Cyclic AMP and mechanisms of vasodilation.
Cyclic AMP and the mechanism of vasodilation have been reviewed by first discussing the enzymes involved (adenyl cyclase, cyclic nucleotide phosphodiesterases, cyclic AMP-dependent protein kinase) and then agents that increase cAMP in smooth muscle. Two mechanisms of vasodilation are described: (i) effects on contractile proteins; (ii) effects on Ca2+ levels. Evidence for compartments of cAMP is also presented.
Murray
K J
KJ
Department of Cellular Pharmacology, Smith Kline & French Research Ltd, Welwyn Herts, U.K.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*
D000242:Cyclic AMP