title: Effect of ivermectin delivered from a sustained-release bolus on the productivity of beef cattle in Oregon.
abstract: The effect of ivermectin delivered from a sustained-release bolus (I-SRB) on the weight gain of beef cattle through a grazing season was evaluated using 20 yearling beef steer calves randomly divided into two groups of ten animals each. Calves in the control group each received a placebo bolus, while those in the treatment group each received an I-SRB designed to release 12 mg ivermectin day-1 for approximately 90 days. All animals were weighted and samples of feces were collected from the rectum at monthly intervals, beginning on Day 0, until trial termination (Day 148). Pasture larval counts were also conducted on herbage collected on each sampling date. On Day 119, two control and two treated calves were removed from pasture, housed in isolation for 3 weeks, then necropsied for recovery of gastrointestinal nematodes. Three sets of parasite-naive tracer calves were utilized to evaluate the initial, interim and final levels of pasture contamination by nematode larvae. A fourth set was used to evaluate the level of pasture contamination the following spring. The use of the I-SRB resulted in a greater than 99% reduction in fecal egg counts of trichostrongyles and numbers of gastrointestinal nematodes in the treated principals, as well as an average daily gain advantage of 0.114 kg over the 148 day period. A 67-98% reduction in pasture larval nematode contamination occurred on pastures grazed by the treated animals, as indicated by the parasite burden in tracer calves and pasture larval counts. The treatment effect was eventually lost by the following spring since tracer calves on the treated pasture had only 33% fewer nematodes than those on the control pasture.
authors.affiliation: College of Veterinary Medicine, Oregon State University, Corvallis 97331.
authors.forename: L G
authors.initials: LG
authors.lastname: Rickard
authors.forename: G L
authors.initials: GL
authors.lastname: Zimmerman
authors.forename: E P
authors.initials: EP
authors.lastname: Hoberg
authors.forename: D H
authors.initials: DH
authors.lastname: Wallace
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000378:metabolism; D003692:Delayed-Action Preparations; D005260:Female; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D015430:Weight Gain
chemical_list: D003692:Delayed-Action Preparations; D007559:Ivermectin