A vascular effect of IgG therapy may prevent transplacental red cell leakage and spontaneous thrombocytopenic haemorrhages.
It is postulated that intravenous immunoglobin therapy may improve the red cell barrier of placenta and of capillary endothelia; the former protecting against anti-Rh antibody booster reaction and the latter preventing spontaneous thrombocytopenic bleedings. The effect on permeability may also reduce the passage of anti-Rh antibodies to the foetus.
Rewald
E
E
Fundaciòn Hematològica, Mar del Plata, Argentina.
D002199:Capillary Permeability; D004912:Erythrocytes; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage*; D007136:Immunoglobulins / Q000008:administration & dosage; D008875:Middle Aged; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D018029:Rho(D) Immune Globulin; D013921:Thrombocytopenia / Q000628:therapy
D007074:Immunoglobulin G; D007136:Immunoglobulins; D018029:Rho(D) Immune Globulin