Family data determine all parameters in Mendelian incomplete penetrance models.
We show that data on the frequency of occurrence of an hereditary trait in family members can be used to determine all four parameters in a Mendelian genetic model with incomplete penetrance. Thus previous statements in the literature that such data can determine only three combinations of the parameters are incorrect.
Whittemore
A S
AS
Department of Health Research and Policy, Stanford University School of Medicine, CA 94305-5092.
Keller
J B
JB
Ward
M J
MJ
D000483:Alleles; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D009679:Nuclear Family; D010641:Phenotype; D011336:Probability