Adult T cell leukemia accompanied by annular elastolytic giant cell granuloma.
We report a 74-year-old Japanese patient with adult T-cell leukemia who concurrently developed annular elastolytic giant cell granuloma. Initially, itchy granulomatous lesions developed on his face, nape of the neck and dorsa of the hands, but gradually erythematous plaques appeared on the back and lower limbs. The histology of the granulomatous lesions revealed coexistence of an epithelioid cell granuloma with giant cells that phagocytosed elastic fibres in the dermis and Pautrier's microabscesses in the overlying epidermis. Subsequent sequential histological studies of an erythematous plaque revealed the development of granulomatous changes in pre-existing lymphomatous lesions. Laboratory data revealed the presence of antibody to human T cell leukemia/lymphoma virus I and 14,200 white cells/mm3 in the peripheral blood with 2% atypical lymphocytes which eventually amounted to 30%, one month before his death.
Kuramoto
Y
Y
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Watanabe
M
M
Tagami
H
H
D000368:Aged; D001706:Biopsy; D003131:Combined Modality Therapy; D004547:Elastic Tissue / Q000473:pathology; D005050:Etretinate / Q000627:therapeutic use; D006101:Granuloma, Giant Cell / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D015458:Leukemia, T-Cell / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D011701:PUVA Therapy; D012878:Skin Neoplasms / Q000473:pathology*
D005050:Etretinate