[In vitro antifungal activities of amorolfine against fresh isolates from patients with cutaneous mycosis].
In vitro antifungal activities of amorolfine (MT-861), a new morpholine antifungal agent, were examined using an agar-dilution method, in comparison with those of 2 other antifungal agents, clotrimazole (CTZ) and bifonazole (BFZ), against 182 clinical isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, and Epidermophyton floccosum, which had been freshly isolated from a total of 182 cutaneous mycotic patients with various types of dermatophytes or cutaneous candidiasis. Antifungal activities of the 3 drugs against T. rubrum were in the order of MT-861 greater than CTZ greater than BFZ, with the lowest average MIC values (0.0070 micrograms/ml) obtained with MT-861. The average MIC value of MT-861 for clinical isolates from patients with pedis was roughly 2.3-fold higher than that for those from patients with tinea corporis. Out of 3 drugs tested MT-861 exhibited the most potent activities against clinical isolates of T. mentagrophytes, M. canis, and E. floccosum with average MIC values of 0.0267, 0.0079, and 0.0018 micrograms/ml, respectively. MIC values of MT-861 against isolates of Candida albicans ranged from 0.01 to 10 micrograms/ml, and the average value (0.1762 micrograms/ml) was the lowest of the 3 drugs.
Uchida
K
K
Teikyo University Research Center for Medical Mycology.
Aoki
K
K
Yamaguchi
H
H
D000935:Antifungal Agents / Q000494:pharmacology*; D003022:Clotrimazole / Q000494:pharmacology; D003881:Dermatomycoses / Q000382:microbiology*; D005658:Fungi / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009025:Morpholines / Q000494:pharmacology*
D000935:Antifungal Agents; D007093:Imidazoles; D009025:Morpholines; C038974:amorolfine; D003022:Clotrimazole; C036596:bifonazole