Ceftazidime monotherapy is as effective as ceftazidime combined with gentamicin in the treatment of febrile neutropenic patients.
To evaluate the efficacy of ceftazidime monotherapy in the empirical treatment of febrile neutropenic patients, a randomized trial was performed of ceftazidime (C) vs. ceftazidime and gentamicin (C + G) with the addition of teicoplanin (T) for those patients with a long intravenous line-associated infection. Success without modification at the end of treatment was seen in 32.7% (C), 28.3% (C + G), 52.4% (C + T) and 65.2% (C + G + T). Monotherapy with ceftazidime is as effective as when used in combination with an aminoglycoside in neutropenia.
Kinsey
S E
SE
Department of Haematology, University College and Middlesex School of Medicine, London, UK.
Machin
S J
SJ
Goldstone
A H
AH
D000380:Agranulocytosis / Q000150:complications*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002423:Cause of Death; D002442:Ceftazidime / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D005839:Gentamicins / Q000627:therapeutic use*; D006020:Glycopeptides / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000150:complications*; D016032:Randomized Controlled Trials as Topic; D017334:Teicoplanin
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D006020:Glycopeptides; D017334:Teicoplanin; D002442:Ceftazidime