T-cell inducer populations in cutaneous inflammation: a predominance of T helper-inducer lymphocytes (THi) in the infiltrate of inflammatory dermatoses.
The mononuclear infiltrate found in a variety of inflammatory dermatoses was characterized by a predominance of T helper-inducer lymphocytes (THi), CD4+/CD45RA-/CD45RO+, a population of cells responsible for maintaining and promoting immune reactions. Only small numbers of T-suppressor-inducer lymphocytes (TSi), CD4+/CD45RA+/CD45RO-, cells responsible for inducing CD8 suppressor-effector cells to 'down regulate' immune reactions, were seen. The predominance of CD4+ THi lymphocytes was common to all dermatoses studied and suggests a common final pathway in chronic cutaneous inflammation, irrespective of initial causative factors.
Markey
A C
AC
Laboratory of Applied Dermatopathology, U.M.D.S., Guy's Hospital, London, U.K.
Allen
M H
MH
Pitzalis
C
C
MacDonald
D M
DM
D015496:CD4-Positive T-Lymphocytes; D003876:Dermatitis, Atopic / Q000276:immunology; D003877:Dermatitis, Contact / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008010:Lichen Planus / Q000276:immunology; D008179:Lupus Erythematosus, Discoid / Q000276:immunology; D011565:Psoriasis / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer