title: Interaction of cisplatin with other cytotoxics and non-steroidal anti-inflammatory drugs.
abstract: This study investigated a possible interaction between cisplatin, other cytotoxics and non-steroidal anti-inflammatory drugs. Experiments were performed in quadruplicate. Plasma was spiked with cisplatin with or without another cytotoxic or non-steroidal anti-inflammatory drug. The results were analysed by Student's t-test and a p value of less than 0.05 was accepted as statistically significant. No interaction between cisplatin and the other cytotoxics was demonstrated. However, an increase in free cisplatin was noted when mixed with indomethacin (p = 0.019). No interaction with the other non-steroidal anti-inflammatory drugs was demonstrated.
authors.affiliation: Oncology Department, Repatriation General Hospital, Melbourne, Australia.
authors.forename: W
authors.initials: W
authors.lastname: Cosolo
authors.forename: M A
authors.initials: MA
authors.lastname: Schwarz
authors.forename: N
authors.initials: N
authors.lastname: Christophidis
authors.forename: J R
authors.initials: JR
authors.lastname: Zalcberg
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D004347:Drug Interactions; D004351:Drug Resistance; D004355:Drug Stability; D005260:Female; D014644:Genetic Variation / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D002945:Cisplatin