Inhibitors of skin-tumor promotion. VIII. Inhibitory effects of euglobals and their related compounds on Epstein-Barr virus activation. (1).
Twelve euglobals from Eucalyptus globulus and their twenty-six related compounds were examined for their inhibitory effects on Epstein-Barr virus activation by a short-term in vitro assay. The results showed that most of the euglobals having monoterpene structures, and euglobal-III (8) had strong inhibitory activity. Grandinol (18), homograndinols (19 and 20), and compounds 26, 27, 28, and 32 showed stronger inhibitory effects. Based on the results, the structural requirements for the activity of these compounds were discussed.
Takasaki
M
M
Kyoto Pharmaceutical University, Japan.
Konoshima
T
T
Fujitani
K
K
Yoshida
S
S
Nishimura
H
H
Tokuda
H
H
Nishino
H
H
Iwashima
A
A
Kozuka
M
M
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D006801:Humans; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013729:Terpenes / Q000494:pharmacology*; D014775:Virus Activation / Q000187:drug effects*
D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes