Reversible pathologic jealousy (Othello syndrome) associated with amantadine.
We describe a case of pathologic jealousy (Othello syndrome) in a patient with Parkinson disease, which abated after discontinuing amantadine. We indicate that early recognition and treatment of the syndrome in this disease may avert physical violence. We also believe that our report further suggests a link between this specific behavioral disorder and dopaminergic activity.
McNamara
P
P
Department of Neurology, Boston University School of Medicine, MA.
Durso
R
R
D000368:Aged; D000547:Amantadine / Q000008:administration & dosage / Q000009:adverse effects*; D003702:Delusions / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D007578:Jealousy; D008297:Male; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000188:drug therapy* / Q000523:psychology; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000523:psychology; D013577:Syndrome
D000547:Amantadine