Antistreptokinase titres after intravenous streptokinase.
Streptokinase neutralisation titres were measured in a series of 25 patients who received streptokinase for the treatment of acute myocardial infarction. Before treatment, neutralisation titres were low (0.3 X 10(6) neutralisation units or less) in all patients. 3 months after treatment, neutralisation titres in 24 were such that a typical therapeutic dose of 1.5 million units of streptokinase would have been fully neutralised. At 4 1/2-8 1/2 months, 18 of 20 patients had neutralisation titres such that at least 50% of a dose of 1.5 million units of streptokinase would have been neutralised. After 8 months, neutralisation titres ranged from 0.4 to 2.0 million units in 8 patients. A decision to readminister streptokinase within 8 months (and probably up to 1 year) of previous thrombolytic treatment should take account of the neutralising capacity of plasma and the dose should be adjusted accordingly.
Jalihal
S
S
Department of Haematology, University Hospital, Queen's Medical Centre, Nottingham, UK.
Morris
G K
GK
D000906:Antibodies / Q000032:analysis*; D004334:Drug Administration Schedule; D004342:Drug Hypersensitivity / Q000517:prevention & control; D006801:Humans; D007275:Injections, Intravenous; D009203:Myocardial Infarction / Q000188:drug therapy*; D009500:Neutralization Tests; D013300:Streptokinase / Q000008:administration & dosage / Q000276:immunology*
D000906:Antibodies; D013300:Streptokinase