title: Immune modulation by Ostertagia ostertagi and the effects of diet.
abstract: IgG1 antibody responses to Ostertagia ostertagi third stage larvae (L3) and the third party antigen, keyhole limpet haemocyanin (KLH), and faecal egg counts were determined in calves infected with a single dose of O. ostertagi and in uninfected, pair-fed calves. The infected and uninfected calves were given diets either high (H) or low (L) in protein and energy. The diets were within the normal range of husbandry practice in the UK. IgG1 antibody responses to L3 antigen were significantly greater from 6 weeks post-infection in infected calves given the L diet than in infected calves given the H diet (P less than 0.05). The effects of diet and infection on anti-KLH IgG1 responses were independent of each other. IgG1 responses to KLH were decreased by infection and by the L diet compared with the H diet.
authors.affiliation: Department of Veterinary Pathology, University of Liverpool, UK.
authors.forename: M M
authors.initials: MM
authors.lastname: Mansour
authors.forename: T G
authors.initials: TG
authors.lastname: Rowan
authors.forename: J B
authors.initials: JB
authors.lastname: Dixon
authors.forename: S D
authors.initials: SD
authors.lastname: Carter
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D000941:Antigens / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004435:Eating; D002149:Energy Intake; D005243:Feces / Q000469:parasitology; D006433:Hemocyanins / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008297:Male; D010028:Ostertagia / Q000276:immunology; D010029:Ostertagiasis / Q000276:immunology / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D015430:Weight Gain
chemical_list: D000909:Antibodies, Helminth; D000941:Antigens; D004044:Dietary Proteins; D007074:Immunoglobulin G; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin