Nasopharyngeal colonization by nontypeable Hemophilus influenzae in children: the effect of serum bactericidal antibody.
The effect of serum bactericidal antibody on colonization with NTHI was studied in 26 children. Serum bactericidal antibody did not prevent colonization with NTHI in the nasopharynx. Antibody was detected in 53% before, 91% during, and 100% after documented colonization. The log titer of antibody was significantly higher during (1.18 +/- 0.56), p less than 0.002; and after (1.31 +/- 0.29), p greater than 0.001 compared to before colonization (0.49 +/- 0.51). The roles of secretory IgA and normal nasopharyngeal flora in inhibiting pathogenic bacteria are discussed.
Bernstein
J M
JM
Department of Otolaryngology, State University of New York, Buffalo 14214.
Faden
H S
HS
Ogra
P L
PL
D000907:Antibodies, Bacterial / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D001770:Blood Bactericidal Activity / Q000502:physiology; D002675:Child, Preschool; D006193:Haemophilus influenzae / Q000254:growth & development* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007223:Infant; D009305:Nasopharynx / Q000382:microbiology*
D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D007074:Immunoglobulin G