title: Correlation between radiological and functional findings in workers exposed to chrysotile asbestos.
abstract: The relationship between the extent of respiratory disease from chest radiographs and the severity of functional impairment was assessed in 185 workers with long-term exposure to asbestos in an asbestos-cement factory. The workers were divided into seven subgroups according to functional abnormality findings (restrictive, obstructive, mixed restrictive-obstructive, reduced diffusion capacity, increased diffusion capacity, small airway disease and normal). Restrictive functional abnormality was present in 29% of the workers, obstructive and mixed in 3% small airway disease in 4%, reduced diffusion capacity in 4% increased diffusion capacity in 7%, while the remaining 49% were normal. The subjects with radiological diffuse pleural disease were characterized by FVC reduction, whereas in those with mixed pleural-parenchymal radiological abnormalities both FVC and DLCO were reduced. FVC and DLCO decrements correlated well with the increasing grades of profusion according to the ILO classification. In the group of workers with normal chest radiographs and normal spirometry, a decrease or increase in lung diffusion capacity for CO (DLCO) was an isolated finding. In addition, a correlation existed between the length of exposure and functional parameters (reduced FVC and DLCO, while FEV1/FVC increased with longer exposure). The study shows that reduced lung function indices can be found in subjects without radiological evidence for parenchymal asbestosis (ILO grade 1/1 profusion or greater). The results suggest that asbestos exposure, in addition to lung diffusion capacity decrease, can be accompanied by an increase in lung diffusion capacity.
authors.affiliation: Pulmonary Division Firule Hospital, Split, Yugoslavia.
authors.forename: J
authors.initials: J
authors.lastname: Tocilj
authors.forename: Z
authors.initials: Z
authors.lastname: Dujić
authors.forename: S
authors.initials: S
authors.lastname: Boschi
authors.forename: M
authors.initials: M
authors.lastname: Sarić
mesh_terms: D000328:Adult; D001194:Asbestos / Q000009:adverse effects*; D017632:Asbestos, Serpentine; D001195:Asbestosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D010995:Pleural Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D011859:Radiography; D012129:Respiratory Function Tests
chemical_list: D017632:Asbestos, Serpentine; D001194:Asbestos