[Therapeutic effect of amorolfine on experimental dermatophytosis].
Therapeutic effects of cream and solution of amorolfine (MT-861), a new morpholine antifungal agent, were investigated using 1% cream and solution of bifonazole (BFZ) as the reference drug in Trichophyton mentagrophytes-infected guinea pig to evaluate the usefulness of MT-861. The results obtained are summarized as follows. 1. Once-a-day topical applications of 0.125, 0.5, and 1% MT-861 cream preparations starting day-5 postinfection were therapeutically effective. The effectiveness increased with increasing concentrations of active preparations, reaching nearly the maximum level at 0.5%. The treatment with 0.5% or 1% MT-861 cream preparation produced significantly greater improvement of clinical symptoms and culture results than did the treatment with the 1% BFZ cream preparation. 2. Treatment of 7 days or longer with 0.5 or 1% cream of MT-861 was required to produce therapeutic effect. Close relationships were observed between chitin contents of skin lesions and the presence of the pathogen in the lesions after 1, 2 and 3 weeks of treatment. 3. When MT-861 solutions were applied once daily for 2 weeks, the effectiveness increased as drug concentrations increased similarly to the cream treatment. A significant difference was observed (P less than 0.05 approximately 0.001) in degrees of lesions and culture results between the treatment with MT-861 and with BFZ control solutions. Thus, excellent therapeutic effectiveness in the Trichophyton infection model of guinea pigs was obtained by treatment with both the cream and the solution of MT-861. Once a day dosage of 0.5% drug concentration produced adequate effectiveness. A high clinical usefulness is expected in the treatment of fungal infections of the skin using MT-861.
Uchida
K
K
Teikyo University Research Center for Medical Mycology.
Matsuzaka
A
A
Yamaguchi
H
H
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000188:drug therapy*; D005260:Female; D006168:Guinea Pigs; D007093:Imidazoles / Q000494:pharmacology; D009025:Morpholines / Q000494:pharmacology / Q000627:therapeutic use*; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D007093:Imidazoles; D009025:Morpholines; C038974:amorolfine; C036596:bifonazole