Focal cerebral dysfunction in developmental learning disabilities.
In 24 children with developmental learning disabilities and 15 age-matched controls regional cerebral activity was studied with xenon-133 single photon emission tomography. In the 9 children with pure attention deficit and hyperactivity disorder (ADHD), the distribution of regional cerebral activity was abnormal--low in striatal and posterior periventricular regions and high in occipital regions. Low activity in striatal and posterior periventricular areas was also seen in the 8 children with ADHD in combination with phonologic-syntactic dysphasia. 7 children with dysphasia, but without hyperactive behaviour, had low cerebral activity in left temporofrontal regions.
Lou
H C
HC
John F. Kennedy Institute, Glostrup, Denmark.
Henriksen
L
L
Bruhn
P
P
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002421:Caudate Nucleus / Q000098:blood supply / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D002648:Child; D003116:Color; D005069:Evaluation Studies as Topic; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D006801:Humans; D007806:Language Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007859:Learning Disabilities / Q000503:physiopathology; D008297:Male; D009778:Occipital Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D013702:Temporal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes