Action of benzene metabolites on murine hematopoietic colony-forming cells in vitro.
Five benzene metabolites--phenol, catechol, hydroquinone, parabenzoquinone, and trans,trans-muconaldehyde--were tested in vitro in murine hematopoietic cell cultures for erythrocytic (BFU-E and CFU-E) and granulocytic (CFU-C) colony growth. The dose range was 4 x 10(-4) to 4 x 10(-8) M. Of these compounds, phenol showed the lowest toxicity. In general, CFU-E cultures were far more sensitive than CFU-C and BFU-E. The results are discussed in relation to the test system used, the in vivo sensitivity of CFU-E, and the lack of knowledge about in vivo concentrations of these compounds.
Seidel
H J
HJ
Institute for Occupational and Social Medicine, University of Ulm, Germany.
Barthel
E
E
Schäfer
F
F
Schad
H
H
Weber
L
L
D000818:Animals; D001554:Benzene / Q000378:metabolism* / Q000494:pharmacology; D015672:Erythroid Precursor Cells / Q000187:drug effects; D005260:Female; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D019800:Phenol; D010636:Phenols / Q000633:toxicity
D010636:Phenols; D019800:Phenol; D001554:Benzene