Synthesis and anticonvulsant activity of some benzopyranone imino derivatives of GABA and related compounds.
The synthesis of some 5-hydroxy-4-imino-2,3-dihydrobenzopyran derivatives of GABA and alkylamines is described. The products were tested for their GABA-receptor binding and anticonvulsant activity in mice. Some compounds showed anticonvulsant activity. No binding to GABA receptors was observed.
Arnoldi
A
A
Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano.
Merlini
L
L
Quadri
M L
ML
Bonsignori
A
A
Melloni
P
P
Varasi
M
M
D015097:3-Mercaptopropionic Acid / Q000037:antagonists & inhibitors; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D001640:Bicuculline / Q000037:antagonists & inhibitors; D002839:Chromans / Q000138:chemical synthesis* / Q000494:pharmacology; D007097:Imines / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010852:Picrotoxin / Q000037:antagonists & inhibitors; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
D015097:3-Mercaptopropionic Acid; D000927:Anticonvulsants; D001640:Bicuculline; D002839:Chromans; D007097:Imines; D010433:Pentylenetetrazole; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid