[Studies on the determination of the circulating antigen in experimental toxoplasmosis].
This paper reports on the regular pattern of growth and decline of the circulating antigen (CA) determined by I-ELISA in experimentally infected rabbits. Toxoplasma antigen was demonstratable in the circulation in 64.7% rabbits 1 day after tachyzoite inoculation and the level of the CA in sera from infected rabbits showed an increase on d4 and reached its peak level on d10-13 after inoculation but declined soon thereafter. CA was not detectable on days 60 to 90 after inoculation. The results suggest that determining CA is a useful means for diagnosing active toxoplasmosis and that I-ELISA might be a promising approach to detect CA in toxoplasmosis.
Guo
X H
XH
Department of Parasitology, Sun Yat-Sen University of Medical Sciences, Guangzhou.
Chen
G J
GJ
Hsu
P K
PK
Liu
D H
DH
Zheng
H Q
HQ
D000818:Animals; D000953:Antigens, Protozoan / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D011817:Rabbits; D013997:Time Factors; D014122:Toxoplasma / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000276:immunology*
D000953:Antigens, Protozoan