Evidence for long-term reduction of noradrenaline release after kindling in the rat hippocampus.
The in vivo microdialysis technique was used to monitor steady-state noradrenaline release in the rat hippocampus after hippocampal kindling. At 8 weeks after the last seizure, the noradrenaline release was reduced by 62% in the stimulated hippocampus in kindled animals as compared to non-kindled rats. The reduction was not due to the repeated handling of the animals as assessed in a separate experiment. The results suggest a decrease of inhibitory noradrenergic influence at the primary kindling site, which could play a role in kindling epileptogenesis.
Bengzon
J
J
Department of Medical Cell Research, University of Lund, Sweden.
Kalén
P
P
Lindvall
O
O
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D003956:Dialysis; D006234:Handling, Psychological; D006624:Hippocampus / Q000378:metabolism* / Q000502:physiology; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
D009638:Norepinephrine