title: Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): H-2 linked genes determine worm survival.
abstract: The course of primary infection was studied in BALB and B10 H-2 congenic mouse strains. The duration of infection, as assessed with regular faecal egg counts and worm burdens, was shorter in mice carrying the H-2s, H-2d or H-2q haplotypes when compared to mice with H-2b. Strains with H-2k were intermediate. An experiment was carried out to test the hypothesis proposed by Wassom, Krco & David (1987) predicting that the progeny of I-E+ve mouse strains crossed with I-E-ve strains, would show susceptibility rather than resistance to infection. This hypothesis was not substantiated by our data and we conclude that it does not apply to primary infections with Heligmosomoides polygyrus. It is proposed that the gene products of at least two loci within the H-2 (associated with the H-2b and H-2k haplotypes) are crucial in determining the response phenotype of mice to primary infection with H. polygyrus. One allele, (associated with the H-2b haplotype) may be preferentially affected by parasite-mediated immunosuppression.
authors.affiliation: MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham.
authors.forename: J M
authors.initials: JM
authors.lastname: Behnke
authors.forename: F N
authors.initials: FN
authors.lastname: Wahid
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D005243:Feces / Q000469:parasitology; D005260:Female; D005805:Genes, MHC Class I; D006239:Haplotypes; D007113:Immunity, Innate / Q000235:genetics; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009349:Nematode Infections / Q000235:genetics / Q000276:immunology*; D009351:Nematospiroides dubius / Q000276:immunology*; D010270:Parasite Egg Count