title: A detailed genetic map of the long arm of chromosome 11.
abstract: We describe 14 new restriction fragment length polymorphisms, corresponding to 13 loci on the long arm of chromosome 11. A detailed genetic map of chromosome 11q has been constructed from these and other loci (a total of 31 loci) typed in 59 reference families. The 23 most informative markers were selected to establish a map with a strongly supported order; regional localizations are provided for eight other markers. The loci span 88 cM in males and 148 cM in females and form a dense continuum on 11q. These ordered polymorphic markers will be of help in studying the genes responsible for several diseases that have been localized to this region, including genes responsible for multiple endocrine neoplasia type I (MEN1), ataxia telangiectasia (AT), tuberous sclerosis (TSC), and some forms of asthma and rhinitis.
authors.affiliation: Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City 84132.
authors.forename: C
authors.initials: C
authors.lastname: Julier
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Lathrop
authors.forename: P
authors.initials: P
authors.lastname: O'Connell
authors.forename: M
authors.initials: M
authors.lastname: Leppert
authors.forename: M
authors.initials: M
authors.lastname: Litt
authors.forename: T
authors.initials: T
authors.lastname: Mohandas
authors.forename: J M
authors.initials: JM
authors.lastname: Lalouel
authors.forename: R
authors.initials: R
authors.lastname: White
mesh_terms: D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D012727:Sex Characteristics
chemical_list: D015342:DNA Probes