[Tissue-specific blocking of the EcoRI site adjacent to the pseudogene for mouse oncoprotein p53].
EcoRI fragments of DNA isolated from the different mouse organs were hybridized to radioactivity labelled probe specific for the gene of oncoprotein p53. The analysis of the blot-hybridization points to the existence of the specific blockage of an EcoRI site flanking a 3.3 kb fragment of DNA including the pseudogene p53, isolated from the skin tissue. The existence of a polymorphous EcoRI site localized distally to the pseudogene p53 has been demonstrated in the DNA of mice of different lines.
Ninkina
N N
NN
Bukhman
V L
VL
Samarina
O P
OP
Chumakov
P M
PM
D000818:Animals; D015246:Deoxyribonuclease EcoRI / Q000235:genetics*; D008099:Liver / Q000201:enzymology; D051379:Mice; D015513:Oncogene Proteins / Q000235:genetics*; D009928:Organ Specificity; D010750:Phosphoproteins / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011544:Pseudogenes; D015183:Restriction Mapping; D012867:Skin / Q000201:enzymology; D016159:Tumor Suppressor Protein p53
D015513:Oncogene Proteins; D010750:Phosphoproteins; D016159:Tumor Suppressor Protein p53; D015246:Deoxyribonuclease EcoRI
Tkanespetsificheskoe blokirovanie EcoRI-saĭta vblizi psevdogena onkobelka p53 myshi.