title: Amnioinfusion increases amniotic pressure in pregnant sheep but does not alter fetal acid-base status.
abstract: To investigate the recent suggestion that fetal hypoxemia and acidemia in polyhydramnios are secondary to raised amniotic pressure, 5 to 15 L of normal saline solution was infused intraamniotically at 100 ml/min in seven ewes. Amniotic pressure increased linearly by 1.0 +/- 0.013 (mean +/- SEM) mm Hg per liter infused. Infusion of 15 L produced a mean rise in amniotic pressure of 15.2 +/- 1.2 mm Hg (p less than 0.001) but no significant change in fetal pH, PCO2, PO2, fetal heart rate, or mean arterial pressure. A similar rise in amniotic pressure and lack of change in blood gas values occurred in two control ewes infused intraperitoneally. Rupture of the membranes occurred in two of three amnioinfusions of 15 L. We conclude that acute amnioinfusion raises amniotic pressure in sheep but does not alter fetal blood gas status.
authors.affiliation: Department of Physiology and Biochemistry, University of Reading, Berkshire, United Kingdom.
authors.forename: N M
authors.initials: NM
authors.lastname: Fisk
authors.forename: D A
authors.initials: DA
authors.lastname: Giussani
authors.forename: M J
authors.initials: MJ
authors.lastname: Parkes
authors.forename: P J
authors.initials: PJ
authors.lastname: Moore
authors.forename: M A
authors.initials: MA
authors.lastname: Hanson
mesh_terms: D000650:Amnion; D000818:Animals; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006340:Heart Rate, Fetal; D006863:Hydrogen-Ion Concentration; D007267:Injections / Q000009:adverse effects*; D010100:Oxygen / Q000097:blood; D006831:Polyhydramnios / Q000097:blood*; D011247:Pregnancy; D012756:Sheep
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen