Albumin--vitamin D-binding protein haplotypes in Asian-Pacific populations.
We have determined the various haplotypic combinations between alleles as well as restriction fragment length polymorphisms of two linked genetic markers, albumin and vitamin D-binding protein or group-specific component, in a number of Asian-Pacific populations. Using the partial maximum likelihood method, we constructed a phylogenetic network from the haplotype frequencies to assess relationships among the populations sampled. No systematic linkage disequilibrium was detected between most of the combinations, suggesting a lack of operation of any selection pressure at the two loci. The phylogenetic analysis confirmed the known interrelationships among various populations in the Asian-Pacific region. The Australian aborigines clustered closely with the non-Austronesian-speaking highlanders from Papua New Guinea, as expected. Similarly, the Austronesian-speaking Polynesians, Micronesians, and the Southeast Asians branched off together as a separate group. The position of the Austronesian-speaking Tolais from New Britain with respect to other populations from the Southwest Pacific was anomalous. The Tolais revealed a strong affinity with the Australian aborigines, which is inexplicable. The populations from China formed a tight cluster with other populations from the Asian-Pacific region. Genetic interrelationships of these populations with the white Australians were remote, which is in accordance with the known affinities of various human racial groups.
Chen
L Z
LZ
John Curtin School of Medical Research, Australian National University, Canberra.
Easteal
S
S
Board
P G
PG
Summers
K M
KM
Bhatia
K K
KK
Kirk
R L
RL
D000483:Alleles; D001208:Asia; D004247:DNA / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D010139:Pacific Islands; D010802:Phylogeny; D012150:Polymorphism, Restriction Fragment Length; D012709:Serum Albumin / Q000235:genetics*; D014809:Vitamin D-Binding Protein / Q000235:genetics*
D012709:Serum Albumin; D014809:Vitamin D-Binding Protein; D004247:DNA