Pancreatitis after rectal administration of 5-aminosalicylic acid.
A patient treated with sulfasalazine for new-onset ulcerative colitis developed self-limited pancreatitis. Rechallenge with 5-aminosalicylic acid (5-ASA) in enema form (Rowasa) again induced pancreatitis. Recent case reports suggest that the salicylate component of sulfasalazine can lead to the development of pancreatitis with oral 5-ASA administration. This patient's course demonstrates further that rechallenge with 5-ASA in a rectal form may also lead to pancreatitis.
Isaacs
K L
KL
Department of Gastroenterology, University of North Carolina, Chapel Hill 27599-7080.
Murphy
D
D
D000285:Administration, Rectal; D000328:Adult; D000636:Aminosalicylic Acids / Q000008:administration & dosage* / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy; D005260:Female; D006801:Humans; D010195:Pancreatitis / Q000139:chemically induced*; D012460:Sulfasalazine / Q000009:adverse effects
D000636:Aminosalicylic Acids; D012460:Sulfasalazine