[Malignant T-cell neoplasia during treatment with azathioprine and prednisone after kidney transplantation].
Patients receiving immunosuppressive treatment show an increased incidence of malignant lymphoproliferative disease, mainly in the form of B-lymphomata, on account of constant antigen stimulation from an implanted organ and/or impaired immunological defense which permit cells which have undergone mutation or have been transformed by viruses to proliferate. Malignant T-proliferative disease is rare in this patient category. The authors present a case in which a man treated with azathioprin and prednisone who had been well and without symptoms of rejection during a total of seven years after renal transplantation, which suggests that the T-cell neoplasia was due to the immunosuppressive treatment.
Olesen
L L
LL
Medicinsk afdeling C., Aalborg Sygehus.
Mølby
L
L
D001379:Azathioprine / Q000009:adverse effects*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D016399:Lymphoma, T-Cell / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000009:adverse effects*; D013997:Time Factors
D001379:Azathioprine; D011241:Prednisone
Malign T-celle neoplasi under azatioprin- og prednisonbehandling efter nyretransplantation.