title: Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis.
abstract: Based on the concept that proteolytic enzymes, like cathepsins, are associated with tissue destruction, we investigated the expression of the matrix-degrading cysteine proteinase cathepsin B in synovial tissues from the joints of patients with rheumatoid arthritis. The data indicate an enhanced transcription of cathepsin B in synovial cells when compared with normal fibroblasts, cathepsin B-producing epithelial tumor cells (SW1116), or fibroblasts derived from inflamed tonsils. Immunolocalization of cathepsin B appeared to be restricted mainly to the synovial cells attached to cartilage and bone at sites of rheumatoid joint erosion.
authors.affiliation: Department of Medicine, University of Alabama, Birmingham 35294.
authors.forename: A
authors.initials: A
authors.lastname: Trabandt
authors.forename: R E
authors.initials: RE
authors.lastname: Gay
authors.forename: H G
authors.initials: HG
authors.lastname: Fassbender
authors.forename: S
authors.initials: S
authors.lastname: Gay
mesh_terms: D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D002401:Cathepsin B / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D006801:Humans; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000032:analysis; D013583:Synovial Membrane / Q000201:enzymology*
chemical_list: D012333:RNA, Messenger; D002401:Cathepsin B