title: Kappa opioid receptor-mediated depression of activity evoked in convergent dorsal horn cells by thermal and non-thermal noxious stimulation.
abstract: The response of convergent dorsal horn cells to tonic and phasic noxious heating and to noxious pinching was studied before and after topical application of a solution (30 nmol) of the kappa agonist U-50,488H to the dorsal surface of the spinal cord. U-50,488H depressed the discharge of convergent units evoked by thermal and mechanical nociceptive stimuli. The opiate antagonist WIN 44,441-3 reversed the effect of U-50,488H. It is concluded that kappa opioids are effective in preventing the depolarization of convergent dorsal horn neurons evoked by either thermal or non-thermal noxious stimuli.
authors.affiliation: Institute of Nutrition and Food Technology, University of Chile, Santiago.
authors.forename: A
authors.initials: A
authors.lastname: Hernández
authors.forename: C
authors.initials: C
authors.lastname: Paeile
authors.forename: H
authors.initials: H
authors.lastname: Pérez
authors.forename: T
authors.initials: T
authors.lastname: Pelissier
authors.forename: R
authors.initials: R
authors.lastname: Soto-Moyano
mesh_terms: D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000870:Anterior Horn Cells / Q000187:drug effects / Q000502:physiology*; D001392:Azocines / Q000494:pharmacology; D006358:Hot Temperature; D009292:Narcotic Antagonists / Q000494:pharmacology; D009619:Nociceptors / Q000502:physiology; D010812:Physical Stimulation; D011759:Pyrrolidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology*; D017473:Receptors, Opioid, kappa; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D000700:Analgesics; D001392:Azocines; D009292:Narcotic Antagonists; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; C035969:quadazocine