title: Inverse changes in erythroid cell volume and number regulate the hematocrit in newborn genetically hypertensive rats.
abstract: Erythrocytosis and microcytosis have been described in strains of genetically hypertensive rats and in essentially hypertensive humans. Published discussion of these phenomena has centered around their relationship to observed alterations in ionic transport and the pathogenesis of hypertension. In presenting data for another strain of spontaneously hypertensive rats in which these findings are exhibited, we note that erythroid cell size decreases concurrently with the increase in cell numbers so that the hematocrit and the mean corpuscular hemoglobin concentration remain constant. Data from the literature support the hypothesis that erythroid cell size is inversely proportional to cell count in a large number of species. Erythrocytosis, as it develops in the neonatal rat, is a consequence of the marked immaturity of this species at birth. Erythrocytosis in the spontaneously hypertensive rat is not due to a difference in the affinity of its hemoglobin for oxygen or to significant tissue anorexia. Microcytosis in the spontaneously hypertensive rat is the consequence of a continuation of the linear volume decrease with age of its erythroid cells seen in the normotensive animals and may be accounted for by the production of smaller cells with concomitant regulation of individual cell volume.
authors.affiliation: Department of Medicine, University of Connecticut School of Medicine, Farmington 06032.
authors.forename: J W
authors.initials: JW
authors.lastname: Boylan
authors.forename: J B
authors.initials: JB
authors.lastname: Van Liew
authors.forename: P U
authors.initials: PU
authors.lastname: Feig
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D004906:Erythrocyte Count; D004911:Erythrocyte Volume; D004912:Erythrocytes / Q000166:cytology*; D004920:Erythropoiesis; D006400:Hematocrit; D006454:Hemoglobins / Q000737:chemistry; D051381:Rats; D011918:Rats, Inbred SHR / Q000097:blood*; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY / Q000097:blood
chemical_list: D006454:Hemoglobins