title: Endothelial cell population dynamics in rat brain after local irradiation.
abstract: The dynamics of the endothelial cell population was investigated in the rat brain after local irradiation with different doses of X rays. A fluorescent-histochemical technique was used for the visualization of the cells. A decrease in endothelial cell number was observed within 1 day of irradiation with doses of 5-200 Gy. At this time the endothelial cell number had decreased by up to 15% compared with the pre-treatment values. This early dose-independent loss in cell number was maintained for up to 1 month after irradiation. This was then followed by a slow dose-independent decrease in cell density up to 6 months after exposure. Subsequently the depletion of the endothelial cell population exposed to 40 and 60 Gy continued. After a dose of 25 Gy an abortive recovery of cell numbers occurred followed by an abrupt depletion of the endothelial cell population. The possible mechanisms of such changes are discussed.
authors.affiliation: Institute of Biological Physics, Academy of Sciences of the USSR, Moscow Region.
authors.forename: N V
authors.initials: NV
authors.lastname: Ljubimova
authors.forename: M K
authors.initials: MK
authors.lastname: Levitman
authors.forename: E D
authors.initials: ED
authors.lastname: Plotnikova
authors.forename: L Kh
authors.initials: LKh
authors.lastname: Eidus
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000528:radiation effects* / Q000648:ultrastructure; D002452:Cell Count; D004307:Dose-Response Relationship, Radiation; D004727:Endothelium / Q000528:radiation effects; D008297:Male; D008854:Microscopy, Electron; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors