title: Iron modulation of the transferrin gene.
abstract: Introduction of chimeric transferrin-chloramphenicol acetyltransferase genes into transgenic mice provides a model by which modulation of the human transferrin gene may be studied in vivo. Iron injected into this mouse model decreases liver expression of the reporter enzyme in a manner analogous to its effect on plasma transferrin levels.
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007501:Iron / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D008822:Mice, Transgenic; D014168:Transferrin / Q000235:genetics*
chemical_list: D014168:Transferrin; D007501:Iron