Kidney damage in rats bearing an adrenocorticotropin and prolactin secreting tumor.
The effect of chronic high plasma corticosteroids' concentration upon renal function was studied in rats bearing a transplantable pituitary mammotropic tumor which produces large quantities of ACTH and prolactin (MtTF4S). Kidney splanchnomegaly and degenerative changes of renal cortex, particularly in proximal tubules, as well as cytolysis and appearance of vacuoles were noticed in tumor bearing rats. (Na+ + K+)-ATPase activity in renal plasma membranes decreased 67% in rats with a tumor secreting ACTH and prolactin, and 64% in rats with a tumor secreting growth hormone and prolactin when compared with controls. After adrenalectomy of MtTF4S rats, kidney weight as well as plasma concentrations of urea, sodium, chloride and phosphate ions were normalized indicating the involvement of adrenal glands in the development of disturbances in renal function.
Dobrović-Jenik
D
D
Laboratory of Pharmacology, Pharmacy and Biochemistry, University of Zagreb, Yugoslavia.
Dusanek
S
S
Milković
S
S
D000311:Adrenal Glands / Q000378:metabolism / Q000503:physiopathology; D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D007672:Kidney Cortex / Q000201:enzymology / Q000473:pathology*; D009929:Organ Size; D009384:Paraneoplastic Endocrine Syndromes; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase