Pacemaker-like and other types of spontaneous membrane potential oscillations of thalamocortical cells.
During EEG-synchronized sleep, thalamic activity is characterized by rhythmic oscillations that till recently have been suggested to require the contribution of intra- and extra-thalamic inputs. The present experiments show that thalamocortical (TC) cells, mechanically and pharmacologically isolated from their intra-thalamic, cortical and brainstem inputs, are capable of different types of spontaneous membrane potential oscillations some of which resemble those observed in TC cells of the living animal during EEG-synchronization.
Leresche
N
N
Department of Pharmacology, St. George's Hospital Medical School, London, U.K.
Jassik-Gerschenfeld
D
D
Haby
M
M
Soltesz
I
I
Crunelli
V
V
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D005829:Geniculate Bodies / Q000187:drug effects / Q000502:physiology*; D008274:Magnesium / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology; D013788:Thalamus / Q000187:drug effects / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D013779:Tetrodotoxin; D015763:2-Amino-5-phosphonovalerate; D008274:Magnesium