[The effect of pH and amount of antacids on bile acid binding in a quasi-natural reflux milieu].
Bile acid adsorption may be one therapeutical mechanism of antacids. Little is known about the effect of pH and amount of antacid on bile acid adsorption. Therefore we carried out the following investigations using a lattice [correction of lettuce] layer antacid as a model substance. 5 ml of "quasi-natural reflux milieu" were mixed with 0.5, 1 or 2 ml of hydrotalcite and adjusted to pH 3, 5 or 7. The highest total bile acid adsorption was found at pH 3, the degree of bile acid adsorption correlated with bile acid lipophilicity, i.e. the most lipophilic and toxic bile acids are adsorbed best. High adsorption of lipophilic and particularly toxic bile acids even at low gastric pH may help to explain the good therapeutic effect of low-dose antacids in gastric ulcer.
Kurtz
W
W
Medizinische Klinik I, Zentralkrankenhaus Reinkenheide, Bremerhaven.
Güldütuna
S
S
Leuschner
U
U
D000327:Adsorption / Q000187:drug effects; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000863:Antacids / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000378:metabolism / Q000493:pharmacokinetics*; D001655:Bile Reflux / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008276:Magnesium Hydroxide / Q000494:pharmacology*
D000863:Antacids; D001647:Bile Acids and Salts; C010467:hydrotalcite; D000536:Aluminum Hydroxide; D008276:Magnesium Hydroxide
Einfluss von pH und Antazidummenge auf die Gallensäurenbindung in quasinatürlichem Refluxmilieu.