title: Cardiopulmonary bypass, profound hypothermia, and circulatory arrest for neurosurgery.
abstract: Six female and 4 male patients (age, 23 to 75 years) underwent operation for difficult intracranial lesions. Preoperative diagnoses included four giant intracranial aneurysms, three base of skull glomus jugulare tumors, two arteriovenous malformations, and one cerebellar hemangioblastoma. All lesions were inoperable or nearly so by standard neurosurgical techniques. All patients were placed on total bypass via groin cannulations. Bypass times ranged from 111 to 269 minutes (mean, 174 minutes) with cooling times of 26 to 83 minutes (mean, 48 minutes) and warming times of 68 to 110 minutes (mean, 83 minutes). Circulatory arrest times ranged from 1.25 to 60 minutes with 1 patient not requiring arrest. The lowest core temperatures recorded varied from 8.4 degrees to 13.7 degrees C. There was one postoperative death and one major complication, both in patients with arteriovenous malformations. Eight patients (80%) have achieved an excellent result. Profound hypothermia with the option of circulatory arrest and exsanguination has been an indispensable adjunct to the safe management of intracranial aneurysm, glomus jugulare tumor, and hemangioblastoma.
authors.affiliation: Department of Surgery, Saint Joseph Hospital, Denver, Colorado.
authors.forename: M D
authors.initials: MD
authors.lastname: Williams
authors.forename: W G
authors.initials: WG
authors.lastname: Rainer
authors.forename: H G
authors.initials: HG
authors.lastname: Fieger
authors.forename: I P
authors.initials: IP
authors.lastname: Murray
authors.forename: M L
authors.initials: ML
authors.lastname: Sanchez
mesh_terms: D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass; D005260:Female; D005925:Glomus Jugulare Tumor / Q000601:surgery*; D006324:Heart Arrest, Induced; D006801:Humans; D007036:Hypothermia, Induced; D002532:Intracranial Aneurysm / Q000601:surgery*; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D013997:Time Factors