Sensory pharmacology.
During the last decade, evidence has been accumulated to demonstrate that a subpopulation of peptide-containing primary afferent neurones serve a dual sensory-efferent function. Considerable effort has been put into the development of pharmacological tools to modulate the release and/or the postjunctional effects of transmitters of primary afferents. This commentary summarizes the different approaches designated to achieve this goal, which, if successful, will lead to true 'sensory pharmacology'.
Donnerer
J
J
Department of Experimental and Clinical Pharmacology, University of Graz, Austria.
Amann
R
R
D000818:Animals; D006801:Humans; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology; D009475:Neurons, Afferent / Q000187:drug effects* / Q000502:physiology; D010525:Peripheral Nerves / Q000187:drug effects / Q000502:physiology