Treatment of latent rabbit and human papillomavirus infections with 9-(2-phosphonylmethoxy)ethylguanine (PMEG).
The acyclic nucleotide PMEG was studied for effectiveness against Shope papillomavirus (CRPV) infection of rabbits and human papillomavirus type 11 (HPV-11) infections of human foreskin xenografts in athymic mice. PMEG given in the latent period strongly suppressed the subsequent growth rates of Shope papillomas. PMEG starting in the latent period and continuing for the duration of the experiment, inhibited HPV-11 infections of human skin, including condyloma growth, and synthesis of viral DNA and capsid antigen. Drug toxicity paralleled the therapeutic effects in rabbits but there was much less toxicity in athymic mice.
Kreider
J W
JW
Department of Pathology, Milton S. Hershey Medical Center, Hershey, PA 17033.
Balogh
K
K
Olson
R O
RO
Martin
J C
JC
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002213:Capsid / Q000276:immunology; D004279:DNA, Viral / Q000096:biosynthesis; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D027383:Papillomaviridae / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D011817:Rabbits; D014412:Tumor Virus Infections / Q000188:drug therapy*
D000956:Antigens, Viral; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004279:DNA, Viral; D009943:Organophosphorus Compounds; C063380:9-((2-phosphonylmethoxy)ethyl)guanine; D006147:Guanine