title: Growth kinetics of fibroblasts from a patient with Ehlers-Danlos syndrome.
abstract: A 6-year-old girl with Ehlers-Danlos syndrome (type I) who shows hyperelastic skin, hypermobile joints and delayed wound healing is reported. The growth kinetics of fibroblasts derived from her skin was examined using 3H-thymidine autoradiography. Our study showed that these fibroblasts had poor proliferative activity, compared with normal age-matched fibroblasts. Thus, we could suggest that the pathogenesis of Ehlers-Danlos syndrome was partially attributed to the lack of proliferative activity of the fibroblasts.
authors.affiliation: Department of Dermatology, Shizuoka General Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oku
authors.forename: F
authors.initials: F
authors.lastname: Nakayama
authors.forename: M
authors.initials: M
authors.lastname: Takigawa
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Yamada
mesh_terms: D001345:Autoradiography; D002455:Cell Division; D002478:Cells, Cultured; D002648:Child; D004535:Ehlers-Danlos Syndrome / Q000209:etiology / Q000473:pathology*; D005260:Female; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D012867:Skin / Q000473:pathology