title: Significant changes of bronchial responsiveness to methacholine after early asthmatic reaction to toluene diisocyanate (TDI) in a TDI-sensitive asthmatic worker.
abstract: Current asthma is often diagnostically excluded by the presence of normal bronchial responsiveness. We report on a TDI-induced occupational asthma patient with normal bronchial responsiveness. He had suffered from shortness of breath during and after TDI exposure for several months. His initial methacholine bronchial challenge test showed a negative response. The bronchoprovacation test with TDI showed an isolated immediate bronchoconstriction. The following methacholine bronchial challenge tests revealed that the bronchial hyperresponsiveness developed seven hours after the TDI challenge (methacholine PC20:5.1 mg/ml), progressed up until 24 hours, and returned to normal on the seventh day. This case provides evidence that the response of the airway to TDI may not always be accompanied by bronchial hyperresponsiveness to methacholine. Screening programs utilizing methacholine challenges may not always identify TDI-sensitized asthmatic workers.
authors.affiliation: Department of Chest Medicine, National Medical Center, Seoul, Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Park
authors.forename: Y S
authors.initials: YS
authors.lastname: Cho
authors.forename: J N
authors.initials: JN
authors.lastname: Park
authors.forename: J H
authors.initials: JH
authors.lastname: Baik
authors.forename: N S
authors.initials: NS
authors.lastname: Rhu
authors.forename: D I
authors.initials: DI
authors.lastname: Cho
authors.forename: J W
authors.initials: JW
authors.lastname: Kim
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects*; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D009784:Occupational Diseases / Q000139:chemically induced*; D012882:Skin Tests; D013997:Time Factors; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects*
chemical_list: D016210:Methacholine Chloride; D014051:Toluene 2,4-Diisocyanate