Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer.
To examine whether a variant human oestrogen receptor gene, which differs from the wild-type gene in the B region, was associated with spontaneous abortion, obstetric histories of breast cancer patients with this variant were compared with those of breast cancer patients with the wild-type gene. In women with the B-variant, 50% of pregnancies ended in spontaneous abortion, compared with 10% for women homozygous for the wild-type gene. B-variant women also had a higher proportion of spontaneous abortions and a higher number of spontaneous abortions per woman than did those with the wild-type gene.
Lehrer
S
S
Department of Radiotherapy, Mount Sinai School of Medicine, New York, NY 10029.
Sanchez
M
M
Song
H K
HK
Dalton
J
J
Levine
E
E
Savoretti
P
P
Thung
S N
SN
Schachter
B
B
D000026:Abortion, Habitual / Q000150:complications / Q000235:genetics*; D001943:Breast Neoplasms / Q000032:analysis / Q000150:complications / Q000235:genetics*; D005069:Evaluation Studies as Topic; D005260:Female; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis; D011960:Receptors, Estrogen / Q000235:genetics*; D012189:Retrospective Studies
D012333:RNA, Messenger; D011960:Receptors, Estrogen