Serum IgD behaviour in HIV-1 infected patients.
From September 1987 to February 1990, repeated tests were performed in 325 HIV-1 infected subjects at different clinical stages using a radial immunodiffusion method to determine serum IgD behaviour in HIV-1 infection. Four patients had acute HIV-1 infection, 72 asymptomatic infection, 163 PGL, 49 ARC and 37 AIDS. During the study, 57 seropositive patients developed AIDS. The correlation between serum IgD and the clinical stage of HIV-1 infection, CD4+ and CD8+ lymphocyte levels, CD4+/CD8+ ratio, HIV-1 (p24) antigenemia and reactivity to core proteins, IgG, IgA, IgM isotypes and serum beta 2-microglobulin concentration. A significant correlation was noted between HIV-1 (p24) antigenemia, the disappearance of the antibodies reactivity to core proteins and IgD levels in ARC patients. A progressive increase of serum IgD before the occurrence of the symptomatic stage of HIV-1 infection was observed in HIV-1 infected patients who developed AIDS.
Raiteri
R
R
Department of Infectious Diseases, University of Turin, Italy.
Albonico
M
M
Deiana
R
R
Marietti
G
G
Sinicco
A
A
D000386:AIDS-Related Complex / Q000150:complications / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology; D000293:Adolescent; D000328:Adult; D005260:Female; D015483:HIV Antibodies / Q000276:immunology; D016655:HIV Core Protein p24 / Q000032:analysis; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007072:Immunoglobulin D / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012306:Risk; D016176:T-Lymphocyte Subsets; D001613:beta 2-Microglobulin / Q000032:analysis
D015483:HIV Antibodies; D016655:HIV Core Protein p24; D007072:Immunoglobulin D; D001613:beta 2-Microglobulin