title: [Non-Hodgkin's lymphoma in childhood. Review of 33 cases].
abstract: A retrospective study was performed of 33 cases of non Hodgkin's lymphoma in children diagnosed in our hospital. The mean age was 10 years and there were 24 males and 9 females. The distribution, according to Rappaport's diagnostic classification, was: 11 undifferentiated lymphomas, 9 lymphoblastic lymphomas, 6 diffuse histiocytic lymphomas, and 7 cases of other types. Of the 33 patients, 23 had bulky disease (over 5 cm. in diameter). The mean serum LDH and uric acid values were, respectively, 537 (68-2021) and 6.0 (2.7-19). According to Murphy's staging system, the distribution of the cases was as follows: I (1), II (4), III (12), IV (16). Since this study spreads for a long period, several protocols have been used in the treatment of the group, but most patients received the LSA2-L2 regimen. Complete remission (CR) was achieved in 26 cases (78%), this being 100% of the lymphoblastic lymphomas. After a mean follow-up of 45 months, the actuarial survival is 48.1%, and the disease-free survival of patients attaining CR is 60.4%. The prognostic factors analysed, such as histologic type, stage, and serum LDH showed no statistical significance, probably due to the low number of cases studied.
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Ntra. Sra. de Aránzazu. San Sebastián.
authors.forename: J R
authors.initials: JR
authors.lastname: Furundarena
authors.forename: D
authors.initials: D
authors.lastname: Martínez Busteros
authors.forename: E
authors.initials: E
authors.lastname: Navarro
authors.forename: R
authors.initials: R
authors.lastname: Aginako
authors.forename: A
authors.initials: A
authors.lastname: Manterola
authors.forename: A
authors.initials: A
authors.lastname: Orube
authors.forename: R
authors.initials: R
authors.lastname: Lasa
authors.forename: M A
authors.initials: MA
authors.lastname: Echeveste
authors.forename: I
authors.initials: I
authors.lastname: Egurbide
authors.forename: E
authors.initials: E
authors.lastname: Bengoechea
mesh_terms: D000008:Abdominal Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015993:Life Tables; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D008297:Male; D008479:Mediastinal Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D015996:Survival Rate
vernacular_title: Linfoma no Hodgkin infantil. Revisión de 33 casos.