title: Functional analysis of the fsoC gene product of the F7(1) (fso) fimbrial gene cluster.
abstract: Contrary to what would be expected from data in the literature, mutations in the fsoC gene of the F7(1) (fso) P-fimbrial gene cluster do not completely block fimbrial biogenesis. fsoC mutants still express small amounts of fimbriae of normal length, which carry the non-adhesive minor subunit protein, FsoE, but lack the adhesin, FsoG. The FsoC protein operates at the same stage in fimbrial biogenesis as the FsoF and FsoG proteins. The data suggest that FsoC, FsoF and FsoG interact to form an initiation complex for fimbrial biogenesis.
authors.affiliation: Department of Molecular Cell Biology, University of Utrecht, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: Riegman
authors.forename: D
authors.initials: D
authors.lastname: Acton
authors.forename: R
authors.initials: R
authors.lastname: Sakkers
authors.forename: I
authors.initials: I
authors.lastname: van Die
authors.forename: W
authors.initials: W
authors.lastname: Hoekstra
authors.forename: H
authors.initials: H
authors.lastname: Bergmans
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002874:Chromosome Mapping; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism / Q000648:ultrastructure; D036781:Fimbriae Proteins; D010861:Fimbriae, Bacterial / Q000378:metabolism* / Q000648:ultrastructure; D005798:Genes, Bacterial; D006384:Hemagglutination; D005810:Multigene Family; D009154:Mutation; D010957:Plasmids
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C022924:colonization factor antigens; D036781:Fimbriae Proteins