[A pharmacological analysis of the central monoaminergic mechanisms of the development of neurogenic stomach damage].
It was found that 3 hours after electrostimulation of the immobilized rats there was observed in addition to destructive lesions in the gastric mucosa a significant decrease of noradrenaline, dopamine, DOPA, homovanillic acid and creatine phosphate levels in the brain tissue involving the hypothalamus and the midbrain surrounding it. The use before the extreme impact of neurotropic agents blocking transmission of the damaging impulses from the site of stimulation of reflexogenic zones through the central adrenergic synapses which activate genome in the nerve cell or prevent depletion of catecholamine stores and disturbance of energy formation processes in the brain tissue protects against the development of neurogenic damage of the stomach.
Bul'on
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VV
Khnychenko
L K
LK
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000662:Amphetamines / Q000627:therapeutic use; D000818:Animals; D044482:Benzeneacetamides; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006220:Haloperidol / Q000627:therapeutic use; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D010627:Phenethylamines / Q000627:therapeutic use; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D012149:Restraint, Physical; D013270:Stomach / Q000187:drug effects / Q000294:innervation*; D013272:Stomach Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control
D000319:Adrenergic beta-Antagonists; D000662:Amphetamines; D044482:Benzeneacetamides; D015306:Biogenic Monoamines; D010627:Phenethylamines; D011956:Receptors, Cell Surface; C009756:fepracet; D007980:Levodopa; C022075:IEM 611; D006220:Haloperidol
Farmakologicheskiĭ analiz tsentral'nykh monoaminergicheskikh mekhanizmov razvitiia neĭrogennogo povrezhdeniia zheludka.