Oestrogen receptors in conjunctival malignant melanoma: immunocytochemical study using formalin fixed paraffin wax sections.
In a group of 15 women with conjunctival malignant melanoma six cases (40%) were shown to have oestrogen receptor positivity using a monoclonal antibody to oestrogen receptor related antigen (ER-D5, Amersham RPN.710) on formalin fixed, paraffin wax sections. Receptors were also present in the epithelium of these six cases but not in controls and cases without ER-D5 positivity in their tumours. A subset of these aggressive, intractable unilateral tumours may therefore be amenable to hormone treatment.
Paridaens
D A
DA
Department of Pathology, London.
Alexander
R A
RA
Hungerford
J L
JL
McCartney
A C
AC
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D003230:Conjunctival Neoplasms / Q000737:chemistry*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008545:Melanoma / Q000737:chemistry*; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000737:chemistry*; D016612:Paraffin Embedding; D011960:Receptors, Estrogen / Q000032:analysis*; D012189:Retrospective Studies
D000911:Antibodies, Monoclonal; D011960:Receptors, Estrogen