[Current findings in the regulation of formation of corticoliberin, pro-opiomelanocortin and ACTH as well as the efficacy of these compounds].
A survey is given on the regulation of the formation of corticoliberin and of pro-opiomelanocortin and of ACTH, respectively, and on the significance of these compounds. The formation of pro-opiomelanocortin is furthered by corticoliberin, vasopressin, oxytocin and angiotensin II. Receptors for the binding of corticoliberin appear in numerous parts of the central nervous system. In various diseases the content of corticoliberin in the plasma and in certain tissues is changed. The inhibition of the ACTH secretion by glucocorticosteroids takes place via a decrease of the formation of corticoliberin and by a reduction of the equipment of the corticotrophic cells with receptors for its binding. The secretion of corticoliberin and of ACTH, respectively, is increased by loads, by hypoglycaemia, by blood losses, by hypoxia and by infections. In the glucocorticosteroid receptors there are 2 types with different affinity to cortisol and corticosterone.
Kolb
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Wissenschaftsbereich Tierbiochemie, Karl-Marx-Universität Leipzig.
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis* / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D003346:Corticotropin-Releasing Hormone / Q000096:biosynthesis* / Q000494:pharmacology; D006470:Hemorrhage / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism; D007239:Infections / Q000378:metabolism; D010121:Oxytocin / Q000494:pharmacology; D011333:Pro-Opiomelanocortin / Q000096:biosynthesis* / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000187:drug effects; D014667:Vasopressins / Q000494:pharmacology
D011956:Receptors, Cell Surface; D014667:Vasopressins; D000804:Angiotensin II; D010121:Oxytocin; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone
Neuere Erkenntnisse zur Regulation der Bildung von Corticoliberin, Proopiomelanocortin und ACTH sowie zur Wirksamkeit dieser Verbindungen.