Ototoxicity of an ototopic preparation--experimental results and clinical facts.
The ototoxicity of "Cortisporin Otic Suspension" containing 3.5 ml neomycin base, 10,000 units/ml polymyxin B was studied using the baboon (papio ursinus) as an experimental animal. Inner and outer hair cell loss occurred in all cochleas of the ears which received cortisporin. Most lesions were confined to the basal turn of the organ of Corti. Separate evaluation of polymyxin B and neomycin at the same concentration as in cortisporin showed that polymyxin B produced greater cochlear damage. The results of this study and clinical reports of sensorineural hearing loss due to commercially available ear drops indicate that ototopical preparations must be used with caution in clinical situations in which they may reach the middle ear.
Halama
A R
AR
Department of Otorhinolaryngology, Head/Neck Surgery, Akademisch Ziekenhuis, Vrije Universiteit Brussel, Belgium.
Wright
C G
CG
Meyerhoff
W L
WL
D000818:Animals; D004338:Drug Combinations; D006198:Hair Cells, Auditory / Q000187:drug effects*; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced; D006801:Humans; D006854:Hydrocortisone / Q000633:toxicity*; D009355:Neomycin / Q000633:toxicity*; D009925:Organ of Corti / Q000187:drug effects*; D010215:Papio; D011112:Polymyxin B / Q000633:toxicity*; D013535:Suspensions
D004338:Drug Combinations; D013535:Suspensions; C033225:hydrocortisone, neomycin, polymyxin B drug combination; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone