title: Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure.
abstract: The spontaneously hypertensive rat (SHR) exhibits alterations in the renin-angiotensin-aldosterone system which are similar to those that characterize patients with "nonmodulating" hypertension, a common and highly heritable form of essential hypertension. Accordingly, we determined whether the inheritance of a DNA restriction fragment length polymorphism (RFLP) marking the renin gene of the SHR was associated with greater blood pressure than inheritance of a RFLP marking the renin gene of a normotensive control rat. In an F2 population derived from inbred SHR and inbred normotensive Lewis rats, we found the blood pressure in rats that inherited a single SHR renin allele to be significantly greater than that in rats that inherited only the Lewis renin allele. To the extent that the SHR provides a suitable model of "nonmodulating" hypertension, these findings raise the possibility that a structural alteration in the renin gene, or a closely linked gene, may be a pathogenetic determinant of increased blood pressure in one of the most common forms of essential hypertension in humans.
authors.affiliation: Department of Laboratory Medicine, University of California, San Francisco 94143.
authors.forename: T W
authors.initials: TW
authors.lastname: Kurtz
authors.forename: L
authors.initials: L
authors.lastname: Simonet
authors.forename: P M
authors.initials: PM
authors.lastname: Kabra
authors.forename: S
authors.initials: S
authors.lastname: Wolfe
authors.forename: L
authors.initials: L
authors.lastname: Chan
authors.forename: B L
authors.initials: BL
authors.lastname: Hjelle
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001794:Blood Pressure; D005260:Female; D006973:Hypertension / Q000209:etiology* / Q000235:genetics; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D051381:Rats; D011917:Rats, Inbred Lew; D011918:Rats, Inbred SHR; D012083:Renin / Q000235:genetics*
chemical_list: D012083:Renin