title: [Heparin therapy in embolic cerebral infarct. A retrospective study].
abstract: Heparin therapy in acute stroke is a controversial issue. It is uncertain, whether heparin has a therapeutic or preventive effect in the early phase of the stroke. From 1984-1989, 1095 patients with acute ischemic stroke were treated, 141 (12.9%) of whom received heparin within 3 days of stroke onset. The mean duration of heparin anticoagulation was 10 days. In 28 cases (20%), heparin was used as antithrombotic agent (25/28 patients suffered a basilar artery occlusion, of whom 22 died). In 113 cases (80%), heparin was used in embolic stroke to prevent recurrence (24% cardioembolic stroke, 54% arterio-arterial embolism, and 22% embolism of unknown etiology). The rate of recurrent stroke in the early phase was 13% with a persistent deficit in 5.3%. The results are comparable with those of other trials reported in the literature. Only 2 patients had an anticoagulation-related haemorrhage with clinical deterioration. Heparin anticoagulation in acute stroke is a low-risk therapy, but its preventive value has not yet been demonstrated.
authors.affiliation: Neurologische Klinik, Klinikums Minden.
authors.forename: I
authors.initials: I
authors.lastname: Kunze
authors.forename: J
authors.initials: J
authors.lastname: Glahn
authors.forename: O
authors.initials: O
authors.lastname: Busse
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy; D002543:Cerebral Hemorrhage / Q000097:blood / Q000139:chemically induced; D002544:Cerebral Infarction / Q000097:blood / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006493:Heparin / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D002542:Intracranial Embolism and Thrombosis / Q000097:blood / Q000188:drug therapy*; D002546:Ischemic Attack, Transient / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D012008:Recurrence; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D006493:Heparin
vernacular_title: Heparintherapie bei embolischen, zerebralen Insulten. Eine retrospektive Untersuchung.