title: Hepatic, cutaneous and hematologic manifestations in juvenile chronic arthritis.
abstract: Two patients suffering from systemic onset juvenile chronic arthritis (JCA) with a polyarticular course developed an acute illness shortly after commencing a new second line drug (gold and penicillamine). The clinical picture consisted of fever, rash, lymphadenopathy and hepatomegaly with elevated liver enzymes and hematological changes. The possible relationship of the disease to second line drugs is discussed.
authors.affiliation: Pediatric Day Care, Kaplan Hospital, Rehovot, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Barash
authors.forename: M
authors.initials: M
authors.lastname: Cooper
authors.forename: Z
authors.initials: Z
authors.lastname: Tauber
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000150:complications* / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D005260:Female; D006046:Gold / Q000009:adverse effects / Q000627:therapeutic use; D006402:Hematologic Diseases / Q000139:chemically induced*; D006801:Humans; D010396:Penicillamine / Q000009:adverse effects / Q000627:therapeutic use; D012871:Skin Diseases / Q000139:chemically induced*
chemical_list: D006046:Gold; D010396:Penicillamine