title: Pleomorphic xanthoastrocytoma with desmoplastic reaction: angiomatous variant. Report of two cases.
abstract: Two cases of cerebral pleomorphic xanthoastrocytomas (PXA-s) with prominent vascularity and desmoplastic changes occurring in young subjects are presented. The tumors displayed the marked pleomorphism characteristic of PXA-s and had variable cellularity. The cytoplasm of many tumor cells contained an abundance of lipid droplets. Most tumor cells were positive for glial fibrillary acidic protein. The unusual feature about these tumors was the presence of very large numbers of tiny blood vessels with variable thickness of their walls. In many areas the small vessels and the neoplastic astrocytes were in close proximity to each other, with capillaries adjacent to or protruding into tumor cell cytoplasm, reminiscent of the pattern seen in highly vascularized or "angiomatous" meningiomas. In other areas extensive fibrosis was seen. We feel that the latter, as in the cases of comparably vascular meningiomas, had its origin in congelation and secondary organization of plasma proteins that have exuded through leaky walls of newly formed blood vessels. These are the first reported cases of PXA with an angiogliomatous pattern.
authors.affiliation: Department of Pathology and Oncology, University of Kansas College of Health Sciences and Hospital, Kansas City 66103.
authors.forename: Y
authors.initials: Y
authors.lastname: Sugita
authors.forename: J J
authors.initials: JJ
authors.lastname: Kepes
authors.forename: M
authors.initials: M
authors.lastname: Shigemori
authors.forename: S
authors.initials: S
authors.lastname: Kuramoto
authors.forename: G
authors.initials: G
authors.lastname: Reifenberger
authors.forename: J C
authors.initials: JC
authors.lastname: Kiwit
authors.forename: W
authors.initials: W
authors.lastname: Wechsler
mesh_terms: D000328:Adult; D001253:Astrocytes / Q000473:pathology; D001254:Astrocytoma / Q000098:blood supply / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000098:blood supply / Q000473:pathology* / Q000601:surgery; D002196:Capillaries / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000473:pathology* / Q000601:surgery; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005909:Glioblastoma / Q000098:blood supply / Q000473:pathology* / Q000601:surgery; D006391:Hemangioma / Q000098:blood supply / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein