Relationships between obesity and ischaemic heart disease in type II diabetic subjects homozygous for the apoprotein E3 allele.
The purpose of the present study was to evaluate the influence of obesity on ischaemic heart disease frequency in a well-documented type II diabetic population. To eliminate one of the possible sources of variability for plasma lipid concentrations, only subjects showing the apoprotein E phenotype, indicative of homozygosity for the epsilon 3 allele (i.e. an E3/E3 genotype), have been recruited. A larger prevalence of ischaemic heart disease was noticed among obese patients as compared to non-obese or merely overweight subjects according to a higher frequency of hypertension and to higher triglyceride concentrations. These results corroborate the hypothesis of a common pathogenesis of the major cardiovascular risk factors.
Boemi
M
M
Division of Diabetology and Metabolic Diseases, I.N.R.C.A., Ancona, Italy.
Romagnoli
F
F
De Tommaso
G
G
Ricciotti
R
R
Fumelli
P
P
D000483:Alleles; D053318:Apolipoprotein E3; D001057:Apolipoproteins E / Q000235:genetics*; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D009765:Obesity
D053318:Apolipoprotein E3; D001057:Apolipoproteins E