[Biochemical mechanisms of compensation for unilateral motor disorders of central genesis and their connection with the immune system].
Unilateral impairments of brain led to appearance of posture asymmetry factors (PAF) in central nervous system, which caused asymmetric function of spinal centers and were responsible for asymmetry of limb muscular tension. During compensation symmetrization of muscular tension was followed by inactivation of PAF using developed in central nervous system antifactors which formed complexes with PAF. These factors of inactivation proved to be thermolabile proteins partially involving IgG. Administration of immunomodulator "Gradex B" into postoperation animals stimulated distinctly restoration of arbitrary movements in impaired limbs. The data obtained suggest that immune system is of importance in control of endogenous substances activity, which are produced in central nervous system; a novel procedure was studied for correction of locomotory impairments of central genesis.
Danilovskiĭ
M A
MA
Loseva
I V
IV
Krasil'nikova
I V
IV
Sviridov
B N
BN
D000818:Animals; D007839:Functional Laterality; D007107:Immune System / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008970:Molecular Weight; D009069:Movement Disorders / Q000209:etiology*; D009479:Neuropeptides / Q000037:antagonists & inhibitors / Q000097:blood / Q000134:cerebrospinal fluid; D014020:Tissue Extracts / Q000378:metabolism
D009479:Neuropeptides; D014020:Tissue Extracts; C057855:postural asymmetry factor
Biokhimicheskie mekhanizmy kompensatsii odnostoronnikh dvigatel'nykh rasstrostv tsentral'nogo geneza i ikh sviaz' s immunnoĭ sistemoĭ.