[Rabbit osteosarcoma induced by hydroxypropylcellulose mixed beryllium oxide pellet--comparison between implantations into bone marrow cavity and into fracture callus of the femur].
Hydroxypropylcellulose mixed beryllium oxide pellets were implanted into the distal metaphysis in the right femurs of 30 rabbits (3 groups, 10 rabbits each): in Group 1 into the internal callus 1 week after production of artificial fracture at a dose of 300 mg, in Group 2 into the bone marrow cavity at a dose of 300 mg, and in Group 3 into the bone marrow cavity at a dose of 50 mg. Osteosarcoma was induced in all of 10 rabbits in Group 1, 7 out of 10 in Group 2, 1 out of 10 in Group 3 at 56 weeks after implantation of BeO. In Group 1, the emergence of tumor and the increase of serum alkaline phosphatase appeared significantly earlier and 80% of the animals with osteosarcoma showed lung metastasis. This experimental method, especially that used in group 1, appears to be useful for the study of human osteosarcoma.
Hiruma
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Department of Orthopedic Surgery, Yokohama City University School of Medicine, Kanagawa, Japan.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001608:Beryllium; D014408:Biomarkers, Tumor / Q000097:blood; D001853:Bone Marrow; D001859:Bone Neoplasms / Q000139:chemically induced* / Q000473:pathology; D002146:Bony Callus / Q000473:pathology; D002482:Cellulose / Q000031:analogs & derivatives; D004195:Disease Models, Animal; D004343:Drug Implants; D005264:Femoral Fractures / Q000473:pathology; D005269:Femur; D008175:Lung Neoplasms / Q000139:chemically induced / Q000556:secondary; D008297:Male; D012516:Osteosarcoma / Q000139:chemically induced* / Q000473:pathology / Q000556:secondary; D011817:Rabbits
D014408:Biomarkers, Tumor; D004343:Drug Implants; C032777:beryllium oxide; D002482:Cellulose; C008079:hydroxypropylcellulose; D000469:Alkaline Phosphatase; D001608:Beryllium