[Bombesin, dermorphin, physalaemin and sauvagine: effects on superficial and depth EEG tracings in epileptic and non-epileptic rats].
The effects of bombesin, sauvagine, physalaemin and dermorphin on rat CNS were observed. These peptides were administered to non-epileptic and epileptic rats: SEEG and DEEG were recorded. On the normal electrical background activity of rat brain only physalaemin had no effect. All the other peptides gave rise to slow activity with different duration. In the epileptic rat only sauvagine showed no effect whilst physalaemin reduced the epileptic activity, bombesin seemed to strengthen the action of metrazol and dermorphin blocked it at the onset. These observations will undergo FFT (Fast Fourier Transform) analysis.
de Romanis
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Dipartimento di Scienze Neurologiche, Università degli Studi di Roma La Sapienza.
Sopranzi
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D029845:Amphibian Proteins; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology*; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D036361:Peptide Hormones; D010455:Peptides / Q000494:pharmacology*; D010803:Physalaemin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D015320:Tachykinins / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D029845:Amphibian Proteins; D000701:Analgesics, Opioid; D009842:Oligopeptides; D018847:Opioid Peptides; D036361:Peptide Hormones; D010455:Peptides; D015320:Tachykinins; D014665:Vasodilator Agents; D010803:Physalaemin; C030058:dermorphin; C025727:sauvagine; D001839:Bombesin
Bombesina, dermorfina, fisalemina e sauvagina: effetti sui tracciati SEEG e DEEG nel ratto epilettico e non.