Bactericidal activity of vancomycin, daptomycin, ampicillin and aminoglycosides against vancomycin-resistant Enterococcus faecium.
Daptomycin, vancomycin, ampicillin and aminoglycosides, alone or in combination, were tested for their bactericidal activity against 15 isolates of vancomycin-resistant Enterococcus faecium from immunocompromised children. The kill-kinetic studies at clinically achievable concentrations demonstrated that daptomycin alone or in combination with ampicillin had the greatest bactericidal activity.
Bingen
E
E
Laboratoire de Microbiologie, Hôpital Robert Debré Université Paris VII, France.
Lambert-Zechovsky
N
N
Leclercq
R
R
Doit
C
C
Mariani-Kurkdjian
P
P
D000617:Aminoglycosides; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003227:Conjugation, Genetic; D017576:Daptomycin; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology; D013290:Streptococcal Infections / Q000382:microbiology; D013291:Streptococcus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D010455:Peptides; D014640:Vancomycin; D000667:Ampicillin; D017576:Daptomycin