Intestinal origin alkaline phosphatase activity in plasma for differential diagnosis of jaundice.
Intestinal origin alkaline phosphatase activity (ALP) in plasma was measured by a sensitive immunocapture assay in 104 jaundiced patients--84 with intrahepatic and 20 with post-hepatic jaundice. Increased enzyme activities were observed in those with intrahepatic disease and subnormal values in those with post-hepatic disease. At a discriminant level intestinal origin ALP showed a diagnostic sensitivity of 77% for intrahepatic cholestasis, with a diagnostic accuracy of 75% for its differentiation from post-hepatic jaundice. This diagnostic accuracy is not as good as that derived with other techniques--for example, imaging--and the technique is therefore not recommended as a supplement or replacement.
Kuwana
T
T
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London.
Rosalki
S B
SB
D000469:Alkaline Phosphatase / Q000097:blood*; D001651:Cholestasis, Extrahepatic / Q000175:diagnosis* / Q000201:enzymology; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis* / Q000201:enzymology; D003937:Diagnosis, Differential; D006801:Humans; D007118:Immunoassay; D007422:Intestines / Q000201:enzymology; D012680:Sensitivity and Specificity
D000469:Alkaline Phosphatase