Retrospective analysis of posttransplantation diabetes mellitus in black renal allograft recipients.
OBJECTIVE
To study the incidence, outcome, and possible etiopathogenic factors involved in posttransplantation diabetes mellitus in cyclosporine-treated black renal allograft recipients.


METHODS
One hundred thirty-eight nondiabetic black renal transplant recipients whose grafts survived greater than 1 yr were studied retrospectively.


RESULTS
Twenty-eight (20.3%) patients developed posttransplantation diabetes mellitus, 46 and 75% were diagnosed by 6- and 12-mo posttransplantation, respectively, and 46% were insulin dependent. Diabetes was more frequently encountered in older recipients and recipients of cadaveric kidneys but was independent of sex, number of transplants, incidence of acute rejection, percentage of body weight gain, steroid or cyclosporine dose, and use of beta-blockers and/or diuretics. Renal function was similar in the diabetic group compared with the control group. Actuarial 5-yr graft survival was 82% in the diabetic cohort compared with 78% in the control group, with chronic rejection accounting for all graft losses within the diabetic group.


CONCLUSIONS
Twenty percent of black cyclosporine-treated renal allograft recipients developed diabetes mellitus in the posttransplantation period. However, its presence did not appear to influence intermediate-term graft or patient survival.
Sumrani
N B
NB
Department of Surgery and Medicine, State University of New York Health Science Center, Brooklyn 11203.
Delaney
V
V
Daskalakis
P
P
Davis
R
R
Friedman
E A
EA
Hong
J H
JH
Sommer
B G
BG
D000328:Adult; D044383:Black People; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000209:etiology*; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000502:physiology*; D011241:Prednisone / Q000627:therapeutic use; D012189:Retrospective Studies; D014184:Transplantation, Homologous; D014481:United States; D014511:Uremia / Q000601:surgery; D001741:Black or African American
D016572:Cyclosporine; D011241:Prednisone