title: [The mechanisms of the disorder of calcium homeostasis in terminal kidney failure and the allotransplantation of a cadaver kidney].
abstract: Overall 34 patients with terminal renal failure (TRF) and 81 recipients of the allotransplanted cadaveric kidney (ACK) were examined. It has been established in in-vitro experiments with modulated by additions of EDTA to the plasma and CaCl2 hypo- and hypercalcemia that the magnitude of bound calcium (standardized at the concentration of ionized calcium-Ca++1 mmol/l) decreased in the blood plasma in 65 and 61% of cases. Besides protein-bound calcium dropped in 94 and 91% of cases; the total buffer capacity of the plasma and buffer capacity of proteins fell in 59 and 87% of cases in TRF and ACK, respectively. The rise of the Ca++ content on an empty stomach seen in 21 out of 99 patients with TRF and in 42 out of 98 recipients of the ACK was caused by a decrease of calcium binding in the blood plasma, not made for by the fall of calcium supply to the blood because of "tertiary" hyperparathyroidism. Hypocalcemia detected in 38% of TRF patients was consequence to the rise of calcium binding not made for by the increased calcium supply to the blood provoked by bone resistance to parathyroid hormone.
authors.forename: I P
authors.initials: IP
authors.lastname: Ermakova
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Sokolova
authors.forename: I A
authors.initials: IA
authors.lastname: Pronchenko
authors.forename: L S
authors.initials: LS
authors.lastname: Biriukova
authors.forename: A E
authors.initials: AE
authors.lastname: Ermolenko
authors.forename: E R
authors.initials: ER
authors.lastname: Levitskiĭ
mesh_terms: D002021:Buffers; D002102:Cadaver; D002118:Calcium / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000097:blood; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D016030:Kidney Transplantation; D010949:Plasma / Q000378:metabolism; D006435:Renal Dialysis; D014184:Transplantation, Homologous
chemical_list: D002021:Buffers; D002135:Calcium-Binding Proteins; D002118:Calcium
vernacular_title: Mekhanizmy narusheniia gomeostaza kal'tsiia pri terminal'noĭ pochechnoĭ nedostatochnosti i allotransplantatsii trupnoĭ pochki.