Experimental pathophysiological correlates of clinical symptomatology in peripheral neuropathic pain syndromes.
Recent advances in the study of nerve pathophysiology in experimental models of nerve and spinal root injury indicate a striking parallel between the abnormal electrical behavior of sensory axons and clinical symptomatology. In conjunction with central pain processes, these pathophysiological mechanisms can account for many of the major features of neuropathic pain syndromes.
Rappaport
Z H
ZH
Department of Neurosurgery, Hadassah University Hospital, Jerusalem, Israel.
Devor
M
M
D000818:Animals; D001369:Axons / Q000502:physiology; D006801:Humans; D009437:Neuralgia / Q000503:physiopathology*; D009619:Nociceptors / Q000503:physiopathology; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000503:physiopathology; D013126:Spinal Nerve Roots / Q000293:injuries* / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology*