title: Variable association of HLA-A2 in men with early-onset Alzheimer disease.
abstract: In the present study, we attempted to replicate the finding of an increased frequency of HLA-A2 in men with early-onset (less than or equal to 60 years) Alzheimer disease (AD). HLA data obtained on 167 patients (including 19 men with early-onset AD) from three geographic regions (North Carolina, Great Britain, and Finland) failed to replicate the result. A recent prospective study from Oregon, however, confirmed the association. Studies demonstrating the association suggest its presence in sporadic rather than familial AD. These results indicate a variable HLA/AD association, with some factor such as geographic region or disease familiality contributing to this variability.
authors.affiliation: UCLA Neuropsychiatric Institute, Los Angeles, CA 90024.
authors.forename: G W
authors.initials: GW
authors.lastname: Small
authors.forename: S C
authors.initials: SC
authors.lastname: Ebeling
authors.forename: S S
authors.initials: SS
authors.lastname: Matsuyama
authors.forename: A
authors.initials: A
authors.lastname: Heyman
authors.forename: E G
authors.initials: EG
authors.lastname: Reisner
authors.forename: E B
authors.initials: EB
authors.lastname: Renvoize
authors.forename: R
authors.initials: R
authors.lastname: Sulkava
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000276:immunology*; D005260:Female; D015789:HLA-A2 Antigen / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D015789:HLA-A2 Antigen