[The dose-dependent cytogenetic and growth-inhibiting effects of a new antitumor preparation from the nitrosourea group].
Kinetics of growth-inhibiting and cytogenetic effect of a new carbon-substituted nitrosourea derivative (ADEKO) has been studied in a wide dose range. A linear dose-effect dependence was observed. The level of damaged cells in a population is connected with a number of chromosomal aberrations per cells with a semilogarithmic dependence. The drug has a pronounced clastogenic effect that reveals itself in total damaging of chromosomal structure of tumor cells. It also causes cell polyploidization with the increase in does and duration of action. Chromosomal aberrations induced by the drug are observed in the tumor long after the action of the drug and their level correlates positively with antitumor activity of ADEKO. ADEKO damages preferentially tumor cells as compared to bone marrow.
Fomina
M M
MM
Dzhamanbaev
Zh A
ZhA
Ostrovskaia
L A
LA
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001853:Bone Marrow / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008770:Methylnitrosourea / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors
D000970:Antineoplastic Agents; D008770:Methylnitrosourea; C042070:ADEKO
Dozozavisimyĭ tsitogeneticheskiĭ i rostingibiruiushchiĭ éffekt novogo protivoopukholevogo preparata gruppy nitrozomochevin.