Protection by interleukin 1 against lung toxicity caused by cyclophosphamide and irradiation.
Interleukin 1 has been shown to provide protection against the toxic effects of cyclophosphamide given in combination with localized irradiation of the lung. A single dose of 15 micrograms/kg interleukin 1 was given 24 h before cyclophosphamide (25-125 mg/kg) which was followed 1 day later by five daily exposures of 4.5 or 5.0 Gy, localized to the lung. Interleukin 1 significantly reduced early measurements of breathing rate for mice treated with high cyclophosphamide doses and irradiation, and at cyclophosphamide doses above 50 mg/kg, there was a significant reduction in the lethality from the combined treatment. At lower levels of cyclophosphamide, however, there seemed to be no effect.
Dorie
M J
MJ
Department of Radiation Oncology, Stanford University Medical Center, California 94305.
Bedarida
G
G
Kallman
R F
RF
D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity*; D007375:Interleukin-1 / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011829:Radiation Dosage; D011994:Recombinant Proteins
D007375:Interleukin-1; D011994:Recombinant Proteins; D003520:Cyclophosphamide