title: The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats.
abstract: Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.
authors.affiliation: Laboratory of Neuropathology, University of Miami/Jackson Memorial Hospital, FL.
authors.forename: I
authors.initials: I
authors.lastname: Ducis
authors.forename: L O
authors.initials: LO
authors.lastname: Norenberg
authors.forename: M D
authors.initials: MD
authors.lastname: Norenberg
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000378:metabolism*; D001570:Benzodiazepinones / Q000378:metabolism; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000378:metabolism*; D003292:Convulsants / Q000378:metabolism; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*
chemical_list: D001570:Benzodiazepinones; D003292:Convulsants; D011963:Receptors, GABA-A; C028513:4'-chlorodiazepam