title: [Observation for 3 years on the immune effects of hepatitis B vaccine in susceptible population].
abstract: Chinese-produced HB vaccine induced high levels of antibodies against HB surface antigen in susceptible population (babies born to mothers who were negative for HBsAg and people who were negative for all the HBV markers). Eight months after the first dose, 97.73 and 93.75 percent of the neonates who received 10 micrograms (group I) and 20 micrograms (group II) vaccines and 92.45 percent of the adults who received 20 micrograms vaccine (group III) developed anti-HBs with the S/N values of 42.12, 46.53 and 36.20, and gave effective protection rates (S/N greater than or equal to 10) of 86.36%, 89.58% and 79.25%, respectively. No significant difference was noted between these groups. After three years, the positive rates and the S/N values of anti-HBs were 17.1% and 3.70 in group I, 15.6% and 4.23 in group II, 20.4% and 4.04 in group III respectively. One month after booster injection in anti-HBs, the S/N values of anti-HBs were 85.12 in group I with 10 micrograms vaccine, 89.23 in group II with 30 micrograms vaccine and 90.82 in those aged 4-10 years with 10 micrograms vaccine. The infection rate in the neonates who were not vaccinated with HB vaccines (11.11%) was higher than those who were vaccinated (0%). So it is clear that Chinese-produced HB vaccines are safe and effective.
authors.forename: W
authors.initials: W
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006801:Humans; D007117:Immunization, Secondary; D007231:Infant, Newborn; D008297:Male; D014761:Viral Hepatitis Vaccines
chemical_list: D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens; D014761:Viral Hepatitis Vaccines