Further insight into the stereoselective interaction between warfarin and cimetidine in man.
The urinary profile of R- and S-warfarin, following administration of a single (25 mg) oral dose of racemic warfarin, alone or on day 4 of a 9-day chronic administration of cimetidine (800 mg once daily), was investigated in eight healthy male volunteers. Based on estimated apparent formation clearance values, cimetidine inhibited significantly only the formation of R-6-hydroxywarfarin and R-7-hydroxywarfarin.
Niopas
I
I
Department of Pharmacy, Aristotle University of Thessaloniki, Greece.
Toon
S
S
Rowland
M
M
D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D006900:Hydroxylation; D008297:Male; D013237:Stereoisomerism; D014859:Warfarin / Q000378:metabolism*
D014859:Warfarin; D002927:Cimetidine