The therapeutic role of octreotide in the management of surgical disorders.
The long-acting somatostatin analogue, octreotide, has recently been made available for clinical use in the United States. This novel synthetic peptide possesses a broad spectrum of physiologic actions primarily involving the inhibition of a variety of gastrointestinal and endocrine functions. Such actions have been utilized in the management of a variety of surgical disorders. Current understanding of the indications and efficacy of this agent in the treatment of surgical disease is reviewed.
Hurst
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Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510.
Modlin
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D000595:Amino Acid Sequence; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D006801:Humans; D008969:Molecular Sequence Data; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*; D015282:Octreotide / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D010182:Pancreatic Diseases / Q000188:drug therapy*
D015282:Octreotide