Fluconazole failure in the treatment of invasive mycoses.
Fluconazole is a recently licensed antifungal agent that has gained widespread use in the medical community. Despite a lack of controlled trials in invasive fungal infections, this agent is often prescribed because of ease of administration and concern over amphotericin B toxicity. Three cases of systemic fungal infections in which fluconazole use resulted in unambiguous microbiologic and clinical failure are reported.
Evans
T G
TG
Division of Infectious Diseases, University of Utah, Salt Lake City.
Mayer
J
J
Cohen
S
S
Classen
D
D
Carroll
K
K
D000666:Amphotericin B / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy*; D003047:Coccidioidomycosis / Q000188:drug therapy*; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000666:Amphotericin B; D015725:Fluconazole