The G protein connection: molecular basis of membrane association.
Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.
Spiegel
A M
AM
Molecular Pathophysiology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
Backlund
P S
PS
Butrynski
J E
JE
Jones
T L
TL
Simonds
W F
WF
D000595:Amino Acid Sequence; D002070:Butadienes / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism*; D045782:Hemiterpenes; D008563:Membrane Lipids / Q000378:metabolism*; D008969:Molecular Sequence Data; D019814:Myristic Acid; D009227:Myristic Acids / Q000378:metabolism; D010420:Pentanes
D002070:Butadienes; D045782:Hemiterpenes; D008563:Membrane Lipids; D009227:Myristic Acids; D010420:Pentanes; C005059:isoprene; D019814:Myristic Acid; D019204:GTP-Binding Proteins