Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder.
Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such patients.
McDougle
C J
CJ
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519.
Goodman
W K
WK
Price
L H
LH
Delgado
P L
PL
Krystal
J H
JH
Charney
D S
DS
Heninger
G R
GR
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D016666:Fluvoxamine; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D010091:Oximes / Q000627:therapeutic use*; D012569:Schizotypal Personality Disorder / Q000150:complications / Q000188:drug therapy; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D013981:Tic Disorders / Q000150:complications / Q000188:drug therapy
D014150:Antipsychotic Agents; D010091:Oximes; D012702:Serotonin Antagonists; D008094:Lithium; D016666:Fluvoxamine