Reversal of mydriasis by dapiprazole.
The effect of topical dapiprazole, an alpha-adrenergic receptor blocker, in reversing mydriasis was studied in 50 subjects who received tropicamide 1% and phenylephrine 2.5%. There was a significant difference in the decrease in pupil size between the eye that received dapiprazole and the control eye. This study suggests that dapiprazole 0.5% eye drops are effective and safe in reversing mydriasis after instillation of tropicamide 1% and phenylephrine 2.5%.
Allinson
R W
RW
Department of Ophthalmology, University of Arizona, Tucson.
Gerber
D S
DS
Bieber
S
S
Hodes
B L
BL
D000293:Adolescent; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010656:Phenylephrine / Q000037:antagonists & inhibitors*; D010879:Piperazines; D011680:Pupil / Q000187:drug effects*; D011725:Pyridines / Q000037:antagonists & inhibitors*; D014230:Triazoles / Q000494:pharmacology*; D014331:Tropicamide / Q000037:antagonists & inhibitors*; D014792:Visual Acuity / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D010879:Piperazines; D011725:Pyridines; D014230:Triazoles; D010656:Phenylephrine; C035289:dapiprazole; D014331:Tropicamide