title: Increased efficacy of ganciclovir and foscarnet inhibition of cytomegalovirus replication in vitro by encapsulation in liposomes.
abstract: The antiviral effect of ganciclovir and foscarnet encapsulated in liposomes was studied against cytomegalovirus in human embryonic lung fibroblast cells. Substantially greater activity (3.5-fold and 38-fold respectively) in terms of inhibition of virus replication intracellularly was found compared to that seen with non-encapsulated antiviral agents, and liposome encapsulation did not result in increased cytotoxicity.
authors.affiliation: Department of Clinical Microbiology, Erasmus University Rotterdam, The Netherlands.
authors.forename: I A
authors.initials: IA
authors.lastname: Bakker-Woudenberg
authors.forename: A F
authors.initials: AF
authors.lastname: Lokerse
authors.forename: M
authors.initials: M
authors.lastname: ten Kate
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects* / Q000502:physiology; D004337:Drug Carriers; D005347:Fibroblasts / Q000187:drug effects / Q000382:microbiology; D017245:Foscarnet; D015774:Ganciclovir / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D008081:Liposomes; D010746:Phosphonoacetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D004337:Drug Carriers; D008081:Liposomes; D017245:Foscarnet; D010746:Phosphonoacetic Acid; D015774:Ganciclovir