title: Stability of streptococcal pyrogenic exotoxin production with laboratory manipulation of group A streptococci.
abstract: Because of reported differences in the production of streptococcal pyrogenic exotoxins by group A strains associated with severe streptococcal infections, the stability of exotoxin production by specific strains was examined by passing group A streptococci on blood agar culture plates daily for 20 days. No changes were detected in either exotoxin genes or in exotoxin production during this time, suggesting that these reported differences are due to other explanations such as differences in the strains collected from various geographic areas or to laboratory methodologic differences.
authors.affiliation: Department of Pediatrics, University of Minnesota Medical School, Minneapolis 55455.
authors.forename: E L
authors.initials: EL
authors.lastname: Kaplan
authors.forename: D R
authors.initials: DR
authors.lastname: Johnson
authors.forename: A
authors.initials: A
authors.lastname: Wlazlo
authors.forename: M H
authors.initials: MH
authors.lastname: Kim
authors.forename: P M
authors.initials: PM
authors.lastname: Schlievert
mesh_terms: D001426:Bacterial Proteins; D005098:Exotoxins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins; D011749:Pyrogens / Q000096:biosynthesis* / Q000235:genetics; D013297:Streptococcus pyogenes / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D005098:Exotoxins; D008565:Membrane Proteins; D011749:Pyrogens; C117980:SpeA protein, Streptococcus pyogenes; C027951:erythrogenic toxin