A molecular genetic linkage map of mouse chromosome 2.
Interspecific backcross mice were used to create a molecular genetic linkage map of chromosome 2. Genomic DNAs from N2 progeny were subjected to Southern blot analysis using molecular probes that identified the Abl, Acra, Ass, C5, Cas-1, Fshb, Gcg, Hox-5.1, Jgf-1, Kras-3, Ltk, Pax-1, Prn-p, and Spna-2 loci; these loci were added to the 11 loci previously mapped to the distal region of chromosome 2 in the same interspecific backcross to generate a composite multilocus linkage map. Several loci mapped near, and may be the same as, known mutations. Comparisons between the mouse and the human genomes indicate that mouse chromosome 2 contains regions homologous to at least six human chromosomes. Mouse models for human diseases are discussed.
Siracusa
L D
LD
Mammalian Genetics Laboratory, NCI-Frederick Cancer Research Facility, Maryland 21701.
Silan
C M
CM
Justice
M J
MJ
Mercer
J A
JA
Bauskin
A R
AR
Ben-Neriah
Y
Y
Duboule
D
D
Hastie
N D
ND
Copeland
N G
NG
Jenkins
N A
NA
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D008817:Mice, Mutant Strains / Q000235:genetics; D009115:Muridae / Q000235:genetics*; D009857:Oncogenes; D012150:Polymorphism, Restriction Fragment Length; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity