A new EcoRI polymorphism at the D21S13 locus.
The D21S13 locus has shown linkage to a gene for familial Alzheimer disease (FAD) on chromosome 21 (St. George-Hyslop et al. 1987). The limited informativeness of probes for this locus have hindered precise mapping of the FAD locus and analysis of nonallelic heterogeneity in FAD (Schellenberg et al. 1988; St. George-Hyslop et al. 1987). We describe a new EcoRI polymorphism at the D21S13 locus that may be useful for the further study of FAD families.
Pulst
S M
SM
Division of Neurology, Cedars-Sinai Medical Center, University of California, Los Angeles 90048.
Korenberg
J R
JR
Greenwald
J
J
Carbone
M
M
D000544:Alzheimer Disease / Q000235:genetics*; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D015246:Deoxyribonuclease EcoRI / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length
D015246:Deoxyribonuclease EcoRI