Atriopeptins are potent inhibitors of ACTH secretion by rat anterior pituitary cells in vitro: involvement of the atrial natriuretic factor receptor domain of membrane-bound guanylyl cyclase.
The current concept of the regulation of adenohypophysial corticotrophin secretion assigns a stimulatory role to neuropeptides of hypothalamic origin and an inhibitory function to adrenocortical glucocorticoid hormones. It has been shown that in isolated perifused rat anterior pituitary cells atriopeptins (1-28) and (5-28), but not (5-25), potently suppress corticotrophin secretion elicited by 41-residue corticotrophin-releasing factor and arginine vasopressin. The action of atriopeptins is associated with a marked increase in the cellular content of cyclic GMP. Moreover, 8-Br-cyclic GMP, a cell membrane permeant analogue of cyclic GMP, also inhibited secretagogue-stimulated corticotrophin release. It is suggested that atrio-peptins of hypothalamic and perhaps of cardiac origin may be functionally significant corticotrophin-release inhibiting factors.
Dayanithi
G
G
Department of Human Anatomy, University of Oxford.
Antoni
F A
FA
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D002478:Cells, Cultured; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000378:metabolism; D003864:Depression, Chemical; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D006162:Guanylate Cyclase / Q000378:metabolism; D010446:Peptide Fragments / Q000502:physiology; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000378:metabolism
D004232:Diuretics; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; C472610:atrial natriuretic peptide, rat; D001127:Arginine Vasopressin; C016276:8-bromocyclic GMP; D009320:Atrial Natriuretic Factor; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; C054538:atrial natriuretic factor (5-28); D006162:Guanylate Cyclase; D017461:Receptors, Atrial Natriuretic Factor; D006152:Cyclic GMP