title: [The evaluation of the reactogenicity and immunological activity of an inactivated 3-component influenza vaccine with an elevated hemagglutinin concentration in the inoculation dosage].
abstract: In this work the reactogenic properties and antigenic potency of inactivated trivalent influenza vaccine, obtained by elution and centrifugation and containing up to 9-11 micrograms of hemagglutinin for influenza viruses A(H1N1) and A(H3N2) and up to 14 micrograms for influenza virus B, were studied. The reactogenicity of the preparation was found to correspond to the regulations. The immunogenic potency characteristics of individual batches of this trivaccine were higher than the immunogenicity of divaccines, but did not meet the requirements of technical specifications.
authors.forename: I G
authors.initials: IG
authors.lastname: Marinich
authors.forename: A S
authors.initials: AS
authors.lastname: Shadrin
authors.forename: A N
authors.initials: AN
authors.lastname: Naĭkhin
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Ivannikov
authors.forename: N P
authors.initials: NP
authors.lastname: Kuznetsov
authors.forename: V I
authors.initials: VI
authors.lastname: Karogodina
authors.forename: A M
authors.initials: AM
authors.lastname: Shcherbinskaia
authors.forename: E G
authors.initials: EG
authors.lastname: Voronina
authors.forename: L D
authors.initials: LD
authors.lastname: Stepankovskaia
authors.forename: I V
authors.initials: IV
authors.lastname: Eliseeva
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D004306:Dose-Response Relationship, Immunologic; D004341:Drug Evaluation; D006389:Hemagglutinins, Viral / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D013997:Time Factors; D014586:USSR; D014505:Urban Population; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D006389:Hemagglutinins, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated
vernacular_title: Otsenka reaktogennosti i immunologicheskoĭ aktivnosti inaktivirovannoĭ trekhkomponentnoĭ grippoznoĭ vaktsiny s povyshennoĭ kontsentratsieĭ gemaggliutinina v privivochnoĭ doze.