The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators.
Complex retroviruses, including Human Immunodeficiency Virus Type 1 (HIV-1), are characterized by the ordered temporal expression of the various viral gene products in infected cells. This effect is mediated by a novel class of RNA-sequence-specific regulatory proteins typified by the Rev trans-activator of HIV-1. Evidence suggests that Rev regulates HIV-1 gene expression by intervening in the normal pathway of eukaryotic mRNA processing and transport.
Cullen
B R
BR
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.
Malim
M H
MH
D001483:Base Sequence; D015967:Gene Expression Regulation, Viral / Q000235:genetics; D015757:Genes, rev / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D008969:Molecular Sequence Data; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics
D012333:RNA, Messenger