Anti-imipramine antibodies recognize endogenous serotonin uptake and imipramine binding inhibitors.
Calf brain and human platelet extracts purified by Bio-Gel P2 column chromatography contained substances that inhibited serotonin uptake and 3H-imipramine binding. Some of these endogenous substances were also recognized by rabbit antibodies produced against imipramine. The data suggest the possible existence of endogenous serotonin uptake modulators, which may possess a partial molecular structure similar to that identified by the antibodies.
Tang
S W
SW
Long Beach Veterans Affairs Medical Center, CA 90822.
Cheung
S
S
Strijewski
A
A
Chudzik
J
J
Helmeste
D
D
D000818:Animals; D000906:Antibodies; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D002417:Cattle; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D007099:Imipramine / Q000276:immunology* / Q000493:pharmacokinetics; D011869:Radioligand Assay; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000097:blood*; D012702:Serotonin Antagonists
D000906:Antibodies; D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C027775:imipramine receptor; D012701:Serotonin; D007099:Imipramine