Effect of dibutyrylo cyclic AMP on glycocalyx formation in the intestinal epithelial cells of salivectomised mice.
Effect of dibutyryl cyclic AMP on glycocalyx formation in intestinal epithelial cells of salivectomised mice was studied. After salivectomy, a marked reduction of glycocalyx layer on the surface of microvilli was noted. Twenty four hours after the first injection of dibutyrylo cyclic AMP, restoration of the thick layer of glycocalyx was confirmed. The results obtained suggest that dibutyrylo cyclic AMP regulates the synthesis of glycocalyx in Golgi complex.
Dyduch
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Silesian Pediatric Center, Silesian School of Medicine, Zabrze.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D004285:Dogs; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D006023:Glycoproteins / Q000096:biosynthesis*; D006056:Golgi Apparatus / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D011134:Polysaccharides / Q000096:biosynthesis*; D013363:Submandibular Gland / Q000502:physiology / Q000601:surgery
D006023:Glycoproteins; D011134:Polysaccharides; D003994:Bucladesine