[Activity of fluoroquinolones studied on a model of suppurative meningoencephalitis caused by Pseudomonas aeruginosa in mice].
Activity of four fluoroquinolones i.e. ofloxacin, enoxacin, pefloxacin and ciprofloxacin was studied on a model of purulent meningoencephalitis caused by intracerebral contamination of mice with P. aeruginosa. 900 mice were involved in the experiment. Ofloxacin and enoxacin were administered per os and pefloxacin and ciprofloxacin were injected subcutaneously. Ofloxacin, pefloxacin and ciprofloxacin were shown to be highly active. Enoxacin showed a low activity. ++Non-fluorinated quinolones were inactive in the model. The activity of the fluoroquinolones was compared with that of gentamicin and dioxidine.
Padeĭskaia
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Mnatsakanian
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D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use; D004195:Disease Models, Animal; D004352:Drug Resistance, Microbial; D015365:Enoxacin / Q000627:therapeutic use; D008590:Meningoencephalitis / Q000188:drug therapy*; D051379:Mice; D015242:Ofloxacin / Q000627:therapeutic use; D015366:Pefloxacin / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects
D000890:Anti-Infective Agents; D015366:Pefloxacin; D015365:Enoxacin; D002939:Ciprofloxacin; D015242:Ofloxacin
Aktivnost' ftorkhinolonov na modeli gnoĭnogo meningoéntsefalita mysheĭ, vyzvannogo Pseudomonas aeruginosa.