[Peroxide modification of skeletal muscle sarcoplasmic reticulum in antioxidant deficiency and under the effect of ionol. II. Physico- chemical properties of the sarcoplasmic reticulum membrane].
Physico-chemical parameters of membranes of skeletal muscles' sarcoplasmic reticulum in antioxidant insufficiency, which was modelled by excluding alpha-tocopherol from the animals ration, and after treatment with phenol antioxidant ionol were studied. It was shown that activation of lipid peroxidation in vitamin E insufficiency results in a significant lowering of microviscosity of lipid bilayer membranes of sarcoplasmic reticulum. Using polarography significant changes in membrane protein conformation were revealed, which were characterized by lowering of integrity and by disorganization of protein globules. Treatment of animals with antioxidant insufficiency with ionol led to certain normalization of changes of physico-chemical characteristics of the learned membrane structures caused by lipid peroxidation.
Gubskiĭ
Iu I
IuI
Primak
R G
RG
Bodanova
L A
LA
Goriushko
A G
AG
Zadorina
O V
OV
Golubov
M I
MI
D000818:Animals; D000975:Antioxidants; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects; D005260:Female; D008051:Lipid Bilayers; D015227:Lipid Peroxidation; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D010545:Peroxides / Q000494:pharmacology*; D011048:Polarography; D051381:Rats; D011919:Rats, Inbred Strains; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
D000975:Antioxidants; D008051:Lipid Bilayers; D010545:Peroxides; D002084:Butylated Hydroxytoluene
Perekisnaia modifikatsiia sarkoplazmaticheskogo reticuluma skeletnykh myshts pri antiokidantnoĭ nedostatochnosti i deĭstvii ionola. II. Fiziko-khimicheskie kharakteristiki membran sarkoplazmaticheskogo retikuluma.