The concentration of dopamine and related monoamines in arteries and some other tissues of the sheep.
1. The highest concentrations of dopamine were observed in the sheep coronary interventricular artery (1.0 micrograms/g) and the lowest in the aorta (0.15 micrograms/g). Varying proportions of noradrenaline was also present in the arteries examined with dopamine:noradrenaline ratios ranging from 0.08 to 1.11. 2. p-Tyramine is the trace amine present in highest concentration in both the lung and the caudate nucleus (21.3 and 10.5 ng/g, respectively) while the levels of beta-phenylethylamine, m-tyramine and tryptamine are lower and range between 1.6 and 4.2 ng/g. 3. The results show that sheep arteries, lung and duodenum contain considerable amount of dopamine that is presumably associated with chromaffin cells. It is most likely that these cells also contain 5-hydroxytryptamine while the localization of trace amines remains to be elucidated.
Juorio
A V
AV
Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada.
Chedrese
P J
PJ
D000818:Animals; D001158:Arteries / Q000032:analysis*; D015306:Biogenic Monoamines / Q000032:analysis*; D001923:Brain Chemistry; D004298:Dopamine / Q000032:analysis*; D004386:Duodenum / Q000032:analysis; D005260:Female; D008168:Lung / Q000032:analysis; D009928:Organ Specificity; D012756:Sheep / Q000378:metabolism*
D015306:Biogenic Monoamines; D004298:Dopamine