title: [The effect of isosorbide dinitrate spray on patients receiving coronary artery bypass grafting].
abstract: The effect of isosorbide dinitrate (ISDN) spray on hemodynamics and coronary artery diameter was studied in 10 patients with ischemic heart disease. Significant decrease in systolic blood pressure and systolic and diastolic pulmonary artery pressure was recognized at 2 minutes after spray. But there were no significant changes in heart rate and diastolic blood pressure. The diameter of the right coronary artery was 2.6 +/- 0.3 mm before ISDN, which significantly increased to 3.5 +/- 0.4 mm after ISDN. Then, the effect of ISDN on saphenous vein (SV) graft and internal thoracic artery (ITA) graft in 5 patients receiving coronary artery bypass grafting was assessed. The diameter of ITA was 1.7 +/- 0.2 mm before ISDN, and that was 2.0 +/- 0.2 mm after ISDN. The increase was recognized in all patients. The diameter of SV was 4.0 +/- 0.3 mm before ISDN, and that was 4.0 +/- 0.3 mm after ISDN. The diameter of the left anterior descending artery was 1.9 +/- 0.2 mm before ISDN, and that was 2.4 +/- 0.4 mm after ISDN. It was concluded that ISDN spray had a vasodilation effect on ITA graft as well as coronary artery. ISDN spray was expected to be useful for the solution of graft spasm and rapid abortion of anginal attacks even after coronary surgery.
authors.affiliation: Department of Cardiovascular Surgery, Kita-Osaka Hospital.
authors.forename: R
authors.initials: R
authors.lastname: Koike
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Taniura
authors.forename: N
authors.initials: N
authors.lastname: Ohgitani
authors.forename: K
authors.initials: K
authors.lastname: Nada
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012501:Saphenous Vein / Q000187:drug effects / Q000637:transplantation; D013895:Thoracic Arteries / Q000187:drug effects / Q000637:transplantation; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D007548:Isosorbide Dinitrate