Human T-cell lymphotropic virus type I infection and pregnancy: a case-control study and 12-month follow-up of 135 women and their infants.
Human T-cell lymphotropic virus type I (HTLV-I) infection is common in Gabon, but its influence on pregnancy is unknown. A single case of acute T-cell leukemia in a pregnant woman has been reported in the literature, but, as far as we know, we present the first case-control study analyzing the relationship between HTLV-I seropositivity and the course and outcome of pregnancy. The study concerned 45 HTLV-I seropositive pregnant women matched with 90 seronegative pregnant women. None has clinical features of HTLV-I infection during pregnancy or during the year after delivery. HTLV-I seropositivity did not significantly affect the course or outcome of pregnancy. After losing maternal antibodies to HTLV-I, none of the infants had seroconversion to HTLV-I 1 year after birth. Filaria infection was correlated with HTLV-I seropositivity, but confounding factors may account for this observation.
Ville
Y
Y
Centre International de Recherche Medicale, Franceville, Gabon.
Delaporte
E
E
Peeters
M
M
Leruez
M
M
Glowaczower
E
E
Fernandez
H
H
D000328:Adult; D000349:Africa; D001034:Apgar Score; D001772:Blood Cell Count; D001835:Body Weight; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D015490:HTLV-I Infections / Q000150:complications*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007223:Infant; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011256:Pregnancy Outcome; D012725:Sexual Behavior