Amperozide and conditioned behaviour in rats: potentiation by classical neuroleptics and alpha-methylparatyrosine.
Amperozide, a new putatively antipsychotic compound, has been evaluated for its effect on conditioned avoidance response and food-reinforced lever-pressing. Given alone, amperozide was almost equipotent to clozapine, but less potent than haloperidol in both test models. It was found that there was a statistically significant synergism, in these two models, between amperozide and classical neuroleptics. Since amperozide is inactive in behavioural tests reflecting striatal dopaminergic mechanisms, the synergistic effect could be of great therapeutic value in the treatment of psychotic disorders.
Egbe
P
P
Department of Pharmacology, University of Göteborg, Sweden.
Engel
J
J
Gustafsson
B
B
Christensson
E
E
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002090:Butyrophenones / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D005502:Food; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule; D019805:alpha-Methyltyrosine
D014150:Antipsychotic Agents; D002090:Butyrophenones; D008781:Methyltyrosines; D010879:Piperazines; D011619:Psychotropic Drugs; C049058:amperozide; D019805:alpha-Methyltyrosine; D003024:Clozapine; D006220:Haloperidol; C008522:metylperon; D002746:Chlorpromazine