Testicular autoregulation: possible role for 7-alpha-hydroxylated androgens.
Pituitary FSH secretion appears to be supported by a factor distinct from the gonadotropin-releasing hormone (Gn-RH). The ratio of FSH to LH is positively correlated with testicular steroid 5 alpha-reductase activity and negatively correlated with testicular steroid 7 alpha-hydroxylase under various experimental conditions. Literature describing interactions among the above and other factors is reviewed here.
Mittler
J C
JC
Medical Service, US Department of Veterans Affairs, East Orange, New Jersey 07019.
D000728:Androgens / Q000502:physiology*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D013250:Steroid Hydroxylases / Q000378:metabolism; D013737:Testis / Q000502:physiology*
D000728:Androgens; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; C029009:steroid hormone 7-alpha-hydroxylase