Growth factors in pathogenesis of coronary arterial restenosis.
Restenosis occurs in 25% to 55% of patients within 6 months of successful angioplasty. The major histologic component of the restenotic lesion is intimal hyperplasia, which is almost certainly driven by growth factors. After vascular injury, smooth muscle cells proliferate, reaching a maximum rate at day 2. Smooth muscle cell proliferation diminishes as the vessel surface is re-endothelialized at about day 7, and by week 4 the smooth muscle cell mitotic rate returns to baseline of less than 1% per day. The events of the histologic evolution of arterial injury can be used to create a hypothetical paradigm for the role of growth factors in restenosis. Restenosis might logically be prevented by an inhibitory intervention at any of the various steps in the healing process.
Cercek
B
B
Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Sharifi
B
B
Barath
P
P
Bailey
L
L
Forrester
J S
JS
D000818:Animals; D002455:Cell Division; D003324:Coronary Artery Disease / Q000209:etiology / Q000473:pathology*; D004714:Endometrial Hyperplasia / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D012008:Recurrence
D006133:Growth Substances; D010982:Platelet-Derived Growth Factor; D007334:Insulin-Like Growth Factor I