Effect of lymphokines on beta-adrenoceptor stimulation of human PBMC.
The effect of IL-2, IL-3, IL-4 and GM-CSF on beta-adrenoceptor function of human peripheral blood mononuclear cells (PBMC) was studied. After a 2 h pre-incubation period of PBMC with each of the lymphokines (1-100 units/ml), the isoprenaline stimulated cAMP production in these cells was not altered. However, IL-2 and GM-CSF induced a concentration dependent decrease of the beta-adrenoceptor agonist stimulated cAMP production after a 20 h pre-incubation period.
Van Oosterhout
A J
AJ
Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.
Stam
W B
WB
Nijkamp
F P
FP
D000242:Cyclic AMP / Q000378:metabolism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006801:Humans; D007378:Interleukins / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008222:Lymphokines / Q000494:pharmacology*; D009000:Monocytes / Q000378:metabolism / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*
D007378:Interleukins; D008222:Lymphokines; D011943:Receptors, Adrenergic, beta; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D000242:Cyclic AMP; D007545:Isoproterenol