[Mode of action of hypoglycemic sulfanilamides].
Sulfonylureas act as hypoglycemic agents by stimulating insulin secretion and improving insulin sensibility by a post-receptor mechanism. Their long term results mainly depend on extra-pancreatic mechanisms. Moreover they indirectly decrease triglyceridemia. Glipizide and gliclazide enhance fibrinolysis. Gliclazide also inhibits platelet aggregation and adhesion. The best indication of sulfonylureas is non insulin dependent diabetes with normal weight.
Girardin
E
E
Hôpital de jour d'Endocrinologie, Hôpital de la Conception, Marseille.
Conte Devolx
B
B
D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005342:Fibrinolysis / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007003:Hypoglycemia / Q000188:drug therapy / Q000209:etiology; D007328:Insulin / Q000378:metabolism; D013453:Sulfonylurea Compounds / Q000494:pharmacology / Q000627:therapeutic use*
D007328:Insulin; D013453:Sulfonylurea Compounds; D005947:Glucose
Mode d'action des sulfamides hypoglycémiants.