title: Bleeding in acute promyelocytic leukemia (APL): fibrinolysis or defibrination?
abstract: The coagulation abnormalities in 20 cases of acute promyelocytic leukemia (APL) treated at a single institution were reviewed. A remarkably uniform picture of defibrination and increased FDPs with well-preserved levels of other coagulation factors including AT-III was seen. Our data, together with those available in the literature, do not support DIC as the underlying mechanism of bleeding but seem rather to point to increased proteolysis as the cause.
authors.affiliation: Servicio de Hematología, Hospital Clínico de San Carlos, Madrid, Espagne.
authors.forename: I
authors.initials: I
authors.lastname: Krsnik
authors.forename: A
authors.initials: A
authors.lastname: Escribá
authors.forename: M
authors.initials: M
authors.lastname: López-Rubio
authors.forename: C
authors.initials: C
authors.lastname: Alarcón
authors.forename: E
authors.initials: E
authors.lastname: del Potro
authors.forename: J
authors.initials: J
authors.lastname: Díaz-Mediavilla
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000209:etiology*; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D005342:Fibrinolysis / Q000502:physiology*; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000503:physiopathology*; D008297:Male; D012189:Retrospective Studies
chemical_list: D005337:Fibrin