title: Genes encoding the beta-chains of HLA-DR7 and HLA-DQw2 define major susceptibility determinants for idiopathic nephrotic syndrome.
abstract: 1. We have investigated the frequencies of the major histocompatibility complex class II alleles by restriction fragment length polymorphism analysis, using DR, DQ and DP complementary DNA probes, in 40 Caucasoid steroid-sensitive nephrotic children. 2. A significant association with HLA-DR7 was demonstrated (P = 2 x 10(-5); aetiological fraction 0.6). The DQB1 gene of HLA-DQw2 was present in 83% of our patients (P = 2 x 10(-4); aetiological fraction 0.7). We present evidence that it contributes a second susceptibility allele. 3. A weak association between the uncommon HLA-DP-Cp63 allele and the disease was also observed. 4. Our data suggest that the immune events in steroid-sensitive nephrotic syndrome are defined by a particular immunogenetic background involving the beta-chain genes of HLA-DR7 and HLA-DQw2.
authors.affiliation: Evelina Children's Department, United Medical School, St Thomas Hospital, London.
authors.forename: A G
authors.initials: AG
authors.lastname: Clark
authors.forename: R W
authors.initials: RW
authors.lastname: Vaughan
authors.forename: H A
authors.initials: HA
authors.lastname: Stephens
authors.forename: C
authors.initials: C
authors.lastname: Chantler
authors.forename: D G
authors.initials: DG
authors.lastname: Williams
authors.forename: K I
authors.initials: KI
authors.lastname: Welsh
mesh_terms: D000293:Adolescent; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D015342:DNA Probes; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics*; D015809:HLA-DR7 Antigen / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D009402:Nephrosis, Lipoid / Q000235:genetics*; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D015342:DNA Probes; D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; D015809:HLA-DR7 Antigen