Chronic rejection of rat aortic allograft. II. Administration of cyclosporin induces accelerated allograft arteriosclerosis.
Rat aortic allografts immunosuppressed with cyclosporin--but not with azathioprine or steroids--develop an early inflammatory lesion in the subendothelial space. This "endothelialitis" is followed by an influx of proliferating smooth muscle cells into the intima, resulting in intimal thickening and accelerated arteriosclerosis. Administration of azathioprine and steroids largely ameliorates the development of the accelerated lesion. Similar endothelialitis and accelerated arteriosclerosis have been observed previously in the autopsy material of cardiac transplant recipients. Our results confirm the suggestion that the development of accelerated allograft arteriosclerosis is most likely linked to cyclosporin administration.
Mennander
A
A
Fourth Department of Surgery, University of Helsinki, Finland.
Tiisala
S
S
Paavonen
T
T
Halttunen
J
J
Häyry
P
P
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000473:pathology / Q000637:transplantation*; D001161:Arteriosclerosis / Q000139:chemically induced* / Q000473:pathology; D001379:Azathioprine / Q000627:therapeutic use; D016572:Cyclosporine / Q000633:toxicity*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D007124:Immunoenzyme Techniques; D007165:Immunosuppression Therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D051381:Rats; D013997:Time Factors; D014184:Transplantation, Homologous
D016572:Cyclosporine; D001379:Azathioprine; D008775:Methylprednisolone