Pain and allodynia in postherpetic neuralgia: role of somatic and sympathetic nervous systems.
The immediate effects of selective sympathetic and somatic blockades on pain and tactile allodynia in 12 patients with long-standing ophthalmic or high cervical postherpetic neuralgia were compared. For the duration of the somatic blockade, pain was completely abolished in 11 patients and allodynia in 8 patients. In contrast, during the sympathetic blockade only one patient reported total pain relief and three a marginal attenuation of pain while eight remained unchanged; and no patient reported clear alleviation of allodynia. After successful somatic blockade, pain and allodynia reappeared with tactile sensation while thermal sensation was still absent. Pain and allodynia appear to be related to sensory impulses travelling along the large rather than the small diameter fibres; and the sympathetic system may only have a limited role.
Nurmikko
T
T
Department of Neurology, University Central Hospital, Tampere, Finland.
Wells
C
C
Bowsher
D
D
D000368:Aged; D001340:Autonomic Nerve Block; D005260:Female; D005727:Ganglia, Spinal / Q000503:physiopathology; D005728:Ganglia, Sympathetic / Q000503:physiopathology; D006562:Herpes Zoster / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D006941:Hyperesthesia / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D009437:Neuralgia / Q000503:physiopathology* / Q000628:therapy; D010147:Pain Measurement; D010148:Intractable Pain / Q000503:physiopathology* / Q000628:therapy; D012684:Sensory Thresholds / Q000502:physiology; D013697:Thermosensing / Q000502:physiology; D014321:Trochlear Nerve / Q000503:physiopathology