title: Staging non-small cell carcinoma of the lung using technetium-99m-labeled monoclonal antibodies.
abstract: A technetium-labeled monoclonal antibody was administered to 52 patients with non-small cell lung carcinoma, either to stage the mediastinum preoperatively or to detect distant metastases. Results from planar and tomographic imaging are compared to CT and histologic confirmation. Differences in detection rates and predictive values between imaging modalities are discussed. The authors conclude that imaging with a technetium-labeled monoclonal antibody is safe and accurate and may be useful for staging patients with either operable or inoperable non-small cell lung cancer.
authors.affiliation: NeoRx Corporation, Seattle, Washington.
authors.forename: S
authors.initials: S
authors.lastname: Friedman
authors.forename: K
authors.initials: K
authors.lastname: Sullivan
authors.forename: D
authors.initials: D
authors.lastname: Salk
authors.forename: W B
authors.initials: WB
authors.lastname: Nelp
authors.forename: R J
authors.initials: RJ
authors.lastname: Griep
authors.forename: D H
authors.initials: DH
authors.lastname: Johnson
authors.forename: M J
authors.initials: MJ
authors.lastname: Blend
authors.forename: R
authors.initials: R
authors.lastname: Aye
authors.forename: V
authors.initials: V
authors.lastname: Suppers
authors.forename: P G
authors.initials: PG
authors.lastname: Abrams
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008482:Mediastinum / Q000000981:diagnostic imaging; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging; D009367:Neoplasm Staging / Q000379:methods*; D009928:Organ Specificity; D010865:Pilot Projects; D011300:Preoperative Care; D011933:Reagent Kits, Diagnostic; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D011933:Reagent Kits, Diagnostic; D013667:Technetium