title: Brachytherapy: a viable alternative in the management of basal meningiomas.
abstract: Thirteen patients with intracranial meningiomas of the skull base were treated with one or more high-activity iodine-125 seeds. In 11 patients, the seeds were implanted stereotactically under local anesthesia. A minimum dose of 100 to 500 Gy was delivered to the tumor at a dose rate of 5 to 25 cGy/h. Indications for this procedure included recurrence after initial surgery or as the primary modality of treatment in patients who were not candidates for surgery. All 13 patients are alive at a median follow-up of 15 months. Nine of 11 patients (82%) without calcification in their meningiomas achieved complete response. The remaining 4 patients-2 with calcification and 2 without--achieved partial response. No early or late complications were observed. We conclude from our experience that both recurrent and primary meningiomas of the skull base can be treated effectively with permanent iodine-125 brachytherapy.
authors.affiliation: Division of Radiation Oncology, University of Nebraska Medical Center, Omaha.
authors.forename: P P
authors.initials: PP
authors.lastname: Kumar
authors.forename: A A
authors.initials: AA
authors.lastname: Patil
authors.forename: L G
authors.initials: LG
authors.lastname: Leibrock
authors.forename: W K
authors.initials: WK
authors.lastname: Chu
authors.forename: J
authors.initials: J
authors.lastname: Syh
authors.forename: G F
authors.initials: GF
authors.lastname: McCaul
authors.forename: M A
authors.initials: MA
authors.lastname: Reeves
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D008579:Meningioma / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011859:Radiography; D013238:Stereotaxic Techniques
chemical_list: D007457:Iodine Radioisotopes