Modulating effects of antiasthmatic and antitussive drugs on autonomic neurotransmission in guinea-pig bronchial muscle in vitro.
Electrical field stimulation evoked a biphasic contraction of the guinea-pig isolated bronchi, consisting of a cholinergically mediated fast contraction followed by a non-cholinergically mediated slow contraction. Catecholamines, beta 2-stimulants, methylxanthines, antiallergic drugs, narcotic and non-narcotic antitussive drugs inhibited the neurogenic contractions not only by postjunctional depression of the response but also by prejunctional reduction of the transmitter release.
Kamikawa
Y
Y
Department of Pharmacology, Dokkyo University School of Medicine, Tochigi, Japan.
Shimo
Y
Y
D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy*; D001341:Autonomic Nervous System / Q000187:drug effects*; D001980:Bronchi / Q000294:innervation*; D016084:Bronchoconstriction / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology; D004558:Electric Stimulation; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000188:drug therapy; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects*
D000996:Antitussive Agents; D002395:Catecholamines; D013566:Sympathomimetics