[Detection and significance of anti-pre S2 in patients with hepatitis B and HBsAg carriers].
We studied anti-Pre S2 by ELISA incorporating a synthetic peptide corresponding to the pre S2 (120-150) sequence and a monoclonal anti-human IgG, conjugated with peroxidase in 139 patients with hepatitis B and HBsAg carriers. The positive rate was 90% inpatients with acute-hepatitis 6.7% in chronic active hepatitis and 2.5% in persistent hepatitis. No positive case was seen in the HBsAg carriers. These findings indicate that anti-pre S2 may contribute to virus clearance and early diagnosis. The coexistence of anti-pre S2 with pre-S2 antigen was found only in patients with acute hepatitis, and anti-pre S2 may be coexistent with HBeAg in acute hepatitis, whereas all HBeAg positive patients with chronic hepatitis and HBsAg carriers lacked anti-pre S2. Comparing with anti-HBc IgM, anti-HBs and anti-HBe, anti-pre S2 is an earlier antibody in humoral immune response to HBV infection during the acute phase of hepatitis.
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D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002353:Carrier State / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis / Q000276:immunology*; D006801:Humans; D011498:Protein Precursors / Q000032:analysis / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000032:analysis / Q000276:immunology*
D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens; D011498:Protein Precursors; D014759:Viral Envelope Proteins; C050807:presurface protein 2, hepatitis B surface antigen