Plasma concentrations and analgesic effect of EMLA (lidocaine/prilocaine) cream for the cleansing of leg ulcers.
Plasma concentrations of lidocaine and prilocaine were assessed in 8 patients after the application of 8-10 g EMLA 2% cream for 60 min to leg ulcers measuring 31-80 cm2. Maximum individual plasma concentrations were 205 ng/ml for lidocaine and 79 ng/ml for prilocaine, which is twenty times lower than those associated with toxicity. The analgesic effect of EMLA 2% and 5% cream for the surgical cleansing of leg ulcers was compared in a double-blind, four-period, cross-over study in 10 patients. The ulcer was covered with a thick layer of cream for 30 min before four consecutive debridements 1-4 days apart. While the 2% and 5% creams had similar analgesic effects post-cleansing pain tended to be more frequent with the 2% cream.
Enander Malmros
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Department of Dermatology, Central Hospital, Boden, Sweden.
Nilsen
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Lillieborg
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D000368:Aged; D000369:Aged, 80 and over; D000779:Anesthetics, Local / Q000032:analysis*; D004311:Double-Blind Method; D004338:Drug Combinations / Q000032:analysis; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000097:blood*; D008012:Lidocaine / Q000032:analysis*; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D008875:Middle Aged; D009824:Ointments; D010147:Pain Measurement; D011318:Prilocaine / Q000032:analysis*; D011897:Random Allocation
D000779:Anesthetics, Local; D004338:Drug Combinations; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments; D011318:Prilocaine; D008012:Lidocaine