Molecular studies on trypanothione reductase, a target for antiparasitic drugs.
Trypanosoma and Leishmania are parasitic protozoa that cause a variety of diseases, which include African sleeping sickness and oriental sore. Attempts to determine pharmaceutically exploitable differences between host and parasite biochemistry have identified the unique trypanothione pathway as a possible target. This pathway includes the enzyme trypanothione reductase, the parasite analogue of glutathione reductase.
Walsh
C
C
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Bradley
M
M
Nadeau
K
K
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D015195:Drug Design; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism; D007891:Leishmania / Q000187:drug effects / Q000378:metabolism; D009154:Mutation; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors* / Q000235:genetics; D013095:Spermidine / Q000031:analogs & derivatives / Q000378:metabolism; D014345:Trypanosoma / Q000187:drug effects / Q000378:metabolism
D000981:Antiprotozoal Agents; C044809:trypanothione; D009247:NADH, NADPH Oxidoreductases; C049608:trypanothione reductase; D005978:Glutathione; D013095:Spermidine