title: [Kinetic characteristics of neuroleptic binding sites on human lymphocytes].
abstract: The kinetics and equilibrium of the interaction of [3H]spiperone with binding sites on human lymphocytes have been studied using radioligand analyses. The process of [3H]spiperone binding to these sites can be explained by the model of ligand interaction with two independent binding sites (high-affinity site, KD1 = 3 nM, and low-affinity site, KD2 = 20 nM), thus confirming the heterogeneity of the sites on human lymphocytes.
authors.forename: I I
authors.initials: II
authors.lastname: Izumrudova
authors.forename: S V
authors.initials: SV
authors.lastname: Zaĭtsev
authors.forename: A A
authors.initials: AA
authors.lastname: Koshkin
authors.forename: N V
authors.initials: NV
authors.lastname: Porodenko
authors.forename: S D
authors.initials: SD
authors.lastname: Varfolomeev
mesh_terms: D014150:Antipsychotic Agents / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism*
chemical_list: D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; C028051:neuroleptic receptor
vernacular_title: Kineticheskie kharakteristiki tsentrov sviazyvaniia neĭroleptikov na limfotsitakh cheloveka.