Experimental allergic neuritis in the SJL/J mouse: dysfunction of peripheral nerve without clinical signs.
Experimental allergic neuritis (EAN) was studied in the SJL/J mouse and compared to EAN in the Lewis rat. The Lewis rat developed hind limb weakness and weight loss while the SJL/J mouse had no discernible clinical abnormalities. The SJL/J mouse, however, suffered subclinical damage to peripheral nerve (PN) myelin. Both species reproducibly developed electrophysiologic dysfunction of PN and histopathology confined to the peripheral nervous system (PNS). Understanding of autoimmune demyelination in the central nervous system was greatly enhanced by the development of experimental allergic encephalomyelitis in the SJL/J mouse. We believe that EAN in the SJL/J mouse could lead to a similar increase in our understanding of autoimmune demyelination in the PNS.
Dieperink
M E
ME
Department of Neurology, University of Chicago, IL 60637.
O'Neill
A
A
Maselli
R
R
Stefansson
K
K
D000200:Action Potentials; D000208:Acute Disease; D000818:Animals; D002417:Cattle; D002490:Central Nervous System / Q000473:pathology; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000502:physiology*; D009132:Muscles / Q000503:physiopathology; D009186:Myelin Sheath / Q000378:metabolism; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D011917:Rats, Inbred Lew; D014020:Tissue Extracts / Q000276:immunology
D014020:Tissue Extracts