[Hormonal regulation of reproductive function in rats in response to cold stress in a context of chronic toluene poisoning].
Chronic toluene inhalation at a maximum permissible concentration (MPC) and 10-fold higher as well as cold stress result in a significant rise of blood prolactin in female rats. Cold stress in control animals causes a decrease in the level of gonad-releasing hormone (Gn-RH) in the hypothalamus. When exposed to toluene this reaction disappears. In 4 hours after estradiol administration control animals demonstrate an increase in the level of Gn-RH in the vascular organ of an end plate. Rats, exposed to toluene (in MPC concentration) and cold stress show a decrease in the level of hypothalamic Gn-RH. At a higher concentration of toluene the level of Gn-RH in the hypothalamus remains unchanged either after estradiol administration or in cold stress. Thus chronic toluene inhalation even at small concentrations changes hypothalamic reactivity in response to stress and hormonal stimuli.
Stepanov
M G
MG
Savchenko
O N
ON
Proĭmina
F I
FI
Altukhov
V V
VV
D000280:Administration, Inhalation; D000818:Animals; D003080:Cold Temperature; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*; D013312:Stress, Physiological / Q000503:physiopathology*; D014050:Toluene / Q000506:poisoning*
D007987:Gonadotropin-Releasing Hormone; D014050:Toluene; D004958:Estradiol; D011388:Prolactin
Gormonal'naia reguliatsiia reproduktivnoĭ funktsii u krys pri kholodovom stresse na fone khronicheskoĭ intoksikatsii toluolom.