Autosomal dominant atrial septal defect of ostium secundum type. Report of three families.
The authors report on three Sicilian families with 17 individuals (10 females and 7 males) in successive generations affected by atrial septal defect of ostium secundum type (S-ASD) without conduction defect. The anomaly was inherited as an autosomal dominant trait. Cytoplasmic inheritance could be excluded, the anomaly being transmitted also by fathers. Familial S-ASD is probably more frequent than commonly reported since cardiological examination of the relatives is not routinely performed in every case of apparently sporadic ASD.
Li Volti
S
S
Institutes of Pediatric Department, University of Catania, Italy.
Distefano
G
G
Garozzo
R
R
Romeo
M G
MG
Sciacca
P
P
Mollica
F
F
D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005799:Genes, Dominant; D006337:Heart Murmurs / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D006344:Heart Septal Defects, Atrial / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012802:Sicily