title: [EEG changes and seizures with clozapine medication in schizophrenic adolescents].
abstract: Clozapine is an effective antipsychotic agent with atypical neuroleptic and side effects. The risk of pathological changes in the EEG and of seizures is correlated to the dosage administered. With dosages of 300 mg/day or higher the EEG should be monitored regularly. The neurophysiological effects of this drug, known only in adults up till now, were also found in adolescents suffering from schizophrenia.
authors.affiliation: Klinik Rottmannshöhe, Jugendpsychiatrische Abteilung, Heckscher Klinik München.
authors.forename: H
authors.initials: H
authors.lastname: Braun-Scharm
authors.forename: J
authors.initials: J
authors.lastname: Martinius
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex / Q000187:drug effects* / Q000503:physiopathology; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D003024:Clozapine
vernacular_title: EEG-Veränderungen und Anfälle unter Clozapin-Medikation bei schizophrenen Jugendlichen.