Strobilurin D and strobilurin F: two new cytostatic and antifungal (E)-beta-methoxyacrylate antibiotics from Cyphellopsis anomala (1).
Strobilurin D and strobilurin F, two new cytostatic and antifungal antibiotics of the (E)-beta-methoxyacrylate class, have been isolated from mycelial cultures of the basidiomycete Cyphellopsis anomala (Pers. ex Fr.) Sing. The structures were elucidated by spectroscopic methods. The antibiotics inhibit the growth of human and animal cells and a wide variety of fungi. Like strobilurins A and B, the new metabolites are potent inhibitors of respiration.
Weber
W
W
Lehrbereich Biotechnologie, Universität Kaiserslautern, Federal Republic of Germany.
Anke
T
T
Bross
M
M
Steglich
W
W
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification; D000935:Antifungal Agents / Q000302:isolation & purification; D001487:Basidiomycota / Q000032:analysis*; D002478:Cells, Cultured; D006224:Cricetinae; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D008689:Methacrylates; D015394:Molecular Structure; D000073739:Strobilurins; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D008689:Methacrylates; D000073739:Strobilurins; C065215:strobilurin F; C065217:strobilurin G