[Changes in the content of neuromediator amino acids in the brain of mice with a convulsive syndrome induced by the hyperactivation of CNS cholinergic structures].
Methods of thin-layer chromatography with the following elution and photometry were used to determine the amount of taurin, glycin and glutamate in mouse brain 20 and 60 min after injections of arecolin (10 mg/kg), nicotin (9 mg/kg), fluorostigmin (3 mg/kg) and picrotoxin (8 mg/kg). It was determined that seizures induced by these drugs are followed by raising of the levels of taurin (on 20-70%), glycin (after 60 min on 30-70%), glutamate (after 20 min--on 70-60%). The level of glutamate was lowered (by 40-80%) to 60 min after injections of nicotin, fluorostigmin and picrotoxin.
Astrov
V V
VV
Kutsenko
S A
SA
D000596:Amino Acids / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D008297:Male; D051379:Mice; D018377:Neurotransmitter Agents / Q000032:analysis / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*; D013577:Syndrome; D013997:Time Factors
D000596:Amino Acids; D018377:Neurotransmitter Agents; D011950:Receptors, Cholinergic
Izmenenie soderzhaniia neĭromediatornykh aminokislot v golovnom mozge mysheĭ na fone sudorozhnogo sindroma, vyzvannogo giperaktivatsieĭ kholinergicheskikh struktur TsNS.