title: Inhibition of electron transport of rat liver mitochondria by unnatural (-)-antimycin A3.
abstract: The inhibition of electron transport by unnatural (-)-antimycin A3 was examined with rat liver mitochondria and compared with that of natural (+)-antimycin A3. (-)-Antimycin A3 inhibited respiration about 1/100th as strongly as natural (+)-antimycin A3. (-)-Antimycin A3 binding to the cytochrome bc1 complex did not seem to induce a conformational change in this proteinous complex. The binding site of (-)-antimycin A3 was probably the same as that of (+)-antimycin A3 (at the Qi center). However, the mode of interaction with the Qi center by (-)-antimycin A3 and (+)-antimycin A3 was somewhat different.
authors.affiliation: Department of Agricultural Chemistry, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Miyoshi
authors.forename: H
authors.initials: H
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Oritani
authors.forename: I
authors.initials: I
authors.lastname: Saitoh
authors.forename: H
authors.initials: H
authors.lastname: Iwamura
mesh_terms: D000818:Animals; D000968:Antimycin A / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D003573:Cytochrome b Group / Q000378:metabolism; D004579:Electron Transport; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D013057:Spectrum Analysis; D013237:Stereoisomerism; D013386:Succinates / Q000494:pharmacology; D019802:Succinic Acid
chemical_list: D003573:Cytochrome b Group; D013386:Succinates; D000968:Antimycin A; D019802:Succinic Acid