Deficiency of the pyruvate dehydrogenase complex and of mitochondrial fatty acid oxidation.
Defects of the pyruvate dehydrogenase complex and of mitochondrial fatty acid oxidation are important causes of disease. Defects of pyruvate dehydrogenase may present in early childhood with severe CNS changes or, as lactic acidosis or later with ataxia. Defects of fatty acid oxidation may present with hypoglycaemic coma, myopathy, liver disease with encephalopathy, cardiomyopathy or sudden infant death. The investigation of both these groups of disorders is difficult and depends upon a combination of biochemical and molecular biology techniques.
Bindoff
L A
LA
Division of Clinical Neuroscience, Medical School, Newcastle upon Tyne, England.
Birch-Machin
M A
MA
Jackson
S
S
Singh Kler
R
R
Bartlett
K
K
Turnbull
D M
DM
D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008052:Lipid Metabolism, Inborn Errors / Q000201:enzymology; D008928:Mitochondria / Q000378:metabolism*; D010084:Oxidation-Reduction; D015325:Pyruvate Dehydrogenase Complex Deficiency Disease / Q000378:metabolism*
D005227:Fatty Acids