Successful pregnancy following allogeneic bone marrow transplantation after conditioning by thoraco-abdominal irradiation.
A 26-year-old woman delivered a normal child 5 years after bone marrow transplantation for severe aplastic anemia. The conditioning regimen comprised high dose cyclophosphamide and thoraco-abdominal irradiation (6 Gy). This and two previous cases demonstrate that normal pregnancy can follow total body or thoracoabdominal irradiation.
Calmard-Oriol
P
P
Département d'Hématologie, Hôpital Nord, St Priest en Jarez, France.
Dauriac
C
C
Vu Van
H
H
Lacroze
M
M
Landriot
B
B
Guyotat
D
D
D000005:Abdomen / Q000528:radiation effects*; D000328:Adult; D000741:Anemia, Aplastic / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000187:drug effects / Q000528:radiation effects*; D011256:Pregnancy Outcome; D013909:Thorax / Q000528:radiation effects*; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation
D003520:Cyclophosphamide