Cytogenetics of renal cell carcinomas associated with von Hippel-Lindau disease.
To establish the chromosome pattern, we have analyzed short-term cultures of 24 renal cell carcinomas (RCC) from four patients with von Hippel-Lindau disease (VHL). We evaluated the results together with those for 16 RCCs from two VHL patients karyotyped previously in our laboratory and those of 6 tumors published by others. In all 46 RCCs, the cells had lost the shortest overlapping region of the 3pl3-pter chromosome segment. The rearrangement of 3p was the only karyotype change in 20 tumors. In more than 50% of the tumors, a gain of the shortest overlapping region of the 5122-qter segment was detected. Comparative analysis showed that the chromosome aberrations in RCCs associated with VHL are similar to those found in sporadic RCCs. These results indicate that non-papillary sporadic and VHL-RCCs have common genetic mechanisms that result in the loss of the 3p13-pter region containing one or more putative suppressor genes.
Kovacs
G
G
Biological Carcinogenesis and Development Program, Program Resources, Inc./DynCorp, Frederick, Maryland.
Emanuel
A
A
Neumann
H P
HP
Kung
H F
HF
D000782:Aneuploidy; D014408:Biomarkers, Tumor / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D002893:Chromosomes, Human, Pair 3 / Q000648:ultrastructure; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics*; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D014178:Translocation, Genetic; D006623:von Hippel-Lindau Disease / Q000235:genetics*
D014408:Biomarkers, Tumor; D005819:Genetic Markers