title: Serum macro creatine kinase type 2 as a tumor marker in lung cancer: comparison with carcinoembryonic antigen.
abstract: Macro creatine kinase type 2 (MCK-2), an atypical cathodically migrating creatine kinase isoenzyme, was first detected in the serum of a breast cancer patient in 1978. In recent years, MCK-2 was also found in the sera of several malignancies and has been proposed as a potential tumor marker. Forty two patients with lung cancer. The rates of MCK-2 presence in serum were 56.8%, 29.6%, and 0%, respectively, for primary lung cancer, inflammatory lung disease and normal controls. In primary lung cancer, the rate of presence of MCK-2 was higher than CEA (40.0%), and appeared more frequently in epidermoid cancer (71.3%) and in stages 3 and 4 (65.4%). Serial examinations postoperatively showed that MCK-2 became negative after resection. Carcinoembryonic antigen, MCK-2 or a combination of both was evaluated as a diagnostic aid in 37 patients with a peripheral pulmonary nodule. Sensitivity, specificity and accuracy were 32.0%, 90.9%, 50.0%, 36.4%, 93.3%, 59.5%; 43.8%, 90.5%, 70.3%, respectively, for CEA, MCK-2, and CEA plus MCK-2. It is concluded that MCK-2 is comparable to CEA as a tumor marker in lung cancer. The combination of MCK-2 and CEA is of value as a diagnostic aid in patients with a peripheral pulmonary nodule.
authors.affiliation: Department of Surgery, College of Medicine, National Taiwan University, Taipei, R.O.C.
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
authors.forename: K J
authors.initials: KJ
authors.lastname: Chang
authors.forename: F J
authors.initials: FJ
authors.lastname: Lu
authors.forename: P C
authors.initials: PC
authors.lastname: Yang
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007527:Isoenzymes; D008175:Lung Neoplasms / Q000175:diagnosis*; D011237:Predictive Value of Tests; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D007527:Isoenzymes; D003402:Creatine Kinase