Study of the metabolism of phenothiazines: determination of N-demethylated phenothiazines in urine.
When phenothiazine drugs (chlorpromazine, promazine, promethazine, propiomazine, propionylpromazine, trifluoperazine and trimeprazine) were reacted with m-chloroperbenzoic acid, N-demethylated phenothiazines were obtained in moderate yield. The mass spectra of the N-demethylated phenothiazines showed either m/z 44 and 72 or m/z 58 as characteristic ions depending on their side chain. The N-demethylated propiomazine was identified as a metabolite of propiomazine from the urine of a rat which was given propiomazine orally.
Choo
H Y
HY
Doping Control Center, Korea Institute of Science and Technology, Cheongryang, Seoul.
Shin
Y O
YO
Park
J
J
D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism / Q000652:urine*; D002723:Chlorobenzoates; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D010640:Phenothiazines / Q000378:metabolism / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
D014150:Antipsychotic Agents; D002723:Chlorobenzoates; D010640:Phenothiazines; C000433:3-chloroperbenzoic acid