[Excitatory amino acids, central nervous system neurotransmitters].
Excitatory amino acids play a crucial role in cerebral transmission. Numerous neuronal systems have been identified contributing to learning, memory and brain neuronal plasticity. Recent advances in neuropathology led to propose a crucial role of these neurotransmitters in neurodegenerative processes and acute cerebral strokes due to their excitotoxic properties. Consequently, development of excitatory amino acid antagonists constitutes a challenge for modern neuropharmacology.
Nieoullon
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Université Aix-Marseille II, Laboratoire de Neurosciences Fonctionnelles du CNRS, Marseille.
D000596:Amino Acids / Q000494:pharmacology*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D002490:Central Nervous System / Q000166:cytology / Q000187:drug effects*; D005971:Glutamates / Q000494:pharmacology; D006801:Humans; D016202:N-Methylaspartate; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D017981:Receptors, Neurotransmitter / Q000145:classification
D000596:Amino Acids; D005971:Glutamates; D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter; D001224:Aspartic Acid; D016202:N-Methylaspartate
Les acides aminés excitateurs, neuromédiateurs du système nerveux central.