title: Elastase is a constituent product of T cells.
abstract: Proteases produced by immune cells have been found to be important components of the immune response to antigen. A protease previously unrecognized as a specific T cell product has been identified which has the gene sequence, serologic crossreactivity, and enzymatic specificity of elastase. T cell elastase, found in combination with the natural elastase inhibitor alpha 1-antitrypsin (alpha 1-protease inhibitor, alpha 1-PI), is produced by both CD4+ and CD8+ T lymphocytes, and is found both in a membrane-bound and in a soluble form in murine T cell lines.
authors.affiliation: Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill 27599-7455.
authors.forename: C L
authors.initials: CL
authors.lastname: Bristow
authors.forename: L K
authors.initials: LK
authors.lastname: Lyford
authors.forename: D P
authors.initials: DP
authors.lastname: Stevens
authors.forename: P M
authors.initials: PM
authors.lastname: Flood
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D001483:Base Sequence; D015153:Blotting, Western; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D006825:Hybridomas / Q000201:enzymology / Q000276:immunology; D007700:Kinetics; D051379:Mice; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D010179:Pancreas / Q000201:enzymology; D010196:Pancreatic Elastase / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D013379:Substrate Specificity; D013552:Swine; D016176:T-Lymphocyte Subsets / Q000201:enzymology / Q000276:immunology; D013601:T-Lymphocytes / Q000201:enzymology* / Q000276:immunology; D000515:alpha 1-Antitrypsin / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D016827:CD8 Antigens; D009838:Oligodeoxyribonucleotides; D000515:alpha 1-Antitrypsin; D010196:Pancreatic Elastase