title: Failure of peripheral arterial balloon angioplasty: does platelet deposition play a role?
abstract: The pathophysiological response to peripheral percutaneous transluminal balloon angioplasty in 20 patients was investigated using 111-Indium labelled platelets. Platelet deposition was quantified by measuring the degree of radioactivity uptake at angioplasty and control sites using a computer linked system and expressing the uptake as a ratio of angioplasty/control. Following platelet labelling, scans were performed before angioplasty and at 1, 24 and 48 h after angioplasty. To assess patency of the angioplasty, ankle brachial Doppler pressure indices were performed and supported by repeat angiograms if doubt of patency existed. All patients were followed-up at 1 week, 1 month and 6 months to correlate the degree of early platelet uptake with failure. The mean +/- sem platelet radioactivity ratio at the angioplasty site increased from 1.1 +/- 0.1 prior to the procedure to a peak of 2.1 +/- 0.3 at 1 h (p less than 0.01), 1.6 +/- 0.2 at 24 h (p less than 0.05), and 1.7 +/- 0.3 at 48 h (p less than 0.05). Angioplasties that failed within 6 months tended to have a higher maximum early platelet uptake (3.1 +/- 0.6) compared to successful angioplasties (1.9 +/- 0.3) but the difference was not significant in the numbers studied. This study provides a suitable model to assess the role of platelet accumulation in angioplasty failure and the influence of various antiplatelet regimes.
authors.affiliation: Department of Surgery, Bristol Royal Infirmary, U.K.
authors.forename: K R
authors.initials: KR
authors.lastname: Poskitt
authors.forename: A
authors.initials: A
authors.lastname: Harwood
authors.forename: D J
authors.initials: DJ
authors.lastname: Scott
authors.forename: W D
authors.initials: WD
authors.lastname: Jeans
authors.forename: E R
authors.initials: ER
authors.lastname: Davies
authors.forename: R N
authors.initials: RN
authors.lastname: Baird
authors.forename: M
authors.initials: M
authors.lastname: Horrocks
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007511:Ischemia / Q000097:blood* / Q000000981:diagnostic imaging / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D010974:Platelet Aggregation / Q000502:physiology*; D011183:Postoperative Complications / Q000097:blood / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D012008:Recurrence; D013927:Thrombosis / Q000097:blood* / Q000000981:diagnostic imaging
chemical_list: D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C032950:indium oxine; D015125:Oxyquinoline