Esters of 7-(diphenylmethylene)bicyclo[2.2.1]heptan-2-endo-ol with antiarrhythmic and other activities.
The synthesis of esters derived from 7-(diphenylmethylene)bicyclo[2.2.1]heptan-2-endo-ol, obtained by LiAlH4 reduction of 7-(diphenylmethylene)bicyclo[2.2.1]heptan-2-one, is described. Some of these esters showed an appreciable antiarrhythmic activity in rats, as well as moderate hypotensive and local anesthetic activities in rats and mice, respectively.
Longobardi
M
M
Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.
Bargagna
A
A
Mariani
E
E
Schenone
P
P
Russo
S
S
De Paola
C
C
Stella
L
L
Donnoli
D
D
Falzarano
C
C
Marmo
E
E
D000157:Aconitine / Q000494:pharmacology; D000758:Anesthesia; D000779:Anesthetics, Local / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D004952:Esters; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009636:Norbornanes / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013055:Spectrophotometry, Infrared
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D004952:Esters; D009636:Norbornanes; C071415:7-(diphenylmethylene)bicyclo(2.2.1)heptan-2-ol; D000157:Aconitine