Parathyroid hormone secretion in diabetes mellitus.
To investigate the parathyroid function in diabetes mellitus, we performed an oral phosphate load in 6 diabetic patients and 6 nondiabetic subjects without renal failure (serum creatinine less than 1.5 mg/dl). Each subject received a total of 2.0 g of phosphate daily per os on 5 consecutive days. Blood and urine samples were obtained daily before and 2 h after the administration of phosphate in the morning. All subjects responded with a similar increase in the serum phosphorus concentration and fall in the ionized calcium concentration. Intact parathyroid hormone levels rose by 2.6-fold in the control subjects but by less than 1.5-fold in the diabetic subjects. It was concluded that hyporesponsiveness of the parathyroid hormone to phosphate administration was found in the diabetic patients without renal failure.
Kawagishi
T
T
Second Department of Internal Medicine, Osaka City University Hospital, Japan.
Morii
H
H
Nakatsuka
K
K
Sasao
K
K
Kawasaki
K
K
Miki
T
T
Nishizawa
Y
Y
D000368:Aged; D002117:Calcitriol / Q000502:physiology; D002118:Calcium / Q000097:blood; D003920:Diabetes Mellitus / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000378:metabolism*; D010710:Phosphates / Q000494:pharmacology; D010758:Phosphorus / Q000097:blood
D010281:Parathyroid Hormone; D010710:Phosphates; D010758:Phosphorus; D002117:Calcitriol; D002118:Calcium