A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.
The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.
Rosner
M H
MH
Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892.
Vigano
M A
MA
Ozato
K
K
Timmons
P M
PM
Poirier
F
F
Rigby
P W
PW
Staudt
L M
LM
D000595:Amino Acid Sequence; D001483:Base Sequence; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000235:genetics*; D015536:Down-Regulation; D004622:Embryo, Mammalian / Q000378:metabolism*; D004625:Embryo, Nonmammalian; D004707:Endoderm / Q000166:cytology; D015870:Gene Expression; D005801:Genes, Homeobox; D005854:Germ Cells / Q000378:metabolism*; D008648:Mesoderm / Q000166:cytology; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D050814:Octamer Transcription Factor-3; D009865:Oocytes / Q000254:growth & development / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D013234:Stem Cells / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D050814:Octamer Transcription Factor-3; D012333:RNA, Messenger; D014157:Transcription Factors