title: Metabolism and disorders of the endocrine pancreas.
abstract: The release of insulin evoked by D-glucose and other nutrient secretagogues in the pancreatic B-cell is causally linked to an increase in ATP generation rate. This fuel concept is documented by the higher glycolytic and secretory responses evoked by the alpha-anomer, as distinct from beta-anomer, of either D-glucose or D-mannose. Experimental models of B-cell dysfunction are characterized by several site-specific anomalies in hexose metabolism. For instance, alpha-stereospecificity of the functional response is apparently perturbed in spontaneously diabetic rats or human subjects. Because phosphoglucoisomerase participates in the anomeric specificity of D-glucose metabolism, the intrinsic properties of this enzyme are reevaluated, with emphasis on both the anomeric specificity and discrimination towards hydrogen isotopes as assessed by magnetic resonance imaging.
authors.affiliation: Laboratory of Experimental Medicine, Brussels Free University, Belgium.
authors.forename: W J
authors.initials: WJ
authors.lastname: Malaisse
authors.forename: R
authors.initials: R
authors.lastname: Willem
authors.forename: F
authors.initials: F
authors.lastname: Malaisse-Lagae
authors.forename: D
authors.initials: D
authors.lastname: Zähner
authors.forename: V
authors.initials: V
authors.lastname: Leclercq-Meyer
authors.forename: A
authors.initials: A
authors.lastname: Sener
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism*; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism*; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000378:metabolism* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D051381:Rats
chemical_list: D005956:Glucose-6-Phosphate Isomerase