The effect of clonidine and related substances on voluntary ethanol consumption in rats.
Clonidine, guanfacine and tiamenidine, in equihypotensive doses, significantly reduced alcohol intake in ethanol-preferring rats having free choice between 10% ethanol and drinking water. Water intake was only slightly reduced, especially during the first hours following the administration of clonidine. Simultaneous treatment with yohimbine attenuated the clonidine-induced reduction in ethanol intake. Putative central mechanisms underlying the observed inhibitory actions of clonidine and other alpha-2 adrenoceptor agonists on oral self-administration of alcohol are discussed.
Opitz
K
K
Department of Pharmacology and Toxicology, University of Münster, F.R.G.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000428:Alcohol Drinking / Q000187:drug effects*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D016316:Guanfacine; D006146:Guanidines / Q000494:pharmacology; D010648:Phenylacetates / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013876:Thiophenes / Q000494:pharmacology; D015016:Yohimbine / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D000959:Antihypertensive Agents; D006146:Guanidines; D010648:Phenylacetates; D013876:Thiophenes; C010354:tiamenidine; D015016:Yohimbine; D016316:Guanfacine; D003000:Clonidine