title: Dose-dependent effects of an anabolic steroid, nandrolone phenylpropionate (Durabolin), on body composition and muscle protein metabolism in female rats.
abstract: The effects of three doses (1, 4 and 10 mg/kg body weight) of an anabolic steroid, nandrolone phenylpropionate (NPP), on body weight and composition, and muscle protein metabolism were investigated in female rats. Daily injections of 1 mg/kg of NPP for 10 days caused a significant increase in weight gain which was associated with an increase in body protein (9%) without affecting body fat. At higher doses this effect on body weight was attenuated, resulting in no change in body weight at 10 mg/kg. However body protein content was still increased (9%) whereas body fat content was significantly reduced (32%). NPP did not affect metabolizable energy intake at any dose tested. Body energy gain and gross energetic efficiency were both significantly reduced in animals treated with a dose of 10 mg/kg. The mass and protein content of gastrocnemius muscle were significantly increased in animals injected with NPP at all doses. Muscle protein synthesis measured in vivo was also significantly stimulated at 1 and 4 mg/kg but was not affected at 10 mg/kg. These data confirm an anabolic action of NPP and suggest highly dose-dependent effects on other parameters such as body weight, fat deposition and muscle protein synthesis.
authors.affiliation: Department of Nutrition, King's College, London, UK.
authors.forename: J J
authors.initials: JJ
authors.lastname: Choo
authors.forename: P W
authors.initials: PW
authors.lastname: Emery
authors.forename: N J
authors.initials: NJ
authors.lastname: Rothwell
mesh_terms: D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D009124:Muscle Proteins / Q000096:biosynthesis / Q000378:metabolism*; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D045930:Anabolic Agents; D009124:Muscle Proteins; D009277:Nandrolone; C008580:nandrolone phenpropionate