[Chronic cytopenia associated with T8 lymphocytosis successfully treated with glucocorticoids].
We reported a prednisolone effective case of T 8 lymphocytosis. The patient was 83 years old male, who had suffered from hypoplastic anemia for more than 5 years before he admitted to our hospital. His blood picture was peculiar because adding to granulocytopenia, CD8 (+) large granular lymphocytes were dominant among his lymphocytes. A few days after administration of bolus methylprednisolone, prominent reticulocytosis and rapid improvement of anemia occurred and the latter continued for more than 1 year. We performed in vitro study on the mechanism of his cytopenias. The result of Southern blot analysis showed that his blood lymphocytes had a unique rearranged pattern of T cell receptor beta chain gene. Mononuclear cells had an inhibitory effect on autologous and allogenic CFU-E colony formation of bone marrow cells. These facts suggest that colony proliferating CD8 (+) lymphocytes had an inhibitory effect on erythropoiesis in vivo, and prednisolone blocked this inhibitory pathway in this patient.
Kagami
Y
Y
First Department of Internal Medicine, Nagoya University School of Medicine.
Murate
T
T
Ichikawa
A
A
Hotta
T
T
Saitou
H
H
D000368:Aged; D000369:Aged, 80 and over; D000741:Anemia, Aplastic / Q000188:drug therapy; D000945:Antigens, Differentiation, T-Lymphocyte; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D008218:Lymphocytosis / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D009503:Neutropenia / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use*; D012010:Red-Cell Aplasia, Pure / Q000188:drug therapy
D000945:Antigens, Differentiation, T-Lymphocyte; D011239:Prednisolone