Glutathione-S-transferase-mediated methylthio displacement and turnover in the metabolism of pentachlorothioanisole by rats.
1. The metabolism of pentachlorothioanisole to bis-(methylthio)tetrachlorobenzene was shown to involve turnover of about 50% of the original methylthio group. 2. Metabolites of the displaced methylthio group were methanesulphinic acid and sulphate in the urine, carbon dioxide in the expired air, and unidentified sulphur-containing compounds in the bile.
Mulford
D J
DJ
Department of Biochemistry, North Dakota State University, Fargo 58105.
Bakke
J E
JE
Feil
V J
VJ
D000818:Animals; D001646:Bile / Q000737:chemistry; D001711:Biotransformation; D002247:Carbon Isotopes; D002250:Carbon Radioisotopes; D002722:Chlorobenzenes / Q000493:pharmacokinetics*; D005982:Glutathione Transferase / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013462:Sulfur Radioisotopes
D002247:Carbon Isotopes; D002250:Carbon Radioisotopes; D002722:Chlorobenzenes; D013462:Sulfur Radioisotopes; C031281:pentachloromethylthiobenzene; D005982:Glutathione Transferase