The dopaminergic actions of B-HT 920.
B-HT 920 (2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo-[4,5-d]-azepine), an alpha 2-adrenoceptor agonist has been reported to modulate dopamine (DA) receptor activity. Earlier studies speculated the DA autoreceptor action of B-HT 920. However, some recent studies have indicated that the stimulatory effects of B-HT 920 are sensitive to blockade by sulpiride and haloperidol, suggesting a postsynaptic D2-dopamine receptor action. The article briefly reviews the current concepts about DAergic actions of B-HT 920.
Kulkarni
S K
SK
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Chopra
K
K
D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D015259:Dopamine Agents / Q000494:pharmacology*; D006801:Humans; D011954:Receptors, Dopamine / Q000187:drug effects
D001381:Azepines; D015259:Dopamine Agents; D011954:Receptors, Dopamine; C024763:talipexole