GABA and tyrosine hydroxylase immunocytochemistry reveal different patterns of colocalization in retinal neurons of various vertebrates.
Colocalization of GABA- and tyrosine hydroxylase-like immunoreactivity was studied in the retinae of various vertebrate species in order to ascertain whether the presumed coexistence of GABA and dopamine, reported earlier for mammals (Kosaka et al.: Exp. Brain Res. 66:191-210, '87: Wässle and Chun: J. Neurosci. 8:3383-3394,'88) is a common phenomenon. GABA-immunopositive cells constituted a separate population from tyrosine hydroxylase-positive cells in fish and amphibians, whilst in higher--i.e., amniote--vertebrates, such as reptiles, birds, and mammals, all dopaminergic cells contained GABA-like immunoreactivity. No clear correlation was found between the type of dopaminergic cell (amacrine/interplexiform) and the presence or absence of colocalization.
Wulle
I
I
Institut für Anatomie und Zellbiologie, Philipps Universität Marburg, West Germany.
Wagner
H J
HJ
D000818:Animals; D002397:Catfishes; D002645:Chickens; D003058:Cockroaches; D051379:Mice; D012160:Retina / Q000166:cytology / Q000378:metabolism*; D013045:Species Specificity; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*; D014982:Xenopus laevis; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D014446:Tyrosine 3-Monooxygenase