[The nuclear DNA content and cellular mitotic regimen in the diagnosis of the radiation pathomorphosis of tumors].
Histological material from 26 patients with laryngeal carcinoma was studied after surgery, photon and remote neutron-photon irradiation. The number of telophases in dividing tumor cells after the mixed irradiation was 1.5-3 times lower as compared to the surgical treatment. This correlated with a significant decrease of the number of cells with high ploidy. It is suggested that the damage to cell cycle occurred after the spin formation, that the parameters studied are sensitive morphological criteria for the diagnosis and prognosis of the tumor cell fate.
Modiaev
V P
VP
Zobnina
M N
MN
Dikovich
M F
MF
D002467:Cell Nucleus / Q000528:radiation effects*; D003131:Combined Modality Therapy; D003592:Cytophotometry; D004273:DNA, Neoplasm / Q000032:analysis / Q000528:radiation effects*; D005214:Fast Neutrons; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000648:ultrastructure*; D008938:Mitosis / Q000528:radiation effects*; D011300:Preoperative Care; D011827:Radiation; D011879:Radiotherapy Dosage
D004273:DNA, Neoplasm
Soderzhanie DNK iader i mitoticheskiĭ rezhim kletok v diagnostike luchevogo patomorfoza opukholeĭ.