Ketorolac versus DHE and metoclopramide in the treatment of migraine headaches.
Ketorolac IM was compared to DHE and metoclopramide IV in migraine patients whose regular abortive medication had failed and who presented to a headache clinic for acute treatment. Pain scale ratings and ratings of ability to function were recorded before and after injection. Ketorolac provided moderate relief in headache in six of nine patients compared to eight of nine given DHE and metoclopramide. The average improvement in patients receiving DHE and metoclopramide was greater in pain (p = .031) and disability scores (p = .057), than in those patients given ketorolac.
Klapper
J A
JA
Colorado Neurology and Headache Center, Denver 80218.
Stanton
J S
JS
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004087:Dihydroergotamine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D020910:Ketorolac; D008787:Metoclopramide / Q000627:therapeutic use*; D008881:Migraine Disorders / Q000188:drug therapy*; D014046:Tolmetin / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004087:Dihydroergotamine; D014046:Tolmetin; D008787:Metoclopramide; D020910:Ketorolac