title: A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin.
abstract: Three cytoplasmic proteins, called catenins, bind to the cytoplasmic tail of the epithelial cell-cell adhesion molecule E-cadherin. The complementary DNA sequence was determined for the 92-kilodalton beta catenin of Xenopus laevis. The sequence is homologous to mammalian plakoglobin, a protein of desmosomal and zonula adherens cell junctions, and to the plakoglobin homolog in Drosophila melanogaster, the product of the segment polarity gene armadillo. A monoclonal antibody to bovine plakoglobin recognizes the analogous beta catenin in the Madin-Darby canine kidney (MDCK) cell line. Armadillo plakoglobin may link E-cadherin to the underlying actin cytoskeleton at cell-cell junctions; the E-cadherin-catenin protein complex may also participate in the transmission of developmental information.
authors.affiliation: Department of Pharmacology, University of California, San Francisco 94143.
authors.forename: P D
authors.initials: PD
authors.lastname: McCrea
authors.forename: C W
authors.initials: CW
authors.lastname: Turck
authors.forename: B
authors.initials: B
authors.lastname: Gumbiner
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015820:Cadherins / Q000235:genetics*; D002460:Cell Line; D003598:Cytoskeletal Proteins / Q000235:genetics*; D004247:DNA / Q000235:genetics; D051180:Desmoplakins; D004331:Drosophila melanogaster / Q000235:genetics*; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D015534:Trans-Activators; D029867:Xenopus Proteins; D014982:Xenopus laevis; D051176:beta Catenin; D051185:gamma Catenin
chemical_list: C495266:CTNNB1 protein, Xenopus; D015820:Cadherins; D003598:Cytoskeletal Proteins; D051180:Desmoplakins; D015534:Trans-Activators; D029867:Xenopus Proteins; D051176:beta Catenin; D051185:gamma Catenin; D004247:DNA