title: Type II estrogen binding sites (EBS) in intracranial tumors.
abstract: Four meningiomas and six neuroepithelial tumors were assayed for the presence of estrogen receptors (ER), type II estrogen binding sites (EBS) and progesterone receptors (PgR). ER were detected in 7 out of 10 cases with levels ranging between 2.5 and 20.7 fmoles/mg of cytosolic protein. On the contrary, PgR were found in all samples (10 cases) and their levels ranged between 8.8 and 130.6 fmoles/mg of cytosolic protein. All tumor samples expressed appreciable amounts of type II EBS ranging between 452 and 2320 fmoles/mg of protein. Although the precise functional role of type II EBS is still unknown, their presence may reflect an hormonal sensitivity of these tumors.
authors.affiliation: Istituti di Anatomia Patologica, Università Cattolica del S. Cuore, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Capelli
authors.forename: M
authors.initials: M
authors.lastname: Piantelli
authors.forename: A
authors.initials: A
authors.lastname: Rinelli
authors.forename: E
authors.initials: E
authors.lastname: Macri
authors.forename: R
authors.initials: R
authors.lastname: Ricci
authors.forename: L M
authors.initials: LM
authors.lastname: Larocca
authors.forename: M
authors.initials: M
authors.lastname: Scerrati
authors.forename: R
authors.initials: R
authors.lastname: Roselli
authors.forename: M
authors.initials: M
authors.lastname: Iacoangeli
authors.forename: F O
authors.initials: FO
authors.lastname: Ranelletti
mesh_terms: D001932:Brain Neoplasms / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D009380:Neoplasms, Nerve Tissue / Q000737:chemistry*; D011960:Receptors, Estrogen / Q000032:analysis* / Q000145:classification; D011980:Receptors, Progesterone / Q000032:analysis
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone