Examination of the follicular maturation influencing effect of Clostilbegyt by endocrinous and electronic monitoring.
The follicle maturation influencing effect of Clostilbegyt (50 mg Clomiphene-citrat) has been examined in 30 women suffering from primary or secondary sterility. For monitoring follicular development a vaginal ultrasound scanner was used. The development of yellow body and its adequate function have been controlled with serum progesterone determination. In the first therapeutical cycle daily 1 tbl. Clostilbegyt was used from the 4th day of the menstruation in a five day period. In the next cycle daily 2 tbl. were administered similarly. If the therapy was unsuccessful, then 3 tbl. per day Clostilbegyt was used as treatment in the 3rd cycle. In the course of monitoring with vaginal ultrasound scanner successful ovulation induction has been proved in 80% of the Clostilbegyt treated cases (in 24 of 30 cases). During the examination period pregnancy occurred in 7 cases (29.2%). Vaginal ultrasound monitoring is recommended by the author for ovulation induction therapy.
Cseh
I
I
Department of Obstetrics and Gynaecology, Postgraduate Medical School, Budapest.
Perkedi
G
G
Drávucz
S
S
Gáti
I
I
D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005498:Follicular Phase / Q000187:drug effects*; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008991:Monitoring, Physiologic / Q000379:methods* / Q000592:standards; D010062:Ovulation Induction / Q000379:methods / Q000592:standards; D011374:Progesterone / Q000097:blood; D014463:Ultrasonography; D014621:Vagina / Q000000981:diagnostic imaging*
D006065:Gonadotropins, Pituitary; D002996:Clomiphene; D011374:Progesterone