Essential fatty acid status and fluidity of plasma phospholipids in cystic fibrosis infants.
The fatty acid (FA) patterns of cord serum phospholipids (PLs) were examined in 4 cystic fibrosis (CF) newborns, 8 non-CF siblings, and 22 normal control subjects. Plasma from 27 newly diagnosed CF infants and 38 normal infants aged less than 2 y were studied for comparison. CF cord-blood PLs had patterns similar to those of CF siblings and to normal newborns, but the pattern for CF did not shift toward adult patterns during infancy as did patterns for normal infants. CF infants at diagnosis exhibited a deficiency pattern in which 18: 2 omega 6, 20:4 omega 6, 22:4 omega 6, an omega 3 polyunsaturated fatty acids (PUFAs) were significantly subnormal and 18:3 omega 6, total saturated fatty acids, and total monounsaturated fatty acids were significantly elevated compared with normal infants. In PLs in CF infants, although mean chain length of FAs was low, mean melting point was elevated 2.4 degrees C and double-bond index was low (both P less than 0.001), implying a significantly lessened fluidity. Nutritional supplements of both omega 6 and omega 3 PUFAs are cated.
Lloyd-Still
J D
JD
Division of Gastroenterology, Children's Memorial Hospital, Northwestern University, Chicago, IL 60614.
Johnson
S B
SB
Holman
R T
RT
D000375:Aging / Q000097:blood; D003550:Cystic Fibrosis / Q000097:blood* / Q000235:genetics; D005228:Fatty Acids, Essential / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005312:Fetal Blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010743:Phospholipids / Q000097:blood* / Q000502:physiology; D012016:Reference Values
D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D010743:Phospholipids