title: [Antimicrobial activity of ceftazidime and its pharmacokinetics in patients with renal failure].
abstract: High antimicrobial activity of ceftazidime against clinical gram-positive (except Streptococcus viridans and S. faecalis) and gram-negative strains of microorganisms was shown. It was found that the drug dosing regimens required correction in cases with impaired excretion function of the kidneys. Hemodialysis lowered 2-4 times the drug blood levels.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Skala
authors.forename: V N
authors.initials: VN
authors.lastname: Nasonov
authors.forename: V L
authors.initials: VL
authors.lastname: Cherniakov
authors.forename: A G
authors.initials: AG
authors.lastname: Nekhorosheva
authors.forename: V A
authors.initials: VA
authors.lastname: Prokhorova
mesh_terms: D002442:Ceftazidime / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000378:metabolism; D006435:Renal Dialysis / Q000009:adverse effects
chemical_list: D002442:Ceftazidime
vernacular_title: Antimikrobnaia aktivnost' tseftazidima i ego farmakokinetika u bol'nykh s pochechnoĭ nedostatochnost'iu.