title: Family history and brain morphology in schizophrenia: an MRI study.
abstract: This study examined neuroanatomical differences between male schizophrenic patients with a family history of psychosis (n = 16) and those without such a history (n = 15). Intracranial area, cerebral area, ventricular size, and cortical atrophy were assessed using magnetic resonance imaging (MRI). Third ventricular enlargement was more prevalent in patients than controls (n = 15). Familial and nonfamilial patients differed significantly. Reduced cranial and cerebral areas without ventricular enlargement characterized familial patients, whereas nonfamilial patients showed marked lateral ventricular enlargement without a reduction in cranial/cerebral size.
authors.affiliation: Department of Psychiatry, Ohio State University College of Medicine, Columbus 43210-1228.
authors.forename: S B
authors.initials: SB
authors.lastname: Schwarzkopf
authors.forename: H A
authors.initials: HA
authors.lastname: Nasrallah
authors.forename: S C
authors.initials: SC
authors.lastname: Olson
authors.forename: B
authors.initials: B
authors.lastname: Bogerts
authors.forename: J A
authors.initials: JA
authors.lastname: McLaughlin
authors.forename: T
authors.initials: T
authors.lastname: Mitra
mesh_terms: D000293:Adolescent; D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D012565:Schizophrenic Psychology