Multinuclear forms in a dyskinetoplastic strain of Trypanosoma evansi in mice.
The production of short stumpy and multinuclear trypanosomes in a Chinese strain of dyskinetoplastic Trypanosoma evansi maintained in rabbits and mice is described. Production of multinuclear trypanosomes was increased following passage through a reptile (gecko), in which the trypanosomes did not multiply, and transfer back to mice. The multinuclear trypanosomes showed more nuclei than flagella indicating that disruption of the normal cell cycle had taken place and not simply inhibition of cleavage. A Chinese kinetoplastic T. evansi treated similarly rarely produced stumpy or multinuclear forms.
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D000818:Animals; D002453:Cell Cycle; D002467:Cell Nucleus; D008116:Lizards; D051379:Mice; D014345:Trypanosoma / Q000648:ultrastructure*