title: [Locoregional recurrences following curative surgery for colon cancer].
abstract: This study explores the patterns of local recurrence after curative operations for colonic cancer. Over a 13 year period (1976-1988) 486 patients were operated on in the Surgical Clinic of Parma University for colonic cancer, but only 296 patients who underwent potentially curative resection were examined. The influence of patients' age, disease stage, site and grade, presence of obstruction or perforation and type of surgical procedures were examined as prognostic factors for local cancer recurrence. A total of 28 patients (14%) relapsed after surgery and 19 were found to have simultaneous distant metastasis. 86% of recurrences were evident within the first 2 years. Local recurrence rate increased with more advanced Duke's stage and stage of the primary tumour was most predictive for eventual relapse. The recurrences occurred within the operative resection site involving the anastomosis by inward growth at the suture line. Minute foci of adenocarcinoma not encompassed by the first operation might lead to local recurrences; the authors do not rule out, however, the rare possibility of the implantation of exfoliated malignant cells. Despite the attempt to carry out an intensive followup in terms of early diagnosis of recurrence in colonic surgery, the presence of local recurrences is associated with extremely poor prognosis independent of operative procedure performed. The authors believe that routine adjuvant radiation therapy after surgical treatment of locally advanced colonic cancer could improve survival rate.
authors.affiliation: Istituto di Clinica Chirurgica Generale e Terapia Chirurgica, Università di Parma.
authors.forename: A
authors.initials: A
authors.lastname: Peracchia
authors.forename: L
authors.initials: L
authors.lastname: Sarli
authors.forename: F
authors.initials: F
authors.lastname: Carreras
authors.forename: N
authors.initials: N
authors.lastname: Pietra
authors.forename: E
authors.initials: E
authors.lastname: Longinotti
authors.forename: M
authors.initials: M
authors.lastname: Gafà
mesh_terms: D000367:Age Factors; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology; D009367:Neoplasm Staging; D011184:Postoperative Period; D012737:Sex Factors
vernacular_title: Recidive loco-regionali dopo chirurgia curativa per cancro del colon.