[Multicenter study of the effectiveness and tolerance of clotiazepam in cardiology].
In a phase IV study with clotiazepam 9 cardiologists were involved to treat 86 patients (52 female, 32 male, mean age 51 years) effected by cardiovascular diseases and anxiety. The dosage was 5-10 mg TID, and the treatment lasted for 3 weeks. Variations of the dosage were requested in 21% of patients and generally at the 2nd week of treatment. The safety of clotiazepam was good: only in the 14% of patients side-effects were observed (especially drowsiness 9.3% and asthenia 2.3%). Clotiazepam was judged to be effective in 75% of patients. The Hamilton psychiatric rating scale for anxiety showed a progressive decrease both of the total score and of the scores of every item; the cardiovascular symptoms particularly improved at both the controls.
Colonna
L
L
Divisione di Cardiologia, Policlinico Consorziale, Bari.
Cozzi
F
F
Del Citerna
F
F
Di Benedetto
A
A
De Divitiis
O
O
Furlanello
F
F
Milazzotto
F
F
Pittalis
M
M
Taccola
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000150:complications / Q000188:drug therapy*; D001381:Azepines / Q000008:administration & dosage / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000523:psychology*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011569:Psychiatric Status Rating Scales
D001381:Azepines
Studio policentrico sull'efficacia e tollerabilità del clotiazepam in cardiologia.