The pharmacologic treatment of neuroleptic-induced akathisia.
Akathisia is a frequent and distressing side effect of neuroleptic medications. The literature regarding the pharmacologic treatment of acute neuroleptic-induced akathisia is critically reviewed, including nine reports of the use of anticholinergic agents, 15 of the use of beta-blocking agents, and six of the use of benzodiazepines. Reports of trials on clonidine, amantadine, piracetam, and of a patient treated with amitriptyline are also discussed. Tentative recommendations for the management of acute akathisia are proposed.
Fleischhacker
W W
WW
Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, New York.
Roth
S D
SD
Kane
J M
JM
D017109:Akathisia, Drug-Induced; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy; D006801:Humans; D011595:Psychomotor Agitation / Q000188:drug therapy
D014150:Antipsychotic Agents