[Pharmacokinetics and metabolism of artesunate in cows].
The pharmacokinetics of artesunate (AS) was studied in 3 cows, single dose of AS (5 mg/kg) were administered intravenously and the drug concentrations were determined by means of a TLC method developed in our laboratory. The plasma drug concentration-time course of AS, after the treatment with a pharmacokinetic microcomputer program MCPKP edited by Wen-Jiang Xia, was found to be best fitted to a two compartment open model and its pharmacokinetic parameters were as follows, T1/2 alpha = 2.43 min, T1/2 beta = 31.45 min, V1 = 0.124 L/kg, VB = 0.937 L/kg, ClB = 0.0215 L/kg. min, AUC = 236 mg/L.min. Dihydroartemisinine (DHA), the main active metabolite of AS in the bodies, was detected simultaneously. Peak plasma concentration of 3.5 micrograms/ml of DHA was reached at about 3 minutes after dosing and the AUC was 82 mg/L.min.
Huo
J Z
JZ
Institute of Traditional Chinese Veterinary Medicine, Chinese Academy of Agricultural Sciences, Lanzhou.
Xia
W J
WJ
Xue
M
M
Zhou
Z T
ZT
D000818:Animals; D037621:Artemisinins; D000077332:Artesunate; D002417:Cattle; D002855:Chromatography, Thin Layer; D005260:Female; D012717:Sesquiterpenes / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*
D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; C039060:artenimol