title: Bacterial defenses against oxidative stress.
abstract: Bacteria treated with low doses of oxidants such as hydrogen peroxide adapt to subsequent high doses of these oxidants by inducing the expression of numerous genes. The study of these genes and the roles they play in defending bacteria against oxidative damage has given general insights into what oxidants are hazardous to cells, what cell constituents are damaged by oxidants, and how cells sense and respond to oxidative stress.
authors.affiliation: Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892.
authors.forename: G
authors.initials: G
authors.lastname: Storz
authors.forename: L A
authors.initials: LA
authors.lastname: Tartaglia
authors.forename: S B
authors.initials: SB
authors.lastname: Farr
authors.forename: B N
authors.initials: BN
authors.lastname: Ames
mesh_terms: D004755:Enterobacteriaceae / Q000235:genetics* / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005609:Free Radicals; D015964:Gene Expression Regulation, Bacterial; D006861:Hydrogen Peroxide / Q000378:metabolism*; D006878:Hydroxides / Q000378:metabolism*; D017665:Hydroxyl Radical; D010084:Oxidation-Reduction; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D006878:Hydroxides; D013481:Superoxides; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide