Differential interference of alpha, beta or gamma interferons with HTLV-I integration and expression in vitro.
Alpha, beta and gamma interferons (IFNs) can exert a powerful and direct antiviral activity against HTLV-I and can also modulate positively some cell-mediated immune functions of the host cell. These multiple effects of IFNs can induce a long-lasting inhibition of viral infection in recipient cells, probably by "priming" the host cell to an active antiviral competence. It has to be underlined that each IFN was active differentially on the replicative cycle of HTLV-I, thus suggesting the possibility of a complementary action of IFNs in inhibiting HTLV-I infection. This might be relevant to a possible therapeutical approach for prevention of HTLV-I related diseases.
D'Onofrio
C
C
Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi Tor Vergata, Rome, Italy.
Alvino
E
E
Peci
E
E
Caliò
R
R
Bonmassar
E
E
D002478:Cells, Cultured; D005312:Fetal Blood / Q000166:cytology; D015967:Gene Expression Regulation, Viral / Q000235:genetics*; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D016899:Interferon-beta / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D011994:Recombinant Proteins; D016662:Virus Integration / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects
D007370:Interferon Type I; D011994:Recombinant Proteins; D016899:Interferon-beta; D007371:Interferon-gamma