Comparative bioavailability of rectal and oral formulations of chloroquine.
The relative bioavailability of chloroquinone in Witepsol H15 suppositories can vary between 10 and 53% of the bioavailability of a tablet formulation in adults. Therefore, it is therapeutically not sound to replace chloroquine tablets by a rectal formulation with the same dose.
Tjoeng
M M
MM
Clinical Pharmacy Department, St. Elisabeth Hospital, Amersfoort, The Netherlands.
Hogeman
P H
PH
Kapelle
H
H
De Ridder
M L
ML
Verhaar
H
H
D000284:Administration, Oral; D000285:Administration, Rectal; D000328:Adult; D001682:Biological Availability; D002738:Chloroquine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D002738:Chloroquine