[A control study of some hair trace elements content of schizophrenics before and after treatment].
This is a comparative survey of hair trace elements of 69 schizophrenics matched with normals, the result of which is summarized as follows: It was found that the hair Cu Fe Mg in all patients and Mn in females had significantly lower quantities than normals, in addition to which no significant difference of CU/ZN ratio was found between the patients and the normals and there were no significant differences of hair Cu Fe Mn Zn Mg in schizophrenics before and after chlorpromazine treatment. The hair Fe Mn in recovered group were significantly higher than the improved group, it was probably related to the former had more patients with extrapyramidal symptoms than the later. That was coincident with the hair Fe was increased significantly in the patients with extrapyramidal symptoms of study group after Chlorpromazine treatment. The authors suggest the need for further study on the theory of Parkinson-like Syndrome could probably be related to free-radical formation.
Luo
S
S
Hunan Provinical Mental Hospital, Changsha.
D000293:Adolescent; D000328:Adult; D002746:Chlorpromazine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism*; D014131:Trace Elements / Q000032:analysis*
D014131:Trace Elements; D002746:Chlorpromazine