Dynemicins O, P and Q: novel antibiotics related to dynemicin A isolation, characterization and biological activity.
New antibiotics, dynemicins O (3), P (4) and Q (5), were isolated from the culture broth of Micromonospora chersina M956-1, the dynemicin A (1)-producing strain. An ethyl acetate extract of a tank culture was roughly separated by a column of Diaion SP-800 and was further purified by combining a variety of column chromatographies to afford a few mg of compounds 3, 4 and 5. Their structures, analyzed from the spectral data, had a bridging phenylene group, a vic-diol and an oxo group in place of the respective 1,5-diyn-3-ene bridge, the epoxide ring and the carboxyl group in dynemicin A. Their biological activities were evaluated against bacteria and tumor cells.
Miyoshi-Saitoh
M
M
Institute of Applied Microbiology, University of Tokyo, Japan.
Morisaki
N
N
Tokiwa
Y
Y
Iwasaki
S
S
Konishi
M
M
Saitoh
K
K
Oki
T
T
D000475:Alkenes; D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002845:Chromatography; D004354:Drug Screening Assays, Antitumor; D053281:Enediynes; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000378:metabolism*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000475:Alkenes; D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D053281:Enediynes; C071792:dynemicin M; C071791:dynemicin O; C071790:dynemicin P; C071789:dynemicin Q; C061229:dynemicin A