Hemodilution and rehydration in acute ischemic stroke. A preliminary report on the Amsterdam Stroke Study.
The Amsterdam Stroke Study was a prospective, single-center, randomized clinical trial, investigating the effect of normovolemic hemodilution and rehydration with albumin 20% and crystalloids. All patients (n = 300) received general intensive care treatment and monitoring with a pulmonary artery catheter. The therapy was individually "customized" and guided on the pulmonary capillary wedge pressure of 12 +/- 3 mm Hg and for the hemodilution group on a hematocrit of 0.32 +/- 0.02 l/l. The significant differences in the subgroups emphasize the importance of a differentiation between a viscosity effect and an effect in hemodilution therapy, sometimes intensifying, sometimes counteracting each other.
Goslinga
H
H
Department of Rheology, St Lucas Hospital, Amsterdam, The Netherlands.
Heuvelmans
J H
JH
Schmid-Schönbein
H
H
D000418:Albumins / Q000008:administration & dosage; D001809:Blood Viscosity / Q000187:drug effects* / Q000502:physiology; D001810:Blood Volume / Q000187:drug effects / Q000502:physiology; D002545:Brain Ischemia / Q000097:blood / Q000401:mortality / Q000628:therapy*; D002544:Cerebral Infarction / Q000097:blood / Q000401:mortality / Q000628:therapy*; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D005500:Follow-Up Studies; D006400:Hematocrit; D006438:Hemodilution / Q000379:methods*; D006452:Hemoglobinometry; D006801:Humans; D008297:Male; D009426:Netherlands; D011446:Prospective Studies; D012307:Risk Factors; D015996:Survival Rate
D000418:Albumins