title: Spinal cord compression complicating subarachnoid infusion of morphine: case report and laboratory experience.
abstract: The intraspinal administration of morphine has been employed increasingly in the management of intractable pain of malignant as well as benign origin. We have encountered a previously unreported clinical complication: spinal cord compression by an inflammatory tissue mass surrounding a subarachnoid infusion catheter administering morphine, leading to paraplegia. The patient was referred to our institution after catheter and pump implantation for chronic, intractable pain associated with pre-existing lumbar arachnoid fibrosis, after multiple myelograms and surgeries. The patient may, therefore, have had an underlying propensity to foreign body reactions. We have encountered a similar phenomenon, however, in a canine laboratory model. The pathological features in both our patient and our laboratory preparation, with inflammatory tissue masses around the tip of the catheter but not around proximal subarachnoid segments, suggest an effect related to infusion, as opposed to infection or the presence of the catheter. We review the pathological features in both settings and the pertinent literature.
authors.affiliation: Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: R B
authors.initials: RB
authors.lastname: North
authors.forename: P N
authors.initials: PN
authors.lastname: Cutchis
authors.forename: J A
authors.initials: JA
authors.lastname: Epstein
authors.forename: D M
authors.initials: DM
authors.lastname: Long
mesh_terms: D000328:Adult; D000818:Animals; D004285:Dogs; D005260:Female; D006801:Humans; D015918:Infusion Pumps, Implantable; D009020:Morphine / Q000008:administration & dosage*; D009192:Myelography; D010148:Intractable Pain / Q000188:drug therapy; D010264:Paraplegia / Q000209:etiology; D013117:Spinal Cord Compression / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D013346:Subarachnoid Space
chemical_list: D009020:Morphine