title: [Pharmacokinetics of human milk lactoferrin in intact mice and tumor-carrying animals].
abstract: Pharmacokinetics of iodine containing and native lactoferrin from human milk was studied in intact mice and the animals with Ehrlich ascites carcinoma. Both these antigens, native and I-lactoferrin, were similarly distributed in intact mice body. The same pharmacokinetics was found in tumor-bearing animals. Exogenous lactoferrin penetrated mainly into liver tissue, then simultaneously with bile--into small intestine and further into large intestine. Distinct accumulation of the glycoprotein was not found in tumor tissue.
authors.forename: N I
authors.initials: NI
authors.lastname: Kazachkina
authors.forename: E R
authors.initials: ER
authors.lastname: Nemtsova
authors.forename: R I
authors.initials: RI
authors.lastname: Iakubovskaia
authors.forename: T A
authors.initials: TA
authors.lastname: Karmakova
authors.forename: L M
authors.initials: LM
authors.lastname: Ivanova
authors.forename: A V
authors.initials: AV
authors.lastname: Sokolov
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D005260:Female; D007421:Intestine, Small / Q000378:metabolism; D007781:Lactoferrin / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008892:Milk
chemical_list: D007781:Lactoferrin
vernacular_title: Izuchenie farmakokinetiki laktoferrina zhenskogo moloka u intaktnykh mysheĭ i zhivotnykh-opukholenositeleĭ.