title: Regional localization by in situ hybridization of a human chromosome 9 marker tightly linked to the Friedreich's ataxia locus.
abstract: In order to determine the regional localization of the Friedreich's ataxia (FA) gene on chromosome 9, the DNA probe DR47 (D9S5), which detects a restriction fragment length polymorphism (RFLP) in tight linkage with the disease, was hybridized in situ to metaphase chromosomes. Our results enable the D9S5 locus to be assigned to the 9q12-q13 region, thus indicating that this is also the localization of the FA gene.
authors.affiliation: Dipartimento di Genetica e Microbiologia, A. Buzzati Traverso, dell'Università di Pavia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Raimondi
authors.forename: A
authors.initials: A
authors.lastname: Antonelli
authors.forename: A J
authors.initials: AJ
authors.lastname: Driesel
authors.forename: M
authors.initials: M
authors.lastname: Pandolfo
mesh_terms: D001345:Autoradiography; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D015342:DNA Probes; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008938:Mitosis; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D013132:Spinocerebellar Degenerations / Q000235:genetics*
chemical_list: D015342:DNA Probes; D005819:Genetic Markers