Illustration of the effects of long-term xamoterol therapy on the time course of left ventricular pressure.
Detailed left ventricular haemodynamic investigations were performed in eight patients with New York Heart Association (NYHA) Class II heart failure, eight with NYHA Class III heart failure with an ejection fraction less than 35%, and six with severe heart failure. Xamoterol (200 mg b.d. for 3 months) caused a fall in left ventricular end-diastolic pressure, an increase in dP/dTmax and a shorter systole in all groups of patients.
van Mechelen
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Division of Cardiology, University of Louvain, Brussels, Belgium.
Ries
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Pouleur
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Rousseau
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MF
D000318:Adrenergic beta-Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002303:Cardiac Output, Low / Q000188:drug therapy; D006321:Heart / Q000187:drug effects*; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects*; D011412:Propanolamines / Q000494:pharmacology* / Q000627:therapeutic use; D017307:Xamoterol
D000318:Adrenergic beta-Agonists; D011412:Propanolamines; D017307:Xamoterol