Duodenal alkalinization releases secretin and vasoactive intestinal polypeptide and stimulates exocrine pancreatic secretion in the anesthetized rat.
The effect of various intraduodenal alkaline solutions (0.1 M NaHCO3, 0.1 M Na2CO3 and 0.025 M NaOH) on exocrine pancreatic secretion and the release of two peptides, secretin and vasoactive intestinal polypeptide, was studied in anesthetized rats. The flow rate of the pancreatic juice was stimulated up to a maximum of 179, 158 and 180% and the protein output up to 181, 131 and 162% (compared with basal) after duodenal perfusion of, respectively, 0.1 M NaHCO3, 0.1 M Na2CO3 and 0.025 M NaOH. Maximum increases in portal plasma secretin concentrations of 143, 146 and 190% and maximum increases in VIP of 116, 155 and 147% after, respectively, intraduodenal 0.1 M NaHCO3, 0.1 M Na2CO3, and 0.025 M NaOH were found. In conclusion duodenal alkalinization in the rat produces a pancreatic exocrine secretory response that may be partially ascribed to the effect of secretin and VIP.
García
L J
LJ
Department of Physiology and Pharmacology, Faculty of Biology, University of Salamanca, Spain.
Minguela
A
A
Montero
A
A
Calvo
J J
JJ
López
M A
MA
D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D002254:Carbonates / Q000494:pharmacology; D004386:Duodenum / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012633:Secretin / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology; D017693:Sodium Bicarbonate; D012972:Sodium Hydroxide / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D001639:Bicarbonates; D002254:Carbonates; D012633:Secretin; D014660:Vasoactive Intestinal Peptide; C005686:sodium carbonate; D012972:Sodium Hydroxide; D017693:Sodium Bicarbonate; D012964:Sodium