title: Angiotensin and sodium interaction in the organum cavum pre-lamina terminalis: electrophysiological and drinking responses.
abstract: Recording from single neurons in the rostral juxta-cerebroventricular areas, previous investigations in this laboratory failed to find neurons responding to iontophoretic application of both angiotensin II and Na+ in an additive or in a synergistic way. We are now describing such neurons found along the walls of the organum cavum pre-lamina terminalis (O.C.P.L.T.), a recently described structure. In another experiment, angiotensin II microinjections into this hollow O.C.P.L.T. in freely moving rats elicited drinking responses that were blocked whenever the vehicle contained no Na+. Although a critical concentration of Na+ seems to play a permissive role in the dispogenic action of angiotensin within the O.C.P.L.T., various concentrations of NaCl with angiotensin II did not alter the drinking response to angiotensin II itself, and hypertonic NaCl was not dipsogenic by itself in this area.
authors.affiliation: C.N.R.S.-I.N.S.E.R.M., Laboratoire de Neurobiologie des Régulations, College de France, Paris.
authors.forename: S
authors.initials: S
authors.lastname: Nicolaïdis
authors.forename: M
authors.initials: M
authors.lastname: el Ghissassi
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002552:Cerebral Ventricles; D004326:Drinking / Q000187:drug effects / Q000502:physiology*; D004347:Drug Interactions; D004594:Electrophysiology; D004805:Ependyma / Q000187:drug effects* / Q000502:physiology; D007276:Injections, Intraventricular; D051381:Rats; D012964:Sodium / Q000494:pharmacology*
chemical_list: D000804:Angiotensin II; D012964:Sodium