[The diagnostic importance of determining prostaglandins in patients with nephrogenic arterial hypertension].
The study included 15 patients with nephrogenic hypertension of various genesis. 13 of them had unilateral disease, 2 bilateral one. The diagnosis was established from the data provided by a single captopril test, radionuclide and angiographic examinations. The blood for renin and prostaglandin quantitation was obtained from the renal veins and infrarenal portion of the vena cava inferior. The results show that in unilateral renal lesions prostaglandin E secretion on the affected side was significantly lower than on the contralateral side (p less than 0.05). Plasma renin activity in 3 patients with a contracted kidney was significantly lower on the affected side (p less than 0.05), though the rest 10 patients were reported to exhibit opposite results. No significant relationships occurred in the levels of prostaglandins I2, F2 alpha, thromboxane A2. It is suggested that renal ischemia may inhibit synthesis of depressor prostaglandin E2 in renal medullary interstice. A separate analysis is presented of plasma renin and prostaglandin activity in 2 cases of nephrogenic hypertension as a result of bilateral renal affection.
Mazo
E B
EB
Kakitelashvili
V Ia
VIa
Darenkov
S P
SP
Drozhzheva
V V
VV
Masenko
V P
VP
Volkov
V N
VN
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000097:blood* / Q000378:metabolism; D012083:Renin / Q000097:blood / Q000378:metabolism
D011453:Prostaglandins; D002216:Captopril; D012083:Renin
Diagnosticheskoe znachenie opredeleniia prostaglandinov u bol'nykh nefrogennoĭ arterial'noĭ gipertenzieĭ.