Regional cerebral blood flow in schizophrenia: repeated studies during a psychotic episode.
Regional cerebral blood flow (rCBF) measurements and clinical ratings were performed on 17 schizophrenic patients and a subgroup of 10 medication-free patients before and after treatment. While clinically exacerbated patients had normal blood flow, patients in remission showed a redistribution of flow with lower values in frontal areas. Anteroposterior ratios correlated with the degree of behavioral disturbances, suggesting that the level of frontal lobe activity in schizophrenia may be a function of the patient's clinical state at the time of study.
Warkentin
S
S
Department of Psychogeriatrics, CBF-Lab, St. Lars Hospital, Lund, Sweden.
Nilsson
A
A
Risberg
J
J
Karlson
S
S
Flekköy
K
K
Franzén
G
G
Gustafson
L
L
Rodriguez
G
G
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000188:drug therapy; D012563:Schizophrenia, Paranoid / Q000000981:diagnostic imaging; D012565:Schizophrenic Psychology; D014980:Xenon Radioisotopes
D014150:Antipsychotic Agents; D014980:Xenon Radioisotopes