Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans.
Four mutant genes (unc-17, unc-18, unc-41 and unc-13) have been identified that result in abnormal accumulation of acetylcholine (ACh). We have now identified 3 more such genes (unc-63, unc-11 and unc-64). In addition to the abnormal accumulation of ACh, mutants in these 7 genes possess common phenotypes in locomotion, resistance to inhibitors of acetylcholinesterase (AChE) and in post-embryonic development. These results suggest that the 7 genes are involved in some related functions.
Hosono
R
R
Department of Biochemistry, School of Medicine, Kanazawa University, Japan.
Kamiya
Y
Y
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002107:Caenorhabditis / Q000235:genetics*; D005838:Genotype; D009154:Mutation; D010641:Phenotype; D014236:Trichlorfon / Q000494:pharmacology
D014236:Trichlorfon; D000109:Acetylcholine