Dissociation between the effect of aceclidine on outflow facility and accommodation.
The dose/effect relationships for intracameral doses of aceclidine HCl and pilocarpine HCl on total facility of outflow and accommodative amplitude were compared in the cynomolgus monkey eye in vivo. The largest dose of aceclidine tested (20 micrograms), resulted in an average increase of 270% in outflow facility, whereas accommodation was limited to an average of 5 diopters. In contrast, 20 micrograms of intracameral pilocarpine (which is submaximal in increasing facility) resulted in an average of 19 diopters of accommodation. These results provide further evidence for a dissociation between the accommodative and outflow facility functions of the ciliary muscle.
Erickson-Lamy
K
K
Howe Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston 02114.
Schroeder
A
A
D000065:Accommodation, Ocular / Q000187:drug effects*; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D008252:Macaca fascicularis; D010862:Pilocarpine / Q000008:administration & dosage / Q000494:pharmacology; D011812:Quinuclidines / Q000008:administration & dosage / Q000494:pharmacology*
D011812:Quinuclidines; D010862:Pilocarpine