RFLP of human immunoglobulin genes.
Human immunoglobulin chains are encoded by variable, diversity, joining and constant gene segments localized on chromosomes 2, 22 (light chains) and 14 (heavy chains). An extensive genetic polymorphism exists as revealed by restriction fragment length polymorphism of the different genes. These new markers allow a more precise delineation of the evolution of the immune system and of genes linked to disease susceptibility.
Hammarström
L
L
Department of Clinical Immunology and Center of Biotechnology, Karolinska Institute, Huddinge Hospital, Sweden.
Ghanem
N
N
Smith
C I
CI
Lefranc
G
G
Lefranc
M P
MP
D005803:Genes, Immunoglobulin / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007127:Immunoglobulin Constant Regions / Q000235:genetics; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length
D007127:Immunoglobulin Constant Regions; D007129:Immunoglobulin Gm Allotypes; D007135:Immunoglobulin Variable Region