[Neurotransmitters of penile erection other than vasoactive intestinal polypeptide. Physiologic data and therapeutic consequences].
It has been suggested that vasoactive intestinal polypeptide (VIP) may be involved in the nervous control of penile tumescence and erection. VIP ergic nerves are present in the human penis, especially around the prudendal arteries and the corpus cavernosum. However, we have shown that VIP is unlikely to be non-adrenergic, non-cholinergic inhibitory transmitter for penile erection. The aim of this presentation is also to analyse other neurotransmitters of penile erection. This included discussion on: 1. motor neurotransmission; 2. non-adrenergic, non-cholinergic inhibitory transmission; 3. endogenously formed relaxants in the corpus cavernosum; 4. involvement of endothelium-derived relaxing factor(s) and; 5. role of prostanoids in penile erection and others.
Adaikan
P G
PG
Département d'Obstétrique et Gynécologie, National University of Singapore, National University Hospital.
Lau
L C
LC
Vasatha
K S
KS
Susheela
K
K
Ratnam
S S
SS
D000527:Alprostadil / Q000502:physiology; D007172:Erectile Dysfunction / Q000188:drug therapy; D006801:Humans; D008297:Male; D018377:Neurotransmitter Agents / Q000502:physiology*; D010208:Papaverine / Q000627:therapeutic use; D010410:Penile Erection / Q000502:physiology*; D011317:Priapism / Q000139:chemically induced; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D014196:Trazodone / Q000009:adverse effects; D014660:Vasoactive Intestinal Peptide / Q000502:physiology*; D015016:Yohimbine / Q000627:therapeutic use
D018377:Neurotransmitter Agents; D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; D014660:Vasoactive Intestinal Peptide; D010208:Papaverine; D000527:Alprostadil; D014196:Trazodone
Les neurotransmetteurs de l'érection autres que le vasoactivité-intestinal-polypeptide. Données physiologiques et conséquences thérapeutiques.