[Effects of tetrahydroprotoberberines on dopamine release and 3,4-dihydroxyphenylacetic acid level in corpus striatum measured by in vivo voltammetry].
The extracellular (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum were measured by in vivo voltammetry to elucidate the effects of 3 tetrahydroprotoberberines on DA neurotransmission. l-tetrahydropalmatine (l-THP, 2 mg.kg-1) or l-stepholidine (l-SPD, 0.5 mg.kg-1) iv increased the striatal DA release by 225% and 233%, respectively; and l-SPD increased the DOPAC level by 70%. Moreover, the enantiomer d-THP (2 mg.kg-1) increased the DA release by 97%, and a large dose of d-THP (20 mg.kg-1) dramatically increased the extracellular DA by 1456% while it slightly elevated the DOPAC level by 123%. These results support the previous ideas that l-SPD and l-THP can block DA receptors and d-THP can deplete neuronal DA.
Huang
K X
KX
Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Sun
B C
BC
Gonon
F G
FG
Jin
G Z
GZ
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001599:Berberine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001600:Berberine Alkaloids / Q000494:pharmacology*; D002121:Calcium Channel Blockers; D002421:Caudate Nucleus / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D008839:Microelectrodes; D011048:Polarography; D051381:Rats; D013237:Stereoisomerism
D000470:Alkaloids; D001600:Berberine Alkaloids; D002121:Calcium Channel Blockers; D001599:Berberine; C010513:stepholidine; D015102:3,4-Dihydroxyphenylacetic Acid; C014215:tetrahydropalmatine; D004298:Dopamine