Influence of neonatal hypothyroidism on adrenal tyrosine hydroxylase activation in the young rat.
1. Adrenal TH activation was elicited in young rats (aged 4, 6 and 14 days) by insulin hypoglycaemia. In the control rats, TH activation varied between 125 and 147% above basal values. 2. Neonatal hypothyroidism induced by PTU treatment impaired TH activation. Compensatory treatment with T3 to the PTU-treated young rats led to a return to control activation.
Valens
M
M
Laboratoire d'Endocrinologie, Université de Paris-Sud, Orsay, France.
Gripois
D
D
D000311:Adrenal Glands / Q000201:enzymology; D000818:Animals; D004789:Enzyme Activation; D005260:Female; D007003:Hypoglycemia / Q000139:chemically induced / Q000201:enzymology; D007037:Hypothyroidism / Q000139:chemically induced / Q000201:enzymology*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D011441:Propylthiouracil; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology; D013961:Thyroid Gland / Q000502:physiology; D014284:Triiodothyronine / Q000097:blood; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D007328:Insulin; D014284:Triiodothyronine; D012965:Sodium Chloride; D011441:Propylthiouracil; D014446:Tyrosine 3-Monooxygenase