title: Bone-marrow transplant from father to son and subsequent graft from son to father.
abstract: An 11-year-old boy with acute myeloblastic leukaemia in first remission received an allogeneic mismatched bone-marrow transplant (BMT) from his father in 1979; subsequent HLA typing showed that his haemopoietic system had been repopulated by the donor cells. In 1986 hypereosinophilic syndrome, secondary to a T-cell lymphocytic lymphoma, developed in the father, then aged 45 years. A full haematological remission was obtained by means of standard acute lymphoblastic leukaemia treatment. He then received melphalan, total body irradiation, and a BMT from his son. Graft-versus-host disease was transient in both patients, and father and son remain well and disease-free 20 months and 10 years, respectively, after BMT.
authors.affiliation: Leukaemia Unit, Royal Marsden Hospital, Sutton, Surrey, UK.
authors.forename: R L
authors.initials: RL
authors.lastname: Powles
authors.forename: P M
authors.initials: PM
authors.lastname: Parikh
authors.forename: G
authors.initials: G
authors.lastname: Helenglass
authors.forename: H H
authors.initials: HH
authors.lastname: Aboud
authors.forename: C L
authors.initials: CL
authors.lastname: Smith
authors.forename: I A
authors.initials: IA
authors.lastname: Mrazek
authors.forename: V
authors.initials: V
authors.lastname: Shepherd
authors.forename: S T
authors.initials: ST
authors.lastname: Milliken
authors.forename: J
authors.initials: J
authors.lastname: Treleaven
authors.forename: C
authors.initials: C
authors.lastname: Sharrock
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002648:Child; D003131:Combined Modality Therapy; D004802:Eosinophilia / Q000209:etiology / Q000601:surgery; D005069:Evaluation Studies as Topic; D005190:Family; D005192:Family Health; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology; D006650:Histocompatibility Testing; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D008223:Lymphoma / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012074:Remission Induction / Q000379:methods; D012086:Reoperation; D013601:T-Lymphocytes; D013997:Time Factors