Membrane-bound phospholipase C activity in normal and psoriatic epidermis.
We report the quantification of a membrane-bound phospholipase C in human epidermis which is active against the physiologically relevant substrate, phosphatidylinositol 4,5-bisphosphate. The level of this enzyme is significantly increased in the psoriatic lesion, both on a weight and protein basis. Etiological implications of this observation are discussed.
Bergers
M
M
Department of Dermatology, University Hospital, Nijmegen, The Netherlands.
van de Kerkhof
P C
PC
Happle
R
R
Mier
P D
PD
D001706:Biopsy; D004817:Epidermis / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000037:antagonists & inhibitors; D011565:Psoriasis / Q000201:enzymology*; D010738:Type C Phospholipases / Q000032:analysis / Q000378:metabolism*
D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D010738:Type C Phospholipases