title: Effect of estrogens and progesterone on human peripheral erythroid burst-forming unit (BFU-E) growth.
abstract: Variations in the number of peripheral burst-forming unit--erythroid (BFU-E) of healthy women were observed during a prolonged period of observation. These differences were related to different phases of the menstrual cycle. A peak in the number of BFU-E occurred on day 14 of the cycle corresponding to the serum 17-beta-estradiol peak. The effect of estrogens and progesterone on the in vitro growth of peripheral BFU-E of healthy women was assayed. Estrogens demonstrated a stimulatory and progesterone an inhibitory effect in total lymphomonocyte cultures, whereas neither hormone had an effect in monocyte-depleted cultures. Prostaglandin E1 (PGE1) which is known to be secreted by monocytes, stimulated the in vitro growth of peripheral BFU-E. These data suggest that estrogens and progesterone could have a role in the in vitro growth of peripheral BFU-E, probably mediated by monocytes.
authors.affiliation: Istituto di Scienze Biomediche, Università di Milano, Monza, Italy.
authors.forename: T M
authors.initials: TM
authors.lastname: De Feo
authors.forename: M D
authors.initials: MD
authors.lastname: Cappellini
authors.forename: G
authors.initials: G
authors.lastname: Fiorelli
mesh_terms: D000328:Adult; D002455:Cell Division / Q000187:drug effects; D003864:Depression, Chemical; D015672:Erythroid Precursor Cells / Q000166:cytology* / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects; D011374:Progesterone / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D013268:Stimulation, Chemical
chemical_list: D004967:Estrogens; D011458:Prostaglandins E; D011374:Progesterone; D004958:Estradiol