title: Early termination of pregnancy: medical induction with prostaglandins versus surgical aspiration under local anesthetic.
abstract: Termination of pregnancy at 4-8 weeks gestation in 1085 patients using either local prostaglandin instillation (n = 820) or uterine aspiration under local anesthetic (n = 265) have been analyzed. Morbidity for both methods was similar although the incidence of side-effects (0.4%) and the transfusion rate (0%) were lower after aspiration than the respective rates of 59% and 1.3% after prostaglandin treatment. However the rates of genital tract trauma (0.75%) and uterine sepsis (1.8%) after aspiration were higher than the respective rates of 0.3% and 0.9% after prostaglandin treatment. The major disadvantage of prostaglandin treatment was the rate of re-admission for evacuation (8.5%) compared with (0.9%) after aspiration, although patient acceptability for both techniques was similar. In view of the advantages, more widespread use of both methods of termination is indicated.
authors.affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, UK.
authors.forename: N C
authors.initials: NC
authors.lastname: Hill
authors.forename: I Z
authors.initials: IZ
authors.lastname: MacKenzie
mesh_terms: D000028:Abortion, Induced / Q000379:methods* / Q000523:psychology; D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D003258:Consumer Behavior; D004107:Dilatation and Curettage / Q000009:adverse effects*; D004739:England / Q000453:epidemiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015994:Incidence; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011453:Prostaglandins / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014592:Uterine Hemorrhage / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D014619:Vacuum Curettage / Q000009:adverse effects*
chemical_list: D011453:Prostaglandins