The effect of lidocaine on myocardial ischemia with asanguinous reperfusion. An in vitro study.
The effect of lidocaine on the ischemic nor-mothermic rat heart was studied in a Langendorff preparation. Ventricular fibrillation, total retrograde coronary flow and effluent lactate concentration were monitored in preischemia (control), ischemia (20 min) and reperfusion (20 min). Myocardial metabolites were determined in specimens excised at termination of reperfusion. Six hearts were infused with lidocaine in Ringer solution at onset of ischemia (group A) and six with only Ringer solution (group B). Sinus rhythm proceeded directly to diastolic arrest after 17 sec in group A, while all group B hearts showed ventricular fibrillation before arrest at 174 sec. Effluent lactate concentration was reduced in group A during the first 10 min of ischemia, but not subsequently. After 10 min of reperfusion, coronary flow was reduced by 12% in group A and 20% in group B. ATP was higher and ADP, AMP and IMP were lower in group A than in group B after 20 min of reperfusion. Creatine phosphate showed no intergroup difference, but creatine was higher in group B. Cardiac arrest with lidocaine thus reduced lactate formation during ischemia and lessened high-energy phosphate depletion after reperfusion.
Bengtsson
L
L
Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden.
Gunnes
S
S
Norman
B
B
Karlsson
J
J
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D006324:Heart Arrest, Induced / Q000379:methods*; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D015425:Myocardial Reperfusion / Q000379:methods*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014693:Ventricular Fibrillation / Q000517:prevention & control*
D000227:Adenine Nucleotides; D007773:Lactates; D019344:Lactic Acid; D008012:Lidocaine