Effects of a single-dose pretreatment with captopril on the immediate response to nasal challenge with allergen.
We performed a double-blind, placebo-controlled, crossover study using 12 subjects to determine the effects of a single 50-mg dose of captopril on the response to nasal challenge with increasing doses of allergen. Levels of kinins, histamine and N-alpha-p-tosyl-L-arginine methyl ester (TAME)-esterase activity were measured in nasal lavages, and symptom scores and the number of sneezes were recorded. Captopril had no significant effects on histamine, TAME-esterase, sneezing or symptom scores. Peak postchallenge kinin levels, however, were significantly elevated (p less than 0.05) compared to placebo, while an increase in the magnitude of the dose-response curve was of marginal significance (p = 0.058). Thus, captopril causes increases in the kinin levels in nasal secretions during the allergic response. If increased kinin levels persist or worsen with chronic therapy, it is possible that they could exacerbate allergic symptoms during repeated seasonal exposure.
Proud
D
D
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md.
Naclerio
R M
RM
Meyers
D A
DA
Kagey-Sobotka
A
A
Lichtenstein
L M
LM
Valentine
M D
MD
D000328:Adult; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006632:Histamine / Q000032:analysis; D006801:Humans; D007705:Kinins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism; D010447:Peptide Hydrolases / Q000032:analysis; D007703:Peptidyl-Dipeptidase A / Q000502:physiology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000378:metabolism*
D007705:Kinins; D006632:Histamine; D002216:Captopril; D010447:Peptide Hydrolases; C023073:tosylarginine methyl ester hydrolase; D007703:Peptidyl-Dipeptidase A