Haemodynamics in postural hypotension--effects of the beta-adrenoceptor partial agonist xamoterol, and pindolol.
Beta-andrenoceptor agents have been used in the treatment of postural hypotension and agonist activity found to be important. The effects of xamoterol and pindolol on standing haemodynamics were compared in this study. Xamoterol was found to be of significant benefit, but pindolol was ineffective. Xamoterol may therefore be useful in the treatment of postural hypotension.
Mehlsen
J
J
Department of Clinical Physiology, Frederikberg Hospital, Denmark.
Trap-Jensen
J
J
D000318:Adrenergic beta-Agonists / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy* / Q000503:physiopathology; D010869:Pindolol / Q000494:pharmacology* / Q000627:therapeutic use; D011412:Propanolamines / Q000494:pharmacology* / Q000627:therapeutic use; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D017307:Xamoterol
D000318:Adrenergic beta-Agonists; D011412:Propanolamines; D017307:Xamoterol; D010869:Pindolol