[Pharmacokinetics of human milk lactoferrin in intact mice and tumor-carrying animals].
Pharmacokinetics of iodine containing and native lactoferrin from human milk was studied in intact mice and the animals with Ehrlich ascites carcinoma. Both these antigens, native and I-lactoferrin, were similarly distributed in intact mice body. The same pharmacokinetics was found in tumor-bearing animals. Exogenous lactoferrin penetrated mainly into liver tissue, then simultaneously with bile--into small intestine and further into large intestine. Distinct accumulation of the glycoprotein was not found in tumor tissue.
Kazachkina
N I
NI
Nemtsova
E R
ER
Iakubovskaia
R I
RI
Karmakova
T A
TA
Ivanova
L M
LM
Sokolov
A V
AV
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D005260:Female; D007421:Intestine, Small / Q000378:metabolism; D007781:Lactoferrin / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008892:Milk
D007781:Lactoferrin
Izuchenie farmakokinetiki laktoferrina zhenskogo moloka u intaktnykh mysheĭ i zhivotnykh-opukholenositeleĭ.