Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily.
Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. Using a panel of human-rodent cell hybrids that preferentially segregate human chromosomes and in situ hybridization, the MDNCF/IL-8 gene was placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon-gamma induced factor) of the platelet factor 4 gene super-family reside. In addition, a restriction fragment length polymorphism was identified using MDNCF as a probe in screening genomic DNA digested with HindIII from unrelated individuals.
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Program Resources, Inc., National Cancer Institute, Frederick Cancer Research Facility, MD 21701.
Dean
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Seuanez
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Mukaida
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N
Matsushima
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O'Brien
S J
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D002630:Chemotactic Factors / Q000235:genetics*; D002871:Chromosome Banding; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D016209:Interleukin-8; D007378:Interleukins / Q000235:genetics*; D008297:Male; D009000:Monocytes; D005810:Multigene Family; D010375:Pedigree; D010978:Platelet Factor 4 / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
D002630:Chemotactic Factors; D016209:Interleukin-8; D007378:Interleukins; D010978:Platelet Factor 4