title: Aldehyde reductase is a major protein associated with 3-deoxyglucosone reductase activity in rat, pig and human livers.
abstract: 3-Deoxyglucosone reductase activity in the extracts of rat, pig and human livers was potently inhibited by aldehyde reductase inhibitors. The major species of 3-deoxyglucosone reductase purified from human and pig livers were biochemically and immunochemically identical with aldehyde reductase. The two enzymes and rat liver aldehyde reductase exhibited higher catalytic efficiency for 3-deoxyglucosone than for D-glucuronate, a representative substrate of aldehyde reductase.
authors.affiliation: Department of Biochemistry, Gifu Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kanazu
authors.forename: M
authors.initials: M
authors.lastname: Shinoda
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: Y
authors.initials: Y
authors.lastname: Deyashiki
authors.forename: A
authors.initials: A
authors.lastname: Hara
authors.forename: H
authors.initials: H
authors.lastname: Sawada
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000449:Aldehyde Reductase / Q000378:metabolism*; D000818:Animals; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine
chemical_list: D003847:Deoxyglucose; D000429:Alcohol Oxidoreductases; C019642:alcohol dehydrogenase (NADP+); D000449:Aldehyde Reductase; C016350:3-deoxyglucosone