title: Large anaplastic cell Ki-1 positive malignant lymphoma with peculiar endocytotic vacuoles.
abstract: Unusual intracytoplasmic inclusions are occasionally seen in some variants of malignant lymphoma. We report here a case of large anaplastic cell malignant lymphoma with peculiar vacuoles of probable endocytotic origin. Immunological findings demonstrated the characteristics of activated cells typical of a large anaplastic cell Ki-1 positive lymphoma. The tumour cells exhibited a phenotype of peripheral helper-inducer T-cells. The intracytoplasmic vacuoles were positive with the T surface marker antibodies. Ultrastructurally, these inclusions were closely related to the microvesicle-containing vacuoles reported in signet ring cell lymphomas of B or T cell lineage. The mechanism of cytoplasmic vacuole formation is discussed. An endocytotic origin is possible. The resemblance to the "capping" phenomenon in small lymphocytes is stressed.
authors.affiliation: Service Central Jacques Delarue d'Anatomie et de Cytologie Pathologiques, Hôtel-Dieu, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Le Tourneau
authors.forename: J
authors.initials: J
authors.lastname: Audouin
authors.forename: J
authors.initials: J
authors.lastname: Diebold
authors.forename: E
authors.initials: E
authors.lastname: Pujade-Lauraine
authors.forename: A
authors.initials: A
authors.lastname: Bernadou
mesh_terms: D000328:Adult; D000708:Anaplasia / Q000276:immunology / Q000473:pathology; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D008223:Lymphoma / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D014617:Vacuoles / Q000502:physiology / Q000648:ultrastructure*
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen