[Obesity and adipose tissue distribution in men: relation to sex steroids and insulin].
The aim of this study was to assess the correlation between the distribution of adipose tissue, sexual hormones and hyperinsulinemia in male obesity. Fifty-two obese males, aged 40.0 +/- 10.9 years old and with a body mass index (BMI) of 35.0 +/- 6.1 (m +/- SD), not suffering from diabetes or any other endocrine disease, were included in the study. A group of 20 subjects aged 30.5 +/- 7.9 (p less than 0.005 vs obese subjects) and with a BMI of 23.0 +/- 2.0 were used as controls. Body fat distribution was assessed using the waist/hip ratio (w/h ratio): 0.985 +/- 0.052 in obese subjects and 0.913 +/- 0.061 in controls (p less than 0.005). In comparison to control subjects, significantly lower levels of total (T) (357 +/- 132 vs 498 +/- 142 ng/dl; p less than 0.005) and free testosterone (FT) (14.2 +/- 2.9 vs 17.1 +/- 2.6 pg/ml; p less than 0.05) were found in the obese group, as well sex hormone binding globulin (SHBG) (41.7 +/- 31.9 vs 66.2 +/- 18.6 nmol/l; p less than 0.001). None of the other steroids (androstenedione, dehydroepiandrosterone-sulphate, estrone, 17 beta-estradiol, dihydrotestosterone) or FSH and LH gonadotropins assayed differed between the two groups. Significantly higher levels of insulin and C-peptide, both fasting and after a oral glucose tolerance test, were also found in obese subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
Casimirri
F
F
Ospedale S. Orsola, Università Alma Mater di Bologna.
Pasquali
R
R
Cantobelli
S
S
Melchionda
N
N
Barbara
L
L
D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D000728:Androgens / Q000097:blood; D015992:Body Mass Index; D002096:C-Peptide / Q000032:analysis; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000473:pathology*; D010908:Pituitary Hormones, Anterior / Q000097:blood; D012727:Sex Characteristics; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone / Q000097:blood*
D000728:Androgens; D002096:C-Peptide; D007328:Insulin; D010908:Pituitary Hormones, Anterior; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone
Obesità e distribuzione del tessuto adiposo nell'uomo: relazione con gli steroidi sessuali e l'insulina.