In vitro neurotoxicity study with dorsal root ganglia for acrylamide and its derivatives.
Acrylamide and 6 derivatives inhibited neurite growth from rat dorsal root ganglion in culture. The half-maximum inhibition concentration (I50) varied among test compounds, ranging from 0.8 mM for acrylamide and N-hydroxymethylacrylamide to 30 mM for methacrylamide. The value correlated well with the acute oral LD50 for rats, the linear regression equation being I50 = 2.74LD50-6.52 (r = 0.897, P less than 0.05), but did not correlate with in vivo neurotoxicity for mice. Log (1/I50) was a linear function of the rate constant with glutathione (K), i.e. log (1/I50) = 0.828logK + 0.056 (r = 0.938, P less than 0.05).
Tanii
H
H
Department of Hygiene, School of Medicine, Kanazawa University, Japan.
Hashimoto
K
K
D000178:Acrylamides / Q000009:adverse effects* / Q000633:toxicity; D000284:Administration, Oral; D000818:Animals; D002493:Central Nervous System Diseases / Q000139:chemically induced; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D007928:Lethal Dose 50; D051381:Rats; D014018:Tissue Distribution
D000178:Acrylamides; D005978:Glutathione; C066443:N-methylolacrylamide