Cutaneous polyarteritis nodosa associated with Crohn's disease. Report and review of the literature.
A 31-year-old white woman with biopsy verified cutaneous polyarteritis nodosa diagnosed in 1981, developed 6 years later recurrent abdominal pains, rectal bleeding and weight loss. Barium enema demonstrated typical changes of Crohn's disease with fistula in the terminal ileum. Her resected ileum showed granulomatous transmural ileitis without vasculitis. Only corticosteroids and cyclophosphamide controlled the cutaneous and the gastrointestinal symptoms until she was treated with sulfasalazine. The association between cutaneous polyarteritis nodosa and Crohn's disease is discussed and the treatment of earlier reported cases is reviewed.
Gudbjörnsson
B
B
Department of Internal Medicine, Uppsala University Hospital, Sweden.
Hällgren
R
R
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003424:Crohn Disease / Q000150:complications* / Q000473:pathology / Q000601:surgery; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007082:Ileum / Q000473:pathology / Q000601:surgery; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012867:Skin / Q000098:blood supply* / Q000473:pathology; D012460:Sulfasalazine / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D012460:Sulfasalazine; D003520:Cyclophosphamide