title: Incidence of multi-resistant gram-negative isolates in eight Dutch hospitals. The 1990 Dutch Surveillance Study.
abstract: Results from 8 Dutch hospitals participating in an international epidemiological surveillance project were analyzed to establish the prevalence of resistant Gram-negative species and to demonstrate the extent of cross-resistance. Overall resistance rates among the 828 isolates tested were lowest with imipenem, ciprofloxacin, amikacin, and tobramycin. Pseudomonas aeruginosa isolates exhibited a significant rate of resistance to broad-spectrum beta-lactam antibiotics. Among inducible enteric species, cross-resistance to cephalosporins, penicillins, and monobactams but not to imipenem was prevalent. The addition of clavulanic acid was not found to fully restore the susceptibility of beta-lactam-resistant Escherichia coli isolates and combined cephalosporin and penicillin resistance was also observed in these strains. These data indicated a high though unevenly distributed incidence of resistance and cross-resistance among Gram-negative isolates despite the conservative approach to antibiotic treatment traditionally followed in The Netherlands.
authors.affiliation: Merck Sharp & Dohme, Haarlem, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Buirma
authors.forename: A M
authors.initials: AM
authors.lastname: Horrevorts
authors.forename: J H
authors.initials: JH
authors.lastname: Wagenvoort
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D015994:Incidence; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence
chemical_list: D000900:Anti-Bacterial Agents