Abnormalities of T cell immunoregulation in hemorrhagic fever with renal syndrome.
The functions of spontaneous suppressor T cells and T lymphocyte subsets in patients with hemorrhagic fever with renal syndrome were compared. In the early stages of disease, decreased activity of spontaneous suppressor T cells was concurrent with increased numbers of CD8+ cells and a reversed CD4:CD8 ratio. These changes were related to abnormalities in serum C3 level and circulating immune complexes. In the recovery stages of the illness, spontaneous suppressor T cell activity and T cell subsets returned to normal levels.
Chen
L B
LB
Department of Infectious Diseases, Second Teaching Hospital, Fourth Military Medical University, Xian, People's Republic of China.
Yang
W S
WS
D000936:Antigen-Antibody Complex / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D006476:Orthohantavirus / Q000276:immunology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007700:Kinetics; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D012044:Regression Analysis; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007074:Immunoglobulin G