title: [Effects of flutropium bromide, a new anti-asthma drug, alone or in combination with salbutamol, aminophylline and disodium cromoglycate on the acetylcholine induced bronchoconstriction].
abstract: Effects of flutropium bromide, a new bronchodilator with an anticholinergic action, alone or in combination with other antiasthma drugs were investigated in guinea pigs by using an index of inhibition of the acetylcholine (ACh)-induced bronchoconstriction. Single inhalation of flutropium bromide (0.0003%) into the airways of guinea pigs inhibited the ACh (i.v.)-induced bronchoconstriction without changing the fall in blood pressure induced by ACh. When salbutamol (3 micrograms/kg, i.v.), aminophylline (5 mg/kg, i.v.) or disodium cromoglycate (10 mg/kg, i.v.) was administered in combination with flutropium bromide (0.0003%), bronchodilation was enhanced as compared with single administration of the respective antiasthma drugs. From the above results, it is indicated that inhalation of flutropium bromide provides a more efficient bronchodilation in combination with other antiasthma drugs that possess different mechanisms of antiasthma effects.
authors.affiliation: Central Research Laboratory, SS Pharmaceutical Co., Ltd., Chiba, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mizuno
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Ohno
authors.forename: M
authors.initials: M
authors.lastname: Misawa
mesh_terms: D000109:Acetylcholine; D000280:Administration, Inhalation; D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D000628:Aminophylline / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D001286:Atropine Derivatives / Q000008:administration & dosage / Q000627:therapeutic use*; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D007275:Injections, Intravenous; D008297:Male
chemical_list: D001286:Atropine Derivatives; D006634:Histamine H1 Antagonists; D000628:Aminophylline; C039778:flutropium bromide; D000109:Acetylcholine; D004205:Cromolyn Sodium; D000420:Albuterol