title: Urticaria pigmentosa: an anesthetic challenge.
abstract: Urticaria pigmentosa is the most common form of mastocytosis, a disease in which abnormal proliferations of mast cells occur in various organs of the body. Multiple stimuli, including many drugs commonly used in anesthetic practice, can provoke mast cell degranulation and result in intraoperative hemodynamic instability. An anesthetic plan minimizing histamine release and utilizing vecuronium as the muscle relaxant is discussed, and the literature pertaining to urticaria pigmentosa is reviewed.
authors.affiliation: McNeil Center for Research in Anesthesia, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: E P
authors.initials: EP
authors.lastname: Greenblatt
authors.forename: L
authors.initials: L
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000758:Anesthesia; D002675:Child, Preschool; D005260:Female; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D014582:Urticaria Pigmentosa / Q000188:drug therapy / Q000503:physiopathology; D014673:Vecuronium Bromide / Q000627:therapeutic use
chemical_list: D006633:Histamine Antagonists; D014673:Vecuronium Bromide