title: PCR detection of distal Yp sequences in an XX true hermaphrodite.
abstract: An XX true hermaphrodite was examined for the presence of Y-specific sequences using Southern-blotting and polymerase chain reaction (PCR) techniques. Of 25 loci examined, only two, the proximal border of the pseudoautosomal region (PABY) and the sex determining region of the Y chromosome (SRY), were detected. A crossing over event in paternal meiosis, proximal to the SRY locus but distal to the zinc finger protein (ZFY) locus, presumably transferred to two loci to the X chromosome.
authors.affiliation: Department of Congenital Abnormalities Research, National Children's Medical Research Center, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagome
authors.forename: S
authors.initials: S
authors.lastname: Seki
authors.forename: K
authors.initials: K
authors.lastname: Fukutani
authors.forename: S
authors.initials: S
authors.lastname: Nagafuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Nakahori
authors.forename: T
authors.initials: T
authors.lastname: Tamura
mesh_terms: D000293:Adolescent; D000595:Amino Acid Sequence; D015139:Blotting, Southern; D003434:Crossing Over, Genetic / Q000235:genetics*; D012734:Disorders of Sex Development / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000235:genetics; D016133:Polymerase Chain Reaction; D012732:Sex Determination Analysis; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D009838:Oligodeoxyribonucleotides