Microbial O-carbamylation of novobiocin.
Novobiocin was inactivated by Streptomyces niveus US 2094 in fermentation. The inactivation product was isolated and characterized by NMR and MS as 2"-O-carbamylnovobiocin. The MICs of novobiocin and 2"-O-carbamylnovobiocin were determined for S. niveus strains.
Kuo
M S
MS
Upjohn Laboratories, Upjohn Company, Kalamazoo, MI 49001.
Yurek
D A
DA
Chirby
D G
DG
Cialdella
J I
JI
Marshall
V P
VP
D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D004352:Drug Resistance, Microbial / Q000502:physiology*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009675:Novobiocin / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects* / Q000378:metabolism
C071799:2''-O-carbamylnovobiocin; D009675:Novobiocin