title: Modulation of bacterial binding to salivary pellicle by treatment with hydrophilizing compounds.
abstract: Two hydrophilizing agents, a branched polyethylene glycol derivative and a non-ionic cellulose ether (EHEC) bind to buffer-treated hydroxyapatite and prevent attachment of Streptococcus mutans. EHEC gives a more efficient surface modification, presumably due to a more complete surface coverage. Neither of the 2 hydrophilizing agents were effective on hydroxyapatite which had been pre-treated with saliva. In a small clinical trial, EHEC was found to be moderately effective in preventing plaque formation.
authors.affiliation: Department of Cariology, Faculty of Odontology, Göteborg, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Olsson
authors.forename: A
authors.initials: A
authors.lastname: Carlén
authors.forename: K
authors.initials: K
authors.lastname: Holmberg
mesh_terms: D000268:Adhesiveness; D000327:Adsorption; D001422:Bacterial Adhesion / Q000187:drug effects* / Q000502:physiology; D002482:Cellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D003741:Dental Deposits / Q000503:physiopathology*; D044622:Dental Pellicle; D003773:Dental Plaque / Q000517:prevention & control; D004311:Double-Blind Method; D017886:Durapatite; D005260:Female; D006801:Humans; D006882:Hydroxyapatites / Q000737:chemistry*; D008297:Male; D010865:Pilot Projects; D010919:Placebos; D011092:Polyethylene Glycols / Q000494:pharmacology*; D012463:Saliva / Q000502:physiology*; D013295:Streptococcus mutans / Q000187:drug effects* / Q000502:physiology
chemical_list: D006882:Hydroxyapatites; D010919:Placebos; D011092:Polyethylene Glycols; D002482:Cellulose; C068339:ethyl-2-hydroxyethylcellulose; D017886:Durapatite