[The action of fenoptin on cAMP dynamics in the isolated guinea pig heart during contraction-relaxation].
The influence of finoptin and Ca2+ concentration decrease on cAMP dynamic during cardiac cycle in guinea pig isolated heart, activated by isadrin (3 x 10(-8) M), has been studied. In isadrin activation of adrenoceptors cAMP concentration increased by 50% during contraction and decreased during relaxation. Hypocalcium solution (0.15 mM) and finoptin decreased cAMP concentration and influenced its dynamic during cardiac cycle.
Laptev
B I
BI
Bardamova
I B
IB
Afanas'ev
S A
SA
Talaeva
E Iu
EIu
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002317:Cardiovascular Agents / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D014700:Verapamil / Q000494:pharmacology*
D002317:Cardiovascular Agents; C046978:phenoptin; D014700:Verapamil; D000242:Cyclic AMP; D002118:Calcium
Deĭstvie fenoptina na dinamiku tsAMF v izolirovannym serdtse morskoĭ svinki v protsesse ee sokrasheniia--rasslebleniia.