Polymorphisms in the VK gene patterns of rheumatoid arthritis patients and control individuals.
Restriction nuclease digests of DNAs from rheumatoid arthritis patients and control persons were studied by blot hybridization using immunoglobulin VK gene probes of subgroups I-III. Two restriction fragment length polymorphisms (RFLP) were detected in Bg1II digests with a VKI gene probe. One of the RFLPs is linked to rheumatoid arthritis with a relative risk of 5 (p less than 0.01). The observation may be of pathogenetic interest.
Meindl
A
A
Institut für Physiologische Chemie, Universität München, BRD.
Kellner
H
H
Schattenkirchner
M
M
Zachau
H G
HG
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D004247:DNA; D015342:DNA Probes; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
D015342:DNA Probes; D007126:Immunoglobulin Allotypes; D007145:Immunoglobulin kappa-Chains; D004247:DNA