The blood-brain barrier permeability in graded postischemic spinal cord reoxygenation in rabbits.
Postischemic blood-brain barrier permeability changes were studied using a rabbit spinal cord ischemia model followed by normoxic recirculation (group I) or graded postischemic reoxygenation (group II). No signs of Evans blue leakage were found in lumbar segments 3 h after normoxic blood recirculation. After 6 h, the fluorescence was apparent in the perivascular space and in the pericytes, followed by a massive penetration of the tracer into the neuropil and perikarya at 12 h survival; 18 h after normoxic reperfusion, the fluorescence was localized in the cytoplasm of the middle-sized and large neurons. Graded postischemic reoxygenation of lumbar segments applied during the same survival periods had a highly protective effect on vascular membrane permeability. The structural components of the vascular wall as well as neuropil and perikarya remained after its application entirely tracer free.
Orendácová
J
J
Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Czechoslovakia.
Marsala
M
M
Marsala
J
J
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D002463:Cell Membrane Permeability; D005070:Evans Blue; D005260:Female; D005609:Free Radicals; D006651:Histocytochemistry; D007511:Ischemia / Q000503:physiopathology; D008297:Male; D011817:Rabbits; D015427:Reperfusion Injury / Q000503:physiopathology; D013116:Spinal Cord / Q000098:blood supply*
D005609:Free Radicals; D005070:Evans Blue