title: Conformation and expression of the albumin gene of young and old rats.
abstract: The conformation and expression of the albumin gene in the liver of young (21-) and old (85-week) rats were studied. Digestion of nuclei with MNase shows no differences in the nucleosomal organization in the coding region of the gene in the two ages. The gene has a DNase I hypersensitive site which is distinctly less sensitive in old rats. Its 5'-CCGG-3' sequences are more methylated in the old in which its rate of transcription is also lower.
authors.affiliation: Department of Zoology, Banaras Hindu University, Varanasi, India.
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: M S
authors.initials: MS
authors.lastname: Kanungo
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000418:Albumins / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D015139:Blotting, Southern; D003850:Deoxyribonuclease I; D005786:Gene Expression Regulation / Q000502:physiology*; D005796:Genes / Q000235:genetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D009690:Nucleic Acid Conformation; D009708:Nucleotidases; D051381:Rats; D011919:Rats, Inbred Strains; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D000418:Albumins; D003850:Deoxyribonuclease I; D009708:Nucleotidases