title: Comparative bioavailability of rectal and oral formulations of chloroquine.
abstract: The relative bioavailability of chloroquinone in Witepsol H15 suppositories can vary between 10 and 53% of the bioavailability of a tablet formulation in adults. Therefore, it is therapeutically not sound to replace chloroquine tablets by a rectal formulation with the same dose.
authors.affiliation: Clinical Pharmacy Department, St. Elisabeth Hospital, Amersfoort, The Netherlands.
authors.forename: M M
authors.initials: MM
authors.lastname: Tjoeng
authors.forename: P H
authors.initials: PH
authors.lastname: Hogeman
authors.forename: H
authors.initials: H
authors.lastname: Kapelle
authors.forename: M L
authors.initials: ML
authors.lastname: De Ridder
authors.forename: H
authors.initials: H
authors.lastname: Verhaar
mesh_terms: D000284:Administration, Oral; D000285:Administration, Rectal; D000328:Adult; D001682:Biological Availability; D002738:Chloroquine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002738:Chloroquine