Ceftazidime concentrations in renal cysts.
Levels of ceftazidime (CAZ) in uninfected renal cysts of 25 patients were investigated. Seventeen patients received 2 g CAZ about 140 min prior to puncture of the cysts (group I), and eight patients were treated with 2 x 2 g CAZ one day before, and with a further dose of 2 g 2 h prior to puncture (group II). In eight cases (two of group I and six of group II) the concentration of the cyst fluid was also assessed at 4 h and 6 h after completion of the CAZ infusion. In group I, CAZ concentrations were 0.5 to 1.13, micrograms ml-1, mean 0.71; in group II CAZ concentrations were 3.6 to 6.7 micrograms ml-1, mean 5.55. At 4 h and 6 h after infusion the mean cyst concentrations were 4.4 and 2.9 micrograms ml-1, respectively.
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Urologische Abteilung, KKH Alt/Neuötting, Altötting, F. R. Germany.
Bromberger
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Adam
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D000328:Adult; D000368:Aged; D001706:Biopsy; D002442:Ceftazidime / Q000008:administration & dosage / Q000032:analysis* / Q000627:therapeutic use; D004322:Drainage; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D052177:Kidney Diseases, Cystic / Q000032:analysis* / Q000188:drug therapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011292:Premedication
D002442:Ceftazidime