Sequence-specific DNA binding by the v-erbA oncogene protein of avian erythroblastosis virus.
The v-erbA oncogene, a transduced copy of a thyroid hormone receptor, plays an important role in establishment of the transformed cell phenotype induced by avian erythroblastosis virus. The ability of thyroid hormone receptors to bind to specific sites on chromatin and to thereby modify the expression of adjacent target genes is a crucial element in their mechanism of action in the normal cell. The v-erbA protein also bound at high affinity to a set of DNA fragments recognized by the rat thyroid hormone receptor, but the relative affinity of the v-erbA protein for the different binding sites was distinct from that previously reported for the thyroid hormone receptors.
Bonde
B G
BG
Department of Microbiology, University of California, Davis 95616.
Privalsky
M L
ML
D001355:Alpharetrovirus / Q000235:genetics*; D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D001667:Binding, Competitive; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002645:Chickens; D004247:DNA / Q000378:metabolism*; D007700:Kinetics; D018774:Oncogene Proteins v-erbA; D009857:Oncogenes; D009994:Osmolar Concentration; D011485:Protein Binding; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015682:Retroviridae Proteins, Oncogenic / Q000378:metabolism*; D012965:Sodium Chloride / Q000494:pharmacology
D018774:Oncogene Proteins v-erbA; D015682:Retroviridae Proteins, Oncogenic; D012965:Sodium Chloride; D004247:DNA; D011505:Protein-Tyrosine Kinases