Neuroblastoma in a dwarfed newborn. Possible clue to the chromosomal localization of the gene for achondroplasia?
The authors report a premature achondroplastic child with connatal neuroblastoma. Though this association could be coincidental, we suggest that a microdeletion inducing a contiguous gene syndrome involving the locus of neuroblastoma suppressor gene could be an alternative hypothesis. The gives a working hypothesis for the localization of the gene for achondroplasia.
Verloes
A
A
Centre for Human Genetics, CHU Sart Tilman, Liége, Belgium.
Massart
B
B
Jossa
V
V
Langhendries
J P
JP
Hainaut
H
H
Paquot
J P
JP
Koulischer
L
L
D000130:Achondroplasia / Q000150:complications / Q000151:congenital / Q000235:genetics*; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D004200:Diseases in Twins; D016147:Genes, Tumor Suppressor; D008040:Genetic Linkage; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000235:genetics*; D008297:Male; D009447:Neuroblastoma / Q000150:complications / Q000151:congenital* / Q000235:genetics; D013899:Thoracic Neoplasms / Q000150:complications / Q000151:congenital* / Q000235:genetics; D014429:Twins, Dizygotic