Varicocele in the rat: a new experimental model. Effect on histology, ultrastructure and temperature of the testis and the epididymis.
With no consistent animal prototype for the study of varicocele, we set out to create a model in the rat by complete ligation of the main branch of left spermatic vein (MBSV) or by partial ligation of the left renal vein. Three months later, the histology, ultrastructure and temperature of the testis and epididymis were studied. Microscopically, spermatogenic arrest was the most frequent anomaly seen. The most frequently noted ultrastructural change of the testis was distension of smooth endoplasmic reticula in Sertoli cells. The microvilli of columnar epithelia in epididymis were sparse and showed local defects. Lesions and increased temperatures in the testis and epididymis induced by the ligation of the left MBSV were similar to those seen in partial ligation of the left renal veins, with no significant differences between left and right. Significant differences were found, however, on comparison with the controls.
Wang
R
R
Department of Urology, Nanjing Railway Medical College, People's Republic of China.
Chang
J S
JS
Zhou
X M
XM
Chen
D Y
DY
D000818:Animals; D001831:Body Temperature; D004822:Epididymis / Q000098:blood supply / Q000648:ultrastructure*; D008026:Ligation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012082:Renal Veins / Q000601:surgery; D013737:Testis / Q000098:blood supply / Q000648:ultrastructure*; D014646:Varicocele / Q000209:etiology / Q000473:pathology*