Circulating immunoreactive endothelin in patients undergoing percutaneous transluminal coronary angioplasty.
Circulating immunoreactive endothelin (ir-ET) in the coronary sinus (CS) and the femoral artery (Ao) was measured in patients who underwent percutaneous transluminal coronary angioplasty (PTCA). Plasma ir-ET level in the CS was significantly increased from 1.6 +/- 0.8 pg/mL to 2.0 +/- 1.0 pg/mL after PTCA (P less than .05). Plasma ir-ET level in the Ao tended to increase after PTCA, but it was not significant. Plasma ir-ET level in the CS was not related to the plasma thromboglobulin level, plasma thrombin-antithrombin complex level, mean blood pressure, or heart rate. These results suggest that the increase of plasma ir-ET level in the CS may be associated with the coronary endothelial injury by PTCA.
Tahara
A
A
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Kohno
M
M
Yanagi
S
S
Itagane
H
H
Toda
I
I
Akioka
K
K
Teragaki
M
M
Yasuda
M
M
Takeuchi
K
K
Takeda
T
T
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000787:Angina Pectoris / Q000097:blood* / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D000990:Antithrombin III / Q000032:analysis; D003326:Coronary Circulation; D016232:Endothelins / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000032:analysis; D011863:Radioimmunoassay; D013954:Thyroglobulin / Q000097:blood
D016232:Endothelins; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D013954:Thyroglobulin; D010447:Peptide Hydrolases