Antioxidant action of propofol on liver microsomes, mitochondria and brain synaptosomes in the rat.
2,6-Diisopropylphenol (propofol), a new intravenous anaesthetic, has a structure similar to that of butylated hydroxytoluene (BHT). Both compounds inhibit the production of malondialdehyde (MDA) in rat liver mitochondria and microsomes as well as in rat brain synaptosomes treated with lipid peroxidation inducers.
Musacchio
E
E
Department of Biological Chemistry, University of Padova, Italy.
Rizzoli
V
V
Bianchi
M
M
Bindoli
A
A
Galzigna
L
L
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001555:Benzene Derivatives / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004579:Electron Transport / Q000187:drug effects; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D015742:Propofol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D000975:Antioxidants; D001555:Benzene Derivatives; D002084:Butylated Hydroxytoluene; D008315:Malondialdehyde; D007501:Iron; C007164:cumene hydroperoxide; D001205:Ascorbic Acid; D015742:Propofol