Poliovirus-mediated entry of pokeweed antiviral protein.
Infection of HeLa cells with poliovirus results in cell permeabilization to pokeweed antiviral protein. Cell permeabilization was dependent on the integrity of virus capsid proteins and directly proportional to the multiplicity of infection. This study demonstrates that virus adsorption is sufficient for the entry of pokeweed antiviral protein into poliovirus-infected cells.
Lee
T
T
Department of Biology, Southwest Texas State University, San Marcos 78666.
Crowell
M
M
Shearer
M H
MH
Aron
G M
GM
Irvin
J D
JD
D000998:Antiviral Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D006367:HeLa Cells; D009699:N-Glycosyl Hydrolases; D010940:Plant Proteins / Q000494:pharmacology*; D017955:Poliovirus / Q000187:drug effects*; D054789:Ribosome Inactivating Proteins, Type 1; D014764:Viral Proteins / Q000096:biosynthesis
D000998:Antiviral Agents; D010940:Plant Proteins; D054789:Ribosome Inactivating Proteins, Type 1; D014764:Viral Proteins; D009699:N-Glycosyl Hydrolases; C024275:pokeweed antiviral protein