title: Octreotide-induced acute pancreatitis in a patient with acquired immunodeficiency syndrome.
abstract: Unremitting diarrhea is a common problem in patients with AIDS. We have reported the case of such a patient who was treated with the somatostatin analogue octreotide for chronic diarrhea and who had acute pancreatitis as a consequence of this therapy. We postulate that the possible mechanism for the pathogenesis of this pancreatic damage was octreotide-induced prevention of pancreatic exocrine secretion. We believe this acted as a "physiologic gallstone", inducing an attack of acute pancreatitis.
authors.affiliation: Division of Infectious Diseases, Maimonides Medical Center, Brooklyn, NY.
authors.forename: J D
authors.initials: JD
authors.lastname: Gradon
authors.forename: R H
authors.initials: RH
authors.lastname: Schulman
authors.forename: E K
authors.initials: EK
authors.lastname: Chapnick
authors.forename: D V
authors.initials: DV
authors.lastname: Sepkowitz
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000208:Acute Disease; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000009:adverse effects*; D010195:Pancreatitis / Q000139:chemically induced* / Q000209:etiology
chemical_list: D015282:Octreotide