title: Comparison of gene expression of the dopamine D-2 receptor and DARPP-32 in rat brain, pituitary and adrenal gland.
abstract: In situ hybridization histochemistry was used to compare the distribution of dopamine D-2 receptor mRNA and DARPP-32 mRNA in rat brain, pituitary and adrenal gland. In many regions such as the caudate nucleus, nucleus accumbens and olfactory tubercle, there was an excellent correlation with dopamine receptor binding studies, whereas in some discrete brain regions mismatches were observed.
authors.affiliation: Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Schalling
authors.forename: A
authors.initials: A
authors.lastname: Dagerlind
authors.forename: M
authors.initials: M
authors.lastname: Goldstein
authors.forename: M
authors.initials: M
authors.lastname: Ehrlich
authors.forename: P
authors.initials: P
authors.lastname: Greengard
authors.forename: T
authors.initials: T
authors.lastname: Hökfelt
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000311:Adrenal Glands / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry / Q000187:drug effects*; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D015870:Gene Expression; D006651:Histocytochemistry; D008636:Mesencephalon / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009693:Nucleic Acid Hybridization; D010750:Phosphoproteins; D010902:Pituitary Gland / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000096:biosynthesis / Q000235:genetics
chemical_list: D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D012333:RNA, Messenger; D011954:Receptors, Dopamine; D014446:Tyrosine 3-Monooxygenase; D000262:Adenylyl Cyclases