title: A centromere map of the X chromosome from trisomies of maternal origin.
abstract: A centromere map is derived from XXX and XXY trisomies of maternal origin. Preliminary data suggest reduced recombination in the tetrads giving rise to mei I nondisjunction, but an excess of recombination in the pericentric region. As in Drosophila, multichiasmate tetrads may be more at risk of nondisjunction than nullochiasmate tetrads.
authors.affiliation: CRC Research Group in Genetic Epidemiology, Department of Community Medicine, Southhampton General Hospital, UK.
authors.forename: N E
authors.initials: NE
authors.lastname: Morton
authors.forename: B J
authors.initials: BJ
authors.lastname: Keats
authors.forename: P A
authors.initials: PA
authors.lastname: Jacobs
authors.forename: T
authors.initials: T
authors.lastname: Hassold
authors.forename: D
authors.initials: D
authors.lastname: Pettay
authors.forename: J
authors.initials: J
authors.lastname: Harvey
authors.forename: V
authors.initials: V
authors.lastname: Andrews
mesh_terms: D000818:Animals; D002503:Centromere; D002875:Chromosomes; D003434:Crossing Over, Genetic; D004331:Drosophila melanogaster; D005260:Female; D006801:Humans; D009035:Mothers; D012150:Polymorphism, Restriction Fragment Length; D014314:Trisomy; D014960:X Chromosome