[Morphological changes in experimental duodenogastric reflux].
The model of a total duodenal-gastric reflux was developed in 20 dogs and morphological changes in the stomach were studied. 5 dogs served as control. Histologic changes occurred 3.5 months and 1 year after the operation were characterized by metachromasia, increased mucus formation, proliferation of epithelial and parietal cells, moderate inflammation. Process of the disease had fluctuations. 6 months after the operation 5 dogs were reoperated for the elimination of reflux and were observed for another 6 months. A complete reversibility of all changes was established. Bacteriological studies showed a considerable increase of bacteria population in the stomach and a pH increase. The authors suggest the term 'reflux gastropathy" to replace the term "alkaline reflux-gastritis".
Radev
D
D
Strashimirova
N
N
Vasileva
M
M
Dokov
V
V
Radev
R
R
Dimov
D
D
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004285:Dogs; D004383:Duodenogastric Reflux / Q000378:metabolism / Q000473:pathology*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000382:microbiology; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D010503:Periodic Acid-Schiff Reaction; D009626:Terminology as Topic; D013997:Time Factors
Morfologicheskie izmeneniia pri duodenogastral'nom reflekse v éksperimente.