title: Reduction of diabetes incidence in NOD mice by neonatal glucose treatment.
abstract: The aim of this study was to investigate whether neonatal glucose treatment influences the incidence of diabetes in NOD mice. Thirty-nine NOD mice (19 males, 20 females) were treated with 8 g glucose/kg BW/day administered by subcutaneous injections twice a day for the first six days of life. Thirty-six untreated NOD mice (20 males, 16 females) served as a control group. In the glucose-treated group, 33% became diabetic compared with 58% in the control group (X2 = 5.3, p = 0.021). Among the glucose-treated males, 16% became diabetic compared with 50% of the untreated males (X2 = 5.5, p = 0.019), whereas 50% of the glucose-treated females became diabetic compared with 69% of the untreated females (X2 = 1.1, NS). We conclude that neonatal glucose treatment can reduce the diabetes incidence in NOD mice. These results could have implications for the prevention of type 1 diabetes mellitus in humans.
authors.affiliation: Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Bock
authors.forename: T W
authors.initials: TW
authors.lastname: Kjaer
authors.forename: M
authors.initials: M
authors.lastname: Jørgensen
authors.forename: K
authors.initials: K
authors.lastname: Josefsen
authors.forename: J
authors.initials: J
authors.lastname: Rygaard
authors.forename: K
authors.initials: K
authors.lastname: Buschard
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D010179:Pancreas / Q000473:pathology
chemical_list: D005947:Glucose