title: Comparison of prednisolone and placebo in subfertile men with antibodies to spermatozoa.
abstract: 43 subfertile men with circulating antibodies to spermatozoa entered a double-blind crossover trial and received soluble prednisolone (20 mg twice daily on days 1-10 of the female partner's menstrual cycle, followed by 5 mg on days 11 and 12) or matching placebo tablets for 9 months each. 9 pregnancies were produced by men during prednisolone treatment, compared with 2 by men randomised to placebo (although only 1 was actually taking the placebo). No serious complications were produced, although 60% of those receiving prednisolone experienced mild side-effects.
authors.affiliation: Queen Charlotte's Hospital for Women, London, UK.
authors.forename: W F
authors.initials: WF
authors.lastname: Hendry
authors.forename: L
authors.initials: L
authors.lastname: Hughes
authors.forename: G
authors.initials: G
authors.lastname: Scammell
authors.forename: J P
authors.initials: JP
authors.lastname: Pryor
authors.forename: T B
authors.initials: TB
authors.lastname: Hargreave
mesh_terms: D000372:Agglutination Tests; D001323:Autoantibodies / Q000032:analysis*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008597:Menstrual Cycle; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000276:immunology*; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D011239:Prednisolone