Separation of hydroxyquinolines by high-performance liquid chromatography.
1. Hydroxyquinolines are important chemicals for pharmaceutical and cosmetic use. This report describes an improved method for separating these chemicals, by utilizing a high-performance liquid chromatography technique. 2. 8-Hydroxyquinoline is an excellent chelating agent. Previous separation procedures failed because of this property. An important requirement for the success of the method described is to provide a metal-free environment for the separation of hydroxyquinolines by replacing metal tubing with Polyplex and polyether-ether ketone (PEEK) tubing and utilizing a metal-free Hamilton PRP-1 column.
Nagiel-Ostaszewski
I
I
American Health Foundation, Valhalla, New York 10595-1599.
Vavrek
M T
MT
Weisburger
J H
JH
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006912:Hydroxyquinolines / Q000302:isolation & purification*; D011804:Quinolines / Q000302:isolation & purification; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D006912:Hydroxyquinolines; D011804:Quinolines; C037219:quinoline