A rapid visual test for predicting fetal lung maturity.
A rapid bedside test has been devised that enables an untrained observer to predict (p less than 0.001) when amniotic fluid will be greater than or equal to 0.15 at an optical density of 650 nm, lecithin/sphingomyelin ratio will be greater than or equal to 2.0, or when phosphatidylglycerol will be present. By a visual comparison of the turbidity of unspun amniotic fluid against positive (mature) or negative (immature) controls, technicians and resident physicians who had had no special training were able to classify correctly 87.2% (82/94) of unknown amniotic fluid samples. The sensitivity of the new test is 90.8% (58/65); the specificity is 70.3% (23/29). Thus, when more sophisticated methods are not readily available, we believe that this easily performed and accurate test can provide supplemental or preliminary data for patient management. In remote geographic areas our method could serve as the primary source of information about fetal lung maturity.
Sbarra
A J
AJ
Department of Medical Research and Laboratories, St. Margaret's Hospital for Women, Boston, MA 02125.
Chaudhury
A
A
Cetrulo
C L
CL
Mittendorf
R
R
Shakr
C
C
Kennison
R
R
Jones
J
J
Kennedy
J
J
D000653:Amniotic Fluid; D005260:Female; D005325:Fetal Organ Maturity; D006801:Humans; D008168:Lung / Q000196:embryology*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012680:Sensitivity and Specificity