title: Acute megakaryocytic leukemia (AMKL) with major myelofibrosis in an infant. Diagnosis by liver biopsy and response to treatment.
abstract: An infant presented with enlarged liver and spleen and profound pancytopenia. Severe marrow fibrosis impeded the diagnosis which was achieved by liver biopsy: Fibrosis surrounded foci of blasts which were shown by immunologic markers to originate from the megakaryocytic lineage. Complete sustained remission was obtained by low-dose aracytine therapy. The child was disease-free at 40 months' follow up.
authors.affiliation: Laboratory d'Hématologie, Hôpital Bicêtre, Kremlin-Bicêtre, France.
authors.forename: D
authors.initials: D
authors.lastname: Garel
authors.forename: F
authors.initials: F
authors.lastname: Mielot
authors.forename: P
authors.initials: P
authors.lastname: Gaulard
authors.forename: J
authors.initials: J
authors.lastname: Quillard
authors.forename: J P
authors.initials: JP
authors.lastname: Dommergues
authors.forename: G
authors.initials: G
authors.lastname: Tchernia
mesh_terms: D001706:Biopsy; D003561:Cytarabine / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007947:Leukemia, Megakaryoblastic, Acute / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008099:Liver / Q000473:pathology*; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications*; D012074:Remission Induction / Q000379:methods
chemical_list: D003561:Cytarabine