The relationship between some beta-adrenergic mediated responses and plasma concentrations of adrenaline and cyclic AMP in man.
To test the hypothesis that increments in plasma cyclic AMP during beta-adrenergic stimulation reflect integrated second messenger function of the tissues activated by the agonist, graded adrenaline infusion resulting in plasma adrenaline concentrations within the physiological range was performed in 8 healthy subjects with and without concomitant beta-adrenoceptor blockade by iv propranolol. A significant correlation was found between increments in plasma adrenaline and plasma cyclic AMP in the experiments without beta-blockade; during concomitant beta-blockade the increase in plasma cyclic AMP concentrations at low adrenaline infusion rates was prevented, whereas a small increase in cyclic AMP was found at high adrenaline infusion rates, probably owing to incomplete beta-receptor blockade. Likewise, the adrenaline-induced increments in blood substrates (glucose, lactate, glycerol and beta hydroxybutyric acid) were significantly reduced but not completely prevented by beta-blockade. We conclude that an altered relationship between beta-agonist concentrations and plasma cyclic AMP may provide evidence for the existence of differences in beta-adrenergic sensitivity in man.
Philipsen
E K
EK
Medical Department F, Glostrup Hospital, Denmark.
Myhre
J
J
Larsen
S
S
Damkjaer Nielsen
M
M
Holst
J J
JJ
Hilsted
J
J
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000097:blood*; D000242:Cyclic AMP / Q000097:blood*; D004837:Epinephrine / Q000008:administration & dosage* / Q000097:blood; D005934:Glucagon / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000378:metabolism; D011433:Propranolol / Q000008:administration & dosage; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D007328:Insulin; D011943:Receptors, Adrenergic, beta; D005934:Glucagon; D011433:Propranolol; D000242:Cyclic AMP; D004837:Epinephrine