title: [The inhalation 1 concentration test for the assessment of bronchial reactivity].
abstract: An unspecific bronchial provocation challenge with a 1-concentration test is a reliable method to distinguish between normal and hyperreactive persons. The patient inhales a bronchoconstricting substance such as methacholine. A significant change of lung function, for example an increase of airway resistance, characterizes a hyperreactive bronchial system. The continuous registration of transcutaneous oxygen pressure is helpful concerning a strong reaction or a peripheral airway obstruction. An exaggerated increase of airway resistance after provocation test can be treated rapidly by inhalation of sympathicomimetics. No complications were registered. Comparative studies showed a good reproducibility of this method. Summarizing, the 1-concentration test is simple, easy to perform and suitable especially for investigations in occupational medicine or epidemiology.
authors.affiliation: Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin (BGFA), Ruhr-Universität Bochum.
authors.forename: H P
authors.initials: HP
authors.lastname: Hoffarth
authors.forename: W
authors.initials: W
authors.lastname: Reier
authors.forename: G
authors.initials: G
authors.lastname: Reichel
authors.forename: W T
authors.initials: WT
authors.lastname: Ulmer
mesh_terms: D000403:Airway Resistance / Q000187:drug effects*; D016535:Bronchial Hyperreactivity / Q000175:diagnosis*; D001985:Bronchial Provocation Tests / Q000379:methods*; D006801:Humans; D008688:Methacholine Compounds; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D008688:Methacholine Compounds
vernacular_title: Der inhalative 1-Konzentrationstest zur Uberprüfung der bronchialen Reagibilität.