Cell-cell association in ascites Dalton's lymphoma and the effect of cisplatin in vivo.
Scanning electron microscopic studies revealed that ascites Dalton's lymphoma cells are distributed singly (25-30%) or in groups of 2-3 cells (55-60%) and 5 or more cells (10-15%) connected together. The percentage of single cells and groups of 2-3 or more cells changes with tumor growth. The number of single cells is maximal 72 h after tumor transplantation. Control tumor cells revealed the presence of blebs--ruffles all over the cells. Cisplatin treatment of the cells in vivo brings about definite changes in the arrangement of blebs--ruffles over the cells. At the later stages of cisplatin treatment disintegration and breaking of the plasma membrane occurs, which ultimately results in the lysis of tumor cells.
Prasad
S B
SB
Department of Zoology, North Eastern Hill University, Shillong, India.
Arjun
J
J
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology* / Q000648:ultrastructure; D002450:Cell Communication / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology*; D005260:Female; D007365:Intercellular Junctions / Q000187:drug effects*; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008855:Microscopy, Electron, Scanning; D014407:Tumor Cells, Cultured
D002945:Cisplatin