[The dependence of the formation of stress stomach ulcers on the function of the hypothalamo-hypophyseal-adrenal cortical system].
The effect of supraphysiological doses of corticosteroids on mucosal ulceration of stomach was studied in rats. Cortisol (30 mg/100 g) blocked the PACS. During the PACS block, ulcerogenic properties of stressor increased. This effect was reduced by subsequent corticosterone replacement therapy. The new concept of supraphysiological doses of corticosteroids effect is discussed. The stomach ulceration seems to result from the corticosteroid insufficiency.
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D000305:Adrenal Cortex Hormones / Q000097:blood; D000818:Animals; D005753:Gastric Mucosa / Q000473:pathology; D005790:General Adaptation Syndrome / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D013997:Time Factors
D000305:Adrenal Cortex Hormones; C021650:hydrocortisone acetate; D006854:Hydrocortisone
Zavisimost' obrazovaniia stressornykh iazv zheludka ot sostoianiia gipotalamo-gipofizarno-adrenokortikal'noĭ sistemy.