[Experimental model for metastasis of cecal origin].
The pre-selected tumor cells injection in the cecal wall of rat, seems to be a intermediate model between spontaneous evolution of a colon tumor and intrasplenic or direct intraportal injections. From rhabdomyosarcoma cells (RMS S4-MH-) which present the advantage to prudce up lymphatic, pulmonary and hepatic metastases after subcutaneously injection, first subcutaneously (S.C.), intrasplenic (I.S.) and intracecal sites were compared: In the I.C. model, tumor was obtained in 80% of case and the survival was nearly similar to S.C. model's one. The lymphatic metastases were more and more distal as the evolution and the liver metastases were rarely observed. The I.S. model increased quickly and there were always liver metastases; In the two cases, pulmonary metastases were rarely observed (0 and 2/5). With adenocarcinoma colonic cells (Pro b) I.C. injection in the rat, tumor were obtained in 48% of cases without peritoneal dissemination; lymphatic nodes metastases were observed in 80% of cases; liver metastases was obtained in one animal from metastasis pulmonary selection cell lines. The I.C. model allows to estimate the liver and lymphatic nodes part; improved, it would be used to test adjuvant therapies and immunoscintigraphy.
Bail
J P
JP
Laboratoire de Microchirurgie Expérimentale, Faculté de Médecine, Brest.
Loridon
B
B
Aillet
G
G
Poupon
M F
MF
Douillard
J Y
JY
D000818:Animals; D002430:Cecal Neoplasms / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D007267:Injections / Q000379:methods; D007279:Injections, Subcutaneous; D008722:Methods; D009362:Neoplasm Metastasis / Q000473:pathology*; D009374:Neoplasms, Experimental / Q000473:pathology; D051381:Rats; D012208:Rhabdomyosarcoma / Q000473:pathology*
Modèle expérimental de métastases à point de départ caecal.