Acquired immunodeficiency syndrome and Epstein-Barr virus.
Epstein-Barr virus is an important aetiological factor in certain HIV-related syndromes, with its opportunist expression related to the level of host immunodeficiency. In asymptomatic people co-infected with HIV, EBV activity is reflected by increased viral shedding and rises in anti-EBV titres; as immunodeficiency ensues EBV manifests as epithelial hyperproliferation in OHL, and later as B-cell lymphoma in AIDS. The suggested role of EBV as a co-factor in the progression of HIV infection and development of AIDS has not been established, although another herpesvirus, cytomegalovirus, might play such a role. Advances in our understanding of HIV regulation and its interaction with other latent (herpes) viruses should provide important molecular and pharmacological approaches to the clinical management of advanced HIV disease.
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D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000209:etiology; D001402:B-Lymphocytes / Q000276:immunology / Q000382:microbiology; D004938:Esophageal Neoplasms / Q000209:etiology; D006678:HIV / Q000472:pathogenicity; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human; D006801:Humans; D007108:Immune Tolerance; D007971:Leukoplakia / Q000209:etiology; D008232:Lymphoproliferative Disorders / Q000209:etiology; D009062:Mouth Neoplasms / Q000209:etiology