Activity of pentamidine and pentamidine analogs against Toxoplasma gondii in cell cultures.
The capabilities of pentamidine and nine pentamidine analogs to inhibit the development of Toxoplasma gondii were examined in vitro. Treatment of infected cultures with pentamidine and five of its analogs caused a significant (P less than 0.05) reduction in the numbers of tachyzoites produced. Analogs of pentamidine may be useful agents in the treatment of toxoplasmosis.
Lindsay
D S
DS
Department of Pathobiology, College of Veterinary Medicine, Auburn University, Alabama 36849.
Blagburn
B L
BL
Hall
J E
JE
Tidwell
R R
RR
D000818:Animals; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D010419:Pentamidine / Q000031:analogs & derivatives / Q000494:pharmacology*; D014122:Toxoplasma / Q000187:drug effects*
D010419:Pentamidine