title: The 65-kDa protein from pig heart. A new substrate for Clostridium botulinum ADP-ribosyltransferase (exoenzyme C3).
abstract: In the pig heart sarcolemma, a 65 kDa protein is found to be ADP-ribosylated by Clostridium botulinum ADP-ribosyltransferase (exoenzyme C3). ADP-ribosylation of this protein is regulated by guanyl nucleotides and cytosol factor in a fashion similar to that for other C3 substrates. The new exoenzyme C3 substrate was partially purified. This protein is supposed to be a GTP-binding one.
authors.affiliation: USSR Research Center for Molecular Diagnostics and Therapy, Moscow.
authors.forename: S I
authors.initials: SI
authors.lastname: Hoffenberg
authors.forename: V O
authors.initials: VO
authors.lastname: Rybin
authors.forename: A N
authors.initials: AN
authors.lastname: Efimenko
authors.forename: I N
authors.initials: IN
authors.lastname: Kurochkin
authors.forename: V A
authors.initials: VA
authors.lastname: Tkachuk
mesh_terms: D036002:ADP Ribose Transferases / Q000302:isolation & purification / Q000378:metabolism*; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry* / Q000302:isolation & purification; D001905:Botulinum Toxins; D003014:Clostridium botulinum / Q000737:chemistry / Q000201:enzymology*; D019204:GTP-Binding Proteins / Q000032:analysis; D006352:Heart Ventricles / Q000737:chemistry*; D006868:Hydrolysis; D008970:Molecular Weight; D012508:Sarcolemma / Q000737:chemistry*; D013379:Substrate Specificity; D013552:Swine
chemical_list: D001426:Bacterial Proteins; D036002:ADP Ribose Transferases; C063007:exoenzyme C3, Clostridium botulinum; D001905:Botulinum Toxins; D019204:GTP-Binding Proteins