Role for protein kinase C activation in IgA B cell terminal differentiation.
In the present study, we demonstrate that the PKC-activating phorbol ester PMA selectively induced IgA synthesis by PP B cells. PKC activation triggered neither B cell proliferation nor the switching rate of IgA- to IgA+ cells. Together with the fact that the rate of IgA secretion by the myeloma cell line MOPC 315 was not altered by PMA, the data demonstrate that activation of PKC enhances IgA secretion by promoting terminal differentiation of IgA-committed B cells into IgA-secreting plasma cells.
Li
Y S
YS
Laboratory of Immunology, INSERM U80, CNRS URA1177, UCBL, Hôpital E. Herriot, Lyon, France.
Dearden-Badet
M T
MT
Revillard
J P
JP
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000201:enzymology / Q000276:immunology*; D002454:Cell Differentiation; D002455:Cell Division; D004789:Enzyme Activation; D007070:Immunoglobulin A / Q000096:biosynthesis*; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology; D011493:Protein Kinase C / Q000378:metabolism*
D007070:Immunoglobulin A; D011493:Protein Kinase C