title: Stressor-induced alterations of natural killer cell activity and central catecholamines in mice.
abstract: Natural killer (NK) cell cytotoxicity was determined at various intervals (0.5, 24 or 48 h) following exposure to uncontrollable footshock in 3 strains of mice. Stressor application provoked reductions of NK activity, but the time course of the NK changes varied across strains. Whereas NK cytotoxicity was markedly reduced in C57BL/6J mice 0.5-48 h following stressor exposure, this effect was delayed in C3H/HeJ mice, being evident 24-48 h following stressor application. In BALB/cByJ mice, NK activity was significantly reduced 24 h after footshock, but in contrast to the other strains returned to control levels within 48 h of stressor exposure. Central NE and DA concentrations and activity were influenced by the stressor treatment in a strain-dependent fashion. However, the relationship between the central amine variations and the alterations of NK cytotoxicity associated with the stressor was limited.
authors.affiliation: Carleton University, Department of Psychology, Ottawa, Ontario.
authors.forename: S
authors.initials: S
authors.lastname: Zalcman
authors.forename: J
authors.initials: J
authors.lastname: Irwin
authors.forename: H
authors.initials: H
authors.lastname: Anisman
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D002395:Catecholamines / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002860:Chromium Radioisotopes; D004298:Dopamine / Q000378:metabolism; D004597:Electroshock; D007694:Killer Cells, Natural / Q000502:physiology*; D008125:Locus Coeruleus / Q000378:metabolism; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009638:Norepinephrine / Q000378:metabolism; D013045:Species Specificity; D013315:Stress, Psychological / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D002395:Catecholamines; D002860:Chromium Radioisotopes; D015102:3,4-Dihydroxyphenylacetic Acid; D008734:Methoxyhydroxyphenylglycol; D004298:Dopamine; D009638:Norepinephrine