title: 19F nuclear magnetic resonance spectroscopy of neuroleptics: the first in vivo pharmacokinetics of trifluoperazine in the rat brain and the first in vivo spectrum of fluphenazine in the human brain.
abstract: In vivo 19F nuclear magnetic resonance (19F-NMR) spectroscopy measurements of trifluorinated neuroleptics (fluphenazine--FL and trifluoperazine--TFP) were made in rat brain as well as in human brain. Animal studies were performed at 4.7 Tesla. Using rats that have been treated with FL over a period of 3 weeks, a NMR signal could be detected within 8-15 min. Following a single intravenous injection of TFP, brain levels could be monitored with a time resolution of 30 min. The first 19F-NMR examination of a patient was made at 3.0 Tesla 1 day after injection of FL decanoate (37.5 mg) in the course of which a signal could be detected within 30 min. It is expected that 19F-NMR will become an important tool in psychopharmacological research.
authors.affiliation: Department of Psychiatry, University of Tübingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Bartels
authors.forename: U
authors.initials: U
authors.lastname: Günther
authors.forename: K
authors.initials: K
authors.lastname: Albert
authors.forename: K
authors.initials: K
authors.lastname: Mann
authors.forename: N
authors.initials: N
authors.lastname: Schuff
authors.forename: H
authors.initials: H
authors.lastname: Stuckstedte
mesh_terms: D000328:Adult; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D005476:Fluphenazine / Q000493:pharmacokinetics*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D014268:Trifluoperazine / Q000493:pharmacokinetics*
chemical_list: D014268:Trifluoperazine; D005476:Fluphenazine