title: Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease.
abstract: Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.
authors.affiliation: University of Oxford, Department of Psychiatry, Warneford Hospital, UK.
authors.forename: D P
authors.initials: DP
authors.lastname: Geaney
authors.forename: N
authors.initials: N
authors.lastname: Soper
authors.forename: B J
authors.initials: BJ
authors.lastname: Shepstone
authors.forename: P J
authors.initials: PJ
authors.lastname: Cowen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D000704:Analysis of Variance; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D004341:Drug Evaluation; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D010296:Parietal Lobe / Q000098:blood supply; D010830:Physostigmine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000098:blood supply; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D010830:Physostigmine; D006024:Glycopyrrolate