Intracerebroventricular myo-inositol antagonizes lithium-induced suppression of rearing behaviour in rats.
Several biological effects of lithium have been reversed by in vitro myo-inositol. To determine if intracerebroventricular myo-inositol would reverse behavioural effects of lithium, rats were injected with 5 meq/kg lithium chloride or sodium chloride and injected intracranially with myo-inositol (10 mg) or artificial CSF 24 h and 15 min prior to measurement of activity in an automated activity monitor. Myo-inositol alone had no significant effect on behaviour, but significantly reversed suppression of rearing activity by lithium.
Kofman
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O
Beer-Sheva Mental Health Center, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Belmaker
R H
RH
D000704:Analysis of Variance; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D002712:Chlorides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007276:Injections, Intraventricular; D007294:Inositol / Q000008:administration & dosage / Q000494:pharmacology*; D008094:Lithium / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D018021:Lithium Chloride; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012016:Reference Values
D002712:Chlorides; D007294:Inositol; D008094:Lithium; D018021:Lithium Chloride