title: Microbial O-carbamylation of novobiocin.
abstract: Novobiocin was inactivated by Streptomyces niveus US 2094 in fermentation. The inactivation product was isolated and characterized by NMR and MS as 2"-O-carbamylnovobiocin. The MICs of novobiocin and 2"-O-carbamylnovobiocin were determined for S. niveus strains.
authors.affiliation: Upjohn Laboratories, Upjohn Company, Kalamazoo, MI 49001.
authors.forename: M S
authors.initials: MS
authors.lastname: Kuo
authors.forename: D A
authors.initials: DA
authors.lastname: Yurek
authors.forename: D G
authors.initials: DG
authors.lastname: Chirby
authors.forename: J I
authors.initials: JI
authors.lastname: Cialdella
authors.forename: V P
authors.initials: VP
authors.lastname: Marshall
mesh_terms: D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D004352:Drug Resistance, Microbial / Q000502:physiology*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009675:Novobiocin / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects* / Q000378:metabolism
chemical_list: C071799:2''-O-carbamylnovobiocin; D009675:Novobiocin