The insulin A and B chains contain sufficient structural information to form the native molecule.
Refolding studies show that native insulin can be reformed from A and B chains only. This suggests that the A and B chains contain the necessary structural information and that the C peptide is not required for this process.
Wang
C C
CC
Division of Biochemistry and Biophysics, Food and Drug Administration, Bethesda, MD 20892.
Tsou
C L
CL
D000818:Animals; D007328:Insulin / Q000737:chemistry*; D011384:Proinsulin / Q000737:chemistry; D011487:Protein Conformation; D011489:Protein Denaturation
D007328:Insulin; D011384:Proinsulin