[Correlation of viral replication activity, the clinical phase of the disease and immunologic deterioration in HIV infection].
The authors have studied the relationship among HIV replicative activity, expressed by HIV isolation from peripheral blood lymphocytes and p24 antigenemia detection, and the evolution of infection, in terms of stage of disease and T4 cells absolute number, in a group of 120 infected subjects. Data presented indicate that the expression of viral gene products is related both to clinical and immunological deterioration and suggest that viral replication plays a central role in the progression of the disease.
Fico
C
C
Clinica di Malattie Infettive, Università di Bari.
Angarano
G
G
Fiore
J R
JR
Casalino
C
C
Salamina
G F
GF
Pastore
G
G
D000386:AIDS-Related Complex / Q000097:blood / Q000503:physiopathology; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000503:physiopathology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006679:HIV Seropositivity / Q000097:blood / Q000503:physiopathology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007958:Leukocyte Count; D014779:Virus Replication / Q000502:physiology*
Correlazioni tra attività replicativa virale, stadio clinico di malattia e deterioramento immunologico nelle infezioni da HIV.