Trenbolone: application of the Ames test. Recent data.
The mutagenicity of trenbolone, a synthetic androgen, was studied in a number of genotoxicity tests using in vitro and in vivo systems for gene mutations, chromosomal mutations and primary DNA damage demonstration. Only 2 tests were found to be positive or dubious: the in vitro micronucleus test in SHE cells (however, this test was negative in 2 other cell lines: C3H and CHO cells) and the Ames test for 1 of the 5 studies which found a positive result in TA 100 strain without metabolic activation. Repetition of this study with pure trenbolone showed no genotoxic activity; trenbolone was therefore considered to be devoid of genotoxic activity.
Marzin
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Laboratoire de Toxicologie, Institut Pasteur de Lille, France.
D045930:Anabolic Agents / Q000633:toxicity*; D000818:Animals; D016466:CHO Cells; D002460:Cell Line; D006224:Cricetinae; D006367:HeLa Cells; D006801:Humans; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000187:drug effects; D014204:Trenbolone Acetate / Q000031:analogs & derivatives* / Q000633:toxicity
D045930:Anabolic Agents; D014204:Trenbolone Acetate