title: On the mechanism of the anti-inflammatory activity of some copper (II) complexes.
abstract: The mechanism of the antiinflammatory activity of three copper(II) complexes: tetrachlorocuprate(II) of bis(2.4.6-trimethylpyridinio), tetrachlorocuprate(II) of bis(2.4-dimethylpyridinio) and tetrachlorocuprate(II) of bis-pyridinio, has been investigated. The antiinflammatory activity does not seem to be related to an inhibitory effect on prostaglandin biosynthesis or with leukocyte migration into inflamed tissue. These complexes showed an inhibitory effect on volume exudate in experimental pleurisy. They showed also a potent inhibitory effect on the production of superoxide anions. These inhibitory effects could explain, at least in part, their antiinflammatory activity.
authors.affiliation: Departamento de Farmacologia, Universidad de Navarra, Pamplona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Frechilla
authors.forename: B
authors.initials: B
authors.lastname: Lasheras
authors.forename: M
authors.initials: M
authors.lastname: Ucelay
authors.forename: E
authors.initials: E
authors.lastname: Parrondo
authors.forename: G
authors.initials: G
authors.lastname: Craciunescu
authors.forename: E
authors.initials: E
authors.lastname: Cenarruzabeitia
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002464:Cell Migration Inhibition; D003300:Copper / Q000494:pharmacology*; D015232:Dinoprostone / Q000096:biosynthesis; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D008297:Male; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010998:Pleurisy / Q000139:chemically induced / Q000378:metabolism; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013481:Superoxides / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009942:Organometallic Compounds; D011725:Pyridines; D013481:Superoxides; C067754:bis(pyridinio)dichlorocuprate(II); C067753:bis(2,4,6-trimethylpyridinio)dichlorocuprate(II); C067755:bis(2,4-dimethylpyridinio)dichlorocuprate(II); D003300:Copper; D015232:Dinoprostone; D007213:Indomethacin