Effects of aluminium salts on synaptosomal enzymes--an in vitro kinetic study.
Synaptosomal key enzymes, ATPase (Na(+)-K+, Mg2+ and Ca2+ dependent) and AchE, were used as probes to compute IC50-values in order to study neurochemical effects of aluminium salts. Such effects were examined by means of the Toxicity Test Value (TTV), Maximum Chemical Acceptability Value (MCAV) and Omega (omega) value which indicated salt specific toxicity. Kinetics of Ca2(+)-ATPase inhibition by AlF3 was found to be non-competitive.
Rao
K S
KS
Department of Nutrition and Food Safety, Central Food Technological Research Institute, Mysore, India.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000534:Alum Compounds / Q000633:toxicity*; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D002800:Cholinesterase Inhibitors / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology*; D013696:Temperature
D000534:Alum Compounds; D002800:Cholinesterase Inhibitors; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase