Rejection-associated upregulation of the alpha/beta-T cell receptor expression on T cells of renal allograft recipients.
Peripheral T lymphocytes of renal allograft recipients were phenotyped for their expression of the CD3-T cell receptor (TCR) complex. The majority of T cells from patients with stable graft function had normal CD3 but diminished TCR alpha/beta heterodimer expression, while TCR gamma/delta + T cells were increased in some cases. Acute rejection was associated with an increase in TCR alpha/beta + T cells to normal levels.
Górski
A
A
Transplantation Institute, Warsaw Medical School, Poland.
Nowaczyk
M
M
Małdyk
M
M
Juskowa
J
J
Wyzgał
J
J
Modlińska
M
M
Bukowska
J
J
Morzycka-Michalik
M
M
D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis*; D016176:T-Lymphocyte Subsets / Q000187:drug effects; D015854:Up-Regulation
D007166:Immunosuppressive Agents; D016693:Receptors, Antigen, T-Cell, alpha-beta