Aging does not alter muscarinic receptor-mediated inhibition of cyclic AMP formation in the striatum and hippocampus.
The effects of aging on the inhibition of forskolin-stimulated cyclic AMP formation by muscarinic receptors were investigated. There were no detectable changes in the magnitude of maximal inhibition by carbamylcholine or the potency of the agonist in inducing this response in either the striatum or hippocampus obtained from young or old Fisher 344 rats.
Abdallah
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Department of Pharmacology and Toxicology, University of Maryland School of Pharmacy, Baltimore 21201.
Pou
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el-Fakahany
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D000375:Aging; D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011916:Rats, Inbred F344; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*
D011976:Receptors, Muscarinic; D002217:Carbachol; D000242:Cyclic AMP