[Histochemical changes of islet cells of Langerhans after hepatectomy and effect of glucagon and insulin].
It has been made by a number of studies that after hepatic resection, portal factors such as insulin and glucagon play an important role in liver regeneration. We have reported hypertrophy of Langerhans islands of dogs after partial hepatectomy. In the present study we attempted to clarify the mechanism of this hypertrophy. In a control group, a forty-percent hepatectomy was carried out. One and four weeks after surgery, 0.5g/kg of glucose was administered intravenously followed by a blood sampling from the portal vein to measure the changes of glucose, insulin and glucagon respectively. In addition area changes of the islets of Langerhans after the operation were measured with PAP technique. In a GI group, the same experiment as in the control group was done and 1mg of glucagon and 2IU/kg of insulin were administered every morning after the operation. The following results were obtained. In the GI group, there were no decrease in portal plasma insulin level and no enlargement of the sizes of the islets four weeks after surgery.
Sudo
T
T
Second Department of Surgery Kinki University School of Medicine, Osakasayama, Japan.
Kanazawa
H
H
Miyamoto
M
M
Yasuda
C
C
Uchida
T
T
Kawamura
M
M
Kuyama
T
T
D000818:Animals; D004285:Dogs; D005934:Glucagon / Q000494:pharmacology*; D006498:Hepatectomy; D007328:Insulin / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000166:cytology*
D007328:Insulin; D005934:Glucagon