Microbial metabolism of quinoline and related compounds. V. Degradation of 1H-4-oxoquinoline by Pseudomonas putida 33/1.
A bacterial strain was isolated with the ability to use 1H-4-oxoquinoline as the sole source of carbon, nitrogen and energy. On the basis of its physiological properties, this isolate was classified as Pseudomonas putida. 1H-3-Hydroxy-4-oxoquinoline, N-formylanthranilic acid, anthranilic acid and catechol were identified as intermediates in the degradation pathway. The latter was further degraded by ortho-cleavage. The enzymatic conversion of 1H-4-oxoquinoline into 1H-3-hydroxy-4-oxoquinoline requires oxygen and NADH. Experiments with 18O2 showed that the oxygen consumed in this enzymatic reaction is derived from the atmosphere.
Bott
G
G
Institut für Mikrobiologie, Universität Hohenheim.
Schmidt
M
M
Rommel
T O
TO
Lingens
F
F
D000332:Aerobiosis; D000693:Anaerobiosis; D002396:Catechols / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D010103:Oxygen Isotopes; D011549:Pseudomonas / Q000378:metabolism*; D015363:Quinolones / Q000378:metabolism*
D002396:Catechols; D010103:Oxygen Isotopes; D015363:Quinolones; D010100:Oxygen