Effects of pentoxifylline on hemodynamics, oxygen transport, and tissue metabolism in experimental, severe hemorrhagic shock.
METHODS
It is hypothesized that pentoxifylline may be beneficial during shock states by improving tissue oxygenation. To test this hypothesis, we examined the effect of pentoxifylline on hemodynamics, oxygen delivery (DO2), and tissue metabolism during severe hemorrhagic shock. We conducted a placebo-controlled, randomized trial using anesthetized, mechanically ventilated dogs in hemorrhagic shock maintained at a mean arterial pressure of 45 to 50 mm Hg. Six animals were treated with a 10-mg/kg bolus of iv pentoxifylline followed by a continuous infusion at 5 mg/kg.hr. The controls consisted of six animals treated with saline.


RESULTS
There were no significant differences between the groups before treatment. During 150 mins of posttreatment, repeated measurements of the control and pentoxifylline groups showed no significant differences in heart rate (HR), cardiac output, systemic and pulmonary vascular resistances, DO2, or blood lactate concentration (repeated-measures analysis of variance).


CONCLUSIONS
In this acute, nonresuscitated, canine hemorrhagic shock model, pentoxifylline did not act as a vasodilator, or have any significant effect on HR, cardiac output, oxygen transport, or lactic acidosis.
Oropello
J M
JM
Department of Surgery, Surgery and Anesthesia, Mount Sinai Medical Center, New York, NY 10029.
Amin
D
D
Klapholtz
A
A
Benjamin
E
E
Fischer
E
E
Jacobs
E
E
Iberti
T J
TJ
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004311:Double-Blind Method; D004353:Drug Evaluation, Preclinical; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D010101:Oxygen Consumption / Q000187:drug effects*; D010431:Pentoxifylline / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology
D007773:Lactates; D019344:Lactic Acid; D010431:Pentoxifylline