Study of the possible interaction between fentanyl and propofol using a computer-controlled infusion of propofol.
A computer-controlled infusion of propofol designed to achieve a target blood concentration of propofol 3 microgram ml-1 was used to investigate the possibility of an interaction between propofol and fentanyl in 32 patients undergoing body surface surgery. In 16 patients who were not receiving a neuromuscular blocker during maintenance anaesthesia with 67% nitrous oxide, there were no significant differences in blood concentrations of propofol between eight patients who received fentanyl 5 micrograms kg-1 before induction of anaesthesia, and eight patients who did not. In a further 16 patients who received vecuronium during maintenance anaesthesia with 67% nitrous oxide, there were no significant differences in blood propofol concentrations between eight patients who received fentanyl 5 micrograms kg-1 before induction of anaesthesia, and eight patients who did not. Fentanyl administered i.v. immediately before a computer-controlled infusion of propofol resulted in more satisfactory anaesthetic conditions than when fentanyl was not used, but did not significantly prolong the recovery time.
Dixon
J
J
Sir Humphry Davy Department of Anaesthesia, University of Bristol, Bristol Royal Infirmary.
Roberts
F L
FL
Tackley
R M
RM
Lewis
G T
GT
Connell
H
H
Prys-Roberts
C
C
D000328:Adult; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D004347:Drug Interactions; D005283:Fentanyl / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D008838:Microcomputers; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012121:Respiration, Artificial; D014673:Vecuronium Bromide
D014673:Vecuronium Bromide; D005283:Fentanyl; D015742:Propofol