Effects of neurotropic agents with a selectivity for alpha-adrenoceptors on nitrile-induced dyskinetic syndrome in mice.
Allylnitrile, crotononitrile and 2-pentenenitrile induce this behavioral syndrome, which includes persistent random circling, head twitching and backward running. The effects of neurotropic agents, with a selectivity for the alpha 1 or alpha 2 adrenoceptor, were examined on the nitrile-induced behavioral abnormalities. The alpha 1 agonist phenylephrine, the alpha 2 agonist clonidine and the alpha 1 antagonist prazosin, inhibited the behavioral syndrome induced by each nitrile, while the alpha 2 antagonist yohimbine had no effect. These results suggest that the noradrenergic system may be involved in the manifestation of the syndrome. Furthermore, a tonic noradrenergic influence on subcortical systems may be required for the syndrome to occur.
Tanii
H
H
Department of Hygiene, School of Medicine, Kanazawa University, Japan.
Hayashi
M
M
Hashimoto
K
K
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D003000:Clonidine / Q000494:pharmacology / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D051379:Mice; D009570:Nitriles / Q000633:toxicity*; D010656:Phenylephrine / Q000494:pharmacology / Q000627:therapeutic use; D011224:Prazosin / Q000494:pharmacology / Q000627:therapeutic use; D015016:Yohimbine / Q000494:pharmacology / Q000627:therapeutic use
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D009570:Nitriles; D010656:Phenylephrine; D015016:Yohimbine; D003000:Clonidine; D011224:Prazosin