Effects of busulfan on embryonic cells in vitro.
The DNA synthesis inhibition test and the DNA repair test have been used to study the effects of interaction between busulfan and DNA synthesis in two cell systems in vitro. The results of this study indicate that busulfan at concentration 500 and 1000 micrograms/ml damages mouse and human embryo cells. They also suggest that mouse embryo cells are unable to repair this damage.
Anuszewska
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Institute for Drug Research and Control Chelmska, Warszawa, Poland.
D000818:Animals; D002066:Busulfan / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004260:DNA Repair / Q000187:drug effects; D004622:Embryo, Mammalian / Q000166:cytology* / Q000187:drug effects; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D051379:Mice; D008811:Mice, Inbred DBA; D011247:Pregnancy; D013936:Thymidine / Q000378:metabolism
D008769:Methylnitronitrosoguanidine; D002066:Busulfan; D013936:Thymidine