[The participation of transmembrane messenger systems in the action of steroid hormones on target cells].
Estradiol receptors are discovered in nuclei, cytoplasm and plasmatic membranes of the target cells. Estradiol activates the transmembrane polyphosphoinositide system: it stimulates the protein kinase C translocation from cytosol to cell membranes, the membrane protein phosphorylation being elevated. Transmembrane adenylate cyclase system is also activated. The cAMP system stimulation by estradiol is mediated by protein kinase C, phosphorylating a protein of adenylate cyclase complex. Estradiol causes protein kinases A translocation into the cell nuclei and enhances the protein kinase NII activity. The role of protein phosphorylation, activated by steroid hormones, in the transcription and protein synthesis regulation, is discussed.
Morozova
T M
TM
Levashova
Z B
ZB
Nagibneva
I N
IN
Rau
V A
VA
Sidorkina
O M
OM
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006728:Hormones / Q000502:physiology*; D010716:Phosphatidylinositols / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology; D011959:Receptors, Estradiol / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology*
D006728:Hormones; D010716:Phosphatidylinositols; D011956:Receptors, Cell Surface; D011959:Receptors, Estradiol; D004958:Estradiol; D011494:Protein Kinases; D000262:Adenylyl Cyclases
Uchastie transmembrannykh sistem posrednikov v deĭstvii steroidnykh gormonov na kletki-misheni.