Improvement of cognitive function by MAO-B inhibitor L-deprenyl in aged rats.
This study evaluated the ability of the selective MAO-B inhibitor, L-deprenyl, to reverse cognitive impairments appearing in aged rats, using the reference memory, Morris Water Maze paradigm. L-Deprenyl significantly improved learning and memory deficits associated with old age in doses of 1.25 and 5 mg/kg PO (escape latency measure) and doses of 1.25, 2.5 and 5 mg/kg PO (path length measure). L-Deprenyl also improved reversal learning impairments in doses of 1.25, 2.5 and 5 mg/kg PO, as expressed by the escape latency measure. The data suggest that L-deprenyl possesses potential cognitive enhancement abilities probably due to an increase in dopaminergic activity.
Brandeis
R
R
Department of Pharmacology, Israel Institute for Biological Research, Ness-Ziona.
Sapir
M
M
Kapon
Y
Y
Borelli
G
G
Cadel
S
S
Valsecchi
B
B
D000374:Aggression / Q000187:drug effects; D000375:Aging / Q000523:psychology; D000818:Animals; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012642:Selegiline / Q000009:adverse effects / Q000494:pharmacology*; D013028:Space Perception / Q000187:drug effects; D013550:Swimming
D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline