Late effects of X-irradiation on haemopoietic stem cells in CBA/H mice.
CBA/H male mice have been used to study the recovery of haemopoietic stem cells following 3 Gy whole-body X-irradiation. Despite significant proliferation haemopoietic stem cells (measured as spleen colony-forming units or CFU-S) did not recover to control values and their numbers remained sub-optimal at 600 days post-irradiation. At this time there were significant increases in both proliferation and self-renewal characteristics of the CFU-S but no impairment of the capacity of bone marrow cells to rescue and repopulate lethally irradiated transplant recipients.
Lorimore
S A
SA
Leukaemia Research Fund, MRC Radiobiology Unit, Didcot, Oxon, U.K.
Wright
E G
EG
D000818:Animals; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000401:mortality; D015996:Survival Rate; D013997:Time Factors