[Relationship between mucin histochemical changes at the resection margin and rectal cancer recurrence after anterior resection].
The correlation between the presence of sialomucins at the resection margin identified by high iron diamine-alcian blue (HID-AB) histochemical stain and the subsequent anastomotic recurrence of the tumor was studied retrospectively in 64 rectal cancer patients at the stage of Dukes' B who underwent radical anterior resection. It was found that fourteen of 27 patients (51.9%) with a sialomucins predominant pattern at either resection margin suffered from tumour recurrence compared with 4 of 37 patients (10.8%) with a sulphomucin predominant pattern (P less than 0.001). Abnormal mucus production at the resection margin in patients treated for rectal carcinoma appears to identify those with a higher risk of anastomotic recurrence.
Wang
Q
Q
Changzheng Hospital, Second Military Medical University, Shanghai.
D000328:Adult; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism*; D009092:Mucous Membrane / Q000378:metabolism; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D012004:Rectal Neoplasms / Q000378:metabolism* / Q000601:surgery; D012007:Rectum / Q000378:metabolism; D052116:Sialomucins
D009077:Mucins; D052116:Sialomucins; C012564:sulfomucin