Propranolol for intractable hemolysis after open heart operation.
Postoperative intravascular hemolysis occurring in 2 patients was alleviated by propranolol. One patient underwent mitral valve replacement and had development of intractable hemolysis due to a paravalvular leak. The other patient underwent ventricular septal defect closure and had hemolysis caused by the Dacron patch. Both patients were given oral propranolol, and the degree of hemolysis decreased substantially. Although the exact mechanism of the propranolol effect on mechanical intravascular hemolysis is unclear, propranolol is thought to reduce the shearing stress between erythrocytes and the foreign material by slowing the velocity of the circulation.
Okita
Y
Y
Department of Cardiovascular Surgery, Tenri Hospital, Japan.
Miki
S
S
Kusuhara
K
K
Ueda
Y
Y
Tahata
T
T
Yamanaka
K
K
D000743:Anemia, Hemolytic / Q000188:drug therapy / Q000209:etiology*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002675:Child, Preschool; D004912:Erythrocytes; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*; D019736:Prostheses and Implants / Q000009:adverse effects; D013314:Stress, Mechanical
D011433:Propranolol