[Evaluation of modern therapy for neuroblastoma].
The clinical results were evaluated periodically in 50 cases of neuroblastoma, 4 survived cases out of 15 from 1965 to 1971, 6 survived of 16 (38%) from 1972 to 1982 and 11 survived of 19 (58%) after 1983. In the early period, before 1971, our systemic wide resection was not performed. From 1972, we operated on by our wide resection's technique which based on to preserve main vessels from tumor and lymph nodes. To separate the vessels from the lymph nodes was begun from both iliaca vessels to caeliac vessels. The systemic wide resection might contribute to improve survival rate from 1972 to 1982, however, all of 7 cases in stage IV did not survive. The best result after 1983, 58% survival rate, depends on new intensive chemotherapy accompanying with autologous bone marrow transplantation. All of 3 cases in stage III and 5 of 11 cases in stage IVA survived and better survival rates. Five alive cases in stage IVA received delayed wide resection after 3 or 4 cycles of new regimen A1, and then underwent bone marrow transplantation preconditioned by Melphalan .
Yokoyama
J
J
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
Hara
S
S
Kuroda
T
T
Hoshino
K
K
Tamura
T
T
Hosoya
R
R
Nishimura
K
K
D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000628:therapy*