Results of a clinical and pharmacokinetic study of ceftazidime in patients with postoperative pneumonia on assisted ventilation.
Thirty-three patients who developed nosocomial pneumonia postoperatively were treated with ceftazidime, 4-6 g daily, over an average period of 7 days. Twenty-nine patients were evaluated; 13 (45%) patients were cured, five showed improvement, two relapsed, and one could not be assessed. X-rays of the chest showed no infiltrates in 17 out of the 29 cases (59%) after treatment. On the first day of treatment, ceftazidime concentrations in bronchial secretions of nine patients were estimated. The mean values of serum concentrations were: 15 min after infusion, 98 micrograms ml-1; 60 min, 63; 120 min, 44; 360 min, 20; 480 min, 13 micrograms ml-1. The mean values of the corresponding bronchial secretions were 2.9, 5.8, 10.2, 7.11 and 5.2 micrograms ml-1.
Erttmann
M
M
Abt. Allgemeine Chirurgie, Klinikum der Universität Kiel, F. R. Germany.
Ullmann
U
U
Koch
E M
EM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002442:Ceftazidime / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003428:Cross Infection / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D011183:Postoperative Complications / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D011446:Prospective Studies; D012121:Respiration, Artificial; D013183:Sputum / Q000032:analysis
D002442:Ceftazidime