CD4+ murine T cell clones that express high levels of immunoglobulin binding belong to the interleukin 4-producing T helper cell type 2 subset.
A panel of 20 murine CD4+ clones was examined for the presence of surface membrane receptors for IgA, IgM, IgD, IgE, and IgG. High level expression of multiple Fc receptors (FcRs) was found on all Th2 clones. FcR expression was low or undetected on the Th1 clones. The preferential expression of FcR on activated Th2 cells suggests potential mechanisms for immunoregulatory interactions with B cells.
Sandor
M
M
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
Gajewski
T
T
Thorson
J
J
Kemp
J D
JD
Fitch
F W
FW
Lynch
R G
RG
D000818:Animals; D015704:CD4 Antigens; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002999:Clone Cells; D007136:Immunoglobulins / Q000378:metabolism*; D015847:Interleukin-4 / Q000096:biosynthesis*; D051379:Mice; D011961:Receptors, Fc / Q000096:biosynthesis* / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism
D015704:CD4 Antigens; D007136:Immunoglobulins; D011961:Receptors, Fc; D015847:Interleukin-4