Systemic effects of carteolol, a beta-adrenoceptor antagonist in stroke-prone spontaneously hypertensive rats.
The preventive effects of carteolol, a beta-adrenoceptor antagonist, on secondary lesions were pathophysiologically examined in stroke-prone spontaneously hypertensive rats (SHRSP) from 8 to 30 weeks of age. Carteolol was added to the drinking water in doses of 0.005% (8 to 18 weeks of age) to 0.01% (19 to 30 weeks of age) (3.8 and 6.0 mg/kg/d, respectively). These animals gained significantly more weight than the untreated control SHRSP, and their heart rate reduced from 14 weeks of age. Suppression of blood pressure rise was not definite, however, histology revealed prevention of the development or aggravation of secondary hypertension-related lesions, such as myocardial fibrosis, proliferative arteriolitis, necrotic arteriolitis and renal glomerular lesions. A decrease in non-esterified fatty acids in the serum was evident. Thus, carteolol has cardiac as well as renal protective effects, in the SHRSP.
Yamashita
K
K
Department of Pharmacology 2, Nagasaki University School of Medicine, Japan.
Ohta
H
H
Uchida
S
S
Shigematsu
K
K
Ohkubo
T
T
Niwa
M
M
Ozaki
M
M
D000311:Adrenal Glands / Q000473:pathology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology; D001794:Blood Pressure / Q000187:drug effects*; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000473:pathology; D002354:Carteolol / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D008643:Mesentery / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013154:Spleen / Q000473:pathology; D014280:Triglycerides / Q000097:blood
D000319:Adrenergic beta-Antagonists; D005230:Fatty Acids, Nonesterified; D011412:Propanolamines; D014280:Triglycerides; D002354:Carteolol