Alpha-ketoglutarate and postoperative muscle catabolism.
The hypothesis that muscle protein catabolism after trauma is associated with a shortage of alpha-ketoglutarate, rather than glutamine, was tested. Addition of alpha-ketoglutarate to postoperative total parenteral nutrition prevented the decrease in muscle protein synthesis and free glutamine that usually occurs after surgery. alpha-ketoglutarate supplementation may improve recovery after trauma.
Wernerman
J
J
Department of Anaesthesiology and Intensive Care, St Göran's Hospital, Karolinska Institute, Stockholm, Sweden.
Hammarqvist
F
F
Vinnars
E
E
D002763:Cholecystectomy; D004341:Drug Evaluation; D005973:Glutamine / Q000378:metabolism*; D006801:Humans; D007656:Ketoglutaric Acids / Q000008:administration & dosage / Q000494:pharmacology*; D009124:Muscle Proteins / Q000378:metabolism*; D009584:Nitrogen / Q000652:urine*; D010289:Parenteral Nutrition, Total; D011184:Postoperative Period; D012270:Ribosomes / Q000378:metabolism
D007656:Ketoglutaric Acids; D009124:Muscle Proteins; D005973:Glutamine; D009584:Nitrogen