title: The relaxin gene is located on chromosome 19 in the mouse.
abstract: Relaxin is a polypeptide hormone that exerts a variety of physiological effects during pregnancy. To investigate the possibility that known genetic mutations affecting aspects of reproductive physiology result in alterations in the structure or production of relaxin, we have determined the chromosomal location of the mouse gene. The finding of a BamHI restriction fragment length polymorphism in AKR mice enabled us to use recombinant inbred strains to make an assignment to chromosome 19. This was confirmed by Southern analysis of DNA from microcell hybrids.
authors.affiliation: Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: K J
authors.initials: KJ
authors.lastname: Fowler
authors.forename: W M
authors.initials: WM
authors.lastname: Clouston
authors.forename: R E
authors.initials: RE
authors.lastname: Fournier
authors.forename: B A
authors.initials: BA
authors.lastname: Evans
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002875:Chromosomes; D004247:DNA / Q000235:genetics; D008040:Genetic Linkage; D006822:Hybrid Cells; D051379:Mice; D008815:Mice, Inbred Strains; D011110:Polymorphism, Genetic; D012065:Relaxin / Q000235:genetics*; D013045:Species Specificity
chemical_list: D012065:Relaxin; D004247:DNA