[Partial removal of the mesenchyma disrupts the growth and differentiation of the epithelium in respiratory tract explants from strain A and C57BL mouse embryos].
Differentiation of respiratory epithelium (E) of 17-day old embryos of A and C57BL mice after partial removal of mesenchyme (M) was studied in organ culture. In control explants, tissue-specific growth and differentiation of epithelium were observed during long-term culturing. Ih both mouse strains, partial removal of mesenchyme prevented the development of alveolar-like structures in explants of distal part of respiratory tract. In most explants of proximal part of respiratory tract (65.1% in A mice and 85.7% in C57BL mice) with partially removed mesenchyme, we found atypical epithelial structures and foci of poorly differentiated cells with high proliferation rate.
Kolesnichenko
T S
TS
Medvinskiĭ
A L
AL
D000818:Animals; D001980:Bronchi / Q000196:embryology*; D002454:Cell Differentiation; D004847:Epithelial Cells; D005865:Gestational Age; D008648:Mesoderm / Q000502:physiology*; D051379:Mice; D008805:Mice, Inbred A / Q000196:embryology*; D008810:Mice, Inbred C57BL / Q000196:embryology*; D009924:Organ Culture Techniques
Chastichnoe udalenie mezenkhimy narushaet rost i differentsirovku épiteliia v éksplantatakh respiratornogo trakta zarodysheĭ mysheĭ liniĭ A i C57BL.