title: c-fos protein like immunoreactivity in non-neuronal cells of rat peripheral nerve after transection.
abstract: The induction of c-fos protein (Fos) in non-neuronal cells of rat sciatic nerve was studied immunocytochemically after transection. As soon as 1 h after transection a few Fos-positive Schwann cells and fibroblast-like cells were seen around the wound margins. In the epi-perineurial fibroblast-like cells Fos-like immunoreactivity (Fos-LI) was most intense at 3 h postoperation, but no Fos-LI was seen at 6 days postoperation. In Schwann cells Fos-LI was spread throughout the distal nerve segment at 6 days postoperation, when the staining (in these cells) was most intense. Fos-immunoreactive Schwann cells in the distal nerve segment were still detectable at 14 days postoperation. In the proximal nerve segment positively labelled Schwann cells were observed only 1 and 3 h postoperation and were localized near the site of injury. The results show that the loss of nerve fibers induces a long-lasting expression of Fos or Fos-related antigens in a peripheral nerve.
authors.affiliation: Department of Public Health, University of Tampere, Finland.
authors.forename: I
authors.initials: I
authors.lastname: Pyykönen
authors.forename: J
authors.initials: J
authors.lastname: Koistinaho
mesh_terms: D000818:Animals; D005347:Fibroblasts / Q000166:cytology; D007124:Immunoenzyme Techniques; D007700:Kinetics; D008297:Male; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012583:Schwann Cells / Q000166:cytology; D012584:Sciatic Nerve / Q000166:cytology / Q000502:physiology*; D013997:Time Factors
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D011505:Protein-Tyrosine Kinases