title: [Multifactorial experiment on the combined effect of rifampicin and microbial polysaccharide in experimental plague infection].
abstract: Multifactorial analysis was applied to the study of the combined effect of rifampicin and a microbial polysaccharide in experimental plague infection. The effect of the antibiotic and immunomodulator was shown to be synergistic. On the basis of the study results polynomial statistic models of the second order were designed and nomograms or equal level lines were plotted which provided optimization of the combined chemo- and immunotherapy.
authors.forename: A V
authors.initials: AV
authors.lastname: Nikitin
authors.forename: L N
authors.initials: LN
authors.lastname: Makarovskaia
authors.forename: I P
authors.initials: IP
authors.lastname: Fomina
authors.forename: L P
authors.initials: LP
authors.lastname: Ivanitskaia
authors.forename: G O
authors.initials: GO
authors.lastname: Popova
authors.forename: N N
authors.initials: NN
authors.lastname: Vinidchenko
authors.forename: Ia N
authors.initials: IaN
authors.lastname: Korganov
authors.forename: S E
authors.initials: SE
authors.lastname: Gorin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D003627:Data Interpretation, Statistical; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D051379:Mice; D010930:Plague / Q000188:drug therapy*; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D012240:Rhodococcus; D012293:Rifampin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D011135:Polysaccharides, Bacterial; D012293:Rifampin
vernacular_title: Izuchenie v mnogofaktornom ékperimente sochetannogo deĭstviia rifampitsina i polisakharida mikrobnogo proiskhozhdeniia pri éksperimental'noĭ chumnoĭ infektsii.