title: A case of propylene glycol toxic reaction associated with etomidate infusion.
abstract: For the treatment of postoperative seizures and prevention of brain edema, an etomidate drip was used in conjunction with phenytoin, diazepam, pentobarbital, and phenobarbital in a 70-year-old woman. During a period of 24 hours, the patient received in excess of 479 g of propylene glycol, which was present at 35% (vol/vol) concentration in the undiluted etomidate. The propylene glycol toxic reaction resolved after the infusion was stopped.
authors.affiliation: Department of Medicine, Medical College of Virginia, Richmond 23298-0160.
authors.forename: E
authors.initials: E
authors.lastname: Bedichek
authors.forename: B
authors.initials: B
authors.lastname: Kirschbaum
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced*; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage; D001929:Brain Edema / Q000517:prevention & control; D004359:Drug Therapy, Combination; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D005045:Etomidate / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D014677:Pharmaceutical Vehicles; D011183:Postoperative Complications / Q000188:drug therapy; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000008:administration & dosage / Q000009:adverse effects*; D011559:Pseudotumor Cerebri / Q000188:drug therapy; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced*
chemical_list: D000927:Anticonvulsants; D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D019946:Propylene Glycol; D005045:Etomidate