title: User-friendly method for rapid brain and CSF volume calculation using transaxial MRI images.
abstract: A reliable computer method was developed for straightforward, rapid determination of whole brain and cerebrospinal fluid (CSF) volumes from a set of contiguous transaxial magnetic resonance images. The semiautomatic algorithm used a threshold-guided edge follower. Subtraction of proton-weighted from T2-weighted images was used to highlight CSF. Phantom studies were used for validity assessment. Interrater and intrarater reliability and correlation with manual measurement were excellent. Percent CSF and brain volumes were determined for small groups of Alzheimer's disease, HIV seropositive, obsessive-compulsive disorder, and schizophrenic patients as well as for young and elderly normal controls.
authors.affiliation: Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, MD.
authors.forename: G J
authors.initials: GJ
authors.lastname: Harris
authors.forename: E H
authors.initials: EH
authors.lastname: Rhew
authors.forename: T
authors.initials: T
authors.lastname: Noga
authors.forename: G D
authors.initials: GD
authors.lastname: Pearlson
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000473:pathology; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000295:instrumentation; D002555:Cerebrospinal Fluid / Q000502:physiology*; D006679:HIV Seropositivity / Q000134:cerebrospinal fluid / Q000473:pathology; D015497:HIV-1; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D001523:Mental Disorders / Q000134:cerebrospinal fluid* / Q000473:pathology; D019965:Neurocognitive Disorders / Q000134:cerebrospinal fluid* / Q000473:pathology; D009771:Obsessive-Compulsive Disorder / Q000134:cerebrospinal fluid / Q000473:pathology; D012559:Schizophrenia / Q000134:cerebrospinal fluid / Q000473:pathology; D012984:Software