[Comparative evaluation of anticonvulsant and anti-arrhythmic effects of phenazepam, a benzodiazepine receptor agonist].
It was established on white mice that benzodiazepine receptor agonist phenazepam possessed a high anticonvulsant activity to antagonize bicuculline, corrasol, picrotoxin and thiosemicarbazide. It was also shown that phenazepam had a potent antiarrhythmic effect on ischemic and reperfusion cardiac arrhythmias in Wistar rats in situ. The effect was of a central nature since it was irreproducible in isolated heart. It seems to be due to the potentiating effect of phenazepam on the realization of GABA inhibitory control of centers of the heart regulation. The facts obtained evidence a possibility of using phenazepam not only as an anticonvulsant but also as an antiarrhythmic means.
Voronina
T A
TA
Meerson
F Z
FZ
Mdzinarishvili
A L
AL
Abdikaliev
N A
NA
Pshennikova
M G
MG
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D001640:Bicuculline / Q000037:antagonists & inhibitors; D006321:Heart / Q000187:drug effects; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010852:Picrotoxin / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013882:Thiosemicarbazones / Q000037:antagonists & inhibitors
D014151:Anti-Anxiety Agents; D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D001569:Benzodiazepines; D001570:Benzodiazepinones; D001640:Bicuculline; D010433:Pentylenetetrazole; D010852:Picrotoxin; D013882:Thiosemicarbazones; C017928:phenazepam
Sravnitel'naia otsenka protivosudorozhnogo i antiaritmicheskogo éffektov agonista benzodiazepinovykh retseptorov fenazepama.