title: The concentration of dopamine and related monoamines in arteries and some other tissues of the sheep.
abstract: 1. The highest concentrations of dopamine were observed in the sheep coronary interventricular artery (1.0 micrograms/g) and the lowest in the aorta (0.15 micrograms/g). Varying proportions of noradrenaline was also present in the arteries examined with dopamine:noradrenaline ratios ranging from 0.08 to 1.11. 2. p-Tyramine is the trace amine present in highest concentration in both the lung and the caudate nucleus (21.3 and 10.5 ng/g, respectively) while the levels of beta-phenylethylamine, m-tyramine and tryptamine are lower and range between 1.6 and 4.2 ng/g. 3. The results show that sheep arteries, lung and duodenum contain considerable amount of dopamine that is presumably associated with chromaffin cells. It is most likely that these cells also contain 5-hydroxytryptamine while the localization of trace amines remains to be elucidated.
authors.affiliation: Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada.
authors.forename: A V
authors.initials: AV
authors.lastname: Juorio
authors.forename: P J
authors.initials: PJ
authors.lastname: Chedrese
mesh_terms: D000818:Animals; D001158:Arteries / Q000032:analysis*; D015306:Biogenic Monoamines / Q000032:analysis*; D001923:Brain Chemistry; D004298:Dopamine / Q000032:analysis*; D004386:Duodenum / Q000032:analysis; D005260:Female; D008168:Lung / Q000032:analysis; D009928:Organ Specificity; D012756:Sheep / Q000378:metabolism*
chemical_list: D015306:Biogenic Monoamines; D004298:Dopamine