title: The plasma sex steroid binding protein (SBP or SHBG). A critical review of recent developments on the structure, molecular biology and function.
abstract: Significant developments have taken place within the past five years on the characterization, molecular biology and function of the plasma sex steroid-binding protein, SBP (or sex hormone binding globulin, SHBG). During the span of that time, amino acid sequences of two SBPs have been established, amino acid residues in the steroid-binding site have been identified, the structure of the human SBP gene has been deduced and evidence for the possible existence of a SBP membrane receptor has been presented. This review covers the salient aspects of these and other developments including a critical analysis of the various proposed models and interpretations with regards to the structure, evolution, molecular biology and function of SBP.
authors.affiliation: Department of Obstetrics & Gynecology, University of Washington, Seattle 98195.
authors.forename: P H
authors.initials: PH
authors.lastname: Petra
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D012738:Sex Hormone-Binding Globulin / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D012738:Sex Hormone-Binding Globulin