title: ACTH and steroids in Kugelberg-Welander disease.
abstract: Two brothers with the chronic proximal form of spinal muscular atrophy (Kugelberg-Welander syndrome) were administered with ACTH and prednisone and a repeated remarkable and prompt improvement of the symptoms of this disease could be registered. Since similar experiences has recently been reported by other authors in hereditary sensory and motor neuropathy, a hypothesis is put forward of the possible participation of autoimmune mechanisms in the pathogenesis of some forms of hereditary so-called degenerative diseases of the peripheral motor neuron.
authors.affiliation: Clinic of Neurology, University Hospital, Olomouc.
authors.forename: K
authors.initials: K
authors.lastname: Urbánek
authors.forename: J
authors.initials: J
authors.lastname: Chudácková
authors.forename: J
authors.initials: J
authors.lastname: Velísková
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D009134:Muscular Atrophy, Spinal / Q000188:drug therapy* / Q000235:genetics; D011241:Prednisone / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000324:Adrenocorticotropic Hormone; D011241:Prednisone