title: Can ibuprofen cause acute renal failure in a normal individual? A case of acute overdose.
abstract: The nonsteroidal antiinflammatory drug (NSAID), ibuprofen, is associated with several renal syndromes, including acute renal failure. NSAID-induced acute renal insufficiency is thought to occur almost exclusively in clinical situations where maintenance of renal blood flow (RBF) is prostaglandin-dependent. However, we present a case of acute renal failure with tubular necrosis occurring as the apparent result of ibuprofen overdose in a patient with no predisposition to NSAID-induced renal failure.
authors.affiliation: Yale-Waterbury Primary Care Residency Program, St. Mary's Hospital, Waterbury, CT.
authors.forename: M A
authors.initials: MA
authors.lastname: Perazella
authors.forename: G K
authors.initials: GK
authors.lastname: Buller
mesh_terms: D062787:Drug Overdose; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000506:poisoning*; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced* / Q000652:urine; D008875:Middle Aged; D014556:Urine / Q000166:cytology
chemical_list: D007052:Ibuprofen