[The effect of GABA-ergic agents on the development of a neurogenic stomach lesion in rats].
Neurogenic gastric lesions in rats were induced by combination of immobilization with 3-h long electrostimulation. After this stress a distinct decrease of noradrenalin and creatine phosphate content and then the activation of lipid peroxidation (LPO) in the stomach tissue was recorded. If the stress treatment was preceded by application of piracetam and fenibute, gastric tissue trophic was protected by way of prevention from a decrease of the content of noradrenalin, creatine phosphate and the activation of LPO.
Bul'on
V V
VV
Zavodskaia
I S
IS
Khnychenko
L K
LK
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation / Q000379:methods; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010889:Piracetam / Q000627:therapeutic use*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D013272:Stomach Diseases / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D014149:Tranquilizing Agents / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D011963:Receptors, GABA-A; D014149:Tranquilizing Agents; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid; D010889:Piracetam
Vliianie GAMK-ergicheskikh sredstv na razvitie neĭrogennogo povrezhdeniia zheludka krys.