title: A review of cancer induction by extremely low frequency electromagnetic fields. Is there a plausible mechanism?
abstract: A body of epidemiological evidence suggests an association between residential or occupational exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and an increased incidence of cancer in children and adults. Experimental studies at the whole-animal and cellular level are ambiguous; bioeffects suggestive of a carcinogenic effect have been reported, but a similar volume of negative reports can also be assembled. This literature is critically reviewed based on the hypothesis that the epidemiological results are correct, and asking what plausible mechanism could explain a small increase in the incidence of a range of tumors with a non-specific increased exposure to ELF EMF? We focus on four likely mechanisms: 1) disruption of cell communication, 2) modulation of cell growth via changes in calcium ion flux, 3) activation of specific oncogenic gene sequences, and 4) action as a stress factor operating through disruption of hormonal and immune system tumor control mechanisms. We discuss the implications of epidemiologic and experimental results in the context of hypothetical mechanisms of cancer induction, and suggest experiments likely to help define putative EMF hazards.
authors.affiliation: Information Ventures Inc., Philadelphia, PA 19102.
authors.forename: R B
authors.initials: RB
authors.lastname: Goldberg
authors.forename: W A
authors.initials: WA
authors.lastname: Creasey
mesh_terms: D000328:Adult; D000818:Animals; D002450:Cell Communication; D002455:Cell Division; D002648:Child; D004574:Electromagnetic Fields / Q000009:adverse effects*; D015981:Epidemiologic Factors; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D013312:Stress, Physiological