Subunit selective alteration of hepatic glutathione transferases in spontaneously hypertensive rats.
1. The activities of glutathione (GSH) transferases in male, spontaneously hypertensive rats (SHR) and stroke-prone rats (SHR-SP) were different from those of normotensive male Wistar Kyoto rats (WKY). 2. These alterations of the enzyme activities were partly due to the changes in the levels of subunits 2 and 4. 3. Subunit selective alterations were observed in pathophysiological conditions, namely spontaneous hypertension. 4. The sex-related difference of GSH transferases in these animals was also discussed.
Lee
E
E
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Kobe, Japan.
Miki
Y
Y
Kariya
K
K
D000818:Animals; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism*; D006973:Hypertension / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012727:Sex Characteristics
D005982:Glutathione Transferase