title: Open noncontrolled multicenter long-term trial with ciclosporin in endogenous non-infectious uveitis.
abstract: The efficacy, tolerability and safety of low doses (5-7 mg/kg/day) of oral ciclosporin (CS) for treatment of endogenous uveitis resistant to conventional therapy were studied in an open, noncontrolled, multicenter long-term trial. CS was shown to be effective for patients with posterior or intermediate noninfectious uveitis; it limited the progression of the disease, decreased the number and severity of inflammatory relapses, and improved visual acuity while reducing signs of intraocular inflammation. Moreover, in corticodependent patients, a steroid-sparing effect was also obtained. At low doses and by means of the careful monitoring of safety parameters, the side effects (especially renal function impairment) were well controlled. Efficacy was maintained during long-term treatment.
authors.affiliation: Department of Ophthalmology, University of Padova, Italy.
authors.forename: A G
authors.initials: AG
authors.lastname: Secchi
authors.forename: C
authors.initials: C
authors.lastname: De Rosa
authors.forename: P
authors.initials: P
authors.lastname: Pivetti-Pezzi
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: V
authors.initials: V
authors.lastname: De Molfetta
authors.forename: S
authors.initials: S
authors.lastname: Tognon
authors.forename: L
authors.initials: L
authors.lastname: Latanza
authors.forename: G
authors.initials: G
authors.lastname: Catarinelli
authors.forename: R
authors.initials: R
authors.lastname: Scorrano
authors.forename: G
authors.initials: G
authors.lastname: Bragliani
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D014605:Uveitis / Q000188:drug therapy*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D016572:Cyclosporine; D003404:Creatinine