[Scavenging effects of sodium ferulate and 18 beta-glycyrrhetic acid on oxygen free radicals].
The scavenging effects of sodium ferulate (SF) and glycyrrhetic acid (GA) on oxygen free radicals were studied by using spin trapping technique and chemiluminescence (CL) methods. SF 0.3 mmol/L and GA 0.3 mmol/L effectively scavenged oxygen free radicals produced by phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMN), but had no effect on the oxygen consumption by PMN, measured with spin probe oxymetry. In 3 cell-free oxygen free radical generating systems, both SF and GA showed a remarkably scavenging effects on O2- and OH.. SF 30 mumol/L and GA 30 mumol/L prominently inhibited the CL response of PMA-stimulated PMN. The results demonstrated that SF and GA are oxygen free radical scavengers.
Ju
H S
HS
Institute of Biophysics, Chinese Academy of Sciences, Beijing.
Li
X J
XJ
Zhao
B L
BL
Hou
J W
JW
Han
Z W
ZW
Xin
W J
WJ
D003373:Coumaric Acids / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers; D005609:Free Radicals; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism*
D003373:Coumaric Acids; D016166:Free Radical Scavengers; D005609:Free Radicals; C004999:ferulic acid; D006034:Glycyrrhetinic Acid; D010100:Oxygen