Development of non-Rh antibodies in volunteers stimulated for the production of hyperimmune anti-D.
At the North London Blood Transfusion Centre, red cells from accredited Rh-D-positive donors, matched for all antigens capable of inducing clinically significant antibodies, are used to stimulate immune plasma donors to achieve higher anti-D levels. Despite such careful matching, antibody to the relatively non-immunogenic M antigen developed in 3 out of 20 NN donors (15%) stimulated with M-positive cells. In general, good responders to the Rh antigen D are good responders to other red cell antigens; our report exemplifies the importance of using fully matched accredited red cells for immune stimulation and the need to perform thorough antibody screening after each stimulation.
Teesdale
P
P
North London Blood Transfusion Centre, UK.
de Silva
M
M
Contreras
M
M
D000917:Antibody Formation; D001782:Blood Donors; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D018029:Rho(D) Immune Globulin
D007518:Isoantibodies; C061961:RHO(D) antibody; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin