[Effects of ginseng polysaccharides on reducing blood glucose and liver glycogen].
Ginseng polysaccharides (GH1) 50-200 mg/kg ip or sc reduced blood glucose and liver glycogen of mice. Adrenalectomy did not affect this action. GH1 increased the content of pyruvic acid, but decreased the content of lactic acid by weakening the activity of lactate dehydrogenase. GH1 accelerated oxidative-phosphorylation of carbohydrate since the activities of succinate dehydrogenase (SDH) and cytochrome oxidase (CCO) were obviously stimulated. Besides the promotion of the activity of SDH in human embryonic lung fibroblasts (HELF), GH1 decreased the content of polysaccharides in HELF of the 24th age generation, but increased that of the 40th age generation. On the other hand, GH1 stimulated the release of insulin. It is suggested that the reduction of blood glucose and liver glycogen induced by GH1 be primarily due to the increase of carbohydrate utilization and the decrease of glycogenesis.
Yang
M
M
Academy of Traditional Medicine & Materia Medica of Jilin Province, Changchun, China.
Wang
B X
BX
Jin
Y L
YL
Wang
Y
Y
Cui
Z Y
ZY
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D007004:Hypoglycemic Agents; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D051379:Mice; D005894:Panax; D010946:Plants, Medicinal; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008112:Liver Glycogen; D011134:Polysaccharides; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV