title: [Neolignans from Piper polysyphorum C.DC].
abstract: Piper polysyphorum C.DC (Piperaceae) is indigenous to the southern part of China. In the course of screening for inhibitors of platelet activating factor (PAF), the nonpolar fraction was found to exhibit PAF inhibitory activity. One new neclignan named polysyphorin and three new enantiomeric forms of (+)-virolongin, (+)-grandisin and (+)-lancifolin D were isolated. Two known neolignans, wallichinine and hancinone D were also obtained from the same sources. The structure determination was based upon spectroscopic analysis (UV, IR, CD, MS, 1HNMR, 13CNMR, COSY) and derivative preparation. The structure for polysyphorin was established as threo-delta 7'-7-hydroxy-3,4,5,3',5'-pentamethoxy-8-O-4' -neolignan. It is a racemic enantiomer. The PAF inhibitory activities were reported.
authors.affiliation: School of Pharmaceutical Sciences, Beijing Medical University.
authors.forename: Y
authors.initials: Y
authors.lastname: Ma
authors.forename: G Q
authors.initials: GQ
authors.lastname: Han
authors.forename: C L
authors.initials: CL
authors.lastname: Li
authors.forename: J R
authors.initials: JR
authors.lastname: Cheng
authors.forename: B H
authors.initials: BH
authors.lastname: Arison
authors.forename: S B
authors.initials: SB
authors.lastname: Hwang
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D008031:Lignin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000031:analogs & derivatives; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors; D013237:Stereoisomerism
chemical_list: D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; C071829:polysyphorin; D008031:Lignin