[Removal of the endothelium eliminates the stress-induced adrenoreactivity of the aorta].
Emotional painful stress, experimental myocardial infarction and surgical stress induced by thoracotomy decreased the adrenoreactivity of isolated rat aorta with intact endothelium. The endothelium removal enhanced the response of aorta to noradrenaline, the enhancement being much more pronounced after stress exposures than in control. As a result, the adrenoreactivity of denuded preparations from stress-exposed animals appeared to be not reduced but, on the contrary, increased in comparison with the control. Since stress is known to increase the density and the affinity of alpha 2-adrenoceptors to a much more extent than those of alpha 1-adrenoceptors, it was suggested that the revealed in this work stress-induced potentiation of the inhibitory effect of the endothelium is due to the hyperactivation of endothelial alpha 2-adrenoceptors which mediate the release of endothelium derived relaxing factor. The significance of the effect in the development of pathological states of the organism is discussed.
Manukhina
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EB
D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000294:innervation; D004730:Endothelium, Vascular / Q000503:physiopathology*; D004837:Epinephrine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology*; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000032:analysis / Q000502:physiology; D013315:Stress, Psychological / Q000503:physiopathology*
D011942:Receptors, Adrenergic, alpha; D009569:Nitric Oxide; D004837:Epinephrine
Udalenie éndoteliia ustraniaet stressornoe snizhenie adrenoreaktivnosti aorty.