[Clinico-histopathologic correlation of ganciclovir-treated cytomegalovirus retinitis].
A 46 year old AIDS-patient, who had developed CMV-retinitis was treated with the virostatic drug dihydroxypropoxymethylguanine (DHPG, Ganciclovir) over a period of 16 months until he died due to a pneumonia. After the DHPG-treatment was initiated the retinitis improved markedly, however there still was a very slow progression of the disease in the following time. The central retina of both eyes was not affected until death. Postmortal immunohistochemically CMV-antigen-staining was positive according to the former clinically active retinitis. At the eyes of the retinal necrosis calcified deposits were identified by Kossa-staining; these areas had clinically appeared as yellowish briddle deposits. The clinical course and the immunohistochemical proof of active CMV-virus-particles suggest that DHPG was able to suppress the progression of a CMV-retinitis and to preserve a good visual acuity until death; however a true cure of the CMV-infection could not be achieved.
Daus
W
W
Universitätsaugenklinik Heidelberg.
Kaps
D
D
Völcker
H E
HE
D000914:Antibodies, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000187:drug effects* / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000473:pathology*; D005451:Fluorescein Angiography; D015774:Ganciclovir / Q000627:therapeutic use*; D015658:HIV Infections / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000188:drug therapy / Q000473:pathology*; D012160:Retina / Q000473:pathology; D012173:Retinitis / Q000188:drug therapy / Q000473:pathology*; D014792:Visual Acuity / Q000187:drug effects; D014794:Visual Fields / Q000187:drug effects
D000914:Antibodies, Viral; D015774:Ganciclovir
Klinisch-histopathologische Korrelation der mit Ganciclovir behandelten Cytomegalievirus-Retinitis.