[The mechanism of the immunotropic effect of aspartic acid].
The effect of asparaginic acid to functional capacity on thymocytes was examined. We found that injection of 1 x 10(-4) g asparaginic acid during 5 days to rats with experimental iron result in an increase of incorporation of 3H-thymidine in thymocytes and proportion cAMP/cGMP in these cells being from 24.3 to 39.7. On the basis of these data we came to the conclusion that asparaginic acid activates immunocompetent cells following metabolic changes and asparaginic acid can be used as an immunotherapeutic agent, for example, in treatment of iron deficiency anaemia.
Bazarnyĭ
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Iastrebov
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AP
D000276:Adjuvants, Immunologic; D000747:Anemia, Hypochromic / Q000097:blood / Q000276:immunology; D000818:Animals; D001224:Aspartic Acid / Q000627:therapeutic use*; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008297:Male; D009942:Organometallic Compounds / Q000627:therapeutic use; D011134:Polysaccharides / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism
D000276:Adjuvants, Immunologic; D009942:Organometallic Compounds; D011134:Polysaccharides; C009766:ferrum lek; D001224:Aspartic Acid; D004247:DNA; D000242:Cyclic AMP; D006152:Cyclic GMP
K mekhanizmu immunotropnogo éffekta asparaginovoĭ kisloty.