[The effect of the inhibition of free-radical oxidation processes in early postnatal ontogeny on learning in adult rats].
The effect on neonatal administration of synthetic antioxidant mexidol on avoidance conditioning was studied in 2-month old rats. The inhibition of the free-radical oxidation in the tissues of 3-7-day old rats considerably facilitated subsequent process of learning: the avoidance response latency was reduced by 4-6 times, the conditioned response was two-fold augmented, and total motor activity was reduced at the stage of a stable response.
Vishnevskaia
G V
GV
Gern
E I
EI
Adzhimolaev
T A
TA
D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D003864:Depression, Chemical; D005609:Free Radicals; D010084:Oxidation-Reduction / Q000187:drug effects; D010847:Picolines / Q000494:pharmacology; D011736:Pyridoxine / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D010847:Picolines; C070020:emoxypine succinate; D011736:Pyridoxine
Vliianie ingibirovaniia protsessov svobodnoradikal'nogo okisleniia v rannem postnatal'nom ontogeneze na obuchenie vzroslykh krys.