Regulation of sulfotransferase activity by vitamin K in mouse brain.
We have shown previously that the administration of warfarin to 16-day-old mice results in a significant reduction in levels of sulfatides, and to a lesser degree a reduction of other sphingolipids in brain. Vitamin K stimulates biosynthesis of sulfatides in warfarin-treated mice. We now report that warfarin inhibits brain sulfotransferase activity. This inhibition is reversed by vitamin K. The treatment of normal mice with vitamin K stimulates the activities of sulfotransferase and arylsulfatase and the turnover rate of brain sulfatides. The ability of vitamin K to influence the activity of biosynthetic and catabolic enzymes and the turnover of sulfatides suggests a possible regulatory role for vitamin K in the maturing brain.
Sundaram
K S
KS
Department of Microbiology, CUNY Medical School, New York 10031.
Lev
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002553:Cerebroside-Sulfatase / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012016:Reference Values; D015238:Sulfotransferases; D013466:Sulfurtransferases / Q000378:metabolism*; D014812:Vitamin K / Q000494:pharmacology*; D014859:Warfarin / Q000494:pharmacology*
D014812:Vitamin K; D014859:Warfarin; D013466:Sulfurtransferases; D015238:Sulfotransferases; C020556:galactosylceramide sulfotransferase; D002553:Cerebroside-Sulfatase