title: ACTH(1-24) stimulates the migration of human monocytes in vitro.
abstract: In view of the increasing evidence that a variety of stresses can influence immune responses, the direct effect of adrenocorticotropic hormone on the migration of human monocytes was studied in vitro. ACTH(1-24) significantly increased the number of migrating cells when placed in the same or the opposite compartment of the chemotaxis chamber, maximum activity being obtained at 10(-14) and 10(-8) M. The results indicate that ACTH(1-24) directly and potently stimulates the migration of human monocytes by means of a chemokinetic effect.
authors.affiliation: Institute of Pharmacology, University of Modena, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Genedani
authors.forename: M
authors.initials: M
authors.lastname: Bernardi
authors.forename: M G
authors.initials: MG
authors.lastname: Baldini
authors.forename: A
authors.initials: A
authors.lastname: Bertolini
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000704:Analysis of Variance; D002465:Cell Movement / Q000187:drug effects; D003366:Cosyntropin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology
chemical_list: D003366:Cosyntropin; D009240:N-Formylmethionine Leucyl-Phenylalanine; D000324:Adrenocorticotropic Hormone