[Effect of endotoxin on aggregation and release of human platelet in vitro].
The effect of endotoxin on human platelet was studied in vitro. E Coli O55B5 endotoxin inhibited spontaneous platelet aggregation but had no effect on platelet aggregation by epinephrine and the release of contents from dense granule, alpha-granule of platelet. The endotoxin also elevated cAMP and increased the activity of calmodulin in platelet, which might account for the effect of the endotoxin on platelet. In addition, a reduced concentration of 5-HT in the supernate of endotoxin group was also observed.
He
K
K
Daping Hospital, Third Military Medical College, Chongqing.
Liou
H Q
HQ
D001792:Blood Platelets / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D002147:Calmodulin; D004731:Endotoxins; D010975:Platelet Aggregation Inhibitors; D000242:Cyclic AMP