Isolation and characterization of two antimicrobial agents from mace (Myristica fragrans).
The two antimicrobial resorcinols malabaricone B [1] and malabaricone C [2] were isolated from mace, the dried seed covers of Myristica fragrans. Both compounds exhibited strong antifungal and antibacterial activities. Structure modifications by methylation or reduction resulted in diminished activity.
Orabi
K Y
KY
Department of Pharmacognosy and Medicinal, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mossa
J S
JS
el-Feraly
F S
FS
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D012118:Resorcinols; C071788:malabaricone B; C071787:malabaricone C