A double blind trial of botulinum toxin "A" in torticollis, with one year follow up.
A double blind placebo controlled crossover trial was performed of botulinum toxin "A" in 20 patients with spasmodic torticollis. There was a statistically significant benefit for those treated with toxin; 12 on toxin improved objectively, compared with four on placebo (p less than 0.04). After a follow up period of one year, 16 still seemed to benefit from repeated toxin injections. The main side effect was dysphagia, which appeared to be dose related in individual patients.
Moore
A P
AP
Department of Neurological Science, University of Liverpool, UK.
Blumhardt
L D
LD
D000328:Adult; D000368:Aged; D001905:Botulinum Toxins / Q000008:administration & dosage*; D004311:Double-Blind Method; D004576:Electromyography / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D009132:Muscles / Q000294:innervation; D009460:Neurologic Examination; D014103:Torticollis / Q000188:drug therapy* / Q000503:physiopathology
D001905:Botulinum Toxins