title: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): diagnosis by fine-needle aspiration.
abstract: Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare idiopathic proliferative disorder of histiocytes with characteristic morphologic features. We describe a case of SHML occurring in a 14-yr-old black male, in whom the diagnosis was made by fine-needle aspiration of a cervical lymph node. Cytologic features included increased numbers of large histiocytes associated with a polymorphous, cellular background composed of benign lymphocytes, plasma cells, and polymorphonuclear leukocytes. Lymphophagocytosis was a prominent feature. Extranodal involvement of the larynx was documented by surgical biopsy; there was no other extranodal disease. One year after diagnosis, the patient is clinically well, with no residual lymphadenopathy.
authors.affiliation: Department of Pathology, Hennepin County Medical Center, Minneapolis, MN 55415.
authors.forename: B C
authors.initials: BC
authors.lastname: Trautman
authors.forename: M W
authors.initials: MW
authors.lastname: Stanley
authors.forename: G S
authors.initials: GS
authors.lastname: Goding
authors.forename: J
authors.initials: J
authors.lastname: Rosai
mesh_terms: D000293:Adolescent; D001707:Biopsy, Needle; D015618:Histiocytosis, Sinus / Q000150:complications* / Q000473:pathology*; D006801:Humans; D007818:Laryngeal Diseases / Q000209:etiology* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009333:Neck