19F nuclear magnetic resonance spectroscopy of neuroleptics: the first in vivo pharmacokinetics of trifluoperazine in the rat brain and the first in vivo spectrum of fluphenazine in the human brain.
In vivo 19F nuclear magnetic resonance (19F-NMR) spectroscopy measurements of trifluorinated neuroleptics (fluphenazine--FL and trifluoperazine--TFP) were made in rat brain as well as in human brain. Animal studies were performed at 4.7 Tesla. Using rats that have been treated with FL over a period of 3 weeks, a NMR signal could be detected within 8-15 min. Following a single intravenous injection of TFP, brain levels could be monitored with a time resolution of 30 min. The first 19F-NMR examination of a patient was made at 3.0 Tesla 1 day after injection of FL decanoate (37.5 mg) in the course of which a signal could be detected within 30 min. It is expected that 19F-NMR will become an important tool in psychopharmacological research.
Bartels
M
M
Department of Psychiatry, University of Tübingen, Germany.
Günther
U
U
Albert
K
K
Mann
K
K
Schuff
N
N
Stuckstedte
H
H
D000328:Adult; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D005476:Fluphenazine / Q000493:pharmacokinetics*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D014268:Trifluoperazine / Q000493:pharmacokinetics*
D014268:Trifluoperazine; D005476:Fluphenazine