Preventive effects of a Chinese herb medicine (sho-saiko-to) against lethality after recombinant human tumor necrosis factor administration in mice.
We observed the effects of a chinese herb medicine Sho-saiko-to on the lethal and antitumor activities of recombinant human tumor necrosis factor (rhTNF) administered in mice. Sho-saiko-to was noted to protect the rhTNF-induced lethality in galactosamine-hypersensitized mice, and also Sho-saiko-to pretreated mice was protected against the decrease of rectal temperature after rhTNF administration. On the other hand, there was a remarkable enhancement of antitumor activity of rhTNF by Sho-saiko-to pretreatment. These results suggest that Sho-saiko-to drug may protect mice from severe shock syndrome induced by rhTNF.
Sakaguchi
S
S
First Department of Hygienic Chemistry, Tohoku College of Pharmacy, Miyagi.
Tutumi
E
E
Yokota
K
K
Furusawa
S
S
Sasaki
K
K
Takayanagi
Y
Y
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005688:Galactosamine / Q000009:adverse effects; D006801:Humans; D006967:Hypersensitivity / Q000517:prevention & control; D008297:Male; D051379:Mice; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000628:therapy*; D012772:Shock, Septic / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000009:adverse effects* / Q000627:therapeutic use
D004365:Drugs, Chinese Herbal; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; C018142:saiko-keishi-to; D005688:Galactosamine