title: Three genes for enzymes of the pyruvate dehydrogenase complex map to human chromosomes 3, 7, and X.
abstract: The genes for three proteins of the pyruvate dehydrogenase (PDH) complex have been assigned to human chromosomes by Southern analysis of a panel of human-rodent somatic cell hybrid DNAs with cDNA probes for these genes. PDH-E1 alpha has been localized on human chromosome 3p13-q23. The assignments of lipoamide dehydrogenase(E3) and PDH-E1 alpha [corrected] to chromosomes 7 and Xp, respectively, have been confirmed. Restrictive-fragment-length polymorphisms have been identified with E3, which will permit further localization of this gene by genetic linkage analysis.
authors.affiliation: National Institutes of Health 20892.
authors.forename: S
authors.initials: S
authors.lastname: Olson
authors.forename: B J
authors.initials: BJ
authors.lastname: Song
authors.forename: T L
authors.initials: TL
authors.lastname: Huh
authors.forename: Y T
authors.initials: YT
authors.lastname: Chi
authors.forename: R L
authors.initials: RL
authors.lastname: Veech
authors.forename: O W
authors.initials: OW
authors.lastname: McBride
mesh_terms: D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D006224:Cricetinae; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D051379:Mice; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D011768:Pyruvate Dehydrogenase Complex / Q000235:genetics*; D014960:X Chromosome
chemical_list: D011768:Pyruvate Dehydrogenase Complex; D004247:DNA