Serum albumin metabolism in rheumatic diseases: relationship to corticosteroids and peptic ulcer.
Serum albumin concentrations and albumin metabolism were assessed in 150 patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and healthy subjects. Hypoalbuminemia was more marked in RA patients than in SLE patients. There was no correlation in RA patients between albumin levels and either disease activity or glucocorticosteroid administration; however, hypoalbuminemia in RA patients significantly correlated with juxta-articular erosions or with the incidence of peptic ulcer. The incidence of peptic ulcer was higher in RA patients with the combination of hypoalbuminemia and corticoid therapy, and reduced by the injection of anabolic steroid. In contrast, anabolic steroid did not improve hypoalbuminemia and bony erosions in the patients. The fractional catabolic rate of albumin was similarly elevated in both RA and SLE, while the absolute catabolic rate was increased to a greater extent in SLE patients. This explains the differences in serum albumin concentration between the patients with RA and SLE.
Niwa
Y
Y
Department of Internal Medicine, Shimane Medical University, Japan.
Iio
A
A
Niwa
G
G
Sakane
T
T
Tsunematsu
T
T
Kanoh
T
T
D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D001327:Autoimmune Diseases / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D015994:Incidence; D007596:Joints / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009277:Nandrolone / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D010003:Osteoarthritis / Q000097:blood / Q000150:complications / Q000188:drug therapy; D010437:Peptic Ulcer / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology*; D011239:Prednisolone / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D012709:Serum Albumin / Q000172:deficiency / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012709:Serum Albumin; D009277:Nandrolone; D011239:Prednisolone; D000077603:Nandrolone Decanoate