Effect of Nilzan and albendazole on the absorptive surfaces of Haemonchus contortus (Nematoda)--a histoenzymic study.
Haemonchus contortus, incubated in 10 micrograms/ml and 50 micrograms/ml concentrations of Nilzan and albendazole in Tyrode solution were stained for histoenzymatic demonstration of various phosphatases, oxido-reductases and esterases. The intestine showed major alterations after drug treatments. The alkaline phosphatases (AkPase), adenosine triphosphatase (ATPase), glucose-6-phosphatase, succinic dehydrogenase (SDH), glutamate dehydrogenase (GDH), reduced nicotinamide adenine dinucleotide phosphate diaphorase and reduced nicotinamide adenine dinucleotide diaphorase showed a decreased activity in intestine after Nilzan treatment, whereas lactic dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PD) and monoamine oxidase resisted increased reaction. The albendazole treatment resulted in altered distribution pattern of the AkPase, ATPase, SDH, and GDH; while LDH, G-6-PD, and non-specific esterases exhibited slightly enhanced activity in the epithelium. The functional significance of these changes has been fully discussed.
Kaur
M
M
Department of Zoology, Punjab Argricultural University, Ludhiana, India.
Sood
M L
ML
D000042:Absorption; D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D004338:Drug Combinations; D004950:Esterases / Q000032:analysis; D005260:Female; D006189:Haemonchus / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010088:Oxidoreductases / Q000032:analysis; D010097:Oxyclozanide / Q000494:pharmacology*; D010744:Phosphoric Monoester Hydrolases / Q000032:analysis; D013773:Tetramisole / Q000494:pharmacology*
D000969:Antinematodal Agents; D004338:Drug Combinations; D010097:Oxyclozanide; D013773:Tetramisole; D010088:Oxidoreductases; D004950:Esterases; D010744:Phosphoric Monoester Hydrolases; D015766:Albendazole