title: [Long-term surgical results of microprolactinomas].
abstract: Sixty three patients with microprolactinoma were studied by long-term follow-up after surgical cure. Postoperative normalization of prolactin (PRL) was seen in 38 (60%) of the total 63 cases, and hyperprolactinemia recurred in 5 (13%) during the follow-up period. Spontaneous restoration of menstruation occurred in 45 (71%), and, in 41 (65%), regular menstrual cycle as continuing at the time of the last follow-up. 34 (72%) of 47 patients who wanted children became pregnant, and 31 of these had a subsequent successful delivery. Clinical cure by surgical treatment alone, followed by spontaneous restoration of menstruation and continuation of regular cycle during the follow-up period after pregnancy and delivery was seen in 41 (65%) of the total cases. From these results, it was concluded that transsphenoidal surgery should be the treatment of first choice for microprolactinoma when complete cure is required.
authors.affiliation: Department of Neurosurgery, Hiroshima University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Hirohata
authors.forename: T
authors.initials: T
authors.lastname: Uozumi
authors.forename: K
authors.initials: K
authors.lastname: Mukada
authors.forename: K
authors.initials: K
authors.lastname: Arita
authors.forename: K
authors.initials: K
authors.lastname: Kurisu
authors.forename: T
authors.initials: T
authors.lastname: Yano
authors.forename: A
authors.initials: A
authors.lastname: Takechi
authors.forename: J
authors.initials: J
authors.lastname: Onda
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008598:Menstruation; D010060:Ovulation; D010902:Pituitary Gland / Q000503:physiopathology; D010911:Pituitary Neoplasms / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D011379:Prognosis; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000503:physiopathology / Q000601:surgery*
chemical_list: D011388:Prolactin