title: No involvement of alpha 2-adrenoceptors in the regulation of basal prolactin secretion in healthy men.
abstract: The role of alpha 2-adrenoceptors in the regulation of basal prolactin secretion was investigated in healthy male volunteers. Two independent, placebo-controlled, double-blind experiments were performed. In the first experiment, 50 micrograms dexmedetomidine (MPV-1440), a selective alpha 2-adrenoceptor agonist, and saline placebo were infused (IV) in five subjects. In the second experiment, 100 mg atipamezole (MPV-1248), a selective alpha 2-adrenoceptor antagonist, and saline placebo were infused in six volunteers. The concentrations of prolactin in plasma were not affected by the drugs. These results suggest that alpha 2-adrenoceptors do not a play significant role in the control of basal prolactin secretion in healthy men.
authors.affiliation: Department of Pharmacology, University of Turku, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Karhuvaara
authors.forename: A
authors.initials: A
authors.lastname: Kallio
authors.forename: M
authors.initials: M
authors.lastname: Koulu
authors.forename: H
authors.initials: H
authors.lastname: Scheinin
authors.forename: M
authors.initials: M
authors.lastname: Scheinin
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000328:Adult; D000704:Analysis of Variance; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D020926:Medetomidine; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000502:physiology; D012016:Reference Values
chemical_list: D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; D011942:Receptors, Adrenergic, alpha; C050701:atipamezole; D011388:Prolactin; D020926:Medetomidine