Variations in chemotaxis and chemokinesis of neutrophils of different densities from patients with allergic rhinitis.
We investigated chemotaxis and chemokinesis of neutrophils of different densities from normals and subjects with allergic rhinitis (AR). The chemotaxis of neutrophils with lower density was significantly increased compared with neutrophils with higher density in AR using fMLP (P less than .01) or PAF (P less than .05). In normal subjects, however, there was no significant difference in neutrophil chemotaxis of the two fractions. No significant difference was found in neutrophil chemokinesis of the two fractions from AR or normals. These results indicate that neutrophils with lower density from AR possess greater affinity to fMLP or PAF as compared with neutrophils with higher density and this may be relevant to the pathophysiology of AR.
Miyagawa
H
H
Allergic Disease Center, Creighton University, Omaha, Nebraska.
Okada
C
C
Sugiyama
H
H
Hopp
R J
RJ
Agrawal
D K
DK
Bewtra
A K
AK
Townley
R G
RG
D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte; D006801:Humans; D007958:Leukocyte Count; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000166:cytology* / Q000502:physiology; D010972:Platelet Activating Factor / Q000494:pharmacology; D012221:Rhinitis, Allergic, Perennial / Q000097:blood*; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood*
D010972:Platelet Activating Factor; D009240:N-Formylmethionine Leucyl-Phenylalanine