New antitumor substances, BE-12406A and BE-12406B, produced by a streptomycete. II. Structure determination.
The structure of BE-12406A and BE-12406B, which were isolated from the culture broth of a streptomycete as antitumor substances, were determined by means of spectral analyses and chemical studies. The structure of BE-12406A is 1-hydroxy-10-methoxy-8-methyl-12-alpha- L-rhamnopyranosyloxy-6H-benzo[d]naphtho[1,2-b]pyran-6-one, and that of BE-12406B is 1,10-dihydroxy-8-methyl-12-alpha-L-rhamnopyranosyloxy-6H- benzo[d]naphtho[1,2-b]pyran-6-one.
Nakajima
S
S
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
Kojiri
K
K
Suda
H
H
Okanishi
M
M
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D001578:Benzopyrans / Q000737:chemistry; D003374:Coumarins; D006027:Glycosides; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D013302:Streptomyces / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; D003374:Coumarins; D006027:Glycosides; C071794:BE 12406A; C071793:BE 12406B; C031782:gilvocarcin M; C047300:defucogilvocarcin V