[Kinetic characteristics of neuroleptic binding sites on human lymphocytes].
The kinetics and equilibrium of the interaction of [3H]spiperone with binding sites on human lymphocytes have been studied using radioligand analyses. The process of [3H]spiperone binding to these sites can be explained by the model of ligand interaction with two independent binding sites (high-affinity site, KD1 = 3 nM, and low-affinity site, KD2 = 20 nM), thus confirming the heterogeneity of the sites on human lymphocytes.
Izumrudova
I I
II
Zaĭtsev
S V
SV
Koshkin
A A
AA
Porodenko
N V
NV
Varfolomeev
S D
SD
D014150:Antipsychotic Agents / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism*
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; C028051:neuroleptic receptor
Kineticheskie kharakteristiki tsentrov sviazyvaniia neĭroleptikov na limfotsitakh cheloveka.