title: Ceftazidime vs. tobramycin for serious infections in urological patients.
abstract: A prospective, randomized study was undertaken to compare the efficacy and safety of tobramycin and ceftazidime in the treatment of serious infections in 77 urological patients. Of the 39 tobramycin-treated and 38 ceftazidime-treated patients, 74% and 82%, respectively, were cured clinically. Microbiological cure rates were 72% and 79%, respectively. Three patients treated with tobramycin and two treated with ceftazidime developed a significant superinfection. Both drugs were tolerated well. Because of potential ototoxicity and nephrotoxicity the use of aminoglycosides is less advantageous than ceftazidime for seriously infected urological patients.
authors.affiliation: Urological Unit, Oulu University Central Hospital, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Tammela
authors.forename: M
authors.initials: M
authors.lastname: Kontturi
authors.forename: R
authors.initials: R
authors.lastname: Usenius
authors.forename: S
authors.initials: S
authors.lastname: Uusi-Penttilä
authors.forename: J
authors.initials: J
authors.lastname: Viitanen
authors.forename: K
authors.initials: K
authors.lastname: Jauhiainen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002442:Ceftazidime / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology; D014031:Tobramycin / Q000009:adverse effects / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D014570:Urologic Diseases / Q000601:surgery*
chemical_list: D002442:Ceftazidime; D014031:Tobramycin