title: [Cytogenetic study of peripheral lymphocyte culture in couples with habitual abortion].
abstract: We report on a cytogenetic investigation of lymphocytes in 241 couples and six women with at least three abortions. We found a balanced reciprocal translocation three times (1.2% of couples) and a balanced Robertsonian translocation twice (0.8% of couples). Four numerical aberrations of the gonosomes were detected (three of them as a mosaic), and one deletion Xq- as a mosaic. The heterochromatic region of the chromosomes 1, 9 or 16 was enlarged in 12 couples (4.9%). There was no couple with a pericentric inversion of the chromosomes 1 or 9. The enlarged Y-chromosome (five males) according to our results does not play any important role for the reproduction. Five translocations and one supernumerary chromosome each in one cell only indicate an enlarged frequency of breakage events in couples with habitual abortion.
authors.affiliation: Klinik und Poliklinik für Gynäkologie und Geburtshilfe, Medizinischen Akademie Carl Gustav Carus Dresden, Bundesrepublik Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Junge
authors.forename: N
authors.initials: N
authors.lastname: Domke
authors.forename: E
authors.initials: E
authors.lastname: Tolkendorf
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D002871:Chromosome Banding; D002872:Chromosome Deletion; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D014178:Translocation, Genetic
vernacular_title: Zygogenetische Untersuchung von peripheren Lymphozytenkulturen bei Paaren mit habituellen Aborten.