Neither adrenergic nor cholinergic antagonists in the central nervous system affect 2-deoxy-D-glucose(2-DG)-induced hyperglycemia.
To investigate whether the brain adrenergic and cholinergic neurotransmitter systems are involved in the regulation of 2-deoxy-D-glucose (2-DG)-induced hyperglycemia, we studied the effects of adrenergic and cholinergic antagonists on 2-DG-induced secretion of epinephrine and glucagon, and hyperglycemia, in anesthetized fed rats. When 2-DG (10 mg/10 microliters) was injected into the third cerebral ventricle, hepatic venous plasma glucose, glucagon, and epinephrine concentrations were significantly increased. Co-administration of phentolamine, propranolol, atropine and hexamethonium (1 X 10(-7) mol) with 2-DG did not modify the hyperglycemia and hormonal responses normally observed after the administration of 2-DG alone. From this evidence we concluded that neither brain adrenoceptive nor cholinoceptive neurons are involved in the regulation of 2-DG-induced hyperglycemia.
Iguchi
A
A
Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Gotoh
M
M
Matsunaga
H
H
Yatomi
A
A
Uemura
K
K
Miura
H
H
Kunoh
Y
Y
Tamagawa
T
T
Sakamoto
N
N
D000320:Adrenergic Fibers / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001786:Blood Glucose; D002490:Central Nervous System / Q000187:drug effects / Q000503:physiopathology*; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology*; D003837:Deoxy Sugars; D003847:Deoxyglucose; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D003837:Deoxy Sugars; D006584:Hexamethonium Compounds; D018738:Hexamethonium; D001285:Atropine; D003847:Deoxyglucose; D011433:Propranolol; D010646:Phentolamine