title: Synthesis of C-(beta-D-glycosyl) analogues of 3-deoxy-D-manno-2-octulosonic acid (Kdo) as potential inhibitors of CMP-Kdo synthetase.
abstract: Eight C-(beta-D-glycosyl) analogues (14-21) of Kdo (3-deoxy-D-manno-2-octulosonic acid) were obtained from isopropylidene-protected ester precursors and tested in vitro for their inhibitory activity on CMP-Kdo synthetase. None had more than minor inhibitory activity.
authors.affiliation: Department of Organic Pharmaceutical Chemistry, University of Uppsala, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Wåglund
authors.forename: K
authors.initials: K
authors.lastname: Luthman
authors.forename: M
authors.initials: M
authors.lastname: Orbe
authors.forename: A
authors.initials: A
authors.lastname: Claesson
mesh_terms: D002236:Carbohydrate Conformation; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D015394:Molecular Structure; D009713:Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D013400:Sugar Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D013400:Sugar Acids; C002532:2-keto-3-deoxyoctonate; D009713:Nucleotidyltransferases; C028984:3-deoxy-manno-octulosonate cytidyltransferase