title: Cryptosporidiosis in patients with hematologic malignancies.
abstract: The clinical features of cryptosporidial infection in 20 patients with hematologic malignancies were assessed. Five patients had severe diarrhea, 10 had moderate diarrhea, and five were asymptomatic carriers of Cryptosporidium. Extraintestinal cryptosporidiosis with pulmonary involvement was observed in one case and relapse of cryptosporidiosis in four. All but one patient recovered from cryptosporidiosis whether or not spiramycin was administered. Cryptosporidiosis in T cell-depleted recipients of allogeneic bone marrow transplants did not appear more severe than that in patients undergoing autologous bone marrow transplantation or conventional chemotherapy.
authors.affiliation: Dipartimento di Biopatologia Umana, Università La Sapienza, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Gentile
authors.forename: M
authors.initials: M
authors.lastname: Venditti
authors.forename: A
authors.initials: A
authors.lastname: Micozzi
authors.forename: A
authors.initials: A
authors.lastname: Caprioli
authors.forename: G
authors.initials: G
authors.lastname: Donelli
authors.forename: C
authors.initials: C
authors.lastname: Tirindelli
authors.forename: G
authors.initials: G
authors.lastname: Meloni
authors.forename: W
authors.initials: W
authors.lastname: Arcese
authors.forename: P
authors.initials: P
authors.lastname: Martino
mesh_terms: D000293:Adolescent; D000328:Adult; D002353:Carrier State / Q000188:drug therapy; D002648:Child; D003457:Cryptosporidiosis / Q000188:drug therapy / Q000209:etiology*; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000209:etiology*; D007938:Leukemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications*; D015572:Spiramycin / Q000627:therapeutic use
chemical_list: D015572:Spiramycin