title: [The effect of polyfunctional macroheterocycles on the rhythmic and contractile activity of the myocardium in animals].
abstract: The effect of the polyfunctional macroheterocycles on the rhythmic and contractile activity of the rat myocardium was found to depend on their concentration. A two-phasic effect upon contractility of the papillary muscles was revealed: a short-term (up to 20 sec) positive inotropic effect followed by a stable depression. The most active drug of this class, dicyclohexano-18-crown-6, prevented the positive inotropic action of classic stimulants (catecholamines and strophantin) upon the contractile function of the heart.
authors.forename: V G
authors.initials: VG
authors.lastname: Shevchuk
authors.forename: A I
authors.initials: AI
authors.lastname: Pliska
authors.forename: V A
authors.initials: VA
authors.lastname: Bidzilia
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004988:Ethers, Cyclic / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D051381:Rats
chemical_list: D002317:Cardiovascular Agents; D004988:Ethers, Cyclic; D006571:Heterocyclic Compounds
vernacular_title: Vliianie polifunktsional'nykh makrogeterotsiklov na ritmicheskuiu i sokratitel'nuiu aktivnost' miokarda zhivotnykh.