[Intrinsic (isobaric) effect of essential hypertension on visco-elastic properties of the brachial artery].
The purpose of this study was to estimate the effect of hypertension on the visco-elastic properties of the brachial artery in man. Seventy-five subjects including 23 with normal blood pressure (group N, PN = 95 +/- 7 mmHg, P designates the arterial mean pressure, P = DBP + (SBP-DBP)/3) and 52 with essential hypertension (group H, PH = 122 +/- 12 mmHg) participated to this study. We measured the diameter of the brachial artery (D) by the pulsed Doppler method, the brachial-radial pulse wave velocity (PWV) by the mecanographic method, and calculated the arterial compliance (C) by the Bramwell-Hill formula. A nonlinear model was used to calculate compliance and pression at any given pressure, in particular at PN or PH. We obtained the following results: [table; see text] Passive (pressure-induced) effect was obtained by comparing D(PH) to D(PN) and C(PH) to C(PN). Isobaric effect of hypertension was estimated by comparing D(PH) and C(PN) between the N and H groups. We concluded that hypertension actually induces a decrease in compliance. However, arterial diameter is increased in hypertension. The increase in diameter appears as a compensatory effect, without which the reduction in compliance would be more nocive to the circulatory system.
Chau
N P
NP
URBB, INSERM U263, université Paris.
Simon
A
A
Flaud
P
P
Vilar
J
J
Levenson
J
J
D000328:Adult; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004548:Elasticity; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography
Effet intrinsèque (isobarique) de l'hypertension artérielle essentielle sur les propriétés visco-élastiques de la paroi de l'artère humérale.