title: Passive protection against infectious bursal disease virus by viral VP2 expressed in yeast.
abstract: Infectious bursal disease virus (IBDV), a pathogen of major economic importance to the world's poultry industries, causes a severe immunodepressive disease in young chickens. Maternal antibodies are able to protect the progeny passively from IBDV infection. The gene encoding the IBDV host-protective antigen (VP2) has been cloned and expressed in yeast resulting in the production of an antigen that very closely resembles native VP2. When injected into specific pathogen free chickens a single dose of microgram quantities of the yeast derived antigen induces high titres of virus neutralizing antibodies that are capable of passively protecting young chickens from infection with IBDV.
authors.affiliation: Division of Biomolecular Engineering, Royal Parade, Parkville, Australia.
authors.forename: I G
authors.initials: IG
authors.lastname: Macreadie
authors.forename: P R
authors.initials: PR
authors.lastname: Vaughan
authors.forename: A J
authors.initials: AJ
authors.lastname: Chapman
authors.forename: N M
authors.initials: NM
authors.lastname: McKern
authors.forename: M N
authors.initials: MN
authors.lastname: Jagadish
authors.forename: H G
authors.initials: HG
authors.lastname: Heine
authors.forename: C W
authors.initials: CW
authors.lastname: Ward
authors.forename: K J
authors.initials: KJ
authors.lastname: Fahey
authors.forename: A A
authors.initials: AA
authors.lastname: Azad
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology; D000956:Antigens, Viral / Q000235:genetics* / Q000276:immunology; D001483:Base Sequence; D002645:Chickens; D004797:Enzyme-Linked Immunosorbent Assay; D015870:Gene Expression; D007106:Immune Sera / Q000276:immunology; D007116:Immunization, Passive; D007243:Infectious bursal disease virus / Q000276:immunology*; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D007106:Immune Sera