Selective effects of low doses of apomorphine on spatiotemporal contrast sensitivity in healthy volunteers: a double-blind placebo-controlled study.
1. Apomorphine (1 and 5 micrograms kg-1) and placebo were given to nine normal volunteers, using a Latin-square design and double-blind procedures. The visual perception of static and moving patterns (static and motion contrast sensitivity) was evaluated before and 15 min after the dose administration. 2. Apomorphine (1 and 5 micrograms kg-1), as compared with placebo, led to a significant overall reduction of the visual perception of movement. This effect was dose-related, and apomorphine (5 micrograms kg-1) induced a more pronounced decrease in the visual perception of movement than apomorphine (1 microgram kg-1). With apomorphine (5 micrograms kg-1), the reduction was more pronounced for low spatial frequencies, and was linearly inversely correlated to the spatial frequency for a temporal frequency of 3 Hz. Finally, no significant effect of apomorphine was observed for sensitivity to static patterns. 3. Several non exclusive hypotheses may be suggested: The effects of apomorphine may result from stimulation of retinal D1- and/or D2-dopaminergic receptors. Apomorphine may increase the surround inhibition of ganglion cells' receptive-fields. This modification of the centre-surround balance may explain the decrease in contrast sensitivity for low spatial frequencies. The specific effects of apomorphine on the visual perception of movement support the hypothesis that apomorphine preferentially affects the magnocellular pathway which mediates sensitivity to moving patterns.
Blin
O
O
Centre de Pharmacologie Clinique et d'Evaluations Thérapeutiques, CHU Timone, Marseille, France.
Mestre
D
D
Masson
G
G
Serratrice
G
G
D000328:Adult; D001058:Apomorphine / Q000494:pharmacology*; D015350:Contrast Sensitivity / Q000187:drug effects*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D012684:Sensory Thresholds / Q000187:drug effects; D013028:Space Perception / Q000187:drug effects; D013998:Time Perception / Q000187:drug effects
D001058:Apomorphine