Constituents of leguminous plants, XIII. New triterpenoid saponins from Wistaria brachybotrys.
Two new triterpenoid saponins, wistariasaponins D [1] amd G [2], and the known saponin dehydrosoyasaponin I [3] were isolated from the knots of Wistaria brachybotrys. The Structures of 1 and 2 were determined from their chemical and physicochemical evidence. The inhibitory effects of these saponins on the activation of Epstein-Barr virus early antigen that was induced by a tumor promoter were also tested for the primary screening of antitumor-promoting activities.
Konoshima
T
T
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku 607, Japan.
Kozuka
M
M
D000956:Antigens, Viral / Q000096:biosynthesis; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D002240:Carbohydrate Sequence; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010944:Plants; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000956:Antigens, Viral; D000972:Antineoplastic Agents, Phytogenic; C033305:Epstein-Barr virus early antigen; D012503:Saponins; D014315:Triterpenes; C071764:dehydrosoyasaponin I; C071766:wistariasaponin G; C071765:wistariasaponin D; D009828:Oleanolic Acid; D013755:Tetradecanoylphorbol Acetate