Nerve growth factor receptor-like immunoreactivity in nerve fibers in the spinal and medullary dorsal horn of the adult monkey and cat: correlation with calcitonin gene-related peptide-like immunoreactivity.
The distribution of nerve growth factor receptor (NGFr)-like immunoreactivity and of calcitonin gene-related peptide (CGRP)-like immunoreactivity was studied in nerve fibers of the spinal and medullary dorsal horn of the monkey and the cat, using double-labelling immunohistochemistry with polyclonal CGRP antiserum and a monoclonal antibody against human NGFr. In both species there was an extensive distribution overlap between NGFr-LI and CGRP-LI. However, lack of NGFr-LI in many CGRP-immunoreactive axons suggests that not all CGRP-positive primary afferent fibers possess NGFr.
Fried
K
K
Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
Risling
M
M
Arvidsson
U
U
Paulie
S
S
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D002415:Cats; D005455:Fluorescent Antibody Technique; D008252:Macaca fascicularis; D008856:Microscopy, Fluorescence; D009412:Nerve Fibers / Q000737:chemistry*; D009414:Nerve Growth Factors; D051381:Rats; D011956:Receptors, Cell Surface / Q000032:analysis*; D017475:Receptors, Nerve Growth Factor; D013116:Spinal Cord / Q000098:blood supply / Q000737:chemistry*
D009414:Nerve Growth Factors; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor; D015740:Calcitonin Gene-Related Peptide