Enhanced acceptance and metabolism of fats by rats fed a high-fat diet.
Rats fed a high-fat diet show greater acceptance of and preference for pure fats than do rats fed a high-carbohydrate diet. We tested the hypothesis that this differential intake of fat was due to diet-induced modifications of lipid absorption and oxidation. After an intragastric load of corn oil, rats adapted to a high-fat diet had greater increases in plasma triglyceride and ketone levels and a lower percentage of fecal fat than did rats adapted to an isocaloric high-carbohydrate diet. High-fat-fed rats given corn oil containing [14C]palmitic acid expired 14CO2 more rapidly and to a greater extent than did rats maintained on a high-carbohydrate diet. These results show that the greater acceptance of fat by rats fed a high-fat diet is associated with an increased capacity to absorb and oxidize fat.
Reed
D R
DR
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104-3308.
Tordoff
M G
MG
Friedman
M I
MI
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003314:Corn Oil; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004041:Dietary Fats / Q000378:metabolism* / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007657:Ketone Bodies / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D007657:Ketone Bodies; D014280:Triglycerides; D003314:Corn Oil