title: Spontaneous lymphocyte proliferation in severe periodontal disease: role of T and B cells.
abstract: Spontaneous proliferation of T cells, B cells and unseparated lymphocytes was studied in patients with severe periodontal disease and control subjects. In the patient group only, spontaneous lymphocyte proliferation was reduced, whereas B cell proliferation was enhanced. The findings offer further support for the existence of a disturbance in immune regulation in patients with severe periodontal disease.
authors.affiliation: Department of Periodontology, University of Wales College of Medicine, Health Park, Cardiff, UK.
authors.forename: A
authors.initials: A
authors.lastname: Amer
authors.forename: G
authors.initials: G
authors.lastname: Singh
authors.forename: C
authors.initials: C
authors.lastname: Darke
authors.forename: A E
authors.initials: AE
authors.lastname: Dolby
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001402:B-Lymphocytes / Q000276:immunology / Q000502:physiology*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D010510:Periodontal Diseases / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology