The effect of a standard oral calcium load given in two different forms on plasma ionized calcium and serum PTH.
A standard dose (1 g, 25.4 mmol) of calcium was administered both as calcium chloride in syrup and as Calcium-Sandoz Syrup (calcium glubionate and calcium galactogluconate) to 10 volunteers. Both dosage forms caused a significant rise in ionized calcium and a significant fall in concentration of serum PTH, the calcium chloride producing significantly greater changes. The urinary excretion of calcium measured over 5 h after calcium chloride was double that after Calcium-Sandoz. Calcium chloride, as expected, also gave rise to a decreased urine pH. Calcium chloride would be the better choice for an oral PTH suppression test.
Bailey
I R
IR
Department of Chemical Pathology, St James's University Hospital, Leeds, UK.
D000284:Administration, Oral; D002118:Calcium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002122:Calcium Chloride / Q000008:administration & dosage / Q000493:pharmacokinetics; D002125:Calcium Gluconate / Q000008:administration & dosage / Q000493:pharmacokinetics; D004304:Dosage Forms; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006934:Hypercalcemia / Q000097:blood; D006961:Hyperparathyroidism / Q000097:blood; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D010281:Parathyroid Hormone / Q000097:blood*; D014312:Trisaccharides / Q000008:administration & dosage / Q000493:pharmacokinetics
D004304:Dosage Forms; D009942:Organometallic Compounds; D010281:Parathyroid Hormone; D014312:Trisaccharides; C042131:calcium glubionate; D002122:Calcium Chloride; D002125:Calcium Gluconate; D002118:Calcium