Peritoneal fibrinolytic activity and intra-abdominal adhesions.
The mechanisms leading to reduction of peritoneal fibrinolytic activity in conditions that are associated with the formation of intra-abdominal adhesions were studied. Tissue plasminogen activator was found, by antibody inhibition techniques, to be the activator of fibrinolysis in homogenates of control peritoneum (n = 6). Homogenates of control (n = 10) and inflamed peritoneum (n = 10) were analysed. Plasminogen activating activity was much lower in inflamed peritoneum (median 0.07 IU/cm2) than in control tissue (median 12.0 IU/cm2) (p less than 0.001). Levels of tissue plasminogen activator and alpha 2-antiplasmin were similar in both control and inflamed tissue. Plasminogen activator inhibitor-1, not detectable in control peritoneum, was present in inflamed tissue and might be the reason for the reduction in functional fibrinolytic activity.
Vipond
M N
MN
Academic Surgical Unit, St Mary's Hospital, London, UK.
Whawell
S A
SA
Thompson
J N
JN
Dudley
H A
HA
D000005:Abdomen / Q000601:surgery*; D001706:Biopsy; D005069:Evaluation Studies as Topic; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology; D010532:Peritoneal Diseases / Q000473:pathology / Q000503:physiopathology*; D015849:Plasminogen Inactivators / Q000032:analysis; D000267:Tissue Adhesions / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D010959:Tissue Plasminogen Activator / Q000032:analysis*
D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator