[Beta-N-acetylglucosaminidase (beta-NAG) as a parameter in the diagnosis and evaluation of primary glomerular and tubulointerstitial kidney diseases].
beta-N-acetylglucosaminidase (beta-NAG) and beta 2-microglobulin were assessed in two cohorts of patients with glomerular or tubulointerstitial diseases respectively. While beta-NAG activities did not differ statistically significantly between both groups, beta 2-microglobulin excretion was statistically highly significantly increased in the setting of tubulointerstitial diseases. On the whole mean beta-NAG activity at 37 degrees C and beta 2-microglobulin urinary excretion were elevated in both groups, when compared to normal controls. Increased beta-NAG activities above 10 U/g creatinine were associated with a marked increase of creatinine serum levels within 6 months in both, patients with glomerular and tubulointerstitial basic renal diseases. beta-NAG and beta 2-microglobulin are useful tools in diagnosis and assessment of renal diseases elucidating different aspects.
Hauser
A C
AC
1. Medizinische Universitätsklinik, Wien.
Fabrizii
V
V
Derfler
K
K
Balcke
P
P
D000118:Acetylglucosaminidase / Q000652:urine*; D003404:Creatinine / Q000097:blood; D003937:Diagnosis, Differential; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000201:enzymology; D006801:Humans; D007677:Kidney Function Tests; D009395:Nephritis, Interstitial / Q000175:diagnosis* / Q000201:enzymology; D011379:Prognosis; D001613:beta 2-Microglobulin / Q000652:urine
D001613:beta 2-Microglobulin; D003404:Creatinine; D000118:Acetylglucosaminidase
Beta-N-Acetylglucosaminidase (beta-NAG) als Parameter in der Diagnose und Bewertung von primär glomerulären und primär tubulointerstitiellen Nierenerkrankungen.