Role of platelet cytosolic calcium in the response to salt intake in normotensive subjects.
1. To investigate the role of cytosolic calcium in salt-induced hypertension, a high salt diet was given to young normotensive subjects with or without a family history of hypertension. 2. A high salt diet raised blood pressure significantly in normotensive subjects with a family history compared with the age and gender matched subjects without a predisposition to hypertension. 3. Platelet cytosolic calcium was increased in predisposed subjects in a control period before salt intake. 4. A positive correlation was observed between the changes in mean blood pressure and cytosolic calcium before high salt intake, although salt loading did not induce any significant change in cytosolic calcium. 5. These results suggest that cytosolic calcium plays a role in elevation of blood pressure induced by salt loading in subjects with a family history of hypertension.
Yamakawa
H
H
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Suzuki
H
H
Nakamura
M
M
Ohno
Y
Y
Saruta
T
T
D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D001794:Blood Pressure; D002118:Calcium / Q000097:blood*; D003600:Cytosol / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D012982:Sodium, Dietary / Q000494:pharmacology*
D010281:Parathyroid Hormone; D012982:Sodium, Dietary; D002118:Calcium