Long HIV-1 incubation periods and dynamics of transmission within a family.
The incubation period of human immunodeficiency virus type 1 (HIV-1) infection was studied in a family of five in which vertical and heterosexual transmission occurred from one index case. This investigation documented incubation periods of longer than 12 years in a mother and her daughter; although neither has symptoms, both are definitely infected and have very low CD4(+)-lymphocyte counts. The study confirmed the predictions of incubation periods longer than 10 years in a small proportion of infected individuals. It provides evidence that vertically HIV-1-infected teenagers can be expected to appear in the population.
Burger
H
H
Department of Medicine, State University of New York, Stony Brook 11794.
Belman
A L
AL
Grimson
R
R
Kaell
A
A
Flaherty
K
K
Gulla
J
J
Gibbs
R A
RA
Nguyun
P N
PN
Weiser
B
B
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000635:transmission*; D000293:Adolescent; D000328:Adult; D015496:CD4-Positive T-Lymphocytes; D002648:Child; D004279:DNA, Viral / Q000032:analysis; D005190:Family; D005192:Family Health; D005260:Female; D015483:HIV Antibodies / Q000032:analysis; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1 / Q000235:genetics / Q000254:growth & development* / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D012725:Sexual Behavior; D015819:Substance Abuse, Intravenous; D013997:Time Factors
D004279:DNA, Viral; D015483:HIV Antibodies