17-Hydroxyprogesterone level as a marker for corpus luteum function in aborters versus nonaborters.
Weekly serum levels of 17-hydroxyprogesterone (17-OHP) levels and serum progesterone (P) levels were measured in 378 pregnant women. Normal levels of 17-OHP were established in women taking ovulation-inducing drugs (OVID) versus those conceiving on normal cycles. Weekly levels of 17-OHP were measured in women who aborted and were compared with the established norms. The levels of 17-OHP in aborters were lower than in normals for their specific category established in nonaborters. These results suggest that a failing corpus luteum may contribute to some abortions. Careful attention to 17-OHP levels dropping below normal during the first trimester may alert the clinician to the need to increase progesterone exogenously and possibly prevent an abortion.
Check
J H
JH
Department of Obstetrics and Gynecology, UMDNJ, Robert Wood Johnson Medical School, Camden.
Vaze
M M
MM
Epstein
R
R
Wu
C H
CH
Quattrocchi
J
J
Vetter
B
B
D019326:17-alpha-Hydroxyprogesterone; D000022:Abortion, Spontaneous / Q000097:blood* / Q000503:physiopathology; D006063:Chorionic Gonadotropin / Q000097:blood; D003338:Corpus Luteum / Q000378:metabolism*; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood*; D010062:Ovulation Induction; D011247:Pregnancy; D011374:Progesterone / Q000097:blood
D006063:Chorionic Gonadotropin; D006908:Hydroxyprogesterones; D011374:Progesterone; D019326:17-alpha-Hydroxyprogesterone