[Sex differences in the accumulation of estrogen receptors in nuclei of liver cells and increase of angiotensinogen concentration in the blood of rats after administration of low doses of synthetic estrogens].
The significance of sex differences in the level of estrogen receptors (ER) in hepatocytes for direct effects of estrogens in male and female rat livers was investigated. 4-5-fold increase in ER level and 20-30%-elevation in plasma angiotensinogen (AG) occurred after a single injection of 0.5 microgram of hexestrol (HE) in female and gonadectomized male rats. In male liver, where the cytosol ER content is two fold lower than that in female rats, nuclear ER level was shown to be very low and unchanged after HE injection, plasma AG also did not change. Injection of 0.5 microgram of ethinylestradiol produced similar effect. Injection of a greater dose of estrogen caused an enhancement in plasma AG level in males. The existence of sex differences in hepatic ER level seems to cause in some conditions different response of metabolic processes in male and female rat liver after estrogenization.
Ignatenko
L L
LL
Mataradze
G D
GD
Buniatian
A F
AF
Rozen
V B
VB
D000808:Angiotensinogen / Q000097:blood*; D000818:Animals; D002369:Castration; D002467:Cell Nucleus / Q000737:chemistry*; D003600:Cytosol / Q000737:chemistry; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D006589:Hexestrol / Q000494:pharmacology; D008099:Liver / Q000737:chemistry*; D008297:Male; D051381:Rats; D011960:Receptors, Estrogen / Q000032:analysis*; D012727:Sex Characteristics
D011960:Receptors, Estrogen; D006589:Hexestrol; D000808:Angiotensinogen; D004997:Ethinyl Estradiol
Polovye razlichiia v nakoplenii éstrogennykh retseptorov v iadrakh kletok pecheni i uvelichenii kontsentratsii angiotenzinogena v plazme krovi krys pri vvedenii niznikh doz sinteticheskikh éstrogenov.