title: Studies on selenate and selenite absorption by sheep ileum using an everted sac method and an isolated, vascularly perfused system.
abstract: 1. Using everted sacs of sheep ileum, selenate uptake was shown to be more rapid than selenite uptake. 2. Sulphate, thiosulphate and ouabain all inhibited the uptake of selenate. A Na+K(+)-ATPase is probably responsible for energizing the ileal brush-border transport of selenate. 3. The isolated, vascularly perfused ileum was shown to absorb selenate more rapidly than selenite. 4. The perfusion system described would appear to be a useful tool for studying the kinetics of intestinal absorption and the measurement of metabolic transformations within the mucosa.
authors.affiliation: Wallaceville Animal Research Center, Ministry of Agriculture and Fisheries, Upper Hutt, New Zealand.
authors.forename: J C
authors.initials: JC
authors.lastname: Turner
authors.forename: P J
authors.initials: PJ
authors.lastname: Osborn
authors.forename: S M
authors.initials: SM
authors.lastname: McVeagh
mesh_terms: D000818:Animals; D007082:Ileum / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D064586:Selenic Acid; D020887:Selenious Acid; D012643:Selenium / Q000378:metabolism*; D018036:Selenium Compounds; D012756:Sheep / Q000378:metabolism*; D013431:Sulfates / Q000494:pharmacology; D013885:Thiosulfates / Q000494:pharmacology
chemical_list: D018036:Selenium Compounds; D013431:Sulfates; D013885:Thiosulfates; D010042:Ouabain; D020887:Selenious Acid; D012643:Selenium; D064586:Selenic Acid