High-dose methylprednisolone in the treatment of spinal cord injuries.
The Second National Acute Spinal Cord Injury Study (NASCIS II), published in 1990, illustrated the benefits of high-dose steroids in the treatment of acute spinal cord injury. Research into the use of high-dose steroids is reviewed, and proposed mechanisms of action are addressed. Implications for nursing include method and timing of administration and expected complications. A case study is also provided.
Hilton
G
G
San Francisco General Hospital, CA 94110.
Frei
J
J
D000208:Acute Disease; D000328:Adult; D003422:Critical Care / Q000379:methods; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D013116:Spinal Cord / Q000187:drug effects; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000451:nursing
D008775:Methylprednisolone