title: POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report.
abstract: Peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes are often the presenting features of the POEMS syndrome. Approximately 50% of these are associated with osteosclerotic myeloma, a rare variant of multiple myeloma and some with Castleman's disease, an unusual lympho-proliferative disorder. The underlying pathogenetic mechanisms have not been elucidated but amelioration of symptoms with the disappearance of the M-component suggests possible etiopathogenic mechanisms. We present a 40-year-old woman with manifestations of all three disorders.
authors.affiliation: Department of Medicine, University of Malaya, Kuala Lumpur.
authors.forename: J
authors.initials: J
authors.lastname: Bosco
authors.forename: R
authors.initials: R
authors.lastname: Pathmanathan
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000150:complications* / Q000473:pathology; D005871:Castleman Disease / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology; D016878:POEMS Syndrome / Q000150:complications*