Concurrent acute myeloid leukemia and systemic mastocytosis.
A 51-year-old woman presented with concurrent systemic mastocytosis and acute myeloid leukemia associated with a clonal karyotypic anomaly of t(8;21). Cytochemical, histologic, and cytogenetic studies helped in the distinction from a recently described entity: acute myeloid leukemia with marrow basophilia. Although the leukemia responded well to aggressive chemotherapy, the mastocytosis component worsened, illustrating the inherent resistance of mastocytosis to chemotherapy.
Wong
K F
KF
Institute of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Chan
J K
JK
Chan
J C
JC
Kwong
Y L
YL
Ma
S K
SK
Chow
T C
TC
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001491:Basophils / Q000473:pathology; D003582:Cytogenetics; D003937:Diagnosis, Differential; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008415:Mastocytosis / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged