Successful small-bowel/liver transplantation.
A patient with the short-gut syndrome and antithrombin III deficiency underwent small bowel and liver grafting a year ago. Transient, mild graft-versus-host disease and intestinal rejection occurred within 2 months of grafting and were easily managed. Parenteral nutrition was discontinued 8 weeks after surgery. The patient has maintained normal nutritional indices while on an unrestricted oral diet. Small-bowel/liver grafting is feasible for patients with the short-gut syndrome and associated liver disorders. Further experience is needed to determine the specific risks, benefits, and general applicability of this procedure.
Grant
D
D
Department of Medicine, University of Western Ontario, London, Canada.
Wall
W
W
Mimeault
R
R
Zhong
R
R
Ghent
C
C
Garcia
B
B
Stiller
C
C
Duff
J
J
D000328:Adult; D005223:Fats / Q000032:analysis; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000637:transplantation*; D008099:Liver / Q000378:metabolism; D016031:Liver Transplantation / Q000009:adverse effects; D008286:Malabsorption Syndromes / Q000601:surgery*; D015166:Monitoring, Immunologic; D011379:Prognosis; D012086:Reoperation; D012778:Short Bowel Syndrome / Q000601:surgery*; D013908:Thoracotomy / Q000009:adverse effects; D014994:Xylose / Q000652:urine
D005223:Fats; D014994:Xylose