[A potentiometric rapid method of determining the level of phenylacetic acid during the production of beta-lactam antibiotics].
A potentiometric rapid method for control of phenylacetic acid (PAA) concentration in production of ++beta-lactam antibiotics is described. The method is based on ion selective electrodes with a film membrane. The results of the theoretical and experimental studies on estimation of the electrode selectivity specific of PAA in the presence of various interfering ions are presented. It was shown possible to use the electrodes for PAA control in the media containing nitrates, bicarbonates and chlorides. Recommendations how to use the ion selective electrodes at various stages in production of ++beta-lactam antibiotics are given. Prospects for improving the method and designing an instrument for rapid assay of phenyl acetate ion activity are discussed.
Pisarev
S V
SV
Itsygin
S V
SV
Bart
T Ia
TIa
Kozlov
V R
VR
D000395:Air Pollutants, Occupational / Q000302:isolation & purification* / Q000633:toxicity; D004566:Electrodes; D004867:Equipment Design; D006801:Humans; D007218:Industrial Microbiology / Q000379:methods* / Q000592:standards; D008452:Maximum Allowable Concentration; D009787:Occupational Medicine / Q000379:methods* / Q000592:standards; D010406:Penicillins / Q000096:biosynthesis*; D010648:Phenylacetates / Q000302:isolation & purification* / Q000633:toxicity; D011199:Potentiometry / Q000295:instrumentation / Q000379:methods; D014586:USSR
D000395:Air Pollutants, Occupational; D010406:Penicillins; D010648:Phenylacetates; C025136:phenylacetic acid
Potentsiometricheskiĭ ékspress-metod opredeleniia kontsentratsii feniluksusnoĭ kisloty pri poluchenii betalaktamnykh antibiotikov.