title: [The role of microbial toxic substances in the pathogenesis of acute intestinal infections].
abstract: The authors suggest a syndromal approach to the acute intestinal infection pathogenesis provoked by gram-negative bacteria. A brief review of the achievements in the field of pathogenicity of infectious agents is given on the basis of which a conclusion is drawn about the main role of toxins in the clinical manifestation determining the principal syndromes in acute intestinal infections, i. e. diarrhea and inflammation. A pathogenetic syndromal classification of acute intestinal infections is forwarded which allows a practitioner to choose a pathogenetic therapy. The classification is useful for the pharmacologists as well searching for the methods of detoxification.
authors.forename: N B
authors.initials: NB
authors.lastname: Shalygina
mesh_terms: D000208:Acute Disease; D001419:Bacteria / Q000472:pathogenicity; D001422:Bacterial Adhesion; D001424:Bacterial Infections / Q000209:etiology* / Q000382:microbiology; D004731:Endotoxins / Q000633:toxicity; D004768:Enterotoxins / Q000633:toxicity*; D005098:Exotoxins / Q000633:toxicity; D006801:Humans; D007410:Intestinal Diseases / Q000209:etiology* / Q000382:microbiology
chemical_list: D004731:Endotoxins; D004768:Enterotoxins; D005098:Exotoxins
vernacular_title: O roli mikrobnykh toksicheskikh substantsiĭ v patogeneze ostrykh kishechnykh infektsiĭ.