Sendai virus P gene produces multiple proteins from overlapping open reading frames.
The Sendai virus P gene contains overlapping open reading frames (ORFs), and several unusual mechanisms are used to produce multiple proteins from all three ORFs of this gene. These include the use of a non-AUG start codon, leaky ribosomal scanning, what appears to be scanning-independent ribosomal initiation and/or ribosomal jumping, and a form of mRNA editing.
Curran
J
J
Department of Microbiology, University of Geneva Medical School, Switzerland.
Kolakofsky
D
D
D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D015967:Gene Expression Regulation, Viral; D010222:Parainfluenza Virus 1, Human / Q000235:genetics*; D018184:Paramyxoviridae Infections / Q000235:genetics*; D010442:Peptide Chain Initiation, Translational / Q000235:genetics; D010750:Phosphoproteins / Q000235:genetics*; D016364:Reading Frames / Q000235:genetics*; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000235:genetics*
C055859:P protein, Sendai virus; D010750:Phosphoproteins; D014764:Viral Proteins; D012321:DNA-Directed RNA Polymerases