[Impaired glucose tolerance and diabetes mellitus in Ullrich-Turner syndrome. A literature review].
In patients with Ullrich-Turner-syndrome below the age of 40, the frequency of impaired glucose tolerance is about 30%. The prevalence of overt diabetes mellitus, however, is not known, as no studies in older patients are available. There are no indications (islet cell antibodies, HLA-status) for an immunologic disease similar to type-I-diabetes mellitus. The pathogenesis of carbohydrate intolerance in Ullrich-Turner-syndrome therefore remains to be elucidated. So far, no dramatic deterioration has been reported during GH therapy for acceleration of height velocity in girls with the syndrome, however a close surveillance of carbohydrate metabolism during such therapy is advisable.
Holl
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RW
Abteilung Pädiatrie I, Universitäts-Kinderklinik Ulm.
Heinze
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E
D001786:Blood Glucose / Q000737:chemistry*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000209:etiology; D005260:Female; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009634:Noonan Syndrome / Q000097:blood* / Q000150:complications / Q000188:drug therapy
D001786:Blood Glucose; D013006:Growth Hormone
Gestörte Glukosetoleranz und Diabetes mellitus bei Ullrich-Turner-Syndrom. Eine Literaturübersicht.