title: Severe cholestatic jaundice associated with piroxicam.
abstract: A 62-year-old man with rheumatoid arthritis developed jaundice while taking piroxicam. A full evaluation including ultrasound, computerized tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic cholestasis. The patient's jaundice and all other liver function abnormalities normalized 4 months after he discontinued taking piroxicam. This is the first case report in the United States of severe liver toxicity associated with piroxicam. The six cases in the English-language literature are reviewed, featuring the presentation, patterns of liver injury, and outcome in each. Piroxicam should be considered as a potential cause of cholestatic jaundice when other more common etiologies have been excluded.
authors.affiliation: Department of Medicine, Baylor College of Medicine, Houston, Texas.
authors.forename: K S
authors.initials: KS
authors.lastname: Hepps
authors.forename: G M
authors.initials: GM
authors.lastname: Maliha
authors.forename: R
authors.initials: R
authors.lastname: Estrada
authors.forename: R W
authors.initials: RW
authors.lastname: Goodgame
mesh_terms: D001706:Biopsy; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010894:Piroxicam / Q000009:adverse effects*
chemical_list: D010894:Piroxicam