[The molecular mechanisms of the interaction of hormonal receptors coupled with G-proteins].
In recent years, quite a few structures of the genes coding membrane-bound hormonal receptors, have been revealed, and the recombinant receptors were cloned in heterogeneous systems. The role of the specific sites of a receptor molecule in the latter's functions is reviewed on example of the beta-adrenergic receptor. These functions involve ligand recognition, signal transmission to the GTP-binding protein, and desensitisation of the receptor. Different procedures of the receptor purification are compared. The data on beta-adrenergic modification by serine protease inhibitors and the homology between beta-receptor and chymotrypsin obtained by the authors, are discussed.
Voeĭkov
V L
VL
Kiselev
O G
OG
D000818:Animals; D004347:Drug Interactions; D019204:GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D011485:Protein Binding / Q000502:physiology; D011487:Protein Conformation; D011943:Receptors, Adrenergic, beta / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*
D008024:Ligands; D011943:Receptors, Adrenergic, beta; D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins
Molekuliarnye mekhanizmy vzaimodeĭstviia gormonal'nykh retseptorov, sopriazhennykh s G-belkami.