Cell alterations induced by the large T-antigens of SV40 and polyoma virus.
The large T-antigens of SV40 and polyoma virus are nuclear, multifunctional proteins that are essential for replication of the respective viruses. They can also 'transform' cells in culture to varying extents; both can immortalise primary cells, and SV40 large T can additionally induce full transformation. Recently, p105Rb, the protein product of the anti-oncogene RB-1, has been shown to interact with both large T-antigens. SV40 large T-antigen also binds to a p105Rb related protein, p107. SV40 large T differs from that of polyoma virus in its ability to associate with another anti-oncogene product, p53. The significance of these properties to the transforming potential of both viruses is considered.
Dilworth
S M
SM
Department of Chemical Pathology, Royal Postgraduate Medical School, London, UK.
D000957:Antigens, Viral, Tumor / Q000235:genetics / Q000502:physiology*; D002472:Cell Transformation, Viral / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D011120:Polyomavirus / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D013539:Simian virus 40 / Q000235:genetics / Q000276:immunology / Q000502:physiology*
D000957:Antigens, Viral, Tumor