Signal transducing GTP-binding proteins in olfaction.
1. Several members of the family of heterotrimeric signal transducing GTP-binding proteins have been identified in the olfactory epithelium of vertebrates by biochemical and molecular cloning techniques. 2. Biochemical and electrophysiological evidence indicates that one or more GTP-binding proteins mediate many olfactory responses by coupling stimulus receptors to second messenger systems. 3. Although GTP-binding proteins may function in additional transduction events, a novel GTP-binding protein, expressed only in olfactory neurons, may mediate stimulus activation of adenylate cyclase in olfactory cilia.
Bruch
R C
RC
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208.
D000262:Adenylyl Cyclases / Q000502:physiology; D000818:Animals; D004848:Epithelium / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D009831:Olfactory Mucosa / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D012903:Smell / Q000502:physiology*
D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases