Hypothesis: Helicobacter pylori, urease, mucus, and gastric ulcer.
Ammonia, released in the gastric mucosa by the action of Helicobacter pylori urease on transuded plasma urea, curtails the biosynthesis of mucus and/or causes the mucus to be disassembled at the mucosal surface. These changes facilitate colonisation by H pylori and may promote gastric ulcer formation.
Sidebotham
R L
RL
Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Baron
J H
JH
D002167:Campylobacter / Q000201:enzymology*; D002169:Campylobacter Infections / Q000150:complications*; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D013276:Stomach Ulcer / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D014510:Urease / Q000378:metabolism*
D014510:Urease