Imipramine inhibits monoamine oxidase activity in hyperglycemic rat brain.
The effect of the chronic treatment of tricyclic antidepressants like Imipramine on the catecholamine metabolism of rat brain, in normal and hyperglycemic conditions was investigated. Imipramine was found to elevate the catecholamine levels in controls, while chronic treatment of hyperglycemic animals with the drug, failed to cause any change other than seen as a result of hyperglycemia. The activities of Monoamine oxidase on the other hand, decreases significantly as a result of the treatment, both in controls and in the hyperglycemic state. The results suggest that the drug apart from acting as an antidepressant, assumes the role of a monoamine oxidase inhibitor under pathological conditions.
Gupta
G
G
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Azam
M
M
Sonone
S R
SR
Baquer
N Z
NZ
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D006943:Hyperglycemia / Q000201:enzymology*; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D008996:Monoamine Oxidase Inhibitors; D007099:Imipramine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine