Plasma and cerebrospinal fluid concentration of temazepam following oral drug administration.
Thirteen male patients were administered 20 mg of temazepam orally 1 to 2 h prior to undergoing spinal anaesthesia for a urological procedure. Samples of blood and CSF were drawn just before insertion of the spinal and the concentration of drug estimated in these two media. The results obtained indicated that a highly significant correlation existed between the unbound concentration of temazepam in plasma and the concentration of drug present in CSF. Temazepam appeared to be an effective light pre-medicant in all of the subjects studied.
Badcock
N R
NR
Department of Chemical Pathology, Adelaide Children's Hospital, South Australia.
Osborne
G A
GA
Nyman
T L
TL
Sansom
L N
LN
Russell
W J
WJ
Frewin
D B
DB
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics*; D001798:Blood Proteins / Q000378:metabolism; D002849:Chromatography, Gas; D003956:Dialysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D013693:Temazepam / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*
D014151:Anti-Anxiety Agents; D001798:Blood Proteins; D013693:Temazepam