title: Regional cerebral blood flow in schizophrenia: repeated studies during a psychotic episode.
abstract: Regional cerebral blood flow (rCBF) measurements and clinical ratings were performed on 17 schizophrenic patients and a subgroup of 10 medication-free patients before and after treatment. While clinically exacerbated patients had normal blood flow, patients in remission showed a redistribution of flow with lower values in frontal areas. Anteroposterior ratios correlated with the degree of behavioral disturbances, suggesting that the level of frontal lobe activity in schizophrenia may be a function of the patient's clinical state at the time of study.
authors.affiliation: Department of Psychogeriatrics, CBF-Lab, St. Lars Hospital, Lund, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Warkentin
authors.forename: A
authors.initials: A
authors.lastname: Nilsson
authors.forename: J
authors.initials: J
authors.lastname: Risberg
authors.forename: S
authors.initials: S
authors.lastname: Karlson
authors.forename: K
authors.initials: K
authors.lastname: Flekköy
authors.forename: G
authors.initials: G
authors.lastname: Franzén
authors.forename: L
authors.initials: L
authors.lastname: Gustafson
authors.forename: G
authors.initials: G
authors.lastname: Rodriguez
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000188:drug therapy; D012563:Schizophrenia, Paranoid / Q000000981:diagnostic imaging; D012565:Schizophrenic Psychology; D014980:Xenon Radioisotopes
chemical_list: D014150:Antipsychotic Agents; D014980:Xenon Radioisotopes