title: Halothane-sparing effect of benzodiazepines in ponies.
abstract: The halothane-sparing effect of 2 benzodiazepines, diazepam and temazepam, were investigated in ponies by measuring the minimum alveolar concentration (MAC) for halothane before and after drug administration. The MAC value for halothane decreased 29% and 16% when either 0.044 mg/kg of diazepam or 0.044 mg/kg of temazepam, respectively, was administered intravenously. Heart rate, respiratory rate, systolic and mean arterial blood pressure, and expired CO2 were also measured. No differences were present in these variables before and after drug administration nor were differences noted between the benzodiazepines.
authors.affiliation: Boren Veterinary Medical Teaching Hospital, Oklahoma State University, Stillwater 74078-0107.
authors.forename: N S
authors.initials: NS
authors.lastname: Matthews
authors.forename: N S
authors.initials: NS
authors.lastname: Dollar
authors.forename: R V
authors.initials: RV
authors.lastname: Shawley
mesh_terms: D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D006221:Halothane / Q000032:analysis / Q000493:pharmacokinetics*; D006339:Heart Rate / Q000187:drug effects; D006736:Horses / Q000378:metabolism / Q000502:physiology*; D008297:Male; D011175:Positive-Pressure Respiration / Q000662:veterinary; D011650:Pulmonary Alveoli / Q000032:analysis; D012119:Respiration / Q000187:drug effects; D013693:Temazepam / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D013693:Temazepam; D003975:Diazepam; D006221:Halothane