Changes in plasma catecholamines and pulsatile patterns of gonadotropin release in subjects with a normal ovulatory cycle and with polycystic ovary syndrome.
Plasma LH levels in women and female laboratory animals fluctuate. Since catecholamines play a role in gonadotropin secretion, we investigated the possible correlation between catecholamine metabolites and pulsatile patterns of gonadotropin release by measuring two catecholamine metabolites, MHPG and DOPAC. LH levels had a pulsatile pattern, and the levels of MHPG fluctuated. The average of LH and MHPG in polycystic ovary syndrome was significantly higher than that of a normal ovulatory cycle, and the average fluctuation of LH and MHPG in polycystic ovary syndrome was also significantly greater than that in a normal ovulatory cycle. There may be a correlation between the pulsatile pattern of gonadotropin and catecholamine activity, particularly adrenergic activity. It is suspected that adrenergic activity may correlate with the pulsatile pattern in polycystic ovary syndrome.
Yoshino
K
K
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
Takahashi
K
K
Shirai
T
T
Nishigaki
A
A
Araki
Y
Y
Kitao
M
M
D015102:3,4-Dihydroxyphenylacetic Acid / Q000097:blood*; D000328:Adult; D002395:Catecholamines / Q000097:blood; D002853:Chromatography, Liquid; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006018:Glycols; D006062:Gonadotropins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives* / Q000097:blood; D010060:Ovulation / Q000502:physiology*; D010648:Phenylacetates / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis
D002395:Catecholamines; D006018:Glycols; D006062:Gonadotropins; D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid; C037157:3-methoxy-4-hydroxyphenylglycol glucuronide; D008734:Methoxyhydroxyphenylglycol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone