[In vitro antifungal activity of amorolfine against Malassezia species].
In vitro antifungal activities of a new morpholine agent, amorolfine (MT-861) were investigated, against 39 strains of Malassezia furfur (11 stock cultures and 28 clinical isolates) and 8 strains (stock cultures) of Malassezia pachydermatis, in comparison with those of 2 reference drugs, clotrimazole (CTZ) and bifonazole (BFZ). Of the 3 antifungal agents, MT-861 exhibited strongest antifungal activities against the stock cultures of M. furfur and M. pachydermatis with average MIC values of 0.428 and 0.174 micrograms/ml, respectively; and the average BFZ activity was less than 1/10, and the average CTZ activity was 1/100, of the average MT-861 activity. All of the clinical isolates of M. furfur also showed high susceptibilities, though they were more susceptible to BFZ and CTZ.
Uchida
K
K
Teikyo University Research Center for Medical Mycology.
Aoki
K
K
Yamaguchi
H
H
D000935:Antifungal Agents / Q000494:pharmacology*; D003022:Clotrimazole / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D008290:Malassezia / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009025:Morpholines / Q000494:pharmacology*
D000935:Antifungal Agents; D007093:Imidazoles; D009025:Morpholines; C038974:amorolfine; D003022:Clotrimazole; C036596:bifonazole