title: Simultaneous occurrence of calcification and amyloid deposit in pilomatricoma.
abstract: Amyloid deposition was encountered in 10 of 16 samples of pilomatricoma, indicating that the deposition of amyloid is nearly as common as calcification in pilomatricoma. In addition, a simultaneous occurrence of calcification and amyloid deposit in pilomatricoma was recognized in 9 of 16 samples. The calcification and the deposition of amyloid developed topographically in the same area within the shadow cell masses. Such an area was revealed as moderately basophilic, amorphous, or hyalinized by H&E staining. Electron microscopy revealed spotty calcium deposits in amyloid. No light chains of human immunoglobulin were detected in the amyloid-deposited area. Amyloid in this tumour may facilitate calcification or serve as a matrix for subsequent calcification.
authors.affiliation: Department of Dermatology, Tottori University School of Medicine, Yonago, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sano
authors.forename: M
authors.initials: M
authors.lastname: Mihara
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
authors.forename: S
authors.initials: S
authors.lastname: Shimao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000682:Amyloid / Q000032:analysis*; D002114:Calcinosis / Q000378:metabolism / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D000682:Amyloid