Respective contributions of neuronal activity and presynaptic mechanisms in the control of the in vivo release of dopamine.
Studies performed in several in vivo and in vitro conditions have demonstrated that the release of dopamine from nerve terminals of the nigrostriatal dopaminergic neurons depends not only on the activity of dopaminergic cells but also on presynaptic regulations by heterologous fibers. The presynaptic facilitation of dopamine release by the cortico-striatal glutamatergic neurons has been particularly investigated. A quisqualate/kainate receptor subtype is involved in the direct (tetrodotoxine-resistant) presynaptic regulation of dopamine release by glutamate. The respective roles of presynaptic events and nerve activity in the control of dopaminergic transmission are discussed.
Chéramy
A
A
Chaire de Neuropharmacologie, INSERM U114, Collège de France, Paris.
Barbeito
L
L
Godeheu
G
G
Desce
J M
JM
Pittaluga
A
A
Galli
T
T
Artaud
F
F
Glowinski
J
J
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism / Q000502:physiology; D018698:Glutamic Acid; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology
D005971:Glutamates; D018377:Neurotransmitter Agents; D018698:Glutamic Acid; D004298:Dopamine