The effects of secretin on prolactin, estradiol, vasoactive intestinal polypeptide, and somatostatin levels in women.
The effect of graded doses of intravenous secretin (0.5, 1.0, and 2.0 CU.kg-1.h-1) on serum prolactin and estradiol levels, as well as plasma vasoactive intestinal polypeptide and somatostatin levels was studied in 6 normally cycling and healthy women, and compared with the hormone levels obtained by a control infusion with physiologic saline (0.15 mol/l). A significant decrease in serum prolactin concentrations was found with increasing doses of secretin at steady-state levels of plasma secretin (+30 to +60 min). A significant negative correlation (p less than 0.007, r = -0.2764) existed between serum prolactin and plasma secretin concentrations at steady-state conditions. No effect of graded doses of secretin was observed on serum estradiol levels and plasma concentrations of vasoactive intestinal polypeptide and somatostatin. The results suggest a dose-related inhibitory effect of secretin on prolactin release in women.
Holst
N
N
Department of Obstetrics and Gynecology, University of Tromsø, Norway.
Jenssen
T G
TG
Burhol
P G
PG
Haug
E
E
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007700:Kinetics; D011388:Prolactin / Q000097:blood*; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology*; D013004:Somatostatin / Q000097:blood*; D014660:Vasoactive Intestinal Peptide / Q000097:blood*
D012633:Secretin; D014660:Vasoactive Intestinal Peptide; D004958:Estradiol; D013004:Somatostatin; D011388:Prolactin