title: [Synthesis, structure and properties of rubomycin derivatives of mono- and oligonucleotides].
abstract: Daunomycin derivatives of pT(DT) and oligodeoxynucleotides were synthesized using reactive zwitter-ionic 4-N,N-dimethylaminopyridine derivatives of the terminal phosphate group. Daunomycin oligodeoxynucleotide analogues form more stable complementary complexes than the corresponding non-modified oligonucleotides. Both one- and two-dimensional (2D NOESY and 2D COSY) NMR spectra of DT were recorded and the proton signals assigned. From the detected cross-relaxation between H6 of thymidine and H1', H2', H2" of the carbohydrate residue of daunomycin it was concluded that, in DMSO, the DT molecule has a rather stable conformation, apparently due to the stacking interaction between the mononucleotide and daunomycin residues.
authors.forename: T S
authors.initials: TS
authors.lastname: Godovikova
authors.forename: V F
authors.initials: VF
authors.lastname: Zarytova
authors.forename: S G
authors.initials: SG
authors.lastname: Lokhov
authors.forename: T V
authors.initials: TV
authors.lastname: Mal'tseva
authors.forename: D S
authors.initials: DS
authors.lastname: Sergeev
mesh_terms: D003630:Daunorubicin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
chemical_list: D003630:Daunorubicin
vernacular_title: Sintez, struktura i svoĭstva rubomitsinovykh proizvodnykh mono- i oligonukleotidov.