Quinine and quinidine cross-react after systemic photosensitization in the mouse.
Using a protocol for induction of photoallergy in the mouse after systemic administration, quinine was shown to be just as potent a photosensitizer as its d-isomer, quinidine. The dose-response curves for the two isomers followed a similar course both for induction and elicitation. Cross-reaction experiments, where induction and challenge were performed with different isomers, indicated that quinine and quinidine cross-react. Traces of the isomer as a contaminant in the test compound are not likely to account for this cross-reactivity. For practical purposes, photosensitization to one of these two quinoline methanol isomers seems to exclude the future use of the other.
Wirestrand
L E
LE
Department of Dermatology, Lund University, Malmö General Hospital, Sweden.
Ljunggren
B
B
D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D007274:Injections, Intraperitoneal; D051379:Mice; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D011802:Quinidine / Q000008:administration & dosage / Q000494:pharmacology*; D011803:Quinine / Q000008:administration & dosage / Q000494:pharmacology*; D014466:Ultraviolet Rays
D003520:Cyclophosphamide; D011803:Quinine; D011802:Quinidine