title: Transient expression of somatostatin mRNA in the auditory system of neonatal rat.
abstract: Postnatal changes of preprosomatostatin mRNA expression in the rat auditory system were examined using in situ hybridization histochemical techniques. It was found that during postnatal days 1 and 2 most of the neurons in the dorsal and ventral cochlear nuclei, and large numbers of neurons in the inferior colliculus, paralemniscal nucleus, and lateral lemniscal nucleus, expressed somatostatin mRNA with a strong intensity. During postnatal development a marked decrease in the number and intensity of neurons expressing somatostatin mRNA was seen. These findings suggested that somatostatin was actively produced in the cochlear nuclei at a very early stage but that production later became reduced or ceased during postnatal ontogeny.
authors.affiliation: Department of Neuroanatomy, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sekitani
authors.forename: S
authors.initials: S
authors.lastname: Shiosaka
authors.forename: H
authors.initials: H
authors.lastname: Kuriyama
authors.forename: Y
authors.initials: Y
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: M
authors.initials: M
authors.lastname: Tohyama
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D001306:Auditory Pathways / Q000166:cytology / Q000378:metabolism*; D003056:Cochlear Nerve / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D005786:Gene Expression Regulation; D007245:Inferior Colliculi / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D011498:Protein Precursors / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012249:Rhombencephalon / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D013004:Somatostatin / Q000235:genetics / Q000378:metabolism*
chemical_list: D011498:Protein Precursors; D012333:RNA, Messenger; D013004:Somatostatin