title: Activated but not resting T cells or thymocytes express colony-stimulating factor 1 mRNA without co-expressing c-fms mRNA.
abstract: Following the observation that, besides acute myeloid leukemia cells, acute lymphoid leukemia cells of either B or T phenotype could express the transcript for the colony-stimulating factor 1 (CSF-1), a growth factor known to be restricted to the monocytic-macrophage lineage, various sources of resting and/or activated T cells and thymocytes were screened for expression of this hemopoietic growth factor. We report here that the CSF-1 transcript was rapidly (7 h) induced in T cells by a variety of stimuli, but was not detectable in either resting T cells or thymocytes. In addition, secretion of CSF-1 was detectable in the supernatants of activated T cells by 72 h, with a peak around 92-120 h. In contrast to activated monocytes, the transcript of the c-fms proto-oncogene, the product of which is the receptor for CSF-1, was not detectable in either resting or activated T cells. This observation could be relevant to the intimate relationships between T cells and antigen-presenting cells during immune responses.
authors.affiliation: Unité 119 de l'INSERM, Institut Paoli-Calmettes, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Cerdan
authors.forename: M
authors.initials: M
authors.lastname: Courcoul
authors.forename: D
authors.initials: D
authors.lastname: Razanajaona
authors.forename: A
authors.initials: A
authors.lastname: Pierrès
authors.forename: N
authors.initials: N
authors.lastname: Maroc
authors.forename: M
authors.initials: M
authors.lastname: Lopez
authors.forename: P
authors.initials: P
authors.lastname: Mannoni
authors.forename: C
authors.initials: C
authors.lastname: Mawas
authors.forename: D
authors.initials: D
authors.lastname: Olive
authors.forename: F
authors.initials: F
authors.lastname: Birg
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015152:Blotting, Northern; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D016827:CD8 Antigens; D003115:Colony-Stimulating Factors / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D008213:Lymphocyte Activation; D016173:Macrophage Colony-Stimulating Factor; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D016186:Receptor, Macrophage Colony-Stimulating Factor; D011956:Receptors, Cell Surface / Q000235:genetics; D013601:T-Lymphocytes / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology / Q000502:physiology*; D013997:Time Factors
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D003115:Colony-Stimulating Factors; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D016173:Macrophage Colony-Stimulating Factor; D016186:Receptor, Macrophage Colony-Stimulating Factor