Salvage of distal flap necrosis by topical superoxide dismutase.
Significance of the reactive oxygen species in distal flap necrosis and the efficacy of superoxide dismutase (SOD) in salvaging necrosis have become indicated in recent studies. To enhance the therapeutic effect of SOD, topical application was designed. Water-soluble ointment containing 1% SOD was prepared, and three experiments were made to study the effect of topical SOD in improving flap survival. Simple application of SOD ointment to the upper surface of the flap had no effect, whereas its application to the under surface or occlusive dressing was effective. These effects were corroborated by assay of tissue SOD activity.
Suzuki
S
S
Department of Plastic Surgery, Faculty of Medicine, Kyoto University, Japan.
Matsushita
Y
Y
Isshiki
N
N
Hamanaka
H
H
Miyachi
Y
Y
D000287:Administration, Topical; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D006085:Graft Survival / Q000187:drug effects; D007249:Inflammation; D008297:Male; D009336:Necrosis; D011183:Postoperative Complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013524:Surgical Flaps / Q000009:adverse effects*
D005609:Free Radicals; D013482:Superoxide Dismutase