title: [Effects of acetazolamide (Diamox, Glaupax) on tear production].
abstract: In view of personal clinical observations, it appeared possible that a therapy with the carboanhydrase inhibitor acetazolamide leads to a reduction of tear production and induces a dry eye syndrome. Tear secretion was therefore measured by Schirmer tests in a control group of 66 patients after cataract surgery and in a test group of 20 patients who were treated with acetazolamide (Diamox, Glaupax) on the day after the cataract operation. The results were subjected to a statistical analysis with 3-factor anova. The cataract operation induced a significant increase of tear flow. Independent of this effect, administration of the carboanhydrase inhibitor caused a significant decrease of tear production, both in the operated eyes and the untouched fellow eyes.
authors.affiliation: Abteilung für Mikrochirurgie des Auges, Universität Bonn.
authors.forename: K
authors.initials: K
authors.lastname: Rohrschneider
authors.forename: H R
authors.initials: HR
authors.lastname: Koch
mesh_terms: D000086:Acetazolamide / Q000008:administration & dosage / Q000009:adverse effects*; D000368:Aged; D002387:Cataract Extraction; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology; D008297:Male; D009798:Ocular Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D011183:Postoperative Complications / Q000188:drug therapy* / Q000503:physiopathology; D012016:Reference Values; D012636:Secretory Rate / Q000187:drug effects / Q000502:physiology; D013666:Tears / Q000187:drug effects* / Q000502:physiology
chemical_list: D000086:Acetazolamide
vernacular_title: Auswirkungen von Acetazolamid (Diamox, Glaupax) auf die Tränenproduktion.