title: Use of luteinizing-hormone-releasing hormone nasal spray in the treatment of cryptorchidism: is there still an indication? A clinical study in 78 boys with 103 undescended testicles.
abstract: We treated 78 boys with 103 undescended testicles with luteinizing-hormone-releasing hormone (LHRH) nasal spray, 400 micrograms 3 times daily for 4 weeks. After one (28 testicles) or two (5 testicles) courses of LHRH, 33 testicles in 25 boys were in the normal scrotal position. The success rate is 32%. In 41 testicles (40%) the result was a better mobility and/or a further descent, facilitating the proper diagnosis or the operation. 70 testicles were operated, and anatomic abnormalities were seen 37 times. In 6 boys minor side effects were noted. Reviewing the literature there is agreement that LHRH spray sometimes is necessary to confirm the presence of a retractile testicle, and so can be used in trying to avoid an operation.
authors.affiliation: Department of Urology, St. Radboud University Hospital, Nijmegen, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Witjes
authors.forename: J D
authors.initials: JD
authors.lastname: de Vries
authors.forename: M T
authors.initials: MT
authors.lastname: Lock
authors.forename: F M
authors.initials: FM
authors.lastname: Debruyne
mesh_terms: D000281:Administration, Intranasal; D002648:Child; D003131:Combined Modality Therapy; D003456:Cryptorchidism / Q000188:drug therapy* / Q000601:surgery; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male
chemical_list: D007987:Gonadotropin-Releasing Hormone