title: Anaplastic large cell lymphoma, CD30/Ki-1 positive, expressing the CD15/Leu-M1 antigen. Immunohistochemical and morphological relationships to Hodgkin's disease.
abstract: In this report we analyze the morphological and immunohistochemical findings observed in 5 cases of CD30/Ki-1 positive anaplastic large cell lymphoma, a recently recognized neoplastic entity. In comparison with the Ki-1 lymphomas so far described, these cases showed a fairly large number of Reed-Sternberg-like cells, often admixed with small lymphocytes and occasional eosinophils. Moreover, in all our cases immunohistochemical reactions detected the CD15/Leu-M1 antigen, together with markers of the T-lineage and of lymphoid activation. In previous studies the CD15/Leu-M1 antigen has been found in the majority of cases of Hodgkin's disease, but has been stated to be absent typically in Ki-1 lymphomas. Our results indicate that this antigen cannot be considered a reliable tool to distinguish between Ki-1 lymphomas and Hodgkin's disease. Furthermore, the morphological and immunohistochemical findings reported suggest that in some cases Ki-1 cell lymphoma and Hodgkin's disease may be closely related. They may represent different steps in the progression of the same lymphoproliferative disorder.
authors.affiliation: Department of Human Pathology, University of Pavia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Rosso
authors.forename: M
authors.initials: M
authors.lastname: Paulli
authors.forename: U
authors.initials: U
authors.lastname: Magrini
authors.forename: S
authors.initials: S
authors.lastname: Kindl
authors.forename: E
authors.initials: E
authors.lastname: Boveri
authors.forename: G
authors.initials: G
authors.lastname: Volpato
authors.forename: S
authors.initials: S
authors.lastname: Poggi
authors.forename: P
authors.initials: P
authors.lastname: Baglioni
authors.forename: S
authors.initials: S
authors.lastname: Pileri
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000276:immunology; D000943:Antigens, Differentiation / Q000276:immunology*; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016256:Lewis X Antigen; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D016256:Lewis X Antigen