title: An experimental model for the surgical correction of tracheomalacia.
abstract: Tracheomalacia may result from large intrathoracic goiters. Due to the chronic compression, particularly within the confines of the thoracic inlet, the tracheal wall weakens, with disintegration of some of the cartilaginous rings. Tracheomalacia can cause acute airway distress, particularly during the post-operative period, and may occasionally result in death. The other major cause of tracheomalacia is related to either prolonged endotracheal intubation or over-inflation of the tracheostomy cuff. While various techniques such as internal stenting, external support devices, tracheostomy, and tracheal resection have been used based on individual circumstances, no one method appears to be perfect. To further study this difficult problem, an experimental model of tracheomalacia was created in eight dogs. Six to seven rings of the tracheal cartilages were dissected submucosally. More than half of the circumference of the tracheal rings was resected. The tracheal walls were reconstructed with polytetrafluoroethylene (PTFE) grafts. The grafts strengthened the tracheal wall without causing luminal constriction. Tracheostomy was not performed on any of the dogs. All dogs tolerated the procedure well and were extubated at the conclusion of the experiment. The dogs were followed for 4 to 6 months and then sacrificed so that the tracheal wall could be examined histologically. There was considerable fibrosis leading to stiff neotrachea. The results of this experimental technique for prosthetic reconstruction to counteract problems simulating tracheomalacia are very encouraging.
authors.affiliation: Department of Surgery, SUNY-Health Science Center, Brooklyn 11203.
authors.forename: A R
authors.initials: AR
authors.lastname: Shaha
authors.forename: C
authors.initials: C
authors.lastname: Burnett
authors.forename: T
authors.initials: T
authors.lastname: DiMaio
authors.forename: B M
authors.initials: BM
authors.lastname: Jaffe
mesh_terms: D000818:Animals; D004285:Dogs; D011138:Polytetrafluoroethylene; D015607:Stents; D014132:Trachea / Q000601:surgery*; D014133:Tracheal Diseases / Q000209:etiology / Q000601:surgery*
chemical_list: D011138:Polytetrafluoroethylene