A locus for X-linked congenital stationary night blindness is located on the proximal portion of the short arm of the X chromosome.
Linkage between X-linked congenital stationary night blindness (CSNB1) and seven markers on the X chromosome was investigated in a large four-generation Albertan kindred. We detected significant linkage between the CSNB1 locus and the locus DXS255 (maximum lod score = 6.73 at a recombination fraction of 6%; confidence interval of 1% to 18%), which anchors the CSNB1 locus to the proximal region near p11.22 on the short arm of the X chromosome.
Bech-Hansen
N T
NT
Alberta Children's Hospital Research Center, Calgary, Canada.
Field
L L
LL
Schramm
A M
AM
Reedyk
M
M
Craig
I W
IW
Fraser
N J
NJ
Pearce
W G
WG
D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009755:Night Blindness / Q000151:congenital / Q000235:genetics*; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D015183:Restriction Mapping; D014960:X Chromosome
D005819:Genetic Markers