title: Fenfluramine augmentation of clomipramine treatment of obsessive compulsive disorder.
abstract: Recently, much research interest has been directed to demonstrating a possible biological basis to obsessive compulsive disorder. In particular, dysregulation in brain serotonin is suggested to be important. Two cases are described in which fenfluramine, a presynaptic 5 HT-releasing agent and 5HT-reuptake inhibitor was used to augment clomipramine treatment for OCD.
authors.affiliation: University of Melbourne, Department of Psychiatry, Austin Hospital, Heidelberg, Vic.
authors.forename: F K
authors.initials: FK
authors.lastname: Judd
authors.forename: P
authors.initials: P
authors.lastname: Chua
authors.forename: C
authors.initials: C
authors.lastname: Lynch
authors.forename: T
authors.initials: T
authors.lastname: Norman
mesh_terms: D000328:Adult; D002997:Clomipramine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005277:Fenfluramine / Q000008:administration & dosage*; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000523:psychology* / Q000628:therapy*
chemical_list: D005277:Fenfluramine; D002997:Clomipramine