title: [Laurence-Moon-Biedl syndrome associated with tertiary hypothyroidism. A case report].
abstract: The Laurence-Moon-Biedl syndrome is characterized by retinitis pigmentosa, obesity, psychic disturbances, polydactily and hypogonadism. Renal involvement is also a frequent finding and renal failure may be fatal for the patient. On the basis of the consanguinity and the familiarity of this syndrome. R.C., a 47 years old male, with cardiovascular failure and marked psychic sleepiness has been studied. The patient showed the full picture of this syndrome. The thyroid function has been studied and, TT4, TBG, rT3, TSH, TRH stimulation test, antimicrosomial antitireoglobulin antibodies were found within normal limit. On the other hand TT3, FT3, FT4 and 131-I thyroid captation showed a clear hypothyroidism picture. In this connection, on L-T4 administration, infect there was a complete recovery of the symptoms. This picture may confirm the hypothesis of a hypothalamic disfunction in the Laurence-Moon-Biedl syndrome.
authors.affiliation: Divisione di Medicina Generale, Ospedale Ninetto Melli, S. Pietro Vernotico, Brindisi.
authors.forename: Q
authors.initials: Q
authors.lastname: Capellini
authors.forename: G
authors.initials: G
authors.lastname: Barba
mesh_terms: D000328:Adult; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D007849:Laurence-Moon Syndrome / Q000150:complications*; D008297:Male
vernacular_title: La sindrome di Laurence-Moon-Biedl associata ad ipotiroidismo terziario. Un contributo casistico.