title: The renin-secreting cell in polyarteritis--an immunocytochemical study.
abstract: We studied kidney sections from 15 cases of polyarteritis using an immunocytochemical technique to demonstrate cells containing immunoreactive renin. Ten cases of classical polyarteritis nodosa showed hyperplasia of renin-containing cells in areas of renal cortex with histological evidence of ischaemia--appearances indistinguishable from those seen in renal artery stenosis. Histologically normal cortex showed little or no immunostainable renin. In the ischaemic areas there was loss of the normal gradient of renin-containing cells from superficial to deep cortex. In many cases this gradient was abolished or even reversed; in some cases most renin-containing cells were in juxtaglomerular apparatuses. This alteration in the distribution of immunoreactive renin has only been described in renal artery stenosis in man. In five cases of microscopic polyarteritis there were fewer than normal numbers of renin-containing cells. We suggest that in classical polyarteritis nodosa, focal ischaemia causes activation of the renin-angiotensin system analogous to the changes caused by renal artery stenosis. This may be important in the pathogenesis of hypertension in this condition. By contrast, in microscopic polyarteritis, the appearances of the juxtaglomerular apparatus and the reduced amounts of immunostainable renin suggest suppression of renin synthesis.
authors.affiliation: Department of Morbid Anatomy, King's College Hospital, London, UK.
authors.forename: P C
authors.initials: PC
authors.lastname: Graham
authors.forename: G B
authors.initials: GB
authors.lastname: Lindop
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D006965:Hyperplasia; D006977:Hypertension, Renal / Q000209:etiology; D007150:Immunohistochemistry; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000473:pathology / Q000503:physiopathology*; D012083:Renin / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000502:physiology
chemical_list: D012083:Renin