Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.
Inflammatory myopathy has been associated with systemic inflammatory processes, endocrinopathies, malignancies and infections. Drug induced myopathies have been implicated with the use of several medications. We report a case of biopsy proven myositis whose symptoms began within 10 days of receiving leuprolide acetate therapy for prostate cancer. Drug withdrawal and brief steroid therapy resulted in clinical remission within two months of diagnosis.
Crayton
H
H
Department of Medicine, University of Wisconsin Hospital and Clinics, Madison 53792.
Bohlmann
T
T
Sufit
R
R
Graziano
F M
FM
D000368:Aged; D001706:Biopsy; D006801:Humans; D016729:Leuprolide / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000473:pathology / Q000648:ultrastructure; D009220:Myositis / Q000139:chemically induced*; D011471:Prostatic Neoplasms / Q000188:drug therapy*
D016729:Leuprolide