title: Adaptive regulation of central serotonin receptors linked to phosphoinositide hydrolysis.
abstract: Central 5-HT2 and 5-HT1C receptors appear to be relatively resistant to up-regulation. 5-HT2 receptors are not upregulated after denervation of 5-HT neurons and chronic administration of antagonists elicits a paradoxical downregulation of both receptors. This article explores the possible explanations for these anomalous findings.
authors.affiliation: Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232.
authors.forename: E
authors.initials: E
authors.lastname: Sanders-Bush
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D015536:Down-Regulation / Q000502:physiology; D006801:Humans; D006868:Hydrolysis; D010716:Phosphatidylinositols / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000502:physiology*; D015854:Up-Regulation / Q000502:physiology
chemical_list: D010716:Phosphatidylinositols; D011985:Receptors, Serotonin