Pentobarbital blocks the stress-induced decrease in [3H]Ro 5-4864 binding in rat kidney.
Exposure to environmental stress causes changes in the binding of [3H]Ro 5-4864 to peripheral benzodiazepine receptors (PBRs). The influence of the central nervous system (CNS) in these stress-induced modifications is unclear. The present study examined whether pretreatment with a dose-response regimen of sodium pentobarbital would impact the stress-induced reduction in renal PBR. Administration of either a sedative/ataxic (20 mg/kg) or hypnotic (60 mg/kg) dose of pentobarbital prior to stress blocks the stress-induced decrease of [3H]Ro 5-4864 binding to renal PBR in rat. These findings suggest that higher-order, supraspinal mechanisms play a critical role in marshalling the renal PBR changes in response to stress.
Drugan
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RC
Schrier Research Laboratory, Department of Psychology, Brown University, Providence, RI 02912.
Holmes
P V
PV
Stringer
A P
AP
D000818:Animals; D001570:Benzodiazepinones; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010147:Pain Measurement / Q000379:methods; D010424:Pentobarbital / Q000494:pharmacology*; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D011963:Receptors, GABA-A / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*; D014316:Tritium
D001570:Benzodiazepinones; D011963:Receptors, GABA-A; D014316:Tritium; C028513:4'-chlorodiazepam; D010424:Pentobarbital