Biotransformation of the partial beta-agonist doxaminol in dog.
The biotransformation of the positive inotropic compound doxaminol (N-methyl-N-(2-hydroxy-3-phenoxy-propyl)-11-(2-amino-ethyl)-6,11- dihydrodibenz[b,e]oxepine, neutral fumarate; BM 10.188) was examined in bastard shepherd dogs. Metabolic products, formed by oxidative cleavage of various side chain carbon atoms of the molecule, as well as conjugated complexes with glucuronic and sulfuric acid, were isolated from urine and plasma. As main metabolites 2-hydroxy-3-phenoxy-propionic acid and phenoxyacetic acid were formed. By means of 1HNMR and 13C-NMR spectroscopy and various mass spectroscopic methods, the chemical structures of the metabolites were elucidated.
Neidlein
R
R
Pharmaceutical-Chemical Institute, University of Heidelberg, Fed. Rep. of Germany.
Volland
C
C
Strein
K
K
D000318:Adrenergic beta-Agonists / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D002855:Chromatography, Thin Layer; D003990:Dibenzoxepins / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D004285:Dogs; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005965:Glucuronates / Q000097:blood / Q000652:urine; D009682:Magnetic Resonance Spectroscopy; D013431:Sulfates / Q000097:blood / Q000652:urine
D000318:Adrenergic beta-Agonists; D003990:Dibenzoxepins; D005965:Glucuronates; D013431:Sulfates; C034187:doxaminol