Aromatic and heterocyclic amine metabolism and phenotyping in humans.
Our method to evaluate acetylator phenotype and N-oxidation phenotype with a single caffeine dose and a single urine specimen collection has enabled us to examine acetylation and N-oxidation by two enzyme systems that have a known genetic polymorphism and are important in aromatic amine metabolism. Based on available data, we have hypothesized patients with urinary bladder cancer will have a higher frequency of rapid N-oxidation and slow acetylation phenotypes when compared to controls. On the other hand, patients with colorectal cancer should contain a higher proportion of both rapid N-oxidation phenotype and rapid acetylation phenotype when compared to the control group. In contrast, lung cancer patients, should contain an increased frequency of rapid arylamine N-oxidation phenotypes with the frequency of acetyltransferase phenotype being greater or perhaps the same as in the control group.
Lang
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Dept. of Surgery, School of Medicine, University of Ark. for Med. Sci., Little Rock.
Kadlubar
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D000123:Acetyltransferases / Q000378:metabolism; D000588:Amines / Q000378:metabolism*; D002273:Carcinogens / Q000378:metabolism; D019388:Cytochrome P-450 CYP1A2; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006801:Humans; D006838:Hydrocarbons / Q000378:metabolism*; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D010088:Oxidoreductases / Q000378:metabolism; D010641:Phenotype; D012307:Risk Factors
D000588:Amines; D002273:Carcinogens; D006838:Hydrocarbons; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; D019388:Cytochrome P-450 CYP1A2; D000123:Acetyltransferases; C064931:aromatic amine acetyltransferase