title: [The effect of the hypercalcaemia on the major salivary glands of the rat].
abstract: Although hypercalcaemia is considered to be aetiological factor of nephrocalcinosis and uroliths formation, its effect on the major salivary glands, where lithiasis is frequent, has not been studied enough. The purpose of this project was the parallel histologic study of the effect of experimentally induced hypercalcaemia on the kidney and the major salivary glands of the rat. Temporary hypercalcaemia was induced in 17 females rates after 8 daily intraperitoneal doses 1.5 ml of 10% calcium gluconate. After the fixation of the tissues in 4% formaldehyde containing 1% CaCl2, serial sections were stained with haematoxylin and eosin and Von Kossa's method for calcified deposits. In the kidneys calcified deposits were observed in the cytoplasm of the cells of the proximal convoluted tubules, in the basement membrane, and their lumen. The major salivary glands were normal. Calcified deposits were not observed in the glandular parenchyma either in the lumina. The results suggest that during hypercalcaemia the transcellular transport of the calcium continue to be under the normal influence of the autonomic nervous system, preventing the formation of calcified deposits.
authors.forename: A
authors.initials: A
authors.lastname: Epivatianos
authors.forename: M
authors.initials: M
authors.lastname: Tsougas
mesh_terms: D000818:Animals; D002125:Calcium Gluconate / Q000009:adverse effects*; D005260:Female; D009397:Nephrocalcinosis / Q000139:chemically induced; D051381:Rats; D011920:Rats, Inbred WF; D015494:Salivary Gland Calculi / Q000139:chemically induced*
chemical_list: D002125:Calcium Gluconate
vernacular_title: E epidrase tes hyperasbestiaimias stous megalous sialogonous adenes. Peiramatike melete se epimys.