[Effect of of cervical antitumoral immunity activation on CIN].
The effects on priming and strengthening immunitary action in the uterine portio were assessed in CIN 2 and CIN 3. Use was made of: solution of BCG 0.01 ml (1/10 of a vaccination dose) repeated if necessary after 5 days, diluted with 100,0000 IU of beta-interferon injected radially into the quadrant of the portio; 1.000.000 IU of beta-interferon intradermally for a further 4 days, to be repeated on the basis of local findings. 20 cases of CIN 2 and CIN 3 were analysed. The immediate results are characterised by complete desquamation of the pathological epithelium, intensive lymphoplasmacellular and macrophagic reaction with the presence of lymphofollicles. In two cases (10%), subsequent conisation was carried out because of persisting CIN foci. Given the minimal dose of BCG and interferon, no complications were observed. The combined or sequential action of the two drugs in assessed as well as the speed of spontaneous restitutio ad integrum until a longer follow-up finally confirms results obtained.
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Divisione di Ostetricia e Ginecologia, Stabilimento Ospedaliero-Schio, USL n. 6 Veneto.
D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D001500:BCG Vaccine / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D002584:Cervix Uteri / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007271:Injections, Intradermal; D016899:Interferon-beta / Q000008:administration & dosage*; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D014594:Uterine Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy
D001500:BCG Vaccine; D016899:Interferon-beta
Effetti sul CIN della attivazione della immunità antitumorale cervicale.