Effect of dibutyrylo cyclic AMP on Golgi complex activity in the intestinal epithelial cells of salivectomised mice.
Effects of dibutyryl cyclic AMP on enzymatic reaction for the thiamine pyrophosphatase, NADPH-tetrazolum, reductase, adenosine--triphosphatas -Ca-formol and acid phosphatase were investigated in the intestinal epithelium of the salivectomised mice. After intraperitoneal injections of dibutyryl cyclic AMP a marked increase of enzymatic reaction for thiamine pyrophosphatase (a marker of the Golgi complex) was noted, especially after 4 injections of dibutyryl cyclic AMP (twenty four hours after first injection). At the same time the intensities of reaction for the NADPH-r.t., ATP-ase-Ca-Formol and AcP did not undergo any changes in epithelial cells of intestinal villi after salivectomy and after dibutyrylo cyclic AMP administration. The obtained results suggest that dibutyrylo cyclic AMP probably regulates the Golgi complex activity.
Dyduch
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Silesian Pediatric Center, Silesian School of Medicine, Zabrze, Poland.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000187:drug effects / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D013363:Submandibular Gland / Q000502:physiology* / Q000601:surgery; D013834:Thiamine Pyrophosphatase / Q000378:metabolism
D003994:Bucladesine; D013834:Thiamine Pyrophosphatase