Neuroleptic-associated autoantibodies. A prevalence study.
Antinuclear antibodies (ANA), antiphospholipid antibodies (APA), rheumatoid factor (RF), and immunoglobulin (Ig) M levels were determined in 184 male chronic psychiatric patients on long-term therapy with neuroleptics, and in 35 age-matched normal male controls. The prevalence of one or more of these autoantibodies was 70% in the neuroleptic-treated patients and 9% in the normal controls. Polyclonal IgM elevation was frequently seen among patients treated with phenothiazines. There was a significant correlation between the presence of ANA, APA, and RF; ANA and APA were more frequently associated with CPZ therapy, but the prevalence of RF was high in all treatment groups. These findings suggest that antibodies against the Fc fragment of IgG are the most common autoantibody associated with neuroleptics. Alternatively, the presence of RF could be a common finding in patients with neuropsychiatric disorders.
Canoso
R T
RT
Hematology-Oncology Section, Brockton/West Roxbury Department of Veterans Affairs Medical Center, MA 02401.
de Oliveira
R M
RM
Nixon
R A
RA
D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000139:chemically induced*; D002746:Chlorpromazine / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy*; D012307:Risk Factors
D014150:Antipsychotic Agents; D001323:Autoantibodies; D002746:Chlorpromazine