Detection of carcinogenic glutamic acid pyrolysis products in cigarette smoke condensate.
Carcinogenic glutamic acid pyrolysis products were measured in condensate of cigarette mainstream smoke by HPLC. These carcinogens were found to be present in all brands of filter-tipped cigarette analyzed. The mean levels of 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-aminodipyridol[1,2-a:3',2'-d]imidazole in the cigarette mainstream smoke were 0.66 and 0.63 ng/cig respectively.
Kanai
Y
Y
Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo, Japan.
Wada
O
O
Manabe
S
S
D002273:Carcinogens / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005971:Glutamates; D018698:Glutamic Acid; D007093:Imidazoles / Q000032:analysis*; D007564:Japan; D013058:Mass Spectrometry; D009153:Mutagens / Q000032:analysis*; D012906:Smoke / Q000032:analysis*; D012907:Smoking; D014481:United States
D002273:Carcinogens; D005971:Glutamates; D007093:Imidazoles; D009153:Mutagens; D012906:Smoke; D018698:Glutamic Acid; C023785:2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole; C023847:Glu-P-2