Synthesis of C-(beta-D-glycosyl) analogues of 3-deoxy-D-manno-2-octulosonic acid (Kdo) as potential inhibitors of CMP-Kdo synthetase.
Eight C-(beta-D-glycosyl) analogues (14-21) of Kdo (3-deoxy-D-manno-2-octulosonic acid) were obtained from isopropylidene-protected ester precursors and tested in vitro for their inhibitory activity on CMP-Kdo synthetase. None had more than minor inhibitory activity.
Wåglund
T
T
Department of Organic Pharmaceutical Chemistry, University of Uppsala, Sweden.
Luthman
K
K
Orbe
M
M
Claesson
A
A
D002236:Carbohydrate Conformation; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D015394:Molecular Structure; D009713:Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D013400:Sugar Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D013400:Sugar Acids; C002532:2-keto-3-deoxyoctonate; D009713:Nucleotidyltransferases; C028984:3-deoxy-manno-octulosonate cytidyltransferase