Concurrent chemotherapy and thoracic irradiation in non-small cell lung cancer.
Do results from recently reported phase II trials of combination chemotherapy and concurrent radiation warrant evaluation in a randomized study? Our bias is that only treatment regimens associated with a twofold increase in median survival should be considered for a phase III trial increase in median survival. Therefore, for stage IIIA N2 NSCLC patients median survival should increase from 12 to 24 months, and for stage IIIB patients, it should increase from 9 to 18 months. Although survival results from some combined modality trials are encouraging, thus far no concurrent chemotherapy-radiation regimen appears to have produced the preceding results.
Bonomi
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Section of Medical Oncology, Rush University Medical Center, Chicago, Illinois.
Reddy
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S
Faber
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LP
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008920:Misonidazole / Q000627:therapeutic use; D009362:Neoplasm Metastasis; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D015996:Survival Rate
D000970:Antineoplastic Agents; D008920:Misonidazole; D002945:Cisplatin; D005472:Fluorouracil