The plasma sex steroid binding protein (SBP or SHBG). A critical review of recent developments on the structure, molecular biology and function.
Significant developments have taken place within the past five years on the characterization, molecular biology and function of the plasma sex steroid-binding protein, SBP (or sex hormone binding globulin, SHBG). During the span of that time, amino acid sequences of two SBPs have been established, amino acid residues in the steroid-binding site have been identified, the structure of the human SBP gene has been deduced and evidence for the possible existence of a SBP membrane receptor has been presented. This review covers the salient aspects of these and other developments including a critical analysis of the various proposed models and interpretations with regards to the structure, evolution, molecular biology and function of SBP.
Petra
P H
PH
Department of Obstetrics & Gynecology, University of Washington, Seattle 98195.
D000595:Amino Acid Sequence; D001665:Binding Sites; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D012738:Sex Hormone-Binding Globulin / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure
D012738:Sex Hormone-Binding Globulin