[Effects of diazepam and N(6)-cyclohexyladenosine on the level of diazepam-binding inhibitor in structures of the hippocampus during immobilization stress].
The Diazepam-binding inhibitor (DBI) levels were studied under stress-reaction condition and after diazepam and N6-cyclohexyladenosine injections. The radioimmune method was used to study the DBI levels. It was shown, that DBI level increased during stress-reaction. Diazepam and N6-cyclohexyladenosine injection decreased DBI level in these conditions. On the basis of these data the authors proposed the hypothetic model of interaction between adenosine receptors and GABA-Benzodiazepine-receptor complex.
Poltavchenko
G M
GM
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D003975:Diazepam / Q000378:metabolism / Q000494:pharmacology*; D026261:Diazepam Binding Inhibitor; D006624:Hippocampus / Q000737:chemistry*; D007103:Immobilization; D008297:Male; D008954:Models, Biological; D009479:Neuropeptides / Q000032:analysis*; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism; D011983:Receptors, Purinergic / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*
D026261:Diazepam Binding Inhibitor; D009479:Neuropeptides; D011963:Receptors, GABA-A; D011983:Receptors, Purinergic; C027513:N(6)-cyclohexyladenosine; D000241:Adenosine; D003975:Diazepam
Vliianie diazepama i 6N-tsiklogeksiladenozina na uroven' diazepamsviazyvaiushchego ingibitora v strukturakh gippokampa na fone immobilizatsionnogo stressa.