[Clinical pharmacology of anticancer agents. (Part 1) Introduction, alkylating agents and platinum compounds].
Pharmacokinetic concepts as to absorption, distribution, metabolism and excretion of anticancer agents, and how drugs reach to the site of action were reviewed. Then, roles of the liver and kidney to the excretion and metabolism, intracellular pharmacokinetics, and relationships between drug response and cell proliferation kinetics or cell cycle phase were explained. Drug development, mode of action and pharmacokinetics of alkylating agents and platinum compounds were reviewed. This includes: alkylating agents: nitrogen mustard, phenylalanine mustard, estracyte, cyclophosphamide, carboquone, busulfan, nitrosourea, etc., and platinum compounds: cisplatin, carboplatin, 254-S, DWA-2114 R, NK-121.
Fujita
H
H
Dept. of Bacteriology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
D000477:Alkylating Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D002455:Cell Division; D002945:Cisplatin / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000378:metabolism
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D002945:Cisplatin