[Pauciarticular juvenile chronic arthritis].
On basis of clinical and immunogenetic factors most children with pauciarticular juvenile chronic arthritis can be included in one of the subtypes: type 1 and type 2 pauciarticular JCA. Type 1 occurs in young children, mainly girls, with involvement of knees, ankles or elbows. In the majority of children antinuclear antibodies can be detected. The presence of these autoantibodies is associated with chronic anterior uveitis. Type 2 or the juvenile spondylarthropathies include morbus Bechterew, the reactive arthritides and arthritis associated with psoriasis and inflammatory bowel diseases. Large joints of the lower extremities are involved, back pain is unusual at onset, but enthesitis is frequently present. There is a strong association with HLA-B27. Treatment of both subsets consists of non-steroidal anti-inflammatory drugs, application of intra-articular steroids, physio- and hydrotherapy and splinting. In children with a polyarticular course of type 1, or a prolonged course of type 2 disease modifying drugs are often needed.
Hertzberger-ten Cate
R
R
Juliana Kinderziekenhuis, Academisch Ziekenhuis Leiden.
Fiselier
T
T
D001171:Arthritis, Juvenile / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D015535:Arthritis, Psoriatic / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D006130:Growth Disorders / Q000150:complications; D006801:Humans; D015863:Iridocyclitis / Q000150:complications; D013167:Spondylitis, Ankylosing / Q000628:therapy
Pauciarticulaire juveniele chronische arthritis.