Antibodies to cerebellar soluble lectin CSL in multiple sclerosis.
Cerebrospinal fluid samples from 239 patients with various neurological disorders were tested for the presence of autoantibodies to an endogenous mannose-binding protein, the cerebellar soluble lectin CSL, by means of an immunoblotting test with rat CSL as antigen. 47 of 51 patients with multiple sclerosis were positive for anti-CSL compared with 30 of 188 patients with other neurological disorders. 14 of the 30 false-positive patients were over 60 years old, an age group not typical of multiple sclerosis patients. The specificity of the test for multiple sclerosis was 85% and the sensitivity 93.5%. The possibility that CSL is an important immunological target in multiple sclerosis allows new insights into the possible causes and development of this disorder.
Zanetta
J P
JP
Centre de Neurochimie du CNRS, Strasbourg, France.
Warter
J M
JM
Kuchler
S
S
Marschal
P
P
Rumbach
L
L
Lehmann
S
S
Tranchant
C
C
Reeber
A
A
Vincendon
G
G
D000328:Adult; D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D005069:Evaluation Studies as Topic; D005189:False Positive Reactions; D006801:Humans; D015151:Immunoblotting / Q000379:methods; D037102:Lectins / Q000276:immunology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology*; D011237:Predictive Value of Tests
D001323:Autoantibodies; D037102:Lectins; C059525:cerebellar soluble lectin