alternately connected with the circuit. Heparinization reached 12,000-15,000 units. All the patients survived. Positive clinical and laboratory findings were obtained for 38 patients (90%). Urine and blood samples appeared sterile on day 7-12. The improvement of the severe condition of the patients is attributed to detoxication, immunostimulation and immunocorrective effects.
Koblov
N L
NL
Suskova
V S
VS
Perepanova
T S
TS
Onishchenko
N A
NA
Danilkov
A P
AP
Orzhekhovskaia
I G
IG
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D003131:Combined Modality Therapy; D015925:Cryopreservation; D005069:Evaluation Studies as Topic; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D013154:Spleen; D013552:Swine; D014552:Urinary Tract Infections / Q000276:immunology / Q000628:therapy*
Gemoperfuziia cherez kriokonservirovannye fragmenty tkani ksenoselezenki pri gnoĭno-septicheskikh sostoianiiakh v urologii.