[Pharmacokinetic interactions between alcohol and acetylsalicylic acid].
Twelve healthy test subjects ingested 0.75 g alcohol/kg body weight in 500 ml carbon dioxide-free mineral water and 1,000 mg powdered acetylsalicylic acid (on average, 13.1 mg/kg body weight) on an empty stomach at 9 a.m. to test the interaction between alcohol and acetylsalicylic acid. Whereas acetylsalicylic acid does not have any effect on the kinetics of alcohol, alcohol effects the metabolism of acetylsalicylic acid. However, an additional restriction of psychophysical performance was not observed.
Locher
K B
KB
Institut für Gerichtliche Medizin, Universität Tübingen.
Mallach
H J
HJ
Moosmayer
A
A
D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000097:blood* / Q000523:psychology; D001241:Aspirin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000431:Ethanol / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology
D000431:Ethanol; D001241:Aspirin
Pharmakokinetische Wechselwirkungen zwischen Alkohol und Acetylsalicylsäure.