The Dr hemagglutinin, afimbrial adhesins AFA-I and AFA-III, and F1845 fimbriae of uropathogenic and diarrhea-associated Escherichia coli belong to a family of hemagglutinins with Dr receptor recognition.
The receptor specificities of four Escherichia coli cloned hemagglutinins, AFA-I, AFA-III, F1845 fimbriae, and the Dr hemagglutinin were studied. Evidence is provided that all four hemagglutinins recognize as their receptor the Dr blood group antigen. However, results of experiments using enzyme-treated erythrocytes and monoclonal antibodies indicate that the four adhesins recognize different epitopes on the Dr antigen and thus constitute a family of Dr receptor-recognizing bacterial adhesins. Furthermore, the same results suggest that the Dr antigen itself may be divided into subcomponents on the basis of bacterial adhesins.
Nowicki
B
B
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030.
Labigne
A
A
Moseley
S
S
Hull
R
R
Hull
S
S
Moulds
J
J
D018830:Adhesins, Escherichia coli; D001422:Bacterial Adhesion; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D001665:Binding Sites; D001789:Blood Group Antigens; D003967:Diarrhea / Q000382:microbiology; D004910:Erythrocyte Membrane / Q000378:metabolism; D004926:Escherichia coli / Q000166:cytology / Q000472:pathogenicity*; D006388:Hemagglutinins / Q000378:metabolism*; D006801:Humans; D010447:Peptide Hydrolases / Q000494:pharmacology; D014552:Urinary Tract Infections / Q000382:microbiology
D018830:Adhesins, Escherichia coli; D001425:Bacterial Outer Membrane Proteins; D001789:Blood Group Antigens; D006388:Hemagglutinins; D010447:Peptide Hydrolases