Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere.
Krohn
A
A
Roche Products Ltd., Welwyn Garden City, Hertfordshire, United Kingdom.
Redshaw
S
S
Ritchie
J C
JC
Graves
B J
BJ
Hatada
M H
MH
D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D005021:Ethylamines / Q000378:metabolism / Q000494:pharmacology; D017320:HIV Protease Inhibitors; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D005021:Ethylamines; D017320:HIV Protease Inhibitors