[Immunologic studies in patients with ovarian carcinoma during radio-chemotherapy. I. Studies of lymphocyte subpopulations].
In this article we have studied the behaviours of different lymphocyte subpopulations (T11, T8, T4, B4 and B1) in the peripheral blood of 60 patients suffering from ovarian cancer during radio- and chemotherapy with the APAAP-technique. The most important results of our study are that compared with the chemotherapy the radiotherapy causes greater lymphocyte depression, that the subpopulations of T-lymphocyte with the exception of T8 show greater radio-sensitivities than B-lymphocyte, that T8-subpopulation is not radio-sensitive, and that the T11-, T4-, B4- and B1-subpopulations of the patients at stage I and II can recover from the depression caused by radiation much better than the corresponding subpopulations of the patients at stage III and IV.
Vahrson
H
H
Abteilung Gynäkologische Onkologie und Strahlentherapie, Justus-Liebig-Universität Giessen.
Li
L
L
Pralle
H
H
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016175:B-Lymphocyte Subsets / Q000528:radiation effects; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016131:Lymphocyte Subsets / Q000528:radiation effects; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000532:radiotherapy; D011379:Prognosis; D016176:T-Lymphocyte Subsets / Q000528:radiation effects
D000970:Antineoplastic Agents
Immunologische Untersuchungen bei Patientinnen mit Ovarialkarzinom unter Radio-Chemotherapie. Mitteilung I: Untersuchungen der Lymphozytensubpopulationen.