Neuropsychological assessment in multiple sclerosis: a follow-up study with magnetic resonance imaging.
Nineteen moderately impaired patients with clinically definite multiple sclerosis and an initially relapsing-remitting course were included in a neuropsychological and magnetic resonance imaging (MRI) follow-up study. The average test/re-test interval was about 2 years. The neuropsychological findings were indicative of a very mild overall impairment; the patients, as a group, showed no evidence of cognitive deterioration in the follow-up period. A numerical estimation of the severity of cerebral demyelination shown by MRI did not indicate a significant change. No correlation between cognitive performance variations and MRI changes was found.
Mariani
C
C
Istituto di Clinica Neurologica, University of Milan, Italy.
Farina
E
E
Cappa
S F
SF
Anzola
G P
GP
Faglia
L
L
Bevilacqua
L
L
Capra
R
R
Mattioli
F
F
Vignolo
L A
LA
D000328:Adult; D001921:Brain / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000473:pathology / Q000523:psychology*; D009483:Neuropsychological Tests