title: Isoniazid resistant tuberculosis in a school outbreak: the protective effect of BCG.
abstract: An outbreak of isoniazid resistant tuberculosis occurred in a large second level school. A total of 1,160 teenage pupils were at risk. Nineteen cases of tuberculosis were diagnosed, 15 were students, 9 of whom were among 251 non-vaccinated students and 6 among 909 vaccinated students. Two cases of miliary tuberculosis, one of whom also had tuberculous (TB) meningitis, occurred in the non-vaccinated group. The number of children with Heaf grade +3 or +4 was significantly greater among children who had been given Bacille Calmette-Guérin (BCG) vaccination (8 vs 4.4%). This suggests a boosting effect on the response in vaccinated children. The protective effect of neonatal BCG vaccination in this school outbreak suggests that it provides significant protection against tuberculosis lasting into adolescence.
authors.affiliation: North Western Health Board, Co. Donegal, Ireland.
authors.forename: A
authors.initials: A
authors.lastname: Shannon
authors.forename: P
authors.initials: P
authors.lastname: Kelly
authors.forename: M
authors.initials: M
authors.lastname: Lucey
authors.forename: M
authors.initials: M
authors.lastname: Cooney
authors.forename: P
authors.initials: P
authors.lastname: Corcoran
authors.forename: L
authors.initials: L
authors.lastname: Clancy
mesh_terms: D000293:Adolescent; D000328:Adult; D001500:BCG Vaccine / Q000627:therapeutic use*; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000517:prevention & control*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D007538:Isoniazid / Q000494:pharmacology*; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011641:Public Relations; D012574:Schools; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*
chemical_list: D001500:BCG Vaccine; D007538:Isoniazid