The role of p53 in the normal control of cell proliferation.
The regulation of cell proliferation involves p53. A mutant allele of p53, p53-Val135, has been found to be temperature-sensitive for function with separable suppressor and promoter effects on cell proliferation. These opposing suppressor and promoter functions of p53 correlate with two alternative, temperature-sensitive conformations of the p53-Val135 polypeptide.
Milner
J
J
Department of Pathology, University of Cambridge, UK.
D000818:Animals; D002455:Cell Division / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009154:Mutation; D010766:Phosphorylation; D011487:Protein Conformation; D013696:Temperature; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology*
D016159:Tumor Suppressor Protein p53