[Synthesis and antibacterial as well as antineoplastic activities of 2,4-diamino-5-methyl-6-(N-methyl-substituted benzyl) aminoquinazolines].
This paper reports four methods for the synthesis of 2,4-diamino-5-methyl-6-(N-methyl-substituted benzyl) aminoquinazolines. Six compounds were synthesized and all these compounds showed good anticancer and antibacterial activities. Among them, I5 showed the strongest inhibition against L1210 Leukemia cell and further research has to be done.
Meng
X Y
XY
Shanghai Institute of Pharmaceutical Industry.
Zhang
X P
XP
Chen
X H
XH
Yu
A Z
AZ
D000818:Animals; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D007939:Leukemia L1210 / Q000473:pathology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D011799:Quinazolines