[Desensitization of the alpha 1-adrenergic reaction under the action of noradrenaline in increasing concentrations].
The kinetics of alpha 1-adrenergic response to noradrenaline in a wide range of concentrations upon the cumulative and discrete addition of noradrenaline, was studied in isolated epididymal sections of the rat vas deferens. Two pools of alpha 1-adrenoceptors differing in their affinity to noradrenaline were revealed in both cases. The desensitisation of both pools of alpha 1-adrenoceptors is shown during the adrenergic reaction upon the cumulative addition of noradrenaline. The desensitisation is expressed in the decrease of the number of active receptors.
Berdysheva
L V
LV
Khakimova
D Kh
DKh
Manukhin
B N
BN
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004822:Epididymis / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000502:physiology; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology
D011942:Receptors, Adrenergic, alpha; D009638:Norepinephrine
Desensitizatsiia al'fa 1-adrenergicheskoĭ reaktsii pri deĭstvii noradrenalina v narastaiushchikh kontsentratsiiakh.