title: Gossypol and derivatives: a new class of aldose reductase inhibitors.
abstract: Gossypol and 17 derivatives were tested as inhibitors of aldose reductase from human placenta. Gossypol and a number of the derivatives were potent inhibitors. The order of inhibitory activity was interpreted in relation to the Kador-Sharpless pharmacophor model for the aldose reductase inhibitor site. The structural but not the electronic aspects of the model were found to apply to this series of compounds.
authors.affiliation: Department of Biochemistry, University of New Mexico School of Medicine, Albuquerque 87131.
authors.forename: L M
authors.initials: LM
authors.lastname: Deck
authors.forename: D L
authors.initials: DL
authors.lastname: Vander Jagt
authors.forename: R E
authors.initials: RE
authors.lastname: Royer
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D006072:Gossypol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D000449:Aldehyde Reductase; D006072:Gossypol