Guanylate cyclase in human platelets with different aggregability.
The activity of human platelet guanylate cyclase, and the activation of the enzyme by sodium nitroprusside were decreased in platelets with increased aggregability; these platelets were obtained from diabetes mellitus patients. Anomalies in guanylate cyclase activity and ADP-induced aggregation were more pronounced in platelets from subjects with type II than those with type I diabetes.
Chirkov YuYu
Institute of Biological and Medical Chemistry, USSR Academy of Medical Sciences, Moscow.
Tyshchuk
I A
IA
Severina
I S
IS
D000244:Adenosine Diphosphate; D001792:Blood Platelets / Q000201:enzymology*; D003920:Diabetes Mellitus / Q000097:blood / Q000201:enzymology; D005260:Female; D006162:Guanylate Cyclase / Q000097:blood*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation
D000244:Adenosine Diphosphate; D006162:Guanylate Cyclase