Multidisciplinary treatment for bladder carcinoma--biological response modifiers and kampo medicines.
Authors studied the effects of several biological response modifiers (BRMs) on bladder carcinoma. On carcinogenesis in BBN-induced bladder carcinoma rats, Schizophyllan (SPG) showed inhibition of body weight loss and thymus weight loss. Bladder weight increase was also inhibited. SPG prolonged cancer-bearing survival time, and postponed malignant changes of bladder mucosa. On thymocytes of SPG-treated cancer-bearing rats, rosette-forming thymocytes increased. In clinical study, SPG, OK-432, ubenimex and kampo medicine were used as BRMs. As a result, the number of suppressor-inducer T cells increased, and in cytotoxic T cells a slow fall was observed. On helper-inducer T cells, a slow rise and decrease were noticed in the SPG group, and the reverse tendency was seen in the ubenimex and OK-432 group.
Horii
A
A
Osaka Railway Hospital, Japan.
Kyo
M
M
Asakawa
M
M
Yasumoto
R
R
Maekawa
M
M
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007930:Leucine / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D010844:Picibanil / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012566:Sizofiran / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D007155:Immunologic Factors; C063587:juzentaihoto; D010844:Picibanil; D012566:Sizofiran; D007930:Leucine; C012211:ubenimex