title: Regulation of the mevalonate pathway.
abstract: The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.
authors.affiliation: Departments of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235.
authors.forename: J L
authors.initials: JL
authors.lastname: Goldstein
authors.forename: M S
authors.initials: MS
authors.lastname: Brown
mesh_terms: D000818:Animals; D002455:Cell Division; D002784:Cholesterol / Q000096:biosynthesis; D005204:Farnesol / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics; D006904:Hydroxymethylglutaryl-CoA Synthase / Q000235:genetics; D008798:Mevalonic Acid / Q000378:metabolism*; D011973:Receptors, LDL / Q000235:genetics; D013261:Sterols / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D011973:Receptors, LDL; D013261:Sterols; D005204:Farnesol; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D006904:Hydroxymethylglutaryl-CoA Synthase; D008798:Mevalonic Acid