Serotonin reuptake inhibitors, epilepsy and myoclonus.
Specific inhibitors of 5-HT reuptake are reported to have lower proconvulsive activity than other antidepressants. A patient with post-traumatic epilepsy who had remained fit-free for many years until she was given the 5-HT reuptake inhibitor fluvoxamine is reported. Changes in serotonergic function may play a more widespread role in the pathophysiology of seizure disorders than hitherto thought.
Deahl
M
M
Medical College of St Bartholomew's Hospital, West Smithfield, London.
Trimble
M
M
D001921:Brain / Q000187:drug effects; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004569:Electroencephalography / Q000187:drug effects; D004829:Epilepsy, Generalized / Q000139:chemically induced* / Q000175:diagnosis; D004834:Epilepsy, Post-Traumatic / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D016666:Fluvoxamine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009207:Myoclonus / Q000139:chemically induced* / Q000175:diagnosis; D011985:Receptors, Serotonin / Q000187:drug effects
D011985:Receptors, Serotonin; D016666:Fluvoxamine