Effects of 1,25(OH)2D3 on cardiovascular function.
1,25(OH)2D3 enhances myocardial contractility with pharmacological doses from 1 to 20 micrograms within 30-60 min. dp/dt modifications induced by 1,25(OH)2D3 are dose dependent and approach linearity from 1 to 10 micrograms. The inotropic effects are not dependent on extracellular Ca2+ levels; but cellular Ca2+ influx or internal Ca2+ movement may be implied. The effect seems not related to the described 1,25(OH)2D3 receptors which implies protein de novo synthesis. A modulation on other receptor-mediated substances acting on Ca2+ movements seems probable.
Jahn
H
H
Nephrology Department, Louis-Pasteur University, Strasbourg, France.
Schohn
D
D
Omichi
A
A
Miller
R
R
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D016277:Ventricular Function, Left / Q000187:drug effects
D000804:Angiotensin II; D002117:Calcitriol; D007545:Isoproterenol; D002118:Calcium; D009638:Norepinephrine