title: In vivo stereological assessment of human cerebellar volume: effects of gender and age.
abstract: Intermediate T2-weighted MR images and a systematic sampling stereological method were used in 37 normal volunteers, 24 to 79 years old, to assess the effects of age and sex on cerebellar volume. Female subjects (n = 21) had significantly smaller cerebellar volumes compared with males (n = 16) of similar age (t = -3.9, p less than .0008, two-tail t test). Using straight-line, univariate regression, we determined that age was not a significant predictor of cerebellar volume (R2 = 0.07, t = -1.66, p = 0.11), whereas gender did appear to account for a significant amount of variability in cerebellar volume (R2 = 0.33, t = -4.13, p = .0002). The mean absolute cerebellar volume in this study was 112 ml (SD +/- 16) for all subjects, 104 ml (SD +/- 10) for females, and 122 ml (SD +/- 16) for males. This study demonstrates the feasibility of using MR images along with a systematic stereological method to assess in vivo human cerebellar volume, thereby providing a research tool to correlate cerebellar morphology with cognitive and neuromotor function.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
authors.forename: P R
authors.initials: PR
authors.lastname: Escalona
authors.forename: W M
authors.initials: WM
authors.lastname: McDonald
authors.forename: P M
authors.initials: PM
authors.lastname: Doraiswamy
authors.forename: O B
authors.initials: OB
authors.lastname: Boyko
authors.forename: M M
authors.initials: MM
authors.lastname: Husain
authors.forename: G S
authors.initials: GS
authors.lastname: Figiel
authors.forename: D
authors.initials: D
authors.lastname: Laskowitz
authors.forename: E H
authors.initials: EH
authors.lastname: Ellinwood
authors.forename: K R
authors.initials: KR
authors.lastname: Krishnan
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D002531:Cerebellum / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012727:Sex Characteristics