title: The protective role of humoral neutralizing antibody in the NIH potency test for rabies vaccines.
abstract: Intraperitoneal vaccination of mice with rabies vaccine results in both dosage-dependent rabies virus neutralizing antibody titres and protection from lethal intracerebral (i.c.) challenge with fixed strain CVS rabies virus. Pre-exposure adoptive intravenous transfer of naive or immune cells did not significantly protect naive Balb/c mice from lethal i.c. CVS challenge, but immune serum and anti-rabies glycoprotein monoclonal antibodies (individually and in combination) did confer significant protection when administered before or up to 24 h after lethal i.c. rabies virus challenge.
authors.affiliation: Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta, GA 30333.
authors.forename: P S
authors.initials: PS
authors.lastname: Wunderli
authors.forename: J H
authors.initials: JH
authors.lastname: Shaddock
authors.forename: D S
authors.initials: DS
authors.lastname: Schmid
authors.forename: T J
authors.initials: TJ
authors.lastname: Miller
authors.forename: G M
authors.initials: GM
authors.lastname: Baer
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology*; D005260:Female; D016219:Immunotherapy, Adoptive; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D011819:Rabies Vaccines / Q000276:immunology*; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines