title: Resistance of Pasteurella multocida A:3,4 to phagocytosis by turkey macrophages and heterophils.
abstract: A virulent field isolate and 2 vaccine strains of Pasteurella multocida A:3,4 were compared for resistance to phagocytosis by turkey macrophages and heterophils, using in vitro assays. The least virulent vaccine strain (M-9) was phagocytosed to a greater degree than was the field isolate or the other vaccine strain (Clemson University). All 3 bacteria differed significantly from each other in the amount of capsular material present as measured by polycationic ferritin labeling and electron microscopy. Removal of the capsule with hyaluronidase resulted in a significant increase in phagocytosis of the field isolate.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602.
authors.forename: B G
authors.initials: BG
authors.lastname: Harmon
authors.forename: J R
authors.initials: JR
authors.lastname: Glisson
authors.forename: K S
authors.initials: KS
authors.lastname: Latimer
authors.forename: W L
authors.initials: WL
authors.lastname: Steffens
authors.forename: J C
authors.initials: JC
authors.lastname: Nunnally
mesh_terms: D000818:Animals; D006098:Granulocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008854:Microscopy, Electron; D009895:Opsonin Proteins; D016979:Pasteurella multocida / Q000276:immunology* / Q000472:pathogenicity / Q000648:ultrastructure; D010587:Phagocytosis; D014422:Turkeys; D014774:Virulence
chemical_list: D009895:Opsonin Proteins