title: Night-time nasal ventilation in neuromuscular disease.
abstract: 14 patients, aged 2-28 years, with neuromuscular disorders and symptomatic sleep hypoventilation received night-time intermittent positive-pressure ventilation with a nasal mask. 9 were treated de novo and 5 had previously been maintained on a cuirass or iron lung. Nasal ventilation was very effective in 10 patients but was not tolerated in 4 of the 5 youngest patients. Nasal ventilation was preferable to other methods of ventilation because the system was non-invasive, quiet, portable, and easy to use and because it allowed considerable independence.
authors.affiliation: Department of Paediatrics, Hammersmith Hospital, London.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Heckmatt
authors.forename: L
authors.initials: L
authors.lastname: Loh
authors.forename: V
authors.initials: V
authors.lastname: Dubowitz
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001784:Blood Gas Analysis; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007040:Hypoventilation / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007384:Intermittent Positive-Pressure Breathing / Q000379:methods*; D008297:Male; D009136:Muscular Dystrophies / Q000097:blood / Q000150:complications / Q000503:physiopathology; D009468:Neuromuscular Diseases / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D011175:Positive-Pressure Respiration / Q000379:methods*; D012189:Retrospective Studies; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D014797:Vital Capacity