Investigations on pharmacological and immunological properties of imuthiol.
An observation was made that imuthiol exerts inhibitory effect on hemolysins forming cells (PFC) and on NK cells activity. It also reduces the number of T lymphocytes (in vitro), increases the activity of interleukin-1 and of the lymph node permeability factor. Well recognized is also its protective effect on thymocytes against hydrocortisone. Imuthiol was found to enhance rosette formation and to stimulate stem cells and partly suppressor cells. It reduces the level of cAMP. Its effect on the circulatory system is negligible.
Giełdanowski
J
J
Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Błaszczyk
B
B
Raberger
G
G
Duś
D
D
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004050:Ditiocarb / Q000494:pharmacology* / Q000633:toxicity; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D009712:Nucleotides, Cyclic / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000276:Adjuvants, Immunologic; D007375:Interleukin-1; D009712:Nucleotides, Cyclic; D004050:Ditiocarb