Screening of bone marrow and kidney transplant donors and recipients for cytomegalovirus antibody by commercial latex agglutination or competitive enzyme-linked immunosorbent assays.
A commercial competitive enzyme-linked immunosorbent assay and a sensitive in-house radioimmunosorbent test detected cytomegalovirus (CMV) antibody in similar numbers of serum specimens (66 and 67 of 152, respectively) obtained from bone marrow and renal transplant donors and recipients. In contrast a commercial latex agglutination assay for CMV antibody apparently gave false positive results when testing serum specimens obtained from organ donors. The implications for CMV screening of organ transplant donors and recipients are discussed.
Morris
D J
DJ
North Manchester Regional Virus Laboratory, Department of Pathological Sciences, University of Manchester, U.K.
Klapper
P E
PE
Crosdale
E
E
White
J
J
D000914:Antibodies, Viral / Q000032:analysis*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D007841:Latex Fixation Tests; D012680:Sensitivity and Specificity
D000914:Antibodies, Viral