title: [Thrombocyte aggregation in the cat].
abstract: Platelet aggregation in healthy and sick cats after adding various aggregating agents is described. Feline platelets aggregate irreversibly in response to 0.15-1.0 micrograms/ml collagen, 1 microM ADP, 0.3 IU/ml test-thrombin and 0.71 NIH/ml Topostasin. Epinephrine, ristocetin and kaolin failed to cause aggregation. The aggregation function was decreased in a cat with liver damage and icterus; in 2 cats with uremia platelet aggregation was normal. Acetylsalicylic acid (ASA) (10 mg/kg iv) inhibits platelet aggregation in the presence of collagen in low concentrations; high concentrations of collagen succeeded in inducing platelet aggregation.
authors.affiliation: Klinik für kleine Haustiere der Tierärztlichen Hochschule Hannover.
authors.forename: S
authors.initials: S
authors.lastname: Hart
authors.forename: I
authors.initials: I
authors.lastname: Nolte
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D002371:Cat Diseases / Q000097:blood*; D002415:Cats / Q000097:blood*; D003094:Collagen / Q000494:pharmacology*; D004338:Drug Combinations; D006493:Heparin / Q000494:pharmacology; D008107:Liver Diseases / Q000097:blood / Q000662:veterinary; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology; D014511:Uremia / Q000097:blood / Q000662:veterinary
chemical_list: D004338:Drug Combinations; D010975:Platelet Aggregation Inhibitors; C039791:topostasin; D000244:Adenosine Diphosphate; D006493:Heparin; D003094:Collagen; D013917:Thrombin
vernacular_title: Zur Thrombozytenaggregation bei der Katze.