Severe monochlorobenzene-induced liver cell necrosis.
Benzene derivatives can induce severe liver cell necrosis in animals. A case of a 40-year-old man whose daily consumption of alcohol was 200 g and who had a severe monochlorobenzene-induced liver necrosis is described. Liver biopsy specimen showed centrilobular and mediolobular necrosis, similar to that in mice after experimental bromobenzene administration. Monochlorobenzene serum concentration, assayed from day 3 to day 15 after poisoning, decreased monoexponentially with a half-life of 40.3 hours. Prostaglandin E1 was administered from day 3 to day 8. The patient ultimately recovered. The mechanism of monochlorobenzene-induced liver injury and the possible aggravating role of chronic alcohol consumption are discussed.
Babany
G
G
Service d'Hépatologie, (INSERM U24), Hôpital Beaujon, Clichy, France.
Bernuau
J
J
Cailleux
A
A
Cadranel
J F
JF
Degott
C
C
Erlinger
S
S
Benhamou
J P
JP
D000328:Adult; D000437:Alcoholism / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D002722:Chlorobenzenes / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000097:blood / Q000473:pathology; D008297:Male; D009336:Necrosis
D002722:Chlorobenzenes; C031294:chlorobenzene