Methyl N-(diphenylmethyl)-D,L-tryptophanates: synthesis and benzodiazepine receptor affinity.
Several Methyl N-(diphenylmethyl)-D,L-tryptophanates were synthetized and the affinity for the central benzodiazepine receptor was measured. Disappointingly, none of the tested compounds showed to be active, even at the high concentration examined.
Balsamini
C
C
Istituto di Chimica Farmaceutica, Università di Urbino, Italy.
Duranti
E
E
Salvatori
A
A
Spadoni
G
G
Barone
D
D
D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003975:Diazepam / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*
D011963:Receptors, GABA-A; D001569:Benzodiazepines; D003975:Diazepam