Inverse relationship between cortisol excretion rate and plasminogen activator inhibitor-1 (PAI-1) antigen and activity in premenopausal obese women.
The present study was undertaken in order to investigate the possibility of a relationship between plasminogen activator inhibitor-1 (PAI-1) and cortisol excretion rate in 15 obese women. We found a highly significant linear inverse correlation between cortisol excretion rate and both PAI-1 antigen (r = 0.79, P less than 0.001) and activity (r = 0.77, P less than 0.001). In addition, stepwise regression analysis showed that cortisol excretion rate maintained a strong negative relationship with PAI-1 antigen (significance level 0.03) and activity (significance level 0.003), when adjusted for other variables taken in examination (waist to hip ratio, body mass index, insulin, DHEAS, age). Even though this study only demonstrates a negative correlation, the possibility of a direct inhibitory effect of cortisol on PAI-1 production should be considered. In conclusion, the present study demonstrates an inverse correlation between cortisol excretion rate and PAI-1 antigen and activity, suggesting a possible role for cortisol in protecting obese women from reduced fibrinolytic activity.
De Pergola
G
G
Istituto di Clinica Medica, Endocrinologia e Malattie Metaboliche dell'Università di Bari, Italy.
De Mitrio
V
V
Cignarelli
M
M
Garruti
G
G
Giorgino
F
F
Meola
M
M
Giorgino
R
R
D000328:Adult; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine*; D009765:Obesity / Q000378:metabolism*; D015849:Plasminogen Inactivators / Q000097:blood* / Q000276:immunology; D012044:Regression Analysis
D015849:Plasminogen Inactivators; D003404:Creatinine; D006854:Hydrocortisone