title: Use of the Cytobrush for concurrent cytology and chlamydia sampling: a comparison of immunofluorescence and culture for detection of chlamydia.
abstract: Five hundred and thirty-three women attending a genitourinary medicine clinic underwent concurrent cytology and Chlamydia trachomatis screening using a Cytobrush (Medscand AB). In each case, the same Cytobrush was used to give a sample for direct immunofluorescence and culture. 11.1% of samples were positive by immunofluorescence, while 10.6% were positive by culture. This was a close agreement (Kappa = 0.875). The ability of the same instrument to be used for both cytology and chlamydial screening, where direct immunofluorescence is used for detection of chlamydiae, may allow more widespread screening for chlamydia to be practical.
authors.affiliation: Department of Genitourinary Medicine, St Thomas' Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Szarewski
authors.forename: A
authors.initials: A
authors.lastname: Pompey
authors.forename: D
authors.initials: D
authors.lastname: Cronin
authors.forename: J
authors.initials: J
authors.lastname: Bertrand
authors.forename: C
authors.initials: C
authors.lastname: Bradbeer
authors.forename: R N
authors.initials: RN
authors.lastname: Thin
mesh_terms: D000328:Adult; D002690:Chlamydia Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D002692:Chlamydia trachomatis; D003584:Cytological Techniques / Q000295:instrumentation* / Q000592:standards; D005069:Evaluation Studies as Topic; D005260:Female; D005455:Fluorescent Antibody Technique / Q000295:instrumentation* / Q000592:standards; D005831:Genital Diseases, Female / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D008131:London / Q000453:epidemiology; D008403:Mass Screening / Q000295:instrumentation / Q000592:standards; D010044:Outpatient Clinics, Hospital; D012680:Sensitivity and Specificity; D014626:Vaginal Smears / Q000295:instrumentation* / Q000592:standards