Two additional cases of isochromosome 21q or translocation 21q21q in hematological malignancies.
We report on 2 patients with isochromosome 21q [i(21q)] or translocation 21q21q [t(21q21q)] in myeloid disorders. Of 18 available cases of i(21q) or t(21q21q), 15 were found in myeloid malignancies, often secondary to a previous carcinogen exposure. Complex karyotypes were found in most cases. Four cases presented with i(21q) or t(21q21q) as the sole anomaly, and this might represent a specific entity.
Huret
J L
JL
Hématologie et Oncologie Médicale, CNRS URA 1338, Poitiers, France.
Schoenwald
M
M
Gabarre
J
J
Vaugier
G L
GL
Tanzer
J
J
D000368:Aged; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000235:genetics*; D014178:Translocation, Genetic