Age-dependent effects of ischemia and reperfusion on cardiac function and Ca2+ transport in myocardium.
Experiments on isolated hearts from adult and old rats have proved an age-dependent decrease in the resistance of contractile function and cardiac rhythm to ischemia and reperfusion. The restriction of coronary flow by 70% produced significant changes in various links of the Ca2+ transport system (an increase in sarcolemmal permeability for Ca2+ and a decrease in Ca(2+)-accumulating capacity of sarcoplasmic reticulum included). These changes, more marked in old animals, seemed to play an important role in the mechanisms of disturbances in cardiac function following coronary insufficiency.
Frolkis
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VV
Institute of Gerontology, USSR Academy of Medical Sciences, Kiev.
Frolkis
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RA
Mkhitarian
L S
LS
Fraifeld
V E
VE
D000375:Aging / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology*; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D066298:In Vitro Techniques; D009200:Myocardial Contraction; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D003402:Creatine Kinase; D002118:Calcium