title: Role of central angiotensinergic mechanism in shaking stress-induced ACTH and catecholamine secretion.
abstract: The role of central angiotensin II (AII) in the shaking stress-induced adrenocorticotropic hormone (ACTH), plasma catecholamine secretion and pressor response were investigated using conscious rats. We also studied whether or not vasopressin (VP) is involved in the shaking stress-induced pressor response. The shaking stress caused significant elevations in plasma ACTH, catecholamine, and systolic blood pressure. Intra-third ventricular administration of the AII antagonist, Sar1, Ile8-angiotensin II (saralasin) significantly attenuated pressor response and plasma noradrenaline elevation but not plasma ACTH elevation. Pretreatment with the vascular-type VP receptor (V1) antagonist, d(CH2)5Tyr(Me)AVP, did not attenuate pressor response nor plasma catecholamine elevation. These results indicate that the central angiotensinergic pathway at least partly mediates the shaking stress-induced activation of the sympathetic nervous system without VP involvement, and that central AII does not mediate the ACTH secretion evoked by shaking stress.
authors.affiliation: Third Department of Internal Medicine, Okayama University Medical School, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Hirasawa
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Z
authors.initials: Z
authors.lastname: Ota
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D002395:Catecholamines / Q000502:physiology*; D002404:Catheterization; D007276:Injections, Intraventricular; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012504:Saralasin / Q000494:pharmacology; D013312:Stress, Physiological / Q000503:physiopathology*; D014667:Vasopressins / Q000378:metabolism
chemical_list: D002395:Catecholamines; D014667:Vasopressins; D000804:Angiotensin II; D001127:Arginine Vasopressin; C025043:vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-; D000324:Adrenocorticotropic Hormone; D012504:Saralasin