title: [Immunotherapy using high concentration purified antigen showed remarkable effect in all cases].
abstract: Hoya (sea-squirt) asthma is a typical type I occupational asthma. A total of 22 females with this disease whose age ranged from 22 to 69 years were treated for two years with high concentration purified sea-squirt antigen named Ei-M having a molecular weight of 22,800. One case who developed ordinary bronchial asthma abandoned the immunotherapy during the early stage of the therapy, but in the remaining 21 cases remarkable effects were rapidly observed from the early stage of treatment. These cases did not develop asthmatic attacks even through they engaged in oyster shucking work and no symptomatic therapy was indicated. Serum anti-Ei-M IgG antibody was significantly elevated after the therapy. None of the treated cases developed any side effects.
authors.affiliation: Department of Internal Medicine, Hiroshima Prefectural Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Jyo
authors.forename: M
authors.initials: M
authors.lastname: Kuwabara
authors.forename: Y
authors.initials: Y
authors.lastname: Kodomari
authors.forename: T
authors.initials: T
authors.lastname: Katsutani
authors.forename: T
authors.initials: T
authors.lastname: Otsuka
authors.forename: S
authors.initials: S
authors.lastname: Tsuboi
authors.forename: S
authors.initials: S
authors.lastname: Oka
authors.forename: K
authors.initials: K
authors.lastname: Ono
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000941:Antigens / Q000276:immunology / Q000627:therapeutic use*; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008875:Middle Aged; D009784:Occupational Diseases / Q000276:immunology / Q000628:therapy*; D014561:Urochordata / Q000276:immunology*
chemical_list: D000941:Antigens; D007074:Immunoglobulin G