Cornexistin: a new fungal metabolite with herbicidal activity.
Cornexistin, a new compound demonstrating promising herbicidal activity, was purified from the culture filtrate of a newly-isolated fungus identified as Paecilomyces variotii SANK 21086. The compound was extracted with organic solvents from the culture filtrate, purified using column chromatography on Sephadex LH-20 and finally crystallized from methylene chloride. Following analysis of its physico-chemical properties it was identified to be a new compound belonging to the nonadride group. Chemical structure elucidation was conducted by analyses of various spectral data and the structure was finally confirmed by means of X-ray crystallographic analysis. Based on its herbicidal characteristics cornexistin may be classified as a postemergence herbicide active against certain young annual and perennial monocotyledonous and dicotyledonous plants with selective protection for corn.
Nakajima
M
M
Fermentation Research Laboratories, Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Itoi
K
K
Takamatsu
Y
Y
Sato
S
S
Furukawa
Y
Y
Furuya
K
K
Honma
T
T
Kadotani
J
J
Kozasa
M
M
Haneishi
T
T
D002845:Chromatography; D003460:Crystallization; D005285:Fermentation; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D006540:Herbicides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D015394:Molecular Structure; D010143:Paecilomyces / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D010944:Plants / Q000187:drug effects*; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D005663:Furans; D006540:Herbicides; C071795:cornexistin