[Importance of the histopathological type of the tumor as a parameter for recurrence and for prognosis of gastric cancers].
Importance of histopathological type of tumor for the prediction of recurrence and prognosis of gastric cancers was analysed in 4419 patients who underwent surgery in Aichi Cancer Center during the 23 years from 1965 to 1987. Correlation of initial recurrence site and the histology of the tumor was examined by the categorical discriminant analysis in 617 patients. Among these patients, 62% of liver metastasis was caused by well differentiated type cancers whereas 71% of peritoneal recurrence was poorly differentiated type cancers. Cox's regression tree type analysis was performed for 2893 cases with curative gastrectomy and the maximum difference in risk ratio was observed whether the tumor microscopically penetrated the serosal layer of the stomach. Difference of the prognosis due to histopathological type of the tumor appeared after correction of the s and n factors and in the early stages poorly differentiated type had better prognosis than well differentiated type cancers. On the contrary, in more advanced cases well differentiated type tumors had much better prognosis than poorly differentiated type cancers. From these results, we suggest that the consideration of histopathological type of the tumor should be implemented as an important parameter for the evaluation of prognosis of the gastric cancers.
Sakamoto
J
J
Department of Gastroenterological Surgery, Aichi Cancer Center, Nagoya, Japan.
Kito
T
T
Yamamura
Y
Y
Kojima
H
H
Nakazato
H
H
D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*