title: Angioscopic assessment of fibrinolysis for impending in situ saphenous vein graft thrombosis.
abstract: A failing femorotibial in situ saphenous vein bypass graft was found by angioscopic examination to be lined with white thrombus and was successfully treated by intraoperative lytic therapy rather than by thrombectomy with a balloon catheter. The platelet-fibrin debris was completely cleared by 250,000 units of urokinase. There were no bleeding complications and the potential for mechanical damage to the venous endothelium was prevented. The in vivo angioscopic observations of fibrinolysis are described.
authors.affiliation: Department of Surgery, University of Arizona Health Sciences Center, Tucson.
authors.forename: F N
authors.initials: FN
authors.lastname: Parent
authors.forename: V M
authors.initials: VM
authors.lastname: Bernhard
authors.forename: T S
authors.initials: TS
authors.lastname: Pabst
authors.forename: J J
authors.initials: JJ
authors.lastname: Piotrowski
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical; D005260:Female; D006083:Graft Occlusion, Vascular / Q000175:diagnosis / Q000517:prevention & control*; D006801:Humans; D007430:Intraoperative Care; D012501:Saphenous Vein / Q000601:surgery*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000175:diagnosis / Q000517:prevention & control*; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D014568:Urokinase-Type Plasminogen Activator