Effects of 3,3',4,4'-tetrachlorobiphenyl (TCB) on ovaries of foetal mice.
Female C57/B1 mice were administered 3,3',4,4'-tetrachlorobiphenyl (TCB) on the 13th day of pregnancy. The TCB-amounts ranged between 1.5-15 mg/kg b.wt. and were given intraperitoneally. Ovaries of in utero treated females aged 28 days were prepared and microscopically analysed for the number of oocytes and follicles. No effect of TCB was observed until the dose of 15 mg giving a reduction of the germ cell number of the order of 40-50 per cent of the control figures. It was noticed that this decrease appeared in all stages of oocytes and follicles contrary to the situation after an exposure for ionizing irradiation. No significant change in the reproductive capacity was observed during a five months test period.
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Unit of Experimental Pathology and Risk Research, Swedish University of Agricultural Sciences, Uppsala.
D000818:Animals; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D010053:Ovary / Q000187:drug effects* / Q000196:embryology; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012098:Reproduction / Q000187:drug effects
D011078:Polychlorinated Biphenyls; C028451:3,4,3',4'-tetrachlorobiphenyl