Inhibition of endogenous leukotriene-mediated lung anaphylaxis in guinea pigs by a novel receptor antagonist ONO-1078.
The inhibitory effect of ONO-1078, a novel leukotriene (LT) receptor antagonist, was investigated on guinea pig lung anaphylaxis in vitro and in vivo. It was demonstrated that this compound could inhibit the late phase of contractile responses in Schultz-Dale reactions and endogenous LT-mediated bronchoconstrictions in passively sensitized guinea pigs, in a dose-dependent fashion, implying its clinical usefulness in the treatment of human bronchial asthma.
Ishii
A
A
Department of Medicine and Physical Therapy, University of Tokyo, Japan.
Nakagawa
T
T
Nambu
F
F
Motoishi
M
M
Miyamoto
T
T
D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D016084:Bronchoconstriction / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology* / Q000627:therapeutic use; D006168:Guinea Pigs; D008168:Lung / Q000276:immunology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011971:Receptors, Immunologic / Q000187:drug effects*; D018077:Receptors, Leukotriene; D013189:SRS-A / Q000037:antagonists & inhibitors*
D002867:Chromones; D011971:Receptors, Immunologic; D018077:Receptors, Leukotriene; D013189:SRS-A; C047681:pranlukast