Retardation of angiographic progression of coronary artery disease by nifedipine. Results of the International Nifedipine Trial on Antiatherosclerotic Therapy (INTACT). INTACT Group Investigators.
425 patients showing mild coronary artery disease (CAD) on arteriography were enrolled in a multicentre trial and randomised to treatment with nifedipine (80 mg/day) or placebo. The two groups were well matched for age, sex, and risk factors. 348 patients (82%) underwent repeat arteriography 3 years later; 282 (134 nifedipine, 148 placebo) had received treatment throughout, but treatment had been stopped in 39 nifedipine-treated and 27 placebo-treated patients after average periods of 354 and 467 days. Computer-assisted measurements of arteriograms from all restudied patients (175 placebo, 173 nifedipine) showed no significant differences in the number or severity of lesions on initial arteriograms, or in the progression or regression of existing lesions over 3 years. In contrast, the number of new lesions per patient was significantly lower in the nifedipine group than in the placebo group (0.59 vs 0.82 lesions per patient, a 28% reduction). Thus in patients with mild CAD nifedipine substantially suppresses disease progression as shown by the appearance of new lesions detectable by quantitative coronary arteriography.
Lichtlen
P R
PR
Division of Cardiology, Hannover Medical School, Federal Republic of Germany.
Hugenholtz
P G
PG
Rafflenbeul
W
W
Hecker
H
H
Jost
S
S
Deckers
J W
JW
D000284:Administration, Oral; D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000517:prevention & control*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005500:Follow-Up Studies; D006801:Humans; D015337:Multicenter Studies as Topic; D009543:Nifedipine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D010349:Patient Compliance; D011857:Radiographic Image Interpretation, Computer-Assisted; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012494:Sampling Studies
D009543:Nifedipine