title: Evidence for long-term reduction of noradrenaline release after kindling in the rat hippocampus.
abstract: The in vivo microdialysis technique was used to monitor steady-state noradrenaline release in the rat hippocampus after hippocampal kindling. At 8 weeks after the last seizure, the noradrenaline release was reduced by 62% in the stimulated hippocampus in kindled animals as compared to non-kindled rats. The reduction was not due to the repeated handling of the animals as assessed in a separate experiment. The results suggest a decrease of inhibitory noradrenergic influence at the primary kindling site, which could play a role in kindling epileptogenesis.
authors.affiliation: Department of Medical Cell Research, University of Lund, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Bengzon
authors.forename: P
authors.initials: P
authors.lastname: Kalén
authors.forename: O
authors.initials: O
authors.lastname: Lindvall
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D003956:Dialysis; D006234:Handling, Psychological; D006624:Hippocampus / Q000378:metabolism* / Q000502:physiology; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D009638:Norepinephrine