title: [Study on targeting drug delivery system--the characteristics of methotrexate microsphere and experimental treatment of hepatic tumor in rats by arterial embolization].
abstract: Preparation of methotrexate microsphere (MTX-ms) by emulsion-freezing technique was introduced and the experimental results proved that MTX entrapped in the microspheres exhibited good stabilities towards temperature, cobalt-60 radiation and light. The dissolution and inflation rate of the microspheres in pH 7.4 buffer solution at different times measured by Coulter counter was presented. Antitumor activity of MTX-ms after hepatic arterial embolization was examined in a model of liver tumor in Wistar rats. The group of rats treated with MTX-ms showed a rather significant reduction in tumor growth and more extended tumor necrosis as compared with the other groups, e.g. normal saline solution, MTX solution, placebo gelatin-ms and the results demonstrate that the effect of arterial chemoembolization used by MTX-ms is superior to that of the groups either using arterial chemotherapy or arterial embolization alone in treating rat liver cancer.
authors.affiliation: Shanghai Institute of Pharmaceutical Industry.
authors.forename: Q H
authors.initials: QH
authors.lastname: Chen
authors.forename: W G
authors.initials: WG
authors.lastname: Lu
authors.forename: Q H
authors.initials: QH
authors.lastname: Ge
authors.forename: Q
authors.initials: Q
authors.lastname: Sheng
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: X H
authors.initials: XH
authors.lastname: Xie
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: M C
authors.initials: MC
authors.lastname: Wu
authors.forename: X H
authors.initials: XH
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D004355:Drug Stability; D004621:Embolization, Therapeutic; D006499:Hepatic Artery; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use; D008863:Microspheres; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003692:Delayed-Action Preparations; D008727:Methotrexate