title: The pharmacokinetics of oxycodone after intravenous injection in adults.
abstract: Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative day. Plasma was sampled for up to 12 h. Mean values of t1/2z, CL and Vss were 222 min, 0.78 l min-1 and 2.60 l kg-1, respectively. The concentrations of the metabolite noroxycodone was also measured. The mean AUC(0,12) ratio of noroxycodone to oxycodone was 0.33. Oxymorphone was not detected.
authors.affiliation: Department of Anaesthesia, University of Helsinki, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Pöyhiä
authors.forename: K T
authors.initials: KT
authors.lastname: Olkkola
authors.forename: T
authors.initials: T
authors.lastname: Seppälä
authors.forename: E
authors.initials: E
authors.lastname: Kalso
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010098:Oxycodone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010111:Oxymorphone / Q000493:pharmacokinetics
chemical_list: D010111:Oxymorphone; D010098:Oxycodone