Modification of silver-enhanced sodium transport across toad skin.
1. Silver stimulated short-circuit current and transepithelial potential difference. 2. Cysteine inhibited the silver-induced short-circuit current. 3. There was a dose-response inhibition of silver-induced short-circuit current by cysteine. 4. The silver-induced short-circuit current is carried by a net active sodium transfer from the outside to the inside bathing solution.
Gerencser
G A
GA
Department of Physiology, College of Medicine, University of Florida, Gainesville 32610.
Cornette
K M
KM
Loo
S Y
SY
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002024:Bufo marinus; D003545:Cysteine / Q000494:pharmacology; D004553:Electric Conductivity; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009994:Osmolar Concentration; D012834:Silver / Q000494:pharmacology*; D012867:Skin / Q000378:metabolism*; D012879:Skin Physiological Phenomena; D012964:Sodium / Q000493:pharmacokinetics*; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D013438:Sulfhydryl Compounds; D012834:Silver; D012964:Sodium; D003545:Cysteine