title: Flow cytometric DNA histograms of paraffin-embedded pheochromocytomas.
abstract: We proposed a new classification of pheochromocytomas according to DNA ploidy patterns. Proliferation index (PI = S% + 4C%) might be an alternative to 4C% which was used as a critical marker of DNA nonaneuploid histograms. The follow-up survey revealed that DNA tetraploid with minimum increase of PI could not rule out the substantial possibility of malignancy and the comparison of DNA diploid histograms disclosed that 22 and 0% showed significant increase of the ratio of 4C% to S% under PI and 4C% criteria, respectively. In conclusion, 4C% was more effective and reliable than PI in order to classify DNA nonaneuploid pheochromocytomas.
authors.affiliation: Department of Urology, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hosaka
authors.forename: Y
authors.initials: Y
authors.lastname: Aso
authors.forename: L M
authors.initials: LM
authors.lastname: Rainwater
authors.forename: C S
authors.initials: CS
authors.lastname: Grant
authors.forename: G M
authors.initials: GM
authors.lastname: Farrow
authors.forename: J A
authors.initials: JA
authors.lastname: van Heerden
authors.forename: M M
authors.initials: MM
authors.lastname: Lieber
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000145:classification / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D016612:Paraffin Embedding; D010673:Pheochromocytoma / Q000145:classification / Q000235:genetics*; D011003:Ploidies
chemical_list: D004273:DNA, Neoplasm