N,N-diallylated analogs of dynorphin A-(1-13) as potent antagonists for the endogenous peptide and selective kappa opioid analgesics.
Lemaire
S
S
Department of Pharmacology, Faculty of Health Sciences, University of Ottawa, Ontario.
Parent
P
P
Lapierre
C
C
Michelot
R
R
D000700:Analgesics; D000818:Animals; D004399:Dynorphins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009292:Narcotic Antagonists; D010446:Peptide Fragments / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects*; D017473:Receptors, Opioid, kappa; D013329:Structure-Activity Relationship; D014649:Vas Deferens / Q000187:drug effects
D000700:Analgesics; D009292:Narcotic Antagonists; D010446:Peptide Fragments; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; C026843:dynorphin (1-13); D004399:Dynorphins