[Multifactorial study of the combined effect of rifampicin and microbial peptidoglycan in experimental plague infection].
The combined effect of rifampicin and a microbial peptidoglycan was studied in multifactorial experiments on noninbred mice with plague infection. The effect of rifampicin and the immunomodulator was shown to be synergistic. The results of the multifactorial experiments provided designing of polynomial statistic models of the second order characterizing the animal survival rate and mean life-span and plotting of nomograms or equal level lines useful in optimization of the combined therapy parameters.
Nikitin
A V
AV
Makarovskaia
L N
LN
Fomina
I P
IP
Ivanitskaia
L P
LP
Popova
G O
GO
Vinidchenko
N N
NN
Korganov
Ia N
IaN
Bodunkova
L E
LE
D000818:Animals; D000900:Anti-Bacterial Agents; D003627:Data Interpretation, Statistical; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D051379:Mice; D010457:Peptidoglycan / Q000627:therapeutic use*; D010930:Plague / Q000188:drug therapy*; D012231:Rhizobium; D012293:Rifampin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D010457:Peptidoglycan; D012293:Rifampin
Mnogofaktornoe izuchenie kombinirovannogo deĭstviia rifampitsina i peptidoglikana mikrobnogo proiskhozhdeniia pri éksperimental'noĭ chumnoĭ infektsii.