title: Presumed Pneumocystis carinii choroiditis. Unifocal presentation, regression with intravenous pentamidine, and choroiditis recurrence.
abstract: Pneumocystis carinii choroiditis is a well-documented but rare infection that has been described as a bilateral, multifocal process. Treatment efficacy has not been well established. In this report, three cases of presumed P. carinii choroiditis that developed during aerosolized pentamidine therapy for the prophylaxis of P. carinii pneumonia are described. All patients had unilateral choroiditis, and two patients were first observed to have unifocal choroiditis. In all patients, choroidal lesions decreased in size with intravenous pentamidine treatment. Choroiditis exacerbated in the two unifocal cases after the frequency of maintenance intravenous pentamidine therapy was decreased. P. carinii choroiditis may appear as a unifocal, unilateral lesion that may represent an earlier stage of infection than previously described. Intravenous pentamidine therapy appears to control P. carinii choroiditis but may need to be continued to prevent exacerbation. Patients receiving prophylactic aerosolized pentamidine therapy are not protected against extrapulmonary disease, and presumed P. carinii choroiditis may serve as a marker for disseminated infection.
authors.affiliation: Department of Ophthalmology, Cleveland Clinic Foundation, OH 44195-5024.
authors.forename: R E
authors.initials: RE
authors.lastname: Foster
authors.forename: C Y
authors.initials: CY
authors.lastname: Lowder
authors.forename: D M
authors.initials: DM
authors.lastname: Meisler
authors.forename: S S
authors.initials: SS
authors.lastname: Huang
authors.forename: D L
authors.initials: DL
authors.lastname: Longworth
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000280:Administration, Inhalation; D000328:Adult; D002833:Choroiditis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000473:pathology; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006679:HIV Seropositivity / Q000150:complications; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010419:Pentamidine / Q000627:therapeutic use*; D016720:Pneumocystis Infections / Q000188:drug therapy* / Q000473:pathology; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000188:drug therapy; D012008:Recurrence
chemical_list: D010419:Pentamidine