title: Methyl N-(diphenylmethyl)-D,L-tryptophanates: synthesis and benzodiazepine receptor affinity.
abstract: Several Methyl N-(diphenylmethyl)-D,L-tryptophanates were synthetized and the affinity for the central benzodiazepine receptor was measured. Disappointingly, none of the tested compounds showed to be active, even at the high concentration examined.
authors.affiliation: Istituto di Chimica Farmaceutica, Università di Urbino, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Balsamini
authors.forename: E
authors.initials: E
authors.lastname: Duranti
authors.forename: A
authors.initials: A
authors.lastname: Salvatori
authors.forename: G
authors.initials: G
authors.lastname: Spadoni
authors.forename: D
authors.initials: D
authors.lastname: Barone
mesh_terms: D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003975:Diazepam / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*
chemical_list: D011963:Receptors, GABA-A; D001569:Benzodiazepines; D003975:Diazepam