[Antiviral activity of commercial immunoglobulin preparations].
Immunoglobulin preparations for intravenous use of five different firms--Biotest, Hoechst, Merieux, Sandoz, WWSS--were used for the study. Antibody level for Epstein-Barr, cytomegalia, herpes simplex, varicella-zoster and measles viruses was determined in these preparations stored at 4 degrees C and in order to determine their stability they were tested after incubation at 37 degrees C and 61 degrees C. The influence of immunoglobulin (Bioglobulin and Sandoglobulin) on mouse survival infected with HSV-1 was determined. Results of serological studies revealed differentiated antibody level for particular virus antigens both in various series of a given preparation as well as between immunoglobulins of different producers. Protective activity of immunoglobulin was mainly found when given 24 hours before challenge with HSV-1. This was the case not only when preparations stored at 4 degrees C were given but also for those which were incubated at 37 degrees C for months. Forty percent higher rate of survival of mice as compared to control group was seen when immunoglobulin were given 8 hours after infection.
Litwińska
B
B
Zakład Wirusologii PZH w Warszawie.
Bucholc
B
B
Sadowski
W
W
Kańtoch
M
M
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D004195:Disease Models, Animal; D005060:Europe; D006564:Herpesviridae / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000276:immunology*; D066298:In Vitro Techniques; D008457:Measles / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D008459:Measles virus / Q000276:immunology*; D051379:Mice
D000914:Antibodies, Viral; D007136:Immunoglobulins
Przeciwwirusowa aktywność handlowych preparatów immunoglobulin.