[Prevention of cAMP stimulation of activity of various oxidative mitochondrial enzymes with lidocaine and aminazine].
Lidocaine or aminazine (chlorpromazine) injected to rats or incubated with liver mitochondria prevented NAD-isocitrate dehydrogenase and transhydrogenase activation during the subsequent incubation of mitochondria with cAMP. Integrity of mitochondrial membranes is obligatory for manifestation of the drugs effect. Lidocaine and aminazine-induced desensitization of mitochondria to the cAMP action was apparently realized via alteration in the state (and/or composition) of lipid component of mitochondria. The significance of mitochondria sensitivity to cAMP stimulation is discussed.
Medvedev
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AE
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D004789:Enzyme Activation; D005260:Female; D007521:Isocitrate Dehydrogenase / Q000378:metabolism*; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology; D009250:NADP Transhydrogenases / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D008012:Lidocaine; D000242:Cyclic AMP; D007521:Isocitrate Dehydrogenase; D009250:NADP Transhydrogenases; D002746:Chlorpromazine
Preduprezhdenie lidokainom i aminazinom tsAMF-zavisimoĭ stimuliatsii aktivnosti nekotorykh okislitel'nykh fermentov mitokhondriĭ.