title: Polymorphisms in the VK gene patterns of rheumatoid arthritis patients and control individuals.
abstract: Restriction nuclease digests of DNAs from rheumatoid arthritis patients and control persons were studied by blot hybridization using immunoglobulin VK gene probes of subgroups I-III. Two restriction fragment length polymorphisms (RFLP) were detected in Bg1II digests with a VKI gene probe. One of the RFLPs is linked to rheumatoid arthritis with a relative risk of 5 (p less than 0.01). The observation may be of pathogenetic interest.
authors.affiliation: Institut für Physiologische Chemie, Universität München, BRD.
authors.forename: A
authors.initials: A
authors.lastname: Meindl
authors.forename: H
authors.initials: H
authors.lastname: Kellner
authors.forename: M
authors.initials: M
authors.lastname: Schattenkirchner
authors.forename: H G
authors.initials: HG
authors.lastname: Zachau
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D004247:DNA; D015342:DNA Probes; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
chemical_list: D015342:DNA Probes; D007126:Immunoglobulin Allotypes; D007145:Immunoglobulin kappa-Chains; D004247:DNA