Determination of remoxipride in plasma and urine by reversed-phase column liquid chromatography.
A reversed-phase column liquid chromatographic method for the determination of remoxipride, a novel antipsychotic drug, in biological fluids is described. A simple one-step extraction is used followed by liquid chromatography on a 3-microns octadecylsilica column and ultraviolet absorbance detection. The method is accurate and precise for clinical remoxipride levels in both plasma and urine. For situations where a higher sensitivity is necessary a two-step extraction and a modified mobile phase are used. With this modification plasma concentrations down to 2 nM can be determined with acceptable precision.
Nilsson
L B
LB
Bioanalysis, Astra Research Centre AB, Södertälje, Sweden.
D014150:Antipsychotic Agents / Q000097:blood* / Q000493:pharmacokinetics / Q000652:urine; D001549:Benzamides / Q000097:blood* / Q000493:pharmacokinetics / Q000652:urine; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D017330:Remoxipride
D014150:Antipsychotic Agents; D001549:Benzamides; D017330:Remoxipride