ACTH(1-24) stimulates the migration of human monocytes in vitro.
In view of the increasing evidence that a variety of stresses can influence immune responses, the direct effect of adrenocorticotropic hormone on the migration of human monocytes was studied in vitro. ACTH(1-24) significantly increased the number of migrating cells when placed in the same or the opposite compartment of the chemotaxis chamber, maximum activity being obtained at 10(-14) and 10(-8) M. The results indicate that ACTH(1-24) directly and potently stimulates the migration of human monocytes by means of a chemokinetic effect.
Genedani
S
S
Institute of Pharmacology, University of Modena, Italy.
Bernardi
M
M
Baldini
M G
MG
Bertolini
A
A
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000704:Analysis of Variance; D002465:Cell Movement / Q000187:drug effects; D003366:Cosyntropin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology
D003366:Cosyntropin; D009240:N-Formylmethionine Leucyl-Phenylalanine; D000324:Adrenocorticotropic Hormone