Synthesis of a simplified transition-state analogue in an attempt to obtain an inhibitor of CMP-KDO synthetase.
The thioglycoside 5 of 3-deoxy-beta-D-manno-2-octulosonic acid (beta-KDO) has been synthesized in an attempt to make a simplified transition-state analogue inhibitor of the enzyme CMP-KDO synthetase (3-deoxy-D-manno-octulosonate cytidylyltransferase). Compound 5 was tested in vitro and was found to have no inhibitory activity.
Wåglund
T
T
Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Center, University of Uppsala, Sweden.
Claesson
A
A
D015394:Molecular Structure; D009713:Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013400:Sugar Acids / Q000138:chemical synthesis* / Q000494:pharmacology
D013400:Sugar Acids; C067944:3-deoxy-beta-manno-2-octulosonic acid thioglycoside; D009713:Nucleotidyltransferases; C028984:3-deoxy-manno-octulosonate cytidyltransferase