[Cytomegalovirus chorioretinitis: unusual and severe complications in renal transplantation. Importance of early diagnosis and prolonged treatment with DHPG].
We report here an observation of severe chorio-retinitis in a kidney transplant patient presenting with a primary cytomegalovirus infection. This complication occurred three months after transplantation, following an aggressive treatment for an acute rejection episode (OKT3 associated with methylprednisolone bolus). The clinical manifestation was blurred vision without other evidence of viral infection. A rapid diagnosis of chorio-retinitis was achieved based on ophtalmoscopic findings and biological results. A prolonged treatment with DHPG was effective in halting the very progression involving the left macula and the righ peripheral retina.
Chong
G
G
Service de Néphrologie, Hôpital Lapeyronie, Montpellier.
Mourad
G
G
Lévy
P
P
Nedelec
G
G
Giudicelli
C
C
Mion
C
C
D000328:Adult; D002825:Chorioretinitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D003586:Cytomegalovirus Infections; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male
D015774:Ganciclovir
Chorio-rétinite à cytomégalovirus: complication rare et grave chez le transplanté rénal. Intérêt du diagnostic précoce et du traitement prolongé par le DHPG.