[Synthesis of alkyl 2,6-dimethyl-(substituted or unsubstituted furyl)-1,4-dihydropyridine-3,5-dicarboxylates].
Calcium antagonists are drugs that selectively block potential dependent Ca(2+)-channel and inhibit Ca2+ withdrawal on cell membrane. These drugs are used to treat cardiovascular or cephalovascular diseases. 1,4-Dihydropyridine derivatives in comparison with other drugs, have higher potency and selectivity on Ca(2+)-antagonists. They are vasodilators and hypotensives. In this paper, eleven new dihydropyridine derivatives were prepared with the method of Hantzsch and were characterized on the basis of elemental analysis, infrared spectroscopy (IR) and proton nuclear magnetic resonance (1HNMR). The solubility in water, stability to heat and Ca(2+)-antagonistic activity of the new compounds were reported.
Zhang
Y H
YH
Department of Chemistry, Shaanxi Normal University, Xi'an.
Zhang
Z Q
ZQ
Wu
Q
Q
D002121:Calcium Channel Blockers / Q000138:chemical synthesis*; D004095:Dihydropyridines / Q000138:chemical synthesis*; D005663:Furans / Q000302:isolation & purification*
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D005663:Furans