Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes.
Apomorphine (Apo), a D1/D2 Dopamine (DA) agonist, at high doses (500 micrograms/kg) induces a short-lasting insomnia, antagonized by a secondary injection of corticotropin-like intermediate lobe peptide (CLIP, 10 ng); these effects are also observed with hypophysectomized (hypoX) rats. The administration of the serotonin (5-HT) agonist 8-hydroxy-2-di-n-propylamino-tetralin (8-OHDPAT, 0.3 mg/kg) induces also an insomnia which, unlike Apo, is followed by a significant PS rebound. CLIP, again, antagonizes the 8-OHDPAT-induced insomnia. Finally, Bromocriptine (5 mg/kg), an agonist for both DA and 5-HT, induces first an insomnia (antagonized by CLIP), followed by a PS rebound; these effects persist in hypoX rats.
Chastrette
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Department of Experimental Medicine, INSERM U52, CNRS UA1195 Claude Bernard University, Lyon, France.
Cespuglio
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Lin
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Jouvet
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D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000633:toxicity; D001971:Bromocriptine / Q000494:pharmacology; D053497:Corticotropin-Like Intermediate Lobe Peptide; D004298:Dopamine / Q000502:physiology; D018492:Dopamine Antagonists; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011333:Pro-Opiomelanocortin / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D012890:Sleep / Q000187:drug effects*; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced; D012894:Sleep Stages / Q000187:drug effects; D013764:Tetrahydronaphthalenes / Q000494:pharmacology; D000521:alpha-MSH / Q000031:analogs & derivatives / Q000494:pharmacology
D018492:Dopamine Antagonists; D010446:Peptide Fragments; D011954:Receptors, Dopamine; D013764:Tetrahydronaphthalenes; D012701:Serotonin; D001971:Bromocriptine; D053497:Corticotropin-Like Intermediate Lobe Peptide; D000521:alpha-MSH; D011333:Pro-Opiomelanocortin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000324:Adrenocorticotropic Hormone; D001058:Apomorphine; D004298:Dopamine