Preliminary report: imaging of Kaposi sarcoma and lymphoma in AIDS with indium-111-labelled liposomes.
Kaposi sarcoma and malignant lymphoma were successfully imaged with high purity liposomes containing indium-111 in two patients with AIDS. Gamma camera images of the patient with Kaposi sarcoma showed four discrete lesions along the left foot and calf with no foci along the right foot, and no uptake into clinically enlarged but non-neoplastic lymph nodes. The spread of the Kaposi sarcoma was proximal along the leg. The neoplastic cervical lymph nodes in the second patient who had large-cell diffuse intermediate grade lymphoma were also imaged successfully. Since Kaposi sarcoma and lymphoma frequently involve occult sites, liposome imaging may prove useful in the diagnosis and management of these diseases.
Presant
C A
CA
Wilshire Oncology Medical Group, Los Angeles Oncologic Institute, Los Angeles, California 91790.
Blayney
D
D
Proffitt
R T
RT
Turner
A F
AF
Williams
L E
LE
Nadel
H I
HI
Kennedy
P
P
Wiseman
C
C
Gala
K
K
Crossley
R J
RJ
D000163:Acquired Immunodeficiency Syndrome; D000368:Aged; D005534:Foot Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D007205:Indium Radioisotopes; D007866:Leg / Q000000981:diagnostic imaging*; D008081:Liposomes; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008223:Lymphoma / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009333:Neck; D011877:Radionuclide Imaging; D012514:Sarcoma, Kaposi / Q000000981:diagnostic imaging*
D007205:Indium Radioisotopes; D008081:Liposomes