[The characteristics of the serotoninergic regulation of gastric secretion and hemostasis in patients with duodenal peptic ulcer].
Results of a study of 59 patients with duodenal ulcer indicate that the blockader of serotoninergic receptors peritol (P) increases approximately two times the rheological properties of gastric mucus. In patients with uncomplicated form of the disease and basal hypersecretion P inhibits averagely by 1/3 the production of acid and pepsin. At the same time patients with hemorrhagic complications in the anamnesis show a marked increase of acid and pepsin secretion and a reduction of the aggregation activity of thrombocytes induced by adrenalin.
Fisher
A A
AA
Borisov
Iu Iu
IuIu
Filipchenko
E M
EM
D000293:Adolescent; D000328:Adult; D003533:Cyproheptadine / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin; D010438:Peptic Ulcer Hemorrhage / Q000097:blood / Q000503:physiopathology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*
D011985:Receptors, Serotonin; D003533:Cyproheptadine; D010418:Pentagastrin
Osobennosti serotoninergicheskoĭ reguliatsii zheludochnoĭ sekretsii i gemostaza u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki.