[The first experience of using membranotropic agents in the treatment of the nephrotic syndrome].
To treat children suffering from the nephrotic syndrome, use was made of the membrano-stabilizing agents: zaditen that also has an antiallergic action; dimephosphon, a membrano-stabilizer and immunomodulator. The basis for differentiated use of the drugs was formed by the examination data which enabled one to identify the signs of atopy in children with the hormone-dependent nephrotic syndrome, marked signs of the instability of cellular membranes and different immunologic deviations in children with the hormone-resistant variety of the nephrotic syndrome. During zaditen treatment, the majority of the children with the hormone-resistant nephrotic syndrome manifested an appreciable decrease of the process activity; in some cases, including those with hormone dependence, the treatment with prednisolone could be reduced. In part of the children with the hormone-resistant nephrotic syndrome, the treatment with dimephosphone resulted in a decrease of proteinuria, reduced the instability of cellular membranes, and improved the immunologic parameters.
Ignatova
M S
MS
Moskaleva
E S
ES
Kopyleva
S D
SD
Katysheva
O V
OV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D002648:Child; D002908:Chronic Disease; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy / Q000276:immunology; D007665:Ketotifen / Q000627:therapeutic use*; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000276:immunology; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D009943:Organophosphorus Compounds; C049638:dimephosphon; D011239:Prednisolone; D004205:Cromolyn Sodium; D007665:Ketotifen
Pervyĭ opyt ispol'zovaniia membranotropnykh sredstv v lechenii nefroticheskogo sindroma.