Further observations on the prevention of experimental proliferative vitreo-retinopathy by 5-fluorouracil.
The rate of retinal detachment in fellow control eyes of rabbits following fibroblast administration is progressively lower with increased dose of 5-Fluorouracil in the test eyes. Thus, it seems mandatory to choose control eyes in other animals rather than the fellow eyes of the treated ones. Retinal detachment appeared in the second week or earlier after intravitreal fibroblast administration. However, in eyes treated intravitreally with 5-Fluorouracil, retinal detachment or pucker appeared later, even in the second month suggesting routine follow-up of at least 2 months in future studies.
Ophir
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Department of Ophthalmology, Hadassah University Hospital, Ein Karem, Jerusalem, Israel.
D000818:Animals; D004195:Disease Models, Animal; D005128:Eye Diseases / Q000517:prevention & control; D005347:Fibroblasts / Q000473:pathology; D005472:Fluorouracil / Q000627:therapeutic use*; D005500:Follow-Up Studies; D011817:Rabbits; D012163:Retinal Detachment / Q000209:etiology; D012164:Retinal Diseases / Q000517:prevention & control*; D014822:Vitreous Body / Q000187:drug effects
D005472:Fluorouracil