title: Thyroid-stimulating antibody and thyrotropin-binding inhibitory immunoglobulin activity in hypothyroid patients who subsequently developed thyrotoxicosis.
abstract: Although abnormal thyroid-stimulating and -blocking antibodies have been demonstrated in hyperthyroid and hypothyroid patients with autoimmune thyroid disorders, a direct correlation is not always observed. Thyroid-stimulating antibody, thyrotropin-binding inhibitory immunoglobulin, and thyroid-stimulating blocking antibody levels were determined in three hypothyroid patients who subsequently developed hyperthyroidism. Thyroid-stimulating antibodies levels were normal in one, elevated in another, and unmeasured in the third hypothyroid patient, but became elevated in all patients with the onset of hyperthyroidism. There was discordance, however, in one patient who had markedly elevated thyroid-stimulating antibodies and TSH-binding inhibitory immunoglobulin levels when she was hypothyroid. The data indicate that thyroidal responses to the abnormal stimulating antibodies may differ among patients with autoimmune thyroid disease.
authors.affiliation: Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tamai
authors.forename: K
authors.initials: K
authors.lastname: Kasagi
authors.forename: O
authors.initials: O
authors.lastname: Mizuno
authors.forename: N
authors.initials: N
authors.lastname: Kobayashi
authors.forename: G
authors.initials: G
authors.lastname: Komaki
authors.forename: F
authors.initials: F
authors.lastname: Matsuzuka
authors.forename: K
authors.initials: K
authors.lastname: Kuma
authors.forename: J
authors.initials: J
authors.lastname: Konishi
authors.forename: L F
authors.initials: LF
authors.lastname: Kumagai
authors.forename: S
authors.initials: S
authors.lastname: Nagataki
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000378:metabolism*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology / Q000276:immunology*; D007037:Hypothyroidism / Q000188:drug therapy / Q000276:immunology*; D018828:Immunoglobulins, Thyroid-Stimulating; D008297:Male; D008875:Middle Aged; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D013974:Thyroxine