Comparative morphology and morphometry of alveolar macrophages from six species.
Pulmonary alveolar macrophages (PAM) were collected from normal, healthy mice, rats, dogs, cynomolgus monkeys, chimpanzees, and humans and evaluated for morphologic and morphometric characteristics. The PAM of mice, rats, and dogs were morphologically similar and had statistically similar frequency distributions for size. The cell size distribution for these three species was relatively homogeneous. The PAM of nonhuman primates and humans were morphologically heterogenous with sometimes prominent cytoplasmic vacuolation, irregular cell outlines, and increased numbers of multinucleated cells as compared to the PAM of rodents and dogs. The mean size of human PAM was statistically greater than that for all other species evaluated, including nonhuman primates. These data indicate that significant differences in PAM morphology and size exist among species.
Haley
P J
PJ
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico 87185.
Muggenburg
B A
BA
Weissman
D N
DN
Bice
D E
DE
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002452:Cell Count; D004285:Dogs; D006801:Humans; D008168:Lung / Q000166:cytology; D008252:Macaca fascicularis; D016676:Macrophages, Alveolar / Q000166:cytology* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D002679:Pan troglodytes; D051381:Rats; D013045:Species Specificity