The effect of intracerebroventricular administration of baclofen on food intake in rats.
In the present study the effects of intracerebroventricular (ICV) administration of baclofen (0.1-5.0 nmol) was investigated on food intake in non-fasted rats. Baclofen (1.0, 2.5 and 5.0 nmol) increased food consumption in a dose-related manner during the first 15-30 min after administration. The effects of baclofen (5.0 nmol) on feeding were prevented by pretreating the rats with the specific GABA-B receptor antagonist phaclofen (40 nmol, ICV). These results suggest that baclofen increases food intake in rats by an action at central GABA-B receptors.
Ebenezer
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Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, Portsmouth Polytechnic, Hampshire, UK.
D000818:Animals; D001259:Ataxia / Q000139:chemically induced / Q000503:physiopathology; D001418:Baclofen / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects
D011963:Receptors, GABA-A; C052329:phaclofen; D001418:Baclofen