Biologically active metabolites from Xenorhabdus spp., Part 2. Benzopyran-1-one derivatives with gastroprotective activity.
Two novel antibiotic compounds, named xenocoumacins 1 [2] and 2 [3], with potent antiulcer activity were isolated from cultures of Xenorhabdus spp. Both compounds exhibit antibacterial activity and potent antiulcer activity against stress-induced ulcers when dosed orally. In addition, 2 has antifungal activity. Their chemical structures were determined by extensive 1H-nmr, 13C-nmr, and mass spectral studies to be 3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one derivatives.
McInerney
B V
BV
Biotech Australia Pty, Ltd., Roseville, NSW, Australia.
Taylor
W C
WC
Lacey
M J
MJ
Akhurst
R J
RJ
Gregson
R P
RP
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000302:isolation & purification; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D000935:Antifungal Agents; D001578:Benzopyrans; C071754:xenocoumacin 2; C071752:xenocoumacin 1