Immunogenicity of mannophosphoinositides of mycobacteria: effect of cord factor (trehalose-6,6'-dimycolate).
Attempts were made to enhance the immunogenicity of mannophosphoinositides of mycobacteria against experimental tuberculosis. It was found that immunization of mice with a combination of mannosides and cord factor, coupled to methylated bovine serum albumin (MBSA) could not further alter the protective efficacy of mannoside-MBSA complexes against challenge with a LD50 dose of M. tuberculosis H37Rv as seen by survival-to-mortality rate, root-specific lung mass, lung density and bacterial counts recovered from the infected organs.
Mehta
P K
PK
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Khuller
G K
GK
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D003311:Cord Factors / Q000276:immunology*; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D007106:Immune Sera / Q000276:immunology; D007114:Immunization; D051379:Mice; D008815:Mice, Inbred Strains; D009161:Mycobacterium / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D010716:Phosphatidylinositols / Q000276:immunology*; D014376:Tuberculosis / Q000517:prevention & control*
D000907:Antibodies, Bacterial; D003311:Cord Factors; D007106:Immune Sera; D010716:Phosphatidylinositols; C002423:mannophosphoinositide