title: Solitary Langerhans cell histiocytoma: an unusual form of Hashimoto-Pritzker histiocytosis?
abstract: A 2-month-old girl acutely developed a brownish, firm nodule on the left thigh. The lesion was surgically removed when the patient was age 3 months, and histology showed a massive dermal infiltration by large histiocytic cells with abundant ground glass cytoplasm. Most cells were S100 protein positive. Electron microscopic examination revealed the presence of Birbeck granules in about 30% of the histiocytes, as well as laminated dense bodies and wormlike bodies. No recurrence was observed during follow-up for three years. We believe that this case, like the one previously reported, represents a clinical variant of Hashimoto-Pritzker disease.
authors.affiliation: Clinique de Dermatologie, Hôpital Cantonal Universitaire, Geneva, Switzerland.
authors.forename: I
authors.initials: I
authors.lastname: Masouyé
authors.forename: P
authors.initials: P
authors.lastname: Chavaz
authors.forename: D
authors.initials: D
authors.lastname: Salomon
authors.forename: J
authors.initials: J
authors.lastname: Balderer
authors.forename: P
authors.initials: P
authors.lastname: Carraux
authors.forename: J H
authors.initials: JH
authors.lastname: Saurat
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006644:Histiocytes / Q000648:ultrastructure; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007223:Infant; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology
chemical_list: D009418:S100 Proteins