title: Plasma and cerebrospinal fluid concentration of temazepam following oral drug administration.
abstract: Thirteen male patients were administered 20 mg of temazepam orally 1 to 2 h prior to undergoing spinal anaesthesia for a urological procedure. Samples of blood and CSF were drawn just before insertion of the spinal and the concentration of drug estimated in these two media. The results obtained indicated that a highly significant correlation existed between the unbound concentration of temazepam in plasma and the concentration of drug present in CSF. Temazepam appeared to be an effective light pre-medicant in all of the subjects studied.
authors.affiliation: Department of Chemical Pathology, Adelaide Children's Hospital, South Australia.
authors.forename: N R
authors.initials: NR
authors.lastname: Badcock
authors.forename: G A
authors.initials: GA
authors.lastname: Osborne
authors.forename: T L
authors.initials: TL
authors.lastname: Nyman
authors.forename: L N
authors.initials: LN
authors.lastname: Sansom
authors.forename: W J
authors.initials: WJ
authors.lastname: Russell
authors.forename: D B
authors.initials: DB
authors.lastname: Frewin
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics*; D001798:Blood Proteins / Q000378:metabolism; D002849:Chromatography, Gas; D003956:Dialysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D013693:Temazepam / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*
chemical_list: D014151:Anti-Anxiety Agents; D001798:Blood Proteins; D013693:Temazepam