Influence of human plasma high density lipoproteins from septic patients on different functions of normal human neutrophils.
High Density Lipoproteins (HDL) from three patients with E. coli sepsis contained high, low and no Serum Amyloid Protein (Apo SAA), respectively. Preincubation of neutrophils from healthy persons for half an hour with sepsis HDL as well as normal HDL increased the phagocytosis, the stimulated nitroblue tetrazolium reduction, the chemotaxis and the random migrations of these cells. However, for all these functions, lower values were obtained after incubation with sepsis HDL containing high amounts of apo SAA than with normal HDL. A qualitative change of HDL might thus in part be responsible for the decreased function of neutrophils noted during the acute phase of bacterial infections.
Jarstrand
C
C
Department of Microbiology, Huddinge University Hospital, Stockholm, Sweden.
Holmquist
L
L
Wiernik
A
A
Akerlund
B
B
Carlson
L A
LA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001053:Apolipoproteins / Q000097:blood; D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004927:Escherichia coli Infections / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008075:Lipoproteins, HDL / Q000097:blood* / Q000494:pharmacology; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D000685:Serum Amyloid A Protein / Q000378:metabolism
D001053:Apolipoproteins; D008075:Lipoproteins, HDL; D000685:Serum Amyloid A Protein; C035165:apolipoprotein SAA; D009580:Nitroblue Tetrazolium