Anchor sequence-dependent endogenous processing of human immunodeficiency virus 1 envelope glycoprotein gp160 for CD4+ T cell recognition.
Human CD4+ T cell clones and cell lines were shown to lyse recombinant vaccinia virus-infected cells that synthesize the HIV-1 envelope glycoprotein gp160. The processing of endogenously synthesized gp160 for recognition by CD4+ T cells required that the protein, after synthesis on the rough endoplasmic reticulum and during subsequent cellular transport, remain attached to the luminal/extracellular membrane face by a hydrophobic anchor sequence.
Polydefkis
M
M
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Koenig
S
S
Flexner
C
C
Obah
E
E
Gebo
K
K
Chakrabarti
S
S
Earl
P L
PL
Moss
B
B
Siliciano
R F
RF
D000595:Amino Acid Sequence; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015686:Gene Products, env / Q000276:immunology / Q000378:metabolism*; D015752:Genes, env; D006678:HIV / Q000235:genetics / Q000378:metabolism*; D019302:HIV Envelope Protein gp160; D006801:Humans; D011498:Protein Precursors / Q000276:immunology / Q000378:metabolism*; D021382:Protein Sorting Signals / Q000378:metabolism
D015686:Gene Products, env; D019302:HIV Envelope Protein gp160; D011498:Protein Precursors; D021382:Protein Sorting Signals