title: [Histopathological study of the esophageal injury induced by high-dose-rate intracavitary irradiation].
abstract: The histopathological responses of the rabbit esophagus to high-dose-rate intracavitary irradiation were investigated. After 5, 10 or 15 Gy irradiation using a remote afterloading system, the rabbits were sacrificed on different occasions. The esophagus was excised from each animal and examined histopathologically. Esophageal ulcer was observed 7 to 28 days after the irradiation of the highest dose. Edema and cell infiltration in the lamina propria proceeded mucosal changes like ulcer. Chronic injuries such as mucosal necrosis were seen at 6 months.
authors.affiliation: Department of Radiology, Kobe University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Soejima
authors.forename: T
authors.initials: T
authors.lastname: Kushima
authors.forename: A
authors.initials: A
authors.lastname: Kodama
authors.forename: T
authors.initials: T
authors.lastname: Sakaguchi
authors.forename: K
authors.initials: K
authors.lastname: Yonezawa
authors.forename: T
authors.initials: T
authors.lastname: Hashimura
authors.forename: K
authors.initials: K
authors.lastname: Imanaka
authors.forename: M
authors.initials: M
authors.lastname: Sako
authors.forename: M
authors.initials: M
authors.lastname: Kono
mesh_terms: D000818:Animals; D001918:Brachytherapy / Q000009:adverse effects*; D004947:Esophagus / Q000473:pathology / Q000528:radiation effects*; D011817:Rabbits; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology*