title: Type 1 iodothyronine deiodinase is a selenium-containing enzyme.
abstract: Expression cloning in the Xenopus oocyte has led to the isolation of a complimentary DNA for Type I iodothyronine deiodinase. Site-directed mutagenesis confirmed the presence of a selenocysteine amino acid in the deiodinase protein. These findings provide a molecular explanation of the effect of Se status on thyroid hormone activity.
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry; D007453:Iodide Peroxidase / Q000737:chemistry* / Q000235:genetics; D012643:Selenium / Q000032:analysis*
chemical_list: D004247:DNA; D007453:Iodide Peroxidase; D012643:Selenium