title: Persistent superior oblique paresis as a manifestation of familial periodic cerebellar ataxia.
abstract: A brother and sister complained of persistent diplopia due to superior oblique palsies. The cause of their symptoms became apparent when they were diagnosed as having familial periodic cerebellar ataxia (FPCA), a rare autosomal dominant condition. Oral acetazolamide (250 mg twice daily) not only prevented all the periodic symptoms but also relieved their diplopia, which had been present between attacks.
authors.affiliation: Department of Neurology, UMDS, Guy's Hospital, London.
authors.forename: P G
authors.initials: PG
authors.lastname: Bain
authors.forename: G B
authors.initials: GB
authors.lastname: Larkin
authors.forename: D M
authors.initials: DM
authors.lastname: Calver
authors.forename: M D
authors.initials: MD
authors.lastname: O'Brien
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use; D000293:Adolescent; D002524:Cerebellar Ataxia / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D004172:Diplopia / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D010243:Paralysis / Q000209:etiology*
chemical_list: D000086:Acetazolamide