[Hypercholesterolemia and hypertension--equivalent risk factors?].
Official recommendations for handling of hypercholesterolaemia are based on the comprehensive knowledge of serum cholesterol values in the healthy population as knowledge of blood pressure is desirable. To question this premise, both observational and interventional trials concerning the two risk factors are compared. Apparent similarities are produced by the fact that in hypertension trials control persons often are treated in the condition of normal care, whereas in lipid trials they are not. Early hypertension studies confirm beyond any doubt that the profit of hypotensive drugs is much higher than that of any cholesterol-lowering measure. The difference is most striking in the high-risk groups, comparing the treatment benefit in malignant hypertension with the hitherto poor results in familial hypercholesterolaemia. The author suggests a thorough analysis of all screening tests and interventional recommendations in medicine, aiming to allocate only a limited proportion of the normal population to regular medical supervision. There hypercholesterolaemia will have its modest place. Instead of intensified screening and drug treatment of healthy individuals, general advice for nutritional changes seems more reasonable.
Kaufmann
G
G
Spezialarzt für Innere Medizin FMH, Arztehaus Sonnenhof, Zürich.
D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000209:etiology; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors
D000924:Anticholesteremic Agents; D000959:Antihypertensive Agents; D002784:Cholesterol
Hypercholesterinämie und Hypertonie--gleichwertige Risikofaktoren?