Induction of leukotriene B4 formation by dialyzer membranes.
Interactions between blood and dialysis membranes lead to activation of the 5-lipoxygenase pathway of the arachiodonic acid metabolism during hemodialysis. Newly generated leukotriene B4 (LTB4) may contribute to the multifaceted granulocyte abnormalities of uremic patients.
Schiffl
H
H
Medizinische Klinik Innenstadt, Universität München, FRG.
Strasser
T
T
D000368:Aged; D002482:Cellulose / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007688:Kidneys, Artificial; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology*; D007975:Leukotriene B4 / Q000096:biosynthesis / Q000097:blood*; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers; D006435:Renal Dialysis; D013450:Sulfones; D013997:Time Factors
D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D007975:Leukotriene B4; C017662:polysulfone P 1700; D002482:Cellulose; C009865:cuprammonium cellulose