title: [The action of fenoptin on cAMP dynamics in the isolated guinea pig heart during contraction-relaxation].
abstract: The influence of finoptin and Ca2+ concentration decrease on cAMP dynamic during cardiac cycle in guinea pig isolated heart, activated by isadrin (3 x 10(-8) M), has been studied. In isadrin activation of adrenoceptors cAMP concentration increased by 50% during contraction and decreased during relaxation. Hypocalcium solution (0.15 mM) and finoptin decreased cAMP concentration and influenced its dynamic during cardiac cycle.
authors.forename: B I
authors.initials: BI
authors.lastname: Laptev
authors.forename: I B
authors.initials: IB
authors.lastname: Bardamova
authors.forename: S A
authors.initials: SA
authors.lastname: Afanas'ev
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Talaeva
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002317:Cardiovascular Agents / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D002317:Cardiovascular Agents; C046978:phenoptin; D014700:Verapamil; D000242:Cyclic AMP; D002118:Calcium
vernacular_title: Deĭstvie fenoptina na dinamiku tsAMF v izolirovannym serdtse morskoĭ svinki v protsesse ee sokrasheniia--rasslebleniia.