[The influence of the synthetic antioxidant fenozan-K on the effects of pentobarbital during dissociative learning].
Dependence was studied of pentobarbital effects at dissociated learning in rats of KM line after intraperitoneal injection of antioxidant phenozan-K. It was shown that preliminary (before 1.5 hour) injection of 40 mg/kg of phenozan-K to animals changed the composition (index of oxidation S) of cells lipids of rats brain membranes and simultaneously increased the sensitivity to pentobarbital. Injection of half a dose of pentobarbital, which caused dissociated state, against the background of antioxidant action had the same effect as the full dose (15 mg/kg).
Arkhipov
V I
VI
Arkhipova
G V
GV
Fedotova
I B
IB
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004213:Dissociative Disorders / Q000139:chemically induced* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D010424:Pentobarbital / Q000494:pharmacology*; D010666:Phenylpropionates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000975:Antioxidants; D008563:Membrane Lipids; D010666:Phenylpropionates; D010424:Pentobarbital; C047854:fenozan
Vliianie sinteticheskogo antioksidanta fenozana-K na éffekty pentobarbitala pri dissotsiirovannom obuchenii.