Changes in blood leucocyte populations induced by acute maximal and chronic submaximal exercise.
Absolute (x 10(3).mm-3) or relative (%) numbers of blood leucocyte types (monocytes, lymphocytes, neutrophils) and lymphocyte subsets (T11+, T4+, T8+, B1+, and NKH1+) reacting with specific monoclonal antibodies were determined at rest, immediately after maximal exercise on a treadmill, in six controls (C), and in six young cyclists before training (BT) and after 5 months of training (AT). Maximal exercise significantly increased the absolute number (mobilization) of virtually all the types of leucocytes and subsets of lymphocytes in C, BT and AT subjects. In these subjects mobilization of natural killer cells (NKH1+) and cytotoxic/suppressor T lymphocytes (T8+) was greater than mobilization of the other leucocyte types and lymphocyte subsets; however, maximal exercise induced no significant changes in the relative numbers of any leucocyte types and lymphocyte subsets, except in the case of T4+ lymphocytes in At cyclists. Chronic submaximal exercise induced increased mobilization of neutrophils and decreased mobilization of lymphocytes during maximal exercise, except in the case of B lymphocytes (B1+) and NKH1+ cells, and decreases in the absolute and relative number of neutrophils at rest. It remains to be seen how these results can explain the modifications of leucocyte activities noted in vitro after isolated or chronic exercise.
Ferry
A
A
Laboratoire de Physiologie des Adaptations UFR Cochin-Port-Royal, Université Paris V, France.
Picard
F
F
Duvallet
A
A
Weill
B
B
Rieu
M
M
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology / Q000502:physiology*; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D009000:Monocytes / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D010806:Physical Education and Training; D013601:T-Lymphocytes / Q000502:physiology