New antitumor substances, BE-12406A and BE-12406B, produced by a streptomycete. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
New antitumor substances, designated BE-12406A and BE-12406B, were isolated from the culture broth of a streptomycete, strain BA 12406. The active principles were extracted from mycelium by methanol and successively purified by silica gel column chromatography and preparative TLC. BE-12406A and BE-12406B inhibited the growth of vincristine-resistant or doxorubicin-resistant P388 murine leukemia cell lines as well as their parent sensitive cell line. In in vivo experiments, BE-12406A inhibited the growth of S-180 murine ascites tumor.
Kojiri
K
K
Exploratory Research Laboratories, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
Arakawa
H
H
Satoh
F
F
Kawamura
K
K
Okura
A
A
Suda
H
H
Okanishi
M
M
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002845:Chromatography; D004317:Doxorubicin / Q000494:pharmacology; D004351:Drug Resistance; D005285:Fermentation; D007938:Leukemia / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000145:classification / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014750:Vincristine / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; C071794:BE 12406A; C071793:BE 12406B; D014750:Vincristine; D004317:Doxorubicin