title: [Modification of tear film break-up time by beta blocker eyedrops without preservatives].
abstract: Traditional beta-blocking eye drops preserved with benzalkonium chloride show an adverse effect on the precorneal tear film, which can be measured by checking the break-up-time (BUT). To decide, whether this adverse effect is caused more by the beta-blocking drug or the preservative, we tested the influence of timolol eye drops without preservative in single dose units Timosine) on the BUT in a prospective, open study. These eyedrops caused no significant shortening of the BUT in persons, which where untreated before. Patients using preserved beta-blocking eye drops and having irritations of their eyes showed significant prolongation of the BUT after changing the therapy to Timosine. Preservative-free beta-blocking eye drops are a real improvement in the therapy of glaucoma patients with irritated eyes.
authors.affiliation: Universitäts-Augenklinik Ulm.
authors.forename: R
authors.initials: R
authors.lastname: Marquardt
authors.forename: T
authors.initials: T
authors.lastname: Schubert
mesh_terms: D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D009798:Ocular Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects; D013666:Tears / Q000187:drug effects* / Q000502:physiology; D013999:Timolol / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical; D013999:Timolol
vernacular_title: Beeinflussung der Tränenfilmaufreisszeit (BUT) durch Betablocker-Augentropfen ohne Konservierungsstoffe.