title: [Pharmacokinetic study of a new benzyl-1 isoquinoline derivative (458 L) after oral administration in men].
abstract: Pharmacokinetic study of 458 L. via oral route, was performed in twelve normal volunteers, in a randomized crossover design of three galenic forms. Plasma concentrations were determined, after extraction, by HPLC, with spectrofluorimetric detection. Plasmatic kinetics were fitted to a bi-exponential function with a distribution half-life of 1h and an elimination half-life of 11.5 to 14.7 h according to the form. Pharmacokinetic parameters evaluated as area under the curve (AUC), maximum plasma concentrations (Cmax), relative bioavailability (F'), have shown strong interindividual differences, specially in women group, and this with tobacco smoking.
authors.affiliation: Groupe de Recherche en Biodynamique du Médicament (ER), Faculté de Pharmacie, Clermont-Ferrand.
authors.forename: H
authors.initials: H
authors.lastname: Bargnoux
authors.forename: J P
authors.initials: JP
authors.lastname: Kantelip
authors.forename: M
authors.initials: M
authors.lastname: Bastide
authors.forename: P
authors.initials: P
authors.lastname: Duchêne-Marullaz
authors.forename: R
authors.initials: R
authors.lastname: Boyer
authors.forename: P
authors.initials: P
authors.lastname: Lallouette
authors.forename: J
authors.initials: J
authors.lastname: Petit
authors.forename: J A
authors.initials: JA
authors.lastname: Bérger
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007546:Isoquinolines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D044005:Tetrahydroisoquinolines
chemical_list: D006634:Histamine H1 Antagonists; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C030388:458L
vernacular_title: Etude pharmacocinétique d'un nouveau dérivé de la benzyl-1 isoquinoléine (458 L) après administration orale chez l'homme.