title: The eosinophilic granulocyte count in the respiratory secretions of children with chronic nonspecific respiratory diseases.
abstract: We performed cytologic evaluations of 6116 nasal and/or bronchial smears from 4510 patients (average age: 7.6 years; 3 months--17 years) suffering from different kinds of chronic nonspecific respiratory diseases (CNSRD); in 137 children (average age: 4.8 years) undergoing bronchologic examinations under general anesthesia we compared the findings with those for bronchoalveolar lavage (BAL). Nasal smears of 77 healthy children at a day care center (control group) were analysed four times per year for "significant secretory eosinophilia" (SEE; i.e. more than 13% eosinophils). We found: 1. Healthy children do not have such "SSE" in contrast to children with CNSRD who show different frequencies of "SSE" depending on the age of the child and the specific kind (diagnosis) of CNSRD. 2. 4.6% of infants (first year of life) were found to have SSE with a statistically significant correlation to increase in the following 10 years up to 50% of all children (p less than 0.001). 3. We found SSE in 4.41% of cases with relapsing bronchitis, in 7.14% (8.3% resp.) with chronic bronchitis, in 6.49% (9.2% resp.) with relapsing or chronic obstructive bronchitis and in 46.05% (55.3% resp.) with bronchial asthma (p less than 0.001). 4. The intensity of obstructive symptoms (nose: rhinitis; bronchus: dyspnoea) did not correlate with the number of eosinophils in the secretions. 5. Only the smear cytograms (nose/bronchus) enabled us to detect "SSE" whereas BAL cytograms were too insensitive (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Dept. of Pediatrics, Ernst-Moritz-Arndt-University Greifswald.
authors.forename: S
authors.initials: S
authors.lastname: Wiersbitzky
authors.forename: E H
authors.initials: EH
authors.lastname: Ballke
authors.forename: R
authors.initials: R
authors.lastname: Bruns
authors.forename: P
authors.initials: P
authors.lastname: Dammenhayn
authors.forename: S
authors.initials: S
authors.lastname: Winkler
authors.forename: H
authors.initials: H
authors.lastname: Wiersbitzky
authors.forename: F
authors.initials: F
authors.lastname: Heydolph
authors.forename: E
authors.initials: E
authors.lastname: Abel
authors.forename: U
authors.initials: U
authors.lastname: Dorn
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000473:pathology; D001980:Bronchi / Q000166:cytology; D001991:Bronchitis / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D002648:Child; D002675:Child, Preschool; D004804:Eosinophils; D005122:Exudates and Transudates / Q000166:cytology*; D006801:Humans; D007223:Infant; D008173:Lung Diseases, Obstructive / Q000473:pathology*; D009666:Nose / Q000166:cytology