Telomeric location of retroviral oncogenes in humans.
The position relative to centromeres and telomeres has been investigated in 42 proto-oncogenes that have been localized in specific bands of the human chromosomes. It turned out that the 26 retroviral oncogenes had a predominant telon territory (near telomeres). The difference from the non-retrovirally transduced oncogenes is significant (p less than 0.01). Moreover, all oncogenes studied avoid the shortest and the longest arms. The results support the idea that genes with different properties tend to have different gene territories within the human chromosomes.
Lima-de-Faria
A
A
Department of Genetics, University of Lund, Sweden.
Mitelman
F
F
Blomberg
J
J
Pfeifer-Ohlsson
S
S
D002503:Centromere; D002877:Chromosomes, Human; D006801:Humans; D009857:Oncogenes / Q000235:genetics*; D011519:Proto-Oncogenes / Q000235:genetics; D012190:Retroviridae / Q000235:genetics*; D016615:Telomere