The effect of scheduling in children undergoing prophylactic cranial irradiation for acute lymphoblastic leukaemia.
Control of central nervous system (CNS) disease and overall survival have been analysed in a group of 829 children with leukaemia entered into the UKALL VIII trial to determine whether scheduling of the cranial irradiation is of prognostic significance. We show that short gaps in treatment do not influence prognosis and that current radiotherapy practice need not be modified.
Costello
S A
SA
Department of Radiation Oncology, Beatson Oncology Centre, Western Infirmary, Glasgow, U.K.
Jones
R D
RD
Barrett
A
A
D000367:Age Factors; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001921:Brain / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000517:prevention & control; D002648:Child; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000532:radiotherapy*; D011879:Radiotherapy Dosage
D000970:Antineoplastic Agents