Bandage contact lens augmentation of 5-fluorouracil treatment in glaucoma filtration surgery.
The use of 5-Fluorouracil (5-FU) to inhibit scarring following filtration surgery has been hampered by corneal epithelial defects and their accompanying inflammation. This toxicity, which occurs during the crucial period in which the risk of bleb failure is highest, has previously been a relative contraindication to further 5-FU use. We have found the early placement of a therapeutic bandage contact lens permits extended administration of 5-FU during this period, minimizing discomfort and inflammation as well as enhancing bleb survival.
Beckman
R L
RL
New England Glaucoma Research Foundation, Boston, MA 02114.
Sofinski
S J
SJ
Greff
L J
LJ
Oates
D C
DC
Smith
T J
TJ
Simmons
R J
RJ
D000368:Aged; D002387:Cataract Extraction; D003261:Contact Lenses; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D012086:Reoperation; D014130:Trabeculectomy
D005472:Fluorouracil