Metastatic renal cell carcinoma treated with purified leukocyte interferon. Clinical response in relation to tumor DNA content.
Twenty-eight patients with renal cell carcinoma and evaluable metastases were treated with a purified leukocyte interferon 2-7 x 10(6) IU daily. DNA content was analyzed by flow cytometry. Nine patients had lung metastases only, 12 had dissemination to lungs and to other sites as well, and 7 had metastases in other sites only. Two patients had complete response and one had minor response of lung metastases. Another 3 patients had mixed responses: 2 of them complete disappearance and one minor response of lung metastases but concomitant progression of skeletal and abdominal metastases. The overall response rate restricted to lung metastases only was 21% (6 of 28 patients) including the 3 patients with mixed response. The 6 patients with any kind of response were found among 19 patients with aneuploid primary tumors while no response was noted in 8 patients with diploid tumors.
Bengtsson
N O
NO
Department of Oncology, University of Umeå, Sweden.
Lenner
P
P
Sjödin
M
M
Hietala
S O
SO
Stenling
R
R
Lundgren
E
E
Ljungberg
B
B
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D004273:DNA, Neoplasm / Q000032:analysis*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D016019:Survival Analysis
D004273:DNA, Neoplasm; D016898:Interferon-alpha