The effect of age of exposure on lead-induced testicular toxicity.
The present study was designed to assess the significance of age of exposure on the expression of lead toxicity on the male gonad. Male Wistar rats, age 42 days, 52 days and 70 days were treated with lead acetate in their water for 30 days prior to sacrifice. The lead treated groups in all cases had blood lead values significantly greater than control animals. Blood lead levels in control animal groups were less than 7 micrograms/dl. Serum testosterone and sperm concentration and production rate were significantly suppressed in those animals that were exposed to lead acetate starting at age 52 days and 70 days, but not 42 days. These data indicate that prepubertal rats may be less sensitive to the toxic effects of lead than are rats whose exposure begins after puberty has been initiated.
Sokol
R Z
RZ
Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance 90509.
Berman
N
N
D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007854:Lead / Q000097:blood / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009942:Organometallic Compounds / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013076:Sperm Count / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013733:Testicular Diseases / Q000139:chemically induced*; D013739:Testosterone / Q000097:blood
D009942:Organometallic Compounds; D007854:Lead; D013739:Testosterone; C008261:lead acetate