Autolysins are direct involved in the bactericidal effect caused by penicillin in wild type and in tolerant pneumococci.
The two pneumococcal autolytic enzymes (an N-acetylmuramoyl-L-alanine amidase and an endo-beta-1,4-N-acetylglucosaminidase) are directly involved in the penicillin-induced killing of Streptococcus pneumoniae. The activity of these lytic enzymes was efficiently controlled in tolerant mutants under physiological conditions.
López
R
R
Centro de Investigaciones Biológicas, C.S.I.C. Madrid, Spain.
Ronda
C
C
García
E
E
D000118:Acetylglucosaminidase / Q000235:genetics / Q000378:metabolism; D000483:Alleles; D001433:Bacteriolysis / Q000187:drug effects* / Q000235:genetics; D017038:Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; D009154:Mutation; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000235:genetics / Q000378:metabolism; D010403:Penicillin Resistance / Q000235:genetics; D010406:Penicillins / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics
D010406:Penicillins; D000118:Acetylglucosaminidase; D017038:Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; D009238:N-Acetylmuramoyl-L-alanine Amidase