title: Hypothesis: Helicobacter pylori, urease, mucus, and gastric ulcer.
abstract: Ammonia, released in the gastric mucosa by the action of Helicobacter pylori urease on transuded plasma urea, curtails the biosynthesis of mucus and/or causes the mucus to be disassembled at the mucosal surface. These changes facilitate colonisation by H pylori and may promote gastric ulcer formation.
authors.affiliation: Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: R L
authors.initials: RL
authors.lastname: Sidebotham
authors.forename: J H
authors.initials: JH
authors.lastname: Baron
mesh_terms: D002167:Campylobacter / Q000201:enzymology*; D002169:Campylobacter Infections / Q000150:complications*; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D013276:Stomach Ulcer / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D014510:Urease / Q000378:metabolism*
chemical_list: D014510:Urease