title: Further insight into the stereoselective interaction between warfarin and cimetidine in man.
abstract: The urinary profile of R- and S-warfarin, following administration of a single (25 mg) oral dose of racemic warfarin, alone or on day 4 of a 9-day chronic administration of cimetidine (800 mg once daily), was investigated in eight healthy male volunteers. Based on estimated apparent formation clearance values, cimetidine inhibited significantly only the formation of R-6-hydroxywarfarin and R-7-hydroxywarfarin.
authors.affiliation: Department of Pharmacy, Aristotle University of Thessaloniki, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Niopas
authors.forename: S
authors.initials: S
authors.lastname: Toon
authors.forename: M
authors.initials: M
authors.lastname: Rowland
mesh_terms: D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D006900:Hydroxylation; D008297:Male; D013237:Stereoisomerism; D014859:Warfarin / Q000378:metabolism*
chemical_list: D014859:Warfarin; D002927:Cimetidine