Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses.
In summary, we have shown that human appendix and murine PP B cells, freshly isolated from normal tissue, respond IL-6 with significant increases in IgA SFC. Further, sIgA+ B cells from appendix express more IL-6R than is seen with B cells isolated from PBMC and spleen. When IgA subclass responses were measured, rhIL-6 induced both IgA1 and IgA2 SFC responses; however, 60-70% of the total response was represented by the IgA2 subclass. Our studies suggest that the human appendix as well as murine PP are enriched sources for sIgA+ B cells which are responsive to cytokines such as IL-6 for induction of IgA plasma cell responses.
McGhee
J R
JR
Department of Microbiology, University of Alabama, Birmingham.
Fujihashi
K
K
Beagley
K W
KW
Kiyono
H
H
D000818:Animals; D001065:Appendix / Q000166:cytology / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000276:immunology* / Q000494:pharmacology; D051379:Mice; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology*
D007070:Immunoglobulin A; D015850:Interleukin-6