Changes of rabbit platelet function on simultaneous administration of ticlopidine hydrochloride and OKY-046.
Ticlopidine hydrochloride 180 mg was given orally to rabbits and OKY-046 50 mg was simultaneously administered intravenously. Ticlopidine inhibited the platelet aggregation induced by ADP when the Ticlopidine was orally administered separately, but the platelet aggregation induced by PAF, collagen and arachidonic acid (A.a.) was not significantly decreased. Simultaneous administration of Ticlopidine and OKY-046, as compared to administration of Ticlopidine alone, led to a significant decrease in the platelet aggregation induced by A.a. and collagen. The simultaneous administration did not give rise to an additive or synergistic effect on the platelet aggregation induced by ADP.
Kosugi
T
T
Department of Physiology, School of Medicine, University of the Ryukyus, Okinawa, Japan.
Nakamura
M
M
Saitoh
S
S
Kinjoh
K
K
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D004347:Drug Interactions; D004357:Drug Synergism; D008689:Methacrylates / Q000008:administration & dosage / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013223:Statistics as Topic; D013988:Ticlopidine / Q000008:administration & dosage / Q000494:pharmacology*
D008689:Methacrylates; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D003094:Collagen; C034364:ozagrel; D013988:Ticlopidine