Lack of effect of lithium on the renal response to DA1-dopamine receptor stimulation by fenoldopam in normal man.
1. The effect of oral lithium (300 mg) on the renal response to the selective DA1-dopamine receptor agonist fenoldopam was investigated in seven normal men. Lithium had no influence on sodium excretion and renal haemodynamics during fenoldopam infusion. The fenoldopam-induced rise in PRA was enhanced in the presence of lithium. We conclude that a previously described interaction between lithium and the dopamine agonist gludopa is not mediated by DA1-dopamine receptors or is confined to higher doses of lithium.
Girbes
A R
AR
Department of Medicine, State University Hospital Groningen, The Netherlands.
Smit
A J
AJ
Meijer
S
S
Reitsma
W D
WD
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000328:Adult; D000450:Aldosterone / Q000097:blood; D015259:Dopamine Agents / Q000494:pharmacology*; D004573:Electrolytes / Q000652:urine; D005260:Female; D018818:Fenoldopam; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects*; D012083:Renin / Q000097:blood
D015259:Dopamine Agents; D004573:Electrolytes; D011954:Receptors, Dopamine; D000450:Aldosterone; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D008094:Lithium; D012083:Renin; D018818:Fenoldopam