title: Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4.
abstract: The generation of antigen-specific antitumor immunity is the ultimate goal in cancer immunotherapy. When cells from a spontaneously arising murine renal cell tumor were engineered to secrete large doses of interleukin-4 (IL-4) locally, they were rejected in a predominantly T cell-independent manner. However, animals that rejected the IL-4-transfected tumors developed T cell-dependent systemic immunity to the parental tumor. This systemic immunity was tumor-specific and primarily mediated by CD8+ T cells. Established parental tumors could be cured by the systemic immune response generated by injection of the genetically engineered tumors. These results provide a rationale for the use of lymphokine gene-transfected tumor cells as a modality for cancer therapy.
authors.affiliation: Department of Medicine, Johns Hopkins University, Baltimore, MD 21205.
authors.forename: P T
authors.initials: PT
authors.lastname: Golumbek
authors.forename: A J
authors.initials: AJ
authors.lastname: Lazenby
authors.forename: H I
authors.initials: HI
authors.lastname: Levitsky
authors.forename: L M
authors.initials: LM
authors.lastname: Jaffee
authors.forename: H
authors.initials: H
authors.lastname: Karasuyama
authors.forename: M
authors.initials: M
authors.lastname: Baker
authors.forename: D M
authors.initials: DM
authors.lastname: Pardoll
mesh_terms: D000818:Animals; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D002455:Cell Division; D002460:Cell Line; D007167:Immunotherapy; D015847:Interleukin-4 / Q000235:genetics* / Q000378:metabolism; D007680:Kidney Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008212:Lymphocyte Depletion; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D015202:Protein Engineering; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014162:Transfection
chemical_list: D015847:Interleukin-4