title: Mechanism of hypercalciuria in essential hypertension and in primary nephrolithiasis.
abstract: We have studied the metabolic response to changes in calcium in 15 hypercalciuric essential hypertensives, in 8 normotensive hypercalciuric stone formers and in 11 normotensive healthy subjects matched for age and sex. At variance with hypercalciuric stone formers, at low calcium intake hypercalciuric hypertensives did not appropriately reduce urinary calcium excretion and developed mild hypocalcemia. Furthermore, the PTH response to calcium deprivation was not appropriately enhanced in these patients. The data indicate that different mechanisms prevail in these two forms of hypercalciuria: the renal in essential hypertension and the intestinal in urolithiasis.
authors.affiliation: Divisione di Nefrologia e Centro di Fisiologia Clinica, Reggio Calabria, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Zoccali
authors.forename: F
authors.initials: F
authors.lastname: Mallamaci
authors.forename: G
authors.initials: G
authors.lastname: Curatola
authors.forename: F
authors.initials: F
authors.lastname: Cuzzola
authors.forename: M
authors.initials: M
authors.lastname: Postorino
authors.forename: S
authors.initials: S
authors.lastname: Parlongo
authors.forename: F
authors.initials: F
authors.lastname: Salnitro
authors.forename: A
authors.initials: A
authors.lastname: Curatola
mesh_terms: D000328:Adult; D002118:Calcium / Q000652:urine*; D002136:Calcium, Dietary / Q000008:administration & dosage; D004573:Electrolytes / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000652:urine*; D007669:Kidney Calculi / Q000652:urine*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011188:Potassium / Q000652:urine
chemical_list: D002136:Calcium, Dietary; D004573:Electrolytes; D010281:Parathyroid Hormone; D011188:Potassium; D002118:Calcium