title: Alterations of "sleeping time" in the rat induced by drugs which modulate central monoaminergic systems.
abstract: The effects of adrenoceptor agonists and antagonists have been determined on "sleeping time" in the rat--that is, with the animal immobile and adopting a sleeping posture. Alterations in their gross behaviour patterns were assessed also. The specific alpha 2-adrenoceptor agonists (yohimbine, WY 26393, RX 781094 and RS 21361) decreased sleeping time, as did the beta-adrenoceptor agonist clenbuterol. The specific alpha 2-adrenoceptor agonist clonidine gave a large increase in sleeping time at doses in excess of 25 micrograms kg-1. The same effect was seen with the beta-antagonist propranolol and the specific beta 2-antagonist ICI 118551.
authors.affiliation: Department of Biomedical Science, University, Sheffield.
authors.forename: A
authors.initials: A
authors.lastname: Angel
authors.forename: A B
authors.initials: AB
authors.lastname: Majeed
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology; D008297:Male; D011748:Pyrogallol / Q000494:pharmacology; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D013565:Sympatholytics / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D013565:Sympatholytics; D013566:Sympathomimetics; D011748:Pyrogallol; D002707:Chlordiazepoxide; D000661:Amphetamine