Edinburgh trial of screening for breast cancer: mortality at seven years.
Between 1979 and 1981, 45,130 women in Edinburgh aged 45-64 were entered into a randomised trial of breast cancer screening by mammography and clinical examination. The initial attendance rate was 61% but this varied according to age and socioeconomic status and decreased over succeeding years. The cancer detection rate was 6.2 per 1000 women attending at the first visit; the rate fell to around 3 per 1000 in the years when mammography was routinely repeated and to around 1 per 1000 at the intervening visits with clinical examination alone as the screening method. After 7 years of follow-up the mortality reduction achieved was 17% (relative risk = 0.83, 95% CI 0.58-1.18), which was not statistically significant, even when corrected for socioeconomic status. In women aged 50 years and over a mortality reduction of 20% was achieved.
Roberts
M M
MM
Edinburgh Breast Screening Centre, University of Edinburgh, UK.
Alexander
F E
FE
Anderson
T J
TJ
Chetty
U
U
Donnan
P T
PT
Forrest
P
P
Hepburn
W
W
Huggins
A
A
Kirkpatrick
A E
AE
Lamb
J
J
D000367:Age Factors; D001943:Breast Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D002277:Carcinoma / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006266:Health Education; D006801:Humans; D008327:Mammography; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009367:Neoplasm Staging; D010808:Physical Examination; D011237:Predictive Value of Tests; D012042:Registries; D012606:Scotland / Q000453:epidemiology; D012959:Socioeconomic Factors; D013029:Space-Time Clustering