title: Esters of 7-(diphenylmethylene)bicyclo[2.2.1]heptan-2-endo-ol with antiarrhythmic and other activities.
abstract: The synthesis of esters derived from 7-(diphenylmethylene)bicyclo[2.2.1]heptan-2-endo-ol, obtained by LiAlH4 reduction of 7-(diphenylmethylene)bicyclo[2.2.1]heptan-2-one, is described. Some of these esters showed an appreciable antiarrhythmic activity in rats, as well as moderate hypotensive and local anesthetic activities in rats and mice, respectively.
authors.affiliation: Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Longobardi
authors.forename: A
authors.initials: A
authors.lastname: Bargagna
authors.forename: E
authors.initials: E
authors.lastname: Mariani
authors.forename: P
authors.initials: P
authors.lastname: Schenone
authors.forename: S
authors.initials: S
authors.lastname: Russo
authors.forename: C
authors.initials: C
authors.lastname: De Paola
authors.forename: L
authors.initials: L
authors.lastname: Stella
authors.forename: D
authors.initials: D
authors.lastname: Donnoli
authors.forename: C
authors.initials: C
authors.lastname: Falzarano
authors.forename: E
authors.initials: E
authors.lastname: Marmo
mesh_terms: D000157:Aconitine / Q000494:pharmacology; D000758:Anesthesia; D000779:Anesthetics, Local / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D004952:Esters; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009636:Norbornanes / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013055:Spectrophotometry, Infrared
chemical_list: D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D004952:Esters; D009636:Norbornanes; C071415:7-(diphenylmethylene)bicyclo(2.2.1)heptan-2-ol; D000157:Aconitine