Discriminant functions in differential diagnosis of hypercalcemic patients.
Using readily available biochemical assays of plasma and urine constituents, we have defined discriminant functions useful as a guide to the differential diagnosis of patients with hypercalcemia. The decreasing rank order of contribution of the variables to the discriminant functions was as follows: plasma albumin, plasma phosphate, plasma chloride, log10 (calcium excretion per liter of glomerular filtrate), and log10 (plasma gamma-glutamyltransferase). Discriminant functions have been defined for patients with values for plasma creatinine above and below 185 mumol/L, and for practical conditions in which plasma and urine samples, or plasma samples only, are available.
Gibb
J A
JA
Department of Biochemical Medicine, Stracathro Hospital, Angus, Scotland, U.K.
Ogston
S A
SA
Paterson
C R
CR
Evans
J R
JR
D002118:Calcium / Q000032:analysis* / Q000097:blood / Q000652:urine; D002712:Chlorides / Q000032:analysis / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D005215:Fasting / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000378:metabolism*; D006961:Hyperparathyroidism / Q000150:complications / Q000378:metabolism*; D010282:Parathyroid Neoplasms / Q000150:complications / Q000378:metabolism*; D010710:Phosphates / Q000032:analysis / Q000097:blood / Q000652:urine; D011237:Predictive Value of Tests; D012709:Serum Albumin / Q000032:analysis*; D005723:gamma-Glutamyltransferase / Q000032:analysis
D002712:Chlorides; D010710:Phosphates; D012709:Serum Albumin; D003404:Creatinine; D005723:gamma-Glutamyltransferase; D002118:Calcium