title: Elevated T cell subpopulations in dental students.
abstract: The absolute numbers of circulating white cells and lymphocyte subpopulations were studied in 25 final-year dental students and compared with a control group of 28 medical students. The total lymphocyte count, total T cell numbers (CD3), T helper/inducer (CD4), and T suppressor/cytotoxic (CD8) numbers were significantly elevated in the dental students as compared with the control group. There was no significant difference in the T helper/inducer to T suppressor/cytotoxic cell ratios or the circulating B cell (CD21) and natural killer cell (CD16) numbers between the study and control groups. Patch testing to mercury and mercuric compounds in both the study and control groups showed no evidence of cutaneous hypersensitivity to mercury. The reason for the observed elevations in T cell subpopulations in dental students is not clear. However, one possible explanation is the dental student's occupational exposure to mercury. Further work is underway to examine this possible relationship and it is suggested that dental personnel take adequate measures to reduce their exposure to mercury until the results of these studies are available.
authors.affiliation: Department of Dermatology, Royal Victoria Hospital, Belfast, Ireland.
authors.forename: D J
authors.initials: DJ
authors.lastname: Eedy
authors.forename: D
authors.initials: D
authors.lastname: Burrows
authors.forename: T
authors.initials: T
authors.lastname: Clifford
authors.forename: A
authors.initials: A
authors.lastname: Fay
mesh_terms: D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte; D001402:B-Lymphocytes; D017252:CD3 Complex; D015496:CD4-Positive T-Lymphocytes; D004781:Environmental Exposure; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007694:Killer Cells, Natural; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008628:Mercury; D011948:Receptors, Antigen, T-Cell; D013335:Students, Dental; D013601:T-Lymphocytes; D050378:T-Lymphocytes, Regulatory
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell; D008628:Mercury