title: Sézary-type cutaneous T-cell leukaemia. Response to Winkelmann regimen.
abstract: A 37-year-old woman presented with an aggressive leukaemic form of small T-cell Sézary syndrome. Despite this unusually malignant variant of the disease, there was a dramatic response to a modified Winkelmann regimen of chlorambucil and prednisolone, and a useful, sustained remission of 7 months. The Winkelmann regimen remains an important and relatively non-toxic chemotherapeutic option for palliation of advanced Sézary syndrome.
authors.affiliation: Department of Dermatology, University Hospital, Nottingham, England.
authors.forename: C C
authors.initials: CC
authors.lastname: Harland
authors.forename: M
authors.initials: M
authors.lastname: Balsitis
authors.forename: L G
authors.initials: LG
authors.lastname: Millard
mesh_terms: D000328:Adult; D002699:Chlorambucil / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015458:Leukemia, T-Cell / Q000188:drug therapy*; D008223:Lymphoma / Q000188:drug therapy; D011701:PUVA Therapy; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011379:Prognosis; D012751:Sezary Syndrome / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D002699:Chlorambucil; D011239:Prednisolone