Prognostic indicators for invasive carcinoma of the vulva.
Three hundred sixty-five patients with invasive squamous cell carcinoma of the vulva have been treated at M.D. Anderson Cancer Center between 1944 and 1990. We undertook a rigorous review of the medical records, and a Cox proportional hazards model was applied to examine predictors of both failure to survive and recurrence. Significant predictors of both failure to survive and recurrence included tumor size, clinical stage, therapy aim, pelvic or inguinal nodal metastases, and positive margins. We then undertook an analysis of Stage I and II lesions treated with a curative aim to see if there was a difference in survival or in disease-free interval between those patients treated with radical vulvectomy and those treated with radical wide local excision. There was no survival advantage from the radical vulvectomy procedure. We conclude that careful selection may allow us to choose some patients for less radical procedures.
Rutledge
F N
FN
Department of Gynecology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Mitchell
M F
MF
Munsell
M F
MF
Atkinson
E N
EN
Bass
S
S
McGuffee
V
V
Silva
E
E
D002277:Carcinoma / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D014846:Vulvar Neoplasms / Q000401:mortality* / Q000473:pathology