Simultaneous screening and quantification of several nonopiate narcotic analgesics and phencyclidine in human plasma using capillary gas chromatography.
This paper describes a procedure for the quantitative determination of alfentanil, dextromoramide, fentanyl, methadone, pentazocine, pethidine, phenoperidine and phencyclidine in human plasma. Some drug metabolites were included in the study. The procedure involves a simple alkaline extraction technique and capillary gas chromatography separation followed by a nitrogen-selective detection. Concentrations as low as 10 micrograms/l can be routinely evaluated, making this method suitable for use in overdose drug screening, therapeutic drug monitoring and pharmacokinetic studies.
Kintz
P
P
Institut de Médecine Légale, Strasbourg, France.
Tracqui
A
A
Lugnier
A J
AJ
Mangin
P
P
Chaumont
A A
AA
D000701:Analgesics, Opioid / Q000097:blood*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010622:Phencyclidine / Q000097:blood*
D000701:Analgesics, Opioid; D010622:Phencyclidine