[FG syndrome in 2 half brothers].
We report on two half-brothers with the FG syndrome which is an X-linked recessive multiple congenital anomalies/mental retardation (MCA/MR) syndrome. Both patients show postnatal short stature and an altogether characteristic face consisting of droopy appearance, macrocephaly, frontal upsweep, hypertelorism, full lower lip, retrognathia, and dysmorphic ears. Moreover, since early infancy both have a tendency towards constipation, their muscle tone is low and psychomotor development is moderately retarded. Minor expression of this syndrome in the patients' mother and her two mentally retarded brothers give additional support to the X-linked nature of the condition. On the basis of the pertinent literature, a concise description of this MCA/MR syndrome with variable expression is given. Diagnostic evaluation of dysmorphic male patients with psychomotor retardation should always consider the FG syndrome which has been known since 1974 but still is inadequately recognised in the German literature.
Wieg
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Altonaer Kinderkrankenhaus, Hamburg.
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D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008297:Male; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014960:X Chromosome
FG-Syndrom bei zwei Halbbrüdern.