Antibiotic prophylaxis in ear, nose and throat surgery: a comparison of a single preoperative dose with three peri-operative doses of ceftazidime.
An open prospective randomized trial was conducted in three Italian ear, nose and throat (ENT) surgery departments on 120 patients aged 10 to 84 years, to compare a single pre-operative dose vs. three peri-operative doses of ceftazidime in surgical prophylaxis. Sixty patients in group I received 1 g ceftazidime intramuscularly (im) or intravenously (iv) 1 h before surgery, and 60 in group II received three 1 g doses of ceftazidime, im or iv, 1 h before, and 6 and 12 h after surgery. Post-operative infections were observed in six group I patients (10.1%) and seven group II patients (11.6%). All infections arose in patients who had undergone 'moderate-risk' (6.7%) or 'high-risk' surgery (30.5%). We conclude that a single pre-operative 1 g dose of ceftazidime is as efficacious as multiple peri-operative doses in the prophylaxis of infectious complications following this type of surgery.
Marcucci
L
L
ENT Department, Hospital of Viterbo, Italy.
Vellucci
A
A
Miani
P
P
Pallestrini
E
E
Garaventa
G
G
Marasca
M
M
Piemonte
M
M
Panebianco
R
R
Benedetti
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002442:Ceftazidime / Q000008:administration & dosage* / Q000627:therapeutic use; D003428:Cross Infection / Q000517:prevention & control; D005260:Female; D006801:Humans; D017053:Infection Control; D007239:Infections / Q000453:epidemiology; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic
D002442:Ceftazidime