[Determination of tetracyclines by flow injection analysis].
An accurate, convenient and fast method was proposed for the determination of tetracyclines (tetracycline, chlortetracycline, oxytetracycline, doxycycline and methacycline) and their preparations by flow injection detector based on tetracycline flow-through sensor. The parameters affecting the measurement were discussed. The detector can respond to tetracycline, chlortetracycline, oxytetracycline, doxycycline and methacycline, at the same time. Their slopes are 51-55 mV/decade over the concentration range of 10(-2)-5 x 10(-5) mol/L at pH 1.5-3.5. The results obtained are in good agreement with those by biological assay (less than 3% deviation). One hundred samples can be determined in an hour.
Liu
W Z
WZ
Hubei Provincial Institute for Drug Control, Wuhan.
Jiang
H
H
Du
A Z
AZ
D004563:Electrochemistry; D013754:Tetracyclines / Q000032:analysis*
D013754:Tetracyclines