[The mechanisms of the changes in the erythrocyte oxygen-transport function of patients with chronic kidney failure undergoing treatment by systematic hemodialysis].
Utilization by red blood cells of macroergic phosphates during cell incubation in polyionic medium was investigated in 15 healthy subjects and 20 glomerulonephritis patients on programmed hemodialysis for terminal chronic renal failure. By anemia severity the patients were divided into 2 groups. In less severe anemia there was more active utilization in glycolysis of 2,3-DPG and ATR in the presence of manifest oxidation of intraerythrocytic medium typical for Root effect predominance. This indicates that erythrocytic involvement into tissue oxygenation appears inadequate to high levels of macroergic phosphates. Hemodialysis in such patients promotes stabilization of red blood cell metabolism and Root effect suppression, thus contributing to maintenance of blood oxygen transport. In more severe anemia hemodialysis fails to establish biochemical grounds for improving erythrocytic gas transport function. The pattern of hemoglycolysis changes registered in cell incubation urge introduction of drugs stabilizing erythrocytic metabolism in the treatment of chronic renal failure.
Iudanova
L S
LS
Zakharova
N B
NB
Iakovleva
E V
EV
D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D001692:Biological Transport; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D010100:Oxygen / Q000097:blood*; D006435:Renal Dialysis
D004163:Diphosphoglyceric Acids; D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate; D010100:Oxygen
Mekhanizmy izmeneniia kislorodtransportnoĭ funktsii éritrotsitov u bol'nykh s khronicheskoĭ pochechnoĭ nedostatochnost'iu, nakhodiashchikhsia na lechenii sistematicheskim gemodializom.