Cerebral and renal arterial thromboses in systemic lupus erythematosus with antiphospholipid antibodies: a report of two cases.
Antiphospholipid antibodies have been associated with an increased risk of thromboses, most of which occur in veins. We observed a very unusual association of cerebral and renal thromboses, in 2 patients with systemic lupus and anti-prothrombinase, in whom arterial occlusions were clearly documented. Immunosuppressive treatment was followed by a dramatic improvement in both. In the literature, no treatment clearly prevents the recurrence of these thromboses. This could be partly explained by our current ignorance of their pathogeny.
Balligand
J L
JL
Service de Médecine Interne, Cliniques Universitaires St Luc, Bruxelles.
Lefèbvre
C
C
Zenagui
D
D
Coche
E
E
D000328:Adult; D001323:Autoantibodies / Q000302:isolation & purification; D001779:Blood Coagulation Factors / Q000302:isolation & purification; D002308:Cardiolipins / Q000276:immunology; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000175:diagnosis / Q000209:etiology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000175:diagnosis / Q000209:etiology*; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology*
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; C028128:antiprothrombinase