Regulation of the mevalonate pathway.
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.
Goldstein
J L
JL
Departments of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235.
Brown
M S
MS
D000818:Animals; D002455:Cell Division; D002784:Cholesterol / Q000096:biosynthesis; D005204:Farnesol / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics; D006904:Hydroxymethylglutaryl-CoA Synthase / Q000235:genetics; D008798:Mevalonic Acid / Q000378:metabolism*; D011973:Receptors, LDL / Q000235:genetics; D013261:Sterols / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects
D011973:Receptors, LDL; D013261:Sterols; D005204:Farnesol; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D006904:Hydroxymethylglutaryl-CoA Synthase; D008798:Mevalonic Acid