Giardiasis--a simple diagnosis that is often delayed.
In a retrospective study performed on 125 patients with histologically diagnosed giardiasis, it is shown that this disease can lead to a variegated picture involving numerous gastroenterological symptoms. The main symptoms noted were epigastralgia (41%), diarrhoea (32%), nausea and vomiting (23%), and loss of weight (20%). The material for histological diagnosis was obtained in hospitals in 49% of the cases, in the doctor's office in 32%, and in two gastroenterological rehabilitation centres in 19%. The average duration of symptoms before establishment of the diagnosis was 2.01 years (range: 1 week to 30 years). In only 8% of the cases was the disease preceded by a visit to an endemic area. Treatment with nitroamidazole preparations completely relieved symptoms in 78% of the patients and remained unsuccessful in 4%; for the remaining 18% of the patients, no follow-up data were available. On the basis of these results, it is recommended that in patients with upper abdominal pain, diarrhoea, loss of weight, meteorism, flatulence, nausea and vomiting, the possibility of giardiasis should be considered, and that during endoscopy, two or three forceps biopsies should be obtained from macroscopically normally-appearing mucosa of the descending part of the duodenum to enable a histological search for Giardia lamblia.
Stolte
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Institut für Pathologie Klinikum Bayreuth, Bundesrepublik Deutschland.
Vögele-Dirks
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000994:Antitrichomonal Agents / Q000627:therapeutic use; D002648:Child; D003951:Diagnostic Errors; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000469:parasitology*; D016829:Giardia lamblia / Q000302:isolation & purification; D005873:Giardiasis / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007413:Intestinal Mucosa / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors
D000994:Antitrichomonal Agents