Biochemical studies following ovulation induction with clomiphene citrate and human menopausal gonadotropin in infertile Indian women.
Biochemical studies were done in 65 anovulatory women before and following induction of ovulation with ethinyl estradiol/clomiphene citrate/human chorionic gonadotropin and also clomiphene citrate/human menopausal gonadotropin/human chorionic gonadotropin to determine the metabolic adverse effects, if any, of such therapy. Significant increases occurred in lipids and lipoprotein levels, while minor changes were seen in liver function enzymes and fasting blood sugar. Sialic acid decreased significantly after therapy in both the regimens, and both induction therapies seem to be free of adverse metabolic effects of hormones. On comparison with normal ovulatory women, this study suggests that some of the biochemical parameters can serve as reliable indicators of ensuing ovulation.
Chaudhuri
C
C
Department of Biochemistry, University College of Science, Calcutta, India.
Mukherjea
M
M
Chakraborty
B N
BN
D000328:Adult; D006063:Chorionic Gonadotropin; D002996:Clomiphene; D004912:Erythrocytes / Q000032:analysis; D004997:Ethinyl Estradiol; D005260:Female; D006801:Humans; D007194:India; D007247:Infertility, Female / Q000097:blood* / Q000188:drug therapy; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000201:enzymology; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy
D006063:Chorionic Gonadotropin; D008055:Lipids; D008074:Lipoproteins; D002996:Clomiphene; D004997:Ethinyl Estradiol