Exaggerated natri-calci-uresis and increased circulating levels of parathyroid hormone and 1,25-dihydroxyvitamin D in patients with senile hypertension.
Renal handling of Na and Ca in response to physiological saline infusion (20 ml/kg i.v. for 2 h) was compared between 27 hypertensive (mean +/- SD age 79.8 +/- 9.2 years) and 44 normotensive (79.1 +/- 4.1 years) senile females. Compared to the normotensive group, the hypertensive group showed statistically significant decreases in the basal values of serum Ca and PRA, and significant increases in basal circulating levels of parathyroid hormone and 1,25(OH)2D and in urinary excretions of Na, Ca and Pi in the 2-hour urine specimens during the saline infusion. These results suggest that the excessive excretions of Ca and Pi associated with exaggerated natriuresis may participate in aberration of Ca metabolism in low-renin hypertensive seniles.
Morimoto
S
S
Department of Geriatric Medicine, Osaka University Medical School, Japan.
Imaoka
M
M
Kitano
S
S
Imanaka
S
S
Fukuo
K
K
Miyashita
Y
Y
Koh
E
E
Ogihara
T
T
D000042:Absorption; D000368:Aged; D002117:Calcitriol / Q000097:blood*; D002118:Calcium / Q000652:urine*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D009318:Natriuresis; D010281:Parathyroid Hormone / Q000097:blood*; D012964:Sodium / Q000378:metabolism
D010281:Parathyroid Hormone; D012964:Sodium; D002117:Calcitriol; D002118:Calcium