Cardiac complications observed in elderly patients following 2'-deoxycoformycin therapy.
Deoxycoformycin (dCF) is an investigational nucleoside with significant activity in hairy cell leukemia, cutaneous T-cell lymphoma, and chronic lymphocytic leukemia. During a 4-year period, 11 patients have experienced cardiac events as a complication of dCF therapy under NCI sponsorship. The cases are presented and recommendations for the administration of dCF to patients with pre-existing heart disease are made.
Grem
J L
JL
Clinical Oncology Program, National Cancer Institute, Bethesda, MD 20892.
King
S A
SA
Chun
H G
HG
Grever
M R
MR
D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002637:Chest Pain / Q000139:chemically induced; D004562:Electrocardiography; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced; D015649:Pentostatin / Q000009:adverse effects* / Q000627:therapeutic use
D015649:Pentostatin