Structure and function of a pentapeptide isolated from the gut of the eel.
A novel peptide, H-Gly-Phe-Trp-Asn-Lys-OH, was isolated from eel guts. This peptide, termed eel intestinal pentapeptide (EIPP), enhanced the frequency of the spontaneous contractions and increased the basal tone of the circular muscle of the esophagogastric junction. Furthermore, EIPP enhanced the spontaneous contractions of the longitudinal muscle strips of the gut and stomach, and of the circular muscle of the gastro-intestinal junction. The peptide may be a physiological regulatory peptide in the gastro-intestinal tract of the eel.
Uesaka
T
T
Laboratory of Physiology, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
Ikeda
T
T
Kubota
I
I
Muneoka
Y
Y
Ando
M
M
D000595:Amino Acid Sequence; D000811:Anguilla; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004064:Digestive System / Q000187:drug effects; D004068:Digestive System Physiological Phenomena; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D009842:Oligopeptides; C071385:eel intestinal pentapeptide