[Effect of intravenous administration of cimetidine on renal excretion of calcium, phosphates, magnesium and adenosine cyclic monophosphate].
An effect of cimetidine on parathyroid glands functioning in healthy subjects was evaluated. Serum calcium, phosphate, and magnesium concentrations together with renal excretion++ of these ions in healthy subjects as well as cAMP excretion++ in selected individuals were determined before and following intravenous administration of cimetidine (Altratmet Lek Ljublijana) in total dose of 500 mg (50 mg injected rapidly as a bolus following with 450 mg in an intravenous infusion during 60 minutes). No significant changes in serum calcium, phosphates, and magnesium concentrations were noted. Renal clearance of calcium and magnesium remained unchanged whereas renal phosphate excretion++ increased from 10.69 +/- 4.9 mL/min to 15.1 +/- 5.41 mL/min (p less than 0.02). Excretion++ of 3.5 cAMP increased from 2.65 +/- 2.19 nM/min to 5.16 +/- 2.0 nM/min (p less than 05). The obtained results do not exclude stimulating effect of intravenous cimetidine on parathyroid glands. Cimetidine given intravenously in the bleeding gastric or duodenal ulcers in the course of the primary hyperparathyroidism+ may decrease serum phosphate levels due to increased exretion of this ion with the urine.
Głuszek
J
J
Kliniki Nadciśnienia Tetniczego Instytutu Kardiologii AM im. K. Marcinkowskiego w Poznaniu.
Skołuda
A
A
Pupek-Musialik
D
D
D000328:Adult; D002118:Calcium / Q000652:urine*; D002927:Cimetidine / Q000008:administration & dosage*; D000242:Cyclic AMP / Q000652:urine*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008274:Magnesium / Q000652:urine*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010710:Phosphates / Q000652:urine*
D010710:Phosphates; D002927:Cimetidine; D000242:Cyclic AMP; D008274:Magnesium; D002118:Calcium
Wpływ dozylnego podania cymetydyny na nerkowe wydalanie wapnia, fosforanów, magnezu oraz cyklicznego adenozynomonofosforanu.