Role of dopamine D-1 and D-2 receptors in the ventral striatum in the turning behaviour of rats.
Systemically administered methamphetamine and apomorphine evoked characteristic turning when rats were pretreated with injections of D-1 and D-2 antagonists in the ventral but not in the dorsal striatum. The frequency of turning was greater for rats pretreated with D-2 antagonists (l-sulpiride and YM-09151-2) than for rats pretreated with a D-1 antagonist (SCH 23390). The responses were apparently additive when rats were pretreated with mixed D-1/D-2 antagonists, (cis(Z)-flupentixol and SCH 23390 + l-sulpiride). These results suggest that dopamine D-1 and D-2 receptors in the ventral striatum mediate turning behaviour through separate but cooperative mechanisms.
Koshikawa
N
N
Department of Pharmacology, Nihon University School of Dentistry, Tokyo, Japan.
Mori
E
E
Maruyama
Y
Y
Yatsushige
N
N
Kobayashi
M
M
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001549:Benzamides / Q000494:pharmacology; D001552:Benzazepines / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism / Q000502:physiology*; D015259:Dopamine Agents / Q000494:pharmacology; D018492:Dopamine Antagonists; D005475:Flupenthixol / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*; D013239:Stereotyped Behavior / Q000502:physiology*; D013469:Sulpiride / Q000494:pharmacology
D001549:Benzamides; D001552:Benzazepines; D015259:Dopamine Agents; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D008694:Methamphetamine; D013469:Sulpiride; D005475:Flupenthixol; D001058:Apomorphine; C030265:nemonapride