Radiation-induced myeloid leukemia in C3H/He mice and the effect of prednisolone acetate on leukemogenesis.
We found that the incidence of spontaneous myeloid leukemia in C3H/He male mice was less than 1%, but it could be increased considerably by total-body X irradiation. The induction of myeloid leukemia was seen to increase after doses from 0.47 Gy (3%) to 2.84 Gy (23.9%), and then decrease after a dose of 4.73 Gy (13.6%). The administration of prednisolone acetate (synthesized glucocorticoid) after irradiation resulted in a significant increase in the incidence of myeloid leukemia from 23.9 to 38.5% after a dose of 2.84 Gy; however, corticosterone, a glucocorticoid secreted by cells, did not have such an enhancing effect.
Seki
M
M
Division of Physiology and Pathology, National Institute of Radiological Sciences, Chiba, Japan.
Yoshida
K
K
Nishimura
M
M
Nemoto
K
K
D000818:Animals; D003345:Corticosterone / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D007951:Leukemia, Myeloid / Q000209:etiology*; D007953:Leukemia, Radiation-Induced / Q000209:etiology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D014916:Whole-Body Irradiation
C009935:prednisolone acetate; D011239:Prednisolone; D003345:Corticosterone