title: A refractory type asthmatic whose symptoms markedly improved by midaglizole.
abstract: We present a patient with refractory intrinsic asthma who showed a good response to both a single oral dose and a 4-week period of administration of the selective alpha-2 adrenoceptor antagonist, midaglizole. After the single dose, bronchodilation was immediately observed. With continuous administration, the peak expiratory flow rate (PEFR) was increased and the total daily intake of aerosol was decreased in a dose-dependent fashion. These results suggest that the addition of midaglizole to the usual antiasthmatic agents can be of value in the management of refractory asthma.
authors.affiliation: College of Medical Care and Technology, Gunma University, School of Medicine, Maebashi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakazawa
authors.forename: K
authors.initials: K
authors.lastname: Iizuka
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshie
mesh_terms: D000284:Administration, Oral; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D013997:Time Factors
chemical_list: D000317:Adrenergic alpha-Antagonists; D001993:Bronchodilator Agents; D007093:Imidazoles; C032368:midaglizole