The effect of the alpha 2-HS-glycoprotein on the mitogen-induced lymphoblastic transformation and IL-2 production.
Authors investigated the in vitro effect of alpha 2-HS-glycoprotein on the lymphoblastic transformation and interleukin-2 production. The observations were made on the peripheral blood lymphocytes of healthy persons, on those of women taking oral contraceptives and on those of patients with systemic lupus erythematosus. The alpha 2-HS-glycoprotein inhibited the mitogen responses both in physiologic and in the halved concentrations. The inhibition of the interleukin-2 production seemed less remarkable.
Jakab
L
L
3rd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
Jakab
L
L
Kalabay
L
L
Pozsonyi
T
T
Cseh
K
K
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000494:pharmacology*; D003277:Contraceptives, Oral, Combined; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D001798:Blood Proteins; D003277:Contraceptives, Oral, Combined; D007376:Interleukin-2; D008934:Mitogens; D060749:alpha-2-HS-Glycoprotein