Translocation (14; 18) and (8; 22) in three patients with acute leukemia/lymphoma following centrocytic/centroblastic non-Hodgkin's lymphoma.
Three patients with centrocytic/centroblastic lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL 2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.
Fiedler
W
W
Department of Oncology and Hematology, University Hospital Eppendorf, Hamburg, Federal Republic of Germany.
Weh
H J
HJ
Zeller
W
W
Fonatsch
C
C
Hillion
J
J
Larsen
C
C
Wörmann
B
B
Hossfeld
D K
DK
D000208:Acute Disease; D000368:Aged; D015139:Blotting, Southern; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D014178:Translocation, Genetic