title: Toxigenics.
abstract: Toxigenes are artificial genes created through genetic engineering which produce a native or modified toxin under the control of a tissue- or developmental-stage specific regulatory element. The toxigene is usually designed to make a gene product which, when produced intracellularly, leads to cell death or 'suicide'. The implantation and expression of toxigenes in transgenic animals may lead to cell-specific ablation which can be used to study developmental cell lineages and to create animal models of degenerative diseases.
authors.affiliation: Molecular Genetics Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
authors.forename: G A
authors.initials: GA
authors.lastname: Evans
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D015870:Gene Expression; D005818:Genetic Engineering; D000922:Immunotoxins / Q000235:genetics*; D011994:Recombinant Proteins
chemical_list: D000922:Immunotoxins; D011994:Recombinant Proteins