[Linear porokeratosis of Mibelli in monozygotic twin girls].
Two monozygotic female twins with linear porokeratosis of Mibelli are described. One had only minimal lesions of the right elbow. The other had a linear lesion of the right arm following Blaschko's lines. Monozygotism was established using DNA fingerprinting. A single-gene defect of variable expressivity involving the clonal development of epidermal cutaneous cells according to the lines of cutaneous embryogenesis is suspected. Dithranol and carbon dioxide laser treatment are discussed.
Guillot
P
P
Service de Dermatologie, Hôpital des Enfants, Bordeaux.
Taieb
A
A
Fontan
I
I
Bilhou-Nabera
C
C
Viard
E
E
Renaud
P
P
Maleville
J
J
D000875:Anthralin / Q000627:therapeutic use; D002648:Child; D016172:DNA Fingerprinting; D004200:Diseases in Twins / Q000235:genetics*; D005050:Etretinate / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007642:Keratosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D053685:Laser Therapy; D012867:Skin / Q000196:embryology; D014430:Twins, Monozygotic
D005050:Etretinate; D000875:Anthralin
Porokératose de Mibelli linéaire chez des jumelles monozygotes.