Direct interaction between human endometrial carcinoma and fibroblast: fibroblast-derived growth factor.
Epithelial-stromal interaction was investigated in human endometrial carcinoma. The medium cultured with fibroblasts derived from human endometrial carcinoma tissue increased [3H]thymidine incorporation into and estrogen receptor level of endometrial carcinoma (Hashimoto) cells. Concomitant exposure to estradiol, but not to progesterone, synergistically enhanced the conditioned medium-induced events. These findings demonstrated direct interaction of epithelial cells and its stromal cells in endometrial carcinoma.
Tamaya
T
T
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Sato
S
S
Imai
A
A
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D003470:Culture Media; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D011960:Receptors, Estrogen / Q000032:analysis; D013936:Thymidine / Q000378:metabolism / Q000493:pharmacokinetics; D014316:Tritium; D014407:Tumor Cells, Cultured
D003470:Culture Media; D011960:Receptors, Estrogen; D014316:Tritium; D005346:Fibroblast Growth Factors; D013936:Thymidine