Arachidonic acid and early human growth: is there a relation?
Growth failure is a classical sign of essential fatty acid deficiency. We investigated whether birth weight correlates with the postnatal essential fatty acid status in a group of 29 premature infants. A significant and positive correlation between body weight and plasma triglyceride content of arachidonic acid (20:4n-6) (r = 0.47, p = 0.01) and total omega-6 long-chain polyunsaturated fatty acids (r = 0.49, p less than 0.01) was found. In contrast, there was no positive relation to linoleic acid (18:2n-6) or any omega-3 fatty acid but a significant inverse correlation to alpha-linolenic acid (18:3n-3). We propose that during early life arachidonic acid may have a growth-promoting effect which could be related to its role as an eicosanoid precursor or to its structural function in membrane lipids.
Koletzko
B
B
Kinderklinik, Heinrich-Heine-Universität, Düsseldorf, BRD.
Braun
M
M
D016718:Arachidonic Acid / Q000097:blood*; D001724:Birth Weight; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000097:blood; D006128:Growth / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008041:Linoleic Acids / Q000097:blood; D008055:Lipids / Q000097:blood; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D008041:Linoleic Acids; D008055:Lipids; D014280:Triglycerides; D016718:Arachidonic Acid