title: Dideoxycytidine toxicity on mouse hemopoietic progenitors.
abstract: Several antiviral compounds showed a toxicity or hemopoietic progenitor cells, 2', 3' Dideoxycytidine (ddc) is the most potent drug in vitro against human T cell lymphotropic viruses and is now being tested on patients with AIDS and AIDS-related complex. We studied its toxicity on mouse hemopoietic progenitors. Results reported here show a toxic activity of ddc but further studies are required to ascertain whether this toxicity is of significance during clinical application.
authors.affiliation: Istituto Scientifico di Medicina Interna, Università di Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mencoboni
authors.forename: R
authors.initials: R
authors.lastname: Lerza
authors.forename: G
authors.initials: G
authors.lastname: Bogliolo
authors.forename: G
authors.initials: G
authors.lastname: Flego
authors.forename: L
authors.initials: L
authors.lastname: Gasparini
authors.forename: I
authors.initials: I
authors.lastname: Pannacciulli
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D003114:Colony-Forming Units Assay; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D010198:Pancytopenia / Q000139:chemically induced*; D016047:Zalcitabine / Q000494:pharmacology / Q000633:toxicity*
chemical_list: D016047:Zalcitabine