A prospective study of human papillomavirus infection of the cervix.
In a prospective study 42 women, diagnosed as having low grade cervical intraepithelial neoplasia (CIN), made a total of 281 clinic visits over a 45 month period. At each visit, they were subjected to cytological and colposcopical examination and samples were taken for human papillomavirus (HPV) DNA hybridization studies and for the detection of non-HPV infections. HPV types 16 and/or 18 were found in 25% of all the samples tested and these virus types were detected in five of six (83%) women whose lesions progressed compared to seven of 14 (50%) of those whose lesions regressed. The presence of HPV DNA was not a good prognostic indicator of progression since half of those whose disease regressed also harboured these viruses at some time. The recording of non-HPV infections almost 10 times more often in the women whose disease regressed than in those whose disease progressed could probably be accounted for by the former having a larger number of follow-up visits. Nevertheless, the significance of non-HPV infections also remains unclear.
Byrne
M A
MA
Jefferiss Wing, St Mary's Hospital, London.
Parry
G C
GC
Morse
A
A
Taylor-Robinson
D
D
Malcolm
A D
AD
Coleman
D V
DV
D001424:Bacterial Infections / Q000150:complications; D002181:Candidiasis, Vulvovaginal / Q000150:complications; D002278:Carcinoma in Situ / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D003218:Condylomata Acuminata / Q000150:complications / Q000382:microbiology; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006558:Herpes Genitalis / Q000150:complications; D006801:Humans; D009361:Neoplasm Invasiveness; D027383:Papillomaviridae / Q000302:isolation & purification*; D011446:Prospective Studies; D014247:Trichomonas Vaginitis / Q000150:complications; D014412:Tumor Virus Infections / Q000150:complications* / Q000382:microbiology; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D002575:Uterine Cervicitis / Q000150:complications*
D015344:DNA Probes, HPV; D004279:DNA, Viral