title: First case in Tunisia of PH1 positive chronic myelogenous leukemia in a 3 year old child.
abstract: The first case in Tunisia of a 3 year old child with adult type chronic myelogenous leukemia is presented. Diagnosis was based on clinical and biological presentation and detection of Philadelphia (PH1) chromosome. Chronic myelogenous leukemia in children represents 3.8% of all cases of chronic myelogenous leukemia detected in Tunisia between 1970 and 1990. Only one 3.5 year old case was reported without PH1 chromosome.
authors.affiliation: Laboratoire d'Hématologie Hôpital des Enfants, Tunis.
authors.forename: N H
authors.initials: NH
authors.lastname: Toumi
authors.forename: H
authors.initials: H
authors.lastname: Ben Abid
authors.forename: B
authors.initials: B
authors.lastname: Meddeb
authors.forename: T
authors.initials: T
authors.lastname: Ben Othman
authors.forename: C
authors.initials: C
authors.lastname: Trabelsi
authors.forename: K
authors.initials: K
authors.lastname: Boukef
authors.forename: A
authors.initials: A
authors.lastname: Hafsia
mesh_terms: D000367:Age Factors; D000493:Allopurinol / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D015994:Incidence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D014416:Tunisia / Q000453:epidemiology
chemical_list: D000493:Allopurinol; D006918:Hydroxyurea