[Studies on the mechanism of ginseng polypeptide induced hypoglycemia].
When ginseng polypeptide (GP) was administered iv or sc to mice or rats, the blood sugar and liver glycogen were decreased. The decrease of blood sugar and liver glycogen induced by GP in rats were inhibited by pretreatments with pentolamine and propranolol, respectively. The results suggest that the effect of GP on glucose metabolism may be related to adrenergic receptors. In addition, GP at doses which cause decreases of blood sugar and glycogen, inhibited LDH activity, and consequently produced decrease of lactic acid and increase of pyruvic acid. GP was also found to stimulate SDH and CCO activities (which are respiratory enzymes in the electron transport chain), consequently promote aerobic oxidation course.
Wang
B X
BX
Department of Pharmacology, Academy of Traditional Chinese Medicine, Changchun.
Yang
M
M
Jin
Y L
YL
Liu
P
P
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D003576:Electron Transport Complex IV / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D051379:Mice; D005894:Panax; D010455:Peptides / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D010946:Plants, Medicinal; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D008112:Liver Glycogen; D010455:Peptides; D011433:Propranolol; D000242:Cyclic AMP; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D010646:Phentolamine