title: [Penile lesions induced by human papillomavirus. An immunohistochemical study and DNA hybridization].
abstract: Forty-nine male patients with clinically evident genital warts or suspected HPV-induced lesions detected by 5% acetic acid test were biopsied. Typical cytological and structural HPV-induced changes were observed on histological examination in 37 of 49 patients. The immunohistochemical detection of HPV capsid antigen was positive in 15 of 45 cases. In situ HPV-DNA hybridization was positive in 26 of 47 cases (24 HPV 6/11; 2 HPV 16/18). Quick blot HPV-DNA hybridization was positive in 20 of 28 cases (17 HPV 6/11 of which one positive for both HPV 6/11 and 31/33/35; 1 HPV 16/18; 2 cases positive for HPV detection, but not typed for HPV 6/11, 16/18, 31/33/35). Characteristics and use of histopathologic, immunohistochemical and HPV-DNA hybridization methods are analyzed and compared.
authors.affiliation: IRCCS Policlinico San Matteo, Università degli Studi di Pavia.
authors.forename: G
authors.initials: G
authors.lastname: Caresana
authors.forename: P
authors.initials: P
authors.lastname: Tenti
authors.forename: A
authors.initials: A
authors.lastname: Di Matteo
authors.forename: A
authors.initials: A
authors.lastname: Aguzzi
authors.forename: C
authors.initials: C
authors.lastname: Del Forno
mesh_terms: D000956:Antigens, Viral / Q000032:analysis; D002213:Capsid / Q000276:immunology; D003218:Condylomata Acuminata / Q000175:diagnosis*; D015344:DNA Probes, HPV; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D027383:Papillomaviridae / Q000276:immunology; D010412:Penile Neoplasms / Q000175:diagnosis*
chemical_list: D000956:Antigens, Viral; D015344:DNA Probes, HPV
vernacular_title: Lesioni peniene da papillomavirus umano. Studio immunoistochimico e con ibridazione del DNA.