Assessment of chromosome 22 anomalies in neurinomas by combined karyotype and RFLP analyses.
We report the cytogenetic study of 28 neurinomas; sixteen of them were also analysed using 11 polymorphic DNA markers for the loss of alleles of chromosome 22. Partial or total loss of chromosome 22 was found in nine cases. The results of the two approaches appear homogeneous, however, three tumors that yielded only cells with normal karyotypes demonstrated loss of constitutional heterozygosities. One of the tumors, which displayed an isodicentric or isopseudodicentric 22, was obtained in a patient with von Recklinghausen neurofibromatosis. It appears that loss of chromosome 22 is a characteristic of neurinomas whatever their context of occurrence.
Couturier
J
J
C.N.R.S. URA 620, Institut Curie, Section de Biologie, Paris, France.
Delattre
O
O
Kujas
M
M
Philippon
J
J
Peter
M
M
Rouleau
G
G
Aurias
A
A
Thomas
G
G
D000483:Alleles; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002892:Chromosomes, Human, Pair 22; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping; D009442:Neurilemmoma / Q000235:genetics*; D009464:Neuroma, Acoustic / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers