title: Influence of calcium channel blockers on pentylenetetrazol and electroshock-induced convulsions in mice.
abstract: Nifedipine (2.5-10 mg/kg) and verapamil (2.5 and 10 mg/kg) offered some protection against pentylenetetrazol (100 and 130 mg/kg)-induced seizure activity in mice. No protection was provided by diltiazem (1.25-10 mg/kg) in this model of experimental epilepsy. Repeated administration of calcium channel blockers (CCBs) in doses of 5 and 10 mg/kg twice daily for three days resulted in no protective effect against pentylenetetrazol. Regarding electroconvulsions, nifedipine (2.5-10 mg/kg) showed the best anticonvulsive action--for instance, in the dose of 10 mg/kg (60 min--treatment time) it elevated the threshold for electroconvulsions from 7.1 to 10.5 mA. Diltiazem (up to 10 mg/kg) and verapamil (up to 20 mg/kg) were considerably less potent in this respect. After repeated administration, only nifedipine (5-10 mg/kg) retained its protective action against electroconvulsions.
authors.affiliation: Department of Pharmacology, Medical Academy, Lublin, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
authors.forename: S J
authors.initials: SJ
authors.lastname: Czuczwar
authors.forename: A
authors.initials: A
authors.lastname: Chodkowska
authors.forename: J
authors.initials: J
authors.lastname: Szponar
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology; D004597:Electroshock; D005260:Female; D051379:Mice; D009543:Nifedipine / Q000494:pharmacology; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D014700:Verapamil / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine; D010433:Pentylenetetrazole