Excretion of electrolytes, free cortisol and aldosterone-18-oxo-glucuronide in 24-hr urines of the Mongolian gerbil (Meriones unguiculatus): effect of lysine-vasopressin and adrenocorticotrophin administration, and of changes in sodium balance.
1. Administration of lysine-vasopressin (LVP, 1 IU/animal) strongly reduced electrolyte excretion in 24 hr urines of adult male Mongolian gerbils, but had no effect on free cortisol (C) or aldosterone-18-oxo-glucuronide (Aldo-gluc.) excretion. 2. (1-24) ACTH, given at a dosage of 20 IU/animal, increased C and Aldo-gluc. excretion but did not influence electrolyte excretion. 3. Fluid intake and potassium excretion were decreased in animals offered a control or a sodium-deficient diet; contrasting, excretion of C was stimulated. 4. In contrast to other rodents, Aldo-gluc. excretion showed no changes in Mongolian gerbils offered a sodium-deficient diet, but was diminished in animals either fed a control diet or given saline (154 mmol/l) as drinking water.
Fenske
M
M
Lehrstuhl für Tierphysiologie, Universität Bayreuth, FRG.
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000450:Aldosterone / Q000097:blood / Q000652:urine*; D000818:Animals; D003366:Cosyntropin / Q000494:pharmacology*; D003404:Creatinine / Q000652:urine*; D005849:Gerbillinae / Q000652:urine*; D006854:Hydrocortisone / Q000097:blood / Q000652:urine*; D008236:Lypressin / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000652:urine*; D012964:Sodium / Q000652:urine*
D003366:Cosyntropin; D000450:Aldosterone; D008236:Lypressin; D012964:Sodium; D003404:Creatinine; D011188:Potassium; D006854:Hydrocortisone