Carvedilol increases the systemic bioavailability of oral digoxin.
The effects of a single oral dose of 25 mg carvedilol on the plasma and urinary kinetics of digoxin after an oral and intravenous 0.5 mg dose, were investigated in two separate double-blind, placebo-controlled, period-balanced cross-over studies in healthy male subjects. Carvedilol increased the mean maximum plasma concentration and the area under the plasma concentration time-curve of digoxin when administered orally. The effects were virtually confined to the first 4 h after dosing, and the apparent terminal disposition rate constant was not changed. Carvedilol did not alter the plasma and urinary kinetics of intravenously administered digoxin.
De Mey
C
C
SK & F-Institute for Applied Clinical Pharmacology, SKD, Göttingen, FRG.
Brendel
E
E
Enterling
D
D
D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001682:Biological Availability; D002227:Carbazoles / Q000494:pharmacology*; D000077261:Carvedilol; D004077:Digoxin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004311:Double-Blind Method; D004347:Drug Interactions; D004562:Electrocardiography; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011412:Propanolamines / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D004077:Digoxin