Chronic handling modifies the anxiolytic effect of diazepam in the elevated plus-maze.
Rats treated for 3 days with diazepam demonstrated a clear anxiolytic action of the drug as assessed in the elevated plus-maze. However, in a chronic experiment, in which all rats were handled for 28 days, no anxiolytic effect of diazepam could be shown either in rats treated for 3 days or in those treated for 28 days. These results suggest that there is an interaction between handling and the anxiolytic effect of diazepam.
Brett
R R
RR
Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, U.K.
Pratt
J A
JA
D000818:Animals; D014151:Anti-Anxiety Agents; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D006185:Habituation, Psychophysiologic; D006234:Handling, Psychological; D051381:Rats
D014151:Anti-Anxiety Agents; D003975:Diazepam