title: Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and 145Sm as a brachytherapy source.
abstract: A technique to produce radiation enhancement during interstitial brain tumor irradiation by using a radiation sensitizer (iododeoxyuridine-IdUrd) and by stimulation of Auger electron cascades through absorption of low-energy photons in iodine is described. Clinical studies using iododeoxyuridine, 192Ir as a brachytherapy source, and external radiation have produced promising results. Substituting 145Sm for 192Ir in this protocol is planned to evaluate the enhanced dose resulting from photon activation therapy.
authors.affiliation: Department of Surgery, Ohio State University, Columbus.
authors.forename: J H
authors.initials: JH
authors.lastname: Goodman
authors.forename: R A
authors.initials: RA
authors.lastname: Gahbauer
authors.forename: C
authors.initials: C
authors.lastname: Kanellitsas
authors.forename: N R
authors.initials: NR
authors.lastname: Clendenon
authors.forename: B H
authors.initials: BH
authors.lastname: Laster
authors.forename: R G
authors.initials: RG
authors.lastname: Fairchild
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D007065:Idoxuridine / Q000008:administration & dosage*; D011838:Radiation-Sensitizing Agents; D011868:Radioisotopes / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D012493:Samarium / Q000627:therapeutic use; D013238:Stereotaxic Techniques
chemical_list: D011838:Radiation-Sensitizing Agents; D011868:Radioisotopes; D012493:Samarium; D007065:Idoxuridine