Evaluation of cyclosporine-A obtained from Tolypocladium sp. for immunosuppressive potential.
Cyclosporine-A obtained from an indigenous isolate of Tolypocladium sp. was evaluated for immunosuppressive potential by skin grafting in rats using the commercially available Sandimmune as reference at 15 and 30 mg/kg/day for a period of 14 days. The Sandimmune treated animal group showed 83 per cent acceptance of skin grafts while the test preparation treated group showed 67-83 per cent acceptance. The degree of nephro- and hepatotoxicity was comparable for both the preparations.
Balaraman
K
K
Vector Control Research Centre, Pondicherry.
Kuppusamy
M
M
George
N
N
Anandkumar
K
K
Sekar
C
C
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D008297:Male; D003904:Mitosporic Fungi / Q000737:chemistry*; D051381:Rats; D016038:Skin Transplantation
D016572:Cyclosporine