Fluorescent light decreases autoimmunity and improves immunity in B/W mice.
Fluorescent light emitted from cool white tubular fluorescent lamps covered with standard acrylic lids decreased autoimmunity and enhanced immunity in the New Zealand Black/New Zealand White F1 hybrid female (B/W) mouse model of systemic lupus erythematosus (SLE). Thirty-three weeks of daily cool white fluorescent light exposure significantly decreased anti-ds DNA antibody levels and spleen size, and increased lymphocyte responsiveness to lipopolysaccharide (LPS) in B/W mice depilated to enhance light penetration. Depilation alone had no significant effect. The immunomodulatory potential of fluorescent light in B/W mice has not been previously appreciated, and may have important implications in SLE.
McGrath
H
H
Department of Medicine, Louisiana State University School of Medicine, New Orleans.
Bak
E
E
Zimny
M L
ML
Michalski
J P
JP
D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D015551:Autoimmunity / Q000528:radiation effects*; D004195:Disease Models, Animal; D005260:Female; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008213:Lymphocyte Activation / Q000528:radiation effects*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D013154:Spleen / Q000276:immunology; D014466:Ultraviolet Rays
D000974:Antibodies, Antinuclear