title: Use of ethanol as marker substance to increase patient safety during transurethral prostatic resection. Screening investigation of irrigating fluid absorption in four hospitals and comparison of experienced and inexperienced urologists.
abstract: Of 472 patients at four different hospitals electively undergoing transurethral resection of the prostate (TURP), 192 received Sorbitur as an irrigating fluid with 2% ethanol (w/v) as a marker. Using a breath analyzer (Alcol-meter), the amount of ethanol in expired air was measured regularly during the operation to detect the absorption of irrigating fluid. The ethanol concentration in expired air was plotted against time. The time-ethanol concentration product was used as a measurement of absorbed ethanol marked irrigating fluid. A unit of more than 2.5 was considered to be a major absorption with possible clinical significance. This criterion was fulfilled in 24 percent of the patients. Postoperative serum sodium was shown to decrease more in patients with major absorption than in patients with minor absorption in comparison to preoperative values. The weight of resected tissue and the bleeding per resected gram of tissue was higher in the patients with major absorption, but the resected tissue per operating time was the same in both groups. The experienced urologists had as many patients with absorption as did the inexperienced ones. Ethanol-marked irrigating fluid is a simple, safe, noninvasive, rapid, and cheap method of detecting absorption of irrigating fluid thus increasing patient safety during TURP. This method indicates absorption before clinical signs and symptoms of the TUR syndrome occur. It also provides an easy method for estimating the frequency of absorption of irrigating fluid routinely in clinical work.
authors.affiliation: Department of Urology, University Hospital, Linköping, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Hjertberg
authors.forename: L
authors.initials: L
authors.lastname: Jorfeldt
authors.forename: S
authors.initials: S
authors.lastname: Schelin
mesh_terms: D000042:Absorption; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002983:Clinical Competence; D000431:Ethanol / Q000032:analysis*; D006801:Humans; D007431:Intraoperative Complications / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D011468:Prostatectomy; D007507:Therapeutic Irrigation / Q000009:adverse effects
chemical_list: D015415:Biomarkers; D000431:Ethanol