Anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, Papio papio.
Abecarnil (ZK 112119; isopropyl-6-benzyloxy-4-methoxymethyl-beta-carboxylate) is a metabolically stable beta-carboline derivative with potent anxiolytic and few sedative and ataxic effects in rodents. The anticonvulsant and muscle relaxant actions of abecarnil have been evaluated in mice, rats, gerbils and baboons. Abecarnil raised the threshold for tonic electroconvulsions in mice after corneal but not after auricular application, had no effect on maximal electroshock-induced tonic convulsions triggered by either method, protected mice against the tonic hindlimb extension in PTZ-, picrotoxin- and 3-mercaptopropionate-induced seizures and blocked clonus after PTZ, DMCM (methyl-4-ethyl-6,7-dimethoxy-9H-pyrido-(3,4-b)-indol-3-carboxylate) and 3-mercaptopropionate. Abecarnil had no effect on convulsions induced by bicuculline and strychnine. Furthermore, abecarnil blocked kindled seizures after chronic administration of PTZ and FG 7142 (beta-carboline-3-carboxylic acid methylamide) and protected mice and rats against limbic convulsions induced by pilocarpine. Severity and afterdischarge duration of amygdala-kindled seizures were reduced in rats treated with abecarnil. Abecarnil also antagonized selectively convulsions induced by i.c.v. administration of kainate, but not those triggered by N-methyl-D-aspartate or quisqualate. In genetic models of reflex epilepsy, abecarnil was effective against sound-induced convulsions in DBA/2 mice, against air blast-induced generalized seizures in gerbils and against myoclonus in baboons Papio papio. The anticonvulsant effect of abecornil in a PTZ seizure model in mice was potentiated by ethosuximide, whereas no significant potentiation was found with diazepam, clonazepam, diphenylhydantoin, carbamazepine and phenobarbital. Electromyographic monitoring in a etorphine model of muscle rigidity in rats showed no or little muscle relaxant effect of abecarnil.(ABSTRACT TRUNCATED AT 250 WORDS)
Turski
L
L
Research Laboratories of Schering AG, Berlin/West, Federal Republic of Germany.
Stephens
D N
DN
Jensen
L H
LH
Petersen
E N
EN
Meldrum
B S
BS
Patel
S
S
Hansen
J B
JB
Löscher
W
W
Schneider
H H
HH
Schmiechen
R
R
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D004576:Electromyography; D005048:Etorphine / Q000494:pharmacology; D005260:Female; D005849:Gerbillinae; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D010215:Papio; D051381:Rats; D011919:Rats, Inbred Strains
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002243:Carbolines; D005048:Etorphine; C062769:abecarnil; D003975:Diazepam