A deficient function of the antioxidative system of the organism as an aetiopathogenetic factor in psoriasis.
The main idea of a new hypothesis about the aetiopathogenesis of psoriasis concerns the significance of interrelation between pro- and antioxidants, vitamin A-dependent keratin synthesis and proliferation of keratinocytes. On the basis of postulated deregulation in the antioxidative system of the organism, we explain the predisposition, the initiation and pathogenesis of lesions, their persistence and resolution and the operation mechanisms of antipsoriatics.
Popov
I
I
Institute of Medical Immunology, University Hospital Charite, Berlin, Germany.
Lewin
G
G
D000975:Antioxidants / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008954:Models, Biological; D011565:Psoriasis / Q000209:etiology* / Q000628:therapy
D000975:Antioxidants