Prognostic significance of the evaluation of bronchoalveolar lavage cell populations in patients with HIV-1 infection and pulmonary involvement.
To investigate the prognostic utility of the morphologic and immunologic evaluation of BAL cell populations in determining mortality risk, we analyzed BAL data obtained from 115 patients infected with HIV-1. Forty fatal outcomes occurred within 73 patients with OI. The OI patients who died showed a significant increase in neutrophils with respect to surviving patients. Furthermore, the finding of a BAL neutrophilia in HIV-1-infected patients with OI strongly correlated with a high risk of death. Among 42 cases without OI, 11 patients died. Patients without OI who had a fatal outcome showed an increase in CD3+ and CD8+ BAL lymphocytes with respect to the survivors. The presence of a lymphocytic alveolitis was associated with a significant increase in the mortality rate. Taken together our data suggest that the evaluation of the BAL cell populations might be useful in predicting the risk of fatal outcome in patients with HIV-1 infection.
Agostini
C
C
Padua University School of Medicine, Department of Clinical Medicine, Italy.
Zambello
R
R
Trentin
L
L
Poletti
V
V
Spiga
L
L
Gritti
F
F
Cipriani
A
A
Salmaso
L
L
Cadrobbi
P
P
Semenzato
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000401:mortality; D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D005260:Female; D006098:Granulocytes / Q000473:pathology; D015497:HIV-1; D006801:Humans; D016131:Lymphocyte Subsets; D016676:Macrophages, Alveolar / Q000473:pathology; D008297:Male; D009894:Opportunistic Infections / Q000150:complications* / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012141:Respiratory Tract Infections / Q000150:complications* / Q000473:pathology*; D012680:Sensitivity and Specificity