[The augmenting effect of selenium(Se) on cell-mediated immunity. III. Se enhances delayed-type hypersensitivity reaction by promoting antigen presentation].
Delayed-type hypersensitivity reaction (DTH) to TNCB in TNCB-primed mice was increased when mice was treated with sodium selenite. In vitro studies showed that primed T cells proliferated more vigorously when TNP-conjugated spleen adherent cells (SAC) from Se-treated mice were the stimulators as compared with SAC of untreated controls. TNP-conjugated SAC treated in vitro with sodium selenite were even stronger stimulators than SAC treated in vitro. The results indicate that Se enhances DTH by promoting antigen presentation.
Xia
H
H
Institute of Oncology, Beijing.
Zhang
Y
Y
D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012643:Selenium / Q000494:pharmacology*; D018038:Sodium Selenite
D012643:Selenium; D018038:Sodium Selenite