Effect of time of dosing relative to a meal on the raft formation of an anti-reflux agent.
Gamma scintigraphy was used in twelve healthy volunteers to establish whether the time of dosing of Liquid Gaviscon relative to a meal influenced its therapeutic action. Indium-113m labelled Liquid Gaviscon was administered to fasted subjects, 30 min after a technetium-99m labelled meal or immediately before ingestion of the meal. The time for 50% of the Gaviscon to empty from the stomach was 0.36 +/- 0.13 h, 3.10 +/- 0.31 h and 0.68 +/- 0.04 h (s.e.m.), respectively. The preparation was found to empty rapidly from the fasted stomach and could not be floated on a meal consumed subsequently. For raft formation to occur, Liquid Gaviscon should be taken 30 min after a meal.
Washington
N
N
Department of Physiology and Pharmacology, Queen's Medical Centre, Nottingham, UK.
Greaves
J L
JL
Wilson
C G
CG
D000328:Adult; D000464:Alginates / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000536:Aluminum Hydroxide / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000863:Antacids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001639:Bicarbonates / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004338:Drug Combinations / Q000008:administration & dosage / Q000493:pharmacokinetics; D005215:Fasting; D005260:Female; D005502:Food; D005746:Gastric Emptying; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D012824:Silicic Acid / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012822:Silicon Dioxide / Q000008:administration & dosage*; D017693:Sodium Bicarbonate; D013270:Stomach / Q000000981:diagnostic imaging
D000464:Alginates; D000863:Antacids; D001639:Bicarbonates; D004338:Drug Combinations; D012824:Silicic Acid; D000536:Aluminum Hydroxide; C007829:alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; D012822:Silicon Dioxide; D017693:Sodium Bicarbonate