Correlation between the macromolecular effects of estradiol and catecholestradiols and the total prostatic catecholestrogen concentration.
Various authors have demonstrated that estrogens stimulate both protein and DNA synthesis, as well as cell proliferation. This study was therefore undertaken to investigate the correlation between these physiological effects of estrogens and the total prostatic catecholestrogens. Either 17 beta-estradiol (5 ng), 2-hydroxyestradiol (40 ng), 4-hydroxyestradiol (17 ng), propane-1,2-diol or a saline solution was injected intraperitoneally to 22-day-old Sprague-Dawley rats daily. Regardless of the treatment, the prostate mass, the rate of DNA or protein synthesis correlates positively with the total prostatic catecholestrogen concentration. We therefore conclude that the effect of each estrogen per se should be regarded in terms of the total prostatic catecholestrogen concentration.
Nieuwoudt
L B
LB
Wolmarans Research Laboratory, Department of Urology, University of Pretoria, Republic of South Africa.
van Aswegen
C H
CH
Böckmann
H I
HI
van der Merwe
C A
CA
du Plessis
D J
DJ
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology*; D002393:Estrogens, Catechol / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000494:pharmacology; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D002393:Estrogens, Catechol; D011409:Propylene Glycols; D004958:Estradiol; D019946:Propylene Glycol; D004247:DNA; C001390:2-hydroxyestradiol; C014036:4-hydroxyestradiol