title: Estradiol dependence of the specific mammary tissue targeting of polyoma virus oncogenicity in nude mice.
abstract: We have previously reported (Berebbi et al., 1988) that in athymic nude mice, Polyoma virus induces mammary adenocarcinomas (MAC) at high frequency and exclusively in females. In the present study we show that in nude mice: (1) Ovariectomy results in a reduced frequency of MAC and a longer latency period of induction. When testosterone is administered to ovariectomized females, tumor induction is drastically reduced. (2) When estradiol is administered continuously to ovariectomized females the incidence and kinetics of MAC induction are the same as in control females. (3) MAC are induced in castrated males administered with estradiol although only osteosarcomas are observed in control males. (4) The tumor cells are found to harbor functional estradiol and progesterone receptors. (5) MAC can be transplanted from females to males, indicating that tumor growth is estradiol independent. (6) Estradiol is required only between day 10 and day 20 following polyoma injection, whereas the first tumors are detected only around day 60. Our results indicate that MAC induction by Polyoma virus in nude mice is estradiol-dependent during a short initiation period and that tumor progression is estradiol-independent in spite of the fact tumor cells carry functional estradiol and progesterone receptors.
authors.affiliation: J.E. CNRS, Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Berebbi
authors.forename: P M
authors.initials: PM
authors.lastname: Martin
authors.forename: Y
authors.initials: Y
authors.lastname: Berthois
authors.forename: A M
authors.initials: AM
authors.lastname: Bernard
authors.forename: D
authors.initials: D
authors.lastname: Blangy
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000382:microbiology*; D051379:Mice; D008819:Mice, Nude; D010052:Ovariectomy; D011120:Polyomavirus / Q000472:pathogenicity*; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000032:analysis / Q000235:genetics*; D011519:Proto-Oncogenes / Q000187:drug effects; D018719:Erb-b2 Receptor Tyrosine Kinases
chemical_list: D004958:Estradiol; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases