[Regression of the changes developed in the adrenal cortex in hypercholesterolemia].
Administration of cholesterin to rabbits for 2 months results in its increased concentration in blood and in adrenal cortex. Adrenocorticocytes demonstrate a decreased nuclear-cytoplasmic ratio, decreased concentration of protein and RNA in cytoplasm, lowered succinate dehydrogenase and 3 beta-ol-++steroid dehydrogenase activity. In 2 months after abolishing cholesterin, a considerable part of the changes mentioned remains. If during this period dexamethasone, inhibiting the gland activity, is administered, the regression of the changes decelerates. Administration of the adrenal cortex activator--corticotropin--facilitates normalization of most of the parameters, altered in the gland under the effect of cholesterin administration.
Ryzhavskiĭ
B Ia
BIa
Vasil'eva
E V
EV
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage; D000818:Animals; D001699:Biometry; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000378:metabolism; D004195:Disease Models, Animal; D006937:Hypercholesterolemia / Q000378:metabolism* / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D011817:Rabbits
D002791:Cholesterol, Dietary; D000324:Adrenocorticotropic Hormone
Regressiia izmeneniĭ, razvivshikhsia v korkovom veshchestve nadpochechnikov pod vliianiem giperkholesterinemii.