[Tiopronin, an example of hydrosulphonated derivatives used in the treatment of rheumatoid polyarthritis. Study of immunologic effects].
Fifteen patients with rheumatoid arthritis were treated with tiopronine, and an immunological check-up carried out before the onset and after a two-month treatment. The latex test titres decreased, and there was a significant fall in the levels of IgA-containing circulating immune complexes, in parallel with a depletion of plasma complement breakdown products. Patients displayed a decrease in CD8+T cells and in CD4+Leu 8-T cells and a high proportion of activated T lymphocytes. This returned to normal after treatment. Treatment with TP led also to a reduction of adherence and chemotaxis of polymorphonuclear cells.
Youinou
P
P
Laboratoire d'Immunologie, CHRU, Brest.
Delecoeuillerie
G
G
Fauquert
P
P
Lelong
A
A
Dumay
A
A
Le Goff
P
P
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D012898:Autacoids / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D008625:Tiopronin / Q000494:pharmacology / Q000627:therapeutic use*
D012898:Autacoids; D008625:Tiopronin
La tiopronine, un exemple de dérivés sulfhydrilés utilisé dans le traitement de la polyarthrite rhumatoïde. Etude des effets immunologiques.