Metabolism and disorders of the endocrine pancreas.
The release of insulin evoked by D-glucose and other nutrient secretagogues in the pancreatic B-cell is causally linked to an increase in ATP generation rate. This fuel concept is documented by the higher glycolytic and secretory responses evoked by the alpha-anomer, as distinct from beta-anomer, of either D-glucose or D-mannose. Experimental models of B-cell dysfunction are characterized by several site-specific anomalies in hexose metabolism. For instance, alpha-stereospecificity of the functional response is apparently perturbed in spontaneously diabetic rats or human subjects. Because phosphoglucoisomerase participates in the anomeric specificity of D-glucose metabolism, the intrinsic properties of this enzyme are reevaluated, with emphasis on both the anomeric specificity and discrimination towards hydrogen isotopes as assessed by magnetic resonance imaging.
Malaisse
W J
WJ
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
Willem
R
R
Malaisse-Lagae
F
F
Zähner
D
D
Leclercq-Meyer
V
V
Sener
A
A
D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism*; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism*; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000378:metabolism* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D051381:Rats
D005956:Glucose-6-Phosphate Isomerase