Anomalous effect of subconjunctival miconazole on Candida albicans keratitis in rabbits.
After intrastromal injection of a standardized inoculum of Candida albicans blastoconidia in Dutch-belted rabbits, the efficacy of subconjunctival therapy with amphotericin B and miconazole was evaluated using a quantitative isolate recovery technique. The subconjunctival injection of miconazole resulted in the recovery of significantly more viable organisms compared to the number recovered in controls (2,000 micrograms daily, P less than .02; 3,000 micrograms daily, P less than .01, respectively). Amphotericin B, in contrast, in dosages of 500 or 1,500 micrograms daily, had a significant therapeutic effect (P less than .03). The anomalous response to subconjunctival therapy with miconazole seen in this model suggests an effect on host defense mechanisms.
O'Day
D M
DM
Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Head
W S
WS
Robinson
R D
RD
Williams
T E
TE
Gedde
S J
SJ
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy*; D003228:Conjunctiva; D004305:Dose-Response Relationship, Drug; D007634:Keratitis / Q000188:drug therapy* / Q000382:microbiology; D008825:Miconazole / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D011817:Rabbits
D008825:Miconazole; D000666:Amphotericin B