Evaluation of the carcinogenic potential of pesticides. 3. Aliette.
Aliette, a fungicide compound, was evaluated for carcinogenic potential by the Health Effects Division of the Office of Pesticide Programs using a consensus peer review process and EPA's guidelines for risk assessment. Aliette was categorized as a group C (possible human) carcinogen based upon evidence of an increased incidence of combined benign and malignant urinary bladder tumors in a single study involving male Charles River (CR) CD rats. The bladder tumors occurred only at the unusually high top dose level of aliette that was tested (40,000/30,000 ppm). The compound was not carcinogenic in female CR-CD rats in the same study, or in CD-1 mice of either sex in a second study. Monosodium phosphite, the main urinary metabolite of aliette, was also not carcinogenic in male or female CR-CD rats. Aliette was not demonstrated to be genotoxic. No structural analogues of aliette were identified. The mechanism of action for the production of bladder tumors was not identified; however, it did not appear to involve a genotoxic effect, a carcinogenic effect of metabolites, or the formation of renal stones. The data were not found to be sufficient to quantify human cancer risk from aliette.
Quest
J A
JA
Health Effects Division, U.S. Environmental Protection Agency, Washington, D.C. 20460.
Hamernik
K L
KL
Engler
R
R
Burnam
W L
WL
Fenner-Crisp
P A
PA
D000310:Adrenal Gland Neoplasms / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D005659:Fungicides, Industrial / Q000633:toxicity*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity; D009943:Organophosphorus Compounds / Q000633:toxicity*; D051381:Rats; D013329:Structure-Activity Relationship; D014481:United States; D014484:United States Environmental Protection Agency; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D005659:Fungicides, Industrial; D009153:Mutagens; D009943:Organophosphorus Compounds; C053504:fosetyl-Al