title: Glutathione-S-transferase-mediated methylthio displacement and turnover in the metabolism of pentachlorothioanisole by rats.
abstract: 1. The metabolism of pentachlorothioanisole to bis-(methylthio)tetrachlorobenzene was shown to involve turnover of about 50% of the original methylthio group. 2. Metabolites of the displaced methylthio group were methanesulphinic acid and sulphate in the urine, carbon dioxide in the expired air, and unidentified sulphur-containing compounds in the bile.
authors.affiliation: Department of Biochemistry, North Dakota State University, Fargo 58105.
authors.forename: D J
authors.initials: DJ
authors.lastname: Mulford
authors.forename: J E
authors.initials: JE
authors.lastname: Bakke
authors.forename: V J
authors.initials: VJ
authors.lastname: Feil
mesh_terms: D000818:Animals; D001646:Bile / Q000737:chemistry; D001711:Biotransformation; D002247:Carbon Isotopes; D002250:Carbon Radioisotopes; D002722:Chlorobenzenes / Q000493:pharmacokinetics*; D005982:Glutathione Transferase / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013462:Sulfur Radioisotopes
chemical_list: D002247:Carbon Isotopes; D002250:Carbon Radioisotopes; D002722:Chlorobenzenes; D013462:Sulfur Radioisotopes; C031281:pentachloromethylthiobenzene; D005982:Glutathione Transferase