Liposomes from soya phospholipids as percutaneous drug carriers. 2nd communication: quantitative in vivo investigations with radioactively labelled liposomes.
The percutaneous absorption of liposomes (prepared from NAT 106) was investigated with radioactively labelled substances in comparison with percutaneous absorption without liposomes (controls) in vivo on the skin of young pigs. Radioactivity was monitored as a function of time in skin tissue, plasma or blood and in urine. Elevated tissue levels, increased absorption and renal elimination of the various liposomal preparations in comparison to the controls were measured.
Artmann
C
C
Institut für Medizinische Balneologie und Klimatologie, Ludwig-Maximilians-Universität, Munich, Fed. Rep. of Germany.
Röding
J
J
Ghyczy
M
M
Pratzel
H G
HG
D000287:Administration, Topical; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000493:pharmacokinetics; D008081:Liposomes / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*; D012867:Skin / Q000033:anatomy & histology* / Q000378:metabolism; D012869:Skin Absorption; D013670:Sodium Pertechnetate Tc 99m; D013025:Glycine max / Q000032:analysis*; D013462:Sulfur Radioisotopes; D013552:Swine; D014018:Tissue Distribution
D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids; D013462:Sulfur Radioisotopes; D006493:Heparin; D013670:Sodium Pertechnetate Tc 99m