title: M-component with reactivity against actin associated with thrombotic thrombocytopenic purpura.
abstract: A patient with a monoclonal B-cell disorder producing an M-component with antiactin activity is described. After more than 3 years of observations, the final diagnosis is not completely established, but a malignant lymphoproliferative process is evidently under evolution. On three occasions, she has presented with symptoms compatible with a thrombotic thrombocytopenic purpura-like syndrome, concomitant with an increase in paraprotein. A relationship between this autoantibody and the patient's symptoms is proposed. Steroids have so far had a beneficial effect on the symptoms.
authors.affiliation: Department of Medicine Ostra Hospital, Gothenburg, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Bäck
authors.forename: G
authors.initials: G
authors.lastname: Nilsson
authors.forename: G K
authors.initials: GK
authors.lastname: Hansson
authors.forename: S
authors.initials: S
authors.lastname: Rödjer
authors.forename: A
authors.initials: A
authors.lastname: Tarkowski
mesh_terms: D000199:Actins / Q000276:immunology*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D010265:Paraproteinemias / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D010266:Paraproteins / Q000032:analysis* / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D000199:Actins; D010266:Paraproteins; D013629:Tamoxifen; D011241:Prednisone