Effect of chlorpromazine on proline absorption across rat jejunum.
The effect of chlorpromazine on proline absorption across jejunum in anaesthetized rats was investigated. Intravenous infusion of chlorpromazine reduced significantly (P less than 0.01) proline absorption across the jejunum. Intraluminal perfusion of chlorpromazine into the jejunal segment reversed net absorption of proline to net secretion. Net water absorption was increased significantly (P less than 0.01) when chlorpromazine was infused intravenously or perfused intraluminally. Unidirectional influx of proline across the mucosal surface was significantly inhibited (P less than 0.01) after preincubation with 1 mM chlorpromazine.
Nassar
C F
CF
Department of Physiology, Faculty of Medicine, American University of Beirut, Lebanon.
Abdallah
L E
LE
Karkaji
E G
EG
D000818:Animals; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011392:Proline / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D011392:Proline; D002746:Chlorpromazine