title: Effects of tobacco smoke on respiratory epithelial clearance of DTPA and on lung histology in rats.
abstract: The respiratory epithelial clearance of 99mTc-(DTPA) diethylenetriamine penta-acetate (RC-DTPA) was measured in rats before and after sham or cigarette smoke exposures. RC-DTPA was increased by cigarette smoke exposure (p less than 0.001); the amount and duration of the exposure had no significant effect. In smoker animals, the number of bronchoalveolar macrophages was decreased after one or five smoke exposures a day for one day (p less than 0.001) and the number of bronchoalveolar neutrophils was increased after five exposures a day for ten days (p less than 0.001). No abnormality was found in the lung parenchyma on light microscopy. We conclude that in rats RC-DTPA is increased by exposure to tobacco smoke, whatever the amount and duration of exposure; however, no gross parenchymal lung abnormality explains the increase in RC-DTPA.
authors.affiliation: Université René Descartes, Hôpital Ambroise Paré, Boulogne, France.
authors.forename: M
authors.initials: M
authors.lastname: Mordelet-Dambrine
authors.forename: G
authors.initials: G
authors.lastname: Leguern-Stanislas
authors.forename: T C
authors.initials: TC
authors.lastname: Chinet
authors.forename: L
authors.initials: L
authors.lastname: Barritault
authors.forename: J
authors.initials: J
authors.lastname: Chrétien
authors.forename: G J
authors.initials: GJ
authors.lastname: Huchon
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004848:Epithelium / Q000378:metabolism; D008168:Lung / Q000033:anatomy & histology / Q000378:metabolism*; D008264:Macrophages; D008297:Male; D009504:Neutrophils; D004369:Pentetic Acid / Q000493:pharmacokinetics*; D010539:Permeability; D010947:Plants, Toxic; D051381:Rats; D011919:Rats, Inbred Strains; D012906:Smoke; D014026:Nicotiana
chemical_list: D012906:Smoke; D004369:Pentetic Acid