[Effects of phencyclidine analogs and phencyclidine/sigma ligands on vasoconstrictor response of rat mesenteric arteries induced by electrical field stimulation].
Using the model of perfused mesenteric arteries of rat, we studied the effect of phencyclidine (PCP), N-[1-(2-thienyl)cyclohexyl] piperidine (TCP), N,N-dimethylphenylcyclohexylamine (PCDA), N-(iso-propyl)-1-phenylcyclohexylamine (PCIPA), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801), (+),(-)-N-allylnormetazocine (SKF 10 047), dextrorphan, and levorphanol on vasoconstrictor response induced by electrical field stimulation. PCP, TCP, PCDA, PCIPA, MK-801, levorphanol, and (-)-SKF 10 047 were found to increase the vasoconstrictor response in dose-dependent manner. The dose-effect curves of these compounds were similar to the curve of PCP. Although dextrorphan, an antagonist for PCP receptors, did not affect the vasoconstrictor response, it could non-competitively antagonize PCP's action. These studies suggest that some PCP analogs and PCP/sigma ligands may enhance the vasoconstrictor response induced by electrical field stimulation via action on PCP receptors.
Lu
Y F
YF
Department of Neurobiology, Shanghai Medical University, China.
Sun
F Y
FY
Zhang
A Z
AZ
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000502:physiology; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D017478:Receptors, Phencyclidine; D014661:Vasoconstriction / Q000187:drug effects*
D017981:Receptors, Neurotransmitter; D017478:Receptors, Phencyclidine; D010622:Phencyclidine