The effect of autonomic blockers on heart rate: a comparison between two ethnic groups.
The influence of autonomic blockers on the heart rate of ten Bushmen and eight White volunteers was studied. There were significant differences in heart rate response to atropine alone between the White's and Bushmen. However, after prior beta-adrenoceptor blockade, these differences were no longer significant. It is postulated that a varying pharmacogenetic sensitivity to autonomic blockers may result from inequality of vagal or sympathetic tone.
Meyer
E C
EC
Department of Pharmacology, University of Pretoria, South Africa.
Sommers
D K
DK
Schoeman
H S
HS
Avenant
J C
JC
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000810:Angola; D001285:Atropine / Q000494:pharmacology; D001337:Autonomic Agents / Q000494:pharmacology*; D044383:Black People; D004562:Electrocardiography; D005006:Ethnicity; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D016037:Single-Blind Method; D013019:South Africa; D044465:White People
D000319:Adrenergic beta-Antagonists; D001337:Autonomic Agents; D001285:Atropine