Male antigen defined serologically does not identify a factor responsible for testicular development.
To test the proposal that the serologically detected male antigen (SDMA; which may or may not be the same as H-Y) was responsible for triggering the indifferent gonad to differentiate into the testis in mammals, H-Y negative sex-reversed XXSxr' male mice were investigated for the presence of SDMA. Serum from C57BL/6 female mice immunized against tissue from XXSxr' males did not contain SDMA specific antibody as detected by the complement-mediated sperm cytotoxicity assay. Thus, although SDMA is a male-specific factor and may play a role in male sex determination, it does not identify the testis-determining factor (TDF).
Goldberg
E H
EH
Department of Microbiology, University of New Mexico School of Medicine, Albuquerque 87131.
McLaren
A
A
Reilly
B
B
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D004268:DNA-Binding Proteins; D012734:Disorders of Sex Development / Q000235:genetics / Q000276:immunology*; D006182:H-Y Antigen; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012733:Sex Differentiation / Q000235:genetics / Q000276:immunology*; D013091:Spermatogenesis / Q000276:immunology*; D013737:Testis / Q000196:embryology; D014960:X Chromosome; D014998:Y Chromosome
D004268:DNA-Binding Proteins; D006182:H-Y Antigen