Increase of beta-actin mRNA upon hypotonic perfusion of perfused rat liver.
beta-Actin mRNA levels in livers exposed to hypotonic perfusion (from 305 to 225 mosmol/l) for one hour are increased 2-fold relative to albumin mRNA. Like albumin, glyceraldehyde-3-phosphate dehydrogenase and tyrosine aminotransferase mRNAs remain at the levels observed under normotonic conditions. The increase in beta-actin mRNA is interpreted as a cytoskeletal response due to cell swelling.
Schulz
W A
WA
Institut für Physiologische Chemie I, Heinrich Heine Universität, Düsseldorf, Germany.
Eickelmann
P
P
Hallbrucker
C
C
Sies
H
H
Häussinger
D
D
D000199:Actins / Q000235:genetics*; D000818:Animals; D015152:Blotting, Northern; D066298:In Vitro Techniques; D008297:Male; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D000199:Actins; D012333:RNA, Messenger