Effect of beta-adrenergic agonists on lipolysis and lipogenesis by porcine adipose tissue in vitro.
The effects of the beta-adrenergic agonists isoproterenol, cimaterol, ractopamine and clenbuterol on lipolysis (release of glycerol and free fatty acids) and lipogenesis (incorporation of 14C into fatty acids from [14C]glucose) was examined in porcine adipose tissue explants in vitro. Lipolysis was stimulated by isoproterenol, cimaterol or ractopamine but not by clenbuterol. Insulin reduced the lipolytic effects of the beta-adrenergic agonists (isoproterenol, cimaterol and ractopamine). Lipogenesis was inhibited by all beta-adrenergic agonists tested (isoproterenol, cimaterol, ractopamine and clenbuterol). The antilipogenic effect of the beta-adrenergic agonists was reduced by the presence of insulin in the incubation. Although effects of the different beta-adrenergic agonists varied, all had some direct effects that could be expected to reduce adipose accretion. Effects of beta-adrenergic agonists in the pig are due in part to direct effects on adipose tissue.
Peterla
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Dept. of Anim. Sci., Rutgers--The State University, New Brunswick, NJ 08903.
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D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D002976:Clenbuterol / Q000494:pharmacology; D046508:Culture Techniques; D004983:Ethanolamines / Q000494:pharmacology; D005227:Fatty Acids / Q000096:biosynthesis*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D010627:Phenethylamines; C060897:ractopamine; D007545:Isoproterenol; D005990:Glycerol; D002976:Clenbuterol; C047411:cimaterol