[Anti-lipidperoxidation and cerebral protective effects of clausenamide].
Clausenamide is a compound isolated from Clausena lansium (lour) with the structure similar to piracetam. Pharmacological experiments showed that clausenamide po 100-200 mg/kg prolonged both the duration of gasping after decapitation and the survival time after sc NaNO2 225 mg/kg, clausenamide at the concentration of 10(-5) mol/L inhibited the contraction of basilar artery caused by 5-HT, PGF2 alpha and arachidonic acid, indicating that clausenamide is a cerebral protective agent. In addition, multiple doses clausenamide were shown to inhibit the liver lipid peroxidation caused by 50% alcohol and increase the GSH-peroxidase activity significantly in rat liver and brain cytosol.
Liu
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Y
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Shi
C Z
CZ
Zhang
J T
JT
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D002534:Hypoxia, Brain / Q000517:prevention & control; D007769:Lactams / Q000494:pharmacology*; D017705:Lignans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects*; D014665:Vasodilator Agents
D007769:Lactams; D017705:Lignans; D014665:Vasodilator Agents; C053048:clausenamide; D008315:Malondialdehyde; D005979:Glutathione Peroxidase