Sigma receptor blockade by BMY 14802 affects enkephalinergic and tachykinin cells differentially in the striatum of the rat.
We determined proenkephalin and protachykinin mRNA levels in the striatum of the rat by in situ hybridization histochemistry in controls and in animals treated for 14 days with the potential neuroleptic drug BMY 14802 (15 mg/kg i.p.). Proenkephalin mRNA levels were increased relative to control values by 107, 88 and 94% and protachykinin mRNA levels decreased by 17, 28 and 10% in the rostral, medial and caudal aspects of the caudate-putamen, respectively. The data suggest that sigma receptor activity, directly or indirectly, affects proenkephalin and protachykinin mRNA expression in striatal neurons.
Angulo
J A
JA
Columbia University, College of Physicians and Surgeons, Department of Neurology, New York, NY.
Cadet
J L
JL
McEwen
B S
BS
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism; D004745:Enkephalins / Q000235:genetics; D008297:Male; D009292:Narcotic Antagonists; D009693:Nucleic Acid Hybridization; D011498:Protein Precursors / Q000235:genetics; D011743:Pyrimidines / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017465:Receptors, Opioid, delta; D015320:Tachykinins / Q000235:genetics
D014151:Anti-Anxiety Agents; D004745:Enkephalins; D009292:Narcotic Antagonists; D011498:Protein Precursors; D011743:Pyrimidines; D012333:RNA, Messenger; D017465:Receptors, Opioid, delta; D015320:Tachykinins; C029992:proenkephalin; C054618:protachykinin; C050408:alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol