Substituent effects on the binding constants of arsenical-dithiol adducts.
Proton nuclear magnetic resonance spectroscopy (1H NMR) was used to determine the relative binding constants for several arsenical-dithiol adducts. The compounds investigated were 2,3-dimercaptopropanol (British anti-lewisite; BAL), 1,2-ethane dithiol (ET), and 1,2-propane dithiol (PDT). It was found that PDT has a significantly higher affinity than ET or BAL for phenyldichloroarsine (PDA) in methanol.
Dill
K
K
Department of Chemistry, Clemson University, SC 29634-1905.
Huang
L H
LH
McGown
E L
EL
Youn
S H
SH
O'Connor
R J
RJ
D001152:Arsenicals / Q000737:chemistry*; D001665:Binding Sites; D004112:Dimercaprol / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008623:Mercaptoethanol / Q000031:analogs & derivatives* / Q000737:chemistry; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D001152:Arsenicals; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; D008623:Mercaptoethanol; C053663:phenyldichloroarsine; C031854:1,2-ethanedithiol; C071142:1,2-dimercaptopropane; D011407:Propane