D-aspartate oxidase activity and D-aspartate content in a mutant mouse strain lacking D-amino acid oxidase.
A mutant mouse strain ddY/DAO- lacks D-amino acid oxidase activity and accumulates free neutral D-amino acids in its tissues. In this study, D-aspartate oxidase activity and D-aspartate content in the tissues of these mutant mice were compared with those of normal mice. No significant difference was observed, indicating that the metabolism of acidic D-amino acids was unaffected in the mutant.
Nagasaki
H
H
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
Yamada
R
R
Konno
R
R
Yasumura
Y
Y
Iwashima
A
A
D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D001921:Brain / Q000201:enzymology; D003605:D-Amino-Acid Oxidase / Q000172:deficiency*; D050804:D-Aspartate Oxidase; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains
D001224:Aspartic Acid; D000594:Amino Acid Oxidoreductases; D050804:D-Aspartate Oxidase; D003605:D-Amino-Acid Oxidase