[Purified FSH in small doses. Is this not the best current treatment of polycystic ovaries resistant to clomid? 73 cycles].
Sixteen infertile women with the Polycystic ovary syndrome were treated using stimulation of ovulation with purified FSH after Clomid had failed. We compared the results of giving a short course (19 cycles) with giving a long course (54 cycles). With the long course there were fewer cases of hyperstimulation--2 out of 54 cycles (3.70%) as against 1 in 19 cycles with a short course (5.26%). There were fewer changes in the programme needed--6 out of 54 cycles (3.7%) as against 7 cycles out of 19 (31.57%). Ovulatory cycles occurred more frequently in 46 out of 54 cycles (85.18%) as against 12 out of 19 (63.15%). In the long courses 14 pregnancies out of 46 ovulatory cycles occurred (30.43%) as against 3 pregnancies out of 12 cycles (25%). The level of successful pregnancy was much higher in couples who had no other sterility factors--85.10% for the long course as against 63.15% for the short course. In summary purified FSH is an excellent treatment for ovarian dysfunction that is resistant to Clomid. It is necessary to have 3.41 ovulatory cycles to obtain a pregnancy. In this work there were no multiple pregnancies out of the 17 pregnancies and the 3 cases of hyperstimulation that were noted were moderate.
Drapier-Faure
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Département de Gynécologie, Oncologie gynécologique, Sénologie et Médecine de la Reproduction, Hôpital Edouard-Herriot, Lyon.
D000328:Adult; D002985:Clinical Protocols / Q000592:standards; D002996:Clomiphene / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome
D002996:Clomiphene; D005640:Follicle Stimulating Hormone
FSH purifiée à petites doses. N'est-ce pas la meilleure thérapeutique actuelle des ovaires polykystiques résistant au Clomid? A propos de 73 cycles.