Release characteristics of a free polyunsaturated fatty acid from an oily lymphographic agent.
The release profiles of a free polyunsaturated fatty acid, alpha-linolenic acid, from solutions in an oily lymphographic agent Lipiodol-Ultra-Fluid (Lipiodol), to rabbit and human plasma, phosphate buffer solution (PBS), and PBS containing bovine serum albumin (BSA) were examined in vitro. The times required for 50% release of alpha-linolenic acid from Lipiodol were about 1 and 1.5 h in the rabbit and human plasma, respectively. Although only a slight amount of alpha-linolenic acid was released from Lipiodol to PBS after 24 h incubation at 37 degrees C, release was markedly enhanced by the addition of BSA to PBS. The amount of alpha-linolenic acid released from Lipiodol into PBS containing 5% BSA increased as the alpha-linolenic acid content in Lipiodol was increased. In all experiments, the release had stopped before all alpha-linolenic acid had been released. The prolongation of alpha-linolenic acid release from Lipiodol is considered a requisite for a selective anticancer effect of Lipiodol containing a free fatty acid on liver cancer.
Hayashi
Y
Y
Department of Pharmacy, Kumamoto University Hospital, Japan.
Fukushima
S
S
Kishimoto
S
S
Nakano
M
M
D000818:Animals; D002626:Chemistry, Pharmaceutical; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D007459:Iodized Oil / Q000737:chemistry*; D011817:Rabbits; D012709:Serum Albumin / Q000737:chemistry
D005231:Fatty Acids, Unsaturated; D012709:Serum Albumin; D007459:Iodized Oil