Association of renal carcinoma and polycythemia vera: 5 cases in which nephrectomy preceded and did not influence the clinical course of the polycythemia.
In a series of 300 cases of PV evaluated and treated over the last 12 years, 5 cases had a kidney carcinoma, either previously treated (2 cases) or discovered at the same time as the PV (3 cases). In all these cases, the blood disease had the criteria of a myeloproliferative syndrome (abnormality of three cell-lines), was not influenced by nephrectomy and evolved in the long term like a primary PV. No kidney cancer was observed during follow-up of the other 32P treated PV patients. There appears to be an abnormal association between PV and kidney cancer which needs confirmation in larger series and would justify a prospective evaluation.
Najean
Y
Y
Département de Médecine Nucléaire, Hôpital Saint-Louis, Paris, France.
D000230:Adenocarcinoma / Q000150:complications / Q000453:epidemiology / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications / Q000453:epidemiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011087:Polycythemia Vera / Q000150:complications*; D012189:Retrospective Studies; D013997:Time Factors