Decavanadate acts like an alpha-adrenergic agonist in redistributing protein kinase C activity.
Perfusion of rat livers with polyvanadate, but not metavanadate, was found to increase in plasma membrane and decrease in cytosol protein kinase C activity, similar to that obtained with phenylephrine, an alpha-adrenergic agonist. The effect was prevented by phenoxybenzamine, but not by propranolol implicating alpha-adrenergic receptor activation. Comparison of crystal structures of decavanadate and nonadrenaline revealed the occurrence of a structural feature of O-O-O(N) with distances of 5.5 A and 2.9 A.
Gullapalli
S
S
Department of Biochemistry, Indian Institute of Science, Bangalore.
Kurup
C K
CK
Ramasarma
T
T
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D015394:Molecular Structure; D009638:Norepinephrine; D010477:Perfusion; D010643:Phenoxybenzamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014638:Vanadates / Q000494:pharmacology*
D000316:Adrenergic alpha-Agonists; D010643:Phenoxybenzamine; D010656:Phenylephrine; D014638:Vanadates; D011433:Propranolol; D011493:Protein Kinase C; D009638:Norepinephrine