Nifedipine increases urinary excretion of prostacyclin metabolite in hypertensive pregnancy.
Renal prostanoid excretion was investigated in nine hypertensive pregnant patients before and during treatment with nifedipine 10 mg orally t.i.d. Urinary excretion of prostacyclin (measured as 6-ketoprostaglandin F1 alpha, 6-keto-PGF1 alpha) increased by 77% during nifedipine treatment (P less than 0.05). No changes were found in prostaglandin E2 (PGE2) and thromboxane A2 (as thromboxane B2, TXB2) excretions. A significant reduction in blood pressure did not correlate with an increase in 6-keto-PGF1 alpha excretion. Plasma prekallikrein and urinary kallikrein and catecholamine excretions remained unaltered. In six normotensive non-pregnant women, increase in 6-keto-PGF1 alpha excretion during nifedipine treatment was not significant. No changes in PGE2 and TXB2 excretions were found, whereas plasma prekallikrein was reduced (P less than 0.05) and urinary excretion of kallikrein (P less than 0.05) and noradrenaline (P = 0.06) increased under nifedipine. The results suggest that nifedipine enhances the renal 6-keto-PGF1 alpha excretion in hypertensive pregnancy.
Manninen
A
A
Department of Biomedical Sciences, University of Tampere, Finland.
Metsä-Ketelä
T
T
Tuimala
R
R
Vapaatalo
H
H
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D015232:Dinoprostone / Q000652:urine; D011464:Epoprostenol / Q000652:urine*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000652:urine*; D007610:Kallikreins / Q000652:urine; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy / Q000652:urine*; D011453:Prostaglandins / Q000652:urine; D013929:Thromboxane B2 / Q000652:urine
D002395:Catecholamines; D011453:Prostaglandins; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D003404:Creatinine; D011464:Epoprostenol; D007610:Kallikreins; D009543:Nifedipine; D015232:Dinoprostone