Differential effects of baclofen and gamma-aminobutyric acid (GABA) on rat piriform cortex pyramidal neurons in vitro.
1. The effects of baclofen and GABA on rat piriform cortex neurons were investigated electrophysiologically using a brain slice preparation. 2. At resting potential GABA depolarized and baclofen hyperpolarized the cell, probably through activation of Cl and K conductances acting at GABAA and GABAB receptors, respectively. 3. The GABAA receptors were concentrated on the apical and basal dendrites near the cell body, while the baclofen-sensitive GABA receptors were concentrated particularly on the basal dendrites. 4. The different distributions of receptor localization must have functional consequences which remain to be elucidated.
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Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan.
Carpenter
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D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D004594:Electrophysiology / Q000379:methods; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D009830:Olfactory Bulb; D009833:Olfactory Pathways; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D001418:Baclofen