title: Cardiovascular responses to high-fat and high-carbohydrate meals in young subjects.
abstract: We compared the cardiovascular, glucose, insulin, and catecholamine responses to high-fat (F) and high-carbohydrate (C) meals in healthy young subjects (mean age 23 yr, range 19-39). Cardiac output rose 30 min after C by 32% [95% confidence interval (CI) of the increase +0.32 to +1.64 l/min] and after F by 22% [95% CI +0.30 to +1.96 l/min; P = 0.03, analysis of variance (ANOVA)]. Superior mesenteric artery blood flow rose by 87% 15 min after C (95% CI +119 to +258 ml/min) and by 122% (95% CI +138 to +392 ml/min) 45 min after F, with significantly different patterns of response (interaction effect P less than 0.05, ANOVA). Calf blood flow fell and remained low for 60 min after F but only fell 15 min after C, with a return to fasting levels thereafter (interaction effect P less than 0.03, ANOVA). Thirty minutes postprandially the change of calf blood flow from baseline after C was significantly different than after F (95% CI of differences +0.1 to +2.04 ml.100 ml-1.min-1). Glucose, insulin, and norepinephrine levels increased more after C than after F. Thus there are different regional vascular responses to C and F despite similar cardiac output increases.
authors.affiliation: Department of Physiology, University of Nottingham Medical School, United Kingdom.
authors.forename: M B
authors.initials: MB
authors.lastname: Sidery
authors.forename: I A
authors.initials: IA
authors.lastname: Macdonald
authors.forename: A J
authors.initials: AJ
authors.lastname: Cowley
authors.forename: L J
authors.initials: LJ
authors.lastname: Fullwood
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D002302:Cardiac Output / Q000187:drug effects*; D004041:Dietary Fats / Q000494:pharmacology*; D004044:Dietary Proteins / Q000494:pharmacology*; D004435:Eating; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007328:Insulin / Q000097:blood; D007866:Leg / Q000098:blood supply; D009132:Muscles / Q000098:blood supply*; D009638:Norepinephrine / Q000097:blood; D012039:Regional Blood Flow / Q000187:drug effects; D013152:Splanchnic Circulation / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D004044:Dietary Proteins; D007328:Insulin; D009638:Norepinephrine