title: Adrenergic cardiovascular actions in rats as affected by dichloromethane exposure.
abstract: Dichloromethane sensitizes the myocardium to arrhythmia development in response to catecholamines. The effects of acute dichloromethane exposure (3.1, 6.2 or 12.4 mmol/kg) on cardiovascular actions of epinephrine (1 or 4 micrograms/kg iv) and norepinephrine (2 or 10 micrograms/kg iv) in the urethane-anaesthetized rat model was investigated. Hypertensive epinephrine effects as well as reflex bradycardia after epinephrine and norepinephrine injections were augmented in dichloromethane-exposed rats. Moreover we observed an enhanced negative dromotropic epinephrine action. The transient T-wave elevation after catecholamine injection was markedly increased in animals treated with 12.4 mmol/kg dichloromethane. The results show that dichloromethane exposure modifies cardiovascular actions after catecholamine administration. The release by dichloromethane of endogenous catecholamines could play a role in the manifestation of these effects.
authors.affiliation: Institute of Industrial Toxicology, Martin Luther University, Halle, FRG.
authors.forename: S
authors.initials: S
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Weise
authors.forename: T
authors.initials: T
authors.lastname: Krug
authors.forename: P
authors.initials: P
authors.lastname: Hoffmann
mesh_terms: D000320:Adrenergic Fibers / Q000187:drug effects; D000758:Anesthesia; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002849:Chromatography, Gas; D004347:Drug Interactions; D004562:Electrocardiography; D004837:Epinephrine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008752:Methylene Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008752:Methylene Chloride; D009638:Norepinephrine; D004837:Epinephrine