title: [The characteristics of the antibody response of animals immunized with components of the surface structures of Francisella tularensis].
abstract: Antibody formation in animals immunized with one of the components of F. tularensis surface structures was studied. The time course of antibody formation in 20 hamadryas baboons was studied in the passive hemagglutination (PHA) test, microagglutination (MA) test, and indirect enzyme immunoassay, used for the determination of IgG, IgA and IgM antibodies. The character of antibody response in the animals immunized with components of F. tularensis surface structures (S-complex) and with live tularemia vaccine was compared. The study revealed that immunization with the S-complex induced the formation of antibodies detected by all three methods. Antibody formation to the S-complex was found to be dose-dependent. With the increase of the injected dose of the S-complex, antibody titers determined in the PHA test decreased and those determined in the MA test increased, which was seemingly due to the induction of antibodies differing in their isotypes. After immunization with the S-complex the levels of IgG antibodies were lower and the levels of IgM antibodies by day 28 after immunization higher than after the injection of live tularemia vaccine.
authors.forename: S V
authors.initials: SV
authors.lastname: Iurov
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Pchelintsev
authors.forename: S S
authors.initials: SS
authors.lastname: Afanas'ev
authors.forename: A A
authors.initials: AA
authors.lastname: Vorob'ev
authors.forename: N N
authors.initials: NN
authors.lastname: Urakov
authors.forename: G V
authors.initials: GV
authors.lastname: Cherenkova
authors.forename: N B
authors.initials: NB
authors.lastname: Denisova
authors.forename: K K
authors.initials: KK
authors.lastname: Fedortsov
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005604:Francisella tularensis / Q000276:immunology*; D007114:Immunization / Q000379:methods*; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007132:Immunoglobulin Isotypes / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D010215:Papio; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001428:Bacterial Vaccines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M
vernacular_title: Osobennosti antitel'nogo otveta u zhivotnykh, immunizirovannykh komponentami poverkhnostnykh struktur Francisella tularensis]