[The action of benzimidazole derivative preparations on the formation of DNA-protein cross-links in the UV irradiation of chromatin].
Effect of benzimidazole-derivatives on the DNA-protein binding formation was studied after UV-radiation of chromatin. These derivatives were shown to protect chromatin from UV-induced DNA-protein binding formation. Structural analog contained two aminomethyl residuals sensibilized additional binding formation in chromatin. Results suggested, that benzimidazole interacted with DNA, while aminomethyl groups interacted with protein and sensibilized binding of DNA with histone H1.
Mil'
E M
EM
Biniukov
V I
VI
Zhil'tsova
V M
VM
Stoliarova
L G
LG
Kuznetsov
Iu V
IuV
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D002417:Cattle; D002843:Chromatin / Q000378:metabolism / Q000528:radiation effects*; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D004347:Drug Interactions / Q000528:radiation effects; D006657:Histones / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D066298:In Vitro Techniques; D011485:Protein Binding / Q000187:drug effects / Q000528:radiation effects; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays
D001562:Benzimidazoles; D002843:Chromatin; D003432:Cross-Linking Reagents; D006657:Histones; D004247:DNA
Deĭstvie preparatov proizvodnykh benzimidazola na obrazovanie sshivok DNK--belok pri UF-obluchenii khromatina.