Effects of defective interfering viruses on virus replication and pathogenesis in vitro and in vivo.
DI viruses and defective viruses generally are widespread in nature. Laboratory studies show that they can sometimes exert powerful disease-modulating effects (either attenuation or intensification of symptoms). Their role in nature remains largely unexplored, despite recent suggestive evidence for their importance in a number of systems.
Roux
L
L
Département de Microbiologie, CMU, Geneva, Switzerland.
Simon
A E
AE
Holland
J J
JJ
D000818:Animals; D003673:Defective Viruses / Q000502:physiology*; D006801:Humans; D010944:Plants / Q000382:microbiology; D018406:Virus Physiological Phenomena; D014779:Virus Replication; D014780:Viruses / Q000235:genetics / Q000472:pathogenicity