Comparative effects of xamoterol and digoxin in patients with mild to moderate heart failure. The Italian Xamoterol Multicenter Research Group.
Xamoterol, 200 mg b.d. was compared with digoxin 0.125 mg b.d. or t.d. in a 3-month double-blind trial in 178 patients with mild to moderate heart failure. Xamoterol and digoxin both significantly increased exercise duration, but greater changes were observed with xamoterol. Xamoterol also improved quality of life to a greater degree than digoxin, and was better tolerated.
D000318:Adrenergic beta-Agonists / Q000009:adverse effects / Q000627:therapeutic use*; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000503:physiopathology; D004077:Digoxin / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D006801:Humans; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D005082:Physical Exertion / Q000187:drug effects; D011412:Propanolamines / Q000009:adverse effects / Q000627:therapeutic use*; D017307:Xamoterol
D000318:Adrenergic beta-Agonists; D011412:Propanolamines; D004077:Digoxin; D017307:Xamoterol