title: [Morphological changes in experimental duodenogastric reflux].
abstract: The model of a total duodenal-gastric reflux was developed in 20 dogs and morphological changes in the stomach were studied. 5 dogs served as control. Histologic changes occurred 3.5 months and 1 year after the operation were characterized by metachromasia, increased mucus formation, proliferation of epithelial and parietal cells, moderate inflammation. Process of the disease had fluctuations. 6 months after the operation 5 dogs were reoperated for the elimination of reflux and were observed for another 6 months. A complete reversibility of all changes was established. Bacteriological studies showed a considerable increase of bacteria population in the stomach and a pH increase. The authors suggest the term 'reflux gastropathy" to replace the term "alkaline reflux-gastritis".
authors.forename: D
authors.initials: D
authors.lastname: Radev
authors.forename: N
authors.initials: N
authors.lastname: Strashimirova
authors.forename: M
authors.initials: M
authors.lastname: Vasileva
authors.forename: V
authors.initials: V
authors.lastname: Dokov
authors.forename: R
authors.initials: R
authors.lastname: Radev
authors.forename: D
authors.initials: D
authors.lastname: Dimov
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004285:Dogs; D004383:Duodenogastric Reflux / Q000378:metabolism / Q000473:pathology*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000382:microbiology; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D010503:Periodic Acid-Schiff Reaction; D009626:Terminology as Topic; D013997:Time Factors
vernacular_title: Morfologicheskie izmeneniia pri duodenogastral'nom reflekse v éksperimente.