Fluorophotometric evaluation of experimental blood-aqueous barrier disruption in dogs.
A protocol for performing slit-lamp fluorophotometry of the anterior chamber in dogs was established. The technique was then used to develop a model of blood-aqueous barrier disruption that can be used for comparative testing of ophthalmic anti-inflammatory drugs. It was determined that barrier disruption induced by a slow, controlled paracentesis of a small volume of aqueous humor may provide the most reliable model for drug testing. Additionally, fluorophotometry proved to be a sensitive and accurate means of detecting breakdown of the blood-aqueous barrier.
Ward
D A
DA
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Ferguson
D C
DC
Kaswan
R L
RL
Green
K
K
Bellhorn
R W
RW
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D002199:Capillary Permeability; D004285:Dogs / Q000378:metabolism*; D005260:Female; D015590:Fluorophotometry / Q000662:veterinary; D008297:Male