Gastric delivery system for iron supplementation.
A gastric delivery system (GDS) for iron supplementation was evaluated. Radioisotopic studies in 9 volunteers demonstrated a three-fold higher absorption of GDS iron compared with ferrous sulphate elixir. A double-blind placebo controlled trial was done in 200 women to compare the gastrointestinal side-effects associated with 50 mg iron daily given either as GDS or conventional ferrous sulphate. The conventional preparation was associated with a significantly higher frequency of nausea and anorexia, whereas there were no significant differences in reported side-effects between subjects receiving GDS or placebo. A single GDS capsule daily provides the same amount of absorbed iron as conventional ferrous sulphate given three times daily, and does not produce gastrointestinal side-effects.
Cook
J D
JD
Department of Medicine, Kansas University Medical Center, Kansas City 66103.
Carriaga
M
M
Kahn
S G
SG
Schalch
W
W
Skikne
B S
BS
D000284:Administration, Oral; D000328:Adult; D000747:Anemia, Hypochromic / Q000188:drug therapy*; D016009:Chi-Square Distribution; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D007504:Iron Radioisotopes; D008297:Male; D009325:Nausea / Q000139:chemically induced; D010349:Patient Compliance; D010865:Pilot Projects; D012720:Severity of Illness Index
D003692:Delayed-Action Preparations; D005296:Ferrous Compounds; D007504:Iron Radioisotopes; C020748:ferrous sulfate