[Peripheral neuropathy and plasmocytic proliferations. Apropos of 17 cases].
Seventeen cases of peripheral neuropathy with plasmocytic proliferation were grouped together to analyze the clinical manifestations and evolution of this association of symptoms. The plasmocytic proliferation was 5 times that of multiple myeloma, 9 times that of a solitary bone plasmacytoma and 3 times that of a solitary plasmacytoma. The follow-up lasted 1 to 18 years (mean, 8 years) for solitary plasmacytomas. Other cutaneous and endocrinological symptoms, organomegaly and edema were sometimes present. The evolution was relatively severe, except in 6 patients whose solitary plasmacytomas were successfully treated with radiation. Six patients died 2 to 8 years (mean, 5 years) after the onset of neuropathy as a result of a progression of the neuropathy and/or anasarca (4 cases), or acute leukemia (2 cases) abetted by long-term chemotherapy. The therapeutic approaches available, the nature of the plasmocytic proliferation and its association with the neuropathy and the other symptoms are discussed.
Delauche-Cavallier
M C
MC
Service d'Immuno-Hématologie, Hôpital Saint-Louis, Paris.
Clauvel
J P
JP
Danon
F
F
Peraldi
M N
MN
Divine
M
M
Seligmann
M
M
D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000628:therapy; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D010954:Plasmacytoma / Q000150:complications* / Q000628:therapy; D011379:Prognosis; D013997:Time Factors
Neuropathie périphérique et proliférations plasmocytaires. A propos de 17 observations.