title: Age-related differences in concomitant hormone release from the superfused rat adenopituitary.
abstract: We screened the concomitant release of five adenopituitary (AP) hormones, in vitro, at basal and stimulated conditions, in young and aged (2-3 and 25 months old, respectively) male Fischer 344 rats. The APs of aged rats exhibited significantly higher basal and total release of prolactin, but lower release of luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone and growth hormone than those of young rats. The APs of aged rats did not respond to high K+ depolarization by an increased release of any of the studied hormones, whereas the APs of young rats did release a significant amount in all instances. The results indicate marked age-related alterations affecting the release of the hormones, detectable even in the isolated AP alone.
authors.affiliation: Department of Anesthesiology, UMD-New Jersey Medical School, Newark.
authors.forename: V
authors.initials: V
authors.lastname: Zbuzek
authors.forename: B B
authors.initials: BB
authors.lastname: Arnetz
authors.forename: P
authors.initials: P
authors.lastname: Eneroth
authors.forename: V K
authors.initials: VK
authors.lastname: Zbuzek
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D010908:Pituitary Hormones, Anterior / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D010908:Pituitary Hormones, Anterior; D011188:Potassium