The action of toxins on the voltage-gated sodium channel.
The author discusses the recent findings concerning the influence of selected neurotoxins on the voltage-gated sodium channel. Sodium voltage-gated channels are blocked or modified by four of five classes of neurotoxical agents: guanidinum toxins (tetrodotoxin, saxitoxin), lipid soluble compounds (veratridine, grayanotoxin, batrachotoxin, aconitine, pyrethroids, brevetoxins), polipeptide toxins (alpha-scorpion and sea anemone toxins) and beta-scorpion toxins. The mode of operation of these toxins at the different binding sites within the channel is discussed.
Janiszewski
L
L
Department of Animal Physiology N. Copernicus University, Toruń, Poland.
D001665:Binding Sites; D009498:Neurotoxins / Q000494:pharmacology*; D015222:Sodium Channels / Q000187:drug effects* / Q000502:physiology
D009498:Neurotoxins; D015222:Sodium Channels