title: Differential effect of restraint stress on MHC class II expression by murine peritoneal macrophages.
abstract: The effect of restraint stress on the expression of MHC class II glycoproteins by peritoneal macrophages was evaluated. Restraint suppressed the expression of I-A by macrophages from mice that are susceptible to Mycobacterial infection. In contrast, restraint did not affect I-A expression by macrophages from resistant mice. The suppression of MHC class II expression required at least 8 h of restraint and recovered within 4 h after stress. The amount of restraint necessary to suppress I-A expression also resulted in higher levels of plasma corticosterone. Changes in I-A expression were under circadian rhythm control. The differences in the effect of restraint stress on expression of I-A by peritoneal macrophages from resistant and susceptible mice may, in part, be due to differences in the effect of corticosterone in MHC class II expression.
authors.affiliation: Department of Microbiology, Ohio State University, Columbus 43210.
authors.forename: B S
authors.initials: BS
authors.lastname: Zwilling
authors.forename: D
authors.initials: D
authors.lastname: Brown
authors.forename: R
authors.initials: R
authors.lastname: Christner
authors.forename: M
authors.initials: M
authors.lastname: Faris
authors.forename: M
authors.initials: M
authors.lastname: Hilburger
authors.forename: M
authors.initials: M
authors.lastname: McPeek
authors.forename: C
authors.initials: C
authors.lastname: Van Epps
authors.forename: B A
authors.initials: BA
authors.lastname: Hartlaub
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D003345:Corticosterone / Q000097:blood; D005508:Food Deprivation; D005786:Gene Expression Regulation; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis*; D007114:Immunization; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology; D010529:Peritoneal Cavity; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000209:etiology / Q000276:immunology*; D014868:Water Deprivation
chemical_list: D000949:Histocompatibility Antigens Class II; D003345:Corticosterone