Coronary vasomotion and coronary flow reserve during exercise.
Coronary vasomotion and coronary blood flow are important determinants of myocardial perfusion in patients with coronary artery disease. New digital angiographic techniques allow to study, not only the dimensions of a stenotic lesion (quantitative coronary arteriography), but also coronary flow reserve (parametric imaging). In a preliminary study both techniques were combined and coronary dimensions, as well as coronary flow reserve were determined in 15 patients (seven normals and eight patients with coronary artery disease) at rest, 45 s after 10 mg i.c. papaverine, during two levels of supine bicycle exercise, as well as 5 min after 1.6 mg sublingual nitroglycerin. Our results show that with modern digital subtraction techniques, not only stenosis geometry, but also coronary flow reserve can be determined at rest and during exercise conditions.
Hess
O M
OM
Department of Internal Medicine, University Hospital, Zürich, Switzerland.
Felder
L
L
Gaglione
A
A
Buechi
M
M
Vassalli
F
F
Jiang
Z
Z
Grimm
J
J
Krayenbuehl
H P
HP
D000328:Adult; D017023:Coronary Angiography / Q000379:methods*; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000503:physiopathology; D003329:Coronary Vasospasm / Q000000981:diagnostic imaging; D015444:Exercise; D006321:Heart / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D010208:Papaverine; D014666:Vasomotor System / Q000502:physiology*
D010208:Papaverine