Blockade of the glycine modulatory site of NMDA receptors modifies dynorphin-induced behavioral effects.
Intrathecal (i.t.) administration of the opioid dynorphin causes neurological dysfunction and tissue damage. It has been suggested that these effects of dynorphin may be mediated, in part, by N-methyl-D-aspartate (NMDA) receptors. In the present studies, recently developed compounds that block the glycine potentiation site of the NMDA receptor (Gly-NMDA site), including the competitive antagonist 5-fluoro-indole-2-carboxylic acid and the non-competitive antagonist 7-chlorokynurenic acid, prevented the neurologic deficits and mortality caused by i.t. dynorphin A(1-17). These findings are consistent with the hypothesis that dynorphin-induced neurological dysfunction involves activation of NMDA receptors. Moreover, blockade of the Gly-NMDA site may provide an alternative to blockade of the glutamate binding site or NMDA receptor ion channel as an in vivo pharmacological strategy to treat conditions previously associated with excitotoxin mediated tissue injury.
Bakshi
R
R
Department of Neurology, University of California, San Francisco.
Faden
A I
AI
D000818:Animals; D004399:Dynorphins / Q000633:toxicity*; D005998:Glycine / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology* / Q000627:therapeutic use; D007278:Injections, Spinal; D007736:Kynurenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D010243:Paralysis / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D007211:Indoles; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; C063768:5-fluoroindole-2-carboxylic acid; D004399:Dynorphins; D007736:Kynurenic Acid; C057013:7-chlorokynurenic acid; D005998:Glycine