[Genetic predisposition to hypercholesterolemia and coronary heart disease. DNA polymorphism in the apolipoprotein B gene as a possible cause].
It has been demonstrated in numerous studies that hypercholesterolemia is an important independent risk factor for the development of coronary heart disease. Besides exogenous factors like diet and physical exercise genetic predisposition is a major determinant of serum cholesterol levels. Apolipoprotein B-100 (apo B-100) is the protein constituent of LDL which serves as ligand to the LDL-receptor. A hypervariable region containing repetitive elements adjacent to the apo B gene was used as marker to study the role of genetic variation in this gene in the development of elevated serum lipid levels and premature coronary heart disease. A group unrelated patients with severe coronary heart disease and normal controls were studied. Using a high resolution method we could identify 14 different alleles. Alleles with a large number of repetitive elements were associated with coronary heart disease. The same alleles were weakly associated with elevated levels of serum levels of cholesterol, triglycerides and apolipoprotein B.
Friedl
W
W
I. Medizinischen Abteilung, Landeskrankenanstalten Salzburg.
D000483:Alleles; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000235:genetics*; D003327:Coronary Disease / Q000097:blood / Q000235:genetics* / Q000534:rehabilitation; D004247:DNA / Q000235:genetics*; D004562:Electrocardiography; D005080:Exercise Test; D005784:Gene Amplification / Q000235:genetics; D005787:Gene Frequency; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000235:genetics* / Q000534:rehabilitation; D008055:Lipids / Q000097:blood; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics / Q000534:rehabilitation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011973:Receptors, LDL / Q000235:genetics; D012307:Risk Factors
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D008055:Lipids; D011973:Receptors, LDL; D004247:DNA
Genetische Prädisposition zu Hypercholesterolämie und koronare Herzkrankheit. DNS-Polymorphismus im Apolipoprotein-B-Gen als mögliche Ursache.