Enantio-oligodeoxyribonucleotides.
As a sugar-modified oligonucleotide, a hexamer of 9-(2-deoxy-beta-L-erythro-pentafuranosyl)-9H-purin-6-amine, [L-(dAp)5dA], was synthesized by triester method. The L-hexamer was resistant to bovine spleen phosphodiesterase. UV absorption studies indicated that L-hexamer formed a complex with poly U but not with poly dT at 0 degrees C. It was assumed that enantio-DNA's possese the ability to distinguish complementary RNA from DNA.
Fujimori
S
S
Faculty of Pharmaceutical Science, University of Tokyo, Japan.
Shudo
K
K
Hashimoto
Y
Y
D000227:Adenine Nucleotides / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D002417:Cattle; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D011071:Poly T / Q000378:metabolism; D011072:Poly U / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D013154:Spleen / Q000201:enzymology
D000227:Adenine Nucleotides; D009838:Oligodeoxyribonucleotides; D011071:Poly T; D011072:Poly U; D010727:Phosphoric Diester Hydrolases