title: New antitumor promoters: (-)-epigallocatechin gallate and sarcophytols A and B.
abstract: EGCG, the main constituent of green tea, and sarcophytols A and B, isolated from a soft coral, inhibited tumor promotion by teleocidin in a two-stage carcinogenesis experiment on mouse skin. EGCG and sarcophytols showed inhibition of tumor development by chemical carcinogenesis. A possibility of developing these compounds as cancer chemopreventives for human beings is discussed.
authors.affiliation: Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Fujiki
authors.forename: M
authors.initials: M
authors.lastname: Suganuma
authors.forename: H
authors.initials: H
authors.lastname: Suguri
authors.forename: K
authors.initials: K
authors.lastname: Takagi
authors.forename: S
authors.initials: S
authors.lastname: Yoshizawa
authors.forename: A
authors.initials: A
authors.lastname: Ootsuyama
authors.forename: H
authors.initials: H
authors.lastname: Tanooka
authors.forename: T
authors.initials: T
authors.lastname: Okuda
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Sugimura
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives*; D003063:Cnidaria / Q000032:analysis; D003043:Cocarcinogenesis; D004224:Diterpenes / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000627:therapeutic use*; D008235:Lyngbya Toxins / Q000633:toxicity; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control*; D051379:Mice; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013662:Tea / Q000032:analysis*
chemical_list: D004224:Diterpenes; D005419:Flavonoids; D008235:Lyngbya Toxins; D013662:Tea; C058761:sarcophytol A; C022176:teleocidins; D015127:9,10-Dimethyl-1,2-benzanthracene; C058762:sarcophytol B; D002392:Catechin; C057580:gallocatechol