Pregnancy-associated aplastic anemia--report of 3 cases.
3 patients with pregnancy-associated aplastic anemia are reported. Management throughout most of the pregnancy consisted of supportive care. In 2 patients an improvement in blood counts occurred after delivery and, in 1 of these, the pancytopenia recurred during a subsequent pregnancy. In 1 case no improvement occurred after delivery and the patient ultimately required an allogeneic bone marrow transplantation. The outcome of these 3 cases demonstrates that pregnancy-associated aplastic anemia can be managed successfully. The improvement that often occurs after delivery suggests a pathogenetic role for pregnancy in the development of this disease.
van Besien
K
K
Division of Hematology/Oncology, Indiana University Medical School, Indianapolis.
Tricot
G
G
Golichowski
A
A
Padilla
L
L
Hoffman
R
R
D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood* / Q000209:etiology / Q000628:therapy; D001772:Blood Cell Count; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007743:Labor, Obstetric; D010976:Platelet Count; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000628:therapy
D006454:Hemoglobins