Structure and in vitro antiviral activity of sesquiterpene glycosides from Calendula arvensis.
Previous research on the aerial parts of Calendula arvensis led to the isolation of the epicubebol glycoside 1 and of the sesquiterpene glycosides 2-5 based on the alloaromadendrane skeleton. A further investigation has revealed two new glycosides, 6 and 7, derived from the same sesquiterpene, the structures of which were elucidated by spectral studies. Furthermore a series of antiviral tests has been performed on glycosides 1-7 by examining their ability to interfere with rhinovirus 1B and vesicular stomatitis virus infection in vitro. Only glycoside 1 slightly reduced rhinovirus multiplication. All the compounds were able to inhibit vesicular stomatitis virus infection, 1 and 2 being the most effective.
De Tommasi
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Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli, Italy.
Pizza
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Conti
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Orsi
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Stein
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D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification*; D002642:Chick Embryo; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D012229:Rhinovirus / Q000187:drug effects*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*
D000998:Antiviral Agents; D006027:Glycosides; D012717:Sesquiterpenes