Gastric mucosal cytoprotection in the rat by naftidrofuryl oxalate.
Ischaemic gastric mucosal injury was assessed in the rat by measurement of the area of the injury produced after 6 h by reserpine (5 mg kg-1 i.p.) or 5-hydroxytryptamine (5-HT) (50 mg kg-1 i.p.). Pretreatment with naftidrofuryl 1 mL, 1% by gavage significantly (P less than 0.001) protected the rat stomach against the reserpine (24 +/- 2.7 mm2 vs 40 +/- 4.7 mm2, mean +/- s.e.m., n = 10) and 5-HT injury (11.4 +/- 1.7 mm2 vs 27 +/- 4.1 mm2, mean +/- s.e.m., n = 10). Naftidrofuryl 1 mL 2% by gavage was more effective (P less than 0.001) in this respect and mucosal injury only developed in 50% of rats injected with reserpine (9.4 +/- 1.1 mm2) and 30% of those injected with 5-HT (3.2 +/- 0.4 mm2). Administration of naftidrofuryl 1 mL 5% by gavage completely protected the rat against both the reserpine- and 5-HT-induced acute gastric mucosal injury. This protection was not associated with any significant influence on the H+ output.
Salim
A S
AS
University Department of Surgery, Royal Infirmary, Glasgow, UK.
D000818:Animals; D000897:Anti-Ulcer Agents; D005260:Female; D005663:Furans / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009257:Nafronyl / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D005663:Furans; D012701:Serotonin; D009257:Nafronyl; D012110:Reserpine