title: Chronic intrathecal baclofen administration in severe spasticity.
abstract: On the basis of previous experimental and clinical studies, 14 patients with severe spasticity due to central or spinal cord damage, resistant to all conservative treatments, were selected after a percutaneous trial period for chronic intrathecal baclofen infusion by programmable pumps. The agent was delivered at C4 in quadriplegic patients or in cases with central spasticity and in the neighbouring areas on the affected segments in paraplegic patients. The daily baclofen dose varied from 25 to 260 micrograms and was infused in a bolus, continuously infused or both combined according to the results during the trial period. After a mean follow-up period of 11 months, constant decrease of rigidity, absence of spasms, improvement of bladder function, cramping pain remission, and moderate improvement in walking capacity and transfer activities were usually observed. Neither complications nor side effects were noted.
authors.affiliation: Department of Neurosurgery, University of Salamanca, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Broseta
authors.forename: G
authors.initials: G
authors.lastname: García-March
authors.forename: M J
authors.initials: MJ
authors.lastname: Sánchez-Ledesma
authors.forename: J
authors.initials: J
authors.lastname: Anaya
authors.forename: I
authors.initials: I
authors.lastname: Silva
mesh_terms: D000293:Adolescent; D000328:Adult; D001418:Baclofen / Q000008:administration & dosage*; D001925:Brain Damage, Chronic / Q000188:drug therapy; D002547:Cerebral Palsy / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy*; D009460:Neurologic Examination; D011963:Receptors, GABA-A / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*; D013119:Spinal Cord Injuries / Q000188:drug therapy
chemical_list: D011963:Receptors, GABA-A; D001418:Baclofen