[Biological characteristics of cachectin (TNF) and its potential role in therapy].
In the paper the possible physiological significance and pathological role of cachectin as a mediator of endotoxic shock and wasting in chronic diseases are reviewed. The influence of this monokine on normal haematopoietic cells and their leukaemic counterparts is presented. The effect of TNF on neoplastic cells in vitro and in vivo and its possible application in the treatment of cancer is also discussed.
Robak
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Pracownia Farmakologii Klinicznej Zakładu Farmakologii, Akademii Medycznej w Lodzi.
D000818:Animals; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D012772:Shock, Septic / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology* / Q000627:therapeutic use
D014409:Tumor Necrosis Factor-alpha
Właściwości biologiczne kachektyny (TNF) i jej potencjalna rola w terapii.