[Proliferation of alveolar macrophages in pulmonary sarcoidosis correlates with markers of lymphocyte activity in bronchoalveolar lavage fluid].
The proliferation of alveolar macrophages in 47 patients with pulmonary sarcoidosis was investigated using immune peroxidase stains with the monoclonal antibody Ki-67. In patients suffering from sarcoidosis, a significantly elevated number of Ki-67-positive alveolar macrophages was observed. The number of proliferating alveolar macrophages showed a significant positive correlation both with the number of lymphocytes in the BAL fluid and with the T4/T8 quotient in the BAL fluid of sarcoidosis patients.
Barth
J
J
I. Medizinische Klinik, Christian-Albrechts-Universität, Kiel.
Kreipe
H
H
Kiemle-Kallee
J
J
Radzun
H J
HJ
Petermann
W
W
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D019394:Ki-67 Antigen; D007958:Leukocyte Count; D008171:Lung Diseases / Q000276:immunology*; D008262:Macrophage Activation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D011650:Pulmonary Alveoli / Q000276:immunology*; D012507:Sarcoidosis / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D019394:Ki-67 Antigen
Die Proliferation von Alveolarmakrophagen bei pulmonaler Sarkoidose korreliert mit lymphozytären Aktivitätsmarkern der BAL.