title: Rebound insomnia: its determinants and significance.
abstract: Rebound insomnia is a sleep disturbance that occurs on discontinuation of benzodiazepine hypnotic drugs. It has been reported in both patients and healthy normal subjects and is characterized by increased wakefulness above the person's baseline levels. This article reviews that available information regarding determinants, possible mechanisms, and clinical significance of rebound insomnia. It is concluded that rebound insomnia is a disturbance of one or two nights' duration that primarily follows discontinuation of short- to intermediate-acting benzodiazepines. It occurs at high doses of a given drug, beyond which no additional hypnotic efficacy is evident. There seem to be clear individual differences in the experience of rebound insomnia, but no prospective studies have established which differences predict rebound. It is likely to be avoided by initiating treatment with the lowest effective dose and tapering the dose upon discontinuation.
authors.affiliation: Henry Ford Hospital, Detroit, Michigan 48202.
authors.forename: T
authors.initials: T
authors.lastname: Roehrs
authors.forename: G
authors.initials: G
authors.lastname: Vogel
authors.forename: T
authors.initials: T
authors.lastname: Roth
mesh_terms: D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001569:Benzodiazepines; D006801:Humans; D012008:Recurrence; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines