Immunoglobulin prophylaxis against milkborne transmission of human T cell leukemia virus type I in rabbits.
Prophylactic effect of human T cell leukemia virus type I (HTLV-I) immune globulin (HTLVIG) against milkborne transmission of HTLV-I was investigated in a rabbit model. Four litters (A-D: 7, 5, 7, and 7 offspring, respectively) born to an HTLV-I-infected rabbit were used. Litters A and D were allowed to grow normally as controls, while litters B and C were given weekly intraperitoneal inoculation of HTLVIG four times until weaning at 4.5 weeks of age. Only 1 (8.3%) of the 12 HTLVIG-inoculated rabbits, compared with 6 (42.9%) of the 14 control rabbits, seroconverted for HTLV-I. Gene amplification detected the presence of HTLV-I proviral sequences in all of the seroconverted but in none of the seronegative rabbits. These results suggest that passive immunization is effective in preventing dam-to-offspring transmission of HTLV-I.
Sawada
T
T
Department of Medicine, Kochi Medical School, Japan.
Iwahara
Y
Y
Ishii
K
K
Taguchi
H
H
Hoshino
H
H
Miyoshi
I
I
D000818:Animals; D015153:Blotting, Western; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015481:HTLV-I Antibodies / Q000096:biosynthesis / Q000627:therapeutic use*; D015490:HTLV-I Infections / Q000517:prevention & control* / Q000635:transmission; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000627:therapeutic use; D007075:Immunoglobulin M / Q000096:biosynthesis; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008892:Milk / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011817:Rabbits
D015481:HTLV-I Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous