title: Autolysins are direct involved in the bactericidal effect caused by penicillin in wild type and in tolerant pneumococci.
abstract: The two pneumococcal autolytic enzymes (an N-acetylmuramoyl-L-alanine amidase and an endo-beta-1,4-N-acetylglucosaminidase) are directly involved in the penicillin-induced killing of Streptococcus pneumoniae. The activity of these lytic enzymes was efficiently controlled in tolerant mutants under physiological conditions.
authors.affiliation: Centro de Investigaciones Biológicas, C.S.I.C. Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: López
authors.forename: C
authors.initials: C
authors.lastname: Ronda
authors.forename: E
authors.initials: E
authors.lastname: García
mesh_terms: D000118:Acetylglucosaminidase / Q000235:genetics / Q000378:metabolism; D000483:Alleles; D001433:Bacteriolysis / Q000187:drug effects* / Q000235:genetics; D017038:Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; D009154:Mutation; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000235:genetics / Q000378:metabolism; D010403:Penicillin Resistance / Q000235:genetics; D010406:Penicillins / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics
chemical_list: D010406:Penicillins; D000118:Acetylglucosaminidase; D017038:Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; D009238:N-Acetylmuramoyl-L-alanine Amidase