[The systemic and regional changes in the modelling of a massive pulmonary artery embolism].
In anesthetized dogs with natural breathing, embolisation of pulmonary arterial bed increased systolic pressure in the right ventricle of the heart up to 60.0-113.0 mm Hg. Within 6 hrs the pressure far exceeded initial and control parameters in the minor circulation circle. Tachycardia and tachypnea as well as a reduction of the left ventricle contractions and a decrease of arterial pressure occurred. The massive emboli was followed by an obvious hypoxia and an insignificant hypocapnia with no essential shifts in the blood acid-base balance. Subsequent interstitial oedema of pulmonary tissue may be due both to the changes in the lung hemodynamics and to direct damaging of endothelium in the microvessels.
Virganskiĭ
A O
AO
Banin
V V
VV
Klevtsov
V A
VA
Rogulenko
R V
RV
Strupin
I V
IV
Tverskaia
M S
MS
Tikhvinskaia
E I
EI
D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D006328:Cardiac Catheterization; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D008168:Lung / Q000503:physiopathology / Q000648:ultrastructure; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D011655:Pulmonary Embolism / Q000209:etiology / Q000503:physiopathology*; D015656:Respiratory Mechanics / Q000502:physiology; D013997:Time Factors
Sistemnye i regionarnye izmeneniia pri modelirovanii massivnoĭ émbolii legochnoĭ arterii.