Behavioral effects of Euphorbia hirta L.: sedative and anxiolytic properties.
Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for behavioral effects in mice. The extract did not induce any toxic effect when it was administered i.p. and orally. Sedative properties could be confirmed with high doses (100 mg of dried plant/kg, and more), by a decrease of behavioral parameters measured in non-familiar environment tests (activitest and staircase test), whereas anticonflict effects appeared at lower doses (12.5 and 25 mg of dried plant/kg), by an enhancement of behavioral parameters measured in the staircase test and in the light/dark choice situation test. These findings validate the traditional use of E. hirta as a sedative and reveal original anxiolytic properties.
Lanhers
M C
MC
Laboratoire de Pharmacognosie, Université de Metz, France.
Fleurentin
J
J
Cabalion
P
P
Rolland
A
A
Dorfman
P
P
Misslin
R
R
Pelt
J M
JM
D000818:Animals; D014151:Anti-Anxiety Agents; D001522:Behavior, Animal / Q000187:drug effects*; D003220:Conflict, Psychological; D004305:Dose-Response Relationship, Drug; D005612:Freeze Drying; D006993:Hypnotics and Sedatives; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal / Q000032:analysis*
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D010936:Plant Extracts