Superoxide production by broncho-alveolar cells is diminished in parainfluenza-3 virus treated guinea pigs.
Guinea pig airways isolated 4, 8 and 16 days (but not 2 days) after intra-tracheal inoculation with parainfluenza-3 virus In Vivo respond hyperreactive to contractile stimuli. In the present study it is shown that the virus-induced airway hyperresponsiveness is associated with a decreased Superoxide production by broncho-alveolar cells after additional stimulation with parainfluenza-3 virus.
Folkerts
G
G
Dept. of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.
van Esch
B
B
Janssen
M
M
Nijkamp
F P
FP
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism* / Q000473:pathology; D006168:Guinea Pigs; D008297:Male; D010224:Parainfluenza Virus 3, Human / Q000502:physiology*; D018184:Paramyxoviridae Infections / Q000378:metabolism* / Q000473:pathology; D013481:Superoxides / Q000378:metabolism*; D013997:Time Factors
D013481:Superoxides