[Use of preventive intra-operative antibiotic administration in appendectomy. A pharmacokinetic study].
Studies on Cefazedone-kinetics in serum and subcutaneous fat tissue showed an early and lasting tissue concentration high above minimal inhibitation concentrations so that intraoperative single-shot administration of antibiotics are proven to be effective. Due to these pharmacokinetic patterns the results of an earlier prospective trial is confirmed that single-shot antibiotics during surgery are useful to reduce postoperative wound sepsis rate after appendectomy.
Adamek
L
L
Chirurgische Klinik, Evangelischen Krankenhauses Mülheim a.d. Ruhr.
Mayer
F
F
Wolf
R
R
Raguse
T
T
D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001062:Appendectomy; D001064:Appendicitis / Q000097:blood* / Q000601:surgery*; D001412:Bacillus subtilis / Q000187:drug effects; D002437:Cefazolin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008795:Metronidazole / Q000008:administration & dosage / Q000493:pharmacokinetics; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011292:Premedication; D013530:Surgical Wound Infection / Q000097:blood* / Q000517:prevention & control*
D000892:Anti-Infective Agents, Urinary; D008795:Metronidazole; C021341:cefazedone; D002437:Cefazolin
Nutzen der intraoperativen Antibiotikaprophylaxe bei Appendektomie. Eine pharmakokinetische Studie.