title: Effects of defective interfering viruses on virus replication and pathogenesis in vitro and in vivo.
abstract: DI viruses and defective viruses generally are widespread in nature. Laboratory studies show that they can sometimes exert powerful disease-modulating effects (either attenuation or intensification of symptoms). Their role in nature remains largely unexplored, despite recent suggestive evidence for their importance in a number of systems.
authors.affiliation: Département de Microbiologie, CMU, Geneva, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Roux
authors.forename: A E
authors.initials: AE
authors.lastname: Simon
authors.forename: J J
authors.initials: JJ
authors.lastname: Holland
mesh_terms: D000818:Animals; D003673:Defective Viruses / Q000502:physiology*; D006801:Humans; D010944:Plants / Q000382:microbiology; D018406:Virus Physiological Phenomena; D014779:Virus Replication; D014780:Viruses / Q000235:genetics / Q000472:pathogenicity