title: Imipramine and desipramine decrease the GABA-stimulated chloride uptake, and antigabaergic agents enhance their action in the forced swimming test in rats.
abstract: The present study reports that long-term (18 days) administration of imipramine (IMI, 20 mg/kg) or desipramine (DMI, 15 mg/kg) produced a significant decrease in the GABA-stimulated 36Cl- uptake into membrane vesicles from the cerebral cortex of rats (experiment 1). Experiments 2A, B show that anti-immobility effects of DMI and IMI (subacute treatment) in the forced swimming test are enhanced when a single subconvulsant injection of picrotoxin or pentylenetetrazol is administered to the animals concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action.
authors.affiliation: Department of Pharmacology and Psychiatry, School of Medicine, Autonomous University of Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Teruel
authors.forename: R M
authors.initials: RM
authors.lastname: Escorihuela
authors.forename: F
authors.initials: F
authors.lastname: Boix
authors.forename: B
authors.initials: B
authors.lastname: Longoni
authors.forename: M G
authors.initials: MG
authors.lastname: Corda
authors.forename: A
authors.initials: A
authors.lastname: Tobeña
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D002713:Chlorine; D003863:Depression / Q000378:metabolism*; D003891:Desipramine / Q000494:pharmacology*; D018756:GABA Antagonists; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D011868:Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D013550:Swimming; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D002712:Chlorides; D002713:Chlorine; D003891:Desipramine; D018756:GABA Antagonists; D007099:Imipramine; D010433:Pentylenetetrazole; D010852:Picrotoxin; D011868:Radioisotopes; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid