Mutagen formation on nitrite treatment of indole compounds derived from indole-glucosinolate.
The mutagenicities of 8 indole compounds (indole-3-acetonitrile, indole-3-carbinol, indole-3-acetamide, indole-3-acetic acid, 3-methylindole, indole-3-aldehyde, indole-3-carboxylic acid and indole) derived from indole glucosinolate were studied by mutation tests on Salmonella typhimurium TA98 and TA100 and Escherichia coli WP2 uvrA/pKM101 with and without S9 mix. None of the 8 indole compounds were mutagenic, but they became mutagenic on these 3 tester strains when treated with nitrite at pH 3. The nitrite-treated indole compounds were mutagenic without metabolic activation system (S9 mix), and their mutagenicities were decreased by the addition of S9 mix.
Sasagawa
C
C
Department of Molecular Oncology, University of Tokyo, Japan.
Matsushima
T
T
D005961:Glucosinolates / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry / Q000633:toxicity*; D015394:Molecular Structure; D009152:Mutagenicity Tests; D009153:Mutagens / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D009573:Nitrites / Q000737:chemistry*
D005961:Glucosinolates; D007211:Indoles; D009153:Mutagens; D009573:Nitrites