[Histopathological study of the esophageal injury induced by high-dose-rate intracavitary irradiation].
The histopathological responses of the rabbit esophagus to high-dose-rate intracavitary irradiation were investigated. After 5, 10 or 15 Gy irradiation using a remote afterloading system, the rabbits were sacrificed on different occasions. The esophagus was excised from each animal and examined histopathologically. Esophageal ulcer was observed 7 to 28 days after the irradiation of the highest dose. Edema and cell infiltration in the lamina propria proceeded mucosal changes like ulcer. Chronic injuries such as mucosal necrosis were seen at 6 months.
Soejima
T
T
Department of Radiology, Kobe University School of Medicine.
Kushima
T
T
Kodama
A
A
Sakaguchi
T
T
Yonezawa
K
K
Hashimura
T
T
Imanaka
K
K
Sako
M
M
Kono
M
M
D000818:Animals; D001918:Brachytherapy / Q000009:adverse effects*; D004947:Esophagus / Q000473:pathology / Q000528:radiation effects*; D011817:Rabbits; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology*