title: Activation of the anticancer drug CCNU into a free radical intermediate via UV irradiation--an ESR study.
abstract: We studied the formation of a free radical induced by UV irradiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in benzene. It was determined a stable nitroxide radical by ESR spectroscopy. We confirmed that sterically hindered cyclic amine 2,2,6,6-tetramethyl-4-piperidone (TMPone) was transformed into a corresponding stable free nitroxyl radical during UV irradiation. When CCNU was present, the rate of free radical formation from TMPone increased considerably.
authors.affiliation: Department of Chemistry and Biochemistry, Laboratory of Molecular Oncology, Stara Zagora, Bulgaria.
authors.forename: Z D
authors.initials: ZD
authors.lastname: Raikov
authors.forename: A M
authors.initials: AM
authors.lastname: Zheleva
authors.forename: E T
authors.initials: ET
authors.lastname: Raikova
mesh_terms: D001554:Benzene; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D008130:Lomustine / Q000737:chemistry / Q000528:radiation effects*; D014216:Triacetoneamine-N-Oxyl; D014466:Ultraviolet Rays
chemical_list: D005609:Free Radicals; D014216:Triacetoneamine-N-Oxyl; D008130:Lomustine; D001554:Benzene