Endogenous alkaloids in man--synthesis, analytics, in vivo identification, and medicinal importance.
The in vitro and in vivo condensation of endogenous (or administered) reactive amines and carbonyl compounds is reported, leading to alkaloid-type heterocycles. The spectrum of the presented "mammalian alkaloids" ranges from isoquinoline derivatives, via beta-carbolines, through to thiazolidines, arising from vitamin B6, chloral, and glyoxylic acid, respectively. Formation of these compounds may occur accidentally, but might also be induced intentionally, as a therapy for metabolic diseases.
Bringmann
G
G
Institute of Organic Chemistry, University of Würzburg, Federal Republic of Germany.
Feineis
D
D
Friedrich
H
H
Hille
A
A
D000470:Alkaloids / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D002243:Carbolines / Q000378:metabolism; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism; D008659:Metabolic Diseases / Q000188:drug therapy; D015394:Molecular Structure; D011736:Pyridoxine / Q000737:chemistry / Q000378:metabolism
D000470:Alkaloids; D002243:Carbolines; D007546:Isoquinolines; D011736:Pyridoxine