Neurohypophysial peptides selectively depressed high voltage-activated Ca-current in snail neurons.
It was found that neurohypophysial peptides oxytocin and Lys-vasopressin selectively decreased the high voltage-activated component of the inward Ca-current in voltage-clamped Helix pomatia identified neurons in a dose- and time-dependent manner. This effect was unaffected or further enhanced applying phosphodiesterases inhibitors. It is suggested that suppression of high voltage-activated current was due to the activation of the adenylate cyclase system, likely protein kinase A.
Osipenko
O N
ON
Department of General Physiology of the Nervous System, A.A. Bogomoletz Institute, Academy of Sciences of the Ukrainian S.S.R., Kiev.
Kiss
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T
D000818:Animals; D001464:Barium / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D005724:Ganglia / Q000502:physiology; D006372:Helix, Snails; D066298:In Vitro Techniques; D008236:Lypressin / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010121:Oxytocin / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology
D015220:Calcium Channels; D010726:Phosphodiesterase Inhibitors; D014970:Xanthines; D001464:Barium; D002110:Caffeine; D010121:Oxytocin; D008236:Lypressin; C053085:1-methylxanthine; D013806:Theophylline