title: Comparison of intravenous oxytocin with and without vaginal prostaglandin E2 gel in term pregnancy with premature rupture of membranes and unfavorable cervix.
abstract: Forty-seven nulliparous term pregnant women with PROM and unfavorable cervix, were randomly divided into 23 patients who were observed for four hours then followed by intravenous oxytocin, and 24 patients who were given 3 mg PGE2 gel intravaginally then followed by intravenous oxytocin four hours later. No statistically significant difference was observed between the two treatment groups with regard to Bishop score four hours after observation, intravenous oxytocin to delivery time, Apgar score at 1 and 5 minutes and maternal puerperal complications in both groups. It can be concluded that PGE2 did not significantly improve Bishop score or shorten the induction to delivery time in cases of PROM with unfavorable cervix. Intravenous oxytocin is still preferable both in terms of cost and effectiveness.
authors.affiliation: Department of Obstetrics & Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Y
authors.initials: Y
authors.lastname: Herabutya
authors.forename: C
authors.initials: C
authors.lastname: Suchatwatnachai
authors.forename: P
authors.initials: P
authors.lastname: O-Prasertsawat
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D001034:Apgar Score; D002585:Cesarean Section / Q000706:statistics & numerical data; D004359:Drug Therapy, Combination; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D010121:Oxytocin / Q000008:administration & dosage* / Q000627:therapeutic use; D011247:Pregnancy; D011446:Prospective Studies; D011458:Prostaglandins E / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D011458:Prostaglandins E; D010121:Oxytocin