title: [Cisplatin nephrotoxicity: effects on fractional excretion of sodium and enzymuria].
abstract: The effects (in five therapeutic cycles) of Cisplatin on urinary enzyme excretion (specific markers of tubular damage), fractional excretion of sodium, fractional reabsorption of phosphate, serum Creatinine and creatinine Clearance were assessed in 17 female patients with ovarian carcinoma. An immediate reduction of sodium fractional excretion was observed: this appears a more sensible Cisplatin-nephrotoxicity marker than serum Creatinine and creatinine Clearance. No significant variations were noted in fractional reabsorption of phosphate or urinary Lysozyme and Beta-2-microglobulin but there was a significant increase of other urinary enzymes, confirming the potential nephrotoxicity of DDP treatment.
authors.affiliation: Istituto di Clinica Medica II, Università di Pisa.
authors.forename: C
authors.initials: C
authors.lastname: Cirami
authors.forename: A M
authors.initials: AM
authors.lastname: Bianchi
authors.forename: P
authors.initials: P
authors.lastname: Galigani
authors.forename: A
authors.initials: A
authors.lastname: Gadducci
authors.forename: L
authors.initials: L
authors.lastname: Colombi
authors.forename: V
authors.initials: V
authors.lastname: Facchini
authors.forename: R
authors.initials: R
authors.lastname: Palla
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003536:Cystadenocarcinoma / Q000188:drug therapy; D004715:Endometriosis / Q000188:drug therapy; D004798:Enzymes / Q000652:urine*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D007770:L-Lactate Dehydrogenase / Q000652:urine; D008875:Middle Aged; D009113:Muramidase / Q000652:urine; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012964:Sodium / Q000652:urine*; D005723:gamma-Glutamyltransferase / Q000652:urine
chemical_list: D004798:Enzymes; D012964:Sodium; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D009113:Muramidase; D002945:Cisplatin
vernacular_title: Nefrotossicità del cisplatino. Effetto sull'escrezione frazionale del sodio e sulla enzimuria.