A centromere map of the X chromosome from trisomies of maternal origin.
A centromere map is derived from XXX and XXY trisomies of maternal origin. Preliminary data suggest reduced recombination in the tetrads giving rise to mei I nondisjunction, but an excess of recombination in the pericentric region. As in Drosophila, multichiasmate tetrads may be more at risk of nondisjunction than nullochiasmate tetrads.
Morton
N E
NE
CRC Research Group in Genetic Epidemiology, Department of Community Medicine, Southhampton General Hospital, UK.
Keats
B J
BJ
Jacobs
P A
PA
Hassold
T
T
Pettay
D
D
Harvey
J
J
Andrews
V
V
D000818:Animals; D002503:Centromere; D002875:Chromosomes; D003434:Crossing Over, Genetic; D004331:Drosophila melanogaster; D005260:Female; D006801:Humans; D009035:Mothers; D012150:Polymorphism, Restriction Fragment Length; D014314:Trisomy; D014960:X Chromosome