Fenfluramine augmentation of clomipramine treatment of obsessive compulsive disorder.
Recently, much research interest has been directed to demonstrating a possible biological basis to obsessive compulsive disorder. In particular, dysregulation in brain serotonin is suggested to be important. Two cases are described in which fenfluramine, a presynaptic 5 HT-releasing agent and 5HT-reuptake inhibitor was used to augment clomipramine treatment for OCD.
Judd
F K
FK
University of Melbourne, Department of Psychiatry, Austin Hospital, Heidelberg, Vic.
Chua
P
P
Lynch
C
C
Norman
T
T
D000328:Adult; D002997:Clomipramine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005277:Fenfluramine / Q000008:administration & dosage*; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000523:psychology* / Q000628:therapy*
D005277:Fenfluramine; D002997:Clomipramine