Human extravillous trophoblast MHC class I expression is resistant to regulation by interferon-alpha.
We have shown that MHC Class I antigen expression by first trimester human extravillous trophoblast cells is resistant to upregulation by IFN-alpha while embryonic fibroblasts of the same gestational age are responsive. This is in contrast to our previous finding that IFN-gamma increases both Class I mRNA and surface expression in these trophoblast cells. It would appear that human trophoblast has differential susceptibility to the effects of the two classes of IFN.
Chumbley
G
G
Department of Pathology, University of Cambridge, U.K.
Hawley
S
S
Carter
N P
NP
Loke
Y W
YW
D005260:Female; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I / Q000187:drug effects / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D008285:Major Histocompatibility Complex / Q000235:genetics; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012333:RNA, Messenger / Q000032:analysis* / Q000187:drug effects; D014327:Trophoblasts / Q000187:drug effects / Q000276:immunology*
D006680:HLA Antigens; D016898:Interferon-alpha; D012333:RNA, Messenger