[Visco-elastic properties of common carotid artery in treated hypertension].
It is now possible to measure clinically by a non-invasive method systolo-diastolic variations of the internal diameter of large arteries over 4 to 10 cardiac cycles with an original vascular echo-tracking device using Doppler shift. By the means of a transversal study of healthy subjects and patients followed up in the hypertension clinique, the authors set out to determine whether long-term non-specific antihypertensive treatment could, by correcting the blood pressure, also normalise the vascular changes encountered in hypertension. This study compared 46 normotensive subjects (Group I), 25 essential hypertensive patients with normal blood pressure recordings after at least 3 months' treatment (Group II) and 56 untreated essential hypertensive patients of the same average age (range 24 to 78 years). The common carotid artery was chosen for study of its geometry (internal diastolic diameter: Dd) and function (relative systolic expansion Ds-Dd/Dd; Perterson's elastic modulus; cross sectional compliance). The arterial diameter increased significantly with age in all three patients groups. In patients under 60 years of age, the diameter, corrected for age and sex, was significantly greater in Group II than in Group I, and similar in Groups II and III. This suggests that in spite of correcting blood pressure by long-term therapy (4.1 +/- 4.1 years), the internal diameter of a large artery such as the common carotid artery remains increased, which is in favour of the persistence of structural arterial changes rather than a prolonged vasodilator effect of the antihypertensive agents used.(ABSTRACT TRUNCATED AT 250 WORDS)
Laurent
S
S
Service de pharmacologie, hôpital Broussais, Paris.
Arcaro
G
G
Jondeau
G
G
Girerd
X
X
Hoeks
A
A
Safar
M
M
D000328:Adult; D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure; D002339:Carotid Arteries / Q000503:physiopathology*; D004548:Elasticity; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008875:Middle Aged; D014654:Vascular Patency / Q000187:drug effects
D000959:Antihypertensive Agents
Propriétés visco-élastiques de la carotide primitive. L'hypertendu traité.