CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor.
A novel form of receptor-kinase interaction was first described in the interaction between the CD4 and CD8 antigens and the protein-tyrosine kinase p56lck. This linkage, between a regulatory antigen on T cells and a member of a family of intracellular molecules with an established ability to activate and transform cells, is likely to be of great importance in the regulation of T-cell growth. Recently, data have been obtained on the molecular basis of regulation of the CD4/CD8-p56lck interaction and an interaction between the T-cell receptor complex (TCR-CD3) and another src-kinase p59fyn has been described. Here, Christopher Rudd examines these interactions and outlines their potential roles in normal and malignant T-cell growth.
Rudd
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Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA.
D000595:Amino Acid Sequence; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism* / Q000502:physiology; D017252:CD3 Complex; D015704:CD4 Antigens / Q000378:metabolism* / Q000502:physiology; D016827:CD8 Antigens; D006801:Humans; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051076:Proto-Oncogene Proteins c-fyn; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism* / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism* / Q000502:physiology
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D011518:Proto-Oncogene Proteins; D011948:Receptors, Antigen, T-Cell; D011956:Receptors, Cell Surface; D011505:Protein-Tyrosine Kinases; C494957:FYN protein, human; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D051076:Proto-Oncogene Proteins c-fyn