Possible role for a plasma factor in the induction and/or maintenance of the state of leukocyte adhesiveness/aggregation in the peripheral blood. A study of mothers and their newborns.
The adhesive property of white blood cells is essential for a normal immune response. We examined the state of leukocyte adhesiveness/aggregation (LAA) in the peripheral blood of 31 mothers and their newborns by means of a direct slide test and found it to differ significantly, the respective per cents of aggregated leukocytes found in the peripheral blood being 15 +/- 6.4 and 5 +/- 3.3 (mean +/- SD). However, the particle concentration of white blood cells in the peripheral blood did not differ significantly (14.2 +/- 4.4 and 13.6 +/- x 10(9) l-1). By incubating a mother's plasma with her newborn's whole blood we could induce a significant (p less than 0.0001) increment in the state of LAA. We conclude that deficiency of a plasma factor that does not cross the placenta is responsible for the low LAA in the newborn's peripheral blood.
Lidor
A
A
Department of Obstetrics and Gynecology B, Serlin Maternity Hospital, Tel Aviv, Israel.
Arber
N
N
Berliner
S
S
Lifshitz
A
A
Segal
G
G
Aronson
M
M
Neri
A
A
Pinkhas
J
J
David
M P
MP
D002448:Cell Adhesion; D002449:Cell Aggregation; D005260:Female; D005312:Fetal Blood / Q000502:physiology*; D005340:Fibrinogen / Q000502:physiology; D005434:Flow Cytometry; D006801:Humans; D007231:Infant, Newborn; D007962:Leukocytes / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology; D010949:Plasma / Q000502:physiology*; D011247:Pregnancy
D005340:Fibrinogen