[The biological action of Yersinia pseudotuberculosis endotoxin].
Experimental studies on guinea pigs have shown that Y. pseudotuberculosis lipopolysaccharide is capable of inducing endotoxinemia accompanied by the development of the thrombohemorrhagic syndrome. In cases of pseudotuberculosis the importance of the increased synthesis of prostaglandins and cyclic nucleotides with the prevalence of PGF2 alpha and cGMP in the genesis of toxico-allergic manifestations of pathologic processes has been established. The pathomorphological picture of pseudotuberculosis endotoxinemia is characterized by sludge, the vascular thrombosis of the microcirculatory bed, diapedetic hemorrhages, delymphatization of the immunogenetic organs. The moderately pronounced action of indomethacin, a prostaglandin inhibitor, on the manifestations of pseudotuberculosis endotoxinemia has been revealed.
Isachkova
L M
LM
Prokopenkova
A P
AP
Plekhova
N G
NG
Gorshkova
R P
RP
D000818:Animals; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D004353:Drug Evaluation, Preclinical; D004731:Endotoxins / Q000633:toxicity*; D006168:Guinea Pigs; D007213:Indomethacin / Q000627:therapeutic use; D008070:Lipopolysaccharides / Q000633:toxicity; D011453:Prostaglandins / Q000097:blood; D013997:Time Factors; D015011:Yersinia pseudotuberculosis / Q000472:pathogenicity; D015012:Yersinia pseudotuberculosis Infections / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000473:pathology
D004731:Endotoxins; D008070:Lipopolysaccharides; D011453:Prostaglandins; D000242:Cyclic AMP; D006152:Cyclic GMP; D007213:Indomethacin
K voprosu o biologicheskom deĭstvii éndotoksina Yersinia pseudotuberculosis.