The effects of stimulation of the A5 region on blood pressure and heart rate in rabbits.
The effects of stimulation of the A5 cell group of the caudal ventrolateral pons electrically or with L-glutamate on heart rate and blood pressure were determined in rabbits. Electrical stimulation caused blood pressure increases and reflex bradycardia. L-glutamate caused decreases in blood pressure and heart rate which were blocked by the L-glutamate antagonist aminophosphoheptanoic acid. Transection of the brainstem at the level of the midbrain did not alter the effects of either electrical or chemical stimulation. Lesions of the nucleus and tractus solitarius (NTS) attenuated the effects of L-glutamate, but did not change the effectiveness of electrical stimulation. Injections of 6-hydroxydopamine three to four weeks before the experiments blocked the effects of electrical stimulation but only reduced the effects of L-glutamate injection. The A5 group may have two functional subdivisions. Some A5 cells may produce blood pressure depressor and bradycardic effects by means of projections to the NTS and the spinal cord. Other A5 cells may produce blood pressure pressor effects by means of projections to the spinal cord.
Drye
R G
RG
Department of Anatomy, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614.
Baisden
R H
RH
Whittington
D L
DL
Woodruff
M L
ML
D000818:Animals; D001794:Blood Pressure; D002320:Cardiovascular Physiological Phenomena; D004558:Electric Stimulation; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D006339:Heart Rate; D006892:Hydroxydopamines; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology; D016627:Oxidopamine; D011149:Pons / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits
D005971:Glutamates; D006892:Hydroxydopamines; D018698:Glutamic Acid; D016627:Oxidopamine