[3 cases of postpartum acquired factor VIII inhibitor].
Three cases of postpartum acquired factor VIII inhibitors were seen in our hospital between 1981 and 1989. The clinical picture, which was mild in one patient and severe in two, began several months after delivery (four to nine). After treatment with methylprednisolone, good clinical response was obtained in the three cases. However, normal values of factor VIII:C were obtained more easily with the higher doses of steroids. A new pregnancy and delivery in one of our patients did not induce the reappearance of the inhibitor after several years of follow-up.
Majado
M J
MJ
Servicio de Hematología, Hospital Virgen de la Arrixaca, Murcia.
Tamayo
M
M
Funes
C
C
Sánchez Peñas
A
A
González García
C
C
Sánchez Blanco
J J
JJ
D000328:Adult; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000209:etiology*; D005169:Factor VIII / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006406:Hematoma / Q000209:etiology* / Q000276:immunology; D006801:Humans; D015994:Incidence; D008775:Methylprednisolone / Q000627:therapeutic use; D011247:Pregnancy; D011644:Puerperal Disorders / Q000276:immunology*; D013924:Thrombophlebitis / Q000209:etiology* / Q000276:immunology
D005169:Factor VIII; D008775:Methylprednisolone
Tres casos de inhibidor del factor VIII adquirido postparto.