title: [Multicenter study of the effectiveness and tolerance of clotiazepam in cardiology].
abstract: In a phase IV study with clotiazepam 9 cardiologists were involved to treat 86 patients (52 female, 32 male, mean age 51 years) effected by cardiovascular diseases and anxiety. The dosage was 5-10 mg TID, and the treatment lasted for 3 weeks. Variations of the dosage were requested in 21% of patients and generally at the 2nd week of treatment. The safety of clotiazepam was good: only in the 14% of patients side-effects were observed (especially drowsiness 9.3% and asthenia 2.3%). Clotiazepam was judged to be effective in 75% of patients. The Hamilton psychiatric rating scale for anxiety showed a progressive decrease both of the total score and of the scores of every item; the cardiovascular symptoms particularly improved at both the controls.
authors.affiliation: Divisione di Cardiologia, Policlinico Consorziale, Bari.
authors.forename: L
authors.initials: L
authors.lastname: Colonna
authors.forename: F
authors.initials: F
authors.lastname: Cozzi
authors.forename: F
authors.initials: F
authors.lastname: Del Citerna
authors.forename: A
authors.initials: A
authors.lastname: Di Benedetto
authors.forename: O
authors.initials: O
authors.lastname: De Divitiis
authors.forename: F
authors.initials: F
authors.lastname: Furlanello
authors.forename: F
authors.initials: F
authors.lastname: Milazzotto
authors.forename: M
authors.initials: M
authors.lastname: Pittalis
authors.forename: A
authors.initials: A
authors.lastname: Taccola
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000150:complications / Q000188:drug therapy*; D001381:Azepines / Q000008:administration & dosage / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000523:psychology*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011569:Psychiatric Status Rating Scales
chemical_list: D001381:Azepines
vernacular_title: Studio policentrico sull'efficacia e tollerabilità del clotiazepam in cardiologia.