title: Treatment of gonorrhea with sulbactam/ampicillin.
abstract: Between January and August, 1989, 36 men and 28 women with uncomplicated lower genital tract infections by Neisseria gonorrhoeae were given single intramuscular injections of sulbactam (500 mg)/ampicillin (1000 mg) together with 1 g oral probenecid. Cure rates that were obtained were 100% for women, 97.2% for men, 100% for patients with penicillinase-producing Neisseria gonorrhoeae (PPNG), and 98.4% for patients with non-PPNG. No serious side effects were encountered, and patient acceptance of the drug was good. A high proportion of patients had concurrent chlamydial infection. Sulbactam/ampicillin was found to be effective against gonococcal urethritis and cervicitis by both PPNG and non-PPNG but have little effect on concomitant chlamydial infections, especially in women.
authors.affiliation: Department of Medical Microbiology, University Hospital, Kuala Lumpur, Malaysia.
authors.forename: Y F
authors.initials: YF
authors.lastname: Ngeow
authors.forename: S
authors.initials: S
authors.lastname: Ramachandran
authors.forename: Y M
authors.initials: YM
authors.lastname: Cheong
mesh_terms: D000293:Adolescent; D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D013407:Sulbactam / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: C035444:sultamicillin; D000667:Ampicillin; D013407:Sulbactam