title: The clinical significance of autoantibodies to soluble cellular antigens in systemic lupus erythematosus.
abstract: The relationships between autoantibodies to soluble cellular antigens and clinical features in systemic lupus erythematosus (SLE) were investigated in a large clinical-serological study. The absence of these precipitins in serum was associated with a low prevalence of vasculitis and membranous nephropathy (MGN). Other significant findings were the associations between nRNP antibody and Raynaud's phenomenon and MGN, SSB antibody and sicca complex, PCNA antibody and a young age at onset, and Bu antibody and an old age at onset. However, the most impressive findings were in DA1-positive patients which showed a unique prevalence of photosensitive skin lesions, lymphoadenopathy and hepatosplenomegaly. The present study confirms the usefulness of antibodies to soluble cellular antigens in the classification of patients with SLE.
authors.affiliation: Istituto di Clinica Medica I, Università degli Studi di Milano, Italia.
authors.forename: R
authors.initials: R
authors.lastname: Asero
authors.forename: E
authors.initials: E
authors.lastname: Bertetti
authors.forename: L
authors.initials: L
authors.lastname: Origgi
authors.forename: P
authors.initials: P
authors.lastname: Riboldi
authors.forename: C
authors.initials: C
authors.lastname: Zanussi
mesh_terms: D000293:Adolescent; D000328:Adult; D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D008181:Lupus Nephritis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011234:Precipitins / Q000276:immunology; D012995:Solubility; D014657:Vasculitis / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D011234:Precipitins