[The reorganization of the temporal dynamics of stereotyped behavior in rats induced by the acute and chronic administration of fenamine in disordered functioning of the beta-adrenergic mechanisms].
Amphetamine-induced stereotyped behaviour of rats is a nonsteady oscillatory process. After combination of acute amphetamine and beta-adrenoblocker propranolol a lowering of amplitude and limitation of rhythmicity of stereotype were observed. But chronic propranolol intensified the stereotypy without usual increase of the number of short-period (2-3/min) fluctuations in the time course of the process. It is suggested that potentiation of behavioural disturbances by propranolol may be the result of blockade of pineal beta-adrenergic receptors and weakening of brain adaptive mechanisms function.
Popov
A V
AV
Arushanian
E B
EB
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D004357:Drug Synergism; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D000661:Amphetamine
Perestroĭka vremennóĭ dinamiki stereotipnogo povedeniia krys, vyzyvaemogo ostrym i khronicheskim vvedeniem fenamina, pri narushenii funktsii beta-adrenergicheskikh mekhanizmov.