The thymus in myasthenia gravis. Changes typical for the human disease are absent in experimental autoimmune myasthenia gravis of the Lewis rat.
In human myasthenia gravis (MG) formation of autoantibodies against acetylcholine receptor (AChR) is commonly associated with thymic changes termed lymphofollicular hyperplasia (LFH). To learn whether the thymic lesions of human MG are primary changes in the autoimmune pathogenesis, or rather secondary events caused by peripheral autoimmunization, the authors compared the pathologic changes of MG thymuses with the thymuses of Lewis rats with experimental autoimmune myasthenia gravis (EAMG). EAMG was induced either actively by immunization with AChR, or transferred passively with monoclonal antibodies (mAb) binding to AChR. The clinical diagnosis of EAMG was confirmed by electromyography. Germinal centers, which are typical for human MG thymuses, were not detectable in the thymus of EAMG rats. Scattered B cells were seen as normal components of the thymic medulla. In EAMG their number was not augmented, nor were they accumulated focally. The perivascular spaces (PVS) were not distended and the amount of reticulin was not increased. Thymic myoid cells were identified in EAMG as well as in control thymuses; their cellular microenvironment was inconspicuous. Both in normal and in EAMG thymuses, a subpopulation of myoid cells expressed the main immunogenic region of the AChR. Heavily affected rats showed a severe cortical involution, but no specific changes of the medulla. The fact that none of the thymic lesions characteristic for human MG was found in EAMG is compatible with the concept that the thymic changes in MG are primary events in the autoimmune pathogenesis of this disease.
Meinl
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E
Max Planck Institute for Psychiatry, Martinsried, Federal Republic of Germany.
Klinkert
W E
WE
Wekerle
H
H
D000818:Animals; D000911:Antibodies, Monoclonal; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D001402:B-Lymphocytes / Q000473:pathology / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D009045:Motor Endplate / Q000166:cytology; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D051381:Rats; D011917:Rats, Inbred Lew; D011950:Receptors, Cholinergic / Q000276:immunology; D013950:Thymus Gland / Q000473:pathology* / Q000502:physiology / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D011950:Receptors, Cholinergic