title: Plasma immunoreactive endothelin-1 concentration in human fetal blood: its relation to asphyxia.
abstract: To elucidate the effects of birth stress on immunoreactive endothelin-1 (irET-1) concentrations in fetal blood, we determined irET-1 levels in cord plasma in different modes of delivery associated with or without complications such as asphyxia. The irET-1 concentrations in both the umbilical artery and vein were significantly higher than those found in maternal venous blood at delivery, although there was no significant difference between preterm and full-term infants. When plasma irET-1 concentrations of healthy infants born by vaginal delivery and by cesarean section without labor were compared, the former had significantly (p less than 0.05) higher levels than the latter (15.4 +/- 4.9 pg/mL versus 11.1 +/- 3.1 pg/mL). Furthermore, umbilical venous plasma obtained from vaginally delivered infants complicated by asphyxia showed significantly (p less than 0.001) higher irET-1 levels (28.2 +/- 9.4 pg/mL) than those of nonasphyxiated infants (14.2 +/- 4.5 pg/m). These data suggest that birth stress, especially asphyxia, may contribute to the increase in fetal circulating irET-1 levels.
authors.affiliation: Department of Pediatrics, Kansai Medical University, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Isozaki-Fukuda
authors.forename: T
authors.initials: T
authors.lastname: Kojima
authors.forename: Y
authors.initials: Y
authors.lastname: Hirata
authors.forename: A
authors.initials: A
authors.lastname: Ono
authors.forename: S
authors.initials: S
authors.lastname: Sawaragi
authors.forename: I
authors.initials: I
authors.lastname: Sawaragi
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D001238:Asphyxia Neonatorum / Q000097:blood*; D016232:Endothelins / Q000097:blood* / Q000276:immunology; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007120:Immunochemistry; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011247:Pregnancy; D013312:Stress, Physiological / Q000097:blood
chemical_list: D016232:Endothelins