Active immunization against bioregulators: behavioural and catecholamine changes in albino rats immunized against sydnophen.
Active immunization of white rats against the catecholamine analogue, sydnophen, results in physiological changes extending over two months. The levels of noradrenaline in blood, and dopamine in brain, were depressed, some behavioural activities were reduced and alcohol consumption was lowered. On this basis, active immunization against various bioregulators--a method of inverse regulation--shows promise as a method for achieving long-term adjustment of physiological status.
Ashmarin
I P
IP
School of Biology, Moscow State University.
Danilova
R A
RA
Mashkovskii
M D
MD
Mel'nik
E I
EI
Obukhova
M F
MF
Sagimbaeva
Sh K
ShK
Tsirenina
M L
ML
D000428:Alcohol Drinking; D000818:Animals; D000917:Antibody Formation; D000928:Antidepressive Agents / Q000276:immunology; D001007:Anxiety; D001362:Avoidance Learning; D001522:Behavior, Animal; D001923:Brain Chemistry; D003216:Conditioning, Operant; D004298:Dopamine / Q000032:analysis*; D004924:Escape Reaction; D005106:Exploratory Behavior; D007114:Immunization; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D051381:Rats; D013558:Sydnones / Q000276:immunology*; D009435:Synaptic Transmission
D000928:Antidepressive Agents; D013558:Sydnones; C013271:sydnophen; D004298:Dopamine; D009638:Norepinephrine