title: A perspective on clinical research strategies in carcinoma of the large bowel.
abstract: Experience with screening for colorectal cancer has been disappointing. Prevention of this disease seems to be a more beneficial research direction. Although radical surgery presents the best treatment option, it is nonetheless an inadequate strategy by itself. A new dose intensive approach would temporally combine surgery and chemotherapy as a coordinated event. This would allow maximal cytoreduction over a minimal time period and little or no development of resistant cancer cells. This approach has resulted in a 75% projected 5 year survival in patients with peritoneal carcinomatosis from cystadenocarcinoma. Strategies for application of this cytoreductive approach in many patients with advanced gastrointestinal cancer are present.
authors.affiliation: Cancer Institute, Washington Hospital Center, Washington, D.C. 20010.
authors.forename: P H
authors.initials: PH
authors.lastname: Sugarbaker
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D012107:Research Design
chemical_list: D000970:Antineoplastic Agents