[How do beta receptor blockers modify physical performance and metabolism?].
Beta-blockers reduce physical capacity and lead to an increased sensation of muscular fatigue. The limits of endurance capacity, which is important for both leisure-sports and fitness, are set primarily by metabolic factors, because the energy liberation via the metabolism of lipids and carbohydrates is reduced as a result of the inhibition of lipolysis and glycogenolysis. Beta 1-selective blockers influence the physical capacity less effectively on any intensity level as non-selective blockers do. The latter may lead to hypoglycemic reactions. Beta-blockers with intrinsic sympathicomimetic activity (ISA) are not superior to others. Physically active patients should be treated with beta 1-selective blockers.
Kindermann
W
W
Institut für Sportmedizin, Universität des Saarlandes, Saarbrücken, BRD.
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D003327:Coronary Disease / Q000188:drug therapy*; D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D010807:Physical Endurance / Q000187:drug effects*; D013177:Sports
D000319:Adrenergic beta-Antagonists
Wie beeinflussen Beta-Rezeptoren-blocker körperliche Leistungs-fähigkeit und Metabolismus?