Familial incidence of C3 nephritic factor.
C3 nephritic factor (NEF) has been found in 3 siblings presenting different (or none) degrees of renal disease. Other relatives, including their dead father, suffered from a renal illness. In 2 of the siblings, NEF activity was restricted to IgG1 and IgG3 subclasses. Familial NEF incidence and a shared C3 allotype and a common HLA haplotype including BfS alleles for the 3 NEF-positive siblings suggest that at least in our cases genetical factors may be involved in NEF generation.
López-Trascasa
M
M
Immunology Unit, Hospital La Paz, Madrid, Spain.
Martín-Villa
J M
JM
Vicario
J L
JL
Marín
M A
MA
Martínez-Ara
J
J
García-Messeguer
M C
MC
Arnáiz-Villena
A
A
Fontán
G
G
D000293:Adolescent; D000328:Adult; D003176:Complement C3 / Q000032:analysis / Q000235:genetics; D003178:Complement C3 Nephritic Factor / Q000032:analysis / Q000235:genetics*; D003181:Complement C4 / Q000032:analysis; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000145:classification; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D003176:Complement C3; D003178:Complement C3 Nephritic Factor; D003181:Complement C4; D006680:HLA Antigens; D007074:Immunoglobulin G