[Detection of early tumor reactions in irradiation of tumors of the gastrointestinal tract by measuring the onco-radiogenic enzyme peak of glucosephosphate isomerase].
In 43 patients with oesophageal, pancreatic and rectal carcinoma blood samples were taken after the first irradiation and the activity of the glycolytic enzyme glucose-6-phosphate isomerase was measured. In all patients GPI peaks occurred at reproducible time intervals. The height of the enzyme peak occurring 15.5 to 19.5 hours p.irr. was significantly dependent on tumour size and irradiation dose. The frequency of a late occurring enzyme peak was dependent on the presence of regional lymph node metastases. Possible sources of the enzyme peaks are discussed from a radiobiological point of view and the meaning of such enzyme peaks for the optimization of radiation therapy is pointed out.
Tunak
D
D
Klinik und Poliklinik für Onkologie, Bereich Medizin, Humboldt-Universität zu Berlin, Bundesrepublik Deutschland.
Below
M
M
Dallüge
K H
KH
Kuchenbecker
F
F
D000230:Adenocarcinoma / Q000201:enzymology / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000532:radiotherapy*; D002470:Cell Survival / Q000528:radiation effects; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000532:radiotherapy*; D005260:Female; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000201:enzymology / Q000532:radiotherapy*; D011379:Prognosis; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000201:enzymology / Q000532:radiotherapy*
D014408:Biomarkers, Tumor; D005956:Glucose-6-Phosphate Isomerase
Nachweis früher Tumorreaktionen bei Bestrahlung von Tumoren des Magen-Darm-Traktes durch Messung des onkoradiogenen Enzympeaks der GPI.