[The Ca2+ reactivity and the subunit composition of myocardial actomyosin during the pyromecaine and pyrroxan treatment of experimental ischemia].
The treatment with pyromecaine and pyrroxan for 5 days was found to prevent disturbances of the physicochemical properties and the composition of the components of actomyosin complex of the rat heart left ventricle caused by experimental myocardial ischemia. Pyrroxan is able to change also the gene expression thereby leading to the appearance of a new isoform of myocardial myosin reminding by its characteristics the isoform of myosin of the rapidly contracting skeletal muscles.
Kaĭfadzhian
M A
MA
Dzhanpoladian
E G
EG
D000205:Actomyosin / Q000187:drug effects* / Q000378:metabolism; D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism*; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D004146:Dioxanes / Q000627:therapeutic use*; D004147:Dioxins / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010446:Peptide Fragments / Q000187:drug effects* / Q000378:metabolism; D011759:Pyrrolidines / Q000627:therapeutic use*; D051381:Rats
D000317:Adrenergic alpha-Antagonists; D000889:Anti-Arrhythmia Agents; D004146:Dioxanes; D004147:Dioxins; D010446:Peptide Fragments; D011759:Pyrrolidines; C000661:bumecain; D000205:Actomyosin; D002118:Calcium; C009143:proroxan
Ca2+-reaktivnost' i sub''edinichnyĭ sostav aktomiozina miokarda pri lechenii éksperimental'noĭ ishemii piromekainom i pirroksanom.