title: Effects of neurotropic agents with a selectivity for alpha-adrenoceptors on nitrile-induced dyskinetic syndrome in mice.
abstract: Allylnitrile, crotononitrile and 2-pentenenitrile induce this behavioral syndrome, which includes persistent random circling, head twitching and backward running. The effects of neurotropic agents, with a selectivity for the alpha 1 or alpha 2 adrenoceptor, were examined on the nitrile-induced behavioral abnormalities. The alpha 1 agonist phenylephrine, the alpha 2 agonist clonidine and the alpha 1 antagonist prazosin, inhibited the behavioral syndrome induced by each nitrile, while the alpha 2 antagonist yohimbine had no effect. These results suggest that the noradrenergic system may be involved in the manifestation of the syndrome. Furthermore, a tonic noradrenergic influence on subcortical systems may be required for the syndrome to occur.
authors.affiliation: Department of Hygiene, School of Medicine, Kanazawa University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tanii
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D003000:Clonidine / Q000494:pharmacology / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D051379:Mice; D009570:Nitriles / Q000633:toxicity*; D010656:Phenylephrine / Q000494:pharmacology / Q000627:therapeutic use; D011224:Prazosin / Q000494:pharmacology / Q000627:therapeutic use; D015016:Yohimbine / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D009570:Nitriles; D010656:Phenylephrine; D015016:Yohimbine; D003000:Clonidine; D011224:Prazosin