title: Antibiotic prophylaxis in ear, nose and throat surgery: a comparison of a single preoperative dose with three peri-operative doses of ceftazidime.
abstract: An open prospective randomized trial was conducted in three Italian ear, nose and throat (ENT) surgery departments on 120 patients aged 10 to 84 years, to compare a single pre-operative dose vs. three peri-operative doses of ceftazidime in surgical prophylaxis. Sixty patients in group I received 1 g ceftazidime intramuscularly (im) or intravenously (iv) 1 h before surgery, and 60 in group II received three 1 g doses of ceftazidime, im or iv, 1 h before, and 6 and 12 h after surgery. Post-operative infections were observed in six group I patients (10.1%) and seven group II patients (11.6%). All infections arose in patients who had undergone 'moderate-risk' (6.7%) or 'high-risk' surgery (30.5%). We conclude that a single pre-operative 1 g dose of ceftazidime is as efficacious as multiple peri-operative doses in the prophylaxis of infectious complications following this type of surgery.
authors.affiliation: ENT Department, Hospital of Viterbo, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Marcucci
authors.forename: A
authors.initials: A
authors.lastname: Vellucci
authors.forename: P
authors.initials: P
authors.lastname: Miani
authors.forename: E
authors.initials: E
authors.lastname: Pallestrini
authors.forename: G
authors.initials: G
authors.lastname: Garaventa
authors.forename: M
authors.initials: M
authors.lastname: Marasca
authors.forename: M
authors.initials: M
authors.lastname: Piemonte
authors.forename: R
authors.initials: R
authors.lastname: Panebianco
authors.forename: M
authors.initials: M
authors.lastname: Benedetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002442:Ceftazidime / Q000008:administration & dosage* / Q000627:therapeutic use; D003428:Cross Infection / Q000517:prevention & control; D005260:Female; D006801:Humans; D017053:Infection Control; D007239:Infections / Q000453:epidemiology; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic
chemical_list: D002442:Ceftazidime