[Molecular pathological diagnosis of cancer].
Molecular biological analysis plays an important role for understanding of cancer pathogenesis. For example, accumulation of oncogene and anti-oncogene changes is necessary for cancer development. Molecular pathology is defined as a study field examining clinical materials using molecular biological technique. Even though mechanisms of cancer development and progression has much complexity, molecular pathological findings give a crucial information on clinical medicine, as Ki-ras point mutation and certain allelic loss may convert colon adenoma into carcinoma. Overexpression of EGF/receptor in gastric cancer is a biologic marker for high malignancy. More accumulation of molecular pathological informations will provide a new approach for prospective molecular diagnosis.
Yasui
W
W
1st Dept. of Pathology, Hiroshima University School of Medicine.
Tahara
E
E
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D003110:Colonic Neoplasms / Q000235:genetics / Q000473:pathology; D066246:ErbB Receptors / Q000235:genetics; D005784:Gene Amplification; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D009857:Oncogenes; D012150:Polymorphism, Restriction Fragment Length; D012175:Retinoblastoma / Q000235:genetics / Q000473:pathology; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology
D066246:ErbB Receptors