Comparative study of C reactive protein and serum amyloid A protein in experimental inflammation.
The responses of C reactive protein, measured by radial immunodiffusion and radioimmunoassay, and serum amyloid A protein, measured by radial immunodiffusion, were compared in eight subjects with inflammation induced experimentally by intradermal injection of monosodium urate crystals. A significant increase in serum amyloid A was noted after a lag phase of eight hours, the increase in median concentration at 48 hours being about eightfold. A parallel but less marked increase was found in C reactive protein when measured by radioimmunoassay (fourfold increase in median concentration at 48 hours) after a small but significant decrease during the lag phase. The changes in C reactive protein remained within the reference range and were not detectable by radial immunodiffusion.
Chambers
R E
RE
Department of Chemical Pathology, Bristol Royal Infirmary, United Kingdom.
Hutton
C W
CW
Dieppe
P A
PA
Whicher
J T
JT
D002097:C-Reactive Protein / Q000378:metabolism*; D006801:Humans; D005779:Immunodiffusion; D007249:Inflammation / Q000097:blood* / Q000139:chemically induced; D011863:Radioimmunoassay; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D014527:Uric Acid
D000685:Serum Amyloid A Protein; D014527:Uric Acid; D002097:C-Reactive Protein