title: [Compounds similar to acyclovir. VII. Attempts to construct an anti-herpetic agent (6-hydroxy-2-oxa-4-hexenyl derivatives of nucleic bases].
abstract: Based on the available data on the acyclovir's mechanism of action we attempted to predict the antiherpetic activity of 6-hydroxy-2-oxahexen-4-yl derivatives of nucleic bases. In terms of this model 9-(6-hydroxy-2-oxahexen-4-yl) guanine might be active. 6-Hydroxy-2-oxahexen-4-yl derivatives of adenine, guanine, cytosine, thymine, uracil, 1,2,4-triazole-3 and 1,2,4-triazole-5-carboxamide have been synthesized and their activity against herpes virus I investigated. The guanine derivative proved to possess rather high activity (chemotherapeutical index 8).
authors.forename: S V
authors.initials: SV
authors.lastname: Kochetkova
authors.forename: T L
authors.initials: TL
authors.lastname: Tsilevich
authors.forename: G V
authors.initials: GV
authors.lastname: Vladyko
authors.forename: L V
authors.initials: LV
authors.lastname: Korobchenko
authors.forename: E I
authors.initials: EI
authors.lastname: Boreko
authors.forename: I P
authors.initials: IP
authors.lastname: Smirnov
authors.forename: A A
authors.initials: AA
authors.lastname: Khorlin
authors.forename: B P
authors.initials: BP
authors.lastname: Gottikh
authors.forename: V L
authors.initials: VL
authors.lastname: Florent'ev
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008958:Models, Molecular; D018139:Simplexvirus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000212:Acyclovir
vernacular_title: Soedineniia, podobnye atsikloviru. VII. Popytka konstruirovaniia protivogerpeticheskogo preparata (6-gidroksi-2-oksa-4-geksenil'nye proizvodnye nukleinovykh osnovaniĭ.