title: Hypothesis: pathogenesis of postmenopausal hot flush.
abstract: The pathogenesis of postmenopausal hot flush is still poorly understood. A hypothesis is presented where the perimenopausal decline in circulating estrogen levels may increase central norepinephrine and LH-RH secretion and produce a downward setting of the central thermostat resulting in a hot flush.
authors.affiliation: Department 235, Hvidovre University Hospital, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Rosenberg
authors.forename: S H
authors.initials: SH
authors.lastname: Larsen
mesh_terms: D001833:Body Temperature Regulation; D002979:Climacteric / Q000502:physiology*; D004967:Estrogens / Q000097:blood / Q000502:physiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006801:Humans; D008593:Menopause / Q000502:physiology*; D008954:Models, Biological
chemical_list: D004967:Estrogens; D007987:Gonadotropin-Releasing Hormone