Influence of thymic fraction 5 on erythrocyte (Na+ + K+)-ATPase activity in hypercholesterolemic rabbits.
The effects of thymus fraction 5 injection on cholesterol, triglyceride and phospholipid levels in plasma and erythrocytes as well as on membrane-bound (Na+ + K+)-ATPase activity were investigated in rabbits fed a high-cholesterol diet for 3 months. While cholesterol feeding caused an increase in plasma and erythrocytes phospholipid levels, (Na+ + K+)-ATPase activity was found to be reduced. After high-cholesterol diet, the rabbits were given normal diet with or without thymosin F5 injections every other day for 21 days. Thymosin F5 treatment caused a significant decrease in plasma and erythrocyte phospholipid levels whereas membrane-bound (Na+ + K+)-ATPase activity was increased significantly. It is concluded that hypercholesterolemic lesions and the decreased erythrocyte ATPase activity may be eliminated by thymic extracts in rabbits.
Gökkuşu
C
C
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
Oz
H
H
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D006937:Hypercholesterolemia / Q000201:enzymology*; D010743:Phospholipids / Q000097:blood; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D010743:Phospholipids; D014280:Triglycerides; C033782:thymosin fraction 5; D013947:Thymosin; D002784:Cholesterol; D000254:Sodium-Potassium-Exchanging ATPase