Functional studies of Ca2+ channels from plasmalemma and sarcoplasmic reticulum membranes in muscle cells.
Physiological and biochemical studies (channel characteristics, intracellular Ca2+ determinations and, channel purification, cloning and expression) of the different components involved in the regulation of intercellular Ca2+ have provided new information about their specific role. Recent information favors a major role for plasmalemma Ca2+ channels in E-C coupling of cardiac muscle, while a major role for sarcoplasmic reticulum Ca2+ release channels (ryanodine receptors) is proposed for E-C coupling of skeletal muscle. In smooth muscle, both plasmalemma and sarcoplasmic reticulum (IP3 receptors) Ca2+ channels are involved in E-C coupling. These studies will be comparatively discussed for skeletal, cardiac and smooth muscle cells.
García
J
J
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030.
Fill
M
M
Toro
L
L
Stefani
E
E
D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007425:Intracellular Membranes / Q000502:physiology; D009132:Muscles / Q000166:cytology / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear; D011978:Receptors, Nicotinic / Q000502:physiology*; D019837:Ryanodine Receptor Calcium Release Channel; D012519:Sarcoplasmic Reticulum / Q000502:physiology
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D011978:Receptors, Nicotinic; D019837:Ryanodine Receptor Calcium Release Channel