title: Relationships between obesity and ischaemic heart disease in type II diabetic subjects homozygous for the apoprotein E3 allele.
abstract: The purpose of the present study was to evaluate the influence of obesity on ischaemic heart disease frequency in a well-documented type II diabetic population. To eliminate one of the possible sources of variability for plasma lipid concentrations, only subjects showing the apoprotein E phenotype, indicative of homozygosity for the epsilon 3 allele (i.e. an E3/E3 genotype), have been recruited. A larger prevalence of ischaemic heart disease was noticed among obese patients as compared to non-obese or merely overweight subjects according to a higher frequency of hypertension and to higher triglyceride concentrations. These results corroborate the hypothesis of a common pathogenesis of the major cardiovascular risk factors.
authors.affiliation: Division of Diabetology and Metabolic Diseases, I.N.R.C.A., Ancona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Boemi
authors.forename: F
authors.initials: F
authors.lastname: Romagnoli
authors.forename: G
authors.initials: G
authors.lastname: De Tommaso
authors.forename: R
authors.initials: R
authors.lastname: Ricciotti
authors.forename: P
authors.initials: P
authors.lastname: Fumelli
mesh_terms: D000483:Alleles; D053318:Apolipoprotein E3; D001057:Apolipoproteins E / Q000235:genetics*; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D009765:Obesity
chemical_list: D053318:Apolipoprotein E3; D001057:Apolipoproteins E