title: Effect of AICD patch electrodes on the diastolic pressure-volume curve in pigs.
abstract: Although the automatic implantable cardioverter defibrillator (AICD) is effective against malignant ventricular arrhythmias, the effects of AICD patches on left ventricular diastolic properties have not been defined. Accordingly, extrapericardial (group E, n = 5) or intrapericardial (group I, n = 6) AICD patches were implanted through a median sternotomy in 11 anesthetized pigs. Six weeks later, using a left thoracotomy, the hearts were arrested with hypothermic cardioplegia. A balloon catheter was inserted into the left ventricle through the aortic root, and pressure-volume curves were measured before and after sequential removal of patches and pericardium. A dense intrapericardial fibrotic reaction in group I was not present in group E. Normalized left ventricular filling volumes in group E were significantly larger at pressures of 5.1 to 10, 15.1 to 20, and 20.1 to 28 mm Hg compared with group I (p less than 0.05). We conclude that intrapericardial AICD patches adversely affect left ventricular diastolic pressure-volume relations and recommend that AICD patches be placed in the extrapericardial location clinically whenever possible.
authors.affiliation: Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032.
authors.forename: J S
authors.initials: JS
authors.lastname: Auteri
authors.forename: V
authors.initials: V
authors.lastname: Jeevanandam
authors.forename: M R
authors.initials: MR
authors.lastname: Bielefeld
authors.forename: J A
authors.initials: JA
authors.lastname: Sanchez
authors.forename: H M
authors.initials: HM
authors.lastname: Spotnitz
mesh_terms: D000818:Animals; D006328:Cardiac Catheterization; D003971:Diastole / Q000502:physiology*; D004554:Electric Countershock / Q000295:instrumentation*; D004567:Electrodes, Implanted; D005355:Fibrosis; D010496:Pericardium / Q000473:pathology; D019736:Prostheses and Implants / Q000009:adverse effects; D013552:Swine; D016277:Ventricular Function, Left / Q000502:physiology*