title: Combined laser phototherapy and growth factor treatment of bronchial obstruction after lung transplantation.
abstract: Lung transplantation has resulted in dramatic functional improvement in patients with end-stage pulmonary diseases. Among the complications of lung transplantation are dehiscence and stenosis at the site of the bronchial or tracheal anastomosis. In this case report, we describe a single lung transplant recipient in whom partial bronchial dehiscence, followed by exuberant growth of granulation tissue, resulted in obstruction of the bronchial lumen. After mechanical dilation failed to produce lasting relief of bronchial obstruction, a novel approach to this problem was successfully employed: YAG laser phototherapy was used to remove obstructing granulation tissue, followed by application of a preparation derived from autologous blood platelets to promote epithelialization of the bronchial anastomosis. The bronchus remains patent and fully epithelialized six months after therapy.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis.
authors.forename: M I
authors.initials: MI
authors.lastname: Hertz
authors.forename: K R
authors.initials: KR
authors.lastname: Harmon
authors.forename: D R
authors.initials: DR
authors.lastname: Knighton
authors.forename: B C
authors.initials: BC
authors.lastname: Cahill
authors.forename: A J
authors.initials: AJ
authors.lastname: Duvall
authors.forename: S J
authors.initials: SJ
authors.lastname: Shumway
authors.forename: R M
authors.initials: RM
authors.lastname: Bolman
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical; D001980:Bronchi / Q000601:surgery; D001982:Bronchial Diseases / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D003251:Constriction, Pathologic; D005260:Female; D006801:Humans; D053685:Laser Therapy; D016040:Lung Transplantation; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D011183:Postoperative Complications; D014945:Wound Healing
chemical_list: D010982:Platelet-Derived Growth Factor