title: Epileptic patients refractory to drug therapy.
abstract: We compared two groups of patients with idiopathic epilepsy, 41 patients whose seizure frequency was not controlled by adequate therapy and 39 patients in good seizure control, in respect of hematology, kidney and liver function tests, serum IgG, IgA and IgM concentrations and drug concentrations. The only difference that emerged were in the serum immunoglobulins, which were raised in the drug refractory group, significantly (p less than 0.01) so in the case of IgG. Failure of seizure control did not depend on inadequacy of drug dose or of blood concentration. Although the serum Ig changes do not warrant the assumption of an immunological origin for drug resistance, they do suggest a useful research line.
authors.affiliation: Laboratorio di Biochimica Clinica, Istituto Superiore di Sanità, Roma.
authors.forename: L
authors.initials: L
authors.lastname: Paris
authors.forename: M
authors.initials: M
authors.lastname: Giardina
authors.forename: R
authors.initials: R
authors.lastname: Pacifici
authors.forename: S
authors.initials: S
authors.lastname: Pichini
authors.forename: P
authors.initials: P
authors.lastname: Zuccaro
authors.forename: G
authors.initials: G
authors.lastname: Sideri
mesh_terms: D000328:Adult; D002220:Carbamazepine / Q000097:blood / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000097:blood / Q000627:therapeutic use; D010672:Phenytoin / Q000097:blood / Q000627:therapeutic use; D014635:Valproic Acid / Q000097:blood / Q000627:therapeutic use
chemical_list: D007074:Immunoglobulin G; D007136:Immunoglobulins; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D010634:Phenobarbital