Soil adsorption alters kinetics and bioavailability of trichloroethylene in orally exposed female rats.
Soil contamination with dangerous toxic chemicals remains one of the most difficult problems in this era. Bioavailability of a chemical absorbed through gastrointestinal tract exposure from contaminated soil may differ from that seen following exposure to the pure chemical. In this study 4.6 microCi of 14C-TCE (trichloroethylene) alone, or adsorbed to clay or sandy soil, was administered to female Sprague-Dawley rats. Maximum plasma levels of radioactivity were highest in the presence of clay soil. However, they were similar for TCE alone and sandy-soil-adsorbed chemical. The half-life (t1/2) of absorption was statistically longer and the half-life of elimination was statistically shorter in the presence of sandy soil compared with TCE alone. There were no differences in the area under the plasma concentration-time curves between groups. Liver and kidney exhibited the highest tissue concentrations of radioactivity in all groups. Urine was the primary route of excretion followed by expired air in the pure- and clay-soil-adsorbed groups. However, equal amounts of the dose were excreted in both urine and expired air of the sandy-soil-adsorbed group with a significant increase of radioactivity in expired air throughout the 72-h study period. Trichloroethanol was the major urinary metabolite of TCE.
Kadry
A M
AM
Pharmacology and Toxicology Department, New Jersey Medical School, UMDNJ, Newark 07103-2714.
Turkall
R M
RM
Skowronski
G A
GA
Abdel-Rahman
M S
MS
D000284:Administration, Oral; D000327:Adsorption; D000818:Animals; D001682:Biological Availability; D002250:Carbon Radioisotopes; D005260:Female; D006207:Half-Life; D007408:Intestinal Absorption; D051381:Rats; D011919:Rats, Inbred Strains; D012989:Soil Pollutants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014241:Trichloroethylene / Q000097:blood / Q000493:pharmacokinetics*
D002250:Carbon Radioisotopes; D012989:Soil Pollutants; D014241:Trichloroethylene