title: Role of an indigenous drug geriforte on blood levels of biogenic amines and its significance in the treatment of anxiety neurosis.
abstract: In the recent past, several herbal drugs have proved their efficacy in decreasing anxiety and tension. Until recently, limited scientific study has been done to prove the clinical importance of these herbal drugs. Geriforte is an indigenous compound commonly advocated for arresting the aging process. This remedy has also been found beneficial in reducing anxiety and stress.-34 diagnosed cases of anxiety neurosis and 24 apparently normal individuals were selected for the present study. After 12 weeks of drug therapy a significant reduction in 5-HT levels was observed. Circulating MAO and GABA showed an increasing trend along with decreased glutamic acid levels after treatment, in the neurotic anxiety cases. Psychological complaints considerably decreased after 12 weeks of therapy. Since Geriforte regulates the altered circulating biogenic amines, this remedy can be advocated as an adjunctive therapy in the management of stress disorders.
authors.affiliation: Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
authors.forename: L
authors.initials: L
authors.lastname: Upadhyaya
authors.forename: A K
authors.initials: AK
authors.lastname: Tiwari
authors.forename: A
authors.initials: A
authors.lastname: Agrawal
authors.forename: G P
authors.initials: GP
authors.lastname: Dubey
mesh_terms: D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D019684:Magnoliopsida; D008995:Monoamine Oxidase / Q000097:blood*; D010936:Plant Extracts / Q000494:pharmacology*; D012701:Serotonin / Q000097:blood*; D005680:gamma-Aminobutyric Acid / Q000097:blood
chemical_list: D014151:Anti-Anxiety Agents; D010936:Plant Extracts; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; C047351:geriforte; D008995:Monoamine Oxidase