Role of guanidine group at the N-terminal proctolin chain in cardioexcitatory effects in insects.
Six proctolin analogues (I-VI) modified in position 1 of the peptide chain by the following amino acids: homo-Arg, Gac, Gav, Gap, Phe (p-guanidino) and Orn, were synthesized by conventional liquid phase method. The myotropic activity of the obtained peptides was investigated in cardioexcitatory test on two insect species, cockroach, Periplaneta americana L., and yellow mealworm, Tenebrio molitor.
Konopińska
D
D
Institute of Chemistry, Wrocław University, Poland.
Rosiński
G
G
Bartosz-Bechowski
H
H
Lesicki
A
A
Sujak
P
P
Sobótka
W
W
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003058:Cockroaches / Q000187:drug effects; D006146:Guanidines / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D007313:Insecta / Q000187:drug effects*; D009479:Neuropeptides; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D010449:Peptide Mapping; D013268:Stimulation, Chemical; D013712:Tenebrio / Q000187:drug effects
D006146:Guanidines; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D009842:Oligopeptides; C011536:proctolin