HLA-DP, -DQ and -DR RFLP types in south Indian insulin-dependent diabetes mellitus patients.
The frequencies of HLA-DP, DQ and DR RFLP types are compared between insulin-dependent diabetes mellitus (IDDM) patients and healthy controls in the South Indian population. There are no significant differences in the frequencies of any of the DPA. DPB haplotypes, when allowance is made for multiple comparisons. The individual frequencies of two novel alleles, designated "DPA*B" and "DPB*B", however, are significantly higher in controls than in patients, suggesting that these alleles are protective against IDDM. A negative association with DRw15 (DR2). Dw12 is also observed. The positive association with DPw3/6 RFLPs previously observed in White Australians is not present in South Indians. This difference may be due either to undetected heterogeneity within allelic classes or to different linkage disequilibrium patterns between the populations.
Easteal
S
S
Human Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra.
Viswanathan
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M
Serjeantson
S W
SW
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency / Q000235:genetics / Q000276:immunology; D006682:HLA-DP Antigens / Q000235:genetics* / Q000276:immunology; D006683:HLA-DQ Antigens / Q000235:genetics* / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007194:India; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens