[Mechanism of the development of drug resistance in protracted depressive conditions (morphometric study of the hypothalamus)].
A polynomial approximation of the relationship between the age and the nucleus volume of the hypothalamic neurosecretory cells was made. This parameter increased approximately 150 times from the neonatal period to 4 years of age and subsequently it remained practically unchanged. In manic-depressive psychosis (depressive phase), it was 1.4 times and in involutional depression 2 times lower than in healthy adults. This fact indicates the secretion lowering which supports desynchronism. A conclusion is drawn that the low efficiency of the therapy of lingering depressions could be accounted for by the insufficiently intense and oriented influence on their pathogenetic substrate--the neurosecretory cells of the supraoptic and paraventricular nuclei of the hypothalamus.
Sonnik
G T
GT
Shul'ga
A I
AI
Ivanishchenko
G E
GE
Kovachev
V I
VI
D000328:Adult; D000367:Age Factors; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000473:pathology*; D002452:Cell Count / Q000187:drug effects; D002648:Child; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000473:pathology*; D004351:Drug Resistance; D006801:Humans; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000473:pathology*; D013495:Supraoptic Nucleus / Q000187:drug effects / Q000473:pathology*
D000928:Antidepressive Agents
Mekhanizm vozniknoveniia terapevticheskoĭ rezistentnosti pri zatiazhnykh depressivnykh sostoianiiakh (morfometricheskoe issledovanie gipotalamusa.