title: A PvuII restriction fragment length polymorphism of the glucose-6-phosphate dehydrogenase gene is an African-specific marker.
abstract: The site of a PvuII restriction fragment length polymorphism (RFLP) of the human glucose-6-phosphate dehydrogenase (G6PD) gene has been located in intron V, 60 bp upstream of G6PD exon VI. A population survey shows this RFLP to be specific for African populations, with frequencies of the rarer allele (PvuII type 2 site present) of 0.32-0.40 in Kenyans, Nigerians, Zambians, and West Indians. This allele has not been found in the European, Asian and Middle Eastern populations studied. Such population-specific markers may be useful in the study of population affinities and may provide insight into prehistoric migrations of peoples.
authors.affiliation: Department of Haematology, John Radcliffe Hospital, Oxford, UK.
authors.forename: M F
authors.initials: MF
authors.lastname: Fey
authors.forename: J S
authors.initials: JS
authors.lastname: Wainscoat
authors.forename: E C
authors.initials: EC
authors.lastname: Mukwala
authors.forename: A G
authors.initials: AG
authors.lastname: Falusi
authors.forename: T J
authors.initials: TJ
authors.lastname: Vulliamy
authors.forename: L
authors.initials: L
authors.lastname: Luzzatto
mesh_terms: D044383:Black People / Q000235:genetics*; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D005819:Genetic Markers; D005954:Glucosephosphate Dehydrogenase; C025630:CAGCTG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific