Urinary surge of human luteinizing hormone in infertile women.
An improved semiquantitative immunoassay method allows human luteinizing hormone (hLH) in urine to be detected from 2.5 to 640 mIU/ml has developed. With this method, the hLH surges in every 3 h urine samples while awake were measured in 8 normal and 12 infertile women. The result was that the urinary hLH surge in infertility was insufficient regardless of the high urinary E2 value. This result may play, at least in part, an etiologic role in infertility.
Okamura
T
T
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan.
Kigasawa
K
K
Takeuchi
T
T
Nishii
O
O
Yaginuma
T
T
D000328:Adult; D004958:Estradiol / Q000652:urine; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006801:Humans; D007118:Immunoassay / Q000379:methods; D007247:Infertility, Female / Q000188:drug therapy / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000652:urine*; D008597:Menstrual Cycle / Q000502:physiology; D010902:Pituitary Gland / Q000378:metabolism; D011276:Pregnanediol / Q000652:urine
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone; D011276:Pregnanediol