Translocation (Y;19)(q12;q13) and azoospermia.
An azoospermic male with a 46,X,t(Y;19)(q12;q13) karyotype is described. The comparison with 12 similar cases reveals that the Y breakpoints are usually on the long arm whereas the autosomal ones seem to be at random. Since a premeiotic origin is inconsistent with the arrest at diakinesis seen in those cases with meiotic studies, we postulate that a balanced t(Y;A) arises either via a chromatid exchange in the meiotic interphase or through a chromosome exchange in spermiogenesis or at the one cell stage of the zygote.
Diaz-Castaños
L R
LR
División de Genética, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco.
Rivera
H
H
Gonzalez-Montes
R M
RM
Diaz
M
M
D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002888:Chromosomes, Human, Pair 19 / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008540:Meiosis; D009845:Oligospermia / Q000235:genetics*; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D013091:Spermatogenesis; D014178:Translocation, Genetic; D014998:Y Chromosome / Q000648:ultrastructure*