Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis.
Sodium bicarbonate (BC) and dichloroacetate (DCA) were studied in 7- to 14-day-old (n = 25) anesthetized swine with hypoxic acidosis. BC (base deficit X kg X 0.3, n = 10), DCA (300 mg/kg, n = 7) or saline (n = 8) was infused for 1 h. Blood lactic acid, dP/dtmax, heart rate and cardiac output increased and base excess and total arterial and carotid resistances (R) decreased with acidosis; aortic pressure, renal and mesenteric R did not change. BC induced higher pH, base excess and lactic acid. Heart rate in all and dP/dtmax with BC and DCA were restored; renal and mesenteric R and aortic pressure decreased in all. Cardiovascular responses to DCA and BC did not differ except for renal R.


CONCLUSIONS
BC is a more effective alkalizer than DCA, which induced a greater renal vasodilation; both restored contractility.
Nudel
D B
DB
Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, N.Y.
Peterson
B J
BJ
Buckley
B J
BJ
Kaplan
N A
NA
Weinhaouse
E
E
Gootman
N
N
D000140:Acidosis, Lactic / Q000188:drug therapy*; D000818:Animals; D000831:Animals, Newborn; D001639:Bicarbonates / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003999:Dichloroacetic Acid / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012964:Sodium / Q000627:therapeutic use*; D017693:Sodium Bicarbonate; D013552:Swine
D001639:Bicarbonates; D007773:Lactates; D019344:Lactic Acid; D017693:Sodium Bicarbonate; D003999:Dichloroacetic Acid; D012964:Sodium