Transfer of 137cesium via rat milk: reduction with ammonium ferric hexacyanoferrate.
Dose-dependent transfer of 137cesium (137Cs) into milk and uptake in suckling rats after a three-day nursing period was studied. On lactation day 9, the dams were administered a single oral dose of cesium, labeled with 137cesium chloride, in six doses from 0.4 to 19.7 micrograms Cs/kg. In addition, one group of rats was given ammonium-ferric(III)-hexacyanoferrate(II) (AFCF). There was a linear dose-dependent relationship between Cs levels in plasma and milk, as well as in whole blood and milk. The Cs milk/plasma ratios were 7 at 24 hr and 6 at 72 hr after Cs administration. Cesium concentration in milk was linearly correlated with tissue levels in suckling offspring at 72 hr. Concentration ratios of cesium in tissues between pups and their lactating dams ranged from 0.5 to 1.2. Repeated treatment with AFCF (50 mg) given orally at 24, 30, 48 and 54 hr after a single administration of 137Cs, resulted in significantly decreased Cs levels in dam's kidney, liver, lung, erythrocytes and blood at 72 hr. In addition, Cs level in milk was decreased by 40% in rats treated with AFCF. However, no effects of AFCF on Cs levels in tissues of suckling pups were observed.
Sundberg
J
J
Toxicology Laboratory, National Food Administration, Uppsala, Sweden.
Oskarsson
A
A
D000818:Animals; D000833:Animals, Suckling; D000931:Antidotes / Q000494:pharmacology*; D001826:Body Fluids / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002588:Cesium Radioisotopes / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D005260:Female; D005295:Ferrocyanides / Q000494:pharmacology*; D007774:Lactation; D008892:Milk / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000931:Antidotes; D002588:Cesium Radioisotopes; D005295:Ferrocyanides; C056252:ammonium iron (III) hexacyanoferrate