Measuring gene mutation in vivo.
Both chromosomal aberrations and intragenic mutations are important in the activation of oncogenes and inactivation of antioncogenes. It is now possible to measure both types of mutational events in vivo in a single cell type. The results obtained in both Chinese hamsters and rats are surprising: mutations can be induced in the absence of detectable chromosomal aberrations by some agents and vice versa by others. Preliminary results from a validation study are presented.
Heddle
J A
JA
Department of Biology, York University, Toronto, Ontario, Canada.
Khan
M A
MA
Urlando
C
C
Pagura
M E
ME
D000818:Animals; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens / Q000008:administration & dosage / Q000494:pharmacology; D009154:Mutation; D051381:Rats; D013866:Thioguanine / Q000494:pharmacology
D009153:Mutagens; D013866:Thioguanine