Urinary neopterin concentrations and T-cell subset data in HIV-1 infection.
We investigated the ability of urinary neopterin concentrations and T-cell subset data, and their ratios to discriminate between anti-HIV-1 seronegatives, seropositives, and AIDS cases. Using receiver-operated-characteristics curves, neopterin levels were shown to provide the best discrimination. Of the ratios derived from the single variables, neopterin per CD4+ cell counts and neopterin per CD4+/CD8+ cell ratio were superior to the CD4+/CD8+ cell ratio. Multivariate analyses were performed using a generalized likelihood ratio approach as well as linear discriminant analysis. The combination of neopterin concentration and CD4+ T-cell count is well suited to discriminate between various stages of HIV-1 infection and, therefore, we recommend using more than one assay to evaluate disease progression.
Reibnegger
G
G
Institut für Medizinische Chemie und Biochemie, Universität Innsbruck, Osterreich.
Fuchs
D
D
Goedert
J J
JJ
Hausen
A
A
Krämer
A
A
Werner
E R
ER
Werner-Felmayer
G
G
Dierich
M P
MP
Wachter
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives* / Q000652:urine; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015331:Cohort Studies; D015658:HIV Infections / Q000175:diagnosis / Q000276:immunology*; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006716:Homosexuality; D006801:Humans; D008297:Male; D019798:Neopterin; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D001708:Biopterins; D019798:Neopterin