Dideoxycytidine toxicity on mouse hemopoietic progenitors.
Several antiviral compounds showed a toxicity or hemopoietic progenitor cells, 2', 3' Dideoxycytidine (ddc) is the most potent drug in vitro against human T cell lymphotropic viruses and is now being tested on patients with AIDS and AIDS-related complex. We studied its toxicity on mouse hemopoietic progenitors. Results reported here show a toxic activity of ddc but further studies are required to ascertain whether this toxicity is of significance during clinical application.
Mencoboni
M
M
Istituto Scientifico di Medicina Interna, Università di Genova, Italy.
Lerza
R
R
Bogliolo
G
G
Flego
G
G
Gasparini
L
L
Pannacciulli
I
I
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D003114:Colony-Forming Units Assay; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D010198:Pancytopenia / Q000139:chemically induced*; D016047:Zalcitabine / Q000494:pharmacology / Q000633:toxicity*
D016047:Zalcitabine