title: [Determination of tetracyclines by flow injection analysis].
abstract: An accurate, convenient and fast method was proposed for the determination of tetracyclines (tetracycline, chlortetracycline, oxytetracycline, doxycycline and methacycline) and their preparations by flow injection detector based on tetracycline flow-through sensor. The parameters affecting the measurement were discussed. The detector can respond to tetracycline, chlortetracycline, oxytetracycline, doxycycline and methacycline, at the same time. Their slopes are 51-55 mV/decade over the concentration range of 10(-2)-5 x 10(-5) mol/L at pH 1.5-3.5. The results obtained are in good agreement with those by biological assay (less than 3% deviation). One hundred samples can be determined in an hour.
authors.affiliation: Hubei Provincial Institute for Drug Control, Wuhan.
authors.forename: W Z
authors.initials: WZ
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.forename: A Z
authors.initials: AZ
authors.lastname: Du
mesh_terms: D004563:Electrochemistry; D013754:Tetracyclines / Q000032:analysis*
chemical_list: D013754:Tetracyclines