title: Factors modifying the tissue selectivity of calcium-antagonists.
abstract: The factors modifying the tissue selectivity of calcium-antagonists are reviewed, with special reference to smooth muscle. Nicardipine was the most selective compound for the vasculature compared with the myocardium.
authors.affiliation: Syntex Research Centre, Riccarton, Edinburgh, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Spedding
authors.forename: S
authors.initials: S
authors.lastname: Fraser
authors.forename: B
authors.initials: B
authors.lastname: Clarke
authors.forename: L
authors.initials: L
authors.lastname: Patmore
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics* / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D006321:Heart / Q000187:drug effects; D015394:Molecular Structure; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels