Does reversed-type anaphylaxis in healthy subjects mimic a real allergic reaction?
Immediate and late cutaneous reactions were induced in healthy and atopic subjects by anti-IgE challenge and a skin-window technique was used in order to verify if the pattern of cells observed at 24 hr was similar in both groups. The study was first performed under basal conditions, and in a second double-blind cross-over step, it was performed again during treatment with cetirizine 10 mg b.i.d. and terfenadine 60 mg b.i.d. Anti-IgE challenge was followed by a significant eosinophil accumulation in atopic subjects only. Cetirizine significantly inhibited this phenomenon while terfenadine showed a mild non-significant inhibitory effect.
Henocq
E
E
Rue Beaujon, Paris, France.
Rihoux
J P
JP
D000293:Adolescent; D000328:Adult; D000707:Anaphylaxis / Q000276:immunology*; D000937:Antigen-Antibody Reactions / Q000187:drug effects / Q000276:immunology*; D002465:Cell Movement / Q000187:drug effects; D017332:Cetirizine; D004311:Double-Blind Method; D004804:Eosinophils / Q000032:analysis; D005260:Female; D006634:Histamine H1 Antagonists / Q000276:immunology / Q000494:pharmacology*; D006801:Humans; D006919:Hydroxyzine / Q000031:analogs & derivatives* / Q000276:immunology / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D011897:Random Allocation; D012867:Skin / Q000166:cytology / Q000276:immunology; D012884:Skin Window Technique
D006634:Histamine H1 Antagonists; D006919:Hydroxyzine; D007073:Immunoglobulin E; D017332:Cetirizine