Inhibitory effect of a new antibiotic, guanine 7-N-oxide, on the replication of several RNA viruses.
Guanine 7-N-oxide (G-7-Ox) was examined for its antiviral activity against 9 viruses based on plaque reduction, neuraminidase activity reduction, a fluorescent antibody technique or ELISA. The following viruses were included in the tests: influenza, Sendai, simian virus 5 (SV5), respiratory syncytial, western equine encephalitis, Japanese encephalitis, vesicular stomatitis, rabies and polio. G-7-Ox showed broad anti-RNA viral activity against all viruses tested, except for poliovirus. Inhibition of persistent SV5 infection by G-7-Ox indicates that its antiviral activity is independent of cytotoxicity.
Yamamoto
K
K
Department of Virology & Rickettsiology, National Institute of Health, Tokyo, Japan.
Kitano
T
T
Arai
Y T
YT
Yoshii
K
K
Hasobe
M
M
Saneyoshi
M
M
D000818:Animals; D002460:Cell Line; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology; D009980:Influenza A virus / Q000187:drug effects; D009439:Neuraminidase / Q000378:metabolism; D010252:Paramyxoviridae / Q000187:drug effects; D017955:Poliovirus / Q000187:drug effects; D012328:RNA Viruses / Q000187:drug effects*; D012367:RNA, Viral / Q000096:biosynthesis; D012209:Rhabdoviridae / Q000187:drug effects; D014035:Togaviridae / Q000187:drug effects; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
D012367:RNA, Viral; C046075:guanine 7-oxide; D006147:Guanine; D009439:Neuraminidase