[Serum myoglobin level as a criterion of the effectiveness of adrenergic beta receptor blockaders].
The study was undertaken to examine 20 healthy subjects and 20 patients with Stages I and II hypertensive disease (all being males) under psycho-emotional stress (PES). In terms of relationships between blood pressure values, heart rate, and serum myoglobin (Mb) levels, it was concluded that PES caused various degrees of beta 1- and beta 2-adrenoreceptor activation. Exposing the same patients treated with obsidan to PES revealed more pronounced values and responsiveness of diastolic pressure in a subgroup of patients showing simultaneously a dramatic decrease in Mb levels, which is indicative of alpha-adrenoreceptor activation after beta 2-receptor blockade. It was proposed to apply an index of decreased Mb levels during obsidan therapy as a measure of beta 2-adrenoreceptor blockade.
Belova
E V
EV
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009211:Myoglobin / Q000097:blood*; D011433:Propranolol / Q000627:therapeutic use*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D012016:Reference Values
D009211:Myoglobin; D011943:Receptors, Adrenergic, beta; D011433:Propranolol
Uroven' syvorotochnogo mioglobulina kak kriteriĭ éffektivnosti blokady beta-adrenoretseptorov.