[Cyclosporin A in the treatment of acquired erythroblastopenia in the course of B-cell chronic lymphatic leukemia].
Acquired erythroblastopenia, or pure red cell aplasia, may appear as a complication of chronic lymphocytic leukaemia. This was the case in a 58 year-old man, diagnosed as having B-cell chronic lymphocytic leukaemia considered as stage C (III). He was treated initially with chlorambucil; two months after diagnosis the patient showed erythroblastopenia, being treated with chlorambucil-prednisone, cyclophosphamide-prednisone, prednisone alone, and intravenous immunoglobulins. No satisfactory response was achieved with any of these drugs. During a period of 28 weeks the patient received 41 units of packed red cells. Cyclosporin-A, at a 9 mg/Kg daily doses, was tested, a dramatic response being observed: after four weeks of such therapy the patient's haemoglobin reached 14.5 g/dL, and he needed no further transfusion since the beginning of this treatment.
Areal Méndez
C
C
Servicio de Hematología y Hemoterapia del Hospital A. Marcide, Ferrol.
Lite Alvarez
J M
JM
Sánchez Varela
J M
JM
D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D002699:Chlorambucil / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use*; D006801:Humans; D007116:Immunization, Passive; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012010:Red-Cell Aplasia, Pure / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy
D002699:Chlorambucil; D016572:Cyclosporine; D003520:Cyclophosphamide; D011241:Prednisone
Ciclosporina-A en el tratamiento de una eritroblastopenia adquirida en el curso de una leucemia linfática crónica de células B.