title: Advantages of handsewn over stapled bowel anastomosis.
abstract: Bowel anastomoses are conventionally performed using a handsewn technique or a stapling device. Each has potential benefits and disadvantages. The most clinically significant complications of the bowel anastomosis are anastomotic leakage and stricture formation. The indices of healing and tissue cohesion were compared dynamically over time in 24 dogs randomized to undergo either a standard two-layer handsewn anastomosis or a stapled anastomosis with the Premium CEEA (United States Surgical Corporation, Norwalk, CT). Animals were sacrificed at 1, 4, 7, and 28 days postoperatively. Each anastomosis was evaluated for anastomotic index, burst pressure, collagen content, and histologic appearance. The anastomotic index was similar on postoperative day (POD) 1, 4, and 7; but on day 28 all handsewn anastomoses had larger diameters than the widest CEEA anastomosis. Burst pressure was higher in handsewn anastomoses at all intervals. Collagen content tended to be higher on POD 7 in the CEEA anastomoses. Histological evaluation showed more complete epithelialization and less inflammation in handsewn anastomoses on POD 28. The higher level of collagen in the CEEA anastomoses on POD 7 may be implicated in the tendency toward stricture formation found with this type of anastomosis. This study demonstrates that the greater speed and ease of the stapled anastomosis is offset by the greater strength, reduced tendency to stricture, and more complete healing of the handsewn anastomosis.
authors.affiliation: Department of Surgery, Veterans Administration Medical Center, Washington, DC 20422.
authors.forename: A J
authors.initials: AJ
authors.lastname: Dziki
authors.forename: M D
authors.initials: MD
authors.lastname: Duncan
authors.forename: J W
authors.initials: JW
authors.lastname: Harmon
authors.forename: N
authors.initials: N
authors.lastname: Saini
authors.forename: R A
authors.initials: RA
authors.lastname: Malthaner
authors.forename: K S
authors.initials: KS
authors.lastname: Trad
authors.forename: M T
authors.initials: MT
authors.lastname: Fernicola
authors.forename: F
authors.initials: F
authors.lastname: Hakki
authors.forename: R M
authors.initials: RM
authors.lastname: Ugarte
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D003106:Colon / Q000601:surgery; D004285:Dogs; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000473:pathology / Q000502:physiology / Q000601:surgery*; D008297:Male; D011182:Postoperative Care; D011897:Random Allocation; D013528:Surgical Staplers; D013536:Suture Techniques; D013718:Tensile Strength
chemical_list: D003094:Collagen