Time- and loading-dependence in the McKone model for dermal uptake of organic chemicals from a soil matrix.
McKone has recently proposed an innovative two-layer model for dermal uptake of organic chemicals from a soil matrix that explicitly includes variables for properties of the chemical, the soil, the skin, and the exposure. In this note, we investigate the joint time- and loading-dependencies implicit in the model by using MATHEMATICA to find and plot a closed-form function for the uptake fraction for six aromatic hydrocarbons.
Burmaster
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Alceon Corporation, Cambridge, Massachusetts 02238.
Maxwell
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D003198:Computer Simulation; D006801:Humans; D006838:Hydrocarbons / Q000493:pharmacokinetics*; D008954:Models, Biological; D011083:Polycyclic Compounds / Q000493:pharmacokinetics*; D012867:Skin / Q000378:metabolism*; D012984:Software; D012989:Soil Pollutants / Q000493:pharmacokinetics*; D013997:Time Factors
D006838:Hydrocarbons; D011083:Polycyclic Compounds; D012989:Soil Pollutants