[The effect of adrenocorticotropic hormone (ACTH) and cycloheximide (CHM) on lipid biosynthesis in the rat lung].
The influence of ACTH, CHM and of ACTH + CHM was studied on lipid metabolism of lungs of rats by usage of a radioactive precursor 14C-acetate. It was established that the biosynthesis of total lipids, of triacylglycerols as well as of free fatty acids was increased under the influence of ACTH and CHM as this effect was mostly manifested after combined action of ACTH and CHM. The investigated factors manifested inhibiting effect on the synthesis of free cholesterol and total phospholipids. ACTH stimulated incorporation of 14C-acetate in the glycerol part of triacylglycerols as well as of the total phospholipids, while CHM and the combination of CHM and ACTH had inhibiting effect on the biosynthesis of the glycerol part of triacylglycerols and of total phospholipids.
Vasileva-Dimova
M
M
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002250:Carbon Radioisotopes; D003513:Cycloheximide / Q000494:pharmacology*; D004347:Drug Interactions; D008055:Lipids / Q000096:biosynthesis*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D008055:Lipids; D000324:Adrenocorticotropic Hormone; D003513:Cycloheximide
Vliianie na adrenokortikotropniia khormon (AKTKh) i na tsiklokheksimid (TsKhM) vŭrkhu biosinteza na lipidi v bial drob na plŭkh.