Neurohumoral pathways mediating stress-induced inhibition of gastric acid secretion in rats.
In awake rats, physical restraint inhibited pentagastrin-stimulated gastric acid secretion by more than 50%. This inhibitory effect was abolished by either ganglionic or noradrenergic blockade. Adrenalectomy, as well as pretreatment with a vasopressin V1-receptor antagonist, significantly attenuated the gastric inhibitory effect in response to stress. In contrast, neither truncal vagotomy nor hypophysectomy or opiate blockade prevented stress-induced inhibition of gastric acid secretion. These findings indicate that stress-induced inhibition of gastric acid secretion in rats is mediated by autonomic, noradrenergic efferents as well as by adrenal and vasopressin-dependent pathways. Vagal efferents, opiate pathways, and the pituitary gland do not seem to be involved.
Lenz
H J
HJ
Department of Medicine, University of Hamburg, West Germany.
Drüge
G
G
D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology; D001950:Bretylium Tosylate / Q000494:pharmacology; D002714:Chlorisondamine / Q000494:pharmacology; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D005728:Ganglia, Sympathetic / Q000502:physiology; D005744:Gastric Acid / Q000378:metabolism*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009434:Neural Pathways / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D010418:Pentagastrin / Q000494:pharmacology; D010902:Pituitary Gland / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*; D014630:Vagus Nerve / Q000502:physiology
D018377:Neurotransmitter Agents; D001127:Arginine Vasopressin; D009270:Naloxone; C028888:argipressin, deaminopenicillamine(1)-O-methyl-Tyr(2)-; D001950:Bretylium Tosylate; D003346:Corticotropin-Releasing Hormone; D010418:Pentagastrin; D002714:Chlorisondamine