Sequence similarity between part of human retinoblastoma susceptibility gene product and a neurofilament protein subunit.
Retinoblastoma, is a highly malignant but readily treatable cancer of the retina, which occurs at an incidence of 1 in 20,000 live births in young children. The retinoblastoma gene that determines susceptibility to this cancer encodes a nuclear phosphoprotein which has been extensively characterized. Yet, to this date, its function remains unknown. We report here that RB amino acids 307-435 shows similarity to the rod domain of the neurofilament L-type subunit (NF-L).
Hong
F
F
Center for Molecular Medicine/Institute of Biotechnology, University of Texas Health Science Center, San Antonio 78245.
Lee
W H
WH
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D034882:Lamins; D008969:Molecular Sequence Data; D016900:Neurofilament Proteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D011487:Protein Conformation; D016160:Retinoblastoma Protein / Q000737:chemistry* / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
D034882:Lamins; D016900:Neurofilament Proteins; D009687:Nuclear Proteins; D016160:Retinoblastoma Protein