title: Immunohistochemical evaluation of bone marrow lymphoid nodules in chronic myeloproliferative disorders.
abstract: One hundred and seventy bone marrow biopsies from patients with chronic myeloproliferative disorders (CMPDs) were evaluated for the presence of lymphoid nodules (LNs) and were immunostained using a panel of monoclonal antibodies (UCHL1, 4KB5 and L26) recognizing different lymphocyte antigens. LNs were found in 35% of cases of idiopathic thrombocythaemia, 24.6% of myelofibrosis/osteomyelosclerosis, 18.2% of polycythaemia vera 12.1% of chronic myeloid leukaemia and 19.2% of borderline cases. Varying degrees of immunohistochemical positivity for the three antibodies tested were found. LNs were always made up of variable proportions of both T- and B-lymphocytes with a prevalence of T-cells. This latter observation suggests that bone marrow LNs in CMPDs could be an expression of reactivity.
authors.affiliation: Institute of Pathological Anatomy, University of Palermo, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Franco
authors.forename: A M
authors.initials: AM
authors.lastname: Florena
authors.forename: F
authors.initials: F
authors.lastname: Aragona
authors.forename: G
authors.initials: G
authors.lastname: Campesi
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal; D001853:Bone Marrow / Q000473:pathology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000276:immunology / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal