title: [Granulocyte beta-adrenoceptor density increased with methylprednisolone in patients receiving dopamine infusion].
abstract: Methylprednisolone (MP) is frequently used in shock states, its antishock mechanisms, however, have not been clarified. Effect of MP 10 mg.kg-1 on granulocyte beta-adrenoceptor density was studied in two patients who required dopamine infusion postoperatively. The granulocyte beta-adrenoceptor density was calculated from the binding of [3H] dihydroalprenolol. Arterial blood pressure and cardiac output increased 1 hr after MP administrations. Beta-adrenoceptor densities were low in both cases prior to the administration of MP (16.1 and 24.6 fmol.mg-1 protein), which increased 11 hr after MP (31.2 and 35.8 fmol.mg-1 protein, respectively). The effects of MP to improve status of cardiovascular system in patients receiving catecholamine-infusion may be associated with the increase in the density of myocardial "down-regulated" beta-adrenoceptor.
authors.affiliation: Department of Anesthesia, Kyoto University Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
authors.forename: K
authors.initials: K
authors.lastname: Shingu
authors.forename: T
authors.initials: T
authors.lastname: Magaribuchi
authors.forename: S
authors.initials: S
authors.lastname: Nakao
authors.forename: S
authors.initials: S
authors.lastname: Tamai
authors.forename: K
authors.initials: K
authors.lastname: Shindo
authors.forename: K
authors.initials: K
authors.lastname: Mori
mesh_terms: D004298:Dopamine / Q000008:administration & dosage*; D005260:Female; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
chemical_list: D011943:Receptors, Adrenergic, beta; D004298:Dopamine; D008775:Methylprednisolone