Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.
Chromosomal locations have been assigned to seven members of the TGF-beta superfamily using an interspecific mouse backcross. Probes for the Tgfb-1, -2, and -3, Bmp-2a and -3, and Vgr-1 genes recognized only single loci, whereas the Bmp-2b probe recognized two independently segregating loci (designated Bmp-2b1 and Bmp-2b2). The results show that the seven members of the TGF-beta superfamily map to eight different chromosomes, indicating that the TGF-beta family has become widely dispersed during evolution. Five of the eight loci (Tgfb-1, Bmp-2a, Bmp-2b1, Bmp-2b2, Vgr-1) mapped near mutant loci associated with connective tissue and skeletal disorders, raising the possibility that at least some of these mutations result from defects in TGF-beta-related genes.
Dickinson
M E
ME
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Kobrin
M S
MS
Silan
C M
CM
Kingsley
D M
DM
Justice
M J
MJ
Miller
D A
DA
Ceci
J D
JD
Lock
L F
LF
Lee
A
A
Buchberg
A M
AM
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D008817:Mice, Mutant Strains / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D009115:Muridae / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D015291:Transforming Growth Factors / Q000235:genetics*
D015291:Transforming Growth Factors