[Comparative study between thiopental and propofol in short-duration anesthesia].
In a randomized study, 80 healthy unpremedicated female patients were included. For short gynaecological procedures (curettage) they were anaesthetized with either propofol 2 mg/kg (n = 40) or thiopentone 5 mg/kg (n = 40) in combination with nitrous oxide/oxygen (1/1). Supplementary doses of propofol (25 mg) or thiopentone (50 mg) were given when necessary during the procedure. Propofol caused a significant fall in arterial blood pressure (greater than thiopentone in diastolic pressure) and a decrease in heart rate (thiopentone did not change heart rate). Discomfort on injection was similar in both groups. Recovery times were shorter in propofol group: Patients opened their eyes at 1.3 minutes, were awake at 2.2 minutes and could seat with no help at 5.2 minutes. In the thiopentone group, there was a greater incidence of nausea. Propofol was associated with euphoria, "clear-headedness" and pleasant dreams more than thiopentone. We conclude that propofol is a good alternative to thiopentone in short operative procedures.
Monedero Rodríguez
P
P
Departamento de Anestesiología y Reanimación, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.
Panadero Sánchez
A
A
García Pedrajas
F
F
Carrera Hueso
J
J
Catalá Bauset
J C
JC
Arroyo Carreras
J L
JL
D000768:Anesthesia, General; D003243:Consciousness / Q000187:drug effects; D004107:Dilatation and Curettage; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D015994:Incidence; D009325:Nausea / Q000139:chemically induced / Q000453:epidemiology; D015742:Propofol / Q000009:adverse effects / Q000494:pharmacology; D013874:Thiopental / Q000009:adverse effects / Q000494:pharmacology; D013997:Time Factors
D013874:Thiopental; D015742:Propofol
Estudio comparativo entre tiopental y propofol en anestesias de corta duración.