title: Regulatory functions for murine intraepithelial lymphocytes in mucosal responses.
abstract: Our studies have given direct evidence that CD3+, CD4-, CD8+ T cells in the IELs can be separated into at least two subsets that produce IFN-gamma and/or IL-5 and may exhibit Th1- and Th2-type functions in the epithelium and in the underlying lamina propria region. Further, it was also shown that TCR1+ T cells in IELs are capable of producing IFN-gamma and/or IL-5. In addition to production of these cytokines, IELs derived from mice orally primed with TD antigen contain a subset of T cells which possess antigen-specific immunoregulatory function. CD3+, CD4-, CD8+ T cells isolated from IEL of TD antigen-primed mice abrogated systemic unresponsiveness to secondary-type responses including those of the IgA isotype upon adoptive transfer to mice with OT. Our studies further suggested that these CD3+, CD4-, CD8+ IELs use the gamma-delta form of TCR (TCR1) for their immunoregulatory function.
authors.affiliation: Department of Oral Biology, University of Alabama, Birmingham.
authors.forename: H
authors.initials: H
authors.lastname: Kiyono
authors.forename: K
authors.initials: K
authors.lastname: Fujihashi
authors.forename: T
authors.initials: T
authors.lastname: Taguchi
authors.forename: W K
authors.initials: WK
authors.lastname: Aicher
authors.forename: J R
authors.initials: JR
authors.lastname: McGhee
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D016207:Cytokines / Q000096:biosynthesis; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D007070:Immunoglobulin A / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D051379:Mice; D011948:Receptors, Antigen, T-Cell
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D016207:Cytokines; D007070:Immunoglobulin A; D011948:Receptors, Antigen, T-Cell