title: Progestin and antiprogestin interactions with progesterone receptors in human myomas.
abstract: Progesterone receptors (PRs) in human fibromyomata (myomas) and normal myometrium were characterized by gel filtration, sucrose gradient sedimentation analysis, isoelectrofocusing and ligand specificity. The PR population in myoma tissues, 1242 +/- 505 fmol/mg protein, was 3-fold higher than normal myometrial tissues under similar hormonal milieu. The increased PR concentration in myomas appears to be of potential importance in physiopathology of fibromyoma.
authors.affiliation: Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi.
authors.forename: U
authors.initials: U
authors.lastname: Vij
authors.forename: K
authors.initials: K
authors.lastname: Murugesan
authors.forename: K R
authors.initials: KR
authors.lastname: Laumas
authors.forename: A
authors.initials: A
authors.lastname: Farooq
mesh_terms: D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D007525:Isoelectric Focusing; D007889:Leiomyoma / Q000378:metabolism*; D008024:Ligands; D009640:Norethindrone / Q000378:metabolism*; D011372:Progestins / Q000378:metabolism*; D011485:Protein Binding; D011980:Receptors, Progesterone / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism*
chemical_list: D008024:Ligands; D011372:Progestins; D011980:Receptors, Progesterone; D009640:Norethindrone