Hyaluronic acid in end-stage renal failure treated by haemodialysis: clinical correlates and implications.
Serum hyaluronic acid was measured in 176 adults and 15 children receiving regular dialysis therapy. Hyaluronic acid was elevated to greater than 80 micrograms/l in more than 90%, with median value 182 micrograms/l (range 39-898 micrograms/l). Concentrations did not correlate with serum creatinine, but showed a significant correlation with duration of dialysis and serum beta 2-microglobulin. Values greater than 400 micrograms/l were frequent in patients whose clinical condition deteriorated, but in others, hyaluronic acid remained stable over 4-15 months. Serum hyaluronic acid is mainly in a high-molecular-weight form, which in the presence of normal hepatic function suggests that there is a metabolic disorder involving connective tissue and/or vascular endothelium that increases with progressive loss of renal function. Hyaluronic acid may also be a biochemical marker of patients whose condition deteriorates despite renal replacement therapy.
Turney
J H
JH
Department of Renal Medicine, General Infirmary, Leeds, UK.
Davison
A M
AM
Forbes
M A
MA
Cooper
E H
EH
D000328:Adult; D002648:Child; D002850:Chromatography, Gel; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood* / Q000737:chemistry; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D016030:Kidney Transplantation; D008970:Molecular Weight; D012016:Reference Values; D006435:Renal Dialysis; D016019:Survival Analysis; D001613:beta 2-Microglobulin / Q000032:analysis
D001613:beta 2-Microglobulin; D006820:Hyaluronic Acid