title: Pleiotropic effects of positively charged liposomes on immune functions.
abstract: Positively charged liposomes have been shown to inhibit the proliferation of lymphocytes induced by various polyclonal activators. We demonstrated that this inhibition is essentially restricted to early phases of activation. B cell proliferation, induction of suppressor cells, and cytotoxic activities are all profoundly inhibited, whereas T4+ cells response to mitogenic stimulation is only moderately affected. The results are discussed in terms of membrane perturbations potentially induced by liposome-lymphocyte interactions.
authors.affiliation: Département Chimie-Biologie, Université du Québec à Trois-Rivières, Canada.
authors.forename: H M
authors.initials: HM
authors.lastname: Thérien
authors.forename: J
authors.initials: J
authors.lastname: Gruda
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D004553:Electric Conductivity; D006801:Humans; D008081:Liposomes / Q000494:pharmacology*; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D008081:Liposomes; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A