title: Albumin--vitamin D-binding protein haplotypes in Asian-Pacific populations.
abstract: We have determined the various haplotypic combinations between alleles as well as restriction fragment length polymorphisms of two linked genetic markers, albumin and vitamin D-binding protein or group-specific component, in a number of Asian-Pacific populations. Using the partial maximum likelihood method, we constructed a phylogenetic network from the haplotype frequencies to assess relationships among the populations sampled. No systematic linkage disequilibrium was detected between most of the combinations, suggesting a lack of operation of any selection pressure at the two loci. The phylogenetic analysis confirmed the known interrelationships among various populations in the Asian-Pacific region. The Australian aborigines clustered closely with the non-Austronesian-speaking highlanders from Papua New Guinea, as expected. Similarly, the Austronesian-speaking Polynesians, Micronesians, and the Southeast Asians branched off together as a separate group. The position of the Austronesian-speaking Tolais from New Britain with respect to other populations from the Southwest Pacific was anomalous. The Tolais revealed a strong affinity with the Australian aborigines, which is inexplicable. The populations from China formed a tight cluster with other populations from the Asian-Pacific region. Genetic interrelationships of these populations with the white Australians were remote, which is in accordance with the known affinities of various human racial groups.
authors.affiliation: John Curtin School of Medical Research, Australian National University, Canberra.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Easteal
authors.forename: P G
authors.initials: PG
authors.lastname: Board
authors.forename: K M
authors.initials: KM
authors.lastname: Summers
authors.forename: K K
authors.initials: KK
authors.lastname: Bhatia
authors.forename: R L
authors.initials: RL
authors.lastname: Kirk
mesh_terms: D000483:Alleles; D001208:Asia; D004247:DNA / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D010139:Pacific Islands; D010802:Phylogeny; D012150:Polymorphism, Restriction Fragment Length; D012709:Serum Albumin / Q000235:genetics*; D014809:Vitamin D-Binding Protein / Q000235:genetics*
chemical_list: D012709:Serum Albumin; D014809:Vitamin D-Binding Protein; D004247:DNA