Physical mapping of the CD3 gene cluster.
By a combination of pulsed-field gel electrophoresis and molecular cloning techniques, the human CD3-gamma, CD3-delta and CD3-epsilon genes have been shown to be clustered in approximately 50 kb of chromosome 11q23. The mouse genes are probably organised in a similar fashion on chromosome 9. An approach to the construction of a long-range physical map surrounding the CD3 gene cluster is described, which will complement the genetic maps of the region.
Tunnacliffe
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Basel Institute for Immunology, Switzerland.
D000818:Animals; D015703:Antigens, CD / Q000235:genetics*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D017252:CD3 Complex; D002880:Chromosomes, Human, Pair 11; D003001:Cloning, Molecular; D004586:Electrophoresis; D005802:Genes, MHC Class II / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D051379:Mice; D005810:Multigene Family; D012150:Polymorphism, Restriction Fragment Length; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D015183:Restriction Mapping
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D005819:Genetic Markers; D011948:Receptors, Antigen, T-Cell