Pharmacokinetics and synovial fluid concentrations of cephapirin in calves with suppurative arthritis.
Six calves with suppurative arthritis were given a single IM injection of sodium cephapirin at a dosage of 10 mg/kg of body weight. Cephapirin concentrations were serially measured in serum and in normal and suppurative synovial fluid over a 24-hour period. Mean peak serum concentration was 6.33 microliters/ml at 20 minutes after injection. The highest cephapirin concentrations in normal and suppurative synovial fluid were 1.68 and 1.96 micrograms/ml, respectively, 30 minutes after injection. Overall mean cephapirin concentration in normal synovial fluid for the first 4 hours (1.04 +/- 0.612 micrograms/ml) was not significantly different from that in suppurative synovial fluid (0.88 +/- 0.495 micrograms/ml; P greater than 0.05). Elimination half-life was 0.60 hours and clearance was 1,593 ml/h/kg.
Brown
M P
MP
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136.
Gronwall
R R
RR
Pattio
N
N
Poulos
P W
PW
Houston
A E
AE
D000818:Animals; D001170:Arthritis, Infectious / Q000378:metabolism / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism*; D002514:Cephapirin / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007958:Leukocyte Count / Q000662:veterinary; D013582:Synovial Fluid / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*
D002514:Cephapirin