Friend virus replication in normal and immunosuppressed C57BL/6 mice.
Young adult C57BL/6 mice are resistant to the replication of Friend virus. We show here that this resistance is not absolute. In 7-week old C57BL/6 mice injected with NB-tropic Friend virus iv, high titers of SFFV could be recovered from the spleen at 8 days after infection but by 21 days, no virus was detectable. A single dose of anti-Thy 1.2 monoclonal antibody iv before FV infection permitted continued replication of SFFV in these animals. This finding strongly supports the hypothesis that SFFV replication in C57BL/6 mice is restricted by a T cell-mediated immune response.
Van der Gaag
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HC
Department of Anatomy, University of Toronto, Canada.
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D000375:Aging; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D005622:Friend murine leukemia virus / Q000502:physiology*; D007113:Immunity, Innate; D007165:Immunosuppression Therapy; D009052:Leukemia Virus, Murine / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000382:microbiology; D013155:Spleen Focus-Forming Viruses / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*; D018800:Thy-1 Antigens; D014779:Virus Replication
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D018800:Thy-1 Antigens