5-HT3 receptor antagonists attenuate dopamine-induced hyperactivity in the rat.
The 5-HT3 receptor antagonists, ICS205-930, granisetron and zacopride, at low doses, inhibited the hyperactivity caused by a 13 day mesolimbic dopamine infusion in the rat. The antagonism decreased with the use of higher doses of the 5-HT3 receptor antagonists. The ability of low doses of the 5-HT3 receptor antagonists to inhibit dopamine-induced behavioural changes is similar to the inhibitory profile of known antipsychotic agents. It is suggested that 5-HT3 receptor antagonists may represent a new class of atypical antipsychotic agents.
Costall
B
B
Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, West Yorkshire, U.K.
Domeney
A M
AM
Naylor
R J
RJ
D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology; D018492:Dopamine Antagonists; D005260:Female; D017829:Granisetron; D007191:Indazoles / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D007267:Injections; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000494:pharmacology; D000077526:Tropisetron
D001549:Benzamides; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004298:Dopamine; D018492:Dopamine Antagonists; D017829:Granisetron; D007191:Indazoles; D007211:Indoles; D012702:Serotonin Antagonists; D000077526:Tropisetron; C055971:zacopride