title: Aristapedioid: a gain of function, homeotic mutation in Drosophila melanogaster.
abstract: The isolation of gain of function mutations has allowed the identification of a number of genes which are important in the normal development of the organism. We report here the isolation and characterization of Aristapedioid, a gain of function mutation which causes a partial transformation of arista towards tarsus and the loss or decrease in size of the dorso-central and scutellar bristles. Aristapedioid is the result of a P element mediated inversion which juxtaposes unrelated DNA adjacent to Suppressor 2 of zeste, causing a gain of function mutation in that gene.
authors.affiliation: Department of Biology, University of Virginia, Charlottesville 22901.
authors.forename: B P
authors.initials: BP
authors.lastname: Brunk
authors.forename: P N
authors.initials: PN
authors.lastname: Adler
mesh_terms: D000483:Alleles; D000818:Animals; D015139:Blotting, Southern; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D005801:Genes, Homeobox; D005816:Genetic Complementation Test; D008297:Male; D009154:Mutation; D010641:Phenotype; D015183:Restriction Mapping; D013489:Suppression, Genetic