title: Calorimetric analysis of microbial growth: with special reference to quantitative evaluation of drug action.
abstract: Our research method for the calorimetric characterization of the biological effects of drugs and other chemicals on metabolic activities of living cells is outlined. The effects of various substances on different microbial systems were studied quantitatively using a calorimeter, and the results were used to plot drug potency curves for each drug. The method was also used to study microbial activity in soil. It was found to be a useful technique for the quantitative characterization of pollutants in ecological systems.
authors.affiliation: Laboratory of Biophysical Chemistry, College of Agriculture, University of Osaka Prefecture, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001236:Aspergillus oryzae / Q000254:growth & development* / Q000502:physiology; D001833:Body Temperature Regulation; D002151:Calorimetry; D004043:Dietary Fiber; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development* / Q000502:physiology; D005520:Food Preservatives / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D009675:Novobiocin / Q000494:pharmacology; D009994:Osmolar Concentration; D010226:Parabens / Q000494:pharmacology; D012044:Regression Analysis; D012987:Soil
chemical_list: D000900:Anti-Bacterial Agents; D004043:Dietary Fiber; D005520:Food Preservatives; D010226:Parabens; D012987:Soil; D009675:Novobiocin; D005947:Glucose; C038193:4-hydroxybenzoic acid