[Immunologic characterization of alpha-bungarotoxin binding proteins in human microcellular lung carcinoma].
Alpha Bungarotoxin, neurotoxin of long chain, is used very often as a tool for studying of muscular nicotinic acetylcholine receptors. It was found out that six human small-cell carcinoma cell lines tested had alpha Bungarotoxin binding sites. Using monoclonal and polyclonal antibodies alpha Bungarotoxin binding sites were found more similar to neuronal nicotinic receptors than to muscular nicotinic receptors. Hyperpolarization effect of alpha Bungarotoxin on small cell lung cancer cells could not be explained by the presence of ionic channels.
Huković
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Klinika za nespecificna plućna oboljenja, Podhrastovi, Sarajevo.
D000906:Antibodies; D000911:Antibodies, Monoclonal; D002038:Bungarotoxins; D018288:Carcinoma, Small Cell / Q000378:metabolism*; D002460:Cell Line; D002528:Cerebellar Neoplasms / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008527:Medulloblastoma / Q000378:metabolism; D009447:Neuroblastoma / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000276:immunology / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000276:immunology / Q000378:metabolism; D064569:alpha7 Nicotinic Acetylcholine Receptor
D000906:Antibodies; D000911:Antibodies, Monoclonal; D002038:Bungarotoxins; C579167:Chrna7 protein, human; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor
Imunoloska karakterizacija alfa bungarotoksin vezajućeg proteina na humanim stanicama mikrocelularnog karcinoma pluća.