[Regrouping of peptide chains in molecules and molecular complexes: recognition and spatial conjugation codes of amino acids].
A two-step model for reactions between peptide and protein molecules in aqueous medium is considered. The first stage of the reaction involves specific recognition and primary complex formation. This process is governed by the amino acid interaction code a-a as a part of genetic code (algorithm a-n-n-a, amino acid-codon-anticodon-anti-amino acid). According to the a-a code, the primary complex formation is determined by amino acid pairs of opposite polarity. During the second stage of the reaction, when the contacting ligand and receptor surfaces undergo dehydration, the primary complex becomes rearranged. The new structure is mainly determined by pairwise contacts of amino acids having similar polarity and belonging to the same amino acid family.
Chipens
G I
GI
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D001483:Base Sequence; D008024:Ligands; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation
D000596:Amino Acids; D008024:Ligands; D010455:Peptides
Peregruppirovka peptidnykh tsepeĭ molekul i molkuliarnykh kompleksov: kod uznavaniia i kod prostranstvennoĭ sopriazhennosti aminokislot.