[Calcium binding capacity of erythrocyte membrane in human hypertension and spontaneous hypertensive rats].
Several abnormalities of calcium transport have been reported in human essential hypertension (EHT) and spontaneous hypertensive rat (SHR). 45Ca binding capacity to erythrocyte membrane was measured in this study by filtration technique in the presence of 80 nmol/L Ca concentration. Results showed: (1) It was much lower in EHT (33 cases) than normal control (19 men) group, being 0.22 +/- 0.13 versus 0.35 +/- 0.18 nmol Ca2+/mg membrane protein (P less than 0.01), and correlated positively with blood pressure levels. (2) The average Ca binding capacity in young offsprings (15 adolescents) with both parents hypertensive was lower, but statistically not significant. (3) The average Ca binding capacity was also lower in SHR (9 rats) than control WKY (10 rats) group, being 0.83 +/- 0.27 versus 0.98 +/- 0.24 nmol Ca2+/mg membrane protein, yet statistically not significant. Therefore a decrement of membrane binding capacity might be related to the occurrence and maintenance of hypertension.
Zhao
G
G
Shanghai Institute of Hypertension, Shanghai Second Medical University.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001665:Binding Sites; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008875:Middle Aged; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D015220:Calcium Channels; D008565:Membrane Proteins; D002118:Calcium