Variable association of HLA-A2 in men with early-onset Alzheimer disease.
In the present study, we attempted to replicate the finding of an increased frequency of HLA-A2 in men with early-onset (less than or equal to 60 years) Alzheimer disease (AD). HLA data obtained on 167 patients (including 19 men with early-onset AD) from three geographic regions (North Carolina, Great Britain, and Finland) failed to replicate the result. A recent prospective study from Oregon, however, confirmed the association. Studies demonstrating the association suggest its presence in sporadic rather than familial AD. These results indicate a variable HLA/AD association, with some factor such as geographic region or disease familiality contributing to this variability.
Small
G W
GW
UCLA Neuropsychiatric Institute, Los Angeles, CA 90024.
Ebeling
S C
SC
Matsuyama
S S
SS
Heyman
A
A
Reisner
E G
EG
Renvoize
E B
EB
Sulkava
R
R
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000276:immunology*; D005260:Female; D015789:HLA-A2 Antigen / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D015789:HLA-A2 Antigen