title: 5-HT and benzodiazepine receptor ligands. III. Synthesis and receptor affinities of 1,2,4-triazolo[4',3':1,6]pyridazino[4,5-b]quinoline and 2,3-dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinoline-1-one derivatives.
abstract: The syntheses as well as 5-HT and Benzodiazepine receptor binding studies of some 1,2,4-Triazolo[4',3':1,6]piridazino[4,5-b]quinoline and 2,3-Dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinoline-1-one derivatives are reported. While the triazole-containing heterocycles are devoid of any biological activity, 2-benzyl-2,3-dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinoline-1-one shows some affinity for the central type of benzodiazepine receptors.
authors.affiliation: Dipartimento Farmaco Chimico Technologico, Università Banchi di Sotto, Siena, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Anzini
authors.forename: A
authors.initials: A
authors.lastname: Cappelli
authors.forename: S
authors.initials: S
authors.lastname: Vomero
authors.forename: M
authors.initials: M
authors.lastname: Botta
authors.forename: A
authors.initials: A
authors.lastname: Cagnotto
mesh_terms: D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism; D005442:Flumazenil / Q000378:metabolism; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000378:metabolism; D008024:Ligands; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*
chemical_list: D007546:Isoquinolines; D008024:Ligands; D011758:Pyrroles; D015363:Quinolones; D011963:Receptors, GABA-A; D011985:Receptors, Serotonin; D005442:Flumazenil; C037850:PK 11195