title: An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro.
abstract: Recordings were made from human hippocampal tissue surgically removed for treatment of epilepsy. In 70% of cases, an N-methyl-D-aspartate (NMDA) receptor-mediated component was present in excitatory synaptic input to gyrus dentatus. NMDA receptors are normally present, but do not participate in low-frequency synaptic transmission, in this region of the mammalian brain. These findings suggest that recruitment of normally dormant excitatory amino acid receptors may be a feature of the epileptic brain.
authors.affiliation: Department of Cell Biology, Duke University Medical Center, Durham, NC 27710.
authors.forename: L
authors.initials: L
authors.lastname: Urban
authors.forename: P G
authors.initials: PG
authors.lastname: Aitken
authors.forename: A
authors.initials: A
authors.lastname: Friedman
authors.forename: G G
authors.initials: GG
authors.lastname: Somjen
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000200:Action Potentials; D004558:Electric Stimulation; D004827:Epilepsy / Q000503:physiopathology*; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D066298:In Vitro Techniques; D010879:Piperazines / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D010879:Piperazines; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D015763:2-Amino-5-phosphonovalerate; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid