Pulsed ultrasound and the hyperbarically exposed mouse fetus.
To enhance the likelihood of cavitation, pregnant mice were subjected to hyperbaric conditions and quickly returned to atmospheric pressure. Following this treatment, they were exposed to spatial average, pulse average intensities of 100 W/cm2 (2.2-MHz, 20-microseconds pulses with a duty cycle of 1/1000 or a temporal average spatial average intensity of 0.1 W/cm2). Fetal weights, deaths and malformations were scored. No statistically significant effects were observed in the offspring.
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Department of Electrical Engineering, University of Rochester, NY 14627.
Hoffman
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Norton
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Carstensen
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Cox
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Gates
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D000818:Animals; D001835:Body Weight; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005327:Fetal Resorption / Q000209:etiology; D005333:Fetus / Q000502:physiology*; D008098:Litter Size; D016015:Logistic Models; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011312:Pressure / Q000009:adverse effects; D011336:Probability; D013997:Time Factors; D014465:Ultrasonics / Q000009:adverse effects; D016216:Ultrasonography, Prenatal