title: Bradykinin inhibits rat myometrial adenylate cyclase activity via a high-affinity receptor.
abstract: Bradykinin (BK) which contracts the rat uterus inhibited at subnanomolar concentrations rat myometrial adenylate cyclase stimulated by NaF or guanyl nucleotides by about 40%. The effect was maximal at about 10 to 100 pM. At a higher concentration (100 nM), bradykinin was ineffective. Together with recently presented results these data suggest that in rat myometrium the adenylate cyclase may be coupled by a G12/G13-type G-protein to a high-affinity BK receptor.
authors.affiliation: Department of Biology, Friedrich Schiller University, Jena.
authors.forename: C
authors.initials: C
authors.lastname: Liebmann
authors.forename: S
authors.initials: S
authors.lastname: Reissmann
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D005260:Female; D009215:Myometrium / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism; D012969:Sodium Fluoride / Q000494:pharmacology
chemical_list: D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter; D012969:Sodium Fluoride; D000262:Adenylyl Cyclases; D001920:Bradykinin