Renal excretion of creatinine, electrolytes, protein, and enzymes in healthy sheep.
Urinary indices of renal function and damage were measured in 6 healthy, mature ewes over a 48-hour period. Endogenous creatinine clearance, total and fractional electrolyte excretion rates, protein excretion, urine volume, and urine gamma-glutamyltransferase and beta-glucuronidase activities were measured. Significant variations in the excretion rates of creatinine, electrolytes, and protein were not found between intervals within the 48-hour urine collection period. Total urinary electrolyte excretion rates were significantly (P less than 0.001) correlated with fractional electrolyte excretion rates normalized for creatinine concentration; however, coefficient of determination was low.
Garry
F
F
Department of Veterinary Clinical Sciences, Ohio State University, Columbus 43210.
Chew
D J
DJ
Rings
D M
DM
Tarr
M J
MJ
Hoffsis
G F
GF
D000818:Animals; D003404:Creatinine / Q000097:blood / Q000652:urine*; D004573:Electrolytes / Q000097:blood / Q000652:urine*; D005260:Female; D005966:Glucuronidase / Q000097:blood / Q000652:urine*; D011507:Proteinuria / Q000097:blood / Q000662:veterinary*; D012756:Sheep / Q000097:blood / Q000652:urine*; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000652:urine*
D004573:Electrolytes; D003404:Creatinine; D005723:gamma-Glutamyltransferase; D005966:Glucuronidase