title: Multidrug resistance due to P-glycoprotein.
abstract: P-glycoprotein is a cell membrane transport protein in various human tissues that acts as an efflux pump, apparently to protect normal cells from environmental toxins. It is also a mechanism used by some cancer cells to resist chemotherapy. The gene responsible for P-glycoprotein is partially defined. Agents that inhibit the protein in tumors may make chemotherapy more effective and less toxic.
authors.affiliation: Division of Cancer Etiology, National Cancer Institute.
authors.forename: R K
authors.initials: RK
authors.lastname: Burt
authors.forename: A T
authors.initials: AT
authors.lastname: Fojo
authors.forename: S S
authors.initials: SS
authors.lastname: Thorgeirsson
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002463:Cell Membrane Permeability / Q000502:physiology; D002874:Chromosome Mapping; D004351:Drug Resistance / Q000235:genetics / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D015723:Gene Library; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics*; D014162:Transfection
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins