title: [Lambert-Eaton myasthenia syndrome--review with case report].
abstract: The pathogenetic and therapeutic concepts in Lambert-Eaton Myasthenic Syndrome (=LEMS) are changing. The disease has been proved to be an autoimmune reaction to voltage-dependent calcium channels of the presynaptic membrane at the neuromuscular junction. As pointed out in a case report, autonomic dysfunction can be an early sign and symptom of LEMS. The update review of the literature deals with the diagnosis, aetiology and therapy of the often but not exclusively paraneoplastic induced disease.
authors.affiliation: Neurologische Uni-Klinik Kiel.
authors.forename: F
authors.initials: F
authors.lastname: Engler
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000175:diagnosis; D018288:Carcinoma, Small Cell / Q000175:diagnosis*; D019791:Guanidine; D006146:Guanidines / Q000008:administration & dosage; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D006146:Guanidines; D019791:Guanidine
vernacular_title: Das myasthene Syndrom Lambert-Eaton--Ubersicht mit Kasuistik.