title: Steroid therapy for bronchopneumonia in chronic granulomatous disease.
abstract: In general, immunosuppressive agents such as corticosteroids are considered to be a contraindication for immunocompromised hosts with an active infection. Recently, however, a few cases have been reported where the obstructive lesions caused by the excessive inflammation in chronic granulomatous disease were successfully resolved with corticosteroids, resulting in a remission of the infection. As we have also experienced a case in which oral corticosteroid used in combination with antibiotics had a beneficial effect on an intractable respiratory tract infection which occurred in a patient with chronic granulomatous disease, we present the case report. Although it may be very difficult to determine the candidates, we consider that in selected cases a corticosteroid therapy with concomitant use of antibiotics will be a choice for the treatment of intractable infections in chronic granulomatous disease.
authors.affiliation: Department of Pediatrics, Hokkaido University, School of Medicine, Sapporo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Narita
authors.forename: M
authors.initials: M
authors.lastname: Shibata
authors.forename: T
authors.initials: T
authors.lastname: Togashi
authors.forename: K
authors.initials: K
authors.lastname: Tomizawa
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
mesh_terms: D000293:Adolescent; D001996:Bronchopneumonia / Q000188:drug therapy* / Q000209:etiology; D002437:Cefazolin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*
chemical_list: D015378:Imipenem; D011239:Prednisolone; D002437:Cefazolin