Comparison of insulin analogue B9AspB27Glu and soluble human insulin in insulin-treated diabetes.
Postprandial plasma glucose excursions and plasma levels of free insulin after subcutaneous bolus injection of a rapidly absorbed monomeric insulin analogue (B9AspB27Glu) or soluble human insulin ('Actrapid HM' U100) were studied in six insulin-treated diabetic subjects. 10 U actrapid or an equimolar amount of the analogue were injected, in random order with an interval of 1 week, immediately before a 500 kcal test meal. Basal insulin levels were similar on the 2 study days (mean 74.1 [SE 5.1] pmol/l, actrapid; 79.7 [13.0] pmol/l, analogue). After injection of actrapid plasma free insulin levels rose slowly, reaching a plateau by 105 min at 222 (19) pmol/l. Injection of the analogue resulted in a rapid early peak at 30 min (798 [112] pmol/l), and levels were significantly higher than those after actrapid between 15 and 210 min. The more physiological plasma insulin levels achieved with the analogue were accompanied by a substantial reduction in postprandial plasma glucose excursions; the integrated area under the incremental plasma glucose curve was 45% lower after the analogue than after actrapid.
Kang
S
S
Diabetes Research Unit, University of Wales College of Medicine, Cardiff, UK.
Owens
D R
DR
Vora
J P
JP
Brange
J
J
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D004341:Drug Evaluation; D004435:Eating; D006801:Humans; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood* / Q000627:therapeutic use; D061389:Insulin, Regular, Pork; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D061389:Insulin, Regular, Pork; C058172:insulin, Asp(B9)-Glu(B27)-; C000006:insulin, neutral