title: A reinterpretation of the events in gastric carcinogenesis.
abstract: It is proposed here that the initial events in gastric carcinogenesis occur at the junction of the oxyntic and antral mucosae. Intestinal metaplasia represents an adaptive counter-response to early neoplastic change at this site. Chronic gastric ulceration may arise due to the elimination of overtly dedifferentiated cells at a later stage in the evolution of the neoplastic process. Intestinal type gastric carcinoma possibly represents breakthrough past these mechanisms.
authors.affiliation: School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Seery
mesh_terms: D000818:Animals; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D008679:Metaplasia; D008954:Models, Biological; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology; D013276:Stomach Ulcer / Q000150:complications / Q000473:pathology