title: Chromosomal instability in breast cancer patients.
abstract: We have carried out cytogenetic studies, using the G-banding technique, in peripheral blood lymphocytes of 10 patients affected by breast carcinoma. The frequency of aberrant metaphases (7.36%) is significantly different from that of our laboratory controls (3.76% of aberrant metaphases) but not from that detected in patients suffering from bladder cancer (10.64%) and Hodgkin's disease (11.03%), two conditions that have previously been described as chromosomally unstable. Our results suggest that breast carcinoma patients show a degree of chromosomal instability that could be related to a predisposition to neoplastic disease.
authors.affiliation: Department de Biologia Cel.lular i Fisiologia, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Barrios
authors.forename: M R
authors.initials: MR
authors.lastname: Caballín
authors.forename: R
authors.initials: R
authors.lastname: Miró
authors.forename: C
authors.initials: C
authors.lastname: Fuster
authors.forename: F
authors.initials: F
authors.lastname: Guedea
authors.forename: A
authors.initials: A
authors.lastname: Subias
authors.forename: J
authors.initials: J
authors.lastname: Egozcue
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D006801:Humans; D007621:Karyotyping