Effects of nifedipine and captopril on vascular capacitance of ganglion-blocked anesthetized dogs.
The hemodynamic effects of nifedipine and captopril at doses producing similar reductions in arterial pressure were studied in pentobarbital-anesthetized ventilated dogs after splenectomy during ganglion blockade with hexamethonium. Mean circulatory filling pressure (Pmcf) was determined during transient circulatory arrest induced by acetylcholine at baseline circulating blood volumes and after increases of 5 and 10 mL/kg. Central blood volumes (pulmonary artery to aortic root) were determined from transit times, and separately determined cardiac outputs (right atrium to pulmonary artery) were estimated by thermodilution. Nifedipine (n = 5) increased Pmcf at all circulating blood volumes and reduced total vascular capacitance without a change in total vascular compliance. Central blood volume, right atrial pressure, and cardiac output were increased with induced increases in circulating blood volume. In contrast, captopril (n = 5) did not alter total vascular capacitance, central blood volume, right atrial pressure, or cardiac output at baseline or with increased circulating volume. Thus, at doses producing similar reductions in arterial pressure, nifedipine but not captopril increased venous return and cardiac output in ganglion-blocked dogs.
Ogilvie
R I
RI
Clinical Pharmacology Division, Toronto Western Hospital, Ont., Canada.
Zborowska-Sluis
D
D
D000758:Anesthesia; D000818:Animals; D001784:Blood Gas Analysis; D001810:Blood Volume / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D005730:Ganglionic Blockers / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006584:Hexamethonium Compounds / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects*
D005730:Ganglionic Blockers; D006584:Hexamethonium Compounds; D002216:Captopril; D009543:Nifedipine