[Studies on pyridonecarboxylic acids as anti-bacterial agents. IX. Study on prodrugs of some pyridonecarboxylic acids].
Synthesis and antibacterial activity of pivaloyloxymethyl esters of norfloxacin, ciprofloxacin and their N-substituted derivatives are reported. In vivo antibacterial activities (ED50) of IIIAa, b, e; IIIBa, e; IVA and IVB were 2.30, 8.48, 4.28, 2.77, 4.46, 5.68 and 0.75 (mg/kg) respectively.
Li
Z R
ZR
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing.
Guo
H Y
HY
Zhang
Z P
ZP
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D002939:Ciprofloxacin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D004927:Escherichia coli Infections / Q000188:drug therapy; D051379:Mice; D009643:Norfloxacin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D011355:Prodrugs / Q000138:chemical synthesis*
D000890:Anti-Infective Agents; D011355:Prodrugs; D002939:Ciprofloxacin; D009643:Norfloxacin