Evidence for melanin concentrating hormone (MCH) receptors mediating melanosome aggregation in Labeo melanophores.
Melanin concentrating hormone (MCH: 5 x 10(-12)-5 x 10(-8) M) induced a concentration related, rapid and reversible pigment aggregation in innervated melanophores of Labeo rohita. In inducing melanosome aggregation MCH was found to be 10(4) times more potent than norepinephrine. Experiments employing phentolamine and propranolol suggest that MCH acts through its own specific receptors on the melanophores unrelated to adrenoceptors. MCH was able to aggregate the melanosomes even in the absence of extracellular Ca2+.
Jain
A K
AK
Pigment Cell Biology Unit, School of Studies in Zoology, Jiwaji University, Gwalior.
Patil
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S
D000818:Animals; D002118:Calcium / Q000502:physiology; D002347:Carps / Q000502:physiology*; D002449:Cell Aggregation / Q000187:drug effects; D007028:Hypothalamic Hormones; D066298:In Vitro Techniques; D008543:Melanins / Q000378:metabolism*; D008544:Melanocytes / Q000187:drug effects*; D008547:Melanophores / Q000187:drug effects*; D009411:Nerve Endings / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D010907:Pituitary Hormones / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000187:drug effects*; D012867:Skin / Q000166:cytology
D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; D011956:Receptors, Cell Surface; C019463:melanin-concentrating hormone; D011433:Propranolol; D002118:Calcium; D009638:Norepinephrine; D010646:Phentolamine