Translational frameshift suppression in mouse mammary tumor virus and other retroviruses.
Retroviruses, related retroposons, and several RNA viruses use translational frameshifting in the expression of their polymerase genes. We use retroviruses, particularly mouse mammary tumor virus, to illustrate the model which reflects our current understanding of these site-specific frameshifting events. The model has two components, a shifty sequence that facilitates ribosome slippage, and a second signal, either RNA secondary structure or an unfilled ribosomal A site, that stalls the ribosome and increases the probability of slippage at the shifty site.
Majors
J
J
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Mo.
D000818:Animals; D001483:Base Sequence; D016368:Frameshift Mutation / Q000235:genetics*; D008325:Mammary Neoplasms, Experimental / Q000235:genetics; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D012367:RNA, Viral; D012190:Retroviridae / Q000235:genetics*; D012192:Retroviridae Infections / Q000235:genetics*; D013489:Suppression, Genetic / Q000235:genetics*
D012367:RNA, Viral