Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS.
We report a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes who experienced visual and auditory hallucinations. His blood and cerebrospinal fluid lactate levels were remarkably elevated. Sodium dichloroacetate was administered orally at doses of 12.5 to 100 mg/kg/day. On normalization of the lactate levels, the hallucinations disappeared.
Saijo
T
T
Department of Pediatrics, School of Medicine, University of Tokushima, Japan.
Naito
E
E
Ito
M
M
Takeda
E
E
Hashimoto
T
T
Kuroda
Y
Y
D000140:Acidosis, Lactic / Q000188:drug therapy* / Q000378:metabolism; D000284:Administration, Oral; D000328:Adult; D001307:Auditory Perception / Q000187:drug effects*; D003999:Dichloroacetic Acid / Q000627:therapeutic use*; D006212:Hallucinations / Q000188:drug therapy*; D006801:Humans; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000378:metabolism; D019965:Neurocognitive Disorders / Q000188:drug therapy* / Q000378:metabolism; D009468:Neuromuscular Diseases / Q000188:drug therapy* / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D013577:Syndrome; D014796:Visual Perception / Q000187:drug effects*
D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D003999:Dichloroacetic Acid