title: [Immunoactive peptide obtained from the optical ganglia of squid].
abstract: The data on the effect of a peptide from the squid optic ganglia named gangliin on some parameters of animal natural resistance are presented. It was shown that the prophylactic use of the peptide in mice 24 hours before their contamination with the lethal dose of E. coli protected 40 to 60 per cent of the animals from death. Gangliin accelerated elimination of E. coli from the host and increased the absorptive and digestive activity of the macrophages and polymorphonuclear leukocytes. With the use of gangliin it was possible to correct the phagocytosis defects in infectious processes having the phagocytic protection mechanism. Moreover, gangliin was supposed to be efficient in control of long-term persistence of various microbes in the cells of the system of mononuclear phagocytes.
authors.forename: N N
authors.initials: NN
authors.lastname: Besednova
authors.forename: T S
authors.initials: TS
authors.lastname: Zaporozhets
authors.forename: A K
authors.initials: AK
authors.lastname: Sergienko
authors.forename: N V
authors.initials: NV
authors.lastname: Krylova
authors.forename: L M
authors.initials: LM
authors.lastname: Epshteĭn
authors.forename: G A
authors.initials: GA
authors.lastname: Borovskaia
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000627:therapeutic use*; D049832:Decapodiformes; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000276:immunology; D005724:Ganglia; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009900:Optic Nerve; D010455:Peptides / Q000276:immunology / Q000627:therapeutic use*; D014020:Tissue Extracts / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D010455:Peptides; D014020:Tissue Extracts
vernacular_title: Immunoactive peptid, poluchennyĭ iz opticheskikh gangliev kal'mara.