Sleep changes induced by the local application of 5,7-dihydroxytryptamine into the nodose ganglia and aortic denervation in the rat.
The effects of a bilateral microinjection of 5,7-dihydroxytryptamine (5,7-DHT) into the nodose ganglia and aortic denervation on the daily amounts of sleep/wake states were studied in rats. Both lesions produced an increase in paradoxical sleep and provoked the onset of paradoxical sleep episodes without slow-wave-sleep transition ("narcolepsy-like" paradoxical sleep episodes). The increase in paradoxical sleep observed after 5,7-DHT injection was more important than that of the aortic denervation. In addition, both 5,7-DHT-treated and aortic-denervated animals exhibited a delayed decrease in slow-wave sleep associated with an increase in wakefulness. These results show that the peripheral messages coming from aortic serotonergic afferent fibres to the nucleus tractus solitarius play a modulatory role in the daily expression of paradoxical sleep in rats.
Orer
H S
HS
INSERM U288, Neurobiologie Cellulaire et Fonctionelle Faculté de Médicine Pitié-Salpêtrière, Paris, France.
Merahi
N
N
Nosjean
A
A
Gozlan
H
H
Laguzzi
R
R
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000294:innervation*; D001522:Behavior, Animal / Q000187:drug effects; D003714:Denervation; D008297:Male; D009424:Nervous System Physiological Phenomena; D009620:Nodose Ganglion / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D012894:Sleep Stages / Q000187:drug effects
D015116:5,7-Dihydroxytryptamine