[Intermembrane exchange of lipids induced by cobra venom cytotoxins].
Interaction between cytotoxin Vc5 from cobra venom and model membranes from phosphatidylcholine and phosphatidyl acid was investigated by means of 1H-NMR, ESR spin probes and microcalorimetric methods. Cytotoxic was shown to induce in the membrane formation of non-bilayer structures, to increase the membrane permeability and to produce the intermembrane exchange with lipids.
Gasanov
S E
SE
Aripov
T F
TF
Salakhutdinov
B A
BA
D002462:Cell Membrane / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D003603:Cytotoxins / Q000633:toxicity*; D004546:Elapid Venoms / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D009682:Magnetic Resonance Spectroscopy; D008563:Membrane Lipids / Q000378:metabolism*
D003603:Cytotoxins; D004546:Elapid Venoms; D008563:Membrane Lipids
Mezhmembrannyĭ obmen lipidami, indutsiruemyĭ tsitoksinami iada kobry.