[The effect of cyanides and antidotes on the heart rate in rat heart preparations in situ].
Effects of sodium-cyanide and some of its antidotes and antagonists such as sodium-nitrite, 4-dimethylaminophenol (DMAP), sodium-thiosulphate and alpha-adrenergic blocking agents on the heart rate of rats in situ under conditions of the artificial breathing have been studied. Also, effects of opioid receptor agonist, naloxane, on the heart of the poisoned animals have been studies. Sodium-cyanide causes strong and irreversible effects on the heart rate which are completely abolished by effects of sodium-nitrite, 4-DMAP and sodium-thiosulphate, and partly and timely limited by effects of alpha adrenergic blockers, phenotholamine and promethazine, and to a significantly slower degree by naloxane.
Tadić
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Vojnotehnicki institut, Medicinsko odeljenje.
D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011398:Promethazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012966:Sodium Cyanide / Q000633:toxicity*
D000931:Antidotes; D009270:Naloxone; D011398:Promethazine; D012966:Sodium Cyanide; D010646:Phentolamine
Uticaj cijanida i antidota na frekvenciju srcanog rada u preparaciji srca pacova in situ.