[Effect of antibiotics on fecal excretion of various products of microbial metabolism of aromatic amino acids].
The model experiments on intact albino rats and those exposed to lincomycin, ampicillin and rifampicin showed that intragastric administration of the three antibiotics to the laboratory animals in therapeutic doses for 8 days induced statistically significant changes in the fecal excretion of n-cresol, indole and skatole, microbial metabolites of aromatic amino acids in the gastrointestinal tract of a macroorganism. The results are in favour of using biochemical tests for rapid diagnosis of the intestinal microflora response to antimicrobial agents.
Mitrokhin
S D
SD
Sladkova
T V
TV
Vagina
T V
TV
Shenderov
B A
BA
D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism*; D000667:Ampicillin / Q000494:pharmacology*; D000818:Animals; D003408:Cresols / Q000737:chemistry*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*; D008034:Lincomycin / Q000494:pharmacology*; D008297:Male; D019800:Phenol; D010636:Phenols / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D012293:Rifampin / Q000494:pharmacology*; D012862:Skatole / Q000737:chemistry*
D000596:Amino Acids; D003408:Cresols; D010636:Phenols; C032538:4-cresol; D019800:Phenol; D000667:Ampicillin; D012862:Skatole; D008034:Lincomycin; D012293:Rifampin
Vliianie antibiotikov na ékskretsiiu s fekaliiami nekotorykh produktov mikrobnogo metabolizma aromaticheskikh aminokislot.