[The participation of the GABA-A and GABA-B receptors in the mechanism of the inhibition of the contractile activity in the rabbit myometrium under the influence of GABA, AOAA and fenibut].
Experiments on isolated strips of the rabbit uterus showed the stimulating effects of small doses of GABA, AOAA and phenibut on uterine contractility, while large doses exerted the reverse (suppressing) effects. Administration of bicuculline and picrotoxin before or after the above-mentioned drugs reduced their suppressing effects on uterine muscle contractility. The data postulate the involvement of GABAA and GABAB receptors in the drugs action on the rabbit uterus.
Sizov
P I
PI
Iasnetsov
V S
VS
D000625:Aminooxyacetic Acid / Q000494:pharmacology*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D066298:In Vitro Techniques; D010852:Picrotoxin / Q000494:pharmacology; D011817:Rabbits; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D014590:Uterine Contraction / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000625:Aminooxyacetic Acid; D001640:Bicuculline; D010852:Picrotoxin; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid
Uchastie GAMK-A- i GAMK-B-retseptorov v mekhanizme tormozheniia sokratitel'noĭ aktivnosti miometriia krolikov pod vliianiem GAMK, AOUK i fenibuta.