title: The G protein connection: molecular basis of membrane association.
abstract: Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.
authors.affiliation: Molecular Pathophysiology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
authors.forename: A M
authors.initials: AM
authors.lastname: Spiegel
authors.forename: P S
authors.initials: PS
authors.lastname: Backlund
authors.forename: J E
authors.initials: JE
authors.lastname: Butrynski
authors.forename: T L
authors.initials: TL
authors.lastname: Jones
authors.forename: W F
authors.initials: WF
authors.lastname: Simonds
mesh_terms: D000595:Amino Acid Sequence; D002070:Butadienes / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism*; D045782:Hemiterpenes; D008563:Membrane Lipids / Q000378:metabolism*; D008969:Molecular Sequence Data; D019814:Myristic Acid; D009227:Myristic Acids / Q000378:metabolism; D010420:Pentanes
chemical_list: D002070:Butadienes; D045782:Hemiterpenes; D008563:Membrane Lipids; D009227:Myristic Acids; D010420:Pentanes; C005059:isoprene; D019814:Myristic Acid; D019204:GTP-Binding Proteins