Effects of oxybutynin, terodiline, and nifedipine on the cystometrogram in conscious rats with infravesical outflow obstruction.
The effects of i.v. administration of different drugs utilized in the therapy of detrusor instability have been studied in conscious catheterized female rats with infravesical outflow obstruction induced by partial urethral ligature, in comparison to normal animals. The effects of oxybutynin (1 mg/kg), terodiline (10 mg/kg), and nifedipine (1 mg/kg), were evaluated with regard to bladder capacity (BVC) and micturition pressure (MP) both in normal and obstructed rats. The effects on micturition and residual volume, as well as on spontaneous contractile activity representative of bladder instability, were also observed in obstructed rats. In normal animals, terodiline and oxybutynin induced a significant decrease in micturition pressure without changes in BVC. In obstructed rats, these drugs administered at the same doses did not induce any significant change in all the observed parameters. Nifedipine that in normal rats also reduced the MP, in obstructed animals induced an inhibition of bladder instability (about 50%) with no effects on the other cystometrographic parameters.
Guarneri
L
L
Pharmacology Department, Research Laboratories, Recordati S.p.A., Milan, Italy.
Ibba
M
M
Angelico
P
P
Testa
R
R
D000818:Animals; D002082:Butylamines / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D007275:Injections, Intravenous; D008333:Mandelic Acids / Q000008:administration & dosage / Q000494:pharmacology; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014524:Urethral Obstruction / Q000188:drug therapy / Q000503:physiopathology*; D001743:Urinary Bladder / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D014554:Urination / Q000187:drug effects
D002082:Butylamines; D008333:Mandelic Acids; C010637:terodiline; D009543:Nifedipine; C005419:oxybutynin