[Synthesis, structure and properties of rubomycin derivatives of mono- and oligonucleotides].
Daunomycin derivatives of pT(DT) and oligodeoxynucleotides were synthesized using reactive zwitter-ionic 4-N,N-dimethylaminopyridine derivatives of the terminal phosphate group. Daunomycin oligodeoxynucleotide analogues form more stable complementary complexes than the corresponding non-modified oligonucleotides. Both one- and two-dimensional (2D NOESY and 2D COSY) NMR spectra of DT were recorded and the proton signals assigned. From the detected cross-relaxation between H6 of thymidine and H1', H2', H2" of the carbohydrate residue of daunomycin it was concluded that, in DMSO, the DT molecule has a rather stable conformation, apparently due to the stacking interaction between the mononucleotide and daunomycin residues.
Godovikova
T S
TS
Zarytova
V F
VF
Lokhov
S G
SG
Mal'tseva
T V
TV
Sergeev
D S
DS
D003630:Daunorubicin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
D003630:Daunorubicin
Sintez, struktura i svoĭstva rubomitsinovykh proizvodnykh mono- i oligonukleotidov.