title: Presence of both stimulating and blocking types of TSH-receptor antibodies in sera from three patients with primary hypothyroidism.
abstract: A case report of three patients with primary hypothyroidism who had potent TSH-binding inhibitor immunoglobulins (TBII) and both thyroid stimulating (TSAb) and thyroid stimulation-blocking antibodies (TSBAb) has been described. Two patients displayed symptoms and signs indistinguishable from those in primary myxoedema (cases 1 and 2), and another patient had a history of Graves' disease (case 3). TBII, TSAb and TSBAb activities were 90.0, 1084.2 and 94.5% in case 1, 91.5, 826.6 and 95.8% in case 2, 76.0, 230.0 and 95.0% in case 3, respectively (normal range, less than 11.0%, less than 145.0 and less than 22.0%, respectively. The results indicate that both stimulating and blocking types of TSH-receptor antibodies exist in these patients. The possible mechanism whereby hypothyroidism developed has been discussed.
authors.affiliation: Department of Nuclear Medicine, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kasagi
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: K
authors.initials: K
authors.lastname: Goshi
authors.forename: J
authors.initials: J
authors.lastname: Takamatsu
authors.forename: A
authors.initials: A
authors.lastname: Hidaka
authors.forename: H
authors.initials: H
authors.lastname: Hatabu
authors.forename: T
authors.initials: T
authors.lastname: Misaki
authors.forename: Y
authors.initials: Y
authors.lastname: Iida
authors.forename: K
authors.initials: K
authors.lastname: Kuma
authors.forename: J
authors.initials: J
authors.lastname: Konishi
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology*; D018828:Immunoglobulins, Thyroid-Stimulating; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000276:immunology
chemical_list: D000906:Antibodies; D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating