Similar early gene responses to ligand-activated EGFR and neu tyrosine kinases in NIH3T3 cells.
We have compared the responses of serum-inducible immediate early genes to ligand activation of the epidermal growth factor receptor (EGFR) or a hybrid EGFR/neu receptor containing the intracellular domain of the neu proto-oncogene. Few differences in mRNA induction kinetics were found, emphasizing the functional similarity of these structurally related tyrosine kinases.
Koskinen
P
P
Department of Virology, University of Helsinki, Finland.
Lehväslaiho
H
H
MacDonald-Bravo
H
H
Alitalo
K
K
Bravo
R
R
D000818:Animals; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002678:Chimera; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D066246:ErbB Receptors / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects*; D007700:Kinetics; D051379:Mice; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes / Q000187:drug effects*; D012333:RNA, Messenger / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases; D014158:Transcription, Genetic
D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases