Gestational trophoblastic tumours following initial diagnosis of partial hydatidiform mole.
11 patients registered with an initial diagnosis of partial hydatidiform mole (PHM) subsequently required chemotherapy for a gestational trophoblastic tumour. In a retrospective review by histopathological examination and measurement of DNA ploidy, the diagnosis was confirmed as PHM in 5 cases and revised to complete hydatidiform mole in 4; in 2 cases there was no evidence of a molar pregnancy. 4 of the patients with PHM had no other known pregnancy before the gestational trophoblastic tumour and in 2 of these patients the tumour was diagnosed histologically as choriocarcinoma. Not all patients in whom PHM was diagnosed at referring hospitals proved to have the condition. Although the risk of a patient with PHM requiring chemotherapy for gestational trophoblastic tumour is of the order of 1 in 200, compared with 1 in 12 after a complete mole, there is no justification for excluding a patient from follow-up after the evacuation of a PHM.
Bagshawe
K D
KD
Department of Medical Oncology, Charing Cross and Westminster Medical School, London, UK.
Lawler
S D
SD
Paradinas
F J
FJ
Dent
J
J
Brown
P
P
Boxer
G M
GM
D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000235:genetics / Q000473:pathology*; D002820:Hydatidiform Mole, Invasive / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D008875:Middle Aged; D011003:Ploidies; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000097:blood / Q000188:drug therapy*; D011272:Pregnancy, Multiple / Q000097:blood / Q000235:genetics; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014328:Trophoblastic Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D014594:Uterine Neoplasms / Q000097:blood / Q000235:genetics / Q000473:pathology*
D006063:Chorionic Gonadotropin; D004273:DNA, Neoplasm