No involvement of alpha 2-adrenoceptors in the regulation of basal prolactin secretion in healthy men.
The role of alpha 2-adrenoceptors in the regulation of basal prolactin secretion was investigated in healthy male volunteers. Two independent, placebo-controlled, double-blind experiments were performed. In the first experiment, 50 micrograms dexmedetomidine (MPV-1440), a selective alpha 2-adrenoceptor agonist, and saline placebo were infused (IV) in five subjects. In the second experiment, 100 mg atipamezole (MPV-1248), a selective alpha 2-adrenoceptor antagonist, and saline placebo were infused in six volunteers. The concentrations of prolactin in plasma were not affected by the drugs. These results suggest that alpha 2-adrenoceptors do not a play significant role in the control of basal prolactin secretion in healthy men.
Karhuvaara
S
S
Department of Pharmacology, University of Turku, Finland.
Kallio
A
A
Koulu
M
M
Scheinin
H
H
Scheinin
M
M
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000328:Adult; D000704:Analysis of Variance; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D020926:Medetomidine; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000502:physiology; D012016:Reference Values
D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; D011942:Receptors, Adrenergic, alpha; C050701:atipamezole; D011388:Prolactin; D020926:Medetomidine