In vivo inactivation of transglutaminase during the acute acrylamide toxic syndrome in the rat.
The activity of liver and brain transglutaminase is rapidly lost following i.p. injection of acrylamide (50-200 mg/kg). Other enzymes investigated were not modified by the treatment, with the exception of brain enolase.
Bergamini
C M
CM
Institute of Biological Chemistry, University of Ferrara, Italy.
Signorini
M
M
D000178:Acrylamides / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011503:Transglutaminases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000178:Acrylamides; D011503:Transglutaminases