Copper complexes of 1,10-phenanthroline and related compounds as superoxide dismutase mimetics.
In a preliminary study we tested CuSO4.5H2O, (Cu(II]2[3,5-diisopropylsalicylate]4.2H2O and a number of copper complexes of substituted 1,10-phenanthrolines for superoxide anion dismutase activity. It appeared that this activity depends on the ligands involved and might be governed by the redox potential of the Cu(I) complex/Cu(II) complex couple. The strong superoxide anion dismutase activity of Cu(II)[DMP]2 complex can be expected considering its high redox potential. Rather surprisingly is the superoxide anion dismutase activity of the Cu(I)[DMP]2 complex since it involves oxidation to Cu(II)[DMP]2 complex. From regression analysis it was established that steric and field effects of the substituents of the investigated phenanthrolines play an important role in SOD activity and therefore it is concluded that complex formation is important for the superoxide dismutase-like activity.
Bijloo
G J
GJ
Department of Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands.
van der Goot
H
H
Bast
A
A
Timmerman
H
H
D003300:Copper / Q000378:metabolism*; D003574:Cytochrome c Group / Q000378:metabolism; D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000378:metabolism; D009942:Organometallic Compounds / Q000378:metabolism; D010084:Oxidation-Reduction; D010618:Phenanthrolines / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism; D019820:Xanthine; D014969:Xanthine Oxidase / Q000378:metabolism; D014970:Xanthines / Q000378:metabolism
D003574:Cytochrome c Group; D005609:Free Radicals; D009942:Organometallic Compounds; D010618:Phenanthrolines; D014970:Xanthines; D013481:Superoxides; D019820:Xanthine; D003300:Copper; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; C025205:1,10-phenanthroline