In-vitro effect of pirenzepine on motility of canine gall-bladder.
The action of pirenzepine as an antimuscarinic drug has been investigated on motor responses of muscle strips in the canine gall-bladder. Pirenzepine was further used to examine whether gall-bladder motor responses to synthetic sulphated cholecystokinin octapeptide (CCK-8) are sensitive to pirenzepine. Pirenzepine (10(-9)-10(-5) M) antagonized muscle contractions in response to acetylcholine (10(-9)-10(-2) M) and CCK-8 (10(-11)-10(-6) M) in a significant manner. These findings indicate that pirenzepine is a potent antagonist of two substances that are the principal contractile mediators of gall-bladder contraction and suggest that long-term administration of pirenzepine could contribute to stasis of the gall-bladder.
Pozo
M J
MJ
Faculty of Veterinary Science, Department of Physiology, University of Extremadura, Càceres, Spain.
Salido
M D
MD
Madrid
J A
JA
Salido
G M
GM
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004285:Dogs; D005704:Gallbladder / Q000187:drug effects*; D007537:Isometric Contraction; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010890:Pirenzepine / Q000494:pharmacology*; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology
D011976:Receptors, Muscarinic; D010890:Pirenzepine; D001285:Atropine; D002766:Cholecystokinin; D000109:Acetylcholine