Effect of otic medications containing glucocorticoids on liver function test results in healthy dogs.
Otic medications containing triamcinolone or dexamethasone were administered twice daily for 21 days to 2 groups of 4 healthy dogs each. Serum alkaline phosphatase, gamma-glutamyltransferase, alanine transaminase, and aspartate transaminase activities, and serum bile acid and lipoprotein-X concentrations were assayed for 35 days. Increased serum activities for gamma-glutamyltransferase, alkaline phosphatase, and alanine transaminase were detected by day 7 and peaked at day 21. Increases were greater in dogs given the dexamethasone-containing medication. Enzyme activity returned to baseline by day 35. Serum aspartate transaminase activity and bile acid and lipoprotein-X concentrations did not increase.
Meyer
D J
DJ
Department of Medical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
Moriello
K A
KA
Feder
B M
BM
Fehrer-Sawyer
S L
SL
Maxwell
A K
AK
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001647:Bile Acids and Salts / Q000097:blood; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D004285:Dogs / Q000502:physiology*; D004423:Ear; D005260:Female; D008073:Lipoprotein-X / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D008297:Male; D014221:Triamcinolone / Q000008:administration & dosage / Q000009:adverse effects*; D005723:gamma-Glutamyltransferase / Q000097:blood
D001647:Bile Acids and Salts; D008073:Lipoprotein-X; D014221:Triamcinolone; D003907:Dexamethasone; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase