Ovarian steroids increase veratridine-induced release of amino acid neurotransmitters in preoptic area synaptosomes.
In vivo treatment of ovariectomized rats with estradiol benzoate plus progesterone, but not with either steroid alone, produced a large increase in veratridine-induced release of radiolabeled glutamate and newly synthesized GABA from preoptic area synaptosomes in vitro. Neither basal nor KCl-evoked release of amino acids was altered. Thus gonadal steroids appear to be involved in the control of amino acid neurotransmitter release in a brain region of importance for regulation of female reproductive physiology and behavior.
Fleischmann
A
A
Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10461.
Makman
M H
MH
Etgen
A M
AM
D000818:Animals; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005971:Glutamates / Q000493:pharmacokinetics*; D018698:Glutamic Acid; D010052:Ovariectomy; D011301:Preoptic Area / Q000187:drug effects / Q000378:metabolism*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D014701:Veratridine / Q000494:pharmacology*; D014702:Veratrine / Q000031:analogs & derivatives*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D018698:Glutamic Acid; D011374:Progesterone; D004958:Estradiol; D005680:gamma-Aminobutyric Acid; D014701:Veratridine; D014702:Veratrine