Fluprazine hydrochloride: no influence on the odor detection performance of male rats.
Fluprazine hydrochloride (DU 27716) decreases copulatory and offensive attack behaviors of male rats and increases their latency to locate buried food in an open field. Since such behaviors are mediated to some degree by the olfactory system, several investigators have hypothesized that this drug may produce an overall impairment in olfactory sensitivity. To test this hypothesis, the influences of five doses of fluprazine hydrochloride (1.0, 2.5, 5.0, 7.5 and 10.0 mg/kg IP) on the odor detection performance of 12 adult male Long Evans rats was assessed, relative to saline, using high precision olfactometry and a go/no-go operant odor detection task. Treatments were administered every 3rd day in counterbalanced order, with the drug or saline injections occurring 30 minutes before the 260-trial test sessions. No significant influence of fluprazine was observed on odor detection performance, as measured by the nonparametric signal detection sensitivity index SI and the percentage of correct trials. These results indicate that fluprazine does not induce generalized olfactory impairment.
Doty
R L
RL
Smell and Taste Center, Hospital of the University of Pennsylvania, Philadelphia 19104.
Li
C
C
Risser
J M
JM
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002490:Central Nervous System / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009812:Odorants; D009833:Olfactory Pathways / Q000187:drug effects / Q000502:physiology*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D012684:Sensory Thresholds
D014151:Anti-Anxiety Agents; D010879:Piperazines; C035521:fluprazine